FN Thomson Reuters Web of Science™ VR 1.0 PT J AU PETERS, W ROBINSON, BL MILHOUS, WK AF PETERS, W ROBINSON, BL MILHOUS, WK TI THE CHEMOTHERAPY OF RODENT MALARIA .51. STUDIES ON A NEW 8-AMINOQUINOLINE, WR-238,605 SO ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY LA English DT Article ID PLASMODIUM; RESISTANCE; REVERSAL C1 WALTER REED ARMY INST RES,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307. RP PETERS, W (reprint author), CAB INT INST PARASITOL,395A HATFIELD RD,ST ALBANS AL4 0XU,ENGLAND. NR 13 TC 49 Z9 49 U1 0 U2 1 PU CARFAX PUBL CO PI ABINGDON PA PO BOX 25, ABINGDON, OXFORDSHIRE, ENGLAND OX14 3UE SN 0003-4983 J9 ANN TROP MED PARASIT JI Ann. Trop. Med. Parasitol. PD DEC PY 1993 VL 87 IS 6 BP 547 EP 552 PG 6 WC Public, Environmental & Occupational Health; Parasitology; Tropical Medicine SC Public, Environmental & Occupational Health; Parasitology; Tropical Medicine GA MQ515 UT WOS:A1993MQ51500001 PM 8122915 ER PT J AU ESTRELLA, MR BRUSSEAU, ML MAIER, RS PEPPER, IL WIERENGA, PJ MILLER, RM AF ESTRELLA, MR BRUSSEAU, ML MAIER, RS PEPPER, IL WIERENGA, PJ MILLER, RM TI BIODEGRADATION, SORPTION, AND TRANSPORT OF 2,4-DICHLOROPHENOXYACETIC ACID IN SATURATED AND UNSATURATED SOILS SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY LA English DT Article ID XENOBIOTIC COMPOUNDS; DEGRADATION; KINETICS; AQUIFER; SYSTEMS; MODEL AB The fate of an organic contaminant in soil depends on many factors, including sorption, biodegradation, and transport. The herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) was used as a model compound to illustrate the impact of these interacting factors on the fate of an organic contaminant. Batch and column experiments performed with a sandy loam soil mixture under saturated and unsaturated conditions were used to determine the effects of sorption and biodegradation on the fate and transport of 2,4-D. Sorption of 2,4-D was found to have a slight but significant effect on transport of 2,4-D under saturated conditions (retardation factor, 1.8) and unsaturated conditions (retardation factor, 3.4). Biodegradation of 2,4-D was extensive under both batch and column conditions and was found to have a significant impact on 2,4-D transport in column experiments. In batch experiments, complete mineralization of 2,4-D (100 mg kg-1) occurred over a 4-day period following a 3-day lag phase under both saturated and unsaturated conditions. The biodegradation rate parameters calculated for batch experiments were found to be significantly different from those estimated for column experiments. C1 UNIV ARIZONA,DEPT SOIL & WATER SCI,TUCSON,AZ 85721. UNIV MINNESOTA,ARMY HIGH PERFORMANCE COMP RES CTR,MINNEAPOLIS,MN 55415. FU NIEHS NIH HHS [IP42ES4940] NR 20 TC 76 Z9 78 U1 0 U2 7 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0099-2240 J9 APPL ENVIRON MICROB JI Appl. Environ. Microbiol. PD DEC PY 1993 VL 59 IS 12 BP 4266 EP 4273 PG 8 WC Biotechnology & Applied Microbiology; Microbiology SC Biotechnology & Applied Microbiology; Microbiology GA MK854 UT WOS:A1993MK85400040 PM 8285717 ER PT J AU SHLECHTER, TM AF SHLECHTER, TM TI COMPUTER-BASED INSTRUCTION AND THE PRACTICAL ASPECTS OF MEMORY SO APPLIED COGNITIVE PSYCHOLOGY LA English DT Article; Proceedings Paper CT 1992 Annual Meeting of the Association-for-Development-of-Computer-Assisted-Instruction CY NOV 08-12, 1992 CL ATLANTA, GA SP ASSOC DEV COMP ASSISTED INSTRUCT ID ENVIRONMENTS; SIMULATIONS; RECALL; MEDIA AB This article examines the relationship between basic memory research and computer-based instruction (CBI). The results of basic memory research have helped determine the current directions of computer-assisted instruction (CAI) research and development. These directions have included examining the utility of such learning systems for facilitating memory outcomes and developing CBI systems based on cognitive instructional principles. Examples of such systems include the emerging generation of hypermedia and artificial tutoring systems. Inconclusive results, however, have been found regarding CBI's effects on memory phenomena. The CBI literature has thus not established the utility of any memory theory for naturally occurring phenomena. Several plausible reasons for this 'null finding' are discussed. RP SHLECHTER, TM (reprint author), USA,RES INST,BLDG 2433,FT KNOX,KY 40121, USA. NR 58 TC 2 Z9 2 U1 0 U2 0 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0888-4080 J9 APPL COGNITIVE PSYCH JI Appl. Cogn. Psychol. PD DEC PY 1993 VL 7 IS 7 BP 653 EP 664 DI 10.1002/acp.2350070708 PG 12 WC Psychology, Experimental SC Psychology GA MT356 UT WOS:A1993MT35600007 ER PT J AU BEARD, JS BENSON, PM SKILLMAN, L AF BEARD, JS BENSON, PM SKILLMAN, L TI RAPID DIAGNOSIS OF COCCIDIOIDOMYCOSIS WITH A DNA-PROBE TO RIBOSOMAL-RNA SO ARCHIVES OF DERMATOLOGY LA English DT Article ID IDENTIFICATION AB Background: Although nucleic acid probe hybridization assays were previously exclusively used as a tool in the research setting, such assays have recently become commercially available for the detection of a variety of infectious microorganisms. Observations: We used a commercially available DNA hybridization probe test that targets organism-specific ribosomal RNA sequences to rapidly diagnose a patient with disseminated coccidioidomycosis. The natural amplification inherent to such DNA:RNA probe systems obviates the need for electrophoretic separation and amplification steps, which are often required in more traditional DNA:DNA probe assays. With this probe, culture confirmation obtained within 48 hours after the clinical specimens were received. Conclusion: Rapid DNA hybridization probe techniques have wide application in infectious diseases, especially those characterized by slow culture growth of pathogens such as deep fungi and atypical mycobacteria. C1 WALTER REED ARMY MED CTR,DEPT PATHOL,WASHINGTON,DC 20307. RP BEARD, JS (reprint author), WALTER REED ARMY MED CTR,DERMATOL SERV,WASHINGTON,DC 20307, USA. NR 17 TC 8 Z9 8 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0003-987X J9 ARCH DERMATOL JI Arch. Dermatol. PD DEC PY 1993 VL 129 IS 12 BP 1589 EP 1593 DI 10.1001/archderm.129.12.1589 PG 5 WC Dermatology SC Dermatology GA MW826 UT WOS:A1993MW82600007 PM 8250580 ER PT J AU SCHWAB, RA GIBLIN, WJ JAMES, WD LUPTON, GP AF SCHWAB, RA GIBLIN, WJ JAMES, WD LUPTON, GP TI MULTIPLE CUTANEOUS ULCERATIONS - CUTANEOUS ULCERATIONS IN CROHNS-DISEASE (METASTATIC CROHNS-DISEASE) SO ARCHIVES OF DERMATOLOGY LA English DT Note C1 WALTER REED ARMY MED CTR,WASHINGTON,DC. ARMED FORCES INST PATHOL,WASHINGTON,DC. RP SCHWAB, RA (reprint author), WALSON ARMY COMMUNITY HOSP,FT DIX,NJ 08640, USA. NR 9 TC 11 Z9 11 U1 0 U2 1 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0003-987X J9 ARCH DERMATOL JI Arch. Dermatol. PD DEC PY 1993 VL 129 IS 12 BP 1607 EP & PG 0 WC Dermatology SC Dermatology GA MW826 UT WOS:A1993MW82600010 PM 8250582 ER PT J AU ROTHBERG, JM AF ROTHBERG, JM TI BATTLE EXHAUSTION - SOLDIERS AND PSYCHIATRISTS IN THE CANADIAN ARMY, 1939-1945 - COPP,T, MCANDREW,B SO ARMED FORCES & SOCIETY LA English DT Book Review RP ROTHBERG, JM (reprint author), WALTER REED ARMY INST RES,DEPT MIL PSYCHIAT,WASHINGTON,DC 20307, USA. NR 2 TC 0 Z9 0 U1 0 U2 0 PU TRANSACTION PERIOD CONSORTIUM PI NEW BRUNSWICK PA DEPT 3091 RUTGERS-THE STATE UNIV OF NJ, NEW BRUNSWICK, NJ 08903 SN 0095-327X J9 ARMED FORCES SOC JI Armed Forces Soc. PD WIN PY 1993 VL 19 IS 2 BP 298 EP 300 DI 10.1177/0095327X9301900211 PG 3 WC Political Science; Sociology SC Government & Law; Sociology GA KP406 UT WOS:A1993KP40600010 ER PT J AU CORNUM, RLS CALDWELL, JL LUDWICK, R AF CORNUM, RLS CALDWELL, JL LUDWICK, R TI FACTORS INFLUENCING SUCCESS OR FAILURE IN THE AH-64 COURSE SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article AB A greater percentage of qualified student pilots fail the AH-64 (Apache) transition than any other advanced aircraft transition in the Army. We studied 140 consecutive students presenting for training in an effort to identify factors which might predict success or failure in the AH-64 course, Questionnaires were used to elicit demographic, anxiety level, and motion sickness history information prior to beginning Apache flight training. Motion sickness symptoms (MSS) during the enclosed cockpit, or ''bag,'' phase of training were quantified using pre- and postbag flight symptom questionnaires. Performance measures included grades and flight hours required to pass the course. Only one piece of information obtained prior to flight training was related to performance in the AH-64 course; i.e., students who requested the transition performed measurably better than students who did not. While 7% of pilots described significant MSS on the first day of enclosed cockpit flight, this decreased to 2% by day 5. Severity of symptoms during bag phase was not related to any measure of subsequent performance. C1 USA,AEROMED RES LAB,DIV BIOMED APPLICAT RES,FT RUCKER,AL 36362. NR 6 TC 0 Z9 0 U1 0 U2 0 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD DEC PY 1993 VL 64 IS 12 BP 1120 EP 1124 PG 5 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA MK441 UT WOS:A1993MK44100007 PM 8291992 ER PT J AU KRISHNA, S TERKUILE, F SUPANARANOND, W PUKRITTAYAKAMEE, S TEJAISAVADHARM, P KYLE, D WHITE, NJ AF KRISHNA, S TERKUILE, F SUPANARANOND, W PUKRITTAYAKAMEE, S TEJAISAVADHARM, P KYLE, D WHITE, NJ TI PHARMACOKINETICS, EFFICACY AND TOXICITY OF PARENTERAL HALOFANTRINE IN UNCOMPLICATED MALARIA SO BRITISH JOURNAL OF CLINICAL PHARMACOLOGY LA English DT Article DE HALOFANTRINE, PARENTERAL; UNCOMPLICATED PLASMODIUM-FALCIPARUM; PHARMACOKINETICS; ANTIMALARIAL; MALARIA; MALARIA, TREATMENT ID FALCIPARUM-MALARIA; DESBUTYLHALOFANTRINE AB 1 The pharmacokinetics, efficacy and toxicity of a new parenteral formulation of halofantrine hydrochloride were evaluated in 12 adults with acute uncomplicated falciparum malaria and nine adults who attended in convalescence. 2 Intravenous halofantrine (1 mg kg-1 infused in 1 h) was given every 8 h for a total of three doses in the acute study. Halofantrine cleared parasitaemia rapidly in all but one patient, with a mean (s.d.) parasite clearance time of 71 (29) h. Convalescent patients received a single infusion (1 mg kg-1 in 1 h). 3 An open two-compartment model with the following parameters described the pharmacokinetics of halofantrine in acute malaria (mean (s.d)): V1 = 0.36 (0.18) 1 kg-1; CL = 0.355 (0.18) 1 h-1 kg-1; t1/2alpha = 0.19 (0.12) h; t1/2beta = 14.4 (7.5) h. 4 Intravenous halofantrine in acute malaria produced significant prolongations of the QT and QT(c) intervals (mean (s.d.)) of 20 (15%) and 8.2 (5.6)%, respectively (P < 0.001) after the third dose, but no clinically significant cardiotoxcity. Eight patients experienced mild to moderate thrombophlebitis at the halofantrine infusion site which had resolved in six by the time of follow-up. In the single treatment failure who received oral quinine, there was a large rise in plasma halofantrine concentration but this did not result in detectable toxicity. 5 These data provide the basis for the design of improved dosing regiment for the use of parenteral halofantrine in malaria. C1 MAHIDOL UNIV,FAC TROP MED,BANGKOK 10400,THAILAND. JOHN RADCLIFFE HOSP,NUFFIELD DEPT CLIN MED,OXFORD OX3 9DU,ENGLAND. UNIV AMSTERDAM,ACAD MED CTR,INFECT DIS & TROP MED UNIT,1105 AZ AMSTERDAM,NETHERLANDS. US ARMED FORCES MED RES INST,US ARMY MED COMPONENT,DEPT IMMUNOL & BIOCHEM,BANGKOK 96546,THAILAND. RI White, Nicholas/I-4629-2012; OI Krishna, Sanjeev/0000-0003-0066-0634 FU Wellcome Trust NR 13 TC 27 Z9 28 U1 3 U2 4 PU BLACKWELL SCIENCE LTD PI OXFORD PA OSNEY MEAD, OXFORD, OXON, ENGLAND OX2 0EL SN 0306-5251 J9 BRIT J CLIN PHARMACO JI Br. J. Clin. Pharmacol. PD DEC PY 1993 VL 36 IS 6 BP 585 EP 591 PG 7 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA ML467 UT WOS:A1993ML46700012 PM 12959277 ER PT J AU BRANNON, JM PRICE, CB REILLY, FJ PENNINGTON, JC MCFARLAND, VA AF BRANNON, JM PRICE, CB REILLY, FJ PENNINGTON, JC MCFARLAND, VA TI EFFECTS OF SEDIMENT ORGANIC-CARBON ON DISTRIBUTION OF RADIOLABELED FLUORANTHENE AND PCBS AMONG SEDIMENT, INTERSTITIAL WATER, AND BIOTA SO BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY LA English DT Article ID POLYCHLORINATED BIPHENYL CONGENERS; SOILS; SORPTION C1 ASCL CORP,VICKSBURG,MS 39180. RP BRANNON, JM (reprint author), USA,ENGINEER WATERWAYS EXPT STN,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 20 TC 15 Z9 15 U1 0 U2 0 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0007-4861 J9 B ENVIRON CONTAM TOX JI Bull. Environ. Contam. Toxicol. PD DEC PY 1993 VL 51 IS 6 BP 873 EP 880 PG 8 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA MB246 UT WOS:A1993MB24600014 PM 8257815 ER PT J AU YANKIELUN, NE FERRICK, MG WEYRICK, PB AF YANKIELUN, NE FERRICK, MG WEYRICK, PB TI DEVELOPMENT OF AN AIRBORNE MILLIMETER-WAVE FM-CW RADAR FOR MAPPING RIVER ICE SO CANADIAN JOURNAL OF CIVIL ENGINEERING LA English DT Article DE AIRBORNE; FM-CW RADAR; HIGH-RESOLUTION RADAR; ICE PROFILING; MILLIMETER WAVES; RADAR REMOTE SENSING; RIVER ICE ID THICKNESS AB Analyses of a river's freezeup ice cover stability and its breakup rely on detailed knowledge of the cover's thickness and the variability of that thickness. A high-resolution, millimeter wave (26.5- to 40-GHz) frequency modulated-continuous wave radar with real-time data acquisition and digital signal processing and display capability was deployed from a low-flying (3-10 m) helicopter to continuously acquire, process, and display data during an ice thickness profiling survey of a 24-km study reach. A nominal sheet ice thickness of 50 cm, occasional areas of new ice sheet as thin as 5 cm, open leads, and massive ice accumulations of the order of 5 m thick were encountered. Radar profiling data agreed with ground truth from borehole measurements of the sheet ice, and provided a more detailed view of the ice conditions than that obtained from a low altitude video survey. The radar system provided rapid, safe, and accurate data acquisition, allowing detailed mapping of the ice conditions throughout the reach. RP YANKIELUN, NE (reprint author), USA CORPS ENGINEERS,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 18 TC 3 Z9 3 U1 0 U2 1 PU NATL RESEARCH COUNCIL CANADA PI OTTAWA PA RESEARCH JOURNALS, MONTREAL RD, OTTAWA ON K1A 0R6, CANADA SN 0315-1468 J9 CAN J CIVIL ENG JI Can. J. Civ. Eng. PD DEC PY 1993 VL 20 IS 6 BP 1057 EP 1064 PG 8 WC Engineering, Civil SC Engineering GA MR117 UT WOS:A1993MR11700016 ER PT J AU MARCUSON, WF HADALA, PF LEDBETTER, RH AF MARCUSON, WF HADALA, PF LEDBETTER, RH TI SEISMIC REMEDIATION FOR EARTH DAMS SO CIVIL ENGINEERING LA English DT Article C1 CORPS DIRECTORATE CIVIL WORKS,DIV ENGN,WASHINGTON,DC. RP MARCUSON, WF (reprint author), USA,GEOTECH LAB,ENGN WATERWAYS EXPT STN,VICKSBURG,MS 39180, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASCE-AMER SOC CIVIL ENGINEERS PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0885-7024 J9 CIVIL ENG JI Civil Eng. PD DEC PY 1993 VL 63 IS 12 BP 76 EP 78 PG 3 WC Engineering, Civil SC Engineering GA MK780 UT WOS:A1993MK78000036 ER PT J AU LOUBE, DI PEACOCK, MD BLANTON, HM MORALES, ML EPSTEIN, LJ STROLLO, PJ AF LOUBE, DI PEACOCK, MD BLANTON, HM MORALES, ML EPSTEIN, LJ STROLLO, PJ TI A COMPARISON OF SELF-REPORTED SLEEPINESS AND SNORING IN PREGNANT AND NONPREGNANT WOMEN SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 BROOKE ARMY MED CTR, DEPT PULM, FT SAM HOUSTON, TX 78234 USA. BROOKE ARMY MED CTR, DEPT OBSTET, FT SAM HOUSTON, TX 78234 USA. WILFORD HALL USAF MED CTR, DEPT PULM, LACKLAND AFB, TX 78236 USA. UNIV PITTSBURGH, DIV PULM ALLERGY & CRIT CARE, PITTSBURGH, PA 15260 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0009-9279 J9 CLIN RES JI Clin. Res. PD DEC PY 1993 VL 41 IS 4 BP A737 EP A737 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA MN948 UT WOS:A1993MN94800120 ER PT J AU LOUBE, DI EPSTEIN, IJ DAVENPORT, WL STROLLO, PJ AF LOUBE, DI EPSTEIN, IJ DAVENPORT, WL STROLLO, PJ TI ASSESSMENT OF THE VARIABILITY IN CEPHALOMETRIC ROENTGENOGRAM MEASUREMENTS DURING QUIET TIDAL BREATHING IN NORMALS AND OBSTRUCTIVE SLEEP-APNEA PATIENTS SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 BROOKE ARMY MED CTR, DEPT PULM & CRIT CARE, FT SAM HOUSTON, TX 78234 USA. WILFORD HALL USAF MED CTR, DEPT PULM & CRIT CARE, LACKLAND AFB, TX 78236 USA. WILFORD HALL USAF MED CTR, DEPT ORAL SURG, LACKLAND AFB, TX 78236 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0009-9279 J9 CLIN RES JI Clin. Res. PD DEC PY 1993 VL 41 IS 4 BP A737 EP A737 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA MN948 UT WOS:A1993MN94800117 ER PT J AU LOUBE, DI ANDRADE, F ANZUETO, A LEVINE, SM MAXWELL, L LAWRENCE, R NAPIER, W JENKINSON, SG AF LOUBE, DI ANDRADE, F ANZUETO, A LEVINE, SM MAXWELL, L LAWRENCE, R NAPIER, W JENKINSON, SG TI LEUKOCYTE DEPLETION DOES NOT ATTENUATE DIAPHRAGM MUSCLE IMPAIRMENT AFTER INSPIRATORY RESISTIVE LOADING (IRL) SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 UNIV TEXAS,HLTH SCI CTR,DEPT MED,SAN ANTONIO,TX 78284. UNIV TEXAS,HLTH SCI CTR,DEPT PHYSIOL,SAN ANTONIO,TX 78284. BROOKE ARMY MED CTR,DEPT PULM,FT SAM HOUSTON,TX 78234. RI Andrade, Francisco/F-1258-2011 OI Andrade, Francisco/0000-0002-2460-5798 NR 1 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 SN 0009-9279 J9 CLIN RES JI Clin. Res. PD DEC PY 1993 VL 41 IS 4 BP A776 EP A776 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA MN948 UT WOS:A1993MN94800327 ER PT J AU BEACHY, JC WEISMAN, LE AF BEACHY, JC WEISMAN, LE TI ACUTE ASPHYXIA AFFECTS NEUTROPHIL NUMBER AND FUNCTION IN THE RAT SO CRITICAL CARE MEDICINE LA English DT Article DE NEUTROPHILS; HYPERCARBIA; ACIDOSIS; ASPHYXIA; SHOCK; SEPTIC; PHAGOCYTOSIS; PHYSIOLOGY; BACTERIAL INFECTION; CRITICAL ILLNESS; HYPOTHERMIA; STRESS ID B STREPTOCOCCAL DISEASE; NEWBORN-INFANTS; INVITRO; HEALTHY; PHAGOCYTOSIS; DYSFUNCTION; LEUKOCYTES; RECEPTORS; GLOBULIN; NEONATE AB Objectives: Previous studies in adults suggest that various types of physiologic stress appear to decrease phagocytic cell function. Adherence and chemotaxis of, and phagocytosis and bacterial killing by, neonatal neutrophils are altered compared with adult neutrophil function. Stresses encountered by the fetus and neonate, such as asphyxia, were hypothesized to further alter neonatal neutrophil function. To investigate the impact of asphyxia on systemic immunity, we developed a rat model of acute asphyxia and evaluated the effect of asphyxia on neutrophil number and function. Design: Prospective, laboratory study. Setting: Research laboratory. Subjects: Adult female Wistar rats. Interventions: Exposure to CO2 and cold stress. Measurements and Main Results: Arterial blood gas, blood glucose, neutrophil number, neutrophil-mediated, complement-dependent bacterial phagocytosis and killing were determined. After a 20-sec exposure to CO2 and cold stress (dry ice vapors), adult rats developed acute respiratory acidosis (pH 6.89 +/- 0.26, Paco(2) 220 +/- 183 torr [29.3 +/- 24.3 kPa]), and mild hypoxia (60 +/- 20 torr [8.0 +/- 2.7 kPa]) followed by significant metabolic acidosis (base deficit = -12.0 +/- 1.5). Neutrophil number slowly increased and reached statistical significance by 72 hrs (5.0 +/- 1.5 x 10(3)/ mm(3)) compared to controls (2.9 +/- 1.6 x 10(3)/mm(3)) (p =.03). Phagocytosis and killing of group B streptococci by neutrophils isolated immediately after asphyxia were significantly impaired (p =.03), and this decrease in function lasted for 24 hrs after asphyxia (p =.04), as measured by two different in vitro complement and antibody-mediated functional assays. Conclusions: After brief exposure to CO2 and cold stress, rats developed an acute respiratory acidosis and subsequent metabolic acidosis similar to acute asphyxia. Neutrophil number did not increase until 72 hrs after asphyxia. However, neutrophil-mediated phagocytosis and killing of bacteria were immediately impaired. We speculate that asphyxia may increase the risk for sepsis secondary to altered neutrophil function. C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. RP BEACHY, JC (reprint author), UNIFORMED SERV UNIV HLTH SCI,DEPT PEDIAT,BETHESDA,MD 20814, USA. NR 32 TC 15 Z9 15 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD DEC PY 1993 VL 21 IS 12 BP 1929 EP 1934 DI 10.1097/00003246-199312000-00022 PG 6 WC Critical Care Medicine SC General & Internal Medicine GA MK608 UT WOS:A1993MK60800022 PM 8252900 ER PT J AU BURCH, HB WARTOFSKY, L AF BURCH, HB WARTOFSKY, L TI GRAVES OPHTHALMOPATHY - CURRENT CONCEPTS REGARDING PATHOGENESIS AND MANAGEMENT SO ENDOCRINE REVIEWS LA English DT Review ID THYROID-ASSOCIATED OPHTHALMOPATHY; DYSTHYROID OPTIC NEUROPATHY; HUMAN THYROTROPIN RECEPTOR; SUPERVOLTAGE ORBITAL RADIOTHERAPY; HUMAN RETROOCULAR FIBROBLASTS; HEAT-SHOCK PROTEIN; HUMAN-EYE MUSCLE; HLA-DR ANTIGEN; METHYLPREDNISOLONE PULSE THERAPY; LINKED IMMUNOSORBENT-ASSAY C1 WALTER REED ARMY MED CTR,DEPT MED,KYLE METAB UNIT,ENDOCRINE METAB SERV,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. NR 508 TC 391 Z9 412 U1 0 U2 7 PU ENDOCRINE SOC PI BETHESDA PA 4350 EAST WEST HIGHWAY SUITE 500, BETHESDA, MD 20814-4110 SN 0163-769X J9 ENDOCR REV JI Endocr. Rev. PD DEC PY 1993 VL 14 IS 6 BP 747 EP 793 DI 10.1210/er.14.6.747 PG 47 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA MN683 UT WOS:A1993MN68300006 PM 8119236 ER PT J AU YANG, SH THEDREZ, BJ SADDOW, SE WOOD, C WILSON, R LEE, CH AF YANG, SH THEDREZ, BJ SADDOW, SE WOOD, C WILSON, R LEE, CH TI CROSS-CORRELATION MEASUREMENT OF THE TURN-ON DELAY AND PULSEWIDTH OF A Q-SWITCHED 2-SECTION SEMICONDUCTOR-LASER SO IEEE PHOTONICS TECHNOLOGY LETTERS LA English DT Article ID QUANTUM-WELL LASERS; GENERATION AB Cross-correlation techniques were employed for direct optical measurement of a Q-switched two-section semiconductor laser output versus electrical bias. Since our switching scheme is not limited by external connections to the device, the ultrafast dynamics of the diode laser can be investigated. In particular, a turn-on delay as small as 70 ps was recorded with picosecond accuracy. In addition, the FWHM and peak power of the Q-switched pulse were also measured. A numerical simulation was performed, and good agreement with experimental results was achieved. C1 USA,RES LAB,ADELPHI,MD 20783. LAB PHYS SCI,COLL PK,MD 20742. RP YANG, SH (reprint author), UNIV MARYLAND,DEPT ELECT ENGN,COLL PK,MD 20742, USA. NR 12 TC 0 Z9 1 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 1041-1135 J9 IEEE PHOTONIC TECH L JI IEEE Photonics Technol. Lett. PD DEC PY 1993 VL 5 IS 12 BP 1365 EP 1368 PG 4 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA MW666 UT WOS:A1993MW66600005 ER PT J AU KINGSLEY, LE DONALDSON, WR AF KINGSLEY, LE DONALDSON, WR TI NUMERICAL-ANALYSIS OF ELECTRIC-FIELD PROFILES IN HIGH-VOLTAGE GAAS PHOTOCONDUCTIVE SWITCHES AND COMPARISON TO EXPERIMENT SO IEEE TRANSACTIONS ON ELECTRON DEVICES LA English DT Article AB The electric field in GaAs photoconductive switches has been observed with an ultrafast electro-optic imaging system to develop complex spatial and temporal structure immediately after illumination. High-field domains form at the switch cathode as the photogenerated carriers recombine for bias fields above similar to 10 kV/cm. At these biases, the switch also remained conductive for a much longer time (similar to 100 ns) than the material recombination time (similar to 1 ns). A model which includes field-dependent mobility was developed to explain this data. Simulation of the electric field profile across the switch indicates that high-field domains which form at the switch cathode are the result of negative differential resistance. C1 UNIV ROCHESTER,LASER ENERGET LAB,ROCHESTER,NY 14623. UNIV ROCHESTER,ULTRAFAST SCI GRP,ROCHESTER,NY. RP KINGSLEY, LE (reprint author), USA,RES LAB,CTR PULSE POWER,AMSRL,EP,MC,FT MONMOUTH,NJ 07703, USA. NR 28 TC 10 Z9 12 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9383 J9 IEEE T ELECTRON DEV JI IEEE Trans. Electron Devices PD DEC PY 1993 VL 40 IS 12 BP 2344 EP 2351 DI 10.1109/16.249485 PG 8 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA MP363 UT WOS:A1993MP36300027 ER PT J AU LELIS, AJ OLDHAM, TR AF LELIS, AJ OLDHAM, TR TI RELIABILITY EFFECTS OF X-RAY-LITHOGRAPHY EXPOSURES ON SUBMICRON-CHANNEL MOSFETS SO IEEE TRANSACTIONS ON NUCLEAR SCIENCE LA English DT Article; Proceedings Paper CT IEEE 30th Annual International Nuclear and Space Radiation Effects Conference (NSREC) CY JUL 19-23, 1993 CL SNOWBIRD, UT SP IEEE, NUCL & PLASMA SCI SOC, RADIAT EFFECTS COMM, US DEPT DEF, DEF NUCL AGCY, US DEF ENERGY ENERGY, SANDIA NATL LAB, NASA, JET PROPULS LAB ID INDUCED INSTABILITY; GENERATION AB Submicron-channel-length n- and p-channel MOSFETs subjected to channel hot-carrier stressing were investigated, and the reliability of devices with and without exposure to simulated x-ray lithography processing steps was compared. No significant differences were observed between the sample groups. RP LELIS, AJ (reprint author), USA,RES LAB,2800 POWDER MILL RD,ADELPHI,MD 20783, USA. NR 18 TC 5 Z9 5 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9499 J9 IEEE T NUCL SCI JI IEEE Trans. Nucl. Sci. PD DEC PY 1993 VL 40 IS 6 BP 1367 EP 1371 DI 10.1109/23.273530 PN 1 PG 5 WC Engineering, Electrical & Electronic; Nuclear Science & Technology SC Engineering; Nuclear Science & Technology GA MV375 UT WOS:A1993MV37500014 ER PT J AU MILLER, RB MCCULLOUGH, WF MERKEL, G LITZ, M ROBERTS, H SMITH, M STILL, GW AF MILLER, RB MCCULLOUGH, WF MERKEL, G LITZ, M ROBERTS, H SMITH, M STILL, GW TI RISETIME SHARPENING USING MAGNETIC INSULATION IN THE AURORA DIODE SO IEEE TRANSACTIONS ON NUCLEAR SCIENCE LA English DT Article; Proceedings Paper CT IEEE 30th Annual International Nuclear and Space Radiation Effects Conference (NSREC) CY JUL 19-23, 1993 CL SNOWBIRD, UT SP IEEE, NUCL & PLASMA SCI SOC, RADIAT EFFECTS COMM, US DEPT DEF, DEF NUCL AGCY, US DEF ENERGY ENERGY, SANDIA NATL LAB, NASA, JET PROPULS LAB ID BREMSSTRAHLUNG AB Theoretical calculations indicate that Aurora diode geometrical reconfigurations that delay the onset of magnetic insulation should yield a decreased risetime. Experimentally these diode modifications have resulted in a decrease of the beam risetime from approximately 80 ns to 20 ns. C1 USA,RES LAB,ADELPHI,MD 20783. RP MILLER, RB (reprint author), TITAN,SPECTRON DEV LABS,2309 RENARD SE,ALBUQUERQUE,NM 87106, USA. NR 11 TC 2 Z9 2 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9499 J9 IEEE T NUCL SCI JI IEEE Trans. Nucl. Sci. PD DEC PY 1993 VL 40 IS 6 BP 1426 EP 1433 DI 10.1109/23.273522 PN 1 PG 8 WC Engineering, Electrical & Electronic; Nuclear Science & Technology SC Engineering; Nuclear Science & Technology GA MV375 UT WOS:A1993MV37500022 ER PT J AU MERKEL, G LITZ, M ROBERTS, H SMITH, M STILL, GW MILLER, RB MCCULLOUGH, WF AF MERKEL, G LITZ, M ROBERTS, H SMITH, M STILL, GW MILLER, RB MCCULLOUGH, WF TI BEHAVIOR OF A RELATIVISTIC ELECTRON-BEAM IN A GAS-FILLED DRIFT-TUBE AS A FUNCTION OF GAS-PRESSURE SO IEEE TRANSACTIONS ON NUCLEAR SCIENCE LA English DT Article; Proceedings Paper CT IEEE 30th Annual International Nuclear and Space Radiation Effects Conference (NSREC) CY JUL 19-23, 1993 CL SNOWBIRD, UT SP IEEE, NUCL & PLASMA SCI SOC, RADIAT EFFECTS COMM, US DEPT DEF, DEF NUCL AGCY, US DEF ENERGY ENERGY, SANDIA NATL LAB, NASA, JET PROPULS LAB ID BREMSSTRAHLUNG AB Several issues pertaining to electron beam propagation and techniques for risetime enhancement of the Aurora electron beam and bremsstrahlung pulses are examined. Time-varying models for the double-humped current waveforms produced by propagating relativistic electron beams through gas cells of various pressures and gas species are developed and compared with experimental results. Specifically, there is a pressure region in which the electron beam propagates until a virtual cathode is formed. At later times the virtual cathode is neutralized by the formation of positive ions by collisions between gas molecules and relativistic electrons. The beam can then propagate, C1 TITAN,SPECTRON DEV LABS,ALBUQUERQUE,NM 87106. RP MERKEL, G (reprint author), USA,RES LAB,2800 POWDER MILL RD,ADELPHI,MD 20783, USA. NR 10 TC 7 Z9 7 U1 1 U2 2 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9499 J9 IEEE T NUCL SCI JI IEEE Trans. Nucl. Sci. PD DEC PY 1993 VL 40 IS 6 BP 1434 EP 1441 DI 10.1109/23.273521 PN 1 PG 8 WC Engineering, Electrical & Electronic; Nuclear Science & Technology SC Engineering; Nuclear Science & Technology GA MV375 UT WOS:A1993MV37500023 ER PT J AU MOORE, RA BENEDETTO, J ROD, BJ AF MOORE, RA BENEDETTO, J ROD, BJ TI TOTAL-DOSE EFFECT ON FERROELECTRIC PZT CAPACITORS USED AS NONVOLATILE STORAGE ELEMENTS SO IEEE TRANSACTIONS ON NUCLEAR SCIENCE LA English DT Article; Proceedings Paper CT IEEE 30th Annual International Nuclear and Space Radiation Effects Conference (NSREC) CY JUL 19-23, 1993 CL SNOWBIRD, UT SP IEEE, NUCL & PLASMA SCI SOC, RADIAT EFFECTS COMM, US DEPT DEF, DEF NUCL AGCY, US DEF ENERGY ENERGY, SANDIA NATL LAB, NASA, JET PROPULS LAB ID RADIATION; MEMORIES AB This paper examines the effects of ionizing radiation on the retained polarization of lead zirconate titanate (PZT) thin films. The retained polarization is the key parameter in measuring the radiation tolerance of the PZT storage element in a non-volatile memory. Data from the retained polarization measurement show a larger radiation-induced degradation than has generally been reported using the traditional hysteresis loop method for:measuring remanent polarization. it appears that the difference is due in part to a cycling-induced annealing effect during the hysteresis loop measurement. RP MOORE, RA (reprint author), USA,RES LAB,ADELPHI,MD 20738, USA. NR 10 TC 28 Z9 29 U1 0 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9499 J9 IEEE T NUCL SCI JI IEEE Trans. Nucl. Sci. PD DEC PY 1993 VL 40 IS 6 BP 1591 EP 1596 DI 10.1109/23.273502 PN 1 PG 6 WC Engineering, Electrical & Electronic; Nuclear Science & Technology SC Engineering; Nuclear Science & Technology GA MV375 UT WOS:A1993MV37500045 ER PT J AU ANDERSON, WT GERDES, J ROUSSOS, JA AF ANDERSON, WT GERDES, J ROUSSOS, JA TI TEMPERATURE-DEPENDENT GAAS MMIC RADIATION EFFECTS SO IEEE TRANSACTIONS ON NUCLEAR SCIENCE LA English DT Article ID FIELD-EFFECT TRANSISTORS; TRANSIENT RADIATION; IONIZING-RADIATION; FETS; CIRCUITS AB The temperature dependence of pulsed neutron and flash x-ray radiation effects was studied in GaAs MMICs. Above room temperature the long term current transients are dominated by electron trapping in previously existing defects. At low temperature in the range 126 to 259 K neutron induced lattice damage appears to play an increasingly important role in producing long term current transients. C1 USA, PULSE RADIAT FACIL, ABERDEEN PROVING GROUND, MD USA. RP USN, RES LAB, CODE 6855, WASHINGTON, DC 20375 USA. NR 19 TC 1 Z9 1 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-9499 EI 1558-1578 J9 IEEE T NUCL SCI JI IEEE Trans. Nucl. Sci. PD DEC PY 1993 VL 40 IS 6 BP 1735 EP 1739 DI 10.1109/23.273485 PN 1 PG 5 WC Engineering, Electrical & Electronic; Nuclear Science & Technology SC Engineering; Nuclear Science & Technology GA MV375 UT WOS:A1993MV37500064 ER PT J AU BOESCH, HE TAYLOR, TL KRULL, WA AF BOESCH, HE TAYLOR, TL KRULL, WA TI CHARGE TRAPPING AND TRANSPORT-PROPERTIES OF SIMOX BURIED OXIDES WITH A SUPPLEMENTAL OXYGEN IMPLANT SO IEEE TRANSACTIONS ON NUCLEAR SCIENCE LA English DT Article; Proceedings Paper CT IEEE 30th Annual International Nuclear and Space Radiation Effects Conference (NSREC) CY JUL 19-23, 1993 CL SNOWBIRD, UT SP IEEE, NUCL & PLASMA SCI SOC, RADIAT EFFECTS COMM, US DEPT DEF, DEF NUCL AGCY, US DEF ENERGY ENERGY, SANDIA NATL LAB, NASA, JET PROPULS LAB ID HOLE TRANSPORT; X-RAY AB The radiation response characteristics of single- and multiple-implant SIMOX (separation by implantation of oxygen) buried oxide layers that had received a supplemental oxygen implant and anneal step were measured as a function of temperature and time after exposure to short radiation pulses. A fast capacitance-voltage technique was used for these measurements. The results indicate that, in comparison to standard SIMOX, the supplemental-implant SIMOX buried oxide shows hole motion through the oxide, greatly reduced bulk hole trapping, and little or no bulk shallow electron trapping. Substantial interfacial hole trapping was observed in these materials, as well as deep electron trapping in the single-implant material. C1 IBIS TECHNOL CORP,DANVERS,MA 01923. RP BOESCH, HE (reprint author), USA,RES LAB,2800 POWDER MILL RD,ADELPHI,MD 20783, USA. NR 17 TC 19 Z9 21 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9499 J9 IEEE T NUCL SCI JI IEEE Trans. Nucl. Sci. PD DEC PY 1993 VL 40 IS 6 BP 1748 EP 1754 DI 10.1109/23.273483 PN 1 PG 7 WC Engineering, Electrical & Electronic; Nuclear Science & Technology SC Engineering; Nuclear Science & Technology GA MV375 UT WOS:A1993MV37500066 ER PT J AU PENNISE, CA BOESCH, HE GOETZ, G MCKITTERICK, JB AF PENNISE, CA BOESCH, HE GOETZ, G MCKITTERICK, JB TI RADIATION-INDUCED CHARGE EFFECTS IN BURIED OXIDES WITH DIFFERENT PROCESSING TREATMENTS SO IEEE TRANSACTIONS ON NUCLEAR SCIENCE LA English DT Article; Proceedings Paper CT IEEE 30th Annual International Nuclear and Space Radiation Effects Conference (NSREC) CY JUL 19-23, 1993 CL SNOWBIRD, UT SP IEEE, NUCL & PLASMA SCI SOC, RADIAT EFFECTS COMM, US DEPT DEF, DEF NUCL AGCY, US DEF ENERGY ENERGY, SANDIA NATL LAB, NASA, JET PROPULS LAB AB We characterize the radiation-induced charge trapping and transport properties of the buried-oxide (BOX) layer using the photocurrent response technique and capacitance-voltage shift measurements for a variety of silicon-on-insulator (SOI) materials. We observe dramatic differences as a result of different BOX processing conditions. The radiation response of the SOI as a whole is shown to be consistent with the basic properties of the material(s) contained in the BOX layer. In comparison to standard separation by implantation of oxygen (SIMOX) material, SIMOX receiving a supplemental oxygen implant and low-temperature anneal produces large normalized photocurrent values indicating that both radiation-generated charge carriers move through the BOX. Of the materials examined, the bond-and-etch-back silicon-on-insulator (BESOI) material containing a silicon nitride layer produced the lowest normalized photocurrents, heavy trapping of both carriers. By comparison BESOI with thermal oxide layers traps neither carrier in the oxide bulk. The results of this study should be considered in the design of radiation-hardened components and when considering processing variations. C1 ALLIEDSIGNAL AEROSP CO,COLUMBIA,MD 21045. RP PENNISE, CA (reprint author), USA,RES LAB,2800 POWDER MILL RD,ADELPHI,MD 20783, USA. NR 7 TC 8 Z9 9 U1 0 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9499 J9 IEEE T NUCL SCI JI IEEE Trans. Nucl. Sci. PD DEC PY 1993 VL 40 IS 6 BP 1765 EP 1773 DI 10.1109/23.273481 PN 1 PG 9 WC Engineering, Electrical & Electronic; Nuclear Science & Technology SC Engineering; Nuclear Science & Technology GA MV375 UT WOS:A1993MV37500068 ER PT J AU OLDHAM, TR BENNETT, KW BEAUCOUR, J CARRIERE, T POLVEY, C GARNIER, P AF OLDHAM, TR BENNETT, KW BEAUCOUR, J CARRIERE, T POLVEY, C GARNIER, P TI TOTAL-DOSE FAILURES IN ADVANCED ELECTRONICS FROM SINGLE IONS SO IEEE TRANSACTIONS ON NUCLEAR SCIENCE LA English DT Article ID 4-MB CMOS SRAM; HEAVY CHARGED-PARTICLES; LOAD STATIC RAM; ECL BICMOS SRAM; IN SELF-TEST; 64-MB DRAM; 16-MBIT DRAM; HOLE TRANSPORT; MOS CAPACITORS; LINE AB Hard errors from single heavy ions have been reported in advanced commercial CMOS memories. We examine the physical interactions of ions with MOS gate oxides-charge generation, recombination, transport and trapping. We also consider device and circuit characteristics. We conclude that hard errors from single ions are to be expected, and should not be considered surprising. C1 MATRA MARCONI SPACE, F-78146 VELIZY VILLACOUBLAY, FRANCE. RP USA, RES LAB, ADELPHI, MD 20783 USA. NR 77 TC 72 Z9 77 U1 0 U2 8 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 0018-9499 EI 1558-1578 J9 IEEE T NUCL SCI JI IEEE Trans. Nucl. Sci. PD DEC PY 1993 VL 40 IS 6 BP 1820 EP 1830 DI 10.1109/23.273474 PN 1 PG 11 WC Engineering, Electrical & Electronic; Nuclear Science & Technology SC Engineering; Nuclear Science & Technology GA MV375 UT WOS:A1993MV37500075 ER PT J AU MILETTA, JR CHASE, RJ LUU, BB WILLIAMS, JW VIVERITO, VJ AF MILETTA, JR CHASE, RJ LUU, BB WILLIAMS, JW VIVERITO, VJ TI MODELING OF ARMY RESEARCH LABORATORY EMP SIMULATORS SO IEEE TRANSACTIONS ON NUCLEAR SCIENCE LA English DT Article; Proceedings Paper CT IEEE 30th Annual International Nuclear and Space Radiation Effects Conference (NSREC) CY JUL 19-23, 1993 CL SNOWBIRD, UT SP IEEE, NUCL & PLASMA SCI SOC, RADIAT EFFECTS COMM, US DEPT DEF, DEF NUCL AGCY, US DEF ENERGY ENERGY, SANDIA NATL LAB, NASA, JET PROPULS LAB AB Models are required that permit the estimation of emitted field signatures from EMP simulators to design the simulator antenna structure, to establish the usable test volumes, and to estimate human exposure risk. This paper presents the capabilities and limitations of a variety of EMP simulator models useful to the Army's EMP survivability programs. Comparisons among frequency- and time-domain models are provided for two powerful U.S. Army Research Laboratory EMP simulators: AESOP (Army EMP Simulator Operations) and VEMPS II (Vertical EMP Simulator II). C1 SCI APPLICAT INT CORP,GERMANTOWN,MD 20874. RP MILETTA, JR (reprint author), USA,RES LAB,ADELPHI,MD 20783, USA. NR 8 TC 0 Z9 1 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9499 J9 IEEE T NUCL SCI JI IEEE Trans. Nucl. Sci. PD DEC PY 1993 VL 40 IS 6 BP 1967 EP 1976 DI 10.1109/23.273456 PN 1 PG 10 WC Engineering, Electrical & Electronic; Nuclear Science & Technology SC Engineering; Nuclear Science & Technology GA MV375 UT WOS:A1993MV37500093 ER PT J AU PERALA, RA RIGDEN, GJ PFEFFER, RA AF PERALA, RA RIGDEN, GJ PFEFFER, RA TI THE ARGUMENT FOR A UNIFIED APPROACH TO NONIONIZING RADIATION PROTECTION SO IEEE TRANSACTIONS ON NUCLEAR SCIENCE LA English DT Article; Proceedings Paper CT IEEE 30th Annual International Nuclear and Space Radiation Effects Conference (NSREC) CY JUL 19-23, 1993 CL SNOWBIRD, UT SP IEEE, NUCL & PLASMA SCI SOC, RADIAT EFFECTS COMM, US DEPT DEF, DEF NUCL AGCY, US DEF ENERGY ENERGY, SANDIA NATL LAB, NASA, JET PROPULS LAB AB In the next decade military equipment will be required to operate in severe electromagnetic environments. These environments are expected to contain most non-ionizing frequencies (D.C. to GHz), from hostile and/or non-hostile sources, and be severe enough to cause temporary upset or even catastrophic failure of electronic equipment. Over the past thirty years considerable emphasis has been placed on hardening critical systems to one or more of these non-ionizing radiation environments, the most prevalent being the nuclear-induced electromagnetic pulse (EMP). From this technology development there has evolved a hardening philosophy that applies to most of these non-ionizing radiation environments. The philosophy, which stresses the application of zonal shields plus penetration protection, can provide low-cost hardening against such diverse non-ionizing radiation as p-static, lightning, electromagnetic interference (EMI), EMP, high intensity radiated fields (HIRF), electromagnetic radiation (EMR), and high power microwaves (HPM). The objective in this paper is to describe the application of this philosophy to Army helicopters. We develop a unified specification complete with threat definitions and test methods which illustrates integration of EMP, lightning, and HIRF at the box qualification level. This paper is a summary of the effort documented in Reference [1]. C1 USA,NUCL & CHEM AGCY,SPRINGFIELD,VA 22150. RP PERALA, RA (reprint author), ELECTRO MAGNET APPLICAT INC,12567 W CEDAR DR,SUITE 250,LAKEWOOD,CO 80228, USA. NR 8 TC 0 Z9 0 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9499 J9 IEEE T NUCL SCI JI IEEE Trans. Nucl. Sci. PD DEC PY 1993 VL 40 IS 6 BP 1977 EP 1985 DI 10.1109/23.273455 PN 1 PG 9 WC Engineering, Electrical & Electronic; Nuclear Science & Technology SC Engineering; Nuclear Science & Technology GA MV375 UT WOS:A1993MV37500094 ER PT J AU WEIL, L PECHT, M HAKIM, E AF WEIL, L PECHT, M HAKIM, E TI RELIABILITY EVALUATION OF PLASTIC ENCAPSULATED PARTS SO IEEE TRANSACTIONS ON RELIABILITY LA English DT Article DE PLASTIC ENCAPSULATED MICROCIRCUIT; RELIABILITY COMPARISON AB This paper compares the failure rates of several families of plastic encapsulated microcircuits (PEMs) using both field & test data (test data are converted to device failure rates for field conditions using common acceleration equations) and Mil-Hdbk-217 calculations. Calculated failure rates are obtained from the Mil-Hdbk-217F for both plastic encapsulated and ceramic hermetic class-B microcircuits. Comparisons show that the results from Mil-Hdbk-217 are misleading and that the US military and Government part-selection methods should not be burdened by this -217 methodology. C1 UNIV MARYLAND,CALCE ELECTR PACKAGING RES CTR,COLLEGE PK,MD 20742. USA,RES LAB,AMSRL EP RA,FT MONMOUTH,NJ 07703. RP WEIL, L (reprint author), UTC,HAMILTON STANDARD,1 HAMILTON RD,WINDSOR LOCKS,CT 06096, USA. OI Pecht, Michael/0000-0003-1126-8662 NR 13 TC 8 Z9 8 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9529 J9 IEEE T RELIAB JI IEEE Trans. Reliab. PD DEC PY 1993 VL 42 IS 4 BP 536 EP 540 DI 10.1109/24.273571 PG 5 WC Computer Science, Hardware & Architecture; Computer Science, Software Engineering; Engineering, Electrical & Electronic SC Computer Science; Engineering GA NE255 UT WOS:A1993NE25500003 ER PT J AU CUSHING, MJ MORTIN, DE STADTERMAN, TJ MALHOTRA, A AF CUSHING, MJ MORTIN, DE STADTERMAN, TJ MALHOTRA, A TI COMPARISON OF ELECTRONICS-RELIABILITY ASSESSMENT APPROACHES SO IEEE TRANSACTIONS ON RELIABILITY LA English DT Article DE PHYSICS OF FAILURE; MIL-HDBK-217; RELIABILITY PREDICTION ID PREDICTION AB Two general approaches are available for assessing reliability of electronics during design: device failure-rate prediction, physics-of-failure. This article broadly compares these two approaches in a way that is readily understandable by the wide range of readers concerned with the design, manufacture, and support of electronic equipment. The most prominent device failure-rate prediction methodology, US Mil-Hdbk-217, does not provide the designer or manufacturer with any insight into, or control over, the actual causes of failure since the cause-and-effect relationships impacting reliability are not captured therein. Mil-Hdbk-217 does not address the design & usage parameters that strongly influence reliability; this problem results in an inability to tailor a Mil-Hdbk-217 prediction using these key parameters. Physics-of-failure methodology is an approach to design, reliability assessment, testing, screening, and stress margins that uses knowledge of root-cause failure mechanisms to prevent product failures through robust design & manufacturing practices. This approach proactively incorporates reliability into the design process by establishing a scientific basis for evaluating new materials, structures, and electronic technologies. This approach encourages innovative, cost-effective design through realistic reliability assessment. C1 UNIV MARYLAND,CALCE ELECTR PACKAGING RES CTR,COLLEGE PK,MD 20742. RP CUSHING, MJ (reprint author), USA,MAT SYST ANAL ACT,PHYS FAILURE OFF,ABERDEEN PROVING GROUND,MD 21005, USA. NR 17 TC 39 Z9 39 U1 0 U2 4 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9529 J9 IEEE T RELIAB JI IEEE Trans. Reliab. PD DEC PY 1993 VL 42 IS 4 BP 542 EP 546 DI 10.1109/24.273574 PG 5 WC Computer Science, Hardware & Architecture; Computer Science, Software Engineering; Engineering, Electrical & Electronic SC Computer Science; Engineering GA NE255 UT WOS:A1993NE25500006 ER PT J AU STILES, BG BAVARI, S KRAKAUER, T ULRICH, RG AF STILES, BG BAVARI, S KRAKAUER, T ULRICH, RG TI TOXICITY OF STAPHYLOCOCCAL ENTEROTOXINS POTENTIATED BY LIPOPOLYSACCHARIDE - MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-II MOLECULE DEPENDENCY AND CYTOKINE RELEASE SO INFECTION AND IMMUNITY LA English DT Article ID TUMOR-NECROSIS-FACTOR; T-CELLS; SHOCK SYNDROME; DEFICIENT MICE; INTERLEUKIN-1; ENDOTOXIN; SUPERANTIGEN AB The biological effects of staphylococcal enterotoxins (SE), potentiated by bacterial lipopolysaccharide (LPS), were studied with mice. Control animals survived the maximum dose of either SE or LPS, while mice receiving both agents died. SEA was 43-fold more potent than SEB and 20-fold more potent than SEC(1). The mechanism of toxicity was further examined with transgenic mice deficient in major histocompatibility complex class I or II expression. Class II-deficient mice were resistant to SEA or SEB. However, class I-deficient animals were less susceptible to SEA (30% lethality) than wild-type mice (93% lethality). In vitro stimulation of T cells from the three mouse phenotypes by SEA correlated well with toxicity. T cells from transgenic or wild-type mice were similarly responsive to SEA when presented by irradiated, wild-type mononuclear cells. These data confirmed that the toxicity of SE was mainly exerted through a mechanism dependent on the expression of major histocompatibility complex class II molecules. Toxicity was also linked to stimulated cytokine release. Levels in serum of tumor necrosis factor alpha, interleukin-6, and gamma interferon peaked 2 to 4 h after the potentiating dose of LPS but returned to normal within 10 h. Concentrations of interleukin-1 alpha were also maximal after 2 h but remained above the background for up to 22 h. Relative to the levels in mice given only SEA or LPS, the levels in serum of tumor necrosis factor alpha, interleukin-6, and gamma interferon increased 5-, 10-, and 15-fold, respectively, after injections of SEA plus LPS. There was only an additive effect of SEA and LPS on interleukin-1 alpha concentrations. C1 USA,MED RES INST INFECT DIS,DEPT CLIN IMMUNOL,FREDERICK,MD 21702. RP STILES, BG (reprint author), USA,MED RES INST INFECT DIS,DEPT IMMUNOL & MOLEC BIOL,FREDERICK,MD 21702, USA. NR 34 TC 113 Z9 120 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD DEC PY 1993 VL 61 IS 12 BP 5333 EP 5338 PG 6 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA MH823 UT WOS:A1993MH82300053 PM 8225606 ER PT J AU ZHUANG, HC SHAPIRO, M BAGLEY, CF AF ZHUANG, HC SHAPIRO, M BAGLEY, CF TI RELAXATION VEGETATION INDEX IN NONLINEAR MODELING OF GROUND PLANT COVER BY SATELLITE REMOTE-SENSING DATA SO INTERNATIONAL JOURNAL OF REMOTE SENSING LA English DT Article ID LANDSAT THEMATIC MAPPER; AVHRR DATA; NOAA AVHRR; WHEAT; SOIL; REFLECTANCES; RANGELANDS; RADIATION; SCALE; SMMR AB In order to obtain a model equation for the calculation of percentage plant cover by multi-spectral radiances remotely-sensed by satellites, a regression procedure is used to connect space remote-sensing data to ground plant cover measurement. A traditional linear regression model using the normalized difference vegetation index (NDVI) is examined by remote-sensing data of the SPOT satellite and ground measurement of LCTA project for a test site at Hohenfels, Germany. A relaxation vegetation index (RVI) is proposed in a non-linear regression modelling to replace the NDVI in linear regression modelling to get a better calculation of percentage plant cover. The definition of the RVI is RVI=[Sigma(i=1)alpha(i)X(i)+alpha(o)]/[Sigma(i=1)beta(i)X(i)+1], where X(i) is raw remote-sensing data in channel i. Using the RVI, the correlation coefficient between calculated and observed percentage plant cover for a test scene in 1989 reaches 0.9 while for the NDVI it is only 0.7; the coefficient of multiple determination R(2) reaches 0.8 for the RVI while it is only 0.5 for the NDVI. Numerical testing shows that the ability of using the RVI to predict percentage plant cover by space remote-sensing data for the same scene or the scene in other years is much stronger than the NDVI. RP ZHUANG, HC (reprint author), USA,CONSTRUCT ENGN RES LAB,DIV ENVIRONM,CHAMPAIGN,IL 61824, USA. NR 52 TC 6 Z9 6 U1 1 U2 1 PU TAYLOR & FRANCIS LTD PI LONDON PA ONE GUNDPOWDER SQUARE, LONDON, ENGLAND EC4A 3DE SN 0143-1161 J9 INT J REMOTE SENS JI Int. J. Remote Sens. PD DEC PY 1993 VL 14 IS 18 BP 3447 EP 3470 PG 24 WC Remote Sensing; Imaging Science & Photographic Technology SC Remote Sensing; Imaging Science & Photographic Technology GA MQ239 UT WOS:A1993MQ23900006 ER PT J AU GREEN, MG WALLACE, WA AF GREEN, MG WALLACE, WA TI LARGE-DIAMETER TUNNELING IN A SOFT CLAY SHALE - A CASE-HISTORY OF THE SAN-ANTONIO FLOOD-CONTROL TUNNELS SO INTERNATIONAL JOURNAL OF ROCK MECHANICS AND MINING SCIENCES & GEOMECHANICS ABSTRACTS LA English DT Article; Proceedings Paper CT 34th U.S. Symposium on Rock Mechanics CY JUN 27-30, 1993 CL UNIV WISCONSIN MADISON, MADISON, WI SP US NATL COMM ROCK MECH HO UNIV WISCONSIN MADISON AB Highly developed areas of San Antonio, Tx are protected from flooding by two tunnels that divert flood waters deep beneath the city. The San Antonio River Tunnel is approximately 4.97 km (3.1 mi) in length. The San Pedro Creek Tunnel is approximately 1.78 km (1.2 mi) in length. Both tunnels have 7.4 m (24 ft-4 in.) inside diameters with 30.5-an (12-in.) thick precast concrete segments. The tunnels were excavated by a shielded tunnel boring machine (TBM). Fallout above and in front of the TBM necessitated a change in the mining to a top heading through about 610 m (2000 ft) of blocky ground in the San Antonio River Tunnel. RP GREEN, MG (reprint author), USA CORPS ENGINEERS,FT WORTH DIST,POB 17300,FT WORTH,TX 76102, USA. NR 8 TC 1 Z9 1 U1 2 U2 4 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0148-9062 J9 INT J ROCK MECH MIN JI Int. J. Rock Mech. Min. Sci. PD DEC PY 1993 VL 30 IS 7 BP 1461 EP 1467 DI 10.1016/0148-9062(93)90138-4 PG 7 WC Engineering, Geological; Mining & Mineral Processing SC Engineering; Mining & Mineral Processing GA MR679 UT WOS:A1993MR67900137 ER PT J AU SIMMONS, MD AF SIMMONS, MD TI PERFORMANCE OF ROADHEADERS AT HARLAN, KY, DIVERSION TUNNELS SO INTERNATIONAL JOURNAL OF ROCK MECHANICS AND MINING SCIENCES & GEOMECHANICS ABSTRACTS LA English DT Article; Proceedings Paper CT 34th U.S. Symposium on Rock Mechanics CY JUN 27-30, 1993 CL UNIV WISCONSIN MADISON, MADISON, WI SP US NATL COMM ROCK MECH HO UNIV WISCONSIN MADISON AB Four side-by-side tunnels have recently been completed for the purpose of flood control for the town of Harlan, Kentucky. The inverted ''U'' shaped tunnels average 590 m (1935 ft) in length and are 9.75 m (32 ft) high by 10.4 m (34 ft) wide. They were constructed utilizing roadheaders through massive siltstone containing an average of 58 percent quartz and having an average unconfined compressive strength of 469 MPa (6800 psi). Two machines of different manufacture and size were used for the construction of the top heading and the performance of each has been documented A comparison to drill and blast is possible since the bottom heading was excavated in this manner. RP SIMMONS, MD (reprint author), USA CORPS ENGINEERS,NASHVILLE DIST,POB 1070,NASHVILLE,TN 37202, USA. NR 2 TC 0 Z9 0 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0148-9062 J9 INT J ROCK MECH MIN JI Int. J. Rock Mech. Min. Sci. PD DEC PY 1993 VL 30 IS 7 BP 1491 EP 1496 DI 10.1016/0148-9062(93)90143-2 PG 6 WC Engineering, Geological; Mining & Mineral Processing SC Engineering; Mining & Mineral Processing GA MR679 UT WOS:A1993MR67900142 ER PT J AU HYAMS, KC PHILLIPS, IA TEJADA, A WIGNALL, FS ROBERTS, CR ESCAMILLA, J AF HYAMS, KC PHILLIPS, IA TEJADA, A WIGNALL, FS ROBERTS, CR ESCAMILLA, J TI 3-YEAR INCIDENCE STUDY OF RETROVIRAL AND VIRAL-HEPATITIS TRANSMISSION IN A PERUVIAN PROSTITUTE POPULATION SO JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY LA English DT Article DE HIV-1; HTLV-I; HTLV-II; HEPATITIS-B; HEPATITIS-C; PROSTITUTION ID HUMAN-IMMUNODEFICIENCY-VIRUS; SEXUAL TRANSMISSION; HTLV-I; RISK-FACTORS; INFECTION; PREVALENCE; TYPE-1 AB A Peruvian female prostitute population was evaluated over a 3-year period to determine the incidence and risk factors of retroviral and viral hepatitis transmission. At three survey periods, a questionnaire was administered and serum samples were obtained. A total of 966 subjects were studied, with 34% followed for 38 months, 22% followed for 18 months, and 44% evaluated just once. On initial evaluation, 3 (0.3%) had HIV-1 antibody, 170 (17.6%) had HTLV-I antibody, 578 (59.8%) had anti-HBc, and 7 (0.7%) had antibody to hepatitis C virus. The mean annual incidence of HTLV-I and hepatitis B infection was 1.6% and 4.7%, respectively. Univariate and logistic regression analysis of prevalence data indicated an association between sexual activity and HTLV-I and hepatitis B infection, but no independent risk factors were identified in cohort analysis. Parenteral risk factors were not associated with transmission, except for a small percentage of subjects who may have acquired hepatitis B infection from blood transfusions. These findings suggest that there is a high incidence of HTLV-I and hepatitis B infection from heterosexual contact in this female prostitute population. C1 USN,MED RES INST,BETHESDA,MD 20814. NAVAL MED RES INST DETACHMENT,LIMA,PERU. SERV VENEREAS CALLAO,LIMA,PERU. UNIV NACL MAYOR SAN MARCOS,LIMA,PERU. NAVAL MED RES UNIT 2,JAKARTA,INDONESIA. WALTER REED ARMY INST RES,SILVER SPRING,MD. NR 20 TC 13 Z9 15 U1 0 U2 2 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 1077-9450 J9 J ACQ IMMUN DEF SYND JI J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. PD DEC PY 1993 VL 6 IS 12 BP 1353 EP 1357 PG 5 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA MM128 UT WOS:A1993MM12800012 PM 7504724 ER PT J AU MARDEN, LJ FAN, RSP PIERCE, GF REDDI, AH HOLLINGER, JO AF MARDEN, LJ FAN, RSP PIERCE, GF REDDI, AH HOLLINGER, JO TI PLATELET-DERIVED GROWTH-FACTOR INHIBITS BONE REGENERATION INDUCED BY OSTEOGENIN, A BONE MORPHOGENETIC PROTEIN, IN RAT CRANIOTOMY DEFECTS SO JOURNAL OF CLINICAL INVESTIGATION LA English DT Article DE WOUND REPAIR; CRITICAL-SIZE DEFECT; CALVARIA; DOSE DEPENDENT ID OSTEOBLAST-ENRICHED CULTURES; FACTOR-BETA; EXTRACELLULAR-MATRIX; TISSUE-REPAIR; FACTOR-BB; STIMULATION; INVIVO; CELLS; DIFFERENTIATION; SOMATOMEDIN AB Platelet-derived growth factor (PDGF) is a potent moderator of soft tissue repair through induction of the inflammatory phase of repair and subsequent enhanced collagen deposition. We examined the effect of recombinant BB homodimer PDGF (rPDGF-BB) applied to rat craniotomy defects, treated with and without bovine osteogenin (OG), to see if bone regeneration would be stimulated. Implants containing 0, 20, 60, or 200 mug rPDGF-BB, reconstituted with insoluble rat collagenous bone matrix containing 0, 30, or 150 mug OG, were placed into 8-mm craniotomies. After 11 d, 21 of the 144 rats presented subcutaneous masses superior to the defect sites. The masses, comprised of serosanguinous fluid encapsulated by fibrous connective tissue, were larger and occurred more frequently in rats treated with 200 mug rPDGF-BB, and were absent in rats not treated with rPDGF-BB. The masses underwent resorption within 28 d after surgery. OG (2-256 mug) caused a dose-dependent increase in radiopacity and a marked regeneration of calcified tissue in a dose-dependent fashion within defect sites. However, OG-induced bone regeneration was inhibited 17-53% in the presence of rPDGF-BB. These results suggest that rPDGF-BB inhibited OG-induced bone regeneration and stimulated a soft tissue repair wound phenotype and response. C1 WALTER REED ARMY MED CTR,INST DENT RES,DEPT PHYSIOL,WASHINGTON,DC 20307. AMGEN INC,DEPT EXPTL PATHOL,THOUSAND OAKS,CA 91320. JOHNS HOPKINS UNIV,SCH MED,BALTIMORE,MD 21205. NR 41 TC 71 Z9 71 U1 0 U2 4 PU ROCKEFELLER UNIV PRESS PI NEW YORK PA 1114 FIRST AVE, 4TH FL, NEW YORK, NY 10021 SN 0021-9738 J9 J CLIN INVEST JI J. Clin. Invest. PD DEC PY 1993 VL 92 IS 6 BP 2897 EP 2905 DI 10.1172/JCI116912 PG 9 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA ML643 UT WOS:A1993ML64300047 PM 8254045 ER PT J AU ECHEVERRIA, P JACKSON, LR HOGE, CW ARNESS, MK DUNNAVANT, GR LARSEN, RR AF ECHEVERRIA, P JACKSON, LR HOGE, CW ARNESS, MK DUNNAVANT, GR LARSEN, RR TI DIARRHEA IN UNITED-STATES TROOPS DEPLOYED TO THAILAND SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Note ID TRAVELERS DIARRHEA; ESCHERICHIA-COLI; PROPHYLAXIS; PERSONNEL; CELLS AB Ninety-five (28%) of 333 U.S. military personnel deployed to Ubonratchathani, Thailand, for 1 month in February 1993 developed diarrhea. Campylobacter jejuni was identified in 6 (25%), attaching and effacing Escherichia coli was identified in 3 (13%), nontyphoidal Salmonella spp. were identified in 2 (8%), and rotavirus was identified in 1 (4%) of 24 persons who had diarrhea and submitted specimens. C1 USAF,SPECIAL OPERAT GRP 353D,KADENA AIRBASE,JAPAN. NINETEENTH SPECIAL FORCES,SALT LAKE CITY,UT. RP ECHEVERRIA, P (reprint author), ARMED FORCES RES INST MED SCI,BANGKOK,THAILAND. NR 15 TC 18 Z9 18 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD DEC PY 1993 VL 31 IS 12 BP 3351 EP 3352 PG 2 WC Microbiology SC Microbiology GA MG725 UT WOS:A1993MG72500050 PM 8308137 ER PT J AU HONIG, PK WORTHAM, DC HULL, R ZAMANI, K SMITH, JE CANTILENA, LR AF HONIG, PK WORTHAM, DC HULL, R ZAMANI, K SMITH, JE CANTILENA, LR TI ITRACONAZOLE AFFECTS SINGLE-DOSE TERFENADINE PHARMACOKINETICS AND CARDIAC REPOLARIZATION PHARMACODYNAMICS SO JOURNAL OF CLINICAL PHARMACOLOGY LA English DT Article ID METABOLISM AB The object of this study was to examine prospectively the effects of itraconazole on the pharmacokinetics and electrocardiographic repolarization pharmacodynamics (QTc intervals) of single-dose terfenadine in six healthy volunteers. It was designed as a prospective cohort study with each subject serving as his own control, set in an outpatient cardiology clinic. The participants were six healthy volunteers (two men, four women; ages 24-35) not taking any prescription or over-the-counter medications. Single-dose terfenadine administration (120 mg) was accompanied by pharmacokinetic profiles and serial determination of the QTc interval for 12 hours. The subjects then began daily oral itraconazole (200 mg each morning) for 7 days. Repeat pharmacokinetic and pharmacodynamic determinations were made after administration of a second dose (120 mg) of terfenadine while receiving itraconazole. The main outcome measures were terfenadine and acid metabolite serum concentrations; corrected QT intervals os determined by 12-lead electrocardiogram (ECG); and presence or absence of late potentials as determined by signal-averaged ECGs over 150 cardiac cycles. There were significant changes in the pharmacokinetic parameters of acid metabolite after treatment with itraconazole. All subjects had detectable levels of unmetabolized terfenadine after addition of itraconazole, which was associated with QT prolongation. There was no evidence of late depolarization as manifested by an increase in QRS duration found using signal-averaged electrocardiography. Itraconazole influences the metabolism of terfenadine in normal volunteers and results in the accumulation of unmetabolized parent drug associated with altered cardiac repolarization. This drug combination should be avoided. C1 UNIFORMED SERV UNIV HLTH SCI,DEPT PHARMACOL,DIV CLIN PHARMACOL,BETHESDA,MD 20814. UNIFORMED SERV UNIV HLTH SCI,DEPT MED,DIV CLIN PHARMACOL,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,DIV CARDIOL,WASHINGTON,DC 20307. RI Zamani, Kaveh/A-9182-2011 FU FDA HHS [FDA 224-88-3006] NR 21 TC 81 Z9 81 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0091-2700 J9 J CLIN PHARMACOL JI J. Clin. Pharmacol. PD DEC PY 1993 VL 33 IS 12 BP 1201 EP 1206 PG 6 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA MP968 UT WOS:A1993MP96800009 PM 8126255 ER PT J AU WALTON, TL AF WALTON, TL TI OCEAN CITY, MARYLAND, WAVE RUNUP STUDY SO JOURNAL OF COASTAL RESEARCH LA English DT Article DE WAVE RUNUP; BEACHES; WAVE OVERTOPPING; WAVE SPECTRA; WAVE GROUPS ID NATURAL BEACH; SWASH AB An investigation of wave runup using video camera technology at Ocean City, Maryland, is discussed. Past studies on wave runup statistics are reviewed and practical problems of the ave runup prediction problem are noted. Results are provided from a subset of the runup experiment and differences between wave runup level probability density functions and wave runup amplitude probability density functions are detailed. RP WALTON, TL (reprint author), USA,ENGINEER WATERWAYS EXPT STN,COASTAL ENGN RES CTR,POB 631,VICKSBURG,MS 39180, USA. NR 25 TC 6 Z9 6 U1 0 U2 0 PU COASTAL EDUCATION & RESEARCH FOUNDATION PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 SN 0749-0208 J9 J COASTAL RES JI J. Coast. Res. PD WIN PY 1993 VL 9 IS 1 BP 1 EP 10 PG 10 WC Environmental Sciences; Geography, Physical; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Physical Geography; Geology GA KW242 UT WOS:A1993KW24200003 ER PT J AU GAFFNEY, DA AF GAFFNEY, DA TI DUNE SCARP EXHIBITS BIFURCATION SEQUENCE SO JOURNAL OF COASTAL RESEARCH LA English DT Note DE CHAOS THEORY; COASTAL DUNES; FRACTAL; GEOMORPHOLOGY AB A natural display of bifurcation is observed and related to deterministic chaos theory. A possible scenario is proposed from which an eroding dune scarp could be described. RP GAFFNEY, DA (reprint author), USA CORPS ENGINEERS,PHILADELPHIA DIST,100 PENN SQ E,WANAMAKER BLDG,PHILADELPHIA,PA 19107, USA. NR 5 TC 0 Z9 0 U1 0 U2 0 PU COASTAL EDUCATION & RESEARCH FOUNDATION PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 SN 0749-0208 J9 J COASTAL RES JI J. Coast. Res. PD WIN PY 1993 VL 9 IS 1 BP 279 EP 281 PG 3 WC Environmental Sciences; Geography, Physical; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Physical Geography; Geology GA KW242 UT WOS:A1993KW24200020 ER PT J AU OBRIEN, TK MARTIN, RH AF OBRIEN, TK MARTIN, RH TI ROUND-ROBIN TESTING FOR MODE-I INTERLAMINAR FRACTURE-TOUGHNESS OF COMPOSITE-MATERIALS SO JOURNAL OF COMPOSITES TECHNOLOGY & RESEARCH LA English DT Article DE COMPOSITE MATERIALS; DOUBLE CANTILEVER BEAM (DCB); INTERLAMINAR FRACTURE TOUGHNESS; DELAMINATION; STANDARD TEST METHOD AB This report summarizes the results of several interlaboratory ''round robin'' test programs for measuring the Mode I interlaminar fracture toughness of advanced fiber-reinforced composite materials. Double cantilever beam (DCB) tests were conducted by participants in ASTM Committee D-30 on High Modulus Fibers and Their Composites and by representatives of the European Group on Fracture (EGF) and the Japanese Industrial Standards Group (JIS). DCB tests were performed on three AS4 carbon fiber-reinforced composite materials: AS4/3501-6 with a brittle epoxy matrix. AS4/BP907 with a tough epoxy matrix, and AS4/PEEK with a tough thermoplastic matrix. Difficulties encountered in manufacturing panels, as well as conducting the tests, are discussed. Critical issues that developed during the course of the testing are highlighted. Results of the round robin testing used to determine the precision of the ASTM DCB test standard are summarized. C1 ANALYT SERV & MAT INC,HAMPTON,VA 23666. RP OBRIEN, TK (reprint author), NASA,USA RES LAB,LANGLEY RES CTR,VEHICLE STRUCT DIRECTORATE,HAMPTON,VA 23681, USA. NR 14 TC 56 Z9 56 U1 1 U2 4 PU AMER SOC TESTING MATERIALS PI W CONSHOHOCKEN PA 100 BARR HARBOR DR, W CONSHOHOCKEN, PA 19428-2959 SN 0884-6804 J9 J COMPOS TECH RES JI J. Compos. Technol. Res. PD WIN PY 1993 VL 15 IS 4 BP 269 EP 281 PG 13 WC Materials Science, Composites; Polymer Science SC Materials Science; Polymer Science GA MN396 UT WOS:A1993MN39600001 ER PT J AU JACKSON, WC POE, CC AF JACKSON, WC POE, CC TI THE USE OF IMPACT FORCE AS A SCALE PARAMETER FOR THE IMPACT RESPONSE OF COMPOSITE LAMINATES SO JOURNAL OF COMPOSITES TECHNOLOGY & RESEARCH LA English DT Article DE COMPOSITE MATERIAL; CARBON EPOXY; IMPACT; DELAMINATION; TRANSVERSE SHEAR FORCE AB The building block approach is currently used to design composite structures. With this approach, the data from coupon tests are scaled up to determine the design of a structure. Current standard impact tests and methods of relating test data to other structures are not generally understood and are often used improperly. A methodology is outlined for using impact force as a scale parameter for delamination damage for impacts of simple plates. Dynamic analyses were used to define ranges of plate parameters and impact parameters where quasi-static analyses are valid. These ranges include most low-velocity impacts where the mass of the impacter is large and the size of the specimen is small. For large-mass impacts of moderately thick (0.35 to 0.70 cm) laminates, the maximum extent of delamination damage increased with increasing impact force and decreasing specimen thickness. For large-mass impact tests at a given kinetic energy, impact force and hence delamination size depends on specimen size, specimen thickness, layup, boundary conditions, and indenter size and shape. If damage is reported in terms of impact force instead of kinetic energy, large-mass test results can be applied directly to other plates of the same thickness and layup. RP JACKSON, WC (reprint author), NASA,USA RES LAB,LANGLEY RES CTR,VEHICLE STRUCT DIRECTORATE,HAMPTON,VA 23681, USA. NR 17 TC 57 Z9 60 U1 0 U2 1 PU AMER SOC TESTING MATERIALS PI W CONSHOHOCKEN PA 100 BARR HARBOR DR, W CONSHOHOCKEN, PA 19428-2959 SN 0884-6804 J9 J COMPOS TECH RES JI J. Compos. Technol. Res. PD WIN PY 1993 VL 15 IS 4 BP 282 EP 289 PG 8 WC Materials Science, Composites; Polymer Science SC Materials Science; Polymer Science GA MN396 UT WOS:A1993MN39600002 ER PT J AU TOUSLEY, BC MEHTA, SM LOBAD, AI RODNEY, PJ FAUCHET, PM COOKE, P AF TOUSLEY, BC MEHTA, SM LOBAD, AI RODNEY, PJ FAUCHET, PM COOKE, P TI FEMTOSECOND OPTICAL-RESPONSE OF LOW-TEMPERATURE-GROWN IN0.53GA0.47AS SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article; Proceedings Paper CT Symposium on low temperature grown and higher nonstoichiometric GaAs and related materials, at the spring meeting of the Materials-Research-Society CY APR 12-13, 1993 CL SAN FRANCISCO, CA SP MAT RES SOC, USAF, OFF SCI RES DE CARRIER LIFETIME; LOW-TEMPERATURE-GROWN GAAS; MOLECULAR BEAM EPITAXY ID BEAM EPITAXIAL IN0.52AL0.48AS/INP; GALLIUM-ARSENIDE; CARRIERS AB A femtosecond, tunable color center laser was used to conduct degenerate pump-probe transmission spectroscopy of thin film low temperature grown molecular beam epitaxy In0.53Ga0.47As samples. Low temperature molecular beam epitaxy In0.53Ga0.47As exhibits a growth-temperature dependent femtosecond optical response when probed near the conduction band edge. Below T-g= 250 degrees C, the optical response time of the material is subpicosecond in duration, and we observe induced absorption, which we suggest is due to the formation of a quasi-''three-level system.'' C1 US MIL ACAD,DEPT ELECT ENGN & COMP SCI,W POINT,NY 10996. LAB LASER ENERGET,ROCHESTER,NY 14623. USA,RES LAB,FT MONMOUTH,NJ 07703. RP TOUSLEY, BC (reprint author), US MIL ACAD,US ARMY PHOTON RES CTR,W POINT,NY 10996, USA. NR 9 TC 11 Z9 11 U1 0 U2 1 PU MINERALS METALS MATERIALS SOC PI WARRENDALE PA 420 COMMONWEALTH DR, WARRENDALE, PA 15086 SN 0361-5235 J9 J ELECTRON MATER JI J. Electron. Mater. PD DEC PY 1993 VL 22 IS 12 BP 1477 EP 1480 DI 10.1007/BF02650002 PG 4 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA MK808 UT WOS:A1993MK80800024 ER PT J AU SCHOW, DA JACKSON, TL MORRISSEAU, PM TROTTER, SJ HOWE, DC JOHNSON, DL AF SCHOW, DA JACKSON, TL MORRISSEAU, PM TROTTER, SJ HOWE, DC JOHNSON, DL TI USE OF ALFENTANIL SEDATION ANESTHESIA WITH THE DORNIER HM3 LITHOTRIPTER SO JOURNAL OF ENDOUROLOGY LA English DT Article ID SHOCK-WAVE LITHOTRIPSY; PIEZOELECTRIC EXTRACORPOREAL LITHOTRIPSY; EXPERIENCE AB Our results with the combination anesthetic technique of midazolam-alfentanil during elective outpatient extracorporeal shock wave lithotripsy on the Dornier HM3 (N = 79) were compared with those of epidural anesthesia in the same setting (N = 81). The mean anesthesia time and recovery room time were significantly shorter (72.85 v 113.58 minutes and 115.0 v 159.20 minutes, respectively) with the combination technique. No procedures in the alfentanil group had to be discontinued because of patient discomfort. Side effects with alfentanil were minimal, and oxygen saturation remained above 90% for all patients. Combination midazolam-alfentanil anesthesia is safe and allows the urologist to treat renal and ureteral calculi effectively and efficiently wihout using general or regional anesthesia. C1 MED CTR HOSP VERMONT,DEPT UROL,BURLINGTON,VT. MED CTR HOSP VERMONT,DEPT ANESTHESIOL,BURLINGTON,VT. RP SCHOW, DA (reprint author), BROOKE ARMY MED CTR,UROL SERV,SAN ANTONIO,TX 78234, USA. NR 18 TC 7 Z9 7 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0892-7790 J9 J ENDOUROL JI J. Endourol. PD DEC PY 1993 VL 7 IS 6 BP 445 EP 448 DI 10.1089/end.1993.7.445 PG 4 WC Urology & Nephrology SC Urology & Nephrology GA MQ382 UT WOS:A1993MQ38200002 PM 8124333 ER PT J AU LETTERIE, GS HIBBERT, ML MORGENSTERN, LL AF LETTERIE, GS HIBBERT, ML MORGENSTERN, LL TI A PROGRAM OF INSTRUCTION IN OPERATIVE LAPAROSCOPY IN A RESIDENCY IN OBSTETRICS AND GYNECOLOGY SO JOURNAL OF GYNECOLOGIC SURGERY LA English DT Article AB Operative laparoscopy has found an increasingly innovative role.in contemporary gynecologic practice. Residency programs must now formulate protocols for training in laparoscopic surgery on which subsequent credentialling may be safely recommended. This report describes a program of instruction in operative laparoscopy and the number of procedures required to develop technical skills at each year level of a 4-year residency. The objective of the program was to develop clinical judgment and technical skills in operative laparoscopy during the first 3 resident years. The main outcome measurement was the safe performance of complicated operative laparoscopy during the fourth resident year. This progam emphasized progressive, graded responsibility in operative laparoscopy to develop skills in both the principles and practice of laparoscopic surgery. Principles were taught through didactic sessions in laparoscopic instruments and techniques, assignment of reading lists for each year level, and a review of videotapes to assist in decision making for each procedure. Skills in technique and development of manual dexterity were taught over 4 years as follows. Postgraduate year (PGY) 1: restricted to diagnostic procedures emphasizing the development of basic eye-hand coordination using a video monitor system; PGY2: incorporation of principles of laparoscopic hemostasis and laparoscopic tubal ligation; PGY3: operative laparoscopy using multiple puncture sites, sharp dissection, and suture techniques; PGY4: progressively more complicated procedures to include salpingectomy, salpingostomy, and segmental resection for ectopic pregnancies; oophorectomy for benign disease, appendectomy, and adhesiolysis. Using this protocol of instruction, our senior residents performed a total of 65 operative laparoscopies as primary surgeon, accounting for 10% of their major gynecologic surgery. Sixty percent of ectopic pregnancies were managed laparoscopically. The number of procedures for the preceeding 3 years in training included 25.6 +/- 2.1, 48.0 +/- 2.5, and 37.3 +/- 3.1 (mean +/- standard deviation) for postgraduate years 1, 2, and 3, respectively. Equally important, documentation of a case list of operative laparoscopy for 4 years of training was generated for credentialling purposes. C1 TRIPLER ARMY MED CTR,DEPT OBSTET & GYNECOL,HONOLULU,HI 96859. NR 5 TC 3 Z9 3 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 1042-4067 J9 J GYNECOL SURG JI J. Gynecol. Surg. PD WIN PY 1993 VL 9 IS 4 BP 187 EP 190 DI 10.1089/gyn.1993.9.187 PG 4 WC Obstetrics & Gynecology; Surgery SC Obstetrics & Gynecology; Surgery GA MR270 UT WOS:A1993MR27000001 PM 10172014 ER PT J AU BODHIDATTA, L HOGE, CW CHURNRATANAKUL, S NIRDNOY, W SAMPATHANUKUL, P TUNGTAEM, C RAKTHAM, S SMITH, CD ECHEVERRIA, P AF BODHIDATTA, L HOGE, CW CHURNRATANAKUL, S NIRDNOY, W SAMPATHANUKUL, P TUNGTAEM, C RAKTHAM, S SMITH, CD ECHEVERRIA, P TI DIAGNOSIS OF HELICOBACTER-PYLORI INFECTION IN A DEVELOPING-COUNTRY - COMPARISON OF 2 ELISAS AND A SEROPREVALENCE STUDY SO JOURNAL OF INFECTIOUS DISEASES LA English DT Note ID ANTIBODIES; GASTRITIS AB Serology to detect antibodies to Helicobacter pylori is not frequently used as a diagnostic tool in developing countries. When compared to a commercial ELISA, an ELISA constructed and validated in Thailand had a higher sensitivity (98% vs. 85%), specificity (76% vs. 66%), and negative predictive value (97% vs. 76%) for the detection of H. pylori infection among 104 patients with dyspepsia evaluated by endoscopy. The positive predictive value was 88% for both tests. Serum antibody levels fell significantly 5-8 months after eradication of infection in 8 Thai patients (P = .009). By 8 years of age, >50% of Thai persons living in urban and rural locations were seropositive. The low negative predictive value of the commercial ELISA limits the usefulness of this assay as a diagnostic tool in Thailand and suggests a need to reevaluate H. pylori serologic tests when used in populations living in developing countries. C1 ARMED FORCES RES INST MED SCI,DEPT BACTERIOL,BANGKOK,THAILAND. PRAMONGKUTKLAO HOSP,DEPT GASTROENTEROL,BANGKOK,THAILAND. ARMED FORCES RES INST MED SCI,DEPT IMMUNOL,BANGKOK,THAILAND. ARMED FORCES RES INST MED SCI,DEPT MOLEC GENET,BANGKOK,THAILAND. ARMED FORCES RES INST MED SCI,DEPT VET MED,BANGKOK,THAILAND. CHULALONGKORN HOSP,DEPT PATHOL,BANGKOK,THAILAND. DINDAENG HLTH CLIN,BANGKOK,THAILAND. SUAN PHUNG HOSP,SUAN PHUNG,THAILAND. NR 15 TC 61 Z9 65 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD DEC PY 1993 VL 168 IS 6 BP 1549 EP 1553 PG 5 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA MJ709 UT WOS:A1993MJ70900035 PM 8245544 ER PT J AU WASSERMAN, L DOCTOR, BP GENTRY, MK TAYLOR, P AF WASSERMAN, L DOCTOR, BP GENTRY, MK TAYLOR, P TI EPITOPE MAPPING OF FORM-SPECIFIC AND NONSPECIFIC ANTIBODIES TO ACETYLCHOLINESTERASE SO JOURNAL OF NEUROCHEMISTRY LA English DT Article DE ACETYLCHOLINESTERASE; EPITOPE MAPPING; MONOCLONAL ANTIBODIES ID TORPEDO ELECTRIC ORGAN; ASYMMETRIC ACETYLCHOLINESTERASE; MONOCLONAL-ANTIBODIES; DIMERIC FORM; CHOLINESTERASES; LOCALIZATION; EXPRESSION; HNK-1 AB We have mapped the epitopes to which two monoclonal antibodies against acetylcholinesterase (AChE) from Torpedo caifornica are directed. One antibody, 2C9, has equivalent affinity for both the 5.6S (amphiphilic) and 11S (hydrophilic) enzyme forms; the other, 4E7, recognizes only the amphiphilic form and has been shown previously to require an N-linked oligosaccharide residue on the protein. Isolation of cyanogen bromide peptides from the amphiphilic form and assay by a competition ELISA for 2C9 and by a direct binding ELISA for 4E7 identified the same peptide, residues 44-82, as containing epitopes against both antibodies. The epitope for 4E7 includes the oligosaccharide conjugated to Asp59, an N-linked glycosylation site not present in mouse AChE. A 20-amino-acid synthetic peptide, RFRRPEPKKPWSGVWNASTY, representing residues 44-63, was synthesized and found to inhibit completely 2C9 binding to 5.6S enzyme at molar concentrations comparable to those of the cyanogen bromide peptide. It was unreactive with 4E7. Fractionation of the synthetic peptide further localized the 2C9 epitope. Peptides RFRRPEPKKPW and KPWSGVWNASTY both reacted but less so than the entire synthetic peptide at equivalent molar concentrations, whereas the peptide RPEPKKPWSGVWNASTY was as effective as the larger synthetic peptide. The crystal structure of AChE shows the peptide to be on the surface of the molecule as part of a convex hairpin loop starting before the first alpha-helix. C1 UNIV CALIF SAN DIEGO,DEPT PHARMACOL,BASIC SCI BLDG 0636,LA JOLLA,CA 92093. WALTER REED ARMY INST RES,DIV BIOCHEM,WASHINGTON,DC 20307. FU NIGMS NIH HHS [GM18360] NR 26 TC 4 Z9 4 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0022-3042 J9 J NEUROCHEM JI J. Neurochem. PD DEC PY 1993 VL 61 IS 6 BP 2124 EP 2132 DI 10.1111/j.1471-4159.1993.tb07450.x PG 9 WC Biochemistry & Molecular Biology; Neurosciences SC Biochemistry & Molecular Biology; Neurosciences & Neurology GA MH022 UT WOS:A1993MH02200017 PM 7504082 ER PT J AU MAPOU, RL LAW, WA MARTIN, A KAMPEN, D SALAZAR, AM RUNDELL, JR AF MAPOU, RL LAW, WA MARTIN, A KAMPEN, D SALAZAR, AM RUNDELL, JR TI NEUROPSYCHOLOGICAL PERFORMANCE, MOOD, AND COMPLAINTS OF COGNITIVE AND MOTOR DIFFICULTIES IN INDIVIDUALS INFECTED WITH THE HUMAN-IMMUNODEFICIENCY-VIRUS SO JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES LA English DT Article ID HOMOSEXUAL MEN; AIDS AB Seventy-nine military medical beneficiaries infected with human immunodeficiency virus (HIV+) and 27 HIV-seronegative control subjects (HIV-) completed a neuropsychological evaluation and a semistructured interview inquiring about difficulties in function. More HIV+ than HIV- subjects reported difficulties. HIV+ subjects reporting difficulties were significantly more likely to be deficient on attention, response speed, motor function, and memory than those not reporting difficulties. Findings for early-stage HIV+ subjects were similar. HIV+ individuals who complained of difficulties reported depression and anxiety symptoms significantly more frequently than those who did not complain, but these symptoms were not related to neuropsychological performance. Complaints of difficulties by HIV+ individuals may reflect either actual neuropsychological deficiency or mood disturbance, but the effects of each appear to be independent. C1 NIMH,BETHESDA,MD 20892. UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. WALTER REED ARMY INST RES,WASHINGTON,DC 20307. RP MAPOU, RL (reprint author), HENRY M JACKSON FDN ADVANCEMENT MIL MED,MIL MED CONSORTIUM APPL RETROVIRAL RES,1 TAFT COURT,ROCKVILLE,MD 20850, USA. RI martin, alex/B-6176-2009 NR 35 TC 50 Z9 50 U1 0 U2 0 PU AMER PSYCHIATRIC ASSOCIATION PI WASHINGTON PA 1400 K ST NW, WASHINGTON, DC 20005 SN 0895-0172 J9 J NEUROPSYCH CLIN N JI J. Neuropsychiatr. Clin. Neurosci. PD WIN PY 1993 VL 5 IS 1 BP 86 EP 93 PG 8 WC Clinical Neurology; Neurosciences; Psychiatry SC Neurosciences & Neurology; Psychiatry GA KK041 UT WOS:A1993KK04100014 PM 8428141 ER PT J AU PATTERSON, AL GALLOWAY, RH BAUMGARTNER, JC BARSOUM, IS AF PATTERSON, AL GALLOWAY, RH BAUMGARTNER, JC BARSOUM, IS TI DEVELOPMENT OF CHRONIC MANDIBULAR OSTEOMYELITIS IN A MINISWINE MODEL SO JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY LA English DT Article ID STAPHYLOCOCCUS-AUREUS OSTEOMYELITIS; MINIATURE SWINE C1 WALTER REED ARMY MED CTR,USA INST DENT RES,DENT CORPS,WASHINGTON,DC 20307. OREGON HLTH SCI UNIV,SCH DENT,DEPT ENDODONTOL,PORTLAND,OR 97201. WALTER REED ARMY MED CTR,USA INST DENT RES,MICROBIOL BRANCH,WASHINGTON,DC 20307. NR 14 TC 8 Z9 8 U1 0 U2 3 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0278-2391 J9 J ORAL MAXIL SURG JI J. Oral Maxillofac. Surg. PD DEC PY 1993 VL 51 IS 12 BP 1358 EP 1362 PG 5 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA MK563 UT WOS:A1993MK56300013 PM 8229416 ER PT J AU BRYAN, JM GEROY, GD ISERNHAGEN, SJ AF BRYAN, JM GEROY, GD ISERNHAGEN, SJ TI NONCLINICAL COMPETENCES FOR PHYSICAL-THERAPISTS CONSULTING WITH BUSINESS AND INDUSTRY SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Article DE COMPETENCES; INDUSTRIAL PHYSICAL THERAPY AB Industrial physical therapists (IPTs) are working as external consultants with business and industry to provide injury prevention and/or rehabilitation services. This consulting presents a very new practice setting for therapists and requires specialized nonclinical competencies. The purpose of this study was to identify these nonclinical competencies. The research was based on an evaluation research model using a stakeholder group. Stakeholders represented five groups: 1) IPTs, 2) continuing education providers, 3) business and industry employers of IPTs, 4) safety/risk managers, and 5) human resource development professionals. Thirty-five nonclinical competencies were identified through qualitative analysis of in-depth interviews with 17 subject matter experts representing the five groups. The competencies addressed marketing, program planning, managing the consulting process, training, and understanding organizations. This list of nonclinical competencies may serve as a self-assessment tool that IPTs can use to help plan their professional development. It may also facilitate planning continuing education programs for IPTs. RP BRYAN, JM (reprint author), BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234, USA. NR 0 TC 1 Z9 1 U1 0 U2 3 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0190-6011 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD DEC PY 1993 VL 18 IS 6 BP 673 EP 681 PG 9 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA MK117 UT WOS:A1993MK11700006 PM 8281181 ER PT J AU BEEBE, MM SMITH, MD AF BEEBE, MM SMITH, MD TI OMENTAL LIPOBLASTOMA SO JOURNAL OF PEDIATRIC SURGERY LA English DT Note DE LIPOBLASTOMA; OMENTAL TUMOR ID CHILDREN C1 CHILDRENS HOSP,SANTA ROSA HLTH CARE CORP,SAN ANTONIO,TX. RP BEEBE, MM (reprint author), BROOKE ARMY MED CTR,DEPT SURG,GEN SURG SERV,FT SAM HOUSTON,TX 78234, USA. NR 10 TC 23 Z9 26 U1 0 U2 1 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0022-3468 J9 J PEDIATR SURG JI J. Pediatr. Surg. PD DEC PY 1993 VL 28 IS 12 BP 1626 EP 1627 DI 10.1016/0022-3468(93)90122-2 PG 2 WC Pediatrics; Surgery SC Pediatrics; Surgery GA ML662 UT WOS:A1993ML66200037 PM 8301515 ER PT J AU LEEK, MR SUMMERS, V AF LEEK, MR SUMMERS, V TI AUDITORY FILTER SHAPES OF NORMAL-HEARING AND HEARING-IMPAIRED LISTENERS IN CONTINUOUS BROAD-BAND NOISE SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Article ID FREQUENCY-SELECTIVITY; CONSONANT RECOGNITION; TUNING CURVES; ASYMMETRY; LEVEL; THRESHOLD; MASKING AB Listeners with sensorineural hearing impairment typically exhibit auditory processing deficits such as reduced frequency and/or temporal resolution. Such deficits may represent separate sequela of auditory pathology or may result directly from the sensitivity loss and the requirement to listen at high levels. To assess the impact of increased thresholds on frequency resolution, auditory filter characteristics were determined for hearing-impaired and normal-hearing listeners at 500 and 2000 Hz in the presence of continuous broadband noise meant as a rough simulation of hearing loss. In the fitting procedure, the low-frequency skirt of the derived auditory filter was allowed to vary as a function of signal level, permitting different filter shapes to be estimated at high versus low signal levels. Listeners with moderate hearing losses at 2000 Hz demonstrated near-normal auditory filter shapes for lower signal levels, but increasingly broad and asymmetric filters as signal level was raised. At 500 Hz, where hearing losses were mild, filter bandwidths increased little at the higher signal levels. The presence of broadband noise had essentially no effect on filter shapes of either listener group. The filter shape abnormalities demonstrated by listeners with moderate hearing loss, which were not observed in normal-hearing listeners at the same signal levels, indicate that poor frequency resolution in these patients for high-intensity stimuli does not follow directly from decreased sensitivity, but instead reflects an independent pathology. RP LEEK, MR (reprint author), WALTER REED ARMY MED CTR,CTR AUDIOL & SPEECH,WASHINGTON,DC 20307, USA. FU NIDCD NIH HHS [DC 00626] NR 22 TC 49 Z9 49 U1 0 U2 1 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0001-4966 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD DEC PY 1993 VL 94 IS 6 BP 3127 EP 3137 DI 10.1121/1.407218 PG 11 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA MM126 UT WOS:A1993MM12600010 PM 8300951 ER PT J AU KECSKES, LJ NIILER, A KOTTKE, T AF KECSKES, LJ NIILER, A KOTTKE, T TI PRECURSOR MORPHOLOGY EFFECTS IN COMBUSTION-SYNTHESIZED AND DYNAMICALLY CONSOLIDATED TITANIUM CARBIDE AND TITANIUM BORIDE SO JOURNAL OF THE AMERICAN CERAMIC SOCIETY LA English DT Article AB The combustion synthesis/dynamic consolidation (CS/DC) technique was applied to titanium-carbon and titanium-boron mixtures with different initial precursor carbon and boron powder morphologies. The evolution of the CS/DC product structure was investigated by analyzing and comparing the combustion synthesis products following three fabrication process steps: reacted loose powders, reacted green compacts, and reacted green compacts which were dynamically consolidated shortly after the synthesis. In all cases, the purity of the precursor carbon and boron powders was found to affect the residual porosity of the products. However, the dependence of the resultant product grain morphology on the morphology of the precursors was not as straightforward. Correlations between the respective product structures and possible reaction mechanisms are discussed. RP KECSKES, LJ (reprint author), USA,RES LAB,ABERDEEN PROVING GROUND,MD 21005, USA. RI Kecskes, Laszlo/F-6880-2014 OI Kecskes, Laszlo/0000-0002-1342-3729 NR 9 TC 8 Z9 8 U1 0 U2 2 PU AMER CERAMIC SOC PI WESTERVILLE PA 735 CERAMIC PLACE, PO BOX 6136, WESTERVILLE, OH 43081-6136 SN 0002-7820 J9 J AM CERAM SOC JI J. Am. Ceram. Soc. PD DEC PY 1993 VL 76 IS 12 BP 2961 EP 2970 DI 10.1111/j.1151-2916.1993.tb06596.x PG 10 WC Materials Science, Ceramics SC Materials Science GA MM410 UT WOS:A1993MM41000003 ER PT J AU MANGUIN, S PEYTON, EL JAMES, AC ROBERTS, DR AF MANGUIN, S PEYTON, EL JAMES, AC ROBERTS, DR TI APPARENT CHANGES IN THE ABUNDANCE AND DISTRIBUTION OF ANOPHELES SPECIES ON GRENADA SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Article AB Results of a recent survey of the 3 species of Anopheles mosquitoes, Anopheles (Nyssorhynchus) aquasalis, Anopheles (Nyssorhynchus) argyritarsis, and Anopheles (Anopheles) pseudopunctipennis, on the island of Grenada are contrasted with the only other published survey of these species on Grenada, which was published in 1938. Results suggest that a significant change in the abundance and distribution of each species has occurred over this period. Physical characteristics of the aquatic habitats for each species are described and compared. C1 WALTER REED ARMY INST RES,DEPT EMTOMOL,WALTER REED BIOSYSTEMAT UNIT,WASHINGTON,DC 20307. MINIST HLTH,GRENADA,W IND ASSOC ST. RP MANGUIN, S (reprint author), USUHS,DEPT PREVENT MED & BIOMETR,4301 JONES BRIDGE RD,BETHESDA,MD 20814, USA. RI Manguin, Sylvie/G-1787-2015 OI Manguin, Sylvie/0000-0002-5925-7164 NR 12 TC 12 Z9 12 U1 0 U2 2 PU AMER MOSQUITO CONTROL ASSN INC PI LAKE CHARLES PA 707-A EAST PRIEN LAKE ROAD, PO BOX 5416, LAKE CHARLES, LA 70606-5416 SN 8756-971X J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD DEC PY 1993 VL 9 IS 4 BP 403 EP 407 PG 5 WC Entomology SC Entomology GA MV752 UT WOS:A1993MV75200005 PM 8126473 ER PT J AU FRANCES, SP EIKARAT, N SRIPONGSAI, B EAMSILA, C AF FRANCES, SP EIKARAT, N SRIPONGSAI, B EAMSILA, C TI RESPONSE OF ANOPHELES-DIRUS AND AEDES-ALBOPICTUS TO REPELLENTS IN THE LABORATORY SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Note AB Laboratory tests were conducted to study the response of Anopheles dirus and Aedes albopictus to repellent formulations containing diethyl methylbenzamide (deet) and dimethyl phthalate. Anopheles dirus was tolerant of low concentrations of deet (5-20%), and formulations containing less than or equal to 35% deet provided protection for less than or equal to 90 min. In contrast, Ae. albopictus was sensitive to these formulations, which provided greater than or equal to 180 min protection from bites. C1 ARMED FORCES RES INST MED SCI,THAI MED COMPONENT,DIV RES,BANGKOK 10400,THAILAND. RP FRANCES, SP (reprint author), ARMED FORCES RES INST MED SCI,ARMY MED COMPONENT,DEPT ENTOMOL,315-6 RAJVITHI RD,BANGKOK 10400,THAILAND. NR 9 TC 40 Z9 43 U1 0 U2 0 PU AMER MOSQUITO CONTROL ASSN INC PI LAKE CHARLES PA 707-A EAST PRIEN LAKE ROAD, PO BOX 5416, LAKE CHARLES, LA 70606-5416 SN 8756-971X J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD DEC PY 1993 VL 9 IS 4 BP 474 EP 476 PG 3 WC Entomology SC Entomology GA MV752 UT WOS:A1993MV75200021 PM 8126487 ER PT J AU WALKER, CW SALOMON, M AF WALKER, CW SALOMON, M TI IMPROVEMENT OF IONIC-CONDUCTIVITY IN PLASTICIZED PEO-BASED SOLID POLYMER ELECTROLYTES SO JOURNAL OF THE ELECTROCHEMICAL SOCIETY LA English DT Article ID POLYVINYL-CHLORIDE) PROPERTIES; VALINOMYCIN ELECTRODES; FREQUENCY AB The ionic conductivity of a solid polymer electrolyte based on a lithium salt dissolved in a poly(ethylene oxide) (PEO) host was significantly improved with the use of plasticizing agents. Either a plasticizing salt, solvent, or combinations of both were incorporated into free-standing solution-cast films of (PEO)(x)(LiCF3SO3). The greatest enhancement of conductivity was observed when a plasticizing salt (LiN[CF3SO2](2)) and solvent (diethyl phthalate) were combined, with the most notable improvement occurring below the melting temperature of PEO (approximate to 66 degrees C). Conductivity increased from 7.7 X 10(-7) S cm(-1) at 20 degrees C to 4.6 x 10(-5) S cm(-1) with the addition of both plasticizers. RP WALKER, CW (reprint author), USA,RES LAB,AMSRL EP PB,ELECTR & POWER SOURCES DIRECTORATE,FT MONMOUTH,NJ 07703, USA. NR 21 TC 76 Z9 77 U1 0 U2 7 PU ELECTROCHEMICAL SOC INC PI PENNINGTON PA 10 SOUTH MAIN STREET, PENNINGTON, NJ 08534 SN 0013-4651 J9 J ELECTROCHEM SOC JI J. Electrochem. Soc. PD DEC PY 1993 VL 140 IS 12 BP 3409 EP 3412 DI 10.1149/1.2221103 PG 4 WC Electrochemistry; Materials Science, Coatings & Films SC Electrochemistry; Materials Science GA MQ350 UT WOS:A1993MQ35000018 ER PT J AU BINDER, M MAMMONE, RJ THURSTON, EP REDDY, TB AF BINDER, M MAMMONE, RJ THURSTON, EP REDDY, TB TI GAS PLASMA TREATMENT OF CATHODES TO IMPROVE LI/SO2 CELL PERFORMANCE SO JOURNAL OF THE ELECTROCHEMICAL SOCIETY LA English DT Letter AB Overall performance after storage at 71 degrees C of spirally wound, hermetically sealed, Li/SO2 squat ''D'' sized cells discharged at 3 A at -29 degrees C can be improved by exposing the porous carbon cathodes to a room temperature, low pressure gas plasma prior to cell assembly. C1 POWER CONVERS INC,ELMWOOD PK,NJ 07407. RP BINDER, M (reprint author), USA,ELECTR & POWER SOURCES DIRECTORATE,ENERGY SCI BRANCH,AMSRL EP PB,FT MONMOUTH,NJ 07703, USA. NR 5 TC 0 Z9 0 U1 1 U2 1 PU ELECTROCHEMICAL SOC INC PI PENNINGTON PA 10 SOUTH MAIN STREET, PENNINGTON, NJ 08534 SN 0013-4651 J9 J ELECTROCHEM SOC JI J. Electrochem. Soc. PD DEC PY 1993 VL 140 IS 12 BP L167 EP L168 DI 10.1149/1.2221152 PG 2 WC Electrochemistry; Materials Science, Coatings & Films SC Electrochemistry; Materials Science GA MQ350 UT WOS:A1993MQ35000001 ER PT J AU KRUEGER, GP AF KRUEGER, GP TI ENVIRONMENTAL MEDICINE RESEARCH TO SUSTAIN HEALTH AND PERFORMANCE DURING MILITARY DEPLOYMENT - DESERT, ARCTIC, HIGH-ALTITUDE STRESSORS SO JOURNAL OF THERMAL BIOLOGY LA English DT Article; Proceedings Paper CT International Conference on Human-Environment System CY DEC, 1991 CL TOKYO, JAPAN DE MILITARY DEPLOYMENT; SOLDIER STRESSORS; PREVENTIVE MEASURES FOR ENVIRONMENTAL EXTREMES AB 1. Rapid deployment of military forces to extreme naturally harsh environments presents combatants with physiological, biological and psychological stresses that: (1) affect mood, motivation, activation; (2) result in decreased job performance; (3) make accidents more likely; (4) lead to illnesses and non-battle injuries; and (5) jeopardize mission success. 