FN Thomson Reuters Web of Science™ VR 1.0 PT J AU SIMEONSSON, JB LEMIRE, GW SAUSA, RC AF SIMEONSSON, JB LEMIRE, GW SAUSA, RC TI LASER-INDUCED PHOTOFRAGMENTATION PHOTOIONIZATION SPECTROMETRY - A METHOD FOR DETECTING AMBIENT OXIDES OF NITROGEN SO ANALYTICAL CHEMISTRY LA English DT Article ID NITRIC-ACID VAPOR; CHLORINATED HYDROCARBONS; ULTRASENSITIVE DETECTION; MULTIPHOTON IONIZATION; INDUCED FLUORESCENCE; REACTIVE NITROGEN; TRACE GASES; PHOTOLYSIS; FRAGMENTATION; SPECTROSCOPY AB Laser-induced photofragmentation/photoionization (PF/PI) spectrometry has been used to detect trace ambient concentrations of NO, NO2, HNO3 and CH3NO2. The method uses a single laser operating near 226 nm to both fragment the parent molecule and photoionize the resultant NO fragment by a (1 + 1) resonance-enhanced multiphoton ionization (REMPI) process via its A(2) Sigma(+) <-- X(2)II (0,0) band. Ion detection is accomplished by using a pair of miniature electrodes. Use of a single laser and optogalvanic ion detection greatly simplifies the instrumental requirements of the method and allows for real time, in situ monitoring of the above-mentioned compound under ambient conditions. Analytical merits of the technique have been evaluated as a function of the sampling pressure and detection electrode voltage. Limits of detection (LODs) determined for NO, NO2, HNO3 and CH3NO2 are 1, 22, 5, and 220 ppbv, respectively, using 10 mu J of pulse energy and an integration time of 10 s. Results of the study indicate that PF/PI spectrometry enables a simple instrument design to be used for sensitive measurements of these compounds. The high sensitivity is a reflection of the high efficiency of each of the photofragmentation and photoionization processes employed. The ability to use low fluences has the added benefit of suppressing nonresonant multiphoton ionization background signals. Sensitivities demonstrated for species in this study suggest that the technique has excellent potential for measurements of NOx (NO + NO2) and NOy, the concentration of total reactive odd nitrogen compounds. C1 USA,RES LAB,AMSRL WT PC,ABERDEEN PROVING GROUND,MD 21005. NR 39 TC 21 Z9 21 U1 1 U2 7 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0003-2700 J9 ANAL CHEM JI Anal. Chem. PD JUL 15 PY 1994 VL 66 IS 14 BP 2272 EP 2278 DI 10.1021/ac00086a012 PG 7 WC Chemistry, Analytical SC Chemistry GA NX055 UT WOS:A1994NX05500015 ER PT J AU HARTMAN, KR LARUSSA, VF ROTHWELL, SW ATOLAGBE, TO WARD, FT KLIPPLE, G AF HARTMAN, KR LARUSSA, VF ROTHWELL, SW ATOLAGBE, TO WARD, FT KLIPPLE, G TI ANTIBODIES TO MYELOID PRECURSOR CELLS IN AUTOIMMUNE NEUTROPENIA SO BLOOD LA English DT Article ID ACUTE MYELOGENOUS LEUKEMIA; FC RECEPTOR-III; BONE-MARROW; ANTINEUTROPHIL AUTOANTIBODIES; ANTIGENIC TARGETS; HUMAN-NEUTROPHILS; PROGENITOR CELLS; HEMATOPOIESIS; GRANULOPOIESIS; CULTURES C1 WALTER REED ARMY MED CTR,DEPT RHEUMATOL,WASHINGTON,DC 20307. RP HARTMAN, KR (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT HEMATOL,DIV MED,BLDG 40,ROOM 1073,WASHINGTON,DC 20307, USA. NR 44 TC 47 Z9 50 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0006-4971 J9 BLOOD JI Blood PD JUL 15 PY 1994 VL 84 IS 2 BP 625 EP 631 PG 7 WC Hematology SC Hematology GA NX154 UT WOS:A1994NX15400036 PM 7517722 ER PT J AU TAYAG, TJ BATCHMAN, TE SLUSS, JJ AF TAYAG, TJ BATCHMAN, TE SLUSS, JJ TI ELECTRIC-FIELD DEPENDENCE OF THE PHOTOCARRIER HOPPING MOBILITY IN BISMUTH SILICON-OXIDE SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID AMORPHOUS SOLIDS; BI12SIO20; TRANSPORT; CRYSTALS; DIFFRACTION; BI12GEO20 AB The photocarrier mobility of bismuth silicon oxide was measured through a time-of-flight technique. To determine the photocarrier transit time, a method of data analysis was applied that has been developed for transit time dispersion in amorphous solids. The universality of current shape typical of low-mobility amorphous solids was observed and an electric-field dependence of the photocarrier mobility in bismuth silicon oxide is now reported. In accordance with hopping conduction among localized band-gap sites, the photocarrier mobility in bismuth silicon oxide decreases with increasing electric field. C1 UNIV OKLAHOMA,SCH ELECT ENGN,NORMAN,OK 73019. RP TAYAG, TJ (reprint author), USA,RES LAB,OPT PROC BRANCH,AMSRL-SS-IA,2800 POWDER MILL RD,ADELPHI,MD 20783, USA. NR 21 TC 1 Z9 2 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD JUL 15 PY 1994 VL 76 IS 2 BP 967 EP 973 DI 10.1063/1.358517 PG 7 WC Physics, Applied SC Physics GA NX400 UT WOS:A1994NX40000049 ER PT J AU GASKA, R MICKEVICIUS, R MITIN, V STROSCIO, MA IAFRATE, GJ AF GASKA, R MICKEVICIUS, R MITIN, V STROSCIO, MA IAFRATE, GJ TI HOT-ELECTRON RELAXATION DYNAMICS IN QUANTUM WIRES SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID HIGH-FIELD TRANSPORT; PHONON INTERACTION; CARRIER DYNAMICS; ENERGY-LOSS; SCATTERING; RATES AB Monte Carlo simulations of hot nonequilibrium electron relaxation in rectangular GaAs quantum wires of different cross sections are carried out. The simulations demonstrate that the initial stage of hot-electron cooling dynamics is determined by cascade emission of optical phonons and exhibits strong dependence on the excitation energy. The second (slow) relaxation stage is controlled by strongly inelastic electron interactions with acoustic phonons as well as by nonequilibrium (hot) optical phonons. The relaxation times obtained in our simulations are in good agreement with the results of recent luminescence experiments. At low electron concentrations where hot phonon effects are negligible the cascade emission of optical phonons may lead to the overcooling of the electron system to temperature below the lattice temperature. These electrons then slowly (during tens of picoseconds) relax to equilibrium due to the interaction with acoustic phonons. At certain excitation energies strong intersubband electron scattering by optical phonons leads to electron redistribution among subbands and intersubband population inversions. If the electron concentration exceeds 10(5) cm-1, hot phonon effects come into play. In contrast to bulk materials and quantum wells, hot phonon effects in quantum wires exhibit strong dependence on the initial broadening of the energy distribution of the electrons. The very initial electron gas relaxation stage in quantum wires is faster in the presence of hot phonons, while for t>0.5 ps the hot phonon thermalization time defines the characteristic electron cooling time. C1 USA,RES OFF,RES TRIANGLE PK,NC 27709. SCI RES ASSOCIATES INC,GLASTONBURY,CT 06033. RP GASKA, R (reprint author), WAYNE STATE UNIV,DEPT ELECT & COMP ENGN,DETROIT,MI 48202, USA. NR 33 TC 2 Z9 2 U1 1 U2 2 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD JUL 15 PY 1994 VL 76 IS 2 BP 1021 EP 1028 PG 8 WC Physics, Applied SC Physics GA NX400 UT WOS:A1994NX40000058 ER PT J AU ANDREAS, EL AF ANDREAS, EL TI SEA SPRAY AND THE TURBULENT AIR-SEA HEAT FLUXES - REPLY SO JOURNAL OF GEOPHYSICAL RESEARCH-OCEANS LA English DT Letter ID WATER-VAPOR; AEROSOL; GENERATION; DROPLETS; SURFACE RP ANDREAS, EL (reprint author), USA,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 37 TC 9 Z9 9 U1 0 U2 5 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 SN 0148-0227 J9 J GEOPHYS RES-OCEANS JI J. Geophys. Res.-Oceans PD JUL 15 PY 1994 VL 99 IS C7 BP 14345 EP 14350 DI 10.1029/94JC00477 PG 6 WC Oceanography SC Oceanography GA NY037 UT WOS:A1994NY03700023 ER PT J AU YU, SG KIM, KW STROSCIO, MA IAFRATE, GJ BALLATO, A AF YU, SG KIM, KW STROSCIO, MA IAFRATE, GJ BALLATO, A TI ELECTRON-ACOUSTIC-PHONON SCATTERING RATES IN RECTANGULAR QUANTUM WIRES SO PHYSICAL REVIEW B LA English DT Article ID HETEROSTRUCTURES; MODES; CARRIERS AB Electron-acoustic-phonon scattering in a rectangular quantum wire is studied. The Hamiltonian describing the deformation-potential interaction of confined acoustic phonons with carriers is derived by quantizing the appropriate, experimentally verified approximate compressional acoustic-phonon modes in a free-standing rectangular quantum wire. The scattering rate due to the deformation-potential interaction is obtained for GaAs quantum wires with a range of cross-sectional dimensions. The results demonstrate that a proper treatment of confined acoustic phonons may be essential to correctly model electron scattering rates at low energies in nanoscale structures. C1 USA, RES OFF, RES TRIANGLE PK, NC 27709 USA. USA, RES LAB, ELECTR & POWER SOURCES DIRECTORATE, FT MONMOUTH, NJ 07703 USA. RP YU, SG (reprint author), N CAROLINA STATE UNIV, DEPT ELECT & COMP ENGN, RALEIGH, NC 27695 USA. NR 21 TC 67 Z9 67 U1 0 U2 2 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1098-0121 J9 PHYS REV B JI Phys. Rev. B PD JUL 15 PY 1994 VL 50 IS 3 BP 1733 EP 1738 DI 10.1103/PhysRevB.50.1733 PG 6 WC Physics, Condensed Matter SC Physics GA NZ153 UT WOS:A1994NZ15300046 ER PT J AU ERDOGAN, MU SANKARAN, V KIM, KW STROSCIO, MA IAFRATE, GJ AF ERDOGAN, MU SANKARAN, V KIM, KW STROSCIO, MA IAFRATE, GJ TI PHONON-ASSISTED GAMMA-X TRANSITION RATES IN TYPE-II SUPERLATTICES SO PHYSICAL REVIEW B LA English DT Article ID SHORT-PERIOD SUPERLATTICES; QUANTUM-WELLS; INTERSUBBAND RELAXATION; ELECTRON; HETEROSTRUCTURES AB The GAMMA-X transition rate for electrons in type-II superlattices is calculated for the case of optical-phonon emission. The tight-binding method for electronic band structure and the dielectric continuum model for phonons are used. The relative strength of scattering due to different phonon modes is examined for varying superlattice dimensions. The scattering rate is highest when the energy separation between the GAMMA and X levels is smallest, and decreases quickly as the separation increases. It is found that the strongest scattering rate is due to the emission of AlAs confined modes. Changing of parity with layer thickness and its effect on scattering are discussed. C1 USA,RES OFF,RES TRIANGLE PK,NC 27709. RP ERDOGAN, MU (reprint author), N CAROLINA STATE UNIV,DEPT ELECT & COMP ENGN,RALEIGH,NC 27695, USA. NR 22 TC 1 Z9 1 U1 0 U2 1 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0163-1829 J9 PHYS REV B JI Phys. Rev. B PD JUL 15 PY 1994 VL 50 IS 4 BP 2485 EP 2491 PG 7 WC Physics, Condensed Matter SC Physics GA PA187 UT WOS:A1994PA18700055 ER PT J AU BAHDER, TB TOBER, RL BRUNO, JD AF BAHDER, TB TOBER, RL BRUNO, JD TI TEMPERATURE-DEPENDENT POLARIZATION IN [111] INXGA1-XAS-ALXGA1-XAS QUANTUM-WELLS SO PHYSICAL REVIEW B LA English DT Note ID HYDROSTATIC PRESSURE; PIEZOELECTRICITY; FIELD AB Electroreflectance measurements are made over a temperature range 4 K to 470 K to determine the reverse bias at which zero electric field occurs in a [111] growth-axis InxGa1-xAs-AlxGal-xAs strained-layer quantum well (QW) embedded in the intrinsic region of a p-i-n diode. A depletion model of the diode, with embedded InxGa1-xAs QW, is used to extract the dielectric polarization in the QW layer, at zero electric field in the well. We find that the polarization in the QW layer has a significant temperature dependence. This pyroelectric effect is qualitatively similar for InxGal-xAs wells with x=0.10 and x=0.15, but is more pronounced in the latter case. We also find, over the entire temperature range, that the polarization is smaller than the value predicted at room temperature based on the GaAs-InxGal-xAs lattice constant mismatch and bulk-crystal piezoelectric theory. RP BAHDER, TB (reprint author), USA,RES LAB,2800 POWDER MILL RD,ADELPHI,MD 20783, USA. NR 18 TC 19 Z9 19 U1 0 U2 1 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0163-1829 J9 PHYS REV B JI Phys. Rev. B PD JUL 15 PY 1994 VL 50 IS 4 BP 2731 EP 2734 DI 10.1103/PhysRevB.50.2731 PG 4 WC Physics, Condensed Matter SC Physics GA PA187 UT WOS:A1994PA18700096 ER PT J AU CAHILL, S RINZLER, AG OWENS, FJ BULUSU, S AF CAHILL, S RINZLER, AG OWENS, FJ BULUSU, S TI MOLECULAR-COMPLEXES OF EXPLOSIVES WITH CYCLODEXTRINS .2. PREPARATION AND CHARACTERIZATION OF A SOLID COMPLEX OF BETA-CYCLODEXTRIN WITH THE NITRAMINE 1,3,3-TRINITROAZETIDINE (TNAZ) SO JOURNAL OF PHYSICAL CHEMISTRY LA English DT Article ID CRYSTAL-STRUCTURE AB A solid complex between 1,3,3-trinitroazetidine (TNAZ) and beta-cyclodextrin has been isolated for the first time and characterized by the application of solution and solid-state NMR techniques, Raman spectroscopy, and differential scanning calorimetry experiments. All the techniques show clear differences in properties of the solid product from those of a simple physical mixture of the components, and when taken together, they provide convincing evidence for the complex formation. C1 USA,ARMAMENTS RES,CTR DEV & ENGN,DIV ENERGET MAT,PICATINNY ARSENAL,NJ 07806. NR 11 TC 8 Z9 8 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0022-3654 J9 J PHYS CHEM-US JI J. Phys. Chem. PD JUL 14 PY 1994 VL 98 IS 28 BP 7095 EP 7100 DI 10.1021/j100079a033 PG 6 WC Chemistry, Physical SC Chemistry GA NX173 UT WOS:A1994NX17300033 ER PT J AU LAURENCE, WR AF LAURENCE, WR TI RESISTANCE TO ACTIVATED PROTEIN-C SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Letter ID RISK RP LAURENCE, WR (reprint author), WOMACK ARMY MED CTR,FT BRAGG,NC 28307, USA. NR 4 TC 0 Z9 0 U1 0 U2 0 PU MASS MEDICAL SOC PI BOSTON PA 10 SHATTUCK, BOSTON, MA 02115 SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD JUL 14 PY 1994 VL 331 IS 2 BP 129 EP 129 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA NW712 UT WOS:A1994NW71200021 PM 8208260 ER PT J AU VEZZOLI, GC AF VEZZOLI, GC TI CONSIDERATION OF EXCITON MODELS TO EXPLAIN SUPERCONDUCTIVITY TRANSITION ABOVE 150-K IN HGBA2CA2CU3O8+DELTA AT ULTRA-HIGH PRESSURE SO PROCEEDINGS OF THE ROYAL SOCIETY OF LONDON SERIES A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES LA English DT Article ID TC Y1BA2CU3O7-DELTA SUPERCONDUCTOR; MECHANISM AB It has been recently reported that the shoulder of the superconducting transition in HgBa2Ca2Cu3O8+delta can be elevated from ca. 133 K to ca. 153 K as pressure (P) is raised from 1 atm (ca. 10(5) Pa) to 150 kbar (1.5 x 10(10) Pa). The data show an approximately linear T(c) against P up to ca. 17 kbar (1.7 x 10(9) Pa) (hydrostatic), and thereafter (non-hydrostatic) indication of saturation or slope change. It is the purpose of this paper to discuss this pressure enhancement in terms of two general theories of exciton-induced high-T(c) superconductivity, namely the viewpoint of the virtual exciton and that of the condensation of excitons. RP VEZZOLI, GC (reprint author), USA,RES LAB,MAT DIRECTORATE,CERAM RES BRANCH,WATERTOWN,MA 02172, USA. NR 16 TC 0 Z9 0 U1 0 U2 1 PU ROYAL SOC LONDON PI LONDON PA 6 CARLTON HOUSE TERRACE, LONDON, ENGLAND SW1Y 5AG SN 1364-5021 J9 P ROY SOC LOND A MAT JI Proc. R. Soc. London Ser. A-Math. Phys. Eng. Sci. PD JUL 8 PY 1994 VL 446 IS 1926 BP 213 EP 216 DI 10.1098/rspa.1994.0100 PG 4 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA NX304 UT WOS:A1994NX30400013 ER PT J AU STANLEY, DJ WARNE, AG AF STANLEY, DJ WARNE, AG TI WORLDWIDE INITIATION OF HOLOCENE MARINE DELTAS BY DECELERATION OF SEA-LEVEL RISE SO SCIENCE LA English DT Article ID NILE-DELTA; RIVER DELTA; NORTHERN AUSTRALIA; SUBSIDENCE; MARGIN; SHELF; EGYPT; CHINA; RATES AB Radiocarbon-dated deltaic sequences of Holocene age from different parts of the world began to accumulate within a restricted time range, from about 8500 to 6500 years ago. Evaluation of major delta processes indicates that deceleration in sea-level rise was the key factor in Holocene delta formation. Within many deltas, there is as much as a 2000-year age range between basal deposits in seaward and landward cores. This age difference records the progressive landward migration of near mean sea-level depositional environments during the lower to mid-Holocene. Establishment of a chronostratigraphic framework for Holocene delta development provides a fundamental global baseline for distinguishing sea-level change from vertical land motion by tectonism and isostasy, and for evaluating rates of future marine incursion into low-lying deltas. C1 USA,CORPS ENGINEERS,WATERWAYS EXPT STN,VICKSBURG,MS 39180. RP STANLEY, DJ (reprint author), SMITHSONIAN INST,NATL MUSEUM AMER HIST,DELTAS GLOBAL CHANGE PROGRAM,WASHINGTON,DC 20560, USA. NR 69 TC 288 Z9 307 U1 3 U2 28 PU AMER ASSOC ADVANCEMENT SCIENCE PI WASHINGTON PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 SN 0036-8075 J9 SCIENCE JI Science PD JUL 8 PY 1994 VL 265 IS 5169 BP 228 EP 231 DI 10.1126/science.265.5169.228 PG 4 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA NV957 UT WOS:A1994NV95700035 PM 17750665 ER PT J AU BAIRD, D RADVANY, MG SHANLEY, DJ FITZHARRIS, GA AF BAIRD, D RADVANY, MG SHANLEY, DJ FITZHARRIS, GA TI MESENTERIC CYST WITH MILK OF CALCIUM SO ABDOMINAL IMAGING LA English DT Article DE MESENTERIC CYST, MILK OF CALCIUM; ULTRASOUND; COMPUTED TOMOGRAPHY; MAGNETIC RESONANCE IMAGING AB A mesenteric cyst with milk of calcium in an adult patient is presented. Preoperative evaluation included plain film, ultrasound, computed tomography (CT), and magnetic resonance imaging (MRI). To our knowledge, the presence of milk of calcium in a mesenteric cyst has not been previously described. RP BAIRD, D (reprint author), TRIPLER ARMY MED CTR,DEPT RADIOL,HONOLULU,HI 96859, USA. NR 5 TC 4 Z9 4 U1 0 U2 0 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0942-8925 J9 ABDOM IMAGING JI Abdom. Imaging PD JUL-AUG PY 1994 VL 19 IS 4 BP 347 EP 348 PG 2 WC Gastroenterology & Hepatology; Radiology, Nuclear Medicine & Medical Imaging SC Gastroenterology & Hepatology; Radiology, Nuclear Medicine & Medical Imaging GA NR442 UT WOS:A1994NR44200018 PM 8075562 ER PT J AU SAHU, J AF SAHU, J TI NUMERICAL COMPUTATIONS OF SUPERSONIC BASE-FLOW WITH SPECIAL EMPHASIS ON TURBULENCE MODELING SO AIAA JOURNAL LA English DT Note RP SAHU, J (reprint author), USA,RES LAB,ABERDEEN PROVING GROUND,MD 21010, USA. NR 5 TC 31 Z9 31 U1 0 U2 0 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091 SN 0001-1452 J9 AIAA J JI AIAA J. PD JUL PY 1994 VL 32 IS 7 BP 1547 EP 1549 DI 10.2514/3.48296 PG 3 WC Engineering, Aerospace SC Engineering GA NW275 UT WOS:A1994NW27500033 ER PT J AU SHAY, SS JOHNSON, LF AF SHAY, SS JOHNSON, LF TI UPRIGHT REFLUXERS WITHOUT ESOPHAGITIS DIFFERENTIATED FROM BIPOSITIONAL REFLUXERS WITH ESOPHAGITIS BY SIMULTANEOUS MANOMETRY AND PH MONITORING CONDUCTED IN 2 POSTURES BEFORE AND AFTER A MEAL SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Article ID GASTROESOPHAGEAL REFLUX; SPHINCTER; MECHANISMS; RUMINATION AB Objective: To determine whether two dissimilar groups characterized by 24-h esophageal pH monitoring would have individual reflux events that occur under the same or different circumstances when challenged by a meal and monitored in different postures. These groups consisted of upright refluxers without esophagitis (n = 10) versus bipositional refluxers with esophagitis (n = 8). Methods: Our evaluation consisted of a questionnaire completed prior to simultaneous manometry and pH monitoring. This monitoring was conducted over a 120-min period that incorporated the upright and recumbent postures both before and after a meal. Three of our four criteria for reflux were independent of a classic pH event. Results: From the questionnaire, it was apparent that dyspeptic symptoms almost always occurred in the upright refluxers. In addition, provocation for their heartburn had atypical characteristics regarding posture, and their degree of regurgitation was intensified by the postprandial state. During dual monitoring, the upright posture and the meal provoked an increase in frequency of reflux in the upright refluxers, as opposed to only recumbency in the bipositional refluxers. Moreover, reflux events in the upright refluxers usually were associated with Valsalva maneuvers and were recognized as symptoms, two features that were less true in the bipositional refluxers. A similar percentage of reflux events occurred over a low basal lower esophageal sphincter pressure and after a lower esophageal sphincter relaxation, in both groups. Conclusion: The two groups manifested distinctively different reflux characteristics, presumably due to dissimilar mechanisms. C1 WALTER REED ARMY MED CTR,DEPT MED,GASTROENTEROL SERV,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,DEPT MED,DIV DIGEST DIS,BETHESDA,MD 20814. NR 19 TC 14 Z9 14 U1 0 U2 1 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD JUL PY 1994 VL 89 IS 7 BP 992 EP 1002 PG 11 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA NV563 UT WOS:A1994NV56300007 PM 8017397 ER PT J AU BATY, DL VOLZ, JE VONFRAUNHOFER, JA AF BATY, DL VOLZ, JE VONFRAUNHOFER, JA TI FORCE DELIVERY PROPERTIES OF COLORED ELASTOMERIC MODULES SO AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS LA English DT Article ID DEGRADATION AB Elastomeric chains have been used by clinicians for some time to accomplish various treatment objectives. Recently, a number of manufacturers have added colored elastomeric chains to their inventories. The present study was designed to investigate the force delivery capabilities and dimensional stability of these new colored chains. Four different colors of short filament configuration produced by three manufacturers were examined. The force delivery capabilities of each chain were tested at 0 hours and, after storage at 37-degrees-C in air, distilled water, and artificial saliva, at 1 hour, 4 hours, 24 hours, 1 week, 2 weeks, and 3 weeks. A universal testing machine was used to determine the amount of distraction necessary to generate 150 and 300 gf. Dimensional measurements were assessed initially and. after exposure to a simulated oral environment, at 1, 2, and 3 weeks. The data from the force delivery portion of the study were analyzed with a 4-factor factorial analysis of variance. The data compiled from the dimensional stability portion were subjected to a 3-factor factorial analysis of variance. Follow-up Bonferroni simultaneous t tests (family-wise a priori alpha p < 0.05) was used to determine statistical significance of the differences among sets of means. All colored elastomeric chains in the study appeared capable of initially generating force levels compatible with tooth movement. After 24 hours of storage in liquid, the amount of distraction needed to produce 150 and 300 gf substantially increased. The amount of increased need varied among manufacturers. All chains showed an increase in dimensional measurements after 1 week, with little change thereafter. C1 USA,ADV EDUC PROGRAM ORTHODONT,FT KNOX,KY 40121. UNIV LOUISVILLE,LOUISVILLE,KY 40292. RP BATY, DL (reprint author), USA,DENTAC,HSBY DE,FT RILEY,KS 66442, USA. NR 15 TC 17 Z9 24 U1 1 U2 1 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0889-5406 J9 AM J ORTHOD DENTOFAC JI Am. J. Orthod. Dentofac. Orthop. PD JUL PY 1994 VL 106 IS 1 BP 40 EP 46 DI 10.1016/S0889-5406(94)70019-2 PG 7 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA NW520 UT WOS:A1994NW52000005 PM 8017348 ER PT J AU MCCARTY, MJ VUKELJA, SJ AF MCCARTY, MJ VUKELJA, SJ TI ATYPICAL MEDULLARY CARCINOMA OF THE BREAST METASTATIC TO THE ORAL CAVITY SO AMERICAN JOURNAL OF OTOLARYNGOLOGY LA English DT Note RP MCCARTY, MJ (reprint author), BROOKE ARMY MED CTR,DEPT MED,HEMATOL ONCOL SERV,FT SAM HOUSTON,TX 78234, USA. NR 0 TC 4 Z9 4 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0196-0709 J9 AM J OTOLARYNG JI Am. J. Otolaryngol. PD JUL-AUG PY 1994 VL 15 IS 4 BP 289 EP 291 DI 10.1016/0196-0709(94)90098-1 PG 3 WC Otorhinolaryngology SC Otorhinolaryngology GA NX813 UT WOS:A1994NX81300010 PM 7978029 ER PT J AU KIANG, JG CARR, FE BURNS, MR MCCLAIN, DE AF KIANG, JG CARR, FE BURNS, MR MCCLAIN, DE TI HSP-72 SYNTHESIS IS PROMOTED BY INCREASE IN [CA2+](I) OR ACTIVATION OF G-PROTEINS BUT NOT PH(I) OR CAMP SO AMERICAN JOURNAL OF PHYSIOLOGY LA English DT Article DE PERTUSSIS TOXIN; CHOLERA TOXIN; 1,2-BIS(2-AMINOPHENOXY)ETHANE-N,N,N',N'-TETRAACETIC ACID ID HEAT-SHOCK PROTEIN; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR; HUMAN EPIDERMOID-A-431 CELLS; CYTOSOLIC FREE CA2+; GENE-EXPRESSION; PITUITARY-CELLS; A-431 CELLS; DNA-BINDING; FACTOR-I; C-FOS AB The family of 70-kDa heat-shock proteins (HSP-70) is evolutionarily highly conserved and has been shown to enhance cell survival from thermal injury. This study characterized HSP-72 induction in human epidermoid A-431 cells exposed to 45 degrees C for 10 min and determined the relationship between HSP-72, intracellular pH (pH(i)), adenosine 3',5'-cyclic monophosphate (cAMP), G proteins, and intracellular cytosolic free Ca2+ concentration ([Ca2+](i)). Heat shock induced HSP-72 production, which was dependent on both temperature and the duration of heating. This HSP-72 induction was confirmed by Western blot analysis. HSP-72 levels in cells that had been heated then returned to 37 degrees C were elevated at 2 h (1.5 +/- 0.1 x control), reached a maximum at 8 h (2.7 +/- 0.1 x control), and remained above baseline for up to 4 days. Levels of HSP-72 mRNA, determined by dot-blot analysis, reached a maximum at 2 h and returned to baseline within 8 h. Both actinomycin D and cycloheximide blocked HSP-72 induction. Because heating causes intracellular acidification and increases in cAMP and [Ca2+](i), we studied the effect of pH(i), cellular cAMP, and [Ca2+](i) on HSP-72 induction. The reduction of pH(i) to 6.9 by acid loading did not affect the basal level of HSP-72 in unheated cells. Treatment with pertussis toxin, cholera toxin, or forskolin, but not 8-bromo-cAMP, 3-isobutyl-1-methylxanthine, or N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide potentiated heat-induced HSP-72 production. Inhibition of the heat-induced increase in [Ca2+](i) attenuated, but failed to completely block, heat-induced HSP-72 production, mRNA synthesis, and the heat-shock transcriptional factor-heat-shock element binding complex formation, which suggests there are Ca2+-dependent and -independent processes involved in HSP-72 synthesis. Our results show that an increase in [Ca2+](i) or activation of G proteins, but not pH(i) and cAMP, enhances HSP-72 induction. C1 WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. ARMED FORCES RADIOBIOL RES INST,DEPT RADIAT BIOCHEM,BETHESDA,MD. RP KIANG, JG (reprint author), WALTER REED ARMY INST RES,DEPT CLIN PHYSIOL,DIV MED,WASHINGTON,DC 20307, USA. NR 58 TC 54 Z9 54 U1 0 U2 0 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0002-9513 J9 AM J PHYSIOL JI Am. J. Physiol. PD JUL PY 1994 VL 267 IS 1 BP C104 EP C114 PN 1 PG 11 WC Physiology SC Physiology GA NY984 UT WOS:A1994NY98400012 PM 8048473 ER PT J AU SWALLOW, CE MCADAMS, HP COLON, E AF SWALLOW, CE MCADAMS, HP COLON, E TI TUBERCULOSIS MANIFESTED BY A LARYNGEAL MASS ON CT SCANS SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Note C1 UNIFORMED SERV UNIV HLTH SCI,DEPT RADIOL,BETHESDA,MD 20814. RP SWALLOW, CE (reprint author), WALTER REED ARMY MED CTR,DEPT RADIOL,6825 16TH ST NW,WASHINGTON,DC 20307, USA. RI McAdams, Holman/N-8218-2015 OI McAdams, Holman/0000-0002-7044-3320 NR 8 TC 7 Z9 7 U1 0 U2 0 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 SN 0361-803X J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD JUL PY 1994 VL 163 IS 1 BP 179 EP 180 PG 2 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA QE286 UT WOS:A1994QE28600037 PM 8010209 ER PT J AU FRANKE, ED LLANOSCUENTAS, A ECHEVARRIA, J CRUZ, ME CAMPOS, P TOVAR, AA LUCAS, CM BERMAN, JD AF FRANKE, ED LLANOSCUENTAS, A ECHEVARRIA, J CRUZ, ME CAMPOS, P TOVAR, AA LUCAS, CM BERMAN, JD TI EFFICACY OF 28-DAY AND 40-DAY REGIMENS OF SODIUM STIBOGLUCONATE (PENTOSTAM) IN THE TREATMENT OF MUCOSAL LEISHMANIASIS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article AB The efficacy and toxicity of two regimens of antimony, 28 and 40 days of 20 mg of antimony/kg/day, were compared in the treatment of culture-positive mucosal leishmaniasis involving more than one anatomic site. Forty consecutive eligible Peruvians with infiltrative or ulcerative mucosal disease of the lips, nose, palate-uvula-pharynx, or larynx-epiglottis were randomized to receive either 28 days (P28) or 40 days (P40) of sodium stibogluconate (Pentostam). Treatment was prematurely terminated due to thrombocytopenia in three patients and two patients did not complete six months of follow-up. At one month post-treatment, 13% (2 of 16) of the P28 patients and 16% (3 of 19) of the P40 patients no longer had infiltrates or ulcers and were initially considered cured. During a further 11 months of follow-up, infiltrated lesions healed in eight more P28 patients and in 10 more P40 patients. The cure rate after 12 months of follow-up was therefore 63% for both groups (10 of 16 in the P28 group and 12 of 19 in the P40 group). The total of 13 patients who had infiltrates or ulcers at the 9-12-month follow-up were considered failures. All seven patients (three in the P28 group and four in the P40 group) whose lesions were culture-positive for Leishmania at some point in the 12 months after treatment, and who were thereby parasitologic failures, were also clinical failures. Since the cure rates did not differ between the two treatment regimens, there is no therapeutic advantage to increasing the length of treatment with Pentostam to 40 days in patients with mucosal leishmaniasis involving more than one anatomic site. C1 USN,MED RES INST DETACHMENT,MED CTR,LIMA,PERU. UNIV PERUANA CAYETANO HEREDIA,INST MED TROP ALEXANDER VON HUMBOLDT,LIMA,PERU. HOSP REG CUSCO,CUZCO,PERU. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,WASHINGTON,DC 20307. RI Villasante, Eileen/G-3602-2011 NR 5 TC 30 Z9 31 U1 0 U2 3 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JUL PY 1994 VL 51 IS 1 BP 77 EP 82 PG 6 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA PD703 UT WOS:A1994PD70300011 PM 8059918 ER PT J AU SAYSON, SC MONGAN, PD AF SAYSON, SC MONGAN, PD TI ONSET OF ACTION OF MIVACURIUM CHLORIDE - A COMPARISON OF NEUROMUSCULAR BLOCKADE MONITORING AT THE ADDUCTOR POLLICIS AND THE ORBICULARIS OCULI SO ANESTHESIOLOGY LA English DT Article DE MONITORING, ELECTROMYOGRAM NEUROMUSCULAR BLOCKADE; NEUROMUSCULAR RELAXANTS, MIVACURIUM; SKELETAL MUSCLE, ADDUCTOR POLLICIS ORBICULARIS OCULI ID NITROUS-OXIDE FENTANYL; TRACHEAL INTUBATION; D-TUBOCURARINE; HUMANS; VECURONIUM; MUSCLES; ATRACURIUM; PANCURONIUM; ANESTHESIA; DIAPHRAGM AB Background: The optimal site for monitoring neuromuscular blockade for intubations facilitated with mivacurium chloride has not been established. The primary purpose of this evaluation was to determine the difference in onset of neuromuscular blockade between the orbicularis oculi and adductor pollicis in patients administered mivacurium chloride. We also evaluated intubating conditions when intubation was timed to maximal neuromuscular blockade at either the orbicularis oculi or the adductor pollicis. The results for patients administered mivacurium chloride were compared with those for a control group administered succinylcholine. Methods: In a double-blind randomized design, the time to loss of the compound muscle action potential at the orbicularis oculi and adductor pollicis was monitored in 20 patients administered mivacurium chloride and ten patients administered succinylcholine. After administration of mivacurium chloride (0.15 mg.kg(-1)), ten patients underwent tracheal intubation at maximal depression of the orbicularis oculi (group 2) and ten patients at maximal depression of the adductor pollicis (group 3). In an additional ten patients the trachea was intubated 60 s after administration of succinylcholine (1 mg.kg(-1)) (group 1, control). Intubation and evaluation of conditions was performed by one investigator blinded to patient treatments. Results: Loss of compound muscle action potential at the orbicularis oculi and adductor pollicis was more rapid in group 1, and intubation was completed at 86 +/- 26 s. In the patients administered mivacurium chloride, the orbicularis oculi compound muscle action potential was lost 3 min earlier than the adductor pollicis compound muscle action potential. Subsequently, intubation was completed at 134 +/- 50 s in the orbicularis oculi group, whereas the time to intubation was 321 +/- 57 s in the adductor pollicis group. There was no significant differences in intubation conditions between the mivacurium chloride groups. Conclusions: When monitoring 95% twitch height depression of the orbicularis oculi muscle, intubation can be accomplished in approximately 2 min after administration of mivacurium chloride (0.15 mg.kg(-1)). Because intubating conditions were comparable to the patients administered succinylcholine or intubated during monitoring of the twitch height depression of the adductor pollicis, we believe that optimal site for monitoring during intubation using mivacurium chloride is the orbicularis oculi muscle. RP SAYSON, SC (reprint author), BROOKE ARMY MED CTR,DEPT SURG,ANESTHESIOL & OPERAT SERV,FT SAM HOUSTON,TX 78234, USA. NR 21 TC 20 Z9 20 U1 0 U2 2 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0003-3022 J9 ANESTHESIOLOGY JI Anesthesiology PD JUL PY 1994 VL 81 IS 1 BP 35 EP 42 DI 10.1097/00000542-199407000-00007 PG 8 WC Anesthesiology SC Anesthesiology GA NW235 UT WOS:A1994NW23500007 PM 8042808 ER PT J AU SMITH, L AF SMITH, L TI DOES REFINING THE HISTAMINE BRONCHOPROVOCATION TEST IMPROVE OUR ABILITY TO DIAGNOSE ASTHMA SO ANNALS OF ALLERGY LA English DT Editorial Material ID BRONCHIAL HYPERRESPONSIVENESS; RESPIRATORY SYMPTOMS; INHALED HISTAMINE; CHALLENGE TEST; REACTIVITY; METHACHOLINE; CHILDREN; HYPERREACTIVITY; RESPONSIVENESS; SPECIFICITY C1 UNIFORMED SERV UNIV HLTH SCI,DEPT MED,BETHESDA,MD 20814. UNIFORMED SERV UNIV HLTH SCI,DEPT PEDIAT,BETHESDA,MD 20814. RP SMITH, L (reprint author), WALTER REED ARMY MED CTR,ALLERGY CLIN IMMUNOL SERV,WASHINGTON,DC 20307, USA. NR 35 TC 3 Z9 3 U1 0 U2 0 PU AMER COLL ALLERGY ASTHMA IMMUNOLOGY PI ARLINGTON HTS PA 85 WEST ALGONQUIN RD SUITE 550, ARLINGTON HTS, IL 60005 SN 0003-4738 J9 ANN ALLERGY JI Ann. Allergy PD JUL PY 1994 VL 73 IS 1 BP 1 EP 3 PG 3 WC Allergy SC Allergy GA NX601 UT WOS:A1994NX60100001 PM 8030797 ER PT J AU HAYS, JV GILMAN, JK RUBAL, BJ AF HAYS, JV GILMAN, JK RUBAL, BJ TI EFFECT OF MAGNESIUM-SULFATE ON VENTRICULAR RATE CONTROL IN ATRIAL-FIBRILLATION SO ANNALS OF EMERGENCY MEDICINE LA English DT Article AB Study objectives: The objectives of this study were to assess the efficacy of parenteral magnesium sulfate (MgSO4), digoxin, and combined MgSO4-digoxin therapies in acutely lowering ventricular rates in patients with newly recognized atrial fibrillation. Design: A randomized, double-blinded, placebo-controlled clinical study. Setting: US Army tertiary care facility. Participants: Fifteen adults (mean age, 62 +/- 19 years) presenting with newly recognized atrial fibrillation and rapid ventricular rate (more than 99). Interventions: Patients were given an initial parenteral MgSO4 bolus with continuous infusion or placebo. After 30 minutes, all patients were given 0.5 mg IV digoxin and followed for 3.5 hours. Measurements and main results: Ventricular rates were obtained at baseline, every 5 minutes for the first 30 minutes, and then every 30 minutes for 3.5 hours. At 5 minutes, ventricular rates decreased 16 +/- 7% (P<.02) with MgSO4; this was comparable with rate control with digoxin (18 +/- 9%) at 4 hours. Rate control tended (26 +/- 7%) to improve with combined therapy. Conclusion: Parenteral MgSO4 may be useful in the acute management of rapid ventricular rates in patients with atrial fibrillation. RP HAYS, JV (reprint author), BROOKE ARMY MED CTR,CARDIOL SERV,FT SAM HOUSTON,TX 78234, USA. NR 0 TC 23 Z9 23 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0196-0644 J9 ANN EMERG MED JI Ann. Emerg. Med. PD JUL PY 1994 VL 24 IS 1 BP 61 EP 64 DI 10.1016/S0196-0644(94)70163-6 PG 4 WC Emergency Medicine SC Emergency Medicine GA NV283 UT WOS:A1994NV28300010 PM 8010550 ER PT J AU CROSS, AS AF CROSS, AS TI ANTIENDOTOXIN ANTIBODIES - A DEAD-END SO ANNALS OF INTERNAL MEDICINE LA English DT Editorial Material ID GRAM-NEGATIVE BACTEREMIA; ESCHERICHIA-COLI; IGG ANTIBODY; SALMONELLA-MINNESOTA; SEPTIC SHOCK; DOUBLE-BLIND; IMMUNIZATION; ENDOTOXIN; TRIAL; MUTANTS RP CROSS, AS (reprint author), WALTER REED ARMY INST RES,DEPT BACTERIAL DIS,WASHINGTON,DC 20307, USA. NR 18 TC 37 Z9 38 U1 1 U2 1 PU AMER COLL PHYSICIANS PI PHILADELPHIA PA INDEPENDENCE MALL WEST 6TH AND RACE ST, PHILADELPHIA, PA 19106-1572 SN 0003-4819 J9 ANN INTERN MED JI Ann. Intern. Med. PD JUL 1 PY 1994 VL 121 IS 1 BP 58 EP 60 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA PN271 UT WOS:A1994PN27100011 PM 8198349 ER PT J AU JONAS, WB AF JONAS, WB TI THE EFFECTS OF ASPIRIN ON GASTRIC PROSTAGLANDINS SO ANNALS OF INTERNAL MEDICINE LA English DT Letter ID BLEEDING-TIME; PLATELET RP JONAS, WB (reprint author), WALTER REED ARMY INST RES,WASHINGTON,DC 20307, USA. NR 5 TC 0 Z9 0 U1 0 U2 0 PU AMER COLL PHYSICIANS PI PHILADELPHIA PA INDEPENDENCE MALL WEST 6TH AND RACE ST, PHILADELPHIA, PA 19106-1572 SN 0003-4819 J9 ANN INTERN MED JI Ann. Intern. Med. PD JUL 1 PY 1994 VL 121 IS 1 BP 72 EP 72 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA PN271 UT WOS:A1994PN27100014 PM 8198353 ER PT J AU BERMAN, JD AF BERMAN, JD TI STRUCTURE-FUNCTION ANALYSIS OF ANTIMICROTUBULE DINITROANILINES AGAINST PROMASTIGOTES OF THE PARASITIC PROTOZOAN LEISHMANIA-MEXICANA SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Letter RP BERMAN, JD (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307, USA. NR 2 TC 7 Z9 7 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD JUL PY 1994 VL 38 IS 7 BP 1692 EP 1692 PG 1 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA NU598 UT WOS:A1994NU59800049 PM 7979313 ER PT J AU GABRIELSEN, B KIRSI, JJ KWONG, CD CARTER, DA KRAUTH, CA HANNA, LK HUGGINS, JW MONATH, TP KEFAUVER, DF BLOUGH, HA RANKIN, JT BARTZ, CM HUFFMAN, JH SMEE, DF SIDWELL, RW SHANNON, WM SECRIST, JA AF GABRIELSEN, B KIRSI, JJ KWONG, CD CARTER, DA KRAUTH, CA HANNA, LK HUGGINS, JW MONATH, TP KEFAUVER, DF BLOUGH, HA RANKIN, JT BARTZ, CM HUFFMAN, JH SMEE, DF SIDWELL, RW SHANNON, WM SECRIST, JA TI IN-VITRO AND IN-VIVO ANTIVIRAL (RNA) EVALUATION OF OROTIDINE 5'-MONOPHOSPHATE DECARBOXYLASE INHIBITORS AND ANALOGS INCLUDING 6-AZAURIDINE-5'-(ETHYL METHOXYALANINYL)PHOSPHATE (A 5'-MONOPHOSPHATE PRODRUG) SO ANTIVIRAL CHEMISTRY & CHEMOTHERAPY LA English DT Article ID ANTI-HIV ACTIVITY; PHOSPHORAMIDATE DERIVATIVES; PHOSPHATE DERIVATIVES; BIOLOGICAL-ACTIVITY; DENOVO PYRIMIDINE; AGENTS; PYRAZOFURIN; NUCLEOSIDES; NUCLEOTIDES; RIBAVIRIN AB A series of 29 pyrimidines comprising analogues of 6-azauridine (e.g. 2- and 4-thio-6-azauridine), 6-substituted uridines (including several known inhibitors of orotidine 5'-monophosphate decarboxylase, ODCase, e.g. pyrazofurin), and 6-azauridine-5'-(ethyl methoxyalaninyl) phosphate (a potential prodrug of 6-AU-5'-MP) were synthesized and evaluated in vitro and in vivo against five RNA viruses: Japanese encephalitis (JE), yellow fever (YF), sandfly fever (SF), Punta Toro (PT) and Venezuelan equine encephalomyelitis (VEE) viruses. 2-Thio-6-azauridine demonstrated the best in vitro activity against all five viruses. However, in vivo activity was not observed in JE-, PT- and VEE-infected mice. The phosphate prodrug of 6-azauridine was significantly more effective than the parent compound in the PT virus mouse model. Optimum in vivo dose/route/schedule was determined for pyrazofurin in PT-virus-infected mice. C1 USA, MED RES INST INFECT DIS, FREDERICK, MD 35255 USA. SO RES INST, BIRMINGHAM, AL USA. NATL NAVAL MED CTR, BETHESDA, MD 84322 USA. UTAH STATE UNIV, DEPT ANIM DAIRY & VET SCI, LOGAN, UT USA. NR 49 TC 13 Z9 14 U1 0 U2 6 PU BLACKWELL SCIENCE LTD PI OXFORD PA OSNEY MEAD, OXFORD, OXON, ENGLAND OX2 0EL SN 0956-3202 J9 ANTIVIR CHEM CHEMOTH JI Antivir. Chem. Chemother. PD JUL PY 1994 VL 5 IS 4 BP 209 EP 220 PG 12 WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Virology SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Virology GA NW088 UT WOS:A1994NW08800002 ER PT J AU MESCHUTT, D AF MESCHUTT, D TI NAIVE ART - FOLK-ART COLLECTION SO APOLLO-THE INTERNATIONAL MAGAZINE OF THE ARTS LA English DT Letter RP MESCHUTT, D (reprint author), US MIL ACAD,W POINT MUSEUM,W POINT,NY 10996, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU APOLLO MAGAZINE LTD PI LONDON PA 29 CHESHAM PLACE, LONDON, ENGLAND SW1X 8HB SN 0003-6536 J9 APOLLO JI Apollo-Int. Mag. Arts PD JUL PY 1994 VL 140 IS 389 BP 62 EP 62 PG 1 WC Art SC Art GA NX207 UT WOS:A1994NX20700019 ER PT J AU POWERS, EM HERNANDEZ, C BOUTROS, SN HARPER, BG AF POWERS, EM HERNANDEZ, C BOUTROS, SN HARPER, BG TI BIOCIDAL EFFICACY OF A FLOCCULATING EMERGENCY WATER-PURIFICATION TABLET SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY LA English DT Article ID MURIS CYST INACTIVATION; ANIMAL INFECTIVITY; CHLORINE; EXCYSTATION AB Chlor-Floc (CF) emergency water purification tablets were tested for bactericidal, virucidal,, and cysticidal efficacy in water at temperatures ranging from 5 to 25 degrees C. The minimal required log reduction was achieved for bacteria, Giardia mirus, and rotavirus, but CF did not achieve the required log reduction of poliovirus at any of the temperatures or times investigated. The biocidal properties of the CF tablet were equivalent to if not greater than those of the Globaline iodine tablet, and the CF tablet was a more rapid cysticide under several potential use conditions. Therefore, it is a suitable substitute for iodine tablets for emergency purification of drinking water. Clarification of turbid waters was effective, but filtration through a cloth is necessary to prevent flocculated sediment from entering the canteen. The CF tablets met military requirements for emergency water purification and are safe and acceptable for use by the military. C1 ENVIRONM ASSOCIATES,BRADFORD,PA 16701. USA,MAT TEST DIRECTORATE,DUGWAY PROVING GROUND,UT 84022. RP POWERS, EM (reprint author), USA,NATICK RES DEV & ENGN CTR,NATICK,MA 01760, USA. NR 34 TC 8 Z9 8 U1 0 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0099-2240 J9 APPL ENVIRON MICROB JI Appl. Environ. Microbiol. PD JUL PY 1994 VL 60 IS 7 BP 2316 EP 2323 PG 8 WC Biotechnology & Applied Microbiology; Microbiology SC Biotechnology & Applied Microbiology; Microbiology GA NV572 UT WOS:A1994NV57200016 PM 16349318 ER PT J AU LINDBERG, JD DOUGLASS, RE GARVEY, DM AF LINDBERG, JD DOUGLASS, RE GARVEY, DM TI ABSORPTION-COEFFICIENT-DETERMINATION METHOD FOR PARTICULATE MATERIALS SO APPLIED OPTICS LA English DT Article DE ABSORPTION COEFFICIENT MEASUREMENT; ATMOSPHERIC DUST; KUBELKA-MUNK THEORY; POWDERED MATERIALS ABSORPTION AB A method is presented for determining the optical absorption coefficient, or the imaginary refractive index, of particulate material that has been collected from aerosols or hydrosols by means of filtration. The method, based on the Kubelka-Munk theory of diffuse reflectance, is nondestructive and requires no other knowledge of the sample than the amount present, the specific gravity, and an estimate of the real index of refraction. The theoretical development of the method is discussed along with an analysis of photometric and gravimetric errors. We test the method by comparing results obtained for powdered didymium glass with measurements made before the glass was crushed. An example of the method's application to the determination of the absorption coefficient of atmospheric dust at LTV, visible, and near-IR wavelengths is also presented. C1 USA, RES LAB, WHITE SANDS MISSILE RANGE, NM 88002 USA. RP LINDBERG, JD (reprint author), SCI & TECHNOL CORP, 555 TELSHOR 200, LAS CRUCES, NM 88011 USA. NR 8 TC 10 Z9 10 U1 0 U2 2 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 0003-6935 J9 APPL OPTICS JI Appl. Optics PD JUL 1 PY 1994 VL 33 IS 19 BP 4314 EP 4319 PG 6 WC Optics SC Optics GA NY766 UT WOS:A1994NY76600033 PM 20935789 ER PT J AU SIMEONSSON, JB MIZIOLEK, AW AF SIMEONSSON, JB MIZIOLEK, AW TI SPECTROSCOPIC STUDIES OF LASER-PRODUCED PLASMAS FORMED IN CO AND CO2 USING 193, 266, 355, 532 AND 1064NM LASER-RADIATION SO APPLIED PHYSICS B-LASERS AND OPTICS LA English DT Article ID INDUCED BREAKDOWN; ULTRAVIOLET-LASER; MICROPLASMAS; EMISSION; AIR; SPECTROMETRY; FLUORESCENCE; DETECTOR; GASES; ATOMS AB The wavelength dependence of laser-produced breakdown in air, CO and CO2 has been studied using the four Nd:YAG harmonics (266 nm, 355 nm, 532 nm and 1064 nm) and the ArF-excimer laser (193 nm). Breakdown thresholds at these wavelengths are reported for air, CO and CO2. A significant reduction in the breakdown thresholds for both CO and CO2 is apparent when comparing 193 nm with the four Nd:YAG harmonics. This reduction is attributed to the resonance-enhanced two-photon ionization of metastable carbon atoms generated in the laser focus at the ArF-laser wavelength. In addition to reporting breakdown thresholds, the laser-produced plasmas in CO and CO2 are characterized in terms of plasma temperatures and electron densities which are measured by time-resolved emission spectroscopy. Electron densities range from 9 x 10(17) cm-3 to 1 x 10(17) cm-3. Excitation temperatures range from 22 000 K at 0.2 mus to 11 000 K at 2 mus. Ionization temperatures range from 22 000 K at 0.1 mus to 16 000 K at 2 mus. Evidence is presented to indicate that, like ArF-laser-produced plasmas, Nd:YAG-laser-produced plasmas formed in CO and CO2 are in or near a state of Local Thermodynamic Equilibrium (LTE) soon after their formation. RP SIMEONSSON, JB (reprint author), USA,RES LAB,AMSRL WT PC,ABERDEEN PROVING GROUND,MD 21005, USA. NR 34 TC 39 Z9 39 U1 0 U2 7 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0946-2171 J9 APPL PHYS B-LASERS O JI Appl. Phys. B-Lasers Opt. PD JUL PY 1994 VL 59 IS 1 BP 1 EP 9 DI 10.1007/BF01081722 PG 9 WC Optics; Physics, Applied SC Optics; Physics GA NW245 UT WOS:A1994NW24500001 ER PT J AU DILLON, TM MOORE, DW JARVIS, AS AF DILLON, TM MOORE, DW JARVIS, AS TI THE EFFECTS OF STORAGE-TEMPERATURE AND TIME ON SEDIMENT TOXICITY SO ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY LA English DT Article AB The toxicity of an estuarine sediment stored at differ ent temperatures (- 22 degrees C, 4 degrees C, and 25 degrees C) was monitored over time (at 0, 2, 4, 7, and 20 weeks) by conducting 96 h suspended particulate phase (SPP) tests with 24- to 48-h-old Mysidopsis bahia. Toxicity generally increased with time for sediments stored at 4 degrees C and - 22 degrees C. For both temperature treatments, survival was reduced from 40% at week 0 to < 10% at week 12. Survival at 25 degrees C was much more variable, fluctuating between 10% and 90% during the experiment. Reference toxicant tests with sodium dodecyl sulfate (SDS) were conducted throughout the sediment storage experiment. Relative sensitivity to SDS was similar at all time periods except for week 20 where decreased sensitivity was observed. This decreased sensitivity to the reference toxicant corresponded to a significant and uniform increase in survival to all stored sediment samples. C1 USA,WATERWAYS EXPT STN,ENVIRONM EPED LAB,VICKSBURG,MS 39180. NR 14 TC 14 Z9 14 U1 0 U2 1 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0090-4341 J9 ARCH ENVIRON CON TOX JI Arch. Environ. Contam. Toxicol. PD JUL PY 1994 VL 27 IS 1 BP 51 EP 53 PG 3 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA NK798 UT WOS:A1994NK79800010 ER PT J AU TORTELLA, FC ROBLES, L ROSE, J WARD, SJ AF TORTELLA, FC ROBLES, L ROSE, J WARD, SJ TI EVALUATION OF THE COMPARATIVE EEG SPECTRAL PROFILES OF WIN55212-2, A STRUCTURALLY NOVEL CANNABINOID MIMETIC, AND THE SYNTHETIC CANNABINOID LEVONANTRADOL IN THE RAT SO BRITISH JOURNAL OF PHARMACOLOGY LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. STERLING DRUG INC,RENSSELAER,NY 12144. NR 2 TC 0 Z9 0 U1 0 U2 2 PU STOCKTON PRESS PI BASINGSTOKE PA HOUNDMILLS, BASINGSTOKE, HAMPSHIRE, ENGLAND RG21 6XS SN 0007-1188 J9 BRIT J PHARMACOL JI Br. J. Pharmacol. PD JUL PY 1994 VL 112 SU S BP U96 EP U96 PG 1 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA NV610 UT WOS:A1994NV61000175 ER PT J AU ROBERTS, DE SAWKA, MN YOUNG, AJ FREUND, BJ AF ROBERTS, DE SAWKA, MN YOUNG, AJ FREUND, BJ TI PYRIDOSTIGMINE BROMIDE DOES NOT ALTER THERMOREGULATION DURING EXERCISE IN COLD-AIR SO CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY LA English DT Article DE ANTICHOLINESTERASE; COLD-INDUCED VASOCONSTRICTION; COLD-INDUCED THERMOGENESIS; COLD STRESS; INSULATIVE SHELL; BODY TEMPERATURE REGULATION ID PHYSIOLOGICAL-RESPONSES; HEAT AB This study examined the effects of acute and chronic pyridostigmine bromide (PB) administration on thermoregulatory and metabolic responses to exercise in cold air (5 degrees C). Seven healthy men completed two 7-day trials in a double-blind, crossover experimental design: during one trial they received PB (30 mg three times daily) and during the other trial they received placebo. For each trial, subjects attempted four (3 h) exercise tests: low-intensity exercise (similar to 25% VO(2)max) and moderate-intensity exercise (similar to 50% VO(2)max), on days 2 and 3 and again on days 6 and 7. Metabolic rate, body temperatures, and venous blood samples were obtained before and during exercise. Red blood cell acetylcholinesterase inhibition induced by PB increased (p < 0.05) from 34% on day 1 to 43% on days 3-7. Metabolic rate, body temperatures, and regional heat conductance responses were not different between trials. Plasma glucose, glycerol, free fatty acid, lactate, sodium, and potassium concentrations were not different between trials. In addition, differences were not found between acute and chronic experiments for any thermoregulatory or metabolic responses. These findings demonstrate that the PB dosage used by military personnel, as a pharmacological defense against nerve-agent poisoning, should not cause any adverse thermoregulatory or metabolic effects during moderate activity in cold climates. C1 USA,ENVIRONM MED RES INST,DIV THERMAL PHYSIOL & MED,NATICK,MA 01760. NR 24 TC 3 Z9 3 U1 0 U2 0 PU NATL RESEARCH COUNCIL CANADA PI OTTAWA PA RESEARCH JOURNALS, MONTREAL RD, OTTAWA ON K1A 0R6, CANADA SN 0008-4212 J9 CAN J PHYSIOL PHARM JI Can. J. Physiol. Pharmacol. PD JUL PY 1994 VL 72 IS 7 BP 788 EP 793 PG 6 WC Pharmacology & Pharmacy; Physiology SC Pharmacology & Pharmacy; Physiology GA PF155 UT WOS:A1994PF15500012 PM 7828087 ER PT J AU SRINIVASAN, R HALL, RR WILSON, WD LOEHLE, WD ALLBEE, DC AF SRINIVASAN, R HALL, RR WILSON, WD LOEHLE, WD ALLBEE, DC TI FORMATION OF A POROUS, PATTERNABLE, ELECTRICALLY CONDUCTING CARBON NETWORK BY THE ULTRAVIOLET-LASER IRRADIATION OF THE POLYIMIDE PMDA-ODA (KAPTON) SO CHEMISTRY OF MATERIALS LA English DT Note C1 US MIL ACAD,PHOTON RES CTR,W POINT,NY 10996. US MIL ACAD,DEPT CHEM,W POINT,NY 10996. RP SRINIVASAN, R (reprint author), UVTECH ASSOCIATES,98 CEDAR LANE,OSSINING,NY 10562, USA. NR 8 TC 2 Z9 2 U1 0 U2 8 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0897-4756 J9 CHEM MATER JI Chem. Mat. PD JUL PY 1994 VL 6 IS 7 BP 888 EP 889 DI 10.1021/cm00043a005 PG 2 WC Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA NY893 UT WOS:A1994NY89300005 ER PT J AU WILLIAMS, WJ RADULOVIC, S DASCH, GA LINDSTROM, J KELLY, DJ OSTER, CN WALKER, DH AF WILLIAMS, WJ RADULOVIC, S DASCH, GA LINDSTROM, J KELLY, DJ OSTER, CN WALKER, DH TI IDENTIFICATION OF RICKETTSIA-CONORII INFECTION BY POLYMERASE CHAIN-REACTION IN A SOLDIER RETURNING FROM SOMALIA SO CLINICAL INFECTIOUS DISEASES LA English DT Article ID MEDITERRANEAN SPOTTED-FEVER; TICK-BITE FEVER; IMMUNOFLUORESCENT DEMONSTRATION; MONOCLONAL-ANTIBODIES; LABORATORY DIAGNOSIS; BOUTONNEUSE FEVER; CUTANEOUS LESIONS; CLINICAL-FEATURES; MICROIMMUNOFLUORESCENCE; DISEASES AB A soldier developed characteristic manifestations of boutonneuse fever shortly after leaving Somalia. Rickettsial DNA was detected in a biopsy sample of the tache noire by a polymerase chain reaction (PCR) in which primers derived from the 190-kD antigen gene of Rickettsia rickettsii were used. The source of this DNA was identified as Rickettsia conorii by restriction fragment length polymorphism (RFLP) analysis of the PCR product. R. conorii was also isolated from the skin biopsy specimen. The patient did not develop a significant increase in specific antibodies, as assessed by indirect fluorescent antibody testing, until several weeks after the onset of symptoms. This case demonstrates that the PCR/RFLP technique can be used for the direct identification of rickettsiae from clinical specimens. To our knowledge, this is the first confirmed case of R. conorii infection in Somalia. C1 WALTER REED ARMY MED CTR, INFECT DIS SERV, WASHINGTON, DC 20307 USA. WALTER REED ARMY MED CTR, DERMATOL SERV, WASHINGTON, DC 20307 USA. UNIV TEXAS, MED BRANCH, DEPT PATHOL, GALVESTON, TX 77550 USA. NATL NAVAL MED CTR, VIRAL & RICKETTSIAL DIS PROGRAM, BETHESDA, MD 20814 USA. NR 38 TC 17 Z9 17 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD JUL PY 1994 VL 19 IS 1 BP 93 EP 99 PG 7 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA NX665 UT WOS:A1994NX66500016 PM 7948564 ER PT J AU HAMLIN, LM DELAPLAIN, CB AF HAMLIN, LM DELAPLAIN, CB TI BONE SPECT IN BAASTRUPS-DISEASE SO CLINICAL NUCLEAR MEDICINE LA English DT Note C1 TRIPLER ARMY MED CTR,DEPT RADIOL,NUCL MED SERV,HONOLULU,HI 96859. NR 1 TC 9 Z9 9 U1 1 U2 1 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0363-9762 J9 CLIN NUCL MED JI Clin. Nucl. Med. PD JUL PY 1994 VL 19 IS 7 BP 640 EP 641 DI 10.1097/00003072-199407000-00018 PG 2 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA NW986 UT WOS:A1994NW98600018 PM 7924110 ER PT J AU MAYER, MH AF MAYER, MH TI CLINICAL PERSPECTIVES ON BONE-GRAFTING - AVOIDING THE COMPLICATIONS OF DEVELOPMENTAL MALFORMATIONS SO CLINICS IN PLASTIC SURGERY LA English DT Article RP MAYER, MH (reprint author), WALTER REED ARMY MED CTR,CRANIOFACIAL CLEFT LIP & PALATE CLIN,6900 GEORGIA AVE NW,WASHINGTON,DC 20307, USA. NR 0 TC 6 Z9 6 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0094-1298 J9 CLIN PLAST SURG JI Clin. Plast. Surg. PD JUL PY 1994 VL 21 IS 3 BP 365 EP 376 PG 12 WC Surgery SC Surgery GA NW957 UT WOS:A1994NW95700004 PM 7924134 ER PT J AU ANDERSON, RS MORA, LM THOMSON, SA AF ANDERSON, RS MORA, LM THOMSON, SA TI MODULATION OF OYSTER (CRASSOSTREA-VIRGINICA) HEMOCYTE IMMUNE FUNCTION BY COPPER, AS MEASURED BY LUMINOL-ENHANCED CHEMILUMINESCENCE SO COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY LA English DT Article DE HEMOCYTES; COPPER TOXICITY; LUMINOL-ENHANCED CHEMILUMINESCENCE; OYSTER; CRASSOSTREA VIRGINICA; IMMUNE FUNCTION; HEMOLYMPH; MOLLUSK ID CHEMI-LUMINESCENCE; PHAGOCYTES; DEFENSE; BIVALVES; INVITRO; AGENTS AB The release by oyster (Crassostrea virginica) hemocytes of reactive oxygen intermediates, thought to be involved in host antimicrobial defense mechanisms, is stimulated by phagocytosis. This can be quantified by luminol-augmented chemiluminescence (LCL). Exposure of the hemocytes to sublethal concentrations of copper will produce a dose-dependent suppression of LCL. The results indicate that copper is a potential environmental immunotoxicant for mollusks, impairing the ability of the cells to mount a typical protective response. C1 USA,EDGEWOOD RES DEV & ENGN CTR,SCBRD-RTL,ABERDEEN PROVING GROUND,MD 21010. RP ANDERSON, RS (reprint author), UNIV MARYLAND,CHESAPEAKE BIOL LAB,POB 38,SOLOMONS,MD 20688, USA. NR 26 TC 40 Z9 40 U1 2 U2 3 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0742-8413 J9 COMP BIOCHEM PHYS C JI Comp. Biochem. Physiol. C-Pharmacol. Toxicol. Endocrinol. PD JUL PY 1994 VL 108 IS 2 BP 215 EP 220 DI 10.1016/1367-8280(94)90033-7 PG 6 WC Biochemistry & Molecular Biology; Endocrinology & Metabolism; Toxicology; Zoology SC Biochemistry & Molecular Biology; Endocrinology & Metabolism; Toxicology; Zoology GA PK260 UT WOS:A1994PK26000010 ER PT J AU LEGGETT, DC PARKER, LV AF LEGGETT, DC PARKER, LV TI MODELING THE EQUILIBRIUM PARTITIONING OF ORGANIC CONTAMINANTS BETWEEN PTFE, PVC, AND GROUNDWATER SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID SOLVATION ENERGY RELATIONSHIPS; WELL CONSTRUCTION; PI-STAR; WATER; COEFFICIENTS; EQUATION; SAMPLES; SOLUTES; PREDICTION; SORPTION AB Sorption of contaminants by organic polymers used in well casings and sampling devices has the potential to bias the results of groundwater analysis. Until now, no attempt has been made to explain quantitatively the results of sorption experiments. Here a multiparameter linear solvation energy relationship (LSER) was developed to describe the equilibrium partitioning between water, PVC, and PTFE of a group of organic compounds selected for their interest to environmental agencies as potential groundwater contaminants. Partitioning of these solutes was related to their basicity (beta), acidity, polarity/polarizability, and molecular volume. These models proved more accurate than octanol/water partition coefficients in correlating the experimental partitioning data. This is because specific interactions with the materials and with octanol restrict its usefulness as a surrogate. RP LEGGETT, DC (reprint author), USA,COLD REG RES & ENGN LAB,HANOVER,NH 03755, USA. NR 30 TC 7 Z9 7 U1 1 U2 9 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0013-936X J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD JUL PY 1994 VL 28 IS 7 BP 1229 EP 1233 DI 10.1021/es00056a008 PG 5 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA NU808 UT WOS:A1994NU80800009 PM 22176312 ER PT J AU WIZEL, B ROGERS, WO HOUGHTEN, RA LANAR, DE TINE, JA HOFFMAN, SL AF WIZEL, B ROGERS, WO HOUGHTEN, RA LANAR, DE TINE, JA HOFFMAN, SL TI INDUCTION OF MURINE CYTOTOXIC T-LYMPHOCYTES AGAINST PLASMODIUM-FALCIPARUM SPOROZOITE SURFACE PROTEIN-2 SO EUROPEAN JOURNAL OF IMMUNOLOGY LA English DT Article DE CYTOTOXIC T CELLS; MALARIA; PFSSP2 ID LIPOSOME-MEDIATED DELIVERY; CLASS-I MOLECULES; CIRCUMSPOROZOITE PROTEIN; VACCINIA VIRUS; SELF-PEPTIDES; ANTIGEN-PRESENTATION; PRESENTATION PATHWAY; MALARIA SPOROZOITES; CELLS RECOGNIZE; SOLUBLE-ANTIGEN AB Sporozoite surface protein 2 has been identified as a target of malaria vaccines designed to produce protective CD8(+) cytotoxic T lymphocytes (CTL) because mice immunized with mastocytoma cells expressing a fragment of Plasmodium yoelii sporozoite surface protein 2 (PySSP2) are protected against malaria by an immune response that requires CD8(+) CTL. To define CTL epitopes in the Plasmodium falciparum sporozoite surface protein 2 (PfSSP2), spleen cells (SC) from mice immunized with irradiated sporozoites (irr spz) were stimulated with synthetic peptides, and these effecters were tested for cytolytic activity against peptide-pulsed, major histocompatibility complex (MHC)-matched targets. Two peptides containing CTL epitopes, A6 (Pf SSP2 3D7 214-233) and BH1 (Pf SSP2 3D7 3-11) were identified in bulk cultures of SC from immune C57BL/6 mice, and by production of CTL lines. Immunization with recombinant vaccinia expressing the full length PfSSP2 induced antigen specific, MHC-restricted, CD8(+) T cell-dependent cytolytic activity against these two peptides. Finally CTL were induced by immunization with a bacteria-derived recombinant fragment of PfSSP2 (rPfSSP2) mixed with a liposomal formulation containing a cationic lipid (Lipofectin(R) Reagent, LPF). Induced CTL lysed target cells pulsed with peptide A6 or with LPF/rPfSSP2, but not targets pulsed with only rPfSSP2. These studies demonstrate that CTL specific to PfSSP2 are present in C57BL/6 mice and that immunization with purified rPfSSP2 delivered with LPF induces a cytotoxic T cell response. C1 USN,MED RES INST,MALARIA PROGRAM,BETHESDA,MD. JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,DEPT IMMUNOL & INFECT DIS,BALTIMORE,MD. TORREY PINES INST MOLEC STUDIES,SAN DIEGO,CA. WALTER REED ARMY INST RES,DEPT IMMUNOL,WASHINGTON,DC. VIROGENET CORP,TROY,NY 12180. RI Lanar, David/B-3560-2011 NR 59 TC 24 Z9 24 U1 0 U2 0 PU VCH PUBLISHERS INC PI DEERFIELD BEACH PA 303 NW 12TH AVE, DEERFIELD BEACH, FL 33442-1788 SN 0014-2980 J9 EUR J IMMUNOL JI Eur. J. Immunol. PD JUL PY 1994 VL 24 IS 7 BP 1487 EP 1495 DI 10.1002/eji.1830240705 PG 9 WC Immunology SC Immunology GA NX261 UT WOS:A1994NX26100003 PM 7517870 ER PT J AU PRESTON, KL PELUSO, FE GOLDNER, F AF PRESTON, KL PELUSO, FE GOLDNER, F TI OPTIMAL BOWEL PREPARATION FOR FLEXIBLE SIGMOIDOSCOPY - ARE 2 ENEMAS BETTER THAN ONE SO GASTROINTESTINAL ENDOSCOPY LA English DT Article AB Recommendations regarding optimal bowel preparation for fiberoptic flexible sigmoidoscopy remain anecdotal and inconclusive. We prospectively evaluated three commonly recommended regimens for administering hypertonic phosphate enemas to subjects undergoing 60-cm fiberoptic flexible sigmoidoscopy for routine indications. Patients were randomly assigned to one of three hypertonic phosphate enema regimens. Group A received one enema 1 hour before fiberoptic flexible sigmoidoscopy, group B received two enemas 1 hour before, and group C received one enema 3 hours before and a second enema 1 hour before fiberoptic flexible sigmoidoscopy. Adequacy of bowel preparation was graded as excellent, adequate, or poor. Results revealed no statistically significant difference in the adequacy of bowel preparation between the three regimens, all resulting in adequate or excellent preparation in approximately 80% of patients. We recommend the use of one hypertonic phosphate enema 1 hour before routine fiberoptic flexible sigmoidoscopy. Implementation of this recommendation is efficacious, convenient for patients, and cost-effective. C1 BROOKE ARMY MED CTR,DEPT MED,GASTROENTEROL SERV,FT SAM HOUSTON,TX 78234. RI Preston, Kenzie/J-5830-2013 OI Preston, Kenzie/0000-0003-0603-2479 NR 7 TC 17 Z9 18 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0016-5107 J9 GASTROINTEST ENDOSC JI Gastrointest. Endosc. PD JUL-AUG PY 1994 VL 40 IS 4 BP 474 EP 476 PG 3 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA NY866 UT WOS:A1994NY86600014 PM 7926539 ER PT J AU FRANCIS, JM KADAKIA, SC AF FRANCIS, JM KADAKIA, SC TI ANOMALOUS DOUBLE ORIFICE OF A SINGLE MAJOR PAPILLA OF VATER SO GASTROINTESTINAL ENDOSCOPY LA English DT Letter ID ODDI DYSFUNCTION; CHOLECYSTECTOMY; SPHINCTER RP FRANCIS, JM (reprint author), BROOKE ARMY MED CTR,SAN ANTONIO,TX, USA. NR 9 TC 1 Z9 1 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0016-5107 J9 GASTROINTEST ENDOSC JI Gastrointest. Endosc. PD JUL-AUG PY 1994 VL 40 IS 4 BP 524 EP 525 PG 2 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA NY866 UT WOS:A1994NY86600038 PM 7926559 ER PT J AU SPARLIN, MA LEWIS, RD AF SPARLIN, MA LEWIS, RD TI INTERPRETATION OF THE MAGNETIC ANOMALY OVER THE OMAHA OIL-FIELD, GALLATIN-COUNTY, ILLINOIS SO GEOPHYSICS LA English DT Article ID MADRID SEISMIC ZONE; MISSISSIPPI EMBAYMENT; TECTONIC DEVELOPMENT; RIFT COMPLEX AB A 40 nanoTesla (nT) magnetic anomaly identified in an aeromagnetic survey over southern Illinois contours as a localized magnetic high on the west flank of a regional magnetic low. This magnetic anomaly is generally coincident with the Omaha Oil Field in northwest Gallatin County, Illinois. It was initially assumed that cultural sources of steel associated with this oil field were the primary source of the magnetic feature; however, similar oil fields overflown by the survey do not exhibit magnetic anomalies in the data set. The Luther Rister et ux #1 well, drilled near the apex of the Omaha structural dome, encountered two zones of ultramafic intrusive rock containing 9.0 percent by volume magnetite. These intrusives were identified to be alnoites which are a class of mantle-derived ultramafic rock that can be associated with the incipient stages of crustal rifting. A ground magnetic survey verified the presence of the anomaly, and provided detailed data for 3-D modeling of the source. Petrophysical evaluations, magnetic susceptibility measurements and thin section modal analysis were made on drill cuttings from the ultramafic intrusives encountered in the Luther Rister #1 well. These measurements were made to constrain the 3-D magnetic modeling by the petrophysical characteristics of the source. After removal of the regional magnetic field, the resulting 140 nT residual magnetic anomaly was successfully modeled using two ultramafic sills with an igneous feeder plug. The two igneous sills adequately account for the structural closure exhibited in the Omaha Oil Field and raise the interesting possibility of other hydrocarbon trapping structures generated by intrusives emplaced into the sedimentary section. C1 SCHLUMBERGER TECHNOL CORP,HOUSTON,TX. USA,CORPS ENGINEERS,WATERWAYS EXPT STN,VICKSBURG,MS 39180. NR 31 TC 7 Z9 7 U1 0 U2 1 PU SOC EXPLORATION GEOPHYSICISTS PI TULSA PA 8801 S YALE ST, TULSA, OK 74137 SN 0016-8033 J9 GEOPHYSICS JI Geophysics PD JUL PY 1994 VL 59 IS 7 BP 1092 EP 1099 DI 10.1190/1.1443665 PG 8 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA NV879 UT WOS:A1994NV87900007 ER PT J AU LINDE, K JONAS, WB MELCHART, D WORKU, F WAGNER, H EITEL, F AF LINDE, K JONAS, WB MELCHART, D WORKU, F WAGNER, H EITEL, F TI CRITICAL-REVIEW AND METAANALYSIS OF SERIAL AGITATED DILUTIONS IN EXPERIMENTAL TOXICOLOGY SO HUMAN & EXPERIMENTAL TOXICOLOGY LA English DT Review ID CLINICAL-TRIALS; HORMESIS; STIMULATION; HOMEOPATHT; KINETICS; GROWTH; SILICA; MODEL AB 1 We conducted an overview and quantitative meta-analysis of all experimental literature on the protective effects of serial agitated dilutions (SADs) of toxin preparations. 2 Articles were systematically collected and evaluated for scientific quality using pre-defined methodological criteria and then independently analysed for validity. 3 We found 105 publications exploring the effects of SAD preparations in toxicological systems. 4 The quality of evidence in these studies was low with only 43% achieving one half of the maximum possible quality score and only 31% reported in a fashion that permitted reevaluation of the data. 5 Very few studies were independently replicated using comparable models. 6 Among the high quality studies, positive effects were reported 50% more often than negative effects. 7 Four of 5 outcomes meeting quality and comparability criteria for meta-analysis showed positive effects from SAD preparations. 8 Average percent protection over controls in these preparations was 19.7 (95% CI 6,2-33.2). 9 Further research with special attention to methodological detail and independent replication should be done. C1 WALTER REED ARMY INST RES,DIV MED,WASHINGTON,DC 20307. UNIV MUNICH,PROJEKT MUNCHENER MODELL,W-8000 MUNICH 2,GERMANY. UNIV MUNICH,CHIRURG KLIN & POLIKLIN INNENSTADT,W-8000 MUNICH 2,GERMANY. UNIV MUNICH,INST PHARMAZEUT BIOL,W-8000 MUNICH 2,GERMANY. OI Linde, Klaus/0000-0002-2902-970X NR 140 TC 74 Z9 74 U1 1 U2 4 PU STOCKTON PRESS PI BASINGSTOKE PA HOUNDMILLS, BASINGSTOKE, HAMPSHIRE, ENGLAND RG21 6XS SN 0144-5952 J9 HUM EXP TOXICOL JI Hum. Exp. Toxicol. PD JUL PY 1994 VL 13 IS 7 BP 481 EP 492 PG 12 WC Toxicology SC Toxicology GA NW139 UT WOS:A1994NW13900006 PM 7917505 ER PT J AU ELKINS, KL ENNIST, DL WINEGAR, RK WEIR, JP AF ELKINS, KL ENNIST, DL WINEGAR, RK WEIR, JP TI IN-VIVO DELIVERY OF INTERLEUKIN-4 BY A RECOMBINANT VACCINIA VIRUS PREVENTS TUMOR-DEVELOPMENT IN MICE SO HUMAN GENE THERAPY LA English DT Article ID STIMULATORY FACTOR-I; IMMUNODEFICIENT MICE; NECROSIS-FACTOR; GAMMA-INTERFERON; GENE-THERAPY; CELL-GROWTH; VECTOR; EXPRESSION; INFECTION; INVIVO AB To study the immunotherapeutic potential of interleukin-4 (IL-4) delivered in vivo via a recombinant vaccinia virus, a thymidine kinase-negative (TK-) vaccinia virus that expressed the murine IL-4 gene (VV1/IL-4) was constructed. When mice were inoculated with 10(7) plaque-forming units (pfu) of VV1/IL-4 subcutaneously (s.c.), 10(5) pfu/cm(2) were found in skin, and smaller numbers in liver and kidney between 1 and 7 days after infection; few viral pfu were found in spleen and lung, or in any organ after intravenous infection. This suggested that recombinant vaccinia viruses might be most efficient at delivery of cytokine genes to the skin. Because IL-4 has recently been found to have potent anti-tumor activity, the effect of recombinant virus infection on the development of s.c. tumors was studied. A single s.c. inoculation with VV1/IL-4 delayed the development of NCTC 2472 tumors, but when VV1/IL-4 was inoculated s.c. weekly for 8 weeks, turner development was completely prevented in 93% of mice. Similarly, the development of M-3 melanoma tumors was also prevented by weekly s.c. inoculations of VV1/IL-4. About 40% of mice treated with control VV2/beta gal by the same regimen also failed to develop tumors. Weekly virus treatment did not prevent NCTC 2472 tumor development in athymic nu/nu mice, suggesting that mature T cells are required for expression of VV1/IL-4 induced antitumor activity. Thus, recombinant vaccinia viruses may be especially well suited for convenient therapeutic delivery of immunomodulator genes to skin-related sites. C1 WALTER REED ARMY INST RES,DEPT CELLULAR IMMUNOL,ROCKVILLE,MD 20852. NICHHD,DEV & MOLEC IMMUN LAB,BETHESDA,MD 20892. RP ELKINS, KL (reprint author), US FDA,CTR BIOL EVALUAT & RES,DIV BACTERIAL PROD,ENTER & SEXUALY TRANSMITTED DIS LAB,BETHESDA,MD 20852, USA. NR 48 TC 28 Z9 29 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 1043-0342 J9 HUM GENE THER JI Hum. Gene Ther. PD JUL PY 1994 VL 5 IS 7 BP 809 EP 820 DI 10.1089/hum.1994.5.7-809 PG 12 WC Biotechnology & Applied Microbiology; Genetics & Heredity; Medicine, Research & Experimental SC Biotechnology & Applied Microbiology; Genetics & Heredity; Research & Experimental Medicine GA NY715 UT WOS:A1994NY71500004 PM 7981307 ER PT J AU APOSTOLAKIS, PJ MIDDLETON, JR SCHERRER, D FENG, M LEPORE, AN AF APOSTOLAKIS, PJ MIDDLETON, JR SCHERRER, D FENG, M LEPORE, AN TI NOISE PERFORMANCE OF LOW-POWER 0.25 MICRON GATE ION-IMPLANTED D-MODE GAAS-MESFET FOR WIRELESS APPLICATIONS SO IEEE ELECTRON DEVICE LETTERS LA English DT Article ID BAND AB We report on the noise performance of low power 0.25 mum gate ion implanted D-mode GaAs MESFETs suitable for wireless personal communication applications. The 0.25 mum x 200 mum D-mode MESFET has a f(t) of 18 GHz and f(max) of 33 GHz at a power level of 1 mW (power density of 5 mW/mm). The noise characteristics at 4 GHz for the D-mode MESFET are F(min) = 0.65 dB and G(assoc) = 13 dB at 1 mW. These results demonstrate that the GaAs D-mode MESFET is also an excellent choice for low power personal communication applications. C1 USA,RES LAB,ELECTR & POWER SYST DIRECTORATE,FT MONMOUTH,NJ 07703. RP APOSTOLAKIS, PJ (reprint author), UNIV ILLINOIS,CTR COMPOUND SEMICOND MICROELECTR,DEPT ELECT & COMP ENGN,URBANA,IL 61801, USA. NR 8 TC 0 Z9 0 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0741-3106 J9 IEEE ELECTR DEVICE L JI IEEE Electron Device Lett. PD JUL PY 1994 VL 15 IS 7 BP 239 EP 241 DI 10.1109/55.294082 PG 3 WC Engineering, Electrical & Electronic SC Engineering GA NV249 UT WOS:A1994NV24900003 ER PT J AU PAOLELLA, A MADJAR, A HERCZFELD, PR AF PAOLELLA, A MADJAR, A HERCZFELD, PR TI MODELING THE GAAS-MESFETS RESPONSE TO MODULATED LIGHT AT RADIO AND MICROWAVE-FREQUENCIES SO IEEE TRANSACTIONS ON MICROWAVE THEORY AND TECHNIQUES LA English DT Article ID FET AB In recent years, the usefulness of the MESFET as an optically sensitive microwave element on MMIC's has generated much interest. A theoretical model for the device under steady illumination has been developed previously by the authors. This paper presents an extension of that model to include sinusoidally modulated illumination up to the microwave range. The dependance of the response on the bias conditions, the wavelength, intensity and modulation frequency of the optical input, and the particulars of device structure are incorporated in the model. The importance of the internal photovoltaic effect, not properly accounted for in previous works, is emphasized. The theoretical model is validated by experimental results. C1 USA,RES LAB,FT MONMOUTH,NJ 07703. RP PAOLELLA, A (reprint author), DREXEL UNIV,CTR MICROWAVE LIGHTWAVE ENGN,PHILADELPHIA,PA 19104, USA. NR 12 TC 12 Z9 12 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9480 J9 IEEE T MICROW THEORY JI IEEE Trans. Microw. Theory Tech. PD JUL PY 1994 VL 42 IS 7 BP 1122 EP 1130 DI 10.1109/22.299746 PG 9 WC Engineering, Electrical & Electronic SC Engineering GA NZ278 UT WOS:A1994NZ27800003 ER PT J AU KOSINSKI, JA LU, YC BALLATO, A AF KOSINSKI, JA LU, YC BALLATO, A TI PURE-MODE MEASUREMENTS OF LI2B4O7 MATERIAL PROPERTIES SO IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL LA English DT Article ID LITHIUM TETRABORATE; TEMPERATURE; CRYSTAL; RESONATORS; PRESSURE; GROWTH AB Recent measurements of doubly rotated plate resonators have highlighted the need for more accurate material constants for use in dilithium tetraborate resonator design. In this paper, we report on the room-temperature determination of the elastic, piezoelectric, and dielectric constants of dilithium tetraborate using frequency domain measurements of primarily pure-mode vibrations in thin, flat plates. C1 RUTGERS STATE UNIV,DEPT ELECT & COMP ENGN,PISCATAWAY,NJ 08855. RP KOSINSKI, JA (reprint author), USA,RES LAB,FT MONMOUTH,NJ 07703, USA. NR 55 TC 6 Z9 7 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0885-3010 J9 IEEE T ULTRASON FERR JI IEEE Trans. Ultrason. Ferroelectr. Freq. Control PD JUL PY 1994 VL 41 IS 4 BP 473 EP 478 DI 10.1109/58.294107 PG 6 WC Acoustics; Engineering, Electrical & Electronic SC Acoustics; Engineering GA NV882 UT WOS:A1994NV88200009 ER PT J AU YAMAMOTO, T KANEKO, M CHANGCHAWALIT, S SERICHANTALERGS, O IJUIN, S ECHEVERRIA, P AF YAMAMOTO, T KANEKO, M CHANGCHAWALIT, S SERICHANTALERGS, O IJUIN, S ECHEVERRIA, P TI ACTIN ACCUMULATION ASSOCIATED WITH CLUSTERED AND LOCALIZED ADHERENCE IN ESCHERICHIA-COLI ISOLATED FROM PATIENTS WITH DIARRHEA SO INFECTION AND IMMUNITY LA English DT Article ID PLASMID-MEDIATED FACTORS; TISSUE-CULTURE CELLS; HEP-2 CELLS; DIFFUSE ADHERENCE; EAE GENE; DNA PROBE; NUCLEOTIDE-SEQUENCE; DIAGNOSTIC-TEST; HELA-CELLS; PATTERNS AB Escherichia coli D2 (serotype 07:H-) that was isolated from a child with diarrhea hybridized with an F1845 DNA probe used to detect diffuse adherence. Strain D2 adhered to tissue culture cells (HeLa and HEp-2 cells) in a clustered pattern but did not autoagglutinate on the cell surface and induced the elongation of microvilli after 3 h of incubation. After 6 h of incubation, the infected cells were positive for fluorescent-actin staining at the site of clustered adherence. When analyzed with a confocal laser scanning microscope, each D2 cell was surrounded by accumulated actin in a capsule-like formation. Capsule-like, accumulated actin was also observed with enteropathogenic E. coli (EPEC), although in this case, actin accumulation was associated with EPEC microcolonies in a localized pattern. Four other strains of F1845 DNA probe-positive, diffusely adhering E. Coli were negative for actin accumulation. Strain D2 did not hybridize with EPEC attaching and effacing DNA or EPEC adherence factor DNA probes. In addition, clustered D2 cells were found inside tissue culture cells. The data suggest a novel infectious mechanism as well as genetic heterogeneity of F1845 DNA probe-positive E. coli, Capsule like, accumulated actin may protect the bacteria from host defense mechanisms. C1 ARMED FORCES RES INST MED SCI,DEPT BACTERIOL IMMUNOL & MOLEC GENET,BANGKOK 10400,THAILAND. RP YAMAMOTO, T (reprint author), JUNTENDO UNIV,SCH MED,DEPT BACTERIOL,BUNKYO KU,2-1-1 HONGO,TOKYO 113,JAPAN. NR 56 TC 27 Z9 27 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD JUL PY 1994 VL 62 IS 7 BP 2917 EP 2929 PG 13 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA NU014 UT WOS:A1994NU01400035 PM 8005680 ER PT J AU BHATNAGAR, R FRIEDLANDER, AM AF BHATNAGAR, R FRIEDLANDER, AM TI PROTEIN-SYNTHESIS IS REQUIRED FOR EXPRESSION OF ANTHRAX LETHAL TOXIN CYTOTOXICITY SO INFECTION AND IMMUNITY LA English DT Article ID PROTECTIVE ANTIGEN; BACILLUS-ANTHRACIS; EUKARYOTIC RIBOSOMES; ADENYLATE-CYCLASE; CELLS; RICIN; INHIBITORS; MECHANISM; SURFACE AB Anthrax lethal toxin, which is composed of two proteins, i.e., protective antigen and lethal factor, is cytolytic to mouse peritoneal macrophages and the macrophage-like cell line J774A.1. After exposure of cells to lethal toxin, inhibition of protein synthesis occurred only slightly before the onset of cytolysis. Thus, cell death did not appear to be due to inhibition of protein synthesis. However, prior treatment of J774A.1 cells with cycloheximide or puromycin, which inhibited protein synthesis, protected them completely against lethal toxin-induced cytolysis, which suggested that continuous protein synthesis is required for the expression of lethal toxin activity. Inhibition of protein synthesis had no appreciable effect on the binding of protective antigen to the cell surface receptor or on proteolytic cleavage of surface-bound protective antigen. Furthermore, inhibition of protein synthesis did not alter the uptake of toxin, which suggested that protein synthesis is required at a later stage of the intoxication process. The protection provided by inhibition of protein synthesis was effective, even up to 1 h after exposure to anthrax lethal toxin. The increased uptake of calcium observed in cells exposed to lethal toxin did not occur when they were protected by blocking protein synthesis. Identifying the protein(s) synthesized during the intoxication process may help to understand the mechanism of cell death produced by anthrax lethal toxin. C1 USA,MED RES INST INFECT DIS,FREDERICK,MD 21702. NR 27 TC 40 Z9 41 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD JUL PY 1994 VL 62 IS 7 BP 2958 EP 2962 PG 5 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA NU014 UT WOS:A1994NU01400040 PM 8005682 ER PT J AU LOW, LL RIPPLE, GR BRUDERER, BP HARRINGTON, GR AF LOW, LL RIPPLE, GR BRUDERER, BP HARRINGTON, GR TI NONOPERATIVE MANAGEMENT OF GASTRIC PERFORATION SECONDARY TO CARDIOPULMONARY-RESUSCITATION SO INTENSIVE CARE MEDICINE LA English DT Note DE CARDIOPULMONARY RESUSCITATION; GASTRIC PERFORATION; NONOPERATIVE MANAGEMENT; PNEUMOPERITONEUM; CORONARY ARTERY DISEASE; CRITICAL CARE ID RUPTURE AB We report the case of a 72-year-old male who suffered a cardiac arrest during an early positive treadmill stress test. After successful resuscitation the patient had evidence of a gastric perforation. Because of his hemodynamic stability, lack of peritoneal signs, and prohibitively high surgical risk, a non-operative management approach was successfully administered. Although not the standard approach to traumatic gastric perforation, this case is not unlike the management of peptic ulcer perforations. A non-operative approach should be considered as an option in selected patients. C1 WALTER REED ARMY MED CTR,DEPT SURG,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT MED,CRIT CARE MED SERV,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT MED,PULM & CRIT CARE MED SERV,WASHINGTON,DC 20307. NR 10 TC 5 Z9 5 U1 0 U2 0 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0342-4642 J9 INTENS CARE MED JI Intensive Care Med. PD JUL PY 1994 VL 20 IS 6 BP 442 EP 443 DI 10.1007/BF01710656 PG 2 WC Critical Care Medicine SC General & Internal Medicine GA PA617 UT WOS:A1994PA61700010 PM 7798450 ER PT J AU RHODES, DL CUMMINGS, MT TEMPEL, GF AF RHODES, DL CUMMINGS, MT TEMPEL, GF TI APPLICATION OF FAULT MODELING TO CONTINUOUS BUILT-IN-TEST (C-BIT) FOR MICROWAVE AND MMIC CIRCUITS SO INTERNATIONAL JOURNAL OF MICROWAVE AND MILLIMETER-WAVE COMPUTER-AIDED ENGINEERING LA English DT Article ID ANALOG CIRCUITS; DIAGNOSIS; SYSTEMS; DIAGNOSABILITY; TESTABILITY; LOCATION AB A simulation-before-test method has been applied to the linear and nonlinear microwave built-in test (BIT) problem. Fault simulation via a harmonic balance simulator is used to analyze and optimize BIT hardware placement based on figures of merit such as fault coverage, ambiguity size, and part isolation. Fault models for a prototype microwave mini-system were developed along with models for the BIT hardware itself. The search method developed to automate the placement of BIT hardware is an essential design-for-test tool. The techniques developed were applied to an example system and results are given. (C) 1994 John Wiley & Sons, Inc.* C1 GEO CTR,EATONTOWN,NJ 07724. RP RHODES, DL (reprint author), USA,RES LAB,ELECTR & POWER SOURCES DIRECTORATE,AMSRL,EP,MA,FT MONMOUTH,NJ 07703, USA. NR 34 TC 0 Z9 0 U1 0 U2 0 PU JOHN WILEY & SONS INC PI NEW YORK PA 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 1050-1827 J9 INT J MICROWAVE MILL JI Int. J. Microw. Millimeter-Wave Comput.-Aided Eng. PD JUL PY 1994 VL 4 IS 3 BP 259 EP 271 DI 10.1002/mmce.4570040306 PG 13 WC Computer Science, Interdisciplinary Applications; Engineering, Electrical & Electronic SC Computer Science; Engineering GA NT194 UT WOS:A1994NT19400005 ER PT J AU ROSE, DN BRYK, DC ARUTUNIAN, G DUMAR, JE SLAVIN, MJ AF ROSE, DN BRYK, DC ARUTUNIAN, G DUMAR, JE SLAVIN, MJ TI PHOTOACOUSTIC MICROSCOPY OF INDENTATION LATERAL CRACKS SO JOURNAL DE PHYSIQUE IV LA English DT Article; Proceedings Paper CT 8th International Topical Meeting on Photoacoustic and Photothermal Phenomena (8 ITMP) CY JAN 22-25, 1994 CL POINTE A PITRE, GUADELOUPE SP UNIV PIERRE & MARIE CURIE, CNRS, ECOLE SUPER PHYS & CHIM IND VILLE PARIS ID FRACTURE-TOUGHNESS; CLOSED CRACKS; CERAMICS; SOLIDS AB Understanding the fracture process in advanced ceramics is of obvious use for improving their strength, toughness and ultimately performance. The lateral cracking process is related to wear in particular. Photoacoustic microscopy is used here to view lateral cracks produced in a controlled manner by Vicker's indentations in hot pressed silicon nitride (NC 132, Norton Co.). Eventually, a figure of merit related to bearing performance may emerge. C1 USA,RES LAB,AMSRL,MA,CA,WATERTOWN,MA 02172. RP ROSE, DN (reprint author), USA,TANK AUTOMOT COMMAND,AMSTA,JA,WARREN,MI 48397, USA. NR 17 TC 7 Z9 7 U1 0 U2 2 PU EDITIONS PHYSIQUE PI LES ULIS CEDEX PA Z I DE COURTABOEUF AVE 7 AV DU HOGGAR, BP 112, 91944 LES ULIS CEDEX, FRANCE SN 1155-4339 J9 J PHYS IV JI J. Phys. IV PD JUL PY 1994 VL 4 IS C7 BP 599 EP 602 DI 10.1051/jp4:19947141 PG 4 WC Physics, Multidisciplinary SC Physics GA PR168 UT WOS:A1994PR16800142 ER PT J AU HUSS, RW HUSS, K SQUIRE, EN CARPENTER, GB SMITH, LJ SALATA, K HERSHEY, J AF HUSS, RW HUSS, K SQUIRE, EN CARPENTER, GB SMITH, LJ SALATA, K HERSHEY, J TI MITE ALLERGEN CONTROL WITH ACARICIDE FAILS SO JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY LA English DT Article DE ACARICIDE; MITE ALLERGY; ASTHMA; ALLERGEN; HOME VISITS; AVOIDANCE; RESPIRATORY STATUS ID DUST MITE; HOUSE DUST; BENZYL BENZOATE; ASTHMA; MANAGEMENT; AVOIDANCE; CHILDREN; TRIAL AB Background: We compared the effects of an acaricide, benzyl benzoate, with the effects of baking soda control applied to bedroom and living room carpets on house dust mite allergen levels, lung function, and medication use in 12 adult patients with asthma for it months. Methods: This was a randomized, double-blind placebo-controlled study. Patients were enrolled from the allergy clinic of a large tertiary care center in a metropolitan area. All patients had positive dust mite puncture test results. Sir patients used benzyl benzoate, and sir used baking soda. Other aggressive mite control measures were implemented uniformly in each group. Subjects were to make two carpet applications, at baseline and at 6 months according to the manufacturer's recommendations. Dust samples were collected in bedroom and living room carpets at 0 3, 6, 9, and 12 months; and quantities of Der p I and Der f I allergens were determined Spirometry was done every 3 months, and peak flow rates were recorded for to days after each dust sampling. Results: There were no significant differences in mean allergen levels between the two groups over time at either site. There were no significant changes in lung function or medication use for either group. Conclusions: Benzyl benzoate powder applications may not be effective when done according to manufacturer's instructions. Further studies are necessary to test effectiveness when applied more frequently and for longer periods. C1 WALTER REED ARMY MED CTR,ALLERGY IMMUNOL SERV,WASHINGTON,DC 20307. JOHNS HOPKINS UNIV,CTR NURSING RES,BALTIMORE,MD. NR 16 TC 40 Z9 41 U1 0 U2 2 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0091-6749 J9 J ALLERGY CLIN IMMUN JI J. Allergy Clin. Immunol. PD JUL PY 1994 VL 94 IS 1 BP 27 EP 32 DI 10.1016/0091-6749(94)90067-1 PG 6 WC Allergy; Immunology SC Allergy; Immunology GA NX393 UT WOS:A1994NX39300004 PM 8027495 ER PT J AU YOUNG, RJ BODT, BA AF YOUNG, RJ BODT, BA TI DEVELOPMENT OF COMPUTER-DIRECTED METHODS FOR THE IDENTIFICATION OF HYPERACTIVATED MOTION USING MOTION PATTERNS DEVELOPED BY RABBIT SPERM DURING INCUBATION UNDER CAPACITATION CONDITIONS SO JOURNAL OF ANDROLOGY LA English DT Article DE HYPERACTIVATED MOTILITY; MULTIVARIATE DISCRIMINANT; ANALYSIS; CART(TM); CLASSIFICATION; MODELING ID GUINEA-PIG SPERMATOZOA; MOVEMENT CHARACTERISTICS; MOTILITY PATTERNS; EPIDIDYMAL SPERMATOZOA; INVITRO CAPACITATION; FERTILIZING ABILITY; ASSAY; ACTIVATION; OVIDUCTS; TIME AB Rabbit spermatozoa developed motions that mimicked hyperactivated motility during incubation for 16-20 hours under capacitation conditions and in several other commonly used media. Sperm from some rabbits failed to acquire this type of motility, and sperm from others failed to survive the long incubation time. Four motility patterns developed during incubation for 16-20 hours. Motility parameters measured by the CellSoft and CellTrak motion analysis systems were similar except for the average amplitude of lateral head displacement. Multivariate discriminant analysis with complementary regression analysis, and an unrelated tree structured classification method (CART(TM)), were used to derive rules, based on motility parameters, for the objective classification of sperm into the two motility classes: 1) nonhyperactivated motility and 2) hyperactivated motility or motility that mimicked hyperactivated motility. The motility parameter wobble (WOB) was superior to the commonly used parameter, linearity, as a classifier of motility types. It classified sperm into the two motility groups with 96.6% efficiency and, together with curvilinear velocity (VCL), attained classification efficiencies of 98%. The classification model produced by CART was preferred over the one obtained by discriminant analysis. The rule for motility classification was dependent on the motion analysis system used to measure the motion parameters. The rule for the CellSoft system, WOB less than or equal to 0.78 and VCL greater than or equal to 51 mu m/second, classified sperm with an efficiency of 98%, whereas the rule for the CellTrak system, WOB less than or equal to 0.69 and VCL greater than or equal to 55 mu m/second, achieved a classification efficiency of 97%. These rules should facilitate the study of sperm hyperactivation and its role in sperm function. C1 USA,RES LAB,ABERDEEN PROVING GROUND,MD. RP YOUNG, RJ (reprint author), EDGEWOOD RES DEV & ENGN CTR,SCBDR,RTL,DEPT LIFE SCI,ABERDEEN PROVING GROUND,MD 21010, USA. NR 51 TC 13 Z9 13 U1 0 U2 0 PU AMER SOC ANDROLOGY, INC PI LAWRENCE PA C/O ALLEN PRESS, INC PO BOX 368, LAWRENCE, KS 66044 SN 0196-3635 J9 J ANDROL JI J. Androl. PD JUL-AUG PY 1994 VL 15 IS 4 BP 362 EP 377 PG 16 WC Andrology SC Endocrinology & Metabolism GA PC122 UT WOS:A1994PC12200013 PM 7982805 ER PT J AU LEE, PCY YANG, JS BALLATO, A AF LEE, PCY YANG, JS BALLATO, A TI STRESS SENSITIVITY OF RESONANCES OF TRANSVERSE ELECTRIC MODES IN CIRCULAR DISK DIELECTRIC RESONATORS SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID VIBRATIONS; PLATES AB Two-dimensional governing equations for guided electromagnetic waves in isotropic or cubic crystal dielectric plates are extended to include the piezo-optic effect in the constitutive equations. These equations are then employed to study the frequency shifts of transverse electric modes caused by stresses in circular disk dielectric resonators under three cases of loading conditions: (1) a pair of diametral forces, (2) steady vertical acceleration, and (3) steady horizontal acceleration. In the latter two cases, the bottom face of the disk is bounded to a rigid supporting base. C1 USA,RES LAB,FT MONMOUTH,NJ 07703. RP LEE, PCY (reprint author), PRINCETON UNIV,DEPT CIVIL ENON & OPERAT RES,PRINCETON,NJ 08544, USA. NR 14 TC 2 Z9 2 U1 0 U2 1 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD JUL 1 PY 1994 VL 76 IS 1 BP 63 EP 72 DI 10.1063/1.357061 PG 10 WC Physics, Applied SC Physics GA NW318 UT WOS:A1994NW31800007 ER PT J AU ANZUETO, A BRASSARD, JM ANDRADE, FH LAWRENCE, RA MAXWELL, LC LEVINE, SM JENKINSON, SG AF ANZUETO, A BRASSARD, JM ANDRADE, FH LAWRENCE, RA MAXWELL, LC LEVINE, SM JENKINSON, SG TI EFFECTS OF HYPEROXIA ON RAT DIAPHRAGM FUNCTION SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE FATIGUE; RESPIRATORY MUSCLES; FREE RADICALS; RESISTIVE BREATHING; GLUTATHIONE; CONTRACTILE PROPERTIES ID OXYGEN-TOXICITY; SKELETAL-MUSCLE; REACTIVE OXYGEN; BLOOD-FLOW; FATIGUE; GLUTATHIONE; LUNG; PERFORMANCE; 100-PERCENT AB The association of oxygen radical generation with impaired diaphragm performance has previously been reported after inspiratory resistive loading (IRL). We hypothesized that exposure of rats to normobaric hyperoxia (O-2) could produce impaired diaphragm function because of free radical production. Sprague-Dawley rats were divided into four groups: 1) room air (control), 2) > 95% O-2 for 24 h, 3) > 95% O-2 for 48 h, and 4) > 95% O-2 for 60 h. Each group was studied at rest after the O-2 exposure and then after IRL. During IRL, the animals breathed through an inspiratory resistor until they were unable to sustain > 70% of the maximum airway pressure. Diaphragm samples were obtained for analysis of glutathione (GSH) and glutathione disulfide (GSSG) concentrations. In vitro isometric contractile properties were also determined, including maximal tetanic tension (P-o) and maximal twitch tension (P-t), in GSSG content and in GSSG-to-GSH ratios. Hyperoxia for > 48 h resulted in significant decreases in P-o and P-t and an increase in GSSG content and in GSSG-to-GSH ratios compared with other groups. Those same animals subjected to IRL showed a further decrease in P-o and P-t. These data suggest that free radical generation may occur in the diaphragm during a hyperoxia exposure associated with activation of the GSH redox cycle and impairment of diaphragm function. C1 UNIV TEXAS,HLTH SCI CTR,DEPT MED,DIV PULM DIS CRIT CARE,SAN ANTONIO,TX 78284. UNIV TEXAS,HLTH SCI CTR,DEPT PHYSIOL,DIV PULM DIS CRIT CARE,SAN ANTONIO,TX 78284. BROOKE ARMY MED CTR,SAN ANTONIO,TX 78284. RP ANZUETO, A (reprint author), AUDIE L MURPHY MEM VET ADM MED CTR,DIV PULM DIS CRIT CARE 111E,7400 MERTON MINTER BLVD,SAN ANTONIO,TX 78284, USA. RI Andrade, Francisco/F-1258-2011 OI Andrade, Francisco/0000-0002-2460-5798 FU NHLBI NIH HHS [HL-32824] NR 31 TC 8 Z9 8 U1 0 U2 0 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 8750-7587 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD JUL PY 1994 VL 77 IS 1 BP 63 EP 68 PG 6 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA NX536 UT WOS:A1994NX53600011 PM 7961276 ER PT J AU FULCO, CS CYMERMAN, A MUZA, SR ROCK, PB PANDOLF, KB LEWIS, SF AF FULCO, CS CYMERMAN, A MUZA, SR ROCK, PB PANDOLF, KB LEWIS, SF TI ADDUCTOR POLLICIS MUSCLE FATIGUE DURING ACUTE AND CHRONIC ALTITUDE EXPOSURE AND RETURN TO SEA-LEVEL SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE HYPOXIA; MUSCLE STRENGTH; STATIC CONTRACTION ID SKELETAL-MUSCLE; EXERCISE; PERFORMANCE; HYPOXIA; CONTRACTION; CALCIUM; PH AB Large muscle exercise performance is impaired during acute exposure to normobaric or hypobaric hypoxia, but the effects of hypoxic conditions on fatigue of isolated smaller muscle groups per se are poorly defined. We studied how acute and chronic altitude (ALT) exposure and post-ALT return to sea level (SL) affects voluntary strength and fatigue of the adductor pollicis muscle. Eight healthy men (mean age 28 yr) were studied on five separate occasions: at SL, on days 1 (acute) and 13 (chronic) at ALT (4,300 m), and on days 1 (post 1) and 3 or 4 (post 2) at SL after 20 days of residence at ALT. On each day, maximal voluntary contractions (MVCs) of the adductor pollicis were obtained before and at the end of each minute of submaximal intermittent contractions of the adductor pollicis (50% of MVC of rested muscle, 5 s of contraction/5 s of rest) until exhaustion, defined as the inability to exert or maintain 50% of rested MVC. MVC of rested muscle did not differ among days. Time to exhaustion was shorter at acute ALT [5.1 +/- 0.5 (SE) min] than at SL (7.4 +/- 0.8 min, P < 0.05) and tended to be shorter than at chronic ALT (6.6 +/- 0.7 min, P > 0.05). Compared with acute and chronic ALT, time to exhaustion was prolonged during post 1 (9.0 +/- 1.2 min, P < 0.05) but not post 2 (6.1 +/- 0.5 min, P > 0.05). We conclude that 1) MVC of rested adductor pollicis muscle is not impaired during or after ALT exposure, 2) compared with SL conditions, acute but not chronic ALT exposure leads to a more rapid decline in adductor pollicis MVC associated with submaximal contractions, and 3) time to exhaustion is prolonged for greater than or equal to 1 day after return from ALT. C1 BOSTON UNIV,SARGENT COLL ALLIED HLTH PROFESS,DEPT HLTH SCI,BOSTON,MA 02215. RP FULCO, CS (reprint author), USA,ENVIRONM MED RES INST,ENVIRONM PHYSIOL & MED DIRECTORATE,DIV ALTITUDE PHYSIOL & MED,NATICK,MA 01760, USA. NR 31 TC 46 Z9 46 U1 2 U2 5 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 8750-7587 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD JUL PY 1994 VL 77 IS 1 BP 179 EP 183 PG 5 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA NX536 UT WOS:A1994NX53600027 PM 7961231 ER PT J AU MONTAIN, SJ SAWKA, MN CADARETTE, BS QUIGLEY, MD MCKAY, JM AF MONTAIN, SJ SAWKA, MN CADARETTE, BS QUIGLEY, MD MCKAY, JM TI PHYSIOLOGICAL TOLERANCE TO UNCOMPENSABLE HEAT-STRESS - EFFECTS OF EXERCISE INTENSITY, PROTECTIVE CLOTHING, AND CLIMATE SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE HEAT EXHAUSTION; TEMPERATURE REGULATION ID HUMID ENVIRONMENTS; STRAIN; PERFORMANCE; WORK; HOT AB This study determined the influence of exercise intensity, protective clothing level, and climate on physiological tolerance to uncompensable heat stress. It also compared the relationship between core temperature and the incidence of exhaustion from heat strain for persons wearing protective clothing to previously published data of unclothed persons during uncompensable heat stress. Seven heat-acclimated men attempted 180-min treadmill walks at metabolic rates of similar to 425 and 600 W while wearing full (do = 1.5) or par tial (do = 1.3) protective clothing in both a desert (43 degrees C dry bulb, 20% relative humidity, wind 2.2 m/s) and tropical (35 degrees C dry bulb, 50% relative humidity, wind 2.2 m/s) climate. During these trials, the evaporative cooling required to maintain thermal balance exceeded the maximal evaporative capacity of the environment and core temperature continued to rise until exhaustion from heat strain occurred. Our findings concerning exhaustion from heat strain are 1) full encapsulation in protective clothing reduces physiological tolerance as core temperature at exhaustion was lower (P < 0.05) in fully than in partially clothed persons, 2) partial encapsulation results in physiological tolerance similar to that reported for unclothed persons, 3) raising metabolic rate from 400 to 600 W does not alter physiological tolerance when subjects are fully clothed, and 4) physiological tolerance is similar when subjects are wearing protective clothing in desert and tropical climates having the same wet bulb globe thermometer. These findings can improve occupational safety guidelines for human heat exposure, as they provide further evidence that the incidence of exhaustion from heat strain can be predicted from core temperature. RP MONTAIN, SJ (reprint author), USA,ENVIRONM MED RES INST,DIV THERMAL PHYSIOL & MED,5 KANSAS ST,NATICK,MA 01760, USA. NR 28 TC 123 Z9 129 U1 0 U2 19 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 8750-7587 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD JUL PY 1994 VL 77 IS 1 BP 216 EP 222 PG 7 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA NX536 UT WOS:A1994NX53600033 PM 7961236 ER PT J AU STAFFORD, RG HINES, HB AF STAFFORD, RG HINES, HB TI METHOD FOR THE IDENTIFICATION OF SAXITOXIN IN RAT URINE SO JOURNAL OF CHROMATOGRAPHY B-BIOMEDICAL APPLICATIONS LA English DT Article ID PRECHROMATOGRAPHIC OXIDATION; PSP TOXINS; SHELLFISH; TRANSFORMATION AB Saxitoxin (STX) is one of several related toxins that cause paralytic shellfish poisoning. We used solid-phase extraction (SPE) and prechromatographic oxidation/HPLC with fluorescence detection to isolate, identify, and quantify STX in rat urine. STX recovery from urine with the SPE procedure was approximately 76 +/- 6.5%. The standard curve was linear between 2 and 50 ng/ml. The lower limit of quantification with the method was 2 ng STX/ml of rat urine. Preliminary results with i.v. administration of STX to rats demonstrated that this method can detect and quantify STX in urine. RP STAFFORD, RG (reprint author), USA,MED RES INST INFECT DIS,DIV TOXICOL,FREDERICK,MD 21702, USA. NR 18 TC 9 Z9 9 U1 0 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-4347 J9 J CHROMATOGR B JI J. Chromatogr. B-Biomed. Appl. PD JUL 1 PY 1994 VL 657 IS 1 BP 119 EP 124 DI 10.1016/0378-4347(94)80077-4 PG 6 WC Biochemical Research Methods; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA NW846 UT WOS:A1994NW84600016 PM 7952057 ER PT J AU HANSON, CM BASCO, R AGAHI, F LAU, KM LAREAU, RT MONAHAN, TP AF HANSON, CM BASCO, R AGAHI, F LAU, KM LAREAU, RT MONAHAN, TP TI COMPOSITIONAL INHOMOGENEITY AT THE EPITAXIAL LAYER AND SUBSTRATE INTERFACE OF ALGAAS/GAAS HETEROSTRUCTURES SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article DE ALGAAS/GAAS; EPILAYER SUBSTRATE INTERFACE; LOW PRESSURE ORGANOMETALLIC VAPOR PHASE EPITAXY ID 2-DIMENSIONAL ELECTRON-GAS; CHEMICAL VAPOR-DEPOSITION; ALXGA1-XAS/GAAS HETEROSTRUCTURES; QUANTUM-WELLS; OMVPE AB Carrier concentration spikes at the epilayer/substrate interface were observed in some two-dimensional electron gas AlGaAs/GaAs structures grown by low pressure organometallic vapor phase epitaxy. Using secondary ion mass spectroscopy, the carrier spikes were correlated with indium. Under certain growth conditions an anomalous interfacial layer, which is compositionally inhomogeneous, is formed producing an enhanced carrier density. Procedures are described which reduce the presence of indium at the epilayer/substrate interface and eliminate the carrier spike. C1 USA,RES LAB,ELECTR & POWER SOURCES DIRECTORATE,FT MONMOUTH,NJ 07703. UNIV MASSACHUSETTS,DEPT ELECT & COMP ENGN,AMHERST,MA 01003. RP HANSON, CM (reprint author), USN,CTR COMMAND CONTROL OCEAN SURVEILLANCE,RDTE DIV 555,SAN DIEGO,CA 92152, USA. NR 15 TC 0 Z9 0 U1 0 U2 0 PU MINERALS METALS MATERIALS SOC PI WARRENDALE PA 420 COMMONWEALTH DR, WARRENDALE, PA 15086 SN 0361-5235 J9 J ELECTRON MATER JI J. Electron. Mater. PD JUL PY 1994 VL 23 IS 7 BP 649 EP 652 DI 10.1007/BF02653351 PG 4 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA NW061 UT WOS:A1994NW06100010 ER PT J AU COUSINS, WT DALTON, KK ANDERSEN, TT BOBULA, GA AF COUSINS, WT DALTON, KK ANDERSEN, TT BOBULA, GA TI PRESSURE AND TEMPERATURE DISTORTION TESTING OF A 2-STAGE CENTRIFUGAL-COMPRESSOR SO JOURNAL OF ENGINEERING FOR GAS TURBINES AND POWER-TRANSACTIONS OF THE ASME LA English DT Article; Proceedings Paper CT 38th International Gas Turbine and Aeroengine Congress and Exposition CY MAY 24-27, 1993 CL CINCINNATI, OH SP INT GAS TURBINE INST AB Altitude pressure and temperature inlet distortion testing of the two-stage centrifugal compressor in the T800-LHT-800 engine is described. The test setup and the testing techniques are reviewed and the results of the test are presented. The generation of classical 180 deg patterns of both pressure and temperature distortion is discussed. Temperature distortion was created using a hydrogen burner system while pressure distortion was created in the classical manner, using screens. Results of both individual and combined temperature and pressure distortions in both opposed and concurrent patterns are shown. C1 USA,VEHICLE PROPULS DIRECTORATE,RES LAB,CLEVELAND,OH 44135. RP COUSINS, WT (reprint author), ALLIEDSIGNAL ENGINES,PERFORMANCE & OPERABIL,PHOENIX,AZ 85010, USA. NR 5 TC 1 Z9 1 U1 1 U2 4 PU ASME-AMER SOC MECHANICAL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 SN 0742-4795 J9 J ENG GAS TURB POWER JI J. Eng. Gas. Turbines Power-Trans. ASME PD JUL PY 1994 VL 116 IS 3 BP 567 EP 573 DI 10.1115/1.2906857 PG 7 WC Engineering, Mechanical SC Engineering GA PA464 UT WOS:A1994PA46400016 ER PT J AU SEGUIN, MC KLOTZ, FW SCHNEIDER, I WEIR, JP GOODBARY, M SLAYTER, M RANEY, JJ ANIAGOLU, JU GREEN, SJ AF SEGUIN, MC KLOTZ, FW SCHNEIDER, I WEIR, JP GOODBARY, M SLAYTER, M RANEY, JJ ANIAGOLU, JU GREEN, SJ TI INDUCTION OF NITRIC-OXIDE SYNTHASE PROTECTS AGAINST MALARIA IN MICE EXPOSED TO IRRADIATED PLASMODIUM-BERGHEI-INFECTED MOSQUITOS - INVOLVEMENT OF INTERFERON-GAMMA AND CD8+ T-CELLS SO JOURNAL OF EXPERIMENTAL MEDICINE LA English DT Note ID CIRCUMSPOROZOITE PROTEIN; HEPATOCYTES; SPOROZOITES; MACROPHAGE; INHIBITION; EXPRESSION; PARASITES; RECOGNIZE; IMMUNITY; PATHWAY AB Exposure of BALB/c mice to mosquitoes infected with irradiated Plasmodium berghei confers protective immunity against subsequent sporozoite challenge. Immunized mice challenged with viable sporozoites develop parasitemia when treated orally with substrate inhibitors of nitric oxide synthase (NOS). This suggests that the production of nitric oxide (NO) prevents the development of exoerythrocytic stages of malaria in liver. Liver tissue from immunized mice expressed maximal levels of mRNA for inducible NOS (iNOS) between 12 and 24 h after challenge with sporozoites. Intraperitoneal injection of neutralizing monoclonal antibody against interferon gamma (IFN-gamma) or in vivo depletion of CD8(+) T cells, but not CD4(+) T cells, at the time of challenge blocked expression of iNOS mRNA and ablated protection in immunized mice. These results show that both CD8(+) T cells and IFN-gamma are important components in the regulation of iNOS in liver which contributes to the protective response of mice immunized with irradiated malaria sporozoites. IFN-gamma, likely provided by malaria-specific CD8(+) T cells, induces liver cells, hepatocytes and/or Kupffer cells, to produce NO for the destruction of infected hepatocytes or the parasite within these cells. C1 ENTREMED INC,ROCKVILLE,MD 20850. WALTER REED ARMY INST RES,DEPT IMMUNOL,DIV COMMUNICABLE DIS & IMMUNOL,WASHINGTON,DC 20307. WALTER REED ARMY INST RES,DEPT ENTOMOL,WASHINGTON,DC 20307. HENRY M JACKSON FDN ADVANCEMENT MIL MED,ROCKVILLE,MD 20850. ARMED FORCES INST PATHOL,WASHINGTON,DC 20306. NR 23 TC 152 Z9 157 U1 0 U2 1 PU ROCKEFELLER UNIV PRESS PI NEW YORK PA 1114 FIRST AVE, 4TH FL, NEW YORK, NY 10021 SN 0022-1007 J9 J EXP MED JI J. Exp. Med. PD JUL 1 PY 1994 VL 180 IS 1 BP 353 EP 358 DI 10.1084/jem.180.1.353 PG 6 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA NR989 UT WOS:A1994NR98900038 PM 7516412 ER PT J AU KLUTER, RA NATTRESS, DT DUNNE, CP POPPER, RD AF KLUTER, RA NATTRESS, DT DUNNE, CP POPPER, RD TI SHELF-LIFE EVALUATION OF CLING PEACHES IN RETORT POUCHES SO JOURNAL OF FOOD SCIENCE LA English DT Article DE PEACHES; RETORT POUCHES; SHELF LIFE; FLAVOR; TEXTURE AB Retort pouch sliced peaches in syrup were developed to replace freeze-dried peaches in a military field ration. Two processing variables were investigated: fruit source (fresh and frozen) and syrup pH (3.85 and 3.25). Peaches were stored at 4 degrees, 21 degrees and 38 degrees C and evaluated periodically by sensory panels and biochemical and instrumental analyses. pH had most effect on sensory color, texture and acceptability and instrumental color and sugar composition. High positive correlations existed between a factor (consisting of five sensory quality attributes) and sensory color and texture, Hunter L and a values and sucrose level. Frozen and fresh source peaches at pH 3.85 met shelflife requirements at 21 and 38 degrees. C1 OCEAN SPRAY CRANBERRIES INC,LAKEVILLE MIDDLEBORO,MA. RP KLUTER, RA (reprint author), USA,NATICK RES DEV & ENGN CTR,CONSUMER RES BRANCH,NATICK,MA 01760, USA. NR 17 TC 8 Z9 8 U1 1 U2 1 PU INST FOOD TECHNOLOGISTS PI CHICAGO PA SUITE 300 221 N LASALLE ST, CHICAGO, IL 60601-1291 SN 0022-1147 J9 J FOOD SCI JI J. Food Sci. PD JUL-AUG PY 1994 VL 59 IS 4 BP 849 EP & DI 10.1111/j.1365-2621.1994.tb08142.x PG 0 WC Food Science & Technology SC Food Science & Technology GA PG294 UT WOS:A1994PG29400039 ER PT J AU BAN, JD BENZINGER, E BUDOWLE, B DAVIS, L EISENBERG, AJ FOURNEY, RM HARTMANN, JM HERRIN, GL BARNA, CE BOWEN, JH BUEL, E DUNCAN, G FISH, P GRANT, TL HENRY, B JOHNSON, LM KAHN, R KONZAK, KC LONG, TM NARVESON, SD NEWALL, PJ POLLOCK, JM ROGERS, GS TAHIR, MA VONBEROLDINGEN, C KEARNEY, JJ LABER, TL MACLAREN, DC NELSON, MS PAGLIARO, E PRESLEY, LA SMETANA, CG TOMSEY, CS AF BAN, JD BENZINGER, E BUDOWLE, B DAVIS, L EISENBERG, AJ FOURNEY, RM HARTMANN, JM HERRIN, GL BARNA, CE BOWEN, JH BUEL, E DUNCAN, G FISH, P GRANT, TL HENRY, B JOHNSON, LM KAHN, R KONZAK, KC LONG, TM NARVESON, SD NEWALL, PJ POLLOCK, JM ROGERS, GS TAHIR, MA VONBEROLDINGEN, C KEARNEY, JJ LABER, TL MACLAREN, DC NELSON, MS PAGLIARO, E PRESLEY, LA SMETANA, CG TOMSEY, CS TI THE TECHNICAL-WORKING-GROUP-ON-DNA-ANALYSIS-METHODS (TWGDAM) CONSENSUS APPROACH FOR APPLYING THE CEILING PRINCIPLE TO DERIVE CONSERVATIVE ESTIMATES OF DNA PROFILE FREQUENCIES SO JOURNAL OF FORENSIC SCIENCES LA English DT Letter ID FIXED-BIN METHOD; TYPING DATA; STATISTICAL EVALUATION; FORENSIC APPLICATIONS; POPULATION-GENETICS; VNTR LOCI; FINGERPRINTS; NRC C1 ILLINOIS STATE POLICE, MAYWOOD, IL USA. FBI, FSRTC, QUANTICO, VA USA. UNIV N TEXAS, HLTH SCI CTR, FT WORTH, TX USA. GEORGIA BUR INVEST, DECATUR, GA USA. ROYAL CANADIAN MOUNTED POLICE, OTTAWA, ON, CANADA. BROWARD SHERIFFS OFF, FT LAUDERDALE, FL USA. CHICAGO POLICE DEPT, CHICAGO, IL USA. WASHOE CTY SHERIFFS OFF, RENO, NV USA. S CAROLINA LAW ENFORCEMENT DIV, COLUMBIA, SC USA. METRO DADE POLICE DEPT, MIAMI, FL USA. CALIF DEPT JUSTICE, BERKELEY, CA USA. ARIZONA DEPT PUBL SAFETY, PHOENIX, AZ USA. CTR FORENS SCI, TORONTO, ON, CANADA. FLORIDA DEPT LAW ENFORCEMENT, ORLANDO, FL USA. ALABAMA DEPT FORENS SCI, AUBURN, AL USA. OREGON STATE POLICE, CRIME LAB, SPRINGFIELD, OR USA. FBI, SCI ANAL SECT, WASHINGTON, DC USA. WASHINGTON STATE PATROL, CRIME LAB, SEATTLE, WA USA. CONNECTICUT STATE POLICE, FORENS SCI LAB, MERIDEN, CT USA. USA, CRIME LAB, WASHINGTON, DC 20310 USA. RP BAN, JD (reprint author), COMMONWEALTH VIRGINIA, DIV FORENS SCI, RICHMOND, VA 23261 USA. NR 37 TC 1 Z9 1 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0022-1198 EI 1556-4029 J9 J FORENSIC SCI JI J. Forensic Sci. PD JUL PY 1994 VL 39 IS 4 BP 899 EP 904 PG 6 WC Medicine, Legal SC Legal Medicine GA NY096 UT WOS:A1994NY09600001 ER PT J AU WANG, XH DONOVALOVA, J HOLLIS, A JOHNSON, D RODRIGUEZ, A KENNEDY, GD KRISHNAN, G BANKS, H AF WANG, XH DONOVALOVA, J HOLLIS, A JOHNSON, D RODRIGUEZ, A KENNEDY, GD KRISHNAN, G BANKS, H TI DIELS-ALDER REACTIVITY OF VINYLSULFOXYALLENES SO JOURNAL OF HETEROCYCLIC CHEMISTRY LA English DT Article ID ORGANIC-SYNTHESIS; DNA CLEAVAGE; NEOCARZINOSTATIN; VINYLALLENES; CARBONATES; OXIDATION; SULFONES; SYSTEMS; ROUTE; ACID AB Vinylsulfoxyallenes 3a-c are prepared from propargylic alcohols in 47-65% yield. Vinylsulfoxyallenes undergo facile [4+2] cycloadditions with methyl triazolidenedione (MTAD) and singlet oxygen to afford phenylsulfinylpyridazines and spirocyclic phenylsulfinyl-2H-pyran-3(6H)-ones in excellent yields (60-90%). Spirocyclic phenylsulfinyl-2H-pyran-3(6H)-ones are oxidized to the corresponding phenylsulfones with peracid or can be epoxidized with basic hydrogen peroxide. Spirocyclic pyranone formation is thought to proceed via the rearrangement of a labile cyclic peroxide intermediate 14. C1 GEORGIA STATE UNIV,LBCS,DEPT CHEM,ATLANTA,GA 30303. USA,EDGEWOOD RES DEV,CTR ENGN,ABERDEEN PROVING GROUND,MD 21010. RP WANG, XH (reprint author), CLARK ATLANTA UNIV,DEPT CHEM,ATLANTA,GA 30314, USA. NR 37 TC 9 Z9 9 U1 0 U2 0 PU HETERO CORPORATION PI TAMPA PA BOX 20285, TAMPA, FL 33622-0285 SN 0022-152X J9 J HETEROCYCLIC CHEM JI J. Heterocycl. Chem. PD JUL-AUG PY 1994 VL 31 IS 4 BP 871 EP 876 PG 6 WC Chemistry, Organic SC Chemistry GA PC127 UT WOS:A1994PC12700031 ER PT J AU KITROSSER, JH AF KITROSSER, JH TI AN EVALUATION OF A REGION-GROWING ALGORITHM PERFORMING DETECTION FOR AUTOMATIC TARGET RECOGNITION SO JOURNAL OF IMAGING SCIENCE AND TECHNOLOGY LA English DT Article AB A region growing algorithm that detects tactical ground vehicles was tested at the Night Vision and Electronic Sensors Directorate. Evaluation of test results on thermal imagery indicates that target-like objects separated from the background correlate well with ground-truth target locations. Furthermore, the algorithm produces data records associated with defined image regions. These records contain descriptive parameters that could be used for target classification. At high resolution, the internal regions of a target closely match specific cues that trained observers use when making classification decisions. Although the ultimate utility of a region growing technique has yet to be demonstrated fully, it does offer a novel approach to automatic target recognition. C1 USA,NIGHT VIS & ELECTR SENSORS DIRECTORATE,FT BELVOIR,VA 22060. NR 13 TC 3 Z9 3 U1 0 U2 0 PU I S & T - SOC IMAGING SCIENCE TECHNOLOGY PI SPRINGFIELD PA 7003 KILWORTH LANE, SPRINGFIELD, VA 22151 SN 8750-9237 J9 J IMAGING SCI TECHN JI J. Imaging Sci. Technol. PD JUL-AUG PY 1994 VL 38 IS 4 BP 311 EP 320 PG 10 WC Imaging Science & Photographic Technology SC Imaging Science & Photographic Technology GA PV023 UT WOS:A1994PV02300003 ER PT J AU VANCOTT, TC BETHKE, FR POLONIS, VR GORNY, MK ZOLLAPAZNER, S REDFIELD, RR BIRX, DL AF VANCOTT, TC BETHKE, FR POLONIS, VR GORNY, MK ZOLLAPAZNER, S REDFIELD, RR BIRX, DL TI DISSOCIATION RATE OF ANTIBODY-GP120 BINDING INTERACTIONS IS PREDICTIVE OF V3-MEDIATED NEUTRALIZATION OF HIV-1 SO JOURNAL OF IMMUNOLOGY LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; HUMAN MONOCLONAL-ANTIBODY; SURFACE-PLASMON RESONANCE; ENVELOPE GLYCOPROTEIN; MATERNAL ANTIBODIES; TYPE-1 GP120; VERTICAL TRANSMISSION; IMMOBILIZED ANTIGEN; SYNTHETIC PEPTIDE; ACID SEQUENCE AB mAbs specific for the V3 loop of HIV-1 are capable of neutralizing laboratory strains of HIV-1 in vitro. In this report we use surface plasmon resonance and biosensor technology to demonstrate that the ability of V3-specific mAbs to neutralize HIV-1(MN) correlated with the dissociation rate constant of the homologous mAb-gp120 binding interaction. mAbs capable of binding diverse strains of gp120 with similar association rate constants exhibited marked differences in the dissociation rate. The dissociation rate, and not the association rate, was found to be predictive of the neutralization capacity of the mAb. Furthermore, synthetic peptides corresponding to the V3 loop of HIV-1(IIIB, MN) yielded quantitatively similar binding kinetic profiles abrogating the need for purified recombinant gp120 protein and potentially facilitating the screening of more diverse isolates. Biosensor immobilized V3 peptides were found to mimic their conformational structure in solution. This offers advantages to peptides studied by ELISA where some degree of denaturation and masking of epitopes can occur upon adsorption of peptides to plastic surfaces. The impact of amino acid substitutions within epitopes on subsequent mAb binding was dissected by observing alterations in dissociation rates. The technique provides rapid kinetic analyses of V3 Ab binding interactions with diverse V3 sequences, facilitating the efficient screening and selection of those most likely to possess the broadest and most potent HIV-1 neutralizing potentials. C1 WALTER REED ARMY INST RES,DIV RETROVIROL,ROCKVILLE,MD 20850. HENRY M JACKSON FDN,ROCKVILLE,MD 20850. NYU,MED CTR,DEPT PATHOL,NEW YORK,NY 10016. VET AFFAIRS MED CTR,RES SERV,NEW YORK,NY 10010. VET AFFAIRS MED CTR,LAB SERV,NEW YORK,NY 10010. FU NIAID NIH HHS [AI32424] NR 67 TC 104 Z9 104 U1 0 U2 5 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD JUL 1 PY 1994 VL 153 IS 1 BP 449 EP 459 PG 11 WC Immunology SC Immunology GA NV228 UT WOS:A1994NV22800048 PM 7515931 ER PT J AU DHARAKUL, T KURANE, I BHAMARAPRAVATI, N YOKSAN, S VAUGHN, DW HOKE, CH ENNIS, FA AF DHARAKUL, T KURANE, I BHAMARAPRAVATI, N YOKSAN, S VAUGHN, DW HOKE, CH ENNIS, FA TI DENGUE VIRUS-SPECIFIC MEMORY T-CELL RESPONSES IN HUMAN VOLUNTEERS RECEIVING A LIVE ATTENUATED DENGUE VIRUS TYPE-2 CANDIDATE VACCINE SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID INTERFERON GAMMA-PRODUCTION; LYMPHOCYTES; INFECTIONS; CLONES; CD8 AB A live attenuated dengue virus type 2 candidate vaccine (16681-PDK53) was evaluated in a phase I trial in 10 nonimmune adult volunteers. The dengue virus-specific memory T cell responses were analyzed as part of this study. Dengue virus-specific T cell proliferative responses were observed in all subjects after stimulating their peripheral blood mononuclear cells with live viruses or noninfectious viral antigens. The highest proliferative response was against dengue virus type 2, although cross-reactivity with other flaviviruses was detected to a lesser degree in some subjects. Dengue virus type 2-specific CD4(+) and CD8(+) cytotoxic T lymphocytes were generated in all vaccinees. This study investigated whether the candidate vaccine was efficacious in inducing dengue virus-specific CD4(+) and CD8(+) T cell memory after a single immunization in nonimmune recipients. C1 UNIV MASSACHUSETTS,MED CTR,DEPT MED,DIV INFECT DIS & IMMUNOL,WORCESTER,MA 01655. MAHIDOL UNIV,SIRIRAJ HOSP,FAC MED,DEPT MICROBIOL,DIV IMMUNOL,BANGKOK,THAILAND. MAHIDOL UNIV,CTR VACCINE DEV,INST SCI & TECHNOL DEV,NAKHON PATHOM,THAILAND. WALTER REED ARMY INST RES,DEPT VIRUS DIS,WASHINGTON,DC. NR 11 TC 40 Z9 41 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD JUL PY 1994 VL 170 IS 1 BP 27 EP 33 PG 7 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA NR965 UT WOS:A1994NR96500005 PM 7912253 ER PT J AU SMOAK, BL NOVAKOSKI, WL MASON, CJ ERICKSON, RL AF SMOAK, BL NOVAKOSKI, WL MASON, CJ ERICKSON, RL TI EVIDENCE FOR A RECENT DECREASE IN MEASLES SUSCEPTIBILITY AMONG YOUNG AMERICAN ADULTS SO JOURNAL OF INFECTIOUS DISEASES LA English DT Note AB As part of an ongoing evaluation of US Army immunization policies, two serologic surveys were conducted at an army basic training center. Antibody status to measles, mumps, and rubella were determined by an ELISA in 969 soldiers in 1989 and 992 soldiers in 1990. Measles sero-negativity rates, directly adjusted to the 15- to 24-year-old US population in 1980, decreased from 21.3% in 1989 to 12.5% in 1990 (P <.001). Decreases also were observed in mumps(16.2% to 14.7%) and rubella seronegativity rates (18.4% to 14.3%) from 1989 to 1990 but were not statistically significant. In subgroup analyses, significant decreases in measles seronegativity were observed in younger, white, male, and female cohorts. There is evidence that susceptibility among young adults had declined, although it remains unclear if this is due to increased immunization or exposure to natural disease. RP SMOAK, BL (reprint author), WALTER REED ARMY INST RES,DIV PREVENT MED,WASHINGTON,DC 20307, USA. OI MASON, CARL/0000-0002-3676-2811 NR 9 TC 15 Z9 15 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD JUL PY 1994 VL 170 IS 1 BP 216 EP 219 PG 4 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA NR965 UT WOS:A1994NR96500033 PM 8014503 ER PT J AU KAIN, KC GOPINATH, R YAU, Y TEMAHIVONG, T WONGSRICHANALAI, C AF KAIN, KC GOPINATH, R YAU, Y TEMAHIVONG, T WONGSRICHANALAI, C TI IN-VIVO RESPONSE OF FALCIPARUM-MALARIA TO CHLOROQUINE IN SOUTHERN THAILAND SO JOURNAL OF INFECTIOUS DISEASES LA English DT Letter ID POLYMERASE CHAIN-REACTION; PLASMODIUM-FALCIPARUM C1 UNIV TORONTO,TORONTO,ON,CANADA. THAI MINIST PUBL HLTH,MALARIA REG OFF 4,BANGKOK,THAILAND. ARMED FORCES RES INST MED SCI,DEPT IMMUNOL,BANGKOK 10400,THAILAND. RP KAIN, KC (reprint author), TORONTO HOSP,DEPT MED,TROP DIS UNIT,ROOM EN G224,200 ELIZABETH ST,TORONTO M5G 2C4,ON,CANADA. NR 6 TC 3 Z9 3 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD JUL PY 1994 VL 170 IS 1 BP 258 EP 259 PG 2 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA NR965 UT WOS:A1994NR96500050 PM 8014517 ER PT J AU MARX, KA LIM, JO MINEHAN, D KAMATH, M TRIPATHY, SK KAPLAN, DL AF MARX, KA LIM, JO MINEHAN, D KAMATH, M TRIPATHY, SK KAPLAN, DL TI INTELLIGENT MATERIALS PROPERTIES OF DNA AND STRATEGIES FOR ITS INCORPORATION INTO ELECTROACTIVE POLYMERIC THIN-FILM SYSTEMS SO JOURNAL OF INTELLIGENT MATERIAL SYSTEMS AND STRUCTURES LA English DT Article ID LANGMUIR-BLODGETT-FILMS; STREPTAVIDIN AB We propose to create a novel class of intelligent materials by integrating two separate classes of intelligent materials-one biological and the other a thin film conducting polymer. The first class, DNA possesses superior intelligent material properties designed over evolutionary time to function specifically and efficiently in integrated macromolecular arrays in cells called chromosomes. The second material is the polymeric thin film or two-dimensional Langmuir Blodgett (LB) monolayer film. In our approach, films will be comprised of electroactive alkylated conducting polymeric materials, such as polyalkylpyrrole and polyalkylthiophene, that are derivatized with biotin. Steptavidin conjugated DNA will be attached directly or biotinylated DNA will be stably attached to this film via a bridging streptavidin protein. To date, the bulk of our work has centered on characterizing the DNA binding to thick films of conducting polymers. A near term aim is to incorporate this signal transduction system into fiber optic biosensors for specifically detecting nucleic acid analyte. Our ultimate aim is to create novel ordered structures possessing unique integrated intelligent functions which respond to their environment and provide signal transduction approaches via their electronic and optical functions. C1 USA,DIV BIOTECHNOL,NATICK,MA 01760. UNIV MASSACHUSETTS,CTR ADV MAT,LOWELL,MA 01854. RP MARX, KA (reprint author), UNIV MASSACHUSETTS,DEPT CHEM,LOWELL,MA 01854, USA. NR 20 TC 9 Z9 9 U1 0 U2 1 PU TECHNOMIC PUBL CO INC PI LANCASTER PA 851 NEW HOLLAND AVE, BOX 3535, LANCASTER, PA 17604 SN 1045-389X J9 J INTEL MAT SYST STR JI J. Intell. Mater. Syst. Struct. PD JUL PY 1994 VL 5 IS 4 BP 447 EP 454 DI 10.1177/1045389X9400500401 PG 8 WC Materials Science, Multidisciplinary SC Materials Science GA PA681 UT WOS:A1994PA68100001 ER PT J AU CITES, JS ASHLEY, PR AF CITES, JS ASHLEY, PR TI HIGH-PERFORMANCE MACH-ZEHNDER MODULATORS IN MULTIPLE-QUANTUM-WELL GAAS/ALGAAS SO JOURNAL OF LIGHTWAVE TECHNOLOGY LA English DT Article ID WAVE-GUIDES; INTENSITY MODULATORS; GAAS; ABSORPTION AB We demonstrate Mach-Zehnder interferometric waveguide intensity modulators which employ electrorefraction due to the quantum-confined Stark effect in multiple quantum well (MQW) GaAs/AlGaAs. These devices exhibit average haff-wave voltage-length products as low as 3.0 V . mm and extinction ratios greater than 23.8 dB, which are superior to any MQW devices of this type. An effective index based model is developed to extract linear and quadratic electro-optic coefficients from the modulation data. Also, the power handling limitations of MQW modulators are discussed in terms of device performance and catastrophic electrical failure. C1 USA,MISSILE COMMAND,CTR RES DEV & ENGN,AMSMI RD WS CM,REDSTONE ARSENAL,AL 35898. NR 19 TC 4 Z9 4 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0733-8724 J9 J LIGHTWAVE TECHNOL JI J. Lightwave Technol. PD JUL PY 1994 VL 12 IS 7 BP 1167 EP 1173 DI 10.1109/50.301809 PG 7 WC Engineering, Electrical & Electronic; Optics; Telecommunications SC Engineering; Optics; Telecommunications GA PA263 UT WOS:A1994PA26300009 ER PT J AU MCKENNEY, JE AF MCKENNEY, JE TI ON ARTILLERY - GUDMUNDSSON,BI SO JOURNAL OF MILITARY HISTORY LA English DT Book Review RP MCKENNEY, JE (reprint author), USA, CTR MIL HIST, WASHINGTON, DC 20310 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 USA SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD JUL PY 1994 VL 58 IS 3 BP 521 EP 523 PG 3 WC History SC History GA NU791 UT WOS:A1994NU79100011 ER PT J AU GILL, JH AF GILL, JH TI ON THE NAPOLEONIC WARS - CHANDLER,DG SO JOURNAL OF MILITARY HISTORY LA English DT Book Review RP GILL, JH (reprint author), USA,WASHINGTON,DC 20310, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU VIRGINIA MILITARY INST PI LEXINGTON PA LEXINGTON, VA 24450 SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD JUL PY 1994 VL 58 IS 3 BP 525 EP 527 DI 10.2307/2944145 PG 3 WC History SC History GA NU791 UT WOS:A1994NU79100015 ER PT J AU RAUGH, HE AF RAUGH, HE TI HELLS FOUNDATIONS - A SOCIAL-HISTORY OF THE TOWN OF BURY IN THE AFTERMATH OF THE GALLIPOLI CAMPAIGN - MOORHOUSE,G SO JOURNAL OF MILITARY HISTORY LA English DT Book Review RP RAUGH, HE (reprint author), USA,WASHINGTON,DC 20310, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU VIRGINIA MILITARY INST PI LEXINGTON PA LEXINGTON, VA 24450 SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD JUL PY 1994 VL 58 IS 3 BP 535 EP 536 DI 10.2307/2944152 PG 2 WC History SC History GA NU791 UT WOS:A1994NU79100022 ER PT J AU MANGANARO, AM HAMMOND, HL WILLIAMS, TP AF MANGANARO, AM HAMMOND, HL WILLIAMS, TP TI INTRAOSSEOUS ANGIOLIPOMA OF THE MANDIBLE - A CASE-REPORT AND REVIEW OF THE LITERATURE SO JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY LA English DT Review C1 BROOKE ARMY MED CTR,DEPT ORAL & MAXILLOFACIAL SURG & ANAT PATHOL,FT SAM HOUSTON,TX 78234. USA,FT SAM HOUSTON,TX 78234. UNIV IOWA,COLL DENT,IOWA CITY,IA 52242. NR 6 TC 14 Z9 15 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0278-2391 J9 J ORAL MAXIL SURG JI J. Oral Maxillofac. Surg. PD JUL PY 1994 VL 52 IS 7 BP 767 EP 769 DI 10.1016/0278-2391(94)90498-7 PG 3 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA NU820 UT WOS:A1994NU82000026 PM 8006745 ER PT J AU MADIGAN, WP WERTZ, D COCKERHAM, GC THACH, AB AF MADIGAN, WP WERTZ, D COCKERHAM, GC THACH, AB TI RETINAL-DETACHMENT IN OSTEOGENESIS IMPERFECTA SO JOURNAL OF PEDIATRIC OPHTHALMOLOGY & STRABISMUS LA English DT Note RP MADIGAN, WP (reprint author), WALTER REED ARMY MED CTR,OPHTHALMOL SERV,WASHINGTON,DC 20307, USA. NR 0 TC 15 Z9 16 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 SN 0191-3913 J9 J PEDIATR OPHTHALMOL JI J. Pediatr. Ophthalmol. Strabismus. PD JUL-AUG PY 1994 VL 31 IS 4 BP 268 EP 269 PG 2 WC Ophthalmology; Pediatrics SC Ophthalmology; Pediatrics GA PH811 UT WOS:A1994PH81100016 PM 7807308 ER PT J AU SHAFRIR, Y AF SHAFRIR, Y TI BENIGN FAMILIAL INFANTILE EPILEPSY SO JOURNAL OF PEDIATRICS LA English DT Letter C1 UNIFORMED SERV UNIV HLTH SCI, F EDWARD HEBERT SCH MED, BETHESDA, MD 20814 USA. RP SHAFRIR, Y (reprint author), WALTER REED ARMY MED CTR, CHILD & ADOLESCENT NEUROL SERV, WASHINGTON, DC 20307 USA. NR 3 TC 1 Z9 1 U1 0 U2 2 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0022-3476 EI 1097-6833 J9 J PEDIATR-US JI J. Pediatr. PD JUL PY 1994 VL 125 IS 1 BP 174 EP 175 DI 10.1016/S0022-3476(94)70163-6 PG 2 WC Pediatrics SC Pediatrics GA NW317 UT WOS:A1994NW31700045 PM 8021777 ER PT J AU LEGGETT, DC AF LEGGETT, DC TI SOLVATOCHROMIC LINEAR SOLVATION ENERGY RELATIONSHIP IN DESCRIBING DRUG SOLUBILITIES - COMMENTS SO JOURNAL OF PHARMACEUTICAL SCIENCES LA English DT Note RP LEGGETT, DC (reprint author), USA,COLD REG RES & ENGN LAB,GEOCHEM SCI BRANCH,72 LYME RD,HANOVER,NH 03755, USA. NR 2 TC 3 Z9 3 U1 0 U2 1 PU AMER PHARMACEUTICAL ASSN PI WASHINGTON PA 2215 CONSTITUTION AVE NW, WASHINGTON, DC 20037 SN 0022-3549 J9 J PHARM SCI JI J. Pharm. Sci. PD JUL PY 1994 VL 83 IS 7 BP 1065 EP 1065 DI 10.1002/jps.2600830728 PG 1 WC Chemistry, Medicinal; Chemistry, Multidisciplinary; Pharmacology & Pharmacy SC Pharmacology & Pharmacy; Chemistry GA NX390 UT WOS:A1994NX39000027 PM 7965667 ER PT J AU TANG, TL KIANG, JG COX, BM AF TANG, TL KIANG, JG COX, BM TI OPIOIDS ACTING THROUGH DELTA-RECEPTORS ELICIT A TRANSIENT INCREASE IN THE INTRACELLULAR FREE CALCIUM-CONCENTRATION IN DORSAL-ROOT GANGLION-NEUROBLASTOMA HYBRID ND8-47 CELLS SO JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS LA English DT Article ID ACTION-POTENTIAL DURATION; SENSORY NEURONS; NG108-15 CELLS; SUBSTANCE-P; SPINAL-CORD; RELEASE; ACTIVATION; AGONISTS; MORPHINE; BINDING AB The neuronal cell line ND8-47 (neuroblastoma x dorsal root ganglion neuron hybrid) expressed opioid delta-type receptors. We report opioid-induced changes in cytosolic intracellular free calcium ([Ca++](i)) in differentiated ND8-47 cells. Delta-opioid receptor agonists induced a transient (<2 min) increase in [Ca++](i) in a concentration-dependent fashion with the potency order: [D-Ser(2),Leu(5)]enkephalin-Thr (DSLET) greater than or equal to deltorphin II > [D-Pen(2,5)] enkephalin. Their effects were blocked by naloxone (IC50 = 20 nM) and naltrindole (IC50 = 2.5 nM). Selective mu and kappa receptor agonists had no effect on [Ca++](i). The subtype specific delta receptor antagonists, 7-benzylidene naltrexone (delta-1) and naltriben (delta(-2)), were used to characterize further the subtype of delta receptors mediated by this response. Naltriben was more potent than 7-benzylidene naltrexone in antagonizing the DSLET-induced increase in [Ca++](i). The increase in [Ca++](i) induced by DSLET was blocked by nifedipine (1 mu M) or verapamil (1 mu M), and was not observed in the absence of external calcium. Changes in [Ca++](i) also were measured in single ND8-47 cells. The percentage of cells responding to DSLET (1 mu M), deltorphin-II (1 mu M) and [D-Pen(2,5)]enkephalin (1 mu M) were 86, 84 and 37%, respectively. The results suggest that an increase in [Ca++](i) induced by opioids is mediated through opioid delta receptors which can activate dihydropyridine-sensitive Ca++ channels. C1 UNIFORMED SERV UNIV HLTH SCI,DEPT PHARMACOL,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,DEPT CLIN PHYSIOL,DIV MED,WASHINGTON,DC 20307. FU NIDA NIH HHS [DA03102] NR 30 TC 44 Z9 46 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-3565 J9 J PHARMACOL EXP THER JI J. Pharmacol. Exp. Ther. PD JUL PY 1994 VL 270 IS 1 BP 40 EP 46 PG 7 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA PC025 UT WOS:A1994PC02500007 PM 8035339 ER PT J AU EDGE, HL AF EDGE, HL TI COMPUTATION OF THE ROLL MOMENT FOR A PROJECTILE WITH WRAP-AROUND FINS SO JOURNAL OF SPACECRAFT AND ROCKETS LA English DT Article AB Flowfield solutions of a projectile with wrap-around fins have been computed for velocities ranging from Mach 1.3 to Mach 3.0. The flowfield solutions were computed with a time-marching, three-dimensional, zonal, full Navier-Stokes code. The roll moment coefficient was computed from the flowfield solutions and compared to the roll moment coefficient obtained experimentally for a similar wrap-around fin projectile. The roll moment coefficient computations show favorable agreement with experimental measurements in predicting changes of the roll moment coefficient magnitude and sign as a function of the flight Mach number. This demonstrates computational fluid dynamics' capability as a promising method for reliably predicting the roll moment coefficient of projectiles with wrap-around fins. RP EDGE, HL (reprint author), USA,RES LAB,ABERDEEN PROVING GROUND,MD 21005, USA. NR 10 TC 10 Z9 10 U1 0 U2 2 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091 SN 0022-4650 J9 J SPACECRAFT ROCKETS JI J. Spacecr. Rockets PD JUL-AUG PY 1994 VL 31 IS 4 BP 615 EP 620 DI 10.2514/3.26486 PG 6 WC Engineering, Aerospace SC Engineering GA PF146 UT WOS:A1994PF14600012 ER PT J AU NORTON, SA RUZE, P AF NORTON, SA RUZE, P TI KAVA DERMOPATHY SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Article AB Kava is a psychoactive beverage used ceremonially for thousands of years by Pacific Islanders. Kava is made from the root of the pepper plant, Piper methysticum, found in Polynesia, Melanesia, and Micronesia. The beverage is a nonfermented depressant with complex neuropharmacologic properties that causes a tranquil state of intoxication. Kava also affects the skin, causing a peculiar scaly eruption. The cutaneous effects were first reported by members of Captain James Cook's Pacific expeditions, but they have never been described in dermatologic literature. Heavy kava drinkers acquire a reversible ichthyosiform eruption, kava dermopathy. The cause is unknown but may relate to interference with cholesterol metabolism. Today kava is used across the Pacific in both traditional ceremonies and informal social events. In Western nations, kava is sold as a relaxant by health food stores. This article explores the history of kava dermopathy from Cook's early reports to its presence today. C1 UNIV NEW MEXICO,SCH MED,DEPT MED,ALBUQUERQUE,NM 87131. RP NORTON, SA (reprint author), TRIPLER ARMY MED CTR,DEPT MED,DERMATOL SERV,HONOLULU,HI 96859, USA. NR 48 TC 72 Z9 73 U1 0 U2 6 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD JUL PY 1994 VL 31 IS 1 BP 89 EP 97 PG 9 WC Dermatology SC Dermatology GA NU956 UT WOS:A1994NU95600016 PM 8021378 ER PT J AU BLANKEN, CL PAUSDER, HJ AF BLANKEN, CL PAUSDER, HJ TI INVESTIGATION OF THE EFFECTS OF BANDWIDTH AND TIME-DELAY ON HELICOPTER ROLL-AXIS HANDLING QUALITIES SO JOURNAL OF THE AMERICAN HELICOPTER SOCIETY LA English DT Article AB Several years of cooperative research conducted under the U.S./German Memorandum of Understanding (MOU) in helicopter aeromechanics have recently resulted in a successful handling qualities study. The focus of this cooperative research has been the effect of time delays in a high bandwidth vehicle on handling qualities. The jointly performed study included the use of U.S. ground-based simulation and German in-flight simulation facilities. The NASA-Ames Vertical Motion Simulator (VMS) was used to develop a high bandwidth slalom tracking task which took into consideration the constraints of the facilities, The VMS was also used to define a range of tbe test parameters and to perform initial handling qualities evaluations, The flight tests were conducted using DLR's variable-stability BO 105 S3 Advanced Technology Testing Helicopter System (ATTHeS). Configurations included a rate command and an attitude command response system with added time delays of up to 100 milliseconds over the baseline and band width values between 1.5 and 4.5 rad/sec. Sixty-six evaluations were performed in about 25 hours of flight time during ten days of testing. The results indicate a need to more tightly constrain the allowable rob aa;is phase delay for the Level 1 and Level 2 requirements in the U.S. Army's specification for helicopter handling qualities, ADS-33C. C1 DEUTSCH FORSCH ANSTALT LUFT & RAUMFAHRT EV,INST FLUGMECH,BRAUNSCHWEIG,GERMANY. RP BLANKEN, CL (reprint author), USA,AVIAT & TROOP COMMAND,AMES RES CTR,MOFFETT FIELD,CA, USA. NR 23 TC 4 Z9 4 U1 0 U2 0 PU AMER HELICOPTER SOC INC PI ALEXANDRIA PA 217 N WASHINGTON ST, ALEXANDRIA, VA 22314 SN 0002-8711 J9 J AM HELICOPTER SOC JI J. Am. Helicopter Soc. PD JUL PY 1994 VL 39 IS 3 BP 24 EP 33 PG 10 WC Engineering, Aerospace SC Engineering GA RN422 UT WOS:A1994RN42200003 ER PT J AU MOAS, E BOITNOTT, RL GRIFFIN, OH AF MOAS, E BOITNOTT, RL GRIFFIN, OH TI AN ANALYTICAL AND EXPERIMENTAL INVESTIGATION OF THE RESPONSE OF THE CURVED, COMPOSITE FRAME SKIN SPECIMENS SO JOURNAL OF THE AMERICAN HELICOPTER SOCIETY LA English DT Article AB Six-foot diameter, semicircular graphite/epoxy specimens representative of generic aircraft frames were loaded quasistatically to determine their load response and failure mechanisms for large deflections that occur in airplane crashes, These frame/skin specimens consisted of a cylindrical skin section co-cured with a semicircular I-frame. The skin provided the necessary lateral stiffness to keep deformations in the plane of the frame in order to realistically represent deformations as they occur in actual fuselage structures, Various frame laminate stacking sequences and geometries were evaluated by statically loading the specimen until multiple failures occurred, Two analytical methods were compared for modeling the frame/skin specimens: a two-dimensional shed finite element analysis and a one-dimensional, closed-form, curved beam solution derived using an energy method, Flange effectivities were included in the beam analysis to account for the curling phenomenon that occurs in thin flanges of curved beams. Good correlation was obtained between experimental results and the analytical predictions of the linear response of the frames prior to the initial failure, The specimens were found to be useful for evaluating composite frame designs, C1 LANGLEY RES CTR,USA,RES LAB,VEHICLE STRUCT DIRECTORATE,HAMPTON,VA. VIRGINIA POLYTECH INST & STATE UNIV,COLL ENGN,BLACKSBURG,VA 24061. RP MOAS, E (reprint author), ANALYT SERV & MAT INC,HAMPTON,VA 23666, USA. NR 14 TC 1 Z9 1 U1 0 U2 0 PU AMER HELICOPTER SOC INC PI ALEXANDRIA PA 217 N WASHINGTON ST, ALEXANDRIA, VA 22314 SN 0002-8711 J9 J AM HELICOPTER SOC JI J. Am. Helicopter Soc. PD JUL PY 1994 VL 39 IS 3 BP 58 EP 66 PG 9 WC Engineering, Aerospace SC Engineering GA RN422 UT WOS:A1994RN42200007 ER PT J AU CUNNIFF, JB VOUROS, P KAPLAN, DL FOSSEY, SA AF CUNNIFF, JB VOUROS, P KAPLAN, DL FOSSEY, SA TI EVIDENCE FOR THE DIRECT DESORPTION OF CROWN-ETHER METAL-ION COMPLEXES IN LIQUID SECONDARY IONIZATION MASS-SPECTROMETRY SO JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY LA English DT Article ID FAST-ATOM-BOMBARDMENT; GAS-PHASE; CATIONS AB The liquid secondary ionization mass spectra of crown ether solutions and crown ether solutions containing alkali metal cations were generated. Cesium cations acted as both the primary ion beam and as a competing gas-selvedge-phase reactant. The data suggest that crown ether complexes formed in the condensed phase survive intact the fast ion bombarding event and the transition into the gas phase. The data further suggest that crown ether complexes formed in the condensed phase predominate in the ion spectrum over the corresponding complexes formed in the selvedge. C1 NORTHEASTERN UNIV,DEPT CHEM,101 HURTIG HALL,BOSTON,MA 02115. NORTHEASTERN UNIV,BARNETT INST,BOSTON,MA 02115. USA,NATICK RES DEV & ENGN CTR,BIOTECHNOL BRANCH,NATICK,MA 01760. NR 35 TC 7 Z9 8 U1 1 U2 3 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 1044-0305 J9 J AM SOC MASS SPECTR JI J. Am. Soc. Mass Spectrom. PD JUL PY 1994 VL 5 IS 7 BP 638 EP 648 DI 10.1016/1044-0305(94)85005-4 PG 11 WC Chemistry, Analytical; Chemistry, Physical; Spectroscopy SC Chemistry; Spectroscopy GA NX169 UT WOS:A1994NX16900005 PM 24221966 ER PT J AU FAMINI, GR WILSON, LY AF FAMINI, GR WILSON, LY TI USING THEORETICAL DESCRIPTORS IN QUANTITATIVE STRUCTURE-PROPERTY RELATIONSHIPS - 3-CARBOXYBENZISOXAZOLE DECARBOXYLATION KINETICS SO JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2 LA English DT Article ID SOLVATION ENERGY RELATIONSHIPS; PHYSICAL ORGANIC-CHEMISTRY; DIPOLAR APROTIC-SOLVENTS; SINGLE IONS; MOLECULES; BENZISOXAZOLES; EQUILIBRIA; PARAMETERS; MECHANISM; RULES AB The decarboxylation rate of 3-carboxybenzisoxazoles depends on the substituent and strongly on the solvent. Solvent dependence explanation has been based on solvent donor hydrogen bond acidity, ion pairing and dispersive interactions. Recently, to help sort the solvent effects, the empirical, Kamlet-Taft-Abraham solvatochromic parameter set has been used as a probe in a multilinear correlation analysis based on the linear solvation energy relationship (LSER) model. This paper extends the LSER work with a theoretical, computational set of molecular parameters to analyse the rate data. Good correlations and physical interpretations result and agree with empirical observations and LSER correlations. These imply a rate decrease with solvent donor hydrogen bond acidity (HBA) and increase with acceptor hydrogen bond basicity (HBB). Mechanistic interpretation can involve the way charge delocalization on the carboxylate is effected by solvent HBA interaction and by ion pairing which is, in turn, effected by solvent HBB. C1 USA,EDGEWOOD RES DEV & ENGN CTR,ABERDEEN PROVING GROUND,MD 21010. LA SIERRA UNIV,DEPT CHEM,RIVERSIDE,CA 92515. NR 46 TC 23 Z9 23 U1 1 U2 2 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK MILTON ROAD, CAMBRIDGE, CAMBS, ENGLAND CB4 4WF SN 0300-9580 J9 J CHEM SOC PERK T 2 JI J. Chem. Soc.-Perkin Trans. 2 PD JUL PY 1994 IS 7 BP 1641 EP 1650 DI 10.1039/p29940001641 PG 10 WC Chemistry, Organic; Chemistry, Physical SC Chemistry GA NW962 UT WOS:A1994NW96200042 ER PT J AU CHU, D GILMAN, S AF CHU, D GILMAN, S TI THE INFLUENCE OF METHANOL ON O(2) ELECTROREDUCTION AT A ROTATING PT DISK ELECTRODE IN ACID ELECTROLYTE SO JOURNAL OF THE ELECTROCHEMICAL SOCIETY LA English DT Article ID RUTHENIUM AD-ATOMS; OXYGEN REDUCTION; PHOSPHORIC-ACID; FUEL-CELLS; PLATINUM; OXIDATION; ELECTROCATALYSIS; ENHANCEMENT; CATALYSTS AB Using a rotating Pt electrode, the simultaneous electro-oxidation of methanol and electroreduction or O2 was studied in O2 saturated 0.5M H2SO4 solutions containing dissolved methanol. The two processes occurred with no apparent interaction above 0.8 V vs. a reversible H-2 electrode. At potentials below 0.8 V the net oxidation/reduction current is smaller (i.e., less cathodic) than would be expected if the reactions occurred with no interaction. The evidence suggests that the effect is due to partial poisoning of the O2 reduction process by adsorbed methanol. At sufficiently low potentials (approximately 0.4 V), O2 electroreduction reaches the same diffusion-limited whether or not methanol is added. The mechanism of O2 electroreduction appears to remain unchanged in the presence of methanol. RP CHU, D (reprint author), USA,RES LAB,ELECTR & POWER SOURCES DIRECTORATE,FT MONMOUTH,NJ 07703, USA. NR 29 TC 134 Z9 137 U1 1 U2 10 PU ELECTROCHEMICAL SOC INC PI PENNINGTON PA 10 SOUTH MAIN STREET, PENNINGTON, NJ 08534 SN 0013-4651 J9 J ELECTROCHEM SOC JI J. Electrochem. Soc. PD JUL PY 1994 VL 141 IS 7 BP 1770 EP 1773 DI 10.1149/1.2055002 PG 4 WC Electrochemistry; Materials Science, Coatings & Films SC Electrochemistry; Materials Science GA NX196 UT WOS:A1994NX19600018 ER PT J AU WOOD, GL NEURGAONKAR, RR AF WOOD, GL NEURGAONKAR, RR TI PHOTOREFRACTIVE AND OPTICAL-PROPERTIES OF CERIUM-DOPED (SRCA)2NANB5O15 SO JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICS LA English DT Article ID BARIUM-TITANATE; CRYSTALS; NIOBATE AB The photorefractive effect is demonstrated in a single crystal of ferroelectric Ba-modified Ce-doped (SrCa)2NaNb5O15, for the first time to our knowledge. From two-beam coupling the gain and the time response were found. The maximum intensity gain with ordinary light at a 488-nm wavelength was GAMMA - 10 cm-1, while the photorefractive time response was determined to be 1.85 s at an incident intensity of I = 1 W/cm2. The phase shift of the index gratings from the intensity grating was found to vary with angle from approximately 28-degrees at a 79-degrees crossing angle to 55-degrees at a 13-degrees crossing angle. The dark decay was measured, and the two-beam coupling intensity gain was found to oscillate with time. The oscillation period and the dc component were found to depend on the crossing angle. Beam fanning was observed with a transmitted beam reduction of 1.61 optical density and a time response of tau approximately 5.6 s at I = 230 mW/cm2. Finally, anisotropic conical diffraction was observed in the form of a partial ring pattern about the transmitted (extraordinary-polarized) incident beam in a direction opposite the beam fan. When the dependence of the angle between the ring and the transmitted beam is fitted to the change in the incident angle, it is possible to measure the birefringence, which was n(e) - n(o) = -0.051. C1 ROCKWELL SCI CTR,THOUSAND OAKS,CA 91360. RP WOOD, GL (reprint author), USA,RES LAB,FT BELVOIR,VA 22060, USA. NR 24 TC 3 Z9 3 U1 0 U2 0 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0740-3224 J9 J OPT SOC AM B JI J. Opt. Soc. Am. B-Opt. Phys. PD JUL PY 1994 VL 11 IS 7 BP 1211 EP 1220 DI 10.1364/JOSAB.11.001211 PG 10 WC Optics SC Optics GA NW109 UT WOS:A1994NW10900008 ER PT J AU MCLANE, GF BUCHWALD, WR CASAS, L COLE, MW AF MCLANE, GF BUCHWALD, WR CASAS, L COLE, MW TI MAGNETRON ENHANCED REACTIVE ION ETCHING OF GAAS IN CH4/H2/AR - SURFACE DAMAGE STUDY SO JOURNAL OF VACUUM SCIENCE & TECHNOLOGY A-VACUUM SURFACES AND FILMS LA English DT Article; Proceedings Paper CT 40th National Symposium of the American-Vacuum-Society CY NOV 15-19, 1993 CL ORLANDO, FL SP AMER VACUUM SOC ID ELECTRON-CYCLOTRON RESONANCE; HYDROGEN PLASMA; ALGAAS; PASSIVATION; C2H6/H2/AR; METHANE AB An investigation was performed of surface region etch-induced damage of GaAs magnetron reactive ion etched in CH4/H-2/Ar gas mixtures. Transmission electron microscope measurements revealed the presence of etch-induced defects which extended 4.3, 7.2, and 8.7 nm below the surface for Ar concentrations of 0%, 10%, and 20%, respectively, in the gas mixture. Auger electron spectroscopy measurements showed that etching produced an As-deficient surface region extending approximately 10 nm below the surface. The amount of As deficiency increased with Ar concentration, but was relatively unaffected by postetch annealing at 400-degrees-C for 30 s. Changes in Schottky barrier surface potential PHI(b) upon etching and subsequent annealing can be explained by a combination of H passivation effects and As removal from the surface, whereas changes in Schottky barrier diode ideality factor n can be explained by the presence of etch-induced surface region defects such as donorlike As vacancies and deep level recombination centers, both of which are passivated by H. RP MCLANE, GF (reprint author), USA,FT MONMOUTH,NJ 07703, USA. RI Schaff, William/B-5839-2009 NR 18 TC 3 Z9 3 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0734-2101 J9 J VAC SCI TECHNOL A JI J. Vac. Sci. Technol. A-Vac. Surf. Films PD JUL-AUG PY 1994 VL 12 IS 4 BP 1356 EP 1359 DI 10.1116/1.579321 PN 1 PG 4 WC Materials Science, Coatings & Films; Physics, Applied SC Materials Science; Physics GA NZ030 UT WOS:A1994NZ03000077 ER PT J AU COLE, MW HAN, WY CASAS, LM ECKART, DW JONES, KA AF COLE, MW HAN, WY CASAS, LM ECKART, DW JONES, KA TI PT/TI/GE/PD OHMIC CONTACTS TO GAAS - A STRUCTURAL, CHEMICAL, AND ELECTRICAL INVESTIGATION SO JOURNAL OF VACUUM SCIENCE & TECHNOLOGY A-VACUUM SURFACES AND FILMS LA English DT Article ID N-GAAS; GE; RESISTIVITY; MORPHOLOGY; DEPENDENCE; SYSTEMS AB Interface morphology, phase composition, and elemental diffusion of Pt/Ti/Ge/Pd ohmic contacts to both n+- and p+-GaAs have been investigated as a function of annealing temperature. Structural and chemical results were correlated with specific contact resistances (rho(c)) measured for each thermal treatment in an attempt to determine how the indiffusion of contact metal and the out-diffusion of Ga and As affect specific contact resistance, and how effective Ti is as a diffusion barrier. Annealing at 450-degrees-C yielded the lowest rho(c), approximately 6.4 X 10(-7) OMEGA CM2 . The interface was observed to be smooth and abrupt, and there was little As out-diffusion and Pt indiffusion. Two interface phases were detected; a primary phase, PdGe, and a secondary, Ga rich Pd-Ga-As ternary phase. The presence of this ternary phase is believed to be critical to contact formation on n-type GaAs. The Ti and Pt layers remained pristine. Annealing at 550-degrees-C resulted in a slightly higher p(c), approximately 2.1 X 10(-6) OMEGA Cm2. There was significant elemental diffusion within the contact metal and minor diffusion into the GaAs substrate. The interface possessed limited areas of spiking with uniform composition. Annealing at 600-degrees-C proved to have a detrimental effect on the rho(c), approximately 10(-4) OMEGA CM2. This electrical degradation was accompanied by strong chemical intermixing between the contact and substrate, resulting in a continuous nonplanar interface with deep multiphase protrusions, and the Ti layer no longer was effective as a diffusion barrier. C1 GEOCENTERS INC,LAKE HOPATCONG,NJ 07849. RP COLE, MW (reprint author), USA,RES LAB,FT MONMOUTH,NJ 07703, USA. NR 13 TC 32 Z9 32 U1 1 U2 6 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0734-2101 J9 J VAC SCI TECHNOL A JI J. Vac. Sci. Technol. A-Vac. Surf. Films PD JUL-AUG PY 1994 VL 12 IS 4 BP 1904 EP 1909 DI 10.1116/1.578980 PN 2 PG 6 WC Materials Science, Coatings & Films; Physics, Applied SC Materials Science; Physics GA NZ032 UT WOS:A1994NZ03200021 ER PT J AU YOUNG, VY SCHOENFELD, DW WEAVER, JF HOFLUND, GB HOKE, S AF YOUNG, VY SCHOENFELD, DW WEAVER, JF HOFLUND, GB HOKE, S TI EFFECTS OF CORROSION AND RECOVERY PROCESSES ON CHLORIDE-ION-SELECTIVE ELECTRODE SURFACES SO JOURNAL OF VACUUM SCIENCE & TECHNOLOGY A-VACUUM SURFACES AND FILMS LA English DT Article ID SILVER AB X-ray photoelectron spectroscopy (XPS), Auger electron spectroscopy (AES), ion scattering spectroscopy (ISS) and secondary-ion-mass spectrometry (SIMS) have been used to examine the composition of the visible corrosion layer formed on a chloride-ion-selective electrode (ISE) during exposure to a simulant solution containing dissolved Halon fire suppression by-products such as HBr. ISS depth profiling indicates that the Cl- is replaced by Br- forming a corrosion layer about 75 A thick. Surface recovery of the ISE by aqueous hydrochloric acid etching has also been studied as a function of acid concentration and etchant contact time. Based on XPS data, the optimum etching parameters have been found to be 0.5 mol L-1 aqueous HCI and a contact time of 290 s. XPS, AES, ISS, and SIMS data indicate that the HCI etch removes most of the Br- in the near-surface region, thus providing an in situ means of regenerating chloride-ion-selective electrodes. C1 UNIV FLORIDA,DIV CHEM ENGN,GAINESVILLE,FL 32611. USA,RES & DEV LAB,FREDERICK,MD 21702. RP YOUNG, VY (reprint author), UNIV FLORIDA,DEPT CHEM,GAINESVILLE,FL 32611, USA. NR 9 TC 0 Z9 0 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0734-2101 J9 J VAC SCI TECHNOL A JI J. Vac. Sci. Technol. A-Vac. Surf. Films PD JUL-AUG PY 1994 VL 12 IS 4 BP 2398 EP 2401 DI 10.1116/1.579221 PN 2 PG 4 WC Materials Science, Coatings & Films; Physics, Applied SC Materials Science; Physics GA NZ032 UT WOS:A1994NZ03200111 ER PT J AU MCLANE, GF CASAS, L REID, JS KOLAWA, E NICOLET, MA AF MCLANE, GF CASAS, L REID, JS KOLAWA, E NICOLET, MA TI REACTIVE ION ETCHING OF TA-SI-N DIFFUSION-BARRIERS IN CF4+O2 SO JOURNAL OF VACUUM SCIENCE & TECHNOLOGY B LA English DT Article ID GAAS; METALLIZATIONS; TANTALUM; PLASMA; ALGAAS; DEPENDENCE; RATES AB Ta36Si14N50 amorphous layers were reactive ion etched in CF4+O2 plasmas, The etch depth was determined as a function of gas composition, pressure, and cathode power. Adding small amounts of O2 to CF4 increased the etch rates up to approximately 15% O2 concentration, with etch rates then decreasing with further addition of O2. Etch rates increased with both pressure and power. Etching proceeded only after an initial delay time which depended upon gas composition and power. The delay is probably caused by a surface native oxide which must be removed before etching can commence. The presence of a surface oxide was observed from Auger electron spectroscopy intensity depth profile measurements and is estimated to be 2 nm thick. Under optimal conditions, the etch rate of Ta36Si14N50 is about seven times higher than for SiO2, thus providing a high degree of selectivity for integrated circuit processing. C1 CALTECH,PASADENA,CA 91125. RP MCLANE, GF (reprint author), USA,RES LAB,FT MONMOUTH,NJ 07703, USA. NR 19 TC 5 Z9 5 U1 0 U2 1 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 1071-1023 J9 J VAC SCI TECHNOL B JI J. Vac. Sci. Technol. B PD JUL-AUG PY 1994 VL 12 IS 4 BP 2352 EP 2355 DI 10.1116/1.587763 PG 4 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Physics, Applied SC Engineering; Science & Technology - Other Topics; Physics GA PD161 UT WOS:A1994PD16100011 ER PT J AU GELBARD, HA NOTTET, HSLM SWINDELLS, S JETT, M DZENKO, KA GENIS, P WHITE, R WANG, L CHOI, YB ZHANG, DX LIPTON, SA TOURTELLOTTE, WW EPSTEIN, LG GENDELMAN, HE AF GELBARD, HA NOTTET, HSLM SWINDELLS, S JETT, M DZENKO, KA GENIS, P WHITE, R WANG, L CHOI, YB ZHANG, DX LIPTON, SA TOURTELLOTTE, WW EPSTEIN, LG GENDELMAN, HE TI PLATELET-ACTIVATING-FACTOR - A CANDIDATE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE 1-INDUCED NEUROTOXIN SO JOURNAL OF VIROLOGY LA English DT Article ID RECEPTOR-MEDIATED NEUROTOXICITY; SIGNAL TRANSDUCTION MECHANISMS; TUMOR-NECROSIS-FACTOR; ARACHIDONIC-ACID; INFECTED MACROPHAGES; HIPPOCAMPAL-NEURONS; NMDA RESPONSES; NERVOUS-SYSTEM; FRONTAL-CORTEX; GANGLION-CELLS AB The pathogenesis of central nervous system disease during human immunodeficiency virus type 1 (HIV-1) infection revolves around productive viral infection of brain macrophages and microglia. Neuronal losses in the cortex and subcortical gray matter accompany macrophage infection. The question of how viral infection of brain macrophages ultimately leads to central nervous system (CNS) pathology remains unanswered. Our previous work demonstrated high-level production of tumor necrosis factor alpha, interleukin 1 beta, arachidonic acid metabolites, and platelet-activating factor (PAF) from HIV-infected monocytes and astroglia (H. E. Gendelman, P. Genis, M. Jett, and H. S. L. M. Nottet, in E. Major, ed., Technical Advances in AIDS Research in the Nervous System, in press; P. Genis, M. Jett, E. W. Bernton, H. A. Gelbard, K. Dzenko, R. Keane, L. Resnick, D. J. Volsky, L. G. Epstein, and H. E. Gendelmal, J. Exp. Med. 176:1703-1718, 1992). These factors, together, were neurotoxic. The relative role(s) of each of these candidate neurotoxins in HIV-1-related CNS dysfunction was not unraveled by these initial experiments. We now report that PAF is produced during HIV-1-infected monocyte-astroglia interactions. PAF was detected at high levels in CSF of HIV-1-infected patients with immunosuppression and signs of CNS dysfunction. The biologic significance of the results for neurological disease was determined by addition of PAF to cultures of primary human fetal cortical or rat postnatal retinal ganglion neurons. Here, PAF at concentrations of greater than or equal to 300 pg/ml produced neuronal death. The N-methyl-D-aspartate receptor antagonist MK-801 or memantine partially blocked the neurotoxic effects of PAF. The identification of PAF as an HIV-1-induced neurotoxin provides ne,v insights into how HIV-1 causes neurological impairment and how it may ultimately be ameliorated. C1 UNIV ROCHESTER,MED CTR,DEPT NEUROL,DIV CHILD NEUROL,ROCHESTER,NY 14642. UNIV ROCHESTER,MED CTR,DEPT PEDIAT,ROCHESTER,NY 14642. UNIV ROCHESTER,MED CTR,DEPT MICROBIOL & IMMUNOL,ROCHESTER,NY 14642. UNIV NEBRASKA,MED CTR,DEPT MED,VIRAL PATHOGENESIS LAB,OMAHA,NE 68198. UNIV NEBRASKA,MED CTR,DEPT PATHOL & MICROBIOL,OMAHA,NE 68198. UNIV NEBRASKA,MED CTR,EPPLEY INST RES CANC & ALLIED DIS,OMAHA,NE 68198. WALTER REED ARMY INST RES,DIV MOLEC PATHOL,WASHINGTON,DC. HARVARD UNIV,BRIGHAM & WOMENS HOSP,SCH MED,DEPT NEUROL,BOSTON,MA 02115. HARVARD UNIV,CHILDRENS BETH ISRAEL HOSP,SCH MED,DEPT NEUROL,BOSTON,MA 02115. HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,DEPT NEUROL,BOSTON,MA 02115. VET ADM MED CTR,WADSWORTH DIV,NATL NEUROL RES SPECIMEN BANK,LOS ANGELES,CA 90073. VET ADM MED CTR,BRENTWOOD DIV,NATL NEUROL RES SPECIMEN BANK,LOS ANGELES,CA 90073. FU NEI NIH HHS [R01 EY09024-03]; NHLBI NIH HHS [R01 HL043628]; NICHD NIH HHS [P01 HD29587-01]; NIDA NIH HHS [R01 DA017618]; NINDS NIH HHS [P01 NS031492, P01 NS31492-01] NR 62 TC 290 Z9 302 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0022-538X J9 J VIROL JI J. Virol. PD JUL PY 1994 VL 68 IS 7 BP 4628 EP 4635 PG 8 WC Virology SC Virology GA NQ763 UT WOS:A1994NQ76300057 PM 8207837 ER PT J AU BARTH, J AF BARTH, J TI SURVIVING THE COMING MUTUAL FUND CRISIS - HOW YOU CAN TAKE DEFENSIVE MEASURES TO PROTECT YOUR MONEY - CHRISTENSEN,D SO LIBRARY JOURNAL LA English DT Book Review RP BARTH, J (reprint author), US MIL ACAD LIB,W POINT,NY, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 SN 0363-0277 J9 LIBR J JI Libr. J. PD JUL PY 1994 VL 119 IS 12 BP 106 EP 106 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA NX417 UT WOS:A1994NX41700179 ER PT J AU MERKEL, KG BRIGHT, VM SCHAUER, SN BARRETTE, J AF MERKEL, KG BRIGHT, VM SCHAUER, SN BARRETTE, J TI THERMALLY STABLE WTIAU NONALLOYED OHMIC CONTACTS ON IN0.5GA0.5AS FOR GAAS-ALGAAS HETEROJUNCTION BIPOLAR-TRANSISTOR APPLICATIONS SO MATERIALS SCIENCE AND ENGINEERING B-SOLID STATE MATERIALS FOR ADVANCED TECHNOLOGY LA English DT Article AB This paper demonstrates WTiAu as a thermally stable, low resistance, non-alloyed, emitter ohmic contact for GaAs-AlGaAs heterojunction bipolar transistor applications. The minimum W layer thickness required for low contact resistance and long-term thermal stability was obtained. A W layer 900 angstrom thick yielded the lowest contact resistance (R(c) = 0.045 OMEGA mm) with a high degree of uniformity after (1) a collector ohmic contact rapid thermal annealing cycle at 420-degrees-C and (2) 500 h at 250-degrees-C. Secondary ion mass spectroscopy results indicate that In outdiffusion contributes to the thermal instability when thinner W layers are used. C1 USAF,INST TECHNOL,DEPT ELECT & COMP ENGN,WRIGHT PATTERSON AFB,OH 45433. USA,RES LAB,FT MONMOUTH,NJ 07703. WRIGHT LAB,WRIGHT PATTERSON AFB,OH 45433. NR 13 TC 5 Z9 5 U1 0 U2 0 PU ELSEVIER SCIENCE SA LAUSANNE PI LAUSANNE 1 PA PO BOX 564, 1001 LAUSANNE 1, SWITZERLAND SN 0921-5107 J9 MAT SCI ENG B-SOLID JI Mater. Sci. Eng. B-Solid State Mater. Adv. Technol. PD JUL PY 1994 VL 25 IS 2-3 BP 175 EP 178 DI 10.1016/0921-5107(94)90221-6 PG 4 WC Materials Science, Multidisciplinary; Physics, Condensed Matter SC Materials Science; Physics GA NX767 UT WOS:A1994NX76700012 ER PT J AU RUBIOPALIS, Y CURTIS, CF GONZALES, C WIRTZ, RA AF RUBIOPALIS, Y CURTIS, CF GONZALES, C WIRTZ, RA TI HOST CHOICE OF ANOPHELINE MOSQUITOS IN A MALARIA ENDEMIC AREA OF WESTERN VENEZUELA SO MEDICAL AND VETERINARY ENTOMOLOGY LA English DT Article DE ANOPHELES-NUNEZTOVARI; AN-OSWALDOI; AN-TRIANNULATUS; PLASMODIUM-VIVAX; BLOODMEAL; MALARIA; VENEZUELA ID IMMUNOSORBENT-ASSAY ELISA; FEEDING PATTERNS; BLOOD-MEALS; IDENTIFICATION; TRANSMISSION; BEHAVIOR AB Bloodmeals of exophilic anopheline mosquitoes collected resting on vegetation in a malaria endemic area in western Venezuela were identified by ELISA. Using a TMB peroxidase substrate in the ELISA, human bloodmeals were readily identified up to 40 h after ingestion in all laboratory-fed mosquitoes tested. Assay sensitivity declined to 75% identifiable 44 h post-feeding. The Human Blood Index and the Feeding Index of each species differed between the three villages studied. An.triannulatus was generally more anthropophilic than An.nuneztovari and An.oswaldoi. These contrasting results emphasize the difficulties of interpreting host choice data. C1 UNIV LONDON LONDON SCH HYG & TROP MED,DEPT MED PARASITOL,KEPPEL ST,LONDON WC1E 7HT,ENGLAND. ESCUELA MALARIOL & SANEAMIENTO AMBIENTAL,DIV INVEST,MARACAY,VENEZUELA. WALTER REED ARMY INST RES,DEPT ENTOMOL,DIV COMMUNICABLE DIS & IMMUNOL,WASHINGTON,DC 20307. NR 29 TC 18 Z9 19 U1 1 U2 2 PU BLACKWELL SCIENCE LTD PI OXFORD PA OSNEY MEAD, OXFORD, OXON, ENGLAND OX2 0EL SN 0269-283X J9 MED VET ENTOMOL JI Med. Vet. Entomol. PD JUL PY 1994 VL 8 IS 3 BP 275 EP 280 DI 10.1111/j.1365-2915.1994.tb00509.x PG 6 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA NV982 UT WOS:A1994NV98200010 PM 7949319 ER PT J AU CARLIN, K CARLIN, S AF CARLIN, K CARLIN, S TI COULD THE DEFECT IN TYPE-II DIABETES-MELLITUS BE THE ABSENCE OF A POSTPRANDIAL ALKALOSIS SO MEDICAL HYPOTHESES LA English DT Article ID INSULIN; BINDING; PH AB Perhaps the liver following a meal has a significant change in pH. Insulin binding and several enzymes important in the postprandial state for processing lipids, proteins and carbohydrates all appear to have alkaline optimal pH levels. Diabetes mellitus type II could be due to the liver failing to obtain the optimum pH for insulin binding. RP CARLIN, K (reprint author), USA,BROOKE ARMY MED CTR,DEPT ENDOCRINOL,SAN ANTONIO,TX 78234, USA. NR 14 TC 0 Z9 0 U1 0 U2 0 PU CHURCHILL LIVINGSTONE PI EDINBURGH PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE, LEITH WALK, EDINBURGH, MIDLOTHIAN, SCOTLAND EH1 3AF SN 0306-9877 J9 MED HYPOTHESES JI Med. Hypotheses PD JUL PY 1994 VL 43 IS 1 BP 19 EP 20 DI 10.1016/0306-9877(94)90044-2 PG 2 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA NY270 UT WOS:A1994NY27000005 PM 7968716 ER PT J AU CHISICK, MC AF CHISICK, MC TI SATISFACTION WITH MILITARY DENTAL-CARE BY ACTIVE-DUTY SOLDIERS SO MILITARY MEDICINE LA English DT Article AB In Fall 1992, a random, worldwide sample of 5,474 enlisted personnel and 4,036 officers was surveyed on satisfaction with 28 attributes of Army dental care using self-administered questionnaires. Simple descriptive statistics for each attribute were derived, as was a composite overall satisfaction score using factor analysis. Composite scores were regressed on demographics, dental utilization, and access barriers to identify those factors that have an impact on a soldier's overall satisfaction with Army dental care. Results show above average satisfaction with most attributes of Army dental care except access attributes. Dental utilization and age exerted a positive impact on overall satisfaction; access barriers and assignment to a combat unit had a negative impact. The impact of race was mixed. Age had the strongest impact on overall satisfaction. Results suggest that improving satisfaction with Army dental care must come from improving access. This can be attained only by increasing dental manpower and resources. RP CHISICK, MC (reprint author), USA,INST DENT RES,EPIDEMIOL SECT,FT GEORGE G MEADE,MD 20755, USA. NR 0 TC 3 Z9 3 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUL PY 1994 VL 159 IS 7 BP 501 EP 504 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA PL885 UT WOS:A1994PL88500009 PM 7816222 ER PT J AU PHILLIPS, WJ AF PHILLIPS, WJ TI STARVATION AND SURVIVAL - SOME MILITARY CONSIDERATIONS SO MILITARY MEDICINE LA English DT Article AB The combination of calorie deprivation and forced evasion is a unique and severe stress. The physiologic adaptations which occur under these conditions are complex. Performance decrements and psychological changes are evident within 24 hours of cessation of nutritional intake. Although marked losses of both lean tissue and total body mass are unavoidable, ultimate survival duration depends on many things. This article reviews some of the physiologic and pathologic changes which occur during total calorie deprivation and some of the factors which impact on the ability to survive. RP PHILLIPS, WJ (reprint author), USA,SPECIAL OPERAT COMMAND,528TH SUPPORT BATTALION SPECIAL OPERAT AIRBORNE,FT BRAGG,NC 28307, USA. NR 0 TC 5 Z9 5 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUL PY 1994 VL 159 IS 7 BP 513 EP 516 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA PL885 UT WOS:A1994PL88500011 PM 7816224 ER PT J AU BERIGAN, T WATT, TJ AF BERIGAN, T WATT, TJ TI DILANTIN TOXICITY PRESENTING AS MUTISM FOLLOWING SEVERE HEAD-INJURY - CASE-REPORT SO MILITARY MEDICINE LA English DT Note AB A case is presented in which a patient was placed on phenytoin following open depressed skull fracture. He subsequently was lost to follow-up, and then presented with several complaints, among them mutism, found to be related to phenytoin toxicity. There are no reports to date of this condition being caused by phenytoin. The issue is again raised of the risks versus benefits of long-term anticonvulsant prophylaxis following severe head injury. RP BERIGAN, T (reprint author), TRIPLER ARMY MED CTR,HSHKDSN,HONOLULU,HI 96859, USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUL PY 1994 VL 159 IS 7 BP 533 EP 534 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA PL885 UT WOS:A1994PL88500017 PM 7816230 ER PT J AU VAUGHAN, MK MENENDEZPELAEZ, A BUZZELL, GR VAUGHAN, GM LITTLE, JC REITER, RJ AF VAUGHAN, MK MENENDEZPELAEZ, A BUZZELL, GR VAUGHAN, GM LITTLE, JC REITER, RJ TI CIRCADIAN-RHYTHMS IN REPRODUCTIVE AND THYROID-HORMONES IN GONADALLY REGRESSED MALE HAMSTERS EXPOSED TO NATURAL AUTUMN PHOTOPERIOD AND TEMPERATURE CONDITIONS SO NEUROENDOCRINOLOGY LA English DT Article DE THYROXINE; TRIIODOTHYRONINE; THYROTROPIN (TRH); BROWN ADIPOSE TISSUE; CHOLESTEROL; LUTEINIZING HORMONE; FOLLICLE-STIMULATING HORMONE; PROLACTIN; TESTOSTERONE; 5'-DEIODINASE, TYPE-II; PHOTOPERIOD, SHORT; COLD EXPOSURE; THYROID HORMONES; GONADAL STEROIDS; ADIPOSE TISSUE; GONADOTROPINS; STRESS; TEMPERATURE; HAMSTER ID MALE SYRIAN-HAMSTERS; THYROXINE 5'-DEIODINASE ACTIVITY; MALE GOLDEN-HAMSTERS; PINEAL-GLAND; HOMOLOGOUS RADIOIMMUNOASSAY; TESTICULAR REGRESSION; SERUM GONADOTROPINS; LIGHT DEPRIVATION; PROLACTIN; MELATONIN AB Two groups of young adult male Syrian hamsters were kept in a vivarium at 22 degrees C and a light:dark cycle of 14.5:9.5 h (lights on 06.30 h; indoor) or in a naturally decreasing photoperiod and fluctuating ambient temperature conditions (outdoor) from October 1 (day length 11 h 50 min) to November 30 (day length 10 h 12 min). Representative animals from each group were killed at 3-hour intervals with additional time points near the onset of light. Weights of the paired gonads and accessory organs revealed that all of the animals kept outdoors and none of those kept indoors underwent reproductive regression. Significant circadian rhythms were observed in serum luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin (PRL), thyrotropin (TSH), thyroxine (T-4), triiodothyronine (T-3) and testosterone in indoor and outdoor-housed hamsters. The 24-hour acrophase in serum LH, TSH, T-4 and T-3 occurred between 13.00 and 16.00 h, while that of serum testosterone and PRL occurred between 18.00 and 20.00 h in indoor hamsters. Hormonal variables in which there was a significant alteration in the 24-hour acrophase of outdoor animals relative to that in the indoor animals included pituitary PRL and serum testosterone, PRL, FSH and TSH. Hamsters housed indoors had a significant rhythm in brown adipose tissue type-II 5'-deiodinase activity, but no rhythm was evident in this tissue in outdoor animals. The natural autumnal conditions depressed serum LH and testosterone around the clock, though the depression of serum FSH relative to indoor hamster values was best seen between 09.00 and 21.00 h and that for PRL between 15.00 and 24.00 h. The overall lower T-4 and higher T-3 and type-II 5'-deiodinase in brown adipose tissue in the outdoor group suggest a role for accelerated peripheral conversion of T-4 in producing the thyroid hormone changes of autumn conditions. C1 UNIV OVIEDO,DEPT MORFOL & BIOL CELULAR,E-33006 OVIEDO,SPAIN. UNIV ALBERTA,DEPT ANAT & CELL BIOL,EDMONTON,AB,CANADA. USA,INST SURG RES,FT SAM HOUSTON,TX 78234. ABILENE CHRISTIAN UNIV,DEPT BIOL,ABILENE,TX. RP VAUGHAN, MK (reprint author), UNIV TEXAS,HLTH SCI CTR,DEPT CELLULAR & STRUCT BIOL,7703 FLOYD CURL DR,SAN ANTONIO,TX 78284, USA. NR 36 TC 8 Z9 8 U1 0 U2 0 PU KARGER PI BASEL PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND SN 0028-3835 J9 NEUROENDOCRINOLOGY JI Neuroendocrinology PD JUL PY 1994 VL 60 IS 1 BP 96 EP 104 DI 10.1159/000126725 PG 9 WC Endocrinology & Metabolism; Neurosciences SC Endocrinology & Metabolism; Neurosciences & Neurology GA NV385 UT WOS:A1994NV38500013 PM 8090288 ER PT J AU PHELPS, JY WARD, JA SZIGETI, J BOWLAND, CH MAYER, AR AF PHELPS, JY WARD, JA SZIGETI, J BOWLAND, CH MAYER, AR TI CERVICAL CONE MARGINS AS A PREDICTOR FOR RESIDUAL DYSPLASIA IN POST-CONE HYSTERECTOMY SPECIMENS SO OBSTETRICS AND GYNECOLOGY LA English DT Article ID CARCINOMA INSITU; UTERINE CERVIX; CONIZATION AB Objective: To determine the relation between dysplasia at cervical cone margins and the presence or absence of residual dysplasia in post-cone hysterectomy specimens. Methods: We performed a 6-year retrospective, multicenter study and reviewed 250 cases in which the patient had a cold-knife cervical cone biopsy followed by a hysterectomy within 6 months. Pathology reports from 23 institutions described the margins in conization specimens and the subsequent status of residual dysplasia in the hysterectomy specimens. Results: There was a statistically significant difference in the prevalence of residual dysplasia in hysterectomy specimens between patients with positive margins on cone biopsy (47%) and those with negative margins (23%) (P < .01), The positive predictive value for residual dysplasia given positive cone margins was 47%, and the negative predictive value was 77%. The grade of post-cone residual dysplasia increased commensurately with the grade of dysplasia in the conization specimen. Conclusions: The presence of dysplasia at the cervical cone margin relates significantly with the presence of residual dysplasia in the post-tone hysterectomy specimen. The grade of residual dysplasia in the post-tone hysterectomy specimen increased as the grade of dysplasia in the conization specimen increased. Free margins on a cone biopsy specimen with dysplasia offer reassurance that invasive cancer is not present in the remaining uterus. C1 WILLIAM BEAUMONT ARMY MED CTR,EL PASO,TX 79920. RP PHELPS, JY (reprint author), BROOKE ARMY MED CTR,DEPT OBSTET & GYNECOL,FT SAM HOUSTON,TX 78234, USA. NR 11 TC 35 Z9 37 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0029-7844 J9 OBSTET GYNECOL JI Obstet. Gynecol. PD JUL PY 1994 VL 84 IS 1 BP 128 EP 130 PG 3 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA PH953 UT WOS:A1994PH95300026 PM 8008307 ER PT J AU LETTERIE, GS MORGENSTERN, LL JOHNSON, L AF LETTERIE, GS MORGENSTERN, LL JOHNSON, L TI THE ROLE OF AN ELECTRONIC MAIL SYSTEM IN THE EDUCATIONAL-STRATEGIES OF A RESIDENCY IN OBSTETRICS AND GYNECOLOGY SO OBSTETRICS AND GYNECOLOGY LA English DT Article ID COMPUTER; NETWORKS; SCIENCE AB Computerized electronic mail (E-mail) systems provide a rapid means of data sharing and are used in a variety of commercial and industrial settings for the widespread distribution of memoranda. We adapted an E-mail system to our program to determine the feasibility of incorporating such a system into didactic resident education in obstetrics and gynecology and to assess resident response to this form of computer-based learning. The system was programmed to distribute one review question per day to 24 resident physicians for 60 days. Residents were given 24 hours to respond and comment. Each question was discussed and appropriate references distributed within 48 hours of presentation. All questions and responses were then stored in an electronic file folder for later review. An examination was given at completion of the project (post-test), and these scores were compared to performance during the project (pre-test). An anonymous questionnaire was distributed upon completion of the project to assess the residents' overall satisfaction with the program. The system was well received by the residents. On a scale of 1 to 6 (1 = lowest; 6 = highest), resident satisfaction was high, with an overall average rating of 5.0. Using this scale, residents assessed their frustration level as 1.5. Average daily participation was 85%. An average of 9 minutes was required to complete each question and review prior responses and discussion; this interval was not significantly different among the postgraduate years. Scores on the examination at project completion were significantly higher than performance during the project. Implementation of computer-based training such as this represents a necessary and early step toward realizing full use of such systems for our resident education programs. C1 TRIPLER ARMY MED CTR,DEPT OBSTET & GYNECOL,HONOLULU,HI 96859. NR 12 TC 15 Z9 15 U1 0 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0029-7844 J9 OBSTET GYNECOL JI Obstet. Gynecol. PD JUL PY 1994 VL 84 IS 1 BP 137 EP 139 PG 3 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA PH953 UT WOS:A1994PH95300028 PM 8008309 ER PT J AU SANGHADASA, M ERBACH, PS SUNG, CC GREGORY, DA FRIDAY, WA AF SANGHADASA, M ERBACH, PS SUNG, CC GREGORY, DA FRIDAY, WA TI WAVELET TRANSFORM APPLIED TO SYNTHETIC-APERTURE RADAR OPTICAL IMPLEMENTATION AND ADAPTIVE TECHNIQUES SO OPTICAL ENGINEERING LA English DT Article DE ADAPTIVE WAVELET TRANSFORMS; SYNTHETIC APERTURE RADAR; OPTICAL WAVELET TRANSFORM; ADAPTIVE SIGNAL PROCESSING ID OBJECTS AB The wavelet transform is applied to signal processing of synthetic aperture radar and techniques for determining the range, cross-range, and rotation of the target as well as adaptive process for better resolution are studied. We also optically implement the wavelet transform in the laboratory for real-time processing of radar data, and describe methods for adaptive processing. C1 USA,CTR MISSILE COMMAND RD&E,AMSMI RD WS PO,REDSTONE ARSENAL,AL 35898. RP SANGHADASA, M (reprint author), UNIV ALABAMA,DEPT PHYS,HUNTSVILLE,AL 35899, USA. NR 10 TC 5 Z9 5 U1 0 U2 0 PU SOC PHOTO-OPT INSTRUM ENG PI BELLINGHAM PA PO BOX 10, BELLINGHAM, WA 98227-0010 SN 0091-3286 J9 OPT ENG JI Opt. Eng. PD JUL PY 1994 VL 33 IS 7 BP 2282 EP 2289 DI 10.1117/12.172241 PG 8 WC Optics SC Optics GA NX463 UT WOS:A1994NX46300024 ER PT J AU CHANDNANI, VP HARPER, MT FICKE, JR GAGLIARDI, JA ROLLING, L CHRISTENSEN, KP HANSEN, MF AF CHANDNANI, VP HARPER, MT FICKE, JR GAGLIARDI, JA ROLLING, L CHRISTENSEN, KP HANSEN, MF TI CHRONIC ANKLE INSTABILITY - EVALUATION WITH MR ARTHROGRAPHY, MR-IMAGING, AND STRESS RADIOGRAPHY SO RADIOLOGY LA English DT Article DE ANKLE, INJURIES; ANKLE, MR; LIGAMENTS, INJURIES; MAGNETIC RESONANCE (MR), ARTHROGRAPHY; MAGNETIC RESONANCE (MR), COMPARATIVE STUDIES; MAGNETIC RESONANCE (MR), CONTRAST ENHANCEMENT ID LIGAMENT INJURIES; LATERAL LIGAMENTS; DIAGNOSIS AB PURPOSE: To compare the efficacy of conventional magnetic resonance (MR) imaging, MR arthrography, and stress radiography in the detection of lateral collateral ligament abnormalities in patients with chronic ankle instability. MATERIALS AND METHODS: Seventeen patients with chronic lateral ankle instability underwent stress radiography, MR imaging, and MR arthrography after intraarticular injection of gadopentetate dimeglumine. Imaging findings were correlated with surgical findings. RESULTS: The anterior talofibular (ATF) ligament was torn in 14 patients, and the calcaneofibular (CF) ligament was torn in 10. MR arthrography was more accurate and sensitive in the detection of ATF tears than was MR imaging or stress radiography (P less than or equal to .05). Associated injuries were detected with both MR imaging and MR arthrography. CONCLUSION: MR arthrography is a sensitive technique for detecting and staging tears of the lateral collateral ligaments. C1 TRIPLER ARMY MED CTR,DEPT ORTHOPAED SURG,HONOLULU,HI 96859. RP CHANDNANI, VP (reprint author), TRIPLER ARMY MED CTR,DEPT RADIOL,HSHK DR,HONOLULU,HI 96859, USA. NR 21 TC 95 Z9 98 U1 0 U2 4 PU RADIOLOGICAL SOC NORTH AMER PI EASTON PA 20TH AND NORTHAMPTON STS, EASTON, PA 18042 SN 0033-8419 J9 RADIOLOGY JI Radiology PD JUL PY 1994 VL 192 IS 1 BP 189 EP 194 PG 6 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA NT031 UT WOS:A1994NT03100034 PM 8208935 ER PT J AU CANCIO, LC WORTHAM, WG ZIMBA, F AF CANCIO, LC WORTHAM, WG ZIMBA, F TI HYPOTHERMIA IN ACUTE BLUNT HEAD-INJURY SO RESUSCITATION LA English DT Review DE HEAD INJURIES, CLOSED; BRAIN INJURIES; HYPOTHERMIA, INDUCED AB Mild to moderate hypothermia has been employed since the 1940s in the treatment of acute blunt head trauma. The utility of hypothermia in ischemic injury has been confirmed, by both animal studies and clinical experience, in cardiovascular and neurological surgery. In blunt injury, though, only one prospective, randomized study has shown a statistically significant improvement in long term outcome. Clinical experience, animal data, proposed mechanisms, technical considerations, and potential risks are reviewed. Hypothermia remains controversial in the setting of blunt head injury but may prove to be a useful treatment modality. RP CANCIO, LC (reprint author), BROOKE ARMY MED CTR,GEN SURG SERV,FT SAM HOUSTON,TX 78234, USA. NR 0 TC 12 Z9 14 U1 0 U2 0 PU ELSEVIER SCI IRELAND LTD PI CLARE PA CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE, IRELAND SN 0300-9572 J9 RESUSCITATION JI Resuscitation PD JUL PY 1994 VL 28 IS 1 BP 9 EP 19 DI 10.1016/0300-9572(94)90049-3 PG 11 WC Critical Care Medicine; Emergency Medicine SC General & Internal Medicine; Emergency Medicine GA PE041 UT WOS:A1994PE04100002 PM 7809490 ER PT J AU LIN, SS YIP, PW AF LIN, SS YIP, PW TI ION-BEAM MODIFICATION OF CARBON-FIBER SO SAMPE JOURNAL LA English DT Article ID CHEMISTRY; NI(111); CH4 AB The ion beams generated from gases, methane-hydrogen, oxygen, and nitrogen in a low voltage ion source with kinetic energy 400-1,000 eV, were used to modify the surfaces of commercial carbon fibers. After the ion treatments, single filament tensile stress as well as fiber-epoxy interfacial adhesive strength was found to increase substantially. The modification by ion beams results in profound alterations of surface morphology and topology. The enhanced mechanical properties of carbon fibers are discussed from fiber surface microstructures acid ion beam processing parameters. C1 USA,RES LAB,MAT DIRECTORATE,WATERTOWN,MA. NR 17 TC 0 Z9 0 U1 0 U2 0 PU SAMPE PUBLISHERS PI COVINA PA 1161 PARKVIEW DRIVE, COVINA, CA 91722 SN 0091-1062 J9 SAMPE J JI Sampe J. PD JUL-AUG PY 1994 VL 30 IS 4 BP 52 EP 60 PG 9 WC Engineering, Multidisciplinary; Materials Science, Multidisciplinary SC Engineering; Materials Science GA QZ180 UT WOS:A1994QZ18000007 ER PT J AU KARK, JA WARD, FT AF KARK, JA WARD, FT TI EXERCISE AND HEMOGLOBIN-S SO SEMINARS IN HEMATOLOGY LA English DT Review ID SICKLE-CELL TRAIT; ACUTE RENAL-FAILURE; ACUTE SPLENIC SEQUESTRATION; MODERATELY HIGH-ALTITUDE; ACUTE TUBULAR-NECROSIS; SUDDEN CARDIAC DEATH; ARMED-FORCES; RISK FACTOR; C-DISEASE; GLUCOSE-6-PHOSPHATE-DEHYDROGENASE DEFICIENCY C1 WALTER REED ARMY MED CTR,DEPT MED,HEMATOL ONCOL SERV,WASHINGTON,DC 20307. RP KARK, JA (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT CLIN PHYSIOL,DIV MED,BLDG 40,WASHINGTON,DC 20307, USA. NR 266 TC 86 Z9 87 U1 2 U2 6 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0037-1963 J9 SEMIN HEMATOL JI Semin. Hematol. PD JUL PY 1994 VL 31 IS 3 BP 181 EP 225 PG 45 WC Hematology SC Hematology GA NX274 UT WOS:A1994NX27400001 PM 7973777 ER PT J AU SMITH, DD WYBOURNE, M WU, JC DEANNI, A LEMEUNE, LM MOERKIRK, RP CHANG, WH FOTIADIS, L AF SMITH, DD WYBOURNE, M WU, JC DEANNI, A LEMEUNE, LM MOERKIRK, RP CHANG, WH FOTIADIS, L TI A NOVEL TECHNIQUE FOR THE STUDY OF DEFECTS USING QUANTUM WIRES SO SOLID STATE COMMUNICATIONS LA English DT Article ID DIMENSIONAL ELECTRON-GAS; POINT CONTACTS; RESISTANCE; NOISE AB A technique utilizing changes in the conductance of a quantum wire to measure the detrapping time and density of electron traps is described. The technique permits the study of defects in heterostructure material over a wide range of doping levels and under a variety of conditions. The technique also introduces the possibility of studying one microsecond or faster (de)trapping times. C1 UNIV OREGON,DEPT PHYS,EUGENE,OR 97403. GEOCENTERS INC,LAKE HOPATCONG,NJ 07849. RP SMITH, DD (reprint author), USA,RES LAB,EF,EP,AMSRL,EPSD,FT MONMOUTH,NJ 07703, USA. NR 13 TC 3 Z9 3 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0038-1098 J9 SOLID STATE COMMUN JI Solid State Commun. PD JUL PY 1994 VL 91 IS 4 BP 313 EP 317 DI 10.1016/0038-1098(94)90308-5 PG 5 WC Physics, Condensed Matter SC Physics GA NW455 UT WOS:A1994NW45500009 ER PT J AU BONATZ, E AF BONATZ, E TI THE GERMAN HEALTH-CARE SYSTEM SO SOUTHERN MEDICAL JOURNAL LA English DT Letter RP BONATZ, E (reprint author), USA,MED CORPS,DIV ORTHOPAED SURG,601 MED EDUC BLDG,1813 6TH AVE S,BIRMINGHAM,AL 35294, USA. NR 3 TC 0 Z9 0 U1 0 U2 0 PU SOUTHERN MEDICAL ASSN PI BIRMINGHAM PA 35 LAKESHORE DR PO BOX 190088, BIRMINGHAM, AL 35219 SN 0038-4348 J9 SOUTHERN MED J JI South.Med.J. PD JUL PY 1994 VL 87 IS 7 BP 771 EP 771 DI 10.1097/00007611-199407000-00024 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA NW449 UT WOS:A1994NW44900024 PM 8023219 ER PT J AU ROY, MJ AF ROY, MJ TI THE GERMAN HEALTH-CARE SYSTEM - REPLY SO SOUTHERN MEDICAL JOURNAL LA English DT Letter RP ROY, MJ (reprint author), USA,MED CORPS,KIMBROUGH ARMY COMMUNITY HOSP,DEPT MED,FT GEORGE G MEADE,MD 20755, USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU SOUTHERN MEDICAL ASSN PI BIRMINGHAM PA 35 LAKESHORE DR PO BOX 190088, BIRMINGHAM, AL 35219 SN 0038-4348 J9 SOUTHERN MED J JI South.Med.J. PD JUL PY 1994 VL 87 IS 7 BP 771 EP 771 DI 10.1097/00007611-199407000-00025 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA NW449 UT WOS:A1994NW44900025 ER PT J AU HIRVONEN, JK AF HIRVONEN, JK TI CURRENT TOPICS OF ION-BEAM RESEARCH-AND-DEVELOPMENT SO SURFACE & COATINGS TECHNOLOGY LA English DT Article; Proceedings Paper CT 8th International Conference on Surface Modification of Metals by Ion Beams CY SEP 13-17, 1993 CL KANAZAWA, JAPAN SP INST PHYS & CHEM RES, IND RES INST ISHIKAWA, JAPANESE SOC SURFACE LAYER MODIFICAT ION IMPLANTAT, BEAM ENGN RES SOC JAPAN, AMADA FDN MET WORK TECHNOL, KANAZAWA CONVENT BUR, JAPAN SOC APPL PHYS, CHEM SOC JAPAN, JAPAN INST MET, JAPAN SOC PRECIS ENGN, IRON & STEEL INST JAPAN, ELECTROCHEM SOC JAPAN, INST ELECT ENGINEERS JAPAN, VACUUM SOC JAPAN, SURFACE SCI SOC JAPAN, SURFACE FINISHING SOC JAPAN ID THIN-FILM DEPOSITION; ASSISTED DEPOSITION; COATINGS; STEEL AB The use of directed energetic ion beams to improve the surface-sensitive properties of materials has been pursued worldwide for almost two decades. In that time, numerous examples of property improvements have been demonstrated in the laboratory and some applications are currently finding commercial uses. Among these current topics of transitional R&D are nitrogen ion implantation to impart wear resistance to precision components, including titanium alloy surgical prostheses and selected tooling. The hybrid combination of ion beam bombardment in conjunction with physical vapor deposition, commonly termed ion-beam-assisted deposition (IBAD), has emerged as a powerful processing technique. It combines many of the positive attributes of ion beam and conventional coating technologies, such as high density, superior adhesion and the ability to produce arbitrarily thick coatings. An important feature of IBAD technology is its frequently demonstrated ability to control many generic properties of coatings, such as the morphology, adhesion, residual stress and stoichiometry. Current applications of ion beam processing for the production of wear-, corrosion- and fatigue-resistant surfaces are presented here with an emphasis on those pertaining to US Army needs. RP HIRVONEN, JK (reprint author), USA,RES LAB,MAT DIRECTORATE,WATERTOWN,MA 02172, USA. NR 35 TC 10 Z9 11 U1 0 U2 1 PU ELSEVIER SCIENCE SA LAUSANNE PI LAUSANNE 1 PA PO BOX 564, 1001 LAUSANNE 1, SWITZERLAND SN 0257-8972 J9 SURF COAT TECH JI Surf. Coat. Technol. PD JUL PY 1994 VL 65 IS 1-3 BP 84 EP 89 DI 10.1016/S0257-8972(94)80013-8 PG 6 WC Materials Science, Coatings & Films; Physics, Applied SC Materials Science; Physics GA NX760 UT WOS:A1994NX76000014 ER PT J AU SATAVA, RM ELLIS, SR AF SATAVA, RM ELLIS, SR TI HUMAN INTERFACE TECHNOLOGY - AN ESSENTIAL TOOL FOR THE MODERN SURGEON SO SURGICAL ENDOSCOPY-ULTRASOUND AND INTERVENTIONAL TECHNIQUES LA English DT Article DE ROBOTICS; TELEPRESENCE; VIRTUAL REALITY; HUMAN INTERFACE TECHNOLOGY; ERGONOMICS AB Human interface technology is a new science which must be understood by all surgeons in order to cope with the ever-increasing complexity of surgical practice. This science is the understanding of how humans comprehend, interact, and use the world around them. The increasing use of robotics, computers, and virtual reality depend upon this technology to create a ''user-friendly'' environment to be able to assimilate the massive amount of data and images and to ''naturally'' interact with machines and computers. Through careful implementation, more complex systems will become easier to use and enhance the surgeon-the technology must adapt to the surgeon, not the reverse. RP SATAVA, RM (reprint author), WALTER REED ARMY MED CTR,WASHINGTON,DC 20307, USA. NR 0 TC 24 Z9 24 U1 1 U2 3 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0930-2794 J9 SURG ENDOSC-ULTRAS JI Surg. Endosc.