2. Laboratory and field research help develop countermeasures to assist military forces in adjusting to hot dry desert, hot wet jungle, cold arctic regions, and high terrestrial altitudes. 3. Proven preventive medicine techniques and advanced concepts for deployment preparation include: pre-acclimatization, anti-jet lag measures, hydration, selection of rations based on nutrition requirements, pharmacological intervention, field sanitation, work-rest-sleep scheduling, and controlling operational stresses. RP KRUEGER, GP (reprint author), USA,ENVIRONM MED RES INST,NATICK,MA 01760, USA. NR 10 TC 1 Z9 1 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0306-4565 J9 J THERM BIOL JI J. Therm. Biol. PD DEC PY 1993 VL 18 IS 5-6 BP 687 EP 690 DI 10.1016/0306-4565(93)90114-9 PG 4 WC Biology; Zoology SC Life Sciences & Biomedicine - Other Topics; Zoology GA MT807 UT WOS:A1993MT80700069 ER PT J AU GUO, ZM QIAN, CG PETERS, CJ LIU, CT AF GUO, ZM QIAN, CG PETERS, CJ LIU, CT TI CHANGES IN PLATELET-ACTIVATING-FACTOR, CATECHOLAMINE, AND SEROTONIN CONCENTRATIONS IN BRAIN, CEREBROSPINAL-FLUID, AND PLASMA OF PICHINDE VIRUS-INFECTED GUINEA-PIGS SO LABORATORY ANIMAL SCIENCE LA English DT Article ID NEUROGENIC PULMONARY-EDEMA; FACTOR PAF; RAT-BRAIN; MEDIAN-EMINENCE; INVOLVEMENT; MECHANISMS; DOPAMINE; HORMONE; STRESS AB Brain concentrations of platelet-activating factor (PAF), catecholamines, and serotonin were measured in control and Pichinde virus-infected strain 13 guinea pigs on postinoculation day (PID) 12. After virus inoculation, PAF concentrations increased 81% in cerebrum, 147% in diencephalon-brain stem, and 110% in cerebellum from baseline values of 2.6 +/- 0.3, 4.3 +/- 0.2, and 6.1 +/- 0.5 (ng/g wet tissue), respectively. Dopamine concentrations in the infected cerebrum and diencephalon-brain stem increased significantly, whereas norepinephrine concentration increased only in cerebrum. However, serotonin concentrations in all three regions of infected brain decreased significantly as compared with control values. There were no significant changes in epinephrine concentrations of infected brain. Norepinephrine and epinephrine concentrations in plasma and cerebrospinal fluid on PID 7 and 12 increased significantly as compared with control values, while plasma dopamine concentration increased significantly on PID 7. Increased brain PAF, dopamine, and norepinephrine concentrations with decreased brain serotonin concentrations may mediate the hyperactivity of the hypothalamic-pituitary-adrenal axis and involve some unknown pathophysiologic processes of arenaviral infection. Furthermore, increased plasma catecholamine concentrations are associated with stress and may be partially responsible for the development of cardiovascular dysfunction and pulmonary edema during this viral disease. C1 UNIV TEXAS,HLTH SCI CTR,DEPT PHARMACOL,SAN ANTONIO,TX 78284. CYTOMED INC,CAMBRIDGE,MA 02139. CTR DIS CONTROL,SPECIAL PATHOGENS BRANCH,ATLANTA,GA 30333. USA,MED RES INST INFECT DIS,DEPT CLIN & EXPTL PHYSIOL,DIV DIS ASSESSMENT,FREDERICK,MD 21702. NR 35 TC 9 Z9 10 U1 0 U2 1 PU AMER ASSOC LABORATORY ANIMAL SCIENCE PI CORDOVA PA 70 TIMBERCREEK DR, SUITE 5, CORDOVA, TN 38018 SN 0023-6764 J9 LAB ANIM SCI JI Lab. Anim. Sci. PD DEC PY 1993 VL 43 IS 6 BP 569 EP 574 PG 6 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA MV091 UT WOS:A1993MV09100007 PM 8158981 ER PT J AU DUNN, DG AF DUNN, DG TI DIAGNOSTIC EXERCISE - INTESTINAL PARASITISM IN AN OWL MONKEY SO LABORATORY ANIMAL SCIENCE LA English DT Note RP DUNN, DG (reprint author), WALTER REED ARMY INST RES,DIV PATHOL,WASHINGTON,DC 20307, USA. FU NCRR NIH HHS [RR00301] NR 8 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC LABORATORY ANIMAL SCIENCE PI CORDOVA PA 70 TIMBERCREEK DR, SUITE 5, CORDOVA, TN 38018 SN 0023-6764 J9 LAB ANIM SCI JI Lab. Anim. Sci. PD DEC PY 1993 VL 43 IS 6 BP 622 EP 624 PG 3 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA MV091 UT WOS:A1993MV09100019 PM 8158993 ER PT J AU COCKMANTHOMAS, RA COLLETON, CA GARDINER, CH MEYERS, WM AF COCKMANTHOMAS, RA COLLETON, CA GARDINER, CH MEYERS, WM TI GNATHOSTOMIASIS IN A WILD-CAUGHT 9-BANDED ARMADILLO (DASYPUS- NOVEMCINCTUS) SO LABORATORY ANIMAL SCIENCE LA English DT Article C1 ARMED FORCES INST PATHOL,WASHINGTON,DC 20307. RP COCKMANTHOMAS, RA (reprint author), WALTER REED ARMY INST RES,WASHINGTON,DC 20307, USA. NR 3 TC 3 Z9 3 U1 0 U2 3 PU AMER ASSOC LABORATORY ANIMAL SCIENCE PI CORDOVA PA 70 TIMBERCREEK DR, SUITE 5, CORDOVA, TN 38018 SN 0023-6764 J9 LAB ANIM SCI JI Lab. Anim. Sci. PD DEC PY 1993 VL 43 IS 6 BP 630 EP 632 PG 3 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA MV091 UT WOS:A1993MV09100022 PM 8158995 ER PT J AU BARTH, J AF BARTH, J TI FIRE YOUR BROKER - ROFFMAN,MB, SCHWAGER,MJ SO LIBRARY JOURNAL LA English DT Book Review RP BARTH, J (reprint author), US MIL ACAD LIB,W POINT,NY, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 SN 0363-0277 J9 LIBR J JI Libr. J. PD DEC PY 1993 VL 118 IS 21 BP 140 EP 140 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA MM270 UT WOS:A1993MM27000142 ER PT J AU BURGESS, EB AF BURGESS, EB TI ADAM IN THE BREACH - FRASER,D SO LIBRARY JOURNAL LA English DT Book Review RP BURGESS, EB (reprint author), USA,CTR TRALINET,FT MONROE,VA, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 SN 0363-0277 J9 LIBR J JI Libr. J. PD DEC PY 1993 VL 118 IS 21 BP 173 EP 173 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA MM270 UT WOS:A1993MM27000279 ER PT J AU LANGSETH, M DELACA, T NEWTON, G COAKLEY, B COLONY, R GOSSETT, J MAY, C MCROY, P MORISON, J SMETHIE, W STEELE, D TUCKER, W AF LANGSETH, M DELACA, T NEWTON, G COAKLEY, B COLONY, R GOSSETT, J MAY, C MCROY, P MORISON, J SMETHIE, W STEELE, D TUCKER, W TI SCICEX-93 - ARCTIC CRUISE OF THE UNITED-STATES-NAVY NUCLEAR POWERED SUBMARINE USS-PARGO SO MARINE TECHNOLOGY SOCIETY JOURNAL LA English DT Article AB A nuclear powered submarie, USS Pargo, made a scientific cruise to the Arctic Ocean during the late summer of 1993. This was the first cruise of a nuclear submarine to the arctic in which the U.S. oceanographic community was openly invited to participate in the planning and implementation of the cruise. The data from the cruise will be placed in the public domain and results published in the open literature. During the cruise, called SCICEX-93, 9,080 km (4,900 nm) of underway data (bathymetry, gravity anomaly, temperature, salinity, ice draft, and images of the underside of the ice) were collected in the deep Arctic Ocean below the ice pack. Surface stations were occupied at 20 locations along the track. At these stations 35 CTD (conductivity, temperature, depth) casts were made in the shallow water of the Arctic Ocean (400-600 m), and 31 vertical current profiles were made using an expendable free-fall device. Bottle casts collected 1,500 water samples for chemical and biological analysis. While submerged, 31 submarine-launched, expendable CTDs were deployed and 46 water samples were drawn through the submarine's seawater system. Four buoys were deployed in the ice: two were used for meteorological observations and two polar oceanographic profiling buoys were used to make long-term time-series measurements of temperature and salinity at six different depths in the shallow water of the Arctic Ocean. The SCICEX-93 cruise demonstrated the remarkable potential of nuclear powered submarines for oceanographic and geophysical studies of ice covered regions of the ocean. C1 UNIV ALASKA,FAIRBANKS,AK 99701. SYST PLANNING CORP,ARLINGTON,VA. UNIV WASHINGTON,APPL PHYS LAB,CTR POLAR SCI,SEATTLE,WA 98195. ARCTIC SUBMARINE LAB,SAN DIEGO,CA. COLD REG RES & ENGN LAB,HANOVER,NH. RP LANGSETH, M (reprint author), COLUMBIA UNIV,LAMONT DOHERTY GEOL OBSERV,PALISADES,NY 10964, USA. NR 10 TC 3 Z9 3 U1 1 U2 3 PU MARINE TECHNOLOGY SOC INC PI WASHINGTON PA C/O I CLAYION MATTHEWS, 1828 L ST, NW, 9TH FL, WASHINGTON, DC 20036 SN 0025-3324 J9 MAR TECHNOL SOC J JI Mar. Technol. Soc. J. PD WIN PY 1993 VL 27 IS 4 BP 4 EP 12 PG 9 WC Engineering, Ocean; Oceanography SC Engineering; Oceanography GA NB554 UT WOS:A1993NB55400002 ER PT J AU OSWALD, RB AF OSWALD, RB TI DUAL-USE TECHNOLOGY - USING DEPARTMENT-OF-DEFENSE TECHNOLOGY TO SUPPORT MARINE RESEARCH SO MARINE TECHNOLOGY SOCIETY JOURNAL LA English DT Editorial Material RP OSWALD, RB (reprint author), USA,CORPS ENGINEERS,RES & DEV,WASHINGTON,DC 20310, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARINE TECHNOLOGY SOC INC PI WASHINGTON PA C/O I CLAYION MATTHEWS, 1828 L ST, NW, 9TH FL, WASHINGTON, DC 20036 SN 0025-3324 J9 MAR TECHNOL SOC J JI Mar. Technol. Soc. J. PD WIN PY 1993 VL 27 IS 4 BP 49 EP 51 PG 3 WC Engineering, Ocean; Oceanography SC Engineering; Oceanography GA NB554 UT WOS:A1993NB55400007 ER PT J AU KORROCH, RE DAVIDSON, MJ AF KORROCH, RE DAVIDSON, MJ TI JURY NULLIFICATION - A CALL FOR JUSTICE OR AN INVITATION TO ANARCHY SO MILITARY LAW REVIEW LA English DT Article C1 USA,LEGAL SERV AGCY,DIV LITIGAT,WASHINGTON,DC 20310. RP KORROCH, RE (reprint author), US COAST GUARD,CTR RESERVE TRAINING,YORKTOWN,VA 23691, USA. NR 30 TC 6 Z9 6 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD WIN PY 1993 VL 139 BP 131 EP 152 PG 22 WC Law SC Government & Law GA LU490 UT WOS:A1993LU49000003 ER PT J AU ADDICOTT, JF HUDSON, WA AF ADDICOTT, JF HUDSON, WA TI THE 25TH ANNIVERSARY OF MY-LAI - A TIME TO INCULCATE THE LESSONS SO MILITARY LAW REVIEW LA English DT Article RP ADDICOTT, JF (reprint author), USA,JUDGE ADVOCATE GEN CORPS,DIV INT & OPERAT LAW,WASHINGTON,DC 20310, USA. NR 52 TC 13 Z9 13 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD WIN PY 1993 VL 139 BP 153 EP 185 PG 33 WC Law SC Government & Law GA LU490 UT WOS:A1993LU49000004 ER PT J AU BORCH, FL AF BORCH, FL TI EISENHOWER AND THE GERMAN POWS - FACTS AGAINST FALSEHOODS - BISCHOF,G, AMBROSE,S SO MILITARY LAW REVIEW LA English DT Book Review RP BORCH, FL (reprint author), USA,JUDGE ADVOCATE GEN SCH,DIV CRIMINAL LAW,WASHINGTON,DC 20310, USA. NR 3 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD WIN PY 1993 VL 139 BP 187 EP 189 PG 3 WC Law SC Government & Law GA LU490 UT WOS:A1993LU49000005 ER PT J AU PARK, JJ AF PARK, JJ TI THE LITIGATION EXPLOSION - WHAT HAPPENED WHEN AMERICA UNLEASHED THE LAWSUIT - OLSON,WK SO MILITARY LAW REVIEW LA English DT Book Review RP PARK, JJ (reprint author), USA,JUDGE ADVOCATE GEN SCH,DIV CRIMINAL LAW,WASHINGTON,DC 20310, USA. NR 4 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD WIN PY 1993 VL 139 BP 190 EP 194 PG 5 WC Law SC Government & Law GA LU490 UT WOS:A1993LU49000006 ER PT J AU BORCH, FL AF BORCH, FL TI I COULD NEVER BE SO LUCKY AGAIN - DOOLITTLE,JH, GLINES,CV SO MILITARY LAW REVIEW LA English DT Book Review RP BORCH, FL (reprint author), USA,JUDGE ADVOCATE GEN SCH,DIV CRIMINAL LAW,WASHINGTON,DC 20310, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD WIN PY 1993 VL 139 BP 195 EP 198 PG 4 WC Law SC Government & Law GA LU490 UT WOS:A1993LU49000007 ER PT J AU BORCH, FL AF BORCH, FL TI FOLLOW ME, PT 2, MORE ON THE HUMAN ELEMENT IN LEADERSHIP - NEWMAN,AS SO MILITARY LAW REVIEW LA English DT Book Review RP BORCH, FL (reprint author), USA,JUDGE ADVOCATE GEN SCH,DIV CRIMINAL LAW,WASHINGTON,DC 20310, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD WIN PY 1993 VL 139 BP 198 EP 200 PG 3 WC Law SC Government & Law GA LU490 UT WOS:A1993LU49000008 ER PT J AU BORCH, FL AF BORCH, FL TI TRIAL PRACTICE - DUBIN,LA, GUERNSEY,TF SO MILITARY LAW REVIEW LA English DT Book Review RP BORCH, FL (reprint author), USA,JUDGE ADVOCATE GEN SCH,DIV CRIMINAL LAW,WASHINGTON,DC 20310, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD WIN PY 1993 VL 139 BP 204 EP 205 PG 2 WC Law SC Government & Law GA LU490 UT WOS:A1993LU49000010 ER PT J AU BORCH, FL AF BORCH, FL TI THUNDERBOLT - ABRAMS,CREIGHTON AND THE ARMY OF HIS TIMES - SORLEY,L SO MILITARY LAW REVIEW LA English DT Book Review RP BORCH, FL (reprint author), USA,JUDGE ADVOCATE GEN SCH,DIV CRIMINAL LAW,WASHINGTON,DC 20310, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD WIN PY 1993 VL 139 BP 205 EP 208 PG 4 WC Law SC Government & Law GA LU490 UT WOS:A1993LU49000011 ER PT J AU SALTER, CA CROWLEY, JS ALLAN, LW AF SALTER, CA CROWLEY, JS ALLAN, LW TI SLEEP-RELATED INJURIES IN THE US ARMY, 1984-1991 SO MILITARY MEDICINE LA English DT Article AB U.S. Army Safety Center files for the years 1984-1991 were searched for ground accidents involving sleeping soldiers. There were 68 incidents which could be so categorized, 53 of which resulted in injuries and 15 in fatalities. The average cost to the Army, adjusted to 1991 dollars, was $8,300 for each injury and $61,900 for each fatality. The injured required an average 24.6 days of lost duty time for recovery. The incidents most commonly occurred when soldiers slept near vehicles and less commonly when they slept in designated ''safe'' areas. With improved guidance and training, such accidents could be reduced. RP SALTER, CA (reprint author), USA,AEROMED RES LAB,DIV BIOMED APPLICAT RES,FT RUCKER,AL 36362, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD DEC PY 1993 VL 158 IS 12 BP 782 EP 785 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA MQ208 UT WOS:A1993MQ20800010 PM 8108017 ER PT J AU CLOUTIER, MG AF CLOUTIER, MG TI MEDICAL-CARE BEHIND ENEMY LINES - A HISTORICAL EXAMINATION OF CLANDESTINE HOSPITALS SO MILITARY MEDICINE LA English DT Article AB Current medical doctrine states that hospital support to unconventional forces will be provided by conventional medical units in the theater. During such operations, the tactical situation may preclude timely hospital care to the detriment of the patient and his unit's effectiveness. To find a viable solution, this study investigates the concept of clandestine hospitals employed during World War II and by North Vietnamese soldiers and Afghan resistance fighters. A test of the concept by a Special Forces Medical Detachment is also described. The characteristics of successful clandestine hospital operations and lessons learned are discussed. RP CLOUTIER, MG (reprint author), USA,MED DEPT CTR & SCH,FT SAM HOUSTON,TX 78234, USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD DEC PY 1993 VL 158 IS 12 BP 816 EP 820 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA MQ208 UT WOS:A1993MQ20800019 PM 8108026 ER PT J AU JENNINGS, BM AF JENNINGS, BM TI NURSING IMPLICATIONS OF THE DEPARTMENT-OF-DEFENSE COORDINATED CARE PROGRAM SO MILITARY MEDICINE LA English DT Article AB As the Department of Defense implements the Coordinated Care Program (CCP), it is essential to examine the implications of such a change for nursing. The nursing aspects of a CCP must be designed with consideration of nursing's contribution to patient care and hence the relationship of nursing to quality, access, and cost containment goals. In this paper, following an overview of the CCP, three major nursing implications of the CCP are identified and addressed. These are: (a) the cost of nursing, (b) the structure of nursing, and (c) the role of nurses. RP JENNINGS, BM (reprint author), USA,HLTH PROFESS SUPPORT AGCY,DIV CLIN POLICY,5111 LEESBURG PIKE,FALLS CHURCH,VA 22041, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD DEC PY 1993 VL 158 IS 12 BP 823 EP 827 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA MQ208 UT WOS:A1993MQ20800021 PM 8108028 ER PT J AU WOLFE, AD CHIANG, PK DOCTOR, BP FRYAR, N RHEE, JP SAEED, M AF WOLFE, AD CHIANG, PK DOCTOR, BP FRYAR, N RHEE, JP SAEED, M TI MONOCLONAL-ANTIBODY AE-2 MODULATES CARBAMATE AND ORGANOPHOSPHATE INHIBITION OF FETAL BOVINE SERUM ACETYLCHOLINESTERASE SO MOLECULAR PHARMACOLOGY LA English DT Article ID TORPEDO-CALIFORNICA; ANIONIC SUBSITES; CATALYTIC CENTER; IDENTIFICATION; PURIFICATION; SEQUENCE; ENZYME AB The monoclonal antibody AE-2, raised against the human erythrocyte acetylcholinesterase (AChE) dimer (acetylcholine acetylhydrolase, EC 3.1.1.7), binds to other mammalian AChEs, including the tetramer that occurs in fetal bovine serum (FBS). AE-2 partially inhibited the rate of hydrolysis of the charged substrate acetylthiocholine by FBS AChE, whereas it increased the rate of hydrolysis of the neutral substrate indophenyl acetate. Present results show that AE-2 decreases the rate of inhibition of FBS AChE by the positively charged organophosphate amiton-p-toluene sulfonate and the positively charged carbamates pyridostigmine and neostigmine but accelerates inhibition of FBS AChE by the neutral organophosphates paraoxon and diisopropylfluorophosphate. Results suggest that AE-2 may allosterically modulate an anionic site in the catalytic center of FBS AChE. RP WOLFE, AD (reprint author), WALTER REED ARMY INST RES,DIV BIOCHEM,WASHINGTON,DC 20307, USA. NR 25 TC 11 Z9 11 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0026-895X J9 MOL PHARMACOL JI Mol. Pharmacol. PD DEC PY 1993 VL 44 IS 6 BP 1152 EP 1157 PG 6 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA MN466 UT WOS:A1993MN46600009 PM 8264551 ER PT J AU KAPLAN, AJ AF KAPLAN, AJ TI COMPOSITE UNIMODALITY SO NAVAL RESEARCH LOGISTICS LA English DT Article AB This article defines a class of univariate functions termed composite unimodal, and shows how their minimization admits an effective search procedure, albeit one not as efficient as is Fibonacci search for unimodal functions. An approximate Lagrangian approach to an important real-world logistics problem is seen to yield a surrogate problem whose objective function is composite unimodal. The mathematical form of this objective function is likely to be encountered in solving future real-world problems. (C) 1993 John Wiley & Sons, Inc. RP KAPLAN, AJ (reprint author), USA,MAT SYST ANAL ACT,PHILADELPHIA,PA 19106, USA. NR 9 TC 0 Z9 0 U1 0 U2 0 PU JOHN WILEY & SONS INC PI NEW YORK PA 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0894-069X J9 NAV RES LOG JI Nav. Res. Logist. PD DEC PY 1993 VL 40 IS 7 BP 1003 EP 1011 DI 10.1002/1520-6750(199312)40:7<1003::AID-NAV3220400710>3.0.CO;2-D PG 9 WC Operations Research & Management Science SC Operations Research & Management Science GA MH076 UT WOS:A1993MH07600008 ER PT J AU PARKER, MF BOSSCHER, J BARNHILL, D PARK, R AF PARKER, MF BOSSCHER, J BARNHILL, D PARK, R TI OVARIAN MANAGEMENT DURING RADICAL HYSTERECTOMY IN THE PREMENOPAUSAL PATIENT - REPLY SO OBSTETRICS AND GYNECOLOGY LA English DT Letter RP PARKER, MF (reprint author), WALTER REED ARMY MED CTR,DEPT OBSTET & GYNECOL,GYNECOL ONCOL SERV,WASHINGTON,DC 20307, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0029-7844 J9 OBSTET GYNECOL JI Obstet. Gynecol. PD DEC PY 1993 VL 82 IS 6 BP 1042 EP 1043 PG 2 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA MH769 UT WOS:A1993MH76900032 ER PT J AU PARKER, MF BOSSCHER, J BARNHILL, D PARK, R AF PARKER, MF BOSSCHER, J BARNHILL, D PARK, R TI OVARIAN MANAGEMENT DURING RADICAL HYSTERECTOMY IN THE PREMENOPAUSAL PATIENT - REPLY SO OBSTETRICS AND GYNECOLOGY LA English DT Letter RP PARKER, MF (reprint author), WALTER REED ARMY MED CTR,DEPT OBSTET & GYNECOL,GYNECOL ONCOL SERV,WASHINGTON,DC 20307, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0029-7844 J9 OBSTET GYNECOL JI Obstet. Gynecol. PD DEC PY 1993 VL 82 IS 6 BP 1043 EP 1043 PG 1 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA MH769 UT WOS:A1993MH76900034 ER PT J AU CHEN, G MAZUMDER, MM CHEMLA, YR SERPENGUZEL, A CHANG, RK HILL, SC AF CHEN, G MAZUMDER, MM CHEMLA, YR SERPENGUZEL, A CHANG, RK HILL, SC TI WAVELENGTH VARIATION OF LASER-EMISSION ALONG THE ENTIRE RIM OF SLIGHTLY DEFORMED MICRODROPLETS SO OPTICS LETTERS LA English DT Article ID SCATTERING; MODES AB The frequencies of the normal azimuthal modes of a slightly deformed droplet that is axisymmetric about its flow direction are no longer degenerate but vary with position along the droplet rim. We measured the wavelength variation along the entire rim of a dye-lasing droplet with a spectrograph and a CCD array. We determined the amplitude and the shape of the droplet deformation from the observed and predicted parabolic dependence of wavelength variation with distance along the spectrograph slit. C1 YALE UNIV,CTR LASER DIAGNOST,NEW HAVEN,CT 06520. USA,RES LAB,WHITE SANDS MISSILE RANGE,NM 88002. NEW MEXICO STATE UNIV,LAS CRUCES,NM 88003. RP CHEN, G (reprint author), YALE UNIV,DEPT APPL PHYS,NEW HAVEN,CT 06520, USA. NR 8 TC 41 Z9 42 U1 0 U2 3 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0146-9592 J9 OPT LETT JI Opt. Lett. PD DEC 1 PY 1993 VL 18 IS 23 BP 1993 EP 1995 DI 10.1364/OL.18.001993 PG 3 WC Optics SC Optics GA MJ099 UT WOS:A1993MJ09900001 PM 19829469 ER PT J AU RUNGEE, JL AF RUNGEE, JL TI LOW-BACK-PAIN DURING PREGNANCY SO ORTHOPEDICS LA English DT Review RP RUNGEE, JL (reprint author), USA,MED ACT,ORTHOPED SURG SERV,SPECIAL FORCES GRP AIRBORNE 5,FT CAMPBELL,KY 42223, USA. NR 0 TC 17 Z9 17 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 SN 0147-7447 J9 ORTHOPEDICS JI Orthopedics PD DEC PY 1993 VL 16 IS 12 BP 1339 EP 1344 PG 6 WC Orthopedics SC Orthopedics GA ML619 UT WOS:A1993ML61900005 PM 8108283 ER PT J AU WISWELL, TE TENCER, HL WELCH, CA CHAMBERLAIN, JL AF WISWELL, TE TENCER, HL WELCH, CA CHAMBERLAIN, JL TI CIRCUMCISION IN CHILDREN BEYOND THE NEONATAL-PERIOD SO PEDIATRICS LA English DT Article DE CIRCUMCISION; BALANITIS; POSTHITIS; PHIMOSIS; URINARY TRACT INFECTION AB Objective. Although many boys are circumcised after the newborn period, there are limited data concerning the proportion of uncircumcised infants who subsequently have the procedure, as well as minimal information about characteristics of this population. Population. Data and medical records of boys born in US Army hospitals from 1985 through 1992 were reviewed. General information regarding a portion of the 32 072 boys who were not circumcised during their neonatal hospitalization, but subsequently had the procedure, is reported. In addition, specific details are presented about 476 boys who were circumcised after their birth hospitalization. Results. The postneonatal circumcision frequency rate of these children increased significantly over this period (P < .0001), particularly after the 1989 American Academy of Pediatrics statement on circumcision. In general, most boys were not circumcised as neonates because of parental choice (55%) or because of a complicated neonatal course (32%). ''Sleeve' and ''freehand' resection were the most common methods of circumcision (93%), and general anesthesia was used in 91% of the boys. The mean age at postneonatal circumcision was 2.92 years. Common reasons for the ensuing procedure included parental choice (39%), coincidence with other surgery (27%), recurrent balanoposthitis (23%), and urinary tract infections (7%). Complications occurred in 8 of the 476 boys whose specific records were reviewed. These included excessive bleeding (3), malignant hyperthermia (2), aspiration pneumonia (1), large hematoma development (1), and postoperative fever (1). Conclusions. An increasing number of boys are circumcised beyond the neonatal period, and the procedure performed at this time can be associated with substantial complications. This information may be of use when performing informed-consent counseling for neonatal circumcision. RP WISWELL, TE (reprint author), WALTER REED ARMY MED CTR,DEPT PEDIAT,DIV NEONATOL,1025 WALNUT ST,SUITE 700,WASHINGTON,DC 20307, USA. NR 9 TC 67 Z9 67 U1 0 U2 1 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD, ELK GROVE VILLAGE, IL 60007-1098 SN 0031-4005 J9 PEDIATRICS JI Pediatrics PD DEC PY 1993 VL 92 IS 6 BP 791 EP 793 PG 3 WC Pediatrics SC Pediatrics GA MJ565 UT WOS:A1993MJ56500007 PM 8233738 ER PT J AU MAEL, FA HIRSCH, AC AF MAEL, FA HIRSCH, AC TI RAIN-FOREST EMPIRICISM AND QUASI-RATIONALITY - 2 APPROACHES TO OBJECTIVE BIODATA SO PERSONNEL PSYCHOLOGY LA English DT Article; Proceedings Paper CT Annual Meeting of the American-Psychological-Association CY AUG, 1992 CL WASHINGTON, DC SP Amer Psychol Assoc ID BIOGRAPHICAL DATA; ACCURACY; VALIDITY; FAKING AB Two approaches to objective biodata, designed to achieve the interpretability and stability of rational approaches, yet minimize socially desirable responding, were explored. The first was a quasi-rational attempt to derive biodata analogs to an existing temperament measure, and then use them as rational scales. The second was a theory-based variant of criterion-referenced keying, termed rainforest empiricism. Both were utilized with two consecutive classes of U.S. Military Academy cadets (n= 2,565) to predict leadership performance over four rating periods. The biodata analogs to the temperament measure added incremental validity over the Academy's current admissions package and had significantly smaller correlations with a social desirability scale than their equivalent temperament scales. Scales developed with the rainforest approach had higher incremental validities and lower social desirability. Both methods demonstrated satisfactory stability upon cross-validation, and provided complementary interpretability. Advantages to each approach, and the implications for their use, are discussed. C1 NYNEX CORP,WHITE PLAINS,NY. RP MAEL, FA (reprint author), USA,RES INST,5001 EISENHOWER AVE,ALEXANDRIA,VA 22333, USA. NR 37 TC 34 Z9 34 U1 0 U2 2 PU PERSONNEL PSYCHOLOGY INC PI BOWLING GREEN PA 745 HASKINS ROAD, SUITE A, BOWLING GREEN, OH 43402 SN 0031-5826 J9 PERS PSYCHOL JI Pers. Psychol. PD WIN PY 1993 VL 46 IS 4 BP 719 EP 738 DI 10.1111/j.1744-6570.1993.tb01566.x PG 20 WC Psychology, Applied; Management SC Psychology; Business & Economics GA MP996 UT WOS:A1993MP99600001 ER PT J AU GRUBER, JB QUAGLIANO, JR REID, MF RICHARDSON, FS HILLS, ME SELTZER, MD STEVENS, SB MORRISON, CA ALLIK, TH AF GRUBER, JB QUAGLIANO, JR REID, MF RICHARDSON, FS HILLS, ME SELTZER, MD STEVENS, SB MORRISON, CA ALLIK, TH TI ENERGY-LEVELS AND CORRELATION CRYSTAL-FIELD EFFECTS IN ER3+-DOPED GARNETS SO PHYSICAL REVIEW B LA English DT Article ID F TRANSITION INTENSITIES; SPECTROSCOPIC ANALYSIS; PARAMETRIC ANALYSIS; UPCONVERSION LASER; ABSORPTION-SPECTRA; ER3+ IONS; ND-YLF; ND-3+; DIODE; Y3SC2AL3O12 AB The crystal-field energy-level structures of three different Er3+-doped garnet systems are analyzed and compared in this study. The garnet hosts are Y3Al5O12 (YAG), Y3Sc2Al3O12 (YSAG) doped with TM3+ as a sensitizer ion, and Y3Sc2Ga3O12 (YSGG) doped with Cr3+ as a sensitizer ion. The focus is on energy levels assigned to Er3+ ions substituted for Y3+ at dodecahedral (D2 SYmmetry) sites in the cubic gamet lattices. Analyses are carried out on experimental energy-level data that span up to 29 different 2S + 1L(J) multiplet manifolds (between 0 and 44 000 cm-1) of the Er3+ 4f11 electronic configuration. These data include the locations of 117 crystal-field levels of Er3+ in YAG, 109 levels of Er3+ in YSAG, and 92 levels of Er3+ in YSGG. The energy-level analyses are based on the use of a parametrized model Hamiltonian for the 4f11 electronic configuration of Er3+ in a crystal field of D2 symmetry. The model Hamiltonian includes both atomic (''free-ion'') and crystal-field interactions, parametrized to fit calculated eigenvalues to experimentally observed energies. The crystal-field part of the Hamiltonian is defined to include the standard one-electron interaction operators, as well as additional operators that provide a partial, phenomenological consideration of electron-correlation effects in the 4f-electron-crystal-field interactions. The latter, correlation crystal-field (CCF) interactions, are introduced to address crystal-field splittings within several J-multiplet manifolds that are poorly represented by one-electron crystal-field interaction models. Inclusion of CCF terms in the model Hamiltonian leads to dramatic improvement in the fits between calculated and observed crystal-field splittings within the problematic multiplet manifolds. All of the energy-level analyses reported in this study were carried out within commensurate parametrization schemes, and the Hamiltonian parameters derived from these analyses provide a suitable basis for comparing the 4f-electron-crystal-field interaction properties of Er3+ in YAG, YSAG, and YSGG. These analyses are based entirely on experimental data that specify the locations of energy levels, but do not provide any explicit information about the angular momentum (JM(J)) compositions of the crystal-field wave functions. C1 UNIV VIRGINIA,DEPT CHEM,CHARLOTTESVILLE,VA 22901. USN,CTR AIR WARFARE,RES DEPT,DIV CHEM,DIV WEAPONS,CHINA LAKE,CA 93555. USA,COMMAND LAB,HARRY DIAMOND LABS,ADELPHI,MD 20783. SCI APPLICAT INT CORP,MCLEAN,VA 22102. RP GRUBER, JB (reprint author), SAN JOSE STATE UNIV,DEPT PHYS,SAN JOSE,CA 95192, USA. OI Reid, Michael/0000-0002-2984-9951 NR 54 TC 102 Z9 105 U1 3 U2 25 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0163-1829 J9 PHYS REV B JI Phys. Rev. B PD DEC 1 PY 1993 VL 48 IS 21 BP 15561 EP 15573 DI 10.1103/PhysRevB.48.15561 PG 13 WC Physics, Condensed Matter SC Physics GA ML281 UT WOS:A1993ML28100005 ER PT J AU CORMIER, G CAPOBIANCO, JA MORRISON, CA MONTEIL, A AF CORMIER, G CAPOBIANCO, JA MORRISON, CA MONTEIL, A TI MOLECULAR-DYNAMICS SIMULATION OF THE TRIVALENT EUROPIUM ION DOPED IN SODIUM DISILICATE GLASS - ELECTRONIC ABSORPTION AND EMISSION-SPECTRA SO PHYSICAL REVIEW B LA English DT Article ID CRYSTAL-FIELD ANALYSIS; RARE-EARTH IONS; OPTICAL-SPECTRA; SILICATE-GLASSES; ENERGY-LEVELS; FLUORESCENCE; SPECTROSCOPY; COMPLEXES; EU-3+; SITES AB We report the simulation of the optical absorption and emission spectra of the Eu3+ ion doped in a sodium disilicate glass. A model of this glass was previously simulated by the molecular-dynamics technique. We employ a full treatment, including J mixing, of the point-charge crystal-field method developed for doped crystalline materials in order to simulate (1) the L-5(6), 5D3,2,1,0 <-- F-7(0,1) absorption spectrum and (2) the 5D0 --> F-7(0-6) emission spectrum of the Eu3+ ion. This produces simulated spectra with correct energies and relative intensities. A comparsion to experimental room-temperature absorption and fluorescence spectra of the corresponding laboratory glass is presented. By combining the simulated structural model with the calculated optical spectra, we are able to investigate spectra-structure correlations of doped inorganic glasses. C1 CONCORDIA UNIV,DEPT CHEM & BIOCHEM,1455 MAISONNEUVE BLVD W,MONTREAL H3G 1M8,QUEBEC,CANADA. USA,RES LAB,ADELPHI,MD 20783. UNIV LYON 1,F-69622 VILLEURBANNE,FRANCE. NR 67 TC 61 Z9 61 U1 0 U2 2 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0163-1829 J9 PHYS REV B JI Phys. Rev. B PD DEC 1 PY 1993 VL 48 IS 22 BP 16290 EP 16303 DI 10.1103/PhysRevB.48.16290 PG 14 WC Physics, Condensed Matter SC Physics GA MM350 UT WOS:A1993MM35000009 ER PT J AU TAYLOR, DC BASSETT, FH AF TAYLOR, DC BASSETT, FH TI SYNDESMOSIS ANKLE SPRAINS - DIAGNOSING THE INJURY AND AIDING RECOVERY SO PHYSICIAN AND SPORTSMEDICINE LA English DT Article AB Syndesmosis ankle sprains, though potentially disabling, often appear benign initially. These sprains are characterized by a rotational mechanism of injury, long recovery, and, frequently, heterotopic ossification. Diagnosis and grading are based on physical exam findings and imaging studies. Treatment ranges from aggressive functional rehabilitation to surgical stabilization. Long-term results can be good if the ankle mortise is anatomically reduced and a synostosis between the tibia and fibula does not form. RP TAYLOR, DC (reprint author), DWIGHT D EISENHOWER ARMY MED CTR,DIV ORTHOPAED SURG,SPORTS MED SERV,FT GORDON,GA 30905, USA. NR 0 TC 18 Z9 18 U1 0 U2 5 PU MCGRAW HILL HEALTHCARE PUBLICATIONS PI MINNEAPOLIS PA 4530 WEST 77TH ST, MINNEAPOLIS, MN 55435-5000 SN 0091-3847 J9 PHYSICIAN SPORTSMED JI Physician Sportsmed. PD DEC PY 1993 VL 21 IS 12 BP 39 EP & PG 0 WC Primary Health Care; Orthopedics; Sport Sciences SC General & Internal Medicine; Orthopedics; Sport Sciences GA MJ753 UT WOS:A1993MJ75300003 ER PT J AU BOLEY, TJ POPEK, EJ AF BOLEY, TJ POPEK, EJ TI PARVOVIRUS INFECTION IN PREGNANCY SO SEMINARS IN PERINATOLOGY LA English DT Review ID HYDROPS-FETALIS SECONDARY; POLYMERASE CHAIN-REACTION; SERUM ALPHA-FETOPROTEIN; SICKLE-CELL-ANEMIA; ERYTHEMA-INFECTIOSUM; APLASTIC CRISIS; B19 INFECTION; THROMBOCYTOPENIC PURPURA; INTRAUTERINE INFECTION; INSITU HYBRIDIZATION C1 TEXAS CHILDRENS HOSP,DEPT PATHOL,HOUSTON,TX 77030. RP BOLEY, TJ (reprint author), WALTER REED ARMY MED CTR,DEPT OBSTET & GYNECOL,WASHINGTON,DC 20307, USA. NR 81 TC 9 Z9 9 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0146-0005 J9 SEMIN PERINATOL JI Semin. Perinatol. PD DEC PY 1993 VL 17 IS 6 BP 410 EP 419 PG 10 WC Obstetrics & Gynecology; Pediatrics SC Obstetrics & Gynecology; Pediatrics GA MQ094 UT WOS:A1993MQ09400006 PM 8160025 ER PT J AU GRUBIN, HL GOVINDAN, TR KRESKOVSKY, JP AF GRUBIN, HL GOVINDAN, TR KRESKOVSKY, JP TI TRANSPORT VIA THE LIOUVILLE EQUATION AND MOMENTS OF QUANTUM DISTRIBUTION-FUNCTIONS SO SOLID-STATE ELECTRONICS LA English DT Article ID GAAS-MESFETS AB This paper (i) examines through numerical solutions of the coupled coordinate representation Liouville and Poisson equations, the use of the Bohm quantum potential to represent the equilibrium distribution of density and energy in quantum feature size structures; (ii) discusses the development of the nonequilibrium quantum hydrodynamic (QHD) equations with dissipation through the truncation of the quantum distribution function; and (iii) compares select results of the QHD equations incorporating the Bohm potential to the exact Liouville equation solutions. The broad conclusion of the study is that for structures of current interest such as HEMTs, only quantum mechanical solutions, or the incorporation of the quantum potential as a modification of the classical equations will permit representative solutions of such critical features as the sheet charge density. C1 USA,RES OFF,RES TRIANGLE PK,NC 27709. RP GRUBIN, HL (reprint author), SCI RES ASSOCIATES,POB 1058,GLASTONBURY,CT 06033, USA. NR 18 TC 23 Z9 23 U1 1 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0038-1101 J9 SOLID STATE ELECTRON JI Solid-State Electron. PD DEC PY 1993 VL 36 IS 12 BP 1697 EP 1709 DI 10.1016/0038-1101(93)90216-D PG 13 WC Engineering, Electrical & Electronic; Physics, Applied; Physics, Condensed Matter SC Engineering; Physics GA ML442 UT WOS:A1993ML44200007 ER PT J AU ROY, MJ AF ROY, MJ TI THE GERMAN HEALTH-CARE SYSTEM - MODEL OR MIRAGE SO SOUTHERN MEDICAL JOURNAL LA English DT Article ID COSTS AB Rising costs have spurred America's leaders to look abroad for a model upon which to pattern reform of our health care system. On the surface, at least, Germany would appear to have an ideal system combining universal access, high quality, free choice of physicians, and cost control. Germany has been particularly effective in curbing pharmaceutical and administrative expenses, and has avoided the progressive imbalance between primary care providers and medical specialists seen in America. However, Germany lags behind the US in emphasizing preventive services and in shifting services to the ambulatory setting. Also, an oversupply of physicians, lack of incentives to limit the volume of services, and a global budget cap have combined to induce physicians to do more while their incomes were falling sharply relative to those of other workers. Although selected elements of the German health care system could be beneficial to America, full-scale adoption of the German system is neither realistic nor desirable. C1 WALTER REED ARMY MED CTR,DEPT MED,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. NR 12 TC 4 Z9 4 U1 0 U2 0 PU SOUTHERN MEDICAL ASSN PI BIRMINGHAM PA 35 LAKESHORE DR PO BOX 190088, BIRMINGHAM, AL 35219 SN 0038-4348 J9 SOUTHERN MED J JI South.Med.J. PD DEC PY 1993 VL 86 IS 12 BP 1389 EP 1389 DI 10.1097/00007611-199312000-00014 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA MN622 UT WOS:A1993MN62200014 PM 8272918 ER PT J AU GIBSON, PW AF GIBSON, PW TI FACTORS INFLUENCING STEADY-STATE HEAT AND WATER-VAPOR TRANSFER MEASUREMENTS FOR CLOTHING MATERIALS SO TEXTILE RESEARCH JOURNAL LA English DT Article ID FABRICS; RESISTANCE; COMFORT; APPARATUS; TRANSPORT; TEXTILES AB Several techniques exist to evaluate the water vapor transport characteristics of clothing materials. The most common techniques include guarded hot plate sweating skin simulants and cup-type moisture vapor transmission rate tests. Theoretically, all such tests measure an identical property, water vapor resistance, but the results from different test methods rarely agree. The reasons for the discrepancies are the different conditions present in each test: in some cases the intrinsic properties of the materials are altered by the test conditions. The results of three studies illustrate important factors to be considered when evaluating the thermal and moisture vapor transport properties of textile materials. Each study concentrates on one particular aspect of the problems encountered in measuring relative performance characteristics of these materials. The first study involves an experimental correlation between two kinds of water vapor permeability tests. The second study looks at the influence of air permeability on heat and water vapor transport through woven and nonwoven fabrics. The final study determines the agreement between three different guarded hot plate (sweating skin simulant) test facilities that differ mainly in the air velocity over the test samples. RP GIBSON, PW (reprint author), USA,NATICK RES DEV & ENGN CTR,NATICK,MA 01760, USA. RI Gibson, Phillip/D-2398-2010 OI Gibson, Phillip/0000-0002-6172-4438 NR 52 TC 66 Z9 69 U1 5 U2 21 PU TEXTILE RESEARCH INST PI PRINCETON PA PO BOX 625, PRINCETON, NJ 08540 SN 0040-5175 J9 TEXT RES J JI Text. Res. J. PD DEC PY 1993 VL 63 IS 12 BP 749 EP 764 DI 10.1177/004051759306301208 PG 16 WC Materials Science, Textiles SC Materials Science GA MQ435 UT WOS:A1993MQ43500008 ER PT J AU WARTOFSKY, L AF WARTOFSKY, L TI HAS THE USE OF ANTITHYROID DRUGS FOR GRAVES-DISEASE BECOME OBSOLETE SO THYROID LA English DT Review ID SPONTANEOUS LYMPHOCYTIC THYROIDITIS; HLA-DR EXPRESSION; PERIPHERAL-BLOOD LYMPHOCYTES; HEAT-SHOCK PROTEIN; T-CELL SUBSETS; PRONE BB/W RAT; RETROOCULAR FIBROBLASTS; AUTOANTIBODY SYNTHESIS; DIETARY IODINE; STIMULATING IMMUNOGLOBULINS AB In spite of an experience of almost 50 years of use of antithyroid drugs and radioiodine for the treatment of Graves' disease, the rationale for choice is often obscure. Early reports of high remission rates during thiourea therapy were followed by less optimistic ones, which along with other factors may have fueled the current major shift toward use of radioiodine. This review examines whether or not the use of antithyroid drugs indeed may have become obsolete. The intrathyroidal and extrathyroidal mechanisms of action of the drugs are reviewed with emphasis on their potential immunosuppressive effects. The latter may involve a direct effect on thyroid follicular cells, a direct suppression of TSH receptor antibody formation, or indirect effects mediated via heat shock proteins, oxygen free radicals, and the immune system. Potential factors associated with success or failure with antithyroid drug therapy are discussed, such as the effects of dose and duration of treatment, iodine milieu, and concomitant L-thyroxine therapy. The risks inherent to radioiodine therapy are only briefly described with emphasis on the possible aggravation by radioiodine of preexistent ophthalmopathy. The reader must decide whether the evidence marshalled convincingly indicates that the use of the thiourea compounds should be abandoned. The author thinks not, and is optimistic that imminent discovery of the yet elusive and enigmatic pathogenesis of Graves' disease will permit new and innovative treatment or more effective use of currently available therapies. C1 UNIFORMED SERV UNIV HLTH SCI,DEPT MED & PHYSIOL,BETHESDA,MD 20814. RP WARTOFSKY, L (reprint author), WALTER REED ARMY MED CTR,DEPT MED,WASHINGTON,DC 20307, USA. NR 132 TC 19 Z9 19 U1 0 U2 1 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 1050-7256 J9 THYROID JI Thyroid PD WIN PY 1993 VL 3 IS 4 BP 335 EP 344 DI 10.1089/thy.1993.3.335 PG 10 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA MQ061 UT WOS:A1993MQ06100015 PM 7509673 ER PT J AU BLANK, JA HOBSON, DW SNIDER, TS MENTON, RG OLSON, CT KORTE, DW AF BLANK, JA HOBSON, DW SNIDER, TS MENTON, RG OLSON, CT KORTE, DW TI ACETYLCHOLINESTERASE INHIBITION MEASUREMENTS FOR THE EVALUATION OF DECONTAMINANT EFFICACY FOLLOWING PERCUTANEOUS ORGANOPHOSPHORUS COMPOUND EXPOSURE SO TOXICOLOGY METHODS LA English DT Article DE ORGANOPHOSPHONATE; ACETYLCHOLINESTERASE; INHIBITION AB A rapid and sensitive in vivo method for the evaluation of skin decontaminant efficacy following percutaneous exposure to organophosphonates (OPs) was developed using erythrocyte acetylcholinesterase (AChE; EC 3.1.1.7) inhibition in the rabbit as an end point. The level of AChE inhibition was evaluated for use as a more humane means of assessing skin decontaminant efficacy than lethality-based methods. Groups of anesthetized animals were exposed percutaneously to either of two highly toxic OPs [thickened soman (TGD) or VX], and 2 min later were treated with a known effective skin decontaminant or were untreated (negative control). Blood samples were drawn and assayed for AChE activity 5 min before TGD or VX exposure and at 30, 60, and 120 min after exposure. Percent AChE inhibition relative to preexposure levels was calculated at each postexposure time for each animal in control and treatment groups. Efficacy data based on percent AChE inhibition were compared with results from previous efficacy studies performed with the same decontaminants using 24-h lethality rate as the end point for evaluation. A high correlation between the findings for the two end points demonstrated that AChE inhibition can replace lethality as an end point in the routine evaluation of candidate skin decontaminants against OP compounds. Efficacy data based on the AChE end point were compared with results from previous efficacy studies performed with the same decontaminants using 24-h lethality rate as the end point for evaluation. C1 USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010. RP BLANK, JA (reprint author), BATTELLE MEM INST,505 KING AVE,COLUMBUS,OH 43201, USA. NR 10 TC 1 Z9 1 U1 0 U2 1 PU TAYLOR & FRANCIS PI BRISTOL PA 1900 FROST ROAD, SUITE 101, BRISTOL, PA 19007-1598 SN 1051-7235 J9 TOXICOL METHOD JI Toxicol. Method. PD DEC PY 1993 VL 3 IS 4 BP 252 EP 260 DI 10.3109/15376519309068442 PG 9 WC Toxicology SC Toxicology GA MH844 UT WOS:A1993MH84400002 ER PT J AU TAYLOR, DN ECHEVERRIA, P AF TAYLOR, DN ECHEVERRIA, P TI MOLECULAR BIOLOGICAL APPROACHES TO THE EPIDEMIOLOGY OF DIARRHEAL DISEASES IN DEVELOPING-COUNTRIES SO TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE LA English DT Article; Proceedings Paper CT Symposium on Diarrhoeal Disease : Current Concepts and Future Challenges CY JAN 06, 1993 CL LONDON, UNITED KINGDOM SP ROYAL SOC TROPI MED & HYGIENE, US NAVAL MED RES UNIT NUMBER 3, PATHOL SOC GREAT BRITAIN ID ENTEROINVASIVE ESCHERICHIA-COLI; DNA HYBRIDIZATION; DIARRHEAL DISEASE; THAILAND; ENTEROPATHOGENS; CHILDREN; SHIGELLA; GASTROENTERITIS; INFECTIONS; DYSENTERY AB Diarrhoea in developing countries is caused by an increasingly long list of bacterial, viral, and parasitic pathogens with rotavirus, enterotoxigenic Escherichia coli, Campylobacter, Shigella, and Salmonella heading the list. Using methods to detect most of the known enteropathogens, one or more enteropathogen(s) is isolated in two-thirds of diarrhoeal illnesses in the developing world. Many of these enteropathogens are also frequently isolated from children without diarrhoea. An aetiologic agent is more frequently isolated from cases of invasive diarrhoea than from those with secretory diarrhoea. Deoxyribonucleic acid probes have proved very useful in detecting pathogens such as enterotoxigenic (ETEC), enteroinvasive (ETEC), and enteropathogenic E. coli (EPEC), but have not yet proved to be particularly rapid or less expensive. Molecular biology has proved useful in epidemiological studies as a means of strain identification. Plasmids were initially used as convenient markers and proved useful in identifying epidemic strains of bacteria. Other molecular markers, such as ribotyping, are accurate enough to be used as taxonomic tools. C1 ARMED FORCES RES INST MED SCI,DEPT BACTERIOL,BANGKOK 10400,THAILAND. RP TAYLOR, DN (reprint author), WALTER REED ARMY INST RES,DEPT ENTER INFECT,WASHINGTON,DC 20307, USA. NR 21 TC 7 Z9 8 U1 0 U2 1 PU ROYAL SOC TROPICAL MEDICINE PI LONDON PA MANSON HOUSE 26 PORTLAND PLACE, LONDON, ENGLAND W1N 4EY SN 0035-9203 J9 T ROY SOC TROP MED H JI Trans. Roy. Soc. Trop. Med. Hyg. PD DEC PY 1993 VL 87 SU 3 BP 3 EP 5 DI 10.1016/0035-9203(93)90528-X PG 3 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA MM104 UT WOS:A1993MM10400002 PM 8108846 ER PT J AU MEISELMAN, HL AF MEISELMAN, HL TI 11TH INTERNATIONAL-CONFERENCE ON THE PHYSIOLOGY OF FOOD AND FLUID INTAKE SO TRENDS IN FOOD SCIENCE & TECHNOLOGY LA English DT Editorial Material RP MEISELMAN, HL (reprint author), USA,CTR RES DEV & ENGN,NATICK,MA 01760, USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB SN 0924-2244 J9 TRENDS FOOD SCI TECH JI Trends Food Sci. Technol. PD DEC PY 1993 VL 4 IS 12 BP 412 EP 413 DI 10.1016/0924-2244(93)90046-D PG 2 WC Food Science & Technology SC Food Science & Technology GA MP738 UT WOS:A1993MP73800005 ER PT J AU WANG, M PENNOCK, DG SPIK, KW SCHMALJOHN, CS AF WANG, M PENNOCK, DG SPIK, KW SCHMALJOHN, CS TI EPITOPE MAPPING STUDIES WITH NEUTRALIZING AND NONNEUTRALIZING MONOCLONAL-ANTIBODIES TO THE G1 AND G2 ENVELOPE GLYCOPROTEINS OF HANTAAN VIRUS SO VIROLOGY LA English DT Article ID HEMORRHAGIC-FEVER; GENOME SEGMENT; RENAL SYNDROME; ANTIGENIC DETERMINANTS; NUCLEOTIDE-SEQUENCE; CODING STRATEGY; VACCINIA VIRUS; S-GENOME; RNA; BACULOVIRUS C1 USA,MED RES INST INFECT DIS,DIV VIROL,FREDERICK,MD 21702. NR 17 TC 34 Z9 46 U1 0 U2 1 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0042-6822 J9 VIROLOGY JI Virology PD DEC PY 1993 VL 197 IS 2 BP 757 EP 766 DI 10.1006/viro.1993.1652 PG 10 WC Virology SC Virology GA MH092 UT WOS:A1993MH09200028 PM 7504368 ER PT J AU GUERTNER, GL AF GUERTNER, GL TI DETERRENCE AND CONVENTIONAL MILITARY FORCES SO WASHINGTON QUARTERLY LA English DT Article RP GUERTNER, GL (reprint author), USA,COLL WAR,INST STRATEG STUDIES,WASHINGTON,DC 20310, USA. NR 14 TC 2 Z9 2 U1 0 U2 1 PU MIT PRESS PI CAMBRIDGE PA 55 HAYWARD ST JOURNALS DEPT, CAMBRIDGE, MA 02142 SN 0163-660X J9 WASH QUART JI Wash. Q. PD WIN PY 1993 VL 16 IS 1 BP 141 EP 151 PG 11 WC International Relations; Law SC International Relations; Government & Law GA KC075 UT WOS:A1993KC07500010 ER PT J AU SAXENA, A DOCTOR, BP MAXWELL, DM LENZ, DE RADIC, Z TAYLOR, P AF SAXENA, A DOCTOR, BP MAXWELL, DM LENZ, DE RADIC, Z TAYLOR, P TI THE ROLE OF GLUTAMATE-199 IN THE AGING OF CHOLINESTERASE SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS LA English DT Article ID ACETYLCHOLINESTERASE; BRAIN C1 WALTER REED ARMY INST RES,DIV BIOCHEM,WASHINGTON,DC 20307. USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010. UNIV CALIF SAN DIEGO,DEPT PHARMACOL,LA JOLLA,CA 92093. NR 16 TC 48 Z9 48 U1 1 U2 2 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0006-291X J9 BIOCHEM BIOPH RES CO JI Biochem. Biophys. Res. Commun. PD NOV 30 PY 1993 VL 197 IS 1 BP 343 EP 349 DI 10.1006/bbrc.1993.2481 PG 7 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA MJ884 UT WOS:A1993MJ88400050 PM 7902714 ER PT J AU WEERASOORIYA, T BEAULIEU, PA AF WEERASOORIYA, T BEAULIEU, PA TI EFFECTS OF STRAIN-RATE ON THE DEFORMATION AND FAILURE BEHAVIOR OF 93WT-PERCENT-W-5WT-PERCENT-NI-2WT-PERCENT-FE UNDER SHEAR LOADING SO MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING LA English DT Article ID METALS AB A tungsten heavy alloy containing 93wt.%W (Teledyne 93wt.%W-5wt.%Ni-2wt.%Fe alloy swaged to 17%) was tested in torsion from quasi-static to high strain rates of loading. High strain rate tests were conducted using a torsional split-Hopkinson-bar apparatus. The results from these tests show that the yield and failure strengths of this alloy increase with increasing strain rate. The strain to failure decreases with increasing strain rate. At a strain rate of 600 s-1, the flow stress decreases with increasing strain, indicating that thermal softening dominates over both strain and strain rate hardening of the material at high strain rates of deformation. The instability that leads to the initiation of failure at high rates is a result of the formation of a localized shear band. The width of the intense shear zone of deformation decreases with increasing shear strain rate, reaching a limiting width of one to two grains at high strain rates. As the shear strain rate is increased, there is a reduction in the number of cleavage and brittle grain boundary fracture zones. The results under dynamic conditions show that the 93wt.%W alloy deforms and fails quite differently compared with that under slow rates of shear loading. RP WEERASOORIYA, T (reprint author), USA,RES LAB,MAT DYNAM BRANCH,WATERTOWN,MA 02172, USA. NR 17 TC 17 Z9 17 U1 0 U2 1 PU ELSEVIER SCIENCE SA LAUSANNE PI LAUSANNE 1 PA PO BOX 564, 1001 LAUSANNE 1, SWITZERLAND SN 0921-5093 J9 MAT SCI ENG A-STRUCT JI Mater. Sci. Eng. A-Struct. Mater. Prop. Microstruct. Process. PD NOV 30 PY 1993 VL 172 IS 1-2 BP 71 EP 78 DI 10.1016/0921-5093(93)90427-G PG 8 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Science & Technology - Other Topics; Materials Science; Metallurgy & Metallurgical Engineering GA MJ647 UT WOS:A1993MJ64700008 ER PT J AU GERBER, GS THISTED, R CHODAK, GW THOMPSON, IM AF GERBER, GS THISTED, R CHODAK, GW THOMPSON, IM TI DISEASE-SPECIFIC SURVIVAL FOLLOWING ROUTINE PROSTATE-CANCER SCREENING BY DIGITAL RECTAL EXAMINATION - CORRECTED PATIENT CLASSIFICATION SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Letter C1 BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234. RP GERBER, GS (reprint author), UNIV CHICAGO,CHICAGO,IL 60637, USA. RI Thisted, Ronald/B-1985-2008 NR 3 TC 1 Z9 1 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD NOV 24 PY 1993 VL 270 IS 20 BP 2437 EP 2437 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA MG671 UT WOS:A1993MG67100023 PM 8230618 ER PT J AU CROWE, MA JAMES, WD AF CROWE, MA JAMES, WD TI X-LINKED ICHTHYOSIS SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Editorial Material ID STEROID SULFATASE DEFICIENCY; DELETIONS; CDNA C1 WALTER REED ARMY MED CTR,DERMATOL SERV,WASHINGTON,DC 20307. NR 7 TC 3 Z9 3 U1 0 U2 1 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD NOV 17 PY 1993 VL 270 IS 19 BP 2265 EP 2266 DI 10.1001/jama.270.19.2265 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA MF993 UT WOS:A1993MF99300001 PM 8230579 ER PT J AU RAVINDRA, NM WU, Y SHAH, B SAVIN, W FINK, T LAREAU, RT PFEFFER, RL AF RAVINDRA, NM WU, Y SHAH, B SAVIN, W FINK, T LAREAU, RT PFEFFER, RL TI FORMATION OF TISI2/N(+)/P-SILICON JUNCTIONS BY IMPLANTATION THROUGH METAL TECHNIQUE SO PHYSICA STATUS SOLIDI A-APPLIED RESEARCH LA English DT Article ID SHALLOW-JUNCTION; SILICIDE AB Experimental studies of the formation and electrical characterization of TiSi2/n(+)/p-Si shallow junctions are presented. The formation of shallow n(+)-p junction, by ion implantation of As+ through Ti films evaporated on p-Si substrates followed by rapid thermal annealing (RTA) and conventional furnace annealing, is performed in these experiments. Structural techniques such as secondary ion mass spectroscopy (SIMS) and Rutherford backscattering (RBS) experiments are employed to characterize these devices. RUMP simulations are deployed to analyze and interpret the RBS data. Temperature dependent current-voltage measurements of these junctions are performed in the temperature range of 250 to 400 K. Interpretations for these results are sought from conventional p-n junction theory. C1 USA,RES LABS,FT MONMOUTH,NJ 07703. RP RAVINDRA, NM (reprint author), NEW JERSEY INST TECHNOL,UNIV HTS,NEWARK,NJ 07102, USA. NR 15 TC 0 Z9 0 U1 0 U2 0 PU AKADEMIE VERLAG GMBH PI BERLIN PA MUHLENSTRASSE 33-34, D-13187 BERLIN, GERMANY SN 0031-8965 J9 PHYS STATUS SOLIDI A JI Phys. Status Solidi A-Appl. Res. PD NOV 16 PY 1993 VL 140 IS 1 BP 283 EP 293 DI 10.1002/pssa.2211400128 PG 11 WC Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter SC Materials Science; Physics GA MM008 UT WOS:A1993MM00800027 ER PT J AU RYAN, EH MOORE, WJ AF RYAN, EH MOORE, WJ TI SILICONE BREAST IMPLANTS AND ATYPICAL AUTOIMMUNE-DISEASE SO ANNALS OF INTERNAL MEDICINE LA English DT Letter ID AUGMENTATION MAMMOPLASTY; SCLERODERMA RP RYAN, EH (reprint author), DWIGHT D EISENHOWER ARMY MED CTR,FT GORDON,GA 30905, USA. NR 5 TC 2 Z9 2 U1 0 U2 0 PU AMER COLL PHYSICIANS PI PHILADELPHIA PA INDEPENDENCE MALL WEST 6TH AND RACE ST, PHILADELPHIA, PA 19106-1572 SN 0003-4819 J9 ANN INTERN MED JI Ann. Intern. Med. PD NOV 15 PY 1993 VL 119 IS 10 BP 1053 EP 1054 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA MG672 UT WOS:A1993MG67200024 PM 8214990 ER PT J AU BYRD, JC HARGIS, JB KESTER, K HOSPENTHAL, DR WEIDNER, S DIEHL, L AF BYRD, JC HARGIS, JB KESTER, K HOSPENTHAL, DR WEIDNER, S DIEHL, L TI FLUDARABINE THERAPY FOR LYMPHOID MALIGNANCIES IS ASSOCIATED WITH A HIGH NUMBER OF OPPORTUNISTIC PULMONARY INFECTIONS SO BLOOD LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. RI Kester, Kent/A-2114-2011 OI Kester, Kent/0000-0002-5056-0802 NR 0 TC 3 Z9 3 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0006-4971 J9 BLOOD JI Blood PD NOV 15 PY 1993 VL 82 IS 10 SU 1 BP A138 EP A138 PG 1 WC Hematology SC Hematology GA MJ682 UT WOS:A1993MJ68200538 ER PT J AU COOPER, LI BILLUPS, LC BURGESS, DP PRYZBYLIK, JM MAYBEE, DA SALATA, KF AF COOPER, LI BILLUPS, LC BURGESS, DP PRYZBYLIK, JM MAYBEE, DA SALATA, KF TI LYSIS METHOD TO ASSIST PHENOTYPING OF CHRONICALLY TRANSFUSED SICKLE-CELL-ANEMIA PATIENTS, UTILIZING FLOW-CYTOMETRY SO BLOOD LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,PEDIAT HEMATOL ONCOL SERV,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0006-4971 J9 BLOOD JI Blood PD NOV 15 PY 1993 VL 82 IS 10 SU 1 BP A588 EP A588 PG 1 WC Hematology SC Hematology GA MJ682 UT WOS:A1993MJ68202334 ER PT J AU HAMELINK, JK BARR, CF JACKSON, MR TANG, DB GOMEZ, ER ALVING, BM AF HAMELINK, JK BARR, CF JACKSON, MR TANG, DB GOMEZ, ER ALVING, BM TI EFFECTS OF HIRULOG(TM) AND ASPIRIN ON PLATELET DEPOSITION IN A RAT CAROTID ENDARTERECTOMY MODEL SO BLOOD LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,DEPT SURG,WASHINGTON,DC 20307. WALTER REED ARMY INST RES,DEPT BIOMETR & STAT,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0006-4971 J9 BLOOD JI Blood PD NOV 15 PY 1993 VL 82 IS 10 SU 1 BP A283 EP A283 PG 1 WC Hematology SC Hematology GA MJ682 UT WOS:A1993MJ68201117 ER PT J AU KARK, JA WARD, FT GARDNER, JW AF KARK, JA WARD, FT GARDNER, JW TI SICKLE-CELL TRAIT INCREASES MORTALITY FROM EXERTIONAL HEAT ILLNESS SO BLOOD LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WALTER REED INST RES,DEPT MED,DEPT CLIN PHYSIOL,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,DIV PREVENT MED,BETHESDA,MD 20814. NR 1 TC 0 Z9 0 U1 0 U2 1 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0006-4971 J9 BLOOD JI Blood PD NOV 15 PY 1993 VL 82 IS 10 SU 1 BP A355 EP A355 PG 1 WC Hematology SC Hematology GA MJ682 UT WOS:A1993MJ68201402 ER PT J AU SANTOS, MT VALLES, J AZNAR, J MARCUS, AJ BROEKMAN, MJ SAFIER, LB AF SANTOS, MT VALLES, J AZNAR, J MARCUS, AJ BROEKMAN, MJ SAFIER, LB TI LOW-DOSE ASPIRIN FAILS TO BLOCK PROTHROMBOTIC EFFECTS OF ERYTHROCYTES SO BLOOD LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,DEPT BIOMETR & STAT,WASHINGTON,DC 20307. UNIV HOSP LA FE,RES CTR,VALENCIA,SPAIN. CORNELL UNIV,MED CTR,COLL MED,DEPT MED,NEW YORK,NY 10021. CORNELL UNIV,MED CTR,COLL MED,DEPT PATHOL,NEW YORK,NY 10021. DEPT VET AFFAIRS MED CTR,NEW YORK,NY. NR 2 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0006-4971 J9 BLOOD JI Blood PD NOV 15 PY 1993 VL 82 IS 10 SU 1 BP A283 EP A283 PG 1 WC Hematology SC Hematology GA MJ682 UT WOS:A1993MJ68201118 ER PT J AU WANG, FS COSGRIFF, TM BUNNER, DL MEREISH, KA AF WANG, FS COSGRIFF, TM BUNNER, DL MEREISH, KA TI EFFECTS OF AN ATTENUATED STRAIN OF JUNIN VIRUS ON PRODUCTION OF COAGULANT AND ANTICOAGULANT PROTEINS BY HEP G(2)-CELLS SO BLOOD LA English DT Meeting Abstract C1 USA,MED RES INST INFECT DIS,DIV MED,FREDERICK,MD 21701. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0006-4971 J9 BLOOD JI Blood PD NOV 15 PY 1993 VL 82 IS 10 SU 1 BP A600 EP A600 PG 1 WC Hematology SC Hematology GA MJ682 UT WOS:A1993MJ68202384 ER PT J AU PEOPLES, GE DAVEY, MP GOEDEGEBUURE, PS SCHOOF, DD EBERLEIN, TJ AF PEOPLES, GE DAVEY, MP GOEDEGEBUURE, PS SCHOOF, DD EBERLEIN, TJ TI T-CELL RECEPTOR V-BETA-2 AND V-BETA-6 MEDIATE TUMOR-SPECIFIC CYTOTOXICITY BY TUMOR-INFILTRATING LYMPHOCYTES IN OVARIAN-CANCER SO JOURNAL OF IMMUNOLOGY LA English DT Article ID RESTRICTED ANTIGEN RECEPTOR; AUREUS TOXIN SUPERANTIGENS; BETA GENE USAGE; V-BETA; AUTOIMMUNE ENCEPHALOMYELITIS; HUMAN-MELANOMA; PREDOMINANT EXPRESSION; LIMITED HETEROGENEITY; VARIABLE REGION; HLA-A AB The interaction between T lymphocytes and the Ag-HLA complex on tumor cells is mediated by the TCR. The diversity and the specificity of the TCR are in part secondary to the gene rearrangement of the V region on the beta-chain (Vbeta). To determine whether a restricted number of TCR Vbeta genes are utilized in the recognition of ovarian cancer, tumor-infiltrating lymphocytes (TIL) were isolated from six consecutive untreated ovarian cancer patients. TIL were also cultured using repeated autologous tumor stimulation, and by 7 wk, five of six patients produced bulk cultures consisting of >50% CD8+ T cells and demonstrating an autologous tumor-specific pattern of cytotoxicity. TCR Vbeta gene usage was analyzed in the five patients yielding fresh TIL and corresponding 7-wk cultured, tumor-specific TIL; 22 primers specific for 20 TCR Vbeta gene families were employed and amplified by polymerase chain reaction and then quantitated by HPLC. A hetergeneous pattern of Vbeta usage was seen in the fresh TIL; however, Vbeta2, Vbeta3, Vbeta6, Vbeta7, Vbeta8, and Vbeta13.1 were found in increased proportions in at least three of five patients. In the 7-wk tumor-specific TIL, Vbeta analysis showed an increased usage of Vbeta2, Vbeta3, Vbeta6, and Vbeta7 in more than three of five patients. No significant change in Vbeta representation was seen in control populations that were not stimulated with tumor. Looking at the percent change in Vbeta usage between fresh and 7-wk tumor-specific cultures, Vbeta2 and Vbeta6 were augmented significantly in at least three of five patients (108% and 61%, respectively). To verify that the increase in representation of these Vbeta families was responsible for the increased cytotoxicity observed, mAb specific for Vbeta2 and Vbeta6 were used to block tumor lysis. Anti-Vbeta6 and anti-Vbeta2 significantly blocked cytotoxicity against autologous tumor cells in those TIL populations expressing increased levels of these Vbeta families. These data suggest that a selective repertoire of TCR Vbeta genes is used to recognize the Ag-HLA class I complexes on the surface of ovarian tumor cells, and specifically Vbeta2 and Vbeta6 appear to mediate antitumor activity. These findings may aid in the development of a more specific immunotherapy in ovarian cancer. C1 HARVARD UNIV,BRIGHAM & WOMENS HOSP,SCH MED,DEPT SURG,DIV SURG ONCOL,75 FRANCIS ST,BOSTON,MA 02115. USA,DEPT MED,STUDENT DETACHMENT,FT SAM HOUSTON,TX 78234. DEPT VET AFFAIRS MED CTR,PORTLAND,OR 97207. OREGON HLTH SCI UNIV,PORTLAND,OR 97201. FU NCI NIH HHS [CA09535, R01 CA45484] NR 41 TC 36 Z9 36 U1 0 U2 0 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD NOV 15 PY 1993 VL 151 IS 10 BP 5472 EP 5480 PG 9 WC Immunology SC Immunology GA MF995 UT WOS:A1993MF99500037 PM 8228239 ER PT J AU PEOPLES, GE GOEDEGEBUURE, PS ANDREWS, JVR SCHOOF, DD EBERLEIN, TJ AF PEOPLES, GE GOEDEGEBUURE, PS ANDREWS, JVR SCHOOF, DD EBERLEIN, TJ TI HLA-A2 PRESENTS SHARED TUMOR-ASSOCIATED ANTIGENS DERIVED FROM ENDOGENOUS PROTEINS IN OVARIAN-CANCER SO JOURNAL OF IMMUNOLOGY LA English DT Article ID T-CELL CLONES; TOXIC LYMPHOCYTES-T; INFILTRATING LYMPHOCYTES; AUTOLOGOUS TUMOR; HUMAN-MELANOMA; BREFELDIN-A; MONOCLONAL-ANTIBODIES; ALLOGENEIC MELANOMAS; METASTATIC MELANOMA; CYTOLYTIC ACTIVITY AB Tumor-associated lymphocytes (TAL) from the malignant ascites and tumor-infiltrating lymphocytes (TIL) from the solid tumor were isolated from six consecutive untreated ovarian cancer patients. Tumor-specific CTL were generated from both TAL and TIL using solid phase anti-CD3, low dose IL-2 (50 IU/ml), and repeated tumor stimulation. The specificity of TAL and TIL was tested in standard cytotoxicity assays using autologous tumor, several allogeneic ovarian tumors, and the NK-sensitive cell line, K562. Anti-HLA-A-B-C mAb, W6/32, was used to demonstrate that these tumor-specific TAL and TIL were HLA class I-restricted. The ability of the ascitic and solid tumor to present Ag by HLA class I was assessed using Brefeldin A, a fungal metabolite that blocks the endogenous Ag-processing pathway in the viral model. Brefeldin A significantly inhibited tumor-specific cytotoxicity as well as HLA class I expression on the cell surface, suggesting an endogenous source of tumor-associated Ag. Despite previous reports of antigenic heterogeneity in ovarian cancer, shared tumor-associated Ag were shown to exist in this disease as demonstrated by significant allogeneic recognition of HLA-A2-matched patients as opposed to unmatched controls. Specifically, CTL from HLA-A2+ patients lysed HLA-A2+ allogeneic targets significantly better than HLA-A2- allogeneic or HLA-A2+ melanoma targets. There was no such difference with HLA-A2- effectors. Furthermore, HLA-A2 was confirmed to be a major restriction element in ovarian cancer by the blocking of HLA-A2+ effectors against both autologous and allogeneic HLA-A2+ targets with the anti-HLA-A2 mAb, BB7.2. These findings verify a similar lymphocyte/tumor interaction as has been documented in melanoma, suggesting a common mechanism of recognition of these human tumors by lymphocytes. C1 HARVARD UNIV,BRIGHAM & WOMENS HOSP,SCH MED,DEPT SURG,DIV SURG ONCOL,75 FRANCIS ST,BOSTON,MA 02115. USA,DEPT MED,STUDENT DETACHMENT,FT SAM HOUSTON,TX 78234. FU NCI NIH HHS [R01 CA45484, CA09535] NR 49 TC 67 Z9 67 U1 0 U2 0 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD NOV 15 PY 1993 VL 151 IS 10 BP 5481 EP 5491 PG 11 WC Immunology SC Immunology GA MF995 UT WOS:A1993MF99500038 PM 8228240 ER PT J AU BURGESS, EB AF BURGESS, EB TI TRUE STORIES OF THE ELITE FORCES - REAL-LIFE ACCOUNTS OF THE WORLDS CRACK MILITARY UNITS - LEWIS,JE SO LIBRARY JOURNAL LA English DT Book Review RP BURGESS, EB (reprint author), USA,TRALINET CTR,FT MONROE,VA 23561, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 SN 0363-0277 J9 LIBR J JI Libr. J. PD NOV 15 PY 1993 VL 118 IS 19 BP 88 EP 88 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA MG194 UT WOS:A1993MG19400136 ER PT J AU BHATT, AR KIM, KW STROSCIO, MA HIGMAN, JM AF BHATT, AR KIM, KW STROSCIO, MA HIGMAN, JM TI SIMPLIFIED MICROSCOPIC MODEL FOR ELECTRON OPTICAL-PHONON INTERACTIONS IN QUANTUM-WELLS SO PHYSICAL REVIEW B LA English DT Note ID ZINCBLENDE STRUCTURE COMPOUNDS; LATTICE-DYNAMICS; GAAS/ALAS SUPERLATTICES; FORCE-CONSTANTS; HETEROSTRUCTURES; GAAS; POLARIZABILITY; SCATTERING; SYSTEMS AB A simplified microscopic model of optical phonons in dimensionally confined structures is formulated and applied to calculate electron-optical-phonon scattering rates in GaAs/AlAs quantum wells. For this simplified model which circumvents performing a complicated ab initio calculation of the force constants at the interface, it is demonstrated that the resulting dispersion relation and scattering rates for electron-optical-phonon interactions agree very well with those obtained from detailed ab initio studies. It is also shown that for GaAs/A]As structures, the macroscopic dielectric continuum model provides a good approximation to the scattering rate predicted by the microscopic models. C1 USA,RES OFF,RES TRIANGLE PK,NC 27709. UNIV ILLINOIS,BECKMAN INST,URBANA,IL 61801. RP BHATT, AR (reprint author), N CAROLINA STATE UNIV,DEPT ELECT & COMP ENGN,RALEIGH,NC 27695, USA. NR 25 TC 14 Z9 14 U1 0 U2 0 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0163-1829 J9 PHYS REV B JI Phys. Rev. B PD NOV 15 PY 1993 VL 48 IS 19 BP 14671 EP 14674 DI 10.1103/PhysRevB.48.14671 PG 4 WC Physics, Condensed Matter SC Physics GA MJ065 UT WOS:A1993MJ06500080 ER PT J AU FOLKES, PA DUTTA, M RUDIN, S SHEN, H ZHOU, W SMITH, DD TAYSINGLARA, M NEWMAN, P COLE, M AF FOLKES, PA DUTTA, M RUDIN, S SHEN, H ZHOU, W SMITH, DD TAYSINGLARA, M NEWMAN, P COLE, M TI EXCITONIC RECOMBINATION OF DEGENERATE 2-DIMENSIONAL ELECTRONS WITH LOCALIZED PHOTOEXCITED HOLES IN A SINGLE-HETEROJUNCTION QUANTUM-WELL SO PHYSICAL REVIEW LETTERS LA English DT Article ID FERMI-EDGE SINGULARITIES; HIGH-PURITY GAAS; OPTICAL-SPECTRA; LUMINESCENCE SPECTRA; ABSORPTION-SPECTRA; FREE-CARRIER; PHOTOLUMINESCENCE; GAS; MAGNETOEXCITONS AB We report the observation of the excitonic recombination of degenerate quasi-two-dimensional electrons with localized photoexcited holes. Low-temperature photoluminescence and magnetophotoluminescence spectra exhibit a well resolved Mahan exciton resonance which is sensitive to electron density n(s). We observe a sharp decrease in the exciton oscillator strength and linewidth with the concomitant formation of biexcitons and a large discontinuity in the exciton ground-state energy at n(s) almost-equal-to 1.9 x 10(11) cm-2 . An abrupt transition from excitonic to free-electron-localized-hole recombination occurs at n(s) almost-equal-to 2.2 x 10(11) cm-2. RP FOLKES, PA (reprint author), USA,RES LAB,FT MONMOUTH,NJ 07703, USA. NR 30 TC 21 Z9 21 U1 0 U2 0 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0031-9007 J9 PHYS REV LETT JI Phys. Rev. Lett. PD NOV 15 PY 1993 VL 71 IS 20 BP 3379 EP 3382 DI 10.1103/PhysRevLett.71.3379 PG 4 WC Physics, Multidisciplinary SC Physics GA MG669 UT WOS:A1993MG66900037 ER PT J AU YOURICK, JJ DAWSON, JS BENTON, CD CRAIG, ME MITCHELTREE, LW AF YOURICK, JJ DAWSON, JS BENTON, CD CRAIG, ME MITCHELTREE, LW TI PATHOGENESIS OF 2,2'-DICHLORODIETHYL SULFIDE IN HAIRLESS GUINEA-PIGS SO TOXICOLOGY LA English DT Article DE ALKYLATING AGENTS; 2,2'-DICHLORODIETHYL SULFIDE; NAD(+); NADP(+); NIACINAMIDE; POLY(ADP-RIBOSE) POLYMERASE INHIBITOR; SULFUR MUSTARD; VESICATION ID SULFUR MUSTARD; NAD+ LEVELS; SKIN; NICOTINAMIDE; CULTURE; CELLS; MODEL AB Developing skin lesions on hairless guinea pigs due to 2,2'-dichlorodiethyl sulfide (sulfur mustard, HD) exposure were examined to determine the time course for the appearance of histopathologic markers in relationship to skin NAD+ and NADP(+) content after HD exposure. Hairless guinea pig skin was exposed to HD for 8 min by means of a vapor cup. Skin punches were taken at 1, 2, 4, 8, 12, 16, 20 and 24 h after HD exposure. Intracellular edema (IE) appeared at 2 h and increased steadily over 24 h. Epidermal necrosis (EN) and pustular epidermatitis (PE) developed at 8 h and reached a maximum at 16 h. Follicular necrosis (FN) appeared at 8 h and increased up to 24 h. Microvesicles (MV) developed between 12-16 h reaching a maximum at 24 h. Niacinamide (750 mg/kg, ip) pretreatment (30-min) reduced the incidence of MV (40%) and FN (45%) at 24 h, but did not reduce IE, EN, or PE. In all animals, skin NAD(+) content decreased to a minimum (20% of control) at 16 h, but NAD(+) decreases did not precede microvesicle formation. Skin NADP(+) content increased (260%) between 1-2 h and returned to control at 4 h. Skin cell NADP(+) increases may be indicative of an early phase of cellular oxidative stress that may contribute to HD-induced dermal pathogenesis. Since NAD(+) reductions did not precede microvesication and NAM-induced increases in NAD(+) content did not delay or reduce early cellular alterations, the contributory role of NAD(+) to microvesicle formation may be limited and other biochemical changes should be investigated. C1 USA,MED RES INST CHEM DEF,COMPARAT PATHOL BRANCH,ABERDEEN PROVING GROUND,MD 21010. RP YOURICK, JJ (reprint author), USA,MED RES INST CHEM DEF,APPL PHARMACOL BRANCH,ABERDEEN PROVING GROUND,MD 21010, USA. NR 18 TC 21 Z9 21 U1 0 U2 0 PU ELSEVIER SCI IRELAND LTD PI CLARE PA CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE, IRELAND SN 0300-483X J9 TOXICOLOGY JI Toxicology PD NOV 12 PY 1993 VL 84 IS 1-3 BP 185 EP 197 DI 10.1016/0300-483X(93)90116-A PG 13 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA ML259 UT WOS:A1993ML25900008 PM 8266337 ER PT J AU HOGE, CW SHLIM, DR ECHEVERRIA, P AF HOGE, CW SHLIM, DR ECHEVERRIA, P TI CYANOBACTERIUM-LIKE CYCLOSPORA SPECIES SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Letter C1 CANADIAN INT WATER & ENERGY CONSULTANTS CLIN,KATMANDU,NEPAL. RP HOGE, CW (reprint author), ARMED FORCES RES INST MED SCI,BANGKOK 10400,THAILAND. NR 3 TC 6 Z9 6 U1 0 U2 0 PU MASS MEDICAL SOC PI BOSTON PA 10 SHATTUCK, BOSTON, MA 02115 SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD NOV 11 PY 1993 VL 329 IS 20 BP 1504 EP 1504 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA MF292 UT WOS:A1993MF29200030 PM 8413470 ER PT J AU MAGILL, AJ GROGL, M GASSER, RA OSTER, CN AF MAGILL, AJ GROGL, M GASSER, RA OSTER, CN TI VISCERAL LEISHMANIASIS IN DESERT-STORM VETERANS - REPLY SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Letter C1 KEESLER AFB,BILOXI,MS 39534. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. RP MAGILL, AJ (reprint author), WALTER REED ARMY INST RES,WASHINGTON,DC 20307, USA. NR 5 TC 3 Z9 3 U1 0 U2 0 PU MASS MEDICAL SOC PI BOSTON PA 10 SHATTUCK, BOSTON, MA 02115 SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD NOV 11 PY 1993 VL 329 IS 20 BP 1504 EP 1504 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA MF292 UT WOS:A1993MF29200029 ER PT J AU CHENG, F YU, FTS GREGORY, DA AF CHENG, F YU, FTS GREGORY, DA TI MULTITARGET DETECTION USING SPATIAL SYNTHESIS JOINT TRANSFORM CORRELATION SO APPLIED OPTICS LA English DT Article AB A spatial synthesis method that improves accuracy of detection for joint transform multitarget recognition is discussed. The reference function used for the conventional joint transform correlation is replaced by a synthesized function for sharpening correlation profiles without the use of a filter in the Fourier domain. It is shown that the synthesized function can be truncated spatially to fit multiple-reference applications and that the effectiveness of this technique is not affected by the number of references. The implementation of the synthesized function, effects caused by noise disturbance, background cluttering, and spectral fringe binarization are investigated. C1 USA, MISSILE COMMAND, REDSTONE ARSENAL, AL 35898 USA. RP CHENG, F (reprint author), PENN STATE UNIV, DEPT ELECT & COMP ENGN, UNIV PK, PA 16802 USA. NR 6 TC 13 Z9 13 U1 0 U2 0 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD NOV 10 PY 1993 VL 32 IS 32 BP 6521 EP 6526 PG 6 WC Optics SC Optics GA MG301 UT WOS:A1993MG30100015 PM 20856493 ER PT J AU ROY, MJ DAMATO, JJ BURKE, DS AF ROY, MJ DAMATO, JJ BURKE, DS TI ABSENCE OF SEROCONVERSION OF HIV-1 ANTIBODY IN SEROREACTIVE INDIVIDUALS - REPLY SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Letter RP ROY, MJ (reprint author), WALTER REED ARMY MED CTR,WASHINGTON,DC 20307, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD NOV 10 PY 1993 VL 270 IS 18 BP 2179 EP 2179 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA ME816 UT WOS:A1993ME81600018 ER PT J AU KROENKE, K PRICE, RK AF KROENKE, K PRICE, RK TI SYMPTOMS IN THE COMMUNITY - PREVALENCE, CLASSIFICATION, AND PSYCHIATRIC COMORBIDITY SO ARCHIVES OF INTERNAL MEDICINE LA English DT Article ID PRIMARY CARE; FAMILIAL TRANSMISSION; COMMON SYMPTOMS; SOMATIZATION; DEPRESSION; DISORDERS; ILLNESS; THERAPY AB Background: While physical symptoms are the leading reason for outpatient visits, a substantial proportion of physical complaints and ''minor'' illnesses remain poorly understood. The purpose of our study was to determine the prevalence, patient-attributed cause, and psychiatric comorbidity of symptoms in a general population. Methods: We analyzed data on 13 538 individuals interviewed in the Epidemiologic Catchment Area Program, a multicommunity mental health survey that used the Diagnostic Interview Schedule to determine the prevalence of psychiatric disorders. The Diagnostic Interview Schedule inquires about 38 physical symptoms and includes a probing scheme to classify symptom seventy and potential cause. We focused on 26 symptoms most germane to primary care. Results: Of the 26 symptoms, 24 had been problems for more than 10% of persons at some point in their life, with the most common nonmenstrual symptoms being joint pains (36.7%), back pain (31.5%), headaches (24.9%), chest pain (24.6%), arm or leg pain (24.3%), abdominal pain (23.6%), fatigue (23.6%), and dizziness (23.2%). Most symptoms (84%) were at some point considered major in that they interfered with routine activities or had led individuals to take medications or visit a physician. Nearly one third of symptoms were either psychiatric or unexplained, and most symptoms were associated with at least a twofold increased lifetime risk of a common psychiatric disorder. Conclusions: Symptoms in the community are prevalent as well as bothersome. Often lacking an apparent physical explanation, such symptoms are associated with an increased likelihood of psychiatric disorders. C1 WALTER REED ARMY MED CTR,DEPT MED,WASHINGTON,DC 20307. WASHINGTON UNIV,SCH MED,DEPT PSYCHIAT,ST LOUIS,MO 63110. RP KROENKE, K (reprint author), UNIFORMED SERV UNIV HLTH SCI,DEPT MED,4301 JONES BRIDGE RD,BETHESDA,MD 20814, USA. FU NIDA NIH HHS [DA06163]; NIMH NIH HHS [MH17014, U01 MH 33870] NR 38 TC 392 Z9 398 U1 4 U2 19 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0003-9926 J9 ARCH INTERN MED JI Arch. Intern. Med. PD NOV 8 PY 1993 VL 153 IS 21 BP 2474 EP 2480 DI 10.1001/archinte.153.21.2474 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA ME659 UT WOS:A1993ME65900009 PM 8215752 ER PT J AU ARTHUR, RR ELSHARKAWY, MS COPE, SE BOTROS, BA OUN, S MORRILL, JC SHOPE, RE HIBBS, RG DARWISH, MA IMAM, IZE AF ARTHUR, RR ELSHARKAWY, MS COPE, SE BOTROS, BA OUN, S MORRILL, JC SHOPE, RE HIBBS, RG DARWISH, MA IMAM, IZE TI RECURRENCE OF RIFT-VALLEY FEVER IN EGYPT SO LANCET LA English DT Note AB Rift Valley fever (RVF) has been recorded in man and in domestic animals in Egypt after a 12-year absence. Human infections were first noted in the Aswan Governorate in late May, 1993. Only cases of ocular disease, an infrequent and late manifestation, were reported. Of 41 cases, 35 were tested serologically and 27 (77%) had RVF virus-specific IgM antibodies. An estimated 600-1500 infections occurred in the region. Abortions in cattle and buffalo were seen concurrently and antibodies to RVFV were present in 39% of domestic livestock, presumably unvaccinated. RVFV was isolated from an aborted water buffalo fetus. C1 JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,DEPT IMMUNOL & INFECT DIS,BALTIMORE,MD 21218. MINIST HLTH CAIRO,CAIRO,EGYPT. USA,INFECT DIS RES INST,FT DETRICK,MD. YALE UNIV,YALE ARBOVIRUS RES UNIT,NEW HAVEN,CT 06520. AIN SHAMS UNIV,FAC MED,CAIRO,EGYPT. RP ARTHUR, RR (reprint author), USN,MED RES UNIT 3,CODE 307,PSC 452,BOX 5000,FPO AE 09835 000,CAIRO,EGYPT. FU NIAID NIH HHS [AI 10984] NR 4 TC 63 Z9 65 U1 0 U2 3 PU LANCET LTD PI LONDON PA 42 BEDFORD SQUARE, LONDON, ENGLAND WC1B 3SL SN 0140-6736 J9 LANCET JI Lancet PD NOV 6 PY 1993 VL 342 IS 8880 BP 1149 EP 1150 DI 10.1016/0140-6736(93)92128-G PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA MF198 UT WOS:A1993MF19800014 PM 7901480 ER PT J AU OGWANG, R MWANGI, J GACHIHI, G NWACHUKWU, A ROBERTS, CR MARTIN, SK AF OGWANG, R MWANGI, J GACHIHI, G NWACHUKWU, A ROBERTS, CR MARTIN, SK TI USE OF PHARMACOLOGICAL AGENTS TO IMPLICATE A ROLE FOR PHOSPHOINOSITIDE HYDROLYSIS PRODUCTS IN MALARIA GAMETE FORMATION SO BIOCHEMICAL PHARMACOLOGY LA English DT Article ID INOSITOL TRISPHOSPHATE; SIGNAL TRANSDUCTION; PHOSPHODIESTERASE; CA-2+; DIACYLGLYCEROL; EXFLAGELLATION; PHOSPHATES; INHIBITION; SECRETION; PLATELETS AB The kinetics of phosphoinositol 4,5 bisphosphate hydrolysis products in activated Plasmodium falciparum gametocytes suggests a role for inositol trisphosphate [Ins(1,4,5)P3] and diacylglycerol (DAG) in the signal transduction pathway of malaria gametocytes. To investigate further this role, compounds that have an effect on the metabolism and biologic functions of these second messengers were tested in an in vitro system. Gentamycin, 2,3 diphosphoglycerate (2,3 DPG) and magnesium ion (Mg2+), inhibitors of Ins(1,4,5)P3 5' phosphatase, all stimulated gametocytes to exflagellate in suspended animation buffer, pH 7.4, at room temperature. In addition, methylxanthines, caffeine and theobromine, calcium ionophore (A-23187), and external calcium also stimulated exflagellation. In contrast, neomycin. an aminoglycoside that inhibits phospholipase C activity, and heparin, an antagonist of Ins(1,4,5)P3 binding to its receptor, inhibited microgamete formation. Quinine and chloroquine which can inhibit both phospholipase A and C activity also inhibited gametocyte exflagellation. The consistent manner in which these various compounds affect gametocyte activation further implicates phosphoinositol turnover in the signal transduction pathway of falciparum gametocytes. C1 KENYA GOVT MED RES CTR,CLIN RES CTR,NAIROBI,KENYA. UNIV NAIROBI,DEPT ZOOL,NAIROBI,KENYA. WALTER REED ARMY INST RES,USAMRU KENYA,WASHINGTON,DC 20307. NR 27 TC 25 Z9 25 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0006-2952 J9 BIOCHEM PHARMACOL JI Biochem. Pharmacol. PD NOV 2 PY 1993 VL 46 IS 9 BP 1601 EP 1606 DI 10.1016/0006-2952(93)90329-U PG 6 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA MG312 UT WOS:A1993MG31200012 PM 8240417 ER PT J AU CRAMER, CJ FAMINI, GR LOWREY, AH AF CRAMER, CJ FAMINI, GR LOWREY, AH TI USE OF CALCULATED QUANTUM-CHEMICAL PROPERTIES AS SURROGATES FOR SOLVATOCHROMIC PARAMETERS IN STRUCTURE-ACTIVITY-RELATIONSHIPS SO ACCOUNTS OF CHEMICAL RESEARCH LA English DT Review ID QUANTITATIVE STRUCTURE-ACTIVITY; SOLVATION ENERGY RELATIONSHIPS; LOCAL EMPIRICAL RULES; WATER PARTITION-COEFFICIENTS; SALMONELLA-TYPHIMURIUM TA100; THEORETICAL DESCRIPTORS; FUNDAMENTAL LAWS; PI-STAR; PHYSICOCHEMICAL PROPERTIES; SOLUBILITY PROPERTIES C1 UNIV MINNESOTA,INST SUPERCOMP,MINNEAPOLIS,MN 55455. USA,EDGEWOOD RES DEV & ENGN CTR,SCBRD,RT,ABERDEEN PROVING GROUND,MD 21010. USN,RES LAB,STRUCT & MATTER LAB,WASHINGTON,DC 20375. RP CRAMER, CJ (reprint author), UNIV MINNESOTA,DEPT CHEM,207 PLEASANT ST SE,MINNEAPOLIS,MN 55455, USA. RI Cramer, Christopher/B-6179-2011 OI Cramer, Christopher/0000-0001-5048-1859 NR 116 TC 72 Z9 73 U1 1 U2 7 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0001-4842 J9 ACCOUNTS CHEM RES JI Accounts Chem. Res. PD NOV PY 1993 VL 26 IS 11 BP 599 EP 605 DI 10.1021/ar00035a006 PG 7 WC Chemistry, Multidisciplinary SC Chemistry GA MH608 UT WOS:A1993MH60800006 ER PT J AU BUCKHEIT, RW GERMANYDECKER, J HOLLINGSHEAD, MG ALLEN, LB SHANNON, WM JANSSEN, PAJ CHIRIGOS, MA AF BUCKHEIT, RW GERMANYDECKER, J HOLLINGSHEAD, MG ALLEN, LB SHANNON, WM JANSSEN, PAJ CHIRIGOS, MA TI DIFFERENTIAL ANTIVIRAL ACTIVITY OF 2 TIBO DERIVATIVES AGAINST THE HUMAN IMMUNODEFICIENCY AND MURINE LEUKEMIA VIRUSES ALONE AND IN COMBINATION WITH OTHER ANTI-HIV AGENTS SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Article ID REVERSE-TRANSCRIPTASE INHIBITORS; DNA POLYMERASE-ALPHA; NONNUCLEOSIDE INHIBITORS; THYMIDINE 5'-TRIPHOSPHATE; ZIDOVUDINE AZT; 3'-AZIDO-3'-DEOXYTHYMIDINE; TYPE-1; REPLICATION; AIDS; INFECTIVITY AB R82913 and R86183, two derivatives of tetrahydroimidazo[4,5,1-jk][1,4]-benzodiazepin-2(1H)-thione (TIBO), were found to potently and selectively inhibit the replication and cell killing effects of a panel of biologically diverse laboratory and clinical strains of HIV-1. The two compounds exhibited significant activity in all human cell lines tested, as well as in fresh human peripheral blood lymphocytes and macrophages. One of these two compounds (R82913) was found to significantly inhibit the replication of a murine retrovirus (Rauscher murine leukemia virus) in both UV-XC plaque formation and virus yield reduction assays. R86183, despite differing from R82913 only in the positioning of a single chlorine molecule, was not active against the murine retrovirus but was 10-fold more potent in inhibiting HIV-1 replication. Combination antiviral assays with other reverse transcriptase inhibitors, including AZT, ddC, and carbovir, yielded synergistic anti-HIV activity with both TIBO derivatives. Additive to slightly synergistic results were obtained in combinations with ddI and phosphonoformic acid whereas additive to antagonistic activity was detected in combination with dextran sulfate. C1 SO RES INST,MICROBIOL RES DEPT,BIRMINGHAM,AL 35255. JANSSEN RES FDN,BEERSE,BELGIUM. USA,MED RES INST INFECT DIS,FREDERICK,MD 21702. RP BUCKHEIT, RW (reprint author), SO RES INST,FREDERICK RES CTR,DIV VIROL RES,431 AVIAT WAY,FREDERICK,MD 21701, USA. FU NIAID NIH HHS [5UO1-AI-25617] NR 45 TC 19 Z9 19 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD NOV PY 1993 VL 9 IS 11 BP 1097 EP 1106 DI 10.1089/aid.1993.9.1097 PG 10 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA MK130 UT WOS:A1993MK13000008 PM 7508723 ER PT J AU FAN, SX SKILLMAN, DR LIAO, MJ TESTA, D MELTZER, MS AF FAN, SX SKILLMAN, DR LIAO, MJ TESTA, D MELTZER, MS TI INCREASED EFFICACY OF HUMAN NATURAL INTERFERON-ALPHA (IFN-ALPHA-N3) VERSUS HUMAN RECOMBINANT IFN-ALPHA-2 FOR INHIBITION OF HIV-1 REPLICATION IN PRIMARY HUMAN MONOCYTES SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; NECROSIS-FACTOR-ALPHA; CONTROLLED TRIAL; IFN-ALPHA; INFECTION; EXPRESSION; MACROPHAGES; RECEPTOR; CELLS; AIDS AB Natural IFN-alpha n3, a purified mixture of many different natural IFN alpha species, was 10- to 100-fold more effective than equal concentrations of human rIFN-alpha 2b or rIFN-alpha 2a for inhibition of HIV replication in primary human monocytes. This difference was highly reproducible in multiple side-by-side experiments using the identical HIV-1 inoculum and the same monocyte target cells: natural IFN-alpha m3 was more effective than rIFN-alpha 2b at lower concentrations for protection against a constant HIV-1 inoculum; cells treated with natural IFN-alpha n3 were protected against a greater HIV-1 challenge than were cells treated with the same concentration of rIFN-alpha 2b. Fractionation of natural IFN-alpha n3 by reversed-phase high-pressure liquid chromatography (RP-HPLC) showed that most antiviral activity for HIV localized to discrete and reproducible peaks. The RP-NPLC peak that contained purified natural IFN-alpha 2b was the least effective fraction, These data suggest heterogeneity among IFN-alpha species for antiviral activity against HIV and may provide a molecular basis for more effective IFN-alpha therapy. C1 INTERFERON SCI INC,NEW BRUNSWICK,NJ 08901. WALTER REED ARMY INST RES,DEPT CELLULAR IMMUNOL,WASHINGTON,DC 20307. NR 36 TC 10 Z9 12 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD NOV PY 1993 VL 9 IS 11 BP 1115 EP 1122 DI 10.1089/aid.1993.9.1115 PG 8 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA MK130 UT WOS:A1993MK13000010 PM 8312053 ER PT J AU BIRX, DL LEWIS, MG VAHEY, M TENCER, K ZACK, PM BROWN, CR JAHRLING, PB TOSATO, G BURKE, D REDFIELD, R AF BIRX, DL LEWIS, MG VAHEY, M TENCER, K ZACK, PM BROWN, CR JAHRLING, PB TOSATO, G BURKE, D REDFIELD, R TI ASSOCIATION OF INTERLEUKIN-6 IN THE PATHOGENESIS OF ACUTELY FATAL SIV(SMM/PBJ-14) IN PIGTAILED MACAQUES SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; TUMOR NECROSIS FACTOR; LONG TERMINAL REPEATS; GENE-EXPRESSION; TRANSCRIPTION FACTOR; SOOTY MANGABEYS; GROWTH-FACTOR; FACTOR-ALPHA; T-CELLS; INFECTION AB Infection with a variant of simian immunodeficiency virus (SIVsmm/PBj-14) causes death in juvenile pigtailed macaques awithin 8 days of infection. The primary pathology is localized to the lymphoid tissues of the gut and spleen. Although the virus is present, the lesions are most consistent with acute reactive inflammation. We studied the serum and tissues for evidence of acute cytokine production often associated with acute inflammation. One factor, IL-6, was found to be significantly increased (>1000-fold) over all other measured cytokines in all the pigtailed macaques who died acutely. Increased levels of IL-6 were found both in the serum and in the inflamed tissues. mRNA for IL-6 was found in the tissues with the highest protein levels of IL-6. The marked increase in IL-6 and IL-6 mRNA correlated with the virus levels in the tissues and serum as determined by viral isolation, immunohistochemistry, and Northern blot analysis. These findings suggest that the underlying pathogenesis of primary tissue damage, necrosis, and death by PBj-14 is the induction of cytokine production. Although the presence of the virus may be critical for the initiation of these events, the intense inflammatory reaction is associated with the cause of death. C1 HENRY M JACKSON FDN ADVANCEMENT MIL MED,ROCKVILLE,MD 20850. WRAIR,DIV RETROVIROL,ROCKVILLE,MD 20850. USA,MED RES INST INFECT DIS,DEPT PATHOL,FREDERICK,MD 21702. USA,MED RES INST INFECT DIS,DIV DIS ASSESSMENT,FREDERICK,MD 21702. US FDA,CTR BIOL EVALUAT & RES,IMMUNOL LAB,BETHESDA,MD. RP BIRX, DL (reprint author), WALTER REED ARMY INST RES,DEPT RETROVIRAL RES,13 TAFT COURT,ROCKVILLE,MD 20850, USA. OI /0000-0002-5704-8094 FU NIAID NIH HHS [NIAID 1U01A125619-01] NR 34 TC 26 Z9 26 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD NOV PY 1993 VL 9 IS 11 BP 1123 EP 1129 DI 10.1089/aid.1993.9.1123 PG 7 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA MK130 UT WOS:A1993MK13000011 PM 8312054 ER PT J AU AGELL, G HOWIE, P KRAMER, E WILLIAMS, K WILSON, L AF AGELL, G HOWIE, P KRAMER, E WILLIAMS, K WILSON, L TI QUALITY IN ART-THERAPY - A PANEL HONORING ULMAN,ELINOR SO AMERICAN JOURNAL OF ART THERAPY LA English DT Article; Proceedings Paper CT 23RD ANNUAL CONF OF THE AMERICAN-ART-THERAPY-ASSOC CY NOV 04-08, 1992 CL LAS VEGAS, NV SP AMER ART THERAPY ASSOC C1 WALTER REED ARMY MED CTR,ACTIVITIES THERAPY SERV,WASHINGTON,DC 20307. GEORGE WASHINGTON UNIV,GRAD ART THERAPY PROGRAM,WASHINGTON,DC 20052. NYU,GRAD ART THERAPY PROGRAM,NEW YORK,NY 10003. RP AGELL, G (reprint author), NORWICH UNIV,VERMONT COLL,GRAD ART THERAPY PROGRAM,MONTPELIER,VT, USA. NR 14 TC 0 Z9 0 U1 0 U2 1 PU AMER J ART THERAPY PI MONTPELIER PA VERMONT COLL OF NORWICH UNIV, MONTPELIER, VT 05602 SN 0007-4764 J9 AM J ART THER JI Am. J. Art. Ther. PD NOV PY 1993 VL 32 IS 2 BP 34 EP 45 PG 12 WC Rehabilitation SC Rehabilitation GA MD570 UT WOS:A1993MD57000001 PM 10161013 ER PT J AU FINK, L BAUER, F PERRY, JJ AF FINK, L BAUER, F PERRY, JJ TI COINCIDENTAL POLYCYTHEMIA-VERA AND MULTIPLE-MYELOMA - CASE-REPORT AND REVIEW SO AMERICAN JOURNAL OF HEMATOLOGY LA English DT Note DE POLYCYTHEMIA VERA; MULTIPLE MYELOMA; ERYTHROID SUPPRESSION ID PLASMA-CELL MYELOMA; ACUTE-LEUKEMIA; THERAPY AB Polycythemia vera (PCV) and multiple myeloma are both clonal disorders of hematopoietic stem cells. The simultaneous occurrence of these diseases in an individual patient is rare. A case of synchronous PCV and smoldering myeloma is presented and the literature is reviewed. The issues of clinical importance in this unusual case include the mechanisms of anemia in multiple myeloma, the difficulty in using anemia as a parameter on which to base the initiation of therapy for myeloma, and the risks of treatment-induced leukemia and myelodysplasia. (C) 1993 Wiley-Liss, Inc.* C1 WAKE FOREST UNIV,BOWMAN GRAY SCH MED,CTR COMPREHENS CANC,WINSTON SALEM,NC 27103. UNIFORMED SERV UNIV HLTH SCI,DEPT MED,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,DEPT MED,HEMATOL ONCOL SERV,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT PATHOL & LAB MED,WASHINGTON,DC 20307. NR 31 TC 10 Z9 10 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0361-8609 J9 AM J HEMATOL JI Am. J. Hematol. PD NOV PY 1993 VL 44 IS 3 BP 196 EP 200 DI 10.1002/ajh.2830440311 PG 5 WC Hematology SC Hematology GA LZ664 UT WOS:A1993LZ66400010 PM 8213770 ER PT J AU SOLIMANDO, DA EDWARDS, MS LITER, ME AF SOLIMANDO, DA EDWARDS, MS LITER, ME TI COMMENTS ON STUDY OF ANTINEOPLASTIC DRUG HANDLERS SO AMERICAN JOURNAL OF HOSPITAL PHARMACY LA English DT Letter ID CYTO-TOXIC DRUGS; MUTAGENICITY; URINE; EXPOSURE; ASSAYS C1 WALTER REED ARMY MED CTR,PHARM SERV,WASHINGTON,DC 20307. VET AFFAIRS MED CTR,COOPER DR DIV,PHARM SERV,LEXINGTON,KY 40511. RP SOLIMANDO, DA (reprint author), WALTER REED ARMY MED CTR,ONCOL TREATMENT SECT,WASHINGTON,DC 20307, USA. NR 11 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC HEALTH-SYSTEM PHARMACISTS PI BETHESDA PA 7272 WISCONSIN AVE, BETHESDA, MD 20814 SN 0002-9289 J9 AM J HOSP PHARM JI Am. J. Hosp. Pharm. PD NOV PY 1993 VL 50 IS 11 BP 2311 EP 2312 PG 2 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA MF849 UT WOS:A1993MF84900011 PM 8266951 ER PT J AU COWAN, DN BRUNDAGE, JF POMERANTZ, RS WANN, ZF MILLER, RN AF COWAN, DN BRUNDAGE, JF POMERANTZ, RS WANN, ZF MILLER, RN TI RISK OF HIV-INFECTION AMONG ARMY RESERVE COMPONENTS PHYSICIANS SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Letter ID MEMBERS C1 WALTER REED ARMY INST RES,DIV PREVENT MED,WASHINGTON,DC 20307. RP COWAN, DN (reprint author), SRA TECHNOL INC,4700 KING ST,SUITE 300,ALEXANDRIA,VA 22302, USA. NR 5 TC 0 Z9 0 U1 0 U2 0 PU AMER PUBLIC HEALTH ASSOC INC PI WASHINGTON PA 1015 FIFTEENTH ST NW, WASHINGTON, DC 20005 SN 0090-0036 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD NOV PY 1993 VL 83 IS 11 BP 1640 EP 1641 DI 10.2105/AJPH.83.11.1640-a PG 2 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA MF808 UT WOS:A1993MF80800031 PM 8238698 ER PT J AU LOUBE, DI JOHNSON, JE WIENER, D ANDERS, GT BLANTON, HM HAYES, JA AF LOUBE, DI JOHNSON, JE WIENER, D ANDERS, GT BLANTON, HM HAYES, JA TI THE EFFECT OF FORCEPS SIZE ON THE ADEQUACY OF SPECIMENS OBTAINED BY TRANSBRONCHIAL BIOPSY SO AMERICAN REVIEW OF RESPIRATORY DISEASE LA English DT Note ID TRANS-BRONCHIAL BIOPSY; LUNG-BIOPSY AB This study prospectively compared the diagnostic yield of transbronchial biopsies using large and small forceps (cup sizes, 3 x 2 x 0.9 versus 2 x 1.5 x 0.6 mm, respectively). Diagnostic yield was compared by a pathologist, blinded to the size of forceps used on the basis of the relative amount of tissue obtained, alveolar tissue obtained, and ability to ascertain a histopathologic diagnosis. Large forceps obtained significantly more tissue than did small forceps (20 of 27 patients [74%] versus five of 27 patients [19%], p < 0.005, with similar amounts obtained in two patients). Also, large forceps obtained significantly more alveolar tissue than did small forceps (16 of 22 patients [73%] versus six of 22 patients [27%], p < 0.05, with no alveolar tissue obtained in five patients). In 18 of the 27 patients, biopsies performed resulted in nonspecific diagnoses, including fibrosis or chronic inflammation. All nine of the patients with a specific diagnosis were ultimately proved to have sarcoidosis. There was a trend toward more of these patients having noncaseating granulomas obtained with the large forceps than with the small forceps (seven of nine patients versus four of nine patients). No difference was observed in the amount of postbiopsy bleeding with either forceps. We conclude that large forceps used for transbronchial biopsy yield more tissue and more alveolar tissue than do small forceps. These findings may have an impact on the diagnostic yield in some diseases such as sarcoidosis. RP LOUBE, DI (reprint author), BROOKE ARMY MED CTR,DEPT MED,PULM DIS CRIT CARE SERV,FT SAM HOUSTON,TX 78234, USA. NR 8 TC 16 Z9 16 U1 0 U2 0 PU AMER LUNG ASSOC PI NEW YORK PA 1740 BROADWAY, NEW YORK, NY 10019 SN 0003-0805 J9 AM REV RESPIR DIS JI Am. Rev. Respir. Dis. PD NOV PY 1993 VL 148 IS 5 BP 1411 EP 1413 PG 3 WC Respiratory System SC Respiratory System GA NG374 UT WOS:A1993NG37400040 PM 8239184 ER PT J AU NICKELS, DA SABNIS, SG ANTONOVYCH, TT POTH, M AF NICKELS, DA SABNIS, SG ANTONOVYCH, TT POTH, M TI EFFECT OF CHRONIC GROWTH-HORMONE ADMINISTRATION ON DIABETIC NEPHROPATHY IN THE RAT SO ANNALS OF CLINICAL AND LABORATORY SCIENCE LA English DT Article ID INITIAL RENAL GROWTH; SOMATOSTATIN ANALOG; TRANSGENIC MICE; FACTOR-I; KIDNEY-FUNCTION; UNINEPHRECTOMIZED RATS; SOMATOMEDIN-C; HYPERTROPHY; SIZE; COMPLICATIONS AB Indirect data exist which implicate elevated growth hormone (GH) as a factor in the development of diabetic nephropathy. The administration of somatostatin (SRIH) has been shown to reverse many of the changes found in early diabetic nephropathy; however, it is unknown whether SRIH causes these effects by the suppression of GH or by other unspecified factors. To study directly the possible effect of excess GH in the development of diabetic nephropathy, either ovine growth hormone (0.2 mg oGH) or diluent buffer was administered IM daily for 19 weeks to diabetic rats and to controls. Severity of nephropathy was assessed by 24 hour urine albumin excretion (UAE), relative kidney weight, and kidney histology. Results showed that diabetic rats overall had elevated UAE and kidney weight vs non-diabetic rats (46.2 +/- 8.6 vs 5.4 +/- 1.3 mg per day and 5.7 +/- 0.2 vs 2.7 +/- 0.1 mg per g of body weight, respectively, p < 0.001). However, no differences were detected between diabetic rats treated with GH compared to control diabetic rats. Additionally, diabetic rats had histopathologic changes consistent with early diabetic nephropathy, but no difference in severity scores was found between diabetic groups. These data provide evidence against GH as an etiologic factor in the development of diabetic nephropathy and it is speculated by the authors that SRIH exerts its protective renal effects in diabetes by mechanisms other than GH suppression. C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. US ARMED FORCES,INST PATHOL,DEPT NEPHROPATHOL,WASHINGTON,DC. RP NICKELS, DA (reprint author), UNIFORMED SERV UNIV HLTH SCI,DEPT PEDIAT,4301 JONES BRIDGE RD,BETHESDA,MD 20814, USA. NR 29 TC 2 Z9 2 U1 0 U2 0 PU INST CLINICAL SCIENCE INC PI PHILADELPHIA PA 1833 DELANCEY PLACE, PHILADELPHIA, PA 19103 SN 0091-7370 J9 ANN CLIN LAB SCI JI Ann. Clin. Lab. Sci. PD NOV-DEC PY 1993 VL 23 IS 6 BP 462 EP 468 PG 7 WC Medical Laboratory Technology SC Medical Laboratory Technology GA MJ173 UT WOS:A1993MJ17300008 PM 8291901 ER PT J AU COHEN, AJ MOORE, P JONES, C MINER, TJ CARTER, WR ZURCHER, RP LUPKAS, R EDWARDS, FH AF COHEN, AJ MOORE, P JONES, C MINER, TJ CARTER, WR ZURCHER, RP LUPKAS, R EDWARDS, FH TI EFFECT OF INTERNAL MAMMARY HARVEST ON POSTOPERATIVE PAIN AND PULMONARY-FUNCTION SO ANNALS OF THORACIC SURGERY LA English DT Article ID MECHANICS; SURGERY; ARTERY AB Forty-three patients undergoing median sternotomy were evaluated for postoperative pain and pulmonary function. Group 1 (n = 26) had harvest of the internal mammary artery (IMA) and group 2 (n = 17) did not. Postoperative pain and pulmonary function were evaluated on the fifth postoperative day. Both groups showed a decrease in forced expiratory volume in 1 second (group 1, 44%; group 2, 39%), but there was no significant difference in the loss between the two groups (p = 0.32). Using a numeric rating scale, there was significant increase in postoperative pain in group 1 (group 1, 6.35; group 2, 3.82; p = 0.0002). There is a suggestion that internal mammary artery harvesting itself worsens postoperative pulmonary function tests, and this may be related to a significant increase in postoperative pain. C1 WALTER REED ARMY MED CTR,DEPT SURG,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT CARDIOVASC DIS,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT ANESTHESIA,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,DEPT SURG,BETHESDA,MD 20814. NR 9 TC 54 Z9 56 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0003-4975 J9 ANN THORAC SURG JI Ann. Thorac. Surg. PD NOV PY 1993 VL 56 IS 5 BP 1107 EP 1109 DI 10.1016/0003-4975(95)90025-X PG 3 WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery SC Cardiovascular System & Cardiology; Respiratory System; Surgery GA MF349 UT WOS:A1993MF34900020 PM 7902073 ER PT J AU CARRIERI, AH SCHMITT, CJ HERZINGER, CM JENSEN, JO AF CARRIERI, AH SCHMITT, CJ HERZINGER, CM JENSEN, JO TI COMPUTATION, VISUALIZATION, AND ANIMATION OF INFRARED MUELLER MATRIX-ELEMENTS BY SCATTERING FROM SURFACES THAT ARE ABSORBING AND RANDOMLY ROUGH SO APPLIED OPTICS LA English DT Article DE COMPUTER VISUALIZATION; MUELLER MATRIX; INFRARED SCATTERING; REMOTE DETECTION ID FULL-WAVE SOLUTIONS; DEPOLARIZATION AB Computation of Mueller matrix elements by infrared scattering from randomly rough two-dimensional surfaces and results of a method for graphic display of the data are presented. A full wave electromagnetic scattering model first generates raw data elements of the 4 x 4 Mueller matrix F(theta, n(lambda), k(lambda), sigma(s2), [h2]) in beam backscattering angle (theta) ranging from normal to oblique incidence, in refractive index of the beam scatterer (n(lambda) - ik(lambda) spanning the 9 less-than-or-equal-to lambda less-than-or-equal-to 12.5 mum midinfrared band, and in mean-squared slope (sigma(s2)) and mean-squared height ([h2]) of the scattering surface. These data are next compressed into a graphics format file occupying considerably less computer storage space and mapped into color images of the Mueller elements as viewed on a high-resolution graphics terminal. The diagonal and two off-diagonal elements are animated in the lambda-theta plane according to variations in sigma(s2) and [h2]. Predicted elements for polarized IR beam energies on vibrational resonance of the surface molecules, and particularly the off-diagonal elements, show subtle properties of the scatterer as viewed in the animation sequences. C1 TOWSON STATE UNIV, DEPT COMP & INFORMAT SCI, BALTIMORE, MD 21204 USA. UNIV NEBRASKA, LINCOLN, NE 68588 USA. RP CARRIERI, AH (reprint author), USA, EDGEWOOD RES DEV & ENGN CTR, ABERDEEN PROVING GROUND, MD 21010 USA. NR 11 TC 4 Z9 4 U1 0 U2 3 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 0003-6935 J9 APPL OPTICS JI Appl. Optics PD NOV 1 PY 1993 VL 32 IS 31 BP 6264 EP 6269 PG 6 WC Optics SC Optics GA MF623 UT WOS:A1993MF62300010 PM 20856460 ER PT J AU ROSEN, DL AF ROSEN, DL TI REMOTE BIODETECTION METHOD USING CIRCULAR-DICHROISM SO APPLIED SPECTROSCOPY LA English DT Article DE REMOTE SENSING, BIODETECTION; CIRCULAR DICHROISM; POLARIZATION; TRANSMISOMETRY; CHIRALITY; LIDAR ID POLARIZED LUMINESCENCE SPECTROSCOPY; LIDAR AB This paper proposes a new method for remote biodetection and simulates it with a laboratory optical table experiment. The new method, called circular polarization transmissometry, uses laser light scattered from the ground to measure the circular dichroism in an aerosol plume. In the optical table experiment, a scatter plate simulated the ground, and solutions of camphoroquinone simulated the biological aerosols. The experiment showed that this biodetection method could work even in daylight. Optical elements with inherent birefringence caused an optical artifact background that was subtracted from the signal. RP ROSEN, DL (reprint author), USA,RES LAB,AMSRL BE W,WHITE SANDS MISSILE RANGE,NM 88002, USA. NR 17 TC 1 Z9 1 U1 1 U2 1 PU SOC APPLIED SPECTROSCOPY PI FREDERICK PA PO BOX 1438, FREDERICK, MD 21701 SN 0003-7028 J9 APPL SPECTROSC JI Appl. Spectrosc. PD NOV PY 1993 VL 47 IS 11 BP 1887 EP 1891 DI 10.1366/0003702934066073 PG 5 WC Instruments & Instrumentation; Spectroscopy SC Instruments & Instrumentation; Spectroscopy GA MH157 UT WOS:A1993MH15700026 ER PT J AU SIMEONSSON, JB LEMIRE, GW SAUSA, RC AF SIMEONSSON, JB LEMIRE, GW SAUSA, RC TI TRACE DETECTION OF NITROCOMPOUNDS BY ARF LASER PHOTOFRAGMENTATION IONIZATION SPECTROMETRY SO APPLIED SPECTROSCOPY LA English DT Article DE PHOTOFRAGMENTATION SPECTROSCOPY; NO(X) DETECTION; RESONANCE-ENHANCED MULTIPHOTON IONIZATION (REMPI); ARF EXCIMER LASER ID INDUCED FRAGMENTATION; INDUCED FLUORESCENCE; CARBON-ATOMS; 193 NM; NITROMETHANE; SPECTROSCOPY; NO AB A new method for detecting trace vapors of NO2-containing compounds near atmospheric conditions has been demonstrated with the use of one-color-laser photofragmentation/ionization spectrometry. An ArF laser is employed to both photolytically fragment the target molecules in a collision-free environment and ionize the characteristic NO fragments. The production of NO is hypothesized to result from a combination of two NO2 unimolecular fragmentation pathways, one yielding NO in its X2PI electronic ground state and the other in its A2SIGMA+ excited state. Ionization of ground-state NO molecules is accomplished by resonance-enhanced multiphoton ionization processes via its A2SIGMA+ <-- X2PI (3, 0), B2PI <-- X2PI (7, 0) and/or D2SIGMA+ <-- X2PI (0, 1) bands at 193 nm. The analytical utility of this method is demonstrated in a molecular beam time-of-flight apparatus. Limits of detection range from the parts-per-million (ppm) to parts-per-billion (ppb) level for NO, NO2, CH3NO2, dimethylnitramine (DMNA), ortho- and meta-nitrotoluene, nitrobenzene, and trinitrotoluene (TNT). Under effusive beam experimental conditions, discrimination between structural isomers, ortho-nitrotoluene and meta-nitrotoluene, has been demonstrated with the use of their characteristic photofragmentation/ionization mass spectra. C1 USA,RES LAB,AMSRL WT PC,ABERDEEN PROVING GROUND,MD 21005. NR 27 TC 25 Z9 25 U1 4 U2 5 PU SOC APPLIED SPECTROSCOPY PI FREDERICK PA PO BOX 1438, FREDERICK, MD 21701 SN 0003-7028 J9 APPL SPECTROSC JI Appl. Spectrosc. PD NOV PY 1993 VL 47 IS 11 BP 1907 EP 1912 DI 10.1366/0003702934066190 PG 6 WC Instruments & Instrumentation; Spectroscopy SC Instruments & Instrumentation; Spectroscopy GA MH157 UT WOS:A1993MH15700029 ER PT J AU CIOFFI, WG BURLESON, DG PRUITT, BA AF CIOFFI, WG BURLESON, DG PRUITT, BA TI LEUKOCYTE RESPONSES TO INJURY SO ARCHIVES OF SURGERY LA English DT Article ID NEUTROPHIL LOCOMOTORY DYSFUNCTION; IMPAIRED IMMUNE-RESPONSE; SEVERELY BURNED PATIENTS; MEDIATED TISSUE-INJURY; GUINEA-PIG MODEL; THERMAL-INJURY; BLUNT TRAUMA; POLYMORPHONUCLEAR LEUKOCYTES; BACTERICIDAL DEFECT; COMPLEMENT PATHWAY AB Injury elicits a response from all cells of the immune system in which cytokines and other metabolic products of activated leukocytes can act either beneficially to provide for enhanced host resistance or deleteriously to depress the function of remote organs and cause what has been termed systemic inflammation. These at times antithecal responses of leukocytes that appear to integrate postinjury changes in the neuroendocrine, immune, and coagulation systems have been implicated as principal causative factors in multiple systems organ failure. Numerous investigators have evaluated a variety of therapeutic agents to prevent and control infection by restoring leukocyte function, while others have evaluated antagonists and monoclonal antibodies as a means of controlling the exaggerated and persistent actions of leukocytes and cytokines caused by systemic inflammation. The redundancies of the cell populations and the cytokines and other metabolites produced by the cells predictably limit the effectiveness of any single agent and make clinical evaluation of such agents difficult. RP CIOFFI, WG (reprint author), USA,INST SURG RES,FT SAM HOUSTON,TX 78234, USA. NR 78 TC 59 Z9 59 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0004-0010 J9 ARCH SURG-CHICAGO JI Arch. Surg. PD NOV PY 1993 VL 128 IS 11 BP 1260 EP 1267 PG 8 WC Surgery SC Surgery GA MG091 UT WOS:A1993MG09100013 PM 8239989 ER PT J AU SHIH, TM AF SHIH, TM TI COMPARISON OF SEVERAL OXIMES ON REACTIVATION OF SOMAN-INHIBITED BLOOD, BRAIN AND TISSUE CHOLINESTERASE ACTIVITY IN RATS SO ARCHIVES OF TOXICOLOGY LA English DT Article DE SOMAN; ORGANOPHOSPHORUS COMPOUNDS; NERVE AGENTS; CHOLINESTERASE; OXIMES; ENZYME REACTIVATION ID HI-6; ACETYLCHOLINESTERASE; EFFICACY; PROTECTION; INVIVO; 2-PAM; HS-6; METHYLPHOSPHONOFLUORIDATE; RECEPTORS; ATROPINE AB The ability of three oximes, HI-6, MMB-4 and ICD-467, to reactivate cholinesterase (ChE) inhibited by the organophosphorus compound soman was compared in blood (plasma and erythrocytes), brain regions (including spinal cord) and peripheral tissues of rats. Animals were intoxicated with soman (100 mug/kg, SC; equivalent to 0.9 x LD50 dose) and treated 1 min later with one of these oximes (100 or 200 mumol/kg, IM). Toxic sign scores and total tissue ChE activities were determined 30 min later. Soman markedly inhibited ChE activity in blood (93-96%), brain regions (ranging from 78% to 95%), and all peripheral tissues (ranging from 48.9% to 99.8%) except liver (11.9%). In blood, treatment with HI-6 or ICD-467 resulted in significant reactivation of soman-inhibited ChE. In contrast, MMB-4 was completely ineffective. HI-6 and ICD-467 were equally effective at the high dose. At the low dose ICD-467 treatment resulted in significantly higher plasma ChE than HI-6 treatment, whereas HI-6 treatment resulted in higher erythrocyte ChE than ICD-467 treatment. However, none of these three oximes reactivated or protected soman-inhibited ChE in the brain. In all peripheral tissues (except liver) studied, MMB-4 was not effective. HI-6 reactivated soman-inhibited ChE in all tissues except lung, heart, and skeletal muscle. ICD-467 was highly effective in reactivating ChE in all tissues and afforded a complete recovery of ChE to control levels in intercostal muscle and salivary gland. Oxime treatments did not modify the toxic scores produced by soman. However, treatment with the high dose (200 mumol/kg) of ICD467 depressed respiration and two of the six rats died in 10 min. These observations indicate that MMB-4 is completely ineffective in protecting and/or reactivating soman-inhibited ChE, HI-6 is an effective ChE reactivator as reported earlier in rats and other species, and the imidazolium oxime ICD-467 is a powerful reactivator of somaninhibited ChE; however, its toxic interactions with soman may not be related to tissue ChE levels. RP SHIH, TM (reprint author), USA,MED RES INST CHEM DEF,BIOCHEM PHARMACOL BRANCH,ATTN SGRD UV PB,ABERDEEN PROVING GROUND,MD 21010, USA. NR 54 TC 68 Z9 69 U1 0 U2 4 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0340-5761 J9 ARCH TOXICOL JI Arch. Toxicol. PD NOV PY 1993 VL 67 IS 9 BP 637 EP 646 DI 10.1007/BF01974071 PG 10 WC Toxicology SC Toxicology GA ME483 UT WOS:A1993ME48300007 PM 8311691 ER PT J AU MOLOFF, AL AF MOLOFF, AL TI DELAYED-ONSET ARTERIAL GAS EMBOLISM SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article ID CEREBRAL AIR-EMBOLISM; DECOMPRESSION-SICKNESS; PULMONARY BAROTRAUMA AB Numerous civilian and military personnel are involved in SCUBA diving activities. In this day of rapid air travel it is important that all physicians, not just those living near the coast or dive centers, be familiar with the basics of diagnosing and treating diving-related injuries. One of the more serious complications of dysbarism is Arterial Gas Embolism (AGE). This case history involves an atypical presentation of delayed onset AGE in a military diver trainee, and its treatment. This article then reviews the incidence, etiology, pathophysiology, ''classic'' presentation and current treatment of this disease. Systemic pathophysiology secondary to the effects of intravascular air of AGE is also discussed. RP MOLOFF, AL (reprint author), USA,SPECIAL OPERAT COMMAND,SURGEONS OFF,DIV MED OPERAT,3548 KELBURN DR,FAYETTEVILLE,NC 28311, USA. NR 12 TC 3 Z9 3 U1 0 U2 0 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD NOV PY 1993 VL 64 IS 11 BP 1040 EP 1043 PG 4 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA ME955 UT WOS:A1993ME95500010 PM 8280037 ER PT J AU MCCARROLL, JE URSANO, RJ VENTIS, WL FULLERTON, CS OATES, GL FRIEDMAN, H SHEAN, GD WRIGHT, KM AF MCCARROLL, JE URSANO, RJ VENTIS, WL FULLERTON, CS OATES, GL FRIEDMAN, H SHEAN, GD WRIGHT, KM TI ANTICIPATION OF HANDLING THE DEAD - EFFECTS OF GENDER AND EXPERIENCE SO BRITISH JOURNAL OF CLINICAL PSYCHOLOGY LA English DT Article ID STRESS AB In addition to the direct psychological effects of disaster stressors, anticipation of stress can itself be debilitating. We examined the relationship between the anticipated stress of handling the dead and gender and experience. Experienced persons had lower anticipated stress than inexperienced persons. Inexperienced females had higher anticipated stress than inexperienced males; experienced males and females did not differ. Results provide support for an 'inoculation' theory of stress buffering in disaster workers. C1 UNIFORMED SERV UNIV HLTH SCI,DEPT PSYCHIAT,BETHESDA,MD 20814. COLL WILLIAM & MARY,DEPT PSYCHOL,WILLIAMSBURG,VA 23185. UNIV MARYLAND,DEPT SOCIOL,COLL PK,MD 20742. RP MCCARROLL, JE (reprint author), WALTER REED ARMY INST RES,DEPT MIL PSYCHIAT,WASHINGTON,DC 20307, USA. NR 6 TC 13 Z9 13 U1 1 U2 1 PU BRITISH PSYCHOLOGICAL SOC PI LEICESTER PA ST ANDREWS HOUSE, 48 PRINCESS RD EAST, LEICESTER, LEICS, ENGLAND LE1 7DR SN 0144-6657 J9 BRIT J CLIN PSYCHOL JI Br. J. Clin. Psychol. PD NOV PY 1993 VL 32 BP 466 EP 468 PN 4 PG 3 WC Psychology, Clinical SC Psychology GA MJ192 UT WOS:A1993MJ19200009 PM 8298544 ER PT J AU CARDELLO, AV AF CARDELLO, AV TI NEW PRODUCT TRENDS - SENSE OR NONSENSE SO CEREAL FOODS WORLD LA English DT Editorial Material ID INTENSITY; QUALITY; COLOR RP CARDELLO, AV (reprint author), USA,NATICK RES DEV & ENGN CTR,NATICK,MA 01760, USA. NR 8 TC 4 Z9 4 U1 0 U2 1 PU AMER ASSOC CEREAL CHEMISTS PI ST PAUL PA 3340 PILOT KNOB RD, ST PAUL, MN 55121-2097 SN 0146-6283 J9 CEREAL FOOD WORLD JI Cereal Foods World PD NOV-DEC PY 1993 VL 38 IS 11 BP 870 EP 871 PG 2 WC Food Science & Technology SC Food Science & Technology GA MM520 UT WOS:A1993MM52000012 ER PT J AU KROENKE, K LAWRENCE, VA THEROUX, JF TULEY, MR HILSENBECK, S AF KROENKE, K LAWRENCE, VA THEROUX, JF TULEY, MR HILSENBECK, S TI POSTOPERATIVE COMPLICATIONS AFTER THORACIC AND MAJOR ABDOMINAL-SURGERY IN PATIENTS WITH AND WITHOUT OBSTRUCTIVE LUNG-DISEASE SO CHEST LA English DT Article ID PREOPERATIVE PULMONARY EVALUATION; SURGICAL PROCEDURES; RISK; SPIROMETRY; ANESTHESIA; PREDICTION AB Study objective: To determine the risk of thoracic and major abdominal surgery in patients with chronic obstructive pulmonary disease (COPD). Design: Retrospective cohort study with controls. Setting: A 692-bed teaching hospital. Patients: A cohort of 26 patients with severe COPD (FEV1 < 50 percent predicted) undergoing thoracic and major abdominal surgery was matched by age and type of operation to 52 patients with mild-moderate COPD and 52 patients with no COPD. Measurements and results: The 26 patients with severe COPD had rates of cardiac, vascular, and minor pulmonary complications similar to patients with mild-moderate COPD and without COPD, but experienced higher rates of serious pulmonary complications (23 percent vs 10 percent vs 4 percent, p = 0.03) and death (19 percent vs 4 percent vs 2 percent, p = 0.02). All deaths and instances of ventilatory failure in the patients with severe COPD occurred in the subset undergoing coronary artery bypass surgery. Logistic regression revealed that increased age, higher American Society of Anesthesiologists class, an abnormal chest radiograph, and perioperative bronchodilator administration were associated with higher cardiac or serious pulmonary complication rates. Spirometry was not an independent predictor of postoperative complications. Conclusions: Clinical variables appear better than preoperative spirometry in predicting postoperative cardiopulmonary complications. The utility of preoperative spirometry as well as the benefits of perioperative bronchodilators in patients in stable condition remain to be determined. C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. UNIV TEXAS,HLTH SCI CTR,SAN ANTONIO,TX 78284. AUDIE L MURPHY MEM VET ADM MED CTR,CTR GERIATR RES EDUC & CLIN,SAN ANTONIO,TX 78284. BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234. RP KROENKE, K (reprint author), UNIFORMED SERV UNIV HLTH SCI,DEPT MED,BETHESDA,MD 20814, USA. NR 38 TC 100 Z9 107 U1 0 U2 1 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 SN 0012-3692 J9 CHEST JI Chest PD NOV PY 1993 VL 104 IS 5 BP 1445 EP 1451 DI 10.1378/chest.104.5.1445 PG 7 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA MF615 UT WOS:A1993MF61500031 PM 8222804 ER PT J AU PARKER, MJM LANDRY, FJ PHILLIPS, YY AF PARKER, MJM LANDRY, FJ PHILLIPS, YY TI USE OF DO-NOT-RESUSCITATE ORDERS IN AN INTENSIVE-CARE SETTING SO CHEST LA English DT Article ID CRITICALLY ILL PATIENTS; CARDIOPULMONARY-RESUSCITATION; ETHICS; UNIT AB Study objectives: Do-not-resuscitate (DNR) orders have been espoused for the enhancement of patient autonomy, avoidance of futile medical intervention, and cost containment. Outcomes of cardiopulmonary resuscitation (CPR) in the intensive care setting have been dismal, with few patients surviving to discharge. This study compares patients who died in medical and surgical ICUs in a DNR status with those who died after attempted CPR. Design: Retrospective chart review of all patients who died in the medical and surgical ICU in a 2-year period. Measurements and results: A total of 195 cases were reviewed during the specified time period; 108 patients had undergone attempted resuscitation, and 87 patients died in a DNR status. There were no significant differences when preadmission disability, source of admission, location (medical ICU vs surgical ICU), chronic medical conditions, acute diagnosis, sex, and weight were considered. Patients who were designated ''DNR'' were significantly older than patients who underwent CPR (mean age, 65.7 years vs 58.9 years; p = 0.005). The DNR-designated patients were in general more severely ill as measured with the APACHE II system (mean score, 23.5 vs 20.7; p = 0.004), which was accounted for primarily by greater alterations in level of consciousness as measured with the Glascow Coma scale (mean score, 10.0 vs 12. 1; p = 0.001). Conclusions: Among patients dying in the medical and surgical ICUs in the authors' institution, only age and level of consciousness discriminated patients who died in a DNR status from those who died after attempted CPR. C1 WALTER REED ARMY MED CTR, DEPT PULM & CRIT CARE MED, WASHINGTON, DC 20307 USA. WALTER REED ARMY MED CTR, DEPT GEN INTERNAL MED, WASHINGTON, DC 20307 USA. NR 23 TC 15 Z9 15 U1 1 U2 1 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 USA SN 0012-3692 J9 CHEST JI Chest PD NOV PY 1993 VL 104 IS 5 BP 1592 EP 1596 PG 5 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA MF615 UT WOS:A1993MF61500057 ER PT J AU JONES, JC AF JONES, JC TI FORMAL THORACOTOMY WITH PULMONARY RESECTION SO CHEST LA English DT Letter RP JONES, JC (reprint author), WOMACK ARMY MED CTR,THORAC SURG SERV,FT BRAGG,NC, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 SN 0012-3692 J9 CHEST JI Chest PD NOV PY 1993 VL 104 IS 5 BP 1642 EP 1643 PG 2 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA MF615 UT WOS:A1993MF61500089 PM 8222859 ER PT J AU KRINITZSKY, EL AF KRINITZSKY, EL TI THE HAZARD IN USING PROBABILISTIC SEISMIC HAZARD ANALYSIS SO CIVIL ENGINEERING LA English DT Article RP KRINITZSKY, EL (reprint author), USA,CORPS ENGINEERS WATERWAYS EXPT STN,GEOTECH LAB,VICKSBURG,MS 39180, USA. NR 0 TC 2 Z9 2 U1 0 U2 1 PU ASCE-AMER SOC CIVIL ENGINEERS PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0885-7024 J9 CIVIL ENG JI Civil Eng. PD NOV PY 1993 VL 63 IS 11 BP 60 EP 61 PG 2 WC Engineering, Civil SC Engineering GA MF766 UT WOS:A1993MF76600018 ER PT J AU TAYLOR, AJ WORTHAM, DC BURGE, JR ROGAN, KM AF TAYLOR, AJ WORTHAM, DC BURGE, JR ROGAN, KM TI THE HEART IN POLYMYOSITIS - A PROSPECTIVE EVALUATION OF 26 PATIENTS SO CLINICAL CARDIOLOGY LA English DT Article DE CLINICAL STUDIES; POLYMYOSITIS; CARDIAC; ELECTROCARDIOGRAPHY; AMBULATORY MONITORING; ECHOCARDIOGRAPHY; RADIONUCLIDE VENTRICULOGRAPHY ID COMPUTER-ASSISTED ANALYSIS; AUTOPSIED PATIENTS; DERMATOMYOSITIS; ABNORMALITIES; ANTIBODIES; BLOCK AB Although cardiac abnormalities have been reported in patients with idiopathic polymyositis-dermatomyositis (PM), the nature and extent of these abnormalities have varied. The purpose of this study was to determine the prevalence and to obtain a better description of the spectrum of cardiac abnormalities in a cohort of patients with PM by use of a thorough noninvasive cardiac evaluation. Accordingly, we studied 26 patients with a history of PM and clinically inactive myositis (22 polymyositis, 4 dermatomyositis) between June 1984 and June 1991. Examination included history, physical examination, 12-lead electrocardiography, 24-h ambulatory electrocardiographic monitoring, chest radiography, transthoracic echocardiography, and radionuclide ventriculography. Of the patients studied, 77% were taking corticosteroid medications at a mean dose of 39 +/- 27 mg at the time of their evaluation. All 26 patients were identified as having two or more cardiac abnormalities. Cardiac symptoms and signs were common (62 and 81%, respectively), but were generally nonspecific. Electrocardiographic findings were most common (in 85% of cases), followed by findings on ambulatory monitoring (77%), echocardiography (42%), and radionuclide ventriculography (15%). The prevalence of mitral valve prolapse (8%) and hyperkinetic left ventricular contraction (12%) was significantly lower than previously reported. A secondary aim of this study was to determine associations between demographic variables including age, disease duration, cardiovascular symptoms, immunosuppressive therapy, autoantibody status, and creatinine phosphokinase level, and the presence of cardiac abnormalities. Of these patient variables, only increasing patient age was associated with an increased likelihood of cardiac abnormalities on noninvasive testing. In conclusion, abnormalities on noninvasive cardiac testing, many of which are minor and nonspecific, are prevalent in patients with PM. Our findings differ from previous reports in the demonstration of a low prevalence of mitral valve prolapse and hyperkinetic left ventricular contraction. In this population of patients with stable PM, only increased patient age was associated with a greater likelihood of abnormal cardiac findings. C1 WALTER REED ARMY MED CTR, CARDIOL SERV, WASHINGTON, DC 20307 USA. WALTER REED ARMY INST RES, DEPT BIOSTAT, WASHINGTON, DC 20307 USA. NR 25 TC 36 Z9 39 U1 2 U2 2 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0160-9289 EI 1932-8737 J9 CLIN CARDIOL JI Clin. Cardiol. PD NOV PY 1993 VL 16 IS 11 BP 802 EP 808 PG 7 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA ME712 UT WOS:A1993ME71200010 PM 8269658 ER PT J AU SFIKAKIS, PP MCCUNE, BK TSOKOS, M ARONI, K VAYIOPOULOS, G TSOKOS, GC AF SFIKAKIS, PP MCCUNE, BK TSOKOS, M ARONI, K VAYIOPOULOS, G TSOKOS, GC TI IMMUNOHISTOLOGICAL DEMONSTRATION OF TRANSFORMING GROWTH-FACTOR-BETA ISOFORMS IN THE SKIN OF PATIENTS WITH SYSTEMIC-SCLEROSIS SO CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY LA English DT Article ID SCLERODERMA FIBROBLASTS; INSITU HYBRIDIZATION; I PROCOLLAGEN; MESSENGER-RNA; COLLAGEN; FACTOR-BETA-1; LOCALIZATION; STIMULATION; EXPRESSION; PATHOGENESIS C1 WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20012. UNIV ATHENS,SCH MED,DEPT MED 1,ATHENS,GREECE. NCI,CHEMOPREVENT LAB,BETHESDA,MD 20892. NCI,PATHOL LAB,BETHESDA,MD 20892. RP SFIKAKIS, PP (reprint author), UNIFORMED SERV UNIV HLTH SCI,DEPT MED,4301 JONES BRIDGE RD,BETHESDA,MD 20814, USA. RI Aroni, Kyriaki/B-8331-2009 NR 30 TC 57 Z9 57 U1 0 U2 1 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0090-1229 J9 CLIN IMMUNOL IMMUNOP JI Clin. Immunol. Immunopathol. PD NOV PY 1993 VL 69 IS 2 BP 199 EP 204 DI 10.1006/clin.1993.1170 PG 6 WC Immunology; Pathology SC Immunology; Pathology GA MC285 UT WOS:A1993MC28500011 PM 8403557 ER PT J AU VLACHOS, DG SCHMIDT, LD ARIS, R AF VLACHOS, DG SCHMIDT, LD ARIS, R TI IGNITION AND EXTINCTION OF FLAMES NEAR SURFACES - COMBUSTION OF H-2 IN AIR SO COMBUSTION AND FLAME LA English DT Article ID STAGNATION-POINT FLOW; PREMIXED LAMINAR FLAMES; HOMOGENEOUS-HETEROGENEOUS COMBUSTION; BIFURCATION BEHAVIOR; LIMITS AB The ignition and extinction characteristics in homogeneous combustion of H-2 in air close to inert surfaces are studied with detailed chemistry involving 19 reversible reactions and 9 species. Flame structures for gases impinging on planar surfaces with stagnation point flow are computed using numerical bifurcation theory. Two-parameter bifurcation diagrams are constructed as functions of equivalence ratio and strain rate. It is shown that up to five multiple solutions can coexist for some conditions. When three steady states coexist, the species in abundance are HO2 and H2O2 at ignition and H, O, and OH at extinction. Isothermal walls, heated (constant power) walls, adiabatic walls, and symmetric counterflow jets are compared to examine the role of different stagnation surfaces on ignition and extinction for planar and axisymmetric flow. Implications of heterogeneous catalytic processes on ignition and extinction are also considered by examining surfaces that are sinks or sources for particular intermediate species. C1 UNIV MINNESOTA,DEPT CHEM ENGN & MAT SCI,MINNEAPOLIS,MN 55455. UNIV MINNESOTA,USA,HIGH PERFORMANCE COMP RES CTR,MINNEAPOLIS,MN 55455. OI Vlachos, Dionisios/0000-0002-6795-8403 NR 46 TC 66 Z9 67 U1 0 U2 3 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0010-2180 J9 COMBUST FLAME JI Combust. Flame PD NOV PY 1993 VL 95 IS 3 BP 313 EP 335 DI 10.1016/0010-2180(93)90135-P PG 23 WC Thermodynamics; Energy & Fuels; Engineering, Multidisciplinary; Engineering, Chemical; Engineering, Mechanical SC Thermodynamics; Energy & Fuels; Engineering GA MC675 UT WOS:A1993MC67500006 ER PT J AU DESCHAMPS, JR KOPECSMYTH, K POPPINO, JL FUTROVSKY, SL WARD, KB AF DESCHAMPS, JR KOPECSMYTH, K POPPINO, JL FUTROVSKY, SL WARD, KB TI COMPARISON OF ORGANOPHOSPHOROUS ACID ANHYDROLASES FROM DIFFERENT SPECIES USING MONOCLONAL-ANTIBODIES SO COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY LA English DT Article AB 1. Monoclonal antibodies were raised against squid hepatopancreas organophosphorous acid (OPA) anhydrolase (EC 3.1.8.2) and were used to study structural similarities with OPA anhydrolases isolated from different sources. 2. Common epitopes were identified in OPA anhydrolases with diverse origins, and with different substrate specificities. 3. Epitopes unique to the squid hepatopancreas OPA anhydrolase were identified; optic ganglion and hepatopancreas contain different enzymes which can be distinguished by their epitopes. C1 WALTER REED ARMY INST RES,DIV IMMUNOL,WASHINGTON,DC 20307. RP DESCHAMPS, JR (reprint author), USN,RES LAB,CODE 6030,WASHINGTON,DC 20375, USA. OI Deschamps, Jeffrey/0000-0001-5845-0010 NR 8 TC 5 Z9 5 U1 0 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0742-8413 J9 COMP BIOCHEM PHYS C JI Comp. Biochem. Physiol. C-Pharmacol. Toxicol. Endocrinol. PD NOV PY 1993 VL 106 IS 3 BP 765 EP 768 DI 10.1016/0742-8413(93)90240-L PG 4 WC Biochemistry & Molecular Biology; Endocrinology & Metabolism; Toxicology; Zoology SC Biochemistry & Molecular Biology; Endocrinology & Metabolism; Toxicology; Zoology GA MP732 UT WOS:A1993MP73200026 PM 7508356 ER PT J AU KRINITZSKY, EL AF KRINITZSKY, EL TI EARTHQUAKE PROBABILITY IN ENGINEERING .2. EARTHQUAKE RECURRENCE AND LIMITATIONS OF GUTENBERG-RICHTER B-VALUES FOR THE ENGINEERING OF CRITICAL STRUCTURES - THE THIRD JANS,RICHARD,H. DISTINGUISHED LECTURE IN ENGINEERING GEOLOGY SO ENGINEERING GEOLOGY LA English DT Review AB Gutenberg-Richter b-values are dysfunctional for site-specific applications in the engineering of critical structures. Their dysfunction results from differences in the mechanism of faulting and nonuniformity in the occurrences of earthquakes over time and space. The mechanisms of faulting include stick slip, various categories of controlled slip, and a multitude of thermodynamic slip processes which range from rock melting to stress releases by hydrothermal and other fluids at or near lithostatic pressures. These processes cause accelerated fault movements and chaotic earthquake occurrences, while asperities and barriers along faults contribute to temporary clustering effects that develop characteristic earthquakes but do not give them continuity through time. B-line projections must incorporate these complexities, but they can do so only when they are inclusive for large, seismically active areas such as southern California, the Aleutian are, etc. Within the relatively small earthquake source areas that determine damaging earthquake ground motions at individual engineering sites, b-values become dysfunctional at M greater than or equal to 5.0. Because b-values are the determinants of probabilistic seismic hazard analyses, there are severe restraints on the usefulness of probabilistic methods to assign earthquake ground motions for the engineering of critical structures. The latter include major darns, nuclear power plants, liquefied petroleum gas installations, repositories for dangerous wastes, military command centers, sensitive industrial and defense installations, fire stations, schools, and hospitals. RP KRINITZSKY, EL (reprint author), US CORPS ENGINEERS,WATERWAYS EXPT STN,GEOTECH LAB,VICKSBURG,MS 39180, USA. NR 0 TC 37 Z9 37 U1 0 U2 10 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0013-7952 J9 ENG GEOL JI Eng. Geol. PD NOV PY 1993 VL 36 IS 1-2 BP 1 EP 52 DI 10.1016/0013-7952(93)90017-7 PG 52 WC Engineering, Geological; Geosciences, Multidisciplinary SC Engineering; Geology GA MN183 UT WOS:A1993MN18300001 ER PT J AU JOHNSON, R AF JOHNSON, R TI MEDICAL ENTOMOLOGY RESEARCH IN KENYA SO ENTOMOLOGICAL NEWS LA English DT Article RP JOHNSON, R (reprint author), USA,PREVENT MED,FT LEWIS,WA, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ENTOMOL SOC PI PHILADELPHIA PA 1900 BENJ FRANKLIN PARKWAY, PHILADELPHIA, PA 19103-1195 SN 0013-872X J9 ENTOMOL NEWS JI Entomol. News PD NOV-DEC PY 1993 VL 104 IS 5 BP 234 EP & PG 0 WC Entomology SC Entomology GA MP405 UT WOS:A1993MP40500004 ER PT J AU BARRY, JW SKYLER, PJ TESKE, ME RAFFERTY, JA GRIM, BS AF BARRY, JW SKYLER, PJ TESKE, ME RAFFERTY, JA GRIM, BS TI PREDICTING AND MEASURING DRIFT OF BACILLUS-THURINGIENSIS SPRAYS SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article DE BACILLUS THURINGIENSIS; ENVIRONMENTAL FATE; FOREST SPRAYING; MODELS; SPRAY DRIFT ID MODEL AB Drift of the pesticide Bacillus thuringiensis Berliner var. kurstaki (Bt) was measured down-wind from a gypsy moth (Lymantria dispar L.) treatment block in mountain terrain. The study was conducted in conjunction with a project to eradicate the moth along the Wasatch mountain range of Utah. Objectives of the study were to quantitate drift, to evaluate drift sampling methods, and to compare FSCBG (Forest Service Cramer-Barry-Grim) computer model predictions to field measurements of Bt based on colony-forming units. The treatment block was sprayed by helicopter three times, within a 12-d period during June 1991, which provided a study of three replicates. During each spray, downslope drainage winds carried the spray over an array of samplers that extended 3,150 m downwind. The FSCBG dispersion model, exercised after the treatments, used meteorological inputs measured during the treatments to predict spray deposition and airborne dosage of Bt. Results of the study demonstrated a correlation among dosage, deposition and total flux samplers; a potential of Bt drift of at least 3,150 m; and FSCBG model predictions that generally followed the field recovery data. C1 CONTINUUM DYNAM INC,PRINCETON,NJ. USA,DUGWAY PROVING GROUND,UT. RP BARRY, JW (reprint author), US FOREST SERV,2121C 2ND ST,DAVIS,CA 95616, USA. NR 24 TC 12 Z9 13 U1 0 U2 2 PU SETAC PRESS PI PENSACOLA PA 1010 NORTH 12TH AVE, PENSACOLA, FL 32501-3370 SN 0730-7268 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD NOV PY 1993 VL 12 IS 11 BP 1977 EP 1989 DI 10.1897/1552-8618(1993)12[1977:PAMDOB]2.0.CO;2 PG 13 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA MB288 UT WOS:A1993MB28800004 ER PT J AU KADAKIA, SC AF KADAKIA, SC TI URINARY-INCONTINENCE ASSOCIATED WITH DYSPHAGIA SO GASTROINTESTINAL ENDOSCOPY LA English DT Letter RP KADAKIA, SC (reprint author), BROOKE ARMY MED CTR,DEPT MED,GASTROENTEROL SERV,SAN ANTONIO,TX, USA. NR 4 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0016-5107 J9 GASTROINTEST ENDOSC JI Gastrointest. Endosc. PD NOV-DEC PY 1993 VL 39 IS 6 BP 860 EP 861 PG 2 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA MJ964 UT WOS:A1993MJ96400039 PM 8293931 ER PT J AU MORAN, ML GREENFIELD, RJ AF MORAN, ML GREENFIELD, RJ TI RADAR SIGNATURE OF A 2.5-D TUNNEL SO GEOPHYSICS LA English DT Article ID BOREHOLE AB The effects of an infinitely long cylindrical void on short-pulse cross-borehole radar waveforms are modeled and analyzed. Pulsed electromagnetic sensing system (PEMSS) data are of particular interest. The PEMSS system developed by the Southwest Research Institute uses a vertically oriented electric dipole that emits a short electromagnetic pulse with peak power output centered around 30 MHz, which gives wavelengths of roughly 1.5 cavity diameters. The transmitter and receiver are typically located in boreholes separated by approximately 30 m. The model is based on field solutions for a vertically oriented point-source electric dipole. A three-dimensional (3-D) analytical frequency domain derivation of the Green's function is found using a spatial Fourier transform over the cylinder axis. The resulting wavenumber integral is evaluated by a numerical integration over wavenumber. Time-domain waveforms are produced by applying a Fourier transform to a 7-80 MHz band of frequencies in the Green's function spectrum. Model results agree well with PEMSS field data sets. Further modeling examines the effects on waveforms for a wide variety of cases in which the raypath is not orthogonal to the tunnel axis, including the effect of tunnel dip. An air-filled tunnel with a radius greater than 1.0 m produces a low amplitude shadow zone along its entire length. A low amplitude early arrival is observed in simulations with air-filled tunnels in which the source to receiver path forms an acute angle larger than 45 degrees with the tunnel axis. This arrival is interpreted as propagation through the tunnel. When this angle is smaller than 45 degree the tunnel is effectively an opaque object and only the energy diffracted around the cylindrical void is observed. Waveform behavior gradually transitions from propagation through the tunnel in the vicinity of 45 degrees. C1 PENN STATE UNIV,DEPT GEOSCI,UNIV PK,PA 16802. RP MORAN, ML (reprint author), COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 18 TC 12 Z9 12 U1 2 U2 2 PU SOC EXPLORATION GEOPHYSICISTS PI TULSA PA 8801 S YALE ST, TULSA, OK 74137 SN 0016-8033 J9 GEOPHYSICS JI Geophysics PD NOV PY 1993 VL 58 IS 11 BP 1573 EP 1587 DI 10.1190/1.1443373 PG 15 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA MG602 UT WOS:A1993MG60200003 ER PT J AU MAYER, AR CHAMBERS, SK GRAVES, E HOLM, C TSENG, PC NELSON, BE SCHWARTZ, PE AF MAYER, AR CHAMBERS, SK GRAVES, E HOLM, C TSENG, PC NELSON, BE SCHWARTZ, PE TI UNTITLED SO GYNECOLOGIC ONCOLOGY LA English DT Letter RP MAYER, AR (reprint author), WALTER REED ARMY MED CTR,DIV GYNECOL ONCOL,WASHINGTON,DC 20012, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0090-8258 J9 GYNECOL ONCOL JI Gynecol. Oncol. PD NOV PY 1993 VL 51 IS 2 BP 291 EP 292 PG 2 WC Oncology; Obstetrics & Gynecology SC Oncology; Obstetrics & Gynecology GA MQ993 UT WOS:A1993MQ99300036 ER PT J AU STRICKLAND, BR AUDEH, NF AF STRICKLAND, BR AUDEH, NF TI NUMERICAL-ANALYSIS TECHNIQUE FOR DIODE-LOADED DIPOLE ANTENNAS SO IEEE TRANSACTIONS ON ELECTROMAGNETIC COMPATIBILITY LA English DT Note AB A circuit model for a diode-loaded dipole electric field measurement probe is developed which is valid for frequencies below 10 GHz A nonnegligible dipole radius and the nonlinear characteristics of the diode are taken into consideration. The dipole lumped-circuit elements and diode capacitances are determined by theoretical means while the diode V-I characteristics and resistance are determined by a combined theoretical and empirical approach. Newton's iteration method is used to numerically solve the resulting nonlinear differential equation. Experimental measurements on a probe designed for operation between 1 and 1000 MHz and comparison with the theoretical results are presented. C1 UNIV ALABAMA,HUNTSVILLE,AL 35899. RP STRICKLAND, BR (reprint author), USA,STRATEG DEF COMMAND,HUNTSVILLE,AL 35807, USA. NR 8 TC 4 Z9 4 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9375 J9 IEEE T ELECTROMAGN C JI IEEE Trans. Electromagn. Compat. PD NOV PY 1993 VL 35 IS 4 BP 480 EP 484 DI 10.1109/15.247862 PG 5 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA ML177 UT WOS:A1993ML17700014 ER PT J AU PAMULAPATI, J SHEN, H WRABACK, M TAYSINGLARA, M DUTTA, M LUO, HC LU, Y AF PAMULAPATI, J SHEN, H WRABACK, M TAYSINGLARA, M DUTTA, M LUO, HC LU, Y TI NORMAL INCIDENCE GAAS/ALGAAS MULTIPLE-QUANTUM-WELL POLARIZATION MODULATOR USING AN INDUCED UNIAXIAL STRAIN SO IEEE TRANSACTIONS ON ELECTRON DEVICES LA English DT Meeting Abstract C1 USA,RES LAB,FT MONMOUTH,NJ 07703. NR 0 TC 3 Z9 3 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9383 J9 IEEE T ELECTRON DEV JI IEEE Trans. Electron Devices PD NOV PY 1993 VL 40 IS 11 BP 2144 EP 2145 DI 10.1109/16.239834 PG 2 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA ME783 UT WOS:A1993ME78300109 ER PT J AU LEUPOLD, HA AF LEUPOLD, HA TI APPROACHES TO PERMANENT-MAGNET CIRCUIT-DESIGN SO IEEE TRANSACTIONS ON MAGNETICS LA English DT Article; Proceedings Paper CT 1993 IEEE International Magnetics Conference (INTERMAG 93) CY APR 13-16, 1993 CL STOCKHOLM, SWEDEN SP IEEE, MAGNET SOC AB The advent of high-coercivity /high remanence magnet materials has greatly extended the range of applicability of permanent magnets so that many formerly impracticable devices are now viable. This paper discusses some of the more fruitful approaches to the use of these materials in magnetic circuit design and how application of comparatively few and simple techniques can result in a large number of useful devices. The approaches discussed are estimation of permeances, magnetic cladding, equivalent pole densities and current sheets, analytic application of Maxwell's equations, the magnetic moment rotation theorem and magnetic ''mirrors''. Some novel devices resulting from these applications are cited. RP LEUPOLD, HA (reprint author), USA,RES LAB,AMSRL EP EC H,FT MONMOUTH,NJ 07703, USA. NR 17 TC 19 Z9 22 U1 1 U2 5 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9464 J9 IEEE T MAGN JI IEEE Trans. Magn. PD NOV PY 1993 VL 29 IS 6 BP 2341 EP 2346 DI 10.1109/20.280860 PN 1 PG 6 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA MQ945 UT WOS:A1993MQ94500003 ER PT J AU LEUPOLD, HA TILAK, AS POTENZIANI, E AF LEUPOLD, HA TILAK, AS POTENZIANI, E TI ADJUSTABLE MULTI-TESLA PERMANENT-MAGNET FIELD SOURCES SO IEEE TRANSACTIONS ON MAGNETICS LA English DT Article; Proceedings Paper CT 1993 IEEE International Magnetics Conference (INTERMAG 93) CY APR 13-16, 1993 CL STOCKHOLM, SWEDEN SP IEEE, MAGNET SOC AB Permanent magnet flux sources of the enhanced ''magic'' ring / ''magic'' sphere types with an outer to inner radius ratio of 6 can be made to be mechanically field adjustable from 0.0 T to +/- 4.0 T in working gaps transverse to the applied field. In adjustable sources of similar size with gaps longitudinal to the field, the somewhat smaller field range of -3.0 to 3.4 T is attainable. The cylindrical sources pose no difficulties of access or adjustability and ways of providing these for the spheres as well are discussed. RP LEUPOLD, HA (reprint author), USA,AMSRL EP EC H,RES LAB,FT MONMOUTH,NJ 07703, USA. NR 3 TC 11 Z9 11 U1 1 U2 2 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9464 J9 IEEE T MAGN JI IEEE Trans. Magn. PD NOV PY 1993 VL 29 IS 6 BP 2902 EP 2904 DI 10.1109/20.281092 PN 1 PG 3 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA MQ945 UT WOS:A1993MQ94500174 ER PT J AU LEUPOLD, HA POTENZIANI, E TILAK, AS AF LEUPOLD, HA POTENZIANI, E TILAK, AS TI FLUX TAILORING OF PERMANENT-MAGNET SOLENOIDS SO IEEE TRANSACTIONS ON MAGNETICS LA English DT Article; Proceedings Paper CT 1993 IEEE International Magnetics Conference (INTERMAG 93) CY APR 13-16, 1993 CL STOCKHOLM, SWEDEN SP IEEE, MAGNET SOC AB Remedies for various deleterious effects on the fields of permanent magnet solenoids arising from practically necessary structural compromises are discussed and means of meeting some common mutually contradictory technical requirements are suggested. Among them are reduction of flux leakage by an order of magnitude, remedies for problems caused y access holes, provision of field-free regions within the magnetic structures for field sensitive components and elimination of unwanted partial shielding due to iron pole pieces. RP LEUPOLD, HA (reprint author), USA,AMSRL EP EC H,RES LAB,FT MONMOUTH,NJ 07703, USA. NR 4 TC 1 Z9 1 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9464 J9 IEEE T MAGN JI IEEE Trans. Magn. PD NOV PY 1993 VL 29 IS 6 BP 2905 EP 2907 DI 10.1109/20.281093 PN 1 PG 3 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA MQ945 UT WOS:A1993MQ94500175 ER PT J AU LEUPOLD, HA POTENZIANI, E AF LEUPOLD, HA POTENZIANI, E TI CHOICE OF MATERIAL IN THE DESIGN OF PERMANENT-MAGNET FLUX SOURCES SO IEEE TRANSACTIONS ON MAGNETICS LA English DT Article; Proceedings Paper CT 1993 IEEE International Magnetics Conference (INTERMAG 93) CY APR 13-16, 1993 CL STOCKHOLM, SWEDEN SP IEEE, MAGNET SOC AB To determine the temperature dependence of the magnetization of three commercial high energy product permanent magnet materials under conditions approximating those in a permanent magnet circuit, a method was devised whereby measurements were made at values of mu(L)=B/mu0H that remained constant as the temperature was varied. All the values of mu(L) used were on the same spherical sample for any given material. The values of mu(L) ranged from zero to ten thousand to mimic almost any circumstance likely to be encountered in most real permanent magnet circuits. The method of measurement is described and an example of the material selection procedure for an actual magnetic circuit is given. RP LEUPOLD, HA (reprint author), USA,RES LAB,AMSRL EP EC H,FT MONMOUTH,NJ 07703, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9464 J9 IEEE T MAGN JI IEEE Trans. Magn. PD NOV PY 1993 VL 29 IS 6 BP 3016 EP 3018 DI 10.1109/20.281105 PN 1 PG 3 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA MQ945 UT WOS:A1993MQ94500212 ER PT J AU CHANH, TC HEWETSON, JF AF CHANH, TC HEWETSON, JF TI POLYCLONAL ANTIIDIOTYPES INDUCE SPECIFIC ANTI-SAXITOXIN ANTIBODY-RESPONSES SO IMMUNOPHARMACOLOGY LA English DT Article DE SAXITOXIN; SODIUM CHANNEL BLOCKER; ANTIIDIOTYPE; VACCINE; PROTECTIVE IMMUNITY ID MONOCLONAL-ANTIBODIES; TETRODOTOXIN; PROTECTION; TOXICITY; VACCINE AB Polyclonal BALB/C mouse and New Zealand White rabbit anti-idiotypic antibodies were raised by immunization with a protein G-purified burro anti-saxitoxin IgG antibody preparation. Following absorption of non-anti-idiotype reactivity, murine and rabbit IgG were purified by protein A chromatography and used to immunize BALB/C mice for the induction of anti-saxitoxin antibody responses. Unconjugated BALB/C anti-idiotypes did not induce significant anti-saxitoxin reactivity in BALB/C mice, even after repeated immunizations. However, BALB/C mice immunized with purified BALB/C anti-idiotypes conjugated to keyhole limpet hemocyanin, or with purified, unconjugated rabbit anti-idiotypes, as aluminum hydroxide precipitates, induced significant and specific anti-saxitoxin immune responses. Saxitoxin, a sodium channel blocker, can protect cells treated with veratridine and ouabain, whose respective actions are to open sodium channels and to block the activity of Na/K-ATPase. The anti-idiotype-induced anti-saxitoxin antibodies inhibited saxitoxin from protecting against cell death induced by veratridine and ouabain treatment. These and other published experimental results strengthen the concept of anti-idiotype-based vaccines in eliciting protective immunity against a variety of low molecular weight, nonproteinaceous biological and chemical toxins, whose extreme toxicity does not allow their use as safe immunogens. C1 SW FDN BIOMED RES,CTR AIDS RES,SAN ANTONIO,TX 78228. USA,MED RES INST INFECT DIS,DEPT PATHOPHYSIOL,FREDERICK,MD 21701. RP CHANH, TC (reprint author), SW FDN BIOMED RES,DEPT VIROL & IMMUNOL,POB 28147,SAN ANTONIO,TX 78228, USA. NR 23 TC 5 Z9 6 U1 0 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0162-3109 J9 IMMUNOPHARMACOLOGY JI Immunopharmacology PD NOV-DEC PY 1993 VL 26 IS 3 BP 225 EP 233 DI 10.1016/0162-3109(93)90038-R PG 9 WC Immunology; Pharmacology & Pharmacy SC Immunology; Pharmacology & Pharmacy GA MF787 UT WOS:A1993MF78700005 PM 8288443 ER PT J AU VOGEL, PS HEIMER, WL SAU, P BENSON, PM AF VOGEL, PS HEIMER, WL SAU, P BENSON, PM TI PRIMARY CUTANEOUS NOCARDIA INFECTION DUE TO NOCARDIA-ASTEROIDES SO INTERNATIONAL JOURNAL OF DERMATOLOGY LA English DT Article C1 WALTER REED ARMY MED CTR,DERMATOL SERV,WASHINGTON,DC 20307. NR 5 TC 6 Z9 6 U1 0 U2 0 PU BLACKWELL SCIENCE LTD PI OXFORD PA OSNEY MEAD, OXFORD, OXON, ENGLAND OX2 0EL SN 0011-9059 J9 INT J DERMATOL JI Int. J. Dermatol. PD NOV PY 1993 VL 32 IS 11 BP 811 EP 812 DI 10.1111/j.1365-4362.1993.tb02769.x PG 2 WC Dermatology SC Dermatology GA ME610 UT WOS:A1993ME61000010 PM 8270339 ER PT J AU SKELTON, HG SMITH, KJ TURIANSKY, G COUZZO, D LINDSTROM, J WELCH, ML YEAGER, J WAGNER, KF AF SKELTON, HG SMITH, KJ TURIANSKY, G COUZZO, D LINDSTROM, J WELCH, ML YEAGER, J WAGNER, KF TI HELISTAT ABSORBABLE COLLAGEN HEMOSTATIC SPONGES IN CUTANEOUS SURGERY IN HIV-1+ PATIENTS SO INTERNATIONAL JOURNAL OF DERMATOLOGY LA English DT Article ID ACQUIRED-IMMUNODEFICIENCY-SYNDROME; AIDS-RELATED COMPLEX AB Background. While biopsies are often required for adequate diagnosis of skin lesions in HIV-1 infected patients, these procedures result in the possible exposure of medical personnel to blood and contaminated instruments. To reduce exposure of medical personnel to contaminated needles we have used collagen sponges instead of sutures to control bleeding from punch biopsy sites in HIV-1 infected patients. Methods. A collagen sponge was placed in all punch biopsy sites in HIV-1 infected patients. In cases where there was clinical evidence of local infection the sponges were removed 5-6 minutes after hemostasis was obtained.. Results. In over 500 biopsies in which Helistat collagen sponges were used, thera have been no cases of secondary infection, and there have been no delays in healing. Conclusions. We believe that the use of these sponges provides a high degree of safety for the physician, which may assure that the commonly atypical clinical lesions seen in HIV-1 disease are biopsied. In addition, these sponges provide hemostasis, particularly significant in this patient population, and convenience, without a significant risk of secondary infection, and may provide some benefit in healing. C1 WALTER REED ARMY MED CTR,DEPT DERMATOL,WASHINGTON,DC 20307. WALTER REED ARMY INST RES,WASHINGTON,DC 20307. WALTER REED ARMY INST RES,DEPT DERMATOL,WASHINGTON,DC 20307. HENRY M JACKSON FDN,BETHESDA,MD. RP SKELTON, HG (reprint author), ARMED FORCES INST PATHOL,DEPT DERMATOPATHOL,WASHINGTON,DC 20306, USA. NR 13 TC 6 Z9 6 U1 0 U2 0 PU BLACKWELL SCIENCE LTD PI OXFORD PA OSNEY MEAD, OXFORD, OXON, ENGLAND OX2 0EL SN 0011-9059 J9 INT J DERMATOL JI Int. J. Dermatol. PD NOV PY 1993 VL 32 IS 11 BP 835 EP 837 DI 10.1111/j.1365-4362.1993.tb02781.x PG 3 WC Dermatology SC Dermatology GA ME610 UT WOS:A1993ME61000022 PM 8270351 ER PT J AU CAI, L STEWART, WE SOHN, CW AF CAI, L STEWART, WE SOHN, CW TI TURBULENT BUOYANT FLOWS INTO A 2-DIMENSIONAL STORAGE TANK SO INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER LA English DT Article AB A numerical model was developed to simulate the turbulent mixing processes that occur when a cold fluid flows into a two dimensional tank containing a warmer fluid. The process simulates the charging of a chilled water thermal energy storage tank. The numerical model employs a transient stream function-vorticity formulation to predict the streamline and temperature distributions in the tank. The turbulent effect was modeled by a two equation turbulent model using the turbulent kinetic energy and turbulent length scale equations. The results for a lower corner inlet flow show that the cold fluid will not extensively mix with the warmer fluid in the tank for Archimedean number greater than five and inlet Reynolds number less than 1000. The warm and cold fluids will thermally stratify under these conditions and limitations. C1 USA,CORPS ENGINEERS,CONSTRUCT ENGN RES LAB,CHAMPAIGN,IL 61824. RP CAI, L (reprint author), UNIV MISSOURI,ENERGY RES LAB,TRUMAN CAMPUS,INDEPENDENCE,MO 64050, USA. NR 11 TC 22 Z9 22 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0017-9310 J9 INT J HEAT MASS TRAN JI Int. J. Heat Mass Transf. PD NOV PY 1993 VL 36 IS 17 BP 4247 EP 4256 DI 10.1016/0017-9310(93)90087-M PG 10 WC Thermodynamics; Engineering, Mechanical; Mechanics SC Thermodynamics; Engineering; Mechanics GA ME614 UT WOS:A1993ME61400019 ER PT J AU STAGGERS, N AF STAGGERS, N TI IMPACT OF SCREEN DENSITY ON CLINICAL NURSES COMPUTER TASK-PERFORMANCE AND SUBJECTIVE SCREEN SATISFACTION SO INTERNATIONAL JOURNAL OF MAN-MACHINE STUDIES LA English DT Article ID VISUAL-DISPLAY RP STAGGERS, N (reprint author), USA,DEF MED INFORMAT SYST,BLDG T60-A,WRAMC,WASHINGTON,DC 20307, USA. NR 29 TC 12 Z9 12 U1 0 U2 1 PU ACADEMIC PRESS LTD PI LONDON PA 24-28 OVAL RD, LONDON, ENGLAND NW1 7DX SN 0020-7373 J9 INT J MAN MACH STUD PD NOV PY 1993 VL 39 IS 5 BP 775 EP 792 DI 10.1006/imms.1993.1083 PG 18 WC Computer Science, Cybernetics; Ergonomics; Psychology SC Computer Science; Engineering; Psychology GA MK908 UT WOS:A1993MK90800004 ER PT J AU BIRX, DL BRUNDAGE, J LARSON, K ENGLER, R SMITH, L SQUIRE, E CARPENTER, G SULLIVAN, M RHOADS, J OSTER, C JAMES, W LUPTON, G WIERZBA, T BURKE, D REDFIELD, R AF BIRX, DL BRUNDAGE, J LARSON, K ENGLER, R SMITH, L SQUIRE, E CARPENTER, G SULLIVAN, M RHOADS, J OSTER, C JAMES, W LUPTON, G WIERZBA, T BURKE, D REDFIELD, R TI THE PROGNOSTIC UTILITY OF DELAYED-TYPE HYPERSENSITIVITY SKIN TESTING IN THE EVALUATION OF HIV-INFECTED PATIENTS SO JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY LA English DT Article DE DELAYED-TYPE HYPERSENSITIVITY SKIN TESTING; HIV DISEASE; ANERGY; PROGNOSIS ID CELL-MEDIATED-IMMUNITY; CUTANEOUS HYPERSENSITIVITY; STAGING CLASSIFICATION; POPULATION; MEN AB Many reagents and techniques have been used for delayed-type hypersensitivity (DTH) skin testing in the evaluation of HIV-infected patients, resulting in varied interpretation of the utility of DTH skin testing in this population. We report the development of a simple algorithm for selection of DTH antigens and the clinical relevance of DTH skin testing in HIV disease. Antigens and concentrations for testing were first evaluated in a demographically matched, HIV-negative, immunologically healthy population. The testing scheme was then applied to the HIV population of interest for 5 years at several clinical sites. The antigens and concentrations selected resulted in 100% reactivity to two or more antigens in the HIV-negative cohort. Anergy is thus a distinct immunologic abnormality. Although some correlation (r2 = 0.6) of skin test reactivity and CD4 cell count was found in a cohort of HIV-infected individuals, anergy was found to be independently predictive of the development of symptomatic late-stage disease (Walter Reed Stage 6), AIDS, or death. This stepwise evaluation of skin testing and reagents has led to the modification of the skin testing protocol by defining the minimum number of antigens required and establishing the independent prognostic role of DTH skin testing in the evaluation of HIV-infected patients. The addition of mumps (40 CFU/ml), tetanus (1:10), and candida (1:10) to the purified protein derivative (PPD) skin test provides the critical controls to evaluate the status of PPD skin test in HIV-infected individuals as well as to provide a useful and prognostic clinical immunology evaluation. C1 WALTER REED ARMY INST RES,DEPT PREVENT MED,WASHINGTON,DC 20307. SRA TECHNOL,ALEXANDRIA,VA. WRAMC,ALLERGY IMMUNOL SERV,WASHINGTON,DC. WRAMC,INFECT DIS SERV,WASHINGTON,DC. WRAMC,DERMATOL SERV,WASHINGTON,DC. ARMED FORCES INST PATHOL,DEPT DERMATOPATHOL,WASHINGTON,DC 20306. HENRY M JACKSON FDN ADVANCEMENT MIL MED,ROCKVILLE,MD. RP BIRX, DL (reprint author), WALTER REED ARMY INST RES,DEPT RETROVIRAL RES,DIV RETROVIROL,13 TAFT COURT,ROCKVILLE,MD 20850, USA. OI /0000-0002-5704-8094 NR 35 TC 64 Z9 64 U1 0 U2 1 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 1077-9450 J9 J ACQ IMMUN DEF SYND JI J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. PD NOV PY 1993 VL 6 IS 11 BP 1248 EP 1257 PG 10 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA MC830 UT WOS:A1993MC83000009 PM 7901383 ER PT J AU WOODBURN, KB GREEN, WR WESTERDAHL, HE AF WOODBURN, KB GREEN, WR WESTERDAHL, HE TI AQUATIC DISSIPATION OF TRICLOPYR IN LAKE SEMINOLE, GEORGIA SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY LA English DT Article ID VISION HERBICIDES; GARLON-3A; 3,5,6-TRICHLORO-2-PYRIDINOL; PERSISTENCE; RESPONSES; RATES; ESTER AB A field study was conducted to evaluate the environmental dissipation of triclopyr herbicide under aquatic-use conditions. Three 4-h plots in Lake Seminole, Georgia, were selected for use: one control, one aerial plot, and one subsurface plot; both applications were at the maximum aquatic-use rate of 2.5 mg/L. Water, sediment, plants, fish, clams, and crayfish were all analyzed for residues, and water temperature, oxygen levels, pH, and conductivity were monitored. The half-life for aqueous-phase triclopyr ranged from 0.5 to 3.6 days, and the dissipation in surface and bottom waters was equivalent. The intermediate decay product of triclopyr, 3,5,6-trichloro-2-pyridinol (TCP), had an observed aquatic half-life of less than 1 day. No accumulation of triclopyr or TCP on sediment was observed. The half-life of triclopyr metabolized by aquatic plants averaged 4 days. Fish species did not exhibit any bioconcentration of triclopyr or TCP, with only trace amounts of either compound found in fish tissue. Both clams and crayfish contained detectable residues of triclopyr. The elimination of triclopyr from clam tissue was more rapid, with an observed half-life of 1.5 days, vs 12 days for crayfish; retention of triclopyr in the crayfish carcass (carapace, chelopeds, and gills) may have been an important mechanism. There was no detectable decline in water quality in either treatment plot. C1 DOWELANCO,ENVIRONM CHEM LAB,MIDLAND,MI 48640. USA,ENGINEER WATERWAYS EXPT STN,ENVIRONM LAB,VICKSBURG,MS 39181. NR 19 TC 24 Z9 24 U1 1 U2 5 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0021-8561 J9 J AGR FOOD CHEM JI J. Agric. Food Chem. PD NOV PY 1993 VL 41 IS 11 BP 2172 EP 2177 DI 10.1021/jf00035a067 PG 6 WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science & Technology SC Agriculture; Chemistry; Food Science & Technology GA MH755 UT WOS:A1993MH75500067 ER PT J AU HUTSON, RA DUGGLEBY, CJ LOWE, JR MANCHEE, RJ TURNBULL, PCB AF HUTSON, RA DUGGLEBY, CJ LOWE, JR MANCHEE, RJ TURNBULL, PCB TI THE DEVELOPMENT AND ASSESSMENT OF DNA AND OLIGONUCLEOTIDE PROBES FOR THE SPECIFIC DETECTION OF BACILLUS-ANTHRACIS SO JOURNAL OF APPLIED BACTERIOLOGY LA English DT Article ID PROTECTIVE ANTIGEN GENE; DEPENDENT ADENYLATE-CYCLASE; LETHAL FACTOR GENE; HYBRIDIZATION ASSAY; NUCLEOTIDE-SEQUENCE; MOLECULAR-CLONING; ESCHERICHIA-COLI; LABELED PROBES; EXPRESSION; ENCAPSULATION AB Two DNA probes and a number of oligonucleotide probes were designed from the virulence factor genes of Bacillus anthracis. These probes were tested for specificity against 52 B. anthracis strains and 233 Bacillus strains encompassing 23 other species. A rapid slot blotting technique was used for screening the large numbers of isolates involved. All probes tested appeared to be specific for B. anthracis under high stringency conditions. These probes could differentiate between virulent and avirulent strains. The probes were also applied to the detection of B. anthracis in routine environmental and clinical samples. A non-radioactive hybridization and detection system based on digoxigenin-11-dUTP was developed. C1 PUBL HLTH LAB SERV,CTR APPL MICROBIOL & RES,DIV BIOL,SALISBURY,WILTS,ENGLAND. PUBL HLTH LAB SERV,CTR APPL MICROBIOL & RES,DIV BIOTECHNOL,SALISBURY,WILTS,ENGLAND. CHEM & BIOL DEF ESTAB,DIV DEF MICROBIOL,SALISBURY,WILTS,ENGLAND. USA,MED RES INST INFECT DIS,FREDERICK,MD. NR 35 TC 18 Z9 19 U1 0 U2 1 PU BLACKWELL SCIENCE LTD PI OXFORD PA OSNEY MEAD, OXFORD, OXON, ENGLAND OX2 0EL SN 0021-8847 J9 J APPL BACTERIOL JI J. Appl. Bacteriol. PD NOV PY 1993 VL 75 IS 5 BP 463 EP 472 DI 10.1111/j.1365-2672.1993.tb02803.x PG 10 WC Biotechnology & Applied Microbiology; Microbiology SC Biotechnology & Applied Microbiology; Microbiology GA MH225 UT WOS:A1993MH22500010 PM 8300447 ER PT J AU GRAFT, R FISCHER, T GRAY, A KENNERLY, S AF GRAFT, R FISCHER, T GRAY, A KENNERLY, S TI ILLUMINATION-DEPENDENT DYNAMIC RESISTANCE OF HG1-XCDXTE HETEROJUNCTION PHOTODIODES SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID HGCDTE HETEROJUNCTIONS; BARRIERS AB Experimental data are presented on the illumination dependence of the dynamic resistance of long-wave infrared heterojunction photodiodes and the results are interpreted using a numerical drift/diffusion device model. The diodes are double-layer heterojunctions grown by liquid-phase epitaxy; nominal cutoff wavelength, zero-bias quantum efficiency, and resistance area product are 10.6 mum, 76%, and 210 OMEGA cm2 (77 K), respectively. It is shown that for a single-sided p-on-n heterojunction, the illumination dependence is due to an increase in hole current resulting from a voltage-dependent increase in the base layer diffusion current. Calculated results are provided as a function of relative hetero- and p-n junction location and applied reverse bias. The results are compared with experimental data obtained on back-illuminated HgCdTe heterojunction #diodes. An interpretation based upon the voltage dependence of the hole concentration at the depletion edge is presented and contrasted with recent models appearing in the literature. RP GRAFT, R (reprint author), USA,RES LAB,FT BELVOIR,VA 22060, USA. NR 11 TC 11 Z9 11 U1 0 U2 1 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD NOV 1 PY 1993 VL 74 IS 9 BP 5705 EP 5712 DI 10.1063/1.354186 PG 8 WC Physics, Applied SC Physics GA MG597 UT WOS:A1993MG59700063 ER PT J AU ROTHENBERG, ML KUHN, JG BURRIS, HA NELSON, J ECKARDT, JR TRISTANMORALES, M HILSENBECK, SG WEISS, GR SMITH, LS RODRIGUEZ, GI ROCK, MK VONHOFF, DD AF ROTHENBERG, ML KUHN, JG BURRIS, HA NELSON, J ECKARDT, JR TRISTANMORALES, M HILSENBECK, SG WEISS, GR SMITH, LS RODRIGUEZ, GI ROCK, MK VONHOFF, DD TI PHASE-I AND PHARMACOKINETIC TRIAL OF WEEKLY CPT-11 SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Article ID DNA TOPOISOMERASE-I; CAMPTOTHECIN ANALOG CPT-11; CELL LUNG-CANCER; BIOLOGICAL-ACTIVITY; ANTITUMOR-ACTIVITY; NUDE-MICE; XENOGRAFTS; NSC-100880; INHIBITION C1 GH BESSELAAR ASSOS,PRINCETON,NJ. CANC THERAPY & RES CTR S TEXAS,SAN ANTONIO,TX. BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234. RP ROTHENBERG, ML (reprint author), UNIV TEXAS,HLTH SCI CTR,DIV ONCOL,7703 FLOYD CURL DR,SAN ANTONIO,TX 78284, USA. NR 32 TC 262 Z9 264 U1 1 U2 3 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0732-183X J9 J CLIN ONCOL JI J. Clin. Oncol. PD NOV PY 1993 VL 11 IS 11 BP 2194 EP 2204 PG 11 WC Oncology SC Oncology GA ME932 UT WOS:A1993ME93200019 PM 8229134 ER PT J AU DONNELLY, JC AF DONNELLY, JC TI A SIMPLIFIED MODEL TO DEMONSTRATE THE OPERATION OF ELECTRONIC ROOT-CANAL MEASURING DEVICES SO JOURNAL OF ENDODONTICS LA English DT Article AB This article describes how to construct and use a simplified model to demonstrate the operation of electronic root canal measuring devices. The model is effective, more economical than those previously described, and uses readily available materials. C1 USA,DENT ACT,FT HOOD,TX. NR 2 TC 15 Z9 18 U1 1 U2 1 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0099-2399 J9 J ENDODONT JI J. Endod. PD NOV PY 1993 VL 19 IS 11 BP 579 EP 580 DI 10.1016/S0099-2399(06)81292-6 PG 2 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA ME543 UT WOS:A1993ME54300011 PM 8151250 ER PT J AU CERCO, CF COLE, T AF CERCO, CF COLE, T TI 3-DIMENSIONAL EUTROPHICATION MODEL OF CHESAPEAKE BAY SO JOURNAL OF ENVIRONMENTAL ENGINEERING-ASCE LA English DT Article AB CE-QUAL-ICM is a three-dimensional,time-variable,eutrophication model. CE-QUAL-ICM incorporates 22 state variables that include physical properties multiple forms of algae, carbon, nitrogen, phosphorus, and silica; and dissolved oxygen. The model is part of a larger package that includes a three-dimensional hydrodynamic model and a benthic-sediment diagenesis model. Application to Chesapeake Bay over a three-year period, 1984-86, indicates the model successfully simulates water-column and sediment processes that affect water quality. Phenomena simulated include formation of the spring algal bloom subsequent to the annual peak in nutrient runoff, onset and breakup of summer anoxia, and coupling of organic particle deposition with sediment-water nutrient and oxygen fluxes. The study demonstrates that complex eutrophication problems can be addressed with coupled three-dimensional hydrodynamic and water-quality models. RP CERCO, CF (reprint author), USACE,WATERWAYS EXPT STN,MAIL STOP ES-Q,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 13 TC 177 Z9 180 U1 2 U2 33 PU ASCE-AMER SOC CIVIL ENGINEERS PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-9372 J9 J ENVIRON ENG-ASCE JI J. Environ. Eng.-ASCE PD NOV-DEC PY 1993 VL 119 IS 6 BP 1006 EP 1025 DI 10.1061/(ASCE)0733-9372(1993)119:6(1006) PG 20 WC Engineering, Environmental; Engineering, Civil; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA MH786 UT WOS:A1993MH78600003 ER PT J AU SORIAL, GA SUIDAN, MT VIDIC, RD MALONEY, SW AF SORIAL, GA SUIDAN, MT VIDIC, RD MALONEY, SW TI COMPETITIVE ADSORPTION OF PHENOLS ON GAC .1. ADSORPTION EQUILIBRIUM SO JOURNAL OF ENVIRONMENTAL ENGINEERING-ASCE LA English DT Article ID DILUTE AQUEOUS-SOLUTIONS; ACTIVATED CARBON; ORGANIC SOLUTES; THERMODYNAMICS; CAPACITY; DESIGN; OXYGEN; MODEL AB The impact of the presence of molecular oxygen on multicomponent adsorption is evaluated in this study. Adsorption equilibria for binary mixtures of phenol/o-cresol and ternary mixtures of phenol/o-cresol/3-ethylphenol on granular activated carbon (GAC) are determined at 23-degrees-C using three different initial-concentration combinations. Experiments were conducted under conditions where molecular oxygen is present (oxic adsorption) and under conditions where oxygen was excluded from the adsorbate solution and the GAC particles (anoxic adsorption). The ideal adsorbed solution theory, using the Myers equation for correlating the single-solute anoxic isotherms, is found to accurately describe the competitive adsorption behavior of these phenolic mixtures under anoxic conditions. When the Freundlich equation was used to describe the single solute behavior, increased deviations were observed. Poor model predictions for the oxic isotherms arc attributed to the presence of molecular oxygen, which promotes the polymerization of the adsorbates on the surface of GAC. C1 USA,CONSTR ENGN RES LAB,CHAMPAIGN,IL 61826. RP SORIAL, GA (reprint author), UNIV CINCINNATI,DEPT CIVIL & ENVIRONM ENGN,CINCINNATI,OH 45221, USA. NR 23 TC 29 Z9 29 U1 0 U2 5 PU ASCE-AMER SOC CIVIL ENGINEERS PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-9372 J9 J ENVIRON ENG-ASCE JI J. Environ. Eng.-ASCE PD NOV-DEC PY 1993 VL 119 IS 6 BP 1026 EP 1043 DI 10.1061/(ASCE)0733-9372(1993)119:6(1026) PG 18 WC Engineering, Environmental; Engineering, Civil; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA MH786 UT WOS:A1993MH78600004 ER PT J AU SORIAL, GA SUIDAN, MT VIDIC, RD MALONEY, SW AF SORIAL, GA SUIDAN, MT VIDIC, RD MALONEY, SW TI COMPETITIVE ADSORPTION OF PHENOLS ON GAC .2. ADSORPTION DYNAMICS UNDER ANOXIC CONDITIONS SO JOURNAL OF ENVIRONMENTAL ENGINEERING-ASCE LA English DT Article ID MULTI-SOLUTE ADSORPTION; 2 DISSOLVED ORGANICS; ACTIVATED CARBON; MASS-TRANSFER; PARAMETER EVALUATION; KINETICS; SYSTEMS; BATCH; THERMODYNAMICS; ADSORBERS AB The impact of the presence of molecular oxygen in the test environment is further evaluated for adsorption behavior of a mixture of phenolic compounds on fixed-bed GAC adsorbers. Adsorption breakthrough curves are obtained for the single-solute system phenol, o-cresol, and 3-ethylphenol; the binary solute system of phenol and o-cresol; and the ternary solute system of phenol, o-cresol, and 3-ethylphenol. The plug-flow homogeneous surface diffusion model is evaluated as a predictor of adsorber performance for these systems. The binary and ternary solute calculations of the model are performed using kinetic parameters determined for the single-solute system. The ideal adsorbed solution theory is used to describe the equilibrium on the surface of the adsorbent particle. The model predictions for the single-solute system agree very well with the experimental breakthrough curves conducted under anoxic conditions, with exceptions to the later portion of the o-cresol breakthrough, where tailing of the experimental breakthrough has been noticed due to the presence of limited concentrations of dissolved oxygen in the feed. The model predictions for the binary and ternary solute systems agree well with the experimental data collected under anoxic conditions. C1 USA,CONSTR ENGN RES LAB,CHAMPAIGN,IL 61826. RP SORIAL, GA (reprint author), UNIV CINCINNATI,DEPT CIVIL & ENVIRONM ENGN,CINCINNATI,OH 45221, USA. NR 30 TC 10 Z9 10 U1 0 U2 2 PU ASCE-AMER SOC CIVIL ENGINEERS PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-9372 J9 J ENVIRON ENG-ASCE JI J. Environ. Eng.