-Ultrason. Interv. Tech. PD JUL PY 1994 VL 8 IS 7 BP 817 EP 820 DI 10.1007/BF00593450 PG 4 WC Surgery SC Surgery GA NX662 UT WOS:A1994NX66200020 PM 7974116 ER PT J AU KAVOUSSI, LR MOORE, RG PARTIN, AW BENDER, JS ZENILMAN, ME SATAVA, RM AF KAVOUSSI, LR MOORE, RG PARTIN, AW BENDER, JS ZENILMAN, ME SATAVA, RM TI TELEROBOTIC ASSISTED LAPAROSCOPIC SURGERY - INITIAL LABORATORY AND CLINICAL-EXPERIENCE SO UROLOGY LA English DT Note ID CHOLECYSTECTOMY AB Objectives. To assess the feasibility of telerobotic assisted surgery. Methods. In a laboratory model, a cholecystectomy, splenectomy, and nephrectomy were performed by an inexperienced surgeon who was being mentored by an experienced surgeon stationed at a remote site. The remote surgeon controlled the laparoscopic camera by utilizing a telerobotic system. In patients, laparoscopic cholecystectomy, varix ligation, and bladder suspension were performed by an experienced team utilizing a robotic system controlled by an experienced surgeon from a remote site. Results. In both the laboratory and clinical setting, all procedures were successfully completed without complications. Conclusions. Current technology is available to successfully allow for telerobotic assisted surgery. C1 WALTER REED ARMY MED CTR,DEPT SURG,WASHINGTON,DC 20307. RP KAVOUSSI, LR (reprint author), JOHNS HOPKINS BAYVIEW MED CTR,BRADY UROL INST,4940 EASTERN AVE,BALTIMORE,MD 21224, USA. NR 16 TC 80 Z9 82 U1 0 U2 3 PU CAHNERS PUBL CO PI NEW YORK PA 249 WEST 17 STREET, NEW YORK, NY 10011 SN 0090-4295 J9 UROLOGY JI UROLOGY PD JUL PY 1994 VL 44 IS 1 BP 15 EP 19 DI 10.1016/S0090-4295(94)80003-0 PG 5 WC Urology & Nephrology SC Urology & Nephrology GA NX089 UT WOS:A1994NX08900003 PM 8042260 ER PT J AU MOUL, JW AF MOUL, JW TI DNA-PLOIDY IN NONSEMINOMATOUS GERM-CELL TESTICULAR-TUMOR SO UROLOGY LA English DT Letter ID STAGE-I C1 UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. RP MOUL, JW (reprint author), WALTER REED ARMY MED CTR,WASHINGTON,DC 20307, USA. NR 4 TC 0 Z9 0 U1 0 U2 0 PU CAHNERS PUBL CO PI NEW YORK PA 249 WEST 17 STREET, NEW YORK, NY 10011 SN 0090-4295 J9 UROLOGY JI UROLOGY PD JUL PY 1994 VL 44 IS 1 BP 151 EP 152 DI 10.1016/S0090-4295(94)80037-5 PG 2 WC Urology & Nephrology SC Urology & Nephrology GA NX089 UT WOS:A1994NX08900040 PM 8042262 ER PT J AU MILLER, AC LEI, J TOM, J AF MILLER, AC LEI, J TOM, J TI SHELL STRENGTH OF THE NON-INDIGENOUS ZEBRA MUSSEL DREISSENA-POLYMORPHA (PALLAS) IN COMPARISON TO 2 OTHER FRESH-WATER BIVALVE SPECIES SO VELIGER LA English DT Note RP MILLER, AC (reprint author), USA,ENGINEER WATERWAYS EXPT STN,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 10 TC 5 Z9 5 U1 0 U2 2 PU CALIF MALACOZOOLOGICAL SOC INC PI SANTA BARBARA PA SANTA BARBARA MUSEUM NATURAL HISTORY, 2559 PUESTA DEL SOL RD, SANTA BARBARA, CA 93105 SN 0042-3211 J9 VELIGER JI Veliger PD JUL 1 PY 1994 VL 37 IS 3 BP 319 EP 321 PG 3 WC Marine & Freshwater Biology; Zoology SC Marine & Freshwater Biology; Zoology GA NV747 UT WOS:A1994NV74700009 ER PT J AU DAVIS, KJ BELL, RC WILHELMSEN, CL LANGFORD, MJ MONTALI, RJ AF DAVIS, KJ BELL, RC WILHELMSEN, CL LANGFORD, MJ MONTALI, RJ TI IMMUNOHISTOCHEMICAL ANALYSIS OF SPONTANEOUS PANCREATIC-ISLET AMYLOID DEPOSITS IN NONHUMAN-PRIMATES SO VETERINARY PATHOLOGY LA English DT Note DE AMYLOID; DIABETES; IMMUNOHISTOCHEMISTRY; ISLETS; PANCREAS; PRIMATES ID DIABETES-MELLITUS; INSULAR AMYLOIDOSIS; POLYPEPTIDE; PAP RP DAVIS, KJ (reprint author), USA,MED RES INST INFECT DIS,DIV PATHOL,FREDERICK,MD 21702, USA. NR 9 TC 6 Z9 6 U1 0 U2 0 PU AMER COLL VET PATHOLOGIST PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 SN 0300-9858 J9 VET PATHOL JI Vet. Pathol. PD JUL PY 1994 VL 31 IS 4 BP 479 EP 480 PG 2 WC Pathology; Veterinary Sciences SC Pathology; Veterinary Sciences GA NW196 UT WOS:A1994NW19600014 PM 7941241 ER PT J AU HELMBOLD, RL AF HELMBOLD, RL TI THE CONSTANT FALLACY - A PERSISTENT LOGICAL FLAW IN APPLICATIONS OF LANCHESTER EQUATIONS SO EUROPEAN JOURNAL OF OPERATIONAL RESEARCH LA English DT Article DE METHODOLOGY; MODELING; MILITARY; PRACTICE; LANCHESTER EQUATIONS AB A particular logical flaw is continually being made in interpretations of Lanchester's equations. The fallacy will be exposed in this paper. Because of this fallacy, certain applications of Lanchester's N-square law of combat are invalid. Also, a popular method for empirically determining the functional form of the attrition equations is invalid. Correct interpretations of this situation are offered, and a logically sound approach is indicated. RP HELMBOLD, RL (reprint author), USA,CONCEPTS ANAL AGCY,8120 WOODMONT AVE,BETHESDA,MD 20814, USA. NR 34 TC 2 Z9 2 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0377-2217 J9 EUR J OPER RES JI Eur. J. Oper. Res. PD JUN 30 PY 1994 VL 75 IS 3 BP 647 EP 658 DI 10.1016/0377-2217(94)90303-4 PG 12 WC Management; Operations Research & Management Science SC Business & Economics; Operations Research & Management Science GA NX553 UT WOS:A1994NX55300015 ER PT J AU ELSTON, DM AF ELSTON, DM TI HEALTH-RELATED CLAIMS AT FAST-FOOD CHAINS SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Letter RP ELSTON, DM (reprint author), BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234, USA. NR 2 TC 0 Z9 0 U1 0 U2 0 PU MASS MEDICAL SOC PI BOSTON PA 10 SHATTUCK, BOSTON, MA 02115 SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD JUN 30 PY 1994 VL 330 IS 26 BP 1908 EP 1908 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA NT530 UT WOS:A1994NT53000030 PM 8196744 ER PT J AU VARGHESE, A WINSLOW, RL AF VARGHESE, A WINSLOW, RL TI DYNAMICS OF ABNORMAL PACEMAKING ACTIVITY IN CARDIAC PURKINJE-FIBERS SO JOURNAL OF THEORETICAL BIOLOGY LA English DT Article ID CALCIUM RELEASE; SARCOPLASMIC-RETICULUM; CARDIOTONIC STEROIDS; CELLULAR MECHANISMS; TRANSIENT; HEART; AFTERDEPOLARIZATIONS; ELECTROPHYSIOLOGY; STROPHANTHIDIN; CONTRACTION C1 UNIV MINNESOTA,DEPT BIOMED ENGN,MINNEAPOLIS,MN 55415. JOHNS HOPKINS UNIV,DEPT BIOMED ENGN,BALTIMORE,MD. RP VARGHESE, A (reprint author), UNIV MINNESOTA,ARMY HIGH PERFORMANCE COMP RES CTR,1100 WASHINGTON AVE S,MINNEAPOLIS,MN 55415, USA. NR 38 TC 20 Z9 20 U1 0 U2 1 PU ACADEMIC PRESS LTD PI LONDON PA 24-28 OVAL RD, LONDON, ENGLAND NW1 7DX SN 0022-5193 J9 J THEOR BIOL JI J. Theor. Biol. PD JUN 21 PY 1994 VL 168 IS 4 BP 407 EP 420 DI 10.1006/jtbi.1994.1121 PG 14 WC Biology; Mathematical & Computational Biology SC Life Sciences & Biomedicine - Other Topics; Mathematical & Computational Biology GA NU372 UT WOS:A1994NU37200007 PM 8072299 ER PT J AU SARGENT, AL ALMLOF, J LIBERKO, CA AF SARGENT, AL ALMLOF, J LIBERKO, CA TI ELECTRON DELOCALIZATION IN HELICAL BIS(QUINONE) ANION-RADICALS SO JOURNAL OF PHYSICAL CHEMISTRY LA English DT Article ID SPECTRA AB Ab initio quantum chemical calculations were employed to determine the extent of charge localization in the anion radicals of helical bis(quinones). Recent experimental evidence has suggested that the electronic charge in these systems is delocalized, in contrast to that in their linear analogs. The optimized molecular geometries of the neutral and radical anion five- and seven-ring bis(quinones) reveal unusual supershort nonbonded contacts between the outermost rings and large positive electron affinities. The regular helicenes, in contrast, lack the short contacts and have no electron affinities at the SCF level of theory Of central importance to these short contacts is the interaction between the 2 pi* orbitals of the carbonyls on the Inner edge of the helicene, characteristic only of the five-ring complex, or, for the larger systems, between the pi systems of the overlapping rings at the opposite end of the helicene, of which the inner carbonyl 2 pi* orbitals are principal components. The theoretical results suggest that the electronic charge in the helical bis(quinone) anion radicals is best described as delocalized. C1 UNIV MINNESOTA,DEPT CHEM,MINNEAPOLIS,MN 55455. USA,HIGH PERFORMANCE COMP RES CTR,MINNEAPOLIS,MN 55415. MINNESOTA SUPERCOMP INST,MINNEAPOLIS,MN 55415. NR 16 TC 2 Z9 2 U1 1 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0022-3654 J9 J PHYS CHEM-US JI J. Phys. Chem. PD JUN 16 PY 1994 VL 98 IS 24 BP 6114 EP 6117 DI 10.1021/j100075a012 PG 4 WC Chemistry, Physical SC Chemistry GA NT180 UT WOS:A1994NT18000012 ER PT J AU FISHER, CJ DHAINAUT, JFA OPAL, SM PRIBBLE, JP BALK, RA SLOTMAN, GJ IBERTI, TJ RACKOW, EC SHAPIRO, MJ GREENMAN, RL REINES, HD SHELLY, MP THOMPSON, BW LABRECQUE, JF CATALANO, MA KNAUS, WA SADOFF, JC ASTIZ, M CARPATI, C BONE, RC FREIDMAN, B MURE, AJ BRATHWAITE, C SHAPIRO, E MELHORN, L TAYLOR, R KEEGAN, M OBRIEN, J SCHEIN, R PENA, M WASSERLOUF, M OROPELLO, J BENJAMIN, E DELGUIDICE, R EMMANUEL, G LIE, T ANDERSON, L MARSHALL, J DEMAJO, W ROTSTEIN, O FOSTER, D ABRAHAM, E MIDDLETON, H PERRY, C LEVY, H FRY, DE SIMPSON, SQ CROWELL, RE NEIDHART, M STEVENS, D COFFMAN, T NARASIMHAM, N MERRICK, DK BERGQUIST, W MATZEL, KE HUEBLER, M FOULKE, GE ALBERTSON, TE WALBY, WF ALLEN, RP BAUGHMAN, R HASSELGREN, PO FINK, MP FAVORITO, F THOMPSON, BT CORBIN, R SHELLHORSE, GY FRAZIER, A WHITE, S GARRARD, C ACOURT, C STORER, S GERVICH, DH FOSHE, D BRASE, R BAGDAHN, A COONEY, R SMITH, JS MARTIN, LF VINCENT, JL FRIEDMAN, G BERLOT, G FLETCHER, JR WILLIAMS, MD WRIGHT, TF JOHNSON, S FEILD, C WOLF, K MACINTYRE, N DUBIN, HG DURKIN, MR DUBIN, PK STAUBACH, KH FEIN, AM SCHULMAN, DB NIEDERMAN, MS CHALFIN, DB VANLEEUWEN, PAM BOERMEESTER, MA SCHNEIDER, AJ BANDER, J IMM, A BERNARD, G NELSON, L STROUD, M SAFCSAK, K CERRA, F RINDAL, J MANN, H HALPERN, N SILVERSTEIN, J ALICEA, M SIBBALD, WJ MARTIN, CM RUTLEDGE, FS PETTI, K RUSSELL, JA KRUGER, R DRUMMOND, A LANGE, P SEIFERT, T DUROCHER, A TENAILLON, A BOITEAU, R LHERM, T LOWRY, SF COYLE, SM BARIE, PS DEMARIA, E SNYDMAN, DR SCHWAITZBERG, SD NASRAWAY, SA GRINDLINGER, J SUMMER, W DEBOISBLANC, B WAHL, M ALESTIG, K GROSSMAN, J MAKI, D PAZ, HL WEINER, M BIHARI, D CAMPBELL, D BLEICHNER, G DAHN, MS LANGE, MPA HALL, J POHLMAN, A WENZEL, RP GROSSERODE, M COSTIGAN, M MILESKI, W WEIGELT, J YESTON, N IRIZARRY, C ROSS, J ROBBINS, J NIGHTINGALE, P OWEN, K SANDSTEDT, S BERG, S SIMON, GL SENEFF, MG CONRY, KM ZIMMERMAN, JL DELLINGER, RP JOHNSTON, R ALLEE, P GRANDE, PO MYHRE, E DHAINAUT, JF HAMY, I MIRA, JP HARMON, J WHITE, J MCKIE, L SILVERMAN, H TUMA, P BENNETT, D PORTER, JC LAURELL, MH JACOBS, S ASH, S STILES, DM PRIOR, MJ KNATTERUD, G TERRIN, M KUFERA, J WILKENS, P RA, K MONROE, L SPRUNG, C HAMILTON, CM MATTHAY, R MCCABE, W TONASCIA, J WIEDEMAN, H WITTES, J CAMPION, GV CROFT, CR LUSTICK, R LOOKABAUGH, J GORDON, GS NOE, L BLOEDOW, D SMITH, CG BRANNON, D KUSH, R NG, D MOORE, E BAZEMORE, K GALVAN, M WAGNER, D HARRELL, F STABLEIN, D AF FISHER, CJ DHAINAUT, JFA OPAL, SM PRIBBLE, JP BALK, RA SLOTMAN, GJ IBERTI, TJ RACKOW, EC SHAPIRO, MJ GREENMAN, RL REINES, HD SHELLY, MP THOMPSON, BW LABRECQUE, JF CATALANO, MA KNAUS, WA SADOFF, JC ASTIZ, M CARPATI, C BONE, RC FREIDMAN, B MURE, AJ BRATHWAITE, C SHAPIRO, E MELHORN, L TAYLOR, R KEEGAN, M OBRIEN, J SCHEIN, R PENA, M WASSERLOUF, M OROPELLO, J BENJAMIN, E DELGUIDICE, R EMMANUEL, G LIE, T ANDERSON, L MARSHALL, J DEMAJO, W ROTSTEIN, O FOSTER, D ABRAHAM, E MIDDLETON, H PERRY, C LEVY, H FRY, DE SIMPSON, SQ CROWELL, RE NEIDHART, M STEVENS, D COFFMAN, T NARASIMHAM, N MERRICK, DK BERGQUIST, W MATZEL, KE HUEBLER, M FOULKE, GE ALBERTSON, TE WALBY, WF ALLEN, RP BAUGHMAN, R HASSELGREN, PO FINK, MP FAVORITO, F THOMPSON, BT CORBIN, R SHELLHORSE, GY FRAZIER, A WHITE, S GARRARD, C ACOURT, C STORER, S GERVICH, DH FOSHE, D BRASE, R BAGDAHN, A COONEY, R SMITH, JS MARTIN, LF VINCENT, JL FRIEDMAN, G BERLOT, G FLETCHER, JR WILLIAMS, MD WRIGHT, TF JOHNSON, S FEILD, C WOLF, K MACINTYRE, N DUBIN, HG DURKIN, MR DUBIN, PK STAUBACH, KH FEIN, AM SCHULMAN, DB NIEDERMAN, MS CHALFIN, DB VANLEEUWEN, PAM BOERMEESTER, MA SCHNEIDER, AJ BANDER, J IMM, A BERNARD, G NELSON, L STROUD, M SAFCSAK, K CERRA, F RINDAL, J MANN, H HALPERN, N SILVERSTEIN, J ALICEA, M SIBBALD, WJ MARTIN, CM RUTLEDGE, FS PETTI, K RUSSELL, JA KRUGER, R DRUMMOND, A LANGE, P SEIFERT, T DUROCHER, A TENAILLON, A BOITEAU, R LHERM, T LOWRY, SF COYLE, SM BARIE, PS DEMARIA, E SNYDMAN, DR SCHWAITZBERG, SD NASRAWAY, SA GRINDLINGER, J SUMMER, W DEBOISBLANC, B WAHL, M ALESTIG, K GROSSMAN, J MAKI, D PAZ, HL WEINER, M BIHARI, D CAMPBELL, D BLEICHNER, G DAHN, MS LANGE, MPA HALL, J POHLMAN, A WENZEL, RP GROSSERODE, M COSTIGAN, M MILESKI, W WEIGELT, J YESTON, N IRIZARRY, C ROSS, J ROBBINS, J NIGHTINGALE, P OWEN, K SANDSTEDT, S BERG, S SIMON, GL SENEFF, MG CONRY, KM ZIMMERMAN, JL DELLINGER, RP JOHNSTON, R ALLEE, P GRANDE, PO MYHRE, E DHAINAUT, JF HAMY, I MIRA, JP HARMON, J WHITE, J MCKIE, L SILVERMAN, H TUMA, P BENNETT, D PORTER, JC LAURELL, MH JACOBS, S ASH, S STILES, DM PRIOR, MJ KNATTERUD, G TERRIN, M KUFERA, J WILKENS, P RA, K MONROE, L SPRUNG, C HAMILTON, CM MATTHAY, R MCCABE, W TONASCIA, J WIEDEMAN, H WITTES, J CAMPION, GV CROFT, CR LUSTICK, R LOOKABAUGH, J GORDON, GS NOE, L BLOEDOW, D SMITH, CG BRANNON, D KUSH, R NG, D MOORE, E BAZEMORE, K GALVAN, M WAGNER, D HARRELL, F STABLEIN, D TI RECOMBINANT HUMAN INTERLEUKIN-1 RECEPTOR ANTAGONIST IN THE TREATMENT OF PATIENTS WITH SEPSIS SYNDROME - RESULTS FROM A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Article ID TUMOR-NECROSIS-FACTOR; SEPTIC SHOCK; SUBLETHAL ENDOTOXEMIA; MONOCLONAL-ANTIBODY; IL-1 RECEPTOR; MORTALITY; CACHECTIN; RABBITS; PATHOGENESIS; BACTEREMIA AB Objective.-To further define the safety and efficacy of recombinant human interleukin 1 receptor antagonist (rhlL-1ra) in the treatment of sepsis syndrome. Study Design.-Randomized, double-blind, placebo-controlled, multicenter, multinational clinical trial. Population.-A total of 893 patients with sepsis syndrome received an intravenous loading dose of rhIL-1ra, 100 mg, or placebo followed by a continuous 72-hour intravenous infusion of rhIL-1ra (1.0 or 2.0 mg/kg per hour) or placebo. Outcome Measure.-Twenty-eight-day all-cause mortality. Results.-There was not a significant increase in survival time for rhIL-1ra treatment compared with placebo among all patients who received the study medication (n=893; generalized Wilcoxon statistic, P=.22) or among patients with shock at study entry (n=713; generalized Wilcoxon statistic, P=.23), the two primary efficacy analyses specified a priori for this trial. Results from secondary analyses suggest an increase in survival time with rhIL-1ra treatment among patients with dysfunction of one or more organs (n=563; linear dose-response, P=.009). Retrospective analysis demonstrated an increase In survival time with rhIL-1ra treatment among patients with a predicted risk of mortality of 24% or greater (n=580; linear dose-response, P=.005) as well as among patients with both dysfunction of one or more organs and a predicted risk of mortality of 24% or greater (n=411; linear dose-response, P=.002). Conclusions.-There was not a statistically significant increase in survival time for rhIL-1ra treatment compared with placebo among all patients who received the study medication or among patients with shock at study entry. Secondary and retrospective analyses of efficacy suggest that treatment with rhIL-1ra results in a dose-related increase in survival time among patients with sepsis who have organ dysfunction and/or a predicted risk of mortality of 24% or greater. C1 UNIV PARIS 05,COCHIN PORT ROYAL HOSP,DEPT INTENS CARE MED,PARIS,FRANCE. BROWN UNIV,SCH MED,DEPT MED,PROVIDENCE,RI 02912. SYNERGEN INC,DEPT CLIN RES,BOULDER,CO. RUSH PRESBYTERIAN ST LUKES MED CTR,DEPT MED,CHICAGO,IL 60612. UNIV MED & DENT NEW JERSEY,COOPER HOSP,DEPT SURG,CAMDEN,NJ 08103. MT SINAI MED CTR,DEPT SURG,NEW YORK,NY 10029. ST VINCENTS HOSP & MED CTR,DEPT MED,NEW YORK,NY 10011. ST LOUIS UNIV,MED CTR,DEPT SURG,ST LOUIS,MO 63110. VET AFFAIRS MED CTR,DEPT MED,MIAMI,FL. UNIV MIAMI,SCH MED,MIAMI,FL. VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,DEPT SURG,RICHMOND,VA 23298. UNIV S MANCHESTER HOSP,INTENS CARE UNIT,MANCHESTER,LANCS,ENGLAND. MARYLAND MED RES INST,BALTIMORE,MD. GEORGE WASHINGTON UNIV,MED CTR,INTENS CARE RES UNIT,WASHINGTON,DC 20037. USA,WALTER REED ARMY INST RES,DIV COMMUN DIS & IMMUNOL,WASHINGTON,DC. ST LOUIS HLTH SCI CTR,ST LOUIS,MO. VET AFFAIRS MED CTR,BAY PINES,FL. UNIV S FLORIDA,TAMPA,FL. TORONTO GEN HOSP,TORONTO,ON,CANADA. UNIV NEW MEXICO,MED CTR,ALBUQUERQUE,NM 87131. VET AFFAIRS MED CTR,BOISE,ID. ST LUKES REG MED CTR,BOISE,ID. ST ALPHONSUS REG MED CTR,BOISE,ID. UNIV ERLANGEN NURNBERG,CHIRURG KLIN,W-8520 ERLANGEN,GERMANY. CALIF STATE UNIV SACRAMENTO,DAVIS MED CTR,SACRAMENTO,CA. UNIV CINCINNATI,MED CTR,CINCINNATI,OH 45267. MASSACHUSETTS GEN HOSP,BOSTON,MA. CAROLINAS MED CTR,CHARLOTTE,NC. JOHN RADCLIFFE HOSP,OXFORD,ENGLAND. CRIT CARE ASSOCIATES,DES MOINES,IA. ZENT KRANKENHAUS LINKS WESER,BREMEN,GERMANY. PENN STATE UNIV,MILTON S HERSHEY MED CTR,HERSHEY,PA 17033. FREE UNIV BRUSSELS,HOP ERASME,B-1070 BRUSSELS,BELGIUM. UNIV SO ALABAMA,MED CTR,MOBILE,AL. UNIV KENTUCKY,ALBERT B CHANDLER MED CTR,LEXINGTON,KY 40536. DUKE UNIV,MED CTR,DURHAM,NC. UNIV LUBECK,LUBECK,GERMANY. WINTHROP UNIV HOSP,MINEOLA,NY. FREE UNIV AMSTERDAM HOSP,AMSTERDAM,NETHERLANDS. WAYNE STATE UNIV,HARPER HOSP,DETROIT,MI. VANDERBILT UNIV,SCH MED,NASHVILLE,TN 37212. UNIV MINNESOTA,SCH MED,MINNEAPOLIS,MN. VET AFFAIRS MED CTR,BRONX,NY. VICTORIA HOSP,LONDON,ON,CANADA. ST PAULS HOSP,VANCOUVER,BC,CANADA. HOP CALMETTE,LILLE,FRANCE. HOP LOUISE MICHEL,EVRY,FRANCE. CORNELL UNIV,MED CTR,NEW YORK,NY 10021. TUFTS UNIV NEW ENGLAND MED CTR,BOSTON,MA. LOUISIANA STATE UNIV,MED CTR,NEW ORLEANS,LA. GOTHENBURG UNIV,GOTHENBURG,SWEDEN. UNIV WISCONSIN,SCH MED,MADISON,WI. HAHNEMANN UNIV,PHILADELPHIA,PA. GUYS HOSP,LONDON,ENGLAND. CTR HOSP ARGENTEUIL,ARGENTEUIL,FRANCE. UNIV DETROIT,CTR HLTH,DETROIT,MI. UNIV CHICAGO,CHICAGO,IL. UNIV IOWA HOSP & CLIN,IOWA CITY,IA. UNIV TEXAS,SW MED CTR,DALLAS,TX. UNIV CONNECTICUT,HARTFORD HOSP,MED CTR,HARTFORD,CT. LINKOPING UNIV HOSP,LINKOPING,SWEDEN. BAYLOR COLL MED,HOUSTON,TX. UNIV LUND HOSP,LUND,SWEDEN. VET AFFAIRS MED CTR,WASHINGTON,DC. HOP COCHIN,PARIS,FRANCE. UNIV MARYLAND HOSP,BALTIMORE,MD. ST GEORGE HOSP,LONDON,ENGLAND. MALMO GEN HOSP,MALMO,SWEDEN. UNIV WALES HOSP,CARDIFF,WALES. EALING GEN HOSP,SOUTHALL,MIDDX,ENGLAND. APACHE MED SYST INC,WASHINGTON,DC. RP FISHER, CJ (reprint author), CLEVELAND CLIN FDN,DEPT PULM & CRIT CARE MED,CRIT CARE RES UNIT,9500 EUCLID AVE,CLEVELAND,OH 44195, USA. RI Porter, Joanna/C-7162-2009; Friedman, Gilberto/F-7212-2015; Friedman, Gilberto/F-7208-2015 OI Porter, Joanna/0000-0002-7307-169X; NR 37 TC 692 Z9 705 U1 1 U2 17 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD JUN 15 PY 1994 VL 271 IS 23 BP 1836 EP 1843 DI 10.1001/jama.271.23.1836 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA NP959 UT WOS:A1994NP95900027 PM 8196140 ER PT J AU GUTHRIE, JA ANDERSON, WR KOTLAR, AJ HUANG, YH HALPERN, JB AF GUTHRIE, JA ANDERSON, WR KOTLAR, AJ HUANG, YH HALPERN, JB TI STRONG RESONANCE ENHANCEMENT OF THE CN-2-PHOTON ABSORPTION B-2-SIGMA(+)[-X(2)SIGMA(+)(3,0) BY THE A(2)PI(I), V'=4 LEVEL SO JOURNAL OF CHEMICAL PHYSICS LA English DT Article ID DIATOMIC-MOLECULES; MULTIPHOTON TRANSITIONS; 2-PHOTON TRANSITIONS; SPECTROSCOPY; SYSTEM; STATE; PERTURBATIONS; POPULATION; EXCITATION; ALIGNMENT AB We have observed a strong two-photon absorption in the B (2) Sigma(+)<--X (2) Sigma(+)(3,0) band of CN by means of a resonant enhancement through the A (2) Pi(i), v'=4 level. Many lines are seen in the two-photon spectrum due to multiple single-photon near resonances in the A (2) Pi(i)<--X (2) Sigma(+)(4,0) band. The detuning of the laser from these resonances varies from less than one to hundreds of wave numbers, producing unusually large intensity variations in the two-photon spectrum. This effect is not observed in two-photon transitions far from resonance. Resonant enhancement is observed over a range from N=5 to 20. We know of no other molecular two-photon transition in which a near resonance produces such dramatically varying intensities over a short range of rotational levels. A calculation of the line strengths for these transitions reproduces the major features of the spectrum. C1 HOWARD UNIV,CTR STUDY TERR & EXTRATERR ATMOSPHERE,WASHINGTON,DC 20059. RP GUTHRIE, JA (reprint author), USA,RES LAB,ABERDEEN PROVING GROUND,MD 21005, USA. NR 27 TC 0 Z9 0 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-9606 J9 J CHEM PHYS JI J. Chem. Phys. PD JUN 15 PY 1994 VL 100 IS 12 BP 8713 EP 8719 DI 10.1063/1.467259 PG 7 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA NR284 UT WOS:A1994NR28400017 ER PT J AU BURGESS, EB AF BURGESS, EB TI STORMING HEAVEN - BROWN,D SO LIBRARY JOURNAL LA English DT Book Review RP BURGESS, EB (reprint author), USA,TRALINET CTR,FT MONROE,VA, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 SN 0363-0277 J9 LIBR J JI Libr. J. PD JUN 15 PY 1994 VL 119 IS 11 BP 92 EP 92 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA NR058 UT WOS:A1994NR05800189 ER PT J AU BRYANT, GW AF BRYANT, GW TI HUBBARD-MODEL FOR INTERMEDIATE-DIMENSIONAL EXCITONS SO PHYSICAL REVIEW B LA English DT Article ID SEMICONDUCTOR QUANTUM DOTS; CONFINED EXCITON; WANNIER EXCITON; MICROCRYSTALS; WELLS; DYNAMICS; CLUSTERS; SPECTRUM; STATES AB A Hubbard model is solved exactly to characterize confined, intermediate-dimensional excitons for the full range of electron and hole bopping and interaction strengths. Finite systems with periodic boundary conditions model unconfined excitons. Finite systems with terminated ends model confined excitons. Exciton energies, oscillator strengths, and electron and hole distributions are determined. Oscillator strengths and electron-hole distributions of confined intermediate-dimensional excitons exhibit anomalous, nonmonotonic, nonuniversal dependences on the electron-hole interaction strength and hopping that are counter to the conventional behavior for quantum-confined excitons and free excitons. Perturbation theory is used to clarify the weak and large interaction limits. In the large-interaction limit, an exciton dead layer occurs near the boundary of the system because electron-hole correlation is suppressed near the boundary. Second-order perturbation theory determines the surface potential barrier caused by the suppression of pair correlation near the surface and determines the hopping rate for tunneling into this barrier. In the weak-interaction limit, on-site correlation of a confined electron-hole pair is suppressed by asymmetry in the electron and hole hopping. For large asymmetry in the electron and hole hopping, the oscillation strength of the confined intermediate-dimensional exciton can be less than the oscillator strength of an uncorrelated, noninteracting pair. RP BRYANT, GW (reprint author), USA,RES LAB,OPT PROC BRANCH,ADELPHI,MD 20783, USA. NR 31 TC 5 Z9 5 U1 0 U2 1 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0163-1829 J9 PHYS REV B JI Phys. Rev. B PD JUN 15 PY 1994 VL 49 IS 23 BP 16129 EP 16140 DI 10.1103/PhysRevB.49.16129 PG 12 WC Physics, Condensed Matter SC Physics GA NT525 UT WOS:A1994NT52500003 ER PT J AU DUNCAN, WE STOTT, DM BURMAN, KD CHANGE, AS AF DUNCAN, WE STOTT, DM BURMAN, KD CHANGE, AS TI BONE DENSITOMETRY - PRECISION ERROR IS LOW SO BRITISH MEDICAL JOURNAL LA English DT Letter C1 WALTER REED ARMY MED CTR,DEPT MED,KYLE METAB UNIT,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. RP DUNCAN, WE (reprint author), WALTER REED ARMY MED CTR,DEPT MED,ENDOCRINE METAB SERV,WASHINGTON,DC 20307, USA. NR 3 TC 0 Z9 0 U1 0 U2 0 PU BRITISH MED JOURNAL PUBL GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON, ENGLAND WC1H 9JR SN 0959-8138 J9 BRIT MED J JI Br. Med. J. PD JUN 11 PY 1994 VL 308 IS 6943 BP 1567 EP 1567 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA NR110 UT WOS:A1994NR11000049 PM 8019325 ER PT J AU VANDERGRACHT, J AF VANDERGRACHT, J TI SIMULATION OF PARTIALLY COHERENT IMAGING BY OUTER-PRODUCT EXPANSION SO APPLIED OPTICS LA English DT Article ID IMAGERY AB A method for the numerical simulation of partially coherent imaging systems is introduced. The two-dimensional source and pupil functions are decomposed into outer-product sums by the singular value decomposition algorithm, thus reducing the computation of the corresponding nonlinear transform function. The method is computationally efficient when the source and pupil matrices are of sufficiently low rank. Numerical examples are studied and compared with theoretical results. RP VANDERGRACHT, J (reprint author), USA, RES LAB, 2800 POWDER MILL RD, ADELPHI, MD 20783 USA. NR 21 TC 5 Z9 5 U1 0 U2 0 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 0003-6935 J9 APPL OPTICS JI Appl. Optics PD JUN 10 PY 1994 VL 33 IS 17 BP 3725 EP 3731 PG 7 WC Optics SC Optics GA NU497 UT WOS:A1994NU49700014 PM 20885764 ER PT J AU MAHALANOBIS, A KUMAR, BVKV SONG, S SIMS, SRF EPPERSON, JF AF MAHALANOBIS, A KUMAR, BVKV SONG, S SIMS, SRF EPPERSON, JF TI UNCONSTRAINED CORRELATION FILTERS SO APPLIED OPTICS LA English DT Article ID SYNTHETIC DISCRIMINANT FUNCTIONS; CORRELATION-ENERGY FILTERS; PATTERN-RECOGNITION; VARIANCE; NOISE AB A mathematical analysis of the distortion tolerance in correlation filters is presented. A good measure for distortion performance is shown to be a generalization of the minimum average correlation energy criterion. To optimize the filter's performance, we remove the usual hard constraints on the outputs in the synthetic discriminant function formulation. The resulting filters exhibit superior distortion tolerance while retaining the attractive features of their predecessors such as the minimum average correlation energy filter and the minimum variance synthetic discriminant function filter. The proposed theory also unifies several existing approaches and examines the relationship between different formulations. The proposed filter design algorithm requires only simple statistical parameters and the inversion of diagonal matrices, which makes it attractive from a computational standpoint. Several properties of these filters are discussed with illustrative examples. C1 CARNEGIE MELLON UNIV, DEPT ELECT & COMP ENGN, PITTSBURGH, PA 15213 USA. UNIV CALIF SANTA BARBARA, DEPT ELECT & COMP ENGN, SANTA BARBARA, CA 93107 USA. USA, MISSILE COMMAND, CTR RES DEV & ENGN, REDSTONE ARSENAL, AL 35898 USA. UNIV ALABAMA, DEPT MATH SCI, HUNTSVILLE, AL 35898 USA. RP MAHALANOBIS, A (reprint author), HUGHES MISSILE SYST CO, POB 11337, BLDG 802, MAIL STOP 2, TUCSON, AZ 85734 USA. NR 18 TC 247 Z9 256 U1 0 U2 2 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 0003-6935 J9 APPL OPTICS JI Appl. Optics PD JUN 10 PY 1994 VL 33 IS 17 BP 3751 EP 3759 PG 9 WC Optics SC Optics GA NU497 UT WOS:A1994NU49700017 PM 20885767 ER PT J AU SOPOK, S AF SOPOK, S TI UTILIZATION OF ION CHROMATOGRAPHY AND STATISTICS TO DETERMINE IMPORTANT ACIDS IN CHROMIUM PLATING AND ELECTROPOLISHING SOLUTIONS SO JOURNAL OF CHROMATOGRAPHY A LA English DT Article; Proceedings Paper CT 6th International Ion Chromatography Symposium CY SEP 12-15, 1993 CL BALTIMORE, MD SP DIONEX CORP, MILLIPORE, WATERS CHROMATOG DIV AB Inadequate monitoring of sulfuric and chromic acids in chromium plating solutions and phosphoric and sulfuric acids in electropolishing solutions is a serious problem for the industry resulting in poor quality products and wasted resources. This is especially true for the narrow tolerances required to chromium plate cannon systems. Current online and offline instrumental analysis methods either do not result in acceptable precision or are time consuming. Two similar methods, which are improvements on existing ion chromatographic methods, are presented here that provides acceptable analysis and monitoring of these acids in this chromium plating process coupled with an extensive statistical evaluation of the experimental data. For chromium plating solutions, the resultant means and precisions are 2.50 +/- 0.11 g/l sulfuric acid and 250 +/- 5 g/l chromic acid. For electropolishing solutions, these values are 685 +/- 4 g/l phosphoric acid and 845 +/- 5 g/l sulfuric acid. RP SOPOK, S (reprint author), USA,BENET LABS,WATERVLIET,NY 12189, USA. NR 12 TC 2 Z9 2 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0021-9673 J9 J CHROMATOGR A JI J. Chromatogr. A PD JUN 10 PY 1994 VL 671 IS 1-2 BP 265 EP 271 DI 10.1016/0021-9673(94)80249-1 PG 7 WC Biochemical Research Methods; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA NT177 UT WOS:A1994NT17700038 ER PT J AU ADAMS, GF CHABALOWSKI, CF AF ADAMS, GF CHABALOWSKI, CF TI QUANTUM-CHEMICAL STUDY OF THE POTENTIAL-ENERGY CURVES AND ELECTRONIC-TRANSITION STRENGTHS IN HCL, XECL, AND HCL+XE SO JOURNAL OF PHYSICAL CHEMISTRY LA English DT Article ID INTER-STELLAR CLOUDS; NOBLE-GAS HALIDES; CHARGE-TRANSFER; SOLID XENON; HYDROGEN-CHLORIDE; RADIATIVE DISSOCIATION; INTERSTELLAR CLOUDS; PHOTO-DISSOCIATION; GAIN MEASUREMENTS; CI CALCULATIONS AB Potential energy curves and electronic transition strengths are calculated for selected singlet states in HCl, XeCl, and HCl + Xe using effective core potentials (ECPs) with state-averaged CASSCF-CI techniques. In HCl, the maximum photoabsorption cross section for the ($) over tilde A((1) Pi) <-- ($) over tilde X((1) Sigma(+)) transition is calculated to be sigma(v'') 3.86 X 10(-18) cm(2) for the v'' = 0 band, in good agreement with the experimental value of sigma(v'') = 3.8 X 10(-18) cm(2). The oscillator strength for the 0-0 transition in ($) over tilde C((1) Pi) <-- ($) over tilde X((1) Sigma(+)) is calculated to be f(00) = 0.175, differing by 5% from the experimental value of f(00) = 0.185 +/- 0.037. The calculated oscillator strength for excitation into v' = 1 is significantly larger than the experimental values or those from previous theoretical treatments. In the XeCl, radiative lifetimes, tau, are predicted for selected doublet excited electronic states. This study substantiates earlier theoretical predictions and compares favorably with available experimental lifetimes. In the HCl + Xe system, low-lying singlet states are calculated as a function of the HCl-Xe distance with the H-Cl distance held fixed and the atoms kept collinear. A charge-transfer state is located which represents the excitation of a pi electron into a sigma* antibonding orbital. This state offers a simplified model of the photoinitiated charge transfer observed in solid xenon doped with HCl, where the HCl is reported to dissociated after transfer of an electron from Xe to HCl. Other electronic states and electronic transition moments of the HCl + Xe system are analyzed and related to the isolated HCl electronic states and transitions when possible. C1 USA,RES LAB,AMSRL WT PC,ABERDEEN PROVING GROUND,MD 21005. NR 62 TC 14 Z9 14 U1 0 U2 6 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0022-3654 J9 J PHYS CHEM-US JI J. Phys. Chem. PD JUN 9 PY 1994 VL 98 IS 23 BP 5878 EP 5890 DI 10.1021/j100074a011 PG 13 WC Chemistry, Physical SC Chemistry GA NQ725 UT WOS:A1994NQ72500011 ER PT J AU KEWITSCH, AS SEGEV, M YARIV, A SALAMO, GJ TOWE, TW SHARP, EJ NEURGAONKAR, RR AF KEWITSCH, AS SEGEV, M YARIV, A SALAMO, GJ TOWE, TW SHARP, EJ NEURGAONKAR, RR TI TUNABLE QUASI-PHASE MATCHING USING DYNAMIC FERROELECTRIC DOMAIN GRATINGS INDUCED BY PHOTOREFRACTIVE SPACE-CHARGE FIELDS SO APPLIED PHYSICS LETTERS LA English DT Article ID 2ND-HARMONIC GENERATION; VOLUME HOLOGRAMS; WAVE-GUIDE; CRYSTALS; LINBO3; LIGHT AB We demonstrate a method of dynamic, tunable quasi-phase matched second-harmonic generation using optically induced polarization gratings with periods equal to twice the coherence length. These gratings increase the peak second-harmonic conversion efficiency by a factor of 17 above a poled strontium barium niobate crystal, to 0.01% for fundamental beam intensities of 0.8 MW cm-2. We generate quasi-phase matching spectral response peaks as narrow as 0.175 nm and tailor the response by writing an ensemble of gratings in the same volume, each of which enhances the second-harmonic generation at a predetermined wavelength. C1 UNIV ARKANSAS,DEPT PHYS,FAYETTEVILLE,AR 72701. USA,FT BELVOIR,VA 22060. ROCKWELL INT CORP,CTR SCI,THOUSAND OAKS,CA 91360. RP KEWITSCH, AS (reprint author), CALTECH,DEPT APPL PHYS,PASADENA,CA 91125, USA. NR 17 TC 23 Z9 23 U1 0 U2 1 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD JUN 6 PY 1994 VL 64 IS 23 BP 3068 EP 3070 DI 10.1063/1.111349 PG 3 WC Physics, Applied SC Physics GA NP752 UT WOS:A1994NP75200002 ER PT J AU NABET, B PAOLELLA, A COOKE, P LEMUENE, ML MOERKIRK, RP LIOU, LC AF NABET, B PAOLELLA, A COOKE, P LEMUENE, ML MOERKIRK, RP LIOU, LC TI INTERMEDIATE TEMPERATURE MOLECULAR BEAM-EPITAXY GROWTH FOR DESIGN OF LARGE-AREA METAL-SEMICONDUCTOR-METAL PHOTODETECTORS SO APPLIED PHYSICS LETTERS LA English DT Article ID GAAS AB Large-area metal-semiconductor-metal (MSM) photodetectors are fabricated on molecular beam epitaxy (MBE) grown GaAs material at growth temperatures ranging from 250 to 500-degrees-C. it is shown that materials grown at intermediate temperatures are a suitable choice for large-area, high photocurrent detectors. Particularly, MSM devices made from material grown at around 350-degrees-C have a dark current of the same magnitude as those grown at lower temperatures while having a substantially larger photocurrent. Higher low-field mobility at intermediate temperatures should give these devices speed advantage as well. A change of close to 4 orders of magnitude in dark current and more than 2 orders of magnitude in light response is observed for this temperature range. C1 USA,RES LAB,ELECTR & POWER SOURCES DIRECTORATE,FT MONMOUTH,NJ 07703. DREXEL UNIV,DEPT ELECT & COMP ENGN,PHILADELPHIA,PA 19104. RP NABET, B (reprint author), DREXEL UNIV,DEPT ELECT & COMP ENGN,PHILADELPHIA,PA 19104, USA. NR 13 TC 9 Z9 9 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD JUN 6 PY 1994 VL 64 IS 23 BP 3151 EP 3153 DI 10.1063/1.111322 PG 3 WC Physics, Applied SC Physics GA NP752 UT WOS:A1994NP75200030 ER PT J AU FIFER, RA MORRIS, JB AF FIFER, RA MORRIS, JB TI APPROXIMATE TECHNIQUES FOR THE CALCULATION OF HEATS OF EXPLOSION USING THERMOCHEMICAL COMPUTER CODES SO THERMOCHIMICA ACTA LA English DT Article AB Procedures are outlined for calculating the heats of explosion (HEX) of neat energetic materials or propellant/explosive formulations using thermochemical computer codes. The ''exact'' method and three approximate techniques are described; the approximate techniques either eliminate the need to sum the internal energies of the predicted products, or eliminate the need to specify a freeze-out temperature. The various techniques are illustrated for HMX and a nitrocellulose/nitroglycerine (NC/NG) mixture. C1 USA,RES LAB,AMSRL,WT,PC,ABERDEEN PROVING GROUND,MD 21005. NR 14 TC 2 Z9 2 U1 0 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0040-6031 J9 THERMOCHIM ACTA JI Thermochim. Acta PD JUN 6 PY 1994 VL 237 IS 2 BP 375 EP 389 DI 10.1016/0040-6031(94)80195-9 PG 15 WC Thermodynamics; Chemistry, Analytical; Chemistry, Physical SC Thermodynamics; Chemistry GA NW967 UT WOS:A1994NW96700018 ER PT J AU KUSCHNER, RA HEPPNER, DG ANDERSEN, SL WELLDE, BT HALL, T SCHNEIDER, I BALLOU, WR FOULDS, G SADOFF, JC SCHUSTER, B TAYLOR, DN AF KUSCHNER, RA HEPPNER, DG ANDERSEN, SL WELLDE, BT HALL, T SCHNEIDER, I BALLOU, WR FOULDS, G SADOFF, JC SCHUSTER, B TAYLOR, DN TI AZITHROMYCIN PROPHYLAXIS AGAINST A CHLOROQUINE-RESISTANT STRAIN OF PLASMODIUM-FALCIPARUM SO LANCET LA English DT Note ID PHARMACOKINETICS; MEFLOQUINE; SAFETY AB Azithromycin has antimalarial activity and favourable pharmacokinetic properties for a prophylactic antimalarial agent. We investigated the ability of azithromycin to prevent malaria in volunteers infected with a chloroquine-resistant strain of Plasmodium falciparum. 4 volunteers received oral azithromycin 500 mg followed by 250 mg daily for 7 further days. Subjects were infected on the third day of azithromycin. 3 subjects were protected compared with none of 15 controls. The volunteer not protected by azithromycin had unquantifiable plasma levels of azithromycin, probably because of poor absorption. Azithromycin could be a promising prophylactic agent for P falciparum malaria. C1 WALTER REED ARMY INST RES,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307. PFIZER INC,CENT RES,GROTON,CT. RP KUSCHNER, RA (reprint author), WALTER REED ARMY INST RES,DIV COMMUNICABLE DIS & IMMUNOL,WASHINGTON,DC 20307, USA. NR 11 TC 43 Z9 46 U1 0 U2 0 PU LANCET LTD PI LONDON PA 42 BEDFORD SQUARE, LONDON, ENGLAND WC1B 3SL SN 0140-6736 J9 LANCET JI Lancet PD JUN 4 PY 1994 VL 343 IS 8910 BP 1396 EP 1397 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA NP955 UT WOS:A1994NP95500012 PM 7910886 ER PT J AU HINES, HB BRUEGGEMANN, EE AF HINES, HB BRUEGGEMANN, EE TI FACTORS AFFECTING THE CAPILLARY ELECTROPHORESIS OF RICIN, A TOXIC GLYCOPROTEIN SO JOURNAL OF CHROMATOGRAPHY A LA English DT Article ID ZONE ELECTROPHORESIS; FUSED-SILICA; A-CHAIN; ABRUS-PRECATORIUS; PROTEIN-SYNTHESIS; SUGAR CHAINS; B-CHAINS; PURIFICATION; SEPARATIONS; ADSORPTION AB Conditions for the analysis of ricin with capillary electrophoresis were investigated. Uncoated and coated columns were tested with a variety of different buffer combinations which included different principal components, pH, ionic strength, and additives. Of the combinations tested, uncoated columns used with either zwitterionic salts or putrescine gave the best results. Multiple peaks were resolved with these conditions. Coated columns generally yielded between 1000 and 5000 plates with several buffer combinations. Ricin may be analyzed faster and with greater resolution with capillary electrophoresis employing untreated fused-silica columns than by using other chromatographic techniques. RP HINES, HB (reprint author), USA,MED RES INST INFECT DIS,DIV TOXICOL,FT DETRICK,MD 21702, USA. NR 41 TC 14 Z9 15 U1 1 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0021-9673 J9 J CHROMATOGR A JI J. Chromatogr. A PD JUN 3 PY 1994 VL 670 IS 1-2 BP 199 EP 208 DI 10.1016/0021-9673(94)80295-5 PG 10 WC Biochemical Research Methods; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA NR679 UT WOS:A1994NR67900021 ER PT J AU VANKEKEN, PE YUEN, DA VANDENBERG, AP AF VANKEKEN, PE YUEN, DA VANDENBERG, AP TI IMPLICATIONS FOR MANTLE DYNAMICS FROM THE HIGH-MELTING TEMPERATURE OF PEROVSKITE SO SCIENCE LA English DT Article ID NEWTONIAN RHEOLOGY; CONVECTION; VISCOSITY; PRESSURE; FLOW AB Recent studies have implied that (Mg,Fe)SiO3-perovskite, a likely dominant mineral phase in the lower mantle, may have a high melting temperature. The implications of these findings for the dynamics of the lower mantle were investigated with the use of numerical convection models. The results showed that low homologous temperatures (0.3 to 0.5) would prevail in the modeled lower mantle, regardless of the effective Rayleigh number and internal heating rates. High-temperature ductile creep is possible under relatively cold conditions. In models with low rates of internal heating, local maxima of viscosity developed in the mid-lower mantle that were similar to those obtained from inversion of geoid, topography, and plate velocities. C1 UNIV MINNESOTA,MINNESOTA SUPERCOMP INST,MINNEAPOLIS,MN 55415. INST EARTH SCI,DEPT THEORET GEOPHYS,3508 TA UTRECHT,NETHERLANDS. RP VANKEKEN, PE (reprint author), UNIV MINNESOTA,ARMY HIGH PERFORMANCE COMP RES CTR,1100 WASHINGTON AVE S,MINNEAPOLIS,MN 55415, USA. NR 23 TC 35 Z9 35 U1 0 U2 2 PU AMER ASSOC ADVANCEMENT SCIENCE PI WASHINGTON PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 SN 0036-8075 J9 SCIENCE JI Science PD JUN 3 PY 1994 VL 264 IS 5164 BP 1437 EP 1439 DI 10.1126/science.264.5164.1437 PG 3 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA NP221 UT WOS:A1994NP22100035 PM 17838427 ER PT J AU LOOAREESUWAN, S VANIJANONTA, S VIRAVAN, C WILAIRATANA, P CHAROENLARP, P LASSERRE, R CANFIELD, C KYLE, DE WEBSTER, HK AF LOOAREESUWAN, S VANIJANONTA, S VIRAVAN, C WILAIRATANA, P CHAROENLARP, P LASSERRE, R CANFIELD, C KYLE, DE WEBSTER, HK TI RANDOMIZED TRIAL OF MEFLOQUINE-TETRACYCLINE AND QUININE-TETRACYCLINE FOR ACUTE UNCOMPLICATED FALCIPARUM-MALARIA SO ACTA TROPICA LA English DT Article DE MALARIA; PLASMODIUM FALCIPARUM; CHEMOTHERAPY; MEFLOQUINE PLUS TETRACYCLINE; QUININE PLUS TETRACYCLINE ID PLASMODIUM-FALCIPARUM; THAILAND; PYRIMETHAMINE; COMBINATION; SULFADOXINE; RESISTANT AB The combination of mefloquine plus tetracycline was compared with quinine plus tetracycline in a randomised therapeutic trial in 102 patients with acute uncomplicated falciparum malaria in Thailand. Quinine plus tetracycline is considered the standard treatment for the highly drug-resistant strains of P. falciparum found in this area. Fifty patients received mefloquine (750 mg given immediately, followed by 500 mg 6 h later) with tetracycline and 52 patients received quinine (600 mg every 8 h for seven days) with tetracycline. Tetracycline was administered to both groups in doses of 250 mg four times daily. All patients were admitted to the hospital for 28 days to exclude re-infection. Ninety-three patients completed the study; nine patients left prior to completion of follow-up for reasons unrelated to their treatment. Cure rates for the two groups were 94% (44/47) for mefloquine plus tetracycline and 98% (45/46) for quinine plus tetracycline. Parasite and fever clearance times were shorter for the group treated with mefloquine but the differences were not statistically significant. Nearly all patients (94%) treated with quinine developed cinchonism compared with only 12% treated with mefloquine; all other symptoms following treatment were similar. Thirteen patients (26%) treated with quinine also developed delayed primary attacks of P. vivax during the follow-up period; none developed in the patients treated with mefloquine. These results support the contention that the combination of mefloquine plus tetracycline is equally effective and less toxic than quinine plus tetracycline for treatment of acute uncomplicated falciparum malaria in areas requiring combination therapy for drug resistance. C1 MAHIDOL UNIV,BANGKOK HOSP TROP DIS,FAC TROP MED,BANGKOK 10400,THAILAND. ROCHE ASIAN RES FDN,HONG KONG,HONG KONG. PHARMACEUT SYST INC,GAITHERSBURG,MD. USA,MED COMPONENT,ARMED FORCES RES INST MED SCI,DEPT IMMUNOL & PARASITOL,BANGKOK 10400,THAILAND. RP LOOAREESUWAN, S (reprint author), MAHIDOL UNIV,FAC TROP MED,DEPT CLIN TROP MED,420-6 RAJVITHI RD,BANGKOK 10400,THAILAND. NR 16 TC 26 Z9 28 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0001-706X J9 ACTA TROP JI Acta Trop. PD JUN PY 1994 VL 57 IS 1 BP 47 EP 53 DI 10.1016/0001-706X(94)90092-2 PG 7 WC Parasitology; Tropical Medicine SC Parasitology; Tropical Medicine GA NX074 UT WOS:A1994NX07400006 PM 7942354 ER PT J AU BLUMSTEIN, RB RATTO, JA AF BLUMSTEIN, RB RATTO, JA TI PERMEATION PROPERTIES OF LIQUID-CRYSTAL - POLYMER COMPOSITE MEMBRANES SO ADVANCED MATERIALS LA English DT Article ID PERMSELECTIVE CHARACTERISTICS C1 USA,NATICK RES DEV & ENGN CTR,NATICK,MA 01760. RP BLUMSTEIN, RB (reprint author), UNIV MASSACHUSETTS LOWELL,DEPT CHEM,POLYMER PROGRAM,UNIV AVE,LOWELL,MA, USA. NR 18 TC 2 Z9 2 U1 0 U2 2 PU VCH PUBLISHERS INC PI DEERFIELD BEACH PA 303 NW 12TH AVE, DEERFIELD BEACH, FL 33442-1788 SN 0935-9648 J9 ADV MATER JI Adv. Mater. PD JUN PY 1994 VL 6 IS 6 BP 503 EP 506 DI 10.1002/adma.19940060616 PG 4 WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Chemistry; Science & Technology - Other Topics; Materials Science; Physics GA NR585 UT WOS:A1994NR58500015 ER PT J AU VLACHOS, DG SCHMIDT, LD ARIS, R AF VLACHOS, DG SCHMIDT, LD ARIS, R TI IGNITION AND EXTINCTION OF FLAMES NEAR SURFACES - COMBUSTION OF CH4 IN AIR SO AICHE JOURNAL LA English DT Article ID STAGNATION-POINT FLOW; MASS-TRANSFER; GAS-PHASE; METHANE; ETHANE; H-2 AB Ignition and extinction characteristics of homogeneous combustion of methane in air near inert surfaces are studied by numerical bifurcation theory for premixed methane/air gases impinging on planar surfaces with detailed chemistry involving 46 reversible reactions and 16 species. One-parameter bifurcation diagrams as functions of surface temperature and two-parameter bifurcation diagrams as functions of equivalence ratio and strain rate are constructed for both isothermal and adiabatic walls. Lean and rich composition limits for ignition and extinction, and energy production are determined from two parameter bifurcation diagrams. For a strain rate of 500 s-1, CH4/air mixtures exhibit hysteresis from approximately 0.5% up to approximately 12.5% and from approximately 5.5% up to approximately 13.5% near isothermal surfaces and adiabatic walls, respectively. Ignition temperature rises with composition from 1,700 to 1,950 K, without a maximum around the stoichiometric ratio. Under some conditions multiple ignitions and extinctions can occur with up to five multiple solutions, and wall quenching, kinetic limitations, and transport can strongly affect flame stability. Flames near the stoichiometric ratio cannot be extinguished by room temperature surfaces for sufficiently low strain rates. The role of intermediates in enhancing or retarding ignition and extinction is studied, and implications of the effect of catalytic surfaces on homogeneous ignition and extinction are discussed. Removal of H atoms and CH3 radicals by wall adsorption can increase extinction and ignition temperature of 6% CH4 in air by up to 300 K for a strain rate of 500 s-1. C1 UNIV MINNESOTA,DEPT CHEM ENGN & MAT SCI,MINNEAPOLIS,MN 55455. UNIV MINNESOTA,ARMY HIGH PERFORMANCE COMP RES CTR,MINNEAPOLIS,MN 55455. OI Vlachos, Dionisios/0000-0002-6795-8403 NR 39 TC 55 Z9 55 U1 1 U2 7 PU AMER INST CHEMICAL ENGINEERS PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 SN 0001-1541 J9 AICHE J JI AICHE J. PD JUN PY 1994 VL 40 IS 6 BP 1005 EP 1017 DI 10.1002/aic.690400611 PG 13 WC Engineering, Chemical SC Engineering GA NR148 UT WOS:A1994NR14800011 ER PT J AU VLACHOS, DG SCHMIDT, LD ARIS, R AF VLACHOS, DG SCHMIDT, LD ARIS, R TI PRODUCTS IN METHANE COMBUSTION NEAR SURFACES SO AICHE JOURNAL LA English DT Article ID FLAMES; WALL; EXTINCTION; AIR AB Emission of carbon monoxide (CO), formaldehyde (CH2O), and unburned methane (CH4) are calculated for premixed methane/air mixtures impinging on a flat surface as functions of surface temperature, equivalence ratio, and strain rate with detailed chemistry involving 46 reversible reactions and 16 species using numerical bifurcation theory. Multiple solutions with different selectivities to stable products are found. On the extinguished branch unburned CH4, molecular hydrogen (H-2), CO, and CH2O dominate, whereas on the ignited branch carbon dioxide (CO2) predominates near the surface. Cold walls can promote the selectivity to CO and CH2O near extinction, and high flow rates can increase considerably the formation of CO, CH2O, and unburned CH4. For example, an ignited stoichiometric methane/air mixture (9.5% CH4 in air) impinging on a surface of 1,000 K is calculated to produce 2 % CO, 150 ppm CH2O, and 3 % unburned CH4 for a strain rate of 500 s-1. Maximum efficiency of CH4 and minimum selectivity to CH2O occur near the stoichiometric ratio, whereas minimum selectivity to CO occurs for fuel lean mixtures. Comparison of combustion near surfaces with freely propagating flames is also shown. C1 UNIV MINNESOTA,DEPT CHEM ENGN & MAT SCI,MINNEAPOLIS,MN 55455. UNIV MINNESOTA,ARMY HIGH PERFORMANCE COMP RES CTR,MINNEAPOLIS,MN 55455. OI Vlachos, Dionisios/0000-0002-6795-8403 NR 16 TC 14 Z9 15 U1 1 U2 6 PU AMER INST CHEMICAL ENGINEERS PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 SN 0001-1541 J9 AICHE J JI AICHE J. PD JUN PY 1994 VL 40 IS 6 BP 1018 EP 1025 DI 10.1002/aic.690400612 PG 8 WC Engineering, Chemical SC Engineering GA NR148 UT WOS:A1994NR14800012 ER PT J AU WINSLOW, DL MAYERS, D SCARNATI, H LANE, J BINCSIK, A OTTO, MJ AF WINSLOW, DL MAYERS, D SCARNATI, H LANE, J BINCSIK, A OTTO, MJ TI IN-VITRO SUSCEPTIBILITY OF CLINICAL ISOLATES OF HIV-1 TO XM323, A NON-PEPTIDYL HIV PROTEASE INHIBITOR SO AIDS LA English DT Note DE HIV PROTEASE INHIBITORS; RESISTANCE; ANTIRETROVIRAL AGENTS; NUCLEOSIDE ANALOGS; HIV-1 CLINICAL ISOLATES ID HUMAN-IMMUNODEFICIENCY-VIRUS; REDUCED SENSITIVITY; ANALOG INHIBITORS; RATIONAL DESIGN; ZIDOVUDINE AZT; MATURATION; INVITRO AB Objective: To determine the in vitro susceptibility of primary clinical isolates and laboratory strains of HIV-7 to XM323. Methods: The AIDS Clinical Trials Group/US Department of Defense p24 antigen-based consensus assay was used to determine in vitro susceptibility of 57 primary clinical isolates and three laboratory strains of HIV-1 to XM323, zidovudine, zalcitabine (ddC), and didanosine (ddl). Results: The concentrations of compound required to inhibit viral p24 antigen production by 50% [median inhibitory concentration (IC50)] for nucleosides were as follows: zidovudine, 0.001-> 5 mu M; ddC, < 0.01-0.23 mu M; ddl, 0.2-> 25 mu M). Against both nucleoside susceptible and resistant isolates XM323 exhibited potent inhibition with IC50 values of <0.02-0.27 mu M and IC90 values of 0.03-1.17 mu M. Conclusions: XM323 is a potent inhibitor of diverse clinical isolates of HIV-1 in vitro and represents a novel class of non-peptidyl inhibitors of HIV-1 protease. C1 DUPONT MERCK PHARMACEUT CO,GLENOLDEN,PA. WALTER REED ARMY INST RES,ROCKVILLE,MD. SRA TECHNOL INC,ROCKVILLE,MD. MED CTR DELAWARE,WILMINGTON,DE. NR 26 TC 7 Z9 7 U1 0 U2 0 PU RAPID SCIENCE PUBLISHERS PI LONDON PA 2-6 BOUNDARY ROW, LONDON, ENGLAND SE1 8NH SN 0269-9370 J9 AIDS JI Aids PD JUN PY 1994 VL 8 IS 6 BP 753 EP 756 DI 10.1097/00002030-199406000-00005 PG 4 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA NP436 UT WOS:A1994NP43600005 PM 8086132 ER PT J AU VAHEY, M BIRX, DL MICHEAL, NL BURKE, DS REDFIELD, RR AF VAHEY, M BIRX, DL MICHEAL, NL BURKE, DS REDFIELD, RR TI ASSESSMENT OF GAG DNA AND GENOMIC RNA IN PERIPHERAL-BLOOD MONONUCLEAR-CELLS IN HIV-INFECTED PATIENTS RECEIVING INTERVENTION WITH A RECOMBINANT GP160 SUBUNIT VACCINE IN A PHASE-I STUDY SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Article ID IMMUNODEFICIENCY-VIRUS TYPE-1; EXPRESSION; DISEASE; STAGE; VIREMIA; PLASMA RP VAHEY, M (reprint author), WALTER REED ARMY MED CTR,INST RES,DIV RETROVIROL,13 TAFT COURT,1600 E GUIDE DR,ROCKVILLE,MD 20850, USA. OI /0000-0002-5704-8094 NR 14 TC 8 Z9 8 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD JUN PY 1994 VL 10 IS 6 BP 649 EP 654 DI 10.1089/aid.1994.10.649 PG 6 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA NU496 UT WOS:A1994NU49600004 PM 8074929 ER PT J AU STERLING, KB AF STERLING, KB TI SCIENCE IN THE SUB-ARCTIC - TRAPPERS, TRADERS, AND THE SMITHSONIAN-INSTITITION - LINDSAY,D SO AMERICAN HISTORICAL REVIEW LA English DT Book Review RP STERLING, KB (reprint author), USA,ORDNANCE CTR & SCH,WASHINGTON,DC 20310, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU AMER HISTORICAL REVIEW PI WASHINGTON PA 400 A ST SE, WASHINGTON, DC 20003 SN 0002-8762 J9 AM HIST REV JI Am. Hist. Rev. PD JUN PY 1994 VL 99 IS 3 BP 982 EP 983 DI 10.2307/2167933 PG 2 WC History SC History GA NT912 UT WOS:A1994NT91200167 ER PT J AU HILL, RB ADAMS, S GUNN, BA EBERLY, BJ AF HILL, RB ADAMS, S GUNN, BA EBERLY, BJ TI THE EFFECTS OF NONCLASSIC PEDIATRIC BACTERIAL PATHOGENS ON THE USEFULNESS OF THE DIRECTIGEN LATEX AGGLUTINATION-TEST SO AMERICAN JOURNAL OF CLINICAL PATHOLOGY LA English DT Article DE ANTIGEN DETECTION SYSTEM; BACTERIAL ANTIGEN DETECTION SYSTEM; CEREBROSPINAL FLUID PATHOGENS; DIRECTIGEN; MENINGITIS ID MENINGITIS; DIAGNOSIS; POPULATION AB Haemophilus influenzae type b, Escherichia coli, Neisseria meningitis, Streptococcus agalactiae, and Streptococcus pneumoniae are classically the predominant meningeal pathogens of children. The Directigen(TM) latex agglutination test identifies these pathogens by detecting specific antigens in cerebrospinal fluid (CSF) and urine. The authors tested 1151 specimens from 791 children with suspected meningeal infections. They found that the sensitivity of the Directigen test for detecting the five classic CSF pathogens of children was 83.3% with CSF and 60% with urine specimens. In detecting all pathogens, however, the sensitivity was only 50% with CSP and 37.5% with urine. Thus, an increased prevalence of nonclassic pathogens in a pediatric population adversely affects the efficacy of the Directigen test for confirming a diagnosis of meningitis and emphasizes the diagnostic importance of the clinical history and other routine CSF tests. C1 TRIPLER ARMY MED CTR,AREA LAB SERV,HONOLULU,HI 96859. TEXAS DEPT HLTH,BUR NUTR SERV,AUSTIN,TX. RP HILL, RB (reprint author), TRIPLER ARMY MED CTR,DEPT PATHOL,HONOLULU,HI 96859, USA. NR 19 TC 5 Z9 5 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0002-9173 J9 AM J CLIN PATHOL JI Am. J. Clin. Pathol. PD JUN PY 1994 VL 101 IS 6 BP 729 EP 732 PG 4 WC Pathology SC Pathology GA NQ302 UT WOS:A1994NQ30200012 PM 8209860 ER PT J AU LEVIN, LI CHUNG, RC MILAZZO, M BRUNDAGE, JF AF LEVIN, LI CHUNG, RC MILAZZO, M BRUNDAGE, JF TI HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 (HIV-1) DISEASE PROGRESSION - IS THERE A DIFFERENCE BY GENDER SO AMERICAN JOURNAL OF EPIDEMIOLOGY LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU JOHNS HOPKINS UNIV SCHOOL HYGIENE PUB HEALTH PI BALTIMORE PA 111 MARKET PLACE, STE 840, BALTIMORE, MD 21202-6709 SN 0002-9262 J9 AM J EPIDEMIOL JI Am. J. Epidemiol. PD JUN 1 PY 1994 VL 139 IS 11 SU S BP S29 EP S29 PG 1 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA NP863 UT WOS:A1994NP86300097 ER PT J AU BATY, DL STORIE, DJ VONFRAUNHOFER, JA AF BATY, DL STORIE, DJ VONFRAUNHOFER, JA TI SYNTHETIC ELASTOMERIC CHAINS - A LITERATURE-REVIEW SO AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS LA English DT Review ID DEGRADATION C1 USA,DENTAL CORPS,FT CAMPBELL,KY. RP BATY, DL (reprint author), USA,DENT CORPS,DENTAC,HSBY DE,FT RILEY,KS 66442, USA. NR 27 TC 21 Z9 31 U1 2 U2 3 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0889-5406 J9 AM J ORTHOD DENTOFAC JI Am. J. Orthod. Dentofac. Orthop. PD JUN PY 1994 VL 105 IS 6 BP 536 EP 542 DI 10.1016/S0889-5406(94)70137-7 PG 7 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA NQ776 UT WOS:A1994NQ77600008 PM 8198077 ER PT J AU HURWITZ, KM ROACH, JM ARGYROS, GJ ELIASSON, AH PHILLIPS, YY AF HURWITZ, KM ROACH, JM ARGYROS, GJ ELIASSON, AH PHILLIPS, YY TI REFRACTORY PERIOD DURING PROVOCATION WITH EUCAPNIC HYPERVENTILATION AND METHACHOLINE SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE LA English DT Article ID EXERCISE-INDUCED ASTHMA; RESPIRATORY HEAT-LOSS; VOLUNTARY HYPERVENTILATION; TREADMILL EXERCISE; CHALLENGE; DECREASES AB Eucapnic voluntary hyperventilation (EVH) and methacholine inhalation challenge (MIC) both cause bronchoconstriction in asthmatics. A refractory period, or time when the response to bronchoprovocation in a series of challenges is diminished, has been found after hyperventilation or exercise but not after MIC. We investigated whether EVH or MIC blunted the response to the other test. Sixteen asthmatics were studied on 2 d, taking both tests each day. They were randomized to either EVH or MIV first on Day 1, then the opposite order on Day 2, 6 to 14 d apart. After EVH as a first test, the mean decline in FEV(1) from base-line was 18.66 +/- 4.76% (mean +/- SEM), but when EVH followed MIC, the response to EVH was reduced by 30%, to a decline in FEV(1) of only 13.02 +/- 3.75% (p = 0.0026). During MIC, the mean provocation dose to cause 20% decrease in FEV(1) (PD20) given as the initial challenge was 54.77 +/- 21.60 breath units, compared with 46.94 +/- 19.55 breath units when MIC followed EVH (p = 0.54). However, the subset of patients most sensitive to methacholine (PD20 < 0.1 breath unit) had changes suggestive of a refractory period after EVH, with a mean increase in the PD20 from 0.06 +/- 0.01 to 3.35 +/- 1.43 (p = 0.069). Our data show that MIC attenuates the response to subsequent challenge with EVH. Conversely, EVH may only affect subsequent MIC in those most sensitive to methacholine. C1 UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. RP HURWITZ, KM (reprint author), WALTER REED ARMY MED CTR,DEPT MED,PULM & CRIT CARE MED SERV,WASHINGTON,DC 20307, USA. NR 29 TC 6 Z9 6 U1 0 U2 0 PU AMER LUNG ASSOC PI NEW YORK PA 1740 BROADWAY, NEW YORK, NY 10019 SN 1073-449X J9 AM J RESP CRIT CARE JI Am. J. Respir. Crit. Care Med. PD JUN PY 1994 VL 149 IS 6 BP 1452 EP 1456 PG 5 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA NQ971 UT WOS:A1994NQ97100010 PM 8004298 ER PT J AU WILSON, ML CHAPMAN, LE HALL, DB DYKSTRA, EA BA, K ZELLER, HG TRAORELAMIZANA, M HERVY, JP LINTHICUM, KJ PETERS, CJ AF WILSON, ML CHAPMAN, LE HALL, DB DYKSTRA, EA BA, K ZELLER, HG TRAORELAMIZANA, M HERVY, JP LINTHICUM, KJ PETERS, CJ TI RIFT-VALLEY FEVER IN RURAL NORTHERN SENEGAL - HUMAN RISK-FACTORS AND POTENTIAL VECTORS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID CONGO HEMORRHAGIC-FEVER; DOMESTIC-ANIMALS; SOUTH-AFRICA; HUMAN-SERA; VIRUS; KENYA; ANTIBODIES; OUTBREAK; EPIDEMIOLOGY; TRANSMISSION AB To investigate past infection in and transmission of Rift Valley fever (RVF) virus to humans within an endemic focus, we undertook a retrospective cohort study of the seminomadic Peul people living in sub-Saharan northcentral Senegal. Residents of the rural settlement of Yonofere five years of age or older were studied during February-May 1989. Anti-RVF virus IgG was found in blood samples of 22.3% of 273 persons who responded to a standard questionnaire; none had IgM antibodies. Seropositivity was similar for males (25.4%) and females (21.1%), increased markedly with age for both sexes, and varied considerably among compounds (groups of huts) (0-37.5%). Risk factors for past RVF virus infection were nursing sick people, assisting animals during abortions/births, and treating sick animals. In all age groups, odds ratios (ORs) for RVF viral antibody among females who reported treating sick animals were three to six times greater than for those who did not. The ORs for males who reported assisting with animal births/abortions and nursing sick people were approximately five times those for males who did not. Serologic prevalence of RVF viral antibody among sheep averaged 30.1% overall (0.8% IgM), but varied among compounds (0-66.7%) in a manner different from that of humans. The seasonal abundance and relative density of potential mosquito vectors were estimated by monthly samples captured in Centers for Disease Control and Prevention-type traps. Mosquito abundance varied seasonally with rainfall (> 90% captures during four months). Species diversity was large (28 spp.), dominated by Aedes and Culex. Rift Valley fever virus was not isolated from 142 pools of 2,956 unengorged mosquitoes tested, although three other arboviruses were found. Results indicate that RVF is endemic in this region, people are at considerable risk of infection, and that a heretofore unrecognized mode of human infection under nonepizootic conditions may be transmission via contact with infected animals or humans. C1 INST PASTEUR,DAKAR,SENEGAL. CTR DIS CONTROL & PREVENT,ATLANTA,GA 30341. ORSTOM,INST FRANCAIS RECH SCI DEV COOPERAT,DAKAR,SENEGAL. USA,MED RES INST INFECT DIS,FREDERICK,MD. NR 57 TC 39 Z9 42 U1 0 U2 3 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JUN PY 1994 VL 50 IS 6 BP 663 EP 675 PG 13 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA NX126 UT WOS:A1994NX12600002 PM 7912905 ER PT J AU SIRISANTHANA, T PINYOPORNPANIT, V SIRISANTHANA, V STRICKMAN, D KELLY, DJ DASCH, GA AF SIRISANTHANA, T PINYOPORNPANIT, V SIRISANTHANA, V STRICKMAN, D KELLY, DJ DASCH, GA TI FIRST CASES OF SPOTTED-FEVER GROUP RICKETTSIOSIS IN THAILAND SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID SCRUB TYPHUS; TESTS AB The first three cases of spotted fever group rickettsiosis from Thailand are reported. The patients presented with fever, headache, lymphadenopathy, and petechial maculopapular rash. One patient also had an eschar and overt evidence of confusion. An indirect fluorescent antibody test, an indirect immunoperoxidase test, and an enzyme-linked immunosorbent assay demonstrated a broad, strong reactions of the sera of the patients with spotted fever group rickettsia antigens of many species, but not with antigens of typhus or scrub typhus rickettsiae. All three patients responded to treatment with a single dose of doxycycline. C1 ARMED FORCES RES INST MED SCI,BANGKOK 10400,THAILAND. USN,MED RES INST,DEPT INFECT DIS,VIRAL & RICKETTSIAL DIS PROGRAM,BETHESDA,MD 20889. RP SIRISANTHANA, T (reprint author), CHIANG MAI UNIV,FAC MED,CHIANG MAI 50002,THAILAND. NR 18 TC 34 Z9 35 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JUN PY 1994 VL 50 IS 6 BP 682 EP 686 PG 5 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA NX126 UT WOS:A1994NX12600004 PM 8024059 ER PT J AU LIN, AJ AGER, AL KLAYMAN, DL AF LIN, AJ AGER, AL KLAYMAN, DL TI ANTIMALARIAL ACTIVITY OF DIHYDROARTEMISININ DERIVATIVES BY TRANSDERMAL APPLICATION SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article AB In addition to artelinic acid, which was demonstrated previously to possess good prophylactic as well as curative antimalarial activity against Plasmodium berghei by transdermal administration, seven artemisinin derivatives in a gel formulation were assessed for their antimalarial activities in this study. Artemisinin, the parent compound of the series, showed moderate prophylactic but poor curative activity. Although methyl artelinate was more active against P. berghei than artelinic acid and sodium artelinate by subcutaneous injection, its transdermal curative and prophylactic activity was only comparable with or weaker than that of artelinic acid. Conversely, both dihydroartemisinin trimethylsilyl ether and dehydrodihydroartemisinin showed weaker antimalarial activity than artelinic acid by the subcutaneous route, yet exhibited comparable activity by transdermal administration. Artemether, a prodrug of dihydroartemisinin, is as effective as the parent dihydroartemisinin, and both compounds were the most potent agents among the compounds studied, with total prophylactic and curative doses of 30 mg/kg and 60 mg/kg, respectively. Complete absorption of dihydroartemisinin appears to occur within 5 min after application. In general, we found that the prophylactic dose is about half that of the curative dose under the protocols used in this study. This novel drug delivery system may be an easy and safe way to administer artemisinin-type antimalarials and also a good alternative dosage form for active compounds with solubility problems. C1 UNIV MIAMI,CTR TROP PARASIT DIS,MIAMI,FL 33152. RP LIN, AJ (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307, USA. NR 18 TC 5 Z9 7 U1 0 U2 5 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JUN PY 1994 VL 50 IS 6 BP 777 EP 783 PG 7 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA NX126 UT WOS:A1994NX12600019 PM 8024074 ER PT J AU LOOAREESUWAN, S VIRAVAN, C VANIJANONTA, S WILAIRATANA, P CHAROENLARP, P CANFIELD, CJ KYLE, DE AF LOOAREESUWAN, S VIRAVAN, C VANIJANONTA, S WILAIRATANA, P CHAROENLARP, P CANFIELD, CJ KYLE, DE TI RANDOMIZED TRIAL OF MEFLOQUINE-DOXYCYCLINE, AND ARTESUNATE-DOXYCYCLINE FOR TREATMENT OF ACUTE UNCOMPLICATED FALCIPARUM-MALARIA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID QINGHAOSU ARTEMISININ; ANTIMALARIAL-DRUGS; RESISTANCE; THAILAND AB One hundred nine adult patients with acute uncomplicated falciparum malaria were randomly selected to receive combinations of either doxycycline plus mefloquine or doxycycline plus artesunate. Fifty-four patients received mefloquine (1,250 mg divided between two doses of 750 and 500 mg six hours apart) with doxycycline and 55 patients received artesunate (300 mg total for 2.5 days; 100 mg followed by 50 mg every 12 hr for 2.5 days) with doxycycline. Doxycycline was administered in doses of 200 mg once a day for seven days. All patients were admitted to the hospital for 28 days to exclude reinfection. Ninety-seven patients completed the study; 12 patients left prior to completion of follow-up for reasons unrelated to their treatment. Cure rates for the two groups were 96% (46 of 48) for mefloquine plus doxycycline and 80% (39 of 49) for artesunate plus doxycycline. Mean fever and parasite clearance times were significantly shorter in the group that received artesunate plus doxycycline (38.7 and 41.3 hr) than mefloquine plus doxycycline (64.3 and 69.0 hr), respectively. In vitro drug sensitivity testing of selected isolates obtained prior to treatment indicated that eight of nine admission isolates were resistant to mefloquine; all isolates were susceptible to artesunate. Recrudescent isolates failed to show a pattern of decreased sensitivity to the drugs to which the parasites had been exposed during treatment; the studies showed decreased sensitivity to doxycycline in only two of eight isolates tested. The overall results of the study indicate that the combination of mefloquine plus doxycycline is effective and well-tolerated in patients suffering from acute uncomplicated malaria and is an alternative treatment for multidrug-resistant falciparum malaria in areas of severe drug resistance. C1 MAHIDOL UNIV,HOSP TROP DIS,FAC TROP MED,BANGKOK 10400,THAILAND. PHARMACEUT SYST INC,GAITHERSBURG,MD 20879. USA,ARMED FORCES RES INST MED SCI,MED COMPONENT,DEPT IMMUNOL & PARASITOL,BANGKOK,THAILAND. RP LOOAREESUWAN, S (reprint author), MAHIDOL UNIV,FAC TROP MED,DEPT CLIN TROP MED,420-6 RAJVITHEE RD,BANGKOK 10400,THAILAND. NR 18 TC 30 Z9 31 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JUN PY 1994 VL 50 IS 6 BP 784 EP 789 PG 6 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA NX126 UT WOS:A1994NX12600020 PM 8024075 ER PT J AU CLEMENT, S AF CLEMENT, S TI SCORECARD MEDICINE - MEASURING PROCESS AND OUTCOME SO ANNALS OF INTERNAL MEDICINE LA English DT Letter RP CLEMENT, S (reprint author), WALTER REED ARMY MED CTR,DEPT ARMY,MED CORP,WASHINGTON,DC 20307, USA. NR 5 TC 0 Z9 0 U1 0 U2 0 PU AMER COLL PHYSICIANS PI PHILADELPHIA PA INDEPENDENCE MALL WEST 6TH AND RACE ST, PHILADELPHIA, PA 19106-1572 SN 0003-4819 J9 ANN INTERN MED JI Ann. Intern. Med. PD JUN 1 PY 1994 VL 120 IS 11 BP 971 EP 972 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA NN110 UT WOS:A1994NN11000018 PM 8172447 ER PT J AU GRABENSTEIN, JD AF GRABENSTEIN, JD TI IMMUNOFACTS REVIEW (VOL 28, PG 287, 1994) SO ANNALS OF PHARMACOTHERAPY LA English DT Correction, Addition RP GRABENSTEIN, JD (reprint author), USA,MED DEPT CTR & SCH,FT SAM HOUSTON,TX 78234, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU HARVEY WHITNEY BOOKS CO PI CINCINNATI PA PO BOX 42696, CINCINNATI, OH 45242 SN 1060-0280 J9 ANN PHARMACOTHER JI Ann. Pharmacother. PD JUN PY 1994 VL 28 IS 6 BP 811 EP 811 PG 1 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA NV830 UT WOS:A1994NV83000038 ER PT J AU HOLFELS, E MCAULEY, J MACK, D MILHOUS, WK MCLEOD, R AF HOLFELS, E MCAULEY, J MACK, D MILHOUS, WK MCLEOD, R TI IN-VITRO EFFECTS OF ARTEMISININ ETHER, CYCLOGUANIL HYDROCHLORIDE (ALONE AND IN COMBINATION WITH SULFADIAZINE), QUININE SULFATE, MEFLOQUINE, PRIMAQUINE PHOSPHATE, TRIFLUOPERAZINE HYDROCHLORIDE, AND VERAPAMIL ON TOXOPLASMA-GONDII SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID PLASMODIUM-FALCIPARUM; ANTIMALARIAL-DRUGS; MALARIA; PHARMACOKINETICS; ANTAGONISTS; RESISTANCE; PROGUANIL; INVITRO; PYRIMETHAMINE; METABOLITES AB The in vitro effects of the following antimicrobial agents on Toxoplasma gondii tachyzoites were studied: artemisinin ether (arteether), cycloguanil hydrochloride (cycloguanil), mefloquine, primaquine phosphate, and quinine sulfate, as well as the calcium channel blocker verapamil and the calmodulin inhibitor trifluoperazine hydrochloride. Arteether at greater than or equal to 0.5 mu g/ml and cycloguanil at greater than or equal to 1.0 mu g/ml inhibited T. gondii in vitro. Cycloguanil (2.5 mu g/ml) combined with a noninhibitory concentration of sulfadiazine (25 mu g/ml) inhibited T. gondii more than cycloguanil alone. Neither primaquine phosphate, mefloquine, nor quinine sulfate had an inhibitory effect on intracellular T. gondii. Verapamil and trifluoperazine hydrochloride were not inhibitory at lower physiologic concentrations, but higher physiologic concentrations were toxic to cell cultures in vitro and therefore our assay could not be used to assess their effects. C1 MICHAEL REESE HOSP & MED CTR,DEPT MED,DIV INFECT DIS,CHICAGO,IL 60616. UNIV CHICAGO,CHICAGO,IL 60637. UNIV ILLINOIS,CHICAGO,IL. WALTER REED ARMY MED CTR,INST RES,WASHINGTON,DC. FU NIAID NIH HHS [AI 19645, AI 27530] NR 28 TC 27 Z9 28 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD JUN PY 1994 VL 38 IS 6 BP 1392 EP 1396 PG 5 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA NN770 UT WOS:A1994NN77000029 PM 8092843 ER PT J AU JOHNSON, B MARTIN, DD RESNICK, IG AF JOHNSON, B MARTIN, DD RESNICK, IG TI EFFICACY OF SELECTED RESPIRATORY PROTECTIVE EQUIPMENT CHALLENGED WITH BACILLUS-SUBTILIS SUBSP NIGER SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY LA English DT Note ID TUBERCULOSIS AB The efficacy of powered air-purifying respirators, surgical masks, dust/mist respirators, and high-efficiency respirators were tested,vith a biological aerosol under simulated breathing conditions. Protective ability ranged from 67 to 99.95%. The majority of penetration in negative-pressure respirators occurred at the face-mask interface rather than through the filter material. RP JOHNSON, B (reprint author), USA,DIV LIFE SCI MTL,DUGWAY PROVING GROUND,DUGWAY PROVING GROUND,UT 84022, USA. NR 12 TC 31 Z9 31 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0099-2240 J9 APPL ENVIRON MICROB JI Appl. Environ. Microbiol. PD JUN PY 1994 VL 60 IS 6 BP 2184 EP 2186 PG 3 WC Biotechnology & Applied Microbiology; Microbiology SC Biotechnology & Applied Microbiology; Microbiology GA NN765 UT WOS:A1994NN76500073 PM 16349306 ER PT J AU KROUTIL, RT COMBS, RJ KNAPP, RB SMALL, GW AF KROUTIL, RT COMBS, RJ KNAPP, RB SMALL, GW TI AUTOMATED DETECTION OF ACETONE, METHYL ETHYL KETONE, AND SULFUR-HEXAFLUORIDE BY DIRECT ANALYSIS OF FOURIER-TRANSFORM INFRARED INTERFEROGRAMS SO APPLIED SPECTROSCOPY LA English DT Article DE ENVIRONMENTAL MONITORING; INFRARED; DIGITAL FILTERING; INTERFEROMETRY ID MICHELSON INTERFEROMETER; MIRROR VELOCITY; REMOTE AB The lack of a valid background reference spectrum for many Fourier transform infrared (FT-IR) spectrometric open-air monitoring applications limits the ability to perform quantitative measurements. Direct interferogram analysis suppresses the broad-band detector envelope and maintains the spectral signature of interest to circumvent this limitation. The background suppression approach uses a combination of interferogram segment selection, digital filtering, and pattern discrimination techniques. The spectral band location, width, and contour of the vapor determine the parameters necessary for background suppression. Interferogram segment selection relies principally on the spectral bandwidth. Digital filter design employs inputs of both spectral band location and width. Pattern discrimination methods consider the variation in the spectral band contour with band intensity. FT-IR spectrometer measurements from both laboratory and open-air trials demonstrate the utility of the background suppression approach with analytes of acetone, methyl ethyl ketone (MEK), and sulfur hexafluoride (SF6). C1 OHIO UNIV, DEPT CHEM, CTR INTELLIGENT CHEM INSTRUMENTAT, ATHENS, OH 45701 USA. RP KROUTIL, RT (reprint author), USA, EDGEWOOD RES DEV & ENGN CTR, ABERDEEN PROVING GROUND, MD 21010 USA. NR 31 TC 24 Z9 24 U1 0 U2 8 PU SOC APPLIED SPECTROSCOPY PI FREDERICK PA 5320 SPECTRUM DRIVE SUITE C, FREDERICK, MD 21703 USA SN 0003-7028 J9 APPL SPECTROSC JI Appl. Spectrosc. PD JUN PY 1994 VL 48 IS 6 BP 724 EP 732 DI 10.1366/000370294774368901 PG 9 WC Instruments & Instrumentation; Spectroscopy SC Instruments & Instrumentation; Spectroscopy GA NW363 UT WOS:A1994NW36300016 ER PT J AU SPERLING, LC SKELTON, HG SMITH, KJ SAU, P FRIEDMAN, K AF SPERLING, LC SKELTON, HG SMITH, KJ SAU, P FRIEDMAN, K TI FOLLICULAR DEGENERATION SYNDROME IN MEN SO ARCHIVES OF DERMATOLOGY LA English DT Article AB Background and Design: Follicular degeneration syndrome (FDS, formerly called hot comb alopecia) has only been described in black women. The clinical and histologic features of eight black men with a scarring alopecia resembling FDS were studied. Observations: All eight men had evidence of scarring alopecia, which was most prominent on the crown of the scalp. None of the men were using chemical or physical modalities to straighten or style the hair. Overall, this group of men had more evidence of active inflammation than did the previously described women with FDS. The histologic features in the men were identical to those found in women with FDS. The presence of premature desquamation of the inner root sheath and migration of the hair shaft through the outer root sheath serve as histologic markers of FDS and separate it histologically from other forms of scarring alopecia. Conclusions: Follicular degeneration syndrome is a common form of scarring alopecia in black men, just as it is in black women. In men, there is no association between chemical or mechanical hair styling techniques (eg, the ''hot comb'') and onset, progression, or severity of disease. The histologic features of FDS in men are identical to those in women. C1 ARMED FORCES INST PATHOL,DERMATOPATHOL BRANCH,WASHINGTON,DC 20306. WALTER REED ARMY INST RES,WASHINGTON,DC. BETHESDA DERMATPATHOL LAB,BETHESDA,MD. RP SPERLING, LC (reprint author), WALTER REED ARMY MED CTR,DERMATOL SERV,WASHINGTON,DC 20307, USA. NR 4 TC 47 Z9 47 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0003-987X J9 ARCH DERMATOL JI Arch. Dermatol. PD JUN PY 1994 VL 130 IS 6 BP 763 EP 769 DI 10.1001/archderm.130.6.763 PG 7 WC Dermatology SC Dermatology GA NQ995 UT WOS:A1994NQ99500010 PM 8002648 ER PT J AU MACKEY, SL SMITH, KJ YEAGER, JK AF MACKEY, SL SMITH, KJ YEAGER, JK TI RADIOLOGICAL CASES OF THE MONTH - PICTURE OF THE MONTH - LYMPHANGIOMA CIRCUMSCRIPTUM SO ARCHIVES OF PEDIATRICS & ADOLESCENT MEDICINE LA English DT Note ID LASER C1 WALTER REED ARMY INST RES,WASHINGTON,DC. RP MACKEY, SL (reprint author), USN,NATL MED CTR,DEPT DERMATOL,BETHESDA,MD, USA. NR 11 TC 2 Z9 2 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 1072-4710 J9 ARCH PEDIAT ADOL MED JI Arch. Pediatr. Adolesc. Med. PD JUN PY 1994 VL 148 IS 6 BP 609 EP 610 PG 2 WC Pediatrics SC Pediatrics GA NQ154 UT WOS:A1994NQ15400011 PM 8193686 ER PT J AU ROTH, BJ MARTIN, RR FOLEY, K BARCIA, PJ KENNEDY, P AF ROTH, BJ MARTIN, RR FOLEY, K BARCIA, PJ KENNEDY, P TI ROENTGENOGRAPHIC EVALUATION OF THE CERVICAL-SPINE - A SELECTIVE APPROACH SO ARCHIVES OF SURGERY LA English DT Article ID BLUNT TRAUMA; RADIOGRAPHY; INJURIES; PATIENT AB Background: To determine if routine radiographic evaluation of the cervical spine could be eliminated in the alert, sober trauma patient who has no neck pain, tenderness, or other major injuries without a significant increase in missed occult injury. Design: Prospective cohort study. Setting: Emergency department and general surgery service at a military tertiary medical center. Main Outcome Measure: Those patients with cervical spine injuries. Results: Sixteen patients (2%) had cervical spine injuries, all had signs and/or symptoms of their injury on presentation. Ninety-six patients (14%) who were not intoxicated and had no neck pain, tenderness, or other major injuries were evaluated. None of these patients had abnormal cervical spine studies. Two hundred ninety patients (43%) were followed up between 30 to 150 days. No missed injuries were noted. Conclusions: These results indicate that blunt trauma patients may not require cervical spine roentgenography if they meet the following criteria: absence of mental status changes, intoxication, neck pain or tenderness, neurologic signs or symptoms, or simultaneous major distracting injury. Because of the small incidence of cervical spine injuries, further studies are necessary to evaluate the positive predictive value of history and physical examination of the cervical spine in a trauma patient. RP ROTH, BJ (reprint author), TRIPLER ARMY MED CTR,DEPT GEN SURG,HONOLULU,HI 96859, USA. NR 15 TC 37 Z9 37 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0004-0010 J9 ARCH SURG-CHICAGO JI Arch. Surg. PD JUN PY 1994 VL 129 IS 6 BP 643 EP 645 PG 3 WC Surgery SC Surgery GA NQ148 UT WOS:A1994NQ14800015 PM 8204040 ER PT J AU COLLINS, CM RACINE, CH WALSH, ME AF COLLINS, CM RACINE, CH WALSH, ME TI THE PHYSICAL, CHEMICAL, AND BIOLOGICAL EFFECTS OF CRUDE-OIL SPILLS AFTER 15 YEARS ON A BLACK SPRUCE FOREST, INTERIOR ALASKA SO ARCTIC LA English DT Article DE CRUDE OIL; SPILL; TERRESTRIAL; TAIGA; PERMAFROST; BLACK SPRUCE FOREST; INTERIOR ALASKA ID ERIOPHORUM-VAGINATUM; PLANT-COMMUNITIES; GROWTH; NWT AB The effects of two large experimental crude oil spills conducted in the winter and summer of 1976 in a permafrost-underlain black spruce forest of interior Alaska were assessed 15 years after the spills. Effects on permafrost, as determined from measurements of active layer thaw depths and of the total amount of ground subsidence, were far more pronounced on the winter spill due to a larger surface-oiled area. The winter spill also had a more drastic effect on the vegetation. Where the black, asphalt-like surface oil was present, black spruce mortality was 100 % and there was very little live plant cover except for cotton grass tussocks. Changes in oil chemistry varied with depth; surface samples had signs of microbiological degradation, whereas some subsurface samples taken just above the permafrost had no evidence of degradation and still contained volatile fractions. RP COLLINS, CM (reprint author), USA,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 29 TC 12 Z9 13 U1 2 U2 4 PU ARCTIC INST N AMER PI CALGARY PA UNIV OF CALGARY 2500 UNIVERSITY DRIVE NW 11TH FLOOR LIBRARY TOWER, CALGARY AB T2N 1N4, CANADA SN 0004-0843 J9 ARCTIC JI Arctic PD JUN PY 1994 VL 47 IS 2 BP 164 EP 175 PG 12 WC Environmental Sciences; Geography, Physical SC Environmental Sciences & Ecology; Physical Geography GA NX122 UT WOS:A1994NX12200008 ER PT J AU ROTHBERG, JM AF ROTHBERG, JM TI CHALLENGES IN MILITARY HEALTH-CARE - PERSPECTIVES ON HEALTH-STATUS AND THE PROVISION OF CARE - STANLEY,J, BLAIR,JD SO ARMED FORCES & SOCIETY LA English DT Book Review RP ROTHBERG, JM (reprint author), WALTER REED ARMY INST RES,DEPT MIL PSYCHIAT,WASHINGTON,DC 20307, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU TRANSACTION PERIOD CONSORTIUM PI NEW BRUNSWICK PA DEPT 3091 RUTGERS-THE STATE UNIV OF NJ, NEW BRUNSWICK, NJ 08903 SN 0095-327X J9 ARMED FORCES SOC JI Armed Forces Soc. PD SUM PY 1994 VL 20 IS 4 BP 637 EP 639 DI 10.1177/0095327X9402000410 PG 3 WC Political Science; Sociology SC Government & Law; Sociology GA PC757 UT WOS:A1994PC75700012 ER PT J AU LANG, GH PRESCOTT, JF WILLIAMS, JC AF LANG, GH PRESCOTT, JF WILLIAMS, JC TI SEROLOGICAL RESPONSE IN SHEEP VACCINATED AGAINST COXIELLA-BURNETTI (Q-FEVER) SO CANADIAN VETERINARY JOURNAL-REVUE VETERINAIRE CANADIENNE LA English DT Note ID IMMUNITY C1 USA,MED RES INST INFECT DIS,FREDERICK,MD 21701. RP LANG, GH (reprint author), UNIV GUELPH,ONTARIO VET COLL,DEPT VET MICROBIOL & IMMUNOL,GUELPH N1G 2W1,ONTARIO,CANADA. NR 10 TC 5 Z9 5 U1 0 U2 1 PU CANADIAN VET MED ASSOC PI OTTAWA PA 339 BOOTH ST ATTN: KIMBERLY ALLEN-MCGILL, OTTAWA ON K1R 7K1, CANADA SN 0008-5286 J9 CAN VET J JI Can. Vet. J.-Rev. Vet. Can. PD JUN PY 1994 VL 35 IS 6 BP 373 EP 374 PG 2 WC Veterinary Sciences SC Veterinary Sciences GA PE287 UT WOS:A1994PE28700013 PM 8069839 ER PT J AU GADDIPATI, JP MCLEOD, DG HEIDENBERG, HB SESTERHENN, IA FINGER, MJ MOUL, JW SRIVASTAVA, S AF GADDIPATI, JP MCLEOD, DG HEIDENBERG, HB SESTERHENN, IA FINGER, MJ MOUL, JW SRIVASTAVA, S TI FREQUENT DETECTION OF CODON-877 MUTATION IN THE ANDROGEN RECEPTOR GENE IN ADVANCED PROSTATE CANCERS SO CANCER RESEARCH LA English DT Note ID HORMONAL-THERAPY; INSENSITIVITY; BENIGN; FAMILY AB Prostatic tissue specimens derived from transurethral resections of patients with metastatic prostate cancer were analyzed for genetic alterations in the hormone-binding domain of the androgen receptor (AR) gene. Direct sequencing of the polymerase chain reaction derived DNAs of 6 of 24 specimens revealed a codon 877 mutation (ACT --> GCT, Thr --> Ala) in the hormone-binding domain of the AR gene. This same AR mutation has been reported previously in a metastatic prostate cancer cell line, LNCaP, where this mutation confers upon the AR an altered ligand-binding specificity which is stimulated by estrogens, progestagens, and antiandrogens. It is possible that analogous to an activated/altered growth factor receptor oncogene, codon 877 mutant AR with altered ligand binding may provide a selective growth advantage in the genesis of a subset of advanced prostate cancer. Although estrogens are used infrequently, antiandrogens are used increasingly in hormonal therapy for patients with advanced prostate cancer. The stimulatory effect of these therapeutic agents on the codon 877 mutant AR further suggests that this frequently observed AR mutation may contribute to the treatment refractory disease. C1 UNIFORMED SERV UNIV HLTH SCI,F EDWARD HEBERT SCH MED,DEPT SURG,CTR PROSTATE DIS RES,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,UROL SERV,WASHINGTON,DC 20307. ARMED FORCES INST PATHOL,WASHINGTON,DC. NR 25 TC 287 Z9 291 U1 1 U2 1 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA PUBLIC LEDGER BLDG, SUITE 816, 150 S. INDEPENDENCE MALL W., PHILADELPHIA, PA 19106 SN 0008-5472 J9 CANCER RES JI Cancer Res. PD JUN 1 PY 1994 VL 54 IS 11 BP 2861 EP 2864 PG 4 WC Oncology SC Oncology GA NN724 UT WOS:A1994NN72400012 PM 8187068 ER PT J AU DEZZUTTI, CS RUDOLPH, DL DHAWAN, S LAL, RB AF DEZZUTTI, CS RUDOLPH, DL DHAWAN, S LAL, RB TI MODULATION OF HTLV-II-ASSOCIATED SPONTANEOUS LYMPHOCYTE-PROLIFERATION BY BETA-2 INTEGRIN CD11A/CD18 INVOLVES INTERACTION WITH ITS COGNATE LIGAND, CD54 SO CELLULAR IMMUNOLOGY LA English DT Article ID T-CELL LEUKEMIA; VIRUS TYPE-I; INTERCELLULAR-ADHESION MOLECULE-1; ACTIVATION; EXPRESSION; RECEPTORS; I/II; MYELOPATHY; ANTIBODIES; INFECTION AB In vitro culture of lymphocytes from persons infected by human T-lymphocyte virus type II (HTLV-II) results in spontaneous proliferation in the absence of any exogenous stimuli. The present investigation examined the role of integrin molecules in spontaneous lymphocyte proliferation (SLP) in persons infected with HTLV-II (n = 18)and normal controls (n = 16). Phenotypic analysis of SLP cells on Day 8 demonstrated no change in the surface expression of CD24 (beta 1), CD49b,d,e, and f (alpha-chains) compared with cells from normal centrols; however, there was an increase of CD29 expression on SLP cells on Day 8 (77.2 +/- 5.1%) compared with Day 0 (53.2 +/- 3.1%; P < 0.01). Furthermore, addition of extracellular matrix proteins, fibronectin, laminin, or collagen (beta 1 integrin ligands) did not alter either the proliferative responses or the adhesion clusters in either groups. Analysis of beta 2 integrins on SLP cells showed not only an increased cell surface density of both CD18 and CD11a but also differential expansion of CD8+ T-cells coexpressing CD18 (54.0 +/- 10.3%), CD11a (53.7 +/- 8.1%), and S6F1, an epitope of CD11a, (65.3 +/- 7.8%) on Day 8 compared with Day 0 (20.0 +/- 2.5%, 19.3 +/- 1.9%, and 38.0 +/- 7.0%, respectively). Monoclonal antibodies to CD18 and CD11a inhibited SLP by 55 +/- 6.3% in HTLV-II-infected persons in a dose-dependent manner. The inhibition of SLP by anti-beta 2 antibodies was not due to negative signaling, since these antibodies did not inhibit anti-CD3-stimulated proliferation of normal lymphocytes. Moreover, monoclonal antibodies to CD54, the ligand for CD11a, inhibited the SLP in the majority of HTLV-II-infected persons studied. Taken together, these data suggest that SLP by PBL from HTLV-II-infected individuals is mediated through increased expression of beta 2 integrins that can modulate cognate receptor/ligand interactions on the cell surface of autologous proliferating cells. C1 WALTER REED ARMY INST RES,WASHINGTON,DC 20307. DEPT CELLULAR IMMUNOL,WASHINGTON,DC 20307. RP DEZZUTTI, CS (reprint author), CTR DIS CONTROL & PREVENT,NATL CTR INFECT DIS,DIV VIRAL & RICKETTSIAL DIS,ATLANTA,GA 30333, USA. NR 25 TC 9 Z9 9 U1 0 U2 0 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0008-8749 J9 CELL IMMUNOL JI Cell. Immunol. PD JUN PY 1994 VL 156 IS 1 BP 113 EP 123 DI 10.1006/cimm.1994.1157 PG 11 WC Cell Biology; Immunology SC Cell Biology; Immunology GA NP117 UT WOS:A1994NP11700010 PM 7911072 ER PT J AU CARDELLO, AV AF CARDELLO, AV TI PSYCHOPHYSICAL AND METAPHYSICAL MUSINGS ON THE ROAD TO ROME SO CEREAL FOODS WORLD LA English DT Article ID MIXTURES RP CARDELLO, AV (reprint author), USA,NATICK RES DEV & ENGN CTR,NATICK,MA 01760, USA. NR 4 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC CEREAL CHEMISTS PI ST PAUL PA 3340 PILOT KNOB RD, ST PAUL, MN 55121-2097 SN 0146-6283 J9 CEREAL FOOD WORLD JI Cereal Foods World PD JUN PY 1994 VL 39 IS 6 BP 461 EP 465 PG 5 WC Food Science & Technology SC Food Science & Technology GA NU411 UT WOS:A1994NU41100009 ER PT J AU MARTIN, TW GAUCHER, J PUPA, LE SEAWORTH, JF AF MARTIN, TW GAUCHER, J PUPA, LE SEAWORTH, JF TI RESPONSE TO UPRIGHT EXERCISE AFTER CARDIAC TRANSPLANTATION SO CLINICAL CARDIOLOGY LA English DT Article DE HEART CATHETERIZATION; OXYGEN CONSUMPTION; BLOOD PRESSURE; HEMODYNAMIC; LACTIC ACID ID CHRONIC HEART-FAILURE; SKELETAL-MUSCLE; DYNAMIC EXERCISE; CARDIORESPIRATORY RESPONSES; PULMONARY-HYPERTENSION; SUPINE EXERCISE; BLOOD-FLOW; FOLLOW-UP; HEMODYNAMICS; RECIPIENTS AB There is little information on the hemodynamic response to upright exercise in patients who have undergone cardiac transplantation. We compared the hemodynamic and metabolic response to upright bicycle exercise in 11 patients with heart transplants and 12 controls. Patients performed two tests-a steady-state test with a right heart catheter and a maximal incremental test. During steady-state exercise at 20% of their predicted maximum workload, patients with heart transplants had a higher (mean +/- SD, p < 0.05) heart rate (108 +/- 11 vs. 96 +/- 15 beats/min), mean systemic blood pressure (116 +/- 17 vs. 101 +/- 11 mmHg), mean pulmonary artery pressure (29 +/- 9 vs. 22 +/- 3 mmHg), mean pulmonary wedge pressure (14 +/- 6 vs. 9 +/- 2), pulmonary (302 +/- 101 vs. 220 +/- 50 d-Sec-cm-5 - m2) and systemic (2049 +/- 531 vs. 1459 +/- 520) resistance indices, and lactate concentration (3.4 +/- 1.7 vs. 1.7 +/- 0.4 mmol/l), and a lower stroke index (39 +/- 8 vs. 50 +/- 8 ml/m2) compared with controls. Cardiac index, fight atrial pressure, and mixed venous oxygen saturation were similar. During die maximal exercise test, patients with heart transplants achieved a significantly lower percentage of predicted maximum heart rate (77 +/- 13 vs. 91 +/- 8%), workload (70 +/- 25 vs. 102 +/- 23%), oxygen consumption (63 +/- 11 vs. 108 +/- 19%), and ventilation (67 +/- 18 vs. 89 +/-15%) compared with controls. Heart transplant patients also had a lower blood pressure and anaerobic threshold. We conclude that heart transplant patients have an altered hemodynamic and metabolic response to upright bicycle exercise. C1 BROOKE ARMY MED CTR,CARDIOL SERV,FT SAM HOUSTON,TX 78234. NR 38 TC 6 Z9 7 U1 0 U2 0 PU CLINICAL CARDIOLOGY PUBL CO PI MAHWAH PA PO BOX 832, MAHWAH, NJ 07430-0832 SN 0160-9289 J9 CLIN CARDIOL JI Clin. Cardiol. PD JUN PY 1994 VL 17 IS 6 BP 292 EP 300 PG 9 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA NN480 UT WOS:A1994NN48000003 PM 8070146 ER PT J AU PAPADOS, PP ROSCHKE, PN AF PAPADOS, PP ROSCHKE, PN TI A NEW METHOD FOR FAILURE PREDICTION OF SR-200 BERYLLIUM SHEET STRUCTURES SO COMPUTING SYSTEMS IN ENGINEERING LA English DT Article AB Contemporary applications of failure criteria frequently incorporate two-dimensional or simplified three-dimensional methodologies for prediction of failure stresses. Motivation behind the development of a new multi-dimensional failure criterion is due mainly to the lack of a sufficiently accurate mathematical tool that accounts for the behavior of brittle material with anisotropic properties. Such a criterion should be able to provide a reliable maximum load estimate so that design of the structure is not penalized in terms of excessive weight requirements. The failure criterion developed is represented by a fracture surface in a six-dimensional stress space. The criterion is applied for failure prediction of SR-200 beryllium sheet structures. a non-homogeneous orthotropic material used widely in space applications. Two experiments are used to verify the criterion. C1 TEXAS A&M UNIV,DEPT CIVIL ENGN,COLLEGE STN,TX 77843. RP PAPADOS, PP (reprint author), WATERWAYS EXPT STN,VICKSBURG,MS 39180, USA. NR 15 TC 0 Z9 0 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0956-0521 J9 COMPUT SYST ENG JI Comput. Syst. Eng. PD JUN PY 1994 VL 5 IS 3 BP 285 EP 293 DI 10.1016/0956-0521(94)90007-8 PG 9 WC Computer Science, Interdisciplinary Applications; Engineering, Multidisciplinary SC Computer Science; Engineering GA PJ756 UT WOS:A1994PJ75600007 ER PT J AU DUCEY, JP AF DUCEY, JP TI ARTERIAL-MIXED VENOUS CARBON-DIOXIDE TENSION DIFFERENCE IN HEMORRHAGE AND RESUSCITATION - REPLY SO CRITICAL CARE MEDICINE LA English DT Letter RP DUCEY, JP (reprint author), BROOKE ARMY MED CTR,FT SAM HOUSTON,TX, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD JUN PY 1994 VL 22 IS 6 BP 1064 EP 1064 DI 10.1097/00003246-199406000-00030 PG 1 WC Critical Care Medicine SC General & Internal Medicine GA PL759 UT WOS:A1994PL75900029 ER PT J AU MILLER, B KLEIN, TA OPSAHL, MS AF MILLER, B KLEIN, TA OPSAHL, MS TI THE EFFECT OF A SURGICAL LUBRICANT ON IN-VIVO SPERM PENETRATION OF CERVICAL-MUCUS SO FERTILITY AND STERILITY LA English DT Note DE LUBRICATION; CERVICAL MUCUS; SPERM MOTILITY; SPERMICIDAL EFFECTS; INFERTILITY C1 USN,NATL NAVAL MED CTR,DEPT GYNECOL & OBSTET,DIV REPROD ENDOCRINOL,BETHESDA,MD 20889. UNIFORMED SERV UNIV HLTH SCI,DEPT OBSTET & GYNECOL,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,DEPT OBSTET & GYNECOL,DIV REPROD ENDOCRINOL,WASHINGTON,DC 20307. OI Opsahl, Michael/0000-0002-8754-7943 NR 5 TC 6 Z9 7 U1 0 U2 3 PU AMER SOC REPRODUCTIVE MEDICINE PI BIRMINGHAM PA 1209 MONTGOMERY HIGHWAY, BIRMINGHAM, AL 35216-2809 SN 0015-0282 J9 FERTIL STERIL JI Fertil. Steril. PD JUN PY 1994 VL 61 IS 6 BP 1171 EP 1173 PG 3 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA NN391 UT WOS:A1994NN39100032 PM 8194639 ER PT J AU BRANDT, HE AF BRANDT, HE TI SOLUTION TO TORSION RELATIONS IN FINSLER-SPACETIME TANGENT BUNDLE SO FOUNDATIONS OF PHYSICS LETTERS LA English DT Article DE SPACETIME TANGENT BUNDLE; FINSLER SPACETIME; KAHLER MANIFOLD; BUNDLE TORSION; GAUGE CURVATURE FIELD; ALMOST COMPLEX STRUCTURE AB In the Finsler-spacetime tangent bundle, a simple solution is determined to the torsion relations that were obtained previously to maintain (1) compatibility with Caxtan's theory of Finsler space, (2) the almost complex structure, and (3) the vanishing of the covariant derivative of the almost complex structure. RP BRANDT, HE (reprint author), USA,RES LAB,2800 POWDER MILL RD,ADELPHI,MD 20783, USA. NR 0 TC 6 Z9 6 U1 0 U2 0 PU PLENUM PUBL CORP PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 SN 0894-9875 J9 FOUND PHYS LETT JI Found. Phys. Lett. PD JUN PY 1994 VL 7 IS 3 BP 297 EP 301 DI 10.1007/BF02275256 PG 5 WC Physics, Multidisciplinary SC Physics GA NT536 UT WOS:A1994NT53600006 ER PT J AU HEWITT, AD SHOOP, SA AF HEWITT, AD SHOOP, SA TI RAPID ASSESSMENT OF TRICHLOROETHYLENE IN-GROUND WATER SO GROUND WATER MONITORING AND REMEDIATION LA English DT Article AB On-site analysis of trichloroethylene (TCE) in aqueous samples by headspace sample preparation and gas chromatography (HS/GC) provides for quick and precise concentration estimates. This analytical approach is well suited for the on-site determination of volatile organic compounds (VOCs) in a variety of sample matrices, including ground water and saturated and unsatured soils. For these reasons, HS/GC can be used to establish analyte concentrations on a near real time basis to help select appropriate casing material during monitoring well installation. This application and the collection of multiple well samples during sampling events facilitates the hydrogeological site interpretation and the formulation of remediation strategies. RP HEWITT, AD (reprint author), CRREL,72 LYME RD,HANOVER,NH 03755, USA. NR 0 TC 3 Z9 3 U1 0 U2 5 PU GROUND WATER PUBLISHING CO PI WESTERVILLE PA 601 DEMPSEY RD, WESTERVILLE, OH 43081 SN 1069-3629 J9 GROUND WATER MONIT R JI Ground Water Monit. Remediat. PD SUM PY 1994 VL 14 IS 3 BP 116 EP 122 DI 10.1111/j.1745-6592.1994.tb00472.x PG 7 WC Water Resources SC Water Resources GA NZ373 UT WOS:A1994NZ37300008 ER PT J AU PARKER, LV RANNEY, TA AF PARKER, LV RANNEY, TA TI EFFECT OF CONCENTRATION ON SORPTION OF DISSOLVED ORGANICS BY PVC, PTFE, AND STAINLESS-STEEL WELL CASINGS SO GROUND WATER MONITORING AND REMEDIATION LA English DT Article AB This report examines sorption of low ppb levels of organic solutions by polytetrafluoroethylene (PTFE), rigid polyvinyl chloride (PVC), and stainless steel 304 and 316 well casings. Nineteen organics were selected, including several munitions and chlorinated solvents. Compounds were selected to offer a range of physical properties, such as solubility in water, octanol/water partition coefficient, and molecular structure. When these results were compared with the results from a similar study conducted at ppm levels, the rate and extent of sorption by PTFE and PVC were the same as seen previously For almost all analytes. There were no losses of any compounds associated with stainless steel. At these low levels (ppm and ppb), the rate of diffusion within the polymer (PVC and PTFE) is independent of concentration. Only with PFTE are the rates rapid enough to be of concern when monitoring for some contaminants in ground water. Tetrachloroethylene was the compound PTFE sorbed the most rapidly. The study showed that PVC well casings are suitable for monitoring low levels (ppm and ppb) of organics. RP PARKER, LV (reprint author), USA,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 0 TC 11 Z9 11 U1 0 U2 3 PU GROUND WATER PUBLISHING CO PI WESTERVILLE PA 601 DEMPSEY RD, WESTERVILLE, OH 43081 SN 1069-3629 J9 GROUND WATER MONIT R JI Ground Water Monit. Remediat. PD SUM PY 1994 VL 14 IS 3 BP 139 EP 149 DI 10.1111/j.1745-6592.1994.tb00475.x PG 11 WC Water Resources SC Water Resources GA NZ373 UT WOS:A1994NZ37300011 ER PT J AU PARKER, LV AF PARKER, LV TI THE EFFECTS OF GROUND-WATER SAMPLING DEVICES ON WATER-QUALITY - A LITERATURE-REVIEW (VOL 14, PG 130, 1994) SO GROUND WATER MONITORING AND REMEDIATION LA English DT Correction, Addition RP PARKER, LV (reprint author), USA,COLD REG RES & ENGN LAB,APPL RES BRANCH,72 LYME RD,HANOVER,NH 03755, USA. NR 0 TC 2 Z9 2 U1 0 U2 2 PU GROUND WATER PUBLISHING CO PI WESTERVILLE PA 601 DEMPSEY RD, WESTERVILLE, OH 43081 SN 1069-3629 J9 GROUND WATER MONIT R JI Ground Water Monit. Remediat. PD SUM PY 1994 VL 14 IS 3 BP 275 EP 275 PG 1 WC Water Resources SC Water Resources GA NZ373 UT WOS:A1994NZ37300020 ER PT J AU CARIN, L FELSEN, LB AF CARIN, L FELSEN, LB TI WAVE-ORIENTED DATA-PROCESSING FOR FREQUENCY-DOMAIN AND TIME-DOMAIN SCATTERING BY NONUNIFORM TRUNCATED ARRAYS SO IEEE ANTENNAS AND PROPAGATION MAGAZINE LA English DT Article ID TRANSIENT-RESPONSE; SWITCHED ANTENNAS; EXTRACTING POLES; SYSTEM C1 USA,RES LAB,WASHINGTON,DC 20310. RP CARIN, L (reprint author), POLYTECH INST NEW YORK,DEPT ELECT ENGN,BROOKLYN,NY 11201, USA. NR 38 TC 23 Z9 23 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 1045-9243 J9 IEEE ANTENNAS PROPAG JI IEEE Antennas Propag. Mag. PD JUN PY 1994 VL 36 IS 3 BP 29 EP 43 DI 10.1109/74.294241 PG 15 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA PT612 UT WOS:A1994PT61200006 ER PT J AU YANG, D GARRETT, JH SHAW, DS RENDELL, LA AF YANG, D GARRETT, JH SHAW, DS RENDELL, LA TI AN INTELLIGENT SYMBOL USAGE ASSISTANT FOR CAD SYSTEMS SO IEEE EXPERT-INTELLIGENT SYSTEMS & THEIR APPLICATIONS LA English DT Article ID NEURAL NETWORK; NEOCOGNITRON; RECOGNITION C1 CARNEGIE MELLON UNIV,DEPT CIVIL ENGN,PITTSBURGH,PA 15213. USA,CONSTRUCT ENGN RES LAB,CHAMPAIGN,IL. RP YANG, D (reprint author), UNIV ILLINOIS,BECKMAN INST,405 N MATHENS AVE,URBANA,IL 61801, USA. NR 9 TC 1 Z9 1 U1 0 U2 1 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1264 SN 0885-9000 J9 IEEE EXPERT JI IEEE Expert-Intell. Syst. Appl. PD JUN PY 1994 VL 9 IS 3 BP 32 EP 41 DI 10.1109/64.311277 PG 10 WC Computer Science, Artificial Intelligence; Engineering, Electrical & Electronic SC Computer Science; Engineering GA PD594 UT WOS:A1994PD59400005 ER PT J AU SHEN, H PAMULAPATI, J WRABACK, M TAYSINGLARA, M DUTTA, M KUO, HC LU, Y AF SHEN, H PAMULAPATI, J WRABACK, M TAYSINGLARA, M DUTTA, M KUO, HC LU, Y TI HIGH-CONTRAST OPTICAL MODULATOR BASED ON ELECTRICALLY TUNABLE POLARIZATION ROTATION AND PHASE RETARDATION IN UNIAXIALLY STRAINED (100) MULTIPLE-QUANTUM WELLS SO IEEE PHOTONICS TECHNOLOGY LETTERS LA English DT Article AB We report a novel approach,to the design of normal incidence multiple quantum well light modulators. The quantum confined Stark effect is utilized to tune the light polarization rotation and phase retardation created by a thermally induced in-plane anisotropic strain. An exceedingly high contrast ratio of 5000: 1 is demonstrated for a normally-on device at room temperature. C1 GEOCENTERS INC,LAKE HOPATCONG,NJ 07849. RUTGERS STATE UNIV,DEPT ELECT & COMP ENGN,PISCATAWAY,NJ 08855. RP SHEN, H (reprint author), USA,RES LAB,ELECTR & POWER SOURCES DIRECTORATE,FT MONMOUTH,NJ 07703, USA. NR 6 TC 20 Z9 20 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 1041-1135 J9 IEEE PHOTONIC TECH L JI IEEE Photonics Technol. Lett. PD JUN PY 1994 VL 6 IS 6 BP 700 EP 702 DI 10.1109/68.300167 PG 3 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA NW853 UT WOS:A1994NW85300009 ER PT J AU REKIOUAK, A CHEO, BR WURTHMAN, G BATES, C AF REKIOUAK, A CHEO, BR WURTHMAN, G BATES, C TI A SLOW-WAVE STRUCTURE FOR GYRO-TWA H11 OPERATION SO IEEE TRANSACTIONS ON MICROWAVE THEORY AND TECHNIQUES LA English DT Note ID AMPLIFIER; MODE AB It was shown in a previous work, that it is possible to achieve high quality amplifier application based on the basic cyclotron maser instability principle: the narrow bandwidth of gyro amplifiers could be overcome using a disc loaded circuit in the hybrid mode interaction. In this work, we use the Galerkin method to analyze the cold circuit structure, obtaining both its dispersion characteristics and its characteristic impedance. This effort complements an earlier effort, where a polynomial obtained from experimental data was used for the cold circuit dispersion characteristic. The complete behavior of the actual structure is studied: first, the propagation of the hybrid H11 mode in the cold circuit; next, the finite length of the real structure is taken into account to derive the characteristic impedance of the actual circuit Numerical and experimental results are compared and shown to match accurately throughout the wide frequency range used. C1 POLYTECH INST NEW YORK,BROOKLYN,NY 11201. USARL,ELECTR & POWER SOURCE DIRECTORATE,FT MONMOUTH,NJ 07703. RP REKIOUAK, A (reprint author), ECOLE SUPER ELECT,SIGNAUX & SYST LAB,F-91192 GIF SUR YVETTE,FRANCE. NR 28 TC 3 Z9 3 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9480 J9 IEEE T MICROW THEORY JI IEEE Trans. Microw. Theory Tech. PD JUN PY 1994 VL 42 IS 6 BP 1091 EP 1094 DI 10.1109/22.293584 PG 4 WC Engineering, Electrical & Electronic SC Engineering GA NV883 UT WOS:A1994NV88300025 ER PT J AU DECOSTER, MA YOURICK, DL AF DECOSTER, MA YOURICK, DL TI DEVELOPMENT OF GLUTAMATE-STIMULATED PHOSPHATIDYLINOSITOL METABOLISM IN PRIMARY NEURONAL AND ASTROCYTE CULTURES SO INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE LA English DT Article DE GLUTAMATE; INOSITOL PHOSPHATES; DEVELOPMENT; PRIMARY CORTICAL CULTURES; NEURONS; ASTROCYTES ID AMINO-ACID RECEPTORS; PHOSPHOINOSITIDE HYDROLYSIS; MESSENGER-RNA; RAT-BRAIN; TURNOVER; PROFILE; CORTEX; CELLS AB It was the purpose of the present study to evaluate glutamate-stimulated phosphatidylinositol metabolism in primary mixed astrocyte/neuron and neuron-enriched cortical cultures through different stages of development in vitro. Glutamate (0-200 mu M) stimulated inositol phosphate accumulation in a concentration-dependent fashion at 6, 13 and 20 days in vitro. Pure astrocyte cultures exhibited glutamate-stimulated phosphatidylinositol hydrolysis only at high concentrations (100-400 mu M), indicating that these cells contribute little to the overall inositolphosphate accumulation measured in mixed neuronal cultures treated with low glutamate concentrations. Comparison of mixed neuronal cultures with and without antimitotic treatment revealed that increasing astrocyte number suppressed glutamate-stimulated responses, presumably via glutamate uptake. In contrast to previous reports, glutamate-stimulated inositol phosphate accumulation, when expressed as a function of cell number, increased with increasing days in vitro. RP WALTER REED ARMY MED CTR, WALTER REED ARMY INST RES, DEPT MED NEUROSCI, DIV NEUROPSYCHIAT, WASHINGTON, DC 20307 USA. OI DeCoster, Mark/0000-0002-1716-2028 NR 21 TC 18 Z9 18 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0736-5748 EI 1873-474X J9 INT J DEV NEUROSCI JI Int. J. Dev. Neurosci. PD JUN PY 1994 VL 12 IS 3 BP 227 EP 233 DI 10.1016/0736-5748(94)90044-2 PG 7 WC Developmental Biology; Neurosciences SC Developmental Biology; Neurosciences & Neurology GA NT678 UT WOS:A1994NT67800006 PM 7942095 ER PT J AU JOHNS, JP VERNALIS, MN KAREMAKER, JM LATHAM, RD AF JOHNS, JP VERNALIS, MN KAREMAKER, JM LATHAM, RD TI DOPPLER EVALUATION OF CARDIAC FILLING AND EJECTION PROPERTIES IN HUMANS DURING PARABOLIC FLIGHT SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE WEIGHTLESSNESS; MICROGRAVITY; VENOUS RETURN; FLUID SHIFTS ID ACUTE HEMODYNAMIC-RESPONSES; CENTRAL VENOUS-PRESSURE; FLOW VELOCITY; WEIGHTLESSNESS; SPACE AB The cardiac filling and ejection properties of seven normal human subjects were examined during microgravity created on a National Aeronautics and Space Administration aircraft during parabolic flight. Doppler echocardiography was used to measure intracardiac velocities in sitting and supine subjects during three phases of flight: hypergravity (phase I), early microgravity (phase III), and late microgravity (phase IV). Heart rate declined 6% (P < 0.001) and right ventricular inflow velocities rose (46%, early; 26%, mean; P < 0.01) between phase I and phases III or IV in the sitting position only. Peak left ventricular outflow velocities rose 12% and inflow velocities rose (13%, early; 20%, mean) between phases I and IV while subjects were in the supine position (P < 0.05). A 14% rise in early velocities alone was seen between phases I and IV while subjects were in the sitting position (P < 0.05). In subjects entering microgravity while sitting, right heart chambers can accept additional venous return. When microgravity was entered while subjects were supine, however, venous augmentation was not observed. Left heart filling was more prominently enhanced when microgravity was entered while subjects were supine, suggesting a shift of fluid within the pulmonary vasculature. C1 VET AFFAIRS MED CTR,RENO,NV 89520. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. UNIV AMSTERDAM,DEPT PHYSIOL,1105 AZ AMSTERDAM,NETHERLANDS. LAB AEROSP CARDIOVASC RES,BROOKS AFB,TX 78235. RP JOHNS, JP (reprint author), UNIV NEVADA,SCH MED,1000 LOCUST ST,RENO,NV 89520, USA. NR 14 TC 26 Z9 26 U1 0 U2 0 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 8750-7587 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD JUN PY 1994 VL 76 IS 6 BP 2621 EP 2626 PG 6 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA NR916 UT WOS:A1994NR91600050 PM 7928892 ER PT J AU WELLNER, RB PLESS, DD THOMPSON, WL AF WELLNER, RB PLESS, DD THOMPSON, WL TI CHARACTERIZATION OF 3'-AZIDO-3'-DEOXYTHYMIDINE INHIBITION OF RICIN AND PSEUDOMONAS EXOTOXIN-A TOXICITY IN CHO AND VERO CELLS SO JOURNAL OF CELLULAR PHYSIOLOGY LA English DT Article ID HAMSTER OVARY CELLS; BREFELDIN-A; DIPHTHERIA-TOXIN; ENDOCYTIC VESICLES; PROTEIN-SYNTHESIS; CYTO-TOXICITY; ACTIVE-SITE; MODECCIN; CYTOTOXICITY; ENHANCEMENT AB Ricin (RIC), modeccin (MOD), Pseudomonas exotoxin A (PE), and diphtheria toxin (DT) are protein toxins that enter cells by receptor-mediated endocytosis. After intracellular transport and membrane translocation to the cytosol, these toxins inhibit protein synthesis by enzymatically removing a specific adenine residue from ribosomal RNA (RIC, MOD), or by ADP-ribosylation of elongation factor-2 (PE, DT). Recently, Thompson and Pace (1992) reported that AZT (3'azido-3'-deoxythymidine) inhibited RIC toxicity in Vero cells, and this inhibition was not due to a block of RIC enzymatic activity. This paper extends these findings and examines the effects of AZT treatment on the toxicities of other protein toxins in Chinese hamster ovary (CHO) and Vero cell lines. AZT treatment did not significantly alter the toxicity of DT or MOD in either cell line, but it markedly reduced RIC and PE toxicity in both cell lines. The ID50 values (concentration of toxin required to inhibit protein synthesis by 50%) for RIC and PE in CHO cells increased approximately 6.5- and 12.5-fold, respectively; while in Vero cells the ID50 values increased ca. 8.5- and 4.5-fold, respectively. Results of further studies revealed differences in the mechanisms by which AZT inhibited RIC and PE toxicity. Results of cell-free translation indicated that, unlike its effects on RIC, AZT blocked the ability of PE to perform its enzymatic activity. As AZT did not block RIC enzymatic activity, we examined the effects of AZT on earlier steps in the RIC intoxication process. AZT treatment did not inhibit cell-surface binding or internalization of [I-125]-RIC. Results of kinetic studies showed that when AZT was incubated with cells at the time of RIC exposure, it caused no major change in the lag phase, during which RIC reaches the site of translocation. However, it clearly reduced the subsequent first-order reduction in the rate of protein synthesis, suggesting an effect on translocation. Monensin (an ionophore that perturbs intracellular trafficking and increases the toxicities of RIC and PE) reduced AZT protection against both toxins. Nocodazole and colchicine (agents that disrupt microtubules and some routes of intracellular trafficking) reduced the ability of AZT to inhibit RIC, but not PE, toxicity. In summary, our results suggest that (1) AZT acts within the cytosol to inhibit (directly or indirectly) the enzymatic action of PE, and (2) the AZT inhibition of RIC cytotoxicity does not involve perturbations of RIC cell-surface binding, internalization, or enzymatic activity but might result from an alteration in RIC translocation. (C) 1994 Wiley-Liss, Inc. RP WELLNER, RB (reprint author), USA,MED RES INST INFECT DIS,DIV TOXINOL,FREDERICK,MD 21702, USA. NR 39 TC 6 Z9 6 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0021-9541 J9 J CELL PHYSIOL JI J. Cell. Physiol. PD JUN PY 1994 VL 159 IS 3 BP 495 EP 505 DI 10.1002/jcp.1041590314 PG 11 WC Cell Biology; Physiology SC Cell Biology; Physiology GA NM399 UT WOS:A1994NM39900013 PM 8188764 ER PT J AU RICE, BM GARRETT, BC KOSZYKOWSKI, ML FOILES, SM DAW, MS AF RICE, BM GARRETT, BC KOSZYKOWSKI, ML FOILES, SM DAW, MS TI KINETIC ISOTOPE EFFECTS FOR HYDROGEN DIFFUSION IN BULK NICKEL AND ON NICKEL SURFACES (VOL 92, PG 775, 1990) SO JOURNAL OF CHEMICAL PHYSICS LA English DT Correction C1 PACIFIC NW LAB, RICHLAND, WA 99352 USA. SANDIA NATL LABS, LIVERMORE, CA 94551 USA. RP RICE, BM (reprint author), USA, RES LAB, ABERDEEN PROVING GROUND, MD 21005 USA. RI Garrett, Bruce/F-8516-2011 NR 1 TC 3 Z9 3 U1 0 U2 1 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-9606 J9 J CHEM PHYS JI J. Chem. Phys. PD JUN 1 PY 1994 VL 100 IS 11 BP 8556 EP 8556 DI 10.1063/1.467289 PG 1 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA NN731 UT WOS:A1994NN73100085 ER PT J AU BURCH, HB SELLITTI, D BARNES, SG NAGY, EV BAHN, RS BURMAN, KD AF BURCH, HB SELLITTI, D BARNES, SG NAGY, EV BAHN, RS BURMAN, KD TI THYROTROPIN RECEPTOR ANTISERA FOR THE DETECTION OF IMMUNOREACTIVE PROTEIN SPECIES IN RETROOCULAR FIBROBLASTS OBTAINED FROM PATIENTS WITH GRAVES OPHTHALMOPATHY SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM LA English DT Article ID RETRO-ORBITAL TISSUE; ENDOCRINE OPHTHALMOPATHY; MESSENGER-RNA; ANTIBODIES; EXPRESSION; IMMUNOGLOBULINS; LYMPHOCYTES; INVITRO; CELLS; SERA AB Autoimmunity against the TSH receptor (hTSH-R) is known to be the proximate cause of thyroidal activation in Graves' disease, but has not been definitively linked to extrathyroidal manifestations of this disorder, such as ophthalmopathy and pretibial myxedema. In an effort to increase our knowledge concerning mechanisms responsible for Graves' ophthalmopathy, we used antiserum directed against a highly immunogenic portion of the hTSH-R (amino acids 352-367; P1) to assess the presence of this receptor or immunologically related protein in cultured human retroocular fibroblasts obtained from patients with Graves' ophthalmopathy. Immunoenzymatic and immunofluorescent studies revealed specific staining of both cytoplasmic and cell membrane-associated protein in discrete vesicles. To further evaluate the immunoreactive species present in these cells, immunoblotting experiments were performed using hTSH-R-specific antisera (anti-P1) and sera obtained from patients with Graves' disease. Several protein bands were identified using both anti-P1 and Graves' disease patient sera, including species at mol wt of 95, 71, and 18 kilodaltons, the possible significance of which is discussed. The results support the hypothesis that immunity against the hTSH-R or related proteins contributes to the ophthalmopathy of Graves' disease. C1 UNIFORMED SERV UNIV HLTH SCI, DEPT MED, BETHESDA, MD 20814 USA. MAYO CLIN & MAYO FDN, DIV ENDOCRINOL, ROCHESTER, MN 55905 USA. RP BURCH, HB (reprint author), WALTER REED ARMY MED CTR, ENDOCRINE METAB SERV, KYLE METAB UNIT, WASHINGTON, DC 20307 USA. FU FIC NIH HHS [1-F05-TW04412-01] NR 33 TC 44 Z9 51 U1 0 U2 0 PU ENDOCRINE SOC PI CHEVY CHASE PA 8401 CONNECTICUT AVE, SUITE 900, CHEVY CHASE, MD 20815-5817 USA SN 0021-972X J9 J CLIN ENDOCR METAB JI J. Clin. Endocrinol. Metab. PD JUN PY 1994 VL 78 IS 6 BP 1384 EP 1391 DI 10.1210/jc.78.6.1384 PG 8 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA NQ265 UT WOS:A1994NQ26500020 PM 8200941 ER PT J AU UHAA, IJ FISHBEIN, DB OLSON, JG RIVES, CC WAAG, DM WILLIAMS, JC AF UHAA, IJ FISHBEIN, DB OLSON, JG RIVES, CC WAAG, DM WILLIAMS, JC TI EVALUATION OF SPECIFICITY OF INDIRECT ENZYME-LINKED-IMMUNOSORBENT-ASSAY FOR DIAGNOSIS OF HUMAN Q-FEVER SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID HEAT-SHOCK PROTEINS; INDIRECT FLUORESCENT-ANTIBODY; COXIELLA-BURNETII; COMPLEMENT-FIXATION; ESCHERICHIA-COLI; PHASE-I; IMMUNOGLOBULIN RESPONSES; SEROLOGICAL DIAGNOSIS; IMMUNE-RESPONSE; UNITED-STATES AB Ninety-five acute- and convalescent-phase serum specimens from 48 patients suspected of having rickettsial or Legionella infections were assayed for antibodies to Coxiella burnetii, the causative agent of Q fever. To evaluate the specificity of the indirect enzyme-linked immunosorbent assay (ELISA) for human Q fever, we compared the ELISA results with those of the indirect immunofluorescence antibody (IFA) test. The ELISA data were analyzed by two different criteria for a positive test. The first criterion for positive results by ELISA was based upon diagnostic titers established in a study of 150 subjects who had no demonstrable cellular or humoral immune responses to C. burnetii phase I or phase II whole cells or phase I lipopolysaccharide. The second criterion was based upon diagnostic antibody titers in a study of 51 subjects who had been diagnosed as having clinical Q fever and had fourfold or greater rises in humoral immune responses to C. burnetii phase I and phase II whole-cell antigens. A comparison of the ELISA and IFA test results of the 95 serum specimens indicated excellent agreement between the tests (Kappa = 92.9%; P < 0.05). None of the 38 patients whose etiologies were confirmed serologically as Legionnaires' disease or rickettsial diseases other than Q fever were classified as positive for C. burnetii by the ELISA. Only one patient identified by the IFA test as having Q fever was not scored positive by the ELISA. These results suggest that the ELISA is useful for epidemiologic screening and as a diagnostic test for human Q fever. C1 US PHS,CTR DIS CONTROL & PREVENT,NATL CTR INFECT DIS,DIV VIRAL & RICKETTSIAL DIS,ATLANTA,GA 30333. US PHS,CTR DIS CONTROL & PREVENT,EPIDEMIOL PROGRAM OFF,DIV FIELD EPIDEMIOL,INT BRANCH,ATLANTA,GA 30333. USA,MED RES INST INFECT DIS,DIV BACTERIOL,PATHOGENESIS & IMMUNOL BRANCH,FREDERICK,MD 21702. US FDA,CTR BIOL EVALUAT & RES,DIV VACCINE & RELATED PROD APPLICAT,OFF VACCINE RES & REVIEW,ROCKVILLE,MD 20852. NR 47 TC 26 Z9 26 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD JUN PY 1994 VL 32 IS 6 BP 1560 EP 1565 PG 6 WC Microbiology SC Microbiology GA NL918 UT WOS:A1994NL91800027 PM 8077404 ER PT J AU BOEDEKER, BH LOJESKI, EW KLINE, MD HAYNES, DH AF BOEDEKER, BH LOJESKI, EW KLINE, MD HAYNES, DH TI ULTRA-LONG-DURATION LOCAL-ANESTHESIA PRODUCED BY INJECTION OF LECITHIN-COATED TETRACAINE MICROCRYSTALS SO JOURNAL OF CLINICAL PHARMACOLOGY LA English DT Article; Proceedings Paper CT 12th Frontiers of Clinical Pharmacology Symposium, Pharmacology Beyond Earths Boundaries CY MAY 06-08, 1992 CL HOUSTON, TX ID METHOXYFLURANE; MICRODROPLETS AB This study was designed to determine if microencapsulated tetracaine would provide a longer duration of local anesthesia than nonmicroencapsulated (neat) tetracaine. Local anesthesia was determined by monitoring the response of the rat to tail clamping after the installation of a subcutaneous ring block. Ten percent microencapsulated tetracaine was found to provide local anesthesia of the tail for a 43-hour duration. Ten percent tetracaine solution was toxic. One percent tetracaine solution provided a tail block lasting 8 hours. Lecithin membranes without drug provided no block. This study demonstrates that lecithin-coated tetracaine microcrystals produce a local anesthetic effect that is ultra-long in duration, reversible, and not systemically toxic. C1 WALTER REED ARMY MED CTR,DEPT ANESTHESIOL,WASHINGTON,DC 20307. NR 6 TC 17 Z9 17 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0091-2700 J9 J CLIN PHARMACOL JI J. Clin. Pharmacol. PD JUN PY 1994 VL 34 IS 6 BP 699 EP 702 PG 4 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA NQ189 UT WOS:A1994NQ18900022 PM 8083403 ER PT J AU VICK, JA AF VICK, JA TI MEDICAL STUDIES OF POISONOUS LAND AND SEA-SNAKES SO JOURNAL OF CLINICAL PHARMACOLOGY LA English DT Article; Proceedings Paper CT 12th Frontiers of Clinical Pharmacology Symposium, Pharmacology Beyond Earths Boundaries CY MAY 06-08, 1992 CL HOUSTON, TX AB The comparative toxicity and pathophysiology of thirteen (13) of poisonous snakes indigenous to the area in and around Saudi Arabia were determined. Four snakes from the Viperidae family, six from the Elapidae family, and three representative sea snakes from the family Hydrophiodae were included. Anesthetized adult Beagle dogs and anesthetized monkeys were used in the study. Vital physiologic functions were recorded continuously as were changes in the blood coagulation system and any tissue damage produced by the venom at the site of envenomation. venom was administered intravenously or by an actual bite. Venom from the snakes of the family Viperidae produced death in an average of 3 hours. The average lethal dose was 1.13 mg/kg. Depression of 1st and 2nd stage clotting factors and a decrease in fibrinogen levels and in platelet counts were observed with these venoms. Findings suggestive of intravascular coagulation also were observed with moderate hemolysis of the formed elements. Some local hemorrhage was seen at the site of envenomation. venom from the Elapidae family of snakes produced death at an average of 1.7 hours. The average lethal dose was 0.70 mg/kg. Death appeared to be primarily due to respiratory paralysis after blockade at the neuromuscular junction. Only moderate hemolysis was seen with these venoms. No intravascular coagulation or tissue damage was seen. The venom of the family Hydrophiodae consistently produced death in less than 30 minutes at an average dose of 0.06 mg/kg. Tissue damage was not observed, and changes were not observed in the hematologic parameters monitored. Death in these studies was due primarily to respiratory paralysis; however, the breakdown of muscle tissue was observed. The area in and around Saudi Arabia has a number of snakes that are dangerous to humans. C1 WALTER REED ARMY INST RES,WASHINGTON,DC. RP VICK, JA (reprint author), US FDA,200 C ST SW,WASHINGTON,DC 20204, USA. NR 9 TC 5 Z9 5 U1 0 U2 2 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0091-2700 J9 J CLIN PHARMACOL JI J. Clin. Pharmacol. PD JUN PY 1994 VL 34 IS 6 BP 709 EP 712 PG 4 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA NQ189 UT WOS:A1994NQ18900024 PM 8083405 ER PT J AU CIALONE, MA AF CIALONE, MA TI THE COASTAL MODELING SYSTEM (CMS) - A COASTAL PROCESSES SOFTWARE PACKAGE SO JOURNAL OF COASTAL RESEARCH LA English DT Article DE COASTAL PROCESSES; LONG-WAVE HYDRODYNAMICS; SEDIMENT TRANSPORT; WAVE PROPAGATION; WAVE TRANSFORMATION; TROPICAL STORM; EXTRATROPICAL STORM; HARBOR OSCILLATION; NUMERICAL MODELING; COMPUTER PROGRAM AB The Coastal Modeling System (CMS) is a software package that organizes the Coastal Engineering Research Center's (CERC) larger numerical models and their supporting software into a useable system. The CMS includes time-dependent and time-independent long-wave hydrodynamics models, short-wave models, wind models, and sediment transport models. Since some of the models share similar input requirements and output capabilities, these portions of the models are standardized as much as possible. This standardization promotes efficiency because coding effort is reduced, new users learn the models in the system more rapidly, and chances for errors in entering input or interpreting output are reduced because of user familiarity with the system structure. Important factors which were addressed during system development included: maintenance of a single version of each model, standardization of the model input/output processes, selection of a central location where models reside, inclusion of versatile models with options for simulating a wide range of problems at different sites, and preparation of comprehensive model documentation in the form of a user's manual. RP CIALONE, MA (reprint author), USA,ENGINEER WATERWAYS EXPT STN,COASTAL ENGN RES CTR,VICKSBURG,MS 39180, USA. NR 24 TC 4 Z9 4 U1 0 U2 0 PU COASTAL EDUCATION & RESEARCH FOUNDATION PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 SN 0749-0208 J9 J COASTAL RES JI J. Coast. Res. PD SUM PY 1994 VL 10 IS 3 BP 576 EP 587 PG 12 WC Environmental Sciences; Geography, Physical; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Physical Geography; Geology GA NU689 UT WOS:A1994NU68900005 ER PT J AU THOMPSON, EF LEENKNECHT, DA AF THOMPSON, EF LEENKNECHT, DA TI WIND ESTIMATION FOR COASTAL MODELING APPLICATIONS SO JOURNAL OF COASTAL RESEARCH LA English DT Article DE COASTAL ENGINEERING; HURRICANES; NUMERICAL MODELING; SURFACE WINDS; COMPUTER PROGRAMS ID PREDICTION; LANDFALL AB Winds near the water surface are influenced by a variety of physical processes ranging from synaptic scale variations in atmospheric pressure to very localized interactions with coastal landforms. The U.S. Army Corps of Engineers (CE) requires wind information for estimating waves, water levels, and circulations at coastal locations varying from small reservoirs to the ocean shore. The broad scope of natural processes affecting winds over water and the present CE estimation procedures are reviewed. C1 USA,ENGINEER WATERWAYS EXPT STN,COASTAL ENGN RES CTR,VICKSBURG,MS 39180. USA,ENGINEER WATERWAYS EXPT STN,COASTAL RES PROGRAM,COASTAL ENGN RES CTR,VICKSBURG,MS 39180. RP THOMPSON, EF (reprint author), USA,ENGINEER WATERWAYS EXPT STN,COASTAL ENGN RES CTR,CEWES CRO,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 23 TC 5 Z9 5 U1 0 U2 0 PU COASTAL EDUCATION & RESEARCH FOUNDATION PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 SN 0749-0208 J9 J COASTAL RES JI J. Coast. Res. PD SUM PY 1994 VL 10 IS 3 BP 628 EP 636 PG 9 WC Environmental Sciences; Geography, Physical; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Physical Geography; Geology GA NU689 UT WOS:A1994NU68900009 ER PT J AU LYON, JG WILLIAMS, DC FLANNIGAN, KG AF LYON, JG WILLIAMS, DC FLANNIGAN, KG TI EFFECTS OF COMMERCIAL VESSEL PASSAGE IN NARROW CHANNELS WITH AND WITHOUT ICE COVER SO JOURNAL OF COLD REGIONS ENGINEERING LA English DT Article ID ST-MARYS RIVER; MICHIGAN AB Two different models were used to simulate the influence of commercial vessels transiting narrow-cross-sectional channels in the presence and absence of ice. Models were developed by two contracted groups using hydraulic principles. These models were calibrated for local conditions using measurements of effects of vessel passage conducted during the ice-on and open-water navigation seasons. Results of model simulations compared well with verification data from vessel passages. Model simulations provided valuable information to assess potential impacts of navigation during ice-on periods. C1 USA,CORPS ENGRS,N CENT DIV,POLICY & LONG RANGE PLNNG BRANCH,CHICAGO,IL 60606. BALLEAU GROUNDWATER,ALBUQUERQUE,NM 87102. RP LYON, JG (reprint author), OHIO STATE UNIV,DEPT CIVIL ENGN,COLUMBUS,OH 43210, USA. NR 17 TC 0 Z9 0 U1 0 U2 1 PU ASCE-AMER SOC CIVIL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0887-381X J9 J COLD REG ENG JI J. Cold Reg. Eng. PD JUN PY 1994 VL 8 IS 2 BP 47 EP 64 DI 10.1061/(ASCE)0887-381X(1994)8:2(47) PG 18 WC Engineering, Environmental; Engineering, Civil; Geosciences, Multidisciplinary SC Engineering; Geology GA QA985 UT WOS:A1994QA98500002 ER PT J AU FARID, F KONING, TL AF FARID, F KONING, TL TI SIMULATION VERIFIES QUEUING PROGRAM FOR SELECTING LOADER-TRUCK FLEETS SO JOURNAL OF CONSTRUCTION ENGINEERING AND MANAGEMENT-ASCE LA English DT Article AB Proper equipment selection can yield substantial savings in ti- and cost. MicroCYCLONE simulation package is used to verify the FLEET queuing program. FLEET models multiloader-truck systems using exponential distribution at steady state. A few FLEET assumptions are redefined to closely model real-world construction processes. Graphical solutions illustrate effects of the cycle-time modeling and transient state on multiloader-truck fleet selection. FLEET is shown to be an accurate model of the steady-state, multiloader-truck process if exponential distribution did accurately fit load- and travel-time distributions. But, erlang of beta distribution more closely fits actual load and travel times in construction. Modeling load and travel times of loader-truck fleets with exponential, instead of beta, distribution results in underestimation of production and overestimation of unit cost by 4-7%. Simulation results of a more accurate model that uses beta distribution and considers transient state, in addition to steady state, indicate that multiloader-truck fleets may experience a 4-5% production increase and unit-cost decrease compared to FLEET results. C1 US MIL ACAD,W POINT,NY 10996. NR 0 TC 32 Z9 32 U1 0 U2 0 PU ASCE-AMER SOC CIVIL ENGINEERS PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-9364 J9 J CONSTR ENG M ASCE JI J. Constr. Eng. Manage.-ASCE PD JUN PY 1994 VL 120 IS 2 BP 386 EP 404 DI 10.1061/(ASCE)0733-9364(1994)120:2(386) PG 19 WC Construction & Building Technology; Engineering, Industrial; Engineering, Civil SC Construction & Building Technology; Engineering GA NM250 UT WOS:A1994NM25000011 ER PT J AU MENGISTU, M LUKES, YG NAGY, EV BURCH, HB CARR, FE LAHIRI, S BURMAN, KD AF MENGISTU, M LUKES, YG NAGY, EV BURCH, HB CARR, FE LAHIRI, S BURMAN, KD TI TSH RECEPTOR GENE-EXPRESSION IN RETROOCULAR FIBROBLASTS SO JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION LA English DT Article DE TSH RECEPTOR; GENE; RETROOCULAR; FIBROBLASTS; THYROID ID THYROTROPIN-RECEPTOR; MOLECULAR-CLONING; GRAVES OPHTHALMOPATHY; MESSENGER-RNA; DISEASE; MUSCLE AB RNA was isolated from fibroblasts from the retroocular area, from endomysial fibroblasts obtained from orbital lateral rectus muscle, and from abdominal skin fibroblasts. The RNA was reverse transcribed into cDNA which was then used as a template for PCR with primers encompassing a portion (nucleotides 989-1235) of the extra-cellular domain of the human TSH receptor (hTSH-R). A definite 247 BP product was detected from fibroblast RNA by ethidium bromide staining, and was confirmed by hybridization with labelled hTSH-R cDNA. The product had homology with the known TSH-R cDNA. These studies indicate that human fibroblasts can express hTSH-R, and they suggest that a cross reactive immunologic response between anti-hTSH-R and these fibroblast TSH receptors may play a role in the genesis of Graves' ophthalmopathy. C1 WALTER REED ARMY MED CTR,DEPT MED,ENDOCRINE METAB SERV,KYLE METAB UNIT,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT CLIN INVEST,ENDOCRINE METAB SERV,KYLE METAB UNIT,WASHINGTON,DC 20307. GEORGETOWN UNIV,MED CTR,DEPT MED,WASHINGTON,DC 20007. FU FIC NIH HHS [1F05 TWO 4412] NR 16 TC 57 Z9 58 U1 0 U2 2 PU EDITRICE KURTIS S R L PI MILANO PA VIA LUIGI ZOJA, 30-20153 MILANO, ITALY SN 0391-4097 J9 J ENDOCRINOL INVEST JI J. Endocrinol. Invest. PD JUN PY 1994 VL 17 IS 6 BP 437 EP 441 PG 5 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA NU988 UT WOS:A1994NU98800008 PM 7523481 ER PT J AU NAGHSKI, DH BOYD, JT JACKSON, HE SRIRAM, S KINGSLEY, SA LATESS, J AF NAGHSKI, DH BOYD, JT JACKSON, HE SRIRAM, S KINGSLEY, SA LATESS, J TI AN INTEGRATED PHOTONIC MACH-ZEHNDER INTERFEROMETER WITH NO ELECTRODES FOR SENSING ELECTRIC-FIELDS SO JOURNAL OF LIGHTWAVE TECHNOLOGY LA English DT Article ID DOMAIN INVERSION; LITHIUM-NIOBATE; OPTICAL-DEVICES; PROTON-EXCHANGE; LINBO3; WAVEGUIDES; SLAB AB A new configuration for a Mach-Zehnder interferometric electric field sensor device utilizing the electrooptic effect is reported. The lithium niobate device uses no metallic electrodes and operates solely by immersion in an electric field. Reverse poling of one arm of the interferometer provides opposing optical phase changes in the two interferometer arms when placed in an electric field. One fabricated device exhibits a measured minimum detectable field of 0.22 V/m square-root Hz and a frequency response of greater than 1 GHz. Theoretical calculations show that detection of 0.11 V/m square-root Hz is attainable while the upper frequency limit can exceed 6 GHz. C1 UNIV CINCINNATI,DEPT PHYS,CINCINNATI,OH 45221. SRICO INC,POWELL,OH 43065. USA,RES LAB,ELECTROMAGNET PULSE PHYS BRANCH,ADELPHI,MD 20783. RP NAGHSKI, DH (reprint author), UNIV CINCINNATI,DEPT ELECT & COMP ENGN,CINCINNATI,OH 45221, USA. RI Jackson, Howard/K-4881-2012 NR 29 TC 43 Z9 45 U1 1 U2 5 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0733-8724 J9 J LIGHTWAVE TECHNOL JI J. Lightwave Technol. PD JUN PY 1994 VL 12 IS 6 BP 1092 EP 1098 DI 10.1109/50.296204 PG 7 WC Engineering, Electrical & Electronic; Optics; Telecommunications SC Engineering; Optics; Telecommunications GA NZ743 UT WOS:A1994NZ74300026 ER PT J AU KATIAL, R HONEYCUTT, W OSWALD, SG AF KATIAL, R HONEYCUTT, W OSWALD, SG TI PNEUMOCYSTIS-CARINII PNEUMONIA PRESENTING AS FOCAL BIBASILAR UPTAKE ON GALLIUM SCAN DURING AEROSOLIZED PENTAMIDINE PROPHYLAXIS SO JOURNAL OF NUCLEAR MEDICINE LA English DT Note DE PNEUMOCYSTIS CARINII PNEUMONIA; GALLIUM SCAN; AEROSOLIZED PENTAMIDINE ID ACQUIRED-IMMUNODEFICIENCY-SYNDROME; IMMUNE-DEFICIENCY-SYNDROME; INHALED PENTAMIDINE; GA-67 SCINTIGRAPHY; PATIENT; DIAGNOSIS; PATTERNS; CHEST AB Radionuclide imaging with gallium is commonly performed in the evaluation of patients with suspected Pneumocystis carinii pneumonia (PCP) and is known to be highly sensitive for detection of PCP. We present a patient with acquired immunodeficiency who developed PCP in the bases of both lungs while on aerosolized pentamidine prophylaxis. A gallium scan demonstrated focal uptake in the lung bases, a pattern generally not associated with PCP, and was extremely useful in guiding bronchoscopy. An aerosol ventilation scan performed after complete resolution of the clinical illness demonstrated prominent ventilatory defects in the lung bases corresponding to the regions of previous gallium uptake. We speculate that the underlying ventilatory abnormality may have contributed to poor drug delivery to the lung bases. Pneumocystis carinii pneumonia must be considered with any focal area of gallium accumulation in patients receiving aerosolized pentamidine. C1 DWIGHT D EISENHOWER ARMY MED CTR,DEPT RADIOL,NUCL MED SERV,FT GORDON,GA. DWIGHT D EISENHOWER ARMY MED CTR,DEPT MED,FT GORDON,GA. NR 17 TC 2 Z9 2 U1 0 U2 0 PU SOC NUCLEAR MEDICINE INC PI RESTON PA 1850 SAMUEL MORSE DR, RESTON, VA 20190-5316 SN 0161-5505 J9 J NUCL MED JI J. Nucl. Med. PD JUN PY 1994 VL 35 IS 6 BP 1038 EP 1040 PG 3 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA NP288 UT WOS:A1994NP28800022 PM 8195865 ER PT J AU MARTIN, SK JETT, M SCHNEIDER, I AF MARTIN, SK JETT, M SCHNEIDER, I TI CORRELATION OF PHOSPHOINOSITIDE HYDROLYSIS WITH EXFLAGELLATION IN THE MALARIA MICROGAMETOCYTE SO JOURNAL OF PARASITOLOGY LA English DT Article ID INOSITOL 1,3,4,5-TETRAKISPHOSPHATE; PLASMODIUM-FALCIPARUM; 2ND MESSENGERS; METABOLISM; PHOSPHATES; RELEASE; CELLS AB Cellular responses to growth factors, hormones, and other agonists have been shown in many animal cell systems to be mediated by the signal transduction cascade controlled by phospholipase C. One such response, calcium mobilization, is regulated by the concerted effect of several specific inositol (poly)phosphates. Another response, protein phosphorylation, is regulated by other phospholipase C (PLC) hydrolysis products. Mature gametocytes are specialized cells primed for transformation into gametes immediately upon removal from the vertebrate bloodstream, thereby initiating the sexual cycle in a vector mosquito. This study showed that PLC hydrolysis products, inositol (1,4,5)triphosphate and diacylglycerol, are correlated with the initial events of flagellar development; they are implicated in synchronizing this crucial transformation for the parasite and hence the continued transmission of the parasite, which leads to this debilitating disease. C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT MOLEC PATHOL,WASHINGTON,DC 20307. NR 26 TC 37 Z9 38 U1 0 U2 1 PU AMER SOC PARASITOLOGISTS PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 SN 0022-3395 J9 J PARASITOL JI J. Parasitol. PD JUN PY 1994 VL 80 IS 3 BP 371 EP 378 DI 10.2307/3283406 PG 8 WC Parasitology SC Parasitology GA NQ742 UT WOS:A1994NQ74200005 PM 8195938 ER PT J AU TAYLOR, RN NESBITT, RW VIDAL, P HARMON, RS AUVRAY, B CROUDACE, IW AF TAYLOR, RN NESBITT, RW VIDAL, P HARMON, RS AUVRAY, B CROUDACE, IW TI MINERALOGY, CHEMISTRY, AND GENESIS OF THE BONINITE SERIES VOLCANICS, CHICHIJIMA, BONIN-ISLANDS, JAPAN SO JOURNAL OF PETROLOGY LA English DT Article ID STABLE ISOTOPE COMPOSITIONS; NORTHERN MARIANA-ISLANDS; OCEAN-RIDGE BASALTS; RARE-EARTH ELEMENT; WESTERN PACIFIC; TRACE-ELEMENT; SUBDUCTED LITHOSPHERE; TROODOS OPHIOLITE; ARC VOLCANICS; NEW-CALEDONIA AB The Bonin archipelago represents an uplifted fore-arc terrain which exposes the products of Eocene supra-subduction zone magmatism. Chichijima, at the centre of the chain, represents the type locality for the high-Mg andesitic lava termed boninite. The range of extrusives which constitute the boninite series volcanics are present on Chichijima, and are disposed in the sequence boninite-andesite-dacite with increasing height in the volcano-stratigraphy. Progression to evolved compositions within the Chichijima boninite series is controlled by crystal fractionation from a boninite parental magma containing approximately 15% MgO. Olivine and clinoenstatite are the initial liquidus phases, but extraction of enstatitic orthopyroxene, followed by clinopyroxene and plagioclase, is responsible for the general evolution from boninite, through andesite. to dacite. Some andesites within the overlying Mikazukiyama Formation are petrographically distinct from the main boninite series in containing magnetite phenocrysts and a high proportion of plagioclase. As such, these andesites have affinities with the calc-alkaline series. Major and trace element data for 74 boninitic series rocks from Chichijima are presented. Although major element variation is dominantly controlled by high-level crystal fractionation, the large variations in incompatible trace element concentrations at high MgO compositions cannot be explained by this mechanism. Nd, Pb, and Sr isotopic data indicate the following: (1) a strong overprint on Sr-87/Sr-86 by seawater alteration; (2) Pb isotopes lie above the northern hemisphere reference line (NHRL) and are thus similar to the <30-Ma arc and basin lavas of the Izu-Bonin system, and (3) epsilon(Nd)(40 Ma) ranges between 2.8 and 6.8 within the boninite series volcanics. Differences in rare-earth elements (REE), Zr, Ti, and Nd-143/Nd-144 at similar degrees of fractionation can be explained by the addition of a component of fixed composition from the down-going oceanic crustal slab to a variably depleted source region within the overlying wedge. Data presented for Sm/Zr and Ti/Zr indicate that boninite series volcanics are characterized by low values for both of these ratios. In particular, boninites appear to have uniquely low Sm/Zr ratios. These characteristics may be the result of slab melting in the presence of residual amphibole; the resultant melt could combine with typical slab dehydration fluids and infiltrate the overlying mantle wedge. Such a fluid melt component could mix either with shallow mantle or directly with primitive melts from depleted mantle. Trace elements, REE, and isotope data thus point to a model for boninite genesis which requires tightly constrained pressure-temperature conditions in the slab combined with melting of a variably depleted source in the overlying wedge. Such constraints are rarely met except during the subduction of juvenile oceanic crust beneath a young, hot overriding plate. C1 USA,RES OFF,RES TRIANGLE PK,NC 27709. UNIV CLERMONT FERRAND,CNRS,UNITE 10,CLERMONT FERRAND,FRANCE. UNIV RENNES 1,CAESS,F-35042 RENNES,FRANCE. RP TAYLOR, RN (reprint author), UNIV SOUTHAMPTON,DEPT GEOL,SOUTHAMPTON SO9 5NH,HANTS,ENGLAND. RI Taylor, Rex/E-3716-2012; OI Taylor, Rex/0000-0002-9367-0294; Croudace, Ian/0000-0003-1547-5650 NR 87 TC 131 Z9 134 U1 3 U2 30 PU OXFORD UNIV PRESS UNITED KINGDOM PI OXFORD PA WALTON ST JOURNALS DEPT, OXFORD, ENGLAND OX2 6DP SN 0022-3530 J9 J PETROL JI J. Petrol. PD JUN PY 1994 VL 35 IS 3 BP 577 EP 617 PG 41 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA NW512 UT WOS:A1994NW51200001 ER PT J AU DAI, WL WOODWARD, PR AF DAI, WL WOODWARD, PR TI STRUCTURES OF RECONNECTION LAYERS BASED ON THE IDEAL MAGNETOHYDRODYNAMIC EQUATIONS SO JOURNAL OF PLASMA PHYSICS LA English DT Article ID INTERMEDIATE SHOCKS; SCHEME AB A Riemann solver is used, and a set of numerical simulations are performed, to study the structures of reconnection layers in the approximation of the one-dimensional ideal MHD equations. Since the Riemann solver may solve general Riemann problems, the model used in this paper is more general than those in previous investigations on this problem. Under the conditions used in the previous investigations, the structures we obtained are the same. Our numerical simulations show quantitative agreement with those obtained through the Riemann solver. RP DAI, WL (reprint author), UNIV MINNESOTA,ARMY HIGH PERFORMANCE COMP RES CTR,1100 WASHINGTON AVE S,MINNEAPOLIS,MN 55415, USA. NR 20 TC 0 Z9 0 U1 0 U2 0 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 40 WEST 20TH STREET, NEW YORK, NY 10011-4211 SN 0022-3778 J9 J PLASMA PHYS JI J. Plasma Phys. PD JUN PY 1994 VL 51 BP 381 EP 398 PN 3 PG 18 WC Physics, Fluids & Plasmas SC Physics GA PK709 UT WOS:A1994PK70900003 ER PT J AU DEITCH, AK BAILEY, DK AF DEITCH, AK BAILEY, DK TI CONDYLAR ELEMENT MODIFICATION OF A SEMIADJUSTABLE ARTICULATOR - FLAT CONDYLAR PATH TO CURVED CONDYLAR PATH SO JOURNAL OF PROSTHETIC DENTISTRY LA English DT Article C1 USA,DENT ACT,FT BENNING,GA 31905. NR 0 TC 0 Z9 0 U1 0 U2 2 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0022-3913 J9 J PROSTHET DENT JI J. Prosthet. Dent. PD JUN PY 1994 VL 71 IS 6 BP 649 EP 649 DI 10.1016/0022-3913(94)90453-7 PG 1 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA NP004 UT WOS:A1994NP00400019 PM 8040832 ER PT J AU JOHNSON, WB DEVRIES, R RIDLEY, CR PETTORINI, D PETERSON, DR AF JOHNSON, WB DEVRIES, R RIDLEY, CR PETTORINI, D PETERSON, DR TI THE COMPARATIVE EFFICACY OF CHRISTIAN AND SECULAR RATIONAL-EMOTIVE THERAPY WITH CHRISTIAN CLIENTS SO JOURNAL OF PSYCHOLOGY AND THEOLOGY LA English DT Article ID PSYCHOTHERAPY OUTCOME RESEARCH; COGNITIVE-BEHAVIOR-THERAPY; COUNSELORS TREATMENT PLANS; RELIGIOUS INDIVIDUALS; CLINICAL DEPRESSION; MENTAL-HEALTH; VALUES; ISSUES; EXPERIENCE; VALIDITY AB The present study utilized a comparative psychotherapy outcome design to evaluate the relative therapeutic efficacy of Christian and secular RET with depressed Christian clients. Results showed both treatments significantly reduced depression, automatic negative thinking, irrational thinking, and general pathology. These gains were maintained after three months. There were no significant differential treatment effects. Results are discussed in terms of the implications for accommodation theory. C1 FULLER THEOL SEMINARY,GRAD SCH PSYCHOL,PASADENA,CA 91101. INDIANA UNIV,BLOOMINGTON,IN 47401. TRIPLER ARMY MED CTR,HONOLULU,HI 96859. RP JOHNSON, WB (reprint author), USN,MED CLIN,DEPT MENTAL HLTH,BOX 121,HONOLULU,HI 96860, USA. NR 71 TC 32 Z9 32 U1 1 U2 12 PU ROSEMEAD SCHOOL PSYCHOLOGY PI LA MIRADA PA 13800 BIOLA AVENUE, BIOLA UNIVERSITY, LA MIRADA, CA 90639-0001 SN 0091-6471 J9 J PSYCHOL THEOL JI J. Psychol. Theol. PD SUM PY 1994 VL 22 IS 2 BP 130 EP 140 PG 11 WC Psychology, Multidisciplinary; Religion SC Psychology; Religion GA NU685 UT WOS:A1994NU68500006 ER PT J AU MULHERN, DW WATKINS, MA JENKINS, MA SHERROD, SK AF MULHERN, DW WATKINS, MA JENKINS, MA SHERROD, SK TI SUCCESSFUL NESTING BY A PAIR OF BALD EAGLES AT AGES 3 AND 4 SO JOURNAL OF RAPTOR RESEARCH LA English DT Note DE BALD EAGLES; KANSAS; NESTING; PLUMAGE; SUBADULT C1 USA,CORPS ENGINEERS,NAT RESOURCES MANAGEMENT BRANCH,KANSAS CITY,MO 64106. GM SUTTON AVIAN RES CTR INC,BARTLESVILLE,OK 74005. RP MULHERN, DW (reprint author), US FISH & WILDLIFE SERV,315 HOUSTON ST,SUITE E,MANHATTAN,KS 66502, USA. NR 14 TC 4 Z9 4 U1 1 U2 3 PU RAPTOR RESEARCH FOUNDATION INC PI HASTINGS PA 12805 ST CROIX TRAIL, HASTINGS, MN 55033 SN 0892-1016 J9 J RAPTOR RES JI J. Raptor Res. PD JUN PY 1994 VL 28 IS 2 BP 113 EP 114 PG 2 WC Ornithology SC Zoology GA PB284 UT WOS:A1994PB28400008 ER PT J AU LEGGETT, DC AF LEGGETT, DC TI H-BOND ACIDITY OF SOLVENTS .2. TRANSFORAMTION OF THE SNYDER CHI PROTON DONOR SCALE TO THE TAFT-KAMLET ALPHA-SCALE SO JOURNAL OF SOLUTION CHEMISTRY LA English DT Article DE SOLVENT ACIDITY; ALPHA(ALPHA)-LINEAR SOLVATION ENERGY RELATIONSHIPS (LSER); SOLVENT COHESION; SOLUBILITY PARAMETERS ID SOLVATION ENERGY RELATIONSHIPS; WATER PARTITION-COEFFICIENTS; SOLUTES; EQUATION AB By including a solvent cohesion term it was possible to transform Snyder's chi(d) scale into the Taft-Kamlet alpha scale for aliphatic H-bonding solvents The transforming equation was: alpha = 2.386chi(d) + 1.271alphabeta - 0.482 where alphabeta is the product of solvent acidity and basicity. Alpha is estimated for several solvents previously not thought to posses H-donor ability. These are dimethyl sulfoxide, nitroethane, dimethylformamide, dioxane, dimethylacetamide, propylene carbonate, ethyl acetate, butyrolactone, N-methylpyrrolidinone, and cyclohexanone. RP LEGGETT, DC (reprint author), DEPT ARMY,COLD REG RES & ENGN LAB,CORPS ENGN,HANOVER,NH 03755, USA. NR 9 TC 4 Z9 4 U1 1 U2 3 PU PLENUM PUBL CORP PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 SN 0095-9782 J9 J SOLUTION CHEM JI J. Solut. Chem. PD JUN PY 1994 VL 23 IS 6 BP 697 EP 701 DI 10.1007/BF00972715 PG 5 WC Chemistry, Physical SC Chemistry GA NT469 UT WOS:A1994NT46900004 ER PT J AU COLBECK, SC AF COLBECK, SC TI A REVIEW OF THE FRICTION OF SNOW SKIS SO JOURNAL OF SPORTS SCIENCES LA English DT Proceedings Paper CT Winter Sports Congress, on the Occasion of the 1992 Winter Olympic Games CY 1992 CL GRENOBLE, FRANCE DE FRICTION; SKIS; SNOW RP COLBECK, SC (reprint author), USA,CRREL,72 LYME RD,HANOVER,NH 03755, USA. NR 0 TC 38 Z9 38 U1 1 U2 18 PU E & FN SPON PI LONDON PA 2-6 BOUNDARY ROW, LONDON, ENGLAND SE1 8HN SN 0264-0414 J9 J SPORT SCI JI J. Sports Sci. PD JUN PY 1994 VL 12 IS 3 BP 285 EP 295 DI 10.1080/02640419408732174 PG 11 WC Sport Sciences SC Sport Sciences GA NP421 UT WOS:A1994NP42100008 PM 8064975 ER PT J AU LI, QG AF LI, QG TI AROMATIZATION AND HYDROLYSIS OF NORETHISTERONE-3-OXIME IN RABBIT SO JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY LA English DT Article ID PHARMACOKINETICS; NORETHINDRONE; PROGESTOGENS; STEROIDS AB Two pharmacologically active metabolites, norethisterone (NET) and ethinylestradiol (EE(2)), were detected by HPLC and HPLC-RIA methods in rabbit plasma following single i.v. and i.g. administration at a dose of 1 mg/20 mu Ci/kg of [H-3]norethisterone-3-oxime (NETO). Approximately 48% (i.v. injection) and 91% (i.g. administration) of the NETO dose were hydrolyzed to NET. Although only 0.35% of the NETO dose was aromatized to EE(2), due to its high estrogenic potency, EE, might contribute to the overall pharmacological pattern of NETO in the rabbit. RP LI, QG (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT PHARMACOL,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307, USA. NR 42 TC 3 Z9 3 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0960-0760 J9 J STEROID BIOCHEM JI J. Steroid Biochem. Mol. Biol. PD JUN PY 1994 VL 49 IS 2-3 BP 227 EP 231 PG 5 WC Biochemistry & Molecular Biology; Endocrinology & Metabolism SC Biochemistry & Molecular Biology; Endocrinology & Metabolism GA NU627 UT WOS:A1994NU62700014 PM 8031720 ER PT J AU BRUNS, AD FISHKIN, PA JOHNSON, EA LEE, YTM AF BRUNS, AD FISHKIN, PA JOHNSON, EA LEE, YTM TI MUNCHAUSEN-SYNDROME AND CANCER SO JOURNAL OF SURGICAL ONCOLOGY LA English DT Article DE MUNCHAUSEN SYNDROME; CANCER; SELF-INFLICTED INJURY AB Munchausen's syndrome is a chronic factitious disorder characterized by frequent hospitalizations, self-inflicted injuries, and dramatic medical histories. People with this condition assume the role of a sick patient and submit to unnecessary invasive, painful, and even dangerous medical procedures. In review of the literature, there have been four reports of patients feigning oncological disease. We admitted a 27-year-old woman who had undergone operative insertion of a Port-A-Cath and multiagent chemotherapy for ''advanced ovarian cancer.'' Physicians should be aware of Munchausen's syndrome in order to avoid costly medical procedures and unnecessary operations and to stop the patient's vicious circle of pathological lying and self-inflicted injury. (C) 1994 Wiley-Liss, Inc.* C1 TRIPLER ARMY MED CTR,DEPT SURG,SERV GEN SURG,HONOLULU,HI 96859. TRIPLER ARMY MED CTR,DIV HEMATOL ONCOL,HONOLULU,HI 96859. NR 12 TC 11 Z9 11 U1 0 U2 1 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0022-4790 J9 J SURG ONCOL JI J. Surg. Oncol. PD JUN PY 1994 VL 56 IS 2 BP 136 EP 138 DI 10.1002/jso.2930560219 PG 3 WC Oncology; Surgery SC Oncology; Surgery GA NU965 UT WOS:A1994NU96500018 PM 8007680 ER PT J AU LI, YL WHITE, MJ AF LI, YL WHITE, MJ TI A NOTE ON USING THE FAST FIELD PROGRAM SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Article ID SOUND-PROPAGATION; ATMOSPHERE; TUTORIAL; FFP AB The fast field program is a numerically efficient algorithm for computation of the sound pressure due to a time harmonic point source above a general boundary in a layered medium. In this method, the inverse Hankel transform for obtaining the pressure is approximated by two Fourier integrals. One of the Fourier integrals was treated as the incoming wave term and neglected in the computation of sound pressure. Actually, no one has theoretically proven that one of the Fourier integrals can be neglected. In this paper, it is shown that the neglected integral is necessary for the computation of low-frequency sound pressure when a pressure-release boundary is involved. C1 USA,CONSTRUCT ENGN RES LAB,CHAMPAIGN,IL 61826. RP LI, YL (reprint author), UNIV ILLINOIS,DEPT ELECT & COMP ENGN,WAVE PROPAGAT LAB,3RD FLOOR N CSRL,1308 W MAIN ST,URBANA,IL 61801, USA. RI White, Michael/B-3612-2009 OI White, Michael/0000-0001-8450-9135 NR 12 TC 6 Z9 6 U1 1 U2 1 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0001-4966 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD JUN PY 1994 VL 95 IS 6 BP 3100 EP 3102 DI 10.1121/1.409876 PG 3 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA NR920 UT WOS:A1994NR92000007 ER PT J AU SUMMERS, V LEEK, MR AF SUMMERS, V LEEK, MR TI THE INTERNAL REPRESENTATION OF SPECTRAL CONTRAST IN HEARING-IMPAIRED LISTENERS SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Article ID AUDITORY FILTER SHAPES; FREQUENCY-SELECTIVITY; VOWEL IDENTIFICATION; DISCRIMINATION; ASYMMETRY; NOISE AB Abnormal frequency resolution associated with sensorineural hearing impairment produces a smearing of spectral detail in the internal representation of complex acoustic stimuli. As a result, listeners with hearing loss may have difficulty locating spectral peaks (e.g., vowel formants) within stimuli which cue their identity. This study examined the relationship between frequency separation of peaks in a complex spectrum and the degree of spectral contrast preserved in the internal representations in normal and impaired auditory systems. Hearing-impaired and normal-hearing subjects discriminated a flat-spectrum bandpass stimulus from a stimulus containing a sinusoidal ripple across its frequency range. The peak-to-valley amplitude (in dB) necessary for detection of the ripple was measured for ripple frequencies ranging from 1 to 9 cycles/oct. Auditory filter characteristics were also measured at 1 and 3 kHz in order to examine the internal representations of the stimuli after cochlear processing. There were clear differences between groups in both auditory filter characteristics and spectral contrast detection. However, the amount of contrast in the internal representations predicted from these measurements was nearly the same for all subjects, suggesting that the reduced frequency resolution of the hearing-impaired group was largely responsible for differences in required peak-to-valley amplitude in the input spectra. Further, for all subjects, there was a trade-off between the absolute level of internal contrast necessary for ripple detection and the number of samples of this contrast available to the listener. RP SUMMERS, V (reprint author), WALTER REED ARMY MED CTR,CTR ARMY AUDIOL & SPEECH,WASHINGTON,DC 20307, USA. FU NIDCD NIH HHS [DC 00626] NR 21 TC 48 Z9 49 U1 0 U2 1 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0001-4966 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD JUN PY 1994 VL 95 IS 6 BP 3518 EP 3528 DI 10.1121/1.409969 PG 11 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA NR920 UT WOS:A1994NR92000048 PM 8046143 ER PT J AU GIANDONI, MB GRABSKI, WJ AF GIANDONI, MB GRABSKI, WJ TI CUTANEOUS CANDIDIASIS AS A CAUSE OF DELAYED SURGICAL-WOUND HEALING SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Article AB Background: Reports in the literature of surgical wounds infected with Candida species are scant. Objective: We describe a subset of patients with cutaneous candidiasis whose only clinical finding was delayed wound healing. Methods: Surgical wounds managed with moist occlusive postoperative dressings were observed for delayed healing. Results: Three patients are described who demonstrated delayed wound healing with failure to epithelialize. Fungal cultures from each patient revealed heavy growth of Candida. The problem resolved quickly with a modified wound care regimen and application of an antiyeast cream. Conclusion: Cutaneous candidiasis can be a cause of delayed wound healing, especially in surgical wounds treated with antibacterial ointments and occlusive dressings. RP GIANDONI, MB (reprint author), BROOKE ARMY MED CTR,DERMATOL SERV,SAN ANTONIO,TX, USA. NR 7 TC 12 Z9 12 U1 0 U2 1 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD JUN PY 1994 VL 30 IS 6 BP 981 EP 984 PG 4 WC Dermatology SC Dermatology GA NP003 UT WOS:A1994NP00300011 PM 8188892 ER PT J AU GIANDONI, MB GRABSKI, WJ AF GIANDONI, MB GRABSKI, WJ TI SURGICAL PEARL - THE DERMAL BURIED PULLEY SUTURE SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Note RP GIANDONI, MB (reprint author), BROOKE ARMY MED CTR,FT SAM HOUSTON,TX, USA. NR 6 TC 11 Z9 11 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD JUN PY 1994 VL 30 IS 6 BP 1012 EP 1013 PG 2 WC Dermatology SC Dermatology GA NP003 UT WOS:A1994NP00300017 PM 8188863 ER PT J AU PLICHTA, EJ BEHL, WK CHANG, WHS SCHLEICH, DM AF PLICHTA, EJ BEHL, WK CHANG, WHS SCHLEICH, DM TI THE RECHARGEABLE LIAL/LI3.6GE0.6V0.4O4/TIS2 HIGH-TEMPERATURE SOLID-STATE CELL SO JOURNAL OF THE ELECTROCHEMICAL SOCIETY LA English DT Article ID IONIC-CONDUCTIVITY AB An all solid-state high temperature cell is described using a solid solution of lithium germanium oxide (Li4GeO4) and lithium vanadium oxide (Li3VO4) with a general formula, Li3.6Ge0.6V0.4O4, as the lithium ion conducting solid electrolyte. The cyclic voltammetric experiments with the solid electrolyte exhibited the reversible deposition of lithium metal at platinum and gold working electrodes at potentials below ca. 0.5 V vs. the lithium-aluminum reference and showed the solid electrolyte to be electrochemically stable toward any oxidation up to a potential of ca. 4.5 V vs. a lithium-aluminum reference electrode. The cells employed a lithium-aluminum alloy as the anode and a chemical vapor deposited thin film of titanium disulfide as the cathode, and exhibited an open-circuit potential of ca. 2.1 V at 300-degrees-C. The cells exhibited excellent high rate capabilities and were discharged at current densities up to 100 mA/cm2. C1 POLYTECH INST NEW YORK,BROOKLYN,NY 11201. RP PLICHTA, EJ (reprint author), USA,ELECTR & POWER SOURCES DIRECTORATE,RES LAB,FT MONMOUTH,NJ 07703, USA. NR 10 TC 2 Z9 2 U1 3 U2 6 PU ELECTROCHEMICAL SOC INC PI PENNINGTON PA 10 SOUTH MAIN STREET, PENNINGTON, NJ 08534 SN 0013-4651 J9 J ELECTROCHEM SOC JI J. Electrochem. Soc. PD JUN PY 1994 VL 141 IS 6 BP 1418 EP 1421 DI 10.1149/1.2054940 PG 4 WC Electrochemistry; Materials Science, Coatings & Films SC Electrochemistry; Materials Science GA NQ338 UT WOS:A1994NQ33800008 ER PT J AU SANTEE, WR MATTHEW, WT BLANCHARD, LA AF SANTEE, WR MATTHEW, WT BLANCHARD, LA TI EFFECTS OF METEOROLOGICAL PARAMETERS ON ADEQUATE EVALUATION OF THE THERMAL ENVIRONMENT SO JOURNAL OF THERMAL BIOLOGY LA English DT Article DE CLOTHING; METEOROLOGY; HEAT TRANSFER; HUMAN PHYSIOLOGY; WBGT; HEAT STRAIN ID HEAT; ANIMALS; STRAIN AB 1. Field measurements of the thermal environment were made during an outdoor study of eight subjects conducted at Fort Bliss, TX, U.S.A. 2. Meteorological parameters measured were temperatures, solar radiation, wind speed and humidity. 3. On two consecutive days, the rise in rectal temperatures for subjects wearing comparable chemical protective garments and carrying 22 kg loads averaged 0.5-degrees-C h-1 vs 0.2-degrees-C h-1. 4. The difference may be attributable to differences of 2.7-degrees-C in dewpoint temperature and 1.2 m s-1 in wind speed, indicating that a small difference in meterological parameters can have an impact on individuals' thermal responses. RP SANTEE, WR (reprint author), USA,ENVIRONM MED RES INST,NATICK,MA 01760, USA. NR 25 TC 3 Z9 3 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0306-4565 J9 J THERM BIOL JI J. Therm. Biol. PD JUN PY 1994 VL 19 IS 3 BP 187 EP 198 DI 10.1016/0306-4565(94)90030-2 PG 12 WC Biology; Zoology SC Life Sciences & Biomedicine - Other Topics; Zoology GA NT641 UT WOS:A1994NT64100005 ER PT J AU SEIKEN, G GRILLO, FG SCHAUDIES, RP JOHNSON, JP AF SEIKEN, G GRILLO, FG SCHAUDIES, RP JOHNSON, JP TI MODULATION OF RENAL EGF IN DICHROMATE-INDUCED ACUTE-RENAL-FAILURE TREATED WITH THYROID-HORMONE SO KIDNEY INTERNATIONAL LA English DT Article ID EPIDERMAL GROWTH-FACTOR; MERCURIC-CHLORIDE; GENE-EXPRESSION; THYROXINE; TUBULE; RAT; NEPHROTOXICITY; RECOVERY; RECEPTOR; ISCHEMIA AB Administration of either thyroid hormone or epidermal growth factor (EGF) ameliorates injury in a variety of experimental acute renal failure (ARF) models. Since thyroid hormone augments EGF release and EGF receptor expression, a hypothesis suggesting that the mechanism of thyroid action is via EGF appears attractive. The present study is an attempt to evaluate the role of EGF in thyroid mediated protection from ARF induced in rats by dichromate. Penal parenchymal levels of acid extractable endogenous EGF were measured by RIA in dichromate exposed, otherwise untreated animals and in those receiving dichromate followed by thyroid. In the untreated case serum creatinine peaked at 2.5 mg % on the third day following dichromate exposure. Endogenous levels of EGF closely paralleled serum creatinine with a six-fold increase observed at peak injury. The source of EGF increase appeared to be a membrane bound precursor as soluble levels of EGF rose in injured kidneys at the expense of Triton-X-100 extractable, immunoreactive material that upon treatment with trypsin yielded additional EGF. T-3 administered one hour following dichromate resulted in significant functional protection (peak injury serum creatinines 2.63 +/- 0.76 control vs. 0.98 +/- 0.14 with T-3) as well as an approximate doubling in renal EGF levels at 24, 48 and 72 hours (4.7 +/- 0.3 vs. 9.7 +/- 0.8 at 24 hr, 33.5 +/- 6.5 vs. 63.2 +/- 20.0 at 48 hr, and 23.1 +/- 10.0 vs. 44.1 +/- 8.7 ng/g wet weight at 72 hr). There was no beneficial effect of exogenous EGF on renal function either when given in conjunction with T-3 or when used alone. These data suggest the existence of a self protection mechanism where injured renal tissues release EGF to stimulate repair and recovery. C1 WALTER REED ARMY INST RES,DEPT NEPHROL,WASHINGTON,DC 20307. NR 23 TC 12 Z9 12 U1 0 U2 0 PU BLACKWELL SCIENCE INC PI CAMBRIDGE PA 238 MAIN ST, CAMBRIDGE, MA 02142 SN 0085-2538 J9 KIDNEY INT JI Kidney Int. PD JUN PY 1994 VL 45 IS 6 BP 1622 EP 1627 DI 10.1038/ki.1994.213 PG 6 WC Urology & Nephrology SC Urology & Nephrology GA NM688 UT WOS:A1994NM68800010 PM 7933809 ER PT J AU WARD, JA HILLIARD, JK AF WARD, JA HILLIARD, JK TI B-VIRUS-SPECIFIC PATHOGEN-FREE (SPF) BREEDING COLONIES OF MACAQUES - ISSUES, SURVEILLANCE, AND RESULTS IN 1992 SO LABORATORY ANIMAL SCIENCE LA English DT Article AB The NIH's National Center for Research Resources, Comparative Medicine Program has sponsored. a multi-institutional program for the establishment of specific pathogen-free (SPF) macaque colonies. Herpes B virus (Cercopithecine herpesvirus I) has been targeted as part of this surveillance. Participating institutions have established individual timetables for frequency of testing, types of monitoring, and husbandry techniques, all with the common goal of producing pathogen-free monkeys for research. From January 1990 through December 1992 we screened animals for evidence of B virus infection, using ELISA and immunoblot to detect humoral antibodies. A total of 984 animals were tested during the first year of the program. At the start of the third year, 631 animals remained in our testing program. Of the 36.9% eliminated for all causes over a 3-year period, B virus screening accounted for 12.1, 1.2, and 0.5% during years 1, 2, and 3, respectively The greatest threat to the success of the program comes from failure to detect seronegative animals with latent infections, if they do indeed exist, either in first-year animals or animals introduced in subsequent years. The best assurance that a colony is SPF comes from negative results of repeated testing. Introducing new animals into an established SPF colony should be done only after careful screening. Simulations using mathematical models suggest that the best way to detect seronegative animals with latent infections is monthly or bimonthly testing separated by a waiting period. Duration of the waiting period cannot be defined precisely until more is known about the reactivation potential of putative seronegative animals with latent infections. C1 SW FDN BIOMED RES,DEPT VIROL & IMMUNOL,SAN ANTONIO,TX. RP WARD, JA (reprint author), BROOKE ARMY MED CTR,DEPT CLIN INVEST,SAN ANTONIO,TX, USA. FU NCRR NIH HHS [RR05062] NR 3 TC 35 Z9 35 U1 0 U2 1 PU AMER ASSOC LABORATORY ANIMAL SCIENCE PI CORDOVA PA 70 TIMBERCREEK DR, SUITE 5, CORDOVA, TN 38018 SN 0023-6764 J9 LAB ANIM SCI JI Lab. Anim. Sci. PD JUN PY 1994 VL 44 IS 3 BP 222 EP 228 PG 7 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA NU954 UT WOS:A1994NU95400004 PM 7933967 ER PT J AU EISENHAUER, CL MATSUDA, LS UYEHARA, CFT AF EISENHAUER, CL MATSUDA, LS UYEHARA, CFT TI NORMAL PHYSIOLOGICAL VALUES OF NEONATAL PIGS AND THE EFFECTS OF ISOFLURANE AND PENTOBARBITAL-ANESTHESIA SO LABORATORY ANIMAL SCIENCE LA English DT Article ID POSTNATAL-DEVELOPMENT; BIOMEDICAL-RESEARCH; NEWBORN PIGLET; PLASMA; CATECHOLAMINES; CIRCULATION; RESPONSES; HALOTHANE; FETAL; SWINE AB The newborn piglet is becoming increasingly popular as a model for neonatal studies. However data on normal physiologic baseline values and the influence of anesthesia on these values are scarce. In this study, we describe husbandry, surgical, and experimental methods used to establish a conscious, chronically catheterized neonatal piglet model, which enabled study of unrestrained piglets recovered from surgery and anesthesia, for up to 10 days after separation from the sow Chronic catheterization allowed repeated experiments to be performed in the same animals, reducing the number of animals needed for study Presented herein are baseline resting hemodynamic and blood chemistry data and circulating hormone measurements of vasopressin, plasma renin activity, adrenocorticotrophic hormone, cortisol, epinephrine, norepinephrine, and dopamine for piglets in the first 2 weeks of life. Also, in two series of experiments, the effects of the gas anesthetic isoflurane and the injectable anesthetic pentobarbital on these baseline values were investigated. Results indicate that both pentobarbital and isoflurane elicit changes in blood pressure, heart rate, vasopressin, plasma renin activity and ventilatory drive that should be considered when using either of these anesthetic agents in acute studies. C1 TRIPLER ARMY MED CTR,DEPT CLIN INVEST,HONOLULU,HI 96859. KAPIOLANI MED CTR WOMEN & CHILDREN,DEPT NEONATOL,HONOLULU,HI 96826. NR 41 TC 21 Z9 21 U1 1 U2 2 PU AMER ASSOC LABORATORY ANIMAL SCIENCE PI CORDOVA PA 70 TIMBERCREEK DR, SUITE 5, CORDOVA, TN 38018 SN 0023-6764 J9 LAB ANIM SCI JI Lab. Anim. Sci. PD JUN PY 1994 VL 44 IS 3 BP 245 EP 252 PG 8 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA NU954 UT WOS:A1994NU95400008 PM 7933971 ER PT J AU BURGESS, EB AF BURGESS, EB TI BRULES - COMBS,H SO LIBRARY JOURNAL LA English DT Book Review RP BURGESS, EB (reprint author), TRALINET CTR,USA,FT MONROE,VA, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 SN 0363-0277 J9 LIBR J JI Libr. J. PD JUN 1 PY 1994 VL 119 IS 10 BP 154 EP & PG 0 WC Information Science & Library Science SC Information Science & Library Science GA NN211 UT WOS:A1994NN21100187 ER PT J AU ESTEP, L LILLYCROP, J PARSON, L AF ESTEP, L LILLYCROP, J PARSON, L TI ESTIMATION OF MAXIMUM DEPTH OF PENETRATION OF A BATHYMETRIC LIDAR SYSTEM USING A SECCHI DEPTH DATABASE SO MARINE TECHNOLOGY SOCIETY JOURNAL LA English DT Article ID OPTICAL-PROPERTIES; WATERS AB Equations relating Secchi Depth (SD) and Maximum Depth of Penetration (MDP) of a lidar bathymetry system are developed. The equations are based on a system signal-to-noise equation, propagation contrast model, a relationship between the irradiance attenuation coefficient, k, and the beam attenuation coefficient, c; and a relationship between the lidar bathymetry system attenuation coefficient and c. The resulting equations allow a seasonal Secchi depth database to serve as a project planning tool and deployment aid for an airborne lidar bathymeter system for both day and night time operations. RP ESTEP, L (reprint author), USA,CORPS ENGN,COASTAL ENGN RES CTR,WATERWAYS EXPT STN,VICKSBURG,MS 39180, USA. NR 19 TC 4 Z9 4 U1 0 U2 2 PU MARINE TECHNOLOGY SOC INC PI WASHINGTON PA C/O I CLAYION MATTHEWS, 1828 L ST, NW, 9TH FL, WASHINGTON, DC 20036 SN 0025-3324 J9 MAR TECHNOL SOC J JI Mar. Technol. Soc. J. PD SUM PY 1994 VL 28 IS 2 BP 30 EP 36 PG 7 WC Engineering, Ocean; Oceanography SC Engineering; Oceanography GA PQ197 UT WOS:A1994PQ19700005 ER PT J AU RYAN, MS AF RYAN, MS TI THE BETRAYED PROFESSION - LAWYERING AT THE END OF THE 20TH-CENTURY (SCRIBNERS 1994) - LINOWITZ,SM, MAYER,M SO MILITARY LAW REVIEW LA English DT Book Review C1 USA,JUDGE ADVOCATE GEN CORPS,WASHINGTON,DC 20310. US MIL ACAD,DEPT LAW,W POINT,NY 10996. NR 5 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD SUM PY 1994 VL 145 BP 179 EP 182 PG 4 WC Law SC Government & Law GA QX644 UT WOS:A1994QX64400005 ER PT J AU SAVIANO, TJ AF SAVIANO, TJ TI OPERATION CROSSROADS - THE ATOMIC TESTS AT BIKINI ATOLL - WEISGALL,JM SO MILITARY LAW REVIEW LA English DT Book Review C1 USA,JUDGE ADVOCATE GEN SCH,WASHINGTON,DC 20310. NR 1 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD SUM PY 1994 VL 145 BP 193 EP 197 PG 5 WC Law SC Government & Law GA QX644 UT WOS:A1994QX64400008 ER PT J AU HOWLETT, DB AF HOWLETT, DB TI A FROLIC OF HIS OWN - GADDIS,W SO MILITARY LAW REVIEW LA English DT Book Review C1 USA,JUDGE ADVOCATE GEN CORPS,WASHINGTON,DC 20310. NR 1 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD SUM PY 1994 VL 145 BP 208 EP 210 PG 3 WC Law SC Government & Law GA QX644 UT WOS:A1994QX64400011 ER PT J AU WITTICH, AC DESANTIS, RA AF WITTICH, AC DESANTIS, RA TI LAPAROSCOPICALLY ASSISTED VAGINAL HYSTERECTOMY IN AN ARMY MEDICAL-CENTER SO MILITARY MEDICINE LA English DT Article AB Over the past 5 years, laparoscopic assisted vaginal hysterectomy (LAVH) has progressed from an experimental procedure to an alternative operation when abdominal hysterectomy is indicated. During a 15-month period, 31 patients underwent LAVH at Tripler Army Medical Center for treatment of gynecologic conditions that traditionally required abdominal hysterectomy. The benefits of the procedure and the complications encountered during surgery are discussed. A comparison of our data with data presented in other reports in the literature is considered favorable. While the complication rate was 16%, there was no mortality or serious morbidity. With experience and proper training of gynecologic surgeons, LAVH is an alternative to abdominal hysterectomy in selected cases. RP WITTICH, AC (reprint author), TRIPLER ARMY MED CTR,DEPT OBSTET & GYNECOL,TRIPLER AMC,HI 96859, USA. NR 0 TC 2 Z9 2 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUN PY 1994 VL 159 IS 6 BP 429 EP 432 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA PG420 UT WOS:A1994PG42000003 PM 7984298 ER PT J AU MCALISTER, WH WINGERT, TA HANDLY, RM AF MCALISTER, WH WINGERT, TA HANDLY, RM TI UNITED-STATES-ARMY RESERVE OPTOMETRY MOBILIZATION IN SUPPORT OF OPERATIONS DESERT SHIELD AND DESERT-STORM SO MILITARY MEDICINE LA English DT Article AB Reserve participation contributed significantly to the successful optometric support of the U.S. Army in Operations Desert Shield and Desert Storm. This survey profiles the experiences of reserve optometry officers during these operations. Many doctors suffered personal and financial hardship, the latter being particularly common for those in private practice settings. Readiness may be impaired as many responses indicated that a considerable number plan to separate from the reserve in order to avoid future activation. RP MCALISTER, WH (reprint author), USA,ENVIRONM HYG AGCY,ABERDEEN PROVING GROUND,MD 21010, USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUN PY 1994 VL 159 IS 6 BP 442 EP 444 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA PG420 UT WOS:A1994PG42000007 PM 7984302 ER PT J AU WATANABE, HK NEWBY, J MARLOWE, D JENSEN, PS CORTES, RM AF WATANABE, HK NEWBY, J MARLOWE, D JENSEN, PS CORTES, RM TI THE EXCEPTIONAL FAMILY MEMBER PROGRAM - VIEWS OF UNIT LEADERS SO MILITARY MEDICINE LA English DT Article AB This survey indicated that unit leaders perceived the Army Exceptional Family Member Program (EFMP) positively and considered the program beneficial to the Army, the soldiers, and their families. Furthermore, the unit leaders considered the EFMP soldiers to be well accepted in their units and their duty performance to be comparable to that of non-EFMP soldiers. RP WATANABE, HK (reprint author), WALTER REED ARMY INST RES,DEPT MIL PSYCHIAT,DIV NEUROPSYCHIAT,WASHINGTON,DC 20005, USA. OI Jensen, Peter/0000-0003-2387-0650 NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUN PY 1994 VL 159 IS 6 BP 449 EP 453 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA PG420 UT WOS:A1994PG42000009 PM 7984304 ER PT J AU KOSHES, RJ ROTHBERG, JM AF KOSHES, RJ ROTHBERG, JM TI USE OF INPATIENT PSYCHIATRIC-SERVICES ON A UNITED-STATES-ARMY COMBAT SUPPORT POST DURING OPERATIONS DESERT-SHIELD AND DESERT-STORM - THE STRESS OF NON-DEPLOYMENT SO MILITARY MEDICINE LA English DT Article AB We studied the utilization of inpatient psychiatric services during Operations Desert Shield and Desert Storm (the Persian Gulf War of 1990-1991) on a U.S. Army combat support post. Inpatient psychiatric admissions and dispositions for the post's catchment area were tallied before, during, and after Operations Desert Shield and Desert Storm. Subjects included active duty soldiers (deployed soldiers were not studied while they were away from the post), their families, and retirees. Overall, there was no increase in psychiatric hospitalizations for active duty soldiers, their family members, or retirees. However, coincident with the return of soldiers from Operations Desert Shield and Desert Storm, the psychiatric proportion of all hospitalizations increased in the subpopulation of soldiers not deployed who had served less than 1 year. These soldiers in training may be more susceptible to increased stress levels associated with the return of soldiers from war because of their inadequate group bonding. C1 WALTER REED ARMY INST RES,DEPT MIL PSYCHIAT,WASHINGTON,DC 20307. NR 0 TC 1 Z9 1 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUN PY 1994 VL 159 IS 6 BP 454 EP 456 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA PG420 UT WOS:A1994PG42000010 PM 7984305 ER PT J AU LI, J WIRTZ, RA MCCONKEY, GA SATTABONGKOT, J MCCUTCHAN, TF AF LI, J WIRTZ, RA MCCONKEY, GA SATTABONGKOT, J MCCUTCHAN, TF TI TRANSITION OF PLASMODIUM-VIVAX RIBOSOME TYPES CORRESPONDS TO SPOROZOITE DIFFERENTIATION IN THE MOSQUITO SO MOLECULAR AND BIOCHEMICAL PARASITOLOGY LA English DT Article DE PLASMODIUM VIVAX; SSURRNA; 18S RIBOSOMAL-RNA; DEVELOPMENTAL DIAGNOSTICS ID RNA GENES; FALCIPARUM; SEQUENCE; EVOLUTION; BERGHEI; NUMBER AB Two distinct small subunit ribosomal RNA (SSUrRNA) genes were amplified from the genomic DNA of Plasmodium vivax. Comparison of the two coding sequences reveals an overall divergence of 14.5% and most differences are clustered into the regions known to diverge rapidly in all eukaryotic SSUrRNAs. Oligonucleotides complementary to unique sequences of each gene have been used to distinguish the transcripts expressed either at schizogony in human blood (A gene) or at sporogony in the mosquito (C gene). These oligonucleotides were also used to monitor turnover of ribosomes during parasite development in mosquitoes. Transcripts of the A gene were predominant in the infected human blood and engorged mosquitoes but disappeared within 24 h after feeding. Expression of the C gene in mosquitoes was not detected until day 6 after the blood meal. A period of rapid accumulation of the C type rRNA from day 6 to day 8 corresponds to differentiation of individual sporozoites within the oocyst. Possible functional implications relating to the timing of this transition are discussed. C1 NIAID,MALARIA RES LAB,MOLEC BIOL SECT,BETHESDA,MD 20892. UNIFORMED SERV UNIV HLTH SCI,DEPT PREVENT MED & BIOMETR,BETHESDA,MD 20814. WALTER REED ARMY INST RES,DEPT ENTOMOL,DIV COMMUN DIS & IMMUNOL,WASHINGTON,DC 20307. USA,MED COMPONENT,DEPT ENTOMOL,BANGKOK,THAILAND. NR 21 TC 32 Z9 38 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-6851 J9 MOL BIOCHEM PARASIT JI Mol. Biochem. Parasitol. PD JUN PY 1994 VL 65 IS 2 BP 283 EP 289 DI 10.1016/0166-6851(94)90079-5 PG 7 WC Biochemistry & Molecular Biology; Parasitology SC Biochemistry & Molecular Biology; Parasitology GA NX674 UT WOS:A1994NX67400009 PM 7969269 ER PT J AU LU, Y ALARCON, CM HALL, T REDDY, LV DONELSON, JE AF LU, Y ALARCON, CM HALL, T REDDY, LV DONELSON, JE TI A STRAND BIAS OCCURS IN POINT MUTATIONS ASSOCIATED WITH VARIANT SURFACE GLYCOPROTEIN GENE CONVERSION IN TRYPANOSOMA RHODESIENSE SO MOLECULAR AND CELLULAR BIOLOGY LA English DT Article ID ANTIGENIC VARIATION; BRUCEI-RHODESIENSE; AFRICAN TRYPANOSOMES; TELOMERIC DNA; CELL-LINE; TRANSCRIPTION; RECOMBINATION; MECHANISM; REPAIR; PSEUDOGENES AB We previously described a bloodstream Trypansoma rhodesiense clone, MVAT5-Rx2, whose isolation was based on its cross-reactivity with a monoclonal antibody (MAb) directed against a metacyclic variant surface glycoprotein (VSG). When the duplicated, expressed VSG gene in MVAT5-Rx2 was compared with its donor (basic copy) gene, 11 nucleotide differences were found in the respective 1.5-kb coding regions (Y. Lu, T. Hall, L. S. Gay, and J. E. Donelson, Cell 72:397-406, 1993). Here we describe a characterization of two additional bloodstream trypanosome clones, MVAT5-Rx1 and MVAT5-Rx3, whose VSGs are expressed from duplicated copies of the same donor VSG gene. The three trypanosome clones each react with the MVAT5-specific MAb, but they have different cross-reactivities with a panel of other MAbs, suggesting that their surface epitopes are similar but nonidentical. Each of the three gene duplication events occurs at a different 5' crossover site within a 76-bp repeat and is associated with a different set of point mutations. The 35, 11, and 28 point mutations in the duplicated VSG coding regions of Rx1, Rx2, and Rx3, respectively, exhibit a strand bias. In the sense strand, of the 74 total mutations generated in the three duplications, 54% are A-to-G or G-to-A (A:G) transitions and 7% are C:T transitions, while 26% are C:A transversions and 13% are C:G transversions. No T:G or T:A transversions occurred. Possible models for the generation of these point mutations are discussed. C1 UNIV IOWA,DEPT BIOCHEM,IOWA CITY,IA 52242. UNIV IOWA,GENET PHD PROGRAM,IOWA CITY,IA 52242. UNIV IOWA,HUMAN NUTR PROGRAM,IOWA CITY,IA 52242. UNIV IOWA,HOWARD HUGHES MED INST,IOWA CITY,IA 52242. WALTER REED ARMY INST RES,DEPT IMMUNOL,WASHINGTON,DC 20307. RI Donelson, John/F-5795-2010 NR 41 TC 26 Z9 26 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0270-7306 J9 MOL CELL BIOL JI Mol. Cell. Biol. PD JUN PY 1994 VL 14 IS 6 BP 3971 EP 3980 PG 10 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA NM741 UT WOS:A1994NM74100043 PM 8196636 ER PT J AU SCALORA, M CRENSHAW, ME AF SCALORA, M CRENSHAW, ME TI A BEAM-PROPAGATION METHOD THAT HANDLES REFLECTIONS SO OPTICS COMMUNICATIONS LA English DT Article ID DESIGN; MEDIA AB We review the fast Fourier transform beam propagation method (FFT-BPM) that is commonly used to describe diffraction of electromagnetic waves and introduce a time-domain version that takes into account arbitrary longitudinal index profiles, as well as transverse effects. This method can describe all relevant aspects of paraxial propagation in linear or nonlinear media. That is, the technique can handle transmission, diffraction, and, in particular, reflection of electromagnetic waves. RP SCALORA, M (reprint author), USA,MISSILE COMMAND,AMSMI RD WS RES,CTR DEV & ENGN,WEAPONS SCI DIRECTORATE,REDSTONE ARSENAL,AL 35898, USA. NR 22 TC 69 Z9 71 U1 0 U2 4 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0030-4018 J9 OPT COMMUN JI Opt. Commun. PD JUN 1 PY 1994 VL 108 IS 4-6 BP 191 EP 196 DI 10.1016/0030-4018(94)90647-5 PG 6 WC Optics SC Optics GA NP150 UT WOS:A1994NP15000002 ER PT J AU BURROWS, EP AF BURROWS, EP TI DIMETHYL ETHER AND DIMETHYL-D6 ETHER CHEMICAL-IONIZATION MASS-SPECTROMETRY OF NITRAMINES, NITROAROMATICS AND RELATED-COMPOUNDS SO ORGANIC MASS SPECTROMETRY LA English DT Article ID ION-MOLECULE REACTIONS; SPECTRAL FRAGMENTATION PATHWAYS; INDUCED DISSOCIATION; HMX; RDX AB Dimethyl ether (DME) chemical ionization mass spectrometry with introduction by direct exposure desorption was utilized for the characterization of a variety of nitramines, nitroaromatics and related compounds. For the nitramines and for many of the nitroaromatics the most abundant ions were fragment-molecule adduct ions resulting from ion-molecule reactions with the reagent gas. Nitroaromatic positional isomers were readily distinguished by large differences in the abundances of the various adduct ions. For the nitramines, collision-induced dissociations of the prominent methoxymethylene adduct ions were studied and contrasted with those of the corresponding adducts derived from DME-d6 as reagent gas. RP BURROWS, EP (reprint author), USA,BIOMED RES & DEV LAB,FREDERICK,MD 21702, USA. NR 17 TC 14 Z9 14 U1 0 U2 1 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0030-493X J9 ORG MASS SPECTROM JI Org. Mass Spectrom. PD JUN PY 1994 VL 29 IS 6 BP 315 EP 320 DI 10.1002/oms.1210290609 PG 6 WC Chemistry, Organic; Spectroscopy SC Chemistry; Spectroscopy GA NT223 UT WOS:A1994NT22300008 ER PT J AU NEILL, A AF NEILL, A TI FILM AND PHENOMENOLOGY - TOWARD A REALIST THEORY OF CINEMATIC REPRESENTATION - CASEBIER,A SO PHILOSOPHY AND PHENOMENOLOGICAL RESEARCH LA English DT Book Review RP NEILL, A (reprint author), TRIPLER ARMY MED CTR,HONOLULU,HI 96859, USA. NR 1 TC 0 Z9 0 U1 0 U2 1 PU PHILOSOPHY PHENOMENOLOGICAL RES PI PROVIDENCE PA BROWN UNIV BOX 1947, PROVIDENCE, RI 02912 SN 0031-8205 J9 PHILOS PHENOMEN RES JI Philos. Phenomenol. Res. PD JUN PY 1994 VL 54 IS 2 BP 486 EP 488 DI 10.2307/2108512 PG 3 WC Philosophy SC Philosophy GA NQ052 UT WOS:A1994NQ05200025 ER PT J AU BILLINGSLEY, JP ADAMS, CL AF BILLINGSLEY, JP ADAMS, CL TI APPLICATION OF CRYSTAL-LATTICE DISINTEGRATION CRITERIA TO COMPUTE MINIMUM SHOCK-INDUCED REACTIVE CONDITIONS IN SOLID EXPLOSIVES AND INERT MATERIALS SO PROPELLANTS EXPLOSIVES PYROTECHNICS LA English DT Article AB A threshold particle velocity criteria derived by E.R. Fitzgerald((2)) for the beginning of crystal lattice breakup and disintegration has been applied to shocked explosives and an inert material. In shocked explosives, reactions leading to detonation occur above a certain ''threshold'' magnitude. The computed crystal lattice breakup shock pressures compare rather well with observed experimental ''threshold'' shock pressures for six high explosives. The six explosives are: Comp-BS, Comp-B, TNT, PBX-9404, Tetryl, and H-6. In addition, the crystal lattice breakup criteria provides an explanation for the observed lowering of the detonation ''threshold'' shock pressure as the explosives are made more porous or less dense. Finally, the shock pressures, at which output from thermocouples embedded in shocked materials (PBX-9404 and Plexiglass) increases dramatically, compare favorably with predictions based on crystal lattice disintegration criteria. Consequently, it is tentatively concluded that crystal lattice breakup, or self-sustained phonon fission as Fitzgerald calls it, is responsible for the initiation of detonation in shocked explosives and enhanced thermocouple output in shocked materials. It is also postulated that the lattice breakup phenomena is also responsible for phase changes, increased chemical reactivity, and anomalous electrical activity which are observed in certain inert materials under relatively low level shock loading. C1 UNIV ALABAMA,RES INST,HUNTSVILLE,AL 35816. RP BILLINGSLEY, JP (reprint author), USA,MISSILE COMMAND,CTR DEV & ENGN,REDSTONE ARSENAL,AL 35898, USA. NR 24 TC 0 Z9 0 U1 0 U2 0 PU VCH PUBLISHERS INC PI DEERFIELD BEACH PA 303 NW 12TH AVE, DEERFIELD BEACH, FL 33442-1788 SN 0721-3115 J9 PROPELL EXPLOS PYROT JI Propellants Explos. Pyrotech. PD JUN PY 1994 VL 19 IS 3 BP 118 EP 126 DI 10.1002/prep.19940190303 PG 9 WC Chemistry, Applied; Engineering, Chemical SC Chemistry; Engineering GA QD843 UT WOS:A1994QD84300002 ER PT J AU MORRIS, MJT LONGFIELD, RN AF MORRIS, MJT LONGFIELD, RN TI SARCOIDOSIS AND ELISA FOR BORRELIA-BURGDORFERI SO SOUTHERN MEDICAL JOURNAL LA English DT Article ID LYME-DISEASE; ANTIBODY; TESTS AB Lyme disease can be confirmed by detection of IgM and IgG antibodies against the causative pathogen Borrelia burgdorferi. Enzyme-linked immunosorbent assay (ELISA) can be confirmatory within weeks of symptom onset. Sarcoidosis has not previously been reported as one of the disease processes associated with a false-positive ELISA for Lyme disease. In our study, Lyme ELISA was obtained in 25 patients with various degrees of activity of sarcoidosis. ELISA was positive for Lyme disease in only one of these patients. Sarcoidosis may not be one of the diseases that commonly results in a false-positive Lyme ELISA. C1 BROOKE ARMY MED CTR, INFECT DIS SERV, FT SAM HOUSTON, TX 78234 USA. NR 10 TC 7 Z9 7 U1 0 U2 1 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0038-4348 EI 1541-8243 J9 SOUTH MED J JI South.Med.J. PD JUN PY 1994 VL 87 IS 6 BP 590 EP 591 DI 10.1097/00007611-199406000-00002 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA NR658 UT WOS:A1994NR65800002 ER PT J AU DUNCAN, WE CHANG, A SOLOMON, B WARTOFSKY, L AF DUNCAN, WE CHANG, A SOLOMON, B WARTOFSKY, L TI INFLUENCE OF CLINICAL CHARACTERISTICS AND PARAMETERS ASSOCIATED WITH THYROID-HORMONE THERAPY ON THE BONE-MINERAL DENSITY OF WOMEN TREATED WITH THYROID-HORMONE SO THYROID LA English DT Article ID TOTALLY THYROIDECTOMIZED PATIENTS; THYROXINE REPLACEMENT THERAPY; LONGITUDINAL DATA-ANALYSIS; POSTMENOPAUSAL WOMEN; PREMENOPAUSAL WOMEN; CALCITONIN DEFICIENCY; PHOTON-ABSORPTIOMETRY; HYPOTHYROID PATIENTS; SERUM OSTEOCALCIN; HYPERTHYROIDISM AB Reports of reduced bone mineral density (BMD) in patients receiving long-term replacement and suppression therapy with L-thyroxine have generated considerable interest and controversy. A substantial literature has evolved, with interpretation of conflicting results obscured by a variety of confounding factors. We examined the BMD measurements of 202 white women who were taking thyroid hormone to determine the contribution to BMD of a number of clinical characteristics and parameters associated with thyroid hormone therapy. Measurements of BMD (N=335 over 2.6 F 1.6 years) of the spine (L(2)-L(4)) were performed in 195 subjects. The BMD of three sites of the hip was measured (N=247 over 1.8 +/- 1.1 years) in 157 subjects. The BMD of the proximal radius was also measured (N=172 over 1.8 +/- 1.2 years) in 124 subjects. Increasing age and a history of previous thyrotoxicosis had a deletrious effect on spine BMD. Body mass index (BMI) was positively correlated with spine BMD. Dose of thyroid hormone, duration of therapy, type of underlying thyroid disease, history of thyroidectomy, or serum-free thyroxine index did not influence either the initial BMD or the change in spine BMD over time. In the hip, age correlated with a decrease, and BMI with an increase in BMD. A history of previous thyrotoxicosis was associated with a decrease in hip BMD at all three sites (0.05