-ASCE PD NOV-DEC PY 1993 VL 119 IS 6 BP 1044 EP 1058 DI 10.1061/(ASCE)0733-9372(1993)119:6(1044) PG 15 WC Engineering, Environmental; Engineering, Civil; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA MH786 UT WOS:A1993MH78600005 ER PT J AU KAIN, KC ORLANDI, PA HAYNES, JD SIM, BKL LANAR, DE AF KAIN, KC ORLANDI, PA HAYNES, JD SIM, BKL LANAR, DE TI EVIDENCE FOR 2-STAGE BINDING BY THE 175-KD ERYTHROCYTE BINDING ANTIGEN OF PLASMODIUM-FALCIPARUM SO JOURNAL OF EXPERIMENTAL MEDICINE LA English DT Article ID MALARIA PARASITES; MEROZOITE INVASION; RECEPTOR; KNOWLESI; SURFACE; IDENTIFICATION; ANTIBODIES; SCHIZONTS; VACCINES; PROTEINS AB Plasmodium falciparum malaria merozoites invade human erythrocytes bearing sialic acid in a multistage process involving the sialic acid-dependent binding of a malaria molecule, the 175-kD erythrocyte binding antigen (EBA-175). We show here that after the initial interaction of EBA-175 with its sialic acid-containing erythrocyte determinant, endogenous proteases can cleave EBA-175 to 65-kD fragment(s), whose binding to erythrocytes is sialic acid independent. A 65-kD fragment was immunoprecipitated by antibodies against peptides between residues 354 and 1061 but not beyond residue 1062. Binding experiments utilizing combinations of native protein, expression-PCR-synthesized EBA-175 polypeptides, peptide synthesis, and antibodies, demonstrated that sialic acid-independent binding could be further mapped to a small (about 40-amino acid) homologous part of the dimorphic allelic region of EBA-175, residues 898-938 (Camp strain numbering). These data support a two-step binding hypothesis and are discussed in relation to the formation of a junction between the merozoite and the erythrocyte, and the finding that after the interaction of some viruses with specific cellular receptors, they undergo conformational changes or cleavage permitting membrane fusion with the host cell. C1 WALTER REED ARMY INST RES, DEPT IMMUNOL, WASHINGTON, DC 20307 USA. JOHNS HOPKINS UNIV, DEPT IMMUNOL & INFECT DIS, BALTIMORE, MD 21205 USA. RP KAIN, KC (reprint author), TORONTO HOSP, DEPT MED, DIV INFECT DIS, TROP DIS UNIT, 200 ELIZABETH ST, TORONTO M5G 2C4, ON, CANADA. RI Lanar, David/B-3560-2011 NR 31 TC 43 Z9 43 U1 0 U2 0 PU ROCKEFELLER UNIV PRESS PI NEW YORK PA 1114 FIRST AVE, 4TH FL, NEW YORK, NY 10021 USA SN 0022-1007 EI 1540-9538 J9 J EXP MED JI J. Exp. Med. PD NOV 1 PY 1993 VL 178 IS 5 BP 1497 EP 1505 DI 10.1084/jem.178.5.1497 PG 9 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA MD953 UT WOS:A1993MD95300004 PM 8228803 ER PT J AU MUNAVALLI, S ROSSMAN, DI ROHRBAUGH, DK FERGUSON, CP BUETTNER, L AF MUNAVALLI, S ROSSMAN, DI ROHRBAUGH, DK FERGUSON, CP BUETTNER, L TI SYNTHESIS AND BIOLOGICAL SCREENING OF TRIFLUOROMETHYLTHIOARSENICALS SO JOURNAL OF FLUORINE CHEMISTRY LA English DT Article AB The title compounds have been prepared from the reaction of trifluoromethylthiocopper and alkyl mono- and di-haloarsines. This communication describes their synthesis, biological screening and mass spectral fragmentation behavior. C1 USA,EDGEWOOD RES DEV & ENGN CTR,ABERDEEN PROVING GROUND,MD 21010. RP MUNAVALLI, S (reprint author), GEOCENTERS INC,FT WASHINGTON,MD 20744, USA. NR 30 TC 22 Z9 22 U1 0 U2 0 PU ELSEVIER SCIENCE SA LAUSANNE PI LAUSANNE 1 PA PO BOX 564, 1001 LAUSANNE 1, SWITZERLAND SN 0022-1139 J9 J FLUORINE CHEM JI J. Fluor. Chem. PD NOV PY 1993 VL 65 IS 1-2 BP 15 EP 19 DI 10.1016/S0022-1139(00)80466-2 PG 5 WC Chemistry, Inorganic & Nuclear; Chemistry, Organic SC Chemistry GA MK677 UT WOS:A1993MK67700004 ER PT J AU KAIN, KC BROWN, AE MIRABELLI, L WEBSTER, HK AF KAIN, KC BROWN, AE MIRABELLI, L WEBSTER, HK TI DETECTION OF PLASMODIUM-VIVAX BY POLYMERASE CHAIN-REACTION IN A FIELD-STUDY SO JOURNAL OF INFECTIOUS DISEASES LA English DT Note ID FALCIPARUM; BLOOD; DNA; DIAGNOSIS; MALARIA AB Detection and typing of Plasmodium vivax by the polymerase chain reaction (PCR) was evaluated in a prospective blinded comparative field study in Thailand. PCR amplification of the circumsporozoite (CS) gene was compared with microscopy for the detection of P. vivax in blood samples from 174 Thai Rangers and 50 malaria-free Bangkok residents. For PCR analysis, filter paper specimens collected by finger prick were randomly processed and blindly interpreted for the presence of the CS gene of P. vivax. The VK210 and VK247 CS variants of P. vivax were detected by specific fluorescein or radiolabeled oligoprobes. Autoradiography with P-32-labeled probes and enhanced chemoluminescent detection with fluorescein-labeled probes identified 91% and 96%, respectively, of 119 microscopically confirmed infections; both systems detected <100 parasites/muL. Compared with microscopy, the specificity of PCR and radiometric or enhanced chemoluminescent detection was 96% and 90%, respectively. The ease of collection and transport of filter-paper specimens combined with the sensitive and specific detection of allelic genes of P. vivax by PCR suggests that this method may prove to be a valuable tool for epidemiologic and heterogeneity studies of P. vivax. C1 ARMED FORCES RES INST MED SCI, BANGKOK, THAILAND. RP KAIN, KC (reprint author), TORONTO HOSP, DIV INFECT DIS, TROP DIS UNIT, 200 ELIZABETH ST, TORONTO M5G 2C4, ON, CANADA. NR 15 TC 57 Z9 59 U1 0 U2 0 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 EI 1537-6613 J9 J INFECT DIS JI J. Infect. Dis. PD NOV PY 1993 VL 168 IS 5 BP 1323 EP 1326 PG 4 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA MC890 UT WOS:A1993MC89000043 PM 8228373 ER PT J AU LINTHICUM, KJ LOGAN, TM AF LINTHICUM, KJ LOGAN, TM TI FEEDING NYMPHS OF HYALOMMA-TRUNCATUM (ACARI, IXODIDAE) ON GUINEA-PIGS PREVIOUSLY EXPOSED TO NYMPHS SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Note DE HYALOMMA TRUNCATUM; FEEDING; NYMPHS ID RESISTANCE AB The ability of nymphal Hyalomma truncatum Koch to feed on guinea pigs previously exposed to nymphal ticks was studied by measuring the percentage of ticks engorging and molting, their engorged weight, and hemoglobin content. Four guinea pigs were infested with 20, 40, 80, and 200 nymphs, respectively, on three occasions at 21-d intervals, followed by a fourth infestation after another 21-d interval with 100 nymphs. Guinea pigs originally infested with 20 and 80 nymphs were infested a fifth time with 100 nymphs 3 mo after the fourth infestation. Guinea pips originally infested with 40 and 200 nymphs were infested a fifth time with 100 nymphs 6 mo after the fourth infestation. There was a significant decrease, below infestation I levels, in the number of ticks engorging on each guinea pig during infestations IV and V. Whereas all nymphs molted after infestation I, the percentage of nymphs molting after infestation V ranged from 0 to 34%. For ticks infested on each of the guinea pigs, the percentage molting after infestations III-V were significantly lower than those observed after infestation I. A significant decrease in the mean weight of engorged ticks was observed starting at infestation III. Mean hemoglobin content of ticks declined significantly at infestation II. The response elicited by feeding nymphs appeared to last at least 6 mo. C1 USA,ARMY MED RES INST INFECT DIS,DEPT EPIDEMIOL,DIV DIS ASSESSMENT,FREDERICK,MD 21702. RP LINTHICUM, KJ (reprint author), USA,ARMED FORCES RES INST MED SCI,MED COMPONENT,DEPT ENTOMOL,APO AP 96546,BANGKOK,THAILAND. NR 15 TC 0 Z9 0 U1 0 U2 0 PU ENTOMOL SOC AMER PI LANHAM PA 9301 ANNAPOLIS RD, LANHAM, MD 20706 SN 0022-2585 J9 J MED ENTOMOL JI J. Med. Entomol. PD NOV PY 1993 VL 30 IS 6 BP 1064 EP 1067 PG 4 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA ME498 UT WOS:A1993ME49800015 PM 8271249 ER PT J AU CABRAL, JA MCCHESNEY, JD MILHOUS, WK AF CABRAL, JA MCCHESNEY, JD MILHOUS, WK TI A NEW ANTIMALARIAL QUASSINOID FROM SIMABA-GUIANENSIS SO JOURNAL OF NATURAL PRODUCTS LA English DT Article ID INVITRO; DRUGS AB Two antimalarial quassinoids, gutolactone [1] and simalikalactone D [2], have been characterized by bioactivity-directed fractionation from the bark of Simaba guianensis collected near Manaus, Brazil. Compound 2 was previously isolated from Simaba multiflora and Quassia africana and shown to be an active antimalarial in vitro. This is the first occurrence of 1. The structure of the novel quassinoid was established by spectral methods including 2D nmr spectroscopy. C1 UNIV MISSISSIPPI,PHARMACEUT SCI RES INST,UNIVERSITY,MS 38677. INST NACL PESQUISAS,COORDENACAO PESQUISAS PROD NAT,BR-69000 MANAUS,AMAZONAS,BRAZIL. WALTER REED ARMY INST RES,DIV EXPTL THERAPEUT,MALARIA RES LAB,WASHINGTON,DC 20307. NR 14 TC 38 Z9 40 U1 0 U2 0 PU AMER SOC PHARMACOGNOSY PI CINCINNATI PA LLOYD LIBRARY & MUSEUM 917 PLUM ST, CINCINNATI, OH 45202 SN 0163-3864 J9 J NAT PROD JI J. Nat. Prod. PD NOV PY 1993 VL 56 IS 11 BP 1954 EP 1961 DI 10.1021/np50101a014 PG 8 WC Plant Sciences; Chemistry, Medicinal; Pharmacology & Pharmacy SC Plant Sciences; Pharmacology & Pharmacy GA MH120 UT WOS:A1993MH12000014 PM 8289064 ER PT J AU ENGEL, CC ENGEL, AL CAMPBELL, SJ MCFALL, ME RUSSO, J KATON, W AF ENGEL, CC ENGEL, AL CAMPBELL, SJ MCFALL, ME RUSSO, J KATON, W TI POSTTRAUMATIC-STRESS-DISORDER SYMPTOMS AND PRECOMBAT SEXUAL AND PHYSICAL ABUSE IN DESERT-STORM VETERANS SO JOURNAL OF NERVOUS AND MENTAL DISEASE LA English DT Article ID BORDERLINE PERSONALITY-DISORDER; URBAN-POPULATION; TRAUMATIC EVENTS; VIETNAM VETERANS; YOUNG-ADULTS; CHILDHOOD; VALIDITY; VICTIMS; PTSD; WAR AB The purpose of this research was to study the association between precombat sexual and physical abuse and combat-related posttraumatic stress disorder (PTSD) symptoms in a clinical sample of male and female Desert Storm veterans. Two hundred ninety-seven veterans provided data on precombat sexual and physical abuse, precombat psychiatric problems, sociodemographics, Desert Storm combat exposure, and PTSD symptomatology using the Mississippi Scale. Men reported significantly higher levels of combat exposure, and women described significantly more frequent precombat abuse. Precombat-abused veterans reported more frequent precombat psychiatric histories. Analysis of covariance revealed that gender significantly modified the impact of precombat abuse on combat-related and other PTSD symptomatology after adjusting for precombat psychiatric history and level of combat exposure. Specifically, females describing precombat abuse reported much greater PTSD symptomatology than did females denying precombat abuse. These results in conjunction with previous research suggest that a relationship between precombat abuse and combat-related PTSD may exist. Prospective, longitudinal studies of both men and women are needed. C1 USA,DIV CALVARY 1,FT HOOD,TX. RP ENGEL, CC (reprint author), UNIV WASHINGTON,SCH MED,DEPT PSYCHIAT & BEHAV SCI,RP-10,SEATTLE,WA 98195, USA. NR 29 TC 92 Z9 92 U1 1 U2 3 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-3018 J9 J NERV MENT DIS JI J. Nerv. Ment. Dis. PD NOV PY 1993 VL 181 IS 11 BP 683 EP 688 DI 10.1097/00005053-199311000-00006 PG 6 WC Clinical Neurology; Psychiatry SC Neurosciences & Neurology; Psychiatry GA MG197 UT WOS:A1993MG19700006 PM 8228950 ER PT J AU NEWSOME, RD DITZLER, T AF NEWSOME, RD DITZLER, T TI ASSESSING ALCOHOLIC DENIAL - FURTHER EXAMINATION OF THE DENIAL RATING-SCALE SO JOURNAL OF NERVOUS AND MENTAL DISEASE LA English DT Article AB The reliability, validity, and heuristic value of Goldsmith and Green's (J. Nerv. Ment. Dis. 176:614-620, 1988) Denial Rating Scale (DRS) are examined in an inpatient treatment setting. This replication study includes 647 cases. The same strong relationship between clinical change and program completion as found by Goldsmith and Green is identified. An ordinal predictive validity for the DRS regarding program completion that was not found by Goldsmith and Green is also identified. Utility for improving patient treatment plans through DRS results is identified. The heuristic value of the DRS in helping an alcoholism counseling staff maintain treatment focus is discussed. It is recommended that treatment centers incorporate systematic assessment of denial over the course of treatment as a means to facilitate staff focus on the primacy of addiction. C1 SCOTT MED CTR,SCOTT AFB,IL 62225. TRIPLER ARMY MED CTR,TRISERV ALCOHOLISM RECOVERY FACIL,HONOLULU,HI 96859. NR 4 TC 6 Z9 6 U1 0 U2 1 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-3018 J9 J NERV MENT DIS JI J. Nerv. Ment. Dis. PD NOV PY 1993 VL 181 IS 11 BP 689 EP 694 DI 10.1097/00005053-199311000-00007 PG 6 WC Clinical Neurology; Psychiatry SC Neurosciences & Neurology; Psychiatry GA MG197 UT WOS:A1993MG19700007 PM 8228951 ER PT J AU GIJBELS, K PROOST, P MASURE, S CARTON, H BILLIAU, A OPDENAKKER, G AF GIJBELS, K PROOST, P MASURE, S CARTON, H BILLIAU, A OPDENAKKER, G TI GELATINASE-B IS PRESENT IN THE CEREBROSPINAL-FLUID DURING EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS AND CLEAVES MYELIN BASIC-PROTEIN SO JOURNAL OF NEUROSCIENCE RESEARCH LA English DT Article DE GELATINASE ACTIVITY; DEMYELINATION; MULTIPLE SCLEROSIS ID CENTRAL-NERVOUS-SYSTEM; EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; MULTIPLE-SCLEROSIS; MATRIX METALLOPROTEINASES; PROTEOLIPID PROTEIN; TISSUE INHIBITOR; SJL/J MICE; INTERLEUKIN-6; DEMYELINATION; MACROPHAGES AB Gelatinases in inflammatory demyelinating diseases of the central nervous system (CNS) were studied using actively induced experimental autoimmune encephalomyelitis (EAE) in mice as a model system. Clinical disease scores correlated in time and in intensity with pathology parameters such as cytosis in the cerebrospinal fluid (CSF), inflammatory infiltrates, and demyelination in the CNS. Zymographic analysis was employed to measure gelatinases A and B in the CSF from individual animals. According to their apparent molecular weight (MW), gelatinases A and B appeared with a MW of 65 and 95 kDa, respectively. The 65 kDa form was present in all samples, even in those derived from non-induced animals, whereas the 95 kDa form was present only in samples from animals developing EAE. The levels of 95 and 65 kDa gelatinase correlated with the CSF cytosis. In vitro digestion of myelin basic protein (MBP) with gelatinase B and analysis of the cleavage products by protein sequence analysis pinpointed two cleavage sites in conserved regions of MBP. Gelatinase production within the CNS may constitute an important pathogenic mechanism for both the disruption of the blood-brain barrier and the destruction of myelin, as observed in several neuroinflammatory disorders. (C) 1993 Wiley-Liss, Inc. C1 USA,SCH MED,REGA INST,FT RUCKER,AL 36360. CATHOLIC UNIV LEUVEN,SCH MED,DEPT BRAIN & BEHAV RES,B-3000 LOUVAIN,BELGIUM. NR 41 TC 157 Z9 157 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0360-4012 J9 J NEUROSCI RES JI J. Neurosci. Res. PD NOV 1 PY 1993 VL 36 IS 4 BP 432 EP 440 DI 10.1002/jnr.490360409 PG 9 WC Neurosciences SC Neurosciences & Neurology GA ME272 UT WOS:A1993ME27200008 PM 7505841 ER PT J AU DRAGOLICH, WE PASHLEY, DH BRENNAN, WA ONEAL, RB HORNER, JA VANDYKE, TE AF DRAGOLICH, WE PASHLEY, DH BRENNAN, WA ONEAL, RB HORNER, JA VANDYKE, TE TI AN IN-VITRO STUDY OF DENTINAL TUBULE OCCLUSION BY FERRIC OXALATE SO JOURNAL OF PERIODONTOLOGY LA English DT Article DE SMEAR LAYER; DENTIN; SENSITIVE/THERAPY; FERRIC OXALATE/THERAPEUTIC USE ID HYDRAULIC CONDUCTANCE; HYPERSENSITIVITY; PERMEABILITY; AGENTS; TETRACYCLINE; SENSITIVITY; ETIOLOGY; SURFACES; INVITRO; ENAMEL AB THIS STUDY EXAMINED FERRIC OXALATE'S ability to occlude dentinal tubules both in the presence of a smear layer and after its removal. Radicular dentinal chips were prepared with a smear layer created from a high speed carbide bur. The dentinal chips were then grouped as follows: 1) those with the smear layer remaining intact; 2) those sonicated for 7 minutes; 3) those treated with 10% tetracycline HCl; 4) those treated with 0.5M EDTA; 5) those treated with 20% citric acid; or 6) those treated with saturated citric acid. Six percent ferric oxalate was applied for 1 minute to the dentinal chips under blinded conditions. The chips were examined under SEM and the number of small and large crystals formed were counted. The results indicate that a decrease in the number of small crystals occurs following pretreatment of the smear layer by chemical means. An increased variability in size and shape of the crystals is also observed when no chemical pretreatment is used. Thus, relative to the number of crystals that form, no chemical pretreatment of radicular dentin is indicated prior to application of ferric oxalate in the treatment of root sensitivity. C1 MED COLL GEORGIA,SCH DENT,AUGUSTA,GA 30912. EASTMAN DENT CTR,ROCHESTER,NY. BLOCK DRUG CO,SENSODYNE SEALANT,JERSEY CITY,NJ. RP DRAGOLICH, WE (reprint author), USA,DENT ACT,PERIODONTAL RESIDENCY PROGRAM,FT GORDON,GA 30905, USA. NR 31 TC 26 Z9 28 U1 0 U2 1 PU AMER ACAD PERIODONTOLOGY PI CHICAGO PA 737 NORTH MICHIGAN AVENUE, SUITE 800, CHICAGO, IL 60611-2690 SN 0022-3492 J9 J PERIODONTOL JI J. Periodont. PD NOV PY 1993 VL 64 IS 11 BP 1045 EP 1051 PG 7 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA ML644 UT WOS:A1993ML64400005 PM 8295089 ER PT J AU LILLEY, JS PENGELLY, SL AF LILLEY, JS PENGELLY, SL TI WIND-TUNNEL EVALUATION OF MID-AIRFRAME INSTALLED TURBOJET ENGINES SO JOURNAL OF PROPULSION AND POWER LA English DT Article AB A series of power-on wind-tunnel tests have been conducted to evaluate the installed performance of mid-airframe mounted tactical-missile turbojet sustainers. Two low-cost, expendable turbojet engine designs were installed in a high-fidelity wind-tunnel model of a specific tactical missile. To accommodate the unique installation requirements, each engine design incorporated bifurcated pitot inlets and side-exhausting bifurcated exhaust ducts. Each installed engine was fully functional and was intended to closely replicate the in-flight operational response. Power-on wind-tunnel evaluations were conducted for each engine model that encompassed a wide range of sea level, steady-state flight conditions. The test condition variables evaluated were Mach number, pitch angle, yaw angle, engine throttle setting, and control fin deflection. Missile axial force data were acquired to determine installed, delivered engine net thrust. In addition, extensive thermal instrumentation was installed on the model to evaluate the influence of the turbojet exhaust plume on the aft section of the missile. A detailed description of the test program is provided. Detailed descriptions of the hardware configuration and test variables are presented. Presented are discussions of theoretical engine performance models, experimental installed performance results, projections of overall missile performance, and evaluations of the effect of pitch on engine performance. A detailed evaluation of the thermal impact of turbojet operation is provided. Discussions of the thermal impact of pitch, yaw, and fin deflection angles are presented. The results presented demonstrate that both sustainer configurations, successfully operated in an installed configuration under in-flight conditions, delivered adequate installed performance to satisfy missile system requirements, and had minimal adverse thermal impact on the airframe. The results of the evaluation fully verify the viability of employing turbojet engines in a mid-airframe installation. C1 BOEING DEF & SPACE GRP,HUNTSVILLE,AL 35898. RP LILLEY, JS (reprint author), USA,MISSILE COMMAND,PROP DIRECTORATE,REDSTONE ARSENAL,AL 35898, USA. NR 4 TC 0 Z9 0 U1 0 U2 0 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091 SN 0748-4658 J9 J PROPUL POWER JI J. Propul. Power PD NOV-DEC PY 1993 VL 9 IS 6 BP 858 EP 866 DI 10.2514/3.23700 PG 9 WC Engineering, Aerospace SC Engineering GA MG559 UT WOS:A1993MG55900009 ER PT J AU SHOOP, SA AF SHOOP, SA TI THAWING SOIL STRENGTH MEASUREMENTS FOR PREDICTING VEHICLE PERFORMANCE SO JOURNAL OF TERRAMECHANICS LA English DT Article AB The CRREL Instrumented Vehicle (CIV), shear annulus, direct shear and triaxial compression devices were used to characterize the strength of thawed and thawing soil. Strength was evaluated in terms of the Mohr-Coulomb failure parameters c' and phi', which can be used in simple models to predict the tractive performance of vehicles. Use of an instrumented wheel (like those of the CIV) is proposed for terrain strength characterization for traction prediction because the conditions created by a tire slipping on a soil surface are exactly duplicated. The c' and phi' values from a portable shear annulus overpredict traction because of the curved nature of the soil failure envelope in the region of low normal stress applied by a portable annulus. Of all the tests, the direct shear test yielded the highest phi' value, due to its slow deformation rate and drained conditions. The triaxial test produced results closest to those of the instrumented wheel. For all methods, phi' increases with soil moisture but decreases rapidly beyond the liquid limit of the soil. The phi' measured with the vehicle was also found to be strongly influenced by the freeze-thaw layering of the soil. RP SHOOP, SA (reprint author), USA,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 0 TC 4 Z9 4 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0022-4898 J9 J TERRAMECHANICS JI J. Terramech. PD NOV PY 1993 VL 30 IS 6 BP 405 EP 418 DI 10.1016/0022-4898(93)90034-U PG 14 WC Engineering, Environmental SC Engineering GA ND147 UT WOS:A1993ND14700002 ER PT J AU DESMOND, PM CLARK, J THOMPSON, IM ZEIDMAN, EJ MUELLER, EJ AF DESMOND, PM CLARK, J THOMPSON, IM ZEIDMAN, EJ MUELLER, EJ TI MORBIDITY WITH CONTEMPORARY PROSTATE BIOPSY SO JOURNAL OF UROLOGY LA English DT Article DE PROSTATE; BIOPSY; COMPLICATIONS ID URINARY-TRACT INFECTION; TRANSRECTAL BIOPSY; NEEDLE-BIOPSY AB To determine the incidence of complications associated with contemporary prostate biopsy, a review of 670 men undergoing transrectal prostate biopsy using 18 gauge biopsy needles was conducted. Of the men 580 received 1 to 3 days of ciprofloxacin antibiotic prophylaxis. A total of 16 patients (2.1%) suffered complications of whom 4 (0.6%) required hospitalization. These data demonstrate the low morbidity associated with contemporary transrectal prostate biopsy. RP DESMOND, PM (reprint author), BROOKE ARMY MED CTR,UROL SERV,SAN ANTONIO,TX, USA. RI Desmond, Patricia /D-1966-2014; OI Desmond, Patricia /0000-0002-4803-6323; Clark, Joseph/0000-0002-3817-4343 NR 12 TC 65 Z9 66 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-5347 J9 J UROLOGY JI J. Urol. PD NOV PY 1993 VL 150 IS 5 BP 1425 EP 1426 PN 1 PG 2 WC Urology & Nephrology SC Urology & Nephrology GA MC576 UT WOS:A1993MC57600026 PM 8411416 ER PT J AU KUHN, EJ KURNOT, RA SESTERHENN, IA CHANG, EH MOUL, JW AF KUHN, EJ KURNOT, RA SESTERHENN, IA CHANG, EH MOUL, JW TI EXPRESSION OF THE C-ERBB-2 (HER-2/NEU) ONCOPROTEIN IN HUMAN PROSTATIC-CARCINOMA SO JOURNAL OF UROLOGY LA English DT Article DE PROSTATIC NEOPLASMS; ONCOGENE PRODUCTS; ONCOGENES; DNA, NEOPLASM ID GROWTH-FACTOR-RECEPTOR; ERB B-2/NEU PROTOONCOGENE; HUMAN-BREAST CANCER; PROGNOSTIC-SIGNIFICANCE; OVARIAN-CANCER; BLADDER-CANCER; POOR SURVIVAL; NEU ONCOGENE; CELL-LINES; AMPLIFICATION AB The objective of this study was to determine the expression of the c-erbB-2 oncoprotein via immunohistochemistry of archival clinically localized human prostate cancers and to compare these results to known clinical prognostic factors. In addition, positive staining cases were subjected to differential polymerase chain reaction to assess for c-erbB-2 gene amplification. Immunohistochemical staining with a polyclonal antibody (pAb 1) was performed on archival radical prostatectomy specimens. To standardize the staining, positive and negative control material was generated using c-erbB-2 transfected NIH3T3 cells grown on agar plugs, formalin fixed, paraffin embedded and processed on glass slides for immunohistochemistry. Definite positive membranous staining was detected in 18 of 53 neoplastic cases (34%). In addition, 9 cases of benign prostatic hyperplasia were stained without evidence of c-erbB-2 expression detected. Either focal or diffuse membranous staining was identified in 6 of 27 (22%) well, 8 of 20 (40%) moderately and 4 of 6 (66%) poorly differentiated tumors (p = 0.03, chi-square test for trend). Positive staining occurred in 6 of 18 patients (33%) with pathological stage B and 12 of 33 (36%) with pathological stage C disease. At a mean of 36 months, complete followup was available for 16 of the 18 positive cases and 30 of the 35 negative cases. For stage B 1 of 6 positive (16.7%) versus 1 of 12 negative (8%) staining cases showed progression (p = 1.0). For stage C 7 of 12 positive (58.3%) versus 9 of 21 negative (42.9%) cases showed progression (p = 0.48). Deoxyribonucleic acid was extracted from the exact same archival paraffin blocks for the c-erbB-2 protein positive cases and subjected to differential polymerase chain reaction analysis, which revealed no c-erbB-2 gene amplification. This study demonstrates that approximately a third of all clinically localized prostate cancers express the c-erbB-2 oncoprotein via immunohistochemistry using pAb-1 on archival material, c-erbB-2 oncoprotein expression does not appear to be a prognostic marker for prostate cancer although our results are preliminary and, although oncoprotein expression was detected, no positive case demonstrated deoxyribonucleic acid amplification. C1 UNIFORMED SERV UNIV HLTH SCI, DEPT PATHOL & SURG, BETHESDA, MD 20814 USA. ARMED FORCES INST PATHOL, DEPT GENITOURINARY PATHOL, WASHINGTON, DC 20306 USA. WALTER REED ARMY MED CTR, UROL SERV, WASHINGTON, DC 20307 USA. WALTER REED ARMY MED CTR, DEPT CLIN INVEST, WASHINGTON, DC 20307 USA. NR 58 TC 138 Z9 141 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0022-5347 EI 1527-3792 J9 J UROLOGY JI J. Urol. PD NOV PY 1993 VL 150 IS 5 BP 1427 EP 1433 PN 1 PG 7 WC Urology & Nephrology SC Urology & Nephrology GA MC576 UT WOS:A1993MC57600027 PM 8105108 ER PT J AU KEARSE, WS SEAY, TM THOMPSON, IM AF KEARSE, WS SEAY, TM THOMPSON, IM TI THE LONG-TERM RISK OF DEVELOPMENT OF PROSTATE-CANCER IN PATIENTS WITH BENIGN PROSTATIC HYPERPLASIA - CORRELATION WITH STAGE-A1 DISEASE SO JOURNAL OF UROLOGY LA English DT Article DE PROSTATE; PROSTATIC NEOPLASMS; PROSTATIC HYPERTROPHY ID EXTENDED FOLLOW-UP; CARCINOMA; PROGNOSIS; ADENOCARCINOMA; GRADE AB Although historical data generally attest to a relatively benign course for stage A1 prostate cancer, at least some recent studies suggest that with prolonged followup patients have a significant risk of disease progression. This study was done with the hypothesis that such disease progression is a function of patient age and close, prolonged followup, and not the mere presence of stage A1 disease. A total of 304 patients who underwent transurethral resection of the prostate for histologically confirmed benign prostatic hyperplasia was reviewed, with a minimum followup of 8 years. Of 269 patients with full followup data 187 (70%) are alive without prostate cancer and 61 (23%) died without development of the disease. A total of 21 patients (7.8%) had clinically apparent prostate cancer at a mean of 7.0 years following transurethral resection, of whom 3 (14%) died of prostate cancer and 1 died of other causes. These data suggest that the risk of progression and death from prostate cancer may not be significantly greater in patients with stage A1 disease than in those reported to have benign disease at transurethral prostatectomy. C1 USAF,WILFORD HALL MED CTR,SAN ANTONIO,TX. RP KEARSE, WS (reprint author), BROOKE ARMY MED CTR,DEPT UROL,SAN ANTONIO,TX, USA. NR 19 TC 7 Z9 8 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-5347 J9 J UROLOGY JI J. Urol. PD NOV PY 1993 VL 150 IS 5 BP 1746 EP 1748 PN 2 PG 3 WC Urology & Nephrology SC Urology & Nephrology GA MC578 UT WOS:A1993MC57800040 PM 7692112 ER PT J AU LI, SQ POLONIS, V ISOBE, H ZAGHOUANI, H GUINEA, R MORAN, T BONA, C PALESE, P AF LI, SQ POLONIS, V ISOBE, H ZAGHOUANI, H GUINEA, R MORAN, T BONA, C PALESE, P TI CHIMERIC INFLUENZA-VIRUS INDUCES NEUTRALIZING ANTIBODIES AND CYTOTOXIC T-CELLS AGAINST HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 SO JOURNAL OF VIROLOGY LA English DT Article ID LYMPHOCYTES-T; SYNTHETIC PEPTIDES; VACCINIA VIRUS; EPITOPE; HIV-1; HEMAGGLUTININ; DETERMINANT; ENVELOPE; GP160; GLYCOPROTEIN AB Expression vectors based on DNA or plus-stranded RNA viruses are being developed as vaccine carriers directed against various pathogens. Less is known about the use of negative-stranded RNA viruses, whose genomes have been refractory to direct genetic manipulation. Using a recently described reverse genetics method, we investigated whether influenza virus is able to present antigenic structures from other infectious agents. We engineered a chimeric influenza virus which expresses a 12-amino-acid peptide derived from the V3 loop of gp120 of human immunodeficiency virus type 1 (HIV-1) MN. This peptide was inserted into the loop of antigenic site B of the influenza A/WSN/33 virus hemagglutinin (HA). The resulting chimeric virus was recognized by specific anti-V3 peptide antibodies and a human anti-gp120 monoclonal antibody in both hemagglutination inhibition and neutralization assays. Mice immunized with the chimeric influenza virus produced anti-HIV antibodies which were able to bind to synthetic V3 peptide, to precipitate gp120, and to neutralize MN virus in human T-cell culture system. In addition, the chimeric virus was also capable of inducing cytotoxic T cells which specifically recognize the HIV sequence. These results suggest that influenza virus can be used as an expression vector for inducing both B- and T-cell-mediated immunity against other infectious agents. C1 CUNY MT SINAI SCH MED,DEPT MICROBIOL,NEW YORK,NY 10029. WALTER REED ARMY INST RES,DEPT RETROVIRAL RES,WASHINGTON,DC 20307. OI Palese, Peter/0000-0002-0337-5823 FU NIAID NIH HHS [P01-AI24460] NR 45 TC 66 Z9 67 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0022-538X J9 J VIROL JI J. Virol. PD NOV PY 1993 VL 67 IS 11 BP 6659 EP 6666 PG 8 WC Virology SC Virology GA MC016 UT WOS:A1993MC01600037 PM 7692083 ER PT J AU BARTH, J AF BARTH, J TI MINDING MR MARKET - 10 YEARS ON WALL-STREET WITH GRANTS INTEREST-RATE OBSERVER - GRANT,J SO LIBRARY JOURNAL LA English DT Book Review RP BARTH, J (reprint author), US MIL ACAD LIB,W POINT,NY, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 SN 0363-0277 J9 LIBR J JI Libr. J. PD NOV 1 PY 1993 VL 118 IS 18 BP 108 EP 108 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA ME965 UT WOS:A1993ME96500153 ER PT J AU CHISICK, MC MOTTERN, J AF CHISICK, MC MOTTERN, J TI MARKETING AND UTILIZATION OF THE ACTIVE-DUTY DEPENDENTS DENTAL INSURANCE PLAN SO MILITARY MEDICINE LA English DT Article AB Based on a random, representative sample of 2,733 officer and 7,938 enlisted Army enrollees in the Active Duty Dependent's Dental Insurance Plan (ADDDIP), we found that soldiers turned to many sources to learn about the plan and that oral sources were consulted more commonly than written sources. More than 40% of Army enrollees have never used the plan. Officer dependents have used the ADDDIP to a fuller extent than enlisted dependents. Over half of Army enrollees felt that program enrollment should be renewed automatically. The best-liked features of the ADDDIP included good cost value, known services covered, and access to a single family dentist. RP CHISICK, MC (reprint author), USA,INST DENT RES,EPIDEMIOL SECT,FT GEORGE G MEADE,MD, USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD NOV PY 1993 VL 158 IS 11 BP 693 EP 696 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA MH568 UT WOS:A1993MH56800004 PM 8284051 ER PT J AU MCCARROLL, JE ORMAN, DT LUNDY, AC AF MCCARROLL, JE ORMAN, DT LUNDY, AC TI CLIENTS, PROBLEMS, AND DIAGNOSES IN A MILITARY COMMUNITY MENTAL-HEALTH CLINIC - A 20-MONTH STUDY SO MILITARY MEDICINE LA English DT Article AB A descriptive epidemiologic study was performed using intake data from an Army community mental health clinic. This clinic was on a U.S. Army nontraining post; data were collected over a 20-month period. Two diagnoses, occupational problem and phase of life or other life circumstance problem, were utilized by clinicians in 51% of all cases. Axis I diagnoses were found in 21% of the cases and medication was prescribed in 7%. Women were over-represented relative to men. We concluded that the patterns of diagnoses reflected the demand characteristics of the military environment. One implication of this study is that psychiatric care must be examined in the context of the community and not just as an administrative or economic system. RP MCCARROLL, JE (reprint author), WALTER REED ARMY INST RES,DEPT MIL PSYCHIAT,WASHINGTON,DC 20307, USA. NR 0 TC 10 Z9 12 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD NOV PY 1993 VL 158 IS 11 BP 701 EP 705 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA MH568 UT WOS:A1993MH56800007 PM 8284054 ER PT J AU MCCARROLL, JE ORMAN, DT LUNDY, AC AF MCCARROLL, JE ORMAN, DT LUNDY, AC TI DIFFERENCES IN SELF-REFERRALS AND SUPERVISOR-REFERRALS TO A MILITARY MENTAL-HEALTH CLINIC SO MILITARY MEDICINE LA English DT Article AB Supervisor- and self-referrals-for outpatient mental health care were studied to determine demographic and clinical differences. Supervisor-referrals (n=730) were younger, reported fewer problems, and received less severe diagnoses than the self-referrals. Self-referrals (n=1,103) received more depressive and anxiety diagnoses and more medications. They were also more afraid to ask for help, were more likely to not know where to go for help, say that ''no one cares,'' fear disclosure, and to fear the outcome than the supervisor-referrals. Supervisor-referral may permit earlier intervention into client problems, but the nature of the social contingencies contributing to referral requires more research. RP MCCARROLL, JE (reprint author), WALTER REED ARMY INST RES,DEPT MIL PSYCHIAT,WASHINGTON,DC 20307, USA. NR 0 TC 9 Z9 9 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD NOV PY 1993 VL 158 IS 11 BP 705 EP 708 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA MH568 UT WOS:A1993MH56800008 PM 8284055 ER PT J AU ARMSTRONG, SC TOOK, KJ AF ARMSTRONG, SC TOOK, KJ TI PSYCHIATRIC MANAGED CARE AT A RURAL MEDDAC SO MILITARY MEDICINE LA English DT Article AB Mental health costs at General Leonard Wood Army Community Hospital (GLWACH) have risen every year. In 1990, $2.7 million had been spent on CHAMPUS mental health costs, 58% of the entire CHAMPUS costs for the hospital's catchment area. Gateway to Care, a plan of coordinated managed care conceived by Health Services Command, was initiated at GLWACH to give the commander and providers more flexibility to control costs and improve access to care. Five major changes were made under GLWACH's mental health coordinated care project. In the first full year of the project, CHAMPUS net costs were reduced to $1.4 million while more comprehensive care was provided to beneficiaries. Cost reduction came primarily from dramatically increasing the size and scope of outpatient care to reduce inpatient admissions. RP ARMSTRONG, SC (reprint author), WALTER REED ARMY MED CTR,WASHINGTON,DC 20307, USA. NR 0 TC 3 Z9 3 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD NOV PY 1993 VL 158 IS 11 BP 717 EP 721 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA MH568 UT WOS:A1993MH56800012 PM 8284059 ER PT J AU LANDE, RG AF LANDE, RG TI ALCOHOL - THE CLINICIAN ROLE IN EVALUATING LEGAL RESPONSIBILITY SO MILITARY MEDICINE LA English DT Article AB Alcohol-related misconduct poses a challenge for society, the legal system, and the medical profession. The debate is centered on alcohol abuse and the determination of responsibility for misbehavior. In assessing responsibility, the legal system often requests the expertise of the medical professional. The knowledgeable clinician can contribute to the just resolution of complex medico-legal cases. The best contribution considers medical facts in relation to the evolution of legal thinking. This article explores the historical, social, and legal approaches to alcohol-related misconduct. The article concludes with a discussion of a model clinical assessment. RP LANDE, RG (reprint author), WALTER REED ARMY MED CTR,DEPT PSYCHIAT,WASHINGTON,DC 20012, USA. NR 0 TC 2 Z9 2 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD NOV PY 1993 VL 158 IS 11 BP 748 EP 751 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA MH568 UT WOS:A1993MH56800019 PM 8284066 ER PT J AU CANCIO, LC AF CANCIO, LC TI CHEMICAL CASUALTY DECONTAMINATION - RESPONSE SO MILITARY MEDICINE LA English DT Letter RP CANCIO, LC (reprint author), BROOKE ARMY MED CTR,GEN SURG SERV,FT SAM HOUSTON,TX 78234, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD NOV PY 1993 VL 158 IS 11 BP A6 EP A7 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA MH568 UT WOS:A1993MH56800002 ER PT J AU FLOWERS, R AF FLOWERS, R TI CHEMICAL CASUALTY DECONTAMINATION SO MILITARY MEDICINE LA English DT Letter RP FLOWERS, R (reprint author), USA,MED DEPT CTR & SCH,FT SAM HOUSTON,TX 78234, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD NOV PY 1993 VL 158 IS 11 BP A6 EP A6 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA MH568 UT WOS:A1993MH56800001 PM 8284049 ER PT J AU YU, FTS PAN, K UANG, CM RUFFIN, PB AF YU, FTS PAN, K UANG, CM RUFFIN, PB TI FIBER SPECKLEGRAM SENSING BY MEANS OF AN ADAPTIVE JOINT TRANSFORM CORRELATOR SO OPTICAL ENGINEERING LA English DT Article DE FIBER SPECKLEGRAMS; JOINT TRANSFORM CORRELATORS; FIBER SENSORS; TEMPERATURE MEASUREMENT; DISPLACEMENT MEASUREMENT; MICROCOMPUTER ID LIQUID-CRYSTAL TELEVISION; TRACKING AB An adaptive joint transform correlator is used to process the speckle fields derived from a multimode optical fiber. The system is applied to evaluate changes in the speckle field when the fiber is used as a sensor element. We experimentally demonstrate that the sensitivity for temperature measurement and for submicrometer displacement measurement can be as high as 0.1 degrees C and 0.2 mu m, respectively. The duty cycle of the proposed fiber sensing system is about 2.5 s, which is limited by the microcomputer that we have used. To extend the dynamic range of sensing measurement, an updated algorithm can be used, by which the dynamic range of sensing capability can be further extended. C1 USA,MISSILE COMMAND,REDSTONE ARSENAL,AL 35898. RP YU, FTS (reprint author), PENN STATE UNIV,DEPT ELECT & COMP ENGN,UNIV PK,PA 16802, USA. NR 10 TC 10 Z9 10 U1 0 U2 0 PU SOC PHOTO-OPT INSTRUM ENG PI BELLINGHAM PA PO BOX 10, BELLINGHAM, WA 98227-0010 SN 0091-3286 J9 OPT ENG JI Opt. Eng. PD NOV PY 1993 VL 32 IS 11 BP 2884 EP 2889 DI 10.1117/12.147713 PG 6 WC Optics SC Optics GA MG773 UT WOS:A1993MG77300034 ER PT J AU BALACHANDAR, S YUEN, DA REUTELER, D AF BALACHANDAR, S YUEN, DA REUTELER, D TI VISCOUS AND ADIABATIC HEATING EFFECTS IN 3-DIMENSIONAL COMPRESSIBLE CONVECTION AT INFINITE PRANDTL NUMBER SO PHYSICS OF FLUIDS A-FLUID DYNAMICS LA English DT Article ID DEPENDENT THERMAL EXPANSIVITY; MANTLE CONVECTION; FLUID; INSTABILITIES; ANOMALIES; PRESSURE; FLOWS AB A three-dimensional direct numerical simulation (using a fully spectral method) of compressible convection of an infinite Prandtl number fluid in a wide box with dimensions 5 x 5 x 1 was conducted. Depth-dependent viscosity, thermal expansivity, and thermal conductivity have been included in order to model deep-seated processes in the Earth's mantle. Solutions have been obtained up to a surface Rayleigh number of 4 X 10(7). There is a remarkable contrast between the dynamics of the upper and lower boundary layers. Very few cylindrical plumes are developed at the bottom but they merge collectively to form a strong upwelling, which pulses chaotically. Viscous and adiabatic heating are found to become important at high Rayleigh numbers, larger than 10(7). These results have important implications on the thermal structure of early Earth, where there might have been dramatic effects from intense mechanical heating near the top boundary layer. C1 MINNESOTA SUPERCOMP INST,ARMY HIGH PERFORMANCE COMP RES CTR,MINNEAPOLIS,MN 55415. UNIV MINNESOTA,DEPT GEOL & GEOPHYS,MINNEAPOLIS,MN 55415. RP BALACHANDAR, S (reprint author), UNIV ILLINOIS,DEPT THEORET & APPL MECH,URBANA,IL 61801, USA. RI Balachandar, Sivaramakrishnan/E-7358-2011 NR 39 TC 23 Z9 23 U1 0 U2 1 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0899-8213 J9 PHYS FLUIDS A-FLUID PD NOV PY 1993 VL 5 IS 11 BP 2938 EP 2945 DI 10.1063/1.858702 PG 8 WC Mechanics; Physics, Fluids & Plasmas SC Mechanics; Physics GA MD642 UT WOS:A1993MD64200036 ER PT J AU MOUL, JW AF MOUL, JW TI BENIGN PROSTATIC HYPERPLASIA - NEW CONCEPTS IN THE 1990S SO POSTGRADUATE MEDICINE LA English DT Article AB Many newer treatments are now being proposed for benign prostatic hyperplasia (BPH). Although patients with mild symptoms that do not interfere with their lifestyle can be periodically observed for progression, two classes of medication are being used for those with mild to moderate symptoms: alpha-adrenergic blocking agents and androgen suppressants. In patients with severe BPH, transurethral resection of the prostate is still the standard of care in the United States, but a number of new procedures have been introduced in recent years, including balloon dilation of the prostate, laser prostatectomy, use of prostatic stents, and microwave hyperthermia. Studies of the molecular biologic events leading to the development of BPH should clarify our understanding of a condition that was once often ignored. C1 WALTER REED ARMY MED CTR,MED CORPS,WASHINGTON,DC 20307. USUHS,WRAMC,DEPT DEF RES PROGRAM,CTR PROSTATE DIS RES,BETHESDA,MD. HENRY M JACKSON FDN ADV MIL MED,ROCKVILLE,MD. RP MOUL, JW (reprint author), UNIFORMED SERV UNIV HLTH SCI,DEPT SURG,4301 JONES BRIDGE RD,BETHESDA,MD 20814, USA. NR 14 TC 6 Z9 6 U1 0 U2 0 PU MCGRAW HILL HEALTHCARE PUBLICATIONS PI MINNEAPOLIS PA 4530 WEST 77TH ST, MINNEAPOLIS, MN 55435-5000 SN 0032-5481 J9 POSTGRAD MED JI Postgrad. Med. PD NOV 1 PY 1993 VL 94 IS 6 BP 141 EP & PG 0 WC Medicine, General & Internal SC General & Internal Medicine GA MG369 UT WOS:A1993MG36900011 PM 7694269 ER PT J AU SHOWALTER, PE YOUNG, SA BILELLO, JF SCHAFER, TW SHAVER, TR AF SHOWALTER, PE YOUNG, SA BILELLO, JF SCHAFER, TW SHAVER, TR TI ELECTROCONVULSIVE-THERAPY FOR DEPRESSION IN A LIVER-TRANSPLANT PATIENT SO PSYCHOSOMATICS LA English DT Letter C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. RP SHOWALTER, PE (reprint author), LEHIGH VALLEY HOSP,ALLENTOWN,PA 18102, USA. NR 4 TC 4 Z9 4 U1 0 U2 0 PU AMER PSYCHIATRIC ASSOCIATION PI WASHINGTON PA 1400 K ST NW, WASHINGTON, DC 20005 SN 0033-3182 J9 PSYCHOSOMATICS JI Psychosomatics PD NOV-DEC PY 1993 VL 34 IS 6 BP 537 EP 537 PG 1 WC Psychiatry; Psychology SC Psychiatry; Psychology GA MD779 UT WOS:A1993MD77900016 PM 8284346 ER PT J AU RICHARDS, MS RITTMAN, M GILBERT, TT OPAL, SM DEBUONO, BA NEILL, RJ GEMSKI, P AF RICHARDS, MS RITTMAN, M GILBERT, TT OPAL, SM DEBUONO, BA NEILL, RJ GEMSKI, P TI INVESTIGATION OF A STAPHYLOCOCCAL FOOD POISONING OUTBREAK IN A CENTRALIZED SCHOOL LUNCH PROGRAM SO PUBLIC HEALTH REPORTS LA English DT Article ID AUREUS; STRAINS AB The trend in many communities toward centralized school lunch preparation potentially increases the risk of foodborne illness. Foods often are prepared long before serving and may be distributed to satellite schools by persons with little formal training in safe techniques of food preparation or food service. In May 1990, an outbreak of staphylococcal food poisoning occurred in elementary schools in a Rhode Island community participating in such a program. In the investigation of the outbreak, students in schools that reported cases were interviewed. Food preparation, handling, and distribution were reviewed. At School E, 662 lunches were prepared and distributed to 4 additional schools (schools A-D). Schools A and B accounted for nearly all cases of the food poisoning, with rates of 47 percent and 18 percent. Eating ham increased the risk of illness (62 percent of those consuming ham and 3 percent of those who did not, relative risk = 18.0, 95 percent confidence interval = 4.0, 313.4). Large amounts of Staphylococcus aureus were cultured, and preformed enterotoxin A was identified in leftover ham. A food handler, who tested positive for the implicated enterotoxic strain S. aureus, reported having removed the casings from two of nine warm ham rolls 48 hours prior to service. Because of improper refrigeration, prolonged handling, and inadequate reheating, the ham was held at temperatures estimated at 10-49 degrees Celsius (50-120 degrees Fahrenheit) for a minimum of 15 hours. The potential for larger outbreaks prompted a statewide training program in safe food preparation for school lunch personnel, which may have applications for other communities. C1 RHODE ISL DEPT HLTH,DIV DIS PREVENT & CONTROL,PROVIDENCE,RI 02908. CTR DIS CONTROL & PREVENT,EPIDEM INTELLIGENCE SERV,DIV FIELD EPIDEMIOL,ATLANTA,GA. RHODE ISL DEPT HLTH,DDPC,OFF COMMUNICABLE DIS,PROVIDENCE,RI. MEM HOSP RHODE ISL,DIV INFECT DIS,PAWTUCKET,RI. WALTER REED ARMY INST RES,DEPT MOLEC PATHOL,WASHINGTON,DC. NR 13 TC 17 Z9 18 U1 0 U2 2 PU US GOVERNMENT PRINTING OFFICE PI WASHINGTON PA SUPT OF DOCUMENTS, WASHINGTON, DC 20402-9325 SN 0033-3549 J9 PUBLIC HEALTH REP JI Public Health Rep. PD NOV-DEC PY 1993 VL 108 IS 6 BP 765 EP 771 PG 7 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA MQ012 UT WOS:A1993MQ01200013 PM 8265762 ER PT J AU HANSEN, RC LIBELO, LF AF HANSEN, RC LIBELO, LF TI NEAR-FIELD PATTERNS OF CIRCULAR APERTURE ANTENNAS SO RADIO SCIENCE LA English DT Article; Proceedings Paper CT 1992 URSI International Symposium on Electromagnetic Theory CY AUG 17-20, 1992 CL SYDNEY, AUSTRALIA SP INT UNION RADIO SCI, COMMONWEALTH SCI & IND RES ORG, DIV RADIOPHYS AB An accurate representation of circular aperture near fields, including those in the projected aperture region, is obtained through a modification of the geometrical theory of diffraction launching coefficient. C1 USA RES LAB,ADELPHI,MD 20783. RP HANSEN, RC (reprint author), CONSULTING ENGN,POB 570215,TARZANA,CA 91357, USA. NR 8 TC 0 Z9 0 U1 0 U2 0 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 SN 0048-6604 J9 RADIO SCI JI Radio Sci. PD NOV-DEC PY 1993 VL 28 IS 6 BP 1253 EP 1258 DI 10.1029/93RS02119 PG 6 WC Astronomy & Astrophysics; Geochemistry & Geophysics; Meteorology & Atmospheric Sciences; Remote Sensing; Telecommunications SC Astronomy & Astrophysics; Geochemistry & Geophysics; Meteorology & Atmospheric Sciences; Remote Sensing; Telecommunications GA ML354 UT WOS:A1993ML35400028 ER PT J AU STANLEY, AE GODBEY, SE BONICAMP, JM LUDWICK, LM AF STANLEY, AE GODBEY, SE BONICAMP, JM LUDWICK, LM TI SPECTROCHEMICAL ANALYSIS OF THE LASER-INDUCED NITRATION OF 3 CYCLOALKANES SO SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY LA English DT Article ID RAMAN-SPECTRA AB The tunable continuous wave carbon dioxide laser-induced reactions of cyclopropane, cyclobutane and cyclopentane with NO2 have been carried out under a variety of reaction conditions. Presented herein is our qualitative Fourier transform infrared spectroscopy and gas chromatography-mass spectroscopy spectro-chemical analysis of the product mixtures. Optimal conditions were found for producing nitrocycloalkanes while reducing or eliminating the production of undesirable products. The array of products was found to be highly sensitive to the specific reaction conditions. C1 EASTERN KENTUCKY UNIV,DEPT CHEM,RICHMOND,KY 40475. MIDDLE TENNESSEE STATE UNIV,DEPT CHEM & PHYS,MURFREESBORO,TN 37132. TUSKEGEE UNIV,TUSKEGEE,AL 36088. RP STANLEY, AE (reprint author), USA,MISSILE COMMAND,CTR RES DEV & ENGN,AMSMI,RD,WS,CM,WEAP SCI DIRECTORATE,REDSTONE ARSENAL,AL 35898, USA. NR 14 TC 3 Z9 3 U1 1 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0584-8539 J9 SPECTROCHIM ACTA A JI Spectroc. Acta Pt. A-Molec. Biomolec. Spectr. PD NOV-DEC PY 1993 VL 49 IS 13-14 BP 1987 EP 1998 PG 12 WC Spectroscopy SC Spectroscopy GA ML447 UT WOS:A1993ML44700009 ER PT J AU BRODINE, SK KAIME, EM ROBERTS, C TURNICKY, RP LAL, RB AF BRODINE, SK KAIME, EM ROBERTS, C TURNICKY, RP LAL, RB TI SIMULTANEOUS CONFIRMATION AND DIFFERENTIATION OF HUMAN T-LYMPHOTROPIC VIRUS TYPE-I AND TYPE-II INFECTION BY MODIFIED WESTERN-BLOT CONTAINING RECOMBINANT ENVELOPE GLYCOPROTEINS SO TRANSFUSION LA English DT Article ID ANTIBODY REACTIVITY; IMMUNOBLOT; EPITOPES; DISEASE; DONORS; UNIQUE AB A modified Western blot (WB) that includes both shared (r21e) and unique recombinant envelope proteins from human T-lymphotropic virus (HTLV) type I (rgp46(I)) and type II (rgp46(II)) was compared to conventional HTLV serologic tests in 379 United States blood donors and individuals residing in diverse geographic regions, and the specimens were categorized as positive (n = 158), indeterminate (n = 158), or negative (n = 63) for HTLV infection. Of the 158 HTLV-I/II-positive specimens (66 requiring radioimmunoprecipitation assay [RIPA] for confirmation), 156 reacted concordantly with r21e, gag, and either rgp46(I) or rgp46(II), thus eliminating the need for RIPA in all but two specimens and yielding a test sensitivity of 98.7 percent. Of the 158 indeterminate and 63 negative specimens, none reacted with r21e and rgp46(I) or rgp46(II), yielding a test specificity of 100 percent. Furthermore, analysis of an additional 184 consecutive specimens from a retrovirology reference laboratory demonstrated that the modified WB correctly identified 27 of 28 HTLV-I specimens and, all 13 HTLV-II specimens, with a test sensitivity of 97.6 percent. None of specimens that were indeterminate or nonreactive in conventional WB and/or RIPA and none-of the screening enzyme immunoassay-negative specimens reacted with r21e and either rgp46(I) or rgp46(II), for a, test specificity of 100 percent. Thus, the modified WB appears to be highly sensitive arid specific for simultaneous detection and discrimination of HTLV-I from HTLV-II and has the advantage of being a one-step assay that is easily performed in all types of laboratory settings and allows rapid, reliable, and standardized testing for HTLV-I/II infection. C1 CTR DIS CONTROL,CTR INFECT DIS,DIV VIRAL & RICKETTSIAL DIS,RETROVIRUS DIS BRANCH,ATLANTA,GA 30333. USN,HLTH RES CTR,DEPT HLTH SCI & EPIDEMIOL,DIV EPIDEMIOL,SAN DIEGO,CA. USN HOSP,DEPT INTERNAL MED,DIV HEMATOL ONCOL,SAN DIEGO,CA 92134. WALTER REED ARMY INST RES,DEPT DIAGNOST RETROVIROL,WASHINGTON,DC. NR 20 TC 28 Z9 28 U1 0 U2 0 PU AMER ASSOC BLOOD BANKS PI BETHESDA PA 8101 GLENBROOK RD, BETHESDA, MD 20814-2749 SN 0041-1132 J9 TRANSFUSION JI Transfusion PD NOV-DEC PY 1993 VL 33 IS 11 BP 925 EP 929 DI 10.1046/j.1537-2995.1993.331194082384.x PG 5 WC Hematology SC Hematology GA MM278 UT WOS:A1993MM27800009 PM 7903127 ER PT J AU MOREY, AF DESHON, GE DRESNER, ML AF MOREY, AF DESHON, GE DRESNER, ML TI ADAPTATION OF FOLEY CATHETER FOR HEMOSTASIS DURING UROLOGIC LAPAROSCOPY SO UROLOGY LA English DT Article AB A simple, practical, rapid, and effective technique for obtaining hemostasis during urologic laparoscopy is presented. C1 TRIPLER ARMY MED CTR,DEPT SURG,UROL SERV,HONOLULU,HI 96859. NR 4 TC 0 Z9 0 U1 0 U2 0 PU CAHNERS PUBL CO PI NEW YORK PA 249 WEST 17 STREET, NEW YORK, NY 10011 SN 0090-4295 J9 UROLOGY JI UROLOGY PD NOV PY 1993 VL 42 IS 5 BP 583 EP 584 DI 10.1016/0090-4295(93)90281-E PG 2 WC Urology & Nephrology SC Urology & Nephrology GA MG849 UT WOS:A1993MG84900025 PM 8236604 ER PT J AU SCHENKMAN, NS MOUL, JW NICELY, ER MAGGIO, MI HO, CK AF SCHENKMAN, NS MOUL, JW NICELY, ER MAGGIO, MI HO, CK TI SYNCHRONOUS BILATERAL TESTIS TUMOR - MIXED GERM-CELL AND THECA CELL TUMORS SO UROLOGY LA English DT Note ID LEIOMYOMA AB Synchronous bilateral testis tumors of different histologic types are rare. All previous cases have demonstrated germ cell tumors on both sides. The simultaneous appearance of a germ cell tumor and a contralateral non-germ cell tumor has not been reported. We herein report a thirty-four-year-old man who presented with a mixed nonseminomatous germ cell tumor of the left testis and theca cell tumor of the right testis. C1 UNIFORMED SERV UNIV HLTH SCI,DEPT SURG,4301 JONES BRIDGE RD,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,UROL & PATHOL SERV,WASHINGTON,DC 20307. NR 13 TC 7 Z9 9 U1 0 U2 2 PU CAHNERS PUBL CO PI NEW YORK PA 249 WEST 17 STREET, NEW YORK, NY 10011 SN 0090-4295 J9 UROLOGY JI UROLOGY PD NOV PY 1993 VL 42 IS 5 BP 593 EP 595 DI 10.1016/0090-4295(93)90286-J PG 3 WC Urology & Nephrology SC Urology & Nephrology GA MG849 UT WOS:A1993MG84900030 PM 8236607 ER PT J AU TOBER, RL BAHDER, TB AF TOBER, RL BAHDER, TB TI DETERMINING THE ELECTRIC-FIELD IN [111] STRAINED-LAYER QUANTUM-WELLS SO APPLIED PHYSICS LETTERS LA English DT Article ID ZINCBLENDE CRYSTALS AB The electric field in a [111] growth-axis strained-layer quantum well embedded in a p-i-n diode is determined by measuring the polarzation vector in the quantum well. The polarization is determined from the critical reverse bias necessary to produce zero electric field in the quantum well. The critical reverse bias is obtained from electroreflectance spectra, which have quantum well optical features that exhibit a 180-degrees phase change at flat band. A depletion model of the p-i-n diode with an embedded quantum well is used to relate the electric field in the quantum well to the applied bias and the polarization vector in the well. RP TOBER, RL (reprint author), USA,RES LAB,2800 POWDER MILL RD,ADELPHI,MD 20783, USA. NR 10 TC 45 Z9 45 U1 0 U2 2 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD OCT 25 PY 1993 VL 63 IS 17 BP 2369 EP 2371 DI 10.1063/1.110478 PG 3 WC Physics, Applied SC Physics GA MD959 UT WOS:A1993MD95900021 ER PT J AU BRODKIN, JS SENGUPTA, LC FRANZEN, W SAGALYN, PL AF BRODKIN, JS SENGUPTA, LC FRANZEN, W SAGALYN, PL TI SURFACE CHARACTERIZATION OF METAL PLATES EXPOSED TO ATOMIC OXYGEN IN-SPACE SO THIN SOLID FILMS LA English DT Article AB The oxides formed on plates of Al, Cu, Ni, Ta, Zr and Si by exposure to atomic oxygen in space on NASA's (National Aeronautics and Space Administration) Long Duration Exposure Facility have been examined using variable angle spectroscopic ellipsometry, X-ray photoelectron spectroscopy, Fourier transform infrared spectroscopy, and Rutherford backscattering spectroscopy. A portion of each metallic specimen was shielded from direct exposure to space by an aluminum bar, and both the shielded and exposed regions of each sample were analyzed. Characterization of the metal samples revealed the stoichiometry, film thickness, and degree of porosity of the surface oxide layer for each material. The oxide films on the exposed regions of the metal samples were as thin as 354 angstrom for Ni and as thick as 1221 angstrom for Si. The shielded portions of each plate were covered by a very thin non-porous oxide film, except in the case of Cu which was thick and highly porous. The porosity of the oxide films on the exposed regions of the samples was found to be negligible in the case of Si and Al and as high as 81% porous for the Zr sample. RP BRODKIN, JS (reprint author), USA,RES LAB,MAT DIRECTORATE,MET RES BRANCH,ARSENAL ST,WATERTOWN,MA 02172, USA. NR 9 TC 6 Z9 6 U1 0 U2 0 PU ELSEVIER SCIENCE SA LAUSANNE PI LAUSANNE 1 PA PO BOX 564, 1001 LAUSANNE 1, SWITZERLAND SN 0040-6090 J9 THIN SOLID FILMS JI Thin Solid Films PD OCT 25 PY 1993 VL 234 IS 1-2 BP 512 EP 517 DI 10.1016/0040-6090(93)90320-O PG 6 WC Materials Science, Multidisciplinary; Materials Science, Coatings & Films; Physics, Applied; Physics, Condensed Matter SC Materials Science; Physics GA MD341 UT WOS:A1993MD34100046 ER PT J AU WINSLOW, RL VARGHESE, A NOBLE, D ADLAKHA, C HOYTHYA, A AF WINSLOW, RL VARGHESE, A NOBLE, D ADLAKHA, C HOYTHYA, A TI GENERATION AND PROPAGATION OF ECTOPIC BEATS INDUCED BY SPATIALLY LOCALIZED NA-K PUMP INHIBITION IN ATRIAL NETWORK MODELS SO PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES LA English DT Article ID TRANSIENT INWARD CURRENT; CALCIUM-CONCENTRATION; INTRACELLULAR SODIUM; PURKINJE-FIBERS; FERRET HEARTS; RAT-HEART; REPOLARIZATION; MECHANISMS; ISCHEMIA; RABBIT AB A biophysically detailed two-dimensional network model of the cardiac atrium has been implemented on the Thinking Machines massively parallel CM-5 supercomputer. The model is used to study the effects of spatially localized inhibition of the Na-K pump. Na overloading produced by pump inhibition can induce spontaneous, propagating ectopic beats within the network. At a cell-to-cell coupling value yielding a realistic plane wave conduction velocity of 0.6 m s(-1), pump inhibition in roughly 1000 cells can induce propagating ectopic beats in a 512 x 512 lattice of cells. C1 UNIV MINNESOTA, ARMY HIGH PERFORMANCE COMP RES CTR, MINNEAPOLIS, MN 55455 USA. UNIV OXFORD, PHYSIOL LAB, OXFORD OX1 3PJ, OXON, ENGLAND. MIT, DEPT ELECT ENGN, CAMBRIDGE, MA 02139 USA. RP WINSLOW, RL (reprint author), JOHNS HOPKINS UNIV, SCH MED, DEPT BIOMED ENGN, TRAYLOR RES BLDG, BALTIMORE, MD 21205 USA. FU Wellcome Trust NR 22 TC 56 Z9 56 U1 0 U2 0 PU ROYAL SOC PI LONDON PA 6-9 CARLTON HOUSE TERRACE, LONDON SW1Y 5AG, ENGLAND SN 0962-8452 J9 P ROY SOC B-BIOL SCI JI Proc. R. Soc. B-Biol. Sci. PD OCT 22 PY 1993 VL 254 IS 1339 BP 55 EP 61 DI 10.1098/rspb.1993.0126 PG 7 WC Biology; Ecology; Evolutionary Biology SC Life Sciences & Biomedicine - Other Topics; Environmental Sciences & Ecology; Evolutionary Biology GA ME219 UT WOS:A1993ME21900009 PM 8265676 ER PT J AU ANDREWS, LC MILLER, WB RICKLIN, JC AF ANDREWS, LC MILLER, WB RICKLIN, JC TI GEOMETRICAL REPRESENTATION OF GAUSSIAN BEAMS PROPAGATING THROUGH COMPLEX PARAXIAL OPTICAL-SYSTEMS SO APPLIED OPTICS LA English DT Article ID WAVE-PROPAGATION AB Geometric relations are used to study the propagation environment of a Gaussian beam wave propagating through a complex paraxial optical system characterized by an ABCD ray matrix in two naturally linked complex planes. In the plane defined by beam transmitter parameters OMEGA0 and OMEGA, the propagation path is described by a ray line similar to the ray line in the yyBAR diagram method, whereas the path in the plane of beam receiver parameters THETA and LAMBDA is described by a circular arc. In either plane the amplitude, phase, spot size, and radius of curvature of the Gaussian beam are directly related to the modulus and argument of the complex number designating a particular transverse plane along the propagation path. These beam parameters also lead to simple geometric relations for locating the beam waist, Rayleigh range, focal plane, and sister planes, which share the same radius of curvature but have opposite signs. Combined with the paraxial wave propagation technique based on a Huygens-Fresnel integral and complex ABCD ray matrices, this geometric approach provides a new and powerful method for the analysis and design of laser systems. C1 USA, RES LAB, BATTLEFIELD ENVIRONM DIRECTORATE, WHITE SANDS MISSILE RANGE, NM 88002 USA. RP ANDREWS, LC (reprint author), UNIV CENT FLORIDA, DEPT MATH, ORLANDO, FL 32816 USA. NR 19 TC 19 Z9 20 U1 0 U2 1 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 0003-6935 J9 APPL OPTICS JI Appl. Optics PD OCT 20 PY 1993 VL 32 IS 30 BP 5918 EP 5929 PG 12 WC Optics SC Optics GA MC053 UT WOS:A1993MC05300009 PM 20856413 ER PT J AU LINDBERG, JD DOUGLASS, RE GARVEY, DM AF LINDBERG, JD DOUGLASS, RE GARVEY, DM TI CARBON AND THE OPTICAL-PROPERTIES OF ATMOSPHERIC DUST SO APPLIED OPTICS LA English DT Article AB Atmospheric particulate matter was examined to estimate the significance of free carbon as an absorber of near-ultraviolet, visible, and near-infrared radiation. Bulk and size-fractionated samples have been disassembled into acetone-soluble, water-soluble, and insoluble fractions. The absorption coefficients for these fractions, and for the insoluble material after removal of the free carbon by burning, have been measured. The results show that in the visible and near infrared, free carbon, although not a major component by mass, is by far the dominant absorbing material. These measurements in relation to other research suggest that geographic variations in and anthropogenic contributions to the free-carbon content cause much of the variation in the absorption coefficient of atmospheric particulate samples. C1 USA, ATMOSPHER SCI LAB, WHITE SANDS MISSILE RANGE, NM 88002 USA. RP LINDBERG, JD (reprint author), SCI & TECHNOL CORP, POB 7390, HAMPTON, VA 23666 USA. NR 12 TC 30 Z9 31 U1 0 U2 2 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 0003-6935 J9 APPL OPTICS JI Appl. Optics PD OCT 20 PY 1993 VL 32 IS 30 BP 6077 EP 6081 PG 5 WC Optics SC Optics GA MC053 UT WOS:A1993MC05300031 PM 20856435 ER PT J AU VELANOVICH, V AF VELANOVICH, V TI WHY ESTIMATES OF PHYSICIAN SUPPLY AND REQUIREMENTS DISAGREE - REPLY SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Letter RP VELANOVICH, V (reprint author), USA,IRELAND COMMUNITY HOSP,FT KNOX,KY 40121, USA. NR 2 TC 1 Z9 1 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD OCT 20 PY 1993 VL 270 IS 15 BP 1814 EP 1814 DI 10.1001/jama.270.15.1814 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA MB464 UT WOS:A1993MB46400020 PM 8411523 ER PT J AU REID, TJ ALVING, BM AF REID, TJ ALVING, BM TI A QUANTITATIVE THROMBIN TIME FOR DETERMINING LEVELS OF HIRUDIN AND HIRULOG(TM) SO THROMBOSIS AND HAEMOSTASIS LA English DT Article ID RECOMBINANT DESULFATOHIRUDIN CGP-39393; ANTITHROMBOTIC ACTIVITY; EXPERIMENTAL-ANIMALS; SUBSTRATE ASSAY; HEPARIN; INHIBITION; PLASMA; ANGIOPLASTY; COMPLEX; AGENT AB The anticoagulant effect of recombinant hirudin (rHir) and Hirulog(TM) has been monitored in patients with the activated partial thromboplastin time. Accurate monitoring with this test cannot be achieved if plasmas contain heparin, lupus anticoagulants, low concentrations of fibrinogen or other factors, or elevated fibrinogen-fibrin degradation products (FDP). We have therefore developed a simple, rapid, sensitive clot-based method, the quantitative thrombin time (QTT), to measure levels of rHir and Hirulog(TM) in patient plasma (or whole blood). The QTT is performed by mixing a 1:10 dilution of patient plasma (50 mul) with human fibrinogen (50 mul, 128 mg/dl) at 37-degrees-C; the clotting time is initiated by adding human thrombin (50 mul, 5-7.5 U/ml). The concentration of Hirulog(TM) or rHir in plasma can be determined by comparing the QTT in patient plasma with a standard curve that is generated by adding different concentrations of anticoagulant to pooled normal plasma. Studies with whole blood using the same procedure yield similar results. In the absence of Hirulog(TM) or rHir, the baseline QTT is the same in normal and abnormal plasmas (fibrinogen <150 mg/dl and FDP as high as 1024 mug/ml, elevated FDP alone, lupus anticoagulant, or heparin <0.9 U/ml). When known concentrations of either rHir or Hirulog(TM) are added to abnormal plasmas, the mean observed concentrations as determined by the QTT deviate from the expected values by less than 10% (range 0-19%). The data indicate that the QTT is a simple, rapid, and accurate test for the determination of levels of rHir and Hirulog(TM) in plasma or whole blood. RP REID, TJ (reprint author), WALTER REED ARMY INST RES,DEPT HEMATOL,WASHINGTON,DC 20307, USA. NR 46 TC 22 Z9 22 U1 0 U2 1 PU F K SCHATTAUER VERLAG GMBH PI STUTTGART PA P O BOX 10 45 45, LENZHALDE 3, D-70040 STUTTGART, GERMANY SN 0340-6245 J9 THROMB HAEMOSTASIS JI Thromb. Haemost. PD OCT 18 PY 1993 VL 70 IS 4 BP 608 EP 616 PG 9 WC Hematology; Peripheral Vascular Disease SC Hematology; Cardiovascular System & Cardiology GA MD218 UT WOS:A1993MD21800014 PM 8115987 ER PT J AU GARRITY, JA HERMAN, DC IMES, R FRIES, P HUGHES, CF CAMPBELL, RJ AF GARRITY, JA HERMAN, DC IMES, R FRIES, P HUGHES, CF CAMPBELL, RJ TI OPTIC-NERVE SHEATH DECOMPRESSION FOR VISUAL-LOSS IN PATIENTS WITH ACQUIRED-IMMUNODEFICIENCY-SYNDROME AND CRYPTOCOCCAL MENINGITIS WITH PAPILLEDEMA SO AMERICAN JOURNAL OF OPHTHALMOLOGY LA English DT Article ID IMMUNE-DEFICIENCY-SYNDROME; PSEUDOTUMOR CEREBRI; VENTRICULOPERITONEAL SHUNT; AIDS; HYDROCEPHALUS; NEUROPATHY; DISEASE AB Visual dysfunction developing in association with acquired immunodeficiency syndrome (AIDS) can be multifactorial. Two patients with this syndrome and cryptococcal meningitis had papilledema and visual loss. Both were treated by optic nerve sheath fenestration. One patient had bilateral nonsimultaneous optic nerve sheath fenestrations; visual function improved in one eye. The other patient had bilateral visual improvement after a unilateral optic nerve sheath fenestration. Cryptococcal organisms were present in the dural sheath specimens of both patients despite ongoing therapy with antifungal medication. Postoperative orbital infectious complications did not occur. Autopsy examination of one patient showed that the sites of fenestration were patent. Medical treatment of cryptococcal meningitis associated with AIDS has a guarded prognosis. Optic nerve sheath fenestration offers a treatment alternative for papilledema and visual loss that occur with cryptococcal meningitis. C1 MAYO CLIN & MAYO FDN,DIV INFECT DIS & INTERNAL MED,ROCHESTER,MN 55905. OAKLAND NAVAL HOSP,DEPT OPHTHALMOL,OAKLAND,CA. LETTERMAN US ARMY HOSP,DEPT OPHTHALMOL,SAN FRANCISCO,CA. RP GARRITY, JA (reprint author), MAYO CLIN & MAYO FDN,DEPT OPHTHALMOL,200 1ST ST SW,ROCHESTER,MN 55905, USA. NR 24 TC 23 Z9 23 U1 0 U2 0 PU OPHTHALMIC PUBL CO PI CHICAGO PA 77 WEST WACKER DR, STE 660, CHICAGO, IL 60601 SN 0002-9394 J9 AM J OPHTHALMOL JI Am. J. Ophthalmol. PD OCT 15 PY 1993 VL 116 IS 4 BP 472 EP 478 PG 7 WC Ophthalmology SC Ophthalmology GA MA971 UT WOS:A1993MA97100013 PM 8213978 ER PT J AU LEGGETT, DC AF LEGGETT, DC TI MODELING SOLVENT-EXTRACTION USING THE SOLVATOCHROMIC PARAMETER-ALPHA, PARAMETER-BETA, AND PARAMETER-PI SO ANALYTICAL CHEMISTRY LA English DT Article ID SOLVATION ENERGY RELATIONSHIPS; ORGANIC SOLUTES; PARTITION-COEFFICIENTS; WATER AB A linear solvation energy relationship (LSER) employing only the solvatochromic parameters alpha, beta, pi*, and delta was shown to be adequate for describing solvent/water distribution processes for single solutes. Cavity formation is represented by the solvent alphabeta or alphabeta and pi*2. Examples of its application are given for dimethyl methylphosphonate, phenol, aniline, and acetylacetone. This kind of model could, in principle, be used by analytical chemists and chemical engineers to design and optimize solvent extraction processes. RP LEGGETT, DC (reprint author), USA,COLD REG RES & ENGN LAB,GEOCHEM SCI BRANCH,HANOVER,NH 03755, USA. NR 13 TC 41 Z9 41 U1 1 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0003-2700 J9 ANAL CHEM JI Anal. Chem. PD OCT 15 PY 1993 VL 65 IS 20 BP 2907 EP 2909 DI 10.1021/ac00068a032 PG 3 WC Chemistry, Analytical SC Chemistry GA MC047 UT WOS:A1993MC04700034 ER PT J AU BOLAN, CD KRISHNAMURTI, C TANG, DB CARRINGTON, LR ALVING, BM AF BOLAN, CD KRISHNAMURTI, C TANG, DB CARRINGTON, LR ALVING, BM TI ASSOCIATION OF PROTEIN-S DEFICIENCY WITH THROMBOSIS IN A KINDRED WITH INCREASED LEVELS OF PLASMINOGEN-ACTIVATOR INHIBITOR-1 SO ANNALS OF INTERNAL MEDICINE LA English DT Article DE PLASMINOGEN ACTIVATOR INHIBITOR-1; PROTEIN-S; THROMBOSIS; PROTEIN DEFICIENCY; HEREDITARY DISEASES ID FAST-ACTING INHIBITOR; DEEP-VEIN THROMBOSIS; VENOUS THROMBOSIS; THROMBOEMBOLIC DISEASE; FIBRINOLYTIC-ACTIVITY; C4B-BINDING PROTEIN; HUMAN-PLASMA; FAMILY; RELEASE; ASSAY AB Objective: A single kindred in North America with venous thrombosis was described as having defective fibrinolysis because of increased levels of plasminogen activator inhibitor-1 (PAI-1). Our study describes the discovery of protein S deficiency in this kindred and its association with venous thromboembolism. Design: A family study. Setting: Community. Participants: Twenty-eight adults (ages 21 to 71 years) from three generations of the kindred; seven had a history of venous thromboembolism. Measurements: Plasma levels of total and free protein S antigen, as well as the activities of protein S, protein C, PAI-1, and antithrombin III. Results: Six of 7 persons (86%) with a history of venous thromboembolism were deficient in total and free protein S; of 21 asymptomatic members, 9 were deficient in protein S (P = 0.08). When compared with these 9 asymptomatic family members, the 6 persons with protein S deficiency and a history of thrombosis tended to smoke (P = 0.01) and to have higher triglyceride levels (P = 0.001). Overall, the mean PAI-1 activity in the 7 persons who had thrombosis was 7.9 kAU/L (AU/mL) and was 9.3 kAU/L (AU/mL) in the 21 persons who did not have thrombosis (95% CI, -9.9 to 7.0). Conclusions: In this kindred, a deficiency of total and free or functional protein S is the cause of thrombosis. Measurement of PAI-1 activity was not useful in the evaluation of familial thrombosis. The utility of the routine measurement of PAI-1 activity in the evaluation of familial thrombosis has not been established. C1 WALTER REED ARMY INST RES, DEPT BIOMETR, WASHINGTON, DC 20307 USA. WALTER REED ARMY INST RES, DEPT HEMATOL, WASHINGTON, DC 20307 USA. RP BOLAN, CD (reprint author), WALTER REED ARMY MED CTR, DEPT HEMATOL ONCOL, WARD 78, WASHINGTON, DC 20307 USA. NR 36 TC 9 Z9 9 U1 0 U2 0 PU AMER COLL PHYSICIANS PI PHILADELPHIA PA INDEPENDENCE MALL WEST 6TH AND RACE ST, PHILADELPHIA, PA 19106-1572 USA SN 0003-4819 J9 ANN INTERN MED JI Ann. Intern. Med. PD OCT 15 PY 1993 VL 119 IS 8 BP 779 EP 785 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA MB496 UT WOS:A1993MB49600002 PM 8379599 ER PT J AU ROTH, BJ YEAP, BY WILDING, G KASIMIS, B MCLEOD, D LOEHRER, PJ AF ROTH, BJ YEAP, BY WILDING, G KASIMIS, B MCLEOD, D LOEHRER, PJ TI TAXOL IN ADVANCED, HORMONE-REFRACTORY CARCINOMA OF THE PROSTATE - A PHASE-II TRIAL OF THE EASTERN-COOPERATIVE-ONCOLOGY-GROUP SO CANCER LA English DT Article DE MEDICAL ONCOLOGY; PROSTATE CANCER; HORMONE-REFRACTORY; TAXOL ID CANCER; ESTRAMUSTINE; VINBLASTINE AB Background. Recent clinical trials have documented activity for combinations of chemotherapeutic agents that target the microtubular apparatus in patients with hormone-refractory prostate cancer. Taxol has a novel antimicrotubular mechanism, acting by stabilizing polymerized tubulin. Methods. Twenty-three patients with hormone-refractory prostate cancer and bidimensionally measurable disease were treated with Taxol by 24-hour continuous infusion at 135-170 mg/M2 every 21 days for a maximum of 6 cycles. Results. Eighty-five courses of Taxol were administered to 23 patients. One patient (4.3%) experienced a partial response lasting 9 months, and four other patients with radiographically stable disease had minor reductions in the serum prostate-specific antigen (PSA) of 16-24%. Eleven patients (47.8%) had stable disease, and progressive disease developed in 9 patients (39.1%) during therapy. Median survival was 9 months. Leukopenia was the dose-limiting toxicity with 13% of patients having Grade 3 and 61% having Grade 4 toxicity, and granulocytopenic fever developed in 26%. Three patients experienced sudden cardiovascular events while participating in the study, including one patient with a nonfatal, non-Q-wave myocardial infarction that occurred during a taxol infusion, and two patients who had sudden deaths 9 days and 30 days after receiving their last taxol dose, respectively. Conclusions. In the subset of patients with hormone-refractory prostate cancer and bidimensionally measurable disease, Taxol at this dosage has only minor activity. C1 INDIANA UNIV,MED CTR,INDIANAPOLIS,IN 46204. HARVARD UNIV,SCH MED,DANA FARBER CANC INST,BOSTON,MA 02115. UNIV WISCONSIN,CTR COMPREHENS CANC,MADISON,WI 53706. NYU MED CTR,NEW YORK,NY 10016. VET ADM MED CTR,E ORANGE,NJ 07019. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. FU NCI NIH HHS [CA 49883, CA 21076, CA 23318] NR 13 TC 140 Z9 142 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0008-543X J9 CANCER JI Cancer PD OCT 15 PY 1993 VL 72 IS 8 BP 2457 EP 2460 DI 10.1002/1097-0142(19931015)72:8<2457::AID-CNCR2820720825>3.0.CO;2-Z PG 4 WC Oncology SC Oncology GA MA713 UT WOS:A1993MA71300024 PM 8104680 ER PT J AU BLOEMER, MJ MYNENI, K AF BLOEMER, MJ MYNENI, K TI ELECTROOPTIC PROPERTIES NEAR THE ABSORPTION-EDGE OF GAAS ALGAAS MULTIPLE-QUANTUM-WELL WAVE-GUIDES SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID WAVE-GUIDES; PHASE MODULATION; HETEROSTRUCTURE; ELECTROABSORPTION; DEPENDENCE; FIELD; GAP AB Measurements are reported of the electro-optic properties of multiple-quantum-well p-i-n diodes at wavelengths where the waveguide propagation losses are small, 55-110 meV below the exciton resonance. Electroabsorptive and electrorefractive properties were measured as a function of polarization and crystal propagation direction. The electroabsorption and electrorefraction data show that there is a wavelength bandwidth of approximately 25 nm where the quadratic electro-optic coefficient is large (1-7 X 10(-15) cm2/V2) and the magnitude of the electroabsorption is <0.5 dB/mm for applied fields of up to 1 X 10(5) V/cm. Compact, high-dynamic-range interferometric modulators can be realized in this wavelength band. C1 APPL RES INC,HUNTSVILLE,AL 35806. RP BLOEMER, MJ (reprint author), USA,MISSILE COMMAND,AMSMI RD WS CM,REDSTONE ARSENAL,AL 35898, USA. NR 29 TC 23 Z9 23 U1 0 U2 2 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD OCT 15 PY 1993 VL 74 IS 8 BP 4849 EP 4859 DI 10.1063/1.354314 PG 11 WC Physics, Applied SC Physics GA MC030 UT WOS:A1993MC03000006 ER PT J AU ZHAO, JH BURKE, T WEINER, M CHIN, A BALLINGALL, JM AF ZHAO, JH BURKE, T WEINER, M CHIN, A BALLINGALL, JM TI REVERSE-BIASED PERFORMANCE OF A MOLECULAR-BEAM-EPITAXIAL-GROWN ALGAAS/GAAS HIGH-POWER OPTOTHYRISTOR FOR PULSED POWER-SWITCHING APPLICATIONS SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID DYNAMIC IV CHARACTERISTICS; GAAS AB The reverse-biased performance of a molecular-beam-epitaxy-grown high-power optothyristor has been systematically characterized for pulsed power-switching applications. The device has a P+N-SI-PN+ thyristor-like structure with the bipolar junctions formed by AlGaAs. The semi-insulating (SI) GaAs used is liquid-encapsulated-Czochralski grown, undoped, and 650 mum in thickness. It is found that the reverse-biased optothyristor can be triggered by a light-emitting diode operated at 10(-5) W, and miniature semiconductor lasers can trigger the switch with 132 A current using only a 1-mm-diam optical aperture. The reverse switching di/dt and the maximum peak current are reported as a function of blocking voltage. The effects of bipolar junctions on both sides of the SI-GaAs are also reported by comparing the bulk photoconductive current with the optothyristor switched current. It is shown that a laser beam of 0.05 muJ can be used to trigger on and switch about the same current as a 0.3 muJ laser beam, suggesting the possibility of integrating miniature semiconductor lasers and the optothyristors on the same chip to form a portable, compact, high-power solid-state pulser. C1 USA,LABCOM ETD LAB,FT MONMOUTH,NJ 07703. GE CO,ELECTR LAB,SYRACUSE,NY 13221. RP ZHAO, JH (reprint author), RUTGERS UNIV,DEPT ELECT & COMP ENGN,POB 909,PISCATAWAY,NJ 08855, USA. NR 15 TC 0 Z9 0 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD OCT 15 PY 1993 VL 74 IS 8 BP 5225 EP 5230 DI 10.1063/1.354262 PG 6 WC Physics, Applied SC Physics GA MC030 UT WOS:A1993MC03000066 ER PT J AU VARGHESE, A WINSLOW, RL AF VARGHESE, A WINSLOW, RL TI DYNAMICS OF THE CALCIUM SUBSYSTEM IN CARDIAC PURKINJE-FIBERS SO PHYSICA D LA English DT Article ID SARCOPLASMIC-RETICULUM; CELLULAR OSCILLATORS; INTRACELLULAR SODIUM; ELECTRICAL-ACTIVITY; EXCITABLE CELLS; INDUCED RELEASE; MODEL; RECONSTRUCTION; BIFURCATION; MECHANISMS AB A minimal model of the dynamics of internal calcium concentration of the mammalian cardiac Purkinje fiber is examined in order to identify the cause of certain arrhythmias of the heart. The effect of inhibition of the sodium/potassium pump is modeled by an elevated value of internal sodium concentration. Effects of pump inhibition are examined at different clamp voltages. Such conditions mimic those which have been examined experimentally and which are known to cause oscillatory calcium release [W.J. Lederer, PhD thesis, Yale University, New Haven, CT (1976), 168 pp.; R.S. Kass, W.J. Lederer, R.W. Tsien and R. Weingart, J. Physiol. (London) 281 (1978) 187-208). System dynamics are investigated using numerical continuation methods. Results of these analyses predict the existence of stable periodic oscillations of internal calcium over a range of voltage-clamp values. The emergence of these oscillations depends on the intracellular sodium concentration. C1 JOHNS HOPKINS UNIV,DEPT BIOMED ENGN,BALTIMORE,MD 21218. UNIV MINNESOTA,DEPT BIOMED ENGN,MINNEAPOLIS,MN 55455. RP VARGHESE, A (reprint author), UNIV MINNESOTA,USA,HIGH PERFORMANCE COMP RES CTR,1100 WASHINGTON AVE S,MINNEAPOLIS,MN 55455, USA. NR 57 TC 11 Z9 11 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-2789 J9 PHYSICA D JI Physica D PD OCT 15 PY 1993 VL 68 IS 3-4 BP 364 EP 386 DI 10.1016/0167-2789(93)90131-J PG 23 WC Mathematics, Applied; Physics, Multidisciplinary; Physics, Mathematical SC Mathematics; Physics GA MC779 UT WOS:A1993MC77900006 ER PT J AU MAGILL, AJ SMOAK, BL AF MAGILL, AJ SMOAK, BL TI FAILURE OF MEFLOQUINE CHEMOPROPHYLAXIS FOR MALARIA IN SOMALIA SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Letter ID PLASMODIUM-FALCIPARUM; SUSCEPTIBILITY RP MAGILL, AJ (reprint author), WALTER REED ARMY INST RES,WASHINGTON,DC 20307, USA. NR 5 TC 9 Z9 9 U1 0 U2 0 PU MASS MEDICAL SOC PI BOSTON PA 10 SHATTUCK, BOSTON, MA 02115 SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD OCT 14 PY 1993 VL 329 IS 16 BP 1206 EP 1206 DI 10.1056/NEJM199310143291617 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA MA667 UT WOS:A1993MA66700032 PM 8377800 ER PT J AU KUAN, CH TSUI, DC CHOI, KK NEWMAN, PG CHANG, WH AF KUAN, CH TSUI, DC CHOI, KK NEWMAN, PG CHANG, WH TI HOT-ELECTRON DISTRIBUTION IN MULTIPLE-QUANTUM-WELL INFRARED PHOTODETECTORS SO APPLIED PHYSICS LETTERS LA English DT Article ID DARK CURRENT; GAAS; TRANSITION; ABSORPTION AB The hot-electron distribution in the GaAs/AlxGa1-xAs multiple quantum well structure of 10-mum infrared photodetectors is measured with a built-in energy analyzer at different temperatures. The distribution width is found to depend strongly on T in the T almost-equal-to 40 to 90 K range. It increases with T, reaches a maximum at around 70 K, and then decreases at higher T's. The experiment makes it possible to unambiguously identify thermally assisted tunneling as the dominant source of the dark current at 77 K. C1 USA,RES LAB,EPSD,FT MONMOUTH,NJ 07703. RP KUAN, CH (reprint author), PRINCETON UNIV,DEPT ELECT ENGN,PRINCETON,NJ 08544, USA. RI Choi, Kwong-Kit/K-9205-2013 NR 14 TC 8 Z9 8 U1 0 U2 1 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD OCT 11 PY 1993 VL 63 IS 15 BP 2091 EP 2093 DI 10.1063/1.110602 PG 3 WC Physics, Applied SC Physics GA MA977 UT WOS:A1993MA97700027 ER PT J AU CAI, DM LAI, YC WINSLOW, RL AF CAI, DM LAI, YC WINSLOW, RL TI COMPLEX DYNAMICS IN COUPLED CARDIAC-PACEMAKER CELLS SO PHYSICAL REVIEW LETTERS LA English DT Article ID CYTOSOLIC FREE CALCIUM; PERFUSED RAT-HEART; RABBIT SINUS NODE; ELECTRICAL-ACTIVITY; ATRIAL NODE; CONDUCTANCE AB We investigate the dynamics of a model of electrically coupled pacemaking cardiac sino-atrial node cells. Cell models are biophysically detailed, and include voltage-dependent membrane currents, pump-exchanger currents, and time-varying internal ion concentration changes similar to those seen in real sino-atrial node cells. It is found that at low, yet physiologically realistic coupling conductance values, complex dynamics including chaos can arise. Occurrence of these complex dynamics in coupled pacemaker cells may provide an explanation for the origin of certain cardiac arrhythmias. C1 JOHNS HOPKINS UNIV,WHITING SCH ENGN,DEPT COMP SCI,BALTIMORE,MD 21205. JOHNS HOPKINS UNIV,SCH MED,DEPT BIOMED ENGN,BALTIMORE,MD 21205. UNIV MINNESOTA,USA,HIGH PERFORMANCE COMP RES CTR,MINNEAPOLIS,MN 55455. RP CAI, DM (reprint author), UNIV MINNESOTA,BIOMED ENGN PROGRAM,MINNEAPOLIS,MN 55455, USA. NR 30 TC 19 Z9 20 U1 0 U2 0 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0031-9007 J9 PHYS REV LETT JI Phys. Rev. Lett. PD OCT 11 PY 1993 VL 71 IS 15 BP 2501 EP 2504 DI 10.1103/PhysRevLett.71.2501 PG 4 WC Physics, Multidisciplinary SC Physics GA MA962 UT WOS:A1993MA96200038 ER PT J AU BECKER, DJ BLACKWELL, D AF BECKER, DJ BLACKWELL, D TI GRAVITY AND HYDROTHERMAL MODELING OF THE ROOSEVELT HOT-SPRINGS AREA, SOUTHWESTERN UTAH SO JOURNAL OF GEOPHYSICAL RESEARCH-SOLID EARTH LA English DT Article ID SYSTEM; TEMPERATURES; CALIFORNIA; ROCKS; FLOW AB The geothermal field at Roosevelt Hot Springs, Utah, produces water at temperatures exceeding 230-degrees-C. The source of the heat for the geothermal field and the nature of the hydrothermal system have been investigated by analyses of gravity, thermal, and hydrogeologic data. A deep, cylindrically shaped, anomalous mass approximately 10-15 km in diameter is inferred to exist approximately 5 km beneath the geothermal field based on inverse modeling of a - 17 mGal gravity anomaly isolated by strike filtering. This body is assumed to be a young intrusion and the heat source for the geothermal field. The configuration of the anomalous body was used in a vertical cross-sectional model of the hydrothermal system. The results of the modeling indicate (1) the source of the fluid recharge for the field is the Mineral Mountains; (2) the age of the source of the geothermal field may be younger than 500,000 years, the age of nearby rhyolites; (3) water at high temperature may be found beneath the sedimentary basin west of the geothermal field if sufficient permeability can be found; (4) the deep body beneath the field has significant permeability, in excess of 5 x 10(-18) m2; and (5) the fault zone which acts as a conduit for upwelling thermal waters and provides the production at the field is probably bounded by low-permeability material. C1 SO METHODIST UNIV,DEPT GEOL SCI,DALLAS,TX 75275. RP BECKER, DJ (reprint author), USA,CORPS ENGINEERS,12565 W CTR RD,OMAHA,NE 68144, USA. NR 56 TC 2 Z9 2 U1 2 U2 2 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 SN 0148-0227 J9 J GEOPHYS RES-SOL EA JI J. Geophys. Res.-Solid Earth PD OCT 10 PY 1993 VL 98 IS B10 BP 17787 EP 17800 DI 10.1029/93JB01231 PG 14 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA MC439 UT WOS:A1993MC43900013 ER PT J AU WALSH, ME TAYLOR, S AF WALSH, ME TAYLOR, S TI ANALYTICAL METHOD FOR WHITE PHOSPHORUS RESIDUES IN MUNITIONS-CONTAMINATED SEDIMENTS SO ANALYTICA CHIMICA ACTA LA English DT Article DE GAS CHROMATOGRAPHY; MUNITIONS; PHOSPHORUS; SEDIMENTS ID SOIL AB An analytical method is described to determine white phosphorus (P4) in sediments contaminated by smoke munitions. Experiments were performed to promote the extraction of P4 from saturated sediment with a nonpolar solvent. P4 extraction was enhanced by adding water to form a sediment-water slurry prior to shaking with isooctane for up to 24 h. P4 was determined with a portable capillary gas chromatograph equipped with a nitrogen-phosphorus detector. A certified reporting limit of 0.88 mu g kg - 1 was estimated. RP WALSH, ME (reprint author), USA,COLD REG RES & ENGN LAB,HANOVER,NH 03755, USA. NR 9 TC 9 Z9 9 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0003-2670 J9 ANAL CHIM ACTA JI Anal. Chim. Acta PD OCT 5 PY 1993 VL 282 IS 1 BP 55 EP 61 DI 10.1016/0003-2670(93)80351-K PG 7 WC Chemistry, Analytical SC Chemistry GA MA316 UT WOS:A1993MA31600005 ER PT J AU HOSKIN, FCG STEEVES, DM WALKER, JE WOODBURY, CT AF HOSKIN, FCG STEEVES, DM WALKER, JE WOODBURY, CT TI POLYCLONAL ANTIBODY GENERATION IN RABBIT BY ADMINISTRATION OF AN ORGANOPHOSPHORUS ACID ANHYDROLASE (OPAA) FROM SQUID SO BIOCHEMICAL PHARMACOLOGY LA English DT Article AB When a nerve gas hydrolyzing enzyme [organophosphorus acid anhydrolase (OPAA), formerly DFPase] purified from squid hepatopancreas was injected into rabbits. the resulting sera (RAS) inhibited OPAA purified from either squid hepatopancreas or squid optic ganglia. The inhibition was non-competitive, with 50% inhibition at a 1:1,000 serum dilution, and with the limit of inhibition (in effect, a ''titer'') at approximately 1:10,000. This RAS did not inhibit the distinctly different OPAAs from a mammalian and two bacterial sources. The hepatopancreas-generated RAS also reacted positively to the appropriate enzyme-linked immunosorbent assay (ELISA) at a titer of 1:100,000. In marked contrast, when OPAA purified from squid optic ganglion was injected into rabbits, the resulting sera did not inhibit squid OPAA, and did not give a positive ELISA. Control sera taken from the same rabbits prior to any injection (RS) did not inhibit the OPAAs. These results show another major difference between squid type OPAAs and the OPAAs from other sources, sometimes termed ''Mazur type'' OPAAs. C1 USA,CTR RES DEV & ENGN,NATICK,MA 01760. IIT,DEPT BIOL,CHICAGO,IL 60616. NR 19 TC 6 Z9 6 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0006-2952 J9 BIOCHEM PHARMACOL JI Biochem. Pharmacol. PD OCT 5 PY 1993 VL 46 IS 7 BP 1223 EP 1227 DI 10.1016/0006-2952(93)90471-8 PG 5 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA MD261 UT WOS:A1993MD26100016 PM 8216373 ER PT J AU LUCAS, CA BENEDEK, D PANGARO, L AF LUCAS, CA BENEDEK, D PANGARO, L TI LEARNING CLIMATE AND STUDENTS ACHIEVEMENT IN A MEDICINE CLERKSHIP SO ACADEMIC MEDICINE LA English DT Letter C1 UNIFORMED SERV UNIV HLTH SCI,F EDWARD HEBERT SCH MED,DEPT MED,4301 JONES BRIDGE RD,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,DEPT PSYCHIAT,WASHINGTON,DC 20307. NR 1 TC 6 Z9 6 U1 0 U2 0 PU HANLEY & BELFUS INC PI PHILADELPHIA PA 210 S 13TH ST, PHILADELPHIA, PA 19107 SN 1040-2446 J9 ACAD MED JI Acad. Med. PD OCT PY 1993 VL 68 IS 10 BP 811 EP 812 DI 10.1097/00001888-199310000-00025 PG 2 WC Education, Scientific Disciplines; Health Care Sciences & Services SC Education & Educational Research; Health Care Sciences & Services GA MC301 UT WOS:A1993MC30100028 PM 8397620 ER PT J AU SOSIN, TP PERLIN, P TRZECIAKOWSKI, W TOBER, R AF SOSIN, TP PERLIN, P TRZECIAKOWSKI, W TOBER, R TI INTERBAND ABSORPTION IN INGAAS/GAAS QUANTUM-WELL AT HIGH HYDROSTATIC-PRESSURE SO ACTA PHYSICA POLONICA A LA English DT Article; Proceedings Paper CT 22ND INTERNATIONAL SCHOOL ON PHYSICS OF SEMICONDUCTING COMPOUNDS CY MAY 22-28, 1993 CL JASZOWIEC, POLAND SP POLISH ACAD SCI, INST PHYS, WARSAW UNIV, FAC PHYS ID GAAS; PHOTOLUMINESCENCE AB The interband absorption of strained InGaAs/GaAs multiple quantum well was studied at room temperature for pressures up to 5.5 GPa. Three absorption lines were attributed to the excitonic transitions hh1-e1, 1h1-e1 and hh2-e2. They were visible until pressure of about 5 GPa which is above the GAMMA-X crossover for this system. Pressure coefficients of the observed lines were compared with the literature data. The origin of broadening of the lines above GAMMA-X crossover is discussed. C1 USA,LAB COMMAND,ADELPHI,MD 20783. WARSAW UNIV TECHNOL,INST PHYS,PL-00662 WARSAW,POLAND. RP SOSIN, TP (reprint author), POLISH ACAD SCI,HIGH PRESSURE RES CTR,SOKOLOWSKA 29,PL-01142 WARSAW,POLAND. RI Trzeciakowski, Witold/C-4074-2013 NR 10 TC 3 Z9 3 U1 0 U2 0 PU POLISH ACAD SCIENCES INST PHYSICS PI WARSAW PA AL LOTNIKOW 32-46, 02-668 WARSAW, POLAND SN 0587-4246 J9 ACTA PHYS POL A JI Acta Phys. Pol. A PD OCT PY 1993 VL 84 IS 4 BP 749 EP 752 PG 4 WC Physics, Multidisciplinary SC Physics GA MF441 UT WOS:A1993MF44100034 ER PT J AU ALVING, CR WHITE, K CASSATT, D WHITE, WI GORDON, DM GROSS, M RICHARDS, RL KRZYCH, U MADSEN, J WASSEF, NM KOENIG, S AF ALVING, CR WHITE, K CASSATT, D WHITE, WI GORDON, DM GROSS, M RICHARDS, RL KRZYCH, U MADSEN, J WASSEF, NM KOENIG, S TI LIPOSOMES AS CARRIERS OF VACCINES - INDUCTION OF CYTOLYTIC T-LYMPHOCYTES AGAINST MALARIA AND HIV EPITOPES SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,DEPT MEMBRANE BIOCHEM,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT PY 1993 VL 9 SU 1 BP S95 EP S95 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA ME188 UT WOS:A1993ME18800074 ER PT J AU EDDY, GA LEWIS, MG MCCUTCHAN, FE BENVENISTE, RE JAHRLING, PB LAI, CY BURKE, DS SHAFFERMAN, A AF EDDY, GA LEWIS, MG MCCUTCHAN, FE BENVENISTE, RE JAHRLING, PB LAI, CY BURKE, DS SHAFFERMAN, A TI ACTIVE AND PASSIVE-IMMUNIZATION INDUCED BY ENVELOPE PEPTIDES PROTECTS RHESUS MACAQUES FROM SIV AIDS SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract C1 ISRAEL INST BIOL RES,IL-70450 NESS ZIONA,ISRAEL. WALTER REED ARMY INST RES,WASHINGTON,DC 20307. HENRY M JACKSON FDN,ROCKVILLE,MD. USAMRIID,FREDERICK,MD. NCI,VIRAL CARCINOGEN LAB,FREDERICK,MD 21701. NR 0 TC 0 Z9 0 U1 0 U2 2 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT PY 1993 VL 9 SU 1 BP S109 EP S109 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA ME188 UT WOS:A1993ME18800094 ER PT J AU GOLDENTHAL, KL CAVAGNARO, JA ALVING, CR VOGEL, FR AF GOLDENTHAL, KL CAVAGNARO, JA ALVING, CR VOGEL, FR TI SAFETY EVALUATION OF VACCINE ADJUVANTS - NATIONAL-COOPERATIVE-VACCINE-DEVELOPMENT-MEETING-WORKING-GROUP SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Article ID IMMUNOLOGICAL ADJUVANTS; CLINICAL-TRIAL; VIRUS VACCINE; INFLUENZA; IMMUNOTHERAPY; INTERFERON C1 NIAID, DIV AIDS,VACCINE RES & DEV BRANCH,SOLAR BLDG, ROOM 2B06, BETHESDA, MD 20892 USA. US FDA, CTR BIOL EVALUAT & RES, BETHESDA, MD 20892 USA. WALTER REED ARMY INST RES, DEPT MEMBRANE BIOCHEM, WASHINGTON, DC 20307 USA. NR 35 TC 24 Z9 27 U1 0 U2 0 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT PY 1993 VL 9 SU 1 BP S47 EP S51 PG 5 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA ME188 UT WOS:A1993ME18800034 ER PT J AU HOKE, CH AF HOKE, CH TI LESSONS FROM FIELD TESTING OF NON-HIV VACCINES - A FIELD TRIAL OF JAPANESE ENCEPHALITIS VACCINE IN THAILAND SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Article RP HOKE, CH (reprint author), WALTER REED ARMY INST RES,DEPT VIRUS DIS,WASHINGTON,DC 20307, USA. NR 3 TC 1 Z9 1 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT PY 1993 VL 9 SU 1 BP S161 EP S167 PG 7 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA ME188 UT WOS:A1993ME18800119 ER PT J AU LOUWAGIE, J MCCUTCHAN, F MASCOLA, J EDDY, G FRANSEN, K PEETERS, M VANDERGROEN, G BURKE, D AF LOUWAGIE, J MCCUTCHAN, F MASCOLA, J EDDY, G FRANSEN, K PEETERS, M VANDERGROEN, G BURKE, D TI GENETIC SUBTYPES OF HIV-1 SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Article ID NUCLEOTIDE-SEQUENCE AB In this study we present phylogenetic tree analysis data for 70 international human immunodeficiency virus (HIV-1) isolates. For 55 isolates the complete gag gene was cloned and sequenced. When combined with 15 previously published gag sequences, phylogenetic tree analysis revealed 6 HIV-1 genetic subtypes that appear equidistant from one another. Similar branching patterns and clustering were obtained with different tree-building algorithms and the same subtypes emerged on protein sequence comparisons. Twenty-five percent of the isolates sequenced belonged to one of the three previously unrecognized subtypes. Surprisingly, several genetic subtypes appear to enjoy an almost global geographic dispersal, although local clusters of genetically related viruses were also observed. A preliminary comparison of the in vitro neutralization titers of sera corresponding to viruses in two of the HIV-1 subtypes revealed subtype-specific neutralization with little cross-reactivity between the two groups. HIV-1 exhibits considerable genetic variation among isolates from different geographic locales. Antigenic and immunological differences among the genetic subtypes should be considered in development of vaccine candidates and planning of vaccine efficacy trials. C1 HENRY M JACKSON FDN,1500 E GUDE DR,ROCKVILLE,MD 20850. PRINCE LEOPOLD INST TROP MED,B-2000 ANTWERP,BELGIUM. WALTER REED ARMY INST RES,DIV RETROVIROL,WASHINGTON,DC 20307. NR 11 TC 14 Z9 14 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT PY 1993 VL 9 SU 1 BP S147 EP S150 PG 4 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA ME188 UT WOS:A1993ME18800114 ER PT J AU MCCUTCHAN, F LOUWAGIE, J VANDERGROEN, G PEETERS, M PIOT, P MYERS, G EDDY, G BURKE, D AF MCCUTCHAN, F LOUWAGIE, J VANDERGROEN, G PEETERS, M PIOT, P MYERS, G EDDY, G BURKE, D TI COMPARISON OF GAG AND ENV GENES FROM INTERNATIONAL HIV-1 ISOLATES PROVIDES EVIDENCE FOR MULTIPLE GEOGRAPHICALLY DISPERSED SUBTYPES SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract C1 HENRY M JACKSON FDN,RES LAB,ROCKVILLE,MD 20850. PRINCE LEOPOLD INST TROP MED,ANTWERP,BELGIUM. MIL MED CONSORTIUM APPL RETROVIRAL RES,WASHINGTON,DC. WALTER REED ARMY INST RES,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD OCT PY 1993 VL 9 SU 1 BP S98 EP S98 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA ME188 UT WOS:A1993ME18800079 ER PT J AU CANCIO, LC SABANEGH, ES THOMPSON, IM AF CANCIO, LC SABANEGH, ES THOMPSON, IM TI MANAGING THE FOLEY CATHETER SO AMERICAN FAMILY PHYSICIAN LA English DT Article AB Urethral catheterization of the bladder is a commonly performed but potentially hazardous procedure. With proper patient preparation and catheter selection, difficult catheterizations can be accomplished without injuring the patient. Complications of catheterization include infection, injury to the urethra or bladder, and catheter malfunction. Physician supervision of catheter care is essential. Most of all, prompt replacement of the urethral catheter with an alternative method of bladder drainage, such as spontaneous voiding, external condom catheterization, clean intermittent catheterization or, possibly, suprapubic catheterization, is the best way to prevent the complications of urethral catheterization. RP CANCIO, LC (reprint author), USA,BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234, USA. NR 0 TC 8 Z9 8 U1 0 U2 0 PU AMER ACAD FAMILY PHYSICIANS PI KANSAS CITY PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 SN 0002-838X J9 AM FAM PHYSICIAN JI Am. Fam. Physician PD OCT PY 1993 VL 48 IS 5 BP 829 EP 836 PG 8 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA MA612 UT WOS:A1993MA61200018 PM 8213413 ER PT J AU SPIRNAK, JP WOOD, BP AF SPIRNAK, JP WOOD, BP TI RADIOLOGICAL CASE-OF-THE-MONTH - PRESACRAL GANGLIONEUROMA SO AMERICAN JOURNAL OF DISEASES OF CHILDREN LA English DT Note C1 BROOKE ARMY MED CTR,DEPT RADIOL,FT SAM HOUSTON,TX 78234. NR 8 TC 4 Z9 4 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0002-922X J9 AM J DIS CHILD JI Am. J. Dis. Child. PD OCT PY 1993 VL 147 IS 10 BP 1119 EP 1120 PG 2 WC Pediatrics SC Pediatrics GA MA979 UT WOS:A1993MA97900022 PM 8213687 ER PT J AU VUKELJA, SJ KRISHNAN, J DIEHL, LF AF VUKELJA, SJ KRISHNAN, J DIEHL, LF TI MEAN PLATELET VOLUME IMPROVES UPON THE MEGATHROMBOCYTE INDEX BUT CANNOT REPLACE THE BLOOD FILM EXAMINATION IN THE EVALUATION OF THROMBOCYTOPENIA SO AMERICAN JOURNAL OF HEMATOLOGY LA English DT Article DE THROMBOCYTOPENIA; MEAN PLATELET VOLUME; MEGATHROMBOCYTE ID DISORDERS; SIZE; PARAMETERS; NUMBER; COUNT AB The measurement of the number of platelets larger than 3 microns (megathrombocyte index) is the first element in the evaluation of thrombocytopenia. This is currently performed by counting the number of large platelets on the peripheral blood film. The MPV (mean platelet volume) is an automated measurement of the platelet volume. This study examines the mean values, correlations, sensitivity, specificity and the receiver operating characteristic curve (comparison of two tests) to determine which of these tests better separates the production state. For increased vs. decreased production, the MPV was 10.0 + 1.9 fL and 8.0 + 1.5 fL (P < .0001) respectively and the megathrombocyte index (MEGA) was 19.0 + 17.6% and 11.5 + 14.9% (P < .007) respectively. The correlation with the state of production was better for MPV (R = .47) than for MEGA (R = .20). For the MPV a sensitivity of 80% occurred with the MPV greater-than-or-equal-to 8.4 fL with a specificity of 71%. For a MEGA greater-than-or-equal-to 6%, the sensitivity was 80% but the specificity was 43%. For any MPV the sensitivity and specificity were better than for any MEGA. The Receiver Operating Characteristic Curve demonstrated that the MPV is a better test than the MEGA for separating the production into increased and decreased states. The MPV is a better test than the MEGA and will add to, but not replace, examination of the peripheral blood film in the diagnosis of thrombocytopenia. (C) 1993 Wiley-Liss, Inc. C1 WALTER REED ARMY MED CTR,DEPT MED,HEMATOL ONCOL SERV,WASHINGTON,DC 20307. NR 20 TC 9 Z9 9 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0361-8609 J9 AM J HEMATOL JI Am. J. Hematol. PD OCT PY 1993 VL 44 IS 2 BP 89 EP 94 DI 10.1002/ajh.2830440204 PG 6 WC Hematology SC Hematology GA LV306 UT WOS:A1993LV30600003 PM 8266925 ER PT J AU CURETON, SL REGENNITTER, FJ YANCEY, JM AF CURETON, SL REGENNITTER, FJ YANCEY, JM TI THE ROLE OF THE HEADGEAR CALENDAR IN HEADGEAR COMPLIANCE SO AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS LA English DT Article ID REGIMENS AB This study was undertaken to determine the role of the headgear calendar and its relationship to headgear compliance. Headgear timers were used covertly to monitor actual headgear wear of 28 patients for three consecutive orthodontic appointments. Fourteen patients were asked to monitor their daily headgear wear by using a headgear calendar. The other 14 did not use a calendar. The results show that patients who monitor their headgear wear with a headgear calendar are more compliant than those patients who do not (7.9 hours compared with 5.3 hours). All age groups in this study wore their headgear more when a headgear calendar was used with the exception of the >16-year-old group. There is a high degree of correlation (r2 = 0.60) between the number of hours recorded on the calendar compared with the number of hours actually worn. There was a poor correlation (r2 = 0.02) between the number of hours the patient said he wore his headgear compared with the actual number of hours worn. C1 CRAVEN DENT CLIN,ADV EDUC PROGRAM ORTHODONT,FT KNOX,KY. USA,FT KNOX,KY 40121. UNIV LOUISVILLE,DEPT DIAG & GEN DENT,LOUISVILLE,KY 40292. NR 14 TC 18 Z9 18 U1 0 U2 1 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0889-5406 J9 AM J ORTHOD DENTOFAC JI Am. J. Orthod. Dentofac. Orthop. PD OCT PY 1993 VL 104 IS 4 BP 387 EP 394 DI 10.1016/S0889-5406(05)81338-1 PG 8 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA MC627 UT WOS:A1993MC62700017 PM 8213662 ER PT J AU EARLS, JP DACHMAN, AH COLON, E GARRETT, MG MOLLOY, M AF EARLS, JP DACHMAN, AH COLON, E GARRETT, MG MOLLOY, M TI PREVALENCE AND DURATION OF POSTOPERATIVE PNEUMOPERITONEUM - SENSITIVITY OF CT VS LEFT LATERAL DECUBITUS RADIOGRAPHY SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Article ID COMPUTED-TOMOGRAPHY; BOWEL PERFORATION; DIAGNOSIS AB OBJECTIVE. The purpose of this study was to evaluate the prevalence, location, and duration of pneumoperitoneum in postoperative patients and to compare the sensitivities of CT and left lateral decubitus radiography in the detection of postoperative pneumoperitoneum. SUBJECTS AND METHODS. Twenty-seven CT scans and 27 abdominal radiographs with the patient in the left lateral decubitus position were obtained prospectively in 17 patients after uncomplicated abdominal surgery. Fifteen patients were examined 3 days after surgery and 12 were examined 6 days after surgery. The studies were evaluated in a blinded fashion for the presence, location, and volume of free air. The presence of air on the radiographs and the presence and quantity of air on the CT scans were correlated with each subject's surgical procedure, age, sex, and body habitus. RESULTS. Pneumoperitoneum was seen on 13 (87%) of 15 CT scans and eight (53%) of 15 radiographs obtained 3 days after surgery and on six (50%) of 12 CT scans and one (8%) of 12 radiographs obtained 6 days after surgery. The calculated volume of free air seen on the CT scans ranged from 0.3 to 5.8 ml. Sixty-two percent of collections by volume were located in the midline/parahepatic space, 22% in the pelvis, and 16% in the mesentery. Radiographs showed pneumoperitoneum in only nine (47%) of 19 examinations in which the corresponding CT scans showed free air. Findings on radiographs were false-negative in seven (87%) of eight obese patients in whom pneumoperitoneum was detected on CT scans. CONCLUSION. The prevalence of pneumoperitoneum in the postoperative period based on CT findings is greater than that previously reported. Small amounts of pneumoperitoneum frequently collect along the anterior abdominal wall in two preferential spaces, the pararectus and midrectus recesses. The results of this study show that CT is significantly more sensitive than plain radiography for detecting small amounts of free intraperitoneal air in postoperative patients. Radiography is particularly insensitive for imaging obese and heavy patients. C1 UNIFORMED SERV UNIV HLTH SCI,DEPT RADIOL,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,DEPT SURG,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,DEPT SURG,BETHESDA,MD 20814. RP EARLS, JP (reprint author), WALTER REED ARMY MED CTR,DEPT RADIOL,WASHINGTON,DC 20307, USA. NR 16 TC 58 Z9 59 U1 0 U2 1 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR, SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 SN 0361-803X J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD OCT PY 1993 VL 161 IS 4 BP 781 EP 785 PG 5 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA MG651 UT WOS:A1993MG65100017 PM 8372757 ER PT J AU KADAKIA, SC AF KADAKIA, SC TI PEG/PEJ AND THE INCIDENCE OF ASPIRATION - RESPONSE SO AMERICAN JOURNAL OF SURGERY LA English DT Letter ID JEJUNOSTOMY; GASTROSTOMY RP KADAKIA, SC (reprint author), BROOKE ARMY MED CTR,DEPT MED,GASTROENTEROL SERV,SAN ANTONIO,TX 78234, USA. NR 5 TC 1 Z9 1 U1 0 U2 0 PU CAHNERS PUBL CO PI NEW YORK PA 249 WEST 17 STREET, NEW YORK, NY 10011 SN 0002-9610 J9 AM J SURG JI Am. J. Surg. PD OCT PY 1993 VL 166 IS 4 BP 441 EP 442 DI 10.1016/S0002-9610(05)80354-X PG 2 WC Surgery SC Surgery GA MC374 UT WOS:A1993MC37400031 ER PT J AU CORCORAN, KD HANSUKJARIYA, P SATTABONGKOT, J NGAMPOCHJANA, M EDSTEIN, MD SMITH, CD SHANKS, GD MILHOUS, WK AF CORCORAN, KD HANSUKJARIYA, P SATTABONGKOT, J NGAMPOCHJANA, M EDSTEIN, MD SMITH, CD SHANKS, GD MILHOUS, WK TI CAUSAL PROPHYLACTIC AND RADICAL CURATIVE ACTIVITY OF WR182393 (A GUANYLHYDRAZONE) AGAINST PLASMODIUM-CYNOMOLGI IN MACACA-MULATTA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID ANTIMALARIAL-DRUGS; INFECTIONS AB Primaquine is the only currently available drug effective against persistent tissue stages of relapsing malaria in humans. Causal prophylactic and radical curative properties of WR182393 (a guanylhydrazone) were investigated as part of an effort to evaluate alternatives to primaquine in the rhesus monkey (Macaca mulatta)/Plasmodium cynomolgi test model. The drug was suspended in dimethylsulfoxide for intramuscular (im) injection. A pilot study indicated causal prophylactic activity in a regimen of 40 mg base/kg/day im for three days beginning the day before intravenous challenge with 1 x 10(6) P. cynomolgi sporozoites. Regimens of 31, 10, 3. 