25 mg/kg/d) after 6-14 d. Neuropathological examination of rat brain sections at 5 levels from the rostral cerebrum to the caudal medulla showed a dose-related pattern of injury characterized by hyalinized neuron cell bodies and loss of Nissl substance; changes congruent with those noted in dogs. No significant difference was noted in the extent, type, or distribution of lesions in the brains of rats treated with equivalent doses of AE or AM. We conclude that (i) a neurological syndrome with central nervous system neuropathological changes occurred in a dose-related, and anatomically specific manner in both dogs and rats given moderately high daily doses of AE or AM; (ii) prolonged QTc interval was a preterminal clinical finding in dogs and rats treated with high dose AE; (iii) the mechanism and aetiology of these lesions was not determined in this study but a long-lived toxic drug metabolite is suggested. C1 UNIV ILLINOIS,DEPT PHARMACOL,TOXICOL RES LAB,CHICAGO,IL. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DIV PATHOL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DIV NEUROPSYCHIAT,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DIV VET MED,WASHINGTON,DC 20307. UNIV ILLINOIS,DEPT PHARMACOL,TOXICOL RES LAB,CHICAGO,IL. RP BREWER, TG (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307, USA. NR 15 TC 140 Z9 145 U1 0 U2 3 PU ROYAL SOC TROPICAL MEDICINE PI LONDON PA MANSON HOUSE 26 PORTLAND PLACE, LONDON, ENGLAND W1N 4EY SN 0035-9203 J9 T ROY SOC TROP MED H JI Trans. Roy. Soc. Trop. Med. Hyg. PD JUN PY 1994 VL 88 SU 1 BP 33 EP 36 DI 10.1016/0035-9203(94)90469-3 PG 4 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA NZ651 UT WOS:A1994NZ65100012 ER PT J AU KIM, BJ QI, SY SHANLEY, RS AF KIM, BJ QI, SY SHANLEY, RS TI HAZARDOUS-WASTE TREATMENT TECHNOLOGIES SO WATER ENVIRONMENT RESEARCH LA English DT Review ID BED GAC REACTOR; SURFACTANT-ENHANCED SOLUBILIZATION; ACTIVATED CARBON REGENERATION; CREOSOTE-CONTAMINATED SOIL; VOLATILE ORGANIC-COMPOUNDS; SEQUENCING BATCH REACTORS; REVERSE-BURN GASIFICATION; ROTARY KILN INCINERATION; DIGESTED SEWAGE-SLUDGE; LOADED TOLUENE SORBENT RP KIM, BJ (reprint author), USA, CONSTRUCT ENGN RES LABS, POB 9005, CHAMPAIGN, IL 61826 USA. RI Qi, Shaoying/A-2837-2008 NR 256 TC 2 Z9 2 U1 1 U2 2 PU WATER ENVIRONMENT FEDERATION PI ALEXANDRIA PA 601 WYTHE ST, ALEXANDRIA, VA 22314-1994 USA SN 1061-4303 J9 WATER ENVIRON RES JI Water Environ. Res. PD JUN PY 1994 VL 66 IS 4 BP 440 EP 455 PG 16 WC Engineering, Environmental; Environmental Sciences; Limnology; Water Resources SC Engineering; Environmental Sciences & Ecology; Marine & Freshwater Biology; Water Resources GA NW438 UT WOS:A1994NW43800026 ER PT J AU MOSSMAN, DJ ROIG, LC AF MOSSMAN, DJ ROIG, LC TI MIXING AND TRANSPORT SO WATER ENVIRONMENT RESEARCH LA English DT Review ID LARGE-AMPLITUDE MEANDERS; ENTERING SHALLOW-WATER; SAN-FRANCISCO BAY; MATHEMATICAL-MODEL; BED TOPOGRAPHY; FLOW PATTERNS; SELECTIVE WITHDRAWAL; CIRCULATION MODEL; STRATIFIED FLUID; GRAVITY CURRENTS C1 USA,CORPS ENGINEERS,WATERWAYS EXPT STN,VICKSBURG,MS 39180. RP MOSSMAN, DJ (reprint author), UNIV MISSOURI,DEPT CIVIL ENGN,CEP,5100 ROCKHILL RD,KANSAS CITY,MO 64110, USA. NR 255 TC 1 Z9 1 U1 0 U2 2 PU WATER ENVIRONMENT FEDERATION PI ALEXANDRIA PA 601 WYTHE ST, ALEXANDRIA, VA 22314-1994 SN 1061-4303 J9 WATER ENVIRON RES JI Water Environ. Res. PD JUN PY 1994 VL 66 IS 4 BP 477 EP 489 PG 13 WC Engineering, Environmental; Environmental Sciences; Limnology; Water Resources SC Engineering; Environmental Sciences & Ecology; Marine & Freshwater Biology; Water Resources GA NW438 UT WOS:A1994NW43800029 ER PT J AU WRAY, JE LIU, KC CHEN, CH GARRETT, WR PAYNE, MG GOEDERT, R TEMPLETON, D AF WRAY, JE LIU, KC CHEN, CH GARRETT, WR PAYNE, MG GOEDERT, R TEMPLETON, D TI OPTICAL POWER LIMITING OF FULLERENES SO APPLIED PHYSICS LETTERS LA English DT Article ID ABSORPTION; C-60; C-70 AB Optical power limiting processes in C60 solutions have been measured in a double-pass geometry designed to produce high beam attenuation. Based on the concentration of C60 and measured attenuation of laser fluence, it was found that, at high intensities, more than 100 visible (532 nm) photons per C60 molecule can be absorbed during a single 7-nanosecond laser pulse. The requisite features of such efficacious attenuation mechanisms are briefly discussed and a model meeting the requirements is described. C1 USA,TANK AUTOMOT COMMAND,WARREN,MI 48397. RP WRAY, JE (reprint author), OAK RIDGE NATL LAB,OAK RIDGE,TN 37831, USA. NR 12 TC 38 Z9 39 U1 0 U2 2 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD MAY 23 PY 1994 VL 64 IS 21 BP 2785 EP 2787 DI 10.1063/1.111470 PG 3 WC Physics, Applied SC Physics GA NN011 UT WOS:A1994NN01100009 ER PT J AU CIMECIOGLU, AL BALL, DH KAPLAN, DL HUANG, SH AF CIMECIOGLU, AL BALL, DH KAPLAN, DL HUANG, SH TI PREPARATION OF AMYLOSE DERIVATIVES SELECTIVELY MODIFIED AT C-6 - 6-AMINO-6-DEOXYAMYLOSE SO MACROMOLECULES LA English DT Article ID PRIMARY HYDROXYL-GROUPS; CARBOHYDRATE-CHEMISTRY; LITHIUM-CHLORIDE; CYCLODEXTRINS; CELLULOSE; N,N-DIMETHYLFORMAMIDE; TRIPHENYLPHOSPHINE; HALOGEN; AZIDES AB The synthesis of various amylose derivatives selectively modified at C-6 leading to the preparation of 6-amino-6-deoxyamylose (4) was carried out under homogeneous conditions. Amylose was initially halogenated directly at the primary carbon either by using methanesulfonyl chloride in dimethylformamide/lithium chloride as solvent, giving 6-chloro-6-deoxyamylose (1) or with triphenylphosphine and N-bromosuccinimide in dimethylformamide/lithium bromide, giving 6-bromo-6-deoxyamylose (2). Several of these derivatives with different degrees of substitution were prepared. C-6 chlorinated amyloses were then converted to the corresponding 6-azido-6-deoxyamylose analogs (3) by chloride displacement with azide ion in dipolar aprotic media. Triphenylphosphine facilitated reduction of these intermediates in dimethyl sulfoxide gave 6-amino-6-deoxyamyloses with the same degrees of substitution as the C-6 chlorinated precursors. Products were characterized in terms of the site and the extent of modifications using C-13 NMR, FTIR, HPLC, and elemental analyses. C1 USA,NATICK RD&E CTR,DIV BIOTECHNOL,NATICK,MA 01760. UNIV CONNECTICUT,INST MAT SCI,BIODEGRADABLE POLYMER RES CONSORTIUM,STORRS,CT 06269. NR 27 TC 28 Z9 28 U1 1 U2 10 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0024-9297 J9 MACROMOLECULES JI Macromolecules PD MAY 23 PY 1994 VL 27 IS 11 BP 2917 EP 2922 DI 10.1021/ma00089a004 PG 6 WC Polymer Science SC Polymer Science GA NP311 UT WOS:A1994NP31100004 ER PT J AU KHALED, EEM HILL, SC BARBER, PW AF KHALED, EEM HILL, SC BARBER, PW TI LIGHT-SCATTERING BY A COATED SPHERE ILLUMINATED WITH A GAUSSIAN-BEAM SO APPLIED OPTICS LA English DT Article ID MORPHOLOGY-DEPENDENT RESONANCES; FOCUSED LASER-BEAM; DIELECTRIC SPHERES; OPTICAL RESONANCES; INTERNAL FIELDS; SPECTROSCOPY; MICROSPHERES; DROPLETS AB The intensity of light scattered by a coated sphere illuminated with an off-axis Gaussian beam is calculated. Results are shown for different beam positions with respect to the sphere. As the beam is shifted further away from the surface of the sphere, the higher-Q morphology-dependent resonances become increasingly important in the backscatter spectra, and the angular scattering intensity becomes smoother. The scattered intensity depends on the beam position, the refractive indices of the core and coat, the radius of the core, and the thickness of the coat. As the beam is moved further away from the sphere, the effect of the core on the scattering intensity decreases. When the incident Gaussian beam is focused outside of a particle with a relatively small core, the scattering spectra and angular scattering patterns become similar to those of a homogeneous sphere having the refractive index of the coat. These calculated results suggest that measurements of spectral scattering and angular scattering patterns for several Gaussian beam positions could be useful for the characterization of coated spheres. C1 USA, RES LAB, WHITE SANDS MISSILE RANGE, NM 88002 USA. NEW MEXICO STATE UNIV, DEPT ELECT & COMP ENGN, LAS CRUCES, NM 88003 USA. DESERT RES INST, CTR ATMOSPHER SCI, RENO, NV 89506 USA. RP KHALED, EEM (reprint author), UNIV ASSIUT, DEPT ELECT & COMP ENGN, ASSIUT, EGYPT. NR 35 TC 21 Z9 23 U1 0 U2 1 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 0003-6935 J9 APPL OPTICS JI Appl. Optics PD MAY 20 PY 1994 VL 33 IS 15 BP 3308 EP 3314 PG 7 WC Optics SC Optics GA NM308 UT WOS:A1994NM30800023 PM 20885703 ER PT J AU ELSAYED, NM AF ELSAYED, NM TI TOXICITY OF NITROGEN-DIOXIDE - AN INTRODUCTION SO TOXICOLOGY LA English DT Article; Proceedings Paper CT Symposium on Effects of Exposure to Nitrogen Dioxide CY OCT 28, 1992 CL WALTER REED ARMY INST RES, WASHINGTON, DC HO WALTER REED ARMY INST RES DE NITROGEN DIOXIDE; INHALED OXIDANTS; MILITARY EXPOSURE; CIVILIAN EXPOSURE; PHOTOCHEMICAL OXIDANTS ID LIPID-PEROXIDATION; RAT LUNGS; PROTECTIVE SYSTEMS; ALPHA-TOCOPHEROL; VITAMIN-E; EXPOSURE; OZONE; ACID; OXIDANT; INHALATION AB Many questions, needed to advance our understanding of the mechanism of injury from high-level NO2, remain unanswered to date. This is partly due to the limited interest in the toxicity of high-level exposures, and partly due to the public pressure and interest to study the effects of low- (environmental) levels. However, the effects of exposure to high-level NO2 are of great interest to the military since high levels of NO2 may be found in combat situations. It is also important to the civilian section in occupational settings where accidents may occur as in silo filler accidents. To fill this gap in knowledge, the Department of Respiratory Research, Division of Medicine at Waiter Reed Army Institute of Research took the initiative and convened a panel of experts in a symposium to discuss in depth the effects of exposure to high-level nitrogen dioxide. The symposium goals were to address the issues beginning from the chemistry of NO2 molecule, to the dosimetry of its uptake (isolated lung), to the biological effects of exposure in vivo in small animals (rats), large animals (sheep), and finally in the most relevant species, humans. C1 UNIV CALIF LOS ANGELES,SCH PUBL HLTH,DEPT ENVIRONM HLTH SCI,LOS ANGELES,CA 90024. RP ELSAYED, NM (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT RESP RES,DIV MED,WASHINGTON,DC 20307, USA. NR 38 TC 28 Z9 28 U1 0 U2 1 PU ELSEVIER SCI IRELAND LTD PI CLARE PA CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE, IRELAND SN 0300-483X J9 TOXICOLOGY JI Toxicology PD MAY 20 PY 1994 VL 89 IS 3 BP 161 EP 174 DI 10.1016/0300-483X(94)90096-5 PG 14 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA NU842 UT WOS:A1994NU84200001 PM 8023327 ER PT J AU MAYORGA, MA AF MAYORGA, MA TI OVERVIEW OF NITROGEN-DIOXIDE EFFECTS ON THE LUNG WITH EMPHASIS ON MILITARY RELEVANCE SO TOXICOLOGY LA English DT Article; Proceedings Paper CT Symposium on Effects of Exposure to Nitrogen Dioxide CY OCT 28, 1992 CL WALTER REED ARMY INST RES, WASHINGTON, DC HO WALTER REED ARMY INST RES DE NITROGEN DIOXIDE; OCCUPATIONAL; MILITARY; CLINICAL; PATHOPHYSIOLOGY; INHALATION; PULMONARY; TOXICITY; OVERVIEW ID ARTERY ENDOTHELIAL-CELLS; ISOLATED RAT LUNGS; RESPIRATORY ILLNESS; NO2 EXPOSURE; LIPID-PEROXIDATION; INDUCED EMPHYSEMA; ANGIOTENSIN-II; AIR-POLLUTION; PULMONARY; INHALATION AB Nitrogen dioxide exposure occurs in many civilian occupations as well as during military combat. Little interaction has occurred between the two communities in regards to the exchange of information about NO2 research. This presentation provides an overview of NO2 related epidemiology; available research models and issues of particular interest to both the civilian and military sectors; clinical presentations, prophylaxis and treatment; and pathophysiology and mechanisms of injury. Throughout the presentation civilian and military issues are contrasted when pertinent. The most significant difference between the civilian and military research requirements is the need for information on chronic (with and without intermittent peaks) for the former, and information on acute high-level NO2 research for the latter. Another military requirement is predicting not only injury but incapacitation. This requirement can be compared to the need of clinicians to measure impairment for patients seeking disability. Both communities are faced with the same challenges of selecting appropriate models, understanding dosimetry and its many variables, clarifying the fate of inhaled NO2, developing specific markers of injury, and elucidating the mechanisms of NO2 injury for the development of prophylactic and therapeutic agents. Further research is required in these areas and it is hoped that this symposium will be the first attempt to join civilian and military resources and expertise for future research cooperation and collaboration. RP MAYORGA, MA (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT RESP RES,DIV MED,WASHINGTON,DC 20307, USA. NR 77 TC 6 Z9 7 U1 0 U2 2 PU ELSEVIER SCI IRELAND LTD PI CLARE PA CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE, IRELAND SN 0300-483X J9 TOXICOLOGY JI Toxicology PD MAY 20 PY 1994 VL 89 IS 3 BP 175 EP 192 DI 10.1016/0300-483X(94)90097-3 PG 18 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA NU842 UT WOS:A1994NU84200002 PM 8023328 ER PT J AU JANUSZKIEWICZ, AJ MAYORGA, MA AF JANUSZKIEWICZ, AJ MAYORGA, MA TI NITROGEN DIOXIDE-INDUCED ACUTE LUNG INJURY IN SHEEP SO TOXICOLOGY LA English DT Article; Proceedings Paper CT Symposium on Effects of Exposure to Nitrogen Dioxide CY OCT 28, 1992 CL WALTER REED ARMY INST RES, WASHINGTON, DC HO WALTER REED ARMY INST RES DE SHEEP; NITROGEN DIOXIDE; LUNG MECHANICS; HEMODYNAMICS; BRONCHOALVEOLAR LAVAGE ID HYPOXIC PULMONARY VASOCONSTRICTION; BRONCHOALVEOLAR LAVAGE; INHALATION INJURY; BLOOD-FLOW; EXPOSURE; OXYGEN; OZONE AB Lung mechanics; hemodynamics and blood chemistries were assessed in sheep (Ovis aries) before, and up to 24 h following, a 15-20 min exposure to either air (control) or approximately 500 ppm nitrogen dioxide (NO2). Histopathologic examinations of lung tissues were performed 24 h after exposure. Nose-only and lung-only routes of exposure were compared for effects on NO2 pathogenesis. Bronchoalveolar lavage fluids from air- and NO2-exposed sheep were analyzed for biochemical and cellular signs of NO2 insult. The influence of breathing pattern on NO2 dose was also assessed. Five hundred ppm NO2 exposure of intubated sheep (lung-only exposure) was marked by a statistically significant, albeit small, blood methemoglobin increase. The exposure induced an immediate tidal volume decrease, and an increase in both breathing rate and inspired minute ventilation. Pulmonary function, indexed by lung resistance and dynamic lung compliance, progressively deteriorated after exposure. Maximal lung resistance and dynamic lung compliance changes occurred at 24 h post exposure, concomitant with arterial hypoxemia. Bronchoalveolar lavage fluid epithelial cell number and total protein were significantly increased while macrophage number was significantly decreased within the 24 h post-exposure period. Histopathologic examination of lung tissue 24 h after NO2 revealed patchy edema, mild hemorrhage and polymorphonuclear and mononuclear leukocyte infiltration. The NO2 toxicologic profile was significantly attenuated when sheep were exposed to the gas through a face mask (nose-only exposure). Respiratory pattern was not significantly altered, lung mechanics changes were minimal, hypoxemia did not occur, and pathologic evidence of exudation was not apparent in nose-only, NO2-exposed sheep. The qualitative responses of this large animal species to high-level NO2 supports the concept of size dependent species sensitivity to NO2. In addition, when inspired minute ventilation was used as a dose-determinant, a linear relationship between NO2 dose and lung resistance was found. The importance of these findings, NO2 dose-determinants, and the utility of sheep as a large animal inhalation model are discussed. RP JANUSZKIEWICZ, AJ (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT RESP RES,DIV MED,WASHINGTON,DC 20307, USA. NR 37 TC 9 Z9 10 U1 1 U2 1 PU ELSEVIER SCI IRELAND LTD PI CLARE PA CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE, IRELAND SN 0300-483X J9 TOXICOLOGY JI Toxicology PD MAY 20 PY 1994 VL 89 IS 3 BP 279 EP 300 DI 10.1016/0300-483X(94)90101-5 PG 22 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA NU842 UT WOS:A1994NU84200006 PM 8023332 ER PT J AU DUBEY, M JONES, KA ECKART, DW CASAS, LM PFEFFER, RL AF DUBEY, M JONES, KA ECKART, DW CASAS, LM PFEFFER, RL TI GROWTH OF SINGLE-CRYSTAL GE FILMS ON GAAS AND INGAP AND HIGHLY ORIENTED AU FILMS ON GE SO APPLIED PHYSICS LETTERS LA English DT Article ID OHMIC CONTACT; LOW-TEMPERATURE; MICROSTRUCTURE AB Single crystal germanium films were deposited on (100) GaAs and InGaP substrates, and highly oriented gold films were deposited on the germanium films by ultrahigh vacuum E-beam evaporation. They were characterized by double crystal x-ray diffraction (DXRD), transmission electron microscopy (TEM), Rutherford backscattering spectroscopy (RBS), Auger electron spectroscopy (AES), and scanning electron microscopy (SEM). The germanium film grew epitaxially with a smooth, abrupt interface, and the highly oriented gold film formed a smooth interface with the germanium and had a (100)Au parallel-to (100)Ge and (001)Au parallel-to [011]Ge or [001]Au parallel-to [0-1 1]Ge orientation relationship. Large grains with one or the other orientation relationship could be distinguished in the SEM. TEM micrographs show that the grains have a periodic dislocation pattern indicative of heteroepitaxy, and the grain boundaries appear to have a low energy. No contamination was detected in the gold film away from the interface with the germanium, and there was significant channeling of the RBS beam when it was normal to the gold film. RP DUBEY, M (reprint author), USA,RES LAB,EPSD,FT MONMOUTH,NJ 07703, USA. RI Schaff, William/B-5839-2009 NR 10 TC 9 Z9 9 U1 0 U2 8 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD MAY 16 PY 1994 VL 64 IS 20 BP 2697 EP 2699 DI 10.1063/1.111495 PG 3 WC Physics, Applied SC Physics GA NL618 UT WOS:A1994NL61800027 ER PT J AU ZAVADA, JM WILSON, RG ABERNATHY, CR PEARTON, SJ AF ZAVADA, JM WILSON, RG ABERNATHY, CR PEARTON, SJ TI HYDROGENATION OF GAN, ALN, AND INN SO APPLIED PHYSICS LETTERS LA English DT Article ID NITRIDES AB Hydrogen incorporation depths of greater-than-or-equal-to 1 mum are measured for H-2 plasma exposure of GaN and AlN at 250-400-degrees-C for 30 min. The concentration of H-2 incorporated is in the range 5-10X10(17) cm-3 for GaN and 5-30X10(18) cm-3 for AlN under these conditions. No redistribution of the hydrogen is observed for annealing temperatures up to 800-degrees-C, but at 900-degrees-C there is substantial loss of hydrogen from the samples. Similar results are obtained for H-2 implantation into GaN, AlN, and InN, with no significant redistribution observed up to 500-600-degrees-C in either AlN or InN, and motion only at 900-degrees-C in GaN. The thermal stability of hydrogen in III-V nitrides explains previous results for Mg-doped GaN grown using NH3, where post-growth annealing at high temperatures was required to achieve appreciable doping efficiencies. C1 HUGHES RES LABS, MALIBU, CA 90265 USA. UNIV FLORIDA, DEPT MAT SCI & ENGN, GAINESVILLE, FL 32611 USA. RP USA, RES OFF, RES TRIANGLE PK, NC 27709 USA. NR 24 TC 60 Z9 60 U1 1 U2 12 PU AMER INST PHYSICS PI MELVILLE PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA SN 0003-6951 EI 1077-3118 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD MAY 16 PY 1994 VL 64 IS 20 BP 2724 EP 2726 DI 10.1063/1.111455 PG 3 WC Physics, Applied SC Physics GA NL618 UT WOS:A1994NL61800036 ER PT J AU MAZZOLA, MS SADDOW, SE NEUDECK, PG LAKDAWALA, VK WE, S AF MAZZOLA, MS SADDOW, SE NEUDECK, PG LAKDAWALA, VK WE, S TI OBSERVATION OF THE D-CENTER IN 6H-SIC P-N DIODES GROWN BY CHEMICAL-VAPOR-DEPOSITION SO APPLIED PHYSICS LETTERS LA English DT Article ID SPECTROSCOPY AB The D-center in 6H-SiC is a boron-related deep hole trap observed previously in LPE-grown 6H-SiC diodes. We report deep level transient spectroscopy (DLTS) measurements in which the D-center signature is observed in high-purity n- and p-type epitaxial layers formed by chemical vapor deposition (CVD). An activation energy of 0.58 eV and a capture cross section between 1X10(-14) cm2 and 3X10(-14) cm2 was determined for this level. Even though the D-center in these diodes is thought to arise from unintended trace contamination, we observed within the same diode a factor of twenty greater density of this level in the n -type layer than in the p-type layer, which is explained by a recently proposed site competition model for impurity doping during 6H-SiC CVD growth. C1 AMSRL WT NF,ARMY RES LAB,ADELPHI,MD 20783. NASA,LEWIS RES CTR,CLEVELAND,OH 44135. OLD DOMINION UNIV,DEPT ELECT & COMP ENGN,NORFOLK,VA 23529. RP MAZZOLA, MS (reprint author), MISSISSIPPI STATE UNIV,DEPT ELECT & COMP ENGN,MISSISSIPPI STATE,MS 39762, USA. NR 8 TC 35 Z9 35 U1 0 U2 3 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD MAY 16 PY 1994 VL 64 IS 20 BP 2730 EP 2732 DI 10.1063/1.111457 PG 3 WC Physics, Applied SC Physics GA NL618 UT WOS:A1994NL61800038 ER PT J AU THOMPSON, BA BLOUNT, BW KRUMHOLZ, TS AF THOMPSON, BA BLOUNT, BW KRUMHOLZ, TS TI TREATMENT APPROACHES TO BRUXISM SO AMERICAN FAMILY PHYSICIAN LA English DT Article AB Bruxism, or the grinding and clenching of teeth, occurs in approximately 15 percent of children and in as many as 96 percent of adults. The etiology of bruxism is unclear, but the condition has been associated with stress, occlusal disorders, allergies and sleep positioning. Because of its nonspecific pathology, bruxism may be difficult to diagnose. In addition to complaints from sleep partners, signs of teeth grinding include masticatory pain or fatigue, headaches, tooth sensitivity and attrition, oral infection and temporomandibular joint disorders. Signs of bruxism include tooth wear and mobility, as well as tender or hypertrophied masticatory muscles and joints. Children with bruxism are usually managed with observation and reassurance. Adults may be managed with stress reduction therapy, alteration of sleep positioning, drug therapy, biofeedback training, physical therapy and dental evaluation. If significant tooth attrition, mobility or fracture occurs, dental referral is mandatory. RP THOMPSON, BA (reprint author), USA,WOMACK ARMY MED CTR,FT BRAGG,NC 28307, USA. NR 0 TC 21 Z9 21 U1 1 U2 7 PU AMER ACAD FAMILY PHYSICIANS PI KANSAS CITY PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 SN 0002-838X J9 AM FAM PHYSICIAN JI Am. Fam. Physician PD MAY 15 PY 1994 VL 49 IS 7 BP 1617 EP 1622 PG 6 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA NM846 UT WOS:A1994NM84600006 PM 8184796 ER PT J AU MORAN, CA SUSTER, S ASKIN, FB KOSS, MN AF MORAN, CA SUSTER, S ASKIN, FB KOSS, MN TI BENIGN AND MALIGNANT SALIVARY GLAND-TYPE MIXED TUMORS OF THE LUNG - CLINICOPATHOLOGICAL AND IMMUNOHISTOCHEMICAL STUDY OF 8 CASES SO CANCER LA English DT Article DE MIXED TUMORS OF SALIVARY GLANDS; PLEOMORPHIC ADENOMAS; SALIVARY GLAND-TYPE LUNG TUMORS; IMMUNOHISTOCHEMISTRY; MALIGNANT MIXED TUMORS ID PLEOMORPHIC ADENOMA; MUCOEPIDERMOID CARCINOMA; MYOEPITHELIAL CELLS; BREAST; FEATURES; BRONCHUS; PROTEIN AB Background. Primary lung tumors showing features of salivary gland-type neoplasms are extremely rare. Methods. Eight patients with primary lung neoplasms showing light microscopic and immunohistochemical features of salivary gland-type mixed tumors were studied. Results. The patients were six women and two men, ages 35-69 years (mean, 52.5 years). The tumors ranged from 2 to 16 cm in greatest diameter. In two patients the lesions presented as polypoid endobronchial lesions obstructing the lumen; in another two patients the lesions were found in close proximity or in continuity with a bronchus; in three patients, the lesions presented as peripheral parenchymatous nodules unrelated to a bronchus; and in one patient, the relationship to the bronchus could not be determined. Histologically, the lesions were biphasic, showing admixtures in varying proportions of epithelial elements containing a predominant myoepithelial cell population with a stromal component containing an abundant myxoid or focally chondroid matrix. Immunohistochemical studies showed strong positivity of the cells in the epithelial component with low molecular weight keratins (CAM 5.2), and to a lesser extent with broad spectrum keratin, actin, and vimentin antibodies. The cells also showed variable reactivity in the epithelial and nonepithelial elements with S-100 protein and glial fibrillary acidic protein. Six tumors were grossly and histologically benign; in two patients, the tumors were larger, locally invasive, and showed more atypical histologic features. All patients were treated with surgical excision. On follow-up, of the six patients with histologically benign-appearing tumors, one was alive and well 6 years after surgery; another died 4 years after surgery of a second unrelated malignancy; one died during the immediate postoperative period of myocardial infarction; and three have been lost to follow-up. In the two patients with histologically atypical lesions, the tumors recurred and metastasized after 2 and 3 years, respectively, with one of them leading to death caused by widespread metastases and superior vena cava syndrome. Conclusions. Review of the literature and the findings in the current series indicate that salivary gland-type mixed tumors of the lung may present with a spectrum of histologic features and clinical behavior, ranging from benign to frankly malignant, similar to that observed for their salivary gland counterparts, Size of the lesion at the time of presentation, extent of local infiltration, and degree of mitotic activity appear to be the most reliable prognostic features of these tumors. C1 MT SINAI MED CTR,DEPT PATHOL & LAB MED,MIAMI BEACH,FL 33140. UNIV MIAMI,MT SINAI MED CTR,SCH MED,MIAMI BEACH,FL 33140. JOHNS HOPKINS UNIV,SCH MED,DEPT PATHOL,BALTIMORE,MD 21205. RP MORAN, CA (reprint author), USA,INST PATHOL,DEPT PULM & MEDIASTINAL PATHOL,WASHINGTON,DC 20306, USA. NR 34 TC 52 Z9 55 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0008-543X J9 CANCER JI Cancer PD MAY 15 PY 1994 VL 73 IS 10 BP 2481 EP 2490 DI 10.1002/1097-0142(19940515)73:10<2481::AID-CNCR2820731006>3.0.CO;2-A PG 10 WC Oncology SC Oncology GA NL993 UT WOS:A1994NL99300005 PM 7513602 ER PT J AU PEOPLES, GE YOSHINO, I DOUVILLE, CC ANDREWS, JVR GOEDEGEBUURE, PS EBERLEIN, TJ AF PEOPLES, GE YOSHINO, I DOUVILLE, CC ANDREWS, JVR GOEDEGEBUURE, PS EBERLEIN, TJ TI TCR V-BETA-3(+) AND V-BETA-6(+) CTL RECOGNIZE TUMOR-ASSOCIATED ANTIGENS RELATED TO HER2/NEU EXPRESSION IN HLA-A2(+) OVARIAN CANCERS SO JOURNAL OF IMMUNOLOGY LA English DT Article ID T-CELL RECEPTOR; BETA-GENE USAGE; HUMAN METASTATIC MELANOMAS; CYTOLYTIC LYMPHOCYTES-T; INFILTRATING LYMPHOCYTES; AUTOLOGOUS TUMOR; CHAIN; ACTIVATION; INTERLEUKIN-2; SPECIFICITY AB We have recently shown that HLA-A2-restricted, tumor-specific CTL can be isolated from tumor-infiltrating lymphocytes (TIL) in ovarian cancer, and that the sensitivity of ovarian tumors to these CTL is correlated with HER2/ neu expression. Furthermore, utilizing PCR, we have documented previously that V beta 2, V beta 3, V beta 6, and V beta 7 are represented in increased proportions in ovarian tumor-specific CTL lines. Therefore, to correlate the interaction of these specific TCR V beta segments with the HLA-A2 molecule and potential tumor-associated Ags (TAA) related to HER2/neu expression, we have utilized available mAbs to V beta 2, V beta 3, and V beta 6. We found that V beta 2(+), V beta 3(+), and V beta 6(+) CTL mediate antitumor activity, and a combination of these mAbs resulted in 83 to 95% inhibition of the cytotoxicity against autologous tumor from three separate patients. These mAbs also were capable of blocking HLA-A2-matched allogeneic cytotoxicity, suggesting that all three V beta families recognize TAA in the context of HLA-A2. An HLA-A2(+) melanoma was transfected with the HER2/neu gene and became sensitive to HLA-A2(+) ovarian cancer-specific CTL lysis. This cytotoxicity was mediated by V beta 3(+) and V beta 6(+) CTL, as demonstrated by mAb-blocking studies. FACS-depletion studies confirmed that CTL populations depleted of V beta 3 or V beta 6 no longer could recognize the HER2/neu transfectant. We conclude that V beta 3 and V beta 6 recognize some TAA that are either derived from the HER2/neu protein or induced by the expression of the HER2/neu gene and presented in the context of HLA-A2. Furthermore, V beta 2 seems to recognize an HER2/neu-unrelated Ag system also presented by HLA-A2. C1 HARVARD UNIV,BRIGHAM & WOMENS HOSP,SCH MED,DEPT SURG,DIV SURG ONCOL,BOSTON,MA 02115. USA,DEPT MED,STUDENT DETACHMENT,FT SAM HOUSTON,TX 78234. FU NCI NIH HHS [R01 CA45484, R01 CA09535] NR 34 TC 36 Z9 38 U1 0 U2 0 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD MAY 15 PY 1994 VL 152 IS 10 BP 4993 EP 4999 PG 7 WC Immunology SC Immunology GA NK925 UT WOS:A1994NK92500028 PM 7909829 ER PT J AU ZIELINSKI, GA MAYEWSKI, PA MEEKER, LD WHITLOW, S TWICKLER, MS MORRISON, M MEESE, DA GOW, AJ ALLEY, RB AF ZIELINSKI, GA MAYEWSKI, PA MEEKER, LD WHITLOW, S TWICKLER, MS MORRISON, M MEESE, DA GOW, AJ ALLEY, RB TI RECORD OF VOLCANISM SINCE 7000-BC FROM THE GISP2 GREENLAND ICE CORE AND IMPLICATIONS FOR THE VOLCANO-CLIMATE SYSTEM SO SCIENCE LA English DT Article ID ERUPTIONS; CHEMISTRY; IMPACT; AEROSOLS; SHEET; RINGS; SNOW AB Sulfate concentrations from continuous biyearly sampling of the GISP2 Greenland ice core provide a record of potential climate-forcing volcanism since 7000 B.C. Although 85 percent of the events recorded over the last 2000 years were matched to documented volcanic eruptions, only about 30 percent of the events from 1 to 7000 B.C. were matched to such events. Several historic eruptions may have been greater sulfur producers than previously thought. There are three times as many events from 5000 to 7000 B.C. as over the last two millennia with sulfate deposition equal to or up to five times that of the largest known historical eruptions. This increased volcanism in the early Holocene may have contributed to climatic cooling. C1 USA,COLD REG RES & ENGN LAB,HANOVER,NH 03755. PENN STATE UNIV,CTR EARTH SYST SCI,UNIV PK,PA 16802. PENN STATE UNIV,DEPT GEOSCI,UNIV PK,PA 16802. RP ZIELINSKI, GA (reprint author), UNIV NEW HAMPSHIRE,INST STUDY EARTH OCEANS & SPACE,GLACIER RES GRP,DURHAM,NH 03824, USA. NR 47 TC 305 Z9 325 U1 2 U2 43 PU AMER ASSOC ADVANCEMENT SCIENCE PI WASHINGTON PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 SN 0036-8075 J9 SCIENCE JI Science PD MAY 13 PY 1994 VL 264 IS 5161 BP 948 EP 952 DI 10.1126/science.264.5161.948 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA NK974 UT WOS:A1994NK97400030 PM 17830082 ER PT J AU DAVIS, DM HARDEN, CS SHOFF, DB BELL, SE EICEMAN, GA EWING, RG AF DAVIS, DM HARDEN, CS SHOFF, DB BELL, SE EICEMAN, GA EWING, RG TI ANALYSIS OF ION MOBILITY SPECTRA FOR MIXED VAPORS USING GAUSSIAN DECONVOLUTION SO ANALYTICA CHIMICA ACTA LA English DT Article DE MASS SPECTROMETRY; ION MOBILITY SPECTROMETRY; GAUSSIAN DECONVOLUTION ID PEAK SHAPE-ANALYSIS; PLASMA CHROMATOGRAPHY; SPECTROMETRY AB A central issue in the utilization of ion mobility spectrometry or chemical analysis is the proper interpretation of ion mobility spectra and the assignment of peak identities. Ion mobility spectra for contemporary drift tubes generally produce broad peaks and simple patterns without obvious details associated with structures. These features can hinder the analyses of spectra derived from mixed vapors. However, additional information from such spectra can be extracted through Gaussian deconvolutions. A deconvolution algorithm was examined for sensitivity toward parameters and for boundaries of operation using ion mobility spectra from binary mixtures. An ion-molecule cluster ion, not obvious in traditional spectra analysis, was disclosed by deconvolution analysis and confirmed by independent ion mobility spectrometry-mass spectrometry. C1 NEW MEXICO STATE UNIV,DEPT CHEM & BIOCHEM,LAS CRUCES,NM 88003. RP DAVIS, DM (reprint author), USA,CTR EDGEWOOD RES DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010, USA. NR 27 TC 2 Z9 2 U1 0 U2 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0003-2670 J9 ANAL CHIM ACTA JI Anal. Chim. Acta PD MAY 10 PY 1994 VL 289 IS 3 BP 263 EP 272 DI 10.1016/0003-2670(94)90002-R PG 10 WC Chemistry, Analytical SC Chemistry GA NK024 UT WOS:A1994NK02400002 ER PT J AU KOENIG, ML ROTHBARD, PM DECOSTER, MA MEYERHOFF, JL AF KOENIG, ML ROTHBARD, PM DECOSTER, MA MEYERHOFF, JL TI N-ACETYL-ASPARTYL-GLUTAMATE (NAAG) ELICITS RAPID INCREASE IN INTRANEURONAL CA2+ IN-VITRO SO NEUROREPORT LA English DT Article DE N-ACETYL-ASPARTYLGLUTAMATE; NAAG; CALCIUM; CA2+; INDO-1; FLUE-3; GLUTAMATE; MAGNESIUM; 2-AMINO-5-PHOSPHONOVALERATE (APV); EPILEPSY ID RAT-BRAIN; ACETYLASPARTYLGLUTAMATE; NEURONS; INVIVO; CATABOLISM; RECEPTOR; INVITRO; ENZYME AB N-ACETYL-ASPARTYLGLUTAMATE (NAAG) is an acidic dipeptide found at high concentrations almost exclusively in the brain and spinal cord. There is evidence that NAAG is an excitatory neurotransmitter/neuromodulator. On the other hand, the identification and characterization of an enzyme in the nervous system which hydrolyzes NAAG to liberate glutamic acid (Glu) has led to an alternative hypothesis that the dipeptide might serve as a precursor of the excitatory amino acid. Using an interactive laser cytometer to quantitate changes in intraneuronal Ca2+ in individual neurons, we demonstrate that NAAG, at the concentrations at which it is found in the brain, promotes a rapid increase in intraneuronal Ca2+. NAAG-induced effects are completely dependent on the presence of Ca2+ in the bathing medium and are inhibited by NMDA receptor and channel antagonists. Several factors have led us to conclude that it is NAAG itself, and not NAAG-derived Glu, which is responsible for the observed effects in this system. RP KOENIG, ML (reprint author), WALTER REED ARMY MED CTR,DEPT MED NEUROSCI,DIV NEUROPSYCHIAT,WASHINGTON,DC 20307, USA. NR 25 TC 26 Z9 26 U1 0 U2 1 PU RAPID SCIENCE PUBLISHERS PI LONDON PA 2-6 BOUNDARY ROW, LONDON, ENGLAND SE1 8NH SN 0959-4965 J9 NEUROREPORT JI Neuroreport PD MAY 9 PY 1994 VL 5 IS 9 BP 1063 EP 1068 DI 10.1097/00001756-199405000-00012 PG 6 WC Neurosciences SC Neurosciences & Neurology GA NN159 UT WOS:A1994NN15900012 PM 8080959 ER PT J AU INNIS, BL SNITBHAN, R KUNASOL, P LAORAKPONGSE, T POOPATANAKOOL, W KOZIK, CA SUNTAYAKORN, S SUKNUNTAPONG, T SAFARY, A TANG, DB BOSLEGO, JW AF INNIS, BL SNITBHAN, R KUNASOL, P LAORAKPONGSE, T POOPATANAKOOL, W KOZIK, CA SUNTAYAKORN, S SUKNUNTAPONG, T SAFARY, A TANG, DB BOSLEGO, JW TI PROTECTION AGAINST HEPATITIS-A BY AN INACTIVATED VACCINE SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Article ID A VIRUS; EPIDEMIC; TABLES AB Objective.-To evaluate the safety and efficacy of a new inactivated hepatitis A vaccine. Design.-Double-blind randomized controlled trial stratified by community. Setting.-Community-based in Thailand. Study Participants.-A total of 40119 children, aged 1 to 16 years, attending 148 primary schools: 38157 (95%) entered surveillance a mean of 138 days after receiving vaccine dose 1; 33586 (84%) completed the controlled trial of 532 days; and 31075 (81%) received crossover vaccine and remained under surveillance until day 844. Intervention.-Participants received hepatitis A vaccine or control hepatitis B vaccine starting January 7, 1991 (doses in months 0, 1, and 12), and crossed over to the alternate vaccine 18 months later. Main Outcome Measure.-Cases of hepatitis A (symptoms, alanine aminotransferase levels of 45 U/L or higher, and IgM to hepatitis A virus) were identified by evaluating school absences of 2 or more days. Results.-There were no serious adverse reactions despite administration of more than 109 000 doses of hepatitis A vaccine. Among initially seronegative recipients of two doses of hepatitis A vaccine, the proportion with 20 mlU/mL or more of antibody to hepatitis A virus before and 5 months after a 1-year booster was 94% and 99%, respectively. Of 6976 episodes of illness during the controlled trial, there were 40 cases of hepatitis A; 38 were in the control group. Of the 40 cases, six, all in controls, occurred after the 1-year booster dose. Following two doses of hepatitis A vaccine (days 138 through 386), protective efficacy was 94% (95% confidence interval, 79% to 99%); cumulative efficacy including the postbooster period (days 138 to 532) was 95% (95% confidence interval, 82% to 99%). The two hepatitis A vaccine recipients who had symptomatic infections (257 and 267 days after dose 1) appeared to have been partially protected since their illnesses were brief and associated with only slight increases in alanine aminotransferase. Conclusions.-Inactivated hepatitis A vaccine is safe; when administered in two doses, it protects against hepatitis A for at least 1 year. C1 ARMED FORCES RES INST MED SCI,USA MED COMPONENT,DEPT VIROL,BANGKOK,THAILAND. MINIST PUBL HLTH,DEPT COMMUNICABLE DIS CONTROL,BANGKOK,THAILAND. KAMPHAENG PHET PROV HOSP,KAMPHAENG PHET,THAILAND. KAMPHAENG PHET PROV PUBL HLTH OFF,KAMPHAENG PHET,THAILAND. SMITHKLINE BEECHAM BIOL,RIXENSART,BELGIUM. RP INNIS, BL (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DIV BIOMETR,WASHINGTON,DC 20307, USA. NR 25 TC 296 Z9 307 U1 0 U2 5 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD MAY 4 PY 1994 VL 271 IS 17 BP 1328 EP 1334 DI 10.1001/jama.271.17.1328 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA NH487 UT WOS:A1994NH48700024 PM 8158817 ER PT J AU DICK, WD MCMURRY, PH BOTTIGER, JR AF DICK, WD MCMURRY, PH BOTTIGER, JR TI SIZE-DEPENDENT AND COMPOSITION-DEPENDENT RESPONSE OF THE DAWN-A MULTIANGLE SINGLE-PARTICLE OPTICAL-DETECTOR SO AEROSOL SCIENCE AND TECHNOLOGY LA English DT Article ID LIGHT-SCATTERING; REFRACTIVE-INDEX; FLOW AB The performance of the DAWN-A differential light-scattering detector (Wyatt et al., 1988. Appl. Opt. 27:217-221) was characterized in laboratory experiments. Objectives of this work included measurement of size-dependent counting efficiencies and of angular scattering patterns for spherical particles of known size and composition. Counting efficiencies for polystyrene latex (PSL) spheres of nine sizes in the 0.14-0.97-mum diameter range were obtained as a function of the trigger threshold level. Counting efficiencies were found to increase with increasing particle size and decreasing trigger threshold level. Maximum observed counting efficiencies were in the range of 50% to 60%, indicating that the half-width of the laser beam was about a factor of 2 narrower than the width of the particle beam in the scattering volume. A distribution of pulse heights was observed for particles of a given size, reflecting the variability of the illumination intensity. Angular scattering patterns of PSL, dioctyl sebacate (DOS), and methylene blue for nine different sizes in the 0.14-0.97-mum size range were obtained; measurements were also done with 0.55-mum (at 7% relative humidity) sulfuric acid droplets exposed to eight different relative humidities in the 7% to 81% range. The PSL data were used to calibrate the detectors. For the other materials, Lorenz-Mie theory was used to determine the ''best'' value of the complex refractive index to match measurements to theory for each particle size investigated. For sulfuric acid, the inferred imaginary component of refractive index was zero as expected, while the real component was within 2% of the literature value over the range of relative humidities investigated. For DOS (expected value = 1.46 + 0.00i), the inferred real component of refractive index was, on average, 4% greater than the expected value, and the average inferred imaginary component was 0.02 for particles >0.32 mum. Small signal-to-noise led to poor agreement between theory and measurement for 0.14-mum particles. For methylene blue, which has a nonzero imaginary component (expected value = 0.82 + 0.40i), there were large uncertainties in the inferred refractive index values due to problems in generating spherical, homogeneous particles. C1 UNIV MINNESOTA, DEPT MECH ENGN, PARTICLE TECH LAB, 111 CHURCH ST SE, MINNEAPOLIS, MN 55455 USA. USA, EDGEWOOD RES DEV & ENGN CTR, ABERDEEN PROVING GROUND, MD 21010 USA. RI McMurry, Peter/A-8245-2008 OI McMurry, Peter/0000-0003-1609-5131 NR 35 TC 19 Z9 19 U1 0 U2 1 PU TAYLOR & FRANCIS INC PI PHILADELPHIA PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA SN 0278-6826 EI 1521-7388 J9 AEROSOL SCI TECH JI Aerosol Sci. Technol. PD MAY PY 1994 VL 20 IS 4 BP 345 EP 362 DI 10.1080/02786829408959690 PG 18 WC Engineering, Chemical; Engineering, Mechanical; Environmental Sciences; Meteorology & Atmospheric Sciences SC Engineering; Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA NH798 UT WOS:A1994NH79800005 ER PT J AU LOUWAGIE, J DELWART, EL MULLINS, JI MCCUTCHAN, FE EDDY, G BURKE, DS AF LOUWAGIE, J DELWART, EL MULLINS, JI MCCUTCHAN, FE EDDY, G BURKE, DS TI GENETIC-ANALYSIS OF HIV-1 ISOLATES FROM BRAZIL REVEALS PRESENCE OF 2 DISTINCT GENETIC SUBTYPES SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Article AB The spread of the human immunodeficiency virus type 1 (HIV-1) is by now virtually worldwide. An understanding of the genetic, biological, and immunological differences among isolates collected in different geographic locales is crucial for the development of globally effective vaccines. Here we report the genetic characteristics of 21 HIV-1 isolates from Brazil. The isolates were initially characterized using a heteroduplex mobility assay. The majority (17 of 21) were related to North American/European reference isolates of genetic subtype B. Four isolates belonged to a more recently identified genotype, termed subtype F. The subtype F sequences from Brazil are distinguishable in both gag and env from five other genetic subtypes of HIV-1 currently recognized. Like many locales, Brazil harbors more than one HIV-1 subtype. C1 HENRY M JACKSON FDN,RES LAB,ROCKVILLE,MD 20850. STANFORD UNIV,SCH MED,DEPT IMMUNOL & MICROBIOL,STANFORD,CA 94305. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,WASHINGTON,DC 20307. MIL MED CONSORTIUM APPL RETROVIRAL RES,WASHINGTON,DC 20306. OI Delwart, Eric/0000-0002-6296-4484; /0000-0002-5704-8094 FU NIAID NIH HHS [AI32885] NR 24 TC 91 Z9 92 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD MAY PY 1994 VL 10 IS 5 BP 561 EP 567 DI 10.1089/aid.1994.10.561 PG 7 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA NR146 UT WOS:A1994NR14600008 PM 7917518 ER PT J AU REID, TJ MULLANEY, M BURRELL, LM REDMOND, J MANGAN, KF AF REID, TJ MULLANEY, M BURRELL, LM REDMOND, J MANGAN, KF TI PURE RED-CELL APLASIA AFTER CHEMOTHERAPY FOR HODGKINS LYMPHOMA - IN-VITRO EVIDENCE FOR T-CELL MEDIATED SUPPRESSION OF ERYTHROPOIESIS AND RESPONSE TO SEQUENTIAL CYCLOSPORINE AND ERYTHROPOIETIN SO AMERICAN JOURNAL OF HEMATOLOGY LA English DT Article DE HODGKINS DISEASE; RED-CELL APLASIA, PURE; CYCLOSPORINE A; ERYTHROPOIETIN; CHEMOTHERAPY; IMMUNOGLOBULINS, INTRAVENOUS ID CHRONIC LYMPHOCYTIC-LEUKEMIA; MONOCLONAL-ANTIBODIES; PATIENT; MARROW; GLOBULIN; DISEASE; SUBPOPULATIONS; PROLIFERATION; RADIOTHERAPY; RESOLUTION AB Acquired pure red cell aplasia (PRCA) has been associated with various lymphoproliferative conditions but its occurrence with Hodgkin's disease is rare. We report a case of PRCA occurring immediately following the completion of induction chemotherapy in a patient with Stage IIIB nodular sclerosing Hodgkin's disease. In vitro erythroid colony studies documented evidence for T cell mediated suppression of erythropoiesis and lack of a serum inhibitor. Addition of cyclosporin to the in vitro cultures stimulated erythroid colony growth. Following in vivo treatment with cyclosporin peripheral blood CD4/CD8 ratios returned to normal. However, serum erythropoietin levels were inappropriately low. Subsequent treatment with erythropoietin induced a reticulocytosis and transfusion independence. Since discontinuing the erythropoietin, the patient has been able to maintain a hemoglobin of 100 g/L. This case illustrates that red cell aplasia occurring in the setting of Hodgkin's disease may be due to T cell mediated suppression of erythropoiesis. A response to cyclosporin may be masked by inappropriately low erythropoietin levels. (C) 1994 Wiley-Liss, Inc. C1 TEMPLE UNIV,DEPT MED,PHILADELPHIA,PA. WALTER REED ARMY MED CTR,DEPT MED,HEMATOL ONCOL SERV,WASHINGTON,DC 20307. RP REID, TJ (reprint author), WALTER REED ARMY MED INST RES,DEPT HEMATOL,WASHINGTON,DC 20307, USA. FU NCI NIH HHS [CA 26806] NR 30 TC 16 Z9 16 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0361-8609 J9 AM J HEMATOL JI Am. J. Hematol. PD MAY PY 1994 VL 46 IS 1 BP 48 EP 53 DI 10.1002/ajh.2830460109 PG 6 WC Hematology SC Hematology GA NE019 UT WOS:A1994NE01900008 PM 8184875 ER PT J AU CHAN, DS SATO, AK CLAYBAUGH, JR AF CHAN, DS SATO, AK CLAYBAUGH, JR TI DEGRADATION OF CAPTOPRIL IN SOLUTIONS COMPOUNDED FROM TABLETS AND STANDARD POWDER SO AMERICAN JOURNAL OF HOSPITAL PHARMACY LA English DT Note ID STABILITY C1 UNIV PACIFIC,STOCKTON,CA 95211. UNIV HAWAII,JOHN A BURNS SCH MED,HONOLULU,HI 96822. TRIPLER ARMY MED CTR,DEPT CLIN INVEST,HONOLULU,HI 96859. RP CHAN, DS (reprint author), TRIPLER ARMY MED CTR,HSHK PY,SERV PHARM,HONOLULU,HI 96859, USA. NR 13 TC 5 Z9 5 U1 0 U2 0 PU AMER SOC HEALTH-SYSTEM PHARMACISTS PI BETHESDA PA 7272 WISCONSIN AVE, BETHESDA, MD 20814 SN 0002-9289 J9 AM J HOSP PHARM JI Am. J. Hosp. Pharm. PD MAY 1 PY 1994 VL 51 IS 9 BP 1205 EP 1207 PG 3 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA NJ944 UT WOS:A1994NJ94400010 PM 8042640 ER PT J AU REYNOLDS, KL HECKEL, HA WITT, CE MARTIN, JW POLLARD, JA KNAPIK, JJ JONES, BH AF REYNOLDS, KL HECKEL, HA WITT, CE MARTIN, JW POLLARD, JA KNAPIK, JJ JONES, BH TI CIGARETTE-SMOKING, PHYSICAL-FITNESS, AND INJURIES IN INFANTRY SOLDIERS SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Article AB Reliable data on the impact of physical training on light infantry units in terms of injuries and time loss are sparse. This study evaluated a light infantry unit (n = 181) prospectively and followed it throughout one year of infantry training and operations. Fifty-five percent of the soldiers (n = 101) experienced one or more injuries. Eighty-eight percent of the injuries were training-related conditions, which resulted in 1,103 days of limited duty. Lower extremity overuse injuries were the most common type of injury documented. Fractures accounted for the greatest number of days of limited duty. Risk factors for training-related injuries identified by this study were cigarette smoking, high percentage of body fat; extremely high or low body mass index, low endurance levels, and low muscular endurance levels (sit-ups). Logistic regression showed that cigarette smoking and low endurance levels were independent risk factors for training injuries. These data indicate that the incidence of training-related injuries in infantry units is high. A number of modifiable injury risk factors were identified, suggesting that many of these injuries may be preventable. RP REYNOLDS, KL (reprint author), USA,ENVIRONM MED RES INST,DIV OCCUPAT MED,NATICK,MA 01760, USA. NR 0 TC 79 Z9 82 U1 0 U2 3 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 SN 0749-3797 J9 AM J PREV MED JI Am. J. Prev. Med. PD MAY-JUN PY 1994 VL 10 IS 3 BP 145 EP 150 PG 6 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA NV554 UT WOS:A1994NV55400005 PM 7917440 ER PT J AU BEIER, JC OSTER, CN ONYANGO, FK BALES, JD SHERWOOD, JA PERKINS, PV CHUMO, DK KOECH, DV WHITMIRE, RE ROBERTS, CR DIGGS, CL HOFFMAN, SL AF BEIER, JC OSTER, CN ONYANGO, FK BALES, JD SHERWOOD, JA PERKINS, PV CHUMO, DK KOECH, DV WHITMIRE, RE ROBERTS, CR DIGGS, CL HOFFMAN, SL TI PLASMODIUM-FALCIPARUM INCIDENCE RELATIVE TO ENTOMOLOGIC INOCULATION RATES AT A SITE PROPOSED FOR TESTING MALARIA VACCINES IN WESTERN KENYA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID ANOPHELES-GAMBIAE COMPLEX; INFECTED ANOPHELES; KISUMU AREA; TRANSMISSION; SPOROZOITES; CULICIDAE; DIPTERA AB Relationships between Plasmodium falciparum incidence and entomologic inoculation rates (EIRs) were determined for a 21-month period in Saradidi, western Kenya, in preparation for malaria vaccine field trials. Children, ranging in age from six months to six years and treated to clear malaria parasites, were monitored daily for up to 12 weeks to detect new malaria infections. Overall, new P. falciparum infections were detected in 77% of 809 children. The percentage of children that developed infections per two-week period averaged 34.7%, ranging from 7.3% to 90.9%. Transmission by vector populations was detected in 86.4% (38 of 44) of the two-week periods, with daily EIRs averaging 0.75 infective bites per person. Periods of intense transmission during April to August, and from November to January, coincided with seasonal rains. Relationships between daily malaria attack rates and EIRs indicated that an average of only 7.5% (1 in 13) of the sporozoite inoculations produced new infections in children. Regression analysis demonstrated that EIRs accounted for 74% of the Variation in attack rates. One of the components of the EIR, the human-biting rate, alone accounted for 68% of the variation in attack rates. Thus, measurements of either the EIR or the human-biting rate can be used to predict corresponding attack rates in children. These baseline epidemiologic studies indicate that the intense transmission patterns of P. falciparum in Saradidi will provide excellent conditions for evaluating malaria vaccine efficacy. C1 KENYA GOVT MED RES CTR,NAIROBI,KENYA. USA,RESP MED UNIT,NAIROBI,KENYA. USN,MED RES INST,BETHESDA,MD. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT ENTOMOL,WASHINGTON,DC 20307. RP BEIER, JC (reprint author), JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,DEPT IMMUNOL & INFECT DIS,615 N WOLFE ST,BALTIMORE,MD 21205, USA. FU NIAID NIH HHS [AI-29000] NR 30 TC 173 Z9 174 U1 1 U2 7 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD MAY PY 1994 VL 50 IS 5 BP 529 EP 536 PG 8 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA NR407 UT WOS:A1994NR40700001 PM 7911282 ER PT J AU SHANKS, GD EDSTEIN, MD CHEDESTER, AL SMITH, CD CORCORAN, KD NGAMPOCHJANA, M HANSUKJARIYA, P SATTABONGKOT, J WEBSTER, HK AF SHANKS, GD EDSTEIN, MD CHEDESTER, AL SMITH, CD CORCORAN, KD NGAMPOCHJANA, M HANSUKJARIYA, P SATTABONGKOT, J WEBSTER, HK TI PROGUANIL PLUS SULFAMETHOXAZOLE IS NOT CAUSALLY PROPHYLACTIC IN THE MACACA-MULATTA PLASMODIUM-CYNOMOLGI MODEL SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID MALARIA PROPHYLAXIS; CYCLOGUANIL AB New drugs for causal prophylaxis of malaria are needed. A proguanil/sulfamethoxazole combination was investigated using a rhesus monkey model (Macaca mulatta infected with Plasmodium cynomolgi) to determine whether causal prophylaxis could be achieved. When a five-day regimen of proguanil (40 mg/kg/day) combined with sulfamethoxazole (100 mg/kg/day) was used, infection of all animals (6 of 6) was observed, with an extended prepatent period (median 40 days). Two control animals became infected on days 9 and 23 following sporozoite inoculation. Plasma concentrations indicated that proguanil and sulfamethoxazole were adequately absorbed and metabolized to cycloguanil and N-4-acetylsulfamethoxazole, respectively. Analysis of liver biopsy specimens demonstrated that the drugs were present two days following sporozoite inoculation but were not detectable one week later. Proguanil plus sulfamethoxazole does not eliminate exoerythrocytic-stage parasites in the rhesus monkey-P. cynomolgi model. C1 ARMED FORCES RES INST MED SCI,DEPT MED,BANGKOK 10400,THAILAND. ARMED FORCES RES INST MED SCI,DEPT IMMUNOL,BANGKOK 10400,THAILAND. ARMED FORCES RES INST MED SCI,DEPT VET MED,BANGKOK 10400,THAILAND. ARMED FORCES RES INST MED SCI,DEPT ENTOMOL,BANGKOK 10400,THAILAND. RI Shanks, George Dennis/F-4056-2014 OI Shanks, George Dennis/0000-0001-5763-8660 NR 15 TC 10 Z9 10 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD MAY PY 1994 VL 50 IS 5 BP 641 EP 645 PG 5 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA NR407 UT WOS:A1994NR40700018 PM 8203715 ER PT J AU COLEMAN, RE NATH, AK SCHNEIDER, I SONG, GH KLEIN, TA MILHOUS, WK AF COLEMAN, RE NATH, AK SCHNEIDER, I SONG, GH KLEIN, TA MILHOUS, WK TI PREVENTION OF SPOROGONY OF PLASMODIUM-FALCIPARUM AND P-BERGHEI IN ANOPHELES-STEPHENSI MOSQUITOS BY TRANSMISSION-BLOCKING ANTIMALARIALS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID SPORONTOCIDAL ACTIVITY; MALARIA; INVITRO; DRUG; ANKA AB The sporontocidal activity of three 8-aminoquinolines, a 1,4-naphthoquinone, and three dihydroacridine-diones was determined against the ANKA clone of Plasmodium berghei and both chloroquine-sensitive (NF54) and chloroquine-resistant (7G8) P. falciparum. Anopheles stephensi mosquitoes previously fed on P. berghei-infected mice or P. falciparum-infected cultures were refed on uninfected mice treated previously with a given drug. Sporontocidal activity was determined by assessing both oocyst and sporozoite development. Neither primaquine nor menoctone exhibited sporontocidal activity against P. berghei or either strain of P. falciparum at a dose of 100 mg base drug/kg mouse body weight, whereas the other five compounds each effectively interrupted the sporogonic development of all three parasite strains at this dose. These data clearly demonstrate that experimental dihydroacridine-diones and 8-aminoquinolines are capable of interrupting the sporogonic development of P. berghei and chloroquine-sensitive and chloroquine-resistant P. falciparum. These data also suggest that the P. berghei model may be used to accurately predict sporontocidal activity against P. falciparum. C1 WALTER REED ARMY INST RES,DEPT PARASITOL,WASHINGTON,DC. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT ENTOMOL,DIV COMMUNICABLE DIS & IMMUNOL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT PARASITOL,WASHINGTON,DC 20307. NR 21 TC 29 Z9 30 U1 0 U2 5 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD MAY PY 1994 VL 50 IS 5 BP 646 EP 653 PG 8 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA NR407 UT WOS:A1994NR40700019 PM 8203716 ER PT J AU NASEEM, SM CREASIA, DA AF NASEEM, SM CREASIA, DA TI OXIDATION OF SAXITOXIN - DETECTION AND BIOLOGICAL-ACTIVITY OF ITS REACTION-PRODUCTS SO BIOCHEMISTRY AND MOLECULAR BIOLOGY INTERNATIONAL LA English DT Article ID GONYAULAX TOXINS; SHELLFISH; HPLC RP NASEEM, SM (reprint author), USA,MED RES INST INFECT DIS,DIV TOXICOL,FREDERICK,MD 21702, USA. NR 15 TC 2 Z9 2 U1 1 U2 1 PU ACADEMIC PRESS AUST PI MARRICKVILLE PA LOCKED BAG 16, MARRICKVILLE NSW 2204, AUSTRALIA SN 1039-9712 J9 BIOCHEM MOL BIOL INT JI Biochem. Mol. Biol. Int. PD MAY PY 1994 VL 33 IS 1 BP 177 EP 186 PG 10 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA NP617 UT WOS:A1994NP61700021 PM 8081207 ER PT J AU SCHEFFER, R CORRENTI, EE BORISON, RL MUKHERJEE, S AF SCHEFFER, R CORRENTI, EE BORISON, RL MUKHERJEE, S TI PREMORBID HISTORY AND CLINICAL MANIFESTATIONS AT THE ONSET OF PSYCHOSIS SO BIOLOGICAL PSYCHIATRY LA English DT Meeting Abstract C1 DWIGHT D EISENHOWER AMRY MED CTR,DEPT PSYCHIAT & NEUROL,FT GORDON,GA 30905. MED COLL GEORGIA,DEPT PSYCHIAT,AUGUSTA,GA 30912. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0006-3223 J9 BIOL PSYCHIAT JI Biol. Psychiatry PD MAY 1 PY 1994 VL 35 IS 9 BP 695 EP 696 DI 10.1016/0006-3223(94)90947-4 PG 2 WC Neurosciences; Psychiatry SC Neurosciences & Neurology; Psychiatry GA NJ172 UT WOS:A1994NJ17200289 ER PT J AU MUKHERJEE, S MAHADIK, SP HORROBIN, DF JENKINS, K CORRENTI, EE SCHEFFER, R AF MUKHERJEE, S MAHADIK, SP HORROBIN, DF JENKINS, K CORRENTI, EE SCHEFFER, R TI MEMBRANE FATTY-ACID COMPOSITION OF FIBROBLASTS FROM SCHIZOPHRENIC-PATIENTS SO BIOLOGICAL PSYCHIATRY LA English DT Meeting Abstract C1 MED COLL GEORGIA,DEPT PSYCHIAT,AUGUSTA,GA 30912. EFAMOL RES INST,HALIFAX,NS,CANADA. DD EISENHOWER ARMY MED CTR,DEPT PSYCHIAT NEUROL,FT GORDON,GA. NR 0 TC 6 Z9 6 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0006-3223 J9 BIOL PSYCHIAT JI Biol. Psychiatry PD MAY 1 PY 1994 VL 35 IS 9 BP 700 EP 701 DI 10.1016/0006-3223(94)90966-0 PG 2 WC Neurosciences; Psychiatry SC Neurosciences & Neurology; Psychiatry GA NJ172 UT WOS:A1994NJ17200308 ER PT J AU MUKHERJEE, S MAHADIK, SP CORRENTI, EE SCHEFFER, R AF MUKHERJEE, S MAHADIK, SP CORRENTI, EE SCHEFFER, R TI THE ANTIOXIDANT DEFENSE SYSTEM AT THE ONSET OF PSYCHOSIS SO BIOLOGICAL PSYCHIATRY LA English DT Meeting Abstract C1 MED COLL GEORGIA,DEPT PSYCHIAT,AUGUSTA,GA 30912. DD EISENHOWER ARMY MED CTR,DEPT PSYCHIAT & NEUROL,FT GORDON,GA. NR 0 TC 12 Z9 12 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0006-3223 J9 BIOL PSYCHIAT JI Biol. Psychiatry PD MAY 1 PY 1994 VL 35 IS 9 BP 701 EP 701 PG 1 WC Neurosciences; Psychiatry SC Neurosciences & Neurology; Psychiatry GA NJ172 UT WOS:A1994NJ17200309 ER PT J AU SCHEFFER, R DIAMOND, BI BORISON, RL CORRENTI, EE MUKHERJEE, S AF SCHEFFER, R DIAMOND, BI BORISON, RL CORRENTI, EE MUKHERJEE, S TI LOW PLASMA HOMOVANILLIC-ACID (HVA) AT THE ONSET OF PSYCHOSIS SO BIOLOGICAL PSYCHIATRY LA English DT Meeting Abstract C1 DWIGHT D EISENHOWER ARMY MED CTR,DEPT PSYCHIAT & NEUROL,FT GORDON,GA 30905. MED COLL GEORGIA,DEPT PSYCHIAT,AUGUSTA,GA 30912. NR 0 TC 1 Z9 1 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0006-3223 J9 BIOL PSYCHIAT JI Biol. Psychiatry PD MAY 1 PY 1994 VL 35 IS 9 BP 701 EP 702 DI 10.1016/0006-3223(94)90969-5 PG 2 WC Neurosciences; Psychiatry SC Neurosciences & Neurology; Psychiatry GA NJ172 UT WOS:A1994NJ17200311 ER PT J AU SCHEFFER, R CORRENTI, EE BORISON, RL MUKHERJEE, S AF SCHEFFER, R CORRENTI, EE BORISON, RL MUKHERJEE, S TI TEMPORAL STABILITY OF NEUROLOGICAL SIGNS IN FIRST-EPISODE PSYCHOTIC-PATIENTS SO BIOLOGICAL PSYCHIATRY LA English DT Meeting Abstract C1 DWIGHT D EISENHOWER ARMY MED CTR,DEPT PSYCHIAT & NEUROL,FT GORDON,GA. MED COLL GEORGIA,DEPT PSYCHIAT,AUGUSTA,GA 30912. NR 0 TC 3 Z9 3 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0006-3223 J9 BIOL PSYCHIAT JI Biol. Psychiatry PD MAY 1 PY 1994 VL 35 IS 9 BP 715 EP 715 DI 10.1016/0006-3223(94)91019-7 PG 1 WC Neurosciences; Psychiatry SC Neurosciences & Neurology; Psychiatry GA NJ172 UT WOS:A1994NJ17200361 ER PT J AU GRAHAM, JS BRYANT, MA KIRKPATRICK, LJ MOLTRUP, DL AF GRAHAM, JS BRYANT, MA KIRKPATRICK, LJ MOLTRUP, DL TI STAINING MAST-CELLS FOR MORPHOMETRIC EVALUATION ON AN IMAGE-ANALYSIS SYSTEM SO BIOTECHNIC & HISTOCHEMISTRY LA English DT Article DE MAST CELLS; IMAGE ANALYSIS; MORPHOMETRY; INTERFERENCE FILTERS; HISTOLOGIC STAINING AB Multiple skin sections from three nonhuman primates (Macaca mulatta) and three hairless guinea pigs (Cavia porcellus) were stained with 12 different histologic stains to determine whether mast cells could be selectively stained for morphometric analysis using an image analysis system (IAS). Sections were first evaluated with routine light microscopy for mast cell granule staining and the intensity of background staining. Methylene blue-basic fuchsin and Unna's method for mast cells (polychrome methylene blue with differentiation in glycerine-ether) stained mast cell granules more intensely than background in both species. Toluidine blue-stained sections in the guinea pig yielded similar results. Staining of the nuclei of dermal connective tissue was enhanced with the methylene blue-basic fuchsin and toluidine blue stains. These two stains, along with the Unna's stain, were further evaluated on an IAS with and without various interference filters (400.5-700.5 nm wavelengths). In both the methylene blue-basic fuchsin and toluidine blue stained sections, mast cell granules and other cell nuclei were detected together by the IAS. The use of interference filters with these two stains did not distinguish mast cell granules from stained nuclei. Unna's stain was the best of the 12 stains evaluated because mast cell granule staining was strong and background staining was faint. This contrast was further enhanced by interference filters (500.5-539.5 nm) and allowed morphometric measurements of mast cells to be taken on the IAS without background interference. RP GRAHAM, JS (reprint author), USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010, USA. NR 9 TC 4 Z9 4 U1 1 U2 1 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 1052-0295 J9 BIOTECH HISTOCHEM JI Biotech. Histochem. PD MAY PY 1994 VL 69 IS 3 BP 121 EP 126 DI 10.3109/10520299409106273 PG 6 WC Biotechnology & Applied Microbiology; Cell Biology SC Biotechnology & Applied Microbiology; Cell Biology GA NL389 UT WOS:A1994NL38900001 PM 7520757 ER PT J AU NARAYAN, P LOWE, BA CARROLL, PR THOMPSON, IM AF NARAYAN, P LOWE, BA CARROLL, PR THOMPSON, IM TI NEOADJUVANT HORMONAL-THERAPY AND RADICAL PROSTATECTOMY FOR CLINICAL STAGE-C CARCINOMA OF THE PROSTATE SO BRITISH JOURNAL OF UROLOGY LA English DT Article DE PROSTATE CANCER; REGIONALLY-ADVANCED, HORMONAL THERAPY; DOWNSTAGING ID EXTERNAL BEAM IRRADIATION; TRANS-RECTAL ULTRASONOGRAPHY; TOTAL PERINEAL PROSTATECTOMY; RADIATION-THERAPY; FOLLOW-UP; DEFINITIVE IRRADIATION; LOCALIZED CARCINOMA; TUMOR-CONTROL; CANCER; ADENOCARCINOMA AB Objective To determine whether hormonal therapy prior to radical prostatectomy (neoadjuvant hormonal therapy) leads to improved results in patients with stage C prostate cancer. Patients and methods Thirty patients received neoadjuvant hormonal therapy for stage C carcinoma of the prostate. Eighteen patients who responded to treatment subsequently underwent extirpative surgery. Results Fourteen of the 30 patients (47%) were diagnosed as being downstaged to clinical stage B disease following therapy. No major complications occurred. Pathology staging revealed only three patients (10%) to have organ-confined disease after radical prostatectomy. Conclusions Neoadjuvant hormonal therapy prior to radical prostatectomy offers little probability of rendering patients with clinical stage C carcinoma of the prostate free of disease. Further investigation of the effcacy of this treatment should be accomplished in randomized trials. C1 BROOKE ARMY MED CTR,DEPT UROL,SAN ANTONIO,TX 78234. OREGON HLTH SCI UNIV,SAN ANTONIO,TX. UNIV CALIF SAN FRANCISCO,DEPT UROL,SAN FRANCISCO,CA 94143. NR 47 TC 16 Z9 16 U1 0 U2 0 PU BLACKWELL SCIENCE LTD PI OXFORD PA OSNEY MEAD, OXFORD, OXON, ENGLAND OX2 0EL SN 0007-1331 J9 BRIT J UROL JI Br. J. Urol. PD MAY PY 1994 VL 73 IS 5 BP 544 EP 548 DI 10.1111/j.1464-410X.1994.tb07641.x PG 5 WC Urology & Nephrology SC Urology & Nephrology GA NM354 UT WOS:A1994NM35400013 PM 8012777 ER PT J AU MCFARLAND, VA FELDHAUS, J ACE, LN BRANNON, JM AF MCFARLAND, VA FELDHAUS, J ACE, LN BRANNON, JM TI MEASURING THE SEDIMENT/ORGANISM ACCUMULATION FACTOR OF PCB-52 USING A KINETIC-MODEL SO BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY LA English DT Article ID BIOACCUMULATION; CONTAMINANTS; SEDIMENT C1 NE LOUISIANA UNIV,SCH PHARM,DEPT PHARMACEUT & MED CHEM,MONROE,LA 71209. RP MCFARLAND, VA (reprint author), USA,ENGINEER WATERWAYS EXPT STN,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 18 TC 7 Z9 7 U1 0 U2 0 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0007-4861 J9 B ENVIRON CONTAM TOX JI Bull. Environ. Contam. Toxicol. PD MAY PY 1994 VL 52 IS 5 BP 699 EP 705 PG 7 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA MY885 UT WOS:A1994MY88500011 PM 8186640 ER PT J AU MAXWELL, DM LIESKE, CN BRECHT, KM AF MAXWELL, DM LIESKE, CN BRECHT, KM TI OXIME-INDUCED REACTIVATION OF CARBOXYLESTERASE INHIBITED BY ORGANOPHOSPHORUS COMPOUNDS SO CHEMICAL RESEARCH IN TOXICOLOGY LA English DT Article ID ACETYLCHOLINESTERASE; SOMAN; HI-6; RAT AB A structure-activity analysis of the ability of oximes to reactivate rat plasma carboxylesterase (CaE) that was inhibited by organophosphorus (OP) compounds revealed that uncharged oximes, such as 2,3-butanedione monoxime (diacetylmonoxime) or monoisonitrosoacetone, were better reactivators than cationic oximes. Cationic oximes that are excellent reactivators of OP-inhibited acetylcholinesterase, such as pyridine-2-aldoxime or the bis-pyridine aldoximes, HI-6 and TMB-4, produced poor reactivation of OP-inhibited CaE. The best uncharged reactivator was 2,3-butanedione monoxime, which produced complete reactivation at 0.3 mM in 2 h of CaE that was inhibited by phosphinates, alkoxy-containing phosphates, and alkoxy-containing phosphonates. Complete reactivation of CaE could be achieved even after inhibition by phosphonates with highly branched alkoxy groups, such as sarin and soman, that undergo rapid aging with acetylcholinesterase. CaE that was inhibited by phosphonates or phosphates that contained aryloxy groups were reactivated to a lesser extent. The cause of this decreased reactivation appears to be an oxime-induced aging reaction that competes with the reactivation reaction. This oxime-induced aging reaction is accelerated by electron-withdrawing substituents on the aryloxy groups of phosphonates and by the presence of multiple aryloxy groups on phosphates. Thus, reactivation and aging of OP-inhibited CaE differ from the same processes for OP-inhibited acetylcholinesterase in both their oxime specificity and inhibitor specificity and, presumably, in their underlying mechanisms. RP MAXWELL, DM (reprint author), USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010, USA. NR 31 TC 15 Z9 15 U1 1 U2 4 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0893-228X J9 CHEM RES TOXICOL JI Chem. Res. Toxicol. PD MAY-JUN PY 1994 VL 7 IS 3 BP 428 EP 433 DI 10.1021/tx00039a022 PG 6 WC Chemistry, Medicinal; Chemistry, Multidisciplinary; Toxicology SC Pharmacology & Pharmacy; Chemistry; Toxicology GA NL680 UT WOS:A1994NL68000022 PM 8075376 ER PT J AU FAIRCLOTH, DN TENHOLDER, MF WHITLOCK, WL DOWNS, RH AF FAIRCLOTH, DN TENHOLDER, MF WHITLOCK, WL DOWNS, RH TI PULMONARY DYSFUNCTION SECONDARY TO MANDIBULAR RETROGNATHIA IN MARFANS-SYNDROME SO CHEST LA English DT Note ID OBSTRUCTIVE SLEEP-APNEA; AIRWAY AB Referrals to pulmonary physicians for polysomnography to evaluate snoring or the possibility of sleep apnea syndrome often evolve into a multidisciplinary clinical problem. We present a young woman with two congenital abnormalities (Marfan's syndrome and retrognathism) which both may affect her decreased exercise tolerance, daytime hypersomnolence, and fatigue. Polysomnography and pulmonary exercise testing documented improvement in her upper airway diameter and exercise capacity. Her improved sleep pattern and her understanding of her exercise performance limitations afforded her a new outlook on life. C1 VET ADM MED CTR,AUGUSTA,GA 30904. EISENHOWER ARMY MED CTR,FT GORDON,GA. BAYNE JONES ARMY HOSP,FT POLK,LA. RP FAIRCLOTH, DN (reprint author), MED COLL GEORGIA,AUGUSTA,GA 30912, USA. NR 16 TC 2 Z9 2 U1 0 U2 0 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 SN 0012-3692 J9 CHEST JI Chest PD MAY PY 1994 VL 105 IS 5 BP 1610 EP 1613 DI 10.1378/chest.105.5.1610 PG 4 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA NL392 UT WOS:A1994NL39200072 PM 8181376 ER PT J AU LUCEY, DR NOVAK, JM POLONIS, VR LIU, YL GARTNER, S AF LUCEY, DR NOVAK, JM POLONIS, VR LIU, YL GARTNER, S TI CHARACTERIZATION OF SUBSTANCE-P BINDING TO HUMAN MONOCYTES/MACROPHAGES SO CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY LA English DT Article ID HUMAN IMMUNODEFICIENCY VIRUS; ENZYME COMPLEX RECEPTOR; TACHYKININ NEUROPEPTIDES; HUMAN-MONOCYTES; CELLS; FUSION; MACROPHAGES; INTERLEUKIN-1; REPLICATION; ACTIVATION AB Substance P (SP), a member of the tachykinin family of neuropeptides, can immunomodulate human T cells and monocytes. SP has been shown to stimulate human monocytes to produce inflammatory cytokines and superoxide ions, and it enhances tumoricidal activity in vitro. A specific SP receptor, however, has not been identified on human monocytes/macrophages. In this study, we report that I-125-Sp binds to human monocytes/macrophages with high affinity and specificity (K-d = 2.7 x 10(-8) to 5.5 x 10(-8) M). Our measurements of binding affinity to this single class of receptors were possible only when experiments were performed in the presence of excess serine proteinase inhibitor (serpin) enzyme complex receptor ligand. We determined that I-125-Sp bound to a specific receptor on human monocytes/macrophages and that this binding was detectable as early as 6 h and was maintained throughout 6 to 8 weeks in culture. Modulation of the diverse immunological and inflammatory effects of SP on human monocytes may be mediated through this specific SP receptor. C1 WALTER REED ARMY MED CTR,DEPT RETROVIRAL RES,ROCKVILLE,MD 20850. HENRY M JACKSON FDN,ROCKVILLE,MD 20850. USA,MED RES INST INFECT DIS,DIV BACTERIOL,FT DETRICK,MD 21702. NR 40 TC 36 Z9 36 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 1071-412X J9 CLIN DIAGN LAB IMMUN JI Clin. Diagn. Lab. Immunol. PD MAY PY 1994 VL 1 IS 3 BP 330 EP 335 PG 6 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA PT564 UT WOS:A1994PT56400013 PM 7496971 ER PT J AU KATZ, N TONEY, MO HEIRONIMUS, JD SMITH, TE AF KATZ, N TONEY, MO HEIRONIMUS, JD SMITH, TE TI GASTRIC-EMPTYING - COMPARISON OF ANTERIOR ONLY AND GEOMETRIC MEAN CORRECTION METHODS EMPLOYING STATIC AND DYNAMIC IMAGING SO CLINICAL NUCLEAR MEDICINE LA English DT Article ID SOLID-FOOD; SCINTIGRAPHIC EVALUATION; STOMACH; ERRORS; LIQUID; PHASE; SIZE AB Dynamic (continuous) and static imaging techniques were compared in the analysis of gastric emptying patterns in 16 consecutive adult patients with normal gastric half-emptying times assessed by dynamic imaging for 90 minutes under a dual head camera allowing simultaneous anterior and posterior imaging. Gastric t1/2 values were calculated for each patient based on four different data analysis methods: geometric mean corrected dynamic data (GD), anterior alone dynamic data (AD), geometric mean corrected simulated static data (GS), and anterior alone simulated static data (AS). The mean t1/2 values were: GD = 63.8 minutes, AD = 72.1 minutes, GS = 65.3 minutes, and AS = 73.0 minutes. Both the geometric mean corrected methods had a statistically different t1/2 than either of the anterior methods. Lag phase measurements, defined as a 2% decrease in gastric activity were: GD = 7 minutes, AD = 19 minutes, GS = 6 minutes, and AS = 16 minutes. Dynamic and static geometric mean methods provide similar gastric t1/2 calculations that are statistically different than anterior alone methods, and the lag phase is much shorter using either of the geometric mean methods. RP KATZ, N (reprint author), BROOKE ARMY MED CTR,DEPT RADIOL,NUCL MED SERV,FT SAM HOUSTON,TX 78234, USA. NR 27 TC 5 Z9 5 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0363-9762 J9 CLIN NUCL MED JI Clin. Nucl. Med. PD MAY PY 1994 VL 19 IS 5 BP 396 EP 400 DI 10.1097/00003072-199405000-00004 PG 5 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA NK953 UT WOS:A1994NK95300004 PM 8039311 ER PT J AU TILLOTSON, G PHILIPPS, SG COKER, S DIFAZIO, M AF TILLOTSON, G PHILIPPS, SG COKER, S DIFAZIO, M TI EARLY DIAGNOSIS OF SPINAL-CORD ARTERIOVENOUS MALFORMATION IN A 7-YEAR-OLD CHILD SO CLINICAL PEDIATRICS LA English DT Note AB Spinal cord arteriovenous malformations (AVMs) are relatively uncommon in the pediatric age group.(1) Early diagnosis is rarely made and the resulting complications arising from the AVM may have devastating long lasting neurologic sequelae.(2) Early diagnosis requires a high degree of clinical suspicion. We report the case of spinal cord AVM in a child who presented with two episodes of ''neck stiffness'' without headache in whom the prompt diagnosis and treatment prevented neurologic sequelae. C1 LOYOLA UNIV,MED CTR,DEPT NEUROL,MAYWOOD,IL 60153. WALTER REED ARMY MED CTR,DEPT PEDIAT,WASHINGTON,DC 20307. RP TILLOTSON, G (reprint author), EDWARD HINES VET ADM MED CTR,DEPT NEUROL,HINES,IL 60141, USA. NR 7 TC 6 Z9 6 U1 0 U2 0 PU WESTMINSTER PUBL INC PI GLEN HEAD PA 708 GLEN COVE AVE, GLEN HEAD, NY 11545 SN 0009-9228 J9 CLIN PEDIATR JI Clin. Pediatr. PD MAY PY 1994 VL 33 IS 5 BP 315 EP 317 DI 10.1177/000992289403300516 PG 3 WC Pediatrics SC Pediatrics GA NM013 UT WOS:A1994NM01300013 PM 8050262 ER PT J AU OREY, M TRENT, A YOUNG, J SANDERS, M AF OREY, M TRENT, A YOUNG, J SANDERS, M TI DEVELOPMENT EFFICIENCY AND EFFECTIVENESS OF ALTERNATIVE PLATFORMS FOR INTELLIGENT TUTORING FOR THE MOBILE SUBSCRIBER RADIO-TELEPHONE TERMINAL SO COMPUTERS & EDUCATION LA English DT Article AB This paper examines the use of an off-the-shelf hypermedia package for the development of an Intelligent Tutoring System (ITS). There were two concerns in this regard: (1) can the off-the-shelf package reduce the development time; and (2) will people learn as well from an ITS that is developed with an off-the-shelf package as they would from an ITS using a programming language (the C language)? The answers to these questions are yes and not only as good, but better. It took a C programmer 2.4 times longer to create an ITS from the shell of another similar ITS than it took a Linkway(R) (an off-the-shelf hypermedia package) programmer to develop an ITS from scratch. The learning data indicated that the Linkway(R) version was much easier to learn and performance on a test problem indicated that the Linkway(R) group made significantly fewer errors than the group that used the version that was programmed in C. These results and the issues surrounding the study are described in this paper. C1 USA,RES INST,FT GORDON,GA 30905. RP OREY, M (reprint author), UNIV GEORGIA,ATHENS,GA 30602, USA. NR 9 TC 1 Z9 1 U1 0 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0360-1315 J9 COMPUT EDUC JI Comput. Educ. PD MAY PY 1994 VL 22 IS 4 BP 301 EP 313 DI 10.1016/0360-1315(94)90052-3 PG 13 WC Computer Science, Interdisciplinary Applications; Education & Educational Research SC Computer Science; Education & Educational Research GA NX875 UT WOS:A1994NX87500003 ER PT J AU GRZYBOWSKI, JA TAZIK, DJ SCHNELL, GD AF GRZYBOWSKI, JA TAZIK, DJ SCHNELL, GD TI REGIONAL-ANALYSIS OF BLACK-CAPPED VIREO BREEDING HABITATS SO CONDOR LA English DT Article DE BLACK-CAPPED VIREO; VIREO-ATRICAPILLUS; OKLAHOMA; TEXAS; HABITAT; HABITAT SELECTION; ENDANGERED SPECIES ID AVIAN COMMUNITY STRUCTURE; INTERSPECIFIC COMPETITION; GEOGRAPHIC-VARIATION; AMERICAN REDSTARTS; BIRD COMMUNITIES; FOREST; SELECTION; NICHE; WARBLERS; GRADIENT AB Structural vegetation components of Black-capped Vireo (Vireo atricapillus) breeding habitats and unoccupied scrubland areas were analyzed at 13 sites from three regions: the Lampasas Cut Plains in central Texas; the Wichita Mountains and adjacent areas in western Oklahoma; and the Edwards Plateau (Kerr County) in central Texas. We evaluated 61 vegetation variables from individual vireo territories and equivalent scrubland plots unoccupied by vireos. Principal components indicated strong vegetation trends for all plots involving the abundance of junipers (from high to low) and openness (from low to high) extending from the Lampasas Cut Plains to the Wichita Mountains and then to the Edwards Plateau. In all regions, vireo territories had relatively high densities of deciduous vegetation (primarily oaks) close to the ground (i.e., up to 1-2 m, and in one region 3 m). In addition, vireo territories occurred where variation in relative density measures of woody vegetation was highest. However, even with the vireo's limited geographic range, differences were found among regions in the vegetational characteristics of areas defended by territorial males. Vireos avoided higher juniper densities on the Lampasas Cut Plains and more open areas on the Edwards Plateau. On the Edwards Plateau, with generally less dense vegetation and the lowest density of junipers, the older (ASY; after-second-year) males selected territories with higher juniper densities at lower height intervals than found on nonvireo plots. Territories of second-year males (SY) and older males (ASY) differed in vegetation characteristics. On the Edwards Plateau, SY males occupied territories with vegetation structurally more like nonvireo plots than like territories of ASY males. In the Wichita Mountains, where a remnant vireo population occurs, territories of SY males were similar to those of ASY males. In both regions, however, SY males were found in more open habitats. Competition with other foliage-gleaning species may have played a role in restricting the Black-capped Vireo to early successional stages of scrubland habitats, where they also may effectively avoid several species of nest predators. Periodic habitat disturbance has beneficial effects for vireos and can be used in management of this endangered species. Attempts should be made to maintain 35 to 55% dispersed scrub cover (primarily deciduous) in spatially heterogeneous configurations. Sometimes inherent site characteristics (e.g., poor soils) may naturally promote the degree of vegetational heterogeneity requisite for Black-capped Vireos. Managers should employ techniques that encourage thick regrowth of deciduous woody vegetation. Typically, juniper cover should be kept well below 10%, which may be possible only through habitat manipulation. However, in areas where amounts of deciduous vegetation are marginal (e.g., Edwards Plateau region and to the southwest), junipers may contribute important cover. Thus, site and regional characteristics need consideration when making decisions about juniper control. C1 USA,CONSTRUCT ENGN RES LABS,DIV NAT RESOURCES,CHAMPAIGN,IL 61826. UNIV OKLAHOMA,OKLAHOMA BIOL SURVEY,NORMAN,OK 73019. UNIV OKLAHOMA,DEPT ZOOL,NORMAN,OK 73019. RP GRZYBOWSKI, JA (reprint author), UNIV CENT OKLAHOMA,DEPT BIOL,EDMOND,OK 73034, USA. NR 72 TC 33 Z9 36 U1 0 U2 7 PU COOPER ORNITHOLOGICAL SOC PI LAWRENCE PA ORNITHOLOGICAL SOC NORTH AMER PO BOX 1897, LAWRENCE, KS 66044-8897 SN 0010-5422 J9 CONDOR JI Condor PD MAY PY 1994 VL 96 IS 2 BP 512 EP 544 DI 10.2307/1369333 PG 33 WC Ornithology SC Zoology GA NN823 UT WOS:A1994NN82300021 ER PT J AU MARINO, MT PEGGINS, JO BROWN, LD URQUHART, MR BREWER, TG AF MARINO, MT PEGGINS, JO BROWN, LD URQUHART, MR BREWER, TG TI PHARMACOKINETICS AND KINETIC-DYNAMIC MODELING OF AN 8-AMINOQUINOLINE CANDIDATE ANTICYANIDE AND ANTIMALARIAL DRUG (WR242511) SO DRUG METABOLISM AND DISPOSITION LA English DT Article ID PHARMACODYNAMICS AB Malaria is a major cause of health problems in a large portion of the world. The 8-aminoquinoline compound, primaquine, is one of the only compounds useful for relapses of Plasmodium vivax and Plasmodium ovale malaria. Primaquine has several toxicities that include methemoglobinemia and hemolytic anemia. The induction of methemoglobinemia is a treatment for cyanide poisoning. We studied the pharmacokinetics and pharmacodynamics (percentage methemoglobin) for WR242511, an 8-aminoquinoline primaquine replacement and potential anticyanide compound. The drug's pharmacokinetics and pharmacodynamics are described for oral and intravenous dosing, and two kinetic-pharmacodynamic models are shown to describe the single dose data. A significant lag occurs between the onset of appearance of drug in the plasma and the onset of methemoglobinemia. Peak drug concentrations occurred within 4 hr for oral dosing, and peak effect (percentage methemoglobin) did not occur for 72-96 hrs for both the oral and intravenous routes. Elimination half-life for the drug was 30 +/- 14 hr. Two kinetic-dynamic models, one with an effect compartment relating drug concentration to effect and one with metabolite causing a first-order conversion of hemoglobin to methemoglobin, are compared as to their ability to predict multiple dose pharmacokinetics and pharmacodynamics. Both models were useful in predicting drug concentrations and methemoglobin levels for multiple-dose experiments. RP MARINO, MT (reprint author), WALTER REED ARMY MED CTR,DEPT PHARMACOL,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307, USA. NR 13 TC 2 Z9 2 U1 0 U2 1 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0090-9556 J9 DRUG METAB DISPOS JI Drug Metab. Dispos. PD MAY-JUN PY 1994 VL 22 IS 3 BP 358 EP 366 PG 9 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA NL978 UT WOS:A1994NL97800004 PM 8070311 ER PT J AU ABRAHAM, MH DU, CM OSEIOWUSU, JP AF ABRAHAM, MH DU, CM OSEIOWUSU, JP TI ON THE PREDICTION OF POLYMER PROBE CHI-VALUES AND OMEGA-VALUES FROM INVERSE GAS-CHROMATOGRAPHIC DATA SO EUROPEAN POLYMER JOURNAL LA English DT Article ID LIQUID-CHROMATOGRAPHY; HYDROCARBON POLYMERS; SOLVENT INTERACTIONS; STATIONARY PHASES; MOLECULAR-WEIGHT AB The solvation equation Log V(G) = c + rR2 + spi2H + aalpha2H + bbeta2H + 1 log L16 has been applied to the solubility of 24 probes on poly(butadiene) at 353, 363 and 373 K using V(G) values obtained by Romdhane and Danner by inverse gas-chromatography. In the above equation the explanatory variables are solute probe parameters as follows: R2 is an excess molar refraction, pi2H is the probe dipolarity/polarizability, alpha2H and beta2H are the probe hydrogen-bond acidity and basicity, and L16 is the probe ps-liquid partition coefficient on hexadecane at 298 K. It is shown that log V(G) can be predicted to +/-0.04 log units, using this equation, and that from the predicted log V(G) values, the weight fraction activity coefficient, OMEGA(infinity), can be predicted to around +/-0.04 log units, and the Flory-Huggins polymer-probe X coefficient to within +/-0.10 units. The same general equation has also been applied to literature data on the solubility of 50 probes on poly(trifluoropropyl)methyl siloxane at 298K, with similar results. C1 ICI PAINTS, RES DEPT, SLOUGH SL2 5DS, BERKS, ENGLAND. USA, CTR CHEM RES DEV & STANDARDIZAT, ABERDEEN PROVING GROUND, MD 21010 USA. RP UNIV LONDON UNIV COLL, DEPT CHEM, 20 GORDON ST, LONDON WC1H 0AJ, ENGLAND. NR 22 TC 4 Z9 4 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0014-3057 EI 1873-1945 J9 EUR POLYM J JI Eur. Polym. J. PD MAY PY 1994 VL 30 IS 5 BP 635 EP 639 DI 10.1016/0014-3057(94)90073-6 PG 5 WC Polymer Science SC Polymer Science GA NJ824 UT WOS:A1994NJ82400013 ER PT J AU SIM, BKL CARTER, JM DEAL, CD HOLLAND, C HAYNES, JD GROSS, M AF SIM, BKL CARTER, JM DEAL, CD HOLLAND, C HAYNES, JD GROSS, M TI PLASMODIUM-FALCIPARUM - FURTHER CHARACTERIZATION OF A FUNCTIONALLY ACTIVE-REGION OF THE MEROZOITE INVASION LIGAND EBA-175 SO EXPERIMENTAL PARASITOLOGY LA English DT Article DE MALARIA; PROTOZOAN ID ERYTHROCYTE BINDING ANTIGEN; PEPTIDE-SYNTHESIS; ESCHERICHIA-COLI; ANTIBODIES; IDENTIFICATION; EPITOPES; PROTEINS; SURFACE; ACID AB A 42 amino acid peptide, Pf EBA-175 (1062-1103), also called EBA-peptide 4 of the 175-kDa Plasmodium falciparum sialic acid binding protein, a putative merozoite invasion ligand, has been shown to be a target of parasite growth inhibitory antibodies. We expressed and purified a recombinant protein, NS1-Pf EBA-175 (946-1133) which included the 42 amino acid peptide, and compared antibodies induced by immunization with the protein to antibodies raised against the 42 amino acid peptide. Sera from rabbits immunized with the recombinant protein and the synthetic peptide immunoprecipitated authentic EBA-175, and had comparable ELISA titers against peptide Pf EBA-175 (1062-1103). However, IFAT titers against infected erythrocytes and growth inhibitory activity were substantially higher in sera from animals immunized with the 42 amino acid synthetic peptide. Epitope mapping of the 42 amino acid peptide identified a 19 amino acid peptide, Pf EBA-175 (1069-1087), which blocked the ability of antibodies against the 42 amino acid peptide to (1) immunoprecipitate EBA-175, (2) bind to the 42 amino acid peptide in an ELISA, and (3) recognize infected parasites in an IFAT. Sera from rabbits immunized with the 19 amino acid peptide conjugated to KLH had excellent parasite growth inhibitory activity (at 1:5 serum dilution, 49.9 +/- 7.4%, mean +/- SD of three separate assays), but the activity was lower in each of the three assays than that of sera from rabbits immunized with the 42 amino acid peptide (67.8 +/- 24.8%). These data indicate that the activity of antibodies raised against the linear 42 amino acid peptide, Pf EBA-175 (1062-1103) are primarily, if not exclusively, directed against 19 of the 42 amino acids, and identify this region of Pf EBA 175 as a target for vaccine development. (C) 1994 Academic Press, Inc. C1 SMITHKLINE BEECHAM PHARMACEUT,KING OF PRUSSIA,PA 19406. RP SIM, BKL (reprint author), WALTER REED ARMY MED CTR,DEPT IMMUNOL,WASHINGTON,DC 20307, USA. RI Carter, John Mark/K-2485-2015 OI Carter, John Mark/0000-0001-8251-4168 NR 22 TC 32 Z9 33 U1 1 U2 1 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0014-4894 J9 EXP PARASITOL JI Exp. Parasitol. PD MAY PY 1994 VL 78 IS 3 BP 259 EP 268 DI 10.1006/expr.1994.1027 PG 10 WC Parasitology SC Parasitology GA NK870 UT WOS:A1994NK87000002 PM 7512929 ER PT J AU KIPP, JW AF KIPP, JW TI THE ZHIRINOVSKY THREAT SO FOREIGN AFFAIRS LA English DT Article C1 UNIV KANSAS,LAWRENCE,KS 66045. RP KIPP, JW (reprint author), FOREIGN MIL STUDY OFF,FT LEAVENWORTH,KS, USA. NR 3 TC 5 Z9 5 U1 0 U2 0 PU COUNC FOREIGN RELAT INC PI NEW YORK PA 58 E 68TH ST, NEW YORK, NY 10021 SN 0015-7120 J9 FOREIGN AFF JI Foreign Aff. PD MAY-JUN PY 1994 VL 73 IS 3 BP 72 EP 86 DI 10.2307/20046659 PG 15 WC International Relations SC International Relations GA NH784 UT WOS:A1994NH78400009 ER PT J AU ANDERSON, DR GENNINGS, C CARTER, WH HARRIS, LW LENNOX, WJ BOWERSOX, SL SOLANA, RP AF ANDERSON, DR GENNINGS, C CARTER, WH HARRIS, LW LENNOX, WJ BOWERSOX, SL SOLANA, RP TI EFFICACY COMPARISON OF SCOPOLAMINE AND DIAZEPAM AGAINST SOMAN-INDUCED DEBILITATION IN GUINEA-PIGS SO FUNDAMENTAL AND APPLIED TOXICOLOGY LA English DT Article ID NERVE AGENTS; PROTECTION; PATHOLOGY; ATROPINE; PRETREATMENT; ANIMALS; THERAPY AB The efficacy of diazepam (DZ) and scopolamine (SCP), in combination with atropine (ATR) + oxime therapy, against soman-induced seizure/convulsive activity and associated brain damage has been demonstrated, but the efficacy of each against the incapacitating effects of soman has not been addressed. Thus, the therapeutic efficacies of SCP (5 doses; 0-0.86 mg/kg) and DZ (5 doses; 0-5 mg/kg), when each was used in conjunction with ATR (3 doses; 0.5-8 mg/kg) + 2-PAM (25 mg/kg) therapy, were compared in groups of pyridostigmine pretreated guinea pigs exposed to 1.6, 2.0, 2.5, or 3.2 LD50s of soman. Response surface methodology was employed to describe the relationship between soman-induced incapacitation and the ATR/DZ or ATR/SCP dosages. Incapacitation was measured by toxicity scores assigned by three graders to test animals at 60 min postsoman. Results show that as the dosage of SCP increased, the mean toxicity scores decreased. Also, within the indicated dose ranges used, the efficacy of SCP was not dependent on the presence of ATR. In contrast, ATR alone was found to be more effective than when combined with DZ at any dose, and indicates that DZ might be temporarily contributing to soman-induced incapacitation. These findings suggest that in guinea pigs, SCP could replace ATR or DZ, or both, as therapy against soman-induced incapacitation. (C) 1994 Society of Toxicology. C1 VIRGINIA COMMONWEALTH UNIV MED COLL VIRGINIA,RICHMOND,VA. RP ANDERSON, DR (reprint author), USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010, USA. NR 27 TC 17 Z9 17 U1 0 U2 3 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0272-0590 J9 FUND APPL TOXICOL JI Fundam. Appl. Toxicol. PD MAY PY 1994 VL 22 IS 4 BP 588 EP 593 DI 10.1006/faat.1994.1065 PG 6 WC Toxicology SC Toxicology GA NL761 UT WOS:A1994NL76100011 PM 8056205 ER PT J AU YAMAMOTO, K KADAKIA, SC AF YAMAMOTO, K KADAKIA, SC TI INCARCERATION OF A COLONOSCOPE IN AN INGUINAL-HERNIA SO GASTROINTESTINAL ENDOSCOPY LA English DT Letter RP YAMAMOTO, K (reprint author), BROOKE ARMY MED CTR,DEPT MED,GASTROENTEROL SERV,SAN ANTONIO,TX, USA. NR 7 TC 8 Z9 8 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0016-5107 J9 GASTROINTEST ENDOSC JI Gastrointest. Endosc. PD MAY-JUN PY 1994 VL 40 IS 3 BP 396 EP 397 PG 2 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA NR051 UT WOS:A1994NR05100048 PM 8056267 ER PT J AU MARSHALL, WJ AF MARSHALL, WJ TI COMPARATIVE HAZARD EVALUATION OF NEAR-INFRARED DIODE-LASERS SO HEALTH PHYSICS LA English DT Article DE RADIATION, NONIONIZING; LASERS; SAFETY STANDARDS; MAXIMUM PERMISSIBLE EXPOSURES AB Hazard evaluation methods from various laser protection standards differ when applied to extended-source, near-infrared lasers. By way of example, various hazard analyses are applied to laser training systems, which incorporate diode lasers, specifically those that assist in training military or law enforcement personnel in the proper use of weapons by simulating actual firing by the substitution of a beam of near-infrared energy for bullets. A correct hazard evaluation of these lasers is necessary since simulators are designed to be directed toward personnel during normal use. The differences among laser standards are most apparent when determining the hazard class of a laser. Hazard classification is based on a comparison of the potential exposures with the maximum permissible exposures in the 1986 and 1993 versions of the American National Standard for the Safe Use of Lasers, Z136.1, and the accessible emission limits of the federal laser product performance standard. Necessary safety design features of a particular system depend on the hazard class. The ANSI Z136.1-1993 standard provides a simpler and more accurate hazard assessment of low-power, near-infrared, diode laser systems than the 1986 ANSI standard. Although a specific system is evaluated, the techniques described can be readily applied to other near-infrared lasers or laser training systems. RP MARSHALL, WJ (reprint author), USA, ENVIRONM HYG AGCY, DIV LASER MICROWAVE, ABERDEEN PROVING GROUND, MD 21010 USA. NR 11 TC 3 Z9 3 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0017-9078 EI 1538-5159 J9 HEALTH PHYS JI Health Phys. PD MAY PY 1994 VL 66 IS 5 BP 532 EP 539 DI 10.1097/00004032-199405000-00004 PG 8 WC Environmental Sciences; Public, Environmental & Occupational Health; Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical Imaging SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical Imaging GA NF707 UT WOS:A1994NF70700004 PM 8175359 ER PT J AU CARR, NJ BRATTHAUER, GL LICHY, JH TAUBENBERGER, JK MONIHAN, JM SOBIN, LH AF CARR, NJ BRATTHAUER, GL LICHY, JH TAUBENBERGER, JK MONIHAN, JM SOBIN, LH TI SQUAMOUS-CELL PAPILLOMAS OF THE ESOPHAGUS - A STUDY OF 23 LESIONS FOR HUMAN PAPILLOMAVIRUS BY IN-SITU HYBRIDIZATION AND THE POLYMERASE CHAIN-REACTION SO HUMAN PATHOLOGY LA English DT Article DE ESOPHAGUS; SQUAMOUS CELL PAPILLOMA; HUMAN PAPILLOMAVIRUS; IN SITU HYBRIDIZATION; POLYMERASE CHAIN REACTION ID INSITU HYBRIDIZATION; BLOT HYBRIDIZATION; PRECANCER LESIONS; DNA; CARCINOMA; CANCER; VIRUS; INFECTION; SPECIMENS; HPV C1 USA,INST PATHOL,DEPT CELLULAR PATHOL,WASHINGTON,DC 20306. RP CARR, NJ (reprint author), USA,INST PATHOL,DEPT HEPAT & GASTROINTESTINAL PATHOL,ROOM 3005,WASHINGTON,DC 20306, USA. NR 57 TC 28 Z9 29 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0046-8177 J9 HUM PATHOL JI Hum. Pathol. PD MAY PY 1994 VL 25 IS 5 BP 536 EP 540 DI 10.1016/0046-8177(94)90128-7 PG 5 WC Pathology SC Pathology GA NP557 UT WOS:A1994NP55700016 PM 8200650 ER PT J AU LIS, RJ ZHAO, JH ZHU, LD ILLAN, J MCAFEE, S BURKE, T WEINER, M BUCHWALD, WR JONES, KA AF LIS, RJ ZHAO, JH ZHU, LD ILLAN, J MCAFEE, S BURKE, T WEINER, M BUCHWALD, WR JONES, KA TI AN LPE GROWN INP BASED OPTOTHYRISTOR FOR POWER SWITCHING APPLICATIONS SO IEEE TRANSACTIONS ON ELECTRON DEVICES LA English DT Article ID GAAS AB This paper presents the results of a new InP based optothyristor for pulsed high power switching applications and compares them with a traditional InP photoconductive switch operating under similar conditions. The optothyristor utilized a semi-insulating InP wafer inserted between the two PN junctions in a conventional thyristor structure. We also determined the dynamic I-V characteristics and the di/dt turn-on parameter for this novel optothyristor. Using a 1.06 mum YAG laser to trigger the optothyristor, we have achieved a 1200 V (4.8 X 10(4) V/cm) hold-off voltage with a maximum current of 61 A. The current rise time for device turn-on was measured to be consistently under 12 ns, and a maximum di/dt of 1.4 x 10(10)) A/s was obtained. C1 USA,LABCOM,EPS DIRECTORATE,FT MONMOUTH,NJ 07703. RP LIS, RJ (reprint author), RUTGERS STATE UNIV,DEPT ELECT & COMP ENGN,HIGH VOLTAGE DESIGN GRP,TECH STAFF,PISCATAWAY,NJ 08855, USA. NR 13 TC 5 Z9 5 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9383 J9 IEEE T ELECTRON DEV JI IEEE Trans. Electron Devices PD MAY PY 1994 VL 41 IS 5 BP 809 EP 813 DI 10.1109/16.285035 PG 5 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA NN185 UT WOS:A1994NN18500028 ER PT J AU ZHAO, JH BURKE, T WEINER, M CHIN, A BALLINGALL, JM AF ZHAO, JH BURKE, T WEINER, M CHIN, A BALLINGALL, JM TI A NOVEL HIGH-POWER OPTOTHYRISTOR BASED ON ALGAAS/GAAS FOR PULSED POWER-SWITCHING APPLICATIONS SO IEEE TRANSACTIONS ON ELECTRON DEVICES LA English DT Article AB Double-side molecular beam epitaxial growth on a thick LEC-grown semi-insulating (SI) GaAs wafer has been used to demonstrate a novel high power optothyristor for pulsed power-switching applications. The optothyristor has a P+N-SI-PN+ thyristor-like structure with the capital P and N stand for the wider bandgap optical window material, AlGaAs, and the SI stands for a 650 mum SI-GaAs substrate. With the ''insertion'' of the SI-GaAs bulk material into the conventional P+NPN+ thyristor structure and the use of wider bandgap AlGaAs, the device has achieved a record high performance compared to the existing GaAs or AlGaAs/GaAs based epitaxial thyristors. The performance of the optothyristors under forward bias has been characterized, including 1) the low field dynamic current-voltage characteristics to show post-triggering carrier injections, 2) the switched-current waveforms with varying device blocking voltage and from which the turn-on speed di/dt, and 3) the dependence of the switched-current amplitude on the laser triggering position. C1 GE CO,ELECTR LAB,SYRACUSE,NY 13221. USA,RES LAB,EPS DIRECTORATE,FT MONMOUTH,NJ 07703. GE CO,III V MAT LAB,SYRACUSE,NY 13221. RP ZHAO, JH (reprint author), RUTGERS STATE UNIV,DEPT ELECT & COMP ENGN,PISCATAWAY,NJ 08855, USA. NR 14 TC 2 Z9 2 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9383 J9 IEEE T ELECTRON DEV JI IEEE Trans. Electron Devices PD MAY PY 1994 VL 41 IS 5 BP 819 EP 825 DI 10.1109/16.285037 PG 7 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA NN185 UT WOS:A1994NN18500030 ER PT J AU ESTEP, L AF ESTEP, L TI DIFFUSE ATTENUATION COEFFICIENT PROFILES SO IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING LA English DT Note AB Diffuse attenuation coefficient (k(d), k(u)) eigenanalysis, using field data, is performed. Data are partitioned into wavelength, province, season, and up/downwelling k. Resulting eigenvectors and scalar multiples allow a reconstruction of the original k profiles. Parameterizing the scalar multiples, using satellite derived surface k's, k depth profiles are computed. RP ESTEP, L (reprint author), USA CORPS ENGINEERS,WATERWAYS EXPT STN,COASTAL RES ENGN LAB,VICKSBURG,MS 39180, USA. NR 12 TC 0 Z9 0 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0196-2892 J9 IEEE T GEOSCI REMOTE JI IEEE Trans. Geosci. Remote Sensing PD MAY PY 1994 VL 32 IS 3 BP 702 EP 706 DI 10.1109/36.297988 PG 5 WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote Sensing; Imaging Science & Photographic Technology SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science & Photographic Technology GA NY447 UT WOS:A1994NY44700023 ER PT J AU SHARPE, RN CHOW, MY BRIGGS, S WINDINGLAND, L AF SHARPE, RN CHOW, MY BRIGGS, S WINDINGLAND, L TI A METHODOLOGY USING FUZZY-LOGIC TO OPTIMIZE FEEDFORWARD ARTIFICIAL NEURAL-NETWORK CONFIGURATIONS SO IEEE TRANSACTIONS ON SYSTEMS MAN AND CYBERNETICS LA English DT Article DE ARTIFICIAL NEURAL NETWORKS; FUZZY LOGIC; NETWORK CONFIGURATIONS; COST FUNCTIONS; SENSITIVITY; ROBUSTNESS; FAULT DETECTION ID CONTROL-SYSTEMS; BOUNDS AB After a problem has been formulated for solution by using artificial neural network technology, the next step is to determine the appropriate network configuration to be used in achieving a desired level of performance. Due to the real world environment and implementation constraints, different problems require different evaluation criteria such as: accuracy, training time, sensitivity, and the number of neurons used. Tradeoffs exist between these measures, and compromises are needed in order to achieve an acceptable network design. This paper will present a method using fuzzy logic techniques to adapt the current network configuration to one which is dose to (if not at) the optimal configuration. The fuzzy logic provides a method of systematically changing the network configuration while simultaneously considering all of the evaluation criteria. The optimal configuration is determined by a cost function based on the evaluation criteria. The proposed methodology will be applied to an elementary classifier network as an illustration. The procedure will then be used to automatically configure a network used to detect incipient faults in an induction motor as a real world application. C1 N CAROLINA STATE UNIV,DEPT ELECT ENGN,RALEIGH,NC 27695. N CAROLINA STATE UNIV,DEPT MECH & AEROSP ENGN,RALEIGH,NC 27695. N CAROLINA STATE UNIV,DEPT ELECT & COMP ENGN,RALEIGH,NC 27695. USA,CORPS ENGINEERS,CONSTRUCT ENGN RES LAB,CHAMPAIGN,IL 61826. NR 34 TC 20 Z9 20 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9472 J9 IEEE T SYST MAN CYB JI IEEE Trans. Syst. Man Cybern. PD MAY PY 1994 VL 24 IS 5 BP 760 EP 768 DI 10.1109/21.293489 PG 9 WC Computer Science, Cybernetics; Engineering, Electrical & Electronic SC Computer Science; Engineering GA NU554 UT WOS:A1994NU55400005 ER PT J AU STEWART, JT YONG, YK AF STEWART, JT YONG, YK TI EXACT ANALYSIS OF THE PROPAGATION OF ACOUSTIC-WAVES IN MULTILAYERED ANISOTROPIC PIEZOELECTRIC PLATES SO IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL LA English DT Article AB Exact analysis of the propagation of acoustic waves in multilayered piezoelectric plates is performed using the transfer matrix method. A general technique for analyzing layered piezoelectric resonators under thickness and lateral field excitation is presented and is applied to the study of zinc oxide on silicon thin film resonators. Both one and two-dimensional analysis with general material anisotropy is performed, and a simplified method for incorporating thin conducting electrodes on the plate's free surfaces is presented. The general methodology described is summarized into efficient algorithms to aid in the implementation of the procedures and some computational aspects are discussed. Results are presented for cutoff behavior as well as general dispersion characteristics for two and three layered plates. C1 RUTGERS STATE UNIV,DEPT CIVIL & ENVIRONM ENGN,PISCATAWAY,NJ 08855. RP STEWART, JT (reprint author), USA,AMSRC EP,FT MONMOUTH,NJ 07703, USA. NR 13 TC 58 Z9 60 U1 1 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0885-3010 J9 IEEE T ULTRASON FERR JI IEEE Trans. Ultrason. Ferroelectr. Freq. Control PD MAY PY 1994 VL 41 IS 3 BP 375 EP 390 DI 10.1109/58.285473 PG 16 WC Acoustics; Engineering, Electrical & Electronic SC Acoustics; Engineering GA NM302 UT WOS:A1994NM30200011 ER PT J AU CHUKWUOCHA, RU HARTMAN, AB FEENEY, AJ AF CHUKWUOCHA, RU HARTMAN, AB FEENEY, AJ TI SEQUENCES OF 4 NEW MEMBERS OF THE V(H)7183 GENE FAMILY IN BALB/C MICE SO IMMUNOGENETICS LA English DT Note ID PRE-B-CELLS; VH-GENES; PREDOMINANCE; REPERTOIRE; ANTIBODIES; DIVERSITY; FETAL; MOUSE C1 Scripps Res Inst, DEPT IMMUNOL, LA JOLLA, CA 92037 USA. WALTER REED ARMY INST RES, DEPT ENTER INFECT, WASHINGTON, DC 20307 USA. FU NIAID NIH HHS [R01-AI29672] NR 11 TC 24 Z9 25 U1 0 U2 1 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0093-7711 J9 IMMUNOGENETICS JI Immunogenetics PD MAY PY 1994 VL 40 IS 1 BP 76 EP 78 DI 10.1007/BF00163968 PG 3 WC Genetics & Heredity; Immunology SC Genetics & Heredity; Immunology GA NN362 UT WOS:A1994NN36200011 PM 8206530 ER PT J AU GREEN, MS COHEN, D LERMAN, Y SJOGREN, M BINN, LN ZUR, S SLEPON, R ROBIN, G HOKE, C BANCROFT, W SAFARY, A DANON, Y WIENER, M AF GREEN, MS COHEN, D LERMAN, Y SJOGREN, M BINN, LN ZUR, S SLEPON, R ROBIN, G HOKE, C BANCROFT, W SAFARY, A DANON, Y WIENER, M TI A TRIAL OF THE REACTOGENICITY AND IMMUNOGENICITY OF AN INACTIVATED HEPATITIS-A VACCINE SO ISRAEL JOURNAL OF MEDICAL SCIENCES LA English DT Article; Proceedings Paper CT 2nd International Symposium on Recent Developments in Perinatal and Childhood Infections CY AUG 23-29, 1992 CL JERUSALEM, ISRAEL SP MINIST HLTH ISRAEL, SHAARE MED CTR, HEBREW UNIV HADASSAH MED SCH, ISRAEL ACAD SCI & HUMANITIES DE INFECTIOUS DISEASE; HEPATITIS A; VACCINE; IMMUNOGENICITY ID A VIRUS-VACCINE; VOLUNTEERS; EFFICACY; STRAINS; ORIGIN AB Purified, formaldehyde-inactivated and alum-adjuvanted hepatitis A virus (HAV) vaccines have recently become available for clinical trials. The vaccine is administered intramuscularly in a schedule of 0, 1, and 6 months. The aim of the study was to evaluate the reactogenicity and immunogenicity of an inactivated hepatitis A (HA) vaccine. Three groups of volunteers comprised the study population: 28 volunteers without antibody to HAV were given HA vaccine and, for comparison, 43 subjects received hepatitis B vaccine for possible adverse reactions to the HA vaccine; 12 other subjects received immunoglobulin alone. Each 1 ml dose of HA vaccine contained 720 enzyme units or about 100 ng of antigen. Anti-HAV was determined by means of a commercial assay (Abbott Laboratories: HAV-EIA), and by a more sensitive ELISA. No significant adverse reactions were reported. In the group that received HA vaccine, 4 weeks following the first dose all had detectable antibodies (greater than or equal to 20 mIU/ml) by the sensitive ELISA. By commercial HAV-EIA, at 20 weeks following the second dose 75.0% had detectable antibodies, and after the third vaccine all had detectable antibodies. This new inactivated HA vaccine is highly immunogenic and had no significant side effects. C1 ISAEL DEF FORCES,MED CORPS,MIL POST,ISRAEL. USA,MED RES INST INFECT DIS,FREDERICK,MD. SMITHKLINE BEECHAM BIOL,RIXENSART,BELGIUM. WALTER REED ARMY INST RES,WASHINGTON,DC. NR 16 TC 3 Z9 3 U1 0 U2 0 PU ISRAEL JOURNAL MED SCIENCES PI JERUSALEM PA 2 ETZEL ST, FRENCH HILL, JERUSALEM 97853, ISRAEL SN 0021-2180 J9 ISRAEL J MED SCI JI Isr. J. Med. Sci. PD MAY-JUN PY 1994 VL 30 IS 5-6 BP 485 EP 488 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA NX734 UT WOS:A1994NX73400040 PM 8034508 ER PT J AU BENEDIKT, RA JELINEK, JS KRANSDORF, MJ MOSER, RP BERREY, BH AF BENEDIKT, RA JELINEK, JS KRANSDORF, MJ MOSER, RP BERREY, BH TI MR-IMAGING OF SOFT-TISSUE MASSES - ROLE OF GADOPENTETATE DIMEGLUMINE SO JMRI-JOURNAL OF MAGNETIC RESONANCE IMAGING LA English DT Article DE ANGIOMA; CONTRAST ENHANCEMENT; GADOLINIUM; HISTIOCYTOMA; SOFT TISSUES, INFECTION; SOFT TISSUES; SOFT TISSUES, NEOPLASMS ID GADOLINIUM-DTPA ENHANCEMENT; BENIGN EXTRAAXIAL TUMORS; GD-DTPA; MUSCULOSKELETAL NEOPLASMS; CONTRAST ENHANCEMENT; METASTASES; DIAGNOSIS; LESIONS; BRAIN AB To assess the effectiveness of gadopentetate dimeglumine in the magnetic resonance (MR) imaging evaluation of soft-tissue masses without osseous involvement, 30 patients underwent MR imaging before and after administration of contrast material (0.1 mmol/kg). Of the 30 lesions, 22 were benign and eight were malignant; histologic confirmation was available in all lesions except one benign lesion. Overall, enhancement was detected in 26 (87%) of 30 lesions: 18 (82%) of the 22 benign lesions and eight (100%) of eight malignant lesions. Enhancement was characterized as homogeneous (two [11%] benign lesions, two [25%] malignant lesions). inhomogeneous (11 [61%] benign lesions. six [75%] malignant lesions), or peripheral (five [28%] benign lesions, no malignant lesions). Of the 19 lesions assessed for a change in enhancement over time, seven (37%) showed an increase and two (11%) showed a decrease in signal intensity. The authors conclude that benign and malignant soft-tissue lesions could not be differentiated solely on the basis of enhancement (pattern, degree, or time course). C1 WALTER REED ARMY INST RES,DEPT RADIOL,WASHINGTON,DC 20307. WALTER REED ARMY INST RES,DEPT ORTHOPED