1, and 0 mg base/kg/day im for three days were then tested in groups of two monkeys given a similar challenge. The two animals given 31 mg base/kg/day remained parasite-free. Average time to parasitemia for the lower dosage groups was 38, 18, and 8 days respectively. Groups of two monkeys with sporozoite-induced P. cynomolgi infections were also treated for seven days with 31, 10, 3. 1, and 0 mg base/kg/day im in combination with 10 mg base/kg/day of chloroquine orally. Both monkeys given 31 mg base/kg/day did not relapse. The average time to relapse following treatment was 48, 29, and 8 days, respectively, for the lower dosage groups. Compound WR182393 is the first non-8-aminoquinoline class of drug to exhibit both causal prophylactic and radical curative properties against a relapsing primate, vivax-like malaria. C1 ARMED FORCES RES INST MED SCI,DEPT VET MED,BANGKOK,THAILAND. ARMED FORCES RES INST MED SCI,DEPT MED ENTOMOL,BANGKOK,THAILAND. ARMED FORCES RES INST MED SCI,DEPT IMMUNOL & PARASITOL,BANGKOK,THAILAND. ARMED FORCES RES INST MED SCI,DEPT MED,BANGKOK,THAILAND. WALTER REED ARMY INST RES,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307. NR 7 TC 11 Z9 11 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD OCT PY 1993 VL 49 IS 4 BP 473 EP 477 PG 5 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA MD964 UT WOS:A1993MD96400012 PM 8214277 ER PT J AU KAIN, KC BROWN, AE LANAR, DE BALLOU, WR WEBSTER, HK AF KAIN, KC BROWN, AE LANAR, DE BALLOU, WR WEBSTER, HK TI RESPONSES OF PLASMODIUM-VIVAX VARIANTS TO CHLOROQUINE AS DETERMINED BY MICROSCOPY AND QUANTITATIVE POLYMERASE CHAIN-REACTION SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID IMMUNODEFICIENCY-VIRUS TYPE-1; CIRCUMSPOROZOITE PROTEIN; BLOOD; RESISTANCE AB Genotypic heterogeneity in the repetitive portion of the circumsporozoite (CS) protein of Plasmodium vivax has been reported from many P. vivax-endemic areas. The objective of this study was to determine if the VK210 and VK247 CS variants of P. vivax differed in their clearance rates following chloroquine (CQ) therapy. One hundred seventy-one cases of P. vivax infection occurring in patients presenting to a research treatment center in Thailand were analyzed. Finger-prick blood samples were collected for microscopy and spotted onto filter paper at presentation and on each of five days of observation through supervised CQ therapy. A portion of the CS gene was amplified from filter paper samples by the polymerase chain reaction (PCR) and genotyped by oligoprobes specific for the VK210 and VK247 CS repeat regions. The mean time to clear parasitemia as determined by thick blood smear was significantly longer for pure VK210 infections (51 hr; 95% confidence interval [CI] 47.4-54, P = 0.006) and mixed infections (53 hr; 95% CI 49.2-56.7, P = 0.0009) as compared with VK247 infections (44 hr; 95% CI 39.8-47.9). Five patients matched for parasitemia, age, sex, and previous malaria experience were selected from each of the three genotype groups in the larger study for further analysis by quantitative PCR of P. vivax genotype-specific DNA during a treatment course. The mean time to clear parasite DNA, as determined by PCR, was significantly slower for VK210 parasites (65 hr; 95% CI 51-79) than for VK247 parasites (47 hr; 95% CI 30-63, P = 0.045). In patients with mixed infections, VK210 DNA also cleared more slowly (mean 66 hr; 95% CI 40-93) than VK247 DNA (mean 35 hr; 95% CI 23-47, P = 0.056). These results suggest that strain-variable responses to CQ may exist. Detection and quantification of P. vivax genotype-specific DNA from filter paper samples may be useful as a method to monitor response to chemotherapy in a field setting. C1 WALTER REED ARMY INST RES, DEPT DIAGNOST RETROVIROL, WASHINGTON, DC 20307 USA. WALTER REED ARMY INST RES, DEPT IMMUNOL, WASHINGTON, DC 20307 USA. WALTER REED ARMY INST RES, DEPT EXPTL THERAPEUT, WASHINGTON, DC 20307 USA. ARMED FORCES RES INST MED SCI, DEPT IMMUNOL, BANGKOK, THAILAND. RP KAIN, KC (reprint author), TORONTO HOSP, TROP DIS UNIT, 200 ELIZABETH ST, TORONTO M5G 2C4, ON, CANADA. RI Lanar, David/B-3560-2011 NR 16 TC 26 Z9 28 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 EI 1476-1645 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD OCT PY 1993 VL 49 IS 4 BP 478 EP 484 PG 7 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA MD964 UT WOS:A1993MD96400013 PM 8214278 ER PT J AU MAENO, Y TOYOSHIMA, T FUJIOKA, H ITO, Y MESHNICK, SR BENAKIS, A MILHOUS, WK AIKAWA, M AF MAENO, Y TOYOSHIMA, T FUJIOKA, H ITO, Y MESHNICK, SR BENAKIS, A MILHOUS, WK AIKAWA, M TI MORPHOLOGIC EFFECTS OF ARTEMISININ IN PLASMODIUM-FALCIPARUM SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID QINGHAOSU; INVITRO; MALARIA; BERGHEI AB Ultrastructural changes induced in Plasmodium falciparum by artemisinin were studied in vitro. Electron microscopic autoradiography was performed on infected erythrocytes that were exposed in vitro to H-3-dihydroartemisinin and C-14-artemisinin. These drugs consistently were located in food vacuoles and mitochondria. Two hours after administration, changes were observed in parasite mitochondria, rough endoplasmic reticulum, and nuclear envelope. At four hours, in addition to the earlier changes, nuclear membranes and, to a lesser extent, some plasma membranes formed myelin figures. In addition, there was a disappearance of ribosomes, and a destruction of food vacuole membranes. These changes may lead to the total disorganization of the parasites. Approximately 30% of the parasites manifested these alterations. C1 CASE WESTERN RESERVE UNIV,INST PATHOL,2085 ADELBERT RD,CLEVELAND,OH 44106. UNIV MICHIGAN,SCH PUBL HLTH,DEPT EPIDEMIOL,ANN ARBOR,MI 48109. UNIV GENEVA,DEPT PHARMACOL,CH-1211 GENEVA 4,SWITZERLAND. WALTER REED ARMY INST RES,WALTER REED ARMY MED CTR,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307. FU NIAID NIH HHS [AI-10645, AI-26848] NR 16 TC 69 Z9 72 U1 1 U2 5 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD OCT PY 1993 VL 49 IS 4 BP 485 EP 491 PG 7 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA MD964 UT WOS:A1993MD96400014 PM 8214279 ER PT J AU SEIN, KK BROWN, AE MAENO, Y SMITH, CD CORCORAN, KD HANSUKJARIYA, P WEBSTER, HK AIKAWA, M AF SEIN, KK BROWN, AE MAENO, Y SMITH, CD CORCORAN, KD HANSUKJARIYA, P WEBSTER, HK AIKAWA, M TI SEQUESTRATION PATTERN OF PARASITIZED ERYTHROCYTES IN CEREBRUM, MID-BRAIN, AND CEREBELLUM OF PLASMODIUM-COATNEYI-INFECTED RHESUS-MONKEYS (MACACA-MULATTA) SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID TUMOR NECROSIS FACTOR; FALCIPARUM-MALARIA; ADHESION MOLECULE-1; CYTOADHERENCE; PATHOLOGY; MEMBRANE; RECEPTOR; ROLES AB Six rhesus monkeys (Macaca mulatta) infected with Plasmodium coatneyi were studied for parasitized red blood cell (PRBC) sequestration in microvessels of the brain. The degree of PRBC sequestration is different in the cerebral, mid-brain, and cerebellar microvessels, with sequestration occurring preferentially in the cerebellum. This pattern resembles that of PRBC sequestration in cerebral and cerebellar microvessels in human falciparum malaria. The morphologic appearance of sequestered cells under light and electron microscopy as well as the PRBC sequestration pattern bolsters the contention that the rhesus monkey infected with P. coatneyi is an appropriate primate model for the experimental study of human cerebral malaria. C1 CASE WESTERN RESERVE UNIV,INST PATHOL,2085 ADELBERT RD,CLEVELAND,OH 44106. WALTER REED ARMY INST RES,DIV RETROVIROL,WASHINGTON,DC 20307. ARMED FORCES RES INST MED SCI,USA MED COMPONENT,DEPT VET MED,BANGKOK,THAILAND. WALTER REED ARMY INST RES,DEPT PARASITOL,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307. FU NIAID NIH HHS [AI-10645] NR 31 TC 27 Z9 27 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD OCT PY 1993 VL 49 IS 4 BP 513 EP 519 PG 7 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA MD964 UT WOS:A1993MD96400017 PM 8214282 ER PT J AU SIROIS, JG PIMENTEL, L AF SIROIS, JG PIMENTEL, L TI PROGNOSTIC VALUE OF THE EMERGENCY DEPARTMENT FOR IN-HOSPITAL COMPLICATIONS OF ACUTE MYOCARDIAL-INFARCTION SO ANNALS OF EMERGENCY MEDICINE LA English DT Article AB Study objective: To identify patients who are admitted from the emergency department with chest discomfort who are at low risk for life-threatening complications. Design: Retrospective chart review. Setting: A 450-bed military medical center providing active duty and military beneficiaries. Type of participants: Six hundred twenty-one patients admitted to an ICU from the ED with the chief complaint of chest discomfort. Measurements and main results: Study participants were placed into low- and high-risk groups based on clinical criteria and ECGs. The groups were compared with respect to occurrence of life-threatening complications during the hospital course. Three of the 262 patients in the low-risk group experienced life-threatening events; two died. Twenty-nine of the 224 high-risk patients experienced life-threatening events; 17 died. Results were statistically evaluated using Fisher's exact test. Significance was achieved at a value of P<.01. Conclusion: Patients who meet low-risk group criteria have a low likelihood of immediate life-threatening events and could be admitted to an intermediate care unit. RP SIROIS, JG (reprint author), BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234, USA. NR 0 TC 2 Z9 2 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0196-0644 J9 ANN EMERG MED JI Ann. Emerg. Med. PD OCT PY 1993 VL 22 IS 10 BP 1568 EP 1572 DI 10.1016/S0196-0644(05)81260-0 PG 5 WC Emergency Medicine SC Emergency Medicine GA LZ645 UT WOS:A1993LZ64500010 PM 8214837 ER PT J AU GRAFF, J TICEHURST, J FLEHMIG, B AF GRAFF, J TICEHURST, J FLEHMIG, B TI DETECTION OF HEPATITIS-A VIRUS IN SEWAGE-SLUDGE BY ANTIGEN CAPTURE POLYMERASE CHAIN-REACTION SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY LA English DT Article AB Antigen capture polymerase chain reaction (PCR) was tested as a sensitive and rapid method for detecting hepatitis A virus (HAV) in raw sewage sludge. The antigen capture PCR was performed both with and without solid-phase virus-catching monoclonal antibodies. Similar results proved that both methods were equally sensitive. Sewage sludge samples from different regions in Germany were examined for evidence of HAV contamination by antigen capture PCR. This method of detection was compared with that used in a previous study of these sewage sludge samples, in which the HAV was detected through indirect immunofluorescence after cell culture inoculation. The results obtained by antigen capture PCR matched those obtained in the earlier cell culture investigations, when HAV was detected in raw as well as digested sewage sludge samples. The advantage of the PCR method, however, lies in the fact that it needs only two days while the cell culture propagation of RAV takes about 8 to 10 weeks. C1 WALTER REED ARMY INST RES,DEPT VIRUS DIS,WASHINGTON,DC 20307. RP GRAFF, J (reprint author), UNIV TUBINGEN,INST HYG,DEPT VIROL & EPIDEMIOL VIRUS DIS,W-7400 TUBINGEN 1,GERMANY. RI Ticehurst, John/I-7532-2012 NR 15 TC 57 Z9 58 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0099-2240 J9 APPL ENVIRON MICROB JI Appl. Environ. Microbiol. PD OCT PY 1993 VL 59 IS 10 BP 3165 EP 3170 PG 6 WC Biotechnology & Applied Microbiology; Microbiology SC Biotechnology & Applied Microbiology; Microbiology GA MA353 UT WOS:A1993MA35300001 PM 8250546 ER PT J AU KAVOLIUS, J GOLOCOVSKY, M CHAMPION, HR AF KAVOLIUS, J GOLOCOVSKY, M CHAMPION, HR TI PREDICTORS OF OUTCOME IN PATIENTS WHO HAVE SUSTAINED TRAUMA AND WHO UNDERGO EMERGENCY THORACOTOMY SO ARCHIVES OF SURGERY LA English DT Article ID ROOM THORACOTOMY; SURVIVAL; WOUNDS; HEART AB Objective: To reassess the use of emergency thoracotomy in resuscitating victims of abdominal or thoracic trauma. Design: Retrospective review of records and autopsy reports of patients who underwent an emergency thoracotomy between 1983 and 1989. Setting: Washington Hospital Center's Level I trauma center. Patients: Two hundred eighty-four hemodynamically unstable trauma patients (212 [75%] with penetrating injuries and 72 [25%] with blunt injuries). Intervention: Emergency thoracotomy performed in the trauma operating room or in one of the trauma bays. Main Outcome Measures and Key Findings: In which subset of trauma patients is emergency thoracotomy a useful therapeutic modality? Performance of an emergency thoracotomy for blunt trauma resulted in an overall survival rate of 6% compared with 27% for penetrating trauma. The survival rate for patients with penetrating cardiac trauma was 32% (44% for stab wounds and 21% for gunshot wounds). Tamponade is a major factor associated with survival in this subset of patients and may act as a pathophysiologic filter. Conclusions: Emergency thoracotomy is a useful therapeutic modality for victims of penetrating trauma who have vital signs on admission to the hospital, and it should be considered in blunt trauma patients who present with any evidence of life. This modality is largely ineffective, however, in resuscitating victims of penetrating and blunt trauma who present to the hospital without vital signs. C1 WASHINGTON HOSP CTR,DEPT TRAUMA & SURG CRIT CARE,TRAUMA & SURG CRIT CARE SERV,WASHINGTON,DC 20010. WOMACK ARMY MED CTR,FT BRAGG,NC. UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. WASHINGTON HOSP CTR,DEPT SURG CRIT CARE,TRAUMA SERV,WASHINGTON,DC 20010. WASHINGTON HOSP CTR,EMERGENCY SERV,WASHINGTON,DC 20010. NR 16 TC 29 Z9 32 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0004-0010 J9 ARCH SURG-CHICAGO JI Arch. Surg. PD OCT PY 1993 VL 128 IS 10 BP 1158 EP 1162 PG 5 WC Surgery SC Surgery GA MB498 UT WOS:A1993MB49800010 PM 8215876 ER PT J AU WENGER, B QUIGLEY, MD KOLKA, MA AF WENGER, B QUIGLEY, MD KOLKA, MA TI 7-DAY PYRIDOSTIGMINE ADMINISTRATION AND THERMOREGULATION DURING REST AND EXERCISE IN DRY HEAT SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article ID CHOLINESTERASE AB Seven men participated in a double-blind study of effects of multiple-dose oral pyridostigmine bromide (PB) on physiological responses to 4-h heat stress tests (HST's) in a hot dry environment, 42-degrees-C, 20% relative humidity. Subjects underwent 2 7-d series of tests, separated by 72 h, taking 30 mg PB every 8 h in one series, and placebo in the other. Each HST began right after the 0800 dose of PB or placebo. Subjects drank ad libitum during each HST, and performed two 55-min treadmill walks at about 40% VO2max during the last 2 h. Inhibition of red cell cholinesterase at the start of exercise averaged 30.0% in subjects taking PB, and did not differ significantly among HST's with PB. PB increased sweating and evaporative water loss by about 4%, and lowered chest skin temperature during exercise by 0.7-degrees-C; but it had no significant effect on rectal temperature, other skin temperatures, O2 uptake, or fluid balance. PB alone had no significant effect on heart rate (HR), but had a significant interaction with day: although PB had essentially no effect on HR in the lst HST, its effect increased progressively so that HR during exercise in the 4th HST was 8 beats . min-1 lower with PB. Multiple-dose PB had only slight effects on responses to moderate exercise-heat stress beyond those described after single-dose PB, and we found no adverse effects of multiple-dose PB administration. RP WENGER, B (reprint author), USA,ENVIRONM MED RES INST,DIV THERMAL PHYSIOL & MED,NATICK,MA 01760, USA. NR 16 TC 19 Z9 20 U1 0 U2 0 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD OCT PY 1993 VL 64 IS 10 BP 905 EP 911 PG 7 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA MA049 UT WOS:A1993MA04900004 PM 8240194 ER PT J AU YEE, E KOSTENIUK, PR CHANDLER, GM BILTOFT, CA BOWERS, JF AF YEE, E KOSTENIUK, PR CHANDLER, GM BILTOFT, CA BOWERS, JF TI RECURRENCE STATISTICS OF CONCENTRATION FLUCTUATIONS IN PLUMES WITHIN A NEAR-NEUTRAL ATMOSPHERIC SURFACE-LAYER SO BOUNDARY-LAYER METEOROLOGY LA English DT Article ID BOUNDARY-LAYER AB This study examines the statistical properties of the concentration derivative, chi', for a dispersing plume in a near-neutrally stratified atmospheric surface layer. Towards this goal, the probability density function (pdf) of chi', and the conditional pdf of chi' given a fixed concentration level, chi, have been measured. These pdfs are found to be modeled well by a generalized q-Gaussian (gqG) distribution with intermittency exponent, q, equal to 0.3 and 3/4, respectively. These results highlight the strong intermittency effect (patchiness) of the small-scale concentration eddy structures in the plume. The distribution of time intervals between successive high peaks in the squared derivative process, chi'2, is found to be we approximated by a power-law distribution, implying that occurrences of these high peaks are much more clustered than would be predicted by a Poisson or shot-noise process. The results are used to improve models for the joint pdf of chi and chi', and for the expected number of upcrossings per unit time interval of a fixed concentration level that have been proposed by Kristensen et al. (1989). The predictions of the improved models are in accord with observations, and suggest that the intercorrelation between chi and chi' must be explicitly incorporated if good estimates of the upcrossing intensity are to be obtained. C1 KOSTENIUK CONSULTING LTD,SASKATOON S7H 2L9,SK,CANADA. S&J ENGN INC,SCARBOROUGH M1V 3S1,ON,CANADA. USA,MAT TEST DIRECTORATE,DIV METEOROL,DUGWAY PROVING GROUND,UT 84022. RP YEE, E (reprint author), DEF RES ESTAB SUFFIELD,BOX 4000,MEDICINE HAT T1A 8K6,AB,CANADA. NR 22 TC 19 Z9 19 U1 0 U2 0 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 0006-8314 J9 BOUND-LAY METEOROL JI Bound.-Layer Meteor. PD OCT PY 1993 VL 66 IS 1-2 BP 127 EP 153 DI 10.1007/BF00705463 PG 27 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA LZ062 UT WOS:A1993LZ06200007 ER PT J AU MARDEN, LJ QUIGLEY, NC REDDI, AH HOLLINGER, JO AF MARDEN, LJ QUIGLEY, NC REDDI, AH HOLLINGER, JO TI TEMPORAL CHANGES DURING BONE REGENERATION IN THE CALVARIUM INDUCED BY OSTEOGENIN SO CALCIFIED TISSUE INTERNATIONAL LA English DT Article DE BONE MORPHOGENETIC PROTEIN; REPAIR; COLLAGEN ID GROWTH FACTOR-BETA; AFFINITY-CHROMATOGRAPHY; INDUCTIVE PROTEIN; MATRIX PROTEINS; DIFFERENTIATION; CELLS; DEFECTS AB Repair of rat craniotomy defects, 8 mm in diameter, was compared with that of defects treated with either rat insoluble collagenous bone matrix (ICBM) or partially purified bovine osteogenin, a bone-inductive protein, reconstituted with ICBM (OG/ICBM). Repair of all defects was similar histologically throughout the first 3 days, characterized by acute, then chronic inflammation and granulation tissue formation. In defects treated with OG/ICBM, cartilage and osteoblasts were present at day 5. By day 9, cartilage and osteoid production were active. New bone showed hematopoietic tissue by day 11; a complete bone bridge was established by day 21. By day 42, fatty marrow was present. Defects treated with ICBM alone showed islands of cartilage and bone embedded in connective tissue at day 9, which reached peak maturity by day 14. In these and in untreated defects, significant osteoblastic and osteoclastic activity, located primarily at the margins of the defects, subsided by day 28. Untreated defects gradually filed in with fibrous connective tissue which matured throughout 156 days. Radiopacity, quantified by computerized image analysis, increased significantly between days 9 and 11 in OG/ICBM-treated defects, and remained greater (P < 0.05) than that of the ICBM-treated defects. There was a more gradual increase in radiopacity in ICBM-treated defects. The sequence of morphologic events during calvarial bone regeneration was very similar to that described previously for heterotopic bone formation induced by demineralized bone matrix. C1 WALTER REED ARMY MED CTR,USA,INST DENT RES,WASHINGTON,DC 20307. JOHNS HOPKINS UNIV,SCH MED,DEPT ORTHOPAED SURG,BALTIMORE,MD 21205. NR 30 TC 19 Z9 19 U1 0 U2 0 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0171-967X J9 CALCIFIED TISSUE INT JI Calcif. Tissue Int. PD OCT PY 1993 VL 53 IS 4 BP 262 EP 268 DI 10.1007/BF01320912 PG 7 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA LX472 UT WOS:A1993LX47200009 PM 8275355 ER PT J AU LAIRD, JR HULL, R STAJDUHAR, KC WESTON, LT KUFS, W WORTHAM, DC AF LAIRD, JR HULL, R STAJDUHAR, KC WESTON, LT KUFS, W WORTHAM, DC TI TRANSCORONARY CARDIAC PACING DURING MYOCARDIAL-ISCHEMIA SO CATHETERIZATION AND CARDIOVASCULAR DIAGNOSIS LA English DT Article DE CORONARY PACING; PTCA; SEVERE BRADYARRHYTHMIAS ID LUMINAL CORONARY ANGIOPLASTY; COMPLICATIONS AB Severe bradyarrhythmias are a rare but potentially life threatening complication of percutaneous transluminal coronary angioplasty (PTCA). Previous work has outlined a technique for coronary pacing using the angioplasty guidewire. To examine the effectiveness of this technique during severe ischemia, seven swine underwent placement of an unmodified 0.014 inch angioplasty guidewire and 3.0 mm balloon catheter in the left anterior descending (LAD) artery. Baseline pacing thresholds were obtained. Pacing was begun at twice diastolic threshold and ischemia was produced by balloon inflation. Repeat capture thresholds were obtained after 1. and 8 minutes of ischemia. Transcoronary pacing was successfully performed in all seven animals and was continued for a mean of 13.8 +/- 1.5 minutes. The baseline capture threshold was 4.0 +/- 0.5 mA. The mean capture threshold was 3.3 +/- 0.3 mA and 4.5 +/- 0.9 mA at 1 and 8 minutes of ischemia, respectively. We conclude that transcoronary pacing using the angioplasty guidewire can be successfully performed during myocardial ischemia and may serve as a reliable backup system during interventional procedures complicated by bradyarrhythmias. (C) 1993 Wiley-Liss, Inc. RP LAIRD, JR (reprint author), WALTER REED ARMY MED CTR,CARDIOL SERV,WASHINGTON,DC 20307, USA. NR 13 TC 2 Z9 2 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0098-6569 J9 CATHETER CARDIO DIAG JI Catheter. Cardiovasc. Diagn. PD OCT PY 1993 VL 30 IS 2 BP 162 EP 165 PG 4 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA MA075 UT WOS:A1993MA07500016 PM 8221872 ER PT J AU TORRINGTON, KG KERN, JD AF TORRINGTON, KG KERN, JD TI THE UTILITY OF FIBEROPTIC BRONCHOSCOPY IN THE EVALUATION OF THE SOLITARY PULMONARY NODULE SO CHEST LA English DT Article ID BRONCHOGENIC-CARCINOMA; LUNG-CANCER AB To determine the value of routine, preoperative, fiberoptic bronchoscopy (FB) for diagnosing and treating patients (pts) with solitary pulmonary nodules (SPNs), we retrospectively reviewed the records of all pts with SPNs undergoing FB at Walter Reed Army Medical Center between january 1986 and December 1989. We defined SPNs radiographically as less-than-or-equal-to 6 cm peripheral pulmonary lesions completely surrounded by pulmonary parenchyma. Of 191 charts reviewed, 91 (72 bronchogenic carcinomas [BC], 7 carcinoid tumors, 12 benign) constitute the study population. Fifty-four charts were eliminated because preoperative, clinical-radiologic staging revealed advanced (greater than stage I) BC or extrathoracic malignancy metastatic to the lung (44), the clinicians suspected benign disease and elected medical followup (3), the pt had medically inoperable disease (3), or the pt refused surgery (4). Forty-six charts were incomplete or unavailable. Fiberoptic bronchoscopy revealed one unsuspected vocal cord carcinoma and no occult synchronous BCs. Five pts had submucosal or endobronchial tumors and biopsy specimens showed BC in four of five tumors from which specimens were taken. Four of 66 (6 percent) cytologic evaluations of bronchial brushings or washings diagnosed BC. In pts shown at surgery to have BC, 9 of 30 transbronchial lung biopsy (TBBx) specimens showed BC. Diagnostic yield of TBBx specimens was not improved in the pts who underwent biopsies under fluoroscopic guidance. The 16 FB specimens positive for BC concurred 100 percent with the surgical specimens. The FB findings did not obviate the need for surgery nor alter the surgical stage of BC. A preoperative diagnosis of malignancy did not affect operative time or operative procedure, because many pts required frozen-section biopsy of mediastinal lymph nodes prior to lung resection. At our institution, routine, preoperative FB did not measurably benefit pts with SPNs. C1 WALTER REED ARMY MED CTR,DEPT MED,WASHINGTON,DC 20307. RP TORRINGTON, KG (reprint author), WALTER REED ARMY MED CTR,PULM & CRIT CARE MED SERV,BLDG 1,RM C223,WASHINGTON,DC 20307, USA. NR 15 TC 72 Z9 74 U1 0 U2 2 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 SN 0012-3692 J9 CHEST JI Chest PD OCT PY 1993 VL 104 IS 4 BP 1021 EP 1024 DI 10.1378/chest.104.4.1021 PG 4 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA MC283 UT WOS:A1993MC28300012 PM 8404158 ER PT J AU JOHNS, JP VERNALIS, MN KAREMAKER, JM LATHAM, RD AF JOHNS, JP VERNALIS, MN KAREMAKER, JM LATHAM, RD TI DOPPLER EVALUATION OF CARDIAC FILLING AND EJECTION PROPERTIES IN MAN DURING PARABOLIC FLIGHT SO CIRCULATION LA English DT Meeting Abstract C1 UNIV NEVADA,RENO,NV 89557. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. VET ADM MED CTR,RENO,NV. UNIV AMSTERDAM,AMSTERDAM,NETHERLANDS. USA,ARL,FT RUCKER,AL 36360. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER HEART ASSOC PI DALLAS PA 7272 GREENVILLE AVENUE, DALLAS, TX 75231-4596 SN 0009-7322 J9 CIRCULATION JI Circulation PD OCT PY 1993 VL 88 IS 4 BP 409 EP 409 PN 2 PG 1 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA MA682 UT WOS:A1993MA68202232 ER PT J AU WOODWARD, PR AF WOODWARD, PR TI INTERACTIVE SCIENTIFIC VISUALIZATION OF FLUID-FLOW SO COMPUTER LA English DT Article RP WOODWARD, PR (reprint author), UNIV MINNESOTA,ARMY HIGH PERFORMANCE COMP RES CTR,1100 WASHINGTON AVE S,MINNEAPOLIS,MN 55415, USA. NR 12 TC 21 Z9 21 U1 0 U2 0 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1264 SN 0018-9162 J9 COMPUTER JI Computer PD OCT PY 1993 VL 26 IS 10 BP 13 EP 25 DI 10.1109/2.237446 PG 13 WC Computer Science, Hardware & Architecture; Computer Science, Software Engineering SC Computer Science GA MA718 UT WOS:A1993MA71800013 ER PT J AU TEZDUYAR, T ALIABADI, S BEHR, M JOHNSON, A MITTAL, S AF TEZDUYAR, T ALIABADI, S BEHR, M JOHNSON, A MITTAL, S TI PARALLEL FINITE-ELEMENT COMPUTATION OF 3D FLOWS SO COMPUTER LA English DT Article ID FLUID-DYNAMICS C1 UNIV MINNESOTA,ARMY HIGH PERFORMANCE COMP RES CTR,MINNEAPOLIS,MN 55455. RP TEZDUYAR, T (reprint author), UNIV MINNESOTA,DEPT AEROSP ENGN & MECH,107 AKERMAN HALL,MINNEAPOLIS,MN 55455, USA. RI Behr, Marek/H-5401-2011; Tezduyar, Tayfun/F-6134-2012 OI Behr, Marek/0000-0003-4257-8276; Tezduyar, Tayfun/0000-0001-8707-3162 NR 13 TC 155 Z9 155 U1 1 U2 2 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1264 SN 0018-9162 J9 COMPUTER JI Computer PD OCT PY 1993 VL 26 IS 10 BP 27 EP 36 DI 10.1109/2.237441 PG 10 WC Computer Science, Hardware & Architecture; Computer Science, Software Engineering SC Computer Science GA MA718 UT WOS:A1993MA71800014 ER PT J AU JAFFIN, JH CHAMPION, HR BOULANGER, BR AF JAFFIN, JH CHAMPION, HR BOULANGER, BR TI ECONOMIC-CONSIDERATIONS SO CRITICAL CARE CLINICS LA English DT Article RP JAFFIN, JH (reprint author), BROOKE ARMY MED CTR,DEPT SURG,FT SAM HOUSTON,TX 78234, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0749-0704 J9 CRIT CARE CLIN JI Crit. Care Clin. PD OCT PY 1993 VL 9 IS 4 BP 765 EP 774 PG 10 WC Critical Care Medicine SC General & Internal Medicine GA MW341 UT WOS:A1993MW34100009 PM 8252443 ER PT J AU DUNCAN, WE LINVILLE, N CLEMENT, S AF DUNCAN, WE LINVILLE, N CLEMENT, S TI ASSESSING RISK-FACTORS WHEN SCREENING FOR DIABETES-MELLITUS SO DIABETES CARE LA English DT Letter C1 WALTER REED ARMY MED CTR,DEPT MED,KYLE METAB UNIT,WASHINGTON,DC 20307. RP DUNCAN, WE (reprint author), WALTER REED ARMY MED CTR,DEPT MED,ENDOCRINE METAB SERV,WASHINGTON,DC 20307, USA. NR 6 TC 6 Z9 8 U1 0 U2 2 PU AMER DIABETES ASSOC PI ALEXANDRIA PA 1660 DUKE ST, ALEXANDRIA, VA 22314 SN 0149-5992 J9 DIABETES CARE JI Diabetes Care PD OCT PY 1993 VL 16 IS 10 BP 1403 EP 1404 PG 2 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA LY180 UT WOS:A1993LY18000016 PM 8269803 ER PT J AU CHAPMAN, C BLAYDON, S CLEMENT, S SKIBAPOWELL, H HUME, RF AF CHAPMAN, C BLAYDON, S CLEMENT, S SKIBAPOWELL, H HUME, RF TI UTILITY OF ROUTINE OPHTHALMOLOGIC EXAMINATION IN PATIENTS WITH GESTATIONAL DIABETES-MELLITUS SO DIABETES CARE LA English DT Letter C1 WALTER REED ARMY MED CTR,DIV OPHTHALMOL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DIV ENDOCRINOL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DIV MATERNAL FETAL MED,WASHINGTON,DC 20307. NR 2 TC 4 Z9 4 U1 0 U2 0 PU AMER DIABETES ASSOC PI ALEXANDRIA PA 1660 DUKE ST, ALEXANDRIA, VA 22314 SN 0149-5992 J9 DIABETES CARE JI Diabetes Care PD OCT PY 1993 VL 16 IS 10 BP 1413 EP 1414 PG 2 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA LY180 UT WOS:A1993LY18000026 PM 8269810 ER PT J AU MADUH, EU PORTER, DW BASKIN, SI AF MADUH, EU PORTER, DW BASKIN, SI TI CALCIUM-ANTAGONISTS - A ROLE IN THE MANAGEMENT OF CYANIDE POISONING SO DRUG SAFETY LA English DT Article C1 USA,MED RES INST CHEM DEF,SGRD UV PB,DIV PHARMACOL,BLDG E-3100,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 4 Z9 4 U1 0 U2 0 PU ADIS INTERNATIONAL LTD PI AUCKLAND PA 41 CENTORIAN DR, PRIVATE BAG 65901, MAIRANGI BAY, AUCKLAND 10, NEW ZEALAND SN 0114-5916 J9 DRUG SAFETY JI Drug Saf. PD OCT PY 1993 VL 9 IS 4 BP 237 EP 248 DI 10.2165/00002018-199309040-00001 PG 12 WC Public, Environmental & Occupational Health; Pharmacology & Pharmacy; Toxicology SC Public, Environmental & Occupational Health; Pharmacology & Pharmacy; Toxicology GA MC167 UT WOS:A1993MC16700001 PM 8260117 ER PT J AU CARR, FE FISHER, CU FEIN, HG SMALLRIDGE, RC AF CARR, FE FISHER, CU FEIN, HG SMALLRIDGE, RC TI THYROTROPIN-RELEASING-HORMONE STIMULATES C-JUN AND C-FOS MESSENGER-RIBONUCLEIC-ACID LEVELS - IMPLICATIONS FOR CALCIUM MOBILIZATION AND PROTEIN-KINASE-C ACTIVATION SO ENDOCRINOLOGY LA English DT Article ID PROLACTIN GENE-EXPRESSION; EPIDERMAL GROWTH-FACTOR; BETA GENE; TRANSCRIPTIONAL REGULATION; PHORBOL ESTER; RNA LEVELS; GH3 CELLS; PROMOTER; INDUCTION; PHOSPHORYLATION AB The hypothalamic neuropeptide TRH, through G-protein-coupled transmembrane pituitary receptors, rapidly stimulates intracellular signaling events that, in turn, stimulate gene transcription. Our previous studies in transfected pituitary tumor cells indicated that TRH stimulation of thyrotropin beta-subunit (TSHbeta) gene expression involves both calcium mobilization and protein kinase-C activation. To characterize the gene-proximal elements of the intracellular signaling pathways involved, we examined the effects of TRH, ionomycin, and phorbol ester (TPA) on cellular protooncogenes (c-jun and c-fos) known to be responsive to calcium mobilization and protein kinase-C activation. TRH stimulated a 3-fold increase in both c-jun and c-fos mRNA levels within 1 h, followed by a rapid decline in steady state mRNA levels. A secondary response to the single administration was noted, culminating in a 5-fold stimulation at 20 h. The increase in c-jun and c-fos mRNA levels occurred before the increased steady state mRNA levels of both PRL and TSHbeta chimera in transfected pituitary GH3 cells. Furthermore, we examined the role of calcium in these effects using the ionophore ionomycin to elevate and TMB-8 to decrease intracellular calcium. We used the phorbol ester TPA to investigate the effects of increased protein kinase-C activity and H7 or pretreatment with TPA to monitor the decreased kinase activity. Our data indicate that calcium mobilization and protein kinase activation represent distinct components of the signaling events initiated by TRH resulting in increased c-jun and c-fos mRNA levels. Only c-fos mRNA is increased by all three factors, suggesting that c-fos may be a key element in mediating the intracellular processes reflecting TRH action. C1 WALTER REED ARMY INST RES, DEPT CLIN PHYSIOL, DIV MED, WASHINGTON, DC 20307 USA. RP CARR, FE (reprint author), WALTER REED ARMY MED CTR, DEPT CLIN INVEST, RES LABS, KYLE METAB UNIT, 6800 GEORGIA AVE, WASHINGTON, DC 20307 USA. NR 38 TC 20 Z9 21 U1 0 U2 0 PU ENDOCRINE SOC PI CHEVY CHASE PA 8401 CONNECTICUT AVE, SUITE 900, CHEVY CHASE, MD 20815-5817 USA SN 0013-7227 EI 1945-7170 J9 ENDOCRINOLOGY JI Endocrinology PD OCT PY 1993 VL 133 IS 4 BP 1700 EP 1707 DI 10.1210/en.133.4.1700 PG 8 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA MA411 UT WOS:A1993MA41100029 PM 8404612 ER PT J AU MOCK, B BLACKWELL, J HILGERS, J POTTER, M NACY, C AF MOCK, B BLACKWELL, J HILGERS, J POTTER, M NACY, C TI GENETIC-CONTROL OF LEISHMANIA-MAJOR INFECTION IN CONGENIC, RECOMBINANT INBRED AND F2 POPULATIONS OF MICE SO EUROPEAN JOURNAL OF IMMUNOGENETICS LA English DT Article ID CUTANEOUS LEISHMANIASIS; HISTOCOMPATIBILITY; SUSCEPTIBILITY; TROPICA; STRAINS; LOCI AB The outcome of subcutaneous infection with L. major NIH 173 was evaluated in a series of recombinant inbred and congenic strains, as well as F2 progeny generated from a genetic linkage testing stock carrying the visible markers Ra, Os, and Pt. The disease parameters monitored were the incidence of open or necrotic lesions and footpad depths of infected feet, and the incidence and number of amastigotes in livers following infection. Regions of mouse chromosomes 2, 4, 7, 8, 12 and 15 were excluded from linkage to a gene (Scl-1) involved in the susceptibility of inbred strains of mice to cutaneous infection with L. major NIH 173 by F2 and congenic strain analyses. Strain distribution patterns generated for Scl-1 in the CXB and CXS recombinant inbred strains suggested linkage to the distal end of mouse Chromosome 11. C1 UNIV CAMBRIDGE,SCH CLIN,DEPT MED,CAMBRIDGE,ENGLAND. FREE UNIV AMSTERDAM,ACAD ZIEKENHUIS,DEPT OBSTET,1007 MC AMSTERDAM,NETHERLANDS. WALTER REED ARMY INST RES,DEPT CELLULAR IMMUNOL,WASHINGTON,DC 20307. RP MOCK, B (reprint author), NCI,GENET LAB,BLDG 37,ROOM 2B-08,BETHESDA,MD 20892, USA. RI Blackwell, Jenefer/H-3015-2015 NR 20 TC 42 Z9 42 U1 0 U2 1 PU BLACKWELL SCIENCE LTD PI OXFORD PA OSNEY MEAD, OXFORD, OXON, ENGLAND OX2 0EL SN 0960-7420 J9 EUR J IMMUNOGENET JI Eur. J. Immunogenet. PD OCT PY 1993 VL 20 IS 5 BP 335 EP 348 DI 10.1111/j.1744-313X.1993.tb00153.x PG 14 WC Genetics & Heredity; Immunology SC Genetics & Heredity; Immunology GA LZ761 UT WOS:A1993LZ76100003 PM 9098402 ER PT J AU HILBERT, DM HOLMES, KL ANDERSON, AO RUDIKOFF, S AF HILBERT, DM HOLMES, KL ANDERSON, AO RUDIKOFF, S TI LONG-TERM THYMIC RECONSTITUTION BY PERIPHERAL CD4 AND CD8 SINGLE-POSITIVE LYMPHOCYTES SO EUROPEAN JOURNAL OF IMMUNOLOGY LA English DT Article DE THYMIC IMMIGRATION; IN-VIVO LYMPHOCYTES HOMING; PEYER PATCHES; FLOW CYTOMETRY ID ACTIVATED T-CELLS; MONOCLONAL-ANTIBODIES; LINE CELLS; B-CELLS; MICE; MOUSE; RECEPTOR; EXPRESSION; ANTIGENS; THYMOCYTES AB Significant immigration of peripheral T cells into SCID thymus was observed following reconstitution with normal Peyer's patch, mesenteric lymph node or peripheral lymph node cells. Immunohistologic and flow cytometric analyses reveal that T cells from these tissues are found in the thymus for as long as 177 days and can account for up to 67% of intrathymic cells. The returning cells express the CD3/T cell receptor alpha/beta complex, indicative of mature cells, and are equally divided among helper (CD4+CD8-) and cytotoxic (CD4-/CD8+) phenotypes. The immigration of peripheral T cells is not accompanied by the appearance of immature, double-positive (CD4+CD8+) thymocytes as seen in similar reconstitutions using bone marrow. Taken together, these results suggest that peripheral T cells from a variety of lymphoid organs may regularly re-enter the thymus and, thus, possibly play a role in normal thymic development. C1 NIAID,BIOL RESOURCES BRANCH,FLOW CYTOMETRY SECT,BETHESDA,MD 20892. USA,MED RES INST INFECT DIS,DEPT RESP & MUCOSAL IMMUNOL,FREDERICK,MD 21701. RP HILBERT, DM (reprint author), NCI,GENET LAB,BETHESDA,MD 20892, USA. NR 40 TC 15 Z9 15 U1 0 U2 1 PU VCH PUBLISHERS INC PI DEERFIELD BEACH PA 303 NW 12TH AVE, DEERFIELD BEACH, FL 33442-1788 SN 0014-2980 J9 EUR J IMMUNOL JI Eur. J. Immunol. PD OCT PY 1993 VL 23 IS 10 BP 2412 EP 2418 DI 10.1002/eji.1830231006 PG 7 WC Immunology SC Immunology GA MD626 UT WOS:A1993MD62600005 PM 8405041 ER PT J AU PRUITT, BA AF PRUITT, BA TI CADAVEROUS PARTICLES AND INFECTION IN INJURED MAN SO EUROPEAN JOURNAL OF SURGERY LA English DT Article; Proceedings Paper CT 5TH ANNUAL MEETING OF THE SURGICAL-INFECTION-SOC-OF-EUROPE CY JUN 08-10, 1992 CL SANTIAGO, SPAIN SP SURG INFECT SOC EUROPE ID INHALATION INJURY; THERMAL-INJURY; BURN MORTALITY; COLONIZATION; BACTEREMIA; PNEUMONIA RP PRUITT, BA (reprint author), USA,INST SURG RES,FT SAM HOUSTON,TX 78234, USA. NR 35 TC 3 Z9 3 U1 0 U2 0 PU SCANDINAVIAN UNIVERSITY PRESS PI OSLO PA PO BOX 2959 TOYEN, JOURNAL DIVISION CUSTOMER SERVICE, N-0608 OSLO, NORWAY SN 1102-4151 J9 EUR J SURG JI Eur. J. Surg. PD OCT PY 1993 VL 159 IS 10 BP 515 EP 520 PG 6 WC Surgery SC Surgery GA MG588 UT WOS:A1993MG58800001 PM 8286507 ER PT J AU LETTERIE, GS HIBBERT, ML BRITTON, BA AF LETTERIE, GS HIBBERT, ML BRITTON, BA TI ENDOMETRIAL HISTOLOGY AFTER ELECTROCOAGULATION USING DIFFERENT POWER SETTINGS SO FERTILITY AND STERILITY LA English DT Article; Proceedings Paper CT 48TH ANNUAL MEETING OF THE AMERICAN-FERTILITY-SOC CY NOV 02-05, 1992 CL NEW ORLEANS, LA SP AMER FERTIL SOC DE ENDOMETRIAL ABLATION; ABNORMAL UTERINE BLEEDING; ENDOMETRIAL HISTOLOGY ID ABLATION; MENORRHAGIA AB Objective: To study endometrial histology after electrocoagulation in an in vitro model using 50 watts (W) and 100 W of coagulation current and determine the depth of endometrial destruction and survival, if any, of glands beneath this zone. Design: Twenty fresh uteri of similar weights and dimensions were obtained from patients undergoing hysterectomy for benign disease. Specimens were bivalved into anterior and posterior walls and each wall divided in half. Endometrial electrocoagulation was carried out with a 5-mm probe at 50 W and 100 W applied to anterior and posterior quarters of the specimen, respectively. The adjacent untreated endometrial surfaces served as controls. Specimens were formalin-fixed, embedded in paraffin, and sections stained with hematoxylin and eosin. Main Outcome Measures: The number and morphology of the endometrial glands were counted and classified manually for each section and compared between each power setting and controls. Results: Histologic examination revealed morphologically normal glands in all specimens beneath the zone of destruction regardless of power setting. Both power settings produced significant focal and diffuse glandular and stromal destruction when compared with controls. Significant differences were noted in the number of normal glands after treatment with 50 W (71.33 glands +/- 76.44 [mean +/- SD]), 100 W (21.11 +/- 35.71) and untreated controls (240.16 +/- 110.81). Tissue destruction increased with increasing power, and there were significant differences in the percentage of morphologically normal, surviving glands between 50 W (11.7% +/- 11.4% [mean +/- SD]) and 100 W (4.9% +/- 10.9%). Conclusion: These data suggest that electrocoagulation may result in a variable degree of endometrial destruction dependent on power. Viable glands and stroma may survive beneath the zone of destruction regardless of power. Such variations in endometrial insult in an in vitro model may explain, in part, the variable clinical results of endometrial electrocoagulation. The survival of glands beneath the zone of destruction in this model raises the theoretical concern for occult malignant changes and leaves open to question the exact role and mode of hormonal therapy during the menopause after endometrial ablation. C1 TRIPLER ARMY MED CTR,HONOLULU,HI 96859. NR 12 TC 16 Z9 17 U1 0 U2 0 PU AMER SOC REPRODUCTIVE MEDICINE PI BIRMINGHAM PA 1209 MONTGOMERY HIGHWAY, BIRMINGHAM, AL 35216-2809 SN 0015-0282 J9 FERTIL STERIL JI Fertil. Steril. PD OCT PY 1993 VL 60 IS 4 BP 647 EP 651 PG 5 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA MB013 UT WOS:A1993MB01300009 PM 8405518 ER PT J AU VANDENBERG, AP VANKEKEN, PE YUEN, DA AF VANDENBERG, AP VANKEKEN, PE YUEN, DA TI THE EFFECTS OF A COMPOSITE NON-NEWTONIAN AND NEWTONIAN RHEOLOGY ON MANTLE CONVECTION SO GEOPHYSICAL JOURNAL INTERNATIONAL LA English DT Article DE MANTLE CONVECTION; RHEOLOGY; VISCOSITY ID THERMAL-CONVECTION; EARTHS MANTLE; CREEP LAWS; LITHOSPHERE; VELOCITY; PLATES; VISCOSITY; DYNAMICS; NUMBER AB A finite element method based on a primitive variables formulation is used to model both steady-state and time-dependent mantle convection with a composite Newtonian and non-Newtonian (power-law) rheology. The rheological model employs the transition stress as a means of partitioning the relative importance of the two rheologies. Results show that there is no direct correlation between viscosity and temperature anomalies. Fluctuations of the velocity fields are much greater and faster than for Newtonian flows. Fluctuations with amplitudes several times the background velocity are quite common. Intermittency effects with quiescent periods punctuated by chaotic bursts are observed. From scaling arguments temporal fluctuations of the volume-averaged viscosity are comparable in magnitude to the variations in the surface heat flow for the non-Newtonian flows, but are smaller than the variations in the velocity field. At larger transition stress the Newtonian behaviour becomes dominant and the temporal variations of the viscosity diminish. Both steady-state and time-dependent results show that for a given transition stress the non-Newtonian behaviour prevails to a greater extent with increasing Rayleigh number. Implications of this non-Newtonian tendency for Archaean tectonics are discussed. C1 UNIV MINNESOTA,MINNESOTA SUPERCOMP INST,DEPT GEOL & GEOPHYS,MINNEAPOLIS,MN 55414. UNIV MINNESOTA,ARMY HIGH PERFORMANCE COMP RES CTR,MINNEAPOLIS,MN 55414. RP VANDENBERG, AP (reprint author), UNIV UTRECHT,DEPT THEORET GEOPHYS,POB 80021,BUDAPESTLAAN 4,3508 TA UTRECHT,NETHERLANDS. NR 42 TC 83 Z9 83 U1 1 U2 3 PU BLACKWELL SCIENCE LTD PI OXFORD PA OSNEY MEAD, OXFORD, OXON, ENGLAND OX2 0EL SN 0956-540X J9 GEOPHYS J INT JI Geophys. J. Int. PD OCT PY 1993 VL 115 IS 1 BP 62 EP 78 PG 17 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA LZ782 UT WOS:A1993LZ78200004 ER PT J AU GOODMAN, ZD MCNALLY, PR DAVIS, D ISHAK, KG AF GOODMAN, ZD MCNALLY, PR DAVIS, D ISHAK, KG TI AUTOIMMUNE CHOLANGITIS - A VARIANT OF PRIMARY BILIARY-CIRRHOSIS SO HEPATOLOGY LA English DT Meeting Abstract C1 USA,INST PATHOL,DIV HEPAT PATHOL,WASHINGTON,DC 20310. FITZSIMONS ARMY MED CTR,DIV GASTROENTEROL,AURORA,CO 80045. NR 0 TC 3 Z9 3 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0270-9139 J9 HEPATOLOGY JI Hepatology PD OCT PY 1993 VL 18 IS 4 BP A109 EP A109 DI 10.1016/0270-9139(93)91966-V PN 2 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA LY995 UT WOS:A1993LY99500212 ER PT J AU HADFIELD, TL WARREN, R KASS, M BRUN, E LEVY, C AF HADFIELD, TL WARREN, R KASS, M BRUN, E LEVY, C TI ENDOCARDITIS CAUSED BY ROCHALIMAEA-HENSELAE SO HUMAN PATHOLOGY LA English DT Note DE ROCHALIMAEA SP; ENDOCARDITIS; POLYMERASE CHAIN REACTION; DNA SEQUENCE ID BACILLARY ANGIOMATOSIS; SP-NOV; INFECTION; PELIOSIS; BLOOD C1 WALTER REED ARMY INST RES,DEPT BACTERIAL DIS,WASHINGTON,DC 20307. WASHINGTON HOSP CTR,DEPT INFECT DIS,WASHINGTON,DC 20010. WASHINGTON HOSP CTR,DEPT PATHOL,WASHINGTON,DC 20010. RP HADFIELD, TL (reprint author), ARMED FORCES INST PATHOL,DIV MICROBIOL,BLDG 54,CPS-M,WASHINGTON,DC 20306, USA. NR 8 TC 99 Z9 105 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0046-8177 J9 HUM PATHOL JI Hum. Pathol. PD OCT PY 1993 VL 24 IS 10 BP 1140 EP 1141 DI 10.1016/0046-8177(93)90196-N PG 2 WC Pathology SC Pathology GA MC195 UT WOS:A1993MC19500015 PM 8406424 ER PT J AU CHANG, SKW AF CHANG, SKW TI ELECTRIC-FIELD-INDUCED VOLUME AND MEMBRANE IONIC PERMEABILITY CHANGES OF RED-BLOOD-CELLS SO IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING LA English DT Article ID LIPID BILAYER-MEMBRANES; HUMAN-ERYTHROCYTES; BREAKDOWN AB When an external electric field (EF) is applied to red blood cells (RBC's), the RBC's are observed to undergo a swelling action. The swelling may or may not lead to hemolysis, depending on the EF strength. An objective verification of this swelling is by measuring the RBC mean corpuscular volume (MCV). In this study, the RBC's were exposed to.the appropriate EF strength to induce swelling, but caused minimal hemolysis. The MCV was measured. The change in the erythrocyte membrane ionic permeability as a result of the EF exposure was also determined, as an objective verification of presumed membrane conductance change concomitant with the swelling. The fluxes of cations K+, Na+, and Ca++ and anion Cl- were measured. The results showed that red cell MCV was indeed increased after EF application. The EF also altered the membrane ionic conductance to allow ions to flow down their respective concentration gradient across the membrane. Without a counterbalancing ionic pressure gradient, hemoglobin colloidal pressure inevitably drew H2O in, thus producing the observed swelling. RP CHANG, SKW (reprint author), USA,ENVIRONM MED RES INST,DIV BIOPHYS & BIOMED MODELING,NATICK,MA 01760, USA. NR 11 TC 4 Z9 5 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9294 J9 IEEE T BIO-MED ENG JI IEEE Trans. Biomed. Eng. PD OCT PY 1993 VL 40 IS 10 BP 1054 EP 1059 DI 10.1109/10.247804 PG 6 WC Engineering, Biomedical SC Engineering GA MK080 UT WOS:A1993MK08000008 PM 8294130 ER PT J AU MINK, JW SCHWERING, FK AF MINK, JW SCHWERING, FK TI A HYBRID DIELECTRIC SLAB-BEAM WAVE-GUIDE FOR THE SUBMILLIMETER-WAVE REGION SO IEEE TRANSACTIONS ON MICROWAVE THEORY AND TECHNIQUES LA English DT Article AB A hybrid dielectric slab-beam waveguide is suggested which should be well suited as transmission medium for the design of planar quasi-optical integrated circuits and devices operating in the mm and sub-mm wave regions. The new guide consists of a grounded' dielectric slab into which a sequence of equally spaced cylindrical lenses is fabricated. (The center line of the slab guide is the axis of the lenses). The structure uses two distinct wave guiding principles in conjunction with each other to guide electromagnetic waves. In the direction normal to the slab surface, the guided fields behave as surface waves of the slab guide; their energy is largely confined to the interior of the dielectric and they are guided by total reflection at the slab surface. In the lateral direction the waves behave as Gauss-Hermite beammodes that are guided by the lenses which periodically reconstitute their cross sectional phase distribution, resulting in a wave beam that is iterated with the lens spacing. The guided fields are in effect TE and TM modes. The analysis of the new guiding structure is presented: The mode spectrum is calculated and the iteration loss due to the finite size of the lenses is estimated. C1 USA,CECOM,FT MONMOUTH,NJ 07703. RP MINK, JW (reprint author), USA,RES OFF,POB 12211,RES TRIANGLE PK,NC 27709, USA. NR 9 TC 11 Z9 11 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9480 J9 IEEE T MICROW THEORY JI IEEE Trans. Microw. Theory Tech. PD OCT PY 1993 VL 41 IS 10 BP 1720 EP 1729 DI 10.1109/22.247917 PG 10 WC Engineering, Electrical & Electronic SC Engineering GA ML422 UT WOS:A1993ML42200009 ER PT J AU HERON, PL MONAHAN, GP MINK, JW SCHWERING, FK STEER, MB AF HERON, PL MONAHAN, GP MINK, JW SCHWERING, FK STEER, MB TI IMPEDANCE MATRIX OF AN ANTENNA-ARRAY IN A QUASI-OPTICAL RESONATOR SO IEEE TRANSACTIONS ON MICROWAVE THEORY AND TECHNIQUES LA English DT Article ID OSCILLATOR AB The power from numerous millimeter wave solid-state sources can be efficiently combined using quasi-optical techniques. One such technique is to place an array of active radiating sources within a quasi-optical resonator. The driving point impedance of each antenna is strongly affected by the presence of all other active antennas as well as by the mode structure and Q of the resonator. In this paper the impedance matrix for an array of antennas radiating into a plano-concave open resonator is determined through use of the Lorentz integral. The resulting expressions include the effect of diffraction loss and are valid for arbitrary reflector spacing, source frequency, array location and geometry. The result can be used to impedance match each active source to its antenna and thus facilitate design of an efficient power combining system. Simulations using the impedance matrix in conjunction with an antenna impedance model are compared with two-port measurements. C1 USA,RES OFF,RES TRIANGLE PK,NC 27709. CECOM,FT MONMOUTH,NJ 07703. N CAROLINA STATE UNIV,DEPT ELECT & COMP ENGN,HIGH FREQUENCY ELECTR LAB,RALEIGH,NC 27695. NR 24 TC 3 Z9 3 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9480 J9 IEEE T MICROW THEORY JI IEEE Trans. Microw. Theory Tech. PD OCT PY 1993 VL 41 IS 10 BP 1816 EP 1826 DI 10.1109/22.247928 PG 11 WC Engineering, Electrical & Electronic SC Engineering GA ML422 UT WOS:A1993ML42200020 ER PT J AU BRENNER, DJ GRIMONT, PAD STEIGERWALT, AG FANNING, GR AGERON, E RIDDLE, CF AF BRENNER, DJ GRIMONT, PAD STEIGERWALT, AG FANNING, GR AGERON, E RIDDLE, CF TI CLASSIFICATION OF CITROBACTERIA BY DNA HYBRIDIZATION - DESIGNATION OF CITROBACTER-FARMERI SP-NOV, CITROBACTER-YOUNGAE SP-NOV, CITROBACTER-BRAAKII SP-NOV, CITROBACTER-WERKMANII SP-NOV, CITROBACTER-SEDLAKII SP-NOV, AND 3 UNNAMED CITROBACTER GENOMOSPECIES SO INTERNATIONAL JOURNAL OF SYSTEMATIC BACTERIOLOGY LA English DT Article ID CLINICAL SPECIMENS; IDENTIFICATION AB DNA relatedness studies (hydroxyapatite method) were done on 112 strains of citrobacteria. By using the recommended definition of a genomospecies 11 genomospecies were identified in the genus Citrobacter. These genomospecies were separable by their biochemical profiles. Citrobacter koseri (Citrobacter diversus) and Citrobacter amalonaticus proved to be homogeneous species, as previously described. C. amalonaticus biogroup 1, as described by Farmer et al. (J. Clin. Microbiol. 21:46-76, 1985), was shown to be a separate homogeneous species, which was named Citrobacter farmeri sp. nov. The Citrobacter freundii complex was quite heterogeneous. C.freundii sensu stricto, as represented by the type strain, contained only 9 of 66 strains in this complex. The remaining 57 strains were members of seven genomospecies. Genomospecies 5, containing 21 strains, was named Citrobacter youngae sp. nov. Genomospecies 6, containing 15 strains, was named Citrobacter braakii sp. nov. Genomospecies 7 and 8, each containing six strains, were named Citrobacter werkmanii sp. nov. and Citrobacter sedlakii sp. nov., respectively. Genomospecies 9, 10, and 11, each containing three strains, were not named. C1 CTR DIS CONTROL & PREVENT,NATL CTR INFECT DIS,NOSOCOMIAL INFECT LAB BRANCH,HOSP INFECT PROGRAM,ATLANTA,GA 30333. INST PASTEUR,INST NATL RECH SCI,UNITE ENTEROBACTERIES,UNITE 199,F-75724 PARIS 15,FRANCE. WALTER REED ARMY INST RES,DIV BIOCHEM,WASHINGTON,DC 20307. RP BRENNER, DJ (reprint author), CTR DIS CONTROL & PREVENT,NATL CTR INFECT DIS,DIV BACTERIOL & MYCOT DIS,ATLANTA,GA 30333, USA. NR 15 TC 93 Z9 96 U1 3 U2 16 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0020-7713 J9 INT J SYST BACTERIOL JI Int. J. Syst. Bacteriol. PD OCT PY 1993 VL 43 IS 4 BP 645 EP 658 PG 14 WC Microbiology SC Microbiology GA MC210 UT WOS:A1993MC21000003 PM 8240948 ER PT J AU YANG, LW WRIGHT, PD SHEN, H LU, Y BRUSENBACK, PR KO, SK CALDERON, L HARTZLER, WD HAN, WY DUTTA, M CHANG, WH AF YANG, LW WRIGHT, PD SHEN, H LU, Y BRUSENBACK, PR KO, SK CALDERON, L HARTZLER, WD HAN, WY DUTTA, M CHANG, WH TI EFFECTS OF HEAVILY CARBON-DOPED BASE LAYERS ON PERFORMANCE OF SUBMICRON ALGAAS GAAS HETEROJUNCTION BIPOLAR-TRANSISTORS SO JAPANESE JOURNAL OF APPLIED PHYSICS PART 2-LETTERS LA English DT Article DE SUBMICRON; SURFACE RECOMBINATION; NONRADIATIVE RECOMBINATION; INTEGRATED PHOTOLUMINESCENCE INTENSITY; HBT ID CURRENT GAIN; RECOMBINATION; HBTS; TETRACHLORIDE; JUNCTION; MOCVD AB Submicron heterojunction bipolar transistors (HBTs) with maximum frequency of oscillation, f(MAX), of 91 GHz have been fabricated using a self-aligned technique and a very heavily carbon-doped (10(20) cm-3) base layer. Since the quenching of photoluminescence (PL) intensity in heavily-doped GaAs is mainly due to nonradiative recombination in the bulk material, while contribution from surface recombination is negligible, the use of a heavily carbon-doped base layer in AlGaAs/GaAs HBTs minimizes the influence of surface recombination in the extrinsic base region. Thus, for HBTs with a heavily doped base layer, the ''emitter size effect'' (degradation of HBT current gain) is greatly reduced when the emitter width is scaled down to submicron (0.6 mum) dimensions. C1 FORD MICROELECTR INC,COLORADO SPRINGS,CO 80921. MARTIN KESTREL CO INC,COLORADO SPRINGS,CO 80919. USA,ELECTR TECHNOL & DEVICE LAB,FT MONMOUTH,NJ 07703. RUTGERS UNIV,DEPT ELECT & COMP ENGN,PISCATAWAY,NJ 08855. NR 15 TC 0 Z9 0 U1 0 U2 0 PU JAPAN J APPLIED PHYSICS PI MINATO-KU TOKYO PA DAINI TOYOKAIJI BLDG 24-8 SHINBASHI 4-CHOME, MINATO-KU TOKYO 105, JAPAN SN 0021-4922 J9 JPN J APPL PHYS 2 JI Jpn. J. Appl. Phys. Part 2 - Lett. PD OCT 1 PY 1993 VL 32 IS 10A BP L1400 EP L1402 PG 3 WC Physics, Applied SC Physics GA MC044 UT WOS:A1993MC04400010 ER PT J AU MICHAEL, NL CHANG, G EHRENBERG, PK VAHEY, MT REDFIELD, RR AF MICHAEL, NL CHANG, G EHRENBERG, PK VAHEY, MT REDFIELD, RR TI HIV-1 PROVIRAL GENOTYPES FROM THE PERIPHERAL-BLOOD MONONUCLEAR-CELLS OF AN INFECTED PATIENT ARE DIFFERENTIALLY REPRESENTED IN EXPRESSED SEQUENCES SO JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY LA English DT Article DE HUMAN IMMUNODEFICIENCY VIRUS; VIRAL VARIATION; GP120 GENE; CDNA; POLYMERASE CHAIN REACTION ID IMMUNODEFICIENCY-VIRUS TYPE-1; HTLV-III; AIDS; EVOLUTION; INVIVO; POPULATIONS; DISEASE; TISSUE; DOMAIN; SPLEEN AB The RNA genome of the human immunodeficiency virus type 1 (HIV-1) is established as proviral DNA in infected cells. Only some of these cells may actively produce the array of viral RNAs that support progeny virion production. In vivo expression of a subset of proviral genotypes could influence the experimental characterization of the viral quasispecies. We have explored the relationship between DNA and cDNA genotypes of the envelope gene by the molecular cloning and nucleotide sequencing of these templates from noncultivated peripheral blood mononuclear cells from an HIV-1-infected patient. Eleven proviral DNA and nine cDNA clones representing the V1-V3 region of gp120 were recovered and sequenced. The proviral group was more heterogeneous than the cDNA group by nucleotide sequence changes and V1 length polymorphisms. Deduced amino acid sequences from this data set showed that the two groups were distinct in primary structure, in the position of N-linked glycosylation sites, and in the net charge of the V3 loop. The V1-V2 region discriminated between the groups more strongly than the V3 region. The differential representation of HIV-1 envelope genotypes in the cDNA versus the proviral compartment may have important implications for the pathogenesis of disease and for the design of antiviral therapeutics. C1 HENRY M JACKSON FDN,ROCKVILLE,MD. RP MICHAEL, NL (reprint author), WALTER REED ARMY INST RES,DEPT RETROVIRAL RES,13 TAFT COURT,SUITE 200,ROCKVILLE,MD 20850, USA. NR 23 TC 28 Z9 28 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 1077-9450 J9 J ACQ IMMUN DEF SYND JI J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. PD OCT PY 1993 VL 6 IS 10 BP 1073 EP 1085 PG 13 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA MC829 UT WOS:A1993MC82900001 PM 8105071 ER PT J AU ERDOGAN, MU KIM, KW STROSCIO, MA DUTTA, M AF ERDOGAN, MU KIM, KW STROSCIO, MA DUTTA, M TI EXTENSION OF THE KRONIG-PENNEY MODEL FOR GAMMA-X MIXING IN SUPERLATTICES SO JOURNAL OF APPLIED PHYSICS LA English DT Note ID GAAS-ALAS SUPERLATTICES; HETEROSTRUCTURES AB An extension of the Kronig-Penney model to treat mixings of different valleys in superlattices is presented. The value of the mixing parameter alpha used in the model is deduced by comparison with more sophisticated theory and various experiments for the GaAs/A]As material system. It is shown that with the use of a single value for the mixing parameter, this simple and efficient model can reasonably reproduce the important aspects of valley mixing effects in GaAs/AlAs superlattices over a wide range of layer thicknesses. C1 USA,RES OFF,RES TRIANGLE PK,NC 27709. USA,RES LAB,ELECTR & POWER SOURCES DIRECTORATE,FT MONMOUTH,NJ 07703. RP ERDOGAN, MU (reprint author), N CAROLINA STATE UNIV,DEPT ELECT & COMP ENGN,RALEIGH,NC 27695, USA. NR 16 TC 4 Z9 4 U1 0 U2 2 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD OCT 1 PY 1993 VL 74 IS 7 BP 4777 EP 4779 PG 3 WC Physics, Applied SC Physics GA MB177 UT WOS:A1993MB17700071 ER PT J AU ROSEN, LN TEITELBAUM, JM WESTHUIS, DJ AF ROSEN, LN TEITELBAUM, JM WESTHUIS, DJ TI STRESSORS, STRESS MEDIATORS, AND EMOTIONAL WELL-BEING AMONG SPOUSES OF SOLDIERS DEPLOYED TO THE PERSIAN-GULF DURING OPERATION DESERT SHIELD STORM SO JOURNAL OF APPLIED SOCIAL PSYCHOLOGY LA English DT Article AB The Family Factors Field Study of Operation Desert Shield/Storm (ODS) was designed to collect data on the impact of the Persian Gulf deployment on soldier/family well-being, and the effectiveness of Army and community resources in assisting and supporting families of deployed soldiers. In October 1990, a task force was assembled, and multi-agency research teams visited several Army installations. Informal individual and group interviews were conducted with spouses, unit family support leaders, unit rear detachment personnel, garrison leaders, and local Army program/service providers. The questions were aimed at identifying key stressors which spouses and children experienced in relation to the sudden deployment, as well a stress mediators such as social supports and personal coping skills. Anecdotal information collected during the site visits, combined with findings from previous research on Army families, was used to develop a questionnaire designed to quantify those variables which emerged as relevant to a study of stressors and stress mediators in the context of the ODS deployment. C1 USA,HLTH CARE STUDIES & ANAL DIRECTORATE,FT SAM HOUSTON,TX 78234. RP ROSEN, LN (reprint author), WALTER REED ARMY INST RES,DEPT MIL PSYCHIAT,SGRD UWIA,WASHINGTON,DC 20307, USA. NR 3 TC 16 Z9 16 U1 0 U2 1 PU V H WINSTON & SON INC PI PALM BEACH PA 360 SOUTH OCEAN BLVD, PH-B, PALM BEACH, FL 33480 SN 0021-9029 J9 J APPL SOC PSYCHOL JI J. Appl. Soc. Psychol. PD OCT 1 PY 1993 VL 23 IS 19 BP 1587 EP 1593 DI 10.1111/j.1559-1816.1993.tb01049.x PG 7 WC Psychology, Social SC Psychology GA MU903 UT WOS:A1993MU90300003 ER PT J AU LIEWEHR, FR KULILD, JC PRIMACK, PD AF LIEWEHR, FR KULILD, JC PRIMACK, PD TI IMPROVED DENSITY OF GUTTA-PERCHA AFTER WARM LATERAL CONDENSATION SO JOURNAL OF ENDODONTICS LA English DT Article ID OBTURATION TECHNIQUES AB Simulated straight root canals in 30 transparent acrylic blocks were instrumented and obturated with gutta-percha without sealer using standard lateral condensation (group A). The ''zap and tap'' method of warm lateral condensation was then used on the same 30 canals (group B). A second treatment of warm lateral condensation was then applied to these same canals (group C). The acrylic blocks were weighed after initial canal preparation and after each subsequent obturation. A 14.63% increase in weight of the gutta-percha occurred in group B compared with group A, and a 2.43% increase in weight occurred in group C compared with group B. Both differences were statistically significant (p < 0.001). C1 USA,POSTGRAD DENT SCH,ARMY DENT ACT,ENDODONT RESIDENCY PROGRAM,FT GORDON,GA 30905. NR 10 TC 8 Z9 9 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0099-2399 J9 J ENDODONT JI J. Endod. PD OCT PY 1993 VL 19 IS 10 BP 489 EP 491 DI 10.1016/S0099-2399(06)81488-3 PG 3 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA MA787 UT WOS:A1993MA78700001 PM 8120482 ER PT J AU TEWFIK, HM PASHLEY, DH HORNER, JA SHARAWY, MM AF TEWFIK, HM PASHLEY, DH HORNER, JA SHARAWY, MM TI STRUCTURAL AND FUNCTIONAL-CHANGES IN ROOT DENTIN FOLLOWING EXPOSURE TO KTP/532 LASER SO JOURNAL OF ENDODONTICS LA English DT Article ID CANAL-WALL DENTIN; PERMEABILITY; CO2-LASER AB The use of a new, modified Nd:YAG laser called the KTP/532 laser was evaluated within root canals to determine whether it would modify dentin permeability or alter the scanning electron microscopic appearance of canal dentin. Energies and exposure times were chosen which did not permit periodontal temperatures to increase above 5-degrees-C (1 W x 1 s-5 W x 0.5 s). Half of the root canals were covered with smear layer and half were treated with EDTA/NaOCl to remove the smear layer. The results showed that this laser did not change the permeability of the smear layer-covered dentin, although scanning electron microscopic examination revealed modifications to the surface of smear layer. Lasing of etched dentin produced modest increases in root permeability which were associated with enlargement and cracking of tubule orifices. C1 MED COLL GEORGIA,SCH DENT,DEPT ORAL BIOL,AUGUSTA,GA 30912. CAIRO UNIV,FAC ORAL & DENT MED,DEPT ENDODONT,CAIRO,EGYPT. DWIGHT D EISENHOWER ARMY MED CTR,ELECTRON MICROSCOPE LAB,FT GORDON,GA 30905. FU NIDCR NIH HHS [DE06427] NR 17 TC 21 Z9 22 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0099-2399 J9 J ENDODONT JI J. Endod. PD OCT PY 1993 VL 19 IS 10 BP 492 EP 497 DI 10.1016/S0099-2399(06)81489-5 PG 6 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA MA787 UT WOS:A1993MA78700002 PM 8120483 ER PT J AU LONG, CE WIBERG, PL NOWELL, ARM AF LONG, CE WIBERG, PL NOWELL, ARM TI EVALUATION OF VONKARMAN CONSTANT FROM INTEGRAL FLOW PARAMETERS SO JOURNAL OF HYDRAULIC ENGINEERING-ASCE LA English DT Article ID PIPE-FLOW; TURBULENT VELOCITY C1 UNIV VIRGINIA,DEPT ENVIRONM SCI,CHARLOTTESVILLE,VA 22903. UNIV WASHINGTON,SCH OCEANOG,SEATTLE,WA 98195. RP LONG, CE (reprint author), USA,COAST ENGN RES CTR,FAC FIELD RES,ENGN WTRWAYS EXPT STN,SR BOX 271,KITTY HAWK,NC 27949, USA. NR 20 TC 27 Z9 27 U1 0 U2 1 PU ASCE-AMER SOC CIVIL ENGINEERS PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-9429 J9 J HYDRAUL ENG-ASCE JI J. Hydraul. Eng.-ASCE PD OCT PY 1993 VL 119 IS 10 BP 1182 EP 1190 DI 10.1061/(ASCE)0733-9429(1993)119:10(1182) PG 9 WC Engineering, Civil; Engineering, Mechanical; Water Resources SC Engineering; Water Resources GA LY590 UT WOS:A1993LY59000008 ER PT J AU EDELMAN, R HOFFMAN, SL DAVIS, JR BEIER, M SZTEIN, MB LOSONSKY, G HERRINGTON, DA EDDY, HA HOLLINGDALE, MR GORDON, DM CLYDE, DF AF EDELMAN, R HOFFMAN, SL DAVIS, JR BEIER, M SZTEIN, MB LOSONSKY, G HERRINGTON, DA EDDY, HA HOLLINGDALE, MR GORDON, DM CLYDE, DF TI LONG-TERM PERSISTENCE OF STERILE IMMUNITY IN A VOLUNTEER IMMUNIZED WITH X-IRRADIATED PLASMODIUM-FALCIPARUM SPOROZOITES SO JOURNAL OF INFECTIOUS DISEASES LA English DT Note ID ATTENUATED SPOROZOITES; MALARIA SPOROZOITES; T-CELLS; IMMUNOGENICITY; VACCINE; PROTEIN; SAFETY; ANTIBODIES; EFFICACY; HUMANS AB Three volunteers were immunized by repeated exposure to the bites of Plasmodium falciparum-infected, X-irradiated mosquitoes to characterize immunologic responses and duration of protective immunity. A primary series of immunizations had been shown previously to induce sterile immunity in these volunteers against sporozoite-induced P. falciparum malaria. In the current study, antibodies to sporozoites circulated at high levels for at least 9-12 months after the volunteers were administered booster bites from X-irradiated infective mosquitoes. One volunteer challenged a second time with P. falciparum 9 months after his last immunization was again shown to be protected, whereas all 5 control subjects developed patent infections. These results set a new standard for persistence of sterile immunity against experimental P. falciparum infection. C1 UNIV MARYLAND,SCH MED,DEPT MED,DIV GEOG MED,BALTIMORE,MD 21201. UNIV MARYLAND,SCH MED,DEPT PEDIAT,DIV INFECT DIS & TROP PEDIAT,BALTIMORE,MD 21201. UNIV MARYLAND,SCH MED,DEPT RADIAT ONCOL,BALTIMORE,MD 21201. USN,MED RES INST,DEPT DEF,MALARIA VACCINE PROGRAM,BETHESDA,MD 20814. WALTER REED ARMY INST RES,DEPT DEF,MALARIA VACCINE PROGRAM,WASHINGTON,DC 20307. BIOMED RES INST,ROCKVILLE,MD. RP EDELMAN, R (reprint author), UNIV MARYLAND,SCH MED,CTR VACCINE DEV,10 S PINE ST,ROOM 9-34,BALTIMORE,MD 21201, USA. FU NIAID NIH HHS [AI-62553] NR 15 TC 62 Z9 62 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD OCT PY 1993 VL 168 IS 4 BP 1066 EP 1070 PG 5 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA LY582 UT WOS:A1993LY58200044 PM 8376823 ER PT J AU RICHARDS, AL MALONE, JD SHERIS, S WEDDLE, JR ROSSI, CA KSIAZEK, TG LEDUC, JW DASCH, GA HYAMS, KC AF RICHARDS, AL MALONE, JD SHERIS, S WEDDLE, JR ROSSI, CA KSIAZEK, TG LEDUC, JW DASCH, GA HYAMS, KC TI ARBOVIRUS AND RICKETTSIAL INFECTIONS AMONG COMBAT TROOPS DURING OPERATION DESERT SHIELD DESERT-STORM SO JOURNAL OF INFECTIOUS DISEASES LA English DT Letter ID TYPHUS C1 USN,INFECT DIS THREAT ASSESSMENT PROGRAM,BETHESDA,MD 20814. USN,DEPT INTERNAL MED,DIV INFECT DIS,VIRAL & RICKETTSIAL DIS PROGRAM,BETHESDA,MD 20814. USA,INFECT DIS RES INST,DIV DIS ASSESSMENT,FREDERICK,MD 21701. NR 9 TC 18 Z9 18 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD OCT PY 1993 VL 168 IS 4 BP 1080 EP 1081 PG 2 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA LY582 UT WOS:A1993LY58200053 PM 8376827 ER PT J AU DOUGHTY, RA AF DOUGHTY, RA TI THE REPUBLIC IN DANGER - GAMELIN,MAURICE AND THE POLITICS OF FRENCH DEFENSE, 1933-1940 - ALEXANDER,MS SO JOURNAL OF MILITARY HISTORY LA English DT Book Review RP DOUGHTY, RA (reprint author), US MIL ACAD,W POINT,NY 10996, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU VIRGINIA MILITARY INST PI LEXINGTON PA LEXINGTON, VA 24450 SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD OCT PY 1993 VL 57 IS 4 BP 728 EP 729 DI 10.2307/2944109 PG 2 WC History SC History GA MC650 UT WOS:A1993MC65000014 ER PT J AU WERNER, ME BACH, DE NEWHOUSE, RF AF WERNER, ME BACH, DE NEWHOUSE, RF TI A COMPARISON OF PROPOFOL WITH METHOHEXITAL AND ISOFLURANE IN 2 GENERAL ANESTHETIC TECHNIQUES SO JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY LA English DT Article ID INDUCTION; MAINTENANCE; FORMULATION; EMULSION; DIPRIVAN C1 TRIPLER ARMY MED CTR,DEPT ORAL & MAXILLOFACIAL SURG,TRIPLER,HI. NR 18 TC 9 Z9 9 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0278-2391 J9 J ORAL MAXIL SURG JI J. Oral Maxillofac. Surg. PD OCT PY 1993 VL 51 IS 10 BP 1076 EP 1079 PG 4 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA MC026 UT WOS:A1993MC02600004 PM 8410445 ER PT J AU SINGH, G ONEAL, RB BRENNAN, WA STRONG, SL HORNER, JA VANDYKE, TE AF SINGH, G ONEAL, RB BRENNAN, WA STRONG, SL HORNER, JA VANDYKE, TE TI SURGICAL-TREATMENT OF INDUCED PERI-IMPLANTITIS IN THE MICRO PIG - CLINICAL AND HISTOLOGICAL ANALYSIS SO JOURNAL OF PERIODONTOLOGY LA English DT Article DE DENTAL IMPLANTS; GUIDED TISSUE REGENERATION; OSSEOINTEGRATION; SURGICAL FLAPS; MEMBRANES, BARRIER; POLYTETRAFLUOROETHYLENE/THERAPEUTIC USE ID ATTACHMENT FORMATION; TISSUE REGENERATION AB THE PURPOSE OF THIS PILOT STUDY was to determine if lost osseous support adjacent to root form implants could be regenerated using a guided tissue regeneration technique. Three fixtures were placed in each edentulous mandibular bicuspid region of two micro pigs. A total of 6 fixtures were placed in each pig. Due to the presence of a pathologic condition, which was in no way related to the research, the results of one pig were not evaluated. Following osseointegration, peri-implantitis was induced by the use of ligatures and a soft diet. Three modalities of treatment were performed. Utilizing a surgical flap approach, one third of the fixtures (one per quadrant) were covered with expanded polytetrafluoroethylene (ePTFE) membrane and submerged under the soft tissue complex. The second group of fixtures were submerged under the soft tissue complex with no ePTFE membrane. The control fixtures along with their abutments were debrided and remained non-submerged. All fixtures were debrided using an air-abrasive polishing system. The osseous defects around the fixtures were measured from a fixed reference point at the time of surgery and after obtaining block sections. At euthanasia, 12 weeks after surgery, block sections of fixtures were removed, fixed, dehydrated, embedded, sectioned, and prepared for SEM analysis. The clinical results showed a decrease in the depth of osseous defects adjacent to fixtures submerged with a ePTFE membrane. There was a gain of up to 5 mm of bone coronally (mean = 2.13 mm). Histologically, from the base of the defect, 35.6% of the regenerated bone fill was osseointegrated, the remaining 64.4% of the regenerated bone fill had a soft tissue interface between bone and fixture. Fixtures that were submerged without an ePTFE membrane gained up to 3 mm of bone coronally (mean = 1.37 mm) with minimal osseointegration (7.8%). The control specimens exhibited minimal gain in bone height (0.87 mm) with no osseointegration. The data suggest that root form fixtures with peri-implantitis may be treated with an ePTFE membrane covered by soft tissue. C1 USA,DENT ACT,FT LEONARD WOOD,MO. UNIV MICHIGAN,SCH DENT,PERIODONT RESIDENCY PROGRAM,ANN ARBOR,MI 48109. USA,DENT ACT,LANDSTUHL,GERMANY. EISENHOWER ARMY MED CTR,DEPT CLIN INVEST,FT GORDON,GA. EASTMAN DENT CTR,DEPT PERIODONT,ROCHESTER,NY. RP SINGH, G (reprint author), USA,DENT ACT,PERIODONT RESIDENCY PROGRAM,FT GORDON,GA 30905, USA. NR 31 TC 51 Z9 52 U1 0 U2 1 PU AMER ACAD PERIODONTOLOGY PI CHICAGO PA 737 NORTH MICHIGAN AVENUE, SUITE 800, CHICAGO, IL 60611-2690 SN 0022-3492 J9 J PERIODONTOL JI J. Periodont. PD OCT PY 1993 VL 64 IS 10 BP 984 EP 989 PG 6 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA MH997 UT WOS:A1993MH99700011 PM 8277409 ER PT J AU FAMINI, GR WILSON, LY AF FAMINI, GR WILSON, LY TI USING THEORETICAL DESCRIPTORS IN STRUCTURE-ACTIVITY-RELATIONSHIPS - SOLUBILITY IN SUPERCRITICAL CO2 SO JOURNAL OF PHYSICAL ORGANIC CHEMISTRY LA English DT Article ID SOLVATION ENERGY RELATIONSHIPS; SOLVATOCHROMIC PARAMETERS; BIOLOGICAL MEDIA; PI-STAR; MOLECULES; ALPHA; SOLVENTS; WATER; BETA; MNDO AB The use of quantitative structure-activity relationships (QSAR) in correlating biological phenomena to chemical structure, and the use of linear free energy relationships (LFER) and linear solvation energy relationships (LSER) for correlating physical phenomena are becoming standard occurrences. In this work the empirical LSER solvatochromic descriptors were replaced with a computationally derived set to ald in a priori property prediction. This paper deals with the application of this descriptor set to correlating the solubilities of 22 compounds in super critical CO2. A reasonable correlation, consistent with previous correlations by other researchers, was found. C1 LA SIERRA UNIV,DEPT CHEM,RIVERSIDE,CA 92515. RP FAMINI, GR (reprint author), USA,EDGEWOOD RES,CTR DEV & ENGN,SCBRD-RT BLDG E3160,ABERDEEN PROVING GROUND,MD 21010, USA. NR 54 TC 16 Z9 16 U1 1 U2 3 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0894-3230 J9 J PHYS ORG CHEM JI J. Phys. Org. Chem. PD OCT PY 1993 VL 6 IS 10 BP 539 EP 544 DI 10.1002/poc.610061002 PG 6 WC Chemistry, Organic; Chemistry, Physical SC Chemistry GA MD728 UT WOS:A1993MD72800001 ER PT J AU GARY, JJ DONOVAN, M AF GARY, JJ DONOVAN, M TI RETENTION DESIGNS FOR BONE-ANCHORED FACIAL PROSTHESES SO JOURNAL OF PROSTHETIC DENTISTRY LA English DT Article ID IMPLANTS; EXPERIENCE AB A facial prosthesis can be retained by bone-anchored implants and by a retentive bar. Because tissue response is critical around the abutments, the retentive bar should be constructed so that it is comfortable, conveniently hygienic, and designed without compromising the contours of the prosthesis. C1 WILLIAM BEAUMONT ARMY MED CTR,FT BLISS,TX. NR 7 TC 19 Z9 19 U1 1 U2 1 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0022-3913 J9 J PROSTHET DENT JI J. Prosthet. Dent. PD OCT PY 1993 VL 70 IS 4 BP 329 EP 332 DI 10.1016/0022-3913(93)90217-C PG 4 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA LZ653 UT WOS:A1993LZ65300011 PM 8229884 ER PT J AU LEEK, MR SUMMERS, V AF LEEK, MR SUMMERS, V TI THE EFFECT OF TEMPORAL WAVE-FORM SHAPE ON SPECTRAL DISCRIMINATION BY NORMAL-HEARING AND HEARING-IMPAIRED LISTENERS SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Article ID BASILAR-MEMBRANE; AUDITORY-NERVE; FINE-STRUCTURE; RESPONSES; 2-TONE; COCHLEA AB A listener's ability to discriminate differences in amplitude spectra is generally thought to be independent of the temporal waveform shapes of the stimuli. However, there have been reports of enhanced contrast between spectral peaks and valleys of harmonic complexes represented in the temporal firing patterns of auditory-nerve fibers for some combinations of component amplitudes and phases [e.g., Horst et al., J. Acoust. Soc. Am. 88, 2656-2681 (1990)]. The enhancement has been attributed to nonlinear processing of high-amplitude peaked waveforms. To determine whether such enhancements are observed in psychoacoustic responses of human listeners, subjects were asked to discriminate between harmonic complexes that differed in the frequency location of three formantlike increments in harmonic amplitude. The stimuli were constructed to have either a very flat or a very peaked temporal envelope. Over a range of 1- to 10-dB spectral contrast between elevated harmonics and background harmonics, discrimination ability was determined as a function of waveform shape and overall amplitude. Performance was measured for both normal-hearing and hearing-impaired listeners. Normal-hearing listeners showed lower thresholds of spectral contrast for peaked waveforms at high intensities than for any of the other phase-amplitude conditions. Although the effect was small (1 to 2 dB), it is consistent with an hypothesized enhancement due to nonlinear cochlear processing. Hearing-impaired listeners did not demonstrate differential performance across phase or amplitude conditions, perhaps reflecting more linear processing in these damaged ears. RP LEEK, MR (reprint author), WALTER REED ARMY MED CTR,ARMY AUDIOL & SPEECH CTR,WASHINGTON,DC 20307, USA. FU NIDCD NIH HHS [DC 60626] NR 18 TC 11 Z9 11 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0001-4966 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD OCT PY 1993 VL 94 IS 4 BP 2074 EP 2082 DI 10.1121/1.407480 PG 9 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA MB552 UT WOS:A1993MB55200016 PM 8227749 ER PT J AU SMITH, KJ SKELTON, HG HEIMER, W BAXTER, D ANGRITT, P FRISMAN, D WAGNER, KF AF SMITH, KJ SKELTON, HG HEIMER, W BAXTER, D ANGRITT, P FRISMAN, D WAGNER, KF TI MELANOCYTIC ACTIVATION IN HIV-1 DISEASE - HMB-45 STAINING IN COMMON ACQUIRED NEVI SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Article ID TUMOR-NECROSIS-FACTOR; NEUROPEPTIDE ALPHA-MSH; MONOCLONAL-ANTIBODIES; STIMULATING HORMONE; DYSPLASTIC NEVI; INFECTION; AIDS; IL-6 AB Background: An increase in pigmented lesions has been reported in HIV-1-infected patients. In a study of HIV-1-positive patients, we have seen patients who noticed new or changing Pigmented lesions. Objective: The goal of this study was to determine to what degree these pigmented lesions showed evidence of significant melanocytic proliferation as opposed to increased pigment production without significant melanocytic proliferation. Methods: Biopsy specimens were studied with routine light microscopy and immunohistochemical stains including S-100 protein, HMB-45, and proliferating cell nuclear antigen. Results: The lesions included two malignant melanomas and 42 benign melanocytic lesions. Significant staining of dermal melanocytes with HMB-45 was present in two of three melanomas and in 19 of 42 nevi. With stains for proliferating cell nuclear antigen there was a positive reaction in the dermal component of both melanomas and a negative reaction in the dermal cells of the nevi. Conclusion: In some HIV-1-infected patients there is stimulation of melanosome production without significant melanocyte proliferation. C1 NATL NAVAL MED CTR, AIDS REGISTRY, BETHESDA, MD 20814 USA. HENRY M JACKSON FDN, WASHINGTON, DC USA. WALTER REED ARMY INST RES, WASHINGTON, DC 20307 USA. NATL NAVAL MED CTR, DEPT CELLULAR PATHOL, BETHESDA, MD 20814 USA. WALTER REED ARMY MED CTR, DEPT DERMATOL, WASHINGTON, DC 20307 USA. RP SMITH, KJ (reprint author), NATL NAVAL MED CTR, DEPT DERMATOL, BETHESDA, MD 20814 USA. FU NIADDK NIH HHS [NIAMS YOIAR00014, NIAMS YOIAR90008] NR 25 TC 12 Z9 14 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD OCT PY 1993 VL 29 IS 4 BP 539 EP 544 PG 6 WC Dermatology SC Dermatology GA MA281 UT WOS:A1993MA28100002 PM 7691905 ER PT J AU KIM, FD CELI, R TISCHLER, MB AF KIM, FD CELI, R TISCHLER, MB TI HIGH-ORDER STATE-SPACE SIMULATION-MODELS OF HELICOPTER FLIGHT MECHANICS SO JOURNAL OF THE AMERICAN HELICOPTER SOCIETY LA English DT Article AB This paper describes the formulation and validation of a high-order linearized mathematical model of helicopter flight mechanics, which includes rotor flap and lag degrees of freedom as well as inflow dynamics. The model is extracted numerically from an existing nonlinear, blade element, real-time simulation model. Extensive modifications in the formulation and solution process of the nonlinear model, required for a theoretically rigorous linearization, are described in detail. The validation results show that the linearized model successfully captures the coupled rotor-fuselage dynamics in the frequency band most critical for the design of advanced flight control systems. Additional results quantify the extent to which the order of the model can be reduced without loss of fidelity. C1 UNIV MARYLAND,DEPT AEROSP ENGN,CTR ROTORCRAFT EDUC & RES,COLL PK,MD 20742. USA,AEROFLIGHTDYNAM DIRECTORATE,AMES RES CTR,MOFFETT FIELD,CA. RP KIM, FD (reprint author), NASA,AMES RES CTR,MOFFETT FIELD,CA 94035, USA. NR 25 TC 14 Z9 15 U1 0 U2 1 PU AMER HELICOPTER SOC INC PI ALEXANDRIA PA 217 N WASHINGTON ST, ALEXANDRIA, VA 22314 SN 0002-8711 J9 J AM HELICOPTER SOC JI J. Am. Helicopter Soc. PD OCT PY 1993 VL 38 IS 4 BP 16 EP 27 PG 12 WC Engineering, Aerospace SC Engineering GA MV901 UT WOS:A1993MV90100002 ER PT J AU NIXON, MW AF NIXON, MW TI PARAMETRIC STUDIES FOR TILTROTOR AEROELASTIC STABILITY IN HIGH-SPEED FLIGHT SO JOURNAL OF THE AMERICAN HELICOPTER SOCIETY LA English DT Article AB The influence of several system design parameters on tiltrotor aeroelastic stability is examined for the highspeed (axial) flight mode. The results are based on a math model in which the wing is assumed to be cantilevered and is represented by beam finite elements having vertical bending, chordwise bending and torsional degrees of freedom. A quasi-steady aerodynamic model is used for both the wing and rotor system. Coupling of the rotor flapping modes with the wing elastic modes produces a whirl motion, typical of tiltrotors, that can become unstable at high speeds. The sensitivity of this instability with respect to rotor frequencies, wing stiffnesses and forward wing sweep is examined. Some important new trends are identified regarding the role of blade lag dynamics and forward wing sweep in tiltrotor aeroelastic stability. Two important conclusions based on these trend studies are that the blade lag frequency may be tuned to improve tiltrotor stability, and forward wing sweep is destabilizing because of changes in rotor force components associated with the sweep. RP NIXON, MW (reprint author), NASA,LANGLEY RES CTR,USA,VEHICLE STRUCT DIRECTORATE,HAMPTON,VA 23665, USA. NR 19 TC 8 Z9 9 U1 0 U2 0 PU AMER HELICOPTER SOC INC PI ALEXANDRIA PA 217 N WASHINGTON ST, ALEXANDRIA, VA 22314 SN 0002-8711 J9 J AM HELICOPTER SOC JI J. Am. Helicopter Soc. PD OCT PY 1993 VL 38 IS 4 BP 71 EP 79 PG 9 WC Engineering, Aerospace SC Engineering GA MV901 UT WOS:A1993MV90100007 ER PT J AU STAMP, GL AF STAMP, GL TI HURRICANE-ANDREW - THE IMPORTANCE OF COORDINATED RESPONSE SO JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION LA English DT Article RP STAMP, GL (reprint author), USA, VET CORPS, FT SAM HOUSTON, TX 78234 USA. NR 3 TC 2 Z9 2 U1 1 U2 1 PU AMER VETERINARY MEDICAL ASSOC PI SCHAUMBURG PA 1931 N MEACHAM RD SUITE 100, SCHAUMBURG, IL 60173-4360 USA J9 J AM VET MED ASSOC JI J. Am. Vet. Med. Assoc. PD OCT 1 PY 1993 VL 203 IS 7 BP 989 EP 992 PG 4 WC Veterinary Sciences SC Veterinary Sciences GA MA069 UT WOS:A1993MA06900024 PM 8226268 ER PT J AU CAMPBELL, J IACONOCONNORS, L WALZ, S SCHULTZ, W AF CAMPBELL, J IACONOCONNORS, L WALZ, S SCHULTZ, W TI THE LANGAT MODEL FOR TICK-BORNE ENCEPHALITIS-VIRUS - SPECIFIC DETECTION BY RT-PCR SO JOURNAL OF VIROLOGICAL METHODS LA English DT Article DE LANGAT; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TICK-BORNE ENCEPHALITIS ID STRUCTURAL PROTEINS; FLAVIVIRUSES; SEQUENCE; AMPLIFICATION; INVITRO; DNA AB We have developed a reverse-transcriptase polymerase chain reaction assay for rapid detection of Langat (LGT) virus, a flavivirus that is closely related to the highly pathogenic tick-borne encephalitis (TBE) viruses. Unlike TBE viruses, LGT virus exhibits a significantly lower virulence for man. The assay serves as a safe alternative for the development and optimization of specific assays for the highly pathogenic subtypes of TBE viruses that are endemic throughout much of Europe, the former Soviet Union, and China. C1 USN,RES LAB,CTR BIOMOLEC SCI,CODE 6900,WASHINGTON,DC 20375. USA,MED RES INST INFECT DIS,FREDERICK,MD 21701. NR 13 TC 6 Z9 6 U1 0 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-0934 J9 J VIROL METHODS JI J. Virol. Methods PD OCT PY 1993 VL 44 IS 2-3 BP 235 EP 240 DI 10.1016/0166-0934(93)90058-Y PG 6 WC Biochemical Research Methods; Biotechnology & Applied Microbiology; Virology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Virology GA ME006 UT WOS:A1993ME00600009 PM 7505284 ER PT J AU GREEN, S KURANE, I EDELMAN, R TACKET, CO ECKELS, KH VAUGHN, DW HOKE, CH ENNIS, FA AF GREEN, S KURANE, I EDELMAN, R TACKET, CO ECKELS, KH VAUGHN, DW HOKE, CH ENNIS, FA TI DENGUE VIRUS-SPECIFIC HUMAN CD4+ T-LYMPHOCYTE RESPONSES IN A RECIPIENT OF AN EXPERIMENTAL LIVE-ATTENUATED DENGUE VIRUS TYPE-1 VACCINE - BULK CULTURE PROLIFERATION, CLONAL ANALYSIS, AND PRECURSOR FREQUENCY DETERMINATION SO JOURNAL OF VIROLOGY LA English DT Article ID INTERFERON GAMMA-PRODUCTION; CELL CLONES; ANTIGENS AB We analyzed the CD4+ T-lymphocyte responses to dengue, West Nile, and yellow fever viruses 4 months after immunization of a volunteer with an experimental live-attenuated dengue virus type 1 vaccine (DEN-1 45AZ51. We examined bulk culture proliferation to noninfectious antigens, determined the precursor frequency of specific CD4+ T cells by limiting dilution, and established and analyzed CD4+ T-cell clones. Bulk culture proliferation was predominantly dengue virus type 1 specific with a lesser degree of cross-reactive responses to other dengue virus serotypes, West Nile virus, and yellow fever virus. Precursor frequency determination by limiting dilution in the presence of noninfectious dengue virus antigens revealed a frequency of antigen-reactive cells of 1 in 1,686 peripheral blood mononuclear cells (PBMC) for dengue virus type 1, 1 in 9,870 PBMC for dengue virus type 3, 1 in 14,053 PBMC for dengue virus type 2, and 1 in 17,690 PBMC for dengue virus type 4. Seventeen CD4+ T-cell clones were then established by using infectious dengue virus type 1 as antigen. Two patterns of dengue virus specificity were found in these clones. Thirteen clones were dengue virus type 1 specific, and four clones recognized both dengue virus types 1 and 3. Analysis of human leukocyte antigen (HLA) restriction revealed that five clones are HLA-DRw52 restricted, one clone is HLA-DP3 restricted, and one clone is HLA-DP4 restricted. These results indicate that in this individual, the CD4+ T-lymphocyte responses to immunization with live-attenuated dengue virus type 1 vaccine are predominantly serotype specific and suggest that a multivalent vaccine may be necessary to elicit strong serotype-cross-reactive CD4+ T-lymphocyte responses in such individuals. C1 UNIV MASSACHUSETTS,MED CTR,DEPT MED,DIV DIS & IMMUNOL,WORCESTER,MA 01605. UNIV MARYLAND,CTR VACCINE DEV,BALTIMORE,MD 21201. WALTER REED ARMY INST RES,DEPT VIRAL DIS,WASHINGTON,DC 20307. WALTER REED ARMY INST RES,DEPT BIOL RES,WASHINGTON,DC 20307. FU NIAID NIH HHS [R01-AI30624]; PHS HHS [T32-A107272] NR 18 TC 50 Z9 51 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0022-538X J9 J VIROL JI J. Virol. PD OCT PY 1993 VL 67 IS 10 BP 5962 EP 5967 PG 6 WC Virology SC Virology GA LX120 UT WOS:A1993LX12000031 PM 8371350 ER PT J AU SWEARENGEN, JR COCKMANTHOMAS, RA DAVIS, JA WEINA, PJ AF SWEARENGEN, JR COCKMANTHOMAS, RA DAVIS, JA WEINA, PJ TI EVALUATION OF BUTORPHANOL TARTRATE AND BUPRENORPHINE HYDROCHLORIDE ON THE INFLAMMATORY REACTION OF THE SERENY TEST SO LABORATORY ANIMAL SCIENCE LA English DT Article ID VACCINE AB Invasion of the ocular epithelia of guinea pigs by virulent Shigella organisms, eliciting keratoconjunctivitis, is the basis of the Sereny Test (ST). This test has been used to ascertain the virulence of Shigella strains and more recently to screen candidate Shigella vaccines for efficacy. This test undoubtedly causes pain in test animals; however, recommendation for use of local analgesics/anesthetics has not been accepted because of concern that these topical agents may affect the ability of the Shigella organisms to invade the ocular epithelia or have a physiologic effect on the inflammatory process. Similarly, investigators are hesitant to use systemic analgesics in conjunction with the ST. Two blinded studies were conducted to evaluate the effects of selected systemic analgesics on the ST in outbred Hartley guinea pigs. Study 1 evaluated the recommended dosages for two systemic analgesics; study groups consisted of those receiving butorphanol tartrate (n = 16), those receiving buprenorphine hydrochloride (n = 16), and untreated controls (n = 5). Study 2 evaluated. a low-dose buprenorphine hydrochloride group (n = 16) and an untreated control group (n = 5). All animals were inoculated with Shigella flexneri, strain 2a 2457T, onto the cornea and conjunctiva of each eye. At the onset of clinical signs, analgesics were administered to test groups. The degree of keratoconjunctivitis was evaluated per standard procedure; animals were weighed daily. After 7 days, animals were euthanatized and the eyes were removed for histologic morphometric evaluation. Clinical observations of keratoconjunctivitis in both studies were not significantly different. Histologic morphometry confirmed clinical observations when each analgesic treatment group was compared with the corresponding untreated control group. Mean individual weight gains were less in all analgesic groups when compared with their untreated control group and were attributed to opioid-induced sedation. Our findings suggest that agonist-antagonist opioid analgesics do not interfere with the inflammatory response of the ST. Although heavy buildup of periorbital mucopurulent discharge in the buprenorphine study-I group complicated clinical observations, the lower dose of buprenorphine (study 2) appears compatible for use with the ST, on the basis of noninterference with the inflammatory reaction, logistical advantages over butorphanol, and minimal interference with making clinical observations. RP SWEARENGEN, JR (reprint author), WALTER REED ARMY INST RES,DIV VET MED,WASHINGTON,DC 20307, USA. NR 15 TC 2 Z9 2 U1 0 U2 1 PU AMER ASSOC LABORATORY ANIMAL SCIENCE PI CORDOVA PA 70 TIMBERCREEK DR, SUITE 5, CORDOVA, TN 38018 SN 0023-6764 J9 LAB ANIM SCI JI Lab. Anim. Sci. PD OCT PY 1993 VL 43 IS 5 BP 471 EP 475 PG 5 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA MF111 UT WOS:A1993MF11100015 PM 8277729 ER PT J AU PARLETT, WR GEORGE, TF BLEY, JA AF PARLETT, WR GEORGE, TF BLEY, JA TI A PARAMEDIAN RETROPERITONEAL APPROACH TO THE KIDNEY AND URETER IN PIGS SO LABORATORY ANIMAL SCIENCE LA English DT Article C1 WALTER REED ARMY MED CTR,ARMED FORCES INST PATHOL,DIV LAB ANIM MED,WASHINGTON,DC 20306. RP PARLETT, WR (reprint author), UNIFORMED SERV UNIV HLTH SCI,F EDWARD HEBERT SCH MED,DEPT LAB ANIM MED,4301 JONES BRIDGE RD,BETHESDA,MD 20814, USA. NR 2 TC 1 Z9 1 U1 1 U2 1 PU AMER ASSOC LABORATORY ANIMAL SCIENCE PI CORDOVA PA 70 TIMBERCREEK DR, SUITE 5, CORDOVA, TN 38018 SN 0023-6764 J9 LAB ANIM SCI JI Lab. Anim. Sci. PD OCT PY 1993 VL 43 IS 5 BP 520 EP 523 PG 4 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA MF111 UT WOS:A1993MF11100029 PM 8277743 ER PT J AU BARTH, J AF BARTH, J TI COLLISION - GM, TOYOTA, VOLKSWAGEN, AND THE RACE TO OWN THE 21ST-CENTURY - KELLER,M SO LIBRARY JOURNAL LA English DT Book Review RP BARTH, J (reprint author), US MIL ACAD,W POINT,NY 10996, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 SN 0363-0277 J9 LIBR J JI Libr. J. PD OCT 1 PY 1993 VL 118 IS 16 BP 106 EP & PG 0 WC Information Science & Library Science SC Information Science & Library Science GA LZ834 UT WOS:A1993LZ83400130 ER PT J AU BURGESS, EB AF BURGESS, EB TI SHADOW OVER BABYLON - MASON,D SO LIBRARY JOURNAL LA English DT Book Review RP BURGESS, EB (reprint author), USA,CTR TRALINET,FT MONROE,VA, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 SN 0363-0277 J9 LIBR J JI Libr. J. PD OCT 1 PY 1993 VL 118 IS 16 BP 127 EP 127 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA LZ834 UT WOS:A1993LZ83400213 ER PT J AU POLLAK, FH SHEN, H AF POLLAK, FH SHEN, H TI MODULATION SPECTROSCOPY OF SEMICONDUCTORS - BULK THIN-FILM, MICROSTRUCTURES, SURFACES INTERFACES AND DEVICES SO MATERIALS SCIENCE & ENGINEERING R-REPORTS LA English DT Review ID MULTIPLE QUANTUM-WELLS; MOLECULAR-BEAM EPITAXY; FRANZ-KELDYSH OSCILLATIONS; STRAINED-LAYER SUPERLATTICES; VAPOR-PHASE-EPITAXY; DELTA-DOPED GAAS; 001 N-TYPE; DIFFERENTIAL REFLECTANCE SPECTROSCOPY; ROOM-TEMPERATURE ELECTROREFLECTANCE; ELECTRIC-FIELD DISTRIBUTIONS AB Modulation spectroscopy is a powerful method for the study and characterization of a large number of semiconductor configurations, including bulk/thin film, microstructures (heterojunctions, quantum wells, superlattices, quantum dots), surfaces/interfaces and actual device structures in addition to semiconductor growth/processing. Furthermore, the influence of external perturbations such as temperature, electric fields, hydrostatic pressure, uniaxial stress, etc. can be investigated. This optical technique utilizes a very general principle of experimental physics, in which a periodically applied perturbation (either to the sample or probe) leads to sharp, derivative-like spectral features in the optical response of the system. Because of the richness of the derivative-like spectra, the information in the lineshape fits, room temperature performance and relative simplicity of operation this method is becoming increasingly more important as a tool to study these materials and structures. This article will review developments in the field during the last decade. C1 USA,RES LAB,ELECTR & POWER SOURCES DIRECTORATE,AMSRL EP EF,FT MONMOUTH,NJ 07703. GEOCENTERS INC,LAKE HOPATCONG,NJ 07849. RP POLLAK, FH (reprint author), CUNY BROOKLYN COLL,DEPT PHYS,BROOKLYN,NY 11210, USA. NR 475 TC 359 Z9 359 U1 3 U2 42 PU ELSEVIER SCIENCE SA LAUSANNE PI LAUSANNE 1 PA PO BOX 564, 1001 LAUSANNE 1, SWITZERLAND SN 0927-796X J9 MAT SCI ENG R JI Mater. Sci. Eng. R-Rep. PD OCT 1 PY 1993 VL 10 IS 7-8 BP 275 EP 374 PG 100 WC Materials Science, Multidisciplinary; Physics, Applied SC Materials Science; Physics GA LZ089 UT WOS:A1993LZ08900001 ER PT J AU HII, JLK KANAI, L FOLIGELA, A KAN, SKP BURKOT, TR WIRTZ, RA AF HII, JLK KANAI, L FOLIGELA, A KAN, SKP BURKOT, TR WIRTZ, RA TI IMPACT OF PERMETHRIN-IMPREGNATED MOSQUITO NETS COMPARED WITH DDT HOUSE-SPRAYING AGAINST MALARIA TRANSMISSION BY ANOPHELES-FARAUTI AND AN-PUNCTULATUS IN THE SOLOMON-ISLANDS SO MEDICAL AND VETERINARY ENTOMOLOGY LA English DT Article ID LINKED IMMUNOSORBENT-ASSAY; PLASMODIUM-FALCIPARUM; INFECTED MOSQUITOS; IDENTIFICATION; VIVAX AB In villages of northern Guadalcanal in the Solomon Islands, where the predominant malaria vector is An.farauti No. 1 and An.puctulatus is also involved, malaria transmission rates were compared for three zones: (1) non-intervention: 438 people in seventeen villages; (2) residual DDT house-spraying two cycles per year: 644 people in thirty villages; (3) bednets impregnated with permethrin 0.5 g/m2 twice per year, used by 580 people in sixteen villages. Regular DDT spraying in zones 1 and 3 had been withdrawn 18 months previously. Malariological blood smear surveys of children aged 1-9 years in August 1986 to January 1987 showed a mean-baseline malaria parasite rate of 38% (32/84). By February 1988, 18 months after introduction of impregnated bednets, the Plasmodium falciparum infection rate in children was lowest in the zone using impregnated bednets (21% of 29), intermediate in the untreated zone (29% of 34) and highest in the DDT zone (46% of 53), but these differences were not statistically significant. P.vivax infection rates were 9-14%. Using ELISA tests for malaria circumsporozoite antigen in the vectors, overall positivity rates were 0.7% of 49,902 An.farauti and 2.54% of 118 An.punctulatus, comprising 228 P.falciparum and 124 P. vivax infections. In the study zones, vector positivity rates were 0.93% of 31,615 An.farauti in the untreated zone; 0.32% of 16,883 An.farauti in the DDT zone; 0.07% of 1404 An.farauti and 2.54% of 118 An.puctulatus in the impregnated bednet zone. There was no significant correlation between malaria parasite rates in the vectors and the children. Entomological inoculation rates were consistently highest in the untreated zone (1.6-2.8 infective bites/night), intermediate in the DDT zone (0.8- 1. 1/night) and significantly lowest in the bednet zone (0.03-0.23/night). Geometric mean densities of P.falciparum sporozoites were also significantly higher in the DDT zone (50% > 10,000 sporozoites/mosquito compared with 20% in untreated zone). The highest individual infection density was an estimated 52,080 sporozoites of P.falciparum in a specimen of An.punctulatus from the bednet zone. P.vivax sporozoite densities were not significantly different between zones, and both species of vector had similar mean sporozoite loads for both species of malaria. It is concluded that permethrin-impregnated mosquito nets exerted significantly more impact on vector infectivity and the inoculation rate than resulted from DDT spraying. Even so, the inoculation rate for people in the bednet zone remained at one infective bite every 4-32 days, an insufficient reduction to control malaria without additional countermeasures. Ineffectiveness of house-spraying and the limited impact of impregnated bednets are attributed to exophily and other behavioural aspects of An.farauti. C1 WALTER REED ARMY INST RES,DEPT ENTOMOL,WASHINGTON,DC 20307. MINIST HLTH & MED SCI,ANTI MALARIA PROGRAMME,HONIARA,SOLOMON ISLANDS. QUEEN ELIZABETH HOSP,CENT MED LAB,SABAH,MALAYSIA. QUEENSLAND INST MED RES,BRISBANE,QLD,AUSTRALIA. RP HII, JLK (reprint author), PAPUA NEW GUINEA INST MED RES,POB 378,MADANG,PAPUA N GUINEA. RI Burkot, Thomas/C-6838-2013 NR 28 TC 45 Z9 45 U1 2 U2 5 PU BLACKWELL SCIENCE LTD PI OXFORD PA OSNEY MEAD, OXFORD, OXON, ENGLAND OX2 0EL SN 0269-283X J9 MED VET ENTOMOL JI Med. Vet. Entomol. PD OCT PY 1993 VL 7 IS 4 BP 333 EP 338 DI 10.1111/j.1365-2915.1993.tb00701.x PG 6 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA LY803 UT WOS:A1993LY80300005 PM 8268487 ER PT J AU PERICH, MJ TIDWELL, MA DOBSON, SE SARDELIS, MR ZAGLUL, A WILLIAMS, DC AF PERICH, MJ TIDWELL, MA DOBSON, SE SARDELIS, MR ZAGLUL, A WILLIAMS, DC TI BARRIER SPRAYING TO CONTROL THE MALARIA VECTOR ANOPHELES-ALBIMANUS - LABORATORY AND FIELD-EVALUATION IN THE DOMINICAN-REPUBLIC SO MEDICAL AND VETERINARY ENTOMOLOGY LA English DT Article DE ANOPHELES-ALBIMANUS; EXOPHILY; BARRIER SPRAYING; MALARIA CONTROL; ULTRA-LOW VOLUME; BENDIOCARB; MALATHION; PERMETHRIN; DELTAMETHRIN; DOMINICAN-REPUBLIC ID MOSQUITOS; PERMETHRIN; CULICIDAE; FOLIAGE; DIPTERA AB To develop a new strategy for control of exophilic/exophagic malaria vectors which rest on peridomestic foliage, Anopheles albimanus was used for laboratory bioassays of mosquito adulticides applied to various vegetation types. Of the three classes of insecticide tested, the pyrethroid (permethrin at 112 g/ha) showed greater foliar persistence than either the carbamate (bendiocarb at 340 g/ha) or the organophosphorus compound (malathion at 277 g/ha). Field evaluation of barrier spraying against An.albimanus was evaluated in rural villages of southwest Dominican Republic during 1989. The pyrethroid deltamethrin was sprayed aerially for ultra-low volume application at treatment rates of 17-19 g a.i./ha in a radius of 500 m around two villages. An.albimanus were monitored by light-traps and human bait collections at both treated villages, compared with two similar untreated villages, up to 9 nights post-treatment. Densities of female An.albimanus were significantly reduced in the sprayed villages for at least 8 or 9 nights. Further evaluation of barrier spraying is recommended to determine optimal pyrethroid formulations and applications rates, their impact on non-target fauna and efficacy against malaria transmission. C1 UNIV S CAROLINA,INT CTR PUBL HLTH RES,MCCLELLANVILLE,SC. USA,BIOMED RES & DEV LAB,FREDERICK,MD 21701. UNIV CATOLICA MADRE & MAESTRA,SANTIAGO,DOMINICAN REP. SERV NACL ERADICAC MALARIA,SANTO DOMINGO,DOMINICAN REP. NR 23 TC 21 Z9 22 U1 0 U2 0 PU BLACKWELL SCIENCE LTD PI OXFORD PA OSNEY MEAD, OXFORD, OXON, ENGLAND OX2 0EL SN 0269-283X J9 MED VET ENTOMOL JI Med. Vet. Entomol. PD OCT PY 1993 VL 7 IS 4 BP 363 EP 368 DI 10.1111/j.1365-2915.1993.tb00706.x PG 6 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA LY803 UT WOS:A1993LY80300010 PM 8268492 ER PT J AU RITCHIE, EC WHITE, R AF RITCHIE, EC WHITE, R TI BECOMING A SUCCESSFUL DIVISION PSYCHIATRIST - GUIDELINES FOR PREPARATION AND DUTIES OF THE ASSIGNMENT SO MILITARY MEDICINE LA English DT Article AB Little attention is given in psychiatry residency programs to preparing graduates to occupy division psychiatry slots. The first part of this paper discusses several guidelines: preparations to make before leaving for a new post; immediate steps to take upon arrival; the place of the Division Mental Health Service in a division structure; and general observations about how best to obtain credibility with line soldiers. The second part focuses on general and specific duties of the assignment, and discusses some common clinical problems. The paper is intended to help the new division psychiatrists have an effective and productive tour. Many sections will be applicable to general medical officers and other health care workers leaving for a division assignment. RP RITCHIE, EC (reprint author), WALTER REED ARMY MED CTR,DEPT PSYCHIAT,WASHINGTON,DC 20307, USA. NR 0 TC 3 Z9 3 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD OCT PY 1993 VL 158 IS 10 BP 644 EP 648 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA MB762 UT WOS:A1993MB76200008 ER PT J AU ZALOZNIK, AJ STINSON, KR RENNIE, DS AF ZALOZNIK, AJ STINSON, KR RENNIE, DS TI IMPACT OF UNITS ON ROTATION AT THE NATIONAL TRAINING-CENTER - THE FORT-IRWIN MEDDAC EXPERIENCE SO MILITARY MEDICINE LA English DT Article AB Soldiers who experience orthopedic injuries during their training cycle at the National Training Center have a major impact on the Fort Irwin MEDDAC. The majority of hospital referrals from the field medical companies and admissions occur during the training days 7 through 20. Vehicular and other training accidents result in a mini-MASCAL at least once during the rotation, requiring the activation of selected MEDDAC personnel. RP ZALOZNIK, AJ (reprint author), USA,HLTH PROFESS SUPPORT AGCY,ATTN HQDA SGPS-CP-M,5109 LEESBURG PIKE,FALLS CHURCH,VA 22041, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD OCT PY 1993 VL 158 IS 10 BP 649 EP 651 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA MB762 UT WOS:A1993MB76200009 PM 8264921 ER PT J AU MEGO, DM PUPA, LE BAILEY, SR AF MEGO, DM PUPA, LE BAILEY, SR TI CLINICAL-EVALUATION OF A RAPID IMMUNOINHIBITION ASSAY FOR CREATINE KINASE-MB IN SUSPECTED MYOCARDIAL-INFARCTION SO MILITARY MEDICINE LA English DT Article AB We examined the clinical performance of a new immunoinhibition assay (INH) for the measurement of creatine kinase isoenzyme MB (CK-MB). In 196 consecutive patients admitted for exclusion of acute myocardial infarction, serial blood samples were evaluated by INH, immunoradiometric assay (IRMA), and electrophoresis (ELP). Using receiver operating characteristic curve analysis, the diagnostic performance of the INH assay was comparable to IRMA and ELP. As compared with these alternative methodologies, this newly available INH assay for CK-MB provides similar diagnostic accuracy and increased convenience at a greatly reduced cost. RP MEGO, DM (reprint author), BROOKE ARMY MED CTR,CARDIOL SERV,FT SAM HOUSTON,TX 78234, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD OCT PY 1993 VL 158 IS 10 BP 651 EP 654 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA MB762 UT WOS:A1993MB76200010 PM 8264922 ER PT J AU CHISICK, MC AF CHISICK, MC TI DENTAL UTILIZATION BY ACTIVE-DUTY ARMY PERSONNEL SO MILITARY MEDICINE LA English DT Article AB In spring 1989, a random, Army-wide sample of 15,364 enlisted and 4,529 officer personnel was surveyed on dental utilization. Results show no difference in annual dental utilization between officer and enlisted personnel when age is controlled. Because annual dental utilization increases with age and enlisted ranks contain a disproportionately large number of younger personnel, a difference in annual dental utilization between enlisted and officer personnel emerges when age is not controlled. Check-ups are the most common reason for dental visits. Nearly all soldiers seek care exclusively in military dental clinics. Non-use is highest among 18- to 19-year-olds (12.2 %). RP CHISICK, MC (reprint author), USA,INST DENT RES,EPIDEMIOL SECT,FT GEORGE G MEADE,MD 20755, USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD OCT PY 1993 VL 158 IS 10 BP 670 EP 673 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA MB762 UT WOS:A1993MB76200015 PM 8264927 ER PT J AU HAINES, ET WEIDENBACH, B AF HAINES, ET WEIDENBACH, B TI PLANNING FOR MEDICAL SUPPORT OF DISASTERS SO MILITARY MEDICINE LA English DT Article AB Disaster health care plans require that planners consider personnel, equipment, supplies (including pharmaceuticals), and logistical support for transportation, food, water, and resupply. The authors believe that military Table of Organization and Equipment (TOE) hospitals have the potential to be invaluable sources of personnel, equipment, and supplies. They recommend that TOE organizations plan Military Mobilization Teams (MMTs) that are lightweight, rapidly deployable, and easily supported. In addition, MMTs can serve as the advance party units around which more complex health care organizations can be developed. The same MTTs have potential military uses such as mobilization in stages. RP HAINES, ET (reprint author), USA,MEDDAC,FT HUACHUCA,AZ 85613, USA. NR 0 TC 6 Z9 8 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD OCT PY 1993 VL 158 IS 10 BP 680 EP 683 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA MB762 UT WOS:A1993MB76200018 PM 8264930 ER PT J AU STOKES, J AF STOKES, J TI PSYCHIATRY AND WAR SO MILITARY MEDICINE LA English DT Letter RP STOKES, J (reprint author), USA,FT SAM HOUSTON,TX 78234, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD OCT PY 1993 VL 158 IS 10 BP A6 EP & PG 0 WC Medicine, General & Internal SC General & Internal Medicine GA MB762 UT WOS:A1993MB76200001 PM 8264916 ER PT J AU WEBER, CR AF WEBER, CR TI WHAT IS SHRAPNEL - RESPONSE SO MILITARY MEDICINE LA English DT Letter RP WEBER, CR (reprint author), USA,WASHINGTON,DC 20310, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD OCT PY 1993 VL 158 IS 10 BP A10 EP A10 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA MB762 UT WOS:A1993MB76200004 ER PT J AU BARR, D WEIR, M HOFFMAN, J AF BARR, D WEIR, M HOFFMAN, J TI AN INDICATOR OF COMBAT SUCCESS SO NAVAL RESEARCH LOGISTICS LA English DT Article AB Assessing the effects of changes in weapons systems or battle tactics is difficult because of the variations in battles and the resulting instability of measures of combat effectiveness. Even under the relatively stable conditions of designed combat exercises, traditional measures may fail to reflect important battle events and dynamics. This variation in results makes the design, conduct, and evaluation of combat experiments, combat simulations, and combat training exercises a challenging endeavor, indeed. We develop and examine a combat measure of effectiveness, based on Lanchester models, which we call the battle trace. The battle trace is a measure of ongoing battle results, measured as a function of time into the battle. We describe how such measures might contribute to assessing effects of changing certain battle parameters. We suggest applications of these ideas to developing combat simulations and to enhancing combat training exercises. (C) 1993 John Wiley & Sons, Inc. C1 USN,SCH POSTGRAD,DEPT MATH,MONTEREY,CA 93943. COLORADO SCH MINES,DEPT MATH,GOLDEN,CO 80401. RP BARR, D (reprint author), US MIL ACAD,DEPT SYST ENGN,W POINT,NY 10996, USA. NR 11 TC 0 Z9 0 U1 0 U2 0 PU JOHN WILEY & SONS INC PI NEW YORK PA 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0894-069X J9 NAV RES LOG JI Nav. Res. Logist. PD OCT PY 1993 VL 40 IS 6 BP 755 EP 768 DI 10.1002/1520-6750(199310)40:6<755::AID-NAV3220400603>3.0.CO;2-L PG 14 WC Operations Research & Management Science SC Operations Research & Management Science GA LY344 UT WOS:A1993LY34400001 ER PT J AU SARNO, AP MOORMAN, AJ KALOUSEK, DK AF SARNO, AP MOORMAN, AJ KALOUSEK, DK TI PARTIAL MOLAR PREGNANCY WITH FETAL SURVIVAL - AN UNUSUAL EXAMPLE OF CONFINED PLACENTAL MOSAICISM SO OBSTETRICS AND GYNECOLOGY LA English DT Article AB Background: A pregnancy with a partial molar placenta and a normal fetus is a rare condition. Few guidelines exist for antenatal evaluation and management, particularly with respect to selecting cases for conservative management. Case: Cytogenetic analysis of chorionic villi showed a triploid placenta, and both amniotic fluid and blood indicated a diploid fetus. The pregnancy resulted in a normal newborn. Conclusion: This disorder appears to be due to confined placental mosaicism. C1 BRITISH COLUMBIA CHILDRENS HOSP,CYTOGENET EMBRYOPATHOL LAB,VANCOUVER,BC,CANADA. RP SARNO, AP (reprint author), TRIPLER ARMY MED CTR,ANTEPARTUM DIAGNOST CTR,MATERNAL FETAL MED SERV,TRIPLER AMC,HI, USA. NR 11 TC 21 Z9 22 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0029-7844 J9 OBSTET GYNECOL JI Obstet. Gynecol. PD OCT PY 1993 VL 82 IS 4 BP 716 EP 719 PN 2 PG 4 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA LY728 UT WOS:A1993LY72800031 PM 8378025 ER PT J AU MADER, TH ARAGONES, JV CHANDLER, AC HAZLEHURST, JA HEIER, J KINGHAM, JD STEIN, E AF MADER, TH ARAGONES, JV CHANDLER, AC HAZLEHURST, JA HEIER, J KINGHAM, JD STEIN, E TI OCULAR AND OCULAR ADNEXAL INJURIES TREATED BY UNITED-STATES MILITARY OPHTHALMOLOGISTS DURING OPERATIONS DESERT SHIELD AND DESERT-STORM SO OPHTHALMOLOGY LA English DT Article; Proceedings Paper CT 1992 ANNUAL MEETING OF THE AMERICAN-ACADEMY-OF-OPHTHALMOLOGY CY NOV, 1992 CL DALLAS, TX SP AMER ACAD OPHTHALMOL ID EYE INJURIES; LEBANON WAR; PROTECTION AB Background. Ocular and ocular adnexal injuries, both combat-related and accidental, are common during wartime. In a combat setting, the eye is particularly vulnerable to serious injury from tiny flying particles that might minimally affect other parts of the body. The purpose of this study is to examine the incidence of serious ocular and ocular adnexal injuries that occurred during Operations Desert Shield and Desert Storm. Methods: The authors retrospectively reviewed serious ocular and ocular adnexal injuries treated by United States Army and Navy ophthalmologists that occurred during Operations Desert Shield and Desert Storm. Only those injuries that resulted in, or would have resulted in, hospital admission because of the ocular or ocular adnexal injury alone are presented. Results: During Desert Shield, 20 patients (23 eyes) suffered serious ocular or ocular adnexal injuries compared with 160 patients (1 98 eyes) in Desert Storm. During Desert Storm, 78% of all serious injuries were caused by blast fragmentation from munitions. More than one third of the 98 globe lacerations reported in this article were 10 mm or less in size. Of 35 enucleations performed during Desert Storm, 94% were the result of munitions fragments. Conclusions: During Operation Desert Storm, fragmentation wounds from munitions were the most common cause of ocular and ocular adnexal morbidity. The authors' findings indicate that polycarbonate ballistic protective eyewear could have prevented many of the ocular injuries that they report. C1 USA,FITZSIMONS ARMY MED CTR,AURORA,CO. USA RESERVE,ROCHESTER,MI. USA RESERVE,DURHAM,NC. USN,CHICO,CA. RP MADER, TH (reprint author), USA,MADIGAN ARMY MED CTR,OPHTHALMOL SERV,TACOMA,WA 98431, USA. NR 11 TC 45 Z9 45 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0161-6420 J9 OPHTHALMOLOGY JI Ophthalmology PD OCT PY 1993 VL 100 IS 10 BP 1462 EP 1467 PG 6 WC Ophthalmology SC Ophthalmology GA MA307 UT WOS:A1993MA30700016 PM 8414405 ER PT J AU BECK, RA KAMBISS, S BASS, JW AF BECK, RA KAMBISS, S BASS, JW TI THE RETREAT OF HAEMOPHILUS-INFLUENZAE TYPE-B INVASIVE DISEASE - ANALYSIS OF AN IMMUNIZATION PROGRAM AND IMPLICATIONS FOR OTO-HNS SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY LA English DT Article ID POLYSACCHARIDE VACCINE; ACUTE EPIGLOTTITIS; UNITED-STATES; CHILDREN; INFECTIONS; MENINGITIS; EPIDEMIOLOGY; PREVENTION AB Hemophilus influenzae type b (Hib) is the most common cause of bacterial meningitis among children under 5 years old. Hib is also responsible for other invasive diseases including epiglottitis, cellulitis, sepsis, pneumonia, and osteomyelitis. A child's cumulative risk of systemic Hib disease during the first 5 years of life is approximately 1 in 200. A polysaccharide Hib vaccine was first marketed in 1985, and newer, more effective conjugated vaccines have been licensed since 1987. Immunization schedules have included increasingly younger children. No studies have been published that analyze the effects of a vigorous immunization program on a sample population representative of the United States at large. Records of pediatric patients ages 5 years and younger who were treated for Hib meningitis or epiglottitis (N = 373) at all U.S. Army medical facilities between 1986 and 1991 were reviewed. The combined incidence of these diseases declined by more than 86% in the study group during this period. The largest decrease occurred in infants less than 1 year old, before vaccines were licensed for use in this group. Meanwhile, the number of cases of bacterial meningitis due to other organisms in this cohort remained unchanged. Economic modeling validates the cost-effectiveness of vaccination. The impact of these preliminary trends on health care systems and otolaryngology-head and neck surgery will be significant. Almost two thirds of Hib disease has involved infants under 15 months old, for whom a conjugated vaccine has been available only since October 1990. The change in disease frequency will have substantial bearing on training programs, because management of neurologic sequelae and the emergent airway require the expertise of otolaryngologists. In the face of medical onslaught, Hib invasive disease is in retreat. C1 DWIGHT D EISENHOWER ARMY MED CTR,OTOLARYNGOL HEAD & NECK SURG SERV,FT GORDON,GA 30905. TRIPLER ARMY MED CTR,DEPT PEDIAT,HONOLULU,HI 96859. NR 26 TC 11 Z9 11 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0194-5998 J9 OTOLARYNG HEAD NECK JI Otolaryngol. Head Neck Surg. PD OCT PY 1993 VL 109 IS 4 BP 712 EP 721 PG 10 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA MF897 UT WOS:A1993MF89700013 PM 8233509 ER PT J AU TEGOSHI, T UDOMSANGPETCH, R BROWN, A NAKAZAWA, S WEBSTER, HK AIKAWA, M AF TEGOSHI, T UDOMSANGPETCH, R BROWN, A NAKAZAWA, S WEBSTER, HK AIKAWA, M TI ULTRASTRUCTURE OF ROSETTE FORMATION BY PLASMODIUM-COATNEYI-INFECTED ERYTHROCYTES OF RHESUS SO PARASITOLOGY RESEARCH LA English DT Note ID HUMAN CEREBRAL MALARIA; RED-BLOOD-CELLS; CYTOADHERENCE; SEQUESTRATION C1 CASE WESTERN RESERVE UNIV,INST PATHOL,CLEVELAND,OH 44106. MAHIDOL UNIV,FAC SCI,DEPT PATHOBIOL,BANGKOK 10700,THAILAND. USA,MED COMPONENT,ARMED FORCES RES INST MED SCI,BANGKOK,THAILAND. FU NIAID NIH HHS [AI-10645] NR 16 TC 10 Z9 10 U1 0 U2 0 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0044-3255 J9 PARASITOL RES JI Parasitol. Res. PD OCT PY 1993 VL 79 IS 7 BP 611 EP 613 DI 10.1007/BF00932248 PG 3 WC Parasitology SC Parasitology GA MB280 UT WOS:A1993MB28000014 PM 8278346 ER PT J AU WISWELL, TE BENT, RC AF WISWELL, TE BENT, RC TI MECONIUM STAINING AND THE MECONIUM ASPIRATION SYNDROME - UNRESOLVED ISSUES SO PEDIATRIC CLINICS OF NORTH AMERICA LA English DT Review ID PERSISTENT PULMONARY-HYPERTENSION; SEVERE RESPIRATORY-FAILURE; AMNIOTIC-FLUID; HIGH-FREQUENCY; PROPHYLACTIC AMNIOINFUSION; SURFACTANT TREATMENT; TRACHEAL SUCTION; FETAL DISTRESS; NITRIC-OXIDE; PIGLET MODEL C1 TRIPLER ARMY MED CTR,DEPT PEDIAT,HONOLULU,HI 96859. RP WISWELL, TE (reprint author), THOMAS JEFFERSON UNIV,DEPT PEDIAT,DIV NEONATOL,1025 WALNUT ST,SUITE 700,PHILADELPHIA,PA 19107, USA. NR 116 TC 131 Z9 134 U1 0 U2 3 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0031-3955 J9 PEDIATR CLIN N AM JI Pediatr. Clin. N. Am. PD OCT PY 1993 VL 40 IS 5 BP 955 EP 981 PG 27 WC Pediatrics SC Pediatrics GA MA095 UT WOS:A1993MA09500005 PM 8414717 ER PT J AU KILKENNY, TE AF KILKENNY, TE TI ACUTE SCROTUM IN AN INFANT - POST-HERNIORRAPHY COMPLICATION - SONOGRAPHIC EVALUATION SO PEDIATRIC RADIOLOGY LA English DT Article AB The complications of herniorraphy mainly involve hematoma and other fluid collections within the scrotum. Discussed here is a case of another post-herniorraphy complication, recurrent scrotal hernia, in an infant who presented with an acute scrotum and was evaluated sonographically. RP KILKENNY, TE (reprint author), TRIPLER ARMY MED CTR,DEPT RADIOL,HONOLULU,HI 96859, USA. NR 4 TC 0 Z9 0 U1 0 U2 0 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0301-0449 J9 PEDIATR RADIOL JI Pediatr. Radiol. PD OCT PY 1993 VL 23 IS 6 BP 481 EP 482 DI 10.1007/BF02012460 PG 2 WC Pediatrics; Radiology, Nuclear Medicine & Medical Imaging SC Pediatrics; Radiology, Nuclear Medicine & Medical Imaging GA MB285 UT WOS:A1993MB28500021 PM 8255659 ER PT J AU KENLEY, RA YIM, K ABRAMS, J RON, E TUREK, T MARDEN, LJ HOLLINGER, JO AF KENLEY, RA YIM, K ABRAMS, J RON, E TUREK, T MARDEN, LJ HOLLINGER, JO TI BIOTECHNOLOGY AND BONE-GRAFT SUBSTITUTES SO PHARMACEUTICAL RESEARCH LA English DT Review DE BIOTECHNOLOGY; BONE REGENERATION; MORPHOGENETIC FACTORS; GROWTH FACTORS; DEVICES; ORTHOPEDICS ID GROWTH-FACTOR-BETA; MORPHOGENETIC PROTEIN; OSTEOGENIC PROTEIN; POROUS HYDROXYAPATITE; TRICALCIUM PHOSPHATE; MARROW-CELLS; INDUCTION; REGENERATION; PURIFICATION; CERAMICS AB Trauma, disease, developmental deformities, and tumor resection frequently cause bone defects that seriously challenge the skills of orthopedic and maxillofacial surgeons. Currently, repairing osseous deficiencies involves various medical surgical techniques, including autogenous grafts, allografts, internal and external fixation devices, electrical stimulation. and alloplastic implants. The existing technology, though effective in many cases, still is beset with numerous difficulties and disadvantages. A critical need for improved treatment methods exists today. Biotechnology now provides access to new bone repair concepts via administration of protein growth and morphogenic factors. Implantable device and drug delivery system technologies also have advanced. The converging biopharmaceutical, device, and delivery technologies represent an opportunity to improve the quality of health care for individuals with orthopedic and maxillofacial deficiencies. This report reviews current concepts in fracture healing and bone repair and examines existing treatment modalities. It also addresses novel protein drugs that stimulate osseous regeneration and delivery systems for these drugs. C1 FOCAL INTERVENT THERAPIES INC,CAMBRIDGE,MA 02139. WALTER REED ARMY MED CTR,US ARMY INST DENT RES,WASHINGTON,DC 20307. RP KENLEY, RA (reprint author), GENET INST INC,1 BURTT RD,ANDOVER,MA 01810, USA. NR 75 TC 94 Z9 95 U1 3 U2 7 PU PLENUM PUBL CORP PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 SN 0724-8741 J9 PHARMACEUT RES JI Pharm. Res. PD OCT PY 1993 VL 10 IS 10 BP 1393 EP 1401 DI 10.1023/A:1018902720816 PG 9 WC Chemistry, Multidisciplinary; Pharmacology & Pharmacy SC Chemistry; Pharmacology & Pharmacy GA MA421 UT WOS:A1993MA42100001 PM 8272399 ER PT J AU SCULLY, MO DOWLING, JP AF SCULLY, MO DOWLING, JP TI QUANTUM-NOISE LIMITS TO MATTER-WAVE INTERFEROMETRY SO PHYSICAL REVIEW A LA English DT Article ID ATOMS; INTERFERENCE; SPECTROSCOPY; NEUTRON; STATES; PHASE AB We derive the quantum limits for an atomic interferometer from a second-quantized theory in which the atoms obey either Bose-Einstein or Fermi-Dirac statistics. It is found that the limiting quantum noise is due to the uncertainty associated with the particle sorting between the two branches of the interferometer, and that this noise can be reduced in a sufficiently dense atomic beam by using fermions as opposed to bosons. As an example, the quantum-limited sensitivity of a generic matter-wave gyroscope is calculated and compared with that of a laser gyroscope. C1 MAX PLANCK INST QUANTUM OPT,W-8046 GARCHING,GERMANY. USA,MISSILE COMMAND,CTR RES DEV & ENGN,REDSTONE ARSENAL,AL 35898. RP SCULLY, MO (reprint author), TEXAS A&M UNIV SYST,DEPT PHYS,COLL STN,TX 77843, USA. RI DOWLING, JONATHAN/L-2749-2013 NR 24 TC 50 Z9 54 U1 0 U2 12 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1050-2947 J9 PHYS REV A JI Phys. Rev. A PD OCT PY 1993 VL 48 IS 4 BP 3186 EP 3190 DI 10.1103/PhysRevA.48.3186 PG 5 WC Optics; Physics, Atomic, Molecular & Chemical SC Optics; Physics GA MC717 UT WOS:A1993MC71700075 ER PT J AU MOUL, JW AF MOUL, JW TI PROSTATITIS - SORTING OUT THE DIFFERENT CAUSES SO POSTGRADUATE MEDICINE LA English DT Article AB Both acute and chronic bacterial prostatitis are generally caused by gram-negative organisms. However, acute infections are seen in younger men and cause fever, difficulty in voiding, low back and perineal pain, and other systemic symptoms. Chronic infections are more often seen in older men and may or may not be associated with symptoms of prostatitis. Nonbacterial prostatitis is the most common type. Patients have symptoms and signs of prostatitis, but infecting organisms cannot be demonstrated. Studies attempting to identify a causative organism have not been conclusive. Prostatodynia is a complex of symptoms similar to prostatitis that occurs without objective findings that definitely implicate the prostate gland. Bladder disorders such as internal sphincter dyssynergia, tension myalgia of the pelvic floor, or, at times, stress and emotional problems may be associated. Management depends on the precipitating factor. C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 6 TC 14 Z9 14 U1 0 U2 0 PU MCGRAW HILL HEALTHCARE PUBLICATIONS PI MINNEAPOLIS PA 4530 WEST 77TH ST, MINNEAPOLIS, MN 55435-5000 SN 0032-5481 J9 POSTGRAD MED JI Postgrad. Med. PD OCT PY 1993 VL 94 IS 5 BP 191 EP & PG 0 WC Medicine, General & Internal SC General & Internal Medicine GA MB770 UT WOS:A1993MB77000016 PM 8415332 ER PT J AU WEIR, JP ELKINS, KL AF WEIR, JP ELKINS, KL TI REPLICATION-INCOMPETENT HERPESVIRUS VECTOR DELIVERY OF AN INTERFERON-ALPHA GENE INHIBITS HUMAN-IMMUNODEFICIENCY-VIRUS REPLICATION IN HUMAN MONOCYTES SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article ID GLYCOPROTEIN-C GENE; SIMPLEX VIRUS; TYPE-1; INFECTION; IDENTIFICATION; LYMPHOCYTES; EXPRESSION; SEQUENCES; THERAPY; REGION AB Human monocytes and macrophages are nondividing cells that serve as a major reservoir for human immunodeficiency virus (HIV) at all stages of infection. To investigate viral-mediated gene delivery as a means of inhibiting HIV replication in human monocytes, a replication-incompetent herpes simplex virus vector was developed that expressed human interferon alpha. Monocytes infected with this herpes simplex virus vector and then challenged with HIV showed dramatically reduced cytopathic effects and HIV replication compared to control treated monocytes. Similar effects on HIV replication were observed if monocytes were first infected with HIV and then treated with the recombinant vectors. These results demonstrate that replication-incompetent herpes simplex virus gene delivery of interferon alpha directly to human monocytes can greatly decrease HIV replication and suggest that such a vector might deliver therapeutically important genes directly to sites of HIV infection. C1 WALTER REED ARMY INST RES,DEPT CELLULAR IMMUNOL,WASHINGTON,DC 20307. US FDA,CTR BIOL EVALUAT & RES,BETHESDA,MD 20892. NR 25 TC 16 Z9 16 U1 0 U2 0 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD OCT 1 PY 1993 VL 90 IS 19 BP 9140 EP 9144 DI 10.1073/pnas.90.19.9140 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA MA595 UT WOS:A1993MA59500080 PM 8415668 ER PT J AU DOLLINS, AB LYNCH, HJ WURTMAN, RJ DENG, MH KISCHKA, KU GLEASON, RE LIEBERMAN, HR AF DOLLINS, AB LYNCH, HJ WURTMAN, RJ DENG, MH KISCHKA, KU GLEASON, RE LIEBERMAN, HR TI EFFECT OF PHARMACOLOGICAL DAYTIME DOSES OF MELATONIN ON HUMAN MOOD AND PERFORMANCE SO PSYCHOPHARMACOLOGY LA English DT Article DE HUMAN; MELATONIN; MOOD; PERFORMANCE; REACTION TIME; VIGILANCE; FATIGUE; CIRCADIAN; SLEEP; ALERTNESS ID DOUBLE-BLIND TRIAL; JET-LAG; ACTIVITY RHYTHM; SLEEP; TRIAZOLAM; HAMSTERS; FATIGUE; LIGHT; TIME AB Melatonin (10, 20, 40, or 80 mg, PO) or placebo was administered at 1145 hours on five separate occasions to 20 healthy male volunteers and the effects on serum melatonin levels, mood, performance, and oral temperature were monitored. Subjects were studied between 0930 and 1700 hours. A battery of interactive computer tasks designed to assess performance and mood was completed, oral temperature was measured, and blood samples were taken for serum melatonin radioimmunoassay. The areas under the time-melatonin concentration curve (AUC) varied significantly in proportion to the various melatonin doses. Compared with placebo treatment, all melatonin doses significantly decreased oral temperature, number of correct responses in auditory vigilance, response latency in reaction time, and self-reported vigor. Melatonin also increased self-reported fatigue, confusion, and sleepiness. C1 MIT,DEPT BRAIN & COGNIT SCI,CAMBRIDGE,MA 02139. MIT,CLIN RES CTR,CAMBRIDGE,MA 02139. DOD POLYGRAPH INST,FT MCCLELLAN,AL 36205. USA,ENVIRONM MED RES INST,DIV MIL PERFORMANCE & NEUROSCI,NATICK,MA 01760. FU NCRR NIH HHS [M01-RR-00088] NR 47 TC 99 Z9 99 U1 0 U2 3 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0033-3158 J9 PSYCHOPHARMACOLOGY JI Psychopharmacology PD OCT PY 1993 VL 112 IS 4 BP 490 EP 496 DI 10.1007/BF02244899 PG 7 WC Neurosciences; Pharmacology & Pharmacy; Psychiatry SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry GA ME588 UT WOS:A1993ME58800014 PM 7871062 ER PT J AU MILLER, MS KOTLAR, AJ AF MILLER, MS KOTLAR, AJ TI TECHNIQUE FOR MEASURING THERMAL-DIFFUSIVITY CONDUCTIVITY OF SMALL THERMAL-INSULATOR SPECIMENS SO REVIEW OF SCIENTIFIC INSTRUMENTS LA English DT Article AB An experimental technique to measure simultaneously the thermal diffusivity and thermal conductivity of small specimens of thermal-insulator materials is described. Experimental conditions are developed which approach the mathematical idealization of a one-dimensional, infinite, two-component, composite solid whose planar interface is subjected to a step-function heat flux. The heat flux is generated by resistive heating of a thin metallic foil. Although this principle has been exploited previously, the present technique permits specimens with volumes two orders of magnitude smaller than prior work based on the same idealization. A number of difficulties related to small specimen volume are identified and overcome. Another improvement over past efforts is the use of the nonlinear least-squares analysis to determine the optimum values for diffusivity and conductivity. A comparison of measurements of these properties for acrylic and Pyrex glass with literature values suggests that the technique affords accuracies of about 5% for materials in this range. RP MILLER, MS (reprint author), USA,RES LAB,ABERDEEN PROVING GROUND,MD 21005, USA. NR 23 TC 9 Z9 10 U1 0 U2 1 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0034-6748 J9 REV SCI INSTRUM JI Rev. Sci. Instrum. PD OCT PY 1993 VL 64 IS 10 BP 2954 EP 2960 DI 10.1063/1.1144340 PG 7 WC Instruments & Instrumentation; Physics, Applied SC Instruments & Instrumentation; Physics GA MC137 UT WOS:A1993MC13700038 ER PT J AU CHEU, HW GRISHKIN, BA LINVILLE, WK AF CHEU, HW GRISHKIN, BA LINVILLE, WK TI ENDOBRONCHIAL HAMARTOMA TREATED BY BRONCHOSCOPIC EXCISION SO SOUTHERN MEDICAL JOURNAL LA English DT Note C1 BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234. RP CHEU, HW (reprint author), WILFORD HALL USAF MED CTR,SURG SERV,DEPT GEN SURG,LACKLAND AFB,TX 78236, USA. NR 6 TC 2 Z9 3 U1 0 U2 0 PU SOUTHERN MEDICAL ASSN PI BIRMINGHAM PA 35 LAKESHORE DR PO BOX 190088, BIRMINGHAM, AL 35219 SN 0038-4348 J9 SOUTHERN MED J JI South.Med.J. PD OCT PY 1993 VL 86 IS 10 BP 1164 EP 1165 DI 10.1097/00007611-199310000-00018 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA MD260 UT WOS:A1993MD26000018 PM 8211338 ER PT J AU CIESLAK, TJ OTTOLINI, MG ONEILL, KM LAMPE, RM AF CIESLAK, TJ OTTOLINI, MG ONEILL, KM LAMPE, RM TI STAPHYLOCOCCUS-AUREUS MENINGITIS ASSOCIATED WITH PYOGENIC INFECTION OF THE SACROILIAC JOINT SO SOUTHERN MEDICAL JOURNAL LA English DT Note ID ARTHRITIS C1 WALTER REED ARMY MED CTR,DEPT PEDIAT,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,DEPT PEDIAT,BETHESDA,MD 20814. NR 19 TC 7 Z9 7 U1 0 U2 0 PU SOUTHERN MEDICAL ASSN PI BIRMINGHAM PA 35 LAKESHORE DR PO BOX 190088, BIRMINGHAM, AL 35219 SN 0038-4348 J9 SOUTHERN MED J JI South.Med.J. PD OCT PY 1993 VL 86 IS 10 BP 1175 EP 1178 DI 10.1097/00007611-199310000-00023 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA MD260 UT WOS:A1993MD26000023 PM 8211343 ER PT J AU JOHNSON, SH KRAIMER, JM GRAEBER, GM AF JOHNSON, SH KRAIMER, JM GRAEBER, GM TI EFFECTS OF FLUNARIZINE ON NEUROLOGICAL RECOVERY AND SPINAL-CORD BLOOD-FLOW IN EXPERIMENTAL SPINAL-CORD ISCHEMIA IN RABBITS SO STROKE LA English DT Article DE CALCIUM CHANNEL BLOCKERS; NEUROPROTECTION; SPINAL CORD; RABBITS ID CALCIUM-CHANNEL BLOCKER; ANTAGONIST NIMODIPINE; INCOMPLETE ISCHEMIA; RAT-BRAIN; INJURY; DAMAGE; CIRCULATION; PROTECTION; NEURONS AB Background and Purpose: The lipophilic calcium channel antagonist flunarizine has been demonstrated to be neuroprotective in several models of cerebral ischemia. Ischemic spinal cord injury may have a similar pathophysiology and hence may respond in a similar fashion. This study was designed to investigate the effects of pretreatment with flunarizine on systemic hemodynamics, spinal cord blood flow, and neurological recovery in a rabbit model of ischemic spinal cord injury. Methods: New Zealand White rabbits were anesthetized with ketamine and xylazine and instrumented for systemic blood pressure monitoring and spinal cord blood flow measurements using the microsphere method. After pretreatment with flunarizine or vehicle, ischemic spinal cord injury was created selectively in the caudal regions of the spinal cord by cross-clamping the abdominal aorta for a period of 25 minutes. Spinal cord blood flow was measured before, during, and 15 minutes after cross-clamp removal. Animals were allowed to recover and were graded neurologically at 18 and 24 hours after ischemia. Results: Flunarizine injection was associated with hypotension that was both transient and dose related. Animals pretreated with flunarizine 0.4 mg/kg had significantly improved neurological recovery scores at 18 hours after ischemia (P=.017) compared with vehicle controls. At 24 hours this effect was lessened (P=.095); however, 60% of flunarizine-treated animals retained their ability to hop, whereas all of the vehicle-treated animals were nonambulatory. Conclusions: Flunarizine has a protective effect on neurological recovery after experimental ischemic spinal cord injury. The therapeutic window is narrow, and dosing is limited by untoward hypotension. The mechanism of protection likely involves inhibition of pathological cytosolic calcium accumulation rather than a direct effect on vascular smooth muscle. C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DIV SURG,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,F EDWARD HEBERT SCH MED,DEPT SURG,BETHESDA,MD 20814. W VIRGINIA UNIV,MED CTR,SCH MED,THORAC & CARDIOVASC SURG SECT,MORGANTOWN,WV 26506. W VIRGINIA UNIV,MED CTR,SCH MED,SURG RES SECT,MORGANTOWN,WV 26506. UNIV VERMONT,SCH MED,DEPT NEUROSURG,BURLINGTON,VT 05405. NR 38 TC 74 Z9 86 U1 0 U2 2 PU AMER HEART ASSOC PI DALLAS PA 7272 GREENVILLE AVENUE, DALLAS, TX 75231-4596 SN 0039-2499 J9 STROKE JI Stroke PD OCT PY 1993 VL 24 IS 10 BP 1547 EP 1553 PG 7 WC Clinical Neurology; Peripheral Vascular Disease SC Neurosciences & Neurology; Cardiovascular System & Cardiology GA LZ540 UT WOS:A1993LZ54000022 PM 8378960 ER PT J AU REUSS, M AF REUSS, M TI THE HISTORY OF HYDRAULIC ENGINEERING IN SWITZERLAND - GERMAN - SCHNITTER,N SO TECHNOLOGY AND CULTURE LA English DT Book Review RP REUSS, M (reprint author), USA,CORPS ENGINEERS,WASHINGTON,DC 20310, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0040-165X J9 TECHNOL CULT JI Technol. Cult. PD OCT PY 1993 VL 34 IS 4 BP 936 EP 938 DI 10.2307/3106429 PG 3 WC History & Philosophy Of Science SC History & Philosophy of Science GA MV523 UT WOS:A1993MV52300019 ER PT J AU GOWDA, TV MIDDLEBROOK, JL AF GOWDA, TV MIDDLEBROOK, JL TI EFFECTS OF MYONECROTIC SNAKE-VENOM PHOSPHOLIPASE-A(2) TOXINS ON CULTURED MUSCLE-CELLS SO TOXICON LA English DT Article ID NAJA-NIGRICOLLIS VENOM; VIPERA-RUSSELLI VENOM; EDEMA-INDUCING PHOSPHOLIPASE-A2; N-TERMINAL REGION; BASIC PHOSPHOLIPASE-A2; PHARMACOLOGICAL PROPERTIES; TOXICOLOGICAL PROPERTIES; ENZYMATIC-ACTIVITY; PURIFICATION; DISSOCIATION AB We have attempted to establish a cell culture model suitable for molecular mechanism of action studies of necrotic phospholipases A2 (PLA2). Three myonecrotic PLA2 were purified, one basic PLA2 from Naja nigricollis venom and two basic PLA2 (VRV-PL-V and VRV-PL-VIIIa) from Vipera russelli venom. The effects of these PLA2 on several established muscle cell lines were evaluated. As judged by light microscopy, some, but not all, cell lines detached from the culture plate in a time- and concentration-related fashion. Naja nigricollis PLA2 was the most potent at eliciting this effect, followed by VRV-PL-V and VRV-PL-VIIIa. The two most sensitive cell lines, 1447 and 1456, were chosen for further study using N. nigricollis PLA2. Cellular protein and nucleic acid syntheses were inhibited by the toxin in a time- and dose-related manner. However, it appeared that most, if not all, of the inhibition was due to toxin-induced reduction of precursor uptake, suggesting effects at the plasma membrane level. The putative membrane effects were specific, in that uptake of calcium, choline or glucose was not inhibited by the toxin. Moreover, treating the cells with toxin failed to significantly increase lactate dehydrogenase release into the medium. Polyclonal antiserum prepared against N. nigricollis basic PLA2 neutralized the toxicity completely with 1456 cells, but only partially with the 1447 cell line. Both the 1447 and 1456 lines appear to be suitable as cell culture models for necrotizing PLA2 molecular mechanism of action studies. C1 USA,INFECT DIS RES INST,DIV TOXICOL,FREDERICK,MD 21702. NR 47 TC 12 Z9 12 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0041-0101 J9 TOXICON JI Toxicon PD OCT PY 1993 VL 31 IS 10 BP 1267 EP 1278 DI 10.1016/0041-0101(93)90400-D PG 12 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA MH840 UT WOS:A1993MH84000007 PM 8303721 ER PT J AU MOUL, JW WIND, GG WRIGHT, CR AF MOUL, JW WIND, GG WRIGHT, CR TI TORTUOUS AND ABERRANT EXTERNAL ILIAC ARTERY PRECLUDING RADICAL RETROPUBIC PROSTATECTOMY FOR PROSTATE-CANCER SO UROLOGY LA English DT Article ID SURGERY AB A sixty-eight-year-old black man with clinical Stage A1 (T1a) adenocarcinoma of the prostate was found to have a tortuous and redundant left external iliac artery directly overlying the superior aspect of the prostate gland. The location of this blood vessel precluded radical retropubic prostatectomy. To our knowledge, this is the first reported example of this clinical situation. Computer-generated three-dimensional imaging from the computed tomography scan allowed accurate assessment of the vascular anomaly. C1 WALTER REED ARMY MED CTR,DEPT SURG,UROL SERV,WASHINGTON,DC 20307. RP MOUL, JW (reprint author), UNIFORMED SERV UNIV HLTH SCI,DEPT SURG,4301 JONES BRIDGE RD,BETHESDA,MD 20814, USA. NR 11 TC 1 Z9 1 U1 0 U2 0 PU CAHNERS PUBL CO PI NEW YORK PA 249 WEST 17 STREET, NEW YORK, NY 10011 SN 0090-4295 J9 UROLOGY JI UROLOGY PD OCT PY 1993 VL 42 IS 4 BP 450 EP 452 DI 10.1016/0090-4295(93)90384-M PG 3 WC Urology & Nephrology SC Urology & Nephrology GA MC625 UT WOS:A1993MC62500029 PM 8212448 ER PT J AU WHITE, K KRZYCH, U GORDON, DM PORTER, TG RICHARDS, RL ALVING, CR DEAL, CD HOLLINGDALE, M SILVERMAN, C SYLVESTER, DR BALLOU, WR GROSS, M AF WHITE, K KRZYCH, U GORDON, DM PORTER, TG RICHARDS, RL ALVING, CR DEAL, CD HOLLINGDALE, M SILVERMAN, C SYLVESTER, DR BALLOU, WR GROSS, M TI INDUCTION OF CYTOLYTIC AND ANTIBODY-RESPONSES USING PLASMODIUM-FALCIPARUM REPEATLESS CIRCUMSPOROZOITE PROTEIN ENCAPSULATED IN LIPOSOMES SO VACCINE LA English DT Article DE MALARIA; REPEATLESS CIRCUMSPOROZOITE PROTEIN; CYTOLYTIC-T CELLS; ANTIBODY; LIPOSOMES ID TOXIC T-CELLS; CYTOTOXIC LYMPHOCYTES-T; SPOROZOITE VACCINE; SYNTHETIC PEPTIDE; MALARIA VACCINE; ANTIGEN; IMMUNOGENICITY; SAFETY; PHAGOCYTOSIS; STIMULATION AB Plasmodium circumsporozoite (CS) protein-induced antibody and T-cell responses are considered to be important in protective immunity. Since the key repeat determinant of the CS protein may actually restrict the recognition of other potential T- and B-cell sites, a modified Plasmodium falciparum CS protein lacking the central repeat region, RLF, was expressed in Escherichia coli. On purification, RLF was encapsulated into liposomes [L(RLF)] and used for the in vivo induction of cytolytic T lymphocytes (CTL) and antibodies. Immunization of B10.Br (H-2k) mice with L(RLF), but not with RLF, induced CD8+ CTL specific for the P. falciparum CS protein CTL epitope, amino acid residues 368-390. Anti-L(RLF) serum reacted with antigens on intact sporozoites and inhibited sporozoite invasion of hepatoma cells. Antibody specificity studies in New Zealand White rabbits revealed new B-cell sites localized in amino acid residues 84-94, 91-99, 97-106 and 367-375. Although the mechanisms by which liposomes enhance cellular and humoral immune responses remain unknown, liposome-formulated vaccines have been well tolerated in humans; hence, their use in vaccines, when efficacy depends on antibody and CTL responses, may be broadly applicable. C1 WRAMC,WRAIR,DEPT IMMUNOL,WASHINGTON,DC 20307. WALTER REED ARMY INST RES,DEPT MEMBRANE BIOCHEM,WASHINGTON,DC 20307. SMITHKLINE BEECHAM PHARMACEUT,DEPT MACROMOLEC SCI,KING OF PRUSSIA,PA 19406. BIOMED RES INST,ROCKVILLE,MD 20852. SMITHKLINE BEECHAM PHARMACEUT,DEPT PROT BIOCHEM,KING OF PRUSSIA,PA 19406. WALTER REED ARMY INST RES,DEPT BACTERIAL DIS,WASHINGTON,DC 20307. NR 36 TC 31 Z9 32 U1 1 U2 1 PU BUTTERWORTH-HEINEMANN LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB SN 0264-410X J9 VACCINE JI Vaccine PD OCT PY 1993 VL 11 IS 13 BP 1341 EP 1346 DI 10.1016/0264-410X(93)90105-7 PG 6 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA MC984 UT WOS:A1993MC98400012 PM 7507624 ER PT J AU LEWIS, MG ELKINS, WR MCCUTCHAN, FE BENVENISTE, RE LAI, CY MONTEFIORI, DC BURKE, DS EDDY, GA SHAFFERMAN, A AF LEWIS, MG ELKINS, WR MCCUTCHAN, FE BENVENISTE, RE LAI, CY MONTEFIORI, DC BURKE, DS EDDY, GA SHAFFERMAN, A TI PASSIVELY TRANSFERRED ANTIBODIES DIRECTED AGAINST CONSERVED REGIONS OF SIV ENVELOPE PROTECT MACAQUES FROM SIV INFECTION SO VACCINE LA English DT Article DE ENVELOPE PEPTIDE VACCINE; NEUTRALIZING ANTIBODIES; HUMAN IMMUNODEFICIENCY VIRUS ID IMMUNODEFICIENCY-VIRUS TYPE-1; MONOCLONAL-ANTIBODIES; RECOMBINANT GP160; HIV-INFECTION; VACCINE; IDENTIFICATION; GLYCOPROTEIN; IMMUNIZATION; PREVENTION; SEQUENCES AB Inactivated plasma collected from either SIV-infected or peptide-vaccinated macaques was transferred into 17 naive rhesus monkeys. Two additional macaques received normal plasma and served as controls. Following transfer all 19 monkeys were inoculated with SIV. While the controls became infected and were virus-isolation-positive, 3 of 6 recipients of SIV peptide vaccine plasma and 9 of 11 recipients of SIV-infected monkey plasma were protected. None of the 12 protected animals became virus-isolation-positive or seroconverted within 100 days of follow-up. One, however was SIV-PCR-positive. All 12 protected animals were rechallenged 100 days after the initial inoculation; 8 became infected and yielded virus as expected, but 4 remained uninfected. One of the latter was the SIV-PCR-positive monkey mentioned above, suggesting that cryptic SIV infection may be of significance in immunological protection. The results demonstrate that envelope anti-peptide antibodies have similar protective potential in vivo as antibodies directed to the whole virus. In vitro neutralization competition assays performed with sera from vaccinated macaques in the presence of the free peptides suggest that of the four conserved envelope peptides of the vaccine, the two originating from gp41 rather than the two from gp120 are responsible for inducing the neutralizing anti-syncytial activity. C1 NCI,VIRAL CARCINOGENESIS LAB,FREDERICK,MD 21702. WALTER REED ARMY INST RES,DIV RETROVIROL,ROCKVILLE,MD 20852. ISRAEL INST BIOL RES,DEPT BIOCHEM,IL-70450 NESS ZIONA,ISRAEL. NIAID,INFECT DIS LAB,ROCKVILLE,MD 20852. VANDERBILT UNIV,MED CTR,SCH MED,DEPT PATHOL,NASHVILLE,TN 37232. RP LEWIS, MG (reprint author), HENRY M JACKSON FDN RES LAB,1500E GUDE DR,ROCKVILLE,MD 20852, USA. OI /0000-0002-5704-8094 NR 38 TC 63 Z9 64 U1 0 U2 1 PU BUTTERWORTH-HEINEMANN LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB SN 0264-410X J9 VACCINE JI Vaccine PD OCT PY 1993 VL 11 IS 13 BP 1347 EP 1355 DI 10.1016/0264-410X(93)90106-8 PG 9 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA MC984 UT WOS:A1993MC98400013 PM 7507625 ER PT J AU HASE, T AF HASE, T TI MORPHOGENESIS OF THE PROTEIN SECRETORY SYSTEM IN PC12 CELLS INFECTED WITH JAPANESE ENCEPHALITIS-VIRUS SO VIRCHOWS ARCHIV B-CELL PATHOLOGY INCLUDING MOLECULAR PATHOLOGY LA English DT Article DE GOLGI APPARATUS; JAPANESE ENCEPHALITIS VIRUS; MORPHOGENESIS OF PROTEIN SECRETORY SYSTEM; PC12 CELL; ROUGH ENDOPLASMIC RETICULUM ID SIGNAL RECOGNITION PARTICLE; MICROTUBULE-ORGANIZING CENTER; ENDOPLASMIC-RETICULUM; GOLGI-APPARATUS; MICROSOMAL-MEMBRANES; TRANSLOCATION; INVITRO; TRANSLATION; RECEPTOR; POLARIZATION AB Infection of PC12 cells with Japanese encephalitis (JE) virus caused marked proliferation of the protein secretory system. Accordingly, in this study the morphogenesis of the secretory orgenelles, i.e., rough endoplasmic reticulum (RER) and the Golgi apparatus, in JE virus-infected PC12 cells was analyzed by electron microscopical observation. Starting 24 h postinoculation (p.i.), a structure that represented nascent RER appeared in the cytoplasm in the form of rows of ribosomes which surrounded membrane-unbounded, electron-lucent lacunae in a reticular, honey-comb pattern (reticular RER). Although the reticular RER lacked membrane components, its lacunae contained progeny virions, indicating that the rows of ribosomes synthesized the viral proteins and discharged them into the lacunae for the viral assembly. The reticular RER apparently transformed into the familiar lamellar RER during the RER morphogenesis as the lacunae coalesced to form flat cisternae and RER membrane assembled to border the cisternae. These findings indicated that the proliferating RER was the site of not only active protein synthesis but also active membrane biogenesis. The proliferating RER released a large number of membrane vesicles including virion-carrying vesicles into the cytoplasm. These vesicles congregated in the juxtanuclear region, especially around the centrioles, and fused to existing Golgi complexes for enlargement or fused among themselves to form new Golgi complexes. The present study, therefore, indicated that (a) nascent RER was formed by polysomes that arranged themselves in rows of ribosomes without participation of a preexisting membrane framework of endoplasmic reticulum (ER), (b) membrane components of RER were assembled de novo within the structure during the RER morphogenesis, and (c) RER released membrane vesicles that moved to the Golgi apparatus and contributed to the morphogenesis of the Golgi apparatus- Possible causative mechanisms involved in the proliferation of the secretory system in JE virus-infected PC12 cells are discussed. RP HASE, T (reprint author), WALTER REED ARMY INST RES,DEPT ULTRASTRUCT PATHOL,WASHINGTON,DC 20307, USA. NR 22 TC 2 Z9 2 U1 0 U2 0 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0340-6075 J9 VIRCHOWS ARCH B JI Virchows Arch. B-Cell Molec. Pathol. PD OCT PY 1993 VL 64 IS 4 BP 229 EP 239 DI 10.1007/BF02915117 PG 11 WC Pathology SC Pathology GA MD856 UT WOS:A1993MD85600005 PM 8287119 ER PT J AU SOMMERS, RJ AF SOMMERS, RJ TI FALLEN LEAVES - THE CIVIL-WAR LETTERS OF ABBOTT,HENRY,LIVERMORE - SCOTT,RG SO VIRGINIA MAGAZINE OF HISTORY AND BIOGRAPHY LA English DT Book Review RP SOMMERS, RJ (reprint author), USA,INST MIL HIST,WASHINGTON,DC 20310, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU VIRGINIA HISTORICAL SOC PI RICHMOND PA BOX 7311, RICHMOND, VA 23221 SN 0042-6636 J9 VA MAG HIST BIOG JI VA. Mag. Hist. Biogr. PD OCT PY 1993 VL 101 IS 4 BP 558 EP 559 PG 2 WC History SC History GA MT899 UT WOS:A1993MT89900012 ER PT J AU SETHNA, M WEIR, JP AF SETHNA, M WEIR, JP TI MUTATIONAL ANALYSIS OF THE HERPES-SIMPLEX VIRUS TYPE-1 GLYCOPROTEIN-E PROMOTER SO VIROLOGY LA English DT Article ID CELLULAR TRANSCRIPTION FACTOR; THYMIDINE KINASE GENE; SHORT UNIQUE REGION; TATA BOX; MESSENGER-RNA; GAMMA-2 GENES; C GENE; EXPRESSION; SEQUENCES; ACTIVATION C1 HENRY M JACKSON FDN ADVANCEMENT MIL MED,WALTER REED ARMY INST RES,DEPT CELLULAR IMMUNOL,ROCKVILLE,MD 20850. UNIV TENNESSEE,DEPT MICROBIOL,KNOXVILLE,TN 37996. FU NIAID NIH HHS [AI24471] NR 29 TC 14 Z9 14 U1 0 U2 0 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0042-6822 J9 VIROLOGY JI Virology PD OCT PY 1993 VL 196 IS 2 BP 532 EP 540 DI 10.1006/viro.1993.1508 PG 9 WC Virology SC Virology GA LY071 UT WOS:A1993LY07100015 PM 8396801 ER PT J AU XIAO, SY SPIK, KW LI, DX SCHMALJOHN, CS AF XIAO, SY SPIK, KW LI, DX SCHMALJOHN, CS TI NUCLEOTIDE AND DEDUCED AMINO-ACID-SEQUENCES OF THE M-GENOME AND S-GENOME SEGMENTS OF 2 PUUMALA VIRUS ISOLATES FROM RUSSIA SO VIRUS RESEARCH LA English DT Article DE PUUMALA VIRUS; NUCLEOTIDE SEQUENCE; AMINO ACID SEQUENCE ID NEPHROPATHIA-EPIDEMICA; HEMORRHAGIC-FEVER; RENAL SYNDROME; HANTAVIRUSES; CLONING AB Hemorrhagic fever with renal syndrome (HFRS) is caused by viruses in the Hantavirus genus, family Bunyaviridae. Three serologically distinct hantaviruses, Hantaan, Seoul and Puumala viruses, are known to cause HFRS. We report here, for the first time, gene sequences of two human Puumala virus isolates, P360 and K27, obtained in an HFRS endemic region of the former Soviet Union. We compared the nucleotide sequences and the derived amino acid sequences of their gene products to a Puumala virus isolate from rodents. C1 USA,MED RES INST INFECT DIS,DIV VIROL,FT DETRICK,FREDERICK,MD 21702. RI Xiao, Shu-Yuan/E-2215-2012 NR 10 TC 41 Z9 48 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0168-1702 J9 VIRUS RES JI Virus Res. PD OCT PY 1993 VL 30 IS 1 BP 97 EP 103 PG 7 WC Virology SC Virology GA MA620 UT WOS:A1993MA62000009 PM 8266723 ER PT J AU WANG, XH NI, ZJ LU, XJ HOLLIS, A BANKS, H RODRIGUEZ, A PADWA, A AF WANG, XH NI, ZJ LU, XJ HOLLIS, A BANKS, H RODRIGUEZ, A PADWA, A TI [2,3]-SIGMATROPIC REARRANGEMENT OF BETA-PHENYLSULFONYL PROPARGYLIC SULFENATES AS A METHOD FOR PREPARING 1,4-BIS(PHENYLSULFONYL)-1,3-BUTADIENES SO JOURNAL OF ORGANIC CHEMISTRY LA English DT Article ID DIELS-ALDER REACTIONS; 2,3 SIGMATROPIC REARRANGEMENTS; CYCLO-ADDITIONS; NEOCARZINOSTATIN CHROMOPHORE; 2-PHENYLSULFONYL 1,3-DIENES; OXIDATIVE DESULFONYLATION; CYCLOADDITION CHEMISTRY; ORGANIC TRANSFORMATIONS; CHEMICAL CHAMELEONS; VERSATILE SYNTHONS AB Several beta-sulfoxy-substituted acetylenic carbinols were prepared by the addition of thiyl radicals and oxygen to conjugated enynes. The products obtained are derived from thiyl radical attack at the olefinic bond to generate a propargylic radical. Capture of this radical by oxygen followed by hydrogen transfer from thiophenol gives a hydroperoxide intermediate, which undergoes oxygen transfer by both intra- and intermolecular pathways. The resultant beta-phenylsulfinyl propargylic alcohols proved to be versatile intermediates for the preparation of several different classes of compounds. The [2,3]-sigmatropic sulfinate to sulfoxide rearrangement was found to give 1,4-bis(phenylsulfonyl)-1,3-butadienes, alpha,beta-unsaturated phenylsulfoxy ketones, and beta-phenylsulfonyl alpha-allenic sulfoxides' Oxidation of the sulfoxy moiety to the sulfone followed by sulfinate formation with phenylsulfenyl chloride produces, after [2,3]-sigmatropic rearrangement, beta-phenylsulfonyl alpha-allenic sulfoxides. In certain cases these allenes could be isolated, but were usually isomerized in situ and further oxidized to give 1,4-bis(phenylsulfonyl)-1,3-butadienes. The [2,3]-sigmatropic rearrangement of beta-phenyl-sulfinyl-substituted propargylic alcohols proceeds by an entirely different course. With these systems, a double sigmatropic process occurs leading to the formation of vinyl sulfinates which are readily hydrolyzed to give alpha,beta-unsaturated phenylsulfoxy ketones. C1 EMORY UNIV,DEPT CHEM,ATLANTA,GA 30322. USA,CTR CHEM RES DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010. RP WANG, XH (reprint author), CLARK ATLANTA UNIV,DEPT CHEM,ATLANTA,GA 30314, USA. NR 106 TC 18 Z9 18 U1 1 U2 4 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0022-3263 J9 J ORG CHEM JI J. Org. Chem. PD SEP 24 PY 1993 VL 58 IS 20 BP 5377 EP 5385 DI 10.1021/jo00072a019 PG 9 WC Chemistry, Organic SC Chemistry GA LZ660 UT WOS:A1993LZ66000019 ER PT J AU YU, N ROMEROBORJA, F ZHANG, ZH CUI, XT LIU, JR WOOD, LT CHU, WK MARTON, D RABALAIS, JW FORSTER, KM REEBER, RR AF YU, N ROMEROBORJA, F ZHANG, ZH CUI, XT LIU, JR WOOD, LT CHU, WK MARTON, D RABALAIS, JW FORSTER, KM REEBER, RR TI FORMATION OF BORON-NITRIDE AND BORON-CARBIDE COMPOSITE BY NITROGEN IMPLANTATION AT ELEVATED-TEMPERATURE SO APPLIED PHYSICS LETTERS LA English DT Article ID ION-IMPLANTATION; FRICTION; CERAMICS; WEAR; B4C AB Boron carbide (B4C) is a wear resistant material with hardness slightly less than that of diamond. It has an excellent strength to weight ratio and relatively high toughness under controlled processing. These essential mechanical properties make B4C an ideal candidate for cutting tool and bearing applications. We will demonstrate that hexagonal boron nitride (h-BN), a good solid lubricant, can be formed on B4C surfaces through high temperature (850-degrees-C) nitrogen ion implantation. The formation of composite B4C and h-BN on the B4C surface can potentially reduce surface friction coefficients, making the material more attractive for tribological applications. C1 UNIV HOUSTON,TEXAS CTR SUPERCONDUCT,HOUSTON,TX 77204. UNIV HOUSTON,DEPT CHEM,HOUSTON,TX 77204. UNIV HOUSTON,DEPT CHEM ENGN,HOUSTON,TX 77204. USA,RES OFF,RES TRIANGLE PK,NC 27209. RP YU, N (reprint author), UNIV HOUSTON,DEPT PHYS,HOUSTON,TX 77204, USA. RI Marton, Denes/E-7759-2010 NR 18 TC 6 Z9 6 U1 1 U2 10 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD SEP 20 PY 1993 VL 63 IS 12 BP 1643 EP 1645 DI 10.1063/1.110722 PG 3 WC Physics, Applied SC Physics GA LX607 UT WOS:A1993LX60700017 ER PT J AU HEPPNER, DG MAGILL, AJ GASSER, RA AF HEPPNER, DG MAGILL, AJ GASSER, RA TI INFECTIOUS-DISEASES IN SOMALIA - REPLY SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Letter ID FALCIPARUM-MALARIA C1 KEESLER MED CTR,KEESLER AFB,MS 39534. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. RP HEPPNER, DG (reprint author), WALTER REED ARMY INST RES,WASHINGTON,DC 20307, USA. NR 5 TC 0 Z9 0 U1 0 U2 0 PU MASS MEDICAL SOC PI BOSTON PA 10 SHATTUCK, BOSTON, MA 02115 SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD SEP 16 PY 1993 VL 329 IS 12 BP 889 EP 890 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA LW551 UT WOS:A1993LW55100033 ER PT J AU GHOSH, R MUKHERJEE, K ROYCHOWDHURY, P KLAYMAN, DL AF GHOSH, R MUKHERJEE, K ROYCHOWDHURY, P KLAYMAN, DL TI STRUCTURE OF AN ANTIMALARIAL ALKALOID, JATRORRHIZINE SO ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS LA English DT Article AB Jatrorrhizine is a naturally occurring antimalarial alkaloid. The structure of jatrorrhizine, determined from its chloride (5,6-dihydro-3-hydroxy-2,9,10-trimethoxydibenzo[a,g]quinolizinium chloride dihydrate), consists of four fused rings. The conformation of ring I (benzo) is a boat and ring II (dihydropyrido moiety) is deviated from its twist-boat conformation. The planar rings III (pyrido moiety) and IV (benzo) are very similar to the quinoline part of several quinine derivatives. Hydrogen-bonded water molecules stabilize the crystal. C1 WALTER REED ARMY INST RES,DEPT MED CHEM,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307. RP GHOSH, R (reprint author), UNIV CALCUTTA,COLL SCI,DEPT PHYS,92 APC RD,CALCUTTA 700009,W BENGAL,INDIA. NR 5 TC 7 Z9 8 U1 0 U2 4 PU MUNKSGAARD INT PUBL LTD PI COPENHAGEN PA 35 NORRE SOGADE, PO BOX 2148, DK-1016 COPENHAGEN, DENMARK SN 0108-2701 J9 ACTA CRYSTALLOGR C JI Acta Crystallogr. Sect. C-Cryst. Struct. Commun. PD SEP 15 PY 1993 VL 49 BP 1665 EP 1667 DI 10.1107/S0108270193002458 PN 9 PG 3 WC Chemistry, Multidisciplinary; Crystallography SC Chemistry; Crystallography GA MB110 UT WOS:A1993MB11000046 ER PT J AU GUTHRIE, JA BOWEN, TS ANDERSON, WR KOTLAR, AJ BUNTE, SW AF GUTHRIE, JA BOWEN, TS ANDERSON, WR KOTLAR, AJ BUNTE, SW TI UNIQUE ONE-PHOTON AND 2-PHOTON ABSORPTION PROCESSES NEAR 6000 ANGSTROM IN NASCENT CN IN A FLAME - DIRECT AND COLLISION-ASSISTED POPULATION OF THE B 2-SIGMA+ ELECTRONIC-STATE SO CHEMICAL PHYSICS LA English DT Article ID LASER-INDUCED FLUORESCENCE; ENERGY-TRANSFER; EXCITED FLUORESCENCE; DIATOMIC-MOLECULES; TRANSITION; PHOTOLYSIS; SYSTEM; BANDS; RED AB Tunable dye laser excitation of CN near 6000 angstrom in an atmospheric pressure CH4/N2O flame has resulted in the production of B 2SIGMA+-X 2SIGMA+ system fluorescence, detected in the DELTAupsilon = 0 region (almost-equal-to 3860 angstrom). Analysis shows that four different mechanisms contribute to the spectrum in overlapping laser wavelength regions: (1) In the range from 5890-6016 angstrom, the spectrum is dominated by transitions in the B 2SIGMA+-A 2PI (0,0) band. This technique can be used with care as a quantitative CN A 2PI diagnostic in flames. (2) In the range 6016-6180 angstrom the excitation spectrum is positively identified as that of the A 2PI-X 2SIGMA+ (8, 3) and (9, 4) bands. However, fluorescence occurs from the B 2SIGMA+ state which can be populated only by collisional uptransfer. Part of the A 2PI-X 2SIGMA+ (10, 5) band near 6300 angstrom has also been observed via the same mechanism; however, because A 2PI, upsilon = 10 is nearly iso-energetic with B 2SIGMA+, upsilon = 0 endoergic collisions are not necessary to promote the intersystem crossing. (3) In the range 6180-6298 angstrom, the spectrum consists mainly of lines produced by a collision-assisted single-color optical-optical double resonance (OODR). The first photon of the OODR is absorbed in the A 2PI-X 2SIGMA+ (4, 0) band, the second in the B 2SIGMA+-A 2PI (3, 4) band. The density of lines in the region is possible only if collisional rotational relaxation occurs in the intermediate A 2PI, upsilon = 4 level during the laser pulse. (4) In the same wavelength region (6180-6298 angstrom) a second, independent process occurs: near-resonant two-photon excitation (NR2PE) in the B 2SIGMA+-X 2SIGMA+ (3, 0) band by means of intermediate A 2PI, upsilon = 4 rotational levels. The only B 2SIGMA+-X 2SIGMA+ (3, 0) NR2PE transitions observed are those for which the laser is detuned from a resonance in A 2PI-X 2SIGMA+ (4, 0) by less than 20 cm-1. This two-photon absorption process is independent of collisional conditions. The observed spectra illustrate some of the unexpected effects of collisions and laser intensity on absorption and fluorescence in this molecule, characterized by multiple low-lying electronic states. C1 USA,RES LAB,ABERDEEN PROVING GROUND,MD 21005. NR 32 TC 2 Z9 2 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0301-0104 J9 CHEM PHYS JI Chem. Phys. PD SEP 15 PY 1993 VL 175 IS 2-3 BP 343 EP 356 DI 10.1016/0301-0104(93)85163-3 PG 14 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA LX363 UT WOS:A1993LX36300012 ER PT J AU VANKEKEN, PE YUEN, DA VANDENBERG, AP AF VANKEKEN, PE YUEN, DA VANDENBERG, AP TI THE EFFECTS OF SHALLOW RHEOLOGICAL BOUNDARIES IN THE UPPER-MANTLE ON INDUCING SHORTER TIME SCALES OF DIAPIRIC FLOWS SO GEOPHYSICAL RESEARCH LETTERS LA English DT Article ID PHASE-TRANSITIONS; CREEP LAWS; CONVECTION AB We have studied the effects of rheological boundaries in the upper mantle on the dynamics of inducing pulsating diapiric plumes. We have compared the effects due to shallower rheological interfaces in the upper mantle on the timescales of the pulsations. Comparing with a basic model with a rheological interface at 670 km depth, we find that timescales between pulsations can be reduced considerably down to a few million years by adding another rheological boundary at 400 km depth. These results suggest that short timescale diapiric flows may be generated from relatively stationary upwellings from the lower mantle because of the presence of rheological boundaries in the shallow upper mantle. C1 UNIV MINNESOTA,ARMY HIGH PERFORMANCE COMP RES CTR,MINNEAPOLIS,MN 55415. UNIV MINNESOTA,MINNESOTA SUPERCOMP INST,MINNEAPOLIS,MN 55415. RP VANKEKEN, PE (reprint author), UNIV UTRECHT,DEPT THEORET GEOPHYS,POB 80-021,3508 TA UTRECHT,NETHERLANDS. NR 22 TC 10 Z9 10 U1 0 U2 0 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 SN 0094-8276 J9 GEOPHYS RES LETT JI Geophys. Res. Lett. PD SEP 15 PY 1993 VL 20 IS 18 BP 1927 EP 1930 DI 10.1029/93GL01768 PG 4 WC Geosciences, Multidisciplinary SC Geology GA LX651 UT WOS:A1993LX65100010 ER PT J AU BRUCE, CW JELINEK, AV HALONEN, RM STEHLING, MJ PEDERSEN, JC WATERMAN, PC AF BRUCE, CW JELINEK, AV HALONEN, RM STEHLING, MJ PEDERSEN, JC WATERMAN, PC TI MILLIMETER WAVELENGTH ATTENUATION EFFICIENCIES OF FIBROUS AEROSOLS SO JOURNAL OF APPLIED PHYSICS LA English DT Article AB Extinction cross sections normalized to particle volume for two fibrous graphitic aerosols were measured at 0.319 cm (94 GHz) and 0.857 cm (35 GHz). Characterization of the aerosol was performed using several techniques, that is, dosimetrically, through time correlation of millimeter wavelength extinction signals with scattered radiation at much shorter wavelengths, through time correlation with a nearly colinear measurement of extinction at visible wavelengths and using a purpose-built time resolved particle collector system. Results compare well with existing detailed theory. C1 NEW MEXICO STATE UNIV,PHYS SCI LAB,LAS CRUCES,NM 88003. PEDERSEN RES,NEWBURYPORT,MA 01950. RP BRUCE, CW (reprint author), USA,ATMOSPHER SCI LAB,WHITE SANDS MISSILE RANGE,NM 88002, USA. NR 9 TC 7 Z9 7 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD SEP 15 PY 1993 VL 74 IS 6 BP 3688 EP 3691 DI 10.1063/1.354512 PG 4 WC Physics, Applied SC Physics GA LY328 UT WOS:A1993LY32800010 ER PT J AU WARREN, WL KANICKI, J ROBERTSON, J POINDEXTER, EH MCWHORTER, PJ AF WARREN, WL KANICKI, J ROBERTSON, J POINDEXTER, EH MCWHORTER, PJ TI ELECTRON-PARAMAGNETIC-RESONANCE INVESTIGATION OF CHARGE TRAPPING CENTERS IN AMORPHOUS-SILICON NITRIDE FILMS SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID INDUCED METASTABLE DEFECTS; NITROGEN DANGLING-BOND; CORRELATION-ENERGY; THIN-FILMS; STATES; SEMICONDUCTORS; TRANSISTORS; TRAPS; MODEL; SIO2 AB We have explored the nature of the silicon dangling-bond center in amorphous hydrogenated silicon nitride (a-SiN(x):H) thin films, and its relationship to the charge trapping centers using electron paramagnetic resonance (EPR) and capacitance-voltage (C-V) measurements. We have investigated the quantitative relationship between the concentration of silicon dangling bonds using EPR and the concentration of charge traps, measured by C-V measurements, for both UV-illuminated and unilluminated a-SiN(x):H thin films subjected to both electron and hole injection sequences. A theoretical framework for our results is also discussed. These results continue to support a model in which the Si dangling bond is a negative-U defect in silicon nitride, and that a change in charge state of preexisting positively and negatively charged Si sites is responsible for the trapping phenomena observed in these thin film dielectrics. C1 IBM CORP,THOMAS J WATSON RES CTR,DIV RES,YORKTOWN HTS,NY 10598. NATL POWER LABS,LEATHERHEAD KT22 7SE,SURREY,ENGLAND. USA,RES LAB,ELECTR & POWER SOURCES DIRECTORATE,FT MONMOUTH,NJ 07703. SANDIA NATL LABS,DEPT SILICON TECHNOL,ALBUQUERQUE,NM 87185. RP WARREN, WL (reprint author), SANDIA NATL LABS,ADV MAT LAB,ALBUQUERQUE,NM 87106, USA. RI Kanicki, Jerzy/E-2753-2016 OI Kanicki, Jerzy/0000-0002-3649-8360 NR 55 TC 74 Z9 75 U1 3 U2 11 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD SEP 15 PY 1993 VL 74 IS 6 BP 4034 EP 4046 DI 10.1063/1.355315 PG 13 WC Physics, Applied SC Physics GA LY328 UT WOS:A1993LY32800060 ER PT J AU KUBICEK, CP MESSNER, R GRUBER, F MANDELS, M KUBICEKPRANZ, EM AF KUBICEK, CP MESSNER, R GRUBER, F MANDELS, M KUBICEKPRANZ, EM TI TRIGGERING OF CELLULASE BIOSYNTHESIS BY CELLULOSE IN TRICHODERMA-REESEI - INVOLVEMENT OF A CONSTITUTIVE, SOPHOROSE-INDUCIBLE, GLUCOSE-INHIBITED BETA-DIGLUCOSIDE PERMEASE SO JOURNAL OF BIOLOGICAL CHEMISTRY LA English DT Article ID CELL-WALLS; SYSTEM; ENDOGLUCANASE; CELLOBIOSE; SECRETION; TRANSPORT; MECHANISM; GENES AB We prepared [U-C-14]cellobiose by cultivating Acetobacter pasteurianus in the presence of [U-C-14]glucose and hydrolyzing the [U-C-14]cellulose formed with beta-glucosidase-free cellulase from Trichoderma reesei. This C-14-labeled cellobiose was used to investigate the presence of an uptake system for cellobiose in T. reesei. Evidence was obtained for the presence of a high affinity (K(m) for cellobiose 0.3 muM) but low activity (2.5 milliunits/mg fungal dry weight) cellobiose permease. The permease is formed constitutively, but higher levels are formed after addition of sophorose (glucosyl-beta-1,2-diglucoside), a reputed cellulase inducer. The permease appears to be specific for beta-diglucosides, as the uptake of [U-C-14]cellobiose is inhibited by sophorose, gentiobiose (glucosyl-,beta-1,3-glucoside), and cellobiose. Under these conditions, cellooligodextrines (n, 4-7; final concentration, 1 mM) are not inhibitors. Glucose, but no other monosaccharides, inhibits the permease. The hypersecretory mutant T. reesei RUT C-30 exhibits elevated permease activities, whereas in T. reesei QM 9979, a mutant strain defective in the induction of cellulases by cellulose or sophorose, strongly reduced permease activities were demonstrated. The results stress a hitherto not recognized point of control in the induction of cellulases by T. reesei at the level of uptake of cellulose oligosaccharides. C1 USA,NATICK RES & DEV LABS,NATICK,MA 01760. RP KUBICEK, CP (reprint author), VIENNA TECH UNIV,MIKROBIELLE BIOCHEM ABT,INST BIOCHEM TECHNOL & MIKROBIOL,A-1060 VIENNA,AUSTRIA. NR 28 TC 63 Z9 67 U1 0 U2 1 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0021-9258 J9 J BIOL CHEM JI J. Biol. Chem. PD SEP 15 PY 1993 VL 268 IS 26 BP 19364 EP 19368 PG 5 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA LW819 UT WOS:A1993LW81900035 PM 8366083 ER PT J AU WONG, NCW RAYMOND, J CARR, FE AF WONG, NCW RAYMOND, J CARR, FE TI A LIVER-SPECIFIC NUCLEAR-PROTEIN REPRESSES TRANSCRIPTION OF THE S14 GENE IN-VITRO AND IN-VIVO SO JOURNAL OF BIOLOGICAL CHEMISTRY LA English DT Article ID HORMONE-RESPONSIVE GENE; THYROID-HORMONE; RAT-LIVER; MESSENGER-RNA; EXPRESSION; HYPOTHYROIDISM; PROMOTER; BINDING; REGION; LEVEL AB P1 is a nuclear protein found exclusively in rat liver and binds to a motif that spans nucleotides -310 to -288 of the thyroid hormone responsive gene, S14. We expect P1 to play an important role in regulating gene expression because the binding motif for this factor is contained within a DNase I-hypersensitive site of S14 chromatin. In this report, we have attempted to define the function of P1 by correlating its DNA binding activity with levels of mRNA-S 14 in response to aging and obesity. Results of all studies revealed inverse relationships between the activity of P1 and levels of mRNA-S14, thus suggesting that P1 may function as a repressor of S14 gene expression. Accordingly, we tested the repressor hypothesis using cell-free transcription and transient transfection assays to measure the activity of reporter constructs with and without the P1 binding motif. In the presence of the P1 motif, S14 promoter activity was repressed and the negative effect on gene transcription was further enhanced by thyroid hormone. These observations are consistent with P1 being a repressor of S14 gene transcription. C1 UNIV CALGARY,DEPT MED,CALGARY T2N 4N1,AB,CANADA. UNIV CALGARY,DEPT MED BIOCHEM,CALGARY T2N 4N1,AB,CANADA. WALTER REED ARMY MED CTR,KYLE METAB UNIT,WASHINGTON,DC 20307. NR 28 TC 3 Z9 3 U1 0 U2 0 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0021-9258 J9 J BIOL CHEM JI J. Biol. Chem. PD SEP 15 PY 1993 VL 268 IS 26 BP 19431 EP 19435 PG 5 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA LW819 UT WOS:A1993LW81900045 PM 7690031 ER PT J AU SHOOP, BL AF SHOOP, BL TI 2ND-ORDER CASCADED OPTICAL ERROR DIFFUSION MODULATORS FOR OVERSAMPLED ANALOG-TO-DIGITAL CONVERTERS SO OPTICS COMMUNICATIONS LA English DT Article AB In an oversampled A/D converter, oversampling, negative feedback, and linear filtering techniques are used to trade sampling speed for improved amplitude resolution. In order to achieve higher resolution with this type of converter, a higher-order noise shaping filter is required. However, as a result of the negative feedback architecture, higher-order filters can cause limit cycle oscillations and therefore instabilities in the converter. Cascaded oversampling modulators offer a means of achieving higher resolution without the stability problems associated with single-loop modulators. The feasibility of a two-stage cascaded optical oversampled modulator is investigated and found to provide second-order performance with relatively modest constraints on stage-to-stage matching tolerances. RP SHOOP, BL (reprint author), US MIL ACAD,DEPT ELECT ENGN,PHOTON RES CTR,W POINT,NY 10996, USA. NR 12 TC 7 Z9 7 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0030-4018 J9 OPT COMMUN JI Opt. Commun. PD SEP 15 PY 1993 VL 102 IS 1-2 BP 125 EP 132 DI 10.1016/0030-4018(93)90483-L PG 8 WC Optics SC Optics GA LW017 UT WOS:A1993LW01700022 ER PT J AU ATHALE, RA RAJ, K SAVKAR, VA AF ATHALE, RA RAJ, K SAVKAR, VA TI FULLY PARALLEL ANALOG OPTICAL CALCULATION OF MULTIPLE OUTER PRODUCTS (VOL 18, PG 989, 1993) SO OPTICS LETTERS LA English DT Correction, Addition C1 GEORGE MASON UNIV,DEPT ELECT & COMP ENGN,FAIRFAX,VA 22030. RP ATHALE, RA (reprint author), US,ARMY RES LABS,OPT SIGNAL PROC GRP,ADELPHI,MD 20738, USA. NR 1 TC 0 Z9 0 U1 0 U2 1 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0146-9592 J9 OPT LETT JI Opt. Lett. PD SEP 15 PY 1993 VL 18 IS 18 BP 1573 EP 1573 DI 10.1364/OL.18.001573 PG 1 WC Optics SC Optics GA LW885 UT WOS:A1993LW88500032 PM 19823450 ER PT J AU BRYANT, GW AF BRYANT, GW TI ELECTRONS IN COUPLED VERTICAL QUANTUM DOTS - INTERDOT TUNNELING AND COULOMB CORRELATION SO PHYSICAL REVIEW B LA English DT Article ID DOUBLE-BARRIER HETEROSTRUCTURES; ZERO-DIMENSIONAL STATES; MAGNETIC-FIELD; WELL; SPECTROSCOPY; CONFINEMENT; DIODES AB Interdot tunneling, lateral confinement, and Coulomb correlation determine how charge is transferred when a bias is applied between the dots in coupled quantum dot systems. The effective-mass Schrodinger equation for interacting electrons confined in coupled vertical double-dot systems is solved to study interdot charge transfer. The configuration-interaction method is used to explicitly include intradot and interdot electron correlation. The energy spectra, charge densities, and correlation functions for interacting two-electron systems in coupled dots are presented as functions of the applied bias between the dots. In small dots with strong lateral confinement, where the Coulomb energies are larger than the interdot tunneling resonances, the total charge on a dot changes in integer jumps as a bias is applied. Lateral correlation is inhibited by strong lateral confinement and charge tunneling out of a dot is uncorrelated to the charge remaining in the dot. The dot charge changes more smoothly with applied bias when the dots are more strongly coupled by interdot tunneling or in larger dots where intradot correlation causes large intradot charge separation, which reduces charging energies and suppresses the Coulomb blockade of charge transfer. In large dots, charge tunneling out of a dot remains strongly correlated to charge left on the dot. To study charging in vertical quantum dot resonant-tunneling structures, the dots must be wide enough that charging energies are large compared to the single-particle-level spacings, but not so large that intradot correlation strongly suppresses the charging energies and Coulomb blockade effects. RP BRYANT, GW (reprint author), USA,RES LAB,MICROPHOTON DEVICES BRANCH,ADELPHI,MD 20783, USA. NR 33 TC 65 Z9 65 U1 0 U2 5 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0163-1829 J9 PHYS REV B JI Phys. Rev. B PD SEP 15 PY 1993 VL 48 IS 11 BP 8024 EP 8034 DI 10.1103/PhysRevB.48.8024 PG 11 WC Physics, Condensed Matter SC Physics GA LY665 UT WOS:A1993LY66500033 ER PT J AU GOODNICK, SM WU, JC WYBOURNE, MN SMITH, DD AF GOODNICK, SM WU, JC WYBOURNE, MN SMITH, DD TI HOT-ELECTRON BISTABILITY IN QUANTUM-DOT STRUCTURES SO PHYSICAL REVIEW B LA English DT Note ID ENERGY-LOSS RATES; MULTILAYER HETEROSTRUCTURES; HETEROJUNCTIONS; RESISTANCE; TRANSPORT; MECHANISM AB We present a theoretical analysis of hot-electron bistability in quantum-dot structures. An energy balance approach is used to demonstrate the existence of negative differential conductance due to thermal runaway of the carriers in the dot structure. This runaway is shown to arise from heating of carriers in the quantum dot by incident electrons injected over the barrier of the input constriction. Excellent agreement is obtained with recent experimental evidence of bistability in the current-voltage characteristics of laterally confined quantum dots [J. C. Wu, M. N. Wybourne, C. Berven, S. M. Goodnick, and D. D. Smith, Appl. Phys. Lett. 61, 1 (1992)]. C1 UNIV OREGON, DEPT PHYS, EUGENE, OR 97403 USA. USA, RES LAB,ELECTR & POWER SOURCES DIRECTORATE,MS, AMSRL EP EF, FT MONMOUTH, NJ 07703 USA. RP OREGON STATE UNIV, DEPT ELECT & COMP ENGN, CORVALLIS, OR 97331 USA. NR 21 TC 12 Z9 12 U1 0 U2 1 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 2469-9950 EI 2469-9969 J9 PHYS REV B JI Phys. Rev. B PD SEP 15 PY 1993 VL 48 IS 12 BP 9150 EP 9153 DI 10.1103/PhysRevB.48.9150 PG 4 WC Physics, Condensed Matter SC Physics GA LY959 UT WOS:A1993LY95900079 ER PT J AU LEAVITT, RP TOWNER, FJ AF LEAVITT, RP TOWNER, FJ TI DETERMINATION OF THE LATTICE-PARAMETER AND POISSON RATIO FOR ALAS VIA HIGH-RESOLUTION X-RAY-DIFFRACTION STUDIES OF EPITAXIAL-FILMS SO PHYSICAL REVIEW B LA English DT Note ID ALXGA1-XAS; LAYERS; GAAS AB We have used high-resolution x-ray-diffraction studies of partially relaxed AlAs films grown on GaAs to determine the lattice parameter [5.661 20(6) angstrom at 300 K, assuming a GaAs lattice parameter of 5.653 25 angstrom] and the Poisson ratio [0.328(4)] of AlAs. Our results agree with (but are an order of magnitude more precise than) previous AlAs lattice-parameter measurements but contradict recent results obtained from measurements on AlxGa1-xAs films. Properly reinterpreted, the latter measurements, taken together with our results, imply that the AlxGa1-xAs lattice parameter deviates from Vegard's law. C1 MARTIN MARIETTA CORP LABS,BALTIMORE,MD 21227. RP LEAVITT, RP (reprint author), USA,RES LAB,2800 POWDER MILL RD,ADELPHI,MD 20783, USA. NR 20 TC 14 Z9 14 U1 0 U2 0 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0163-1829 J9 PHYS REV B JI Phys. Rev. B PD SEP 15 PY 1993 VL 48 IS 12 BP 9154 EP 9157 DI 10.1103/PhysRevB.48.9154 PG 4 WC Physics, Condensed Matter SC Physics GA LY959 UT WOS:A1993LY95900080 ER PT J AU TYOR, WR POWER, C GENDELMAN, HE MARKHAM, RB AF TYOR, WR POWER, C GENDELMAN, HE MARKHAM, RB TI A MODEL OF HUMAN-IMMUNODEFICIENCY-VIRUS ENCEPHALITIS IN SCID MICE SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article ID CENTRAL-NERVOUS-SYSTEM; MONONUCLEAR PHAGOCYTES; HIV-1 INFECTION; IMMUNE-SYSTEM; HTLV-III; AIDS; EXPRESSION; TYPE-1; CYTOKINES; COMPLEX AB Human immunodeficiency virus (HIV)-associated dementia complex is a common and devastating manifestation of the late phases of HIV infection. The pathogenesis of dementia complex is poorly understood and effective treatments have not been developed, in part because of the lack of an appropriate animal model. Mice with severe combined immunodeficiency (scid mice), which accept xenografts without rejection, were intracerebrally inoculated with human peripheral blood mononuclear cells and HIV. One to 4 weeks after inoculation, the brains of these mice contained human macrophages (some of which were HIV p24 antigen positive), occasional multinucleated cells, and striking gliosis by immunocytochemical staining. Human macrophages also were frequently positive for tumor necrosis factor type a and occasionally for interleukin 1 and VLA-4. Cultures of these brains for HIV were positive. Generally, human macrophages were not present in the brains of control mice, nor was significant gliosis, and HIV was not recovered from mice that received HIV only intracerebrally. Pathologically, this model of HIV encephalitis in scid mice resembles HIV encephalitis in humans and the data suggest that the activation of macrophages by infection with HIV results in their accumulation and persistence in brain and in the development of gliosis. This model of HIV encephalitis should provide insights into the pathogenesis and treatment of this disorder. C1 JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROL,BALTIMORE,MD 21205. WALTER REED ARMY INST RES,DEPT CELLULAR IMMUNOL,ROCKVILLE,MD 20850. JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,DEPT IMMUNOL & INFECT DIS,BALTIMORE,MD 21205. RI Power, Christopher/C-7181-2013; OI Power, Christopher/0000-0002-5131-9711 FU NIAID NIH HHS [AI28748, AI29163]; NINDS NIH HHS [5NPO1-NS-26643] NR 38 TC 91 Z9 92 U1 0 U2 1 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD SEP 15 PY 1993 VL 90 IS 18 BP 8658 EP 8662 DI 10.1073/pnas.90.18.8658 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA LX750 UT WOS:A1993LX75000075 PM 8378344 ER PT J AU RAO, DVGLN ARANDA, FJ WILEY, BJ AKKARA, JA KAPLAN, DL ROACH, JF AF RAO, DVGLN ARANDA, FJ WILEY, BJ AKKARA, JA KAPLAN, DL ROACH, JF TI MIRRORLESS ALL-OPTICAL BISTABILITY IN BACTERIORHODOPSIN SO APPLIED PHYSICS LETTERS LA English DT Article ID FILMS AB We report direct observations of all-optical mirrorless bistability associated with saturable absorption in three kinds of bacteriorhodopsin (BR) samples: wild-type BR in water solution and dispersed in thin films of a polymer matrix as well as water solution of the genetically engineered mutant BR(D96N). The experiments are carried out with picosecond pulses at 532 nm. The values measured for the saturation intensity are explained in terms of the relaxation of the excited M state population to the B state of the BR photocycle for the three kinds of samples studied. C1 USA,NATICK RES DEV & ENGN CTR,NATICK,MA 01760. RP RAO, DVGLN (reprint author), UNIV MASSACHUSETTS,DEPT PHYS,BOSTON,MA 02125, USA. RI Rao, Devulapalli/L-8863-2015 NR 15 TC 16 Z9 17 U1 0 U2 1 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD SEP 13 PY 1993 VL 63 IS 11 BP 1489 EP 1491 DI 10.1063/1.109665 PG 3 WC Physics, Applied SC Physics GA LX161 UT WOS:A1993LX16100013 ER PT J AU BIRDWELL, BG HERBERS, JE KROENKE, K AF BIRDWELL, BG HERBERS, JE KROENKE, K TI EVALUATING CHEST PAIN - THE PATIENTS PRESENTATION STYLE ALTERS THE PHYSICIANS DIAGNOSTIC-APPROACH SO ARCHIVES OF INTERNAL MEDICINE LA English DT Article ID CORONARY-ARTERY DISEASE; SIMULATED PATIENTS; PROBABILITY; MANAGEMENT; SKILLS; BIAS AB Backgrounds: Clinical prediction rules rely largely on objective data to estimate coronary artery disease (CAD) likelihood. However, characterization of chest pain, which is central to such prediction rules, depends in part on a physician's subjective judgments. We performed a clinical trial to assess the influence of the patient's presentation style on the physician's approach to evaluating chest pain. Methods: Forty-four internists were randomized to one of three treatment groups. Two groups viewed videotapes of the same actress performing the role of a patient in a scripted physician-patient interview in two distinct styles: one group saw a 'histrionic'' characterization, the other a ''businesslike' portrayal. The interviewer was not seen or heard by the subjects; they saw only words on the screen. The third group read a verbatim transcript of the interview. After their initial CAD-likelihood estimates and impressions of probable cause for the patient's symptoms, which were based on history only, the participants in all three groups were given the same laboratory data and a second CAD-likelihood estimate was made. Finally, recommendations for further workup were elicited. Results: Initial diagnostic impressions differed dramatically: a cardiac cause was suspected by 50% of physicians viewing the businesslike portrayal but by only 13% of those viewing the histrionic portrayal. Likewise, those viewing the histrionic and businesslike videos provided different CAD-likelihood estimates initially (10% vs 20%). However, after the patient's laboratory data were revealed, the difference in CAD-likelihood estimates was no longer significant. Despite their making a similar risk appraisal after receiving all of the data, internists viewing the histrionic portrayal were far less likely to pursue a cardiac workup (53% vs 93%). Conclusions: Although physicians may evaluate patients who have the same history word for word and the same laboratory data and whom they regard as having nearly identical likelihoods of CAD, the physician's ultimate diagnostic approach can be profoundly affected by the patient's presentation style. C1 UNIFORMED SERV UNIV HLTH SCI,DEPT MED,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,DEPT MED,WASHINGTON,DC 20307. RP BIRDWELL, BG (reprint author), UNIV OKLAHOMA HLTH SCI CTR,HLTH SCI CTR,DEPT MED,DIV CARDIOVASC,5SP ROOM 300,OKLAHOMA CITY,OK 73104, USA. NR 14 TC 56 Z9 56 U1 0 U2 4 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0003-9926 J9 ARCH INTERN MED JI Arch. Intern. Med. PD SEP 13 PY 1993 VL 153 IS 17 BP 1991 EP 1995 DI 10.1001/archinte.153.17.1991 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA LY513 UT WOS:A1993LY51300004 PM 8357283 ER PT J AU SHUKITTHALE, B STILLMAN, MJ LEVY, A DEVINE, JA LIEBERMAN, HR AF SHUKITTHALE, B STILLMAN, MJ LEVY, A DEVINE, JA LIEBERMAN, HR TI NIMODIPINE PREVENTS THE IN-VIVO DECREASE IN HIPPOCAMPAL EXTRACELLULAR ACETYLCHOLINE PRODUCED BY HYPOBARIC HYPOXIA SO BRAIN RESEARCH LA English DT Article DE NIMODIPINE; ACETYLCHOLINE; CHOLINE; HYPOXIA; ALTITUDE; MICRODIALYSIS ID CALCIUM-ANTAGONIST NIMODIPINE; IMPAIRED SYNTHESIS; RATS; BRAIN; MILD; MICRODIALYSIS; METABOLISM; BEHAVIOR; RELEASE; ANOXIA AB Hypoxia decreases acetylcholine (ACh) synthesis and release in vitro, and ACh synthesis in vivo; however, its effect on extracellular concentration of ACh in vivo is not known. The calcium channel blocker nimodipine is a cerebrovascular dilator which also increases extracellular ACh in vivo. Therefore, it may provide protection from the effects of hypobaric hypoxia on the cholinergic system either via its effects on vascular function or by direct action on the nervous system. This study examined the effect of hypobaric hypoxia on extracellular ACh and choline levels, as measured by microdialysis, as well as the effects of nimodipine under hypoxia. Microdialysis guide cannulae were implanted into the hippocampal region of male Fischer rats so that probes would sample from the CA1 and DG regions. Animals were then exposed for eight hours to a simulated altitude of 5,500 m (18,000 ft) or tested at sea level for an equivalent duration. HPLC with electrochemical detection was used for analysis of the dialysates. At 5,500 m extracellular ACh levels in the placebo-treated group were significantly lower than the sea level group values. This decrement was reversed by nimodipine administered i.p. immediately preceding altitude ascent (10 mg/kg) and 250 min post-altitude ascent (10 mg/kg). These data suggest that nimodipine may provide protection from the detrimental effects of hypoxia on hippocampal cholinergic function. C1 GEOCENTERS INC,NEWTON,MA 02159. BOSTON UNIV,DEPT PSYCHOL,BOSTON,MA 02215. ISRAEL INST BIOL RES,DEPT PHARMACOL,IL-70450 NESS ZIONA,ISRAEL. RP SHUKITTHALE, B (reprint author), USA,ENVIRONM MED RES INST,DIV MIL PERFORMANCE & NEUROSCI,KANSAS ST,NATICK,MA 01760, USA. NR 34 TC 21 Z9 21 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0006-8993 J9 BRAIN RES JI Brain Res. PD SEP 10 PY 1993 VL 621 IS 2 BP 291 EP 295 DI 10.1016/0006-8993(93)90118-7 PG 5 WC Neurosciences SC Neurosciences & Neurology GA LW056 UT WOS:A1993LW05600014 PM 8242341 ER PT J AU KNAUS, WA HARRELL, FE FISHER, CJ WAGNER, DP OPAL, SM SADOFF, JC DRAPER, EA WALAWANDER, CA CONBOY, K GRASELA, TH AF KNAUS, WA HARRELL, FE FISHER, CJ WAGNER, DP OPAL, SM SADOFF, JC DRAPER, EA WALAWANDER, CA CONBOY, K GRASELA, TH TI THE CLINICAL-EVALUATION OF NEW DRUGS FOR SEPSIS - A PROSPECTIVE-STUDY DESIGN BASED ON SURVIVAL ANALYSIS SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Article ID ILL HOSPITALIZED ADULTS; ORGAN-SYSTEM FAILURE; GRAM-NEGATIVE SEPSIS; REGRESSION-MODELS; SEPTIC SHOCK; PROPORTIONAL HAZARDS; MONOCLONAL-ANTIBODY; MORTALITY; TRIAL; DEFINITIONS AB Objective.