SURG,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,DEPT RADIOL & NUCL MED,BETHESDA,MD 20814. UNIFORMED SERV UNIV HLTH SCI,DEPT SURG,BETHESDA,MD 20814. WASHINGTON HOSP CTR,DEPT RADIOL,WASHINGTON,DC 20010. ARMED FORCES INST PATHOL,DEPT RADIOL PATHOL,WASHINGTON,DC 20306. PENN STATE UNIV,MILTON S HERSHEY MED CTR,DEPT RADIOL,HERSHEY,PA 17033. BROOKE ARMY MED CTR,DEPT RADIOL,FT SAM HOUSTON,TX 78234. ST MARYS HOSP,DEPT RADIOL,RICHMOND,VA 23226. NR 17 TC 22 Z9 22 U1 0 U2 0 PU SOC MAGNETIC RESONANCE IMAGING PI EASTON PA 1991 NORTHAMPTON ST, EASTON, PA 18042-3189 SN 1053-1807 J9 JMRI-J MAGN RESON IM JI JMRI-J. Magn. Reson. Imaging PD MAY-JUN PY 1994 VL 4 IS 3 BP 485 EP 490 DI 10.1002/jmri.1880040341 PG 6 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA NP292 UT WOS:A1994NP29200037 PM 8061453 ER PT J AU HEWITT, AD AF HEWITT, AD TI PREPARATION OF SPIKED SOILS BY VAPOR FORTIFICATION FOR VOLATILE ORGANIC-COMPOUNDS ANALYSIS SO JOURNAL OF AOAC INTERNATIONAL LA English DT Article ID WATER AB This paper describes a vapor fortification method for preparing quality assurance/quality control soils for volatile organic compound analysis. Treatment of soils with volatile organic compounds occurs in a closed container in a manner somewhat analogous to the way the vadose zone often becomes contaminated. One advantage of this method for preparing soils for quality assurance/quality control purposes is that the efficiency of various extraction methods can be reliably compared. Furthermore, by substantially reducing the error due to sample inhomogeneity, the error associated with the determinative step can also be properly evaluated. RP HEWITT, AD (reprint author), USA,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 15 TC 5 Z9 5 U1 0 U2 1 PU AOAC INTERNATIONAL PI GAITHERSBURG PA 481 NORTH FREDRICK AVE, STE 500, GAITHERSBURG, MD 20877-2504 SN 1060-3271 J9 J AOAC INT JI J. AOAC Int. PD MAY-JUN PY 1994 VL 77 IS 3 BP 735 EP 737 PG 3 WC Chemistry, Analytical; Food Science & Technology SC Chemistry; Food Science & Technology GA NP559 UT WOS:A1994NP55900033 ER PT J AU CLARKE, FW AF CLARKE, FW TI NONDESTRUCTIVE DETERMINATION OF FREE-ELECTRON CONCENTRATION AND MOBILITY IN HG(1-X)CD(X)TE, N-TYPE INSB, AND N-TYPE GAAS SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID HG1-XCDXTE AB A method for nondestructive determination of free-electron concentration and mobility using Faraday rotation and absorption at mid-infrared wavelengths is presented. Faraday rotation measurements were made at four CO2 laser wavelengths between 9 and 11 mum. The component due to free electrons was extracted using its wavelength dependence. Concentration N was determined for N > 10(14) cm-3 from calibration plots exploiting Faraday rotation's linear dependence on free electron concentration. Electron rotation was combined with absorption due to electrons to determine their mobility. These mobilities agreed reasonably well with Hall test mobilities in materials where electron absorption could be determined separately from hole absorption. In materials where hole and electron absorption cannot be determined separately, a reference mobility was calculated using an electron absorption cross section. Samples tested were Hg1-xCdxTe for 0.20 less-than-or-equal-to x less-than-or-equal-to 0.30, n-type and intrinsic InSb, and n-type GaAs at room temperature. RP CLARKE, FW (reprint author), USA,MISSILE COMMAND,WEAP SCI DIRECTORATE,AMSMI RD WS CM,CTR RES DEV & ENGN,REDSTONE ARSENAL,AL 35898, USA. NR 31 TC 2 Z9 2 U1 0 U2 1 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD MAY 1 PY 1994 VL 75 IS 9 BP 4319 EP 4326 DI 10.1063/1.355974 PG 8 WC Physics, Applied SC Physics GA NJ734 UT WOS:A1994NJ73400003 ER PT J AU LEE, CY TIDROW, MZ CHOI, KK CHANG, WH EASTMAN, LF TOWNER, FJ AHEARN, JS AF LEE, CY TIDROW, MZ CHOI, KK CHANG, WH EASTMAN, LF TOWNER, FJ AHEARN, JS TI LONG-WAVELENGTH LAMBDA(C)=18-MU-M INFRARED HOT-ELECTRON TRANSISTOR SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID PHOTODETECTORS AB A long-wavelength lambda(c) = 18 mum infrared hot-electron transistor (IHET) with low dark current is demonstrated. In order to achieve long-wavelength absorption, a low barrier height is required, which in tum results in a large dark current. Therefore, operation of a normal long-wavelength quantum-well infrared photodetector (QWIP) structure is limited to very low temperatures and biases due to the thermally activated dark current. In the IHET, a high-energy pass filter placed after 30 periods of GaAs/AlGaAs quantum wells blocks the temperature-activated dark current while allowing high-energy photoexcited electrons to pass and be collected as photocurrent. A comparison of the dark current to the 300 K background photocurrent shows that the QWIP structure without the high-energy pass filter demonstrates background-limited infrared photodetection (BLIP) only at T less-than-or-equal-to 35 K. Furthermore, in order to avoid saturating a typical readout circuit, detector operation of the QWIP is restricted to biases less than 0.08 V at 35 K. In contrast, the filtered dark current in the IHET is reduced by two to four orders of magnitude such that BLIP performance can be achieved for temperatures up to T = 55 K without saturating the readout circuit. Because of the preferential current filtering effect, the noise equivalent temperature difference of the IHET can be improved by a factor of 100 at T = 55 K. The dark-current-limited detectivity was found to be D* = 1 X 10(10) cm Hz1/2/W at lambda(p) = 15 mum, V(e) = -0.2 V, and T = 55 K. C1 MARTIN MARIETTA CORP LABS,BALTIMORE,MD 21227. RP LEE, CY (reprint author), USA,RES LAB,EPSD,FT MONMOUTH,NJ 07703, USA. RI Choi, Kwong-Kit/K-9205-2013 NR 7 TC 11 Z9 11 U1 0 U2 1 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD MAY 1 PY 1994 VL 75 IS 9 BP 4731 EP 4736 DI 10.1063/1.355927 PG 6 WC Physics, Applied SC Physics GA NJ734 UT WOS:A1994NJ73400064 ER PT J AU SHIH, ML MCMONAGLE, JD DOLZINE, TW GRESHAM, VC AF SHIH, ML MCMONAGLE, JD DOLZINE, TW GRESHAM, VC TI METABOLITE PHARMACOKINETICS OF SOMAN, SARIN AND GF IN RATS AND BIOLOGICAL MONITORING OF EXPOSURE TO TOXIC ORGANOPHOSPHORUS AGENTS SO JOURNAL OF APPLIED TOXICOLOGY LA English DT Article DE SOMAN; SARIN; GF; ALKYLMETHYLPHOSPHONIC ACID; METABOLITE; PHARMACOKINETICS; ELIMINATION ID MICE AB This study reports on the pharmacokinetics of the elimination of the metabolites of three toxic organophosphorus compounds (soman, sarin and GF). Urine, blood and lung tissue were collected from Fats dosed subcutaneously at 75 mu g kg(-1). Urinary excretion of the metabolite was the major elimination route for these three compounds. The major differences among them were primarily the extent and rate of excretion. The hydrolyzed form, alkylmethylphosphonic acid, was the single major metabolite formed and excreted in urine by a non-saturable mechanism. Nearly total recoveries of the given doses for sarin and GF in metabolite form were obtained from the urine. The terminal elimination half-lives in urine were 3.7 +/- 0.1 and 9.9 +/- 0.8 h for sarin and GF, respectively. Soman metabolite showed a biphasic elimination curve with terminal half-lives of 18.5 +/- 2.7 and 3.6 +/- 2.2 h. Soman was excreted at a slower rate with a recovery of only 62%. Lung was the major organ of accumulation for soman. In blood the toxic agents were concentrated more in red blood cells than in plasma, The acid metabolites can serve as a better chemical marker for monitoring organophosphorns exposure in humans via their higher concentration and longer half-life in urine than the parent compounds. RP SHIH, ML (reprint author), USA,MED RES INST CHEM DEF,SGRD UV VA,ABERDEEN PROVING GROUND,MD 21010, USA. NR 11 TC 39 Z9 39 U1 0 U2 4 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0260-437X J9 J APPL TOXICOL JI J. Appl. Toxicol. PD MAY-JUN PY 1994 VL 14 IS 3 BP 195 EP 199 DI 10.1002/jat.2550140309 PG 5 WC Toxicology SC Toxicology GA NQ006 UT WOS:A1994NQ00600009 PM 8083481 ER PT J AU BANTLE, JA BURTON, DT DAWSON, DA DUMONT, JN FINCH, RA FORT, DJ LINDER, G RAYBURN, JR BUCHWALTER, D MAURICE, MA TURLEY, SD AF BANTLE, JA BURTON, DT DAWSON, DA DUMONT, JN FINCH, RA FORT, DJ LINDER, G RAYBURN, JR BUCHWALTER, D MAURICE, MA TURLEY, SD TI INITIAL INTERLABORATORY VALIDATION-STUDY OF FETAX - PHASE-I TESTING SO JOURNAL OF APPLIED TOXICOLOGY LA English DT Article DE FETAX; XENOPUS; TERATOGEN; HYDROXYUREA; ISONIAZID; 6-AMINONICOTINAMIDE; INTERLABORATORY VALIDATION ID EMBRYO TERATOGENESIS ASSAY; METABOLIC-ACTIVATION SYSTEM; DECLINING AMPHIBIAN POPULATIONS; INDUCED DEVELOPMENTAL TOXICITY; XENOPUS FETAX; IDENTIFICATION; EFFICACY AB An interlaboratory validation study was undertaken to evaluate the repeatability and reliability of the Frog Embryo Teratogenesis Assay-Xenopus (FETAX), which is a whole embryo developmental toxicity screening assay. A three-phase experimental program with seven participants was carried out. Phase I was a training and protocol evaluation phase where the identity of the three test materials was known. Hydroxyurea, isoniazid and 6-aminonicotinamide were tested in Phase I. Because the chemicals has been tested previously in FETAX, the same concentrations needed to establish the 96-h median lethal concentration (LC(50)) and the concentration inducing malformations in 50% of the surviving embryos (EC(50)) were used by all laboratories. The results of Phase I are presented in this report, and FETAX has proved to be as repeatable and reliable as many other bioassays. Some excess variation was observed in individual laboratories. Some of this variation may have been due to training difficulties. One change in protocol design necessitated by this study was the use of 6-aminonicotinamide as a reference toxicant. While 6-aminonicotinamide provided excellent concentration-response data in most laboratories, the protocol was written too strictly based on historical FETAX data. Phases II and m are currently in progress. C1 UNIV MARYLAND,WYE RES & EDUC CTR,QUEENSTOWN,MD 21658. UNIV TENNESSEE,COLL VET MED,KNOXVILLE,TN 37901. OAK RIDGE NATL LAB,DEPT QUAL,OAK RIDGE,TN 37830. USA,BIOMED RES & DEV LAB,FREDERICK,MD 21702. STOVER BIOMETR LABS INC,STILLWATER,OK 74076. MANTECH ENVIRONM TECHNOL INC,ENVIRONM RES LAB,CORVALLIS,OR 97333. RP BANTLE, JA (reprint author), OKLAHOMA STATE UNIV,DEPT ZOOL,STILLWATER,OK 74078, USA. NR 39 TC 25 Z9 28 U1 0 U2 0 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0260-437X J9 J APPL TOXICOL JI J. Appl. Toxicol. PD MAY-JUN PY 1994 VL 14 IS 3 BP 213 EP 223 DI 10.1002/jat.2550140312 PG 11 WC Toxicology SC Toxicology GA NQ006 UT WOS:A1994NQ00600012 PM 8083483 ER PT J AU BRATOEVA, MP WOLF, MK MARKS, JK CANTEY, JR AF BRATOEVA, MP WOLF, MK MARKS, JK CANTEY, JR TI A CASE OF DIARRHEA, BACTEREMIA, AND FEVER CAUSED BY A NOVEL STRAIN OF ESCHERICHIA-COLI SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Note ID TISSUE-CULTURE CELLS; DNA PROBE; EAE GENE; ADHERENCE FACTOR; HEP-2 CELLS; INVASION; CLONING; O157-H7 AB A nonenteropathogenic strain of Escherichia coli from a patient with diarrhea and bacteremia possessed the attaching-effacing ene gene, was invasive in the gentamicin invasion assay, and expressed two types of pili and K1 antigen. This unique combination places the strain in a new category of attaching-effacing E. coli. C1 MED UNIV S CAROLINA,DEPT MED,DIV INFECT DIS,CHARLESTON,SC 29425. RALPH H JOHNSON VET ADM MED CTR,CHARLESTON,SC. WALTER REED ARMY INST RES,WASHINGTON,DC. NR 20 TC 2 Z9 2 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD MAY PY 1994 VL 32 IS 5 BP 1383 EP 1386 PG 4 WC Microbiology SC Microbiology GA NG217 UT WOS:A1994NG21700050 PM 7914208 ER PT J AU TEEL, LD FINELLI, MR JOHNSON, SC AF TEEL, LD FINELLI, MR JOHNSON, SC TI ISOLATION OF MYCOPLASMA SPECIES FROM BRONCHOALVEOLAR LAVAGES OF PATIENTS POSITIVE AND NEGATIVE FOR HUMAN-IMMUNODEFICIENCY-VIRUS SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Note ID INFECTIOUS AGENT; AIDS; INCOGNITUS AB The rates of isolation of Mycoplasma species from bronchoalveolar lavages of human immunodeficiency virus (HIV)-infected patients and HIV-negative patients were compared. Mycoplasma species were more frequently isolated from HIV-positive patients. In most cases, a known pulmonary pathogen was also identified. All samples tested negative for Mycoplasma fermentans by PCR. C1 WALTER REED ARMY MED CTR,HENRY M JACKSON FDN ADV MIL MED,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT CLIN PATHOL,MICROBIOL LAB,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT MED,INFECT DIS SERV,WASHINGTON,DC 20307. NR 23 TC 8 Z9 9 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD MAY PY 1994 VL 32 IS 5 BP 1387 EP 1389 PG 3 WC Microbiology SC Microbiology GA NG217 UT WOS:A1994NG21700051 PM 8051276 ER PT J AU GULLIANI, D WILUSZ, E GALEZEWSKI, A AF GULLIANI, D WILUSZ, E GALEZEWSKI, A TI FLAME-RETARDANT ELASTOMERS FOR CHEMICAL PROTECTIVE GLOVES SO JOURNAL OF FIRE SCIENCES LA English DT Article RP GULLIANI, D (reprint author), USA,NATICK RES DEV & ENGN CTR,NATICK,MA 01760, USA. NR 4 TC 0 Z9 0 U1 0 U2 1 PU TECHNOMIC PUBL CO INC PI LANCASTER PA 851 NEW HOLLAND AVE, BOX 3535, LANCASTER, PA 17604 SN 0734-9041 J9 J FIRE SCI JI J. Fire Sci. PD MAY-JUN PY 1994 VL 12 IS 3 BP 246 EP 256 DI 10.1177/073490419401200302 PG 11 WC Engineering, Multidisciplinary; Materials Science, Multidisciplinary SC Engineering; Materials Science GA NL935 UT WOS:A1994NL93500002 ER PT J AU RAHARJO, S DEXTER, DR WORFEL, RC SOFOS, JN SOLOMON, MB SHULTS, GW SCHMIDT, GR AF RAHARJO, S DEXTER, DR WORFEL, RC SOFOS, JN SOLOMON, MB SHULTS, GW SCHMIDT, GR TI RESTRUCTURING VEAL STEAKS WITH SALT/PHOSPHATE AND SODIUM ALGINATE CALCIUM LACTATE SO JOURNAL OF FOOD SCIENCE LA English DT Article DE RESTRUCTURED STEAKS; VEAL; NACL; PHOSPHATE; NA-ALGINATE; CA-LACTATE ID STRUCTURED BEEF STEAKS; OXIDATIVE STABILITY; OLEORESIN ROSEMARY; COLOR STABILITY; TRIPOLYPHOSPHATE; CHLORIDE; ROASTS; TURKEY; BINDER; SALT AB Quality characteristics of restructured steaks formulated with veal trimmings or veal leg meat and Na-alginate/Ca-lactate or salt (NaCl)/phosphate were evaluated. Trimmings restructured with salt/phosphate had higher (P<0.05) bind scores (measured instrumentally and by sensory) than veal trimmings restructured with Na-alginate/Ca-lactate. Salt/phosphate (0.3-0.5%) reduced (P<0.05) purge and increased binding force and sensory score of bind in restructured veal trimmings and leg meat compared to control and Na-alginate/Ca-lactate treatments. The use of Na-alginate/Ca-lactate as a binder for veal leg meat increased (P<0.05) binding force and sensory score of bind and decreased cook loss when used at 0.4%. C1 COLORADO STATE UNIV,DEPT ANIM SCI,FT COLLINS,CO 80523. USDA ARS,MEAT SCI RES LAB,BELTSVILLE,MD 20705. USA,NATICK RES,CTR DEV & ENGN,FOOD ENGN DIRECTORATE,PROD DEV & ENGN BRANCH,NATICK,MA 01760. NR 24 TC 9 Z9 10 U1 1 U2 5 PU INST FOOD TECHNOLOGISTS PI CHICAGO PA SUITE 300 221 N LASALLE ST, CHICAGO, IL 60601-1291 SN 0022-1147 J9 J FOOD SCI JI J. Food Sci. PD MAY-JUN PY 1994 VL 59 IS 3 BP 471 EP 473 DI 10.1111/j.1365-2621.1994.tb05540.x PG 3 WC Food Science & Technology SC Food Science & Technology GA NW348 UT WOS:A1994NW34800004 ER PT J AU BARRETT, AH ROSENBERG, S ROSS, EW AF BARRETT, AH ROSENBERG, S ROSS, EW TI FRACTURE INTENSITY DISTRIBUTIONS DURING COMPRESSION OF PUFFED CORN MEAL EXTRUDATES - METHOD FOR QUANTIFYING FRACTURABILITY SO JOURNAL OF FOOD SCIENCE LA English DT Article DE CORN MEAL; EXTRUDATES; FRACTURABILITY; COMPRESSION ID EXTRUSION; MOISTURE; FLOUR AB The distribution of fracture intensities occurring during compression of puffed corn meal extrudates was described using an exponential function, and parameters from that analysis were used as fracturability indices. Since ''jagged'' or oscillating stress-strain functions are typical for porous and brittle materials, fracture intensities were determined by measuring the abrupt, sequential reductions in stress produced during compression. Both distribution exponent and cumulative fracture stress correlated strongly with fracturability measured by other techniques, including fractal and Fourier analysis of stress-strain functions. Distribution parameters also indicated textural differences due to process parameters (structural modification through addition of different levels of sucrose) and storage conditions (equilibration at various relative humidities). C1 WORCESTER POLYTECH INST,DEPT MATH SCI,WORCESTER,MA 01609. RP BARRETT, AH (reprint author), USA,NATICK RES DEV & ENGN CTR,SUSTAINABIL DIRECTORATE,ADV FOODS BRANCH,NATICK,MA 01760, USA. NR 16 TC 21 Z9 25 U1 0 U2 0 PU INST FOOD TECHNOLOGISTS PI CHICAGO PA SUITE 300 221 N LASALLE ST, CHICAGO, IL 60601-1291 SN 0022-1147 J9 J FOOD SCI JI J. Food Sci. PD MAY-JUN PY 1994 VL 59 IS 3 BP 617 EP 620 DI 10.1111/j.1365-2621.1994.tb05576.x PG 4 WC Food Science & Technology SC Food Science & Technology GA NW348 UT WOS:A1994NW34800040 ER PT J AU CORSON, MW MINGHI, JV AF CORSON, MW MINGHI, JV TI REUNIFICATION OF PARTITIONED NATION-STATES - THEORY VERSUS REALITY IN VIETNAM AND GERMANY SO JOURNAL OF GEOGRAPHY LA English DT Article DE PARTITION; REUNIFICATION; BORDERLANDS; VIETNAM; GERMANY ID UNIFICATION; EUROPE AB The absorption of the former German Democratic Republic into the German Federal Republic has drawn attention to the process of reunification of states partitioned as a result of the Cold War. While German reunification has already attracted political geographic study, no comparative analysis of the reunification process has yet been made. This study represents an initial attempt to point the way to a clearer understanding of the reunification process in formerly partitioned states by a comparative analysis in testing generalizations about the process. Three hypotheses are applied to two Cold War cases of partitioned nation-state reunification-Vietnam (1975-76) and Germany (1990). A winners-and-losers hypothesis addresses the fate of societal elites resulting from unification. A persistent-dissimilarities hypothesis contends that political, economic, and social differences and inequities will persist and cause stress between the two segments of the unifying societies. Finally, a borderlands-to-centrality hypothesis suggests that formerly peripheralized borderlands along the former partition line tend to become centers of circulation with the advent of reunification. The conclusion speculates on the applicability of these hypotheses to the possible future case of Korea. C1 UNIV S CAROLINA,DEPT GEOG,COLUMBIA,SC 29208. RP CORSON, MW (reprint author), US MIL ACAD,DEPT GEOG & ENVIRONM ENGN,W POINT,NY 10996, USA. NR 29 TC 3 Z9 3 U1 0 U2 1 PU NATL COUNCIL GEOGRAPHIC EDUCATION PI INDIANA PA INDIANA UNIV PENNSYLVANIA, INDIANA, PA 15705 SN 0022-1341 J9 J GEOGR JI J. Geogr. PD MAY-JUN PY 1994 VL 93 IS 3 BP 125 EP 131 DI 10.1080/00221349408979707 PG 7 WC Geography SC Geography GA NU633 UT WOS:A1994NU63300002 ER PT J AU DAI, WL WOODWARD, PR AF DAI, WL WOODWARD, PR TI 2-DIMENSIONAL SIMULATIONS FOR THE IMPULSIVE PENETRATION OF A SOLAR-WIND FILAMENT INTO THE MAGNETOSPHERE SO JOURNAL OF GEOPHYSICAL RESEARCH-SPACE PHYSICS LA English DT Article ID CONSERVATIVE DIFFERENCE SCHEME; PLASMA ELEMENTS; MAGNETOPAUSE AB In order to understand the penetration process of a solar wind filament into the magnetosphere in detail, a simplified two-dimensional PPMMHD code for ideal MHD is applied to the penetration. The filament is modeled as a field-aligned cylinder impinging on the dayside magnetosphere. The initial magnetopause is considered as a purely tangential discontinuity without width. The results in this paper show that a plasma filament in the magnetosheath with excess momentum density will penetrate through the magnetopause and become irregularity inside in the magnetosphere. This paper presents detailed pictures for the distribution and the evolution of the plasma mass density, thermal pressure, flow velocity, and magnetic field around the filament. The results in this paper confirm our expectation that the penetration in the case with antiparallel magnetic fields happens in the same way as in the case with parallel magnetic fields in the initial situations both without and with a diamagnetic current flowing on the surface of a filament under the approximation of two-dimensional ideal MHD. RP UNIV MINNESOTA, USA, HIGH PERFORMANCE COMP RES CTR, 1100 WASHINGTON AVE, SUITE 101, MINNEAPOLIS, MN 55415 USA. NR 13 TC 11 Z9 11 U1 0 U2 0 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 2169-9380 EI 2169-9402 J9 J GEOPHYS RES-SPACE JI J. Geophys. Res-Space Phys. PD MAY 1 PY 1994 VL 99 IS A5 BP 8577 EP 8584 DI 10.1029/93JA03026 PG 8 WC Astronomy & Astrophysics SC Astronomy & Astrophysics GA NK217 UT WOS:A1994NK21700010 ER PT J AU BURNETT, PR VANCOTT, TC POLONIS, VR REDFIELD, RR BIRX, DL AF BURNETT, PR VANCOTT, TC POLONIS, VR REDFIELD, RR BIRX, DL TI SERUM IGA-MEDIATED NEUTRALIZATION OF HIV TYPE-1 SO JOURNAL OF IMMUNOLOGY LA English DT Article ID HUMAN IMMUNODEFICIENCY VIRUS; B-CELL ACTIVATION; ANTIBODY-DEPENDENT ENHANCEMENT; IMMUNE-DEFICIENCY SYNDROME; LYMPHOTROPIC VIRUS; INFLUENZA-VIRUS; CLINICAL STATUS; HOMOSEXUAL MEN; PROTEIN-G; HTLV-III AB The sera of 33 HIV-1-infected individuals, previously shown to neutralize HIV-1(MN) in vitro, were screened by ELISA for IgA reactivity against rgpl20(MN) and a synthetic V3(MN) loop peptide. Six were selected for evaluation of the effect of serum IgA from infected individuals on the in vitro infection of susceptible target cells by HIV-1(MN). By using protein C immobilized on Sepharose, we depleted the sera of Ige to a level undetectable by nephelometry and viral envelope-specific ELISA. The IgA component of the IgG-depleted serum was affinity purified with immobilized jacalin, a lectin that selectively binds the IgA1 fraction of human Ig. Igc-depleted sera and purified IgA1 serum fractions showing IgA reactivity against rgp120(MN) and V3(MN) by ELISA inhibited the in vitro infection of CEM-ss cells by HIV-1(MN), but sera depleted of both IgG and IgA1 did not. These data show that, like serum IgG, serum IgA from selected HIV-1-infected individuals is capable of neutralizing HIV-1(MN) in vitro. The biologic significance of this observation and the identities of serum IgA-recognized HIV-1 neutralization epitopes remain to be determined. C1 USA,DENT RES DETACHMENT,WASHINGTON,DC 20307. RP BURNETT, PR (reprint author), WALTER REED ARMY INST RES,DEPT RETROVIRAL RES,DIV RETROVIROL,13 TAFT CT,SUITE 200,ROCKVILLE,MD 20850, USA. NR 50 TC 33 Z9 34 U1 0 U2 1 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD MAY 1 PY 1994 VL 152 IS 9 BP 4642 EP 4648 PG 7 WC Immunology SC Immunology GA NG719 UT WOS:A1994NG71900046 PM 8157978 ER PT J AU SAMUELSON, LA WILEY, B KAPLAN, DL SENGUPTA, S KAMATH, M LIM, JO CAZECA, M KUMAR, J MARX, KA TRIPATHY, SK AF SAMUELSON, LA WILEY, B KAPLAN, DL SENGUPTA, S KAMATH, M LIM, JO CAZECA, M KUMAR, J MARX, KA TRIPATHY, SK TI INTELLIGENT SYSTEMS BASED ON ORDERED ARRAYS OF BIOLOGICAL MOLECULES USING THE LB TECHNIQUE SO JOURNAL OF INTELLIGENT MATERIAL SYSTEMS AND STRUCTURES LA English DT Article ID SURFACE RECOGNITION; PURPLE MEMBRANE; STREPTAVIDIN; PHYCOBILISOMES; MONOLAYERS; FILMS AB The Langmuir-Blodgett (LB) technique has been used to incorporate photodynamic proteins into molecular assemblies. One technique of incorporation involves a generalized cassette attachment methodology which employs a biotin-streptavidin complexation with an electroactive polymer matrix. We have focused the efforts described here on phycobiliproteins and bacteriorhodopsin, although antibodies, enzymes, gene probes and other moieties could also be coupled into the system to build in selectivity. Photoconductivity and photobleaching of these protein systems were investigated. These results suggest that coupling these proteins, either in mixed monolayers or in multilayers, with appropriate conductive polymers or other materials will provide the optoelectronic signal transduction needed for biosensor, optical display and other applications. Initial studies involving the integration of conductive polymers into the molecular assemblies to enhance optical signal transduction are also discussed. C1 UNIV MASSACHUSETTS,DEPT CHEM,CTR ADV MAT,LOWELL,MA 01854. UNIV MASSACHUSETTS,DEPT PHYS,CTR ADV MAT,LOWELL,MA 01854. RP SAMUELSON, LA (reprint author), USA,NATICK RES,CTR DEV & ENGN,DIV BIOTECHNOL,NATICK,MA 01760, USA. NR 23 TC 8 Z9 8 U1 0 U2 0 PU TECHNOMIC PUBL CO INC PI LANCASTER PA 851 NEW HOLLAND AVE, BOX 3535, LANCASTER, PA 17604 SN 1045-389X J9 J INTEL MAT SYST STR JI J. Intell. Mater. Syst. Struct. PD MAY PY 1994 VL 5 IS 3 BP 305 EP 310 DI 10.1177/1045389X9400500302 PG 6 WC Materials Science, Multidisciplinary SC Materials Science GA NQ322 UT WOS:A1994NQ32200002 ER PT J AU PELLER, PJ HO, VB AF PELLER, PJ HO, VB TI THE INCIDENCE AND CLINICAL-SIGNIFICANCE ABNORMAL SOFT-TISSUE TC-99M METHYLENE DIPHOSPHONATE UPTAKE SO JOURNAL OF NUCLEAR MEDICINE LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SOC NUCLEAR MEDICINE INC PI RESTON PA 1850 SAMUEL MORSE DR, RESTON, VA 20190-5316 SN 0161-5505 J9 J NUCL MED JI J. Nucl. Med. PD MAY PY 1994 VL 35 IS 5 SU S BP P120 EP P120 PG 1 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA NK909 UT WOS:A1994NK90900479 ER PT J AU LAM, DM AF LAM, DM TI MALARIA PROPHYLAXIS REVISITED SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE LA English DT Letter RP LAM, DM (reprint author), USA,HEADQUARTERS V CORPS,UNIT 25202,APO,AE 09079, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 1076-2752 J9 J OCCUP ENVIRON MED JI J. Occup. Environ. Med. PD MAY PY 1994 VL 36 IS 5 BP 501 EP 502 PG 2 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA NZ164 UT WOS:A1994NZ16400002 PM 8027873 ER PT J AU GREATHOUSE, DG SCHRECK, RC BENSON, CJ AF GREATHOUSE, DG SCHRECK, RC BENSON, CJ TI THE UNITED-STATES-ARMY PHYSICAL THERAPY EXPERIENCE - EVALUATION AND TREATMENT OF PATIENTS WITH NEUROMUSCULOSKELETAL DISORDERS SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Article DE PHYSICAL THERAPY; ORTHOPEDICS; NEUROMUSCULOSKELETAL AB Army physical therapists have had unique experiences relevant to orthopaedic physical therapy. The educational process, expanded clinical privileges, and physician supervisor role as developed to prepare and support physical therapists working as primary neuromusculoskeletal screeners are summarized. After-action reports demonstrate that Army physical therapists can evaluate and treat one-third of all sick-call patients generated in field training missions and significantly improve return-to-duty rates without requiring physician intervention. The historic events that led to the physician-extender role in the evaluation and treatment of patients with neuromusculoskeletal conditions are presented. These events support the current battlefield assignment of physical therapists as far forward as the inflatable Combat Support Hospitals. The scope of Army physical therapy practice continues to evolve and expand to meet the new challenge of nation assistance, peace-keeping, and humanitarian missions. RP GREATHOUSE, DG (reprint author), USA,MED SPECIALIST CORPS,HQDA,DASG DB,5109 LEESBURG PIKE,FALLS CHURCH,VA 22041, USA. NR 0 TC 30 Z9 30 U1 0 U2 2 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0190-6011 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD MAY PY 1994 VL 19 IS 5 BP 261 EP 266 PG 6 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA NG922 UT WOS:A1994NG92200005 PM 8199619 ER PT J AU BRYAN, JM GEROY, GD ISERNHAGEN, SJ AF BRYAN, JM GEROY, GD ISERNHAGEN, SJ TI NONCLINICAL COMPETENCES - A SURVEY OF OCCUPATIONAL-HEALTH PHYSICAL-THERAPISTS SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Article DE COMPETENCES; OCCUPATIONAL HEALTH; PHYSICAL THERAPISTS AB Consulting with business and industry represents a very new world for physical therapists-a world in which most have had little formal academic preparation. Some competencies in consulting in occupational health physical therapy are beyond specific dinical skills and knowledge. The purpose of this research was to survey occupational health physical therapists (OHPTs) concerning a previously identified list of nonclinical competencies in consulting with business and industry. The survey addressed how OHPTs rated the importance of these competencies, how they rated their own level of competence for each, and how they developed these competencies. The survey sample was based on members of the American Physical Therapy Association Orthopaedic Section's Special Interest Group in Occupational Health Physical Therapy. The response rate was 98% (61/62). Mean importance of competencies was 3.66/4.00 (range 3.00-3.88), which further validated the list of nonclinical competencies. The mean level of competence was 3.17/4.00 (range 2.40-3.50). The mean importance of individual competencies was consistently higher than level of competence. This discrepancy is of practical significance in terms of professional development of OHPTs consulting with business and industry. Primary sources of competence were practical experience (59.87%) and continuing education for physical therapists (15.51%). These results may indicate that current continuing education programs are not meeting OHPTs' educational needs and may serve as a basis for developing programs to better meet these needs. The survey instrument may help OHPTs identify and prioritize their own educational needs and to plan their own professional development accordingly. RP BRYAN, JM (reprint author), BROOKE ARMY MED CTR,USA,MED SPECIALIST CORPS,FT SAM HOUSTON,TX 78234, USA. NR 0 TC 2 Z9 2 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0190-6011 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD MAY PY 1994 VL 19 IS 5 BP 305 EP 311 PG 7 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA NG922 UT WOS:A1994NG92200010 PM 8199624 ER PT J AU LEWICKI, DG HANDSCHUH, RF HENRY, ZS LITVIN, FL AF LEWICKI, DG HANDSCHUH, RF HENRY, ZS LITVIN, FL TI LOW-NOISE, HIGH-STRENGTH, SPIRAL-BEVEL GEARS FOR HELICOPTER TRANSMISSIONS SO JOURNAL OF PROPULSION AND POWER LA English DT Article AB Advanced-design spiral-bevel gears were tested in an OH-58D helicopter transmission using the NASA 500-hp Helicopter Transmission Test Stand. Three different gear designs tested included 1) the current design of the OH-58D transmission; 2) a higher-strength design the same as the current but with a full fillet radius to reduce gear tooth bending stress (and thus, weight); and 3) a lower-noise design the same as the high-strength but with modified tooth geometry to reduce transmission error and noise. Noise, vibration, and tooth strain tests were performed and significant gear stress and noise reductions were achieved. C1 BELL HELICOPTER TEXTRON INC,DR SYST DES GRP,FT WORTH,TX 76101. UNIV ILLINOIS,DEPT MECH ENGN,CHICAGO,IL 60680. RP LEWICKI, DG (reprint author), NASA,LEWIS RES CTR,USA RES LAB,VEHICLE PROPULS DIRECTORATE,CLEVELAND,OH 44135, USA. NR 14 TC 11 Z9 11 U1 0 U2 1 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091 SN 0748-4658 J9 J PROPUL POWER JI J. Propul. Power PD MAY-JUN PY 1994 VL 10 IS 3 BP 356 EP 361 DI 10.2514/3.23764 PG 6 WC Engineering, Aerospace SC Engineering GA NM077 UT WOS:A1994NM07700009 ER PT J AU VERMILYEA, SG PRASANNA, MK AGAR, JR AF VERMILYEA, SG PRASANNA, MK AGAR, JR TI EFFECT OF ULTRASONIC CLEANING AND AIR POLISHING ON PORCELAIN LABIAL MARGIN RESTORATIONS SO JOURNAL OF PROSTHETIC DENTISTRY LA English DT Article ID POWDER ABRASIVE INSTRUMENT; PROPHY-JET; ENAMEL; INTEGRITY; CROWNS AB This study examined porcelain labial margins after ultrasonic scaling and air polishing. Thirty metal coupons were covered with 1.5 mm thick shoulder porcelain and cemented to acrylic resin blocks. A reference mark divided each specimen into a ''treated'' and an ''untreated'' side. The specimens were treated as three groups with: (1) an air polisher; (2) an ultrasonic scaler, and (3) the ultrasonic scaler and the air polisher. Surface roughness was determined and selected specimens were observed under scanning electron microscope. Surface roughness ranged from 0.37 mum to 1.06 mum for the untreated sides and from 0.86 mum to 2.80 mum for the treated sides. Increases in roughness were 69% for the ultrasonic scaler/air-polisher; 127% for the air polisher, and 162% for the ultrasonic scaler. ANOVA indicated a significant difference between the treatments. Specimens treated with the air polisher or the ultrasonic scaler and air polisher combination were less distorted than those treated with the ultrasonic scaler alone. The data suggested that careless use of an ultrasonic scaler or air polisher could substantially alter porcelain facial margins. C1 OHIO STATE UNIV,COLL DENT,DEPT RESTORAT & PROSTHET DENT,COLUMBUS,OH 43210. WALTER REED ARMY MED CTR,DENT ACTIV,WASHINGTON,DC 20307. NR 23 TC 8 Z9 8 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0022-3913 J9 J PROSTHET DENT JI J. Prosthet. Dent. PD MAY PY 1994 VL 71 IS 5 BP 447 EP 452 DI 10.1016/0022-3913(94)90181-3 PG 6 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA NJ312 UT WOS:A1994NJ31200003 PM 8006838 ER PT J AU FOERSTER, JG MEYERS, RD BUTLER, GV BROUSSEAU, JS AF FOERSTER, JG MEYERS, RD BUTLER, GV BROUSSEAU, JS TI MIDPONTIC SOLDERING OF THE MODIFIED SANITARY PONTIC SO JOURNAL OF PROSTHETIC DENTISTRY LA English DT Note C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. RP FOERSTER, JG (reprint author), USA,N RIVERA RIDGE DENT CLIN,FT DRUM,NY 13602, USA. NR 5 TC 1 Z9 2 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0022-3913 J9 J PROSTHET DENT JI J. Prosthet. Dent. PD MAY PY 1994 VL 71 IS 5 BP 541 EP 541 DI 10.1016/0022-3913(94)90197-X PG 1 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA NJ312 UT WOS:A1994NJ31200019 PM 7911831 ER PT J AU NEWELL, TA SMITH, MK COWIE, RG UPPER, JM CLER, CL AF NEWELL, TA SMITH, MK COWIE, RG UPPER, JM CLER, CL TI CHARACTERISTICS OF A SOLAR POND BRINE RECONCENTRATION SYSTEM SO JOURNAL OF SOLAR ENERGY ENGINEERING-TRANSACTIONS OF THE ASME LA English DT Article AB An active brine reconcentration system has been incorporated into the design of the University of Illinois half-acre salt gradient solar pond facility. An important feature of the system is its ability to keep precipitation from diluting the brine. Experimental data presented is in good agreement with a numerical simulation model of the evaporation process. The ''film''-type evaporation process used in the system efficiently collects solar energy for evaporating water from brine. Parasitic electrical energy requirements for the evaporation system are 1.2 watts per square meter of evaporation surface area. C1 USA,CONSTRUCT ENGN,RES LAB,CHAMPAIGN,IL. RP NEWELL, TA (reprint author), UNIV ILLINOIS,DEPT MECH & IND ENGN,1206 W GREEN ST,URBANA,IL 61801, USA. NR 7 TC 8 Z9 8 U1 0 U2 3 PU ASME-AMER SOC MECHANICAL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 SN 0199-6231 J9 J SOL ENERG-T ASME JI J. Sol. Energy Eng. Trans.-ASME PD MAY PY 1994 VL 116 IS 2 BP 69 EP 73 DI 10.1115/1.2930500 PG 5 WC Energy & Fuels; Engineering, Mechanical SC Energy & Fuels; Engineering GA NM847 UT WOS:A1994NM84700001 ER PT J AU HEFTER, GT SALOMON, M AF HEFTER, GT SALOMON, M TI CONDUCTIVITIES OF 1-1 SALTS IN 2-CYANOPYRIDINE SO JOURNAL OF SOLUTION CHEMISTRY LA English DT Article DE 2-CYANOPYRIDINE; CONDUCTIVITIES; 1-1 ELECTROLYTES; DILUTE SOLUTIONS; SINGLE ION MOLAR CONDUCTIVITIES; ION ASSOCIATION; MIXED SOLVENTS; ACETONITRILE; CONCENTRATED SOLUTIONS; LIASF6; HIGH ENERGY DENSITY LITHIUM BATTERIES ID PROPYLENE CARBONATE; ELECTROLYTE-SOLUTIONS; APROTIC-SOLVENTS; CONDUCTANCE; ACETONITRILE; TEMPERATURE; BATTERIES; WATER AB Electrolytic conductivities of eight simple 1:1 electrolytes have been measured in dilute solutions of 2-cyanopyridine (2CNP) at 30-degrees. Infinite dilution mobilities and association constants were calculated using the Fuoss-Hsia equation. With the exception of LiCF3SO3 all salts show very little association, consistent with the very high dielectric constant of 2CNP. The weak association which does occur is attributed to weak ion-solvent interactions. No evidence was found for triple ion formation. Conductivities of concentrated solutions of LiAsF6 in 2CNP increase slowly with concentration reaching a maximum at a concentration of around 0.65 mol-dm-3. These conductances are slightly lower than those in propylene carbonate which has a lower dielectric constant and a higher viscosity. Conductivities of concentrated LiAsF6 solutions in 2CNP mixtures with acetonitrile vary monotonically, consistent with solution viscosities, and show no sign of the maximum commonly observed in mixed organic solvents. C1 USA,EPSD,ARL,DIV POWER SOURCES,FT MONMOUTH,NJ 07703. MURDOCH UNIV,SCH MATH & PHYS SCI,MURDOCH,WA 6150,AUSTRALIA. NR 38 TC 9 Z9 9 U1 0 U2 1 PU PLENUM PUBL CORP PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 SN 0095-9782 J9 J SOLUTION CHEM JI J. Solut. Chem. PD MAY PY 1994 VL 23 IS 5 BP 579 EP 593 DI 10.1007/BF00972746 PG 15 WC Chemistry, Physical SC Chemistry GA NQ990 UT WOS:A1994NQ99000004 ER PT J AU CHOWDHURY, MR AF CHOWDHURY, MR TI NONLINEAR FINITE-ELEMENT MODEL FOR LIGHT-FRAME STUD WALLS - DISCUSSION SO JOURNAL OF STRUCTURAL ENGINEERING-ASCE LA English DT Discussion RP CHOWDHURY, MR (reprint author), USA,ENGR WTRWYS EXPT STN,3909 HALLS FERRY RD,CEWES SS-A,VICKSBURG,MS 39180, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU ASCE-AMER SOC CIVIL ENGINEERS PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-9445 J9 J STRUCT ENG-ASCE JI J. Struct. Eng.-ASCE PD MAY PY 1994 VL 120 IS 5 BP 1678 EP 1679 DI 10.1061/(ASCE)0733-9445(1994)120:5(1678) PG 2 WC Construction & Building Technology; Engineering, Civil SC Construction & Building Technology; Engineering GA NG738 UT WOS:A1994NG73800022 ER PT J AU SHOOP, S YOUNG, B ALGER, R DAVIS, J AF SHOOP, S YOUNG, B ALGER, R DAVIS, J TI EFFECT OF TEST METHOD ON WINTER TRACTION MEASUREMENTS SO JOURNAL OF TERRAMECHANICS LA English DT Article AB Traction on winter surfaces was measured using three instrumented vehicles, each designed to measure traction for a different purpose: vehicle mobility research (CRREL instrumented vehicle), commercial tire testing (Uniroyal-Goodrich traction tester), and airport runway safety (Saab friction tester). The traction measured with each method is comparable but there are systematic differences due to the effects of the surface materials and test and analysis techniques. This comparison serves as the basis for collaboration between the various traction testing communities and illustrates the need for well documented, standard test and analysis procedures for traction testing and evaluation. RP SHOOP, S (reprint author), USA,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 0 TC 6 Z9 6 U1 1 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0022-4898 J9 J TERRAMECHANICS JI J. Terramech. PD MAY PY 1994 VL 31 IS 3 BP 153 EP 161 DI 10.1016/0022-4898(94)90012-4 PG 9 WC Engineering, Environmental SC Engineering GA PE094 UT WOS:A1994PE09400001 ER PT J AU ELSMORE, TF MCBRIDE, SA AF ELSMORE, TF MCBRIDE, SA TI AN 8-ALTERNATIVE CONCURRENT SCHEDULE - FORAGING IN A RADIAL MAZE SO JOURNAL OF THE EXPERIMENTAL ANALYSIS OF BEHAVIOR LA English DT Article DE CONCURRENT SCHEDULES; MATCHING; FORAGING; INTERVAL REINFORCEMENT SCHEDULES; CHANGEOVER DELAY; TIMING; MAZE; NOSE POKE; RATS ID CHOICE; PERFORMANCE; BEHAVIOR; RAT AB In two experiments conducted in an eight-arm radial maze, food pellets were delivered when a photocell beam was broken at the end of each arm via a nose poke, according to either fixed-interval or random-interval schedules of reinforcement, with each arm providing a different frequency of reinforcement. The behavior of rats exposed to these procedures was well described by the generalized matching law; that is, the relationships between log behavior ratios and log pellet ratios were approximated by linear functions. The slopes of these log-log functions, an index of sensitivity to reinforcement frequency, were greatest for nose pokes, intermediate for lime spent in an arm, and least for arm entries. Similar results were obtained with both fixed-interval and random-interval schedules. Addition of a 10-s changeover delay in both experiments eliminated the slope differentials between nose pokes and time spent in an arm by reducing the slopes of the nose-poke functions. These results suggest that different aspects of foraging may be differentially sensitive to reinforcement frequency. With concurrent fixed-interval schedules, the degree of temporal control exerted by individual fixed-interval schedules was directly related to reinforcement frequency. C1 AMERICAN UNIV,WASHINGTON,DC 20016. RP ELSMORE, TF (reprint author), WALTER REED ARMY INST RES,DIV NEUROPSYCHIAT,WASHINGTON,DC 20307, USA. NR 26 TC 11 Z9 11 U1 1 U2 3 PU SOC EXP ANALYSIS BEHAVIOR INC PI BLOOMINGTON PA INDIANA UNIV DEPT PSYCHOLOGY, BLOOMINGTON, IN 47405 SN 0022-5002 J9 J EXP ANAL BEHAV JI J. Exp. Anal. Behav. PD MAY PY 1994 VL 61 IS 3 BP 331 EP 348 DI 10.1901/jeab.1994.61-331 PG 18 WC Psychology, Biological; Behavioral Sciences; Psychology, Experimental SC Psychology; Behavioral Sciences GA NK204 UT WOS:A1994NK20400001 PM 8207350 ER PT J AU ANDREWS, LC MILLER, WB RICKLIN, JC AF ANDREWS, LC MILLER, WB RICKLIN, JC TI SPATIAL COHERENCE OF A GAUSSIAN-BEAM WAVE IN WEAK AND STRONG OPTICAL TURBULENCE SO JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION LA English DT Article ID PROPAGATION; SYSTEMS AB A generalized Huygens - Fresnel integral, valid for optical wave propagation through random inhomogeneities in the presence of any complex optical system characterized by an ABCD ray matrix, is used to derive a general expression for the mutual coherence function (MCF) associated with a Gaussian-beam wave in the weak-fluctuation regime. The mean irradiance obtained from this expression shows excellent agreement with all known asymptotic relations. By introducing a pair of effective beam parameters THETA(t) and LAMBDA(t) that account for additional diffraction on the receiving aperture, resulting from turbulence, the normalized MCF and the related degree of coherence are formally extended into the regime of strong fluctuations. Results for the normalized MCF from this heuristic approach compare well with numerical calculations obtained directly from the formal solution of the parabolic equation. Also, the implied spatial coherence length from this analysis in moderate-to-strong-fluctuation regimes generally agrees more closely with numerical solutions of the parabolic equation than do previous approximate solutions. All calculations are based on the modified von Karman spectrum for direct comparison with established results. C1 UNIV CENT FLORIDA,DEPT ELECT & COMP ENGN,ORLANDO,FL 32816. USA,RES LAB,BATTLEFIELD ENVIRONM DIRECTORATE,WHITE SANDS MISSILE RANGE,NM 88002. RP ANDREWS, LC (reprint author), UNIV CENT FLORIDA,DEPT MATH,ORLANDO,FL 32816, USA. NR 25 TC 34 Z9 37 U1 0 U2 3 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0740-3232 J9 J OPT SOC AM A JI J. Opt. Soc. Am. A-Opt. Image Sci. Vis. PD MAY PY 1994 VL 11 IS 5 BP 1653 EP 1660 DI 10.1364/JOSAA.11.001653 PG 8 WC Optics SC Optics GA NK239 UT WOS:A1994NK23900013 ER PT J AU SCALORA, M AF SCALORA, M TI DISPERSION AND SOLITON PROPAGATION IN STIMULATED RAMAN-SCATTERING SO JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICS LA English DT Article ID ANTI-STOKES GENERATION; SELF-PHASE MODULATION; OPTICAL FIBERS; QUANTUM NOISE; DECAY; WAVES; TRANSIENT AB I discuss the role of group-velocity dispersion when a soliton propagates in a Raman-active medium. Using a modified beam-propagation method, I generate a pump soliton by inducing a phase shift of order ir in an input Stokes seed. As the pulses propagate with different velocities because of the frequency dependence of the refractive index, pulse walk-off effects cause the soliton to decay and to break up. This gives rise to a new effect: the generation of a Stokes pulse whose width is comparable with the pump soliton width and whose height may be a factor of 2 larger than the maximum input pump field amplitude. RP SCALORA, M (reprint author), USA,MISSILE COMMAND,CTR RES DEV & ENGN,WEAP SCI DIRECTORATE,REDSTONE ARSENAL,AL 35898, USA. NR 22 TC 9 Z9 10 U1 0 U2 0 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0740-3224 J9 J OPT SOC AM B JI J. Opt. Soc. Am. B-Opt. Phys. PD MAY PY 1994 VL 11 IS 5 BP 770 EP 773 DI 10.1364/JOSAB.11.000770 PG 4 WC Optics SC Optics GA NL959 UT WOS:A1994NL95900010 ER PT J AU KUHN, EJ SKOOG, SJ NICELY, ER AF KUHN, EJ SKOOG, SJ NICELY, ER TI THE POSTERIOR SAGITTAL PARARECTAL APPROACH TO POSTERIOR URETHRAL ANOMALIES SO JOURNAL OF UROLOGY LA English DT Article DE SACCULE AND UTRICULE; SURGERY, OPERATIVE ID HYPOSPADIAS; CYSTS AB We report a case of enlarged symptomatic utricle that was excised using a posterior sagittal pararectal approach. This surgical approach provides direct access to the posterior urethra to permit complete resection of the utricle and optimal exposure for accurate urethral repair. C1 WALTER REED ARMY MED CTR,DEPT UROL,WASHINGTON,DC 20307. NR 13 TC 14 Z9 15 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-5347 J9 J UROLOGY JI J. Urol. PD MAY PY 1994 VL 151 IS 5 BP 1365 EP 1367 PG 3 WC Urology & Nephrology SC Urology & Nephrology GA NG390 UT WOS:A1994NG39000063 PM 8158791 ER PT J AU MICHAEL, NL DARCY, L EHRENBERG, PK REDFIELD, RR AF MICHAEL, NL DARCY, L EHRENBERG, PK REDFIELD, RR TI NATURALLY-OCCURRING GENOTYPES OF THE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 LONG TERMINAL REPEAT DISPLAY A WIDE-RANGE OF BASAL AND TAT-INDUCED TRANSCRIPTIONAL ACTIVITIES SO JOURNAL OF VIROLOGY LA English DT Article ID LONG TERMINAL REPEAT; TRANS-ACTIVATOR PROTEIN; HIV-1 GENE-EXPRESSION; T-CELL; HTLV-III; AIDS; RNA; SEQUENCE; INFECTION; INVIVO AB The primary body of information on the structure of human immunodeficiency virus type 1 (HIV-1) long terminal repeat (LTR)/gag leader genotypes has been determined from the analysis of cocultivated isolates. Functional studies of this regulatory portion of the provirus have been derived from the study of in vitro-generated mutations of laboratory-adapted molecular clones of HIV-1. We have performed a longitudinal analysis of molecular clones from the LTR/gag leader region amplified directly from the peripheral blood of four patients over three years. We have found a remarkable number of point mutations and length polymorphisms in cis- and trans-acting regulatory elements within this cohort. Most of the length polymerphisms were associated with duplications of Sp1 and TCF-1 alpha sequences. These mutations were associated with a wide range of transcriptional activities for these genotypes in a reporter gene assay. Mutations in conserved Sp1 sequences correlated with a diminished capacity of such genotypes to bind purified Sp1 protein. Although no generalized trend in transcriptional activity was seen, a single patient accumulated mutations in NF-KB, Sp1, and TAR elements over this period. The analysis of naturally occurring mutations of LTR genotypes provides a means to study the molecular genetic consequences of virus-host interactions and to assess the functional impact of HIV therapeutics. C1 WALTER REED ARMY INST RES,DIV RETROVIROL,ROCKVILLE,MD. HENRY M JACKSON FDN,ROCKVILLE,MD. NR 54 TC 70 Z9 70 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0022-538X J9 J VIROL JI J. Virol. PD MAY PY 1994 VL 68 IS 5 BP 3163 EP 3174 PG 12 WC Virology SC Virology GA NF452 UT WOS:A1994NF45200043 PM 7908701 ER PT J AU SLINEY, DH AF SLINEY, DH TI LASER SAFETY CONCEPTS ARE CHANGING SO LASER FOCUS WORLD LA English DT Article RP SLINEY, DH (reprint author), USA,ENVIRONM HYG AGCY,DIV LASER MICROWAVE,LASER BRANCH,ABERDEEN PROVING GROUND,MD 21010, USA. NR 2 TC 3 Z9 5 U1 0 U2 0 PU PENNWELL PUBL CO PI NASHUA PA 5TH FLOOR TEN TARA BOULEVARD, NASHUA, NH 03062-2801 SN 0740-2511 J9 LASER FOCUS WORLD JI Laser Focus World PD MAY PY 1994 VL 30 IS 5 BP 185 EP & PG 0 WC Optics SC Optics GA NK624 UT WOS:A1994NK62400036 ER PT J AU BARTH, J AF BARTH, J TI THE MUTUAL FUND BUYERS GUIDE, 1994 - FOSBACK,NG SO LIBRARY JOURNAL LA English DT Book Review RP BARTH, J (reprint author), US MIL ACAD LIB,W POINT,NY, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 SN 0363-0277 J9 LIBR J JI Libr. J. PD MAY 1 PY 1994 VL 119 IS 8 BP 116 EP 116 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA NJ351 UT WOS:A1994NJ35100109 ER PT J AU BURGESS, EB AF BURGESS, EB TI WHITE HARVEST - CHARBONNEAU,L SO LIBRARY JOURNAL LA English DT Book Review RP BURGESS, EB (reprint author), USA,CTR TRALINET,FT MONROE,VA, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 SN 0363-0277 J9 LIBR J JI Libr. J. PD MAY 1 PY 1994 VL 119 IS 8 BP 135 EP 135 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA NJ351 UT WOS:A1994NJ35100209 ER PT J AU CARLIN, K CARLIN, S AF CARLIN, K CARLIN, S TI DISEASED CELLS AND PH SO MEDICAL HYPOTHESES LA English DT Article ID INTRACELLULAR PH; BONE-RESORPTION; PROTON PUMP; ACID-BASE; ACIDIFICATION; MACROPHAGES; METABOLISM; APOPTOSIS; INFECTION; EXCHANGE AB Diseased cells may alter their intracellular pH. This could explain such diverse activities as resistance to hormones, resistance to medications, and preferential metastasis to the same locations. RP CARLIN, K (reprint author), BROOKE ARMY MED CTR,DEPT ENDOCRINOL,SAN ANTONIO,TX 78234, USA. NR 46 TC 4 Z9 4 U1 0 U2 0 PU CHURCHILL LIVINGSTONE PI EDINBURGH PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE, LEITH WALK, EDINBURGH, MIDLOTHIAN, SCOTLAND EH1 3AF SN 0306-9877 J9 MED HYPOTHESES JI Med. Hypotheses PD MAY PY 1994 VL 42 IS 5 BP 299 EP 306 DI 10.1016/0306-9877(94)90003-5 PG 8 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA NM554 UT WOS:A1994NM55400003 PM 7935071 ER PT J AU RITCHIE, C RUCK, DC ANDERSON, MW AF RITCHIE, C RUCK, DC ANDERSON, MW TI THE 528TH COMBAT STRESS-CONTROL UNIT IN SOMALIA IN SUPPORT OF OPERATION-RESTORE-HOPE SO MILITARY MEDICINE LA English DT Article AB The 528th Combat Stress Control (CSC) Unit activated on December 16, 1992, and deployed to Somalia in support of Operation Restore Hope on January 6, 1993. The experiences of the first 90 days are discussed, to include (1) deployment issues, (2) stresses facing the troops in Somalia, and (3) patient data. The CSC had expected to work with service members traumatized by the sight of starving children and dead bodies. Instead, the stresses were similar to those of low-intensity guerrilla war-fare. Overall there were very few soldiers and marines impaired by mental health issues, and minimal psychiatric evacuations from the theater. RP RITCHIE, C (reprint author), WALTER REED ARMY MED CTR, DEPT PSYCHIAT, WASHINGTON, DC USA. NR 0 TC 9 Z9 9 U1 0 U2 0 PU ASSOC MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA SN 0026-4075 EI 1930-613X J9 MIL MED JI Milit. Med. PD MAY PY 1994 VL 159 IS 5 BP 372 EP 376 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA PH155 UT WOS:A1994PH15500006 ER PT J AU HANSEN, MO POLLY, DW MCHALE, KA ASPLUND, LM AF HANSEN, MO POLLY, DW MCHALE, KA ASPLUND, LM TI A PROSPECTIVE EVALUATION OF ORTHOPEDIC PATIENTS EVACUATED FROM OPERATIONS DESERT SHIELD AND DESERT-STORM - THE WALTER REED EXPERIENCE SO MILITARY MEDICINE LA English DT Article AB A prospective review of all orthopedic casualties received from the southwest Asia theater of operations during Operations Desert Shield and Desert Storm was carried out at Walter Reed Army Medical Center. An injury analysis of the 181 orthopedic patients revealed 143 total fractures in 69 patients, with the remaining patients sustaining soft tissue injuries from trauma, overuse, or pre-existing conditions. Seventy percent of the fractures were open, of which 23% were treated with external fixators and 41% eventually underwent an operative stabilization procedure. An analysis of the distribution of injuries is given as well as the incidence of amputations, nerve injuries, and arterial injuries. Early multidisciplinary involvement in the care of these casualties proved to be greatly beneficial. RP HANSEN, MO (reprint author), WALTER REED ARMY MED CTR,ORTHOPAED SURG SERV,WASHINGTON,DC 20307, USA. NR 0 TC 20 Z9 20 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAY PY 1994 VL 159 IS 5 BP 376 EP 380 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA PH155 UT WOS:A1994PH15500007 PM 14620405 ER PT J AU LOTT, CM AF LOTT, CM TI THE CASE FOR MANDATORY HIV TESTING OF ACTIVE-DUTY SEX OFFENDERS SO MILITARY MEDICINE LA English DT Article AB As of May 1993, at least 23 states had passed laws permitting, or requiring, human immunodeficiency virus testing of sexual offenders. Several others have recently passed, or are considering, such legislation. At present, no such specific requirement exists under the Uniform Code of Military Justice. This paper presents an overview of the competing Fourth Amendment privacy rights of accused/convicted offenders, victims' rights, the usefulness and validity of such testing, and the public health mission of the military medical services. In addition, potential tort liability of the armed services is discussed. The author presents arguments supporting mandatory testing of accused offenders meeting minimal ''probable cause'' requirements, and sharing test results with the physician of complainants/victims. RP LOTT, CM (reprint author), USA,MED DEPT ACT,DIV PERSONNEL,FT RILEY,KS 66442, USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAY PY 1994 VL 159 IS 5 BP 386 EP 389 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA PH155 UT WOS:A1994PH15500010 PM 14620408 ER PT J AU JEFFER, EK AF JEFFER, EK TI MEDICAL TRIAGE IN THE POST-COLD-WAR ERA SO MILITARY MEDICINE LA English DT Article AB Military medicine is caught at the confluence of two major currents of change. The Department of Defense and the American system of health care are both undergoing major revisions. Triage was a key operational concept for patient care during the Cold War era. With the changed world situation, the author suggests new operational concepts including the relegation of triage to a marginal role in wartime care. The author argues that increasing the ratio of medical personnel to combat troops is consistent with a changed national perspective on wartime casualties. RP JEFFER, EK (reprint author), USA,NATL GUARD,111 S GEORGE MASON DR,ARLINGTON,VA 22204, USA. NR 0 TC 2 Z9 2 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAY PY 1994 VL 159 IS 5 BP 389 EP 391 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA PH155 UT WOS:A1994PH15500011 PM 14620409 ER PT J AU SCHOMER, PD LUZ, GA AF SCHOMER, PD LUZ, GA TI A REVISED STATISTICAL-ANALYSIS OF BLAST SOUND-PROPAGATION SO NOISE CONTROL ENGINEERING JOURNAL LA English DT Article AB As is well known, sound propagation over long distances is greatly influenced by the land surface and weather conditions. Sound velocity varies with weather conditions, primarily air temperature and wind velocity. Schomer et al. presented a rather coarse statistical analysis of C-weighted sound exposure levels from blast sounds propagated over distances along the ground ranging from 3.2 to 24 km in a 1978 article in J. Acoust. Soc. Am. The purpose of that analysis was to enable the prediction of C-weighted day-night average sound levels in the vicinity of Army installations. The present article contains an improved statistical presentation of the 1978 data. In this new presentation, all of the data at each distance (including sound exposure levels too low to be measured) are treated as if they were part of two normal distributions; a higher- and a lower-level distribution. The mean values of the sound exposure levels and the standard deviations of the two distributions are described by equations which can be used to predict C-weighted sound exposure level (CSEL) received in a community from distant blast sound sources. Because the distributions are Gaussian, one can predict the ''energy-averaged'' CSEL, or some more complicated acoustical measure, from the means, the standard deviations, and the percentage of blast sounds belonging to the higher-level distribution. RP SCHOMER, PD (reprint author), USA,CONSTRUCT ENGN RES LABS,POB 9005,CHAMPAIGN,IL 61826, USA. NR 0 TC 9 Z9 9 U1 0 U2 1 PU INST NOISE CONTROL ENG PI POUGHKEEPSIE PA PO BOX 3206 ARLINGTON BRANCH, POUGHKEEPSIE, NY 12603 SN 0736-2501 J9 NOISE CONTROL ENG JI Noise Control Eng. J. PD MAY-JUN PY 1994 VL 42 IS 3 BP 95 EP 100 DI 10.3397/1.2827872 PG 6 WC Acoustics; Engineering, Multidisciplinary SC Acoustics; Engineering GA NU310 UT WOS:A1994NU31000002 ER PT J AU BAGLEY, A WAKEFIELD, CW ROBBINS, JW AF BAGLEY, A WAKEFIELD, CW ROBBINS, JW TI IN-VITRO COMPARISON OF FILLED AND UNFILLED UNIVERSAL BONDING AGENTS OF AMALGAM TO DENTIN SO OPERATIVE DENTISTRY LA English DT Article AB In this study, four different adhesive amalgam systems were compared (Amalgambond Plus, Amalgambond Plus with HPA, All-Bond 2, and All-Bond 2 with Liner-F) regarding their ability to bond amalgam to freshly prepared dentinal surfaces. The two groups that yielded the highest mean bond strengths, Amalgambond Plus with HPA and All-Bond 2 with Liner-F, were the only two groups in comparison that were not statistically different (P > 0.05). The use of the filled resin bonding agents created significantly higher bond strengths between tooth and freshly triturated amalgam than the unfilled resin bonding agents. Further study is required to determine: a) the exact nature and mechanism of the bonds, and b) clinical in vivo presence and longevity of the bonds. RP BAGLEY, A (reprint author), USA,DENT CORPS,DENTAC,FT HOOD,TX 76544, USA. NR 0 TC 26 Z9 26 U1 0 U2 0 PU UNIV WASHINGTON PI SEATTLE PA SCHOOL DENTISTRY SM-57, SEATTLE, WA 98195 SN 0361-7734 J9 OPER DENT JI Oper. Dent. PD MAY-JUN PY 1994 VL 19 IS 3 BP 97 EP 101 PG 5 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA NM874 UT WOS:A1994NM87400004 PM 9028247 ER PT J AU BASS, JW WITTLER, RR AF BASS, JW WITTLER, RR TI RETURN OF EPIDEMIC PERTUSSIS IN THE UNITED-STATES SO PEDIATRIC INFECTIOUS DISEASE JOURNAL LA English DT Article DE PERTUSSIS; ACELLULAR PERTUSSIS VACCINE ID INFECTION; INFANTS; VACCINE C1 FITZSIMONS ARMY MED CTR,DENVER,CO. RP BASS, JW (reprint author), TRIPLER ARMY MED CTR,DEPT PEDIAT,HONOLULU,HI 96859, USA. NR 24 TC 89 Z9 96 U1 1 U2 2 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0891-3668 J9 PEDIATR INFECT DIS J JI Pediatr. Infect. Dis. J. PD MAY PY 1994 VL 13 IS 5 BP 343 EP 345 DI 10.1097/00006454-199405000-00002 PG 3 WC Immunology; Infectious Diseases; Pediatrics SC Immunology; Infectious Diseases; Pediatrics GA NL215 UT WOS:A1994NL21500001 PM 8072813 ER PT J AU CHOI, YS AF CHOI, YS TI SEXUALITY EDUCATION IN SCHOOLS SO PEDIATRICS LA English DT Letter RP CHOI, YS (reprint author), WOMACK ARMY MED CTR,DEPT MED & PEDIAT,FT BRAGG,NC 28307, USA. NR 3 TC 0 Z9 0 U1 0 U2 2 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD, ELK GROVE VILLAGE, IL 60007-1098 SN 0031-4005 J9 PEDIATRICS JI Pediatrics PD MAY PY 1994 VL 93 IS 5 BP 871 EP 871 PG 1 WC Pediatrics SC Pediatrics GA NJ374 UT WOS:A1994NJ37400046 PM 8165105 ER PT J AU BANNOV, N MITIN, V STROSCIO, M AF BANNOV, N MITIN, V STROSCIO, M TI CONFINED ACOUSTIC PHONONS IN A FREESTANDING QUANTUM-WELL AND THEIR INTERACTION WITH ELECTRONS SO PHYSICA STATUS SOLIDI B-BASIC RESEARCH LA English DT Article ID 2 INTERFACES; MODES; SYSTEMS; WIRES; EXISTENCE; DYNAMICS; WAVES AB The Lagrangian of an isotropic continuous medium and Lagrangian formalism are used to consistently derive acoustic eigenmodes, to normalize them, and to determine the acoustic phonons (confined acoustic phonons) in a free-standing quantum well. These phonons may be classified as shear, dilatational, and flexural phonons in accordance with the acoustic terminology for eigenmodes. The Hamiltonians describing interactions of the confined acoustic phonons with electrons in the approximations of the deformation potential and the piezoelectric scattering potential are obtained and analyzed. C1 USA,RES OFF,RES TRIANGLE PK,NC 27709. RP BANNOV, N (reprint author), WAYNE STATE UNIV,DEPT ELECT & COMP ENGN,DETROIT,MI 48202, USA. NR 23 TC 52 Z9 52 U1 0 U2 3 PU AKADEMIE VERLAG GMBH PI BERLIN PA MUHLENSTRASSE 33-34, D-13187 BERLIN, GERMANY SN 0370-1972 J9 PHYS STATUS SOLIDI B JI Phys. Status Solidi B-Basic Res. PD MAY PY 1994 VL 183 IS 1 BP 131 EP 142 DI 10.1002/pssb.2221830109 PG 12 WC Physics, Condensed Matter SC Physics GA NP923 UT WOS:A1994NP92300008 ER PT J AU DOWLING, JP AGARWAL, GS SCHLEICH, WP AF DOWLING, JP AGARWAL, GS SCHLEICH, WP TI WIGNER DISTRIBUTION OF A GENERAL ANGULAR-MOMENTUM STATE - APPLICATIONS TO A COLLECTION OF 2-LEVEL ATOMS SO PHYSICAL REVIEW A LA English DT Article ID COHERENT STATES; QUANTUM-OPTICS; PHASE-SPACE; INTERFERENCE; BEHAVIOR; NOISE AB The general theory of quantum angular momentum is used to derive the unique Wigner distribution function for arbitrary angular-momentum states. We give the explicit distribution for atomic angular-momentum Dicke states, coherent states, and squeezed states that correspond to a collection of N two-level atoms. These Wigner functions W(theta,phi)) are represented as a pseudoprobability distribution in spherical phase space with spherical coordinates theta and phi on the surface of a sphere of radius HBAR square-root j(j + 1) where j is the total angular-momentum eigenvalue. C1 UNIV HYDERABAD,SCH PHYS,HYDERABAD 500134,ANDHRA PRADESH,INDIA. UNIV ULM,QUANTENPHYS ABT,D-89069 ULM,GERMANY. MAX PLANCK INST QUANTUM OPT,D-85748 GARCHING,GERMANY. RP DOWLING, JP (reprint author), USA,MISSILE COMMAND,CTR RES DEV & ENGN,AMSMI RD WS ST,WEAP SCI DIRECTORATE,REDSTONE ARSENAL,AL 35898, USA. RI DOWLING, JONATHAN/L-2749-2013 NR 28 TC 124 Z9 124 U1 0 U2 6 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1050-2947 J9 PHYS REV A JI Phys. Rev. A PD MAY PY 1994 VL 49 IS 5 BP 4101 EP 4109 DI 10.1103/PhysRevA.49.4101 PN B PG 9 WC Optics; Physics, Atomic, Molecular & Chemical SC Optics; Physics GA NL386 UT WOS:A1994NL38600034 ER PT J AU MAPOU, RL LAW, WA AF MAPOU, RL LAW, WA TI NEUROBEHAVIORAL ASPECTS OF HIV DISEASE AND AIDS - AN UPDATE SO PROFESSIONAL PSYCHOLOGY-RESEARCH AND PRACTICE LA English DT Article; Proceedings Paper CT Annual Army-Medical-Department Psychology Short Course CY JUN, 1993 CL WASHINGTON, DC SP USA MED DEPT ID HUMAN-IMMUNODEFICIENCY-VIRUS; SEROPOSITIVE ASYMPTOMATIC INDIVIDUALS; DEMENTIA COMPLEX; CEREBROSPINAL-FLUID; NEUROPSYCHOLOGICAL PERFORMANCE; HOMOSEXUAL MEN; COGNITIVE IMPAIRMENT; INFECTED INDIVIDUALS; ZIDOVUDINE TREATMENT; QUINOLINIC ACID AB Recent research has continued to add to knowledge about AIDS Dementia Complex (ADC) and HIV-associated neurobehavioral difficulties. This article supplements Greenwood's (1991) article on ADC and summarizes recent literature relevant to clinical psychologists, including staging of HIV disease and its relation to neurobehavioral findings, knowledge about neurological and neuro-psychological complications of HIV disease, new data regarding the prevalence of ADC, and proposed changes in nomenclature for HIV-associated neurobehavioral disorders. Application of this knowledge to differential diagnosis and treatment also will be discussed. C1 UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. GEORGETOWN UNIV,SCH MED,WASHINGTON,DC 20057. RP MAPOU, RL (reprint author), WALTER REED ARMY MED CTR,HENRY M JACKSON FDN ADV MIL MED,HIV BEHAV PREVENT PROGRAM,WASHINGTON,DC 20307, USA. NR 86 TC 7 Z9 7 U1 1 U2 1 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 SN 0735-7028 J9 PROF PSYCHOL-RES PR JI Prof. Psychol.-Res. Pract. PD MAY PY 1994 VL 25 IS 2 BP 132 EP 140 PG 9 WC Psychology, Multidisciplinary SC Psychology GA NL399 UT WOS:A1994NL39900007 ER PT J AU TSEDILINA, EE WEITSMAN, OV SOICHER, H AF TSEDILINA, EE WEITSMAN, OV SOICHER, H TI TIME-DELAY OF TRANSIONOSPHERIC RADIO SIGNALS IN A HORIZONTALLY INHOMOGENEOUS IONOSPHERE SO RADIO SCIENCE LA English DT Article ID TOTAL ELECTRON-CONTENT AB The influence of a horizontally inhomogeneous ionosphere on time delay of satellite-emitted transionospheric radio signals is considered. Theoretical and numerical time delay calculations are performed using a single parabolic ionospheric density model along the signal radio path. The comparison of this method of calculation of signal time delay in the ionosphere with an approximate one, which does not consider horizontal density gradients is given. It is shown that during sunrise, in the regions of equatorial anomaly and midlatitude trough, the errors of the approximate method can be of the order 20-40%. C1 USA,COMMUN ELECTR COMMAND,FT KNOX,KY 40121. RP TSEDILINA, EE (reprint author), TEL AVIV UNIV,DEPT GEOPHYS & PLANETARY SCI,IL-69978 TEL AVIV,ISRAEL. NR 20 TC 4 Z9 5 U1 0 U2 0 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 SN 0048-6604 J9 RADIO SCI JI Radio Sci. PD MAY-JUN PY 1994 VL 29 IS 3 BP 625 EP 630 DI 10.1029/93RS03589 PG 6 WC Astronomy & Astrophysics; Geochemistry & Geophysics; Meteorology & Atmospheric Sciences; Remote Sensing; Telecommunications SC Astronomy & Astrophysics; Geochemistry & Geophysics; Meteorology & Atmospheric Sciences; Remote Sensing; Telecommunications GA NQ900 UT WOS:A1994NQ90000008 ER PT J AU WHEELER, RJ LECROY, SR WHITLOCK, CH PURGOLD, GC SWANSON, JS AF WHEELER, RJ LECROY, SR WHITLOCK, CH PURGOLD, GC SWANSON, JS TI SURFACE CHARACTERISTICS FOR THE ALKALI FLATS AND DUNES REGIONS AT WHITE-SANDS-MISSILE-RANGE, NEW-MEXICO SO REMOTE SENSING OF ENVIRONMENT LA English DT Article ID CALIBRATION AB Two regions at White Sands Missile Range with different surface reflectance characteristics were studied from November 1988 through December 1991. Continuous 6-min measurements of surface albedo on the alkali flats were used to produce a clear-sky surface climatology for the period. Based on the flats measurements, estimates for a dunes albedo were made using calibrated satellite data. In addition to the surface albedo history, sample bidirectional reflectance characteristics in terms of anisotropic factors for the alkali flats region are also presented. Results show that the flats region is non-Lambertian characterized by large anisotropic factors at high solar and viewing zenith angles. The flat's albedo is highly influenced by surface moisture conditions. Reflectance proper-ties of the dunes are complicated by dune shadows, surface irregularities, seasonal vegetative coverage, and soil moisture. C1 NASA,LANGLEY RES CTR,DIV ATMOSPHER SCI,HAMPTON,VA 23665. USA,RES LAB,WHITE SANDS MISSILE RANGE,NM 88002. RP WHEELER, RJ (reprint author), LOCKHEED ENGN & SCI CO,144 RES DR,HAMPTON,VA 23666, USA. NR 9 TC 14 Z9 15 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0034-4257 J9 REMOTE SENS ENVIRON JI Remote Sens. Environ. PD MAY PY 1994 VL 48 IS 2 BP 181 EP 190 DI 10.1016/0034-4257(94)90140-6 PG 10 WC Environmental Sciences; Remote Sensing; Imaging Science & Photographic Technology SC Environmental Sciences & Ecology; Remote Sensing; Imaging Science & Photographic Technology GA NN409 UT WOS:A1994NN40900007 ER PT J AU HE, J IAFRATE, GJ LITTLEJOHN, MA AF HE, J IAFRATE, GJ LITTLEJOHN, MA TI MULTIBAND THEORY OF BLOCH ELECTRON DYNAMICS IN ELECTRIC-FIELDS SO SEMICONDUCTOR SCIENCE AND TECHNOLOGY LA English DT Article; Proceedings Paper CT 8th International Conference on Hot Carriers in Semiconductors CY AUG 16-20, 1993 CL OXFORD UNIV, OXFORD, ENGLAND SP SCI & ENGN RES COUNCIL, ROYAL SOC, BRIT COUNCIL, OXFORD UNIV HO OXFORD UNIV AB A novel multiband theory of Bloch electron dynamics in homogeneous electric fields of arbitrary strength and time dependence is presented. In this formalism, the electric field is described through the use of the vector potential. Multiband coupling is treated through the use of the Wigner-Weisskopf approximation, thus allowing for a Bloch electron transition out of the initial band due to the power absorbed by the electric field; also, the approximation ensures conservation of the total transition probability over the complete set of excited bands. The choice of the vector potential gauge leads to a natural set of extended time-dependent basis functions for describing Bloch electron dynamics in a homogeneous electric field; an associated basis set of localized, electric-field-dependent Wannier and related envelope functions are developed and utilized in the analysis to demonstrate the inherent localization manifest in Bloch dynamics in the presence of relatively strong electric fields. From the theory, a generalized Zener tunnelling time is derived in terms of the applied uniform electric field and the relevant band parameters. The analysis shows an electric-field-enhanced broadening of the excited state probability amplitudes, thus resulting in spatial lattice delocalization and the onset of smearing of discrete, Stark ladder and band-to-band transitions due to the presence of the electric field. In addition, the velocities of a Bloch oscillation will be observed only for the electron that is initially in a Bloch state before Zener tunnelling. Further, the influence of electric fields on resonant tunnelling structure is examined. C1 USA,RES OFF,RES TRIANGLE PK,NC 27709. RP HE, J (reprint author), N CAROLINA STATE UNIV,DEPT ELECT & COMP ENGN,RALEIGH,NC 27695, USA. NR 7 TC 1 Z9 1 U1 0 U2 1 PU IOP PUBLISHING LTD PI BRISTOL PA TECHNO HOUSE, REDCLIFFE WAY, BRISTOL, ENGLAND BS1 6NX SN 0268-1242 J9 SEMICOND SCI TECH JI Semicond. Sci. Technol. PD MAY PY 1994 VL 9 IS 5 SU S BP 815 EP 819 DI 10.1088/0268-1242/9/5S/113 PG 5 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Condensed Matter SC Engineering; Materials Science; Physics GA NM753 UT WOS:A1994NM75300113 ER PT J AU GRUBIN, HL GOVINDAN, TR STROSCIO, MA AF GRUBIN, HL GOVINDAN, TR STROSCIO, MA TI NANOSTRUCTURE DEVICE SIMULATIONS THROUGH THE QUANTUM LIOUVILLE EQUATION IN THE COORDINATE REPRESENTATION SO SEMICONDUCTOR SCIENCE AND TECHNOLOGY LA English DT Article; Proceedings Paper CT 8th International Conference on Hot Carriers in Semiconductors CY AUG 16-20, 1993 CL OXFORD UNIV, OXFORD, ENGLAND SP SCI & ENGN RES COUNCIL, ROYAL SOC, BRIT COUNCIL, OXFORD UNIV HO OXFORD UNIV ID TRANSPORT; BARRIER AB Algorithms for obtaining quantum distribution functions from the Liouville equation in the coordinate representations, incorporating dissipation, are applied to the current-voltage (IV) and capacitance-voltage (CV) relations of single-barrier structures. IV reveals signature charge distributions and energies in excess of equilibrium values; CV demonstrates a reliable means of delineating the width of the barrier. C1 USA,RES OFF,RES TRIANGLE PK,NC 27709. RP GRUBIN, HL (reprint author), SCI RES ASSOCIATES INC,GLASTONBURY,CT 06033, USA. NR 11 TC 1 Z9 1 U1 1 U2 1 PU IOP PUBLISHING LTD PI BRISTOL PA TECHNO HOUSE, REDCLIFFE WAY, BRISTOL, ENGLAND BS1 6NX SN 0268-1242 J9 SEMICOND SCI TECH JI Semicond. Sci. Technol. PD MAY PY 1994 VL 9 IS 5 SU S BP 859 EP 861 DI 10.1088/0268-1242/9/5S/124 PG 3 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Condensed Matter SC Engineering; Materials Science; Physics GA NM753 UT WOS:A1994NM75300124 ER PT J AU MICKEVICIUS, R GASKA, R MITIN, V STROSCIO, MA IAFRATE, GJ AF MICKEVICIUS, R GASKA, R MITIN, V STROSCIO, MA IAFRATE, GJ TI HOT PHONONS IN QUANTUM WIRES SO SEMICONDUCTOR SCIENCE AND TECHNOLOGY LA English DT Article; Proceedings Paper CT 8th International Conference on Hot Carriers in Semiconductors CY AUG 16-20, 1993 CL OXFORD UNIV, OXFORD, ENGLAND SP SCI & ENGN RES COUNCIL, ROYAL SOC, BRIT COUNCIL, OXFORD UNIV HO OXFORD UNIV ID ENERGY-LOSS AB We present results of Monte Carlo simulations of electron relaxation dynamics in rectangular GaAs quantum wires (QWIS) embedded in AlAs. Electron interactions with confined LO phonons, interface optical phonons, bulk-like acoustic phonons as well as non-equilibrium (hot) optical phonons have been taken into account. It has been found that hot phonons come into play at electron concentrations exceeding 10(5) cm-1. In QWIS electrons having appreciably different initial energies generate non-equilibrium phonons at different q-space regions which do not overlap. In turn, these phonons can be reabsorbed only by the electrons that have generated them. Consequently, hot-phonon effects become weaker as the energy distribution of excited electrons broadens. This result is in complete contrast to the case of bulk materials and quantum wells where the injected electron energy distribution virtually does not affect non-equilibrium phonon build-up and the reabsorption rate. C1 USA,RES OFF,RES TRIANGLE PK,NC 27709. RP MICKEVICIUS, R (reprint author), WAYNE STATE UNIV,DEPT ELECT & COMP ENGN,DETROIT,MI 48202, USA. NR 12 TC 5 Z9 5 U1 0 U2 0 PU IOP PUBLISHING LTD PI BRISTOL PA TECHNO HOUSE, REDCLIFFE WAY, BRISTOL, ENGLAND BS1 6NX SN 0268-1242 J9 SEMICOND SCI TECH JI Semicond. Sci. Technol. PD MAY PY 1994 VL 9 IS 5 SU S BP 889 EP 892 DI 10.1088/0268-1242/9/5S/132 PG 4 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Condensed Matter SC Engineering; Materials Science; Physics GA NM753 UT WOS:A1994NM75300132 ER PT J AU WU, JC WYBOURNE, MN BERVEN, C GOODNICK, SM SMITH, DD AF WU, JC WYBOURNE, MN BERVEN, C GOODNICK, SM SMITH, DD TI NEGATIVE DIFFERENTIAL CONDUCTANCE IN A LATERAL HOT-ELECTRON DEVICE SO SEMICONDUCTOR SCIENCE AND TECHNOLOGY LA English DT Article ID MULTILAYER HETEROSTRUCTURES; RESISTANCE; TRANSPORT; STATES AB We report on the observations of S-type negative differential conductance in the current-voltage characteristics of a pinched cavity quantum dot structure. An energy balance approach is used to explain the existence of bistable current-voltage characteristics due to thermal runaway of the hot carriers in the dot structure. This runaway is shown to arise from heating of carriers in the quantum dot by incident electrons injected over the barrier of the input constriction. The observed S-type negative differential conductance is controlled by a third-terminal gate bias, and may be turned on or off depending on the bias voltage. Thus the effect may be utilized to realize a multiterminal switching device. C1 USA, RES LAB, EPSD, AMSRL-EP-EF, FT MONMOUTH, NJ 07703 USA. OREGON STATE UNIV, DEPT ELECT & COMP ENGN, CORVALLIS, OR 97331 USA. RP UNIV OREGON, DEPT PHYS, EUGENE, OR 97403 USA. NR 18 TC 0 Z9 1 U1 1 U2 2 PU IOP PUBLISHING LTD PI BRISTOL PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND SN 0268-1242 EI 1361-6641 J9 SEMICOND SCI TECH JI Semicond. Sci. Technol. PD MAY PY 1994 VL 9 IS 5 SU S BP 922 EP 925 DI 10.1088/0268-1242/9/5S/140 PG 4 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Condensed Matter SC Engineering; Materials Science; Physics GA NM753 UT WOS:A1994NM75300140 ER PT J AU BRAWLEY, OW THOMPSON, IM AF BRAWLEY, OW THOMPSON, IM TI CHEMOPREVENTION OF PROSTATE-CANCER SO UROLOGY LA English DT Article ID ANDROGEN ABLATION THERAPY; PROGRAMMED CELL-DEATH; RAT VENTRAL PROSTATE; UNITED-STATES; ALPHA-DIFLUOROMETHYLORNITHINE; ORNITHINE DECARBOXYLASE; BETA-CAROTENE; DIET; MEN; EPIDEMIOLOGY C1 BROOKE ARMY MED CTR,SERV UROL,FT SAM HOUSTON,TX 78234. NCI,DIV CANC PREVENT & CONTROL,FT SAM HOUSTON,TX. NR 57 TC 29 Z9 29 U1 0 U2 0 PU CAHNERS PUBL CO PI NEW YORK PA 249 WEST 17 STREET, NEW YORK, NY 10011 SN 0090-4295 J9 UROLOGY JI UROLOGY PD MAY PY 1994 VL 43 IS 5 BP 594 EP 599 DI 10.1016/0090-4295(94)90169-4 PG 6 WC Urology & Nephrology SC Urology & Nephrology GA NJ426 UT WOS:A1994NJ42600002 PM 8165761 ER PT J AU TAYLOR, DN PHILLIP, DF ZAPOR, M TROFA, A VANDEVERG, L HARTMAN, A BENDIUK, N NEWLAND, JW FORMAL, SB SADOFF, JC HALE, TL AF TAYLOR, DN PHILLIP, DF ZAPOR, M TROFA, A VANDEVERG, L HARTMAN, A BENDIUK, N NEWLAND, JW FORMAL, SB SADOFF, JC HALE, TL TI OUTPATIENT STUDIES OF THE SAFETY AND IMMUNOGENICITY OF AN AUXOTROPHIC ESCHERICHIA-COLI K-12 SHIGELLA-FLEXNERI 2A HYBRID VACCINE CANDIDATE, ECSF2A-2 SO VACCINE LA English DT Article DE ESCHERICHIA COLI SHIGELLA HYBRID VACCINE; PHASE II STUDY; ANTIBODY-SECRETING CELLS; ELISA; MUCOSAL IMMUNIZATION ID RESISTANT SHIGELLA; SOMATIC ANTIGEN; INFECTION; MONKEYS; THAILAND; EFFICACY; STRAINS; SONNEI; HUMANS AB A phase II study was conducted in 244 volunteers at Fort Ord, CA, to determine the safety and immunogenicity of EcSf2a-2, a live, oral Shigella vaccine constructed by transfer of genes from Shigella flexneri to Escherichia coli K-12. In this placebo-controlled study, four doses of vaccine ranging from 2.3 to 9.0 x 10(8) colony-forming units were given on days 0, 3, 14 and 17. Vaccine shedding occurred from 1 to 3 days after each dose. The vaccine was well tolerated at every dose tested. Significant levels of IgA, IgG or IgM antibody-secreting cells (ASC) recognizing S. flexneri 2a lipopolysaccharide (LPS) were found in 94% of a volunteer subset tested 7 days after the first dose of EcSf2a-2. Seven days after the third dose, ASC were detected less often (57%), and were mainly IgA. Significant rises in serum antibody to LPS were detected in 37% of vaccine recipients. C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DIV COMMUNICABLE DIS & IMMUNOL,WASHINGTON,DC 20307. DEPT PREVENT MED,FT ORD,CA 93941. RP TAYLOR, DN (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT ENTER INFECT,WASHINGTON,DC 20307, USA. NR 15 TC 8 Z9 8 U1 0 U2 0 PU BUTTERWORTH-HEINEMANN LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB SN 0264-410X J9 VACCINE JI Vaccine PD MAY PY 1994 VL 12 IS 6 BP 565 EP 568 DI 10.1016/0264-410X(94)90318-2 PG 4 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA NE606 UT WOS:A1994NE60600016 PM 8036831 ER PT J AU ZINK, MC JOHNSON, LK AF ZINK, MC JOHNSON, LK TI PATHOBIOLOGY OF LENTIVIRUS INFECTIONS OF SHEEP AND GOATS SO VIRUS RESEARCH LA English DT Article; Proceedings Paper CT Symposium on the Comparative Biology of Lentivirus Infections CY JUN 14-15, 1993 CL WASHINGTON, DC SP REGISTRY COMPARAT PATHOL ID CAPRINE ARTHRITIS-ENCEPHALITIS; OVINE PROGRESSIVE PNEUMONIA; VISNA VIRUS; MAEDI-VISNA; MACROPHAGES; EXPRESSION; REPLICATION; IDENTIFICATION; EPIDEMIOLOGY; LYMPHOCYTES C1 USA,INST PATHOL,REGISTRY COMPARAT PATHOL,WASHINGTON,DC 20306. RP ZINK, MC (reprint author), JOHNS HOPKINS UNIV,SCH MED,DIV COMPARAT MED,720 RUTLAND AVE,BALTIMORE,MD 21205, USA. RI Johnson, Linda/B-1828-2014 OI Johnson, Linda/0000-0002-7574-7753 NR 37 TC 27 Z9 28 U1 0 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0168-1702 J9 VIRUS RES JI Virus Res. PD MAY PY 1994 VL 32 IS 2 BP 139 EP 154 DI 10.1016/0168-1702(94)90039-6 PG 16 WC Virology SC Virology GA NL495 UT WOS:A1994NL49500004 PM 8067051 ER PT J AU FULTZ, PN ZACK, PM AF FULTZ, PN ZACK, PM TI UNIQUE LENTIVIRUS HOST INTERACTIONS - SIVSMMPBJ14 INFECTION OF MACAQUES SO VIRUS RESEARCH LA English DT Article; Proceedings Paper CT Symposium on the Comparative Biology of Lentivirus Infections CY JUN 14-15, 1993 CL WASHINGTON, DC SP REGISTRY COMPARAT PATHOL ID SIMIAN IMMUNODEFICIENCY VIRUS; SOOTY MANGABEY MONKEYS; LYMPHOCYTES; PATHOGENICITY; RETROVIRUS; ACTIVATION; VARIANT; SIV/SMM; TROPISM AB The most virulent primate lentivirus identified to date, the simian virus SIVsmmPBj14 (SiV-PBj14), is unique not only because it causes acute disease and death within days instead of months or years, but also because of its replicative and cellular activation properties. The acute disease syndrome has many features in common with primary HIV-1 disease, but differences in the respective outcomes of these two acute lentiviral infections appear to be linked to the rapidity with which SIV-PBj14 replicates and the high titers of virus that subsequently accumulate in lymphoid tissues. The most prominent pathologic feature of SIV-PBj14 is extensive lymphoid hyperplasia of T-cell zones, especially in the gut-associated lymphoid tissue. These expanded T-cell zones contain a high proportion of lymphoblasts, activated macrophages and syncytial cells, which are positively correlated with high numbers of SIV antigen-positive cells. Replication of the virus to high titers, accompanied by extensive cellular activation and proliferation, leading to high levels of cytokines, such as interleukin-6 and tumor necrosis factor-alpha, are consistent with acute inflammatory disease. The pathogenesis of SIV-PBj14 also appears to correlate most directly with some of its unique biologic properties, such as the ability to replicate in resting peripheral blood mononuclear cells, to activate lymphocytes, and to induce lymphocyte proliferation. Biologically and molecularly cloned viruses derived from SIV-PBj14 and isolates obtained from macaque PBj at earlier times, are being used to identify viral determinants that influence biologic and pathogenic properties of SIV-PBj14. Further characterization of this virus should provide new insights into lentivirus-cell interactions and their contributions to disease. C1 WALTER REED ARMY INST RES,DIV RETROVIROL,WASHINGTON,DC 20307. RP FULTZ, PN (reprint author), UNIV ALABAMA,DEPT MICROBIOL,845 19TH ST S,BBRB 511,BIRMINGHAM,AL 35294, USA. FU NIAID NIH HHS [AI27136, AI32377] NR 35 TC 50 Z9 50 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0168-1702 J9 VIRUS RES JI Virus Res. PD MAY PY 1994 VL 32 IS 2 BP 205 EP 225 DI 10.1016/0168-1702(94)90042-6 PG 21 WC Virology SC Virology GA NL495 UT WOS:A1994NL49500007 PM 8067054 ER PT J AU POSNER, GH OH, CH WANG, DS GERENA, L MILHOUS, WK MESHNICK, SR ASAWAMAHASADKA, W AF POSNER, GH OH, CH WANG, DS GERENA, L MILHOUS, WK MESHNICK, SR ASAWAMAHASADKA, W TI MECHANISM-BASED DESIGN, SYNTHESIS, AND IN-VITRO ANTIMALARIAL TESTING OF NEW 4-METHYLATED TRIOXANES STRUCTURALLY RELATED TO ARTEMISININ - THE IMPORTANCE OF A CARBON-CENTERED RADICAL FOR ANTIMALARIAL ACTIVITY SO JOURNAL OF MEDICINAL CHEMISTRY LA English DT Letter ID QINGHAOSU ARTEMISININ; RESISTANT MALARIA; SESQUITERPENE; CONVERSION; METABOLISM; DRUGS; ARTEETHER; INVITRO; ANNUA; ACID C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307. UNIV MICHIGAN,SCH PUBL HLTH,DEPT EPIDEMIOL,ANN ARBOR,MI 48109. RP POSNER, GH (reprint author), JOHNS HOPKINS UNIV,DEPT CHEM,CHARLES & 34TH ST,BALTIMORE,MD 21218, USA. NR 40 TC 156 Z9 162 U1 0 U2 13 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0022-2623 J9 J MED CHEM JI J. Med. Chem. PD APR 29 PY 1994 VL 37 IS 9 BP 1256 EP 1258 DI 10.1021/jm00035a003 PG 3 WC Chemistry, Medicinal SC Pharmacology & Pharmacy GA NJ887 UT WOS:A1994NJ88700003 PM 8176702 ER PT J AU FLEMISH, JR XIE, K ZHAO, JH AF FLEMISH, JR XIE, K ZHAO, JH TI SMOOTH ETCHING OF SINGLE-CRYSTAL 6H-SIC IN AN ELECTRON-CYCLOTRON-RESONANCE PLASMA REACTOR SO APPLIED PHYSICS LETTERS LA English DT Article ID SIC THIN-FILMS; FLUORINATED GASES; MIXTURES; CF4; SF6 AB Single-crystal 6H-SiC has been etched using a CF4/O2 gas mixture in an electron cyclotron resonance (ECR) plasma reactor. ECR etching results in SiC surfaces which are extremely smooth, without the problematic micromasking effects which have been reported to result from reactive ion etching in capacitively coupled radio-frequency plasma reactors. The effects of microwave power, total pressure, substrate temperature, and substrate bias on the etch rate, surface morphology, etch profile, and etch selectivity have been evaluated. The etch rate increases with increasing power and bias, and decreasing pressure. However, high biases lead to enhanced etching in regions adjacent to sidewall features. Improved etch profiles and selectivity are obtained with lower applied substrate bias. C1 RUTGERS STATE UNIV,DEPT ELECT & COMP ENGN,PISCATAWAY,NJ 08855. RP FLEMISH, JR (reprint author), USA,RES LAB,ELECTR & POWER SOURCES DIRECTORATE,FT MONMOUTH,NJ 07703, USA. NR 18 TC 45 Z9 45 U1 0 U2 5 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD APR 25 PY 1994 VL 64 IS 17 BP 2315 EP 2317 DI 10.1063/1.111629 PG 3 WC Physics, Applied SC Physics GA NH390 UT WOS:A1994NH39000043 ER PT J AU KARPAS, Z EICEMAN, GA EWING, RG HARDEN, CS AF KARPAS, Z EICEMAN, GA EWING, RG HARDEN, CS TI COLLISION-INDUCED DISSOCIATION STUDIES OF PROTONATED ALCOHOL AND ALCOHOL-WATER CLUSTERS BY ATMOSPHERIC-PRESSURE IONIZATION TANDEM MASS-SPECTROMETRY .2. ETHANOL, PROPANOL AND BUTANOL SO INTERNATIONAL JOURNAL OF MASS SPECTROMETRY AND ION PROCESSES LA English DT Article DE PROTONATED CLUSTERS; HETEROCLUSTERS; ALCOHOL CLUSTERS; API-MS-MS; CLUSTER ION STRUCTURE ID ELECTRON-IMPACT IONIZATION; MULTIPHOTON IONIZATION; MIXED CLUSTERS; HYDROGEN-IONS; METHANOL; SOLVATION; GAS; MECHANISMS; THERMOCHEMISTRY; HETEROCLUSTERS AB Protonated clusters of alcohols, (ROH)(n)H+, and alcohol-water heteroclusters, (ROH)n(H2O)mH+, where R = C2H5, n-C3H7, iso-C3H7, n-C4H9, iso-C4H9, sec-C4H9 and tert-C4H9, were formed in an atmospheric pressure ionization (API) corona discharge source, through proton transfer and displacement ion-molecule reactions with (H2O)nH+. The cluster ions were then subjected to collision induced dissociation (CID) in a tandem mass spectrometer (API-MS-MS). Stabilities of the clusters were examined through cluster size distribution analysis and CID reaction channels. The results gave insights about the structure and energetics of the clusters. The heteroclusters demonstrated a strong preference for water elimination over alcohol elimination, indicating that the alcohol moiety was the favored protonation site. The CID results indicated that in the heteroclusters water ligands were near the periphery of a chain, along which water and alcohol molecules were hydrogen bonded. This structural model could rationalize product ion formation through a single hydrogen bond cleavage for mild CID conditions and through breaking of two hydrogen bonds or a single bond after proton migration along the chain under enhanced fragmentation conditions. CID of protonated alcohols showed differences in the cleavage of C-O bonds vs. O-H+ bonds, as well as variance in product ion distributions in the alcohols. C1 USA,EDGEWOOD RES DEV & ENGN CTR,ABERDEEN PROVING GROUND,MD 21010. NUCL RES CTR NEGEV,DEPT CHEM,IL-84190 BEER SHEVA,ISRAEL. RP KARPAS, Z (reprint author), NEW MEXICO STATE UNIV,DEPT CHEM,LAS CRUCES,NM 88003, USA. NR 37 TC 13 Z9 13 U1 1 U2 10 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0168-1176 J9 INT J MASS SPECTROM JI Int. J. Mass Spectrom. Ion Process. PD APR 21 PY 1994 VL 133 IS 1 BP 47 EP 58 DI 10.1016/0168-1176(94)03948-8 PG 12 WC Physics, Atomic, Molecular & Chemical; Spectroscopy SC Physics; Spectroscopy GA NL826 UT WOS:A1994NL82600005 ER PT J AU JENKINS, TF MIYARES, PH MYERS, KF MCCORMICK, EF STRONG, AB AF JENKINS, TF MIYARES, PH MYERS, KF MCCORMICK, EF STRONG, AB TI COMPARISON OF SOLID-PHASE EXTRACTION WITH SALTING-OUT SOLVENT-EXTRACTION FOR PRECONCENTRATION OF NITROAROMATIC AND NITRAMINE EXPLOSIVES FROM WATER SO ANALYTICA CHIMICA ACTA LA English DT Article DE LIQUID CHROMATOGRAPHY; EXPLOSIVES; EXTRACTION; GROUND WATER; PRECONCENTRATION; WATERS ID RESIDUES; SOLUTES AB Residues of high explosives are a significant pollution problem at U.S. military facilities. Because TNT, RDX and HMX, as well as several manufacturing impurities and environmental transformation products, are mobile in the soil and have caused groundwater pollution, there is an increasing demand for low-concentration analysis of these compounds in water from installation boundary wells. Because RDX and HMX are polar, conventional liquid-liquid extraction with nonpolar solvents yields poor recovery. Two techniques have been reported that appear to offer improved recovery and adequate preconcentration: solid phase extraction (SPE) and salting-out solvent extraction (SOE). This paper compares resin based cartridge-SPE, membrane-SPE, and SOE using fortified reagent grade water samples and a set of 58 groundwater samples from an explosives-contaminated military facility. The three methods were comparable with respect to low-concentration detection capability, which ranged from 0.05 to 0.30 mu Lg/l. Percent recoveries generally exceeded 80%, except for HMX and RDX by membrane-SPE. Interferences were found in extracts from half of the groundwater samples preconcentrated using the two SPE procedures, but were not found in any of the extracts from the SOE. These interferences were traced to matrix interaction of the polymeric resins with low-pH groundwater containing high levels of dissolved solids. C1 USA,ENGINEER WATERWAYS EXPT STN,VICKSBURG,MS 39180. RP JENKINS, TF (reprint author), USA,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 23 TC 71 Z9 71 U1 4 U2 14 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0003-2670 J9 ANAL CHIM ACTA JI Anal. Chim. Acta PD APR 20 PY 1994 VL 289 IS 1 BP 69 EP 78 DI 10.1016/0003-2670(94)80009-X PG 10 WC Chemistry, Analytical SC Chemistry GA NF412 UT WOS:A1994NF41200009 ER PT J AU TURNEY, C GREENSMITH, M SHIPP, M MORDHORST, C WHITTINGSLOW, C BRAWLEY, L KOPPEL, D BRIDGES, E DAVIS, G VOSS, J LEE, R JAY, M ABBOTT, S BRYANT, R REILLY, K WERNER, SB BARRETT, L JACKSON, RJ RUTHERFORD, GW LIOR, H AF TURNEY, C GREENSMITH, M SHIPP, M MORDHORST, C WHITTINGSLOW, C BRAWLEY, L KOPPEL, D BRIDGES, E DAVIS, G VOSS, J LEE, R JAY, M ABBOTT, S BRYANT, R REILLY, K WERNER, SB BARRETT, L JACKSON, RJ RUTHERFORD, GW LIOR, H TI ESCHERICHIA-COLI O157-H7 OUTBREAK LINKED TO HOME-COOKED HAMBURGER - CALIFORNIA, JULY 1993 (REPRINTED FROM MMWR, VOL 43, PG 213-216) SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Reprint C1 MENDOCINO PUBL HLTH DEPT,FT BRAGG,CA 95437. CALIF DEPT HLTH SERV,SACRAMENTO,CA. HLTH & WELF CANADA,LAB CTR DIS CONTROL,NATL LAB ENTER PATHOGENS,OTTAWA K1A 0L2,ONTARIO,CANADA. RP TURNEY, C (reprint author), MENDOCINO COAST DIST HOSP,DEPT MICROBIOL,FT BRAGG,CA 95437, USA. NR 7 TC 2 Z9 2 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD APR 20 PY 1994 VL 271 IS 15 BP 1153 EP 1154 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA NF207 UT WOS:A1994NF20700008 ER PT J AU BOYLE, T KAZIM, H JETT, M AF BOYLE, T KAZIM, H JETT, M TI STIMULATION OF ARACHIDONATE METABOLISM IN NCI-H209 LUNG-CELLS BY STAPHYLOCOCCAL ENTEROTOXIN-B AND OTHER AGONISTS SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,DIV PATHOL,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR 19 PY 1994 VL 8 IS 7 BP A1472 EP A1472 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA NH516 UT WOS:A1994NH51601453 ER PT J AU JETT, M TRAN, U GEMSKI, P LEE, P BOYLE, T MCKEY, V AF JETT, M TRAN, U GEMSKI, P LEE, P BOYLE, T MCKEY, V TI STAPHYLOCOCCAL ENTEROTOXIN-B ACTIVATES PROTEIN-KINASE-C, PHOSPHOLIPASE-C AND ARACHIDONATE METABOLISM IN HUMAN THROMBOCYTES SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,DIV PATHOL,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR 19 PY 1994 VL 8 IS 7 BP A1464 EP A1464 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA NH516 UT WOS:A1994NH51601409 ER PT J AU MATYAS, GR ALVING, CR AF MATYAS, GR ALVING, CR TI EFFECT OF ROUTE OF ADMINISTRATION ON GENERATION OF DIFFERENT ISOTYPE ANTIBODIES TO LIPOSOME-ENCAPSULATED RICIN SUBUNITS SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,DEPT MEMBRANE BIOCHEM,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR 19 PY 1994 VL 8 IS 7 BP A1464 EP A1464 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA NH516 UT WOS:A1994NH51601405 ER PT J AU NAIR, PP SHAMI, S LOHANI, A SALATA, K AF NAIR, PP SHAMI, S LOHANI, A SALATA, K TI EXFOLIATED COLONIC EPITHELIAL-CELLS EXHIBIT CELLULAR CYTOTOXICITY TOWARDS LS-180 COLON ADENOCARCINOMA CELLS SO FASEB JOURNAL LA English DT Meeting Abstract C1 USDA,BELTSVILLE HUMAN NUTR RES CTR,BELTSVILLE,MD 20705. JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,BALTIMORE,MD 21205. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 1 Z9 1 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR 19 PY 1994 VL 8 IS 7 BP A1453 EP A1453 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA NH516 UT WOS:A1994NH51601342 ER PT J AU PLESS, DD WELLNER, RB AF PLESS, DD WELLNER, RB TI COMPARISON OF IN-VITRO FUSION PROPERTIES OF ENDOCYTIC VESICLES CONTAINING RICIN OR TRANSFERRIN SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,MRIID,DIV TOXICOL,FREDERICK,MD 21702. NR 1 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR 19 PY 1994 VL 8 IS 7 BP A1313 EP A1313 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA NH516 UT WOS:A1994NH51600533 ER PT J AU RAY, R YOURICK, JJ MAJERUS, BJ BOWERSOX, SL ANDERSON, DR AF RAY, R YOURICK, JJ MAJERUS, BJ BOWERSOX, SL ANDERSON, DR TI EFFECT OF LINOLEIC-ACID SUPPLEMENTATION ON SULFUR MUSTARD TOXICITY IN CULTURED NORMAL HUMAN EPIDERMAL-KERATINOCYTES SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010. NR 1 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR 19 PY 1994 VL 8 IS 7 BP A1453 EP A1453 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA NH516 UT WOS:A1994NH51601346 ER PT J AU SAXENA, A DOCTOR, BP AF SAXENA, A DOCTOR, BP TI STRUCTURAL-ANALYSIS OF THE ASPARAGINE-LINKED OLIGOSACCHARIDES OF MAMMALIAN CHOLINESTERASES SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD APR 19 PY 1994 VL 8 IS 7 BP A1426 EP A1426 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA NH516 UT WOS:A1994NH51601191 ER PT J AU DELL, PA KOHLMAN, WG AF DELL, PA KOHLMAN, WG TI EFFECTS OF WATER-CONTENT ON THE PROPERTIES OF STARCH POLY(ETHYLENE VINYL ALCOHOL) BLENDS SO JOURNAL OF APPLIED POLYMER SCIENCE LA English DT Article ID BLOWN FILMS; MOISTURE AB The physical properties of unmodified starch, poly(ethylene vinyl alcohol), glycerol, and water mixtures are reported. Thermal and melt-flow properties of the preprocessed, physically mixed materials were determined along with the tensile properties and morphology of injection-molded microtensile samples. Melt-flow properties were measured by a capillary rheometer, and the water content was varied from 4 to 18%. The morphology, rheology, and tensile properties are all highly related to the percentage of water present. A transition in the tensile properties and morphology of the blends was observed at approximately 11% moisture content. (C) 1994 John Wiley & Sons, Inc. C1 USA,NATICK RES DEV & ENGN CTR,NATICK,MA 01760. RP DELL, PA (reprint author), GEOCENTERS INC,7 WELLS AVE,NEWTON,MA 02159, USA. NR 28 TC 17 Z9 17 U1 0 U2 1 PU JOHN WILEY & SONS INC PI NEW YORK PA 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0021-8995 J9 J APPL POLYM SCI JI J. Appl. Polym. Sci. PD APR 18 PY 1994 VL 52 IS 3 BP 353 EP 363 DI 10.1002/app.1994.070520301 PG 11 WC Polymer Science SC Polymer Science GA NA981 UT WOS:A1994NA98100001 ER PT J AU BYRD, JC WEISS, RB AF BYRD, JC WEISS, RB TI RECURRENT GRANULOCYTIC SARCOMA - AN UNUSUAL VARIATION OF ACUTE MYELOGENOUS LEUKEMIA ASSOCIATED WITH 8-21 CHROMOSOMAL TRANSLOCATION AND BLAST EXPRESSION OF THE NEURAL CELL-ADHESION MOLECULE SO CANCER LA English DT Article DE GRANULOCYTIC SARCOMA; ACUTE MYELOGENOUS LEUKEMIA; NEURAL CELL ADHESION MOLECULE; CHROMOSOMAL TRANSLOCATION; EXTRAMEDULLARY LEUKEMIA ID ACUTE MYELOMONOCYTIC LEUKEMIA; ACUTE MYELOID-LEUKEMIA; CHLOROMA; INVOLVEMENT; CHILDHOOD; TUMORS; NCAM AB This study reports on a patient with acute myelogenous leukemia (AML) in remission who had a series of 11 granulocytic sarcomas (chloromas or myeloblastomas) appearing periodically over a 29-month interval in a variety of anatomic sites without evidence of bone marrow recurrence. This isolated extramedullary recurrence of AML is distinctly unusual with only 24 cases described previously. This patient had the greatest number and longest reported interval of recurrent granulocytic sarcomas (GS) before bone marrow relapse. Furthermore, he represents the first case of a patient with GS presenting with both an 8; 21 chromosomal translocation and neural cell adhesion molecule (CD56) expression. The authors hypothesize that these two abnormalities identified previously as predisposing factors to GS may, in fact, be synergistic for this phenomenon. His case and the review of the literature demonstrate some of the important clinical and management features of a patient who develops GS while in complete marrow remission from previous AML. Although highly sensitive to radiation therapy, the onset of granulocytic sarcomas is almost always followed by bone marrow relapse and should be treated with aggressive reinduction chemotherapy and local irradiation. Such therapy is associated with the longest interval of disease-free survival. C1 WALTER REED ARMY MED CTR,DEPT MED,MED ONCOL SECT,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20014. FU NCI NIH HHS [CA 26806] NR 41 TC 67 Z9 70 U1 0 U2 1 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0008-543X J9 CANCER JI Cancer PD APR 15 PY 1994 VL 73 IS 8 BP 2107 EP 2112 DI 10.1002/1097-0142(19940415)73:8<2107::AID-CNCR2820730815>3.0.CO;2-W PG 6 WC Oncology SC Oncology GA NF160 UT WOS:A1994NF16000014 PM 7512442 ER PT J AU KIANG, JG AF KIANG, JG TI CORTICOTROPIN-RELEASING FACTOR INCREASES [CA2+](I) VIA RECEPTOR-MEDIATED CA2+ CHANNELS IN HUMAN EPIDERMOID A-431 CELLS SO EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION LA English DT Article DE CA2+; CORTICOTROPIN-RELEASING FACTOR; CA2+ CHANNEL; PERTUSSIS TOXIN; EPITHELIUM ID FACTOR (CRF)-LIKE IMMUNOREACTIVITY; CYTOSOLIC FREE CA2+; ADRENOCORTICOTROPIN SECRETION; SIGNAL TRANSDUCTION; PITUITARY-CELLS; THERMAL-INJURY; FREE CALCIUM; RAT PAWSKIN; A431 CELLS; PROTEIN AB Corticotropin-releasing factor (CRF) has been shown to attenuate vascular leakage in injured skin, mucous membrane, muscle, and brain. Calcium is thought to play an important role in many of the physiological responses to CRF, but there has been little characterization of how calcium is involved in process by which CRF protects damaged tissues. The goal of this study was to characterize changes in cytosolic free calcium concentrations ([Ca2+],) in human epidermoid A-431 cells exposed to human/rat-CRF and to investigate the mechanisms by which these changes occur. The resting [Ca2+](i) in normal cells at 37 degrees C was 66 +/- 4 nM (n = 32). When cells were treated with CRF, [Ca2+](i) increased immediately. The increase depended on CRF concentration, with a median effective concentration of 11 pM. This increase in [Ca2+](i) depended on external Ca2+ but not Na+, Mg2+, Or K+ La3+ (10 mu M) and Co2+ (10 mu M) inhibited the CRF-induced [Ca2+](i) increase, whereas verapamil and nifedipine tested at concentrations up to 1 mM did not. alpha-Helical CRF-(9-41), a synthetic CRF receptor antagonist, and pertussis toxin blocked the increase in [Ca2+](i) induced by CRF, which suggests that the entry of extracellular Ca2+ is mediated by receptor-operated Ca2+ channels coupled with pertussis toxin-sensitive G proteins. Although 420 pM CRF stimulated an immediate increase in [Ca2+](i), inositol trisphosphate and cellular cAMP levels did not change within 1 min either in the presence or absence of external Ca2+ U-73122 (an inhibitor of inositol trisphosphate production), amiloride and benzamil (inhibitors of the Na(/)CA(2+) exchanger) also did not block the increase in [Ca2+](i) induced by CRF. CRF also increased [Ca2+](i) in cells treated with TMB-8 or ryanodine, inhibitors of intracellular Ca2+ mobilization. The results suggest that CRF stimulates a Ca2+ influx through CRF receptor-operated Ca2+ channels. RP KIANG, JG (reprint author), WALTER REED ARMY INST RES,DIV MED,DEPT CLIN PHYSIOL,WASHINGTON,DC 20307, USA. NR 39 TC 22 Z9 22 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0922-4106 J9 EUR J PHARM-MOLEC PH JI Eur. J. Pharmacol.-Molec. Pharmacol. Sect. PD APR 15 PY 1994 VL 267 IS 2 BP 135 EP 142 DI 10.1016/0922-4106(94)90164-3 PG 8 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA NH856 UT WOS:A1994NH85600001 PM 8050474 ER PT J AU TAWA, GJ MIELKE, SL TRUHLAR, DG SCHWENKE, DW AF TAWA, GJ MIELKE, SL TRUHLAR, DG SCHWENKE, DW TI ALGEBRAIC VARIATIONAL AND PROPAGATION FORMALISMS FOR QUANTAL DYNAMICS CALCULATIONS OF ELECTRONIC-TO-VIBRATIONAL, ROTATIONAL ENERGY-TRANSFER AND APPLICATION TO THE QUENCHING OF THE 3P STATE OF SODIUM BY HYDROGEN MOLECULES SO JOURNAL OF CHEMICAL PHYSICS LA English DT Article ID INTEGRAL CROSS-SECTIONS; MECHANICAL REACTION PROBABILITIES; CHARGE-TRANSFER PROCESSES; BASIS-SET CALCULATIONS; S-MATRIX VERSION; SCATTERING CALCULATIONS; INELASTIC-COLLISIONS; ADIABATIC REPRESENTATIONS; DIABATIC REPRESENTATION; HYPERSPHERICAL METHOD AB Two approaches, the outgoing wave variational principle (OWVP) and R-matrix propagation (RMProp), are presented for quantum dynamics calculations of inelastic scattering in systems involving two coupled potential energy surfaces (PES). The two formalisms are applied to Na(3p P-2) collisions with H-2 at a total energy of 2.426 eV with zero and unit total angular momentum. This provides a challenging test case because the accessible region of the excited-state potential energy surface intersects the ground-state surface conically and involves H-H internuclear distances that are far larger than their equilibrium values in the ground state. We present the details of the formalisms for treating coupled surfaces, and we present converged results for the quenching probability and final vibrational-rotational quantum state distributions of the quenching agent. Convergence of the transition probabilities is established by convergence checks within each formalism, by obtaining the same results with laboratory-frame and body-frame basis functions in the OWVP formalism, and by obtaining the same results with the OWVP as with RMProp. C1 NASA, AMES RES CTR, MOFFETT FIELD, CA 94035 USA. UNIV MINNESOTA, USA, HIGH PERFORMANCE COMP RES CTR, MINNEAPOLIS, MN 55455 USA. RP TAWA, GJ (reprint author), UNIV MINNESOTA, INST SUPERCOMP, DEPT CHEM, CHEM PHYS PROGRAM, MINNEAPOLIS, MN 55455 USA. RI Mielke, Steven/B-7533-2008; schwenke, david/I-3564-2013; Truhlar, Donald/G-7076-2015 OI Mielke, Steven/0000-0002-1938-7503; Truhlar, Donald/0000-0002-7742-7294 NR 182 TC 57 Z9 57 U1 2 U2 3 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-9606 J9 J CHEM PHYS JI J. Chem. Phys. PD APR 15 PY 1994 VL 100 IS 8 BP 5751 EP 5777 DI 10.1063/1.467140 PG 27 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA NF081 UT WOS:A1994NF08100037 ER PT J AU BURGESS, EB AF BURGESS, EB TI LEAD US NOT INTO PENN-STATION - DUCKER,B SO LIBRARY JOURNAL LA English DT Book Review RP BURGESS, EB (reprint author), USA,TRALINET CTR,FT MONROE,VA 23662, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 SN 0363-0277 J9 LIBR J JI Libr. J. PD APR 15 PY 1994 VL 119 IS 7 BP 111 EP 111 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA NF614 UT WOS:A1994NF61400203 ER PT J AU RUDIN, S REINECKE, TL AF RUDIN, S REINECKE, TL TI INTERACTION OF COUPLED PLASMON-PHONON MODES WITH A POINT-CHARGE IN A POLAR SEMICONDUCTOR SO PHYSICAL REVIEW B LA English DT Article AB The coupled plasmon-longitudinal-optical-phonon modes of a degenerate inhomogeneous electron or hole gas in a bulk compound semiconductor are studied. The interaction of a point charge with these coupled modes is derived in the random-phase approximation for both the carriers and the phonons in a form which is appropriate for treating inhomogeneous carrier systems. An integral equation governing the interaction of a static point charge with these coupled modes is derived which has the same form as that in the case of a point-charge interacting with plasmons alone but in which the parameters are modified by the coupling to phonons. As a specific example, these results are used to study the binding of the coupled plasmon-phonon modes to point charges in degenerate compound semiconductors, and it is found that such bound states will exist only at very low carrier densities. C1 USN, RES LAB, WASHINGTON, DC 20375 USA. RP USA, RES LAB, FT MONMOUTH, NJ 07703 USA. NR 6 TC 1 Z9 1 U1 0 U2 1 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 2469-9950 EI 2469-9969 J9 PHYS REV B JI Phys. Rev. B PD APR 15 PY 1994 VL 49 IS 15 BP 10298 EP 10302 DI 10.1103/PhysRevB.49.10298 PG 5 WC Physics, Condensed Matter SC Physics GA NJ756 UT WOS:A1994NJ75600026 ER PT J AU SOSIN, TP PERLIN, P TRZECIAKOWSKI, W TOBER, R ZARECKA, R AF SOSIN, TP PERLIN, P TRZECIAKOWSKI, W TOBER, R ZARECKA, R TI NEW RESULTS ON OPTICAL PRESSURE SENSORS BASED ON SEMICONDUCTOR QUANTUM-WELLS SO SENSORS AND ACTUATORS A-PHYSICAL LA English DT Article; Proceedings Paper CT Eurosensors VII CY SEP 26-29, 1993 CL BUDAPEST, HUNGARY SP TECH UNIV BUDAPEST, ROLAND EOTVOS PHYS SOC, IMEKO, NATL COMM TECHNOL DEV, INT SCI FDN, COMMISS EUROPEAN COMMUNITIES, DG XII, ELSEVIER SEQUNIA S A AB It is demonstrated that the interband absorption in InGaAs/GaAs quantum wells can be used for accurate pressure calibration up to 5 GPa (at room temperature) and up to 4 GPa at 20 K. By depositing the GaAs or InGaAs quantum-well layers on a thin (20-30 mum) GaAs diaphragm the effects of biaxial deformations on the quantum-well spectra can be studied. This might be useful for the optical characterization of the strain fields in Si diaphragms used as piezoresistive low-pressure sensors. C1 WARSAW UNIV TECHNOL,INST PHYS,PL-00662 WARSAW,POLAND. INST ELECTR MAT TECHNOL,PL-02660 WARSAW,POLAND. USA,COMMAND LAB,ADELPHI,MD 20783. RP SOSIN, TP (reprint author), POLISH ACAD SCI,HIGH PRESSURE RES CTR UNIPRESS,SOKOLOWSKA 29,PL-01142 WARSAW,POLAND. RI Trzeciakowski, Witold/C-4074-2013 NR 6 TC 1 Z9 1 U1 0 U2 1 PU ELSEVIER SCIENCE SA LAUSANNE PI LAUSANNE 1 PA PO BOX 564, 1001 LAUSANNE 1, SWITZERLAND SN 0924-4247 J9 SENSOR ACTUAT A-PHYS JI Sens. Actuator A-Phys. PD APR 15 PY 1994 VL 42 IS 1-3 BP 654 EP 657 DI 10.1016/0924-4247(94)80070-7 PG 4 WC Engineering, Electrical & Electronic; Instruments & Instrumentation SC Engineering; Instruments & Instrumentation GA NM739 UT WOS:A1994NM73900061 ER PT J AU SAMUELSON, LA KAPLAN, DL LIM, JO KAMATH, M MARX, KA TRIPATHY, SK AF SAMUELSON, LA KAPLAN, DL LIM, JO KAMATH, M MARX, KA TRIPATHY, SK TI MOLECULAR RECOGNITION BETWEEN A BIOTINYLATED POLYTHIOPHENE COPOLYMER AND PHYCOERYTHRIN UTILIZING THE BIOTIN STREPTAVIDIN INTERACTION SO THIN SOLID FILMS LA English DT Article ID CONDUCTING POLYMERS; FILMS; PHYCOBILISOMES; MONOLAYERS; SURFACES; CRYSTALS AB The interaction of photoactive proteins with an electroactive matrix is valuable in leading to potential technological applications in opto-electronic signal transduction for optical displays, color mimicking, biosensor, and protein research applications. In this study, the Langmuir-Blodgett technique is used to couple these components through the well-known biotin-streptavidin complexation. Biotinylated copolymers of 3-substituted thiophenes have been synthesized both to enhance mechanical film integrity and to provide the electroactive matrix for attachment of the antennae protein, phycoerythrin. It has been determined that biotinylation of the thiophene copolymers improves their film forming properties and results in stable monolayers. Pressure-area isotherms indicate that protein interaction with the polymer monolayer is occurring with the streptavidin and phycoerythrin proteins. Fluorescence spectroscopy of transferred films confirms the presence of phycoerythrin in the final molecular assemblies. Each stage of protein binding to the biotinylated copolymer monolayer could be monitored through fluorescence microscopy at the air-water interface. These results suggest that this copolymer system is a promising material for integrating virtually any biotinylated macromolecular system to an electroactive matrix. In addition, this copolymer system may be ''fine tuned'' to maximize protein integration by varying the distance between biotin functionalities and/or the length of the biotin spacer arm. C1 UNIV MASSACHUSETTS,DEPT CHEM,CTR ADV MAT,LOWELL,MA 01854. RP SAMUELSON, LA (reprint author), USA,NATICK RES & DEV LABS,CTR DEV & ENGN,DIV BIOTECHNOL,NATICK,MA 01760, USA. NR 39 TC 16 Z9 16 U1 0 U2 3 PU ELSEVIER SCIENCE SA LAUSANNE PI LAUSANNE 1 PA PO BOX 564, 1001 LAUSANNE 1, SWITZERLAND SN 0040-6090 J9 THIN SOLID FILMS JI Thin Solid Films PD APR 15 PY 1994 VL 242 IS 1-2 BP 50 EP 55 DI 10.1016/0040-6090(94)90500-2 PG 6 WC Materials Science, Multidisciplinary; Materials Science, Coatings & Films; Physics, Applied; Physics, Condensed Matter SC Materials Science; Physics GA NJ668 UT WOS:A1994NJ66800011 ER PT J AU PACKARD, WE DOW, JD ROHRER, H PALMOUR, JW CARTER, CH NICOLAIDES, R AF PACKARD, WE DOW, JD ROHRER, H PALMOUR, JW CARTER, CH NICOLAIDES, R TI SCANNING-TUNNELING-MICROSCOPY WITH A LARGE-GAP SEMICONDUCTOR TIP SO EUROPHYSICS LETTERS LA English DT Article ID SI(111)-(7X7); MORPHOLOGY; SURFACES; EMISSION; IMAGES; STATES AB Atomic-resolution images of the Si(111)-(7 x 7) surface are reported for a scanning tunneling microscope with a large-band-gap semiconducting SiC tip. The semiconducting tip allows one to use the forbidden band pp to inhibit some tunneling transitions, and so raises the possibility of new and interesting surface spectroscopies. C1 IBM CORP,DIV RES,ZURICH RES LAB,CH-8803 RUSCHLIKON,SWITZERLAND. CREE RES INC,DURHAM,NC 27713. USA,ARDEC,DOVER,NJ 07801. RP PACKARD, WE (reprint author), ARIZONA STATE UNIV,DEPT PHYS & ASTRON,TEMPE,AZ 85287, USA. NR 28 TC 1 Z9 1 U1 1 U2 1 PU EDITIONS PHYSIQUE PI LES ULIS CEDEX PA Z I DE COURTABOEUF AVE 7 AV DU HOGGAR, BP 112, 91944 LES ULIS CEDEX, FRANCE SN 0295-5075 J9 EUROPHYS LETT JI Europhys. Lett. PD APR 10 PY 1994 VL 26 IS 2 BP 97 EP 102 DI 10.1209/0295-5075/26/2/004 PG 6 WC Physics, Multidisciplinary SC Physics GA NJ075 UT WOS:A1994NJ07500004 ER PT J AU BRIDGES, TS LEVIN, LA CABRERA, D PLAIA, G AF BRIDGES, TS LEVIN, LA CABRERA, D PLAIA, G TI EFFECTS OF SEDIMENT AMENDED WITH SEWAGE, ALGAE, OR HYDROCARBONS ON GROWTH AND REPRODUCTION IN 2 OPPORTUNISTIC POLYCHAETES SO JOURNAL OF EXPERIMENTAL MARINE BIOLOGY AND ECOLOGY LA English DT Article DE CAPITELLA SP-I; LIFE HISTORY; OPPORTUNISTIC; ORGANIC ENRICHMENT; POLLUTION; REPRODUCTIVE OUTPUT; STREBLOSPIO-BENEDICTI ID STREBLOSPIO-BENEDICTI WEBSTER; DEPOSIT-FEEDING POLYCHAETE; CAPITATA TYPE-I; CAPITELLA-CAPITATA; ORGANIC ENRICHMENT; LECITHOTROPHIC DEVELOPMENT; POPULATION-DYNAMICS; NUTRITIONAL-VALUE; FECUNDITY; DETRITUS AB The effects of organic- (sewage and blue-green algae) and hydrocarbon- (no. 2 fuel oil) amended sediments on growth schedules, age and size at maturity, fecundity, and reproductive output were examined for the opportunistic polychaetes Streblospio benedicti Webster and Capitella sp. 1. The two species responded very differently to the amended sediments. For S. benedicti, asymptotic size was reduced and age at first reproduction occurred later in the algae and hydrocarbon treatments compared to the marsh mud only and sewage treatments. Organic- and hydrocarbon-amended sediments did not affect per brood measures of fecundity or C and N investment in S. benedicti. In contrast, Capitella sp. I exhibited strong, positive responses to the organically amended sediments; this was seen in terms of more rapid growth (2 x), younger age at first reproduction (50%), larger asymptotic size (6 x), and higher per brood fecundity and C and N investment (4 x). Reproductive output, a relative measure of reproductive investment, was not directly affected by treatments in either species. For Capitella sp. I in organically enriched settings, the benefits of larger body size appear to include higher per brood fecundity without increasing the relative cost (in terms of reproductive output) of producing a brood of young. The population explosions of Capitella sp. I in response to organic enrichment are the result of earlier reproduction and increased body size and fecundity. Positive population-level responses of S. benedicti to contaminated sediments may be the result of its ability to tolerate conditions that other members of a community do not. C1 N CAROLINA STATE UNIV,DEPT MARINE EARTH & ATMOSPHER SCI,RALEIGH,NC 27695. UNIV CALIF SAN DIEGO,SCRIPPS INST OCEANOG,MARINE LIFE RES GRP,LA JOLLA,CA 92093. RP BRIDGES, TS (reprint author), WES ES F,USAE WATERWAYS EXPT STN,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 62 TC 84 Z9 85 U1 3 U2 11 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-0981 J9 J EXP MAR BIOL ECOL JI J. Exp. Mar. Biol. Ecol. PD APR 8 PY 1994 VL 177 IS 1 BP 99 EP 119 DI 10.1016/0022-0981(94)90146-5 PG 21 WC Ecology; Marine & Freshwater Biology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA NJ117 UT WOS:A1994NJ11700007 ER PT J AU DONOVAN, WH FAMINI, GR AF DONOVAN, WH FAMINI, GR TI CONFORMATIONAL-ANALYSIS OF SULFUR MUSTARD FROM MOLECULAR MECHANICS, SEMIEMPIRICAL, AND AB-INITIO METHODS SO JOURNAL OF PHYSICAL CHEMISTRY LA English DT Article ID VIBRATIONAL INFRARED FREQUENCIES; ABINITIO CALCULATIONS; DERIVATIVES; HYDROLYSIS; SPECTRA; CHLORIDE; SULFIDES AB We report the results: of a comprehensive computational investigation on the energetics of sulfur mustard (S(CH2CH2Cl)(2)) conformations. Molecular mechanics (MM2*, MM3*, AMBER*, and OPLS*), semiempirical (MNDO, AM1, and PM3), and ab initio (HF/3-21G, HF/6-311G**, MP2/6-31G*, and MP2/6-311G**/ /HF/6-311G**) methods were applied to 12 low-energy structures obtained from a Monte Carlo conformational search using force fields contained in MacroModel 3.5a. In general, there is reasonable agreement between molecular mechanics and ab initio for geometrical properties, but significant differences in the energy predictions. There was more scatter from the semiempirical computations, with the AM 1 model most successfully reproducing the ab initio results. The ab initio calculations identify at least three conformations of sulfur mustard lower in energy than the all-anti structure, depending on the level of theory employed. Vibrational infrared spectra were computed for the four lowest energy structures at the HF/6-311G** level and compared to experimental data, producing a better match than obtained from consideration of a single conformer, but at greater computational cost. RP DONOVAN, WH (reprint author), USA,EDGEWOOD RES DEV & ENGN CTR,RTC,SCBRD,BLDG E3160,ABERDEEN PROVING GROUND,MD 21010, USA. NR 38 TC 9 Z9 9 U1 0 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0022-3654 J9 J PHYS CHEM-US JI J. Phys. Chem. PD APR 7 PY 1994 VL 98 IS 14 BP 3669 EP 3674 DI 10.1021/j100065a021 PG 6 WC Chemistry, Physical SC Chemistry GA NF765 UT WOS:A1994NF76500021 ER PT J AU ZIMMERMAN, GC KEELING, JH LOWRY, M MEDINA, J VONHOFF, DD BURRIS, HA AF ZIMMERMAN, GC KEELING, JH LOWRY, M MEDINA, J VONHOFF, DD BURRIS, HA TI PREVENTION OF DOCETAXEL-INDUCED ERYTHRODYSESTHESIA WITH LOCAL HYPOTHERMIA SO JOURNAL OF THE NATIONAL CANCER INSTITUTE LA English DT Letter ID PALMAR-PLANTAR ERYTHRODYSESTHESIA; INDUCED ACRAL ERYTHEMA; CYTARABINE; TAXOTERE; RP-56976; ANALOG; TAXOL C1 CANC THERAPY & RES CTR S TEXAS,SAN ANTONIO,TX. USA,BROOKE ARMY MED CTR,DEPT MED,HEMATOL ONCOL SERV,MED CORPS,FT SAM HOUSTON,TX 78234. UNIV TEXAS,HLTH SCI CTR,SAN ANTONIO,TX 78284. RP ZIMMERMAN, GC (reprint author), USA,BROOKE ARMY MED CTR,DEPT MED,DERMATOL SERV,MED CORPS,FT SAM HOUSTON,TX 78234, USA. NR 14 TC 25 Z9 26 U1 0 U2 0 PU NATL CANCER INSTITUTE PI BETHESDA PA 9030 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0027-8874 J9 J NATL CANCER I JI J. Natl. Cancer Inst. PD APR 6 PY 1994 VL 86 IS 7 BP 557 EP 558 DI 10.1093/jnci/86.7.557 PG 2 WC Oncology SC Oncology GA ND811 UT WOS:A1994ND81100019 PM 7907667 ER PT J AU COWAN, DN BRUNDAGE, JF POMERANTZ, RS AF COWAN, DN BRUNDAGE, JF POMERANTZ, RS TI THE INCIDENCE OF HIV-INFECTION AMONG MEN IN THE UNITED-STATES-ARMY RESERVE COMPONENTS, 1985-1991 SO AIDS LA English DT Article DE HIV; AIDS; INCIDENCE; EPIDEMIOLOGY; DEMOGRAPHY; ETHNICITY; INCOME; GEOGRAPHY; TRENDS ID IMMUNODEFICIENCY-VIRUS SEROPOSITIVITY; YOUNG-ADULTS; AIDS INCIDENCE; MEMBERS; PREVALENCE; EPIDEMIC; TRENDS; SEROCONVERSION; SPREAD AB Objective: To evaluate the incidence of HIV infection among men in the Army Reserve Components (RC) in the United States. Methods: A prospective follow-up evaluating HIV seroconversions among men in the RC. Men who were initially seronegative were followed over time and periodically retested. The duration of follow-up was measured for each individual. Date of seroconversion was estimated to be the mid-point between last negative and first positive test. Demographic characteristics were evaluated for association with seroconversion, and incidence density between 1985 and 1991 was examined. Results: We followed 733 622 RC men for 1988 622 person-years between 1985 and 1991, and identified 534 seroconversions. Demographic correlates of risk included racial/ethnic minorities, age between 20 and 34 years, never having married, residence in an area with a low median income, and residence in metropolitan areas with high incidence of AIDS. Among most of these groups, the incidence density did not change substantially or significantly from the period 1985-1987 to 1991. Conclusions: The patterns of HIV infection are generally similar to those for reported AIDS cases. The incidence density over time is consistent with projections that AIDS incidence will plateau in the United States in the mid- to late-1990s. C1 WALTER REED ARMY INST RES,DIV PREVENT MED,WASHINGTON,DC 20307. RP COWAN, DN (reprint author), SRA TECHNOL INC,8110 GATEHOUSE RD,6TH FLOOR,FALLS CHURCH,VA 22042, USA. NR 31 TC 10 Z9 10 U1 0 U2 0 PU RAPID SCIENCE PUBLISHERS PI LONDON PA 2-6 BOUNDARY ROW, LONDON, ENGLAND SE1 8NH SN 0269-9370 J9 AIDS JI Aids PD APR PY 1994 VL 8 IS 4 BP 505 EP 511 DI 10.1097/00002030-199404000-00014 PG 7 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA NC298 UT WOS:A1994NC29800014 PM 8011255 ER PT J AU MUSSELMAN, LJ KNEPPER, DA AF MUSSELMAN, LJ KNEPPER, DA TI QUILLWORTS OF VIRGINIA SO AMERICAN FERN JOURNAL LA English DT Article ID SOUTHEASTERN UNITED-STATES; NORTHEASTERN NORTH-AMERICA; NATURALLY-OCCURRING HYBRID; ISOETES-ECHINOSPORA; MORPHOLOGY; TAXONOMY; RIPARIA C1 USA,CORPS ENGINEERS,NORFOLK,VA 23510. RP MUSSELMAN, LJ (reprint author), OLD DOMINION UNIV,DEPT BIOL SCI,NORFOLK,VA 23529, USA. NR 37 TC 9 Z9 10 U1 1 U2 2 PU AMER FERN SOC INC PI WASHINGTON PA C/O DAVID B LELLINGER, SMITHSONIAN INST, BOTANY DEPT, WASHINGTON, DC 20560 SN 0002-8444 J9 AM FERN J JI Am. Fern J. PD APR-JUN PY 1994 VL 84 IS 2 BP 48 EP 68 DI 10.2307/1547699 PG 21 WC Plant Sciences SC Plant Sciences GA NM395 UT WOS:A1994NM39500002 ER PT J AU SCHNEIDER, JJ AF SCHNEIDER, JJ TI THE DEVELOPMENT OF MILITARY THOUGHT - THE 19TH-CENTURY - GAT,A SO AMERICAN HISTORICAL REVIEW LA English DT Book Review RP SCHNEIDER, JJ (reprint author), USA,COMMAND & GEN STAFF COLL,FT LEAVENWORTH,KS, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU AMER HISTORICAL REVIEW PI WASHINGTON PA 400 A ST SE, WASHINGTON, DC 20003 SN 0002-8762 J9 AM HIST REV JI Am. Hist. Rev. PD APR PY 1994 VL 99 IS 2 BP 524 EP 524 DI 10.2307/2167303 PG 1 WC History SC History GA NJ047 UT WOS:A1994NJ04700040 ER PT J AU CRANE, CC AF CRANE, CC TI CROSSWINDS - THE AIR-FORCES SETUP IN VIETNAM - TILFORD,EH SO AMERICAN HISTORICAL REVIEW LA English DT Book Review RP CRANE, CC (reprint author), US MIL ACAD,W POINT,NY 10996, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU AMER HISTORICAL REVIEW PI WASHINGTON PA 400 A ST SE, WASHINGTON, DC 20003 SN 0002-8762 J9 AM HIST REV JI Am. Hist. Rev. PD APR PY 1994 VL 99 IS 2 BP 688 EP 689 PG 2 WC History SC History GA NJ047 UT WOS:A1994NJ04700264 ER PT J AU HILL, RB SANDBERG, G GUNN, BA EBERLY, BJ AF HILL, RB SANDBERG, G GUNN, BA EBERLY, BJ TI REPRODUCIBILITY OF 3 IDENTIFICATION SYSTEMS FOR BIOTYPING OF COAGULASE-NEGATIVE STAPHYLOCOCCI SO AMERICAN JOURNAL OF CLINICAL PATHOLOGY LA English DT Article DE BACTERIAL BIOTYPING; MICROBIOLOGY; STAPHYLOCOCCI ID API STAPH-IDENT; SPECIES IDENTIFICATION; CONVENTIONAL METHODS; EPIDERMIDIS AB Three commercial identification systems were evaluated as tools for biotyping coagulase-negative staphylococci. Emphasis was placed on the reproducibility of component tests and not on the ability of these kits to identify these bacteria accurately. Forty-seven clinical and reference strains of Staphylococcus were tested in duplicate with each system. The Staph-Ident(TM) profile of test results changed for 20 strains on repeat testing, the Staph-Trac(TM) profile changed for 10 strains, and the Vitek GPI(TM) profile changed for 14 strains. The component tests of each system that were responsible for these profile changes were identified. RP HILL, RB (reprint author), TRIPLER ARMY MED CTR,DEPT PATHOL,HONOLULU,HI 96859, USA. NR 17 TC 2 Z9 2 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0002-9173 J9 AM J CLIN PATHOL JI Am. J. Clin. Pathol. PD APR PY 1994 VL 101 IS 4 BP 443 EP 445 PG 3 WC Pathology SC Pathology GA NE911 UT WOS:A1994NE91100008 PM 8160634 ER PT J AU SUSTER, S MORAN, CA BLANCO, M AF SUSTER, S MORAN, CA BLANCO, M TI MYCOBACTERIAL SPINDLE-CELL PSEUDOTUMOR OF THE SPLEEN SO AMERICAN JOURNAL OF CLINICAL PATHOLOGY LA English DT Note DE ACQUIRED IMMUNODEFICIENCY SYNDROME; ATYPICAL MYCOBACTERIA; SPINDLE-CELL PSEUDOTUMOR ID ACQUIRED-IMMUNODEFICIENCY-SYNDROME; INFLAMMATORY PSEUDOTUMOR; AVIUM-INTRACELLULARE; FEATURES; NEOPLASM; AIDS AB A case of spindle-cell pseudotumor of the spleen due to nontuberculous mycobacteria in a patient with acquired immunodeficiency syndrome (AIDS) is described. The patient was a 55-year-old, human immunodeficiency virus-positive Haitian man who died of acute neurologic complications while on treatment for central nervous system toxoplasmosis. At autopsy, an enlarged multinodular spleen was noted. Histologic examination revealed coarse nodules of splenic parenchyma replaced by a dense spindle cell proliferation, admired with scattered inflammatory cells. Immunostains showed strong cytoplasmic positivity of the spindle cells with MAC 387, HAM 56, and alpha-1-antichymotrypsin antibodies and negative staining for actin, vimentin, and S-100 protein antibodies. Ziehl-Neelsen stains revealed numerous elongated acid-fast bacilli within the cytoplasm of the cells that were occasionally lying free within the interstitium. The organisms also had a strongly positive reaction with antibodies to desmin intermediate filaments. Mycobacterial spindle-cell pseudotumor should be included in the differential diagnosis of conditions affecting the spleen in patients with AIDS. C1 MT SINAI MED CTR,ARKADI M RYWLIN DEPT PATHOL & LAB MED,MIAMI,FL. UNIV MIAMI,SCH MED,MIAMI,FL 33152. USA,INST PATHOL,WASHINGTON,DC 20310. PRINCESS MARGARET HOSP,DEPT PATHOL,NASSAU,BAHAMAS. NR 18 TC 33 Z9 34 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0002-9173 J9 AM J CLIN PATHOL JI Am. J. Clin. Pathol. PD APR PY 1994 VL 101 IS 4 BP 539 EP 542 PG 4 WC Pathology SC Pathology GA NE911 UT WOS:A1994NE91100027 PM 8160649 ER PT J AU REID, T ALVING, BM AF REID, T ALVING, BM TI HIRULOG(R) THERAPY FOR HEPARIN-ASSOCIATED THROMBOCYTOPENIA AND DEEP VENOUS THROMBOSIS SO AMERICAN JOURNAL OF HEMATOLOGY LA English DT Letter ID HIRUDIN RP REID, T (reprint author), WALTER REED ARMY INST RES,DEPT HEMATOL,DIV MED,COAGULAT LAB,WASHINGTON,DC, USA. NR 5 TC 4 Z9 4 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0361-8609 J9 AM J HEMATOL JI Am. J. Hematol. PD APR PY 1994 VL 45 IS 4 BP 352 EP 353 DI 10.1002/ajh.2830450423 PG 2 WC Hematology SC Hematology GA MY225 UT WOS:A1994MY22500022 PM 8192819 ER PT J AU TANAKA, S SAGAWA, S MIKI, K CLAYBAUGH, JR SHIRAKI, K AF TANAKA, S SAGAWA, S MIKI, K CLAYBAUGH, JR SHIRAKI, K TI CHANGES IN MUSCLE SYMPATHETIC-NERVE ACTIVITY AND RENAL-FUNCTION DURING POSITIVE-PRESSURE BREATHING IN HUMANS SO AMERICAN JOURNAL OF PHYSIOLOGY LA English DT Article DE PERONEAL MUSCLE NERVE; URINE FLOW; OSMOLAL EXCRETION; CARDIAC OUTPUT; NOREPINEPHRINE; ARGININE VASOPRESSIN; ATRIAL NATRIURETIC PEPTIDES ID MECHANICAL VENTILATION; ARGININE VASOPRESSIN; NEGATIVE-PRESSURE; WATER IMMERSION; PLASMA-RENIN; ADH RELEASE; RESPONSES; SYSTEM; CATECHOLAMINES; RECEPTORS AB The possibility that the decreased urinary flow during continuous positive-pressure breathing (CPPB) may be a consequence of a reflex mediated via the cardiopulmonary baroreceptors to increase neurohumoral secretion or to change the sympathetic outflow was assessed. Muscle sympathetic nerve activity (MSNA) on the right peroneal nerve, vasoactive hormones, and renal and cardiovascular responses were measured during CPPB (+12 mmHg) in 10 male subjects (22.0 +/- 0.6 yr, 66.8 +/- 1.5 kg body wt). The experiments consisted of a 1-h control, 1 h with CPPB (experimental) or without CPPB (a time control), and a 1-h recovery period. Two blood samples were taken during each period for measurements of arginine vasopressin (AVP), plasma aldosterone (P-Aldo), plasma renin activity (PRA), norepinephrine, and atrial natriuretic peptide (ANP), and urine was collected hourly for the measurement of urine volume and electrolytes and clearances. MSNA rapidly increased (P < 0.05) at the onset of CPPB, continued to increase during exposure, and rapidly returned to the normal level at recovery. The MSNA changes coincided with increased plasma NE and were concurrent with a reduced (P < 0.05) urine output associated with a reduction of both free water and osmolal clearances, Na+ and osmolal excretions, and creatinine clearance (glomerular filtration rate). AVP and PRA increased(P < 0.05), whereas P-Aldo and ANP were unchanged. The results are consistent with the concept that increased sympathetic outflow may play a role in the reduction of urinary output and Na+ excretion during unloading of the cardiopulmonary receptors. C1 UNIV OCCUPAT & ENVIRONM HLTH,SCH MED,DEPT PHYSIOL,YAHATANISHI KU,KITAKYUSHU 807,FUKUOKA,JAPAN. UNIV OCCUPAT & ENVIRONM HLTH,DEPT REHABIL MED,KITAKYUSHU 807,FUKUOKA,JAPAN. TRIPLER ARMY MED CTR,DEPT CLIN INVEST,HONOLULU,HI 96859. NR 37 TC 23 Z9 24 U1 0 U2 1 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0002-9513 J9 AM J PHYSIOL JI Am. J. Physiol. PD APR PY 1994 VL 266 IS 4 BP R1220 EP R1228 PN 2 PG 9 WC Physiology SC Physiology GA NJ996 UT WOS:A1994NJ99600071 ER PT J AU MORALES, CF ANZUETO, A ANDRADE, F BRASSARD, J LEVINE, SM MAXWELL, LC LAWRENCE, RA JENKINSON, SG AF MORALES, CF ANZUETO, A ANDRADE, F BRASSARD, J LEVINE, SM MAXWELL, LC LAWRENCE, RA JENKINSON, SG TI BUTHIONINE SULFOXIMINE TREATMENT IMPAIRS RAT DIAPHRAGM FUNCTION SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE LA English DT Article ID EXHAUSTIVE EXERCISE; RESPIRATORY MUSCLES; SKELETAL-MUSCLE; BLOOD-FLOW; GLUTATHIONE; METABOLISM; PERFORMANCE; CYCLE AB Activation of the glutathione (GSH) redox cycle with production of glutathione disulfide (GSSG) has been shown to occur in the diaphragm during inspiratory resistive loading (RB). Buthionine sulfoximine (BSO) lowers tissue GSH by irreversibly inhibiting the rate-limiting synthesis enzyme gamma-glutamylcysteine synthetase. We investigated the effects of BSO on rat diaphragm function both at rest and after a period of RB. Rats in the RB groups underwent inspiratory RB until they were unable to sustain 70% of their maximal airway pressure. A portion of the diaphragm was analyzed for GSH and GSSG levels, and measurements of in vitro contractile properties included contraction times, maximal tetanic tension (Po), maximal twitch tension (Pt), and force frequency curves. BSO treatment produced a profound depletion of diaphragmatic GSH. Neither BSO nor RB alone significantly altered diaphragm contractile properties at this load of RB. But, in BSO-RB rats, there was a significant decrease in Pt, Po, and tetanic tension at all frequencies of stimulation compared with those in other groups. These data reveal that animals treated with BSO followed by inspiratory resistive loading exhibit marked diaphragm impairment, suggesting that GSH may play an important role in protecting the diaphragm from the stress induced by this resistive breathing protocol. C1 WILFORD HALL USAF MED CTR,SAN ANTONIO,TX. BROOKE ARMY MED CTR,SAN ANTONIO,TX. AUDIE L MURPHY VET AFFAIR HOSP,SAN ANTONIO,TX. RI Andrade, Francisco/F-1258-2011 OI Andrade, Francisco/0000-0002-2460-5798 FU NHLBI NIH HHS [HL-32824] NR 33 TC 9 Z9 9 U1 0 U2 1 PU AMER LUNG ASSOC PI NEW YORK PA 1740 BROADWAY, NEW YORK, NY 10019 SN 1073-449X J9 AM J RESP CRIT CARE JI Am. J. Respir. Crit. Care Med. PD APR PY 1994 VL 149 IS 4 BP 915 EP 919 PG 5 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA NP836 UT WOS:A1994NP83600012 PM 7908245 ER PT J AU BAUMGARTEN, RK AF BAUMGARTEN, RK TI SPINAL-ANESTHESIA AND POSTOPERATIVE URINARY RETENTION IN PATIENTS WITH BENIGN ANORECTAL DISEASE SO AMERICAN JOURNAL OF SURGERY LA English DT Letter RP BAUMGARTEN, RK (reprint author), USA,MED CORPS,ANESTHESIA SERV,DEPT SURG,WASHINGTON,DC 20310, USA. NR 4 TC 2 Z9 2 U1 0 U2 0 PU CAHNERS PUBL CO PI NEW YORK PA 249 WEST 17 STREET, NEW YORK, NY 10011 SN 0002-9610 J9 AM J SURG JI Am. J. Surg. PD APR PY 1994 VL 167 IS 4 BP 457 EP 457 DI 10.1016/0002-9610(94)90162-7 PG 1 WC Surgery SC Surgery GA NJ999 UT WOS:A1994NJ99900022 PM 8179095 ER PT J AU TURELL, MJ ROMOSER, WS AF TURELL, MJ ROMOSER, WS TI EFFECT OF THE DEVELOPMENTAL STAGE AT INFECTION ON THE ABILITY OF ADULT ANOPHELES-STEPHENSI TO TRANSMIT RIFT-VALLEY FEVER VIRUS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID CULEX-PIPIENS; EQUINE ENCEPHALOMYELITIS; CULICIDAE; DIPTERA; MORTALITY; MOSQUITOS; INGESTION; LARVAE AB The ability of adult Anopheles stephensi to transmit Rift Valley fever virus was determined for mosquitoes inoculated at selected times during development. None of 109 female An. stephensi inoculated as adults transmitted virus to hamsters. In contrast, 83% (50 of 60) of those inoculated as larvae transmitted virus by bite to hamsters. Transmission rates decreased as the stage of the mosquito at the time of inoculation changed from larva to pupa to adult. Transmission rates for adult mosquitoes inoculated as larvae, as pupae < 4 hr after pupation, as pupae > 24 hr after pupation, or as adults were 83%, 25%, 11%, and 0%, respectively. Viral titers recovered from mosquitoes were similar for all groups tested, regardless of stage at infection (larva, pupa, or adult) or of transmission status (transmitter or nontransmitter). Thus, differences in transmission rates may have been due to site-specific (i.e., salivary gland) replication, rather than a generalized increase in viral replication in mosquitoes inoculated at an earlier age. C1 OHIO UNIV,INST TROP & GEOG DIS,DEPT BIOL SCI,ATHENS,OH. RP TURELL, MJ (reprint author), USA,MED RES INST INFECT DIS,DEPT EPIDEMIOL,DIV APPL RES,FT DETRICK,FREDERICK,MD 21702, USA. NR 11 TC 5 Z9 5 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD APR PY 1994 VL 50 IS 4 BP 448 EP 451 PG 4 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA NK485 UT WOS:A1994NK48500008 PM 8166351 ER PT J AU TESH, RB JAHRLING, PB SALAS, R SHOPE, RE AF TESH, RB JAHRLING, PB SALAS, R SHOPE, RE TI DESCRIPTION OF GUANARITO VIRUS (ARENAVIRIDAE, ARENAVIRUS), THE ETIOLOGIC AGENT OF VENEZUELAN HEMORRHAGIC-FEVER SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID LASSA FEVER; EPIDEMIOLOGY AB This paper characterizes Guanarito virus, the etiologic agent of Venezuelan hemorrhagic fever. Based on its morphology and antigenic properties, Guanarito virus appears to be a new member of the Tacaribe complex of the genus Arenavirus, family Arenaviridae. Complement fixation and indirect fluorescent antibody tests showed that Guanarito virus and its antiserum are broadly cross-reactive with other members of the Tacaribe complex, but it can be differentiated from other members of the complex by neutralization test. Guanarito virus causes mortality in suckling mice and adult guinea pigs, but not in adult mice. Inoculated rhesus monkeys developed viremia and became ill; however, they subsequently recovered and responded with production of antibody. To date, all isolates of Guanarito virus have come from sick persons or wild rodents living within a single geographic focus in the central plains of Venezuela. C1 USA,MED RES INST INFECT DIS,DIV DIS ASSESSMENT,FREDERICK,MD 21701. MINIST HLTH & SOCIAL ASSISTANCE,NATL INST HYG RAFAEL RANGEL,CARACAS,VENEZUELA. RP TESH, RB (reprint author), YALE UNIV,SCH MED,DEPT EPIDEMIOL & PUBL HLTH,YALE ARBOVIRUS RES UNIT,POB 208034,NEW HAVEN,CT 06520, USA. FU NIAID NIH HHS [AI-33983, AI-10984] NR 16 TC 54 Z9 57 U1 0 U2 4 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD APR PY 1994 VL 50 IS 4 BP 452 EP 459 PG 8 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA NK485 UT WOS:A1994NK48500009 PM 8166352 ER PT J AU SUWANABUN, N SATTABONGKOT, J WIRTZ, RA ROSENBERG, R AF SUWANABUN, N SATTABONGKOT, J WIRTZ, RA ROSENBERG, R TI THE EPIDEMIOLOGY OF PLASMODIUM-VIVAX CIRCUMSPOROZOITE PROTEIN POLYMORPHS IN THAILAND SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID IMMUNODOMINANT EPITOPE; SPOROZOITES; FALCIPARUM AB Enzyme-linked immunosorbent assays (ELISAs) highly specific for the characteristic repeat units of the circumsporozoite proteins of the VK 247 and VK 210 polymorphs of Plasmodium vivax were used to test sporozoites produced by feeding mosquitoes on 1,711 human volunteers presenting at four locations in Thailand over five years. There was no evidence for the existence of any polymorph other than the two already described. Based on the ELISAs, the overall prevalence of the VK 247 type was 29.5%, including those found mixed with VK 210. Relative proportions of VK 210 and VK 247 differed between collection sites. At all places, the ratio of VK 210 to VK 247 was significantly higher at the end of the nontransmission season than it was later during the annual monsoon, suggesting that there may be intrinsic biological differences between the polymorphs that affect their survival. C1 WALTER REED ARMY INST RES,DEPT ENTOMOL,WASHINGTON,DC 20307. USA MED COMPONENT,DEPT ENTOMOL,BANGKOK,THAILAND. NR 19 TC 14 Z9 15 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD APR PY 1994 VL 50 IS 4 BP 460 EP 464 PG 5 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA NK485 UT WOS:A1994NK48500010 PM 8166353 ER PT J AU UDOMSANGPETCH, R TROYEBLOMBERG, M BROWN, AE THAITHONG, S PERLMANN, P WEBSTER, HK AF UDOMSANGPETCH, R TROYEBLOMBERG, M BROWN, AE THAITHONG, S PERLMANN, P WEBSTER, HK TI LYMPHOCYTE-RESPONSES TO PLASMODIUM-FALCIPARUM RING-INFECTED ERYTHROCYTE SURFACE-ANTIGEN (PF155/RESA) PEPTIDES IN INDIVIDUALS WITH NATURALLY ACQUIRED PLASMODIUM-FALCIPARUM MALARIA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID MEDIATED IMMUNE-RESPONSES; HUMAN T-CELLS; PF155 RESA; SYNTHETIC PEPTIDES; ANTIBODIES; VACCINE; CANDIDATE; EPITOPES; SEQUENCES; REGIONS AB Antibody titers and lymphocyte responses to synthetic peptides corresponding to repeated amino acid sequences of the 3' and 5' regions of Pf155/ring-infected erythrocyte surface antigen (RESA) were studied in two groups of Thai subjects, soldiers (Rangers), and villagers who differed in their history of malaria exposure. The frequency of Pf155/RESA seropositivity was similar in the two groups while the frequency of high titer antibody was significantly greater in villagers than in Rangers. Lymphocyte responsiveness in vitro to all Pf155/RESA peptides was infrequent for both groups although half of the subjects studied responded to crude Plasmodium falciparum asexual blood stage malaria antigen (MA). Among responders, Pf155/RESA peptides elicited lymphocyte responses in which proliferation and interferon-gamma (IFN-gamma) production were not associated, whereas with MA, the two responses were associated. The MA-stimulated lymphocyte proliferation and IFN-gamma production for both groups of volunteers appeared to be independent of antibody titer. In this study, antibody, but not lymphocyte, responses to Pf155/RESA peptides were shown to reflect differences in prior exposure and levels of acquired immunity to falciparum malaria. C1 UNIV STOCKHOLM,DEPT IMMUNOL,S-10691 STOCKHOLM,SWEDEN. ARMED FORCES RES INST MED SCI,USA MED COMPONENT,DEPT IMMUNOL & BIOCHEM,BANGKOK,THAILAND. WHO,COLLABORATING CTR BIOL CHARACTERIZAT MALARIA,BANGKOK,THAILAND. CHULALONGKORN UNIV,FAC SCI,DEPT BIOL,BANGKOK,THAILAND. RP UDOMSANGPETCH, R (reprint author), MAHIDOL UNIV,FAC SCI,DEPT PATHOBIOL,RAMA VI RD,BANGKOK 10400,THAILAND. RI Troye-Blomberg, Marita/B-9210-2016 OI Troye-Blomberg, Marita/0000-0002-2804-0325 NR 29 TC 5 Z9 5 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD APR PY 1994 VL 50 IS 4 BP 465 EP 471 PG 7 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA NK485 UT WOS:A1994NK48500011 PM 8166354 ER PT J AU ECKELS, KH DUBOIS, DR SUMMERS, PL SCHLESINGER, JJ SHELLY, M COHEN, S ZHANG, YM LAI, CJ KURANE, I ROTHMAN, A HASTY, S HOWARD, B AF ECKELS, KH DUBOIS, DR SUMMERS, PL SCHLESINGER, JJ SHELLY, M COHEN, S ZHANG, YM LAI, CJ KURANE, I ROTHMAN, A HASTY, S HOWARD, B TI IMMUNIZATION OF MONKEYS WITH BACULOVIRUS-DENGUE TYPE-4 RECOMBINANTS CONTAINING ENVELOPE AND NONSTRUCTURAL PROTEINS - EVIDENCE OF PRIMING AND PARTIAL PROTECTION SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID MONOCLONAL-ANTIBODIES; RHESUS-MONKEYS; YELLOW-FEVER; VIRUS; MICE; ENCEPHALITIS; VIRULENCE; VACCINE; NS1 AB Groups of rhesus monkeys were immunized with baculovirus-dengue type-4 (DEN-4) recombinant-infected cell extracts. One recombinant contained all of the DEN-4 structural proteins and two nonstructural (NS) proteins (C-M-E-NS1-NS2a), while the other was a fusion protein containing a portion of the respiratory syncytial virus G glycoprotein and DEN-4 envelope glycoprotein (RSVG-E). Both preparations were immunogenic; all monkeys receiving either immunogen responded with the production of antivirion antibodies in enzyme immunoassays. All except one monkey receiving the recombinant b(C-M-E-NS1-NS2a) made antibodies to NS1. One monkey that received b(RSVG-E) showed the production of low levels of neutralizing antibodies. Following challenge with unmodified DEN-4 virus, seven of nine monkeys in the immunized group became infected and were viremic for a mean of 4.1 days. The control, sham-inoculated monkeys were also viremic; the mean number of days of viremia in this group was 4.7 days. The remaining monkeys in the immunized group (n = 7), although not protected, had evidence of priming. Hemagglutination inhibition antibody responses following challenge indicated an anamnestic response in this group of animals. Based on these results, it was concluded that future immunization schedules should be altered to optimize immune responses and that immunization with more potent and purified immunogens would probably result in higher seroconversion rates and antibody levels in monkeys. C1 UNIV ROCHESTER,SCH MED,ROCHESTER,NY 14621. INST BIOL RES,REHOVOT,ISRAEL. NIAID,BETHESDA,MD 20892. UNIV MASSACHUSETTS,SCH MED,DEPT MED,WORCESTER,MA 01655. USA,INFECT DIS RES INST,FREDERICK,MD. RP ECKELS, KH (reprint author), WALTER REED ARMY INST RES,DEPT BIOL RES,WASHINGTON,DC 20307, USA. NR 16 TC 33 Z9 36 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD APR PY 1994 VL 50 IS 4 BP 472 EP 478 PG 7 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA NK485 UT WOS:A1994NK48500012 PM 8166355 ER PT J AU DUNN, MA CHEEVER, AW PAGLIA, LM KELLY, EP DUVALL, RH ANDRADE, ZA GOLDNER, FH AF DUNN, MA CHEEVER, AW PAGLIA, LM KELLY, EP DUVALL, RH ANDRADE, ZA GOLDNER, FH TI REVERSAL OF ADVANCED LIVER FIBROSIS IN RABBITS WITH SCHISTOSOMIASIS-JAPONICA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID MURINE SCHISTOSOMIASIS; HEPATIC-FIBROSIS; COLLAGEN-SYNTHESIS; PRAZIQUANTEL; MANSONI AB Advanced liver fibrosis is generally considered to be irreversible. We studied the reversibility of marked liver fibrosis in rabbits infected with Schistosoma japonicum. We determined liver collagen content, collagen biosynthesis, and collagenase activity using serial biopsy specimens obtained 20, 40, and 60 weeks after infection. Reversibility of this process was investigated in rabbits cured of infection at 21 weeks; control rabbits not cured of infection were also studied. At 20 weeks, liver collagen content was 16-fold greater than normal, with accumulation of collagen types I, III, and V. Synthesis of collagen within fibrotic liver slices was 10-fold greater than normal. Liver collagenolytic activity for a type I substrate was 19-fold greater than normal. After parasitologic cure, a striking morphologic reversal of fibrosis occurred during the subsequent 40 weeks, with the return of liver collagen content to three-fold greater than normal and a 75% decrease in synthetic rates compared with those at 20 weeks (P < 0.01). Collagenolytic activity remained elevated to the same degree noted at 20 weeks. A similar but lesser resolution of fibrosis also occurred in untreated control rabbits, coincident with a spontaneous decrease in new egg deposition known to occur in this model system. We conclude that advanced liver fibrosis in S. japonicum-infected rabbits is slowly reversible after cure or senescence of the infection. A possible mechanism for this reversal is persistently increased collagenolysis as collagen synthesis diminishes. C1 NIAID,PARASIT DIS LAB,BETHESDA,MD 20892. BAYNE JONES ARMY COMMUNITY HOSP,FT POLK,LA 71459. WALTER REED ARMY INST RES,DEPT GASTROENTEROL,DIV MED,WASHINGTON,DC 20307. ALBERT EINSTEIN COLL MED,DEPT BIOCHEM,BRONX,NY 10461. UNIFORMED SERV UNIV HLTH SCI,DEPT MED,DIV DIGEST DIS,BETHESDA,MD 20852. GONCALO MONIZ RES CTR,DEPT PATHOL,BR-41945 SALVADOR,BA,BRAZIL. NR 26 TC 14 Z9 15 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD APR PY 1994 VL 50 IS 4 BP 499 EP 505 PG 7 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA NK485 UT WOS:A1994NK48500015 PM 8166357 ER PT J AU POSNER, GH OH, CH WEBSTER, HK AGER, AL ROSSAN, RN AF POSNER, GH OH, CH WEBSTER, HK AGER, AL ROSSAN, RN TI NEW, ANTIMALARIAL, TRICYCLIC 1,2,4-TRIOXANES - EVALUATIONS IN MICE AND MONKEYS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID ARTEMISININ; MALARIA; DRUG; RESISTANCE; FALCIPARUM; QINGHAOSU AB We have concluded initial preclinical studies with synthetic trioxanes numbered 3-9 and have compared them with artemisinin (numbered 1) using CD-1 mice infected with Plasmodium berghei. Based on their antimalarial effectiveness in mice, two of these synthetic trioxanes were selected for evaluation in Aotus monkeys infected with multidrug-resistant (MDR) P. falciparum. Trioxane numbered 8 (12 and 48 mg/kg), trioxane numbered 9 (12 and 48 mg/kg) and arteether (numbered 2, 48 mg/kg) were administered intramuscularly in three 12-hr doses to A. lemurinus lemurinus (Panamanian owl monkeys) infected with the Vietnam Smith/RE strain of P. falciparum and monitored for parasitemia. Trioxane numbered 8 at 12 mg/kg cleared parasitemia in two monkeys, but recrudescence occurred in one animal. Treatment of the recrudescent infection with 48 mg/kg was curative. Infections in two monkeys treated initially with 48 mg/kg were cured (six-month follow-up). Trioxane numbered 9 produced a similar outcome: 12 mg/kg suppressed parasitemia in two monkeys but was nut curative; however, 48 mg/kg cured infections in all four monkeys treated. These preliminary observations show synthetic trioxanes numbered 8 and 9 to be as effective as arteether (numbered 2) against MDR in P. falciparum in the Aotus monkey. C1 INJE UNIV,DEPT CHEM,KIMHAE 621749,SOUTH KOREA. UNIV MIAMI,SCH MED,CTR TROP PARASIT DIS,DEPT MICROBIOL & IMMUNOL,MIAMI,FL 33177. GORGAS MEM LAB,PANAMA CITY,PANAMA. WALTER REED ARMY INST RES,DIV EXPTL THERAPEUT,WASHINGTON,DC. RP POSNER, GH (reprint author), JOHNS HOPKINS UNIV,DEPT CHEM,BALTIMORE,MD 21218, USA. NR 19 TC 34 Z9 34 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD APR PY 1994 VL 50 IS 4 BP 522 EP 526 PG 5 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA NK485 UT WOS:A1994NK48500018 PM 8166360 ER PT J AU KILLICKKENDRICK, R TANG, Y KILLICKKENDRICK, M JOHNSON, RN NGUMBI, PM SANG, DK LAWYER, PG AF KILLICKKENDRICK, R TANG, Y KILLICKKENDRICK, M JOHNSON, RN NGUMBI, PM SANG, DK LAWYER, PG TI PHLEBOTOMINE SANDFLIES OF KENYA (DIPTERA, PSYCHODIDAE) .3. THE IDENTIFICATION AND DISTRIBUTION OF SPECIES OF THE SUBGENUS LARROUSSIUS SO ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY LA English DT Article ID CUTANEOUS LEISHMANIASIS; VISCERAL LEISHMANIASIS; SOUTHERN SUDAN; VECTORS; DIFFERENTIATION; TROPICA C1 KENYA GOVT MED RES CTR,NAIROBI,KENYA. DIV VECTOR BORNE DIS,NAIROBI,KENYA. WALTER REED ARMY INST RES,DEPT ENTOMOL,WASHINGTON,DC 20307. RP KILLICKKENDRICK, R (reprint author), UNIV LONDON IMPERIAL COLL SCI & TECHNOL,DEPT BIOL,SILWOOD PK,ASCOT SL5 7PY,BERKS,ENGLAND. NR 41 TC 12 Z9 12 U1 0 U2 1 PU CARFAX PUBL CO PI ABINGDON PA PO BOX 25, ABINGDON, OXFORDSHIRE, ENGLAND OX14 3UE SN 0003-4983 J9 ANN TROP MED PARASIT JI Ann. Trop. Med. Parasitol. PD APR PY 1994 VL 88 IS 2 BP 183 EP 196 PG 14 WC Public, Environmental & Occupational Health; Parasitology; Tropical Medicine SC Public, Environmental & Occupational Health; Parasitology; Tropical Medicine GA NT746 UT WOS:A1994NT74600010 PM 8067814 ER PT J AU BROWN, TD OROURKE, TJ KUHN, JG CRAIG, JB HAVLIN, K BURRIS, HA CAGNOLA, J HAMILTON, JM GRINDEY, GB SATTERLEE, WG VONHOFF, DD AF BROWN, TD OROURKE, TJ KUHN, JG CRAIG, JB HAVLIN, K BURRIS, HA CAGNOLA, J HAMILTON, JM GRINDEY, GB SATTERLEE, WG VONHOFF, DD TI PHASE-I TRIAL OF SULOFENUR (LY186641) GIVEN ORALLY ON A DAILY X 21 SCHEDULE SO ANTI-CANCER DRUGS LA English DT Article DE SULOFENUR; PHASE I; SULFONYLUREA; METHEMOGLOBINEMIA; HEMOLYSIS; PHARMACOLOGY ID DIARYLSULFONYLUREAS; AGENT AB Sulofenur (LY186641), a diarylsulfonylurea, was evaluated clinically utilizing either a daily x 21 schedule or a daily x 5 (with 2 days off) for 3 weeks schedule. Eighteen patients with refractory solid tumors received 47 evaluable courses of sulofenur given p.o. daily x 21 every 28 days at five dose levels while 14 received 29 courses of sulofenur given daily x 5 for 3 weeks every 28 days at three dose levels. Toxicities included anemia, methemoglobinemia and hemolysis. One patient experienced a fatal subendocardial infarction on the daily x 21 schedule. One partial response was observed in a patient with a sertoli cell tumor on the daily x 5 for 3 weeks schedule. Daily x 5 for 3 weeks is the schedule recommended for phase II trials. C1 UNIV TEXAS,HLTH SCI CTR,SAN ANTONIO,TX 78284. DUKE UNIV,MED CTR,DURHAM,NC 27710. BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234. CANC THERAPY & RES CTR S TEXAS,SAN ANTONIO,TX 78229. NCI,BETHESDA,MD 20889. ELI LILLY & CO,INDIANAPOLIS,IN 46285. FU NCRR NIH HHS [RR01346] NR 9 TC 11 Z9 11 U1 0 U2 0 PU RAPID SCIENCE PUBLISHERS PI LONDON PA 2-6 BOUNDARY ROW, LONDON, ENGLAND SE1 8NH SN 0959-4973 J9 ANTI-CANCER DRUG JI Anti-Cancer Drugs PD APR PY 1994 VL 5 IS 2 BP 151 EP 159 DI 10.1097/00001813-199404000-00005 PG 9 WC Oncology; Pharmacology & Pharmacy SC Oncology; Pharmacology & Pharmacy GA NH844 UT WOS:A1994NH84400005 PM 8049498 ER PT J AU SHIMADA, Y ROTHENBERG, M HILSENBECK, SG BURRIS, HA DEGEN, D VONHOFF, DD AF SHIMADA, Y ROTHENBERG, M HILSENBECK, SG BURRIS, HA DEGEN, D VONHOFF, DD TI ACTIVITY OF CPT-11 (IRINOTECAN HYDROCHLORIDE), A TOPOISOMERASE-I INHIBITOR, AGAINST HUMAN TUMOR COLONY-FORMING-UNITS SO ANTI-CANCER DRUGS LA English DT Article DE CLONING SYSTEM; CPT-11; HUMAN TUMOR COLONY-FORMING UNITS; IRINOTECAN ID CELL LUNG-CANCER; ANTITUMOR-ACTIVITY; PHASE-I; CAMPTOTHECIN; NSC-100880; INVITRO AB CPT-11 (irinotecan hydrochloride, 7-ethyl-10-[4-(piperidino)-1-piperidino] carbonyloxy-camptothecin) is a semisynthetic camptothecin derivative developed in Japan. The inhibitory activity of CPT-11 against human tumor colony-forming units from freshly explanted human tumors was explored using a soft agar cloning system. Final CPT-11 concentrations of 0.3-3.0 mu g/ml were used for a 1 h exposure. At a concentration of 3.0 mu g/ml antitumor activity was seen against colorectal, ovarian, nonsmall-cell lung, breast cancer and mesothelioma colony-forming units. CPT-11 should have activity against a broad spectrum of tumors in patients. C1 UNIV TEXAS,HLTH SCI CTR,SAN ANTONIO,TX 78229. NATL CANC CTR,DEPT MED,CHUO KU,TOKYO 104,JAPAN. CANC THERAPY & RES CTR S TEXAS,SAN ANTONIO,TX 78229. BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234. FU NCI NIH HHS [5P30CA54174] NR 20 TC 56 Z9 57 U1 0 U2 0 PU RAPID SCIENCE PUBLISHERS PI LONDON PA 2-6 BOUNDARY ROW, LONDON, ENGLAND SE1 8NH SN 0959-4973 J9 ANTI-CANCER DRUG JI Anti-Cancer Drugs PD APR PY 1994 VL 5 IS 2 BP 202 EP 206 DI 10.1097/00001813-199404000-00011 PG 5 WC Oncology; Pharmacology & Pharmacy SC Oncology; Pharmacology & Pharmacy GA NH844 UT WOS:A1994NH84400011 PM 8049503 ER PT J AU SMITH, KJ WAGNER, KF YEAGER, J SKELTON, HG LEDSKY, R AF SMITH, KJ WAGNER, KF YEAGER, J SKELTON, HG LEDSKY, R TI STAPHYLOCOCCUS-AUREUS CARRIAGE AND HIV-1 DISEASE - ASSOCIATION WITH INCREASED MUCOCUTANEOUS INFECTIONS AS WELL AS DEEP SOFT-TISSUE INFECTIONS AND SEPSIS SO ARCHIVES OF DERMATOLOGY LA English DT Note ID T-CELLS; COLONIZATION RP SMITH, KJ (reprint author), WALTER REED ARMY INST RES,WASHINGTON,DC 20307, USA. NR 8 TC 16 Z9 17 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0003-987X J9 ARCH DERMATOL JI Arch. Dermatol. PD APR PY 1994 VL 130 IS 4 BP 521 EP 522 DI 10.1001/archderm.130.4.521 PG 2 WC Dermatology SC Dermatology GA NG493 UT WOS:A1994NG49300024 PM 8166493 ER PT J AU WACK, RP ROSCELLI, JD AF WACK, RP ROSCELLI, JD TI CHLORIDE DEFICIENCY SYNDROME IN OLDER EXCLUSIVELY BREAST-FED INFANTS SO ARCHIVES OF PEDIATRICS & ADOLESCENT MEDICINE LA English DT Letter ID GROWTH; MILK C1 BROOKE ARMY MED CTR,DEPT PEDIAT,FT SAM HOUSTON,TX 78234. RP WACK, RP (reprint author), GEN HOSP 2,CMR 402,BOX 391,APO,AE 09180, USA. NR 20 TC 2 Z9 2 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 1072-4710 J9 ARCH PEDIAT ADOL MED JI Arch. Pediatr. Adolesc. Med. PD APR PY 1994 VL 148 IS 4 BP 438 EP 441 PG 4 WC Pediatrics SC Pediatrics GA NF055 UT WOS:A1994NF05500021 PM 8148951 ER PT J AU RABIN, J WILEY, R AF RABIN, J WILEY, R TI SWITCHING FROM FORWARD-LOOKING INFRARED TO NIGHT-VISION GOGGLES - TRANSITORY EFFECTS ON VISUAL RESOLUTION SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article AB Helmet mounted displays under development for rotary- and fixed-wing aircraft will allow the user to switch electronically between forward looking infrared (FLIR) and night vision goggle (NVG) sensors. These sensor transitions potentially involve large changes in display luminance which could transiently impair visual resolution and performance. The purpose of this study was to identify the display luminances which produce a transient reduction in vision when switching from a higher luminance (i.e., FLIR) to a lower luminance (i.e., NVG) display. A letter recognition task was used to assess the effect of luminance adaptation on visual resolution in five subjects. A significant reduction in letter recognition was observed in the first second after switching from simulated FLIR to simulated NVG's when the FLIR luminance was greater than or equal to 10 fL. By varying letter size, contrast, and exposure time, the magnitude and duration of visual loss after switching from a bright (49.2 fL) FLIR display were determined. The visual loss lasted up to 4 s, and included a 2x reduction in visual acuity, and a 3x reduction in contrast sensitivity. Large differences in sensor display luminance should be avoided to maintain high levels of visual performance and aviation safety. Design features or training may be necessary to achieve a proper balance between FLIR and NVG luminances which optimize performance and safety without sacrificing the quality of the sensor image. RP RABIN, J (reprint author), US ARMY AEROMED RES LAB,DIV AIRCREW HLTH & PERFORMANCE,FT RUCKER,AL 36362, USA. NR 12 TC 6 Z9 6 U1 0 U2 0 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD APR PY 1994 VL 65 IS 4 BP 327 EP 329 PG 3 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA NE707 UT WOS:A1994NE70700007 PM 8002913 ER PT J AU RABIN, J AF RABIN, J TI VISUAL-EVOKED POTENTIALS THROUGH NIGHT-VISION GOGGLES SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Note ID CONTRAST AB Night vision goggles (NVG's) have widespread use in military and civilian environments. NVG's amplify ambient illumination making performance possible when there is insufficient illumination for normal vision. While visual performance through NVG's is commonly assessed by measuring threshold functions such as visual acuity, few attempts have been made to assess vision through NVG's at suprathreshold levels of stimulation. Such information would be useful to better understand vision through NVG's across a range of stimulus conditions. In this study visual evoked potentials (VEP's) were used to evaluate vision through NVG's across a range of stimulus contrasts. The amplitude and latency of the VEP varied linearly with log contrast. A comparison of VEP's recorded with and without NVG's was used to estimate contrast attenuation through the device. VEP's offer an objective, electrophysiological tool to assess visual performance through NVG's at both threshold and suprathreshold levels of visual stimulation. RP RABIN, J (reprint author), US ARMY AEROMED RES LAB,DIV SENSORY RES,POB 620577,FT RUCKER,AL 36362, USA. NR 11 TC 2 Z9 2 U1 0 U2 0 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD APR PY 1994 VL 65 IS 4 BP 345 EP 347 PG 3 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA NE707 UT WOS:A1994NE70700012 PM 8002918 ER PT J AU KOTULAK, JC MORSE, SE AF KOTULAK, JC MORSE, SE TI FOCUS ADJUSTMENT EFFECTS ON VISUAL-ACUITY AND OCULOMOTOR BALANCE WITH AVIATOR NIGHT-VISION DISPLAYS SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Note ID INSTRUMENT AB Sixteen U.S. Army aviators, who were given training on focus adjustment technique with aviator night vision goggles (NVG), showed an Improvement in visual acuity with focus adjustment compared to a fixed infinity focus control. The long-term effect of focus adjustment on vision was not measured; however, adjustment accuracy was found to be generally within acceptable limits based on computer modeling and available physiologic data. Fixed focus eyepieces that tire set to a low minus power may partially compensate for instrument myopia, but they may not optimize visual acuity to the extent that adjustable focus eyepieces do. Eyepiece adjustment proficiency with present night vision devices can he improved through training that emphasizes focusing to the least possible minus dioptric power. Future night vision displays can minimize focus misadjustment by providing a tactile zero marking, a limited dioptric adjustment range, and a focusing knob capable of finer adjustment than is available with current NVG's. RP KOTULAK, JC (reprint author), US ARMY AEROMED RES LAB,VISUAL SCI BRANCH,POB 620577,FT RUCKER,AL 36362, USA. NR 17 TC 5 Z9 5 U1 0 U2 1 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD APR PY 1994 VL 65 IS 4 BP 348 EP 352 PG 5 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA NE707 UT WOS:A1994NE70700013 PM 8002919 ER PT J AU LAIRD, JR CARTER, AJ KUFS, WM FARB, A PREWITT, KC WORTHAM, DC AF LAIRD, JR CARTER, AJ KUFS, WM FARB, A PREWITT, KC WORTHAM, DC TI PLACEMENT AND ANGIOGRAPHIC PATENCY OF THE STRECKER CORONARY STENT SO CATHETERIZATION AND CARDIOVASCULAR DIAGNOSIS LA English DT Article DE STENT; YORKSHIRE SWINE; PATENCY ID BALLOON ANGIOPLASTY; RESTENOSIS; MODEL; OCCLUSION; ARTERIES; SWINE AB The Strecker stent is a newer, balloon-expandable vascular prosthesis consisting of a single tantalum filament knitted into a flexible mesh tube. To test the placement characteristics and patency of this device, we implanted 29 stents in the coronary arteries of 24 juvenile Yorkshire swine. Seventeen stents were placed in the left anterior descending artery, and 12 were placed in the left circumflex system. All stents were deployed successfully. Four animals died within the first 24 hr of anesthesia-related complications. The remaining animals were sacrificed at 24 hr, 1 week, 2 weeks, or 4 weeks. Follow-up angiography demonstrated the patency of all stents. There were no episodes of stent migration or side branch occlusion. The Strecker stent has several favorable characteristics, including its unique delivery system, ease of deployment, flexibility, radiopacity, and radial strength. There was 100% patency at up to 4 weeks in this animal model. Further studies are required to define whether the knitted mesh design offers any advantage over previous models. (C) 1994 Wiley-Liss, Inc. C1 ARMED FORCES INST PATHOL,WASHINGTON,DC 20306. RP LAIRD, JR (reprint author), WALTER REED ARMY MED CTR,CARDIOL SERV,WASHINGTON,DC 20307, USA. NR 22 TC 8 Z9 8 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0098-6569 J9 CATHETER CARDIO DIAG JI Catheter. Cardiovasc. Diagn. PD APR PY 1994 VL 31 IS 4 BP 322 EP 329 DI 10.1002/ccd.1810310415 PG 8 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA NC625 UT WOS:A1994NC62500014 PM 8055575 ER PT J AU ARROYO, CM WADE, JV ICHIMORI, K NAKAZAWA, H AF ARROYO, CM WADE, JV ICHIMORI, K NAKAZAWA, H TI THE SCAVENGING OF HYDROXYL RADICAL ((OH)-O-CENTER-DOT) BY A PROSTACYCLIN ANALOG, TAPROSTENE SO CHEMICO-BIOLOGICAL INTERACTIONS LA English DT Article DE PGI(2); TAPROSTENE; REACTIVE OXYGEN SPECIES; EPR/SPIN TRAPPING ID SPIN TRAP; LEUKOCYTES; CHEMISTRY; PEROXIDE; OXYGEN AB A possible mechanism by which prostacyclin (PGI(2)) analogues provide beneficial effects including improved survival in shock experimentally induced by endotoxin, polytrauma or hypovolemia was studied. Since several studies have implicated oxygen free radical-mediated tissue damage, we investigated whether PGI(2)-analogues exert their 'cytoprotective' effects by inhibiting overproduction of oxygen free radicals. For this reason, the efficiency of Taprostene to scavenge hydroxyl radicals(.OH) and to possibly prevent the subsequent formation of reactive oxygen species was studied. Competition experiments were performed in which the .OH generated by H2O2/Fe2+ abstracted a hydrogen from Taprostene (CG-4203) [5Z,13E,9,11,15S)-2,3,4-trinor-1,5-inter-m-phenylene-6,9-epoxy-11,15-dihydroxy-15-cyclohexyl-16,17, 18,19,20-pentanor-pros ta-5,13-dienoic acid sodium salt], and the resulting carbon-centered radical was trapped with the spin trap 3,3,5,5-tetramethyl-1-pyrroline-N-oxide (M(4)PO). This spin trap reacted with .OH to yield an M(4)PO-OH spin adduct observable by Electron Paramagnetic Resonance (EPR) spectroscopy and resulted in the rate constant, k(2) = 1.5 x 10(10) M(-1)s(-1), for the reaction between . OH and Taprostene. The results show that Taprostene is an efficient .OH scavenger. In addition, reactions of hypochlorous ion ((-)OCL) with hydrogen peroxide (H2O2) in the presence of Taprostene were monitored using the spin trap 5,5-dimethyl-1-pyrroline-N-oxide (DMPO) and M(4)PO dissolved in deuterium oxide. C1 TOKAI UNIV,SCH MED,DEPT PHYSIOL,ISEHARA,KANAGAWA 25911,JAPAN. RP ARROYO, CM (reprint author), USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010, USA. NR 25 TC 10 Z9 10 U1 0 U2 1 PU ELSEVIER SCI IRELAND LTD PI CLARE PA CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE, IRELAND SN 0009-2797 J9 CHEM-BIOL INTERACT JI Chem.-Biol. Interact. PD APR PY 1994 VL 91 IS 1 BP 29 EP 38 DI 10.1016/0009-2797(94)90004-3 PG 10 WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology GA NL812 UT WOS:A1994NL81200003 PM 8194123 ER PT J AU BUESCHER, TM MORITZ, DM KILLYON, GW AF BUESCHER, TM MORITZ, DM KILLYON, GW TI RESECTION OF CHEST-WALL AND CENTRAL VEINS FOR INVASIVE CUTANEOUS ASPERGILLUS INFECTION IN AN IMMUNOCOMPROMISED PATIENT SO CHEST LA English DT Note ID SEPTIC THROMBOSIS; CATHETERS AB Primary cutaneous invasive Aspergillus infection at a Hickman catheter site led to chest wall involvement and central venous suppurative thrombophlebitis in a patient with relapsed acute myelogenous leukemia. Therapy included high-dose amphotericin B, serial wound debridements pending bone marrow recovery, and definitive resection of the infected chest wall and thrombosed internal jugular, subclavian, and innominate veins. To our knowledge, this procedure for control of invasive fungal infection has not been reported previously. C1 BROOKE ARMY MED CTR,DIV PLAST & RECONSTRUCT SURG,FT SAM HOUSTON,TX 78234. BROOKE ARMY MED CTR,DIV CARDIOTHORAC SURG,FT SAM HOUSTON,TX 78234. UNIFORMED SERV UNIV HLTH SCI,DEPT SURG,BETHESDA,MD 20814. NR 6 TC 11 Z9 11 U1 0 U2 1 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 SN 0012-3692 J9 CHEST JI Chest PD APR PY 1994 VL 105 IS 4 BP 1283 EP 1285 DI 10.1378/chest.105.4.1283 PG 3 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA NE954 UT WOS:A1994NE95400070 PM 8162774 ER PT J AU BOLINGER, BS WINSLOW, MTM AF BOLINGER, BS WINSLOW, MTM TI TRANSESOPHAGEAL ECHOCARDIOGRAPHIC DIAGNOSIS OF A RUPTURED TRICUSPID-VALVE CHORDAE TENDINAE AS THE ETIOLOGY FOR CARDIOGENIC-SHOCK SO CHEST LA English DT Note AB Acute tricuspid insufficiency is an uncommon cause of cardiogenic shock. Previous reported cases have involved patients with right ventricular infarction. We report a case of acute tricuspid insufficiency causing cardiogenic shock in a patient without evidence of right ventricular infarction. Transesophageal echocardiography (TEE) was used to diagnose a ruptured chordae tendinae as the etiology of tricuspid insufficiency. RP BOLINGER, BS (reprint author), TRIPLER ARMY MED CTR,DEPT MED,SERV CARDIOL,HONOLULU,HI 96859, USA. NR 7 TC 1 Z9 1 U1 0 U2 0 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 SN 0012-3692 J9 CHEST JI Chest PD APR PY 1994 VL 105 IS 4 BP 1286 EP 1288 DI 10.1378/chest.105.4.1286 PG 3 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA NE954 UT WOS:A1994NE95400072 PM 8162776 ER PT J AU SFIKAKIS, PP OGLESBY, R SFIKAKIS, P TSOKOS, GC AF SFIKAKIS, PP OGLESBY, R SFIKAKIS, P TSOKOS, GC TI B7/BB1 PROVIDES AN IMPORTANT COSTIMULATORY SIGNAL FOR CD3-MEDIATED T-LYMPHOCYTE PROLIFERATION IN PATIENTS WITH SYSTEMIC LUPUS-ERYTHEMATOSUS (SLE) SO CLINICAL AND EXPERIMENTAL IMMUNOLOGY LA English DT Article DE T-CELL ACTIVATION; CD28 ANTIGEN; B7/BB1 ANTIGEN; SYSTEMIC LUPUS ERYTHEMATOSUS ID SOLUBLE INTERLEUKIN-2 RECEPTORS; CELL ACTIVATION; MESSENGER-RNA; CD28; ANTIGEN; INVITRO; RESPONSIVENESS; INDUCTION; MICE; B7 AB Successful T cell activation via the T cell receptor (TCR)/CD3 complex requires at least one contact-dependent second signal delivered by costimulatory molecules, including the B7/BB1 molecule, that are present on antigen-presenting cells (APC). SLE is characterized by multiple complex lymphocyte abnormalities of undefined molecular origin. It is currently unclear whether an intrinsic defect of T cell or an underlying APC dysfunction is responsible for defective in vitro proliferation of T cells from patients with SLE. We planned the present experiments to ask whether the TCR/CD3-mediated and B7/BB1-costimulated T cell proliferation is normal in these patients. We used enriched T cell populations that were stimulated with an anti-CD3 MoAb in the presence of controlled quantities of functional B7/BB1 antigen. Freshly isolated T cells from 17 SLE patients (10 and seven patients with either active or inactive disease, respectively) and 11 normal individuals were cocultured with irradiated B7/BB1-transfected P815 cells or parental P815 cells in the presence of OKT3 MoAb at optimal and suboptimal concentrations for 2.5-7 days. Normal or SLE T cells responded similarly to stimulation via anti-CD3, in the absence of B7/BB1 antigen. A several-fold increase in T cell proliferation in the presence of B7/BB1 antigen was observed. Proliferation was inhibited in the presence of anti-B7/BB1 MoAb, but not with control MoAbs. Interestingly, dose-response curves and time kinetics of B7/BB1 costimulation were similar in T cells from patients with either active or inactive SLE at the time of study, and normal individuals. In addition, no differences in the IL-2 receptor release by T cells cultured under these conditions were observed between SLE patients and normal individuals. These results demonstrate that CD28 signalling is not intrinsically impaired in patients with SLE; further studies to investigate whether abnormal B7/BB1 expression is involved in the autoimmune process are needed. C1 UNIFORMED SERV UNIV HLTH SCI,DEPT MED,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,RHEUMATOL & CLIN IMMUNOL SERV,WASHINGTON,DC 20307. RP SFIKAKIS, PP (reprint author), LAIKON GEN HOSP,DEPT PROPAEDEUT MED 1,17 AG THOMA STR,GR-11527 ATHENS,GREECE. NR 49 TC 23 Z9 23 U1 0 U2 0 PU BLACKWELL SCIENCE LTD PI OXFORD PA OSNEY MEAD, OXFORD, OXON, ENGLAND OX2 0EL SN 0009-9104 J9 CLIN EXP IMMUNOL JI Clin. Exp. Immunol. PD APR PY 1994 VL 96 IS 1 BP 8 EP 14 PG 7 WC Immunology SC Immunology GA ND728 UT WOS:A1994ND72800002 PM 7512010 ER PT J AU WATT, G STRICKMAN, D AF WATT, G STRICKMAN, D TI LIFE-THREATENING SCRUB TYPHUS IN A TRAVELER RETURNING FROM THAILAND SO CLINICAL INFECTIOUS DISEASES LA English DT Note ID IMPORTED RICKETTSIAL DISEASE; DOXYCYCLINE PROPHYLAXIS AB Scrub typhus is not one of the more commonly encountered diseases in travelers returning from Asia, but it deserves more consideration in view of its severity and the availability of specific chemotherapy and chemoprophylaxis. We describe a case of scrub typhus that was associated with coma and multiorgan failure in a traveler returning to the United States from Thailand. The diagnosis was made only retrospectively despite a travel history and clinical signs that suggested infection with Rickettsia tsutsugamushi. No specific therapy was given, and marked neurological impairment persisted 6 months after the beginning of the illness. An increased awareness of scrub typhus is a prerequisite for recommending prophylaxis and instituting prompt therapy. C1 ARMED FORCES RES INST MED SCI,DEPT ENTOMOL,BANGKOK,THAILAND. ARMED FORCES RES INST MED SCI,DEPT MED,BANGKOK,THAILAND. NR 14 TC 61 Z9 62 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD APR PY 1994 VL 18 IS 4 BP 624 EP 626 PG 3 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA NE074 UT WOS:A1994NE07400019 PM 8038320 ER PT J AU ATKINS, JL GRILLO, FG AF ATKINS, JL GRILLO, FG TI LYSINE INHIBITS ARGININE TRANSPORT AND NITRIC-OXIDE PRODUCTION IN L-CELLS SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,DEPT NEPHROL,WASHINGTON,DC 20307. RI Atkins, James/B-3577-2011 NR 0 TC 1 Z9 1 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 SN 0009-9279 J9 CLIN RES JI Clin. Res. PD APR PY 1994 VL 42 IS 2 BP A256 EP A256 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA NF020 UT WOS:A1994NF02000823 ER PT J AU BIRX, DL MICHAEL, N REDFIELD, R REITZ, M BURKE, D BLATTNER, W AF BIRX, DL MICHAEL, N REDFIELD, R REITZ, M BURKE, D BLATTNER, W TI HIV-1-INFECTED LABORATORY WORKERS - PROFILE OF CELLULAR-RESPONSES TO HIV-1 ANTIGENS AND ALTERATION WITH ACTIVE IMMUNIZATION SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,DEPT RETROVIRAL RES,WASHINGTON,DC 20307. NCI,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 SN 0009-9279 J9 CLIN RES JI Clin. Res. PD APR PY 1994 VL 42 IS 2 BP A156 EP A156 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA NF020 UT WOS:A1994NF02000258 ER PT J AU CROSS, AS MORRISON, DC AF CROSS, AS MORRISON, DC TI EVIDENCE FOR A LIPOPOLYSACCHARIDE-RECEPTOR MEDIATED MICROBICIDAL PATHWAY IN MACROPHAGES SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,WASHINGTON,DC 20307. UNIV KANSAS,MED CTR,KANSAS CITY,KS 66103. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 SN 0009-9279 J9 CLIN RES JI Clin. Res. PD APR PY 1994 VL 42 IS 2 BP A152 EP A152 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA NF020 UT WOS:A1994NF02000233 ER PT J AU DRABICK, JJ RAMSEY, K MCCLAIN, JB CRYZ, S CROSS, AS AF DRABICK, JJ RAMSEY, K MCCLAIN, JB CRYZ, S CROSS, AS TI THE EFFECT OF PASSIVE IMMUNOTHERAPY WITH HYPERIMMUNE AND NON-HYPERIMMUNE GAMMA-GLOBULIN ON CIRCULATING ANTIGEN-SPECIFIC B-CELLS IN HUMAN VOLUNTEERS SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,DEPT BACTERIAL DIS,WASHINGTON,DC 20307. NR 0 TC 1 Z9 1 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 SN 0009-9279 J9 CLIN RES JI Clin. Res. PD APR PY 1994 VL 42 IS 2 BP A299 EP A299 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA NF020 UT WOS:A1994NF02001063 ER PT J AU DRABICK, JJ STOUTE, J LINDLER, L GORDON, D SADOFF, J BALLOU, WR AF DRABICK, JJ STOUTE, J LINDLER, L GORDON, D SADOFF, J BALLOU, WR TI EPITOPE MAPPING OF A FUNCTIONAL HUMAN MAB AGAINST PLASMODIUM-FALCIPARUM USING A RANDOM HEXAPEPTIDE FILAMENTOUS PHAGE EXPRESSION LIBRARY SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,DEPT MOLEC SCI,WASHINGTON,DC 20307. WALTER REED ARMY INST RES,DEPT IMMUNOL,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 SN 0009-9279 J9 CLIN RES JI Clin. Res. PD APR PY 1994 VL 42 IS 2 BP A283 EP A283 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA NF020 UT WOS:A1994NF02000974 ER PT J AU GREILICH, PE CARR, ME ZEKERT, SL AF GREILICH, PE CARR, ME ZEKERT, SL TI EFFECTS OF DESMOPRESSIN ACETATE (DDAVP) ON PLATELET FORCE DEVELOPMENT IN PATIENTS BLEEDING EXCESSIVELY AFTER CARDIOPULMONARY BYPASS (CPB) SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,DEPT ANESTHESIOL,WASHINGTON,DC 20307. VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,COAGULAT SPECIAL STUDIES LAB,RICHMOND,VA 23298. NR 2 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 SN 0009-9279 J9 CLIN RES JI Clin. Res. PD APR PY 1994 VL 42 IS 2 BP A186 EP A186 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA NF020 UT WOS:A1994NF02000425 ER PT J AU KIM, JH SITZ, KV RATTO, S MCLINDEN, RJ TENCER, K MOSCA, JD BIRX, DL REDFIELD, RR AF KIM, JH SITZ, KV RATTO, S MCLINDEN, RJ TENCER, K MOSCA, JD BIRX, DL REDFIELD, RR TI CYTOKINE GENE-THERAPY FOR HIV - IMMUNOLOGICAL EFFECTS OF ANTIGEN-INDUCIBLE EXPRESSION OF INTERLEUKIN-7 IN HIV-SPECIFIC AND TETANUS-TOXOID-SPECIFIC T-CELLS SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,WASHINGTON,DC 20307. HENRY M JACKSON FDN,ROCKVILLE,MD. NR 0 TC 1 Z9 1 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 SN 0009-9279 J9 CLIN RES JI Clin. Res. PD APR PY 1994 VL 42 IS 2 BP A282 EP A282 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA NF020 UT WOS:A1994NF02000972 ER PT J AU NATH, J POWLEDGE, A AF NATH, J POWLEDGE, A TI EFFECT OF NITRIC-OXIDE MODULATORS ON HUMAN NEUTROPHIL INFLAMMATORY RESPONSES SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,DEPT HEMATOL,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 SN 0009-9279 J9 CLIN RES JI Clin. Res. PD APR PY 1994 VL 42 IS 2 BP A148 EP A148 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA NF020 UT WOS:A1994NF02000211 ER PT J AU SALATA, KF TSOKOS, GC VASSILOPOULOS, D AF SALATA, KF TSOKOS, GC VASSILOPOULOS, D TI SPHINGOMYELINASE (SMASE)-MEDIATED INCREASE IN INTRACELLULAR CA++ CONCENTRATION IN HUMAN MONOCYTES SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,DEPT CLIN INVEST,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 SN 0009-9279 J9 CLIN RES JI Clin. Res. PD APR PY 1994 VL 42 IS 2 BP A274 EP A274 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA NF020 UT WOS:A1994NF02000924 ER PT J AU VASSILOPOULOS, D SALATA, KF TSOKOS, GC AF VASSILOPOULOS, D SALATA, KF TSOKOS, GC TI EXOGENOUS SPHINGOMYELINASE INCREASES INTRACELLULAR CALCIUM LEVELS AND INDUCES PROLIFERATIVE RESPONSE IN HUMAN T-LYMPHOCYTES SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 SN 0009-9279 J9 CLIN RES JI Clin. Res. PD APR PY 1994 VL 42 IS 2 BP A311 EP A311 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA NF020 UT WOS:A1994NF02001134 ER PT J AU WRIGHT, DG FARRINGTON, GK ODONNELL, C HARTMAN, KR RUBINSTEIN, DB AF WRIGHT, DG FARRINGTON, GK ODONNELL, C HARTMAN, KR RUBINSTEIN, DB TI AUTOANTIBODIES TO THE LEUKOCYTE ALPHA-M-BETA-2 INTEGRIN GLYCOPROTEINS IN HIV DISEASE SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 BOSTON UNIV,SCH MED,HEMATOL SECT,BOSTON,MA 02118. WALTER REED ARMY INST RES,WASHINGTON,DC 20307. REPLIGEN CORP,CAMBRIDGE,MA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 SN 0009-9279 J9 CLIN RES JI Clin. Res. PD APR PY 1994 VL 42 IS 2 BP A156 EP A156 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA NF020 UT WOS:A1994NF02000254 ER PT J AU YUAN, CM BOHEN, EM CAROME, MA AF YUAN, CM BOHEN, EM CAROME, MA TI INDUCTION OF HEAT-SHOCK PROTEINS REDUCES CYCLOSPORINE-A TOXICITY IN LLCPK CELLS SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,NEPHROL SERV,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 SN 0009-9279 J9 CLIN RES JI Clin. Res. PD APR PY 1994 VL 42 IS 2 BP A221 EP A221 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA NF020 UT WOS:A1994NF02000627 ER PT J AU FLEMISH, JR SCHAUER, SN WITTSTRUCK, R LANDSTRASS, MI PLANO, MA AF FLEMISH, JR SCHAUER, SN WITTSTRUCK, R LANDSTRASS, MI PLANO, MA TI GROWTH AND CHARACTERIZATION OF PHOSPHORUS-DOPED DIAMOND FILMS SO DIAMOND AND RELATED MATERIALS LA English DT Article; Proceedings Paper CT 4th European Conference on Diamond, Diamond-like and Related Materials (Diamond Films 93) CY SEP 20-24, 1993 CL ALBUFEIRA, PORTUGAL SP AEA TECHNOL, SURF TECHNOL, HARWELL LAB, ASTEX, COMMISS EUROPEAN COMMUNITIES, DG TEER COATING SERV LTD, DIAMOND & RELATED MAT, DRUKKER INT BV, GENASYSTEMS INC, KOBE STEEL USA INC, ELECTR MAT CTR, NORTON DIAMOND FILM, RENISHHAW TRANSDUCER SYST LTD, US DEPT DEF ID POLYCRYSTALLINE DIAMOND; DEVICE APPLICATIONS; EPITAXIAL-FILMS; MICROWAVE AB Phosphorus-doped diamond films were grown from CH4 and H-2 using d.c. and microwave plasmas with PH3 as the dopant source. The P incorporation which was quantified using secondary ion mass spectrometry varies by more than two orders of magnitude for a given ratio of PH3 to CH4 in the gas phase. The lowest incorporation occurs in single-crystal (homoepitaxial) layers and the highest occurs in the polycrystalline films with the smallest grain size, indicating that P incorporates preferentially at grain boundaries. Conductivities of approximately 10(-10) to 10(-9) OMEGA-1 cm-1 were measured at room temperature for P-doped films. Significant levels of Si and B impurities are unintentionally present in these films, which may compensate any potential donor behavior of P. The homoepitaxial films were characterized by high resolution X-ray diffraction. The peak widths at half-maximum for the (004) reflection for all films are comparable with that of the bare IIa natural diamond substrates (0.050-degrees), regardless of thickness or doping, suggesting that the crystalline quality of the epitaxial layers is as good or better than that of the substrates. C1 CRYSTALLUME,MENLO PK,CA 94025. RP FLEMISH, JR (reprint author), USA,RES LAB,FT MONMOUTH,NJ 07703, USA. NR 17 TC 20 Z9 20 U1 1 U2 6 PU ELSEVIER SCIENCE SA LAUSANNE PI LAUSANNE 1 PA PO BOX 564, 1001 LAUSANNE 1, SWITZERLAND SN 0925-9635 J9 DIAM RELAT MATER JI Diam. Relat. Mat. PD APR PY 1994 VL 3 IS 4-6 BP 672 EP 676 DI 10.1016/0925-9635(94)90246-1 PG 5 WC Materials Science, Multidisciplinary SC Materials Science GA NN160 UT WOS:A1994NN16000073 ER PT J AU BAKER, JA KILLGORE, KJ FOSTER, SA AF BAKER, JA KILLGORE, KJ FOSTER, SA TI POPULATION VARIATION IN SPAWNING CURRENT SPEED SELECTION IN THE BLACKTAIL SHINER, CYPRINELLA-VENUSTA (PISCES, CYPRINIDAE) SO ENVIRONMENTAL BIOLOGY OF FISHES LA English DT Article DE CREVICE SPAWNING; FISH; REPRODUCTIVE BEHAVIOR ID OUTLET STREAMS; BEHAVIOR; NOTROPIS; INLET AB Many stream fishes lay demersal eggs. Some species simply scatter the eggs across the substrate, but many place the eggs in protected sites such as crevices (e.g., Cyprinidae: Cyprinella). Eggs laid in crevices may experience increased development times or lower embryo survival due to reduced water exchange rates compared to more open egg deposition sites. If so, the presence of an appreciable current near the crevice may be important for insuring water exchange. However, currents that are too strong may prevent complete insemination or prevent the eggs from adhering to the substratum before they are washed from the crevice. Thus, current speed preferences for spawning may be under strong stabilizing selection. Representatives of four populations of a crevice spawning stream fish (blacktail shiner, Cyprinella venusta), representing environments ranging from a swift stream to a lake, were studied in stream tanks to evaluate female spawning current use. The observed frequency of use of spawning currents was significantly different from random in all populations. Low current speeds were generally avoided, and a speed of ca. 30 cm sec-1 was used most often. However, significant differences were observed among populations, and the variation correlated well with the apparent range of current speeds found in the four environments. Although other possible explanations cannot be dismissed, the results are consistent with the hypothesis that the populations have become adapted to their local current regimes. C1 USA,ENGINEER WATERWAYS EXPT STN,ENVIRONM LAB,VICKSBURG,MS 39180. RP BAKER, JA (reprint author), UNIV ARKANSAS,DEPT BIOL SCI,FAYETTEVILLE,AR 72701, USA. NR 26 TC 6 Z9 6 U1 0 U2 2 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 0378-1909 J9 ENVIRON BIOL FISH JI Environ. Biol. Fishes PD APR PY 1994 VL 39 IS 4 BP 357 EP 364 DI 10.1007/BF00004805 PG 8 WC Ecology; Marine & Freshwater Biology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA NE006 UT WOS:A1994NE00600004 ER PT J AU NAM, SI ROEBUCK, BD WALSH, ME AF NAM, SI ROEBUCK, BD WALSH, ME TI UPTAKE AND LOSS OF WHITE PHOSPHORUS IN AMERICAN KESTRELS SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article DE WHITE PHOSPHORUS; YELLOW PHOSPHORUS; KESTRELS; UPTAKE; BIOACCUMULATION AB American kestrels (Falco sparverius) exposed to a diet containing white phosphorus (P4) had detectable quantities Of P4 only in their fatty tissues. As early as 24 h postdosing, P4 was found in the fat depots and skin but not in other tissues such as the brain, heart, intestine, liver, kidney, and muscle. After 7 d of continuous exposure to P4-Containing diet (6.4 mug P4 per gram of diet), the skin but not fat depots showed significant accumulation of P4. When P4-containing diet (6.4 mug P4 per gram of diet) was fed for 2 d followed by 3 d of feeding a diet containing less P4 (0.7 mug P4 per gram of diet), P4 was not detectable in the tissues. Upon refeeding with the higher dietary concentration Of P4, P4 was again detectable in skin and fat. This cyclic dosing regimen indicates that tissue levels are sensitive to dietary levels of P4. C1 USA,COLD REG RES & ENGN LAB,HANOVER,NH 03755. RP NAM, SI (reprint author), DARTMOUTH COLL,DEPT PHARMACOL & TOXICOL,HANOVER,NH 03755, USA. NR 24 TC 14 Z9 14 U1 1 U2 2 PU SETAC PRESS PI PENSACOLA PA 1010 NORTH 12TH AVE, PENSACOLA, FL 32501-3370 SN 0730-7268 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD APR PY 1994 VL 13 IS 4 BP 637 EP 641 DI 10.1897/1552-8618(1994)13[637:UALOWP]2.0.CO;2 PG 5 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA NB182 UT WOS:A1994NB18200013 ER PT J AU COWAN, DN ROBINSON, JR JONES, BH POLLY, DW BERREY, BH AF COWAN, DN ROBINSON, JR JONES, BH POLLY, DW BERREY, BH TI CONSISTENCY OF VISUAL ASSESSMENTS OF ARCH HEIGHT AMONG CLINICIAN SO FOOT & ANKLE INTERNATIONAL LA English DT Article AB Flat feet and high-arched feet have been cited as risk factors for musculoskeletal injury and functional problems among runners and other active individuals, although there are no established quantitative definitions or measures for assessing either condition. As part of a larger study, four-plane photographs were made of the weight-bearing right foot of 246 young male Army trainees. These photographs were independently evaluated by six clinicians and rated on a scale of clearly flat-footed (category 1) to clearly high arched (category 5). There was much interclinician variability in the assessments, even for extremes of foot type. The probability of a clinician assessing a foot as clearly flat, given that another clinician had rated the foot as clearly flat, ranged from 0.32 to 0.79, with a median probability of 0.57, while for clearly high-arched feet, probabilities ranged from 0.0 to 1.00, with a median of 0.17. These findings demonstrate the need for objective standards and quantitative methods of evaluating foot morphology. RP COWAN, DN (reprint author), WALTER REED ARMY INST RES,DEPT EPIDEMIOL,WASHINGTON,DC 20307, USA. NR 0 TC 42 Z9 42 U1 0 U2 4 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 1071-1007 J9 FOOT ANKLE INT JI Foot Ankle Int. PD APR PY 1994 VL 15 IS 4 BP 213 EP 217 PG 5 WC Orthopedics SC Orthopedics GA PA074 UT WOS:A1994PA07400011 PM 7951957 ER PT J AU MARUYAMA, T SCHODEL, F IINO, S KOIKE, K YASUDA, K PETERSON, D MILICH, DR AF MARUYAMA, T SCHODEL, F IINO, S KOIKE, K YASUDA, K PETERSON, D MILICH, DR TI DISTINGUISHING BETWEEN ACUTE AND SYMPTOMATIC CHRONIC HEPATITIS-B VIRUS-INFECTION SO GASTROENTEROLOGY LA English DT Article ID CIRCULATING IMMUNE-COMPLEXES; CHRONIC LIVER-DISEASE; CORE ANTIGEN; IGM ANTIBODY; SERUM; RESPONSES; SEROLOGY; CARRIERS AB Background/Aims: Differentiating between an acute hepatitis B (AH-B) infection and an acute exacerbation of a chronic hepatitis B (CH-B) infection can present a problem for the clinician. The only current serological method of distinguishing between acute and symptomatic chronic hepatitis B virus (HBV) infection is the immunoglobulin M antibody to hepatitis B core antigen (anti-HBc) assay, which can be problematic. Therefore, in an attempt to better distinguish between acute and chronic HBV infection, sera from 26 patients with AH-B and 53 patients with CH-B were compared in a variety of experimental immunoassays. Methods: Experimental assays have been designed to detect free antibody to hepatitis B e antigen (anti-HBe), hepatitis B e antigen (HBeAg)/anti-HBe immune complexes (ICs), and hepatitis B surface antigen (HBsAg)/antibody to hepatitis B surface antigen (anti-HBs) in the presence of excess antigen. An additional assay was developed to detect a novel anti-HBc specificity, designated antibody to woodchuck hepatitis virus (anti-HBc(w)), which cross-reacts with the core antigen of the woodchuck hepatitis virus. Results: Sera from patients with CH-B showed significantly higher levels of free anti-HBe, HBeAg/anti-HBe ICs, and HBsAg/anti-HBs ICs compared with AH-B patient sera. Furthermore, patients with CH-B consistently produced high titer antiHBc(w), whereas patients with AH-B produced little or no anti-HBc(w) antibody. Conclusions: The serology of AH-B infection and symptomatic CH-B infection can be distinguished using a variety of experimental immunoassays in addition to the immunoglobulin M anti-HBC assay. C1 Scripps Res Inst, RES INST, DEPT MOLEC BIOL, LA JOLLA, CA 92037 USA. WALTER REED ARMY INST RES, DEPT BACTERIAL DIS, WASHINGTON, DC 20307 USA. ST MARIANNA UNIV, SCH MED, INST MED SCI, KAWASAKI, KANAGAWA 213, JAPAN. UNIV TOKYO, FAC MED, DEPT INTERNAL MED 1, TOKYO 113, JAPAN. VIRGINIA COMMONWEALTH UNIV, DEPT BIOCHEM, RICHMOND, VA 23284 USA. NR 38 TC 40 Z9 47 U1 0 U2 1 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0016-5085 J9 GASTROENTEROLOGY JI Gastroenterology PD APR PY 1994 VL 106 IS 4 BP 1006 EP 1015 PG 10 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA NE093 UT WOS:A1994NE09300022 PM 7511551 ER PT J AU BROWN, W SMITH, P LE, M HUFFER, W BOEDEKER, E AF BROWN, W SMITH, P LE, M HUFFER, W BOEDEKER, E TI HISTOMORPHOMETRIC ESTIMATION OF THE UPTAKE OF POLYSTYRENE PARTICLES BY INTESTINAL LYMPHOID-TISSUES SO GASTROENTEROLOGY LA English DT Meeting Abstract C1 VET ADM MED CTR,DENVER,CO 80220. UNIV COLORADO,SCH MED,DENVER,CO 80202. WALTER REED ARMY INST RES,WASHINGTON,DC 20307. NR 0 TC 2 Z9 2 U1 1 U2 1 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0016-5085 J9 GASTROENTEROLOGY JI Gastroenterology PD APR PY 1994 VL 106 IS 4 SU S BP A656 EP A656 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA NH909 UT WOS:A1994NH90902611 ER PT J AU BROWN, WR LE, M REID, R BOEDEKER, E AF BROWN, WR LE, M REID, R BOEDEKER, E TI HISTOCHEMICAL AND IMMUNOHISTOCHEMICAL CHARACTERIZATION OF RABBIT PEYERS-PATCHES SO GASTROENTEROLOGY LA English DT Meeting Abstract C1 VET ADM MED CTR,DENVER,CO 80220. UNIV COLORADO,MED CTR,DENVER,CO 80202. WALTER REED ARMY INST RES,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0016-5085 J9 GASTROENTEROLOGY JI Gastroenterology PD APR PY 1994 VL 106 IS 4 SU S BP A657 EP A657 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA NH909 UT WOS:A1994NH90902614 ER PT J AU BROWN, WR LE, M REID, R BHAGAT, H BOEDEKER, E AF BROWN, WR LE, M REID, R BHAGAT, H BOEDEKER, E TI A HISTOCHEMICAL AND IMMUNOHISTOCHEMICAL ANALYSIS OF THE UPTAKE OF MICROPARTICLES BY RABBIT PEYERS-PATCHES - UPTAKE BY BOTH M-CELLS AND NON-M CELLS SO GASTROENTEROLOGY LA English DT Meeting Abstract C1 VET ADM MED CTR,DENVER,CO 80220. UNIV COLORADO,MED CTR,DENVER,CO 80202. WALTER REED ARMY INST RES,WASHINGTON,DC 20307. ORAVEX INC,CAMBRIDGE,MA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0016-5085 J9 GASTROENTEROLOGY JI Gastroenterology PD APR PY 1994 VL 106 IS 4 SU S BP A657 EP A657 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA NH909 UT WOS:A1994NH90902612 ER PT J AU CREMINS, J SALATA, K KIKENDALL, W HERSHEY, J NAIR, P WONG, RKH AF CREMINS, J SALATA, K KIKENDALL, W HERSHEY, J NAIR, P WONG, RKH TI PNA BINDING TO ISOLATED ISOLATED COLONOCYTES MAY DIAGNOSE COLON-CARCINOMA SO GASTROENTEROLOGY LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,GASTROENTEROL SERV,WASHINGTON,DC 20307. USDA,LIPID NUTR LAB,BELTSVILLE,MD 20705. NR 0 TC 6 Z9 5 U1 2 U2 2 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0016-5085 J9 GASTROENTEROLOGY JI Gastroenterology PD APR PY 1994 VL 106 IS 4 SU S BP A379 EP A379 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA NH909 UT WOS:A1994NH90901504 ER PT J AU CREMINS, J SALATA, K KIKENDALL, W HERSHEY, J NAIR, P WONG, RKH AF CREMINS, J SALATA, K KIKENDALL, W HERSHEY, J NAIR, P WONG, RKH TI COLONOCYTE EXPRESSION OF CD AND HLA MARKERS IN PATIENTS WITH NORMAL AND NEOPLASTIC COLONS SO GASTROENTEROLOGY LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,GASTROENTEROL SERV,WASHINGTON,DC 20307. USDA,LIPID NUTR LAB,BELTSVILLE,MD 20705. NR 0 TC 6 Z9 5 U1 2 U2 2 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0016-5085 J9 GASTROENTEROLOGY JI Gastroenterology PD APR PY 1994 VL 106 IS 4 SU S BP A379 EP A379 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA NH909 UT WOS:A1994NH90901505 ER PT J AU DELABAUME, HR KADAKIA, S SHAFFER, R AF DELABAUME, HR KADAKIA, S SHAFFER, R TI EFFECTS OF THE NICOTINE PATCH ON ESOPHAGEAL MOTILITY SO GASTROENTEROLOGY LA English DT Meeting Abstract C1 BROOKE ARMY MED CTR,DEPT MED,GASTROENTEROL SERV,FT SAM HOUSTON,TX 78234. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0016-5085 J9 GASTROENTEROLOGY JI Gastroenterology PD APR PY 1994 VL 106 IS 4 SU S BP A1047 EP A1047 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA NH909 UT WOS:A1994NH90904165 ER PT J AU KADAKIA, S KATZ, N AF KADAKIA, S KATZ, N TI PROSPECTIVE EVALUATION OF VARIOUS PARAMETERS AFTER PNEUMATIC DILATION IN PATIENTS WITH ACHALASIA SO GASTROENTEROLOGY LA English DT Meeting Abstract C1 BROOKE ARMY MED CTR,DEPT MED,GASTROENTEROL SERV,SAN ANTONIO,TX. BROOKE ARMY MED CTR,DEPT MED,NUCL MED SERV,SAN ANTONIO,TX. BROOKE ARMY MED CTR,DEPT RADIOL,GASTROENTEROL SERV,SAN ANTONIO,TX. BROOKE ARMY MED CTR,DEPT RADIOL,NUCL MED SERV,SAN ANTONIO,TX. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0016-5085 J9 GASTROENTEROLOGY JI Gastroenterology PD APR PY 1994 VL 106 IS 4 SU S BP A102 EP A102 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA NH909 UT WOS:A1994NH90900400 ER PT J AU KIKENDALL, JW MAGNETTI, C BURGESS, M STACEWICZSAPUNTZAKIS, M LANGENBERG, P BOWEN, PE AF KIKENDALL, JW MAGNETTI, C BURGESS, M STACEWICZSAPUNTZAKIS, M LANGENBERG, P BOWEN, PE TI VITAMIN-A NUTRITURE AND THE RISK OF COLONIC ADENOMAS SO GASTROENTEROLOGY LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,GASTROENTEROL SERV,WASHINGTON,DC 20307. UNIV ILLINOIS,DEPT NUTR & MED DIETET,CHICAGO,IL 60680. UNIV MARYLAND,DEPT EPIDEMIOL,BALTIMORE,MD 21201. NR 0 TC 1 Z9 1 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0016-5085 J9 GASTROENTEROLOGY JI Gastroenterology PD APR PY 1994 VL 106 IS 4 SU S BP A401 EP A401 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA NH909 UT WOS:A1994NH90901594 ER PT J AU MULLETT, C ACHESON, D TSENG, LY BOEDEKER, E AF MULLETT, C ACHESON, D TSENG, LY BOEDEKER, E TI HIGH-TITER SERUM ANTIBODY AGAINST THE B-SUBUNIT OF SHIGA-LIKE TOXIN-I PROTECTS IN A MODEL OF ENTEROHEMORRHAGIC ESCHERICHIA-COLI (EHEC) COLITIS SO GASTROENTEROLOGY LA English DT Meeting Abstract C1 USUHS,BETHESDA,MD. TUFTS UNIV NEW ENGLAND MED CTR,BOSTON,MA 02111. WALTER REED ARMY INST RES,WASHINGTON,DC 20307. NR 0 TC 4 Z9 4 U1 0 U2 1 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0016-5085 J9 GASTROENTEROLOGY JI Gastroenterology PD APR PY 1994 VL 106 IS 4 SU S BP A740 EP A740 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA NH909 UT WOS:A1994NH90902945 ER PT J AU RAIMONDI, F KAPER, JB WOLF, M BOEDEKER, EC FASANO, A AF RAIMONDI, F KAPER, JB WOLF, M BOEDEKER, EC FASANO, A TI RDEC-1 PRODUCES A NEW ENTEROTOXIN ACTIVE ON RABBIT ILEUM IN-VITRO SO GASTROENTEROLOGY LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,CTR VACCINE DEV,WASHINGTON,DC 20307. UNIV MARYLAND,SCH MED,DIV PEDIAT GASTROENTEROL & NUTR,BALTIMORE,MD 21201. WALTER REED ARMY INST RES,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0016-5085 J9 GASTROENTEROLOGY JI Gastroenterology PD APR PY 1994 VL 106 IS 4 SU S BP A263 EP A263 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA NH909 UT WOS:A1994NH90901041 ER PT J AU RAIMONDI, F KAPER, JB FASANO, A AF RAIMONDI, F KAPER, JB FASANO, A TI VIBRIO-PARAHAEMOLYTICUS THERMOSTABLE DIRECT HEMOLYSIN (TDH) INDUCES INTESTINAL SECRETION IN RABBIT ILEUM IN-VITRO SO GASTROENTEROLOGY LA English DT Meeting Abstract C1 UNIV MARYLAND,SCH MED,DIV PEDIAT GASTROENTEROL & NUTR,BALTIMORE,MD 21201. WALTER REED ARMY INST RES,CTR VACCINE DEV,WASHINGTON,DC 20307. NR 1 TC 0 Z9 0 U1 0 U2 1 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0016-5085 J9 GASTROENTEROLOGY JI Gastroenterology PD APR PY 1994 VL 106 IS 4 SU S BP A262 EP A262 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA NH909 UT WOS:A1994NH90901040 ER PT J AU SHAY, SS FALK, GW AF SHAY, SS FALK, GW TI REPETITIVE MANOMETRIC REFLUX EVENTS MAY IMPAIR ESOPHAGEAL MANOMETRY INTERPRETATION IN SOME PATIENTS WITH SEVERE GERD SO GASTROENTEROLOGY LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC. CLEVELAND CLIN,CLEVELAND,OH 44106. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0016-5085 J9 GASTROENTEROLOGY JI Gastroenterology PD APR PY 1994 VL 106 IS 4 SU S BP A177 EP A177 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA NH909 UT WOS:A1994NH90900703 ER PT J AU SHEAR, M CONNOR, BA SHLIM, DR TAYLOR, DN RABOLD, JG AF SHEAR, M CONNOR, BA SHLIM, DR TAYLOR, DN RABOLD, JG TI AZITHROMYCIN TREATMENT OF CYCLOSPORA INFECTIONS SO GASTROENTEROLOGY LA English DT Meeting Abstract C1 CIWEC CLIN,KATMANDU,NEPAL. CORNELL UNIV,MED CTR,NEW YORK HOSP,COLL MED,NEW YORK,NY 10021. WALTER REED ARMY INST RES,DEPT ENTER INFECT,WASHINGTON,DC 20307. NR 0 TC 2 Z9 2 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0016-5085 J9 GASTROENTEROLOGY JI Gastroenterology PD APR PY 1994 VL 106 IS 4 SU S BP A772 EP A772 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA NH909 UT WOS:A1994NH90903074 ER PT J AU SJOGREN, MH MACARTHY, P SEE, A PITTMAN, P AF SJOGREN, MH MACARTHY, P SEE, A PITTMAN, P TI RISK OF SEXUAL TRANSMISSION IN HEPATITIS-C VARIES WITH THE CLINICAL AND HISTOLOGICAL DIAGNOSIS OF SEXUAL CONTACT SO GASTROENTEROLOGY LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. WALTER REED ARMY INST RES,WASHINGTON,DC 20307. USAMRIID,FT DETRICK,MD. NR 0 TC 1 Z9 1 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0016-5085 J9 GASTROENTEROLOGY JI Gastroenterology PD APR PY 1994 VL 106 IS 4 SU S BP A988 EP A988 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA NH909 UT WOS:A1994NH90903929 ER PT J AU ZHANG, T STANLEY, SL ELSON, CO DERTZBAUGH, MT LI, E AF ZHANG, T STANLEY, SL ELSON, CO DERTZBAUGH, MT LI, E TI CONSTRUCTION OF A RECOMBINANT ORAL VACCINE TO PREVENT ENTAMOEBA-HISTOLYTICA INFECTION SO GASTROENTEROLOGY LA English DT Meeting Abstract C1 WASHINGTON UNIV,SCH MED,DEPT MOLEC MICROBIOL,ST LOUIS,MO 63110. WASHINGTON UNIV,SCH MED,DEPT BIOCHEM,ST LOUIS,MO 63110. WASHINGTON UNIV,SCH MED,DEPT MED,ST LOUIS,MO 63110. USA,MED RES INST INFECT DIS,FREDERICK,MD 21701. WASHINGTON UNIV,SCH MED,DEPT MOLEC BIOPHYS,ST LOUIS,MO 63110. UNIV ALABAMA,DEPT MED,BIRMINGHAM,AL 35294. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0016-5085 J9 GASTROENTEROLOGY JI Gastroenterology PD APR PY 1994 VL 106 IS 4 SU S BP A795 EP A795 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA NH909 UT WOS:A1994NH90903163 ER PT J AU BURRIS, HA FIELDS, SM AF BURRIS, HA FIELDS, SM TI TOPOISOMERASE-I INHIBITORS - AN OVERVIEW OF THE CAMPTOTHECIN ANALOGS SO HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA LA English DT Article ID CELL LUNG-CANCER; P-GLYCOPROTEIN EXPRESSION; PHASE-I; TOPOTECAN SK-AND-F-104864; BIOLOGICAL-ACTIVITY; CARCINOMA-CELLS; CPT-11; CHEMOTHERAPY; NSC-100880; RESISTANCE C1 UNIV TEXAS,HLTH SCI CTR,SAN ANTONIO,TX. BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234. CANC THERAPY & RES CTR S TEXAS,INVESTIGAT DRUG SECT,SAN ANTONIO,TX 78229. RP BURRIS, HA (reprint author), CANC THERAPY & RES CTR S TEXAS,INST DRUG DEV,8122 DATAPOINT DR,SUITE 650,SAN ANTONIO,TX 78229, USA. NR 94 TC 55 Z9 56 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0889-8588 J9 HEMATOL ONCOL CLIN N JI Hematol. Oncol. Clin. North Am. PD APR PY 1994 VL 8 IS 2 BP 333 EP 355 PG 23 WC Oncology; Hematology SC Oncology; Hematology GA NE754 UT WOS:A1994NE75400007 PM 8040144 ER PT J AU LI, YL LIU, CH AF LI, YL LIU, CH TI SIMPLIFIED GREEN-FUNCTIONS FOR CALCULATING CAPACITANCE AND INDUCTANCE OF MULTICONDUCTOR TRANSMISSION-LINES IN MULTILAYERED MEDIA SO IEE PROCEEDINGS-MICROWAVES ANTENNAS AND PROPAGATION LA English DT Note DE GREEN FUNCTIONS; TRANSMISSION LINES AB Using the impedance formula and the asymptotic property of the hyperbolic tangent function, the Green's function due to a line source embedded in a general layered medium has been analytically converted into a more suitable form for numerical calculation of capacitance and inductance. The new form is designed to eliminate slow convergence when the vertical distance of the source and field points is small. Another simplified Green's function for the layered medium shielded by two rectangular outer conductors is also given. Numerical results are compared with published data. The agreement is excellent. C1 USA,CONSTRUCT ENGN RES LAB,CHAMPAIGN,IL 61826. RP LI, YL (reprint author), UNIV ILLINOIS,DEPT ELECT & COMP ENGN,WAVE PROPAGAT LAB,3RD FLOOR N CSRL,1308 W MAIN ST,URBANA,IL 61801, USA. NR 14 TC 3 Z9 3 U1 0 U2 0 PU IEE-INST ELEC ENG PI HERTFORD PA MICHAEL FARADAY HOUSE SIX HILLS WAY STEVENAGE, HERTFORD, ENGLAND SG1 2AY SN 1350-2417 J9 IEE P-MICROW ANTEN P JI IEE Proc.-Microw. Antennas Propag. PD APR PY 1994 VL 141 IS 2 BP 141 EP 144 DI 10.1049/ip-map:19941028 PG 4 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA PA300 UT WOS:A1994PA30000013 ER PT J AU BUCHWALD, WR ZHAO, JH ZHU, LD SCHAUER, S JONES, KA AF BUCHWALD, WR ZHAO, JH ZHU, LD SCHAUER, S JONES, KA TI A 3-TERMINAL INP/INGAASP OPTOELECTRONIC THYRISTOR SO IEEE TRANSACTIONS ON ELECTRON DEVICES LA English DT Note ID SWITCH AB A three terminal light emitting opto-thyristor based on InP/InGaAsP heterostructures grown by liquid phase epitaxy (LPE) has been demonstrated. The opto-thyristor essentially combines the conventional PNPN thyristor and the NpN double heterostructure laser structure into a single PNpN device. Current-Voltage characteristics confirm the thyristor type switching action with a maximum gate controllable breakover voltage of 8 V. Substantially increased light output at wavelengths of 1.3 and 0.93 mum is observed upon switching. The optical output as a function of device voltage is also reported. C1 USA,RES LAB,EPS DIRECTORATE,FT MONMOUTH,NJ 07703. RP BUCHWALD, WR (reprint author), RUTGERS STATE UNIV,DEPT ELECT & COMP ENGN,PISCATAWAY,NJ 08855, USA. NR 11 TC 3 Z9 3 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9383 J9 IEEE T ELECTRON DEV JI IEEE Trans. Electron Devices PD APR PY 1994 VL 41 IS 4 BP 620 EP 622 DI 10.1109/16.278522 PG 3 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA NG441 UT WOS:A1994NG44100026 ER PT J AU TRAUTMANN, M VOGT, K HAMMACK, C CROSS, AS AF TRAUTMANN, M VOGT, K HAMMACK, C CROSS, AS TI A MURINE MONOCLONAL-ANTIBODY DEFINES A UNIQUE EPITOPE SHARED BY KLEBSIELLA LIPOPOLYSACCHARIDES SO INFECTION AND IMMUNITY LA English DT Article ID PNEUMONIAE; ANTIGEN; BACTEREMIA; POLYSACCHARIDES; ENDOTOXEMIA; CHLAMYDIA; SEROTYPES; INFECTION; LOCATION; STRAINS AB A hybridoma secreting a monoclonal antibody (MAb) directed against Klebsiella lipopolysaccharide (LPS) was derived from spleen cells of mice immunized with a smooth, nonencapsulated Klebsiella strain (Friedlander 201; serogroup 01). The MAb, called V/9-5 (immunoglobulin G2a), cross-reacted,vith LPS preparations produced from reference strains for the Klebsiella 0 serogroups 01, 02ab, 02ac, 03, 04, 05, and 012. Furthermore, the MAb reacted with LPSs from serogroup reference strains 06/08, 09, and 011, which are regarded as being identical to 01, 02, and 04, respectively. When testing the supernatant of clinically isolated Klebsiella strains by means of an inhibition enzyme-linked immunosorbent assay, we found that 86 (92.4%) of 93 Klebsiella pneumoniae subsp. pneumoniae isolates and 26 (96.0%) of 25 K. oxytoca isolates harbored the cross-reactive epitope. By contrast, two laboratory strains of K. pneumoniae subsp. rhinoscleromatis did not react with MAb V/9-5. The MAb proved to be specific for the genus Klebsiella, since it did not react with any of a total of 73 strains belonging to other gram-negative bacterial genera. In conjunction with other LPS-specific MAbs, MAb V/9-5 might become a useful reagent for rapid identification of klebsiellae in clinical specimens. Furthermore, the epitope recognized by MAb V/9-5 might serve as a target epitope for the production of human MAbs for immunotherapeutic purposes. C1 UNIV ULM,INST MICROBIOL,D-89070 ULM,GERMANY. FREE UNIV BERLIN,INST MED MICROBIOL,D-12203 BERLIN,GERMANY. RP TRAUTMANN, M (reprint author), WALTER REED ARMY MED CTR,DEPT BACTERIAL DIS,WASHINGTON,DC 20307, USA. NR 54 TC 16 Z9 16 U1 0 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD APR PY 1994 VL 62 IS 4 BP 1282 EP 1288 PG 7 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA NC074 UT WOS:A1994NC07400022 PM 7510667 ER PT J AU STOCK, RJ ZAINO, R BUNDY, BN ASKIN, FB WOODWARD, J FETTER, B PAULSON, JA DISAIA, PJ STEHMAN, FB AF STOCK, RJ ZAINO, R BUNDY, BN ASKIN, FB WOODWARD, J FETTER, B PAULSON, JA DISAIA, PJ STEHMAN, FB TI EVALUATION AND COMPARISON OF HISTOPATHOLOGIC GRADING SYSTEMS OF EPITHELIAL CARCINOMA OF THE UTERINE CERVIX - GYNECOLOGIC-ONCOLOGY-GROUP STUDIES SO INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY LA English DT Article DE HISTOLOGIC CLASSIFICATION; HISTOPATHOLOGIC GRADING SYSTEMS; ADVANCED CARCINOMA UTERINE CERVIX; STENDAHL SCORING SYSTEM; REAGAN-WENTZ CELL TYPE ID SQUAMOUS-CELL CARCINOMA; HISTOLOGIC CLASSIFICATION; RADIATION-THERAPY; CANCER; PROGNOSIS; HYDROXYUREA; SURVIVAL AB The subjects of this study are 445 patients with advanced cervical cancer treated by standardized radiation therapy. Upon entry into one of two Gynecologic Oncology Group (GOG) protocols, original pathologic diagnoses and histologic tumor descriptions for each patient were compared with separate evaluations made by a consensus opinion of two GOG pathologists. A review diagnosis using grade, cell type, and the Stendahl scoring system was then made by the first author (R.J.S.) without knowledge of the prior diagnoses. Of the original pathologists' diagnoses, 21% did not include grade or cell type. There was little agreement among the different pathologists as to the use of either specific grade or cell type. Histologic grade, ir-respective of the pathologists making the diagnosis, had no correlation to prognosis. The Reagan and Wentz large-cell keratinizing (LCK) cell type, when applied by the author to tumors with any form of squamous keratinization present, identified a group of patients with a poorer prognosis, although not independently of other prognostic factors. The Stendahl scoring system identified a number of patients with both a poorer and better prognosis. This was statistically significant and independent of other risk factors. A major limitation, however, was the number of patients evaluable because of inadequate biopsy material in 23.6% of the study group. C1 USN,DEPT OBSTET & GYNECOL & ANAT PATHOL,PORTSMOUTH,VA 23708. PENN STATE UNIV,MILTON S HERSHEY MED CTR,DEPT PATHOL,HERSHEY,PA 17033. NEW YORK STATE DEPT HLTH,ROSWELL PK MEM INST,GYNECOL ONCOL GRP,BUFFALO,NY 14263. JOHNS HOPKINS UNIV HOSP,DEPT SURG PATHOL,BALTIMORE,MD 21205. WALTER REED ARMY MED CTR,DEPT ANAT PATHOL,WASHINGTON,DC. UNIFORMED SERV UNIV HLTH SCI,DEPT PATHOL,BETHESDA,MD 20814. DUKE UNIV,MED CTR,DURHAM,NC 27710. COOPER HOSP UNIV MED CTR,CAMDEN,NJ. UNIV CALIF IRVINE,IRVINE CANC CTR,DEPT OBSTET & GYNECOL,IRVINE,CA 92717. INDIANA UNIV,MED CTR,DEPT OBSTET & GYNECOL,INDIANAPOLIS,IN 46204. FU NCI NIH HHS [CA 12484, CA 12534, CA 27816] NR 25 TC 12 Z9 13 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0277-1691 J9 INT J GYNECOL PATHOL JI Int. J. Gynecol. Pathol. PD APR PY 1994 VL 13 IS 2 BP 99 EP 108 DI 10.1097/00004347-199404000-00001 PG 10 WC Obstetrics & Gynecology; Pathology SC Obstetrics & Gynecology; Pathology GA NB461 UT WOS:A1994NB46100001 PM 8005742 ER PT J AU KIM, HJ HAERING, C AF KIM, HJ HAERING, C TI EVALUATION OF PROTEIN CROSS-LINKING AND BIODEGRADABILITY BY DETERMINATION OF TRYPTOPHAN RELEASED BY PRONASE USING REVERSED-PHASE HPLC WITH PHOTODIODE-ARRAY DETECTION SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY LA English DT Article ID PERFORMANCE LIQUID-CHROMATOGRAPHY; AROMATIC-AMINO-ACIDS; QUANTITATION; PEPTIDES AB A bioanalytical method for evaluating the extent of protein cross-linking was developed. The method is based on reversed-phase HPLC determination of tryptophan released from the cross-linked proteins by Pronase, a nonspecific proteolytic enzyme. The amounts of tryptophan released from un-cross-linked bovine serum albumin (BSA), a nanopeptide, and Trp-Phe in control experiments were consistent with the tryptophan content of the protein and peptides. However, the amount of tryptophan released decreased significantly when BSA was cross-linked extensively by heating at 120 degrees C in the presence of glucose. The decrease in tryptophan showed a good correlation with the amount of cross-linked BSA that remained insoluble after Pronase digestion, suggesting that tryptophan released by Pronase is a useful measure of the cross-linking and biodegradability of a protein-based biomaterial. C1 FRAMINGHAM HIGH SCH,FRAMINGHAM,MA 01701. RP KIM, HJ (reprint author), USA,NATICK RES DEV & ENGN CTR,NATICK,MA 01760, USA. NR 16 TC 1 Z9 1 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0021-8561 J9 J AGR FOOD CHEM JI J. Agric. Food Chem. PD APR PY 1994 VL 42 IS 4 BP 915 EP 918 DI 10.1021/jf00040a015 PG 4 WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science & Technology SC Agriculture; Chemistry; Food Science & Technology GA NH286 UT WOS:A1994NH28600015 ER PT J AU HOYT, RW KNAPIK, JJ LANZA, JF JONES, BH STAAB, JS AF HOYT, RW KNAPIK, JJ LANZA, JF JONES, BH STAAB, JS TI AMBULATORY FOOT CONTACT MONITOR TO ESTIMATE METABOLIC COST OF HUMAN LOCOMOTION SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE WALKING; RUNNING; ACTIVITY MONITORING; ENERGY EXPENDITURE; OXYGEN UPTAKE; EXERCISE; EXERTION ID ENERGY-EXPENDITURE; PHYSICAL-ACTIVITY; HEART-RATE; EXERCISE; HEALTH; ACCELEROMETER; CALORIMETRY; INJURIES; CHILDREN; DISEASE AB The rate of metabolic energy expenditure during locomotion (M(loco)) is propertional to body weight (W-b) divided by the time during each stride that a single foot contacts the ground (t(c)) (Nature Lond. 346: 265-267, 1990). Using this knowledge, we developed an electronic foot contact monitor. Our objective was to derive and cross-validate an equation for estimating M(loco) from W-b/t(c). Twelve males were tested [age = 19.4 +/- 1.4 (SD) yr, W-b = 78.4 +/- 8.0 kg] during horizontal treadmill walking (0.89, 1.34, and 1.79 m/s) and running (2.46, 2.91, and 3.35 m/s). Measured M(loco) was defined as the total rate of energy expenditure, measured by indirect calorimetry, minus the estimated rate of resting energy expenditure. The equation to estimate M(loco) was derived in six randomly selected subjects: M(loco) = 3.702.(W-b/t(c)) -149.6 (r(2) = 0.93). Cross-validation in the remaining six subjects showed that estimated and measured M(loco) were highly correlated (r(2) = 0.97). The average individual error between estimated and measured M(loco) was 0% (range -22 to 29%). In conclusion, M(loco) can be accurately estimated from W-b and measurements of t(c) made by an ambulatory foot contact monitor. C1 USA,NATICK RES DEV & ENGN CTR,NATICK,MA 01760. RP HOYT, RW (reprint author), USA,ENVIRONM MED RES INST,DIV ALTITUDE PHYSIOL & MED,NATICK,MA 01760, USA. NR 24 TC 24 Z9 24 U1 0 U2 4 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 8750-7587 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD APR PY 1994 VL 76 IS 4 BP 1818 EP 1822 PG 5 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA NG707 UT WOS:A1994NG70700058 PM 8045864 ER PT J AU HOGAN, AW AF HOGAN, AW TI OBJECTIVE ESTIMATES OF AIRBORNE SNOW PROPERTIES SO JOURNAL OF ATMOSPHERIC AND OCEANIC TECHNOLOGY LA English DT Article AB A mensuration and description method is proposed that allows objective and simultaneous expression of the physical properties of snow crystals, rime drops, and aerosol particles. It is based on the statistics of Hatch and Choate, which are commonly used to describe ''dusts'' and supermicrometer aerosol particles with irregular shape. These statistics simplify integration of physical properties of snowflakes over their diameter distribution and facilitate expression of simultaneous formulas that can be used to calculate the contribution of riming to airborne snow mass and the contribution of rime nuclei to airborne snow chemistry. These formulated expressions are combined with tabulations of size properties of snowflakes, cloud droplets, and aerosol to provide the skeleton of a calculation program. These calculations can transform the area, mass, or number concentration of snow fluxes into other parameters when one flux parameter and the snow-crystal habit are specified. Other size-dependent parameters are easily inserted in this skeleton to facilitate estimation of physical properties of suspended snow. The cross-sectional area-to-mass ratio of airborne snow, with respect to the distribution of particle diameters, is relatively large when compared to liquid precipitation particles. The cross-sectional area-to-mass ratio provides an objective parameter for comparison of snowflake properties with respect to crystal type. Several figures are presented that show the variation of airborne snow area, mass contribution by rime, and snow chemistry as a function of crystal type and diameter distribution. RP HOGAN, AW (reprint author), USA,DEPT ARMY,COLD REG RES & ENGN LAB,DIV RES,GEOCHEM SCI BRANCH,HANOVER,NH 03755, USA. NR 0 TC 9 Z9 9 U1 0 U2 0 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 SN 0739-0572 J9 J ATMOS OCEAN TECH JI J. Atmos. Ocean. Technol. PD APR PY 1994 VL 11 IS 2 BP 432 EP 444 DI 10.1175/1520-0426(1994)011<0432:OEOASP>2.0.CO;2 PN 2 PG 13 WC Engineering, Ocean; Meteorology & Atmospheric Sciences SC Engineering; Meteorology & Atmospheric Sciences GA NE049 UT WOS:A1994NE04900002 ER PT J AU YAMAGA, KM KIMURA, LH PLYMYER, MR GLANT, TT LANCE, EM AF YAMAGA, KM KIMURA, LH PLYMYER, MR GLANT, TT LANCE, EM TI DIFFERENTIATION ANTIGENS OF HUMAN ARTICULAR CHONDROCYTES AND THEIR TISSUE DISTRIBUTION AS ASSESSED BY MONOCLONAL-ANTIBODIES SO JOURNAL OF AUTOIMMUNITY LA English DT Article ID S-100 PROTEIN; CARTILAGE; PROTEOGLYCAN; SULFATE; INHIBITION; EPITOPES; CULTURE; CELLS; RAT C1 UNIV HAWAII,SHRINERS HOSP CRIPPLED CHILDREN,HONOLULU UNIT,HONOLULU,HI. TRIPLER ARMY MED CTR,HONOLULU,HI 96859. RUSH PRESBYTERIAN ST LUKES MED CTR,DEPT BIOCHEM,CHICAGO,IL 60612. RUSH PRESBYTERIAN ST LUKES MED CTR,DEPT ORTHOPED SURG,CHICAGO,IL 60612. RP YAMAGA, KM (reprint author), UNIV HAWAII,JOHN A BURNS SCH MED,DEPT TROP MED & MED IMMUNOL,36 KILAUEA AVE,HONOLULU,HI 96816, USA. FU NIAMS NIH HHS [R01 AR 40310] NR 25 TC 7 Z9 7 U1 0 U2 1 PU ACADEMIC PRESS LTD PI LONDON PA 24-28 OVAL RD, LONDON, ENGLAND NW1 7DX SN 0896-8411 J9 J AUTOIMMUN JI J. Autoimmun. PD APR PY 1994 VL 7 IS 2 BP 203 EP 217 DI 10.1006/jaut.1994.1016 PG 15 WC Immunology SC Immunology GA NH863 UT WOS:A1994NH86300006 PM 8037839 ER PT J AU NICKOLAISEN, SL VENEY, DW CARTLAND, HE AF NICKOLAISEN, SL VENEY, DW CARTLAND, HE TI CO(V,J) PRODUCT STATE DISTRIBUTIONS FROM THE REACTION O(3P)+OCS-]CO+SO SO JOURNAL OF CHEMICAL PHYSICS LA English DT Article ID EXCIMER LASER PHOTOLYSIS; EXCITATION; ATOMS; CO2; OCS; COLLISIONS; PROBE AB The title reaction was studied by probing CO[upsilon,J] product state distributions with a tunable infrared diode laser. Only the fastest O(3P) atoms formed by 355 nm photolysis of NO2, i.e., Those corresponding to NO[2PI1/2, upsilon = 0], have sufficient energy to surmount the activation barrier. Thus these experiments were performed under monoenergetic, near-threshold conditions. The CO[upsilon,J] distributions were extracted from the relative slopes of the transient infrared absorption signals. Little vibrational excitation is observed. The vibrational branching ratio is [upsilon=1]/[upsilon=0]almost-equal-to 0.05; CO[upsilon greater-than-or-equal-to 21 was not detected. In contrast, rotational degrees of freedom are much hotter. The nascent CO[upsilon = 0] rotational distribution is well characterized by a temperature of T(R)=4400+/-390 K. Total CO internal excitation, on the average 3150 cm-1, accounts for 16% of the energy available to products. Surprisal analyses based on several models of energy disposal show that the nascent distributions are nonstatistically cold. The results are consistent with direct attack at the S atom to firm an OSCO intermediate, followed by rapid C-S bond scission which exerts a torque on the CO product. C1 US MIL ACAD,PHOTON RES CTR,W POINT,NY 10996. NR 24 TC 5 Z9 5 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-9606 J9 J CHEM PHYS JI J. Chem. Phys. PD APR 1 PY 1994 VL 100 IS 7 BP 4925 EP 4931 DI 10.1063/1.467278 PG 7 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA ND254 UT WOS:A1994ND25400022 ER PT J AU LAW, WA MARTIN, A MAPOU, RL ROLLER, TL SALAZAR, AM TEMOSHOK, LR RUNDELL, JR AF LAW, WA MARTIN, A MAPOU, RL ROLLER, TL SALAZAR, AM TEMOSHOK, LR RUNDELL, JR TI WORKING-MEMORY IN INDIVIDUALS WITH HIV-INFECTION SO JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY LA English DT Article; Proceedings Paper CT 1st International Conference on the Biopsychosocial Aspects of HIV Infection CY AUG, 1991 CL AMSTERDAM, NETHERLANDS ID IMMUNODEFICIENCY-VIRUS-INFECTION; AIDS DEMENTIA COMPLEX; REACTION-TIME AB The central executive component (CE) of Baddeley's working memory model (Baddeley, 1992) was evaluated in 26 asymptomatic human immunodeficiency virus-infected individuals (HIV+) and 23 HIV-control subjects using a dual-task working memory paradigm. The HIV+ and HIV- groups showed an equivalent reduction in performance on both the primary task (visual vigilance) and the secondary task (letter span) when they were performed concurrently relative to when either task was performed alone. This result suggested normal CE functioning in these HIV+ subjects. In contrast, the HIV+ subjects had significantly longer response latencies on reaction time measures relative to the HIV- control group. These findings indicated that slowed processing in early stage HIV-infected individuals is not associated with a working memory deficit. C1 HENRY M JACKSON FDN ADV MIL MED,ROCKVILLE,MD. NIMH,CLIN SCI LAB,BETHESDA,MD 20892. UNIFORMED SERV UNIV HLTH SCI,DEPT NEUROL,BETHESDA,MD 20814. WALTER REED ARMY INST RES,WASHINGTON,DC. RI martin, alex/B-6176-2009 NR 28 TC 35 Z9 38 U1 0 U2 1 PU SWETS ZEITLINGER PUBLISHERS PI LISSE PA P O BOX 825, 2160 SZ LISSE, NETHERLANDS SN 1380-3395 J9 J CLIN EXP NEUROPSYC JI J. Clin. Exp. Neuropsychol. PD APR PY 1994 VL 16 IS 2 BP 173 EP 182 DI 10.1080/01688639408402628 PG 10 WC Psychology, Clinical; Clinical Neurology; Psychology SC Psychology; Neurosciences & Neurology GA NG556 UT WOS:A1994NG55600002 PM 8021304 ER PT J AU LABBATE, LA SACHS, GS AF LABBATE, LA SACHS, GS TI PHOTOTHERAPY-INDUCED HOT FLUSHES SO JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY LA English DT Letter C1 MASSACHUSETTS GEN HOSP,CLIN PSYCHOPHARMACOL UNIT,BOSTON,MA 02114. RP LABBATE, LA (reprint author), WALTER REED ARMY MED CTR,DEPT PSYCHIAT,WASHINGTON,DC 20307, USA. NR 5 TC 2 Z9 2 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0271-0749 J9 J CLIN PSYCHOPHARM JI J. Clin. Psychopharmacol. PD APR PY 1994 VL 14 IS 2 BP 151 EP 151 DI 10.1097/00004714-199404000-00015 PG 1 WC Pharmacology & Pharmacy; Psychiatry SC Pharmacology & Pharmacy; Psychiatry GA NC590 UT WOS:A1994NC59000015 PM 8195461 ER PT J AU JOHNSON, WS OBRIEN, TK MASTERS, JE AF JOHNSON, WS OBRIEN, TK MASTERS, JE TI STINCHCOMB,WAYNE,W. - IN-MEMORIAM SO JOURNAL OF COMPOSITES TECHNOLOGY & RESEARCH LA English DT Item About an Individual C1 LOCKHEED ENGN & SCI,HAMPTON,VA 23666. USA,VEHICLE STRUCT DIRECTORATE,HAMPTON,VA 23681. RP JOHNSON, WS (reprint author), NASA,LANGLEY RES CTR,NS 188E,HAMPTON,VA 23681, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TESTING MATERIALS PI W CONSHOHOCKEN PA 100 BARR HARBOR DR, W CONSHOHOCKEN, PA 19428-2959 SN 0884-6804 J9 J COMPOS TECH RES JI J. Compos. Technol. Res. PD APR PY 1994 VL 16 IS 2 BP 101 EP 101 PG 1 WC Materials Science, Composites; Polymer Science SC Materials Science; Polymer Science GA NF977 UT WOS:A1994NF97700001 ER PT J AU ZALAMEDA, JN FARLEY, GL SMITH, BT AF ZALAMEDA, JN FARLEY, GL SMITH, BT TI A FIELD DEPLOYABLE NONDESTRUCTIVE IMPACT DAMAGE ASSESSMENT METHODOLOGY FOR COMPOSITE STRUCTURES SO JOURNAL OF COMPOSITES TECHNOLOGY & RESEARCH LA English DT Article DE THROUGH-THE-THICKNESS (TTT) REINFORCEMENT; THERMAL NONDESTRUCTIVE EVALUATION (NDE); ULTRASONIC VOLUMETRIC IMAGING; COMPOSITES AB A technique is being developed for rapid in-service detection and quantification of damage in composite airframe structures combining thermal and ultrasonic nondestructive evaluation (NDE). Thermal inspection techniques can be used to identify impact damage areas because it is fast, inspects large areas, and is noncontacting. Once an area of concern is identified, characterization of the depth and extent of the damage can be determined using ultrasonic volumetric imaging. Ultrasonic volumetric imaging quantifies the damage by giving a ply-by-ply view of the damage. Single-sided measurements were made on two types of samples, flat panels with through-the-thickness reinforcements and a ''Y''-stiffened skin. These samples were impacted with an aluminum ball at various velocities. The thermal results were compared with ultrasonic C-scans and the ultrasonic volumetric results were compared with destructive tests. The thermal images compared well with the C-scan images in both relative size and shape. It was found that the ultrasonic volumetric results gave a better indication of damage than achievable with the destructive specimen evaluation method. It has been shown that a multidisciplinary approach using thermal and ultrasonic NDE techniques is an efficient and informative inspection method for identifying and quantifying damage. C1 COLL WILLIAM & MARY,WILLIAMSBURG,VA 23185. RP ZALAMEDA, JN (reprint author), USA,RES LAB,VEHICLE STRUCT DIRECTORATE,NASA,LANGLEY RES CTR,HAMPTON,VA 23681, USA. NR 10 TC 2 Z9 3 U1 1 U2 2 PU AMER SOC TESTING MATERIALS PI W CONSHOHOCKEN PA 100 BARR HARBOR DR, W CONSHOHOCKEN, PA 19428-2959 SN 0884-6804 J9 J COMPOS TECH RES JI J. Compos. Technol. Res. PD APR PY 1994 VL 16 IS 2 BP 161 EP 169 PG 9 WC Materials Science, Composites; Polymer Science SC Materials Science; Polymer Science GA NF977 UT WOS:A1994NF97700008 ER PT J AU DAI, WL WOODWARD, PR AF DAI, WL WOODWARD, PR TI AN APPROXIMATE RIEMANN SOLVER FOR IDEAL MAGNETOHYDRODYNAMICS SO JOURNAL OF COMPUTATIONAL PHYSICS LA English DT Article ID HYPERBOLIC CONSERVATION-LAWS; MHD INTERMEDIATE SHOCKS; NONOSCILLATORY SCHEMES; ORDER; EQUATIONS AB To construct numerical schemes of he Godunov type for solving magnetohydrodynamical (MHD) problems, an approximate method of solving the MHD Riemann problem is required in order to calculate the time-averaged fluxes at the interfaces of numerical zones, Such an MHD Riemann solver is presented here which treats all waves emanating from the initial discontinuity as themselves discontinuous. Thus shock jump conditions are used for rarefactions, which limits the applicability of this work to weak rarefactions, the case most important for computation. The solutions from our approximate MHD Riamnn solver consist of two fast waves (either shock or rarefaction) two rotational discontinuities, two rarefaction waves (either shock or rarefaction), and one contact discontinuity for a general MHD Riemann problem. In order to display rotational discontinuities, a three-component model is necessary. Only under very limited circumstances is there no rotational discontinuity involved and thus the two component approximation may be used in the MHD Riemann problem. The solutions of the MHD Riemann problem in the shock tube problem which generates the compound wave in the earlier work contain two fast rarefaction waves, two slow shocks, one contact discontinuity, and one rotational discontinuity in our formalism. (C) 1994 Academic Press, Inc. RP UNIV MINNESOTA, SCH PHYS & ASTRON, INST SUPERCOMP, ARMY HIGH PERFORMANCE COMP RES CTR, MINNEAPOLIS, MN 55415 USA. NR 28 TC 89 Z9 90 U1 0 U2 2 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0021-9991 EI 1090-2716 J9 J COMPUT PHYS JI J. Comput. Phys. PD APR PY 1994 VL 111 IS 2 BP 354 EP 372 DI 10.1006/jcph.1994.1069 PG 19 WC Computer Science, Interdisciplinary Applications; Physics, Mathematical SC Computer Science; Physics GA NK226 UT WOS:A1994NK22600014 ER PT J AU WARNER, JW GATES, TK NAMVARGOLIAN, R MILLER, P COMES, G AF WARNER, JW GATES, TK NAMVARGOLIAN, R MILLER, P COMES, G TI SEDIMENT AND MICROBIAL FOULING OF EXPERIMENTAL GROUNDWATER RECHARGE TRENCHES SO JOURNAL OF CONTAMINANT HYDROLOGY LA English DT Article ID SATURATED HYDRAULIC CONDUCTIVITY; SAND COLUMNS AB A common method of recharging groundwater is by the use of injection wells and/or recharge trenches. With time the recharge capacities of the wells/trenches progressively decline. Deposition of suspended fines in the recharge water and growth of microorganisms in the aquifer are common causes of this decline. This paper presents an investigation of the relative significance of these two factors under controlled laboratory conditions. Large-scale physical models of recharge trenches were constructed in the laboratory to monitor the decline with time of the recharge capacity under controlled conditions. The physical models consisted of four hydraulically separate cells in which six different experiments were conducted. In three of the experiments microorganisms were added as an inoculant. A nutrient and carbon fine solution was constantly injected into the influent stream entering through the inflow pipe. Both carbon fines and microorganisms caused plugging of the model recharge trenches in the laboratory. However, initially the microbes appeared to have a beneficial effect by hindering the transport of the carbon fines from the gravel pack in the trench. Later the microbes contributed to the plugging of the gravel pack. A significant correlation was determined between the extent of carbon fine deposition and microbial growth. In the experiment using a biodegradable slurry, microbial growth did not affect the recharge capacity of the trench. One laboratory experiment involved the introduction of silt as a source of sediment fines to the model recharge trench. This experiment simulated conditions often found in the field when no carbon fine adsorption system is used and natural surface water is recharged into the aquifer. This research will be useful in understanding the relative importance of factors contributing to the decline of recharge capacity observed in the field. C1 USA,CORPS ENGINEERS,WATERWAYS EXPT STN,VICKSBURG,MS 39181. RP WARNER, JW (reprint author), COLORADO STATE UNIV,DEPT CIVIL ENGN,FT COLLINS,CO 80523, USA. NR 12 TC 5 Z9 5 U1 2 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0169-7722 J9 J CONTAM HYDROL JI J. Contam. Hydrol. PD APR PY 1994 VL 15 IS 4 BP 321 EP 344 DI 10.1016/0169-7722(94)90033-7 PG 24 WC Environmental Sciences; Geosciences, Multidisciplinary; Water Resources SC Environmental Sciences & Ecology; Geology; Water Resources GA NH900 UT WOS:A1994NH90000005 ER PT J AU TRUMBULL, VL DUBOIS, PC BROZKA, RJ GUYETTE, R AF TRUMBULL, VL DUBOIS, PC BROZKA, RJ GUYETTE, R TI MILITARY CAMPING IMPACTS ON VEGETATION AND SOILS OF THE OZARK PLATEAU SO JOURNAL OF ENVIRONMENTAL MANAGEMENT LA English DT Article DE MECHANIZED EQUIPMENT; FOOT TRAFFIC; SOIL COMPACTION; SOIL BULK DENSITY; INFILTRATION; SOIL ORGANIC CARBON; DENDROCHRONOLOGY; FOREST LITTER ID DESERT; INFILTRATION; COMPACTION; PONDEROSA; GROWTH; PINE C1 UNIV ILLINOIS, DEPT ECOL ETHOL & EVOLUT, URBANA, IL 61801 USA. USA, CORPS ENGINEERS, CONSTRUCT ENGN RES LABS, CHAMPAIGN, IL 61826 USA. COLORADO STATE UNIV, DEPT FOREST SCI, CTR ECOL MANAGEMENT MIL LANDS, FT COLLINS, CO 80523 USA. UNIV MISSOURI, SCH FORESTRY FISHERIES & WILDLIFE, COLUMBIA, MO 65211 USA. RP TRUMBULL, VL (reprint author), UNIV ILLINOIS, INST ENVIRONM STUDIES, URBANA, IL 61801 USA. NR 39 TC 19 Z9 22 U1 0 U2 5 PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD PI LONDON PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND SN 0301-4797 EI 1095-8630 J9 J ENVIRON MANAGE JI J. Environ. Manage. PD APR PY 1994 VL 40 IS 4 BP 329 EP 339 DI 10.1006/jema.1994.1026 PG 11 WC Environmental Sciences SC Environmental Sciences & Ecology GA NK185 UT WOS:A1994NK18500004 ER PT J AU MUNAVALLI, S MULLER, AJ ROSSMAN, DI ROHRBAUGH, DK FERGUSON, CP AF MUNAVALLI, S MULLER, AJ ROSSMAN, DI ROHRBAUGH, DK FERGUSON, CP TI SYNTHESIS OF BIS(TRIFLUOROMETHYL)TRISULFIDE AND BIS(TRIFLUOROMETHYLTHIO)SELENIDE SO JOURNAL OF FLUORINE CHEMISTRY LA English DT Article ID S-S BONDS; GRIGNARD-REAGENTS; C-S AB The use of 4-dimethylaminopyridine as a catalyst in the reaction of trifluoromethylsulfenyl chloride with hydrogen sulfide at -78-degrees-C cuts down the time of reaction from 30 d to 1 d and gives up to 70% yield of bis(trifluoromethyl)trisulfide (1). Similarly, bis(trifluorometbylthio)selenide (2) can be prepared from hydrogen selenide and trifluoromethylsulfenyl chloride. The influence of other catalysts on the course of the reaction, the formation of unusual by-products, the NMR and mass spectral data of 1 and 2 are presented in this paper. C1 USA,EDGEWOOD RES DEV & ENGN CTR,ABERDEEN PROVING GROUND,MD 21010. RP MUNAVALLI, S (reprint author), GEO CENTERS INC,FT WASHINGTON,MD 20774, USA. NR 14 TC 11 Z9 11 U1 0 U2 0 PU ELSEVIER SCIENCE SA LAUSANNE PI LAUSANNE 1 PA PO BOX 564, 1001 LAUSANNE 1, SWITZERLAND SN 0022-1139 J9 J FLUORINE CHEM JI J. Fluor. Chem. PD APR PY 1994 VL 67 IS 1 BP 37 EP 40 DI 10.1016/0022-1139(93)02928-8 PG 4 WC Chemistry, Inorganic & Nuclear; Chemistry, Organic SC Chemistry GA ND180 UT WOS:A1994ND18000010 ER PT J AU SMITH, KJ SKELTON, H LEDSKY, R NG, TH YEAGER, J WAGNER, K AF SMITH, KJ SKELTON, H LEDSKY, R NG, TH YEAGER, J WAGNER, K TI INCREASED DRUG-REACTIONS IN HIV-1+ PATIENTS - A POSSIBLE EXPLANATION-BASED ON PATTERNS OF IMMUNE DYSREGULATION SO JOURNAL OF INVESTIGATIVE DERMATOLOGY LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,WASHINGTON,DC 20307. ARMED FORCES INST PATHOL,BETHESDA,MD. USN,NATL MED CTR,DEPT DERMATOL,BETHESDA,MD. HENRY M JACKSON FDN,BETHESDA,MD. NR 0 TC 0 Z9 0 U1 0 U2 0 PU BLACKWELL SCIENCE INC PI CAMBRIDGE PA 238 MAIN ST, CAMBRIDGE, MA 02142 SN 0022-202X J9 J INVEST DERMATOL JI J. Invest. Dermatol. PD APR PY 1994 VL 102 IS 4 BP 543 EP 543 PG 1 WC Dermatology SC Dermatology GA NF406 UT WOS:A1994NF40600143 ER PT J AU SKELTON, HG SMITH, KJ CHU, WS YEAGER, J WAGNER, K AF SKELTON, HG SMITH, KJ CHU, WS YEAGER, J WAGNER, K TI LYMPHOID MARKERS, ACTIVATION MARKERS, AND ADHESION MOLECULES ON CUTANEOUS BIOPSIES FROM HIV-1+ PATIENTS WITH DISEASE PROGRESSION SO JOURNAL OF INVESTIGATIVE DERMATOLOGY LA English DT Meeting Abstract C1 ARMED FORCES INST PATHOL, DEPT DERMATOPATHOL, WASHINGTON, DC 20306 USA. ARMED FORCES INST PATHOL, DEPT HEMATOPATHOL, WASHINGTON, DC 20306 USA. WALTER REED ARMY INST RES, WASHINGTON, DC USA. NATL NAVAL MED CTR, DEPT DERMATOL, BETHESDA, MD USA. HENRY H JACKSON FDN, BETHESDA, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU BLACKWELL SCIENCE INC PI CAMBRIDGE PA 238 MAIN ST, CAMBRIDGE, MA 02142 SN 0022-202X J9 J INVEST DERMATOL JI J. Invest. Dermatol. PD APR PY 1994 VL 102 IS 4 BP 569 EP 569 PG 1 WC Dermatology SC Dermatology GA NF406 UT WOS:A1994NF40600299 ER PT J AU SARDAR, DK VIZCARRA, S ISLAM, MA ALLIK, TH SHARP, EJ PINTO, AA AF SARDAR, DK VIZCARRA, S ISLAM, MA ALLIK, TH SHARP, EJ PINTO, AA TI CHARACTERIZATION OF SPECTROSCOPIC PROPERTIES OF ND3+-CAZN2Y2GE3O12 (CAZGAR) SO JOURNAL OF LUMINESCENCE LA English DT Article; Proceedings Paper CT 1993 International Conference on Luminescence (ICL 93) CY AUG 09-13, 1993 CL UNIV CONNECTICUT, STORRS, CT SP UNIV CONNECTICUT, OPT SOC AMER, AMER PHYS SOC, IEEE, LASER & ELECTRO OPT SOC, INT UNION PURE & APPL PHYS, INT SCI FDN, UNIV CONNECTICUT RES FDN HO UNIV CONNECTICUT AB A spectroscopic investigation and Judd-Ofelt analysis of Nd3+ doped CaZn2y2Ge3O12 (CAZGAR) has been performed. The broader absorption near 805 nm, longer fluorescence lifetime of 285 mus and the larger branching ratio of 40% for the F-4(3/2) to I-4(9/2) manifold are improvements over Nd3+:YAG as a 941 nm laser material. The effects of color centers induced by ultraviolet irradiation of CAZGAR are also discussed. C1 SCI APPLICAT INT CORP,MCLEAN,VA 22102. ARMY RES LAB,FT BELVOIR,VA 22060. RP SARDAR, DK (reprint author), UNIV TEXAS,DIV EARTH & PHYS SCI,SAN ANTONIO,TX 78249, USA. NR 5 TC 11 Z9 11 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-2313 J9 J LUMIN JI J. Lumines. PD APR PY 1994 VL 60-1 BP 97 EP 100 DI 10.1016/0022-2313(94)90103-1 PG 4 WC Optics SC Optics GA NR361 UT WOS:A1994NR36100026 ER PT J AU SHEN, H AF SHEN, H TI MODULATION SPECTROSCOPY CHARACTERIZATION OF SEMICONDUCTOR MICROSTRUCTURES AND SEMICONDUCTOR-DEVICES SO JOURNAL OF LUMINESCENCE LA English DT Article; Proceedings Paper CT 1993 International Conference on Luminescence (ICL 93) CY AUG 09-13, 1993 CL UNIV CONNECTICUT, STORRS, CT SP UNIV CONNECTICUT, OPT SOC AMER, AMER PHYS SOC, IEEE, LASER & ELECTRO OPT SOC, INT UNION PURE & APPL PHYS, INT SCI FDN, UNIV CONNECTICUT RES FDN HO UNIV CONNECTICUT ID PHOTOREFLECTANCE CHARACTERIZATION; DOPED HETEROJUNCTIONS; FERMI LEVEL; GAAS; ELECTROMODULATION; ELECTROREFLECTANCE; HETEROSTRUCTURES; SPECTRA; FIELD AB Applications of modulation spectroscopy for characterization of semiconductor microstructures and devices are reviewed. Particular emphasis is given to non-destructive, contactless techniques such as photoreflectance. C1 GEO CTRS INC,LAKE HOPATCONG,NJ 07849. RP SHEN, H (reprint author), USA,RES LAB,ELECTR & POWER SOURCE DIRECTORATE,AMSRL,EP,EF,FT MONMOUTH,NJ 07703, USA. NR 22 TC 5 Z9 5 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-2313 J9 J LUMIN JI J. Lumines. PD APR PY 1994 VL 60-1 BP 287 EP 292 DI 10.1016/0022-2313(94)90148-1 PG 6 WC Optics SC Optics GA NR361 UT WOS:A1994NR36100071 ER PT J AU HU, B KARASZ, FE MORTON, DC SOKOLIK, I YANG, Z AF HU, B KARASZ, FE MORTON, DC SOKOLIK, I YANG, Z TI PHOTOLUMINESCENCE AND ELECTROLUMINESCENCE OF NEW PPV-BASED LIGHT-EMITTING COPOLYMERS SO JOURNAL OF LUMINESCENCE LA English DT Article; Proceedings Paper CT 1993 International Conference on Luminescence (ICL 93) CY AUG 09-13, 1993 CL UNIV CONNECTICUT, STORRS, CT SP UNIV CONNECTICUT, OPT SOC AMER, AMER PHYS SOC, IEEE, LASER & ELECTRO OPT SOC, INT UNION PURE & APPL PHYS, INT SCI FDN, UNIV CONNECTICUT RES FDN HO UNIV CONNECTICUT AB Photoluminescence and electroluminescence in new PPV-based copolymers and in their low molar mass model analogs were studied. The separation of the chromophoric units in the copolymer chain by inert aliphatic spacers ca. 4-12 angstrom in length did not significantly effect the luminescence behavior. Light emission is due to the radiative deactivation of singlet excitations located at the chromophoric units generated either by light or formed as a result of the recombination of charge carriers injected from the adjacent electrodes. C1 UNIV MASSACHUSETTS,DEPT POLYMER SCI & ENGN,AMHERST,MA 01003. USA,LAB COMMAND,EPSD,FT MONMOUTH,NJ 07703. RI Hu, Bin/A-2954-2015 OI Hu, Bin/0000-0002-1573-7625 NR 5 TC 27 Z9 27 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-2313 J9 J LUMIN JI J. Lumines. PD APR PY 1994 VL 60-1 BP 919 EP 922 DI 10.1016/0022-2313(94)90312-3 PG 4 WC Optics SC Optics GA NR361 UT WOS:A1994NR36100236 ER PT J AU CIRILLO, R AF CIRILLO, R TI POLES APART - THE POLISH-AIRBORNE AT THE BATTLE-OF-ARNHEM - CHOLEWCZYNSKI,GF SO JOURNAL OF MILITARY HISTORY LA English DT Book Review RP CIRILLO, R (reprint author), USA,CTR MIL HIST,WASHINGTON,DC, USA. NR 1 TC 0 Z9 0 U1 0 U2 2 PU VIRGINIA MILITARY INST PI LEXINGTON PA LEXINGTON, VA 24450 SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD APR PY 1994 VL 58 IS 2 BP 343 EP 344 DI 10.2307/2944047 PG 2 WC History SC History GA NE443 UT WOS:A1994NE44300030 ER PT J AU RAINES, EF AF RAINES, EF TI HISTORY OF THE JOINT-CHIEFS-OF-STAFF, VOL 6, THE JOINT-CHIEFS-OF-STAFF AND NATIONAL POLICY, 1955-1956 - CONDIT,KW SO JOURNAL OF MILITARY HISTORY LA English DT Book Review RP RAINES, EF (reprint author), USA,CTR MIL HIST,WASHINGTON,DC, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU VIRGINIA MILITARY INST PI LEXINGTON PA LEXINGTON, VA 24450 SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD APR PY 1994 VL 58 IS 2 BP 348 EP 348 DI 10.2307/2944051 PG 1 WC History SC History GA NE443 UT WOS:A1994NE44300034 ER PT J AU VIOLA, JM DITZLER, TF KELLAR, MA HANING, WF AF VIOLA, JM DITZLER, TF KELLAR, MA HANING, WF TI POSTTRAUMATIC-STRESS-DISORDER AND SOCIOPOLITICAL CONTEXT - A COMMENT SO JOURNAL OF NERVOUS AND MENTAL DISEASE LA English DT Letter C1 UNIV HAWAII MANOA,JOHN A BURNS SCH MED,HONOLULU,HI. RP VIOLA, JM (reprint author), TRIPLER ARMY MED CTR,HONOLULU,HI 96859, USA. NR 2 TC 1 Z9 1 U1 0 U2 1 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-3018 J9 J NERV MENT DIS JI J. Nerv. Ment. Dis. PD APR PY 1994 VL 182 IS 4 BP 245 EP 245 DI 10.1097/00005053-199404000-00013 PG 1 WC Clinical Neurology; Psychiatry SC Neurosciences & Neurology; Psychiatry GA NE364 UT WOS:A1994NE36400013 PM 10678327 ER PT J AU LONG, JB RIGAMONTI, DD OLESHANSKY, MA WINGFIELD, CP MARTINEZARIZALA, A AF LONG, JB RIGAMONTI, DD OLESHANSKY, MA WINGFIELD, CP MARTINEZARIZALA, A TI DYNORPHIN A-INDUCED RAT SPINAL-CORD INJURY - EVIDENCE FOR EXCITATORY AMINO-ACID INVOLVEMENT IN A PHARMACOLOGICAL MODEL OF ISCHEMIC SPINAL-CORD INJURY SO JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS LA English DT Article ID FOCAL CEREBRAL-ISCHEMIA; BLOOD-FLOW; SUBARACHNOID INJECTION; HINDLIMB PARALYSIS; ANESTHETIZED RAT; NMDA ANTAGONIST; BRAIN MEMBRANES; BINDING-SITES; RECEPTOR; DEXTROMETHORPHAN AB Dynorphin A reduced lumbosacral blood flow, elevated cerebrospinal fluid lactic acid concentrations and caused flaccid hindlimb paralysis and striking neuropathological changes after its injection into the spinal subarachnoid space in rats. Coadministration of the vasodilator hydralazine substantially eliminated the paralytic, anaerobic metabolic and neuropathological responses to dynorphin A. In contrast, in concentrations up to 1 mM, dynorphin A did not alter the viability of cultured rat spinal cord neurons. Thus, it appears that this peptide lacks direct neurotoxic effects and that neuronal injuries in vivo result primarily from ischemia associated with dynorphin A-induced blood flow reductions. NMDA receptor antagonists significantly improved recovery from dynorphin A-induced hindlimb paralysis, and substantially eliminated neuropathological changes without attenuating the acute blood flow reductions or lactic acid elevations. Additionally, glutamate and aspartate concentrations were increased significantly in spinal cord cerebrospinal fluid samples removed during the time that peptide-induced spinal cord blood flow reductions were observed. In contrast, neither amino acid concentration was elevated in media removed after 1-hr exposure of spinal cord neuronal cell cultures to 100 mu M concentrations of dynorphin A. These results indicate that the paralysis and spinal cord injuries produced in rats after spinal subarachnoid injection of dynorphin A result predominantly from spinal cord ischemia, and further identify excitatory amino acids and N-methyl-D-aspartate receptor mechanisms as important mediators in this injury model. C1 UNIV MIAMI,SCH MED,MIAMI PROJECT,MIAMI,FL. RP LONG, JB (reprint author), WALTER REED ARMY INST RES,DEPT MED NEUROSCI,DIV NEUROPSYCHIAT,NEUROPHARMACOL BRANCH,WASHINGTON,DC 20307, USA. NR 44 TC 55 Z9 61 U1 0 U2 1 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-3565 J9 J PHARMACOL EXP THER JI J. Pharmacol. Exp. Ther. PD APR PY 1994 VL 269 IS 1 BP 358 EP 366 PG 9 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA NJ323 UT WOS:A1994NJ32300050 PM 7909561 ER PT J AU FOLEY, DA AF FOLEY, DA TI HUMAN-RESOURCE MANAGEMENT FOR 21ST-CENTURY - MANAGING DIVERSITY SO JOURNAL OF PROFESSIONAL ISSUES IN ENGINEERING EDUCATION AND PRACTICE LA English DT Article AB As the end of the twentieth century rapidly approaches, the time has come for the civil engineering profession to assess its human-resource practices in preparation for the coming century. The key to effective and efficient management in the twenty-first century will be diversity management. This requires an understanding of the demographic and social changes that have so greatly impacted the workplace during the last part of the twentieth century, and of the changes needed in current human-resource management practices to accommodate diversity in the workforce. This article begins with an overview of the demographic and social changes that have occurred in the workplace during the past 40 years. The impact of these changes on both the general workforce and the civil engineering profession is discussed. Finally, it concludes by identifying and discussing several of the human-resource issues that must be addressed for effective management of diversity in the workforce of today and tomorrow. RP FOLEY, DA (reprint author), USA,CORPS ENGRS,ST PAUL DIST,190 5TH ST,ST PAUL,MN 55101, USA. NR 19 TC 1 Z9 1 U1 1 U2 1 PU ASCE-AMER SOC CIVIL ENGINEERS PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 1052-3928 J9 J PROF ISS ENG ED PR JI J. Prof. Issues Eng. Educ. Pract. PD APR PY 1994 VL 120 IS 2 BP 121 EP 128 DI 10.1061/(ASCE)1052-3928(1994)120:2(121) PG 8 WC Education, Scientific Disciplines; Engineering, Multidisciplinary SC Education & Educational Research; Engineering GA NE064 UT WOS:A1994NE06400001 ER PT J AU SAMLASKA, CP WINFIELD, EA AF SAMLASKA, CP WINFIELD, EA TI PENTOXIFYLLINE SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Review ID TUMOR-NECROSIS-FACTOR; HUMAN-IMMUNODEFICIENCY-VIRUS; MARROW TRANSPLANT RECIPIENTS; KASABACH-MERRITT SYNDROME; PLASMA-FIBRINOGEN LEVELS; BLOOD MONONUCLEAR-CELLS; ACUTE RENAL DYSFUNCTION; FACTOR-ALPHA; PLATELET-AGGREGATION; AMPHOTERICIN-B AB Pentoxifylline (oxpentifylline) is a methylxanthine derivative with potent hemorrheologic properties. In the United States it is marketed for the treatment of intermittent claudication. Human and animal studies have shown that pentoxifylline therapy results in a variety of physiologic changes at the cellular level, which may be important in treating a diverse group of human afflictions. Immune modulation includes increased leukocyte deformability and chemotaxis, decreased endothelial leukocyte adhesion, decreased neutrophil degranulation and release of superoxides, decreased production of monocyte-derived tumor necrosis factor, decreased leukocyte responsiveness to interleukin 1 and tumor necrosis factor, inhibition of T and B lymphocyte activation, and decreased natural killer cell activity. Hypercoagulable states improve through decreased platelet aggregation and adhesion, increased plasminogen activator, increased plasmin, increased antithrombin III, decreased fibrinogen, decreased alpha(2)-antiplasmin, decreased alpha(1)-antitrypsin, and decreased az-macroglobulin. Wound healing and connective tissue disorders may respond to an increase in fibroblast collagenases and decreased collagen, fibronectin, and glycosaminoglycan production. Fibroblast responsiveness to tumor necrosis factor is also diminished. Potential medical uses of pentoxifylline are reviewed. C1 TRIPLER ARMY MED CTR,TRANSIT MED SERV,HONOLULU,HI 96859. RP SAMLASKA, CP (reprint author), TRIPLER ARMY MED CTR,SERV DERMATOL,HONOLULU,HI 96859, USA. NR 202 TC 179 Z9 185 U1 0 U2 5 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD APR PY 1994 VL 30 IS 4 BP 603 EP 621 PG 19 WC Dermatology SC Dermatology GA NE852 UT WOS:A1994NE85200012 PM 8157787 ER PT J AU NGO, D PINNICK, RG AF NGO, D PINNICK, RG TI SUPPRESSION OF SCATTERING RESONANCES IN INHOMOGENEOUS MICRODROPLETS SO JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION LA English DT Article ID MORPHOLOGY-DEPENDENT RESONANCES; STIMULATED RAMAN-SCATTERING; DROPLETS; EMISSION; SPHERES; PARTICLES AB Resonance structure in elastic scattering was measured for evaporating micrometer-sized glycerol droplets suspended in an electrodynamic trap. Seeding the droplets with polystyrene latex particles having a diameter of 30 nm less-than-or-equal-to d less-than-or-equal-to 105 nm broadens and attenuates the highest Q (with bare Q almost-equal-to 10(3) - 10(5)) resonances, where Q is defined as the ratio of the energy stored to the energy lost from a cavity per cycle. Regardless of whether resonance conditions are satisfied, the presence of latex particles causes fluctuations in the scattering with an amplitude of up to almost-equal-to 30% of the total signal. Model calculations suggest that the fluctuations may be due at least partially to agglomerated latex particles passing through hot-spot regions within the droplet. C1 USA,RES LAB,WHITE SANDS MISSILE RANGE,NM 88002. RP NGO, D (reprint author), NEW MEXICO STATE UNIV,DEPT PHYS,LAS CRUCES,NM 88003, USA. NR 17 TC 39 Z9 39 U1 0 U2 4 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0740-3232 J9 J OPT SOC AM A JI J. Opt. Soc. Am. A-Opt. Image Sci. Vis. PD APR PY 1994 VL 11 IS 4 BP 1352 EP 1359 DI 10.1364/JOSAA.11.001352 PG 8 WC Optics SC Optics GA NE243 UT WOS:A1994NE24300018 ER PT J AU FRANCESCONI, RP LEVA, NM JOHNSON, CR HUBBARD, RW AF FRANCESCONI, RP LEVA, NM JOHNSON, CR HUBBARD, RW TI POTASSIUM-DEFICIENCY IN RATS - EFFECTS ON RATES OF DEHYDRATION AND ELECTROLYTE HOMEOSTASIS SO JOURNAL OF THERMAL BIOLOGY LA English DT Article DE HYPOHYDRATION; TISSUE ELECTROLYTES; POTASSIUM DEFICIENCY ID ACTIVE-TRANSPORT; DEPLETED RATS; MUSCLES; SODIUM; MODEL; HEATSTROKE; OUABAIN; BINDING; CELLS; K+ AB 1. Three groups of rats were fed a nutritionally complete (C), potassium-deficient (-K), or potassium-supplemented (+K) diet for 28 days followed by passive exposure to a moderate heat stress (T-amb = 31.5 degrees C) until a hypohydration level of 8-9% of initial body weight was achieved. 2. Significant (P < 0.05) hypokalemia was achieved in the -K group and, while final T-re was also increased (P < 0.05 vs C) in this group, time to achieve hypohydration and water loss during heat stress were unaffected. 3. Potassium (K+) levels were decreased and sodium (Na+) concentrations were increased in selected striated muscles of both the +K and -K groups (vs C), but electrolytes in critical tissues (heart, brain, kidney, liver) were unaffected by dietary intake. 4. The moderate hyperthermia achieved during the dehydration interval elicited minor effects on several indices of heat stress/injury. RP FRANCESCONI, RP (reprint author), USA,ENVIRONM MED RES INST,NATICK,MA 01760, USA. NR 29 TC 1 Z9 1 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0306-4565 J9 J THERM BIOL JI J. Therm. Biol. PD APR PY 1994 VL 19 IS 2 BP 129 EP 134 DI 10.1016/0306-4565(94)90060-4 PG 6 WC Biology; Zoology SC Life Sciences & Biomedicine - Other Topics; Zoology GA NU122 UT WOS:A1994NU12200007 ER PT J AU CIOFFI, WG MCMANUS, AT RUE, LW MASON, AD MCMANUS, WF PRUITT, BA AF CIOFFI, WG MCMANUS, AT RUE, LW MASON, AD MCMANUS, WF PRUITT, BA TI COMPARISON OF ACID NEUTRALIZING AND NONACID NEUTRALIZING STRESS-ULCER PROPHYLAXIS IN THERMALLY INJURED PATIENTS SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article; Proceedings Paper CT 53rd Annual Session of the American-Association-for-the-Surgery-of-Trauma CY SEP 23-25, 1993 CL NEW ORLEANS, LA SP AMER ASSOC SURG TRAUMA ID INTENSIVE-CARE UNIT; ACUTE GASTRODUODENAL DISEASE; NOSOCOMIAL PNEUMONIA; GASTRIC COLONIZATION; VENTILATED PATIENTS; ABDOMINAL-TRAUMA; SEPTIC MORBIDITY; CRITICALLY ILL; SUCRALFATE; METAANALYSIS AB We have compared the effectiveness of non-acid neutralizing stress ulcer prophylaxis (SUC) with sucralfate (n = 48) with that of acid neutralizing prophylaxis (AN) utilizing antacids and cimetidine (n = 48) in the prevention of stress ulcer bleeding and nosocomial pneumonia (PN) in thermally injured patients. In the subset of intubated patients, the incidence of PN was 17.8% and 42.8% in the AN and SUC groups, respectively(p < 0.05) despite a similar postburn time of onset of pneumonia. Ten patients in each group died. Three patients in the SUC group developed upper GI bleeding with one requiring gastrectomy. Bacterial colonization of the upper airway occurred in virtually all patients, whereas 83% (SUC) and 96% (AN) had colonization of gastric contents. Gram-negative colonization rates for the upper airway were not different (70%) whereas 48% of SUC patients compared with 60% of AN patients had gram-negative gastric colonization. In conclusion, SUC therapy was efficacious in the prevention of stress ulcer bleeding but did not alter the rate of bacterial colonization of the airway or gastric contents, and was associated with a higher incidence of nosocomial pneumonia in intubated patients. RP CIOFFI, WG (reprint author), USA,INST SURG RES,LIB BRANCH,FT SAM HOUSTON,TX 78234, USA. NR 34 TC 11 Z9 11 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 1079-6061 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD APR PY 1994 VL 36 IS 4 BP 541 EP 547 DI 10.1097/00005373-199404000-00014 PG 7 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA NG222 UT WOS:A1994NG22200014 ER PT J AU FOX, JT CORDTS, PR GWINN, BC AF FOX, JT CORDTS, PR GWINN, BC TI TRAUMATIC ANEURYSM OF THE SUPERFICIAL TEMPORAL ARTERY - CASE-REPORT SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Note AB Traumatic aneurysms of the temporal artery are uncommon, with less than 200 cases reported in the literature. A case resulting from a head injury from playing a popular new survival game known as ''paintball'' is presented here. A general review of the literature on traumatic temporal artery aneurysms is provided, as well as information on this new form of recreation and safety recommendations for ''paintball'' players. C1 TRIPLER ARMY MED CTR,VASC SURG SECT,HONOLULU,HI. RP FOX, JT (reprint author), TRIPLER ARMY MED CTR,DEPT GEN SURG,HONOLULU,HI 96859, USA. NR 29 TC 39 Z9 39 U1 1 U2 1 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 1079-6061 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD APR PY 1994 VL 36 IS 4 BP 562 EP 564 DI 10.1097/00005373-199404000-00017 PG 3 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA NG222 UT WOS:A1994NG22200017 PM 8158720 ER PT J AU BARTH, J AF BARTH, J TI THE SMART MONEY GUIDE TO BARGAIN HOMES - HOW TO FIND AND BUY FORECLOSURES - WIEDEMER,JI SO LIBRARY JOURNAL LA English DT Book Review RP BARTH, J (reprint author), US MIL ACAD,W POINT,NY 10996, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 SN 0363-0277 J9 LIBR J JI Libr. J. PD APR 1 PY 1994 VL 119 IS 6 BP 115 EP 115 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA ND625 UT WOS:A1994ND62500130 ER PT J AU KOSHES, RJ ROTHBERG, JM AF KOSHES, RJ ROTHBERG, JM TI COMPLIANCE WITH CONSULTATIONS IN A MILITARY PSYCHIATRY CLINIC SO MILITARY MEDICINE LA English DT Article AB The study was undertaken to determine the effect of increased information in the referral process on compliance in routine consultations to a military outpatient psychiatry clinic. To evaluate the potential beneficial effects of facilitating factors in a clinic with over 70% baseline compliance, the psychiatrist's name and information about the clinic was provided to one-half of all patients who presented with a routine consult during a 2-month period. There was no increase in compliance rates for patients who were given more than standard information. These results have impact on manpower and staffing issues for the military. RP KOSHES, RJ (reprint author), WALTER REED ARMY MED CTR,DEPT PSYCHIAT,WASHINGTON,DC 20307, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD APR PY 1994 VL 159 IS 4 BP 310 EP 313 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA NX696 UT WOS:A1994NX69600016 PM 20058427 ER PT J AU JONAS, WB AF JONAS, WB TI HEALTH GOALS OF UNITED-STATES-ARMY SOLDIERS - WHAT THEY WANT SO MILITARY MEDICINE LA English DT Article AB This study examined the personal health goals and needs of 1,299 soldiers during their periodic health exam at Fort Belvoir, Virginia, from January 1 to December 31, 1990. The two most important goals of this population were improving self-esteem (50%) and family relationships (43%). In contrast, smoking cessation (17%) and avoiding problems with alcohol (4.3%) were listed 14th and 19th priority, and were desired by only 56% and 61%, respectively, of those who needed help in these areas. Differences between soldiers' health goals and health needs must be considered when designing successful health-promotion programs. RP JONAS, WB (reprint author), WALTER REED ARMY MED CTR,DIV MED,WASHINGTON,DC 20307, USA. NR 0 TC 1 Z9 1 U1 1 U2 2 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD APR PY 1994 VL 159 IS 4 BP 318 EP 322 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA NX696 UT WOS:A1994NX69600018 PM 20058429 ER PT J AU CHISICK, MC AF CHISICK, MC TI CONTINUING-EDUCATION NEEDS OF NON-SPECIALTY-TRAINED ARMY GENERAL DENTISTS SO MILITARY MEDICINE LA English DT Article AB In this survey, preferences for dental continuing education (C.E.) topics for non-specialty-trained Army general dentists were explored across personal and practice characteristics and were compared with C.E. topics that their supervisors think they need. Among general dentists, preferences for dental C.E. topics were found to vary across level of training, assignment location, experience, and presence of specialists in clinic of assignment. C.E. preferences of general dentists were found to be more narrowly clinically focused than those that their supervisors think they need. All groups ranked Management of Medical Emergencies as the most needed dental C.E. topic. The current inventory of Army dental C.E. courses is meeting the needs expressed by survey respondents with the exception of human relations courses. Topics such as Motivating Co-Workers, Management of Job Stress, and Working with Difficult People, which received high ratings in this survey, should be incorporated into the Army dental C.E. system. RP CHISICK, MC (reprint author), USA,INST DENT RES,EPIDEMIOL SECT,FT GEORGE G MEADE,MD 20755, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD APR PY 1994 VL 159 IS 4 BP 327 EP 331 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA NX696 UT WOS:A1994NX69600020 PM 20058431 ER PT J AU KANTROWITZ, FT WATKINS, WR AF KANTROWITZ, FT WATKINS, WR TI BANDPASS OPTIMIZATION FOR LOW-ALTITUDE LONG-PATH INFRARED IMAGING SO OPTICAL ENGINEERING LA English DT Article DE INFRARED IMAGING; ATMOSPHERIC PROPAGATION; PATH RADIANCE; CONTRAST TRANSMISSION AB Over relatively long paths near the earth's surface, atmospheric radiance can be a significant contributor to a poor SNR. These radiant emissions are primarily from atmospheric constituents such as H2O and CO2. Many commercially available IR imagers utilizing mercury-cadmium-telluride scanning detectors are not optimized for long horizontal path research. The degradation in the detected SNR due to atmospheric effects makes it advisable to use detectors that are sensitive in wavelength regions where the atmospheric attenuation is minimal. Through proper doping of the detector and cold finger filtering, there is an increase in the magnitude of the detected target radiance and a much more favorable ratio of target-to-path radiance that directly affects the image quality. We present a methodology that has resulted in a computer algorithm that is used to predict optimal system response conditions. Preliminary results show a 5% to 10% enhancement of the target-to-background apparent temperature or DELTAT in the 8- to 12-mum region over a relatively short path. RP KANTROWITZ, FT (reprint author), USA,RES LAB,WHITE SANDS MISSILE RANGE,NM 88002, USA. NR 13 TC 3 Z9 5 U1 0 U2 0 PU SOC PHOTO-OPT INSTRUM ENG PI BELLINGHAM PA PO BOX 10, BELLINGHAM, WA 98227-0010 SN 0091-3286 J9 OPT ENG JI Opt. Eng. PD APR PY 1994 VL 33 IS 4 BP 1114 EP 1119 DI 10.1117/12.163203 PG 6 WC Optics SC Optics GA NG450 UT WOS:A1994NG45000017 ER PT J AU HUANG, Q GILBERT, JA CAULFIELD, HJ AF HUANG, Q GILBERT, JA CAULFIELD, HJ TI HOLOGRAPHIC-INTERFEROMETRY USING SUBSTRATE GUIDED-WAVES SO OPTICAL ENGINEERING LA English DT Article DE HOLOGRAPHIC INTERFEROMETRY; NONDESTRUCTIVE EVALUATION; METROLOGY; WAVE-GUIDE HOLOGRAPHY AB A new tool for experimental mechanics called substrate guided wave (SGW) holo-interferometry is described. The approach relies on recording and reconstructing time-average, double-exposure, and real-time holograms using light waves guided to the hologram by a dielectric sheet or substrate waveguide. The study illustrates that SGW holo-interferometry can be used to isolate the reference wavefront from the environment surrounding the hologram and can be applied to measure the mechanical properties of the substrate itself. These attributes are discussed along with experimental work performed to develop and refine the technique. C1 UNIV ALABAMA,DEPT MECH & AEROSP ENGN,HUNTSVILLE,AL 35899. ALABAMA A&M UNIV,DEPT PHYS,NORMAL,AL 35762. RP HUANG, Q (reprint author), USA,MISSILE COMMAND,WEAPONS SCI DIRECTORATE,REDSTONE ARSENAL,AL 35898, USA. NR 15 TC 4 Z9 4 U1 0 U2 0 PU SOC PHOTO-OPT INSTRUM ENG PI BELLINGHAM PA PO BOX 10, BELLINGHAM, WA 98227-0010 SN 0091-3286 J9 OPT ENG JI Opt. Eng. PD APR PY 1994 VL 33 IS 4 BP 1132 EP 1137 DI 10.1117/12.163188 PG 6 WC Optics SC Optics GA NG450 UT WOS:A1994NG45000020 ER PT J AU KARPAS, Z EICEMAN, GA HARDEN, CS EWING, RG SMITH, PBW AF KARPAS, Z EICEMAN, GA HARDEN, CS EWING, RG SMITH, PBW TI COLLISION-INDUCED DISSOCIATION STUDIES OF PROTONATED ALCOHOL AND ALCOHOL-WATER CLUSTERS BY ATMOSPHERIC-PRESSURE IONIZATION TANDEM MASS-SPECTROMETRY .1. METHANOL SO ORGANIC MASS SPECTROMETRY LA English DT Article ID ION MOLECULE REACTIONS; MULTIPHOTON IONIZATION; DIMETHYL ETHER; MIXED CLUSTERS; MAGIC NUMBERS; HYDROGEN-ION; SOLVATION; GAS; THERMOCHEMISTRY; FRAGMENTATION AB Cluster size distribution and collision-induced dissociation (CID) studies of protonated methanol and protonated methanol-water clusters yield information on the structure and energetics of such ions. Ions were formed at atmospheric pressure in a corona discharge source, and were subjected to CID in the center quadrupole of a triple quadrupole mass spectrometer. Cluster ions containing up to 13 molecules of methanol and/or water were observed and examined using CID experiments. The CID of all (CH3OH)n . H2O . H+ clusters, where n less-than-or-equal-to 8, showed that water loss was statistically favored over methanol loss and that the preferred dissociation channel involved loss of water with methanol molecules. These results support a model employing a chain of hydrogen-bonded solvent molecules rather than one in which fused rings of ligands surround a central hydronium ion. However, CID of larger clusters, where n greater-than-or-equal-to 9, showed that loss of one methanol was equal to or less than loss of water, reflecting a change in structure. C1 USA,EDGEWOOD RES DEV & ENGN CTR,ABERDEEN PROVING GROUND,MD 21010. GEOCENTERS INC,GUNPOWDER BRANCH,ABERDEEN PROVING GROUND,MD 21010. NUCL RES CTR NEGEV,DEPT CHEM,IL-84190 BEER SHEVA,ISRAEL. RP KARPAS, Z (reprint author), NEW MEXICO STATE UNIV,DEPT CHEM,LAS CRUCES,NM 88003, USA. NR 37 TC 10 Z9 10 U1 1 U2 3 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0030-493X J9 ORG MASS SPECTROM JI Org. Mass Spectrom. PD APR PY 1994 VL 29 IS 4 BP 159 EP 168 DI 10.1002/oms.1210290402 PG 10 WC Chemistry, Organic; Spectroscopy SC Chemistry; Spectroscopy GA NK332 UT WOS:A1994NK33200001 ER PT J AU ROSCELLI, JD YU, CE SOUTHGATE, WM AF ROSCELLI, JD YU, CE SOUTHGATE, WM TI MANAGEMENT OF SALT POISONING IN AN EXTREMELY LOW-BIRTH-WEIGHT INFANT SO PEDIATRIC NEPHROLOGY LA English DT Article DE DIALYSIS; FUROSEMIDE; HYPERNATREMIA; NECROTIZING ENTEROCOLITIS; PREMATURE INFANT; SALT POISONING AB We present the first reported case of severe salt poisoning in an extremely low birth weight neonate. The salt poisoning was managed with the careful use of intravenous fluids, insulin to manage the severe hyperglycemia, and furosemide to induce a saline diuresis. The hypertonicity was normalized slowly over 3 days by following the corrected serum sodium (Na) (serum Na + 2.7 mEq for every 100 mg/dl of glucose over 100). No neurological damage was seen in our patient during the development of the hypertonicity or its correction. This suggests that the premature brain can develop osmo-protective molecules if hypertonicity develops slowly over 2-3 days. Slow correction is therefore recommended to avoid the development of water intoxication during correction. Despite the development of mild reversible renal failure, a large saline diuresis was induced with furosemide, thereby avoiding the need for dialysis in our patient. The only complication was the development of necrotizing enterocolitis, which has not been previously reported in association with salt poisoning. C1 TRIPLER ARMY MED CTR,DEPT PEDIAT,HONOLULU,HI 96859. NR 0 TC 3 Z9 3 U1 0 U2 0 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0931-041X J9 PEDIATR NEPHROL JI Pediatr. Nephrol. PD APR PY 1994 VL 8 IS 2 BP 172 EP 174 PG 3 WC Pediatrics; Urology & Nephrology SC Pediatrics; Urology & Nephrology GA NC629 UT WOS:A1994NC62900009 PM 8018494 ER PT J AU ASCHER, DP WAECKER, NJ OTTOLINI, MA RASZKA, WV MORIARTY, R ROBB, ML AF ASCHER, DP WAECKER, NJ OTTOLINI, MA RASZKA, WV MORIARTY, R ROBB, ML TI SIGNIFICANCE OF THE IMMUNE-COMPLEX DISSOCIATED (ICD) P24 ANTIGEN IN PEDIATRIC HIV-INFECTION SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 WILFORD HALL USAF MED CTR, DEPT PEDIAT, LACKLAND AFB, TX 78236 USA. UNIFORMED SERV UNIV HLTH SCI, BETHESDA, MD 20814 USA. USN HOSP, BETHESDA, MD 20814 USA. NATL NAVAL MED CTR, BETHESDA, MD 20814 USA. WALTER REED ARMY INST RES, WASHINGTON, DC 20307 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1994 VL 35 IS 4 BP A173 EP A173 PN 2 PG 1 WC Pediatrics SC Pediatrics GA NG779 UT WOS:A1994NG77901022 ER PT J AU BIJUR, PE FRIEDMAN, S HORODYSKI, M KURZON, M LIFRAK, S EGERTON, W AF BIJUR, PE FRIEDMAN, S HORODYSKI, M KURZON, M LIFRAK, S EGERTON, W TI COMPARISON OF INJURIES INCURRED DURING BASIC TRAINING BY GENDER SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT PEDIAT,BRONX,NY 10461. US MIL ACAD,MEDACC,W POINT,NY 10996. UNIV FLORIDA,DEPT EXER & SPORTS SCI,GAINESVILLE,FL 32611. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1994 VL 35 IS 4 BP A3 EP A3 PN 2 PG 1 WC Pediatrics SC Pediatrics GA NG779 UT WOS:A1994NG77900004 ER PT J AU DEMERS, DM VINCENT, JM BASS, JW PERSON, DA NOYES, DK STAEGE, CM REGNERY, RL OLSON, JG ANDERSON, BE AF DEMERS, DM VINCENT, JM BASS, JW PERSON, DA NOYES, DK STAEGE, CM REGNERY, RL OLSON, JG ANDERSON, BE TI SEROLOGIC EVIDENCE OF ROCHALIMAEA-HENSELAE (RH) INFECTION AND CAT-SCRATCH DISEASE (CSD) IN HUMANS SCRATCHED BY RH BACTEREMIC KITTENS SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 TRIPLER ARMY MED CTR,HONOLULU,HI 96859. CTR DIS CONTROL,RICKETTSIAL ZOONOSES BRANCH,ATLANTA,GA 30333. RI Anderson, Burt/H-4449-2011 NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1994 VL 35 IS 4 BP A177 EP A177 PN 2 PG 1 WC Pediatrics SC Pediatrics GA NG779 UT WOS:A1994NG77901049 ER PT J AU DRESSEL, MVC IWAMOTO, LM NAKAMURA, KT AF DRESSEL, MVC IWAMOTO, LM NAKAMURA, KT TI PRETERM DELIVERY ALTERS LARGE AIRWAY CONTRACTILITY IN GUINEA-PIGS SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 TRIPLER ARMY MED CTR,KAPIOLANI MED CTR,HONOLULU,HI 96859. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1994 VL 35 IS 4 BP A331 EP A331 PN 2 PG 1 WC Pediatrics SC Pediatrics GA NG779 UT WOS:A1994NG77901967 ER PT J AU GIUSEPPETTI, MM WISWELL, TE AF GIUSEPPETTI, MM WISWELL, TE TI THE USE OF SALINE LAVAGE AND SURFACTANT THERAPY IN THE MANAGEMENT OF A PIGLET MODEL OF THE MECONIUM ASPIRATION SYNDROME (MAS) SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,DEPT PEDIAT,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,DEPT PEDIAT,BETHESDA,MD 20814. NR 0 TC 4 Z9 4 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1994 VL 35 IS 4 BP A333 EP A333 PN 2 PG 1 WC Pediatrics SC Pediatrics GA NG779 UT WOS:A1994NG77901979 ER PT J AU HEIMAN, HS HARRIS, MS RUTENBERG, GW YODER, BA KOOPS, BL AF HEIMAN, HS HARRIS, MS RUTENBERG, GW YODER, BA KOOPS, BL TI A COMPARISON OF PERINATAL OUTCOMES OF MILITARY, PRIVATE, AND PUBLIC-HEALTH CARE DELIVERY SYSTEMS SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 BROOKE ARMY MED CTR,DEPT PEDIAT,SAN ANTONIO,TX. TEXAS DEPT HLTH,AUSTIN,TX. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1994 VL 35 IS 4 BP A272 EP A272 PN 2 PG 1 WC Pediatrics SC Pediatrics GA NG779 UT WOS:A1994NG77901616 ER PT J AU IWAMOTO, LM WILSON, VL AYAU, EL NAKAMURA, KT AF IWAMOTO, LM WILSON, VL AYAU, EL NAKAMURA, KT TI ROLE OF NITRIC-OXIDE IN ENDOTOXIN-EXPOSED GUINEA-PIG AIRWAYS SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 KAPIOLANI MED CTR,DEPT PEDS,HONOLULU,HI. TRIPLER ARMY MED CTR,DEPT CLIN INVEST,HONOLULU,HI 96859. UNIV HAWAII,HONOLULU,HI 96822. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1994 VL 35 IS 4 BP A393 EP A393 PN 2 PG 1 WC Pediatrics SC Pediatrics GA NG779 UT WOS:A1994NG77902336 ER PT J AU IWAMOTO, LM AYAU, EL WILSON, VL NAKAMURA, KT AF IWAMOTO, LM AYAU, EL WILSON, VL NAKAMURA, KT TI DESENSITIZATION TO FUROSEMIDE IN GUINEA-PIG AIRWAY SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 KAPIOLANI MED CTR,DEPT CLIN INVEST,HONOLULU,HI. UNIV HAWAII,HONOLULU,HI 96822. TRIPLER ARMY MED CTR,HONOLULU,HI 96859. NR 0 TC 0 Z9 0 U1 1 U2 1 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1994 VL 35 IS 4 BP A84 EP A84 PN 2 PG 1 WC Pediatrics SC Pediatrics GA NG779 UT WOS:A1994NG77900489 ER PT J AU SOOD, SL FINN, KC MUNDIE, TG WILKERSON, SY EASA, D AF SOOD, SL FINN, KC MUNDIE, TG WILKERSON, SY EASA, D TI EXOGENOUS SURFACTANT, EXOSURF(R), DECREASES OXYGENATION IN ENDOTOXIN-TREATED NEONATAL PIGLETS SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 UNIV HAWAII,TRIPLER ARMY MED CTR,KAPIOLANI MED CTR,HONOLULU,HI 96822. NR 0 TC 0 Z9 0 U1 0 U2 1 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1994 VL 35 IS 4 BP A59 EP A59 PN 2 PG 1 WC Pediatrics SC Pediatrics GA NG779 UT WOS:A1994NG77900339 ER PT J AU SOOD, SL EASA, D FINN, KC BALARAMAN, V WILKERSON, SY UYEHARA, CFT AF SOOD, SL EASA, D FINN, KC BALARAMAN, V WILKERSON, SY UYEHARA, CFT TI DIFFERENTIAL-EFFECTS OF CLINICAL SURFACTANTS ON OXYGENATION IN SALINE LUNG-LAVAGED NEONATAL PIGLETS SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 UNIV HAWAII,TRIPLER ARMY MED CTR,KAPIOLANI MED CTR,HONOLULU,HI 96822. NR 0 TC 0 Z9 0 U1 0 U2 1 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1994 VL 35 IS 4 BP A59 EP A59 PN 2 PG 1 WC Pediatrics SC Pediatrics GA NG779 UT WOS:A1994NG77900338 ER PT J AU TIWARY, CM AF TIWARY, CM TI PREMATURE SEXUAL DEVELOPMENT IN CHILDREN FOLLOWING THE USE OF PLACENTA AND OR ESTROGEN CONTAINING HAIR PRODUCT(S) SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 UTHSC,SAN ANTONIO,TX. BROOKE ARMY MED CTR,DEPT PEDIAT,FT SAM HOUSTON,TX 78234. NR 0 TC 1 Z9 1 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1994 VL 35 IS 4 BP A108 EP A108 PN 2 PG 1 WC Pediatrics SC Pediatrics GA NG779 UT WOS:A1994NG77900632 ER PT J AU UYEHARA, CFT MATSUDA, LS AF UYEHARA, CFT MATSUDA, LS TI IMPAIRED RENAL SALT EXCRETION EARLY IN DEVELOPMENT PRECEDES HYPERTENSION IN SPONTANEOUSLY HYPERTENSIVE RATS (SHR) SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 TRIPLER ARMY MED CTR,HONOLULU,HI 96859. KAPIOLANI MED CTR,HONOLULU,HI. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1994 VL 35 IS 4 BP A375 EP A375 PN 2 PG 1 WC Pediatrics SC Pediatrics GA NG779 UT WOS:A1994NG77902228 ER PT J AU VANSCOY, SC CLAYBAUGH, JR UYEHARA, CFT SATO, AK NAKAMURA, KT AF VANSCOY, SC CLAYBAUGH, JR UYEHARA, CFT SATO, AK NAKAMURA, KT TI IMPROVED GAS-EXCHANGE WITH VASOPRESSIN V1-AGONIST IS NOT SEEN WITH OTHER VASOACTIVE AGENTS IN HYPOXIC NEONATAL PIGLETS SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 KAPIOLANI MC,DEPT CLIN INVEST,HONOLULU,HI. TRIPLER ARMY MED CTR,HONOLULU,HI 96859. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1994 VL 35 IS 4 BP A399 EP A399 PN 2 PG 1 WC Pediatrics SC Pediatrics GA NG779 UT WOS:A1994NG77902370 ER PT J AU WISWELL, TE POPEK, E BARFIELD, WD PEABODY, S AF WISWELL, TE POPEK, E BARFIELD, WD PEABODY, S TI THE EFFECT OF INTRAAMNIOTIC MECONIUM ON HISTOLOGIC-FINDINGS OVER TIME IN A FETAL RABBIT MODEL SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. ARMED FORCES INST PATHOL,WASHINGTON,DC 20306. NR 0 TC 3 Z9 3 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1994 VL 35 IS 4 BP A261 EP A261 PN 2 PG 1 WC Pediatrics SC Pediatrics GA NG779 UT WOS:A1994NG77901546 ER PT J AU FERRIS, CF DELVILLE, Y IRVIN, RW POTEGAL, M AF FERRIS, CF DELVILLE, Y IRVIN, RW POTEGAL, M TI SEPTO-HYPOTHALAMIC ORGANIZATION OF A STEREOTYPED BEHAVIOR CONTROLLED BY VASOPRESSIN IN GOLDEN-HAMSTERS SO PHYSIOLOGY & BEHAVIOR LA English DT Article DE FLANK MARKING; ARGININE VASOPRESSIN; LATERAL SEPTUM; ANTERIOR HYPOTHALAMUS; IBOTENIC ACID LESIONS; BILATERAL RECRUITMENT; NEURAL NETWORK ID FLANK-MARKING BEHAVIOR; BINDING-SITES; MAGNOCELLULAR NEURONS; ARGININE-VASOPRESSIN; EFFERENT CONNECTIONS; KAINIC ACID; RAT; MICROINJECTION; PROJECTIONS; BRAIN AB In golden hamsters, microinjections of arginine vasopressin (AW) within the anterior hypothalamus (AH) and lateral septum (LS) elicit the display of a stereotyped behavior: flank marking. As these areas are reciprocally connected, we tested whether AW-sensitive sites constitute an organized network. Flank marking was recorded in animals with ibotenic acid lesions within the AH or LS after AVP injections within the LS or AH. While AVP injections in the AH and LS induced high flank-marking scores, certain lesions blocked the behavior. Lesions of the LS failed to affect flank marking induced by injections within the AH. In contrast, unilateral AH lesions blocked flank marking induced either by LS injections or AH injections in the contralateral side. These results suggest that the bilateral integrity of the AH is critical for the activation of flank-marking behavior by AVP. Together, these data suggest that the AH is an important relay of the neural network controlling flank-marking behavior. C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT MED NEUROSCI,WASHINGTON,DC 20307. RP FERRIS, CF (reprint author), UNIV MASSACHUSETTS,MED CTR,DEPT PSYCHIAT,BEHAV NEUROSCI LAB,55 LAKE AVE N,WORCESTER,MA 01655, USA. FU NINDS NIH HHS [NINDS NS30199] NR 26 TC 38 Z9 42 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0031-9384 J9 PHYSIOL BEHAV JI Physiol. Behav. PD APR PY 1994 VL 55 IS 4 BP 755 EP 759 DI 10.1016/0031-9384(94)90056-6 PG 5 WC Psychology, Biological; Behavioral Sciences SC Psychology; Behavioral Sciences GA NA800 UT WOS:A1994NA80000024 PM 8190806 ER PT J AU SCHUMM, WR BELL, DB PALMERJOHNSON, CE TRAN, G AF SCHUMM, WR BELL, DB PALMERJOHNSON, CE TRAN, G TI GENDER TRENDS IN THE UNITED-STATES-ARMY AND A DISCUSSION OF IMPLICATIONS FOR READINESS AND RETENTION SO PSYCHOLOGICAL REPORTS LA English DT Article ID MILITARY AB The percentage of female soldiers and officers in the U.S. Army has increased dramatically during the last few decades. Gender appears to be correlated with rank, age, education, and race, making it difficult to draw definitive conclusions about the effects of gender on retention or readiness. Evidence regarding gender and retention is mixed, but available evidence on gender and individual and unit readiness suggests that gender does not adversely influence readiness at either level. However, there is little evidence to date on the effects of gender within combat units, leaving that question open to debate. C1 USA,RES INST BEHAV & SOCIAL SCI,PERI RPD,5001 EISENHOWER AVE,ALEXANDRIA,VA 22333. KANSAS STATE UNIV AGR & APPL SCI,MANHATTAN,KS 66506. CATHOLIC UNIV AMER,WASHINGTON,DC 20064. AMERICAN UNIV,WASHINGTON,DC 20016. NR 40 TC 7 Z9 7 U1 0 U2 0 PU PSYCHOLOGICAL REPORTS PI MISSOULA PA P O BOX 9229, MISSOULA, MT 59807 SN 0033-2941 J9 PSYCHOL REP JI Psychol. Rep. PD APR PY 1994 VL 74 IS 2 BP 499 EP 511 PG 13 WC Psychology, Multidisciplinary SC Psychology GA NE106 UT WOS:A1994NE10600031 ER PT J AU PRIDHAM, KF CHANG, A CHIU, YM AF PRIDHAM, KF CHANG, A CHIU, YM TI INFLUENCES ON MOTHERS USE OF CLINICIAN HELP IN THE INFANTS 1ST 3 MONTHS SO PUBLIC HEALTH NURSING LA English DT Article ID INFORMATION-SEEKING; TRANSITION; BEHAVIOR AB Factors that influenced use of physician and nurse help were explored for 49 mothers of healthy, term-born infants for two study periods in the first three months. These factors were concepts pertinent to mothers' internal working models of help use, their resources, perceived problem-solving competence, and clinical evaluation of maternal competence in use of help. Variables contributing to the frequency with which help was used and to the ratio of that help to other communal help sources differed for nurse and physician help and for the time period. For physicians, the number of infant caretaking issues a mother identified contributed to the frequency of help use in both study periods. The problem-solving help nurses gave emerged as a critical help in the second study period. The ratio of help from nurses to that from other sources was higher when mothers identified reassurance from the nurse as a critical help and, in addition, as the infant grew older, when the nurse's evaluation of the mother's use of help was more positive. In contrast, throughout the first three months, the more infant care experience a mother had, the higher the proportion of help from physicians relative to communal sources of help. The findings suggest that nurses and physicians may have complementary functions when a mother uses help. C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. RP PRIDHAM, KF (reprint author), UNIV WISCONSIN,SCH NURSING,600 HIGHLAND AVE,MADISON,WI 53792, USA. NR 41 TC 3 Z9 3 U1 0 U2 1 PU BLACKWELL SCIENCE INC PI CAMBRIDGE PA 238 MAIN ST, CAMBRIDGE, MA 02142 SN 0737-1209 J9 PUBLIC HEALTH NURS JI Public Health Nurs. PD APR PY 1994 VL 11 IS 2 BP 80 EP 89 DI 10.1111/j.1525-1446.1994.tb00178.x PG 10 WC Public, Environmental & Occupational Health; Nursing SC Public, Environmental & Occupational Health; Nursing GA NE305 UT WOS:A1994NE30500004 PM 8029185 ER PT J AU DRABICK, JJ MAGILL, AJ SMITH, KJ NUTMAN, TB BENSON, PM AF DRABICK, JJ MAGILL, AJ SMITH, KJ NUTMAN, TB BENSON, PM TI HYPEREOSINOPHILIC SYNDROME-ASSOCIATED WITH HIV-INFECTION SO SOUTHERN MEDICAL JOURNAL LA English DT Note ID IMMUNODEFICIENCY-VIRUS INFECTION; IMMUNE-DEFICIENCY SYNDROME; BONE-MARROW CULTURES; SELECTIVE LOSS; IGE SYNTHESIS; HOST-DISEASE; SERUM IGE; INTERLEUKIN-5; EOSINOPHILS; MANIFESTATIONS AB A hypereosinophilic syndrome associated with dermatitis has been observed rarely in association with HIV infection. We describe the case of a young man with AIDS who came to us with a diffuse cutaneous eruption, fever, angioedema, eosinophilia, and a mildly elevated serum IgE level. No allergic or infectious cause of this illness could be determined, and the patient was treated with corticosteroids and PUVA therapy, resulting in complete resolution of the dermatitis and associated findings. In this case, there were clinical and histopathologic similarities to the idiopathic hypereosinophilic syndrome and to acute graft-versus-host disease. The serum level of the cytokine interleukin-5 (IL-5), which is associated with eosinophil production, was found to be mildly elevated during the peak of the eruption, while samples drawn previously and subsequently were not. Although it appears that the syndrome we describe is associated with the measurably elevated level of IL-5, further investigation is required to determine whether there is a cause and effect relationship between IL-5 and this entity. A brief review of the literature concerning eosinophils and HIV infection is also presented in the context of this case. C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NIH,BETHESDA,MD 20892. RP DRABICK, JJ (reprint author), WALTER REED ARMY INST RES,DEPT BACTERIAL DIS,WASHINGTON,DC 20307, USA. NR 43 TC 19 Z9 20 U1 0 U2 0 PU SOUTHERN MEDICAL ASSN PI BIRMINGHAM PA 35 LAKESHORE DR PO BOX 190088, BIRMINGHAM, AL 35219 SN 0038-4348 J9 SOUTHERN MED J JI South.Med.J. PD APR PY 1994 VL 87 IS 4 BP 525 EP 529 DI 10.1097/00007611-199404000-00021 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA NG281 UT WOS:A1994NG28100022 PM 8153785 ER PT J AU MIDDLEBROOK, JL LEATHERMAN, DL AF MIDDLEBROOK, JL LEATHERMAN, DL TI EFFECTS OF STEROIDS ON ASSOCIATION OF T-2 TOXIN WITH MAMMALIAN-CELLS SO TOXICON LA English DT Article ID EUKARYOTIC RIBOSOMES; BINDING; TRICHODERMIN; INHIBITION AB The effects of steroids on the association of T-2 toxin with cultured cells were evaluated. Preincubating cells with certain steroids led to a time- and concentration-related increase in total T-2-cell association. At maximally effective concentrations, the increase in association was 300-500%. This effect required a preincubation at 37 degrees C for a minimum of 10 min and was completely reversible after 20-30 min. Steroid treatment increased the rate of toxin-cell association and decreased the rate of dissociation. The effect was elicited by progesterone, estradiol, testosterone and diethylstilbestrol, but not by several other steroids tested. Binding of T-2 to isolated ribosomes was not altered by the steroids. We speculated that steroids somehow alter the state of ribosomal aggregation or assembly such that more toxin can bind after entering the cell. RP MIDDLEBROOK, JL (reprint author), USA,MED RES INST INFECT DIS,DIV TOXICOL,FREDERICK,MD 21702, USA. NR 16 TC 0 Z9 0 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0041-0101 J9 TOXICON JI Toxicon PD APR PY 1994 VL 32 IS 4 BP 435 EP 444 DI 10.1016/0041-0101(94)90295-X PG 10 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA NK681 UT WOS:A1994NK68100005 PM 8052998 ER PT J AU LACEY, PI AF LACEY, PI TI EVALUATION OF OXIDATIVE CORROSION IN DIESEL FUEL LUBRICATED CONTACTS SO TRIBOLOGY TRANSACTIONS LA English DT Article DE HUMIDITY; BOUNDARY LUBRICATION; BENCH TEST; CORROSION INHIBITOR; DIESEL; OXIDATIVE WEAR; CORROSIVE WEAR ID LOW-LUBRICITY FUELS; WEAR AB Previous studies have demonstrated that the durability of some fuel injection systems on compression-ignition engines will be adversely affected by fuels of sufficiently low lubricity. However, no widely accepted lubricity measure is available; indeed, the wear mechanisms present have not been conclusively defined. The results of the present study indicate that oxidative corrosion is the predominant mechanism with very highly processed fuels, resulting in catastrophic wear and rapid failure. Less highly refined fuels contain natural corrosion inhibitors and produce alternate wear mechanisms that may still affect long-term durability. A laboratory test procedure directed toward the oxidative wear mechanism was evaluated and a number of modifications suggested. The resulting test produced good correlation with the full-scale pump and appeared to correlate with the criteria necessary for oxidative corrosion. However, it is recognized that this single test procedure may not fully define the lubricity requirements of the injection system, particularly in the absence of oxidative corrosion or very highly loaded contacts that are susceptible to adhesive wear and scuffing. RP LACEY, PI (reprint author), SW RES INST,USA,BELVOIR FUELS & LUBRICANTS RES FACIL,SAN ANTONIO,TX 78284, USA. NR 19 TC 4 Z9 4 U1 0 U2 2 PU SOC TRIBOLOGISTS & LUBRICATION ENGINEERS PI PARK RIDGE PA 838 BUSSE HIGHWAY, PARK RIDGE, IL 60068 SN 0569-8197 J9 TRIBOL T JI Tribol. Trans. PD APR PY 1994 VL 37 IS 2 BP 253 EP 260 DI 10.1080/10402009408983290 PG 8 WC Engineering, Mechanical SC Engineering GA NE950 UT WOS:A1994NE95000005 ER PT J AU MAYEWSKI, PA MEEKER, LD WHITLOW, S TWICKLER, MS MORRISON, MC BLOOMFIELD, P BOND, GC ALLEY, RB GOW, AJ GROOTES, PM MEESE, DA RAM, M TAYLOR, KC WUMKES, W AF MAYEWSKI, PA MEEKER, LD WHITLOW, S TWICKLER, MS MORRISON, MC BLOOMFIELD, P BOND, GC ALLEY, RB GOW, AJ GROOTES, PM MEESE, DA RAM, M TAYLOR, KC WUMKES, W TI CHANGES IN ATMOSPHERIC CIRCULATION AND OCEAN ICE COVER OVER THE NORTH-ATLANTIC DURING THE LAST 41,000 YEARS SO SCIENCE LA English DT Article ID NITRATE; SNOW AB High-resolution, continuous multivariate, chemical records from a central Greenland ice core provide a sensitive measure of climate change and chemical composition of the atmosphere over the last 41,000 years. These chemical series reveal a record of change in the relative size and intensity of the circulation system that transported air masses to Greenland [defined here as the polar circulation index (PCI)] and in the extent of ocean ice cover. Massive iceberg discharge events previously defined from the marine record are correlated with notable expansions of ocean ice cover and increases in PCI. During stadials without discharge events, ocean ice cover appears to reach some common maximum level. The massive aerosol loadings and dramatic variations in ocean ice cover documented in ice cores should be included in climate modeling. C1 N CAROLINA STATE UNIV,DEPT STAT,RALEIGH,NC 27695. LAMONT DOHERTY EARTH OBSERV,PALISADES,NY 10964. PENN STATE UNIV,CTR EARTH SYST SCI,UNIV PK,PA 16802. PENN STATE UNIV,DEPT GEOSCI,UNIV PK,PA 16802. COLD REG RES & ENGN LAB,HANOVER,NH 03755. UNIV WASHINGTON,QUATERNARY ISOTOPE LAB,SEATTLE,WA 98195. SUNY BUFFALO,DEPT PHYS,AMHERST,NY 14260. UNIV NEVADA,DESERT RES INST,RENO,NV 89506. UNIV ALASKA,POLAR ICE CORING OFF,FAIRBANKS,AK 99775. UNIV NEW HAMPSHIRE,DEPT MATH,DURHAM,NH 03824. RP MAYEWSKI, PA (reprint author), UNIV NEW HAMPSHIRE,INST STUDY EARTH OCEANS & SPACE,GLACIER RES GRP,DURHAM,NH 03824, USA. RI Grootes, Pieter/F-4952-2011; Taylor, Kendrick/A-3469-2016 OI Taylor, Kendrick/0000-0001-8535-1261 NR 22 TC 277 Z9 289 U1 1 U2 27 PU AMER ASSOC ADVANCEMENT SCIENCE PI WASHINGTON PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 SN 0036-8075 J9 SCIENCE JI Science PD MAR 25 PY 1994 VL 263 IS 5154 BP 1747 EP 1751 DI 10.1126/science.263.5154.1747 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA NC040 UT WOS:A1994NC04000031 PM 17795382 ER PT J AU WRABACK, M SHEN, H PAMULAPATI, J DUTTA, M NEWMAN, PG TAYSINGLARA, M LU, Y AF WRABACK, M SHEN, H PAMULAPATI, J DUTTA, M NEWMAN, PG TAYSINGLARA, M LU, Y TI FEMTOSECOND STUDIES OF EXCITONIC OPTICAL NONLINEARITIES IN GAAS/ALXGA1-XAS MULTIPLE-QUANTUM WELLS UNDER INPLANE UNIAXIAL STRAIN SO SURFACE SCIENCE LA English DT Article; Proceedings Paper CT 10th International Conference on Electronic Properties of Two-Dimensional Systems (EP2DS-10) CY MAY 31-JUN 04, 1993 CL NEWPORT, RI SP USA, RES OFF, NATL SCI FDN, USN, OFF NAVAL RES, SUNY BUFFALO, DEPT PHYS & ASTRON, BROWN UNIV, CTR ADV MAT RES ID GAAS; DYNAMICS AB The pump-probe technique was employed in the study of excitonic optical non-linearities at 40 K in a GaAs/Al0.1Ga0.9As multiple quantum well under thermally induced in-plane uniaxial strain. We report the first observation of an ultrafast large-angle polarization rotation of the probe light effected by the bleaching of the anisotropic absorption near the heavy hole exciton peak in this material. Dynamic rotations as large as 42-degrees have been measured for a compressive strain of approximately 0.2%. In addition, a dependence of the phase space filling produced by resonantly excited excitons on the orientation of the pump polarization vector has been observed which decays with a time constant of 0.5 ps. This decay is attributed to the ionization of excitons into free electron-hole pairs. The subsequent decline of the probe rotation is governed by the removal of these carriers from the wells. C1 RUTGERS STATE UNIV,DEPT ELECT & COMP ENGN,PISCATAWAY,NJ 08855. RP WRABACK, M (reprint author), USA,RES LAB,EF,EP,AMSRL,FT MONMOUTH,NJ 07703, USA. RI Schaff, William/B-5839-2009 NR 11 TC 17 Z9 17 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0039-6028 J9 SURF SCI JI Surf. Sci. PD MAR 20 PY 1994 VL 305 IS 1-3 BP 238 EP 242 DI 10.1016/0039-6028(94)90892-3 PG 5 WC Chemistry, Physical; Physics, Condensed Matter SC Chemistry; Physics GA ND674 UT WOS:A1994ND67400043 ER PT J AU RUDIN, S REINECKE, TL AF RUDIN, S REINECKE, TL TI PLASMONS LOCALIZED AT POINT CHARGES IN SEMICONDUCTOR QUANTUM-WELLS SO SURFACE SCIENCE LA English DT Article AB The plasmon excitations of inhomogeneous carrier gases in semiconductor quantum wells in the presence of point charge impurities are investigated. The random phase approximation for the carrier gas yields an integral equation which expresses the condition that plasmons may be self-consistently localized in the vicinity of the impurity. The localized plasmon is a density wave trapped at the impurity site and exists in the electron (hole) gas only for negative (positive) impurity charge. Bound states of the intersubband plasmon are found for all densities of the carrier gas in a quantum well, a result which differs qualitatively from the bulk case. Numerical results for the binding energies are given for a range of relevant parameters. C1 USN, RES LAB, WASHINGTON, DC 20375 USA. RP USA, RES LAB, FT MONMOUTH, NJ 07703 USA. NR 5 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0039-6028 EI 1879-2758 J9 SURF SCI JI Surf. Sci. PD MAR 20 PY 1994 VL 305 IS 1-3 BP 267 EP 270 DI 10.1016/0039-6028(94)90898-2 PG 4 WC Chemistry, Physical; Physics, Condensed Matter SC Chemistry; Physics GA ND674 UT WOS:A1994ND67400049 ER PT J AU BASKIN, SI NEALLEY, EW LEMPKA, JC LEE, RB AF BASKIN, SI NEALLEY, EW LEMPKA, JC LEE, RB TI THE EFFECT OF A LONG-ACTING DIETHYLAMINE NITRIC-OXIDE (DEA NO) COMPLEX ON CYANIDE TOXICITY SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,CHEM DEF RES INST,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 18 PY 1994 VL 8 IS 5 BP A614 EP A614 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA ND197 UT WOS:A1994ND19700170 ER PT J AU BURLESON, DG CIOFFI, WG MASON, AD PRUITT, BA AF BURLESON, DG CIOFFI, WG MASON, AD PRUITT, BA TI ANTIGEN EXPRESSION OF LYMPHOID-CELLS IN BURNED AND TOPIC EPIDERMAL NECROLYSIS (TEN) PATIENTS SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,INST SURG RES,SAN ANTONIO,TX. TRINITY UNIV,SAN ANTONIO,TX. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 18 PY 1994 VL 8 IS 5 BP A752 EP A752 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA ND197 UT WOS:A1994ND19700971 ER EF