- To develop a survival model and severity assessment method to estimate the 28-day mortality risk for patients with sepsis syndrome entering phase 2 and 3 drug evaluations. Design.- Retrospective analysis of intensive care unit admissions with sepsis syndrome by means of log-normal regression to identify risk factors for 28-day mortality. Prospective application of the model to patients with gram-negative infection meeting sepsis syndrome criteria from separate data collection (validation group). Patients.- A total of 58 737 intensive care unit admissions at 107 hospitals in the United States and Western Europe screened to yield 1195 patients meeting entry criteria for the sepsis syndrome study for the original model; 295 hospitalized patients with gram-negative infection meeting criteria for sepsis syndrome for validation. Main Outcome Measures.- Survival time and mortality at 28 days after fulfillment of the sepsis syndrome criteria. Results.- Acute physiologic abnormalities were the most important prognostic factors influencing outcome (82% of total chi2). Specific disease resulting in intensive care unit admission and the time the patient was in the hospital and intensive care unit before qualification were also independent risks, as were age and a clinical history of cirrhosis. The model's overall classification accuracy was a Somers' Dyx of .52 (rank correlation between predicted risk and 28-day mortality) (receiver operating characteristic area, 0.76), with equal accuracy (Dyx=.59; receiver operating characteristic area, 0.80) in the independent group of patients. Conclusions.- We created an accurate independent estimate for 28-day mortality risk for patients with sepsis syndrome (severe sepsis). This estimate could improve the evaluation of new drugs by investigating whether the drug's benefit varies by patient risk and then determining the amount of benefit for individual patients. C1 DUKE UNIV, MED CTR, DIV BIOMETRY, DURHAM, NC 27710 USA. CLEVELAND CLIN EDUC FDN, CRIT CARE RES UNIT, CLEVELAND, OH 44106 USA. BROWN UNIV, PROVIDENCE, RI 02912 USA. WALTER REED ARMY INST RES, WASHINGTON, DC 20307 USA. APACHE MED SYST INC, WASHINGTON, DC USA. SUNY Buffalo, CTR PHARMACOEPIDEMIOL RES, BUFFALO, NY 14260 USA. RP KNAUS, WA (reprint author), GEORGE WASHINGTON UNIV, MED CTR, ICU, RES UNIT, 2300 K ST NW, WASHINGTON, DC 20037 USA. FU AHRQ HHS [HSO 7137] NR 36 TC 148 Z9 149 U1 0 U2 2 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD SEP 8 PY 1993 VL 270 IS 10 BP 1233 EP 1241 DI 10.1001/jama.270.10.1233 PG 9 WC Medicine, General & Internal SC General & Internal Medicine GA LV649 UT WOS:A1993LV64900031 PM 8355388 ER PT J AU BRYANT, GW BRADSHAW, JL LEAVITT, RP TOBIN, MS PHAM, JT AF BRYANT, GW BRADSHAW, JL LEAVITT, RP TOBIN, MS PHAM, JT TI DETERMINING BAND OFFSETS WITH TRIPLE QUANTUM-WELL STRUCTURES SO APPLIED PHYSICS LETTERS LA English DT Article ID HETEROSTRUCTURES; DISCONTINUITIES; ELECTRON; ALGAAS AB Coupled triple quantum-well GaAs/AlGaAs heterostructures have been designed to exhibit simultaneous electron and hole tunneling from the central well to opposite side wells at a fixed applied bias. Band offset is the critical parameter for the design of structures with simultaneous resonances. Photocurrent measurements reveal which triple quantum-well structures exhibit simultaneous resonances. A band offset ratio near 62:38 is required to correctly engineer structures with simultaneous resonances. RP BRYANT, GW (reprint author), USA,RES LAB,MICROPHOTON DEVICES BRANCH,ADELPHI,MD 20783, USA. RI Bradshaw, John/E-8330-2011 NR 15 TC 11 Z9 11 U1 1 U2 2 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD SEP 6 PY 1993 VL 63 IS 10 BP 1357 EP 1359 DI 10.1063/1.109676 PG 3 WC Physics, Applied SC Physics GA LW183 UT WOS:A1993LW18300020 ER PT J AU NOPKESORN, T MASTRO, TD SANGKHAROMYA, S SWEAT, M SINGHARAJ, P LIMPAKARNJANARAT, K GAYLE, HD WENIGER, BG AF NOPKESORN, T MASTRO, TD SANGKHAROMYA, S SWEAT, M SINGHARAJ, P LIMPAKARNJANARAT, K GAYLE, HD WENIGER, BG TI HIV-1 INFECTION IN YOUNG MEN IN NORTHERN THAILAND SO AIDS LA English DT Article DE HIV-1; THAILAND; ASIA; HETEROSEXUAL TRANSMISSION; SEXUALLY TRANSMITTED DISEASES; PROSTITUTION; CONDOM USE ID RISK-FACTORS; IMMUNODEFICIENCY AB Objectives: To determine risk factors for HIV-1 infection in young men in northern Thailand, Methods: At enrollment into a prospective study, data were collected from a self-administered questionnaire and serologic testing on a cohort of 1115 young men selected by lottery for conscription. Results: The overall HIV-1 infection rate was 6.9%; however, the rate was 15.3% among the 387 (34.7%) men who had been living in the upper north subregion of Thailand compared with 2.5% for the remaining 728 men (P < 0.001). A history of sex with female prostitutes was reported by 74.7% of men and increased frequency of this type of sex was highly associated with HIV-1 infection and a history of sexually transmitted disease (STD) symptoms (chi2 for trend, P < 0.001). In stratified and multivariate analyses, however, history of STD symptoms, reported by 42.5% of the cohort, was most strongly associated with HIV-1 infection. Only 42.8% of men who reported sex with prostitutes had used condoms more than half the time. Conclusions: Young men in the general population in northern Thailand are at high risk for HIV-1 infection via sex with female prostitutes; STD are highly associated with HIV-1 infection. Increasing condom use and controlling STD should be immediate goals of HIV control programs. C1 SOMDEJ PRANARESUAN MAHARAJ HOSP,PHITSANULOKE,THAILAND. HIV AIDS COLLABORAT,BANGKOK,THAILAND. ARMED FORCES RES INST MED SCI,BANGKOK,THAILAND. CTR DIS CONTROL & PREVENT,NATL CTR INFECT DIS,DIV HIV AIDS,ATLANTA,GA. OI Weniger, Bruce/0000-0002-5450-5464 NR 10 TC 86 Z9 88 U1 0 U2 0 PU RAPID SCIENCE PUBLISHERS PI LONDON PA 2-6 BOUNDARY ROW, LONDON, ENGLAND SE1 8NH SN 0269-9370 J9 AIDS JI Aids PD SEP PY 1993 VL 7 IS 9 BP 1233 EP 1239 DI 10.1097/00002030-199309000-00013 PG 7 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA LV706 UT WOS:A1993LV70600013 PM 8216981 ER PT J AU KIM, JH MOSCA, JD VAHEY, MT MCLINDEN, RJ BURKE, DS REDFIELD, RR AF KIM, JH MOSCA, JD VAHEY, MT MCLINDEN, RJ BURKE, DS REDFIELD, RR TI CONSEQUENCES OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 SUPERINFECTION OF CHRONICALLY INFECTED-CELLS SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Article ID MURINE LEUKEMIA VIRUSES; HTLV-III/LAV ENVELOPE; NONCYTOPATHIC INFECTION; DOWN-REGULATION; RNA-SYNTHESIS; SURFACE CD4; T4 ANTIGEN; HIV TYPE-1; VIRAL-DNA; RETROVIRUS AB Infection of T cell lines by the type 1 human immunodeficiency virus (HIV-1) is associated with downregulation of the CD4 receptor and resistance to further HIV-1 infection, the phenomenon of viral interference. The ACH2 cell line, a model for chronic HIV-1 infection, possesses a single integrated copy of the HIV-1 strain LAI, is essentially CD4 negative, and can be induced to make virus by a variety of stimuli. We utilized the known sequence differences between HIV(LAI) and HIV(RF) to devise a polymerase chain reaction (PCR) strategy that permits reliable and quantitative discrimination between the two strains. We demonstrate that ACH2 cells can be superinfected by HIV(RF) at a frequency of 60-300 HIV(RF) genomes/10(4) ACH2 cells and that the frequency of superinfection appears to increase with time. Reverse transcription of ACH2 mRNA from days 13, 27, and 38 postinfection allowed a similar PCR strategy (RT-PCR) to be used to analyze full-length HIV(RF-) and HIV(LAI)-specific transcripts. These data suggested that superinfection of ACH2 with HIV(RF) results in an increase in expression of both HIV(RF) and HIV(LAI) mRNA. From day 13 to day 38 postinfection there was an increase in the relative expression of HIV(RF) compared with HIV(LAI). By day 38, when only 1.1% of HIV DNA sequences were HIV(RF) derived, roughly 80% of the HIV-specific full-length mRNA was HIV(RF) in origin, with a concomitant decrease in HIV(LAI) transcription. C1 HENRY M JACKSON FDN,ROCKVILLE,MD 20850. WALTER REED ARMY INST RES,MIL MED CONSORTIUM APPL RETROVIRAL RES,DIV RETROVIROL,ROCKVILLE,MD 20850. RP KIM, JH (reprint author), WALTER REED ARMY INST RES,MIL MED CONSORTIUM APPL RETROVIRAL RES,DEPT RETROVIRAL RES,ROCKVILLE,MD 20850, USA. OI /0000-0002-5704-8094 NR 39 TC 25 Z9 25 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD SEP PY 1993 VL 9 IS 9 BP 875 EP 882 DI 10.1089/aid.1993.9.875 PG 8 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA MB204 UT WOS:A1993MB20400010 PM 7504936 ER PT J AU KADAKIA, SC PARKER, A CARROUGHER, JG SHAFFER, RT AF KADAKIA, SC PARKER, A CARROUGHER, JG SHAFFER, RT TI ESOPHAGEAL DILATION WITH POLYVINYL BOUGIES, USING A MARKED GUIDEWIRE WITHOUT THE AID OF FLUOROSCOPY - AN UPDATE SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Article ID BALLOON DILATATION; GASTROINTESTINAL STENOSES; ANASTOMOTIC STRICTURES; SELF-BOUGIENAGE; SAVARY-GILLIARD; EDER-PUESTOW; BENIGN; DILATORS; COMPLICATIONS; ENDOSCOPY AB One hundred thirty-eight patients with esophageal stricture underwent polyvinyl bougie dilations whereby American Endoscopy dilators were passed over a marked guidewire that had been placed endoscopically. Fluoroscopy was not utilized during the dilations. The dilations were performed only after the guidewire was properly placed, with 60-cm markings at the incisors, which ensured that the tip of the guidewire was in the antrum. One hundred fourteen patients had benign strictures and 24 had malignant strictures. There were 197 sessions of dilations for a total of 748 individual dilations. In 97 of 138 patients, the guidewire was placed in the antrum under direct vision. The remaining 41 patients had significant esophageal stenosis which prevented passage of the endoscope into the stomach; therefore, the guidewire was placed by advancing it blindly through the stenosis. There were no procedure-related complications. During this period, eight patients were dilated without complications, using fluoroscopic placement of guidewire because endoscopic placement of the guidewire was not considered safe. We conclude that esophageal strictures can be safely dilated in most patients by means of the American Endoscopy dilator system and the marked guidewire without the aid of fluoroscopy. C1 BROOKE ARMY MED CTR,DEPT MED,GASTROENTEROL SERV,SAN ANTONIO,TX. NR 42 TC 18 Z9 18 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD SEP PY 1993 VL 88 IS 9 BP 1381 EP 1386 PG 6 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA LW166 UT WOS:A1993LW16600015 PM 8362835 ER PT J AU BJORNSON, DC HINER, WO POTYK, RP NELSON, BA LOMBARDO, FA MORTON, TA LARSON, LV MARTIN, BP SIKORA, RG CAMMARATA, FA AF BJORNSON, DC HINER, WO POTYK, RP NELSON, BA LOMBARDO, FA MORTON, TA LARSON, LV MARTIN, BP SIKORA, RG CAMMARATA, FA TI EFFECT OF PHARMACISTS ON HEALTH-CARE OUTCOMES IN HOSPITALIZED-PATIENTS SO AMERICAN JOURNAL OF HOSPITAL PHARMACY LA English DT Article DE CLINICAL PHARMACISTS; COSTS; ECONOMICS; HEALTH CARE; HOSPITALS; MORTALITY; PHARMACY, INSTITUTIONAL, HOSPITAL; SURGERY; TEAM ID EDUCATIONAL-METHODS; COST; SERVICES; SYSTEMS; MODEL AB The cost-effectiveness of pharmacists and their effect on inpatient health care outcomes were evaluated. For one year, data were collected on all patients receiving care from general medicine and general surgery teams at Walter Reed Army Medical Center, Washington, D.C. Two of five medicine teams and one of three surgery teams included a pharmacist. Teams that included a pharmacist were compared with teams that did not, in terms of patients' length of stay (LOS), mortality, and drug cost per admission. Data were compared for 3081 patients and collected for another 557 who were not included in the comparative study design. Health care teams that included a pharmacist had a shorter log LOS and lower log drug cost per admission but no difference in mortality. The average cost savings for teams that included a pharmacist was $377 per inpatient admission, and the benefit-to-cost ratio was 6.03:1. The inclusion of pharmacists on health care teams was cost-effective and provided a favorable benefit-to-cost ratio. C1 WALTER REED ARMY MED CTR,PHARM SERV,WASHINGTON,DC 20307. USA,OFF SURGEON GEN,FALLS CHURCH,VA. WALTER REED ARMY MED CTR,PHARM SERV,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,HEMATOL ONCOL PHARM TREATMENT SECT,WASHINGTON,DC 20307. RP BJORNSON, DC (reprint author), DRAKE UNIV,COLL PHARM & HLTH SCI,28TH & FOREST,DES MOINES,IA 50311, USA. NR 18 TC 94 Z9 96 U1 2 U2 6 PU AMER SOC HEALTH-SYSTEM PHARMACISTS PI BETHESDA PA 7272 WISCONSIN AVE, BETHESDA, MD 20814 SN 0002-9289 J9 AM J HOSP PHARM JI Am. J. Hosp. Pharm. PD SEP PY 1993 VL 50 IS 9 BP 1875 EP 1884 PG 10 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA LV305 UT WOS:A1993LV30500013 PM 8135233 ER PT J AU TOWNER, J CARVAJAL, MV MOSCATELLO, D LYTLE, C GALLAGHER, T NEU, RL LACASSIE, Y LAMB, AN AF TOWNER, J CARVAJAL, MV MOSCATELLO, D LYTLE, C GALLAGHER, T NEU, RL LACASSIE, Y LAMB, AN TI ABNORMAL PHENOTYPE ASSOCIATED WITH AN INHERITED AND WITH A DE-NOVO INV DUP(15) MARKER CHROMOSOME - DETECTION OF EUCHROMATIC SEQUENCES USING PROBES FROM THE PWS/AS DELETION REGIONS SO AMERICAN JOURNAL OF HUMAN GENETICS LA English DT Meeting Abstract C1 LOUISIANA STATE UNIV,MED CTR,NEW ORLEANS,LA 70112. CHILDRENS HOSP,NEW ORLEANS,LA. INTEGRATED GENET VIVIGEN,SANTA FE,NM. TRIPLER ARMY MED CTR,HONOLULU,HI 96859. NR 0 TC 1 Z9 1 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0002-9297 J9 AM J HUM GENET JI Am. J. Hum. Genet. PD SEP PY 1993 VL 53 IS 3 SU S BP 612 EP 612 PG 1 WC Genetics & Heredity SC Genetics & Heredity GA LW335 UT WOS:A1993LW33500613 ER PT J AU MECREDY, RL WISWELL, TE HUME, RF AF MECREDY, RL WISWELL, TE HUME, RF TI OUTCOME OF TERM GESTATION NEONATES WHOSE MOTHERS RECEIVED INTRAPARTUM ANTIBIOTICS FOR SUSPECTED CHORIOAMNIONITIS SO AMERICAN JOURNAL OF PERINATOLOGY LA English DT Article AB Intrapartum antibiotics are commonly given to women suspected of having chorioamnionitis. However, there is no consensus regarding management of their babies. To date, there are no data concerning the clinical courses and outcomes of term gestation, ''pretreated'' neonates. We performed a retrospective review to assess the clinical courses of such infants. From 1987 to 1989, chorioamnionitis was diagnosed in 123 women, 102 of whom received intrapartum antibiotics. Of the 86 term gestation infants born to women in the latter group, 63 were completely asymptomatic. When compared with these neonates, the 23 symptomatic infants were more likely to have lower median 1 and 5 minute Apgar scores (3 vs 8 and 7 vs 9, respectively; p <0.0001), higher immature: mature neutrophil ratios on their initial complete blood counts (0.48 vs 0.24; p = 0.0003), and positive urine antigen studies for group B Streptococcus in the presence of negative blood cultures (4 vs 2; p = 0.042). The intrapartum courses of those infants destined to be symptomatic were more likely to be complicated by fetal tachycardia (p = 0.049) and malodorous amniotic fluid (p = 0.005). Since more than 95% of asymptomatic, pretreated, term gestation neonates have a benign clinical course, aggressive evaluation and management of these infants may not be necessary. C1 WALTER REED ARMY MED CTR,DEPT OBSTET & GYNECOL,WASHINGTON,DC 20307. NR 0 TC 19 Z9 19 U1 0 U2 0 PU THIEME MEDICAL PUBL INC PI NEW YORK PA 381 PARK AVE SOUTH, NEW YORK, NY 10016 SN 0735-1631 J9 AM J PERINAT JI Am. J. Perinatol. PD SEP PY 1993 VL 10 IS 5 BP 365 EP 368 DI 10.1055/s-2007-994763 PG 4 WC Obstetrics & Gynecology; Pediatrics SC Obstetrics & Gynecology; Pediatrics GA LY326 UT WOS:A1993LY32600008 PM 8240595 ER PT J AU SCHAUDIES, RP NONCLERCQ, D NELSON, L TOUBEAU, G ZANEN, J HEUSONSTIENNON, JA LAURENT, G AF SCHAUDIES, RP NONCLERCQ, D NELSON, L TOUBEAU, G ZANEN, J HEUSONSTIENNON, JA LAURENT, G TI ENDOGENOUS EGF AS A POTENTIAL RENOTROPHIC FACTOR IN ISCHEMIA-INDUCED ACUTE-RENAL-FAILURE SO AMERICAN JOURNAL OF PHYSIOLOGY LA English DT Article DE EPIDERMAL GROWTH FACTOR; HYPOXIC INJURY; TUBULAR NECROSIS; TUBULAR REGENERATION ID EPIDERMAL GROWTH-FACTOR; RAT-KIDNEY; UNILATERAL NEPHRECTOMY; FACTOR RECEPTOR; TUBULAR CELLS; REGENERATION; INJURY; RECOVERY; REPAIR; GENTAMICIN AB The time course for the increases in soluble renal epidermal growth factor (EGF) after ischemia has been established. These elevated levels of EGF have been compared with the degree of tissue injury as well as the extent of cell proliferation in the recovering tissue. Levels of soluble immunoreactive EGF (irEGF) in control animals were 9.74 +/- 1.1 ng/g wet wt (n = 4-8 for all values) and rose to 83.9 +/- 30 ng/g within 12 h after injury. Soluble irEGF content peaked at 88.8 +/- 15 ng/g at 24 h postinjury and returned to control values by 72 h. We previously reported that trypsin digestion of crude renal membranes (CRM) generates rat EGF that is indistinguishable from that isolated from the submandibular gland. Initial levels of trypsin-releasable membrane-associated irEGF were 439 +/- 26 ng/g. These levels fell to 46.6 +/- 9.6 ng/g at 48 h after injury. The total renal EGF demonstrated an 80% decline 48 h after injury but returned to 50% of the initial values after 72 h representing significant new synthesis of EGF-containing proteins between 48 and 72 h postinjury. Immunohistochemical staining of kidney paraffin sections for EGF immunoreactivity demonstrated staining intensities that paralleled the amount of irEGF in the trypsin-digested CRM fraction, suggesting that the membrane-associated irEGF is the predominant form detected by this technique. Regenerative hyperplasia subsequent to tubular insult was monitored by immunostaining nuclei of S phase cells after pulse labeling with the thymidine analogue 5-bromo-2'-deoxyuridine. Cell proliferation was particularly prominent in the outer stripe of outer medulla of kidneys exposed to ischemia and reached a maximum 19-fold higher than the baseline value) 48 h after reperfusion. Renal cell turnover returned to control values by day 7. The observation that the peak in soluble EGF levels (24 h) precedes the peak in tubular regeneration (48 h) by 24 h is consistent with the hypothesis that EGF is one of the mitogenic signals triggering regenerative hyperplasia after renal injury. C1 WALTER REED ARMY INST RES,DEPT NEPHROL,WASHINGTON,DC 20307. UNIV MONS HAINAUT,HISTOL & EXPTL CYTOL LAB,B-7000 MONS,BELGIUM. RI Laurent, Guy/B-6278-2009; Nonclercq, Denis/B-6455-2009 NR 30 TC 40 Z9 40 U1 0 U2 0 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0002-9513 J9 AM J PHYSIOL JI Am. J. Physiol. PD SEP PY 1993 VL 265 IS 3 BP F425 EP F434 PN 2 PG 10 WC Physiology SC Physiology GA MA186 UT WOS:A1993MA18600087 PM 8214102 ER PT J AU JONES, BH BOVEE, MW HARRIS, JM COWAN, DN AF JONES, BH BOVEE, MW HARRIS, JM COWAN, DN TI INTRINSIC RISK-FACTORS FOR EXERCISE-RELATED INJURIES AMONG MALE AND FEMALE ARMY TRAINEES SO AMERICAN JOURNAL OF SPORTS MEDICINE LA English DT Article AB Physical training-related injuries are common among army recruits and other vigorously active populations, but little is known about their causation. To identify intrinsic risk factors, we prospectively measured 391 army trainees. For 8 weeks of basic training, 124 men and 186 women (79.3%) were studied. They answered questionnaires on past activities and sports participation, and were measured for height, weight, and body fat percentage; 71% of the subjects took an initial army physical training test. Women had a significantly higher incidence of time-loss injuries than men, 44.6% compared with 29.0%. During training, more time-loss injuries occurred among the 50% of the men who were slower on the mile run, 29.0% versus 0.0%. Slower women were likewise at greater risk than faster ones, 38.2% versus 18.5%. Men with histories of inactivity and with higher body mass index were at greater injury risk than other men, as were the shortest women. We conclude that female gender and low aerobic fitness measured by run times are risk factors for training injuries in army trainees, and that other factors such as prior activity levels and stature may affect men and women differently. RP JONES, BH (reprint author), USA,ENVIRONM MED RES INST,DIV OCCUPAT MED,NATICK,MA 01760, USA. NR 0 TC 264 Z9 268 U1 3 U2 102 PU AMER ORTHOPAEDIC SOC SPORT MED PI WALTHAM PA 230 CALVARY STREET, WALTHAM, MA 02154 SN 0363-5465 J9 AM J SPORT MED JI Am. J. Sports Med. PD SEP-OCT PY 1993 VL 21 IS 5 BP 705 EP 710 DI 10.1177/036354659302100512 PG 6 WC Orthopedics; Sport Sciences SC Orthopedics; Sport Sciences GA LY341 UT WOS:A1993LY34100012 PM 8238712 ER PT J AU UHORCHAK, JM WHITE, PM SCULLY, TJ AF UHORCHAK, JM WHITE, PM SCULLY, TJ TI TYPE-III-A TIBIAL FRACTURE ASSOCIATED WITH SIMULTANEOUS ANTERIOR CRUCIATE LIGAMENT AVULSION FROM THE FEMORAL ORIGIN SO AMERICAN JOURNAL OF SPORTS MEDICINE LA English DT Article RP UHORCHAK, JM (reprint author), KELLER ARMY COMMUNITY HOSP,ORTHOPAED SERV,BLDG 900,W POINT,NY 10996, USA. NR 0 TC 5 Z9 5 U1 0 U2 0 PU AMER ORTHOPAEDIC SOC SPORT MED PI WALTHAM PA 230 CALVARY STREET, WALTHAM, MA 02154 SN 0363-5465 J9 AM J SPORT MED JI Am. J. Sports Med. PD SEP-OCT PY 1993 VL 21 IS 5 BP 758 EP 761 DI 10.1177/036354659302100525 PG 4 WC Orthopedics; Sport Sciences SC Orthopedics; Sport Sciences GA LY341 UT WOS:A1993LY34100024 PM 8238724 ER PT J AU GROGL, M DAUGIRDA, JL HOOVER, DL MAGILL, AJ BERMAN, JD AF GROGL, M DAUGIRDA, JL HOOVER, DL MAGILL, AJ BERMAN, JD TI SURVIVABILITY AND INFECTIVITY OF VISCEROTROPIC LEISHMANIA-TROPICA FROM OPERATION DESERT-STORM PARTICIPANTS IN HUMAN BLOOD PRODUCTS MAINTAINED UNDER BLOOD-BANK CONDITIONS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID VISCERAL LEISHMANIASIS; UNITED-STATES; ENDEMIC AREA; DISEASE; DONOVANI; BRAZIL AB To assess the potential for leishmaniasis being transmitted through blood transfusion, we studied the survival of Leishmania in blood products under blood bank storage, conditions. We report that L. tropica- or L. donovani-contaminated transfusable blood products are a risk to the blood supply for at least 25 days postdonation under blood bank general conditions. The blood components that have been implicated are whole blood, packed red blood cells, platelet concentrate, and frozen-deglycerolized red blood cells, but not, as would be expected, fresh frozen plasma. Blood units containing four infected monocytes per milliliter of blood with a mean of three amastigotes per monocyte contain viable parasites for 15 days under blood bank storage conditions. Furthermore, animal studies showed the presence of parasites in the blood of cutaneously infected animals and the possibility of transmitting the disease to healthy experimental animals by blood transfusion from infected animal donors. Three of three BALB/C mice showed metastasis to the lower extremities and face after they received 0.25 ml of blood from a CPDA-1 bag seeded with 1.5 x 10(5) amastigotes per ml of blood kept under blood bank conditions for 30 days. This proves that Leishmania not only survives blood banking procedures and storage conditions but that the parasite retains its infectivity. The results of this study and the recent demonstration of L. tropica-infected monocytes in the blood of a patient returning from Southwest Asia suggests that transfusion-associated leishmaniasis can occur. C1 WALTER REED ARMY INST RES,DIV COMMUNICABLE DIS & IMMUNOL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT PATHOL,WASHINGTON,DC 20307. RP GROGL, M (reprint author), WALTER REED ARMY INST RES,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307, USA. NR 27 TC 51 Z9 51 U1 0 U2 3 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD SEP PY 1993 VL 49 IS 3 BP 308 EP 315 PG 8 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA LY612 UT WOS:A1993LY61200004 PM 8372954 ER PT J AU OFULLA, AVO OKOYE, VCN KHAN, B GITHURE, JI ROBERTS, CR JOHNSON, AJ MARTIN, SK AF OFULLA, AVO OKOYE, VCN KHAN, B GITHURE, JI ROBERTS, CR JOHNSON, AJ MARTIN, SK TI CULTIVATION OF PLASMODIUM-FALCIPARUM PARASITES IN A SERUM-FREE MEDIUM SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID CULTURE; REQUIREMENTS; LIPOPROTEINS; GROWTH AB The elimination of serum from Plasmodium falciparum culture media could decrease costs, enhance procurement, and improve the feasibility of large-scale production of parasite material. We provide a semi-defined, serum-free formulation, of commercially available constituents that supports P. falciparum parasite growth at rates comparable with those obtained with serum-supplemented media. The medium is composed of RPMI 1640 to which HEPES, extra glucose, bicarbonate, and hypoxanthine have been added. Bovine albumin and serum-derived, lipids-cholesterol-rich mixture are then used in place of serum. C1 WALTER REED ARMY INST RES,DEPT HEMATOL,WASHINGTON,DC 20307. KENYA GOVT MED RES CTR,CLIN RES CTR,NAIROBI,KENYA. WALTER REED ARMY INST RES,USA MED RES UNIT KENYA,WASHINGTON,DC 20307. RP OFULLA, AVO (reprint author), KENYA GOVT MED RES CTR,BIOMED SCI RES CTR,NAIROBI,KENYA. NR 17 TC 32 Z9 32 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD SEP PY 1993 VL 49 IS 3 BP 335 EP 340 PG 6 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA LY612 UT WOS:A1993LY61200008 PM 8396859 ER PT J AU KREUTZER, RD GROGL, M NEVA, FA FRYAUFF, DJ MAGILL, AJ ALEMANMUNOZ, MM AF KREUTZER, RD GROGL, M NEVA, FA FRYAUFF, DJ MAGILL, AJ ALEMANMUNOZ, MM TI IDENTIFICATION AND GENETIC COMPARISON OF LEISHMANIAL PARASITES CAUSING VISCEROTROPIC AND CUTANEOUS DISEASE IN SOLDIERS RETURNING FROM OPERATION DESERT-STORM SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID CULTIVATION; HEALTH; MEDIA AB Six Leishmania major and seven L. tropica parasites were isolated and identified from participants in Operation Desert Shield/Storm. A complete enzyme analysis (21 enzymes) revealed that there was enzyme polymorphism among the isolates of each species group. Any one Desert Storm L. major isolate could differ from any other for 1-3 enzymes, and any L. tropica isolate could differ from any one other for up to eight enzymes. Enzyme polymorphism data from other L. major and L. tropica isolates from Africa and the Middle East region were obtained and combined with the Desert Storm data to produce population enzyme polymorphism estimates. Results from these population data indicated that L. major parasites could be expected to differ from each other for as many as eight enzymes and still be L. major and similarly, L. tropica isolates could differ for as many as 14 enzymes. These expected isolate variation extremes have not been observed among the isolates studied. All L. major and most L. tropica isolates were from patients who, as expected, presented with cutaneous disease, but the Desert Storm and two Kenyan patients infected with L. tropica presented with a viscerotropic disease, the symptoms of which are unlike those of classic visceral leishmaniasis. Such unrecognized presentation for these L. tropica-infected patients indicates that both parasite and patient can play critical roles in disease manifestations. The Desert Storm isolates are, as indicated, either L. major or L. tropica. C1 WALTER REED ARMY INST RES,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307. NIAID,PARASIT DIS LAB,BETHESDA,MD 20892. USN,RES UNIT 3,CAIRO,EGYPT. WALTER REED ARMY MED CTR,DEPT MED,INFECT DIS SERV,WASHINGTON,DC 20307. UNIV PANAMA,FAC MED,CTR INVEST ENFERMEDADES,DEPT MICROBIOL PARASITOL,PANAMA CITY,PANAMA. RP KREUTZER, RD (reprint author), YOUNGSTOWN STATE UNIV,DEPT BIOL,YOUNGSTOWN,OH 44555, USA. NR 13 TC 41 Z9 43 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD SEP PY 1993 VL 49 IS 3 BP 357 EP 363 PG 7 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA LY612 UT WOS:A1993LY61200011 PM 8372957 ER PT J AU GRUNER, E AF GRUNER, E TI FICTION-2000 - CYBERPUNK AND THE FUTURE OF NARRATIVE - SLUSSER,G, SHIPPEY,T SO AMERICAN LITERATURE LA English DT Book Review RP GRUNER, E (reprint author), US MIL ACAD,W POINT,NY 10996, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU DUKE UNIV PRESS PI DURHAM PA BOX 90660, DURHAM, NC 27708-0660 SN 0002-9831 J9 AM LIT JI Am. Lit. PD SEP PY 1993 VL 65 IS 3 BP 594 EP 595 DI 10.2307/2927411 PG 2 WC Literature, American SC Literature GA LU519 UT WOS:A1993LU51900025 ER PT J AU DILLARD, TA AF DILLARD, TA TI ESTIMATING MAXIMUM VENTILATION - INCLUSION OF MAXIMUM INSPIRATORY AND EXPIRATORY AIR-FLOW VARIABLES SO AMERICAN REVIEW OF RESPIRATORY DISEASE LA English DT Letter ID EXERCISE RP DILLARD, TA (reprint author), WALTER REED ARMY MED CTR,PULM FUNCT LAB,WASHINGTON,DC 20307, USA. NR 4 TC 1 Z9 1 U1 0 U2 0 PU AMER LUNG ASSOC PI NEW YORK PA 1740 BROADWAY, NEW YORK, NY 10019 SN 0003-0805 J9 AM REV RESPIR DIS JI Am. Rev. Respir. Dis. PD SEP PY 1993 VL 148 IS 3 BP 819 EP 819 PG 1 WC Respiratory System SC Respiratory System GA LW465 UT WOS:A1993LW46500043 PM 8368656 ER PT J AU GUZZI, LM MILLS, LM GREENMAN, P AF GUZZI, LM MILLS, LM GREENMAN, P TI RHABDOMYOLYSIS, ACUTE-RENAL-FAILURE, AND THE EXAGGERATED LITHOTOMY POSITION SO ANESTHESIA AND ANALGESIA LA English DT Note ID SURGERY; COMPLICATION RP GUZZI, LM (reprint author), WALTER REED ARMY MED CTR,DEPT ANESTHESIA,ANESTHESIA & OPERAT SERV,WASHINGTON,DC 22207, USA. NR 16 TC 24 Z9 25 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0003-2999 J9 ANESTH ANALG JI Anesth. Analg. PD SEP PY 1993 VL 77 IS 3 BP 635 EP 637 PG 3 WC Anesthesiology SC Anesthesiology GA LW216 UT WOS:A1993LW21600036 PM 8368567 ER PT J AU CHRONISTER, T CARTER, BL VANDECAR, T KNAPE, KG AF CHRONISTER, T CARTER, BL VANDECAR, T KNAPE, KG TI DOSE-EFFECT OF INTRATHECAL NARCOTICS ON MATERNAL BLOOD-PRESSURE SO ANESTHESIOLOGY LA English DT Meeting Abstract C1 BROOKE ARMY MED CTR,DEPT ANESTHESIOL,SAN ANTONIO,TX 78234. UTHSC,SAN ANTONIO,TX. NR 1 TC 3 Z9 3 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0003-3022 J9 ANESTHESIOLOGY JI Anesthesiology PD SEP PY 1993 VL 79 IS 3A SU S BP A1001 EP A1001 PG 1 WC Anesthesiology SC Anesthesiology GA LY108 UT WOS:A1993LY10800997 ER PT J AU FONTANA, JL WELBORN, L MONGAN, P MULDOON, S AF FONTANA, JL WELBORN, L MONGAN, P MULDOON, S TI 1ST STUDIES IN PROFOUND NORMOVOLEMIC HEMODILUTION IN MAN - OXYGEN-CONSUMPTION AND CARDIAC DATA IN 5 CHILDREN SO ANESTHESIOLOGY LA English DT Meeting Abstract C1 USUHS,DEPT ANESTHESIOL,WASHINGTON,DC 20010. CHILDRENS NATL MED CTR,DEPT ANESTHESIOL,WASHINGTON,DC 20010. BROOKE ARMY MED CTR,DEPT ANESTHESIOL,WASHINGTON,DC 20010. WALTER REED ARMY MED CTR,DEPT ANESTHESIOL,WASHINGTON,DC 20307. NR 2 TC 3 Z9 3 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0003-3022 J9 ANESTHESIOLOGY JI Anesthesiology PD SEP PY 1993 VL 79 IS 3A SU S BP A163 EP A163 PG 1 WC Anesthesiology SC Anesthesiology GA LY108 UT WOS:A1993LY10800163 ER PT J AU KARAN, SM LOJESKI, EW BOEDEKER, BH HAYNES, DH MULDOON, SM AF KARAN, SM LOJESKI, EW BOEDEKER, BH HAYNES, DH MULDOON, SM TI LECITHIN-COATED DANTROLENE SODIUM MICROCRYSTALS ARE EFFECTIVE IN THE TREATMENT OF MALIGNANT HYPERTHERMIA IN SUSCEPTIBLE SWINE SO ANESTHESIOLOGY LA English DT Meeting Abstract C1 UNIFORMED SERV UNIV HLTH SCI,DEPT ANESTHESIOL,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 2 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0003-3022 J9 ANESTHESIOLOGY JI Anesthesiology PD SEP PY 1993 VL 79 IS 3A SU S BP A437 EP A437 PG 1 WC Anesthesiology SC Anesthesiology GA LY108 UT WOS:A1993LY10800437 ER PT J AU LOJESKI, EW KARAN, SM BOEDEKER, BH FREAS, W HAYNES, DH AF LOJESKI, EW KARAN, SM BOEDEKER, BH FREAS, W HAYNES, DH TI LECITHIN-COATED DANTROLENE SODIUM MICROCRYSTALS VS DANTROLENE SODIUM - DOSE-RESPONSE TO MUSCULAR TWITCH IN SWINE SO ANESTHESIOLOGY LA English DT Meeting Abstract C1 UNIFORMED SERV UNIV HLTH SCI,DEPT ANESTHESIOL,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 4 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0003-3022 J9 ANESTHESIOLOGY JI Anesthesiology PD SEP PY 1993 VL 79 IS 3A SU S BP A438 EP A438 PG 1 WC Anesthesiology SC Anesthesiology GA LY108 UT WOS:A1993LY10800438 ER PT J AU SAYSON, SC MONGAN, PD AF SAYSON, SC MONGAN, PD TI PREDICTING INTUBATING CONDITIONS WITH MIVACURIUM - A COMPARISON OF NEUROMUSCULAR BLOCKADE MONITORING AT THE ADDUCTOR POLLICIS AND THE ORBICULARIS OCULI SO ANESTHESIOLOGY LA English DT Meeting Abstract C1 BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234. NR 4 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0003-3022 J9 ANESTHESIOLOGY JI Anesthesiology PD SEP PY 1993 VL 79 IS 3A SU S BP A18 EP A18 PG 1 WC Anesthesiology SC Anesthesiology GA LY108 UT WOS:A1993LY10800018 ER PT J AU STOLTZFUS, DP RIES, MA WATSON, CB AF STOLTZFUS, DP RIES, MA WATSON, CB TI CRITICAL CARE MEDICINE FELLOWSHIP - A SURVEY OF ACCM PROGRAM DIRECTORS SO ANESTHESIOLOGY LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0003-3022 J9 ANESTHESIOLOGY JI Anesthesiology PD SEP PY 1993 VL 79 IS 3A SU S BP A312 EP A312 PG 1 WC Anesthesiology SC Anesthesiology GA LY108 UT WOS:A1993LY10800312 ER PT J AU CRAIG, TJ DAVIS, W AF CRAIG, TJ DAVIS, W TI HEPATITIS ASSOCIATED WITH HIGH-DOSE INTRAVENOUS GAMMA-GLOBULIN SO ANNALS OF ALLERGY LA English DT Letter ID IMMUNOGLOBULINS C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. RP CRAIG, TJ (reprint author), CHARLESTON NAVAL HOSP,CHARLESTON,SC 29408, USA. NR 5 TC 3 Z9 3 U1 0 U2 0 PU AMER COLL ALLERGY ASTHMA IMMUNOLOGY PI ARLINGTON HTS PA 85 WEST ALGONQUIN RD SUITE 550, ARLINGTON HTS, IL 60005 SN 0003-4738 J9 ANN ALLERGY JI Ann. Allergy PD SEP PY 1993 VL 71 IS 3 BP 276 EP 276 PG 1 WC Allergy SC Allergy GA LY508 UT WOS:A1993LY50800014 PM 8373001 ER PT J AU HATCH, RT DAVIS, WS ENGLER, RJM AF HATCH, RT DAVIS, WS ENGLER, RJM TI SELECTING PATIENTS FOR INSECT VENOM IMMUNOTHERAPY SO ANNALS OF INTERNAL MEDICINE LA English DT Letter RP HATCH, RT (reprint author), WALTER REED ARMY MED CTR,WASHINGTON,DC 20307, USA. NR 5 TC 0 Z9 0 U1 0 U2 0 PU AMER COLL PHYSICIANS PI PHILADELPHIA PA INDEPENDENCE MALL WEST 6TH AND RACE ST, PHILADELPHIA, PA 19106-1572 SN 0003-4819 J9 ANN INTERN MED JI Ann. Intern. Med. PD SEP 1 PY 1993 VL 119 IS 5 BP 438 EP 438 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA LZ476 UT WOS:A1993LZ47600027 PM 8338305 ER PT J AU HILBURN, RB BOOKSTAVER, D WHITLOCK, WL AF HILBURN, RB BOOKSTAVER, D WHITLOCK, WL TI ANGIOTENSIN-CONVERTING ENZYME-INHIBITOR HEPATOTOXICITY - FURTHER INSIGHTS - COMMENT SO ANNALS OF PHARMACOTHERAPY LA English DT Letter ID HEPATITIS; CAPTOPRIL C1 DWIGHT D EISENHOWER ARMY MED CTR,CLIN PHARM SECT,FT GORDON,GA 30905. RP HILBURN, RB (reprint author), DWIGHT D EISENHOWER ARMY MED CTR,DEPT INTERNAL MED,FT GORDON,GA 30905, USA. NR 4 TC 5 Z9 5 U1 0 U2 0 PU HARVEY WHITNEY BOOKS CO PI CINCINNATI PA PO BOX 42696, CINCINNATI, OH 45242 SN 1060-0280 J9 ANN PHARMACOTHER JI Ann. Pharmacother. PD SEP PY 1993 VL 27 IS 9 BP 1142 EP 1142 PG 1 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA LZ349 UT WOS:A1993LZ34900029 PM 8219456 ER PT J AU CIOFFI, WG DELEMOS, RA COALSON, JJ GERSTMANN, DA PRUITT, BA AF CIOFFI, WG DELEMOS, RA COALSON, JJ GERSTMANN, DA PRUITT, BA TI DECREASED PULMONARY DAMAGE IN PRIMATES WITH INHALATION INJURY TREATED WITH HIGH-FREQUENCY VENTILATION SO ANNALS OF SURGERY LA English DT Article; Proceedings Paper CT 113TH ANNUAL SCIENTIFIC SESSION OF THE AMERICAN-SURGICAL-ASSOC CY APR 01-03, 1993 CL BALTIMORE, MD SP AMER SURG ASSOC ID RESPIRATORY-DISTRESS SYNDROME; HYALINE-MEMBRANE DISEASE; HIGH AIRWAY PRESSURE; LUNG INJURY; PERCUSSIVE VENTILATION; MECHANICAL VENTILATION; BABOONS; FAILURE; RABBITS; VOLUME AB Objective This study compared two forms of high-frequency ventilation (HFV) with conventional volume ventilation (CON) in a primate model of inhalation injury to determine whether ventilatory mode was a determinant of pulmonary damage. Summary Background Data The authors previously reported that the prophylactic use of high-frequency flow interruption in patients with bronchoscopically diagnosed inhalation injury requiring mechanical ventilatory support resulted in a significant decrement in mortality. They hypothesized that a reduction in ventilatory mode induced pulmonary damage was in part responsible for their clinical results. Methods Fifteen adult baboons were randomized to one of three ventilatory modes (CON, high-frequency flow interruption [HFFI], or high-frequency oscillatory ventilation [HFO]) after moderate smoke injury. Ventilatory support was tailored to the same physiologic endpoints. After 7 days, the animals were killed and pulmonary pathologic changes were scored and compared. Repetitive physiologic and biochemical data were compared using analysis of variance for repeated measures. Results Physiologic endpoints were achieved in CON and HFFI, but not in HFO. Hemodynamic variables did not diff er between CON and HFFI. The barotrauma index was greater in CON compared to HFFI (p < 0.05), despite similar PO2, FlO2, AA gradient, and PCO2. Animals treated with HFFI had significantly less parenchymal damage than those treated with CON (p = 0.03) or HFO (p = 0.0008). Conclusions The prophylactic use of HFFI led to a significant decrement in ventilatory mode induced pulmonary damage and offers an explanation for the decreased mortality in inhalation injury patients treated with HFFI. C1 SW RES INST,SAN ANTONIO,TX 78284. UNIV TEXAS,HLTH SCI CTR,DEPT PATHOL,SAN ANTONIO,TX 78284. RP CIOFFI, WG (reprint author), USA,INST SURG RES,FT SAM HOUSTON,TX 78234, USA. NR 23 TC 33 Z9 33 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0003-4932 J9 ANN SURG JI Ann. Surg. PD SEP PY 1993 VL 218 IS 3 BP 328 EP 337 DI 10.1097/00000658-199309000-00012 PG 10 WC Surgery SC Surgery GA LW602 UT WOS:A1993LW60200012 PM 8373275 ER PT J AU CHENG, TC HARVEY, SP STROUP, AN AF CHENG, TC HARVEY, SP STROUP, AN TI PURIFICATION AND PROPERTIES OF A HIGHLY-ACTIVE ORGANOPHOSPHORUS ACID ANHYDROLASE FROM ALTEROMONAS-UNDINA SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY LA English DT Note ID ENZYME AB A highly active organophosphorus acid anhydrolase from Alteromonas undina was purified to homogeneity and found to be composed of a single polypeptide chain with a molecular weight of 53,000. With diisopropylfluorophosphate as a substrate, the purified enzyme has a specific activity of approximately 575 mumol/min/mg of protein. The enzyme has optimum activity at pH 8.0 and 55-degrees-C and is stimulated by sulfhydryl reducing agents and manganese. It is capable of rapidly hydrolyzing a wide range of nerve agents and several chromogenic phosphinates. RP CHENG, TC (reprint author), USA,CHEM & BIOL DEF AGCY,EDGEWOOD RES DEV & ENGN CTR,ABERDEEN PROVING GROUND,MD 21010, USA. NR 10 TC 65 Z9 71 U1 4 U2 4 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0099-2240 J9 APPL ENVIRON MICROB JI Appl. Environ. Microbiol. PD SEP PY 1993 VL 59 IS 9 BP 3138 EP 3140 PG 3 WC Biotechnology & Applied Microbiology; Microbiology SC Biotechnology & Applied Microbiology; Microbiology GA LW040 UT WOS:A1993LW04000058 PM 16349054 ER PT J AU ADOMIAN, G MEYERS, R AF ADOMIAN, G MEYERS, R TI NONLINEAR TRANSPORT IN MOVING FLUIDS SO APPLIED MATHEMATICS LETTERS LA English DT Article ID ADOMIAN METHOD; CONVERGENCE; EQUATIONS AB The time-dependent spread of contaminants in moving fluids is normally studied by computer-intensive discretized procedures which have some disadvantages. Application of the decomposition method allows a continuous, convenient, accurate procedure which works and extends to nonlinear and stochastic partial differential equations as well. C1 USA,RES LAB,WHITE SANDS MISSILE RANGE,NM 88002. RP ADOMIAN, G (reprint author), GEN ANALYT CORP,155 CLYDE RD,ATHENS,GA 30605, USA. NR 9 TC 8 Z9 8 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0893-9659 J9 APPL MATH LETT JI Appl. Math. Lett. PD SEP PY 1993 VL 6 IS 5 BP 35 EP 38 DI 10.1016/0893-9659(93)90096-6 PG 4 WC Mathematics, Applied SC Mathematics GA LV302 UT WOS:A1993LV30200008 ER PT J AU DUNN, CL JAMES, WD AF DUNN, CL JAMES, WD TI THE ROLE OF MAGNETIC-RESONANCE-IMAGING IN THE DIAGNOSTIC EVALUATION OF DERMATOMYOSITIS SO ARCHIVES OF DERMATOLOGY LA English DT Article RP DUNN, CL (reprint author), WALTER REED ARMY MED CTR,WASHINGTON,DC 20307, USA. NR 8 TC 11 Z9 11 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0003-987X J9 ARCH DERMATOL JI Arch. Dermatol. PD SEP PY 1993 VL 129 IS 9 BP 1104 EP 1106 DI 10.1001/archderm.129.9.1104 PG 3 WC Dermatology SC Dermatology GA LW373 UT WOS:A1993LW37300003 PM 8363394 ER PT J AU BATTAFARANO, N BATTAFARANO, D ENZENAUER, R LARSEN, L DYER, P MUEHLBAUER, S HOYT, A LIMA, J GOODMAN, D LIEBERMAN, M AF BATTAFARANO, N BATTAFARANO, D ENZENAUER, R LARSEN, L DYER, P MUEHLBAUER, S HOYT, A LIMA, J GOODMAN, D LIEBERMAN, M TI ANTIGEN-SPECIFIC ANTIBODY-RESPONSES IN LUPUS PATIENTS FOLLOWING IMMUNIZATION SO ARTHRITIS AND RHEUMATISM LA English DT Meeting Abstract C1 FITZSIMONS ARMY MED CTR,AURORA,CO 80045. BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0004-3591 J9 ARTHRITIS RHEUM JI Arthritis Rheum. PD SEP PY 1993 VL 36 IS 9 SU S BP S187 EP S187 PG 1 WC Rheumatology SC Rheumatology GA MB816 UT WOS:A1993MB81600877 ER PT J AU THEOCHARIS, S SFIKAKIS, P LIPNICK, RN KLIPPLE, GL TSOKOS, GC AF THEOCHARIS, S SFIKAKIS, P LIPNICK, RN KLIPPLE, GL TSOKOS, GC TI ISOLATION AND FUNCTIONAL-CHARACTERIZATION OF IN-VIVO HPRT-MUTATED T-CELL CLONES FROM PATIENTS WITH SYSTEMIC LUPUS-ERYTHEMATOSUS (SLE) SO ARTHRITIS AND RHEUMATISM LA English DT Meeting Abstract C1 USUHS,DEPT MED,BETHESDA,MD. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0004-3591 J9 ARTHRITIS RHEUM JI Arthritis Rheum. PD SEP PY 1993 VL 36 IS 9 SU S BP S71 EP S71 PG 1 WC Rheumatology SC Rheumatology GA MB816 UT WOS:A1993MB81600197 ER PT J AU TSOKOS, GC OGLESBY, R THEOCHARIS, S SFIKAKIS, PP BARAF, H VIA, CS AF TSOKOS, GC OGLESBY, R THEOCHARIS, S SFIKAKIS, PP BARAF, H VIA, CS TI DEFECTIVE IN-VITRO RESPONSE TO RECALL ANTIGENS IN PATIENTS WITH SYSTEMIC LUPUS-ERYTHEMATOSUS (SLE) IS CORRECTED IN THE PRESENCE OF FUNCTIONAL B7/BB1 ANTIGEN SO ARTHRITIS AND RHEUMATISM LA English DT Meeting Abstract C1 USUHS,DEPT MED,BETHESDA,MD. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. UNIV MARYLAND,BALTIMORE,MD 21201. NR 0 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0004-3591 J9 ARTHRITIS RHEUM JI Arthritis Rheum. PD SEP PY 1993 VL 36 IS 9 SU S BP S238 EP S238 PG 1 WC Rheumatology SC Rheumatology GA MB816 UT WOS:A1993MB81601176 ER PT J AU VASSILOPOULOS, D ZURIER, RB ROSSETTI, RG TSOKOS, GC AF VASSILOPOULOS, D ZURIER, RB ROSSETTI, RG TSOKOS, GC TI EFFECTS OF UNSATURATED FATTY-ACIDS ON ANTI-CD3-MEDIATED CYTOSOLIC-FREE CALCIUM ([CA2+]I) INCREASE IN HUMAN T-LYMPHOCYTES SO ARTHRITIS AND RHEUMATISM LA English DT Meeting Abstract C1 USUHS,DEPT MED,BETHESDA,MD. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. UNIV MASSACHUSETTS,MED CTR,WORCESTER,MA 01655. NR 0 TC 2 Z9 2 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0004-3591 J9 ARTHRITIS RHEUM JI Arthritis Rheum. PD SEP PY 1993 VL 36 IS 9 SU S BP S113 EP S113 PG 1 WC Rheumatology SC Rheumatology GA MB816 UT WOS:A1993MB81600440 ER PT J AU MILLER, JC SHARKEY, TJ GRAHAM, GA MCCAULEY, ME AF MILLER, JC SHARKEY, TJ GRAHAM, GA MCCAULEY, ME TI AUTONOMIC PHYSIOLOGICAL DATA ASSOCIATED WITH SIMULATOR DISCOMFORT SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article ID MOTION SICKNESS; SPECTRAL-ANALYSIS; SINUS ARRHYTHMIA AB A physiological monitoring capability was developed for the Army's Crew Station Research and Development Facility (CSRDF), a research simulator for advanced rotorcraft. Preliminary physiological data are reported from studies of simulator-induced sickness. Our objective was to demonstrate sensitivity of physiological measures relative to self-reports of simulator sickness severity. The data suggested that heart period, tachygastria, and skin conductance level were more sensitive to simulator sickness than were vagal tone and normal myoelectrical gastric activity. C1 MONTERY TECHNOL INC, 1143 G EXECUT CIRCLE, CARY, NC 27511 USA. USA, NASA, AMES RES CTR, R & D BRANCH, CREW STN, MOFFETT FIELD, CA USA. NR 23 TC 13 Z9 13 U1 1 U2 1 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA SN 0095-6562 EI 1943-4448 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD SEP PY 1993 VL 64 IS 9 BP 813 EP 819 PG 7 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA LW050 UT WOS:A1993LW05000005 PM 8216142 ER PT J AU CROWLEY, JS GEYER, SL AF CROWLEY, JS GEYER, SL TI HELICOPTER ROTOR BLADE INJURY - A PERSISTENT SAFETY HAZARD IN THE UNITED-STATES-ARMY SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Note AB Rotor blade injuries are an inherent hazard of helicopter operations. To determine the recent incidence of rotor blade injuries in the U.S. Army, a review of accident records (1972-91) was conducted. Crash-related injuries were not included. During the study period, there were 24 blade strike injuries (12 involving the main rotor), 11 (46%) of which were fatal. Comparison with previous reports indicates a lower rotor blade injury rate in the last decade than in any previous period. The head was injured most frequently (65%), followed by the chest (17%) and abdomen (7%). Protective helmets helped to reduce injury in several instances. Flight crew comprised 49% of the victims, passengers 29%, ground crew 14%, and bystanders 8%. Helicopter crews must maintain situational awareness when around turning blades-professional training alone does not guarantee protection from rotor blade injury. RP CROWLEY, JS (reprint author), USA,AEROMED RES LAB,CREW LIFE SUPPORT BRANCH,POB 577,FT RUCKER,AL 36362, USA. NR 6 TC 2 Z9 2 U1 0 U2 0 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD SEP PY 1993 VL 64 IS 9 BP 854 EP 858 PG 5 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA LW050 UT WOS:A1993LW05000012 PM 8216149 ER PT J AU POTEGAL, M HUHMAN, K MOORE, T MEYERHOFF, J AF POTEGAL, M HUHMAN, K MOORE, T MEYERHOFF, J TI CONDITIONED DEFEAT IN THE SYRIAN GOLDEN-HAMSTER (MESOCRICETUS-AURATUS) SO BEHAVIORAL AND NEURAL BIOLOGY LA English DT Article ID COLONY INTRUDERS; SOCIAL-CONFLICT; RATS; CONTROLLABILITY; BEHAVIOR; BRAIN; MICE C1 WALTER REED ARMY INST RES,DEPT MED NEUROSCI,DIV NEUROPSYCHIAT,WASHINGTON,DC 20307. NR 30 TC 79 Z9 79 U1 1 U2 4 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0163-1047 J9 BEHAV NEURAL BIOL JI Behav. Neural Biol. PD SEP PY 1993 VL 60 IS 2 BP 93 EP 102 DI 10.1016/0163-1047(93)90159-F PG 10 WC Behavioral Sciences; Neurosciences; Psychology SC Behavioral Sciences; Neurosciences & Neurology; Psychology GA LV320 UT WOS:A1993LV32000002 PM 8117243 ER PT J AU CORSO, S VUKELJA, SJ WIENER, D BAKER, WJ AF CORSO, S VUKELJA, SJ WIENER, D BAKER, WJ TI DIFFUSE ALVEOLAR HEMORRHAGE FOLLOWING AUTOLOGOUS BONE-MARROW INFUSION SO BONE MARROW TRANSPLANTATION LA English DT Note ID TRANSPLANT RECIPIENTS; TOXICITY AB Autologous BMT performed in a 57-year-old woman with relapsed large cell lymphoma was complicated bv two consecutive episodes of diffuse alveolar hemorrhage (DAH). The second episode occurred immediately after infusion of autologous BM. DAH is an increasingly recognized complication of autologous BMT and carries a high mortality. It is characterized by dyspnea, cough, bilateral pulmonary infiltrates and progressively bloodier aliquots of bronchoalveolar lavage fluid. The pathogenesis is probably multifactorial involving an initial insult to lung endothelium with inflammatory cells serving as the mediators of subsequent injury. The rapid development of DAH following marrow infusion strongly implicates DMSO as a potential cause in our patient. C1 BROOKE ARMY MED CTR,DEPT ANAT PATHOL,FT SAM HOUSTON,TX 78234. RP CORSO, S (reprint author), BROOKE ARMY MED CTR,DEPT HEMATOL ONCOL,DIV HEMATOL ONCOL,FT SAM HOUSTON,TX 78234, USA. NR 15 TC 18 Z9 19 U1 0 U2 0 PU STOCKTON PRESS PI BASINGSTOKE PA HOUNDMILLS, BASINGSTOKE, HAMPSHIRE, ENGLAND RG21 6XS SN 0268-3369 J9 BONE MARROW TRANSPL JI Bone Marrow Transplant. PD SEP PY 1993 VL 12 IS 3 BP 301 EP 303 PG 3 WC Biophysics; Oncology; Hematology; Immunology; Transplantation SC Biophysics; Oncology; Hematology; Immunology; Transplantation GA LX825 UT WOS:A1993LX82500020 PM 8241990 ER PT J AU GOMELLA, LG MCGINNIS, DE LATTIME, EC BUTLER, K BALTISH, M THOMPSON, I MARSHALL, ME AF GOMELLA, LG MCGINNIS, DE LATTIME, EC BUTLER, K BALTISH, M THOMPSON, I MARSHALL, ME TI TREATMENT OF TRANSITIONAL-CELL CARCINOMA OF THE BLADDER WITH INTRAVESICAL INTERLEUKIN-2 - A PILOT-STUDY SO CANCER BIOTHERAPY LA English DT Article DE INTERLEUKIN-2; BLADDER CANCER ID BACILLUS-CALMETTE-GUERIN; RECOMBINANT INTERLEUKIN-2; ADVANCED CANCER; THERAPY; IMMUNOTHERAPY; INTERFERON; INFUSION; GAMMA AB Human recombinant interleukin-2 (rIL-2) administered systemically can mediate the regression of solid tumors in some patients. IL-2 has been detected in the bladder effluent from, patients treated with intravesical BCG for transitional cell carcinoma of the bladder (TCC), suggesting that IL-2 may be an effector molecule in the mechanism of action of BCG. The purpose of the pilot study was to determine the response rate, duration of response and toxicity of rIL-2 (Cetus) administered intravesically to previously untreated patients and patients who had failed prior intravesical therapy with other agents. Fourteen patients with biopsy proven transitional cell carcinoma (13 Stage TIS/Ta/T1, 1 Stage T2) were treated with 8 weekly instillations of 12X10(6) IU of rIL-2. An index lesion was followed with cystoscopy, biopsy and cytology at three months, with identical follow up every three months thereafter if a response was noted in the index lesion at the first evaluation. There were 3 complete responses (duration of response measured from start of treatment to date of progression) of 9+, 3, 9 months; one patient with TIS, and 2 patients with Ta disease. There were 11 non-responders for an overall response rate of 21%. One patient with extensive CIS had a dramatic partial response and was converted to a complete response with a second 8-week course of rIL-2. All of the complete responders had failed prior intravesical therapy with standard agents. Toxicity from rIL-2 given intravesically was minimal. One patient reported malaise for 24 hours after each treatment and two patients developed asymptomatic lower UTIs. Chemical cystitis was not reported by any patIent. Intravesical rIL-2 did not produce any organ dysfunction toxicity as measured by routine peripheral blood tests. Because rIL-2 has some activity against established TCC of the bladder and has minimal toxicity, it should be tested against BCG in patIenTs whose TCC has been resected fully. C1 UNIV ALABAMA,DIV MED ONCOL,BIRMINGHAM,AL 35294. BROOKE ARMY MED CTR,DEPT SURG,DIV UROL,SAN ANTONIO,TX. THOMAS JEFFERSON UNIV,JEFFERSON MED COLL,DIV MED ONCOL,PHILADELPHIA,PA 19107. RP GOMELLA, LG (reprint author), THOMAS JEFFERSON UNIV,JEFFERSON MED COLL,DEPT UROL,1025 WALNUT ST,PHILADELPHIA,PA 19107, USA. NR 23 TC 10 Z9 10 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 1062-8401 J9 CANCER BIOTHERAPY JI Cancer Biother. PD FAL PY 1993 VL 8 IS 3 BP 223 EP 227 DI 10.1089/cbr.1993.8.223 PG 5 WC Oncology SC Oncology GA ME837 UT WOS:A1993ME83700005 PM 7804362 ER PT J AU CARDELLO, AV AF CARDELLO, AV TI CROSS-CULTURAL SENSORY TESTING - A CHANGING TIDE SO CEREAL FOODS WORLD LA English DT Article RP CARDELLO, AV (reprint author), USA,CTR RES DEV & ENGN,NATICK,MA 01760, USA. NR 0 TC 11 Z9 11 U1 2 U2 2 PU AMER ASSOC CEREAL CHEMISTS PI ST PAUL PA 3340 PILOT KNOB RD, ST PAUL, MN 55121-2097 SN 0146-6283 J9 CEREAL FOOD WORLD JI Cereal Foods World PD SEP PY 1993 VL 38 IS 9 BP 699 EP 701 PG 3 WC Food Science & Technology SC Food Science & Technology GA MA081 UT WOS:A1993MA08100007 ER PT J AU WASSEF, NM ALVING, CR AF WASSEF, NM ALVING, CR TI COMPLEMENT-DEPENDENT PHAGOCYTOSIS OF LIPOSOMES SO CHEMISTRY AND PHYSICS OF LIPIDS LA English DT Article DE LIPOSOMES; COMPLEMENT; PHAGOCYTOSIS; OPSONIZATION; STEALTH LIPIDS; NEGATIVE CHARGE ID SPHINGOMYELIN-CONTAINING LIPOSOMES; NATURALLY-OCCURRING ANTIBODIES; LABILE BINDING-SITE; RABBIT ANTIBODIES; IMMUNE DAMAGE; MACROPHAGES; CHOLESTEROL; CIRCULATION; PHOSPHATIDYLINOSITOL; AUTOANTIBODIES AB In this article we describe an in vitro model for complement-dependent phagocytosis of liposomes. We have previously reported that complement-opsonized liposomes are avidly ingested by murine peritoneal or bone marrow-derived cultured macrophages. However, when the liposomes contained certain lipids, including phosphatidylinositol, ganglioside G(M1), and sulfogalactosyl ceramide, that have been identified as causing prolonged circulation time in vivo, complement-dependent phagocytosis of the liposomes was greatly suppressed. We identify certain additional factors associated with suppressed complement-dependent phagocytosis, including, liposomal negative charge and liposomal prostaglandin E2 or thromboxane B2. Possible mechanisms responsible for supression of complement dependent phagocytosis are suggested. We propose that suppression of complement-dependent phagocytosis could be a contributing factor in the promotion of increased circulation time of 'stealth' liposomes and that complement opsonization probably plays a role in vivo in removing liposomes from the circulation. RP WASSEF, NM (reprint author), WALTER REED ARMY INST RES,DEPT MEMBRANE BIOCHEM,WASHINGTON,DC 20307, USA. NR 50 TC 32 Z9 34 U1 0 U2 2 PU ELSEVIER SCI IRELAND LTD PI CLARE PA CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE, IRELAND SN 0009-3084 J9 CHEM PHYS LIPIDS JI Chem. Phys. Lipids PD SEP PY 1993 VL 64 IS 1-3 BP 239 EP 248 DI 10.1016/0009-3084(93)90068-E PG 10 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA MA217 UT WOS:A1993MA21700017 PM 8242836 ER PT J AU CROCE, F BROWN, SD GREENBAUM, SG SLANE, SM SALOMON, M AF CROCE, F BROWN, SD GREENBAUM, SG SLANE, SM SALOMON, M TI LI-7 NMR AND IONIC-CONDUCTIVITY STUDIES OF GEL ELECTROLYTES BASED ON POLY(ACRYLONITRILE) SO CHEMISTRY OF MATERIALS LA English DT Article ID STATE AB Composite gel electrolytes prepared from mixtures of poly(acrylonitrile) (PAN), ethylene carbonate (EC), propylene carbonate (PC), and LiClO4 or LiAsF6 have been investigated by complex impedance, differential scanning calorimetry (DSC), and Li-7 nuclear magnetic resonance (NMR) spectroscopy. The ionic conductivity of a gel containing LiAsF6 reaches 10(-2) S/cm at 60-degrees-C. Although the conductivity of the gels approach that found in EC/PC liquid electrolytes, NMR line width, and spin-lattice relaxation time (T1) measurements indicate that even short-range ionic mobility is impeded by the presence of the PAN. As in the case of amorphous polyether-salt polymer electrolytes, the onset of Li-7 motional line narrowing in the gels is strongly correlated with the DSC-determined glass transition temperature. C1 CUNY HUNTER COLL,DEPT PHYS,NEW YORK,NY 10021. USA,EPSD,RES LAB,FT MONMOUTH,NJ 07703. UNIV ROMA LA SAPIENZA,DEPT CHEM,I-00185 ROME,ITALY. RI Croce, Fausto/J-8193-2012 NR 16 TC 111 Z9 113 U1 2 U2 20 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0897-4756 J9 CHEM MATER JI Chem. Mat. PD SEP PY 1993 VL 5 IS 9 BP 1268 EP 1272 DI 10.1021/cm00033a014 PG 5 WC Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA LY929 UT WOS:A1993LY92900014 ER PT J AU ROBERTSON, WG AF ROBERTSON, WG TI THIS TERRIBLE SOUND - THE BATTLE-OF-CHICKAMAUGA - COZZENS,P SO CIVIL WAR HISTORY LA English DT Book Review RP ROBERTSON, WG (reprint author), USA COMMAND & GEN STAFF COLL,FT LEAVENWORTH,KS, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU KENT STATE UNIV PRESS PI KENT PA KENT, OH 44242 SN 0009-8078 J9 CIVIL WAR HIST JI Civil War Hist. PD SEP PY 1993 VL 39 IS 3 BP 269 EP 270 PG 2 WC History SC History GA LQ814 UT WOS:A1993LQ81400011 ER PT J AU BALINGIT, AG ANDERSON, JH AF BALINGIT, AG ANDERSON, JH TI CLINICAL-APPLICATION OF CAPTOPRIL RENAL SCINTIGRAPHY IN TAKAYASU ARTERITIS SO CLINICAL NUCLEAR MEDICINE LA English DT Article ID RENOGRAPHY AB Takayasu's disease (pulseless disease) is an uncommon chronic inflammatory disease primarily affecting the medium and large arteries, with a strong predilection for the aortic arch and its branches; hence, it sometimes is referred to as aortic arch syndrome. The etiology is unknown, although a systemic immunologic process seems most likely. About half the reported cases also revealed involvement of the pulmonary and renal arteries. The involvement is more marked in the origin of the vessel than distally. Although it is more common among Orientals, its distribution is worldwide, without racial boundary. A case is presented in which captopril renal scintigraphy and digital subtraction angiography were used to show renal artery stenosis as the cause of the patient's hypertension. RP BALINGIT, AG (reprint author), WALTER REED ARMY MED CTR,DEPT RADIOL,NUCL MED SERV,WASHINGTON,DC 20307, USA. NR 8 TC 2 Z9 2 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0363-9762 J9 CLIN NUCL MED JI Clin. Nucl. Med. PD SEP PY 1993 VL 18 IS 9 BP 742 EP 745 DI 10.1097/00003072-199309000-00002 PG 4 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA LW513 UT WOS:A1993LW51300002 PM 8104750 ER PT J AU HUGHES, SA AF HUGHES, SA TI LABORATORY WAVE REFLECTION ANALYSIS USING CO-LOCATED GAUGES SO COASTAL ENGINEERING LA English DT Article AB Most coastal and ocean engineering laboratories employ techniques that use two or three spatially separated wave gages to estimate reflection of irregular waves in two-dimensional wave flumes. This paper presents a frequency domain method for separating incident and reflected wave spectra from co-located gages (gages located on the same vertical line). The technique is based on linear wave theory, and it can be applied to time series of sea surface elevation and horizontal water velocity collected in a vertical array, or it can be used with horizontal and vertical water velocity time series collected at the same point in the water column. Application of the method is limited to those frequencies showing good coherence between time series signals. Outside the range of good coherence, gross inaccuracies occur. The utility of the co-located gape method is illustrated using water velocity data collected in a wave flume with a laser Doppler velocimeter, and the method is validated for the case of complete reflection by a vertical wall. Side-by-side comparison to the spatially-separated wave gage method of Goda and Suzuki ( 1976) exhibited close agreement for a variety of irregular wave trains being weakly reflected by a mild sloping beach. The co-located gage method is useful in situations where there are spatial variations in the wavelength. such as on a mildly sloping bottom, or in the region close to highly reflective structures where errors arising from spatial variations in characteristic wave parameters would corrupt estimates made using the spatially-separated wave gage method. RP HUGHES, SA (reprint author), USA,ENGINEER WATERWAYS EXPT STN,COASTAL ENGN RES CTR,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 16 TC 27 Z9 27 U1 2 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-3839 J9 COAST ENG JI Coast. Eng. PD SEP PY 1993 VL 20 IS 3-4 BP 223 EP 247 DI 10.1016/0378-3839(93)90003-Q PG 25 WC Engineering, Civil; Engineering, Ocean SC Engineering GA MD118 UT WOS:A1993MD11800003 ER PT J AU SAUSA, RC ANDERSON, WR DAYTON, DC FAUST, CM HOWARD, SL AF SAUSA, RC ANDERSON, WR DAYTON, DC FAUST, CM HOWARD, SL TI DETAILED STRUCTURE STUDY OF A LOW-PRESSURE, STOICHIOMETRIC H2/N2O/AR FLAME SO COMBUSTION AND FLAME LA English DT Article ID NITROUS-OXIDE FLAMES; HIGH-TEMPERATURE PHOTOCHEMISTRY; KINETIC DATA-BASE; SHOCK-TUBE; RATE-CONSTANT; COMBUSTION CHEMISTRY; PREMIXED COMBUSTION; N2O-H2 REACTION; NO; NH AB A combined experimental and detailed chemical modeling study has been performed on a 20 torr, stoichiometric H-2/N2O/Ar burner stabilized flame. Species concentration profiles were measured using molecular beam sampling with mass spectrometric detection and laser-induced fluorescence, while temperature profiles were measured with coated Pt/Pt-Rh(10%) thermocouples. The burned gases of the flame contain about 2 mol.% of NO and H-2, a concentration of approximately ten times more than that of their equilibrium. This formation prevents full energy release of the system within or near the flame zone. Experimental flame profiles of the major species, H-2, N2O, N2, and H2O, as well as the minor species, NO, O2, OH, H, O, and NH, are presented and compared to calculated profiles generated by PREMIX, a one-dimensional premixed laminar flame code. The chemical mechanism used in the flame code was derived from a critical literature review and consists of 38 reactions and 14 species. Rate and sensitivity analyses performed reveal the intricacies of the mechanism as well as reactions important in the modeling of the experimental results. Several key reactions, including N2O + OH = HO2 + N2 and N2O + H = NO + NH, whose rate coefficients have been controversial, are discussed in detail. In addition, the importance of various collision partners in the key initiation step, N2O + M = N2 + O + M, is presented and discussed. RP SAUSA, RC (reprint author), USA,RES LAB,AMSRL WT PC,ABERDEEN PROVING GROUND,MD 21005, USA. NR 83 TC 27 Z9 27 U1 0 U2 3 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0010-2180 J9 COMBUST FLAME JI Combust. Flame PD SEP PY 1993 VL 94 IS 4 BP 407 EP 425 DI 10.1016/0010-2180(93)90123-K PG 19 WC Thermodynamics; Energy & Fuels; Engineering, Multidisciplinary; Engineering, Chemical; Engineering, Mechanical SC Thermodynamics; Energy & Fuels; Engineering GA LU240 UT WOS:A1993LU24000006 ER PT J AU BEHR, M JOHNSON, A KENNEDY, J MITTAL, S TEZDUYAR, T AF BEHR, M JOHNSON, A KENNEDY, J MITTAL, S TEZDUYAR, T TI COMPUTATION OF INCOMPRESSIBLE FLOWS WITH IMPLICIT FINITE-ELEMENT IMPLEMENTATIONS ON THE CONNECTION MACHINE SO COMPUTER METHODS IN APPLIED MECHANICS AND ENGINEERING LA English DT Article ID DATA PARALLEL SUPERCOMPUTER; GRAPHS AB Two implicit finite element formulations for incompressible flows have been implemented on the Connection Machine supercomputers and successfully applied to a set of time-dependent problems. The stabilized space-time formulation for moving boundaries and interfaces, and a new stabilized velocity-pressure-stress formulation are both described, and significant aspects of the implementation of these methods on massively parallel architectures are discussed. Several numerical results for flow problems involving moving as well as fixed cylinders and airfoils are reported. The parallel implementation, taking full advantage of the computational speed of the new generation of supercomputers, is found to be a significant asset in fluid dynamics research. Its current capability to solve large-scale problems, especially when coupled with the potential for growth enjoyed by massively parallel computers, make the implementation a worthwhile enterprise. C1 UNIV MINNESOTA,INST SUPERCOMP,1200 WASHINGTON AVE S,MINNEAPOLIS,MN 55415. THINKING MACHINES CORP,CAMBRIDGE,MA 02142. UNIV MINNESOTA,ARMY HIGH PERFORMANCE COMP RES CTR,DEPT AEROSP ENGN & MECH,MINNEAPOLIS,MN 55415. RI Behr, Marek/H-5401-2011; Tezduyar, Tayfun/F-6134-2012 OI Behr, Marek/0000-0003-4257-8276; Tezduyar, Tayfun/0000-0001-8707-3162 NR 25 TC 50 Z9 50 U1 0 U2 0 PU ELSEVIER SCIENCE SA LAUSANNE PI LAUSANNE 1 PA PO BOX 564, 1001 LAUSANNE 1, SWITZERLAND SN 0045-7825 J9 COMPUT METHOD APPL M JI Comput. Meth. Appl. Mech. Eng. PD SEP PY 1993 VL 108 IS 1-2 BP 99 EP 118 DI 10.1016/0045-7825(93)90155-Q PG 20 WC Engineering, Multidisciplinary; Mathematics, Interdisciplinary Applications; Mechanics SC Engineering; Mathematics; Mechanics GA MB974 UT WOS:A1993MB97400006 ER PT J AU HURSH, SR AF HURSH, SR TI BEHAVIORAL ECONOMICS OF DRUG SELF-ADMINISTRATION - AN INTRODUCTION SO DRUG AND ALCOHOL DEPENDENCE LA English DT Article DE BEHAVIORAL ECONOMICS; DRUG ABUSE; DRUG SELF-ADMINISTRATION; ABUSE LIABILITY; DRUG ABUSE POLICY ID DEMAND; FOOD; REINFORCEMENT; COST AB Behavioral economics provides a set of concepts for the analysis of factors that control the allocation of behavioral resources among available reinforcers. Terms from micro-economics describe new phenomena previously ignored within the traditional context of behavior analysis. This article reviews these concepts as an introduction to the three papers that follow. The primary dependent measure within the behavioral economic framework is the level of consumption of available commodities as determined by the level and distribution of instrumental responding. The demand curve provides a quantitative metric for analyzing consumption under the constraint of unit price. When the reinforcer is a drug, the demand curve can be a useful tool for analyzing the level of motivation to consume the drug, its abuse liability, and for evaluating interventions, such as alternative reinforcers or medications, to reduce the motivation to consume the drug and instrumental responding to obtain it. Behavioral economics also provides a framework for formulating, testing, and refining drug abuse policy through a series of empirical steps that maximize effectiveness and minimize undesirable social consequences. RP HURSH, SR (reprint author), WALTER REED ARMY INST RES,DIV NEUROPSYCHIAT,WASHINGTON,DC 20307, USA. NR 25 TC 54 Z9 54 U1 2 U2 4 PU ELSEVIER SCI IRELAND LTD PI CLARE PA CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE, IRELAND SN 0376-8716 J9 DRUG ALCOHOL DEPEN JI Drug Alcohol Depend. PD SEP PY 1993 VL 33 IS 2 BP 165 EP 172 DI 10.1016/0376-8716(93)90058-X PG 8 WC Substance Abuse; Psychiatry SC Substance Abuse; Psychiatry GA LZ980 UT WOS:A1993LZ98000008 PM 8261881 ER PT J AU FILBERT, MG DOCHTERMAN, LW SMITH, CD FORSTER, JS PHANN, S CANN, FJ AF FILBERT, MG DOCHTERMAN, LW SMITH, CD FORSTER, JS PHANN, S CANN, FJ TI EFFECT OF MANNITOL TREATMENT ON SOMAN-INDUCED BRAIN AND HEART LESIONS IN THE RAT SO DRUG DEVELOPMENT RESEARCH LA English DT Article DE ANTICHOLINESTERASE; SEIZURES; EXCITOTOXICITY; NEUROPATHY; CARDIOMYOPATHY ID EXTRACELLULAR AMINO-ACIDS; INDUCED SEIZURE ACTIVITY; KAINIC ACID; CHEMICAL SYNAPSES; HIPPOCAMPUS; CONVULSIONS; DIAZEPAM AB The effect of intravenous mannitol on soman-induced neuropathology and cardiomyopathy was studied in rats. Soman, an organophosphorus agent, irreversibly inhibits total body acetylcholinesterase and induces a cholinotoxic syndrome in rats which results in the development of seizures, brain damage, and degenerative cardiomyopathy. The severity of the cardiomyopathy parallels the severity of the neuropathology. When mannitol at a dose of 1.5 g/kg was administered at the onset of seizures and followed by a second dose 5 h later, there was a significant increase in 24 h survival. Moreover, the severity of brain lesions was reduced in the piriform cortex, thalamus, amygdala, and the caudate putamen. The same treatment schedule also provided almost complete protection against the concomitant development of degenerative cardiomyopathy. The finding that the mannitol treatments reduced both the severity of the neuropathology and the degenerative cardiomyopathy reinforces the concept of a possible central neurogenic mechanism for the development of the cardiomyopathy. These results suggest that mannitol may be useful to reduce the severity of seizure-related neuropathology and to provide additional protection to other vital organs which may be secondarily susceptible to neurogenically mediated pathologic change, such as the heart in rats which develop cardiomyopathy following soman-induced seizures. (C) 1993 Wiley-Liss, Inc. RP FILBERT, MG (reprint author), USA,MED RES INST CHEM DEF,DIV PATHOPHYSIOL,SGRD,UV,YN,ABERDEEN PROVING GROUND,MD 21010, USA. NR 38 TC 9 Z9 9 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0272-4391 J9 DRUG DEVELOP RES JI Drug Dev. Res. PD SEP PY 1993 VL 30 IS 1 BP 45 EP 53 DI 10.1002/ddr.430300107 PG 9 WC Chemistry, Medicinal; Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA MC920 UT WOS:A1993MC92000006 ER PT J AU WEISS, RB CHRISTIAN, MC AF WEISS, RB CHRISTIAN, MC TI NEW CISPLATIN ANALOGS IN DEVELOPMENT - A REVIEW SO DRUGS LA English DT Review ID BLEOMYCIN COMBINATION CHEMOTHERAPY; SOUTHWEST-ONCOLOGY-GROUP; ADVANCED OVARIAN-CANCER; HUMAN-TUMOR XENOGRAFTS; CARCINOMA CELL-LINES; ENHANCED DNA-REPAIR; PHASE-I; ANTITUMOR-ACTIVITY; PLATINUM COMPLEX; CIS-DIAMMINEDICHLOROPLATINUM AB Cisplatin was discovered to have cytotoxic properties in the 1960s, and by the end of the 1970s it had earned a place as the key ingredient in the systemic treatment of germ cell cancers. Since the early seminal work in the preclinical and clinical development of this drug, several thousand analogues have been synthesised and tested for properties that would enhance the therapeutic index of cisplatin. About 13 of these analogues have been evaluated in clinical trials, but only one (carboplatin) has provided definite advantage over cisplatin and achieved worldwide approval. However, carboplatin has afforded benefit only in reducing some cisplatin toxicities; it has not enlarged the spectrum of platinum-sensitive cancers, nor has it proved active in cisplatin-resistant cancers. The major obstacle to the efficacy of cisplatin or carboplatin is platinum resistance, either innate or acquired. The mechanisms of this resistance have been under intense study, and many of the cisplatin analogues synthesised in the past decade have been designed specifically with the hope of overcoming platinum resistance. The mechanism of the cytotoxic activity of platinum complexes has also been studied intensely. Recently synthesised analogues have been designed to interact with DNA in a manner different from cisplatin and carboplatin, with the desire of finding new structures with a superior or wider spectrum of antitumour efficacy. Most recently water soluble platinum complexes that retain antitumour activity, but that can be effectively absorbed after oral administration, have been synthesised with the goal of improving patient quality of life. Nine platinum analogues are currently in clinical trials around the world (ormaplatin [tetraplatin], oxaliplatin, DWA2114R, enloplatin, lobaplatin, CI-973 [NK-121], 254-S, JM-216 and liposome-entrapped cis-bis-neodecanoato-trans-R,R-1,2-diaminocyclohexane platinum (II) (LNDDP]). Some of these analogues only represent attempts to reduce cisplatin toxicity and/or allow administration without forced hydration and diuresis, which carboplatin already does. Others are 'third generation' complexes shown to have limited or no cross-resistance with cisplatin in preclinical studies. They am being tested clinically with particular attention to this highly desirable property. Some of these complexes will undoubtedly disappear into oblivion as have most of their predecessors. It is hoped that the 1990s will see the development (and worldwide registration) of another platinum complex that represents a step forward in cancer therapy, perhaps one active in cisplatin-refractory cancers and/or capable of being administered orally. C1 UNILEVER FORSCH GESELL MBH,W-2000 HAMBURG 50,GERMANY. NCI,DIV CANC TREATMENT,CANC THERAPY EVALUAT PROGRAM,INVEST DRUG BRANCH,BETHESDA,MD 20892. RP WEISS, RB (reprint author), WALTER REED ARMY MED CTR,MED ONCOL SECT,WASHINGTON,DC 20307, USA. NR 109 TC 296 Z9 300 U1 5 U2 41 PU ADIS INTERNATIONAL LTD PI AUCKLAND PA 41 CENTORIAN DR, PRIVATE BAG 65901, MAIRANGI BAY, AUCKLAND 10, NEW ZEALAND SN 0012-6667 J9 DRUGS JI Drugs PD SEP PY 1993 VL 46 IS 3 BP 360 EP 377 DI 10.2165/00003495-199346030-00003 PG 18 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA MA091 UT WOS:A1993MA09100003 PM 7693428 ER PT J AU LINK, HT WHITE, K KRZYCH, U AF LINK, HT WHITE, K KRZYCH, U TI PLASMODIUM-BERGHEI-SPECIFIC T-CELLS RESPOND TO NON-PROCESSED SPOROZOITES PRESENTED BY B-CELLS SO EUROPEAN JOURNAL OF IMMUNOLOGY LA English DT Article DE P-BERGHEI; CIRCUMSPOROZOITE PROTEIN; T-CELLS; ANTIGEN PROCESSING ID FALCIPARUM CIRCUMSPOROZOITE PROTEIN; ANTIGEN-PRESENTATION; MALARIA SPOROZOITES; VACCINE DEVELOPMENT; ACCESSORY CELLS; ENTEROTOXIN-A; MOLECULES; ANTIBODIES; SUPERANTIGENS; IMMUNIZATION AB The mechanism of malaria protective immunity induced by immunization with radiation-attenuated Plasmodium sporozoites (SPZ) is only partially understood. For example, B and T cell responses specific for the circumsporozoite (CS) protein, a 46 kDa SPZ surface protein, have been characterized; however, events leading to SPZ-specific T cell activation, i. e., processing and presentation of SPZ by antigen-presenting cells have not been investigated. In the present study we describe the in vitro analysis of requirements for accessory cell function in the presentation of SPZ to SPZ-immune T cells. The results establish that SPZ-induced proliferative T cells are reactive to non-processed SPZ presented by activated B cells and, thus, imply that the non-processed form of the SPZ-associated CS protein restricts the induction of the potential CS protein T cell repertoire. C1 WALTER REED ARMY INST RES,DEPT IMMUNOL,WASHINGTON,DC 20307. CATHOLIC UNIV AMER,DEPT BIOL,WASHINGTON,DC 20064. NR 45 TC 17 Z9 17 U1 0 U2 0 PU VCH PUBLISHERS INC PI DEERFIELD BEACH PA 303 NW 12TH AVE, DEERFIELD BEACH, FL 33442-1788 SN 0014-2980 J9 EUR J IMMUNOL JI Eur. J. Immunol. PD SEP PY 1993 VL 23 IS 9 BP 2263 EP 2269 DI 10.1002/eji.1830230932 PG 7 WC Immunology SC Immunology GA LY555 UT WOS:A1993LY55500031 PM 8370405 ER PT J AU OPSAHL, MS MILLER, B KLEIN, TA AF OPSAHL, MS MILLER, B KLEIN, TA TI THE PREDICTIVE VALUE OF HYSTEROSALPINGOGRAPHY FOR TUBAL AND PERITONEAL INFERTILITY FACTORS SO FERTILITY AND STERILITY LA English DT Article DE HYSTEROSALPINGOGRAM; INFERTILITY; FALLOPIAN TUBE DISEASES ID FEMALE INFERTILITY; LAPAROSCOPY; DIAGNOSIS; SALPINGOGRAPHY; OBSTRUCTION; OCCLUSION; PATENCY; SUCCESS AB Objective: To investigate a practical classification system of hysterosalpingogram (HSG) results that accurately identifies patients with severe pelvic disease or a normal pelvis to allow appropriate patient counseling of therapeutic options. Design: Retrospective chart review from university teaching hospital. Hysterosalpingography results were classified as normal, abnormal (bilateral distal tubal obstruction), or suspicious (all others). At surgery, chromopertubation was performed, and pelvic disease was documented. Results: From a total of 756 patients, HSGs were confirmed surgically in 96.6% of normals, 63.1% of suspicious, and 95.7% of abnormal. Associated moderate-severe pelvic disease was found in 16.2% of normals, 53.9% of suspicious, and 81.7% of abnormal. Conclusion: Abnormal HSGs are highly predictive of severe pelvic disease, and counseling of treatment options does not require diagnostic laparoscopy. Patients with suspicious HSGs frequently have normal tubes but also have a significant likelihood of tubal or associated pelvic disease, and they are responsible for the poor predictive value of the HSG. This group of patients requires confirmatory laparoscopy preferably by a physician qualified in pelviscopic surgery. Normal HSGs have a high negative predictive value. Nevertheless, the incidence of associated pelvic disease in the normal HSG group is high enough to warrant diagnostic laparoscopy if nonsurgical treatment is unsuccessful. C1 UNIFORMED SERV UNIV HLTH SCI, BETHESDA, MD 20814 USA. WALTER REED ARMY MED CTR, WASHINGTON, DC 20307 USA. RP OPSAHL, MS (reprint author), NATL NAVAL MED CTR, DEPT OBSTET & GYNECOL, DIV REPROD ENDOCRINOL, BETHESDA, MD 20889 USA. OI Opsahl, Michael/0000-0002-8754-7943 NR 21 TC 27 Z9 29 U1 0 U2 0 PU AMER SOC REPRODUCTIVE MEDICINE PI BIRMINGHAM PA 1209 MONTGOMERY HIGHWAY, BIRMINGHAM, AL 35216-2809 SN 0015-0282 J9 FERTIL STERIL JI Fertil. Steril. PD SEP PY 1993 VL 60 IS 3 BP 444 EP 448 PG 5 WC Obstetrics & Gynecology; Reproductive Biology SC Obstetrics & Gynecology; Reproductive Biology GA LX344 UT WOS:A1993LX34400011 PM 8375524 ER PT J AU ECHEVERRIA, P SETHABUTR, O SERICHANTALERGS, O AF ECHEVERRIA, P SETHABUTR, O SERICHANTALERGS, O TI MODERN DIAGNOSIS (WITH MOLECULAR TESTS) OF ACUTE INFECTIOUS DIARRHEA SO GASTROENTEROLOGY CLINICS OF NORTH AMERICA LA English DT Review ID POLYMERASE CHAIN-REACTION; TOXIGENIC ESCHERICHIA-COLI; LINKED-IMMUNOSORBENT-ASSAY; TOXIN GENE PROBES; SYNTHETIC OLIGONUCLEOTIDE PROBES; THERMOSTABLE DNA-POLYMERASE; DETECT SALMONELLA-TYPHI; PERFRINGENS TYPE-C; GROUP-B ROTAVIRUS; GROUP-A ROTAVIRUS RP ECHEVERRIA, P (reprint author), ARMED FORCES RES INST MED SCI,DEPT BACTERIOL IMMUNOL & MOLEC GENET,315-6 RAJVITHI RD,BANGKOK 10400,THAILAND. NR 167 TC 7 Z9 7 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0889-8553 J9 GASTROENTEROL CLIN N JI Gastroenterol. Clin. North Am. PD SEP PY 1993 VL 22 IS 3 BP 661 EP 682 PG 22 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA LW823 UT WOS:A1993LW82300012 PM 8406735 ER PT J AU HESLER, LS AF HESLER, LS TI NEW RECORDS OF LEAF-FEEDING FOR ADULT DIABROTICA-BARBERI (COLEOPTERA, CHRYSOMELIDAE) SO GREAT LAKES ENTOMOLOGIST LA English DT Article AB The first records of leaf-feeding on Iva xanthifolia (marsh elder) and Helianthus annuus (common-sunflower) by adult Diabrotica barberi are reported. During September 1992, beetles were observed feeding on leaves of these plants, despite the availability of alternate flowering hosts. Beetles confined to clip cages in the laboratory fed readily on leaves of I. xanthifolia and H. annuus but not on those of Solidago missouriensis (goldenrod). RP HESLER, LS (reprint author), USA,CTR AMEDD,FT SAM HOUSTON,TX 78234, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MICH ENTOMOL SOC PI E LANSING PA MICH STATE UNIV DEPT ENTOMOL, E LANSING, MI 48823 SN 0090-0222 J9 GREAT LAKES ENTOMOL JI Gt. Lakes Entomol. PD FAL PY 1993 VL 26 IS 3 BP 241 EP 243 PG 3 WC Entomology SC Entomology GA MM683 UT WOS:A1993MM68300007 ER PT J AU TENERIELLO, M FARLEY, J PARKER, M OCONNOR, D SHAVER, T PARK, R BARNHILL, D AF TENERIELLO, M FARLEY, J PARKER, M OCONNOR, D SHAVER, T PARK, R BARNHILL, D TI MANAGEMENT OF ADVANCED OVARIAN EPITHELIAL CANCER IN THE RENAL-TRANSPLANT PATIENT SO GYNECOLOGIC ONCOLOGY LA English DT Note ID RECIPIENTS C1 WALTER REED ARMY MED CTR,DEPT SURG,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,DEPT OBSTET & GYNECOL,BETHESDA,MD 20814. UNIFORMED SERV UNIV HLTH SCI,DEPT PATHOL,BETHESDA,MD 20814. RP TENERIELLO, M (reprint author), WALTER REED ARMY MED CTR,DEPT OBSTET & GYNECOL,GYNECOL ONCOL SERV,WASHINGTON,DC 20307, USA. NR 14 TC 5 Z9 5 U1 0 U2 0 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0090-8258 J9 GYNECOL ONCOL JI Gynecol. Oncol. PD SEP PY 1993 VL 50 IS 3 BP 374 EP 378 DI 10.1006/gyno.1993.1229 PG 5 WC Oncology; Obstetrics & Gynecology SC Oncology; Obstetrics & Gynecology GA MC190 UT WOS:A1993MC19000021 PM 8406205 ER PT J AU CUOLOCKKNOPP, VG WHITAKER, LA AF CUOLOCKKNOPP, VG WHITAKER, LA TI SPATIAL ABILITY AND LAND NAVIGATION UNDER DEGRADED VISUAL CONDITIONS SO HUMAN FACTORS LA English DT Article AB Land navigation tasks require the use of visual cues. When these cues are degraded by the loss of resolution, navigators suffer varying degrees of performance decrements. We tested the hypothesis that these decrements are less severe for people of high spatial ability than they are for people of low spatial ability. We tested 108 noncommissioned officers on a task that required them to determine if two woodland photographs taken from different directions (N, NE, E ... NW) were of the same location; spatial ability was assessed using the Cognitive Laterality Battery. Spatial ability was related to the ability to do this task. Furthermore, there was a significant interaction between spatial ability and visual resolution on recognition performance. This article discusses the implications of these results for teleoperations and land navigation. C1 UNIV DAYTON, DAYTON, OH 45469 USA. RP CUOLOCKKNOPP, VG (reprint author), USA, RES LAB, VISUAL & AUDITORY PROC BRANCH, AMSRI HR SD, ABERDEEN PROVING GROUND, MD 21005 USA. NR 5 TC 0 Z9 0 U1 0 U2 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA SN 0018-7208 EI 1547-8181 J9 HUM FACTORS JI Hum. Factors PD SEP PY 1993 VL 35 IS 3 BP 511 EP 520 PG 10 WC Behavioral Sciences; Engineering, Industrial; Ergonomics; Psychology, Applied; Psychology SC Behavioral Sciences; Engineering; Psychology GA ME589 UT WOS:A1993ME58900008 ER PT J AU CHOWDHURY, DQ HILL, SC MAZUMDER, M AF CHOWDHURY, DQ HILL, SC MAZUMDER, M TI QUALITY FACTORS AND EFFECTIVE-AVERAGE MODAL GAIN OR LOSS IN INHOMOGENEOUS SPHERICAL RESONATORS - APPLICATION TO 2-PHOTON ABSORPTION SO IEEE JOURNAL OF QUANTUM ELECTRONICS LA English DT Article ID MORPHOLOGY-DEPENDENT RESONANCES; TIME-INDEPENDENT PERTURBATION; STIMULATED RAMAN-SCATTERING; LIQUID DROPLETS; MICRODROPLETS; GENERATION; PARTICLES; EMISSION; SPHERES AB A method is presented for calculating the quality factors (Q's) and the effective-average gain and loss coefficients for the modes of a dielectric sphere which has a spatial perturbation of the imaginary part of the refractive index. The method is applicable to gain calculations in spherical lasers, to spatial hole burning and to stimulated Raman scattering in spheres. A time-independent perturbation method [7] is also used to compute the Q's of the resonances. Results computed using both methods are compared with analytical results for layered spheres. The methods are used to compute the near-resonance backscattering by a sphere having an intensity-dependent (two-photon absorption) loss. C1 NEW MEXICO STATE UNIV,DEPT ELECT & COMP ENGN,LAS CRUCES,NM 88003. YALE UNIV,DEPT PHYS,NEW HAVEN,CT 06520. YALE UNIV,CTR APPL DIAGNOST,NEW HAVEN,CT 06520. USA,ATMOSPHER SCI LAB,WHITE SANDS MISSILE RANGE,NM 88002. NR 25 TC 16 Z9 16 U1 0 U2 2 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9197 J9 IEEE J QUANTUM ELECT JI IEEE J. Quantum Electron. PD SEP PY 1993 VL 29 IS 9 BP 2553 EP 2561 DI 10.1109/3.247714 PG 9 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA MM215 UT WOS:A1993MM21500016 ER PT J AU KAZAKOS, D COOPER, AB AF KAZAKOS, D COOPER, AB TI EXPONENTIAL ERROR-BOUNDS FOR CODING THROUGH NOISY CHANNELS WITH INACCURATELY KNOWN STATISTICS AND FOR GENERALIZED DECISION RULES SO IEEE TRANSACTIONS ON COMMUNICATIONS LA English DT Article AB Generalized decoding decision rules provide added flexibility in a decoding scheme, and some advantages. In a generalized decoding decision rule, the following possibilities are considered: 1) The decoder has the option of not deciding at all, or rejecting all estimates. This is termed an erasure. 2) The decoder has the option of putting out more than one estimate. The resulting output is called a list. Only if the correct codeword is not on the list do we have a list error. Forney developed error bounds in his seminal paper of 1968, in which he used Gallager's ingenious 1965 method of bounding error probabilities. In this paper, we consider another realistic factor, the lack of exact knowledge of the channel statistics. We assume a mismatch between the true channel transition probabilities and the nominal probabilities used in the decoding metric. We develop, then, error bounds under mismatch, for generalized decision rules. We establish, also, conditions under which the error probabilities converge to zero exponentially with the block length, in spite of the presence of mismatch. C1 UNIV DELAWARE,DEPT COMP SCI,NEWARK,DE 19718. UNIV VIRGINIA,DEPT ELECT ENGN & MATH,CHARLOTTESVILLE,VA 22901. UNIV VIRGINIA,DEPT ELECT ENGN,CHARLOTTESVILLE,VA 22901. JOHNS HOPKINS UNIV,DEPT ELECT & COMP ENGN,BALTIMORE,MD 21218. USA,RES LAB,ADV COMP & INFORMAT SCI DIRECTORATE,ABERDEEN PROVING GROUND,MD 21005. NR 9 TC 1 Z9 1 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0090-6778 J9 IEEE T COMMUN JI IEEE Trans. Commun. PD SEP PY 1993 VL 41 IS 9 BP 1329 EP 1334 DI 10.1109/26.237851 PG 6 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA LY090 UT WOS:A1993LY09000012 ER PT J AU JOHNSON, JT KONG, JA SHIN, RT STAELIN, DH ONEILL, K LOHANICK, AW AF JOHNSON, JT KONG, JA SHIN, RT STAELIN, DH ONEILL, K LOHANICK, AW TI 3RD STOKES PARAMETER EMISSION FROM A PERIODIC WATER-SURFACE SO IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING LA English DT Article AB An experiment in which the third Stokes parameter thermal emission from a periodic water surface was measured is documented. This parameter is shown to be related to the direction of periodicity of the periodic surface and to approach brightnesses of up to 30 K at X band for the surface used in the experiment. The surface actually analyzed was a ''two layer'' periodic surface; the theory of thermal emission from such a surface is derived and the theoretical results are found to be in good agreement with the experimental measurements. These results further the idea of using the third Stokes parameter emission as an indicator of wind direction over the ocean. C1 MIT,ELECTR RES LAB,CAMBRIDGE,MA 02139. COLD REGIONS RES & ENGN LAB,HANOVER,NH. RP JOHNSON, JT (reprint author), MIT,DEPT ELECT ENGN & COMP SCI,CAMBRIDGE,MA 02139, USA. NR 10 TC 19 Z9 19 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0196-2892 J9 IEEE T GEOSCI REMOTE JI IEEE Trans. Geosci. Remote Sensing PD SEP PY 1993 VL 31 IS 5 BP 1066 EP 1080 DI 10.1109/36.263778 PG 15 WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote Sensing; Imaging Science & Photographic Technology SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science & Photographic Technology GA MP174 UT WOS:A1993MP17400015 ER PT J AU RACICOT, RL AF RACICOT, RL TI INCREASING MISSION RELIABILITY BY USING OPEN-LOOP CONTROL SO IEEE TRANSACTIONS ON RELIABILITY LA English DT Article DE MISSION RELIABILITY; FEEDBACK SENSOR FAILURE; MODIFIED BANG-BANG CONTROL; OPEN LOOP CONTROL AB Reliability of some 1-degree of freedom servo systems can be increased by providing a degraded mode of operation in the event of feedback sensor failure. Mission reliability is increased because redundancy is introduced. The numerical value of increased reliability is neither estimated nor predicted; rather, a general computer software approach is provided that appreciably increases the reliability. The servo system is comprised of a computer-controlled motor-driven mechanism which repositions a given mass. The servo motor is controlled by real-time computer software/hardware which generates a digital-to-analog voltage proportional to motor force. Feedback from the mechanism provides real-time position & velocity information. Using feedback to determine required motor torques according to some control law leads to closed-loop control. An open-loop controller, on the other hand, requires no feedback information but must rely on-predictions of the entire motion cycle with no updating of the current state. Normally, the mechanical system operates in a closed-loop feedback mode. During normal operation, additional information is continuously gathered on the disturbing forces encountered and their statistical variations from cycle to cycle. Disturbing forces are non-motor generated forces, eg, friction, gravity, and inertial coupling. These forces can be estimated after completion of a closed-loop cycle by analyzing the history of position, velocity, and motor forces. This disturbing-force information is used to design an open-loop controller that can instantaneously take over the repositioning task in the event of feedback sensor malfunction. An ideal and relatively general closed-loop control law that was used in these studies is the modified bang-bang (MBB) controller. There are many other control laws but the MBB controller is amenable to design of the open-loop approach in this paper. The main reason is that the operating cycle of the MBB controller is readily divided into 3 motion sections: acceleration, constant velocity, and deceleration. Disturbing forces can be readily estimated in each section. The measured mean & standard deviation (StdDev) of the disturbing forces are used to design a conservative open-loop cycle. The cycle is conservative in that the target position for open loop is chosen to be less than the actual desired target position by an amount that yields a specified small probability of exceeding the target at some specified confidence level during any given random cycle. The goal is to prevent excessive overshoot or inadvertent crashing of the mechanism into its end stops whenever open-loop control is used. At the end of the open-loop cycle, the mass should be short of its final goal. The total open-loop cycle is then finished using a constant or cyclic motor force or other technique depending on the specific application. The key to success of this open-loop procedure is the theoretical derivation of the mean & StdDev of final position as a function of the statistics of the measured disturbing forces. A simple equation permits real-time application of the results. These techniques were successfully applied to the loading cycle of a large-caliber tank ammunition autoloader. After operating the autoloader for many normal closed-loop cycles, the feedback loss was simulated and then these open-loop techniques were used. The primary disturbing force encountered during these successful trials was high random friction. RP RACICOT, RL (reprint author), USA,CTR ARMAMENT RDE,CTR CLOSE COMBAT ARMAMENTS,BENET LABS,WATERVLIET,NY 12189, USA. NR 9 TC 1 Z9 1 U1 1 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9529 J9 IEEE T RELIAB JI IEEE Trans. Reliab. PD SEP PY 1993 VL 42 IS 3 BP 384 EP 392 DI 10.1109/24.257821 PG 9 WC Computer Science, Hardware & Architecture; Computer Science, Software Engineering; Engineering, Electrical & Electronic SC Computer Science; Engineering GA ME868 UT WOS:A1993ME86800008 ER PT J AU MIZAN, M STURZEBECHER, D HIGGINS, T PAOLELLA, A AF MIZAN, M STURZEBECHER, D HIGGINS, T PAOLELLA, A TI AN X-BAND, HIGH-POWER DIELECTRIC RESONATOR OSCILLATOR FOR FUTURE MILITARY SYSTEMS SO IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL LA English DT Article AB A 9.0-GHz dielectric resonator oscillator (DRO), generating a CW output power of 2.5 W at room temperature, has been designed and fabricated by using a high power GaAs MESFET and a dielectric resonator (DR) in a parallel feedback configuration. The oscillator exhibited a frequency stability of better than 130 ppm, without any temperature compensation, over the range -50-degrees-C to +50-degrees-C. The output power varied from +35 dBm (3.2 W) at -50-degrees-C, to +33 dBm (2 W) at +50-degrees-C. The single-sideband phase noise levels were measured and found to be -105 and -135 dBc/Hz, at 10- and 100-kHz carrier offset frequencies, respectively. The oscillator output was then fed into a single-stage high power MESFET amplifier, resulting in a total RF power output of 6.5 W. The overall dc to RF conversion efficiency of the 6.5-W unit was approximately 15.3%. C1 USA,RES LAB,E&PS DIRECTORATE,FT MONMOUTH,NJ 07703. RP MIZAN, M (reprint author), USA,ELECTR TECHNOL & DEVICES LAB,FT MONMOUTH,NJ 07703, USA. NR 10 TC 5 Z9 6 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0885-3010 J9 IEEE T ULTRASON FERR JI IEEE Trans. Ultrason. Ferroelectr. Freq. Control PD SEP PY 1993 VL 40 IS 5 BP 483 EP 487 DI 10.1109/58.238099 PG 5 WC Acoustics; Engineering, Electrical & Electronic SC Acoustics; Engineering GA MA444 UT WOS:A1993MA44400007 PM 18263210 ER PT J AU VIG, JR AF VIG, JR TI MILITARY APPLICATIONS OF HIGH-ACCURACY FREQUENCY STANDARDS AND CLOCKS SO IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL LA English DT Article ID TIME TRANSFER AB Frequency control and timing devices are essential components in modern military electronics systems. This paper reviews the applications of these devices, and the manner in which the stability and accuracy of these devices impact the performance of military communication, navigation, surveillance, electronic warfare, missile guidance, and identification-friend-or-foe (IFF) systems. RP VIG, JR (reprint author), USA,RES LAB,FT MONMOUTH,NJ 07703, USA. OI Vig, John/0000-0002-2378-0113 NR 30 TC 43 Z9 43 U1 0 U2 5 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0885-3010 J9 IEEE T ULTRASON FERR JI IEEE Trans. Ultrason. Ferroelectr. Freq. Control PD SEP PY 1993 VL 40 IS 5 BP 522 EP 527 DI 10.1109/58.238104 PG 6 WC Acoustics; Engineering, Electrical & Electronic SC Acoustics; Engineering GA MA444 UT WOS:A1993MA44400012 PM 18263215 ER PT J AU KOSINSKI, JA BALLATO, A AF KOSINSKI, JA BALLATO, A TI DESIGNING FOR LOW ACCELERATION SENSITIVITY SO IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL LA English DT Article ID CONTOURED QUARTZ RESONATORS; RECTANGULAR SUPPORTS; MASS AB Acceleration sensitivity remains one of the most difficult problems faced by the piezoelectric devices industry. After a decade of intensive research, many questions still remain as to how to achieve reproducibly low acceleration sensitivity (10(-10)/g) even in the laboratory. In this paper we discuss recent advances in acceleration sensitivity measurement and modeling with an emphasis on what these advances indicate in terms of designing for low acceleration sensitivity. We separate the design suggestions into two parts, namely, the crystal resonator as a mechanical vibrator and the crystal oscillator as an electronic circuit. The resonator section includes such topics as symmetry considerations, metallization, mounting, etc., in both bulk acoustic wave-(BAW) and surface acoustic wave (SAW) devices, while the oscillator circuit section discusses the equivalent circuit modeling of crystal resonators and other loop components. RP KOSINSKI, JA (reprint author), USA,RES LAB,FT MONMOUTH,NJ 07703, USA. NR 31 TC 11 Z9 11 U1 0 U2 2 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0885-3010 J9 IEEE T ULTRASON FERR JI IEEE Trans. Ultrason. Ferroelectr. Freq. Control PD SEP PY 1993 VL 40 IS 5 BP 532 EP 537 DI 10.1109/58.238106 PG 6 WC Acoustics; Engineering, Electrical & Electronic SC Acoustics; Engineering GA MA444 UT WOS:A1993MA44400014 PM 18263217 ER PT J AU TAYLOR, DN TROFA, AC SADOFF, J CHU, CY BRYLA, D SHILOACH, J COHEN, D ASHKENAZI, S LERMAN, Y EGAN, W SCHNEERSON, R ROBBINS, JB AF TAYLOR, DN TROFA, AC SADOFF, J CHU, CY BRYLA, D SHILOACH, J COHEN, D ASHKENAZI, S LERMAN, Y EGAN, W SCHNEERSON, R ROBBINS, JB TI SYNTHESIS, CHARACTERIZATION, AND CLINICAL-EVALUATION OF CONJUGATE VACCINES COMPOSED OF THE O-SPECIFIC POLYSACCHARIDES OF SHIGELLA-DYSENTERIAE TYPE-1, SHIGELLA-FLEXNERI TYPE-2A, AND SHIGELLA-SONNEI (PLESIOMONAS-SHIGELLOIDES) BOUND TO BACTERIAL TOXOIDS SO INFECTION AND IMMUNITY LA English DT Article ID SERUM ANTIBODIES; ESCHERICHIA-COLI; NATURAL IMMUNITY; LIPOPOLYSACCHARIDE; PROTECTION; IMMUNIZATION; ANTIGEN; INFECTIONS; VIRULENCE; CHILDREN AB The theoretic basis for developing conjugate vaccines, to induce immunoglobulin G (IgG) lipopolysaccharide (LPS) antibodies for the prevention of shigellosis, has been described (J. B. Robbins, C.-Y. Chu, and R. Schneerson, Clin. Infect. Dis. 15:346-361, 1992). The O-specific polysaccharides (O-SPs) of Shigella dysenteriae type 1, S. flexneri type 2a, and S. sonnei were covalently bound to carrier proteins. Alone, the O-SPs were not immunogenic in mice. Conjugates of these O-SPs, injected into young outbred mice subcutaneously as saline solutions containing 2.5 mug of saccharide, elicited serum IgG and IgM antibodies with booster responses; adsorption onto alum enhanced their immunogenicity. Injection of 25 mug of these conjugates into adult volunteers elicited mild local reactions only. Each conjugate induced a significant rise of the geometric mean serum IgG, IgM, and IgA LPS antibody levels. A second injection 6 weeks later did not elicit booster responses, and adsorption of the conjugates onto alum did not enhance their immunogenicity. Conjugate-induced levels of IgA, but not IgG or IgM, declined to preimmunization levels at day 56. The levels of postimmunization antibodies of the three immunoglobulin classes were similar to or higher than those of recruits in the Israel Defense Force following shigellosis caused by S. flexneri type 2a or S. sonnei. These data provide the basis for evaluating these conjugates to prevent shigellosis. C1 US FDA,CTR BIOL EVALUAT & RES,BETHESDA,MD 20852. ISRAEL DEF FORCES,MED CORPS,TEL AVIV,ISRAEL. NICHHD,BIOMETRY & MATH STAT BRANCH,BETHESDA,MD 20892. NICHHD,DEV & MOLEC IMMUN LAB,BETHESDA,MD 20892. NIDDKD,CELLULAR & MOLEC BIOL LAB,BIOTECHNOL UNIT,BETHESDA,MD 20892. RP TAYLOR, DN (reprint author), WALTER REED ARMY INST RES,DIV COMMUNICABLE DIS & IMMUNOL,WASHINGTON,DC 20307, USA. NR 52 TC 109 Z9 115 U1 0 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD SEP PY 1993 VL 61 IS 9 BP 3678 EP 3687 PG 10 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA LU858 UT WOS:A1993LU85800014 PM 8359890 ER PT J AU HUNTER, SEC BROWN, JE OYSTON, PCF SAKURAI, J TITBALL, RW AF HUNTER, SEC BROWN, JE OYSTON, PCF SAKURAI, J TITBALL, RW TI MOLECULAR-GENETIC ANALYSIS OF BETA-TOXIN OF CLOSTRIDIUM-PERFRINGENS REVEALS SEQUENCE HOMOLOGY WITH ALPHA-TOXIN, GAMMA-TOXIN, AND LEUKOCIDIN OF STAPHYLOCOCCUS-AUREUS SO INFECTION AND IMMUNITY LA English DT Article ID NUCLEOTIDE-SEQUENCE; ENTERITIS NECROTICANS; CLONING; PURIFICATION AB Oligonucleotide probes designed on the basis of the N-terminal sequence of Clostridium perfringens beta-toxin were used to isolate the encoding gene (cpb). The nucleotide sequence of cpb was determined, and on the basis of DNA hybridization experiments it was shown that the gene is found only in type B and C strains of C. perfringens. The deduced amino acid sequence of the beta-toxin revealed homology with the alpha-toxin, gamma-toxin, and leukocidin of Staphylococcus aureus. The beta-toxin purified from C. perfringens appeared to exist in monomeric and multimeric forms. Recombinant beta-toxin, produced in Escherichia coli, appeared to be mainly in the multimeric form. C1 CHEM & BIOL DEF ESTAB,SALISBURY SP4 0JQ,WILTS,ENGLAND. USA,MED RES INST INFECT DIS,FT DETRICK,FREDERICK,MD 21702. TOKUSHIMA BUNRI UNIV,FAC PHARMACEUT SCI,TOKUSHIMA 770,JAPAN. NR 37 TC 106 Z9 115 U1 0 U2 3 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD SEP PY 1993 VL 61 IS 9 BP 3958 EP 3965 PG 8 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA LU858 UT WOS:A1993LU85800050 PM 8359918 ER PT J AU SMITH, KJ SKELTON, HG HAWKS, C YEAGER, J WAGNER, KF AF SMITH, KJ SKELTON, HG HAWKS, C YEAGER, J WAGNER, KF TI CONCURRENT HPV-16 INFECTION OF THE NIPPLE AND PERIANAL AREA IN AN HIV-1+ PATIENT SO INTERNATIONAL JOURNAL OF DERMATOLOGY LA English DT Article ID HUMAN PAPILLOMAVIRUS; EPIDERMODYSPLASIA VERRUCIFORMIS; BOWENOID PAPULOSIS; ASSOCIATION; ANTIGENS; WOMEN; MEN AB Background In patients with HIV-1 disease there has been an increasing association with human papilloma virus (HPV) infections in multiple locations as well as an increase in associated tumors. In addition, there has been increased recovery Of Hpv in individuals with decreasing T4 cell counts. Case Report. Recently we have seen an HIV-1+ patient with a cutaneous lesion on the nipple, as well as multiple perianal lesions in which HPV-16 was demonstrated by in-situ hybridization. Although these lesions contained the same subtype Of HPV virus, they had very different clinical and histopathologic morphologies, and this represents the first reported association Of HPV-16 in a nipple lesion. Discussion. Our patient illustrates that in HIV-1 disease, HPV infections may present in more diffuse and atypical locations. In addition, the diffuse staining with the in-situ probe for HIV-16 within the lesions, tends to support the findings of others, that viral recovery increases with the immune suppression induced by HIV-1. C1 ARMED FORCES INST PATHOL,DEPT DERMATOPATHOL,WASHINGTON,DC 20306. HENRY M JACKSON FDN,BETHESDA,MD. WALTER REED ARMY MED CTR,DEPT DERMATOL,WASHINGTON,DC 20307. WALTER REED ARMY INST RES,WASHINGTON,DC 20307. NR 23 TC 4 Z9 4 U1 0 U2 0 PU BLACKWELL SCIENCE LTD PI OXFORD PA OSNEY MEAD, OXFORD, OXON, ENGLAND OX2 0EL SN 0011-9059 J9 INT J DERMATOL JI Int. J. Dermatol. PD SEP PY 1993 VL 32 IS 9 BP 664 EP 667 PG 4 WC Dermatology SC Dermatology GA LV265 UT WOS:A1993LV26500010 PM 8407095 ER PT J AU VOGEL, P SMITH, KJ SKELTON, HG CUOZZO, D WAGNER, KF AF VOGEL, P SMITH, KJ SKELTON, HG CUOZZO, D WAGNER, KF TI VERRUCOUS LESIONS OF HERPES-SIMPLEX IN HIV-1+ PATIENTS SO INTERNATIONAL JOURNAL OF DERMATOLOGY LA English DT Article ID ORAL HAIRY LEUKOPLAKIA; VIRUS; AIDS; INFECTION C1 ARMED FORCES INST PATHOL,DEPT DERMATOPATHOL,WASHINGTON,DC 20306. HENRY M JACKSON FDN,BETHESDA,MD. WALTER REED ARMY MED CTR,DEPT DERMATOL,WASHINGTON,DC 20307. WALTER REED ARMY INST RES,WASHINGTON,DC 20307. NR 12 TC 15 Z9 15 U1 0 U2 0 PU BLACKWELL SCIENCE LTD PI OXFORD PA OSNEY MEAD, OXFORD, OXON, ENGLAND OX2 0EL SN 0011-9059 J9 INT J DERMATOL JI Int. J. Dermatol. PD SEP PY 1993 VL 32 IS 9 BP 680 EP 682 PG 3 WC Dermatology SC Dermatology GA LV265 UT WOS:A1993LV26500015 PM 8407100 ER PT J AU WANG, WG AF WANG, WG TI ALUMINUM-ALLOYS FOR AIRCRAFT APPLICATIONS SO JOM-JOURNAL OF THE MINERALS METALS & MATERIALS SOCIETY LA English DT Editorial Material RP WANG, WG (reprint author), USA,RES LAB,WATERTOWN,MA 02172, USA. NR 0 TC 2 Z9 3 U1 0 U2 0 PU MINERALS METALS MATERIALS SOC PI WARRENDALE PA 420 COMMONWEALTH DR, WARRENDALE, PA 15086 SN 1047-4838 J9 JOM-J MIN MET MAT S JI JOM-J. Miner. Met. Mater. Soc. PD SEP PY 1993 VL 45 IS 9 BP 16 EP 18 PG 3 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering; Mineralogy; Mining & Mineral Processing SC Materials Science; Metallurgy & Metallurgical Engineering; Mineralogy; Mining & Mineral Processing GA LW185 UT WOS:A1993LW18500003 ER PT J AU LUCEY, DR VANCOTT, TC LOOMIS, LD BETHKE, FR HENDRIX, CW MELCHER, GP REDFIELD, RR BIRX, DL AF LUCEY, DR VANCOTT, TC LOOMIS, LD BETHKE, FR HENDRIX, CW MELCHER, GP REDFIELD, RR BIRX, DL TI MEASUREMENT OF CEREBROSPINAL-FLUID ANTIBODY TO THE HIV-1 PRINCIPAL NEUTRALIZING DETERMINANT (V3 LOOP) SO JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY LA English DT Article DE CEREBROSPINAL FLUID; INTRATHECAL ANTIBODY; V3 LOOP; HIV GP120 ID HUMAN-IMMUNODEFICIENCY-VIRUS; CENTRAL-NERVOUS-SYSTEM; AIDS-RELATED COMPLEX; BLOOD-BRAIN-BARRIER; STATES AIR-FORCE; HTLV-III; MATERNAL ANTIBODIES; VERTICAL TRANSMISSION; INTRATHECAL SYNTHESIS; PEPTIDE-SYNTHESIS AB Antibody to the human immunodeficiency virus (HIV)-1 principal neutralizing determinant (V3 loop) was measured by peptide enzyme-linked immunosorbent assay (ELISA) in cerebrospinal fluid (CSF) and paired serum samples of 21 HIV-seropositive patients. These patients had normal neurologic examinations and were without neurologic symptoms. Peptide ELISA demonstrated intrathecal antibody synthesis against the V3 loop of HIV(MN), the V3 loop of HIV(NY5), the V3 loop of HIV(LAI), and the entire recombinant HIV-1MN gp120 in 21 of 21, 10 of 21, one of 21, and 12 of 21 patients, respectively. Biospecific interaction analysis (BIAcore), which requires only small amounts of CSF, was also used to detect anti-V3 CSF antibody. Fine mapping of linear epitopes within the V3 region was successful in three of five patients by Geysen PIN (PEPSCAN) ELISA and discordance between epitope specificity of CSF and serum antibody was found. While detection of CSF antibody against the V3 loop of HIV(MN) by peptide ELISA has been recently reported, we add to this finding using the peptide ELISA. PEPSCAN and BIAcore methodologies as well as measuring intrathecal antibody synthesis against V3 loops from HIV strains. Application of these techniques to future studies of anti-V3 antibody in CSF from persons receiving anti-HIV-1 immunizations may provide insight into the immunoregulation of the virus in the nervous system. C1 WALTER REED ARMY INST RES,DEPT RETROVIRAL RES,WASHINGTON,DC 20307. WILFORD HALL USAF MED CTR,DEPT MED,SAN ANTONIO,TX. RI Hendrix, Craig/G-4182-2014 OI Hendrix, Craig/0000-0002-5696-8665 NR 57 TC 9 Z9 9 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 1077-9450 J9 J ACQ IMMUN DEF SYND JI J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. PD SEP PY 1993 VL 6 IS 9 BP 994 EP 1001 PG 8 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA MC828 UT WOS:A1993MC82800004 PM 7688046 ER PT J AU LIPNICK, RN HUNG, W PANDIAN, MR AF LIPNICK, RN HUNG, W PANDIAN, MR TI NEUROSARCOIDOSIS PRESENTING AS SECONDARY AMENORRHEA IN A TEENAGER SO JOURNAL OF ADOLESCENT HEALTH LA English DT Note ID SARCOIDOSIS AB Sarcoidosis is a systemic inflammatory disease of unknown etiology characterized by non-caseating epithelioid cell granulomata. The lungs and reticulo-endothelial system are typically involved, and virtually any organ system may be affected (1,2). Sarcoidosis involving the central nervous system is relatively uncommon, estimated to occur in approximately 5% of patients with sarcoidosis in the United States, while the incidence throughout the world may be as high as 15% (3,4). Hypothalamic dysfunction is the most common manifestation of central nervous system parenchymatous disease in neurosarcoidosis. Polyuria and polydipsia are the most frequently occurring symptoms in patients with sarcoidosis who have dysfunction of the pituitary and hypothalamus (5,6). We describe a patient with secondary amenorrhea resulting from neurosarcoidosis involving the pituitary and hypothalamus. C1 NICHOLS INST,SAN JUAN CAPISTRANO,CA. GEORGETOWN UNIV,SCH MED,DEPT PEDIAT,WASHINGTON,DC 20057. RP LIPNICK, RN (reprint author), WALTER REED ARMY MED CTR,DEPT CLIN INVEST,BLDG 2,ROOM 6316,WASHINGTON,DC 20307, USA. NR 17 TC 12 Z9 12 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 1054-139X J9 J ADOLESCENT HEALTH JI J. Adolesc. Health PD SEP PY 1993 VL 14 IS 6 BP 464 EP 467 DI 10.1016/1054-139X(93)90119-A PG 4 WC Psychology, Developmental; Public, Environmental & Occupational Health; Pediatrics SC Psychology; Public, Environmental & Occupational Health; Pediatrics GA MA343 UT WOS:A1993MA34300010 PM 8241204 ER PT J AU YONG, YK STEWART, JT BALLATO, A AF YONG, YK STEWART, JT BALLATO, A TI A LAMINATED PLATE-THEORY FOR HIGH-FREQUENCY, PIEZOELECTRIC THIN-FILM RESONATORS SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID VIBRATIONS AB A high frequency, piezoelectric, laminated plate theory is developed and presented for the purpose of modeling and analyzing piezoelectric thin-film resonators and filters. The laminated plate equations are extensions of anisotropic composite plate theories to include piezoelectric effects and capabilities for modeling harmonic overtones of thickness-shear vibrations. Two-dimensional equations of motion for piezoelectric laminates were deduced from the three-dimensional equations of linear piezoelectricity by expanding the mechanical displacements and electric potential in a series of trigonometric function, and obtaining stress resultants by integrating through the plate thickness. Relations for handling the mechanical and electrical effects of platings on the top and bottom surfaces of the laminate are derived. A new matrix method of correcting the cutoff frequencies is presented. This matrix method could also be used to efficiently correct the cutoff frequencies of any nth order plate laminate theories which employ Mindlin's form of polynomial expansion of mechanical displacements and electric potential through the plate thickness. The first order laminated plate theory with correction factors for cutoff frequencies and slope of the flexural branch at large frequencies was applied to a 2-layer, zinc oxide-silicon strip, and a 3-layer, zinc oxide-zinc oxide-silicon strip. Open circuit, dispersion relations were generated for a range of volume fractions and compared to the exact dispersion relations. Both the 2-layer and 3-layer strip show similar qualitative comparison: The present theory compares fairly well with the exact dispersion relation for real wave numbers and nonpropagating (imaginary) wave numbers which are smaller than 0.5i. The extensional branch, and thickness-shear branches begin to deviate from the exact solution when the nondimensionalized frequency is greater than one. Consequently, to maintain accuracy of solutions when using the present first order laminated plate theory, one should limit the calculation of resonant, nondimensionalized frequencies to less than 1.1. Results for the frequency spectrum in the vicinity of the open circuit, fundamental thickness-shear frequency, and modes shapes were presented for the 2-layer strip with fixed edges, and a volume fraction of silicon equal to 0.2. The technically important fundamental thickness-shear mode is found to have the shear component strongly coupled with extensional component. C1 USA,ETDL,FT MONMOUTH,NJ 07703. RP YONG, YK (reprint author), RUTGER STATE UNIV,DEPT CIVIL ENVIRONM ENGN,POB 909,PISCATAWAY,NJ 08855, USA. NR 23 TC 18 Z9 19 U1 0 U2 5 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD SEP 1 PY 1993 VL 74 IS 5 BP 3028 EP 3046 DI 10.1063/1.354619 PG 19 WC Physics, Applied SC Physics GA LV391 UT WOS:A1993LV39100005 ER PT J AU FLEMISH, JR PFEFFER, RL AF FLEMISH, JR PFEFFER, RL TI LOW HYDROGEN CONTENT SILICON-NITRIDE FILMS FROM ELECTRON-CYCLOTRON-RESONANCE PLASMAS SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID CHEMICAL VAPOR-DEPOSITION; RADIATION-DAMAGE; LOW-TEMPERATURE AB The material and electrical properties of SiN(x):H films deposited using a 2% SiH4/N2 mixture with additional N2 in an electron cyclotron resonance reactor have been evaluated. Deposition rate, refractive index, and stoichiometry have been determined using ellipsometry, Rutherford backscattering spectrometry, and infrared spectroscopy. Current-voltage and dielectric breakdown characteristics have been measured on metal-insulator-silicon structures. Stoichiometric material with a hydrogen content of 1.5 at. % is created using a ratio of SiH4/N2=0.003, P=2 mTorr, T=250-degrees-C, and power=650 W. Hydrogen levels are reduced by using lower ratios of SiH4/N2, lower total pressure, or higher microwave power. Higher total pressure results in significantly enhanced deposition rates, but with greatly increased H and 0 content. The low-field resistivity of these films is largely independent of the process parameters over the range investigated. The dielectric breakdown strength is significantly greater in films deposited at higher temperature, but is somewhat degraded in films deposited at lower ratios of SiH4/N2, despite the higher density and lower hydrogen content of these films. RP FLEMISH, JR (reprint author), USA,RES LAB,ELECTR & POWER SOURCES DIRECTORATE,FT MONMOUTH,NJ 07703, USA. NR 17 TC 33 Z9 33 U1 0 U2 4 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD SEP 1 PY 1993 VL 74 IS 5 BP 3277 EP 3281 DI 10.1063/1.355318 PG 5 WC Physics, Applied SC Physics GA LV391 UT WOS:A1993LV39100044 ER PT J AU SOKOLIK, I YANG, Z KARASZ, FE MORTON, DC AF SOKOLIK, I YANG, Z KARASZ, FE MORTON, DC TI BLUE-LIGHT ELECTROLUMINESCENCE FROM P-PHENYLENE VINYLENE-BASED COPOLYMERS SO JOURNAL OF APPLIED PHYSICS LA English DT Note ID TRANSPORT LAYER; EMITTING-DIODES; POLYMERS; DEVICES; CONFINEMENT; EMISSION; FILMS; CHAIN AB Electroluminescence (EL) in the blue region of the spectrum with a maximum at 465 nm was observed from polymer films sandwiched between indium-tin-oxide and Al electrodes. The specially designed soluble multiblock copolymers used consisted of chromophoric units that have uniform conjugation length and are spaced with polymethylene units of various lengths. EL originates from the radiative decay of the chromophore singlet excitation created as a result of the recombination of injected charge carriers. C1 USA,LAB COMMAND,ELECTR & POWER SOURCES DIRECTORY,FT MONMOUTH,NJ 07703. RP SOKOLIK, I (reprint author), UNIV MASSACHUSETTS,DEPT POLYMER SCI & ENGN,AMHERST,MA 01003, USA. NR 28 TC 131 Z9 134 U1 0 U2 3 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD SEP 1 PY 1993 VL 74 IS 5 BP 3584 EP 3586 DI 10.1063/1.354539 PG 3 WC Physics, Applied SC Physics GA LV391 UT WOS:A1993LV39100093 ER PT J AU REEVES, JT MCCULLOUGH, RE MOORE, LG CYMERMAN, A WEIL, JV AF REEVES, JT MCCULLOUGH, RE MOORE, LG CYMERMAN, A WEIL, JV TI SEA-LEVEL PCO2 RELATES TO VENTILATORY ACCLIMATIZATION AT 4,300-M SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE ALTITUDE; HYPOXIC VENTILATORY RESPONSE; HUMAN ID OBSTRUCTIVE PULMONARY-DISEASE; OXYGEN-TRANSPORT; FAMILIAL FACTORS; CHRONIC HYPOXIA; LUNG-DISEASE; HYPOVENTILATION; ALTITUDE; EXERCISE; EVEREST AB There is considerable variation among individuals in the extent of, and the time required for, ventilatory acclimatization to altitude. Factors related to this variation are unclear. The present study tested whether interindividual variation in preascent ventilation or magnitude of hypoxic ventilatory response related to ventilatory acclimatization to altitude. Measurements in 37 healthy resting male subjects at sea level indicated a wide range (34-48 Torr) of end-tidal PCO2 values. When these subjects were taken to Pikes Peak, CO (4,300 m, barometric pressure 462 mmHg), the end-tidal PCO2 values measured on arrival and repeatedly over 19 days were correlated with the sea-level end-tidal PCO2. At 4,300 m, subjects with high end-tidal PCO2 had low values of arterial oxygen saturation (Sa(O2)). Also, sea-level end-tidal PCO2 related to Sa(O2) after 19 days at 4,300 m. Twenty-six of the subjects had measurements of isocapnic hypoxic ventilatory response (HVR) at sea level. The end-tidal PCO2 values on arrival and after 19 days residence at 4,300 m were inversely related to the sea-level HVR values. Thus both the PCO2 and the HVR as measured at sea level related to the extent of subsequent ventilatory acclimatization (decrease in end-tidal PCO2) and the level of oxygenation at altitude. The finding in our cohort of subjects that sea-level end-tidal PCO2 was inversely related to HVR raised the possibility that among individuals the magnitude of the hypoxic drive to breathe influenced the amount of ventilation at all altitudes, including sea level. C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. RP REEVES, JT (reprint author), UNIV COLORADO,HLTH SCI CTR,CARDIOVASC PULM RES LAB,B-133,4200 E 9TH AVE,DENVER,CO 80262, USA. FU NHLBI NIH HHS [HL-14985] NR 23 TC 55 Z9 55 U1 0 U2 2 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 8750-7587 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD SEP PY 1993 VL 75 IS 3 BP 1117 EP 1122 PG 6 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA LY896 UT WOS:A1993LY89600013 PM 8226519 ER PT J AU ROCK, PB KRAEMER, WJ FULCO, CS TRAD, LA MALCONIAN, MK ROSE, MS YOUNG, PM CYMERMAN, A AF ROCK, PB KRAEMER, WJ FULCO, CS TRAD, LA MALCONIAN, MK ROSE, MS YOUNG, PM CYMERMAN, A TI EFFECTS OF ALTITUDE ACCLIMATIZATION ON FLUID REGULATORY HORMONE RESPONSE TO SUBMAXIMAL EXERCISE SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE HYPOXIA; ATRIAL NATRIURETIC PEPTIDE; RENIN; ALDOSTERONE; ACUTE MOUNTAIN SICKNESS ID ATRIAL-NATRIURETIC-PEPTIDE; ACUTE MOUNTAIN-SICKNESS; CONGESTIVE HEART-FAILURE; OPERATION EVEREST-II; PLASMA-LEVELS; ADRENOCEPTOR BLOCKADE; ALDOSTERONE SECRETION; RENIN-ALDOSTERONE; ACUTE-HYPOXIA; HOMEOSTASIS AB To determine the effect of altitude acclimatization on plasma levels of atrial natriuretic peptide (ANP) during submaximal exercise and its relationship with renin and aldosterone, seven male volunteers aged 17-23 yr exercised to exhaustion on a cycle ergometer at 80-85% of their maximum O2 uptake at sea level (SL; 50 m), during 1 h in a hypobaric chamber [acute altitude (AA); 4,300 m], and after 14 or 16 days of residence on the summit of Pikes Peak, CO [chronic altitude (CA); 4,300 m]. Plasma samples taken before exercise, 10 min after the start of exercise, and 5 min postexercise were analyzed for ANP, plasma renin activity (PRA), and aldosterone (ALDO). ANP showed a progressive increase from rest to postexercise [7.49 +/-1.63 to 11.32 +/- 1.80 (SE) pmol/ml and 6.05 +/- 2.55 to 10.38 +/-7.20 pmol/ml; P = 0.049, exercise] at SL and AA, respectively, but not at CA (P = 0.039, altitude). Similarly, PRA and ALDO rose from rest to postexercise (P < 0.001, exercise), but the rise in ALDO with exercise was less during AA than during SL and CA (P = 0.002, phase). The decreased ANP levels during exercise after altitude acclimatization, with no change in PRA and ALDO, suggest that ANP has little effect on PRA and ALDO under these conditions. C1 USA,ENVIRONM MED RES INST,DIV OCCUPAT PHYSIOL,NATICK,MA 01760. USA,ENVIRONM MED RES INST,DIV MIL NUTR,NATICK,MA 01760. RP ROCK, PB (reprint author), USA,ENVIRONM MED RES INST,DIV ALTITUDE PHYSIOL & MED,NATICK,MA 01760, USA. NR 38 TC 16 Z9 16 U1 0 U2 0 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 8750-7587 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD SEP PY 1993 VL 75 IS 3 BP 1208 EP 1215 PG 8 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA LY896 UT WOS:A1993LY89600026 PM 8226531 ER PT J AU SASSER, LB CUSHING, JA DACRE, JC AF SASSER, LB CUSHING, JA DACRE, JC TI DOMINANT LETHAL STUDY OF SULFUR MUSTARD IN MALE AND FEMALE RATS SO JOURNAL OF APPLIED TOXICOLOGY LA English DT Article DE DOMINANT LETHAL; SULFUR MUSTARD ID SALMONELLA; MOUSE; ASSAY AB Sulfur mustard (HD) (bis(2-chloroethyl)sulfide) is a strong alkylating agent with known mutagenic and suspected carcinogenic properties, but occupational health standards have not been established. The purpose of this study was to determine the dominant lethal effect in male and female rats dosed orally with HD, for which currently available data are ambiguous. Sprague-Dawley rats of each sex, 6-7 weeks old, were orally administered 0, 0.08, 0.20 or 0.50 mg kg-1 HD 5 days a week for 10 weeks, after which dominant lethal studies were conducted during the post-exposure period. The studies were conducted in two phases: a female dominant lethal phase in which treated or untreated males were mated with treated females and their fetuses were evaluated 14 days after copulation; and a male dominant lethal phase in which treated males cohabited with untreated females for 5 days and fetuses were evaluated 14 days after the mid-point of the week of cohabitation, for each of 10 weeks. In addition, motility, population size and morphology were measured in sperm obtained from the cauda epididymis. Parental growth rates were reduced in both sexes treated with the high level of HD. Female dominant lethal effects were not observed, although significant male dominant lethal effects were observed in HD-exposed male rats mated to untreated females at 2 and 3 weeks' post-exposure. These effects, which included increases of early fetal resorptions and preimplantation losses and decrease in total live embryo implants, were most consistently observed at a dose of 0.50 mg kg-1. A significant P(P < 0.05) increase in the percentage of abnormal sperm was detected in males exposed to 0.50 mg kg-1 HD. The timing of dominant lethal effects is consistent with an effect during the post-meiotic stages of spermatogenesis, possibly involving the generally sensitive spermatids. C1 USA, BIOMED RES & DEV LAB, DIV HLTH EFFECTS RES, FT DETRICK, FREDERICK, MD 21702 USA. PACIFIC NW LAB, DEPT BIOL & CHEM, RICHLAND, WA 99352 USA. NR 29 TC 12 Z9 12 U1 0 U2 1 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0260-437X J9 J APPL TOXICOL JI J. Appl. Toxicol. PD SEP-OCT PY 1993 VL 13 IS 5 BP 359 EP 368 DI 10.1002/jat.2550130511 PG 10 WC Toxicology SC Toxicology GA MA784 UT WOS:A1993MA78400009 PM 8258633 ER PT J AU NASEEM, SM PACE, JG AF NASEEM, SM PACE, JG TI EFFECT OF ANTIINFLAMMATORY AGENTS ON RICIN-INDUCED MACROPHAGE TOXICITY SO JOURNAL OF BIOCHEMICAL TOXICOLOGY LA English DT Article DE RICIN TOXICITY; MACROMOLECULE SYNTHESIS; RECEPTOR BINDING; STEROID EFFECT; MEDIATOR RELEASE ID ALVEOLAR MACROPHAGES; A-CHAIN; INHIBITION; STEROIDS; RELEASE; GLUCOCORTICOIDS; GENERATION; PROTEIN; TOXIN; CELLS AB The toxicity of ricin in susceptible cells is well characterized biochemically, but the pathophysiological implications of its toxicity and the immune response to ricin challenge in the lung are unknown. Incubating macrophage cell line with ricin (1 pM-10 nM) for 4 hours markedly inhibited H-3-leucine incorporation (acid insoluble) into protein (> 95%, at 1 nM) without affecting the acid-soluble radioactivity. In spite of increased uptake of total thymidine (141 +/- 13.5%) and total uridine (135 +/- 17.2%), DNA synthesis in ricin-treated cells was progressively inhibited although RNA synthesis was not affected. Fluocinolone (an anti-inflammatory glucocorticoid) pretreatment increased the ricin-induced inhibition of protein synthesis. The synergistic effect of fluocinolone on ricin-induced protein synthesis inhibition was due to an increased binding (167%, p < 0.01) and internalization (134 +/- 12%, p < 0.025) of ricin. Partial protection from ricin-induced inhibition of protein synthesis by indomethacin (nonsteroidal, anti-inflammatory agent) was due to decreased binding and internalization-of ricin. These results show that macrophages are sensitive to ricin and that pharmacologically active drugs may regulate ricin's toxicity, perhaps by controlling synthesis and release of certain mediators of fast death. RP NASEEM, SM (reprint author), USA,MED RES INST INFECT DIS,DIV TOXINOL,FT DETRICK,FREDERICK,MD 21702, USA. NR 28 TC 3 Z9 3 U1 0 U2 0 PU VCH PUBLISHERS INC PI DEERFIELD BEACH PA 303 NW 12TH AVE, DEERFIELD BEACH, FL 33442-1788 SN 0887-2082 J9 J BIOCHEM TOXICOL JI J. Biochem. Toxicol. PD SEP PY 1993 VL 8 IS 3 BP 145 EP 153 DI 10.1002/jbt.2570080306 PG 9 WC Toxicology SC Toxicology GA MA071 UT WOS:A1993MA07100005 PM 7505334 ER PT J AU DOELLGAST, GJ TRISCOTT, MX BEARD, GA BOTTOMS, JD CHENG, T ROH, BH ROMAN, MG HALL, PA BROWN, JE AF DOELLGAST, GJ TRISCOTT, MX BEARD, GA BOTTOMS, JD CHENG, T ROH, BH ROMAN, MG HALL, PA BROWN, JE TI SENSITIVE ENZYME-LINKED-IMMUNOSORBENT-ASSAY FOR DETECTION OF CLOSTRIDIUM-BOTULINUM NEUROTOXIN-A, NEUROTOXIN-B, AND NEUROTOXIN-E USING SIGNAL AMPLIFICATION VIA ENZYME-LINKED COAGULATION ASSAY SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID ANTIBODY-BASED IMMUNOASSAY; AMINO-ACID-COMPOSITION; CURED MEAT SYSTEM; PURE CULTURE; FACTOR-X; TOXIN; PURIFICATION AB A new immunoassay amplification method has been applied to the measurement of toxins A, B, and E from Clostridium botulinum. The technique is a modified enzyme-linked immunosorbent assay (ELISA) which relies on the detection of sandwich complexes on microtiter plates by a solid-phase coagulation assay known as ELCA, or enzyme-linked coagulation assay. In the method, a coagulation activating enzyme (RVV-XA) isolated from the venom of Russell's viper is conjugated to affinity-purified horse antibodies specific for toxin type A, B, or E. Plates are coated with affinity-purified antibodies, and standard captag (capture-tag) protocols using labeled antibody are employed to bind the toxin from solution. Complexes are detected by adding a modified plasma substrate which contains all the coagulation factors mixed with alkaline phosphatase-labeled fibrinogen and solid-phase fibrinogen; deposition of solid-phase, enzyme-labeled fibrin on the solid phase is then a reflection of formation of toxin-RVV-XA-antibody complexes on the solid phase. Because of the ability to detect RVV-XA by this coagulation assay at concentrations < 0. 1 pg/ml, it was possible to measure C. botulinum toxins A, B, and E at mouse bioassay levels (< 10 pg/ml, or < 0.07 pM) for both purified neurotoxin and crude culture filtrates obtained from strains known to produce appropriate single toxins. ELISA-ELCA should be applicable to measurement of toxins in most of the materials (contaminated food, blood, and excreta) for which the comparably sensitive mouse bioassay is currently employed. This method has the potential of broad application to the measurement of low concentrations of any antigen for which appropriate immunochemical reagents are available, in a color test format. C1 ELCATECH INC,WINSTON SALEM,NC 27101. KRAFT GEN FOODS INC,CTR TECHNOL,GLENVIEW,IL 60025. USA,MED RES INST INFECT DIS,FREDERICK,MD 21702. RP DOELLGAST, GJ (reprint author), BOWMAN GRAY SCH MED,DEPT BIOCHEM,100 MED CTR BLVD,WINSTON SALEM,NC 27157, USA. NR 21 TC 68 Z9 69 U1 0 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD SEP PY 1993 VL 31 IS 9 BP 2402 EP 2409 PG 8 WC Microbiology SC Microbiology GA LT813 UT WOS:A1993LT81300027 PM 8408563 ER PT J AU GREM, JL JORDAN, E ROBSON, ME BINDER, RA HAMILTON, JM STEINBERG, SM ARBUCK, SG BEVERIDGE, RA KALES, AN MILLER, JA WEISS, RB MCATEE, N CHEN, A GOLDSPIEL, B SOVER, E ALLEGRA, CJ AF GREM, JL JORDAN, E ROBSON, ME BINDER, RA HAMILTON, JM STEINBERG, SM ARBUCK, SG BEVERIDGE, RA KALES, AN MILLER, JA WEISS, RB MCATEE, N CHEN, A GOLDSPIEL, B SOVER, E ALLEGRA, CJ TI PHASE-II STUDY OF FLUOROURACIL, LEUCOVORIN, AND INTERFERON ALFA-2A IN METASTATIC COLORECTAL-CARCINOMA SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Article ID POLYINOSINIC-POLYCYTIDYLIC ACID; ATLANTIC ONCOLOGY PROGRAM; CELL-LINES; 5-FLUOROURACIL; COMBINATION; MODULATION; ALPHA-2A; TOXICITY; GAMMA; TRIAL C1 NCI,DIV CANC TREATMENT,CLIN ONCOL PROGRAM,BETHESDA,MD 20892. NCI,DIV CANC TREATMENT,CANC THERAPY EVALUAT PROGRAM,BETHESDA,MD 20892. NIH,WARREN G MAGNUSEN CLIN CTR,DEPT PHARM,BETHESDA,MD 20892. USN HOSP,DEPT RADIOL,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. FAIRFAX HEMATOL ONCOL ASSOCIATES,ANNANDALE,VA. NR 34 TC 62 Z9 62 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0732-183X J9 J CLIN ONCOL JI J. Clin. Oncol. PD SEP PY 1993 VL 11 IS 9 BP 1737 EP 1745 PG 9 WC Oncology SC Oncology GA LW369 UT WOS:A1993LW36900015 PM 8355041 ER PT J AU CHASTEN, MA SEABERGH, WC AF CHASTEN, MA SEABERGH, WC TI BEACH RESPONSE AND CHANNEL DYNAMICS AT LITTLE RIVER INLET, NORTH-CAROLINA AND SOUTH-CAROLINA, USA SO JOURNAL OF COASTAL RESEARCH LA English DT Article DE TIDAL INLET; JETTIES; EBB TIDAL DELTA; SHORELINE RESPONSE; SCOUR AB Little River Inlet is a shallow coastal inlet located on the Atlantic Ocean along the North Carolina-South Carolina border. Construction by the U.S. Army Engineer District, Charleston (SAC), of a dual jetty system at Little River Inlet began in March 1981 and was completed in July 1983. A detailed monitoring program conducted from 1979 through 1992 has documented the performance of the Little River Inlet program project. A two-phase analysis of the monitoring data and navigation project was conducted by the Waterways Experiment Station's Coastal Engineering Research Center (CERC). The objectives of the first phase analysis were to summarize beach and nearshore response to the Little River Inlet navigation project and assist SAC in developing disposal plans for maintenance dredged from the inlet. Additionally, the analysis examined if any action should be taken to open the weir sections of either jetty and evaluated the degree of continued project monitoring. The second phase of CERC's analysis conducted a reconnaissance level of review of the post-jetty thalweg evolution and stability, relative inlet hydrodynamics, and scour occurring at the jetty structures. This paper summarizes both phases of the CERC study and performance of the Little River Inlet nagivation project. RP CHASTEN, MA (reprint author), USA,ENGINEER WATERWAYS EXPT STN,COASTAL ENGN RES CTR,VICKSBURG,MS 39180, USA. NR 24 TC 1 Z9 1 U1 0 U2 0 PU COASTAL EDUCATION & RESEARCH FOUNDATION PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 SN 0749-0208 J9 J COASTAL RES JI J. Coast. Res. PD FAL PY 1993 VL 9 IS 4 BP 973 EP 985 PG 13 WC Environmental Sciences; Geography, Physical; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Physical Geography; Geology GA LZ160 UT WOS:A1993LZ16000009 ER PT J AU LIEWEHR, FR KULILD, JC PRIMACK, PD AF LIEWEHR, FR KULILD, JC PRIMACK, PD TI OBTURATION OF A C-SHAPED CANAL USING AN IMPROVED METHOD OF WARM LATERAL CONDENSATION SO JOURNAL OF ENDODONTICS LA English DT Article ID GUTTA-PERCHA AB Pilot studies conducted by the authors seem to indicate that obturation of a root canal system by the lateral condensation of gutta-percha using an electrically heated spreader results in a more homogeneous mass of gutta-percha than standard lateral condensation. This article describes an improved variation which prevents inadvertent dislodgement of the mass of gutta-percha during the obturation. The authors refer to this technique as ''zap and tap'' and a case report describes its use to obturate a C-shaped canal system of a mandibular second molar. C1 USA,POSTGRAD DENT SCH,FT GORDON,GA 30905. NR 9 TC 11 Z9 11 U1 1 U2 1 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0099-2399 J9 J ENDODONT JI J. Endod. PD SEP PY 1993 VL 19 IS 9 BP 474 EP 477 DI 10.1016/S0099-2399(06)80537-6 PG 4 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA LW150 UT WOS:A1993LW15000009 PM 8263457 ER PT J AU TEWARSON, A MACAIONE, DP AF TEWARSON, A MACAIONE, DP TI POLYMERS AND COMPOSITES - AN EXAMINATION OF FIRE SPREAD AND GENERATION OF HEAT AND FIRE PRODUCTS SO JOURNAL OF FIRE SCIENCES LA English DT Article AB Fiber reinforced composite (FRC) materials are used extensively because of their favorable physico-chemical properties and high strength-to-weight ratio. The use of composites in Army vehicles as a means of decreasing weight and enhancing survivability, without reducing personnel safety, has been under study for some time. Although FRC materials are very attractive in terms of their physico-chemical properties, concern for possible fire hazard is understandable as organic polymers are one of the major constituents of the materials. A joint study thus was undertaken by the US. Army Materials Technology Laboratory (MTL) and the Factory Mutual Research Corporation (FMRC) to quantify flammability behavior of selected composite materials for the assessment of fire hazard. In the study, eight FRC materials, identified as MTL #1 to #8, were used. The FRC materials were 3 to 45 mm in thickness. The flammability behavior was examined by using the FMRC Flammability Apparatus (50 kW-Scale) and Oxygen Index (OI) apparatus, Thermogravimetric Analysis (TGA) instrument, NBS smoke chamber (ASTM E 662), and Gas Chromatograph-Mass Spectrometer (GC-MS) instrument at MTL. C1 USA,MAT TECHNOL LAB,WATERTOWN,MA 02172. RP TEWARSON, A (reprint author), FACTORY MUTUAL ENGN & RES CORP,1151 BOSTON PROVIDENCE TURNPIKE,NORWOOD,MA 02062, USA. NR 12 TC 22 Z9 22 U1 0 U2 1 PU TECHNOMIC PUBL CO INC PI LANCASTER PA 851 NEW HOLLAND AVE, BOX 3535, LANCASTER, PA 17604 SN 0734-9041 J9 J FIRE SCI JI J. Fire Sci. PD SEP-OCT PY 1993 VL 11 IS 5 BP 421 EP 441 DI 10.1177/073490419301100504 PG 21 WC Engineering, Multidisciplinary; Materials Science, Multidisciplinary SC Engineering; Materials Science GA LV683 UT WOS:A1993LV68300004 ER PT J AU CURLEY, A URICH, R AF CURLEY, A URICH, R TI THE FLOOD OF 93 - AN ECOLOGICAL PERSPECTIVE SO JOURNAL OF FORESTRY LA English DT Article RP CURLEY, A (reprint author), USA CORPS ENGINEERS,LA CRESCENT,MN, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SOC AMER FORESTERS PI BETHESDA PA 5400 GROSVENOR LANE, BETHESDA, MD 20814 SN 0022-1201 J9 J FOREST JI J. For. PD SEP PY 1993 VL 91 IS 9 BP 28 EP 30 PG 3 WC Forestry SC Forestry GA LV686 UT WOS:A1993LV68600012 ER PT J AU ENK, AH ANGELONI, VL UDEY, MC KATZ, SI AF ENK, AH ANGELONI, VL UDEY, MC KATZ, SI TI INHIBITION OF LANGERHANS CELL ANTIGEN-PRESENTING FUNCTION BY IL-10 - A ROLE FOR IL-10 IN INDUCTION OF TOLERANCE SO JOURNAL OF IMMUNOLOGY LA English DT Article ID ULTRAVIOLET-B RADIATION; T-CELLS; PROLIFERATIVE RESPONSE; CYTOKINE PRODUCTION; CYTOCHROME-C; INTERLEUKIN-10; ACTIVATION; SENSITIVITY; MONOCYTES; CLONES AB IL-10 is a product of activated keratinocytes and is released during the induction phase of contact sensitivity. As IL-10 effects have been described as being mediated by APC, we investigated effects of IL-10 on epidermal Langerhans cells (LC), the resident APC in the epidermis. Initial studies failed to demonstrate effects of IL-10 on MHC class II Ag expression by LC or anti-CD3 mAb- or alloantigen-induced LC-dependent T cell proliferation. However, production of IFN-gamma and IL-2, (but not IL-6) was markedly reduced in these assays. When the soluble-protein Ag specific T cell clones AE7 (Th1) and D10.G4 (Th2) were substituted for unprimed T cells, differential effects of IL-10 on T-cell proliferation were observed. Whereas IL-10-pretreated and untreated LC supported Th2 cell proliferation equally well, IL-10-pretreated LC were essentially unable to induce Th1 cell proliferation in response to native protein or peptide Ag. The inhibitory influence of IL-10 on Th1 cells was observed when fresh or 1 day cultured LC were used; 2- or 3-day cultured LC were affected to a much lesser extent by IL-10 pretreatment. Further, coculture experiments using IL-10-pretreated or untreated LC of a different haplotype suggest that IL-10 negatively regulates a costimulatory signal required for induction of Th1 cell proliferation. To assess whether T cells incubated with Ag and IL-10-pretreated LC were responsive to further stimulation, T cells were rescued after 1 day of coculture with IL-10-pretreated LC and restimulated, either immediately or after 1 to 5 days of rest, with untreated LC in the presence of Ag. T cells incubated with IL-10-pretreated LC were found to be anergic, whereas T cells incubated with untreated LC proliferated normally after further stimulation. However, anergic T cells responded vigorously to IL-2. These data indicate that although IL-10-pretreated LC are effective APC for Th2 cells, they fail to induce Th1 cell proliferation and rather induce clonal anergy in these cells. C1 NCI,DERMATOL BRANCH,BLDG 10,ROOM 12N-238,BETHESDA,MD 20892. UNIV MAINZ,DERMATOL BRANCH,W-6500 MAINZ,GERMANY. WALTER REED ARMY MED CTR,DEPT DERMATOL,WASHINGTON,DC 20307. NR 26 TC 475 Z9 482 U1 1 U2 2 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD SEP 1 PY 1993 VL 151 IS 5 BP 2390 EP 2398 PG 9 WC Immunology SC Immunology GA LV434 UT WOS:A1993LV43400005 PM 8103065 ER PT J AU TAYLOR, KL MURPHY, PC ASHER, LVS LEDUC, JW LEMON, SM AF TAYLOR, KL MURPHY, PC ASHER, LVS LEDUC, JW LEMON, SM TI ATTENUATION PHENOTYPE OF A CELL CULTURE-ADAPTED VARIANT OF HEPATITIS-A VIRUS (HM175/P16) IN SUSCEPTIBLE NEW-WORLD OWL MONKEYS SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID COMPLETE NUCLEOTIDE-SEQUENCE; WILD-TYPE VIRUS; SERIAL PASSAGE; VACCINE; REPLICATION; INVITRO; STRAINS; LIVE; IMMUNOGENICITY; PROPAGATION AB The virulence of a clonally isolated, cell culture-adapted hepatitis A virus (HM175/p16) was assessed in 4 seronegative owl monkeys inoculated intravenously with 2.8 X 10(4) radioimmunofocus-forming units of virus. The virus was highly attenuated, even though its complete nucleotide sequence contains only 19 mutations from the wild-type genome. Only 3 monkeys developed antibodies to hepatitis A virus (only 2 within 96 days of virus inoculation). One monkey had viremia and significantly elevated serum aminotransferase levels. In this animal, maximum viremia and fecal shedding of virus occurred 30-33 days after inoculation. In contrast, in earlier studies of a related cell culture-adapted but still hepatovirulent virus (HM175/S18), viremia was documented in 6 of 6 animals and peak viremia and fecal shedding of virus occurred 18 or 19 days after intravenous inoculation of about one-tenth as much virus. C1 USA,MED RES INST INFECT DIS,FREDERICK,MD 21701. WALTER REED ARMY INST RES,WASHINGTON,DC 20307. FU NIAID NIH HHS [AI-32599] NR 32 TC 9 Z9 9 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD SEP PY 1993 VL 168 IS 3 BP 592 EP 601 PG 10 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA LU337 UT WOS:A1993LU33700009 PM 8102629 ER PT J AU LONGER, CF DENNY, SL CAUDILL, JD MIELE, TA ASHER, LVS MYINT, KSA HUANG, CC ENGLER, WF LEDUC, JW BINN, LN TICEHURST, JR AF LONGER, CF DENNY, SL CAUDILL, JD MIELE, TA ASHER, LVS MYINT, KSA HUANG, CC ENGLER, WF LEDUC, JW BINN, LN TICEHURST, JR TI EXPERIMENTAL HEPATITIS-E - PATHOGENESIS IN CYNOMOLGUS MACAQUES (MACACA-FASCICULARIS) SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID NON-B-HEPATITIS; TRANSMITTED NON-A; POLYMERASE CHAIN-REACTION; LINKED-IMMUNOSORBENT-ASSAY; PUTATIVE CAUSATIVE VIRUS; ETIOLOGIC AGENT; NUCLEIC-ACID; EPIDEMIC; TRANSMISSION; OUTBREAK AB The pathogenesis of experimental hepatitis E has not been thoroughly investigated. The purpose of this study was to more accurately document the events in this disease. Cynomolgus macaques were inoculated intravenously with bile or feces containing hepatitis E virus (HEV). Serum, bile, and liver specimens were evaluated with light microscopy, immune electron microscopy, immunofluorescence microscopy, EIA, and polymerase chain reaction. In the third week, there were histopathologic changes and HEV antigen (HEVAg) in liver, HEV in bile, and alanine aminotransferase (ALT) elevations. Widespread pathologic changes were detected during the fourth week and antibody to HEV (anti-HEV) and peak ALT values in the fifth or sixth week. By the sixth week, HEVAg had disappeared but pathologic changes persisted. This study supports the concept that experimental hepatitis E has an initial phase in which hepatic HEV replication is accompanied by the onset of hepatitis and a later phase in which the appearance of anti-HEV is accompanied by progression of the hepatitis. C1 WALTER REED ARMY INST RES,DIV PATHOL,WASHINGTON,DC 20307. AMER REGISTRY PATHOL,DEPT CARDIOVASC PATHOL,WASHINGTON,DC. AMER REGISTRY PATHOL,DEPT CELLULAR PATHOL,WASHINGTON,DC. ARMED FORCES INST PATHOL,WASHINGTON,DC 20306. USA,MED RES INST INFECT DIS,INST ANIM RESOURCES,FREDERICK,MD 21701. USA,MED RES INST INFECT DIS,DIV DIS ASSESSMENT,FREDERICK,MD 21701. USA,MED COMPONENT,ARMED FORCES RES INST MED SCI,BANGKOK,THAILAND. GENELABS INC,MOLEC VIROL GRP,REDWOOD CITY,CA. RP LONGER, CF (reprint author), WALTER REED ARMY INST RES,DEPT VIRUS DIS,DIV COMMUN DIS & IMMUNOL,WASHINGTON,DC 20307, USA. RI Ticehurst, John/I-7532-2012 NR 47 TC 33 Z9 34 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD SEP PY 1993 VL 168 IS 3 BP 602 EP 609 PG 8 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA LU337 UT WOS:A1993LU33700010 PM 8354901 ER PT J AU GREEN, MS COHEN, D LERMAN, Y SJOGREN, M BINN, LN ZUR, S SLEPON, R ROBIN, G HOKE, C BANCROFT, W SAFARY, A DANON, Y WIENER, M AF GREEN, MS COHEN, D LERMAN, Y SJOGREN, M BINN, LN ZUR, S SLEPON, R ROBIN, G HOKE, C BANCROFT, W SAFARY, A DANON, Y WIENER, M TI DEPRESSION OF THE IMMUNE-RESPONSE TO AN INACTIVATED HEPATITIS-A VACCINE ADMINISTERED CONCOMITANTLY WITH IMMUNE GLOBULIN SO JOURNAL OF INFECTIOUS DISEASES LA English DT Note ID SERUM GLOBULIN; ISRAEL; VIRUS AB Inactivated hepatitis A virus (HAV) vaccine is given in a three-dose schedule. When rapid protection is needed, injection of immune globulin (IG) concomitantly with the first dose could provide passive protection until adequate active antibody response has developed. A possible effect of IG on the immune response to the vaccine was studied in healthy volunteers; 28 received vaccine alone, and 34 received the first dose simultaneously with 5 mL of IG. A control group received hepatitis B vaccine, and a fourth group received IG alone. Four weeks after the first vaccine dose. all subjects had detectable ELISA anti-HAV antibodies. Several weeks after each vaccine dose, the geometric mean titer of antibodies was significantly lower in those who received vaccine with IG but higher than in those who received IG alone. Results for neutralizing antibodies yielded a similar trend. If IG is given with HAV vaccine, a further booster vaccine dose may be required to ensure long-lasting immunity. C1 ISRAEL DEF FORCES,MED CORPS,TEL AVIV,ISRAEL. SMITHKLINE BEECHAM BIOL,RIXENSART,BELGIUM. USA,MED RES INST INFECT DIS,FREDERICK,MD 21701. WALTER REED ARMY INST RES,WASHINGTON,DC 20307. NR 14 TC 45 Z9 44 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD SEP PY 1993 VL 168 IS 3 BP 740 EP 743 PG 4 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA LU337 UT WOS:A1993LU33700031 PM 8394864 ER PT J AU TALLER, AM XIAO, SY GODEC, MS GLIGIC, A AVSICZUPANC, T GOLDFARB, LG YANAGIHARA, R ASHER, DM AF TALLER, AM XIAO, SY GODEC, MS GLIGIC, A AVSICZUPANC, T GOLDFARB, LG YANAGIHARA, R ASHER, DM TI BELGRADE VIRUS, A CAUSE OF HEMORRHAGIC-FEVER WITH RENAL SYNDROME IN THE BALKANS, IS CLOSELY-RELATED TO DOBRAVA VIRUS OF FIELD MICE SO JOURNAL OF INFECTIOUS DISEASES LA English DT Note ID POLYMERASE CHAIN-REACTION; PRIMER PAIR; HANTAVIRUS; AMPLIFICATION; YUGOSLAVIA; RNA; SEQUENCES AB Belgrade virus is a recently described hantavirus that causes severe hemorrhagic fever with renal syndrome (HFRS) in people living in various parts of the Balkan Peninsula. Nucleotide sequencing of the G2-encoding region in the medium (M) segment of the viral genome, reverse transcribed and amplified by the polymerase chain reaction, revealed the Belgrade virus to be substantially different from Hantaan virus and other major serotypes of hantavirus but identical to Dobrava virus, a virus isolated from a field mouse (Apodemus flavicollis) in Slovenia. Belgrade virus may be an important cause of HFRS in the Balkan Peninsula, extending north toward the Alps. It poses a special danger to humans who have close contact with field rodents. C1 NINCDS,CENT NERVOUS SYST STUDIES LAB,BETHESDA,MD 20892. USA,MED RES INST INFECT DIS,FREDERICK,MD 21701. INST IMMUNOL & VIROL,BELGRADE,YUGOSLAVIA. INST MICROBIOL,LJUBLJANA,SLOVENIA. RI Xiao, Shu-Yuan/E-2215-2012 NR 15 TC 17 Z9 18 U1 1 U2 1 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD SEP PY 1993 VL 168 IS 3 BP 750 EP 753 PG 4 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA LU337 UT WOS:A1993LU33700034 PM 8102632 ER PT J AU AMERASINGHE, FP BREISCH, NL NEIDHARDT, K PAGAC, B SCOTT, TW AF AMERASINGHE, FP BREISCH, NL NEIDHARDT, K PAGAC, B SCOTT, TW TI INCREASING DENSITY AND BORRELIA-BURGDORFERI INFECTION OF DEER-INFESTING IXODES-DAMMINI (ACARI, IXODIDAE) IN MARYLAND SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE IXODES-DAMMINI; BORRELIA-BURGDORFERI; MARYLAND DISTRIBUTION ID WHITE-TAILED DEER; LYME-DISEASE SPIROCHETE; NEW-YORK; PREVALENCE; WISCONSIN; TICKS; MASSACHUSETTS; CONNECTICUT; COUNTY; USA AB A statewide survey of Ixodes dammini Spielman was done in November 1991 as a follow-up to a study in 1989. In total, 3,434 adult ticks were collected from 922 hunter-killed white-tailed deer processed at 22 check stations (1 per county in 22 of 23 counties in the state). Significantly more male than female ticks were collected. Tick infestation was significantly heavier on male than female deer. The pattern of tick distribution was similar to that in 1989, with low prevalence (percentage tick-infested deer) and abundance (mean ticks per deer) in the Appalachian region, moderate values in the Piedmont, and high values in the western and eastern Coastal Plains regions. The pattern of tick infection with Borrelia burgdorferi spirochetes (determined by polyclonal immunofluorescence assay) was similar to the tick distributional pattern. Overall, tick prevalence and abundance were higher in 1991 than in 1989, as was the spirochete infection rate in ticks. Multiple regression analysis of tick prevalence against six selected physical and biotic parameters (elevation, rainfall, summer and winter temperature, percentage of forest land, deer density) showed a significant relationship with rainfall and elevation in 1989 and elevation alone in 1991. A more extensive study in Caroline and Dorchester counties in the eastern Coastal Plains region (which showed exceptionally low tick density indices in a generally tick-abundant region in 1989) demonstrated that I. dammini was well established in Caroline but not in Dorchester County. C1 USA,ENVIRONM HYG ACTIV,DIV ENTOMOL SCI,FT GEORGE G MEADE,MD 20755. UNIV MARYLAND,DEPT ENTOMOL,COLL PK,MD 20742. NR 24 TC 16 Z9 16 U1 0 U2 3 PU ENTOMOL SOC AMER PI LANHAM PA 9301 ANNAPOLIS RD, LANHAM, MD 20706 SN 0022-2585 J9 J MED ENTOMOL JI J. Med. Entomol. PD SEP PY 1993 VL 30 IS 5 BP 858 EP 864 PG 7 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA LV977 UT WOS:A1993LV97700003 PM 8254631 ER PT J AU STRICKMAN, D KITTAYAPONG, P AF STRICKMAN, D KITTAYAPONG, P TI LABORATORY DEMONSTRATION OF OVIPOSITION BY AEDES-AEGYPTI (DIPTERA, CULICIDAE) IN COVERED WATER JARS SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Note DE AEDES-AEGYPTI; OVIPOSITION; WATER-JAR COVERS AB In Thailand, ceramic jars (135-200 liters) covered by aluminum lids commonly are used to store water for household use. In laboratory cages, gravid female Aedes aegypti (L.) were able to enter and oviposit in a covered water jar. Although the aluminum lid was not a complete barrier to gravid females, it reduced the number of eggs oviposited by 77%. A vertically oriented foam rubber ring which was compressed between the lip of the jar and the flange of the lid effectively sealed the jar against ovipositing mosquitoes. C1 MAHIDOL UNIV,FAC SCI,DEPT BIOL,BANGKOK 10700,THAILAND. USA,MED COMPONENT,ARMED FORCES RES INST MED SCI,DEPT MED ENTOMOL,APO AP 96546,BANGKOK,THAILAND. NR 7 TC 16 Z9 17 U1 1 U2 2 PU ENTOMOL SOC AMER PI LANHAM PA 9301 ANNAPOLIS RD, LANHAM, MD 20706 SN 0022-2585 J9 J MED ENTOMOL JI J. Med. Entomol. PD SEP PY 1993 VL 30 IS 5 BP 947 EP 949 PG 3 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA LV977 UT WOS:A1993LV97700019 PM 8254646 ER PT J AU MCCARROLL, JE URSANO, RJ FULLERTON, CS LUNDY, A AF MCCARROLL, JE URSANO, RJ FULLERTON, CS LUNDY, A TI TRAUMATIC STRESS OF A WARTIME MORTUARY - ANTICIPATION OF EXPOSURE TO MASS DEATH SO JOURNAL OF NERVOUS AND MENTAL DISEASE LA English DT Article ID EVENT SCALE; DISASTER; IMPACT; VALIDATION; RESPONSES; VICTIMS AB Exposure to traumatic death is a risk factor for posttraumatic stress disorder. For some groups, anticipation of such exposure may contribute to traumatic stress. We studied the anticipated stress of working in the Operation Desert Storm mortuary in two groups prior to the arrival of the dead. We examined those who would handle remains (mortuary workers, N = 386, 330 men and 56 women) and those who would not (support workers. N = 87, 67 men and 20 women). These two groups were a mixture of volunteers and nonvolunteers as well as persons with and without experience in handling the dead. The mortuary workers had higher levels of preexposure distress than support workers; nonvolunteer mortuary workers had higher levels of distress than volunteers. Female mortuary workers had higher levels of distress than males, although this effect was modest. Experienced mortuary workers reported fewer intrusive and avoidant symptoms than did inexperienced workers. Those persons at highest risk for generalized distress as well as intrusive and avoidant symptoms were inexperienced nonvolunteer mortuary workers. C1 UNIFORMED SERV UNIV HLTH SCI,F EDWARD HEBERT SCH MED,DEPT PSYCHIAT,BETHESDA,MD 20814. THOMAS JEFFERSON UNIV,JEFFERSON MED COLL,DEPT PSYCHIAT & HUMAN BEHAV,PHILADELPHIA,PA 19107. RP MCCARROLL, JE (reprint author), WALTER REED ARMY INST RES,DEPT MIL PSYCHIAT,WASHINGTON,DC 20307, USA. NR 21 TC 19 Z9 19 U1 0 U2 3 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-3018 J9 J NERV MENT DIS JI J. Nerv. Ment. Dis. PD SEP PY 1993 VL 181 IS 9 BP 545 EP 551 DI 10.1097/00005053-199309000-00003 PG 7 WC Clinical Neurology; Psychiatry SC Neurosciences & Neurology; Psychiatry GA LX800 UT WOS:A1993LX80000003 PM 8245922 ER PT J AU MILNER, EA CIOFFI, WG MASON, AD MCMANUS, WF PRUITT, BA AF MILNER, EA CIOFFI, WG MASON, AD MCMANUS, WF PRUITT, BA TI ACCURACY OF URINARY UREA NITROGEN FOR PREDICTING TOTAL URINARY NITROGEN IN THERMALLY INJURED PATIENTS SO JOURNAL OF PARENTERAL AND ENTERAL NUTRITION LA English DT Article ID CLINICAL NUTRITION; BALANCE AB Estimations of total urinary nitrogen from measured urinary urea nitrogen are commonly used in calculating nitrogen balance. Recently published studies suggest the urinary urea nitrogen/total urinary nitrogen relationship is inconstant and total urinary nitrogen must be directly measured in burned patients. This study addresses the relationship of urinary urea nitrogen to total urinary nitrogen after thermal injury. Two hundred random 24-hour urine collections obtained from 45 thermally injured patients (mean burn size 59 +/- 28%, mean age 40.5 +/- 17.2 years) between 1 and 354 days postburn were analyzed for total urinary nitrogen and urinary urea nitrogen. Regression analysis relating total urinary nitrogen to estimated total urinary nitrogen (urinary urea nitrogen x 1.25) revealed a linear relationship (r = .936, p <.001). The mean urinary urea nitrogen/total urinary nitrogen ratio was 0.77 +/- 0.10 and was not significantly correlated with percent burn, age, or postburn day. Mean nitrogen balance calculated from measured urinary urea nitrogen in these patients was -5.7 g, and that calculated from measured total urinary nitrogen was -6.3 g. This difference, although statistically significant, is of little consequence for clinical use. Contrary to recent reports, we found the urinary urea nitrogen to be sufficiently predictive of total urinary nitrogen for practical application, and do not consider routine total urinary nitrogen measurements necessary for the nutritional care of thermally injured patients. C1 USA,INST SURG RES,FT SAM HOUSTON,TX 78234. NR 8 TC 18 Z9 20 U1 0 U2 0 PU AMER SOC PARENTERAL & ENTERAL NUTRITION PI SILVER SPRING PA 8630 FENTON STREET SUITE 412, SILVER SPRING, MD 20910 SN 0148-6071 J9 JPEN-PARENTER ENTER JI J. Parenter. Enter. Nutr. PD SEP-OCT PY 1993 VL 17 IS 5 BP 414 EP 416 DI 10.1177/0148607193017005414 PG 3 WC Nutrition & Dietetics SC Nutrition & Dietetics GA LY893 UT WOS:A1993LY89300005 PM 8289405 ER PT J AU GREENBERG, DN ASCHER, DP YODER, BA HENSLEY, DM HEIMAN, HS KEITH, JF AF GREENBERG, DN ASCHER, DP YODER, BA HENSLEY, DM HEIMAN, HS KEITH, JF TI GROUP-B STREPTOCOCCUS SEROTYPE-V SO JOURNAL OF PEDIATRICS LA English DT Letter C1 WILFORD HALL USAF, MED CTR, CLIN INVEST DIRECTORATE, SAN ANTONIO, TX 78250 USA. BROOKE ARMY MED CTR, DEPT PEDIAT, FT SAM HOUSTON, TX 78234 USA. USN HOSP, DEPT PEDIAT, SAN DIEGO, CA 92134 USA. RP GREENBERG, DN (reprint author), WILFORD HALL USAF, MED CTR, DEPT PEDIAT, SAN ANTONIO, TX 78250 USA. NR 3 TC 9 Z9 9 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0022-3476 EI 1097-6833 J9 J PEDIATR-US JI J. Pediatr. PD SEP PY 1993 VL 123 IS 3 BP 494 EP 495 DI 10.1016/S0022-3476(05)81778-0 PG 2 WC Pediatrics SC Pediatrics GA LW160 UT WOS:A1993LW16000038 PM 8355135 ER PT J AU VAUGHAN, GM AF VAUGHAN, GM TI NEW SENSITIVE SERUM MELATONIN RADIOIMMUNOASSAY EMPLOYING THE KENNAWAY G280 ANTIBODY - SYRIAN-HAMSTER MORNING ADRENERGIC RESPONSE SO JOURNAL OF PINEAL RESEARCH LA English DT Article DE PINEAL; SERUM; MELATONIN; ASSAY VALIDATION; SYRIAN HAMSTER; ISOPROTERENOL; ADRENERGIC RESPONSE ID PINEAL N-ACETYLTRANSFERASE; PLASMA MELATONIN; CIRCADIAN-RHYTHM; MASS-SPECTROMETRY; GONADAL ATROPHY; DARK PHASE; SECRETION; HUMANS; GLAND; LIGHT AB A new procedure with the G280 antibody of Kennaway provides an assay for circulating melatonin (aMT) with a sample volume (200 mul), an analytic (0.33 pg/ml) and functional (0.62-0.80 pg/ml) detectability, a 50% displacement dose (6.4 pg/ml), a Kd (0.657 pM), and measured circulating daytime levels lower than reported for previous procedures, and 100% assay recovery. The normal daytime range in adult human and Syrian hamster serum was 0.4-4 pg/ml. The pattern of fall of the nocturnal surge of Syrian hamster serum aMT near the time of lights-on was unaltered by extended darkness. Isoproterenol (ISO) injection 1 hr after lights-on, when aMT had reached daytime levels, raised serum and pineal aMT dramatically 2 hr postinjection. The same dose of ISO injected 4 hr into light produced only a small detectable increase. Novel extension of nocturnal darkness did not affect the responses to ISO. Thus, when they are allowed to occur at the usual time on a 10-hr dark schedule, both the fall from the nocturnal aMT surge and the subsequent loss of pineal beta-adrenergic responsiveness in this species occur endogenously (probably entrained) rather than from gating by acute effects of morning light. Changes in daytime serum aMT consistent with concomitant changes in the pineal can be measured with a sufficiently sensitive radioimmunoassay. RP VAUGHAN, GM (reprint author), USA,INST SURG RES,BLDG 2653,FT SAM HOUSTON,TX 78234, USA. NR 64 TC 69 Z9 69 U1 0 U2 3 PU MUNKSGAARD INT PUBL LTD PI COPENHAGEN PA 35 NORRE SOGADE, PO BOX 2148, DK-1016 COPENHAGEN, DENMARK SN 0742-3098 J9 J PINEAL RES JI J. Pineal Res. PD SEP PY 1993 VL 15 IS 2 BP 88 EP 103 DI 10.1111/j.1600-079X.1993.tb00514.x PG 16 WC Endocrinology & Metabolism; Neurosciences; Physiology SC Endocrinology & Metabolism; Neurosciences & Neurology; Physiology GA MJ704 UT WOS:A1993MJ70400004 PM 8283389 ER PT J AU WARREN, SD ASCHMANN, SG AF WARREN, SD ASCHMANN, SG TI REVEGETATION STRATEGIES FOR KAHOOLAWE ISLAND, HAWAII SO JOURNAL OF RANGE MANAGEMENT LA English DT Article DE FERTILIZATION; JUTE NETTING; WINDBREAK FENCE; DRILL SEEDING AB Over the past 2 centuries, the island of Kaho'olawe has suffered the ravages of war, slash-and-burn agriculture, and overgrazing. Today, much of the island is barren and severely eroded. A research project initiated in 1988 has sought to identify effective, economical techniques to revegetate portions of the island. Treatments included drill seeding plus several rates of fertilization with monoammonium phosphate (11-52-0). Some treatments also include jute netting for soil moisture conservation and erosion control. The effect of windbreak fencing was evaluated across all treatments. Drill seeding plus broadcast application of at least 62 kg ha-1 N plus 291 kg ha-1 P(2)0(5) was the most cost-effective treatment. Jute netting and windbreak fencing significantly enchanced plant production, but the high cost of materials and maintenance limits their use to critical areas. The planted species with greatest promise for the windy, semiarid conditions on Kaho'olawe were buffelgrass (Cenchrus ciliaris L.), bermudagrass [Cynodon dactylon (L.) Pers.] and weeping lovegrass [Eragrostis curvula (Schrad.) Nees]. Although not included in the seed mixture, Australian saltbush (A triplex semibaccata R. Br.), a naturalized species, responded favorably to fertilization. A subsequent, larger-scale revegetation project using a specially modified chisel plow seeder to scarify, plant, and apply in-furrow fertilization in a single-pass operation reduced the cost and improved the results of the revegetation process. C1 USN,FACIL ENGN COMMAND,PACIFIC DIV,HONOLULU,HI 96860. RP WARREN, SD (reprint author), USA,CONSTRUCT ENGN RES LABS,ENVIRONM SUSTAINMENT LAB,POB 9005,CHAMPAIGN,IL 61826, USA. NR 19 TC 7 Z9 7 U1 1 U2 5 PU SOC RANGE MANAGEMENT PI DENVER PA 1839 YORK ST, DENVER, CO 80206 SN 0022-409X J9 J RANGE MANAGE JI J. Range Manage. PD SEP PY 1993 VL 46 IS 5 BP 462 EP 466 DI 10.2307/4002668 PG 5 WC Agriculture, Dairy & Animal Science; Ecology SC Agriculture; Environmental Sciences & Ecology GA LY502 UT WOS:A1993LY50200016 ER PT J AU KARLE, JM OLMEDA, R PARK, AS AF KARLE, JM OLMEDA, R PARK, AS TI AMINOSULFHYDRYL AND AMINODISULFIDE COMPOUNDS ENHANCE BINDING OF THE GLUCOCORTICOID RECEPTOR COMPLEX TO DEOXYRIBONUCLEIC ACID-COATED CELLULOSE AND TO CHROMATIN SO JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY LA English DT Article ID RAT-LIVER CYTOSOL; DNA-BINDING; DEXAMETHASONE 21-MESYLATE; SULFHYDRYL-GROUPS; TRANSCRIPTIONAL ENHANCEMENT; HORMONE RECEPTORS; ACTIVATING FACTOR; STEROID-BINDING; MOUSE; IDENTIFICATION AB In the presence of amine-containing sulfhydryl compounds, binding of heat-transformed cytosolic mt liver glucocorticoid receptor complex (GRC) to double-stranded calf thymus DNA-coated cellulose and to rat liver chromatin was enhanced up to 10-fold. These observations were made under conditions when a maximum of 8% of the total GRC bound to DNA in the absence of test compound. Compounds which did not contain both a sulfhydryl and amine group were inactive. Phosphorothioate derivatives of the active sulfhydryl compounds were also inactive. However, pretreatment of the phosphorothioate compounds with alkaline phosphatase restored activity. Upon centrifugation at 8800g, amine-containing disulfide compounds at millimolar concentrations caused considerable sedimentation of the GRC in the absence of DNA-coated cellulose or chromatin and no apparent increase in GRC binding to DNA or chromatin. Amine-containing disulfide compounds at micromolar concentrations did not cause heavy sedimentation of the GRC and enhanced binding of the GRC to DNA-coated cellulose up to 9.5-fold. Thus, diaminosulfhydryl compounds and the disulfide 1,18-diamino-6,13-diaza-9,10-dithiaoctadecane (WR 149,024) possess both the ability to restore and preserve the steroid binding capacity of the glucocorticoid receptor and to enhance binding of the GRC to DNA and chromatin. RP KARLE, JM (reprint author), WALTER REED ARMY INST RES,DEPT PHARMACOL,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307, USA. NR 52 TC 0 Z9 0 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0960-0760 J9 J STEROID BIOCHEM JI J. Steroid Biochem. Mol. Biol. PD SEP PY 1993 VL 46 IS 3 BP 289 EP 297 DI 10.1016/0960-0760(93)90218-L PG 9 WC Biochemistry & Molecular Biology; Endocrinology & Metabolism SC Biochemistry & Molecular Biology; Endocrinology & Metabolism GA LY881 UT WOS:A1993LY88100003 PM 9831477 ER PT J AU RINNOVATORE, JV LUKENS, KF REINHOLD, J MAHON, W AF RINNOVATORE, JV LUKENS, KF REINHOLD, J MAHON, W TI EMBRITTLEMENT OF AN AISI-8640 LOWER BAINITE STEEL SO JOURNAL OF TESTING AND EVALUATION LA English DT Article DE EMBRITTLEMENT; FRACTURE TOUGHNESS; CHARPY IMPACT; TRANSITION TEMPERATURE; 8640-ALLOY STEEL; PHOSPHORUS; ARSENIC; BAINITE AB A study was performed to determine the cause of an abnormally low fracture toughness of an AISI 8640 resulfurized steel. The embrittlement effects of phosphorus and arsenic on this steel heat-treated to a lower bainitic structure were studied by employing fracture toughness tests, Charpy impact tests, X-ray fluorescent spectroscopy, and scanning electron microscopy (SEM). The results showed that the steel was embrittled by phosphorus at prior austenite grain boundaries in a manner similar to the tempered martensite embrittlement (TME) phenomenon. Arsenic is also believed to be involved in the embrittlement effect, specifically as related to producing a reduction in the upper shelf Charpy impact energy. Embrittlement was manifested by a reduced fracture toughness, an increase in the Charpy transition temperature, and intergranular fracture. C1 USA,CTR DEV & ENGN,ARMAMENT RES,PICATINNY ARSENAL,NJ 07806. RP RINNOVATORE, JV (reprint author), MTA INC,MT ARLINGTON,NJ 07856, USA. NR 13 TC 1 Z9 1 U1 0 U2 0 PU AMER SOC TESTING MATERIALS PI W CONSHOHOCKEN PA 100 BARR HARBOR DR, W CONSHOHOCKEN, PA 19428-2959 SN 0090-3973 J9 J TEST EVAL JI J. Test. Eval. PD SEP PY 1993 VL 21 IS 5 BP 329 EP 338 PG 10 WC Materials Science, Characterization & Testing SC Materials Science GA LU711 UT WOS:A1993LU71100001 ER PT J AU SMITH, KJ SKELTON, HG YEAGER, J ANGRITT, P WAGNER, KF AF SMITH, KJ SKELTON, HG YEAGER, J ANGRITT, P WAGNER, KF TI CUTANEOUS NEOPLASMS IN A MILITARY POPULATION OF HIV-1-POSITIVE PATIENTS SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; BASAL-CELL CARCINOMA; HUMAN PAPILLOMAVIRUS INFECTION; KAPOSIS-SARCOMA; HIV-INFECTION; IMMUNOSUPPRESSED PATIENTS; SKIN-CANCER; AIDS; RISK; PROGRESSION AB Background. In HIV-1-positive patients there have been no prospective studies that show an increase in cutaneous neoplasms. Objective: We observed HIV-1-positive patients to determine whether or not there was an increased incidence of cutaneous malignancies. Methods. A total of 724 HIV-1-positive patients were examined during a 36-month period for the development of cutaneous malignancies. Results: The most common cutaneous neoplasm found was Kaposi's sarcoma, especially in patients with late-stage disease. Basal cell carcinomas were the next most frequent tumor. We have also seen three malignant melanomas and two squamous cell carcinomas. Five patients had malignant lymphoma. One patient had a primary lymphoma of subcutaneous soft tissue; in one patient multiple cutaneous lesions developed. Conclusion. The distribution and prevalent types of cutaneous neoplasms in HIV-1-positive patients appear to differ from those found in other immunosuppressed populations. This may be the result of the different patterns and periods of immunosuppression in these patients and/or associated cocarcinogens to which these patients frequently are exposed. C1 ARMED FORCES INST PATHOL, DEPT DERMATOL, WASHINGTON, DC 20306 USA. HENRY M JACKSON FDN, ROCKVILLE, MD USA. WALTER REED ARMY INST RES, WASHINGTON, DC 20307 USA. AIDS REGISTRY, WASHINGTON, DC USA. RP SMITH, KJ (reprint author), NATL NAVAL MED CTR, DEPT DERMATOL, BETHESDA, MD 20814 USA. FU NIAMS NIH HHS [NIAMS AYO1AR90008, NIAMS NYO1AR00014] NR 51 TC 49 Z9 50 U1 0 U2 1 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD SEP PY 1993 VL 29 IS 3 BP 400 EP 406 PG 7 WC Dermatology SC Dermatology GA LU963 UT WOS:A1993LU96300004 PM 8349856 ER PT J AU VUKELJA, SJ BAKER, WJ BURRIS, HA KEELING, JH VONHOFF, D AF VUKELJA, SJ BAKER, WJ BURRIS, HA KEELING, JH VONHOFF, D TI PYRIDOXINE THERAPY FOR PALMAR PLANTAR ERYTHRODYSESTHESIA ASSOCIATED WITH TAXOTERE SO JOURNAL OF THE NATIONAL CANCER INSTITUTE LA English DT Letter ID RP-56976; ANALOG; TAXOL C1 BROOKE ARMY MED CTR,DEPT MED,DERMATOL SERV,FT SAM HOUSTON,TX 78234. UNIV TEXAS,HLTH SCI CTR,SAN ANTONIO,TX 78284. RP VUKELJA, SJ (reprint author), BROOKE ARMY MED CTR,DEPT MED,HEMATOL ONCOL SERV,FT SAM HOUSTON,TX 78234, USA. NR 10 TC 42 Z9 43 U1 0 U2 0 PU NATL CANCER INSTITUTE PI BETHESDA PA 9030 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0027-8874 J9 J NATL CANCER I JI J. Natl. Cancer Inst. PD SEP 1 PY 1993 VL 85 IS 17 BP 1432 EP 1433 DI 10.1093/jnci/85.17.1432 PG 2 WC Oncology SC Oncology GA LU580 UT WOS:A1993LU58000018 PM 8102408 ER PT J AU DROST, AC BURLESON, DG CIOFFI, WG JORDAN, BS MASON, AD PRUITT, BA AF DROST, AC BURLESON, DG CIOFFI, WG JORDAN, BS MASON, AD PRUITT, BA TI PLASMA CYTOKINES FOLLOWING THERMAL-INJURY AND THEIR RELATIONSHIP WITH PATIENT MORTALITY, BURN SIZE, AND TIME POSTBURN SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article ID TUMOR-NECROSIS-FACTOR; FACTOR-ALPHA; ENHANCED PRODUCTION; INTERLEUKIN-1; IL-6; ENDOTOXIN; INTERFERON-BETA-2; ACTIVATION; INDUCTION; CACHECTIN AB We measured plasma levels of interleukin-1beta (IL-1beta), tumor necrosis factor alpha (TNFalpha), and interleukin-6 (IL-6) following thermal injury. Cytokine levels in the plasma of 27 burned patients were serially screened by ELISA and compared with cytokine levels in 16 healthy laboratory employees. The relationships between cytokine concentrations and patient mortality, burn size, and time postburn were examined. Plasma samples with detectable amounts of IL-1beta and IL-6 were significantly more frequent in burned patients than in controls, whereas TNFalpha was undetectable in most plasma samples. All nonsurviving burned patients had detectable IL-6 levels; these were significantly higher than those of surviving patients. The IL-1beta and IL-6 concentrations were highest during the first week after injury and declined over time. The IL-1beta concentrations were positively correlated with burn size. These findings suggest that IL-1beta and IL-6 may influence metabolic and immunologic responses in the first few weeks following thermal injury. Tumor necrosis factor alpha was transiently elevated in a small subpopulation of burned patients with no obvious relationship to burn size or time postburn. RP DROST, AC (reprint author), USA,INST SURG RES,FT SAM HOUSTON,TX 78234, USA. NR 28 TC 141 Z9 148 U1 1 U2 2 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 1079-6061 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD SEP PY 1993 VL 35 IS 3 BP 335 EP 339 DI 10.1097/00005373-199309000-00001 PG 5 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA LY242 UT WOS:A1993LY24200001 PM 8371288 ER PT J AU MOUL, JW FOLEY, JP HITCHCOCK, CL MCCARTHY, WF SESTERHENN, IA BECKER, RL GRIFFIN, JL AF MOUL, JW FOLEY, JP HITCHCOCK, CL MCCARTHY, WF SESTERHENN, IA BECKER, RL GRIFFIN, JL TI FLOW CYTOMETRIC AND QUANTITATIVE HISTOLOGICAL PARAMETERS TO PREDICT OCCULT DISEASE IN CLINICAL STAGE-I NONSEMINOMATOUS TESTICULAR GERM-CELL TUMORS SO JOURNAL OF UROLOGY LA English DT Article DE FLOW CYTOMETRY; HISTOLOGY; TESTICULAR NEOPLASMS; GERM CELLS ID DNA CONTENT; PROLIFERATIVE ACTIVITY; MALIGNANT-TUMORS; CANCER; PLOIDY; HISTOPATHOLOGY; PROGNOSIS; TESTIS AB The goal of this study was to determine if deoxyribonucleic acid (DNA) flow cytometric and quantitative histological parameters could predict occult metastases in clinical stage I nonseminomatous testicular cancer. Archival paraffin primary tumor tissue was available from 36 clinical stage I nonseminomatous germ cell testicular cancer patients who all had retroperitoneal lymphadenectomy and followup defining 2 groups: pathological stage I (23) and occult pathological stage II (13). Archival blocks were microdissected and individual histological components were subjected to flow cytometry. In addition, the primary histology was reevaluated for vascular invasion and per cent composition of histological components of embryonal carcinoma and other histologies. For flow cytometry parameters, no tumor was uniformly diploid, and the DNA index and per cent S phase cells were not useful in differentiating stages. Although mean per cent S phase for the aneuploid cell population and proliferative index were significantly greater for stage II cases by univariate logistic regression analysis, they are approximately 70% accurate in predicting occult disease as single tests and were not significant by multivariate analysis. The calculation of per cent embryonal carcinoma was also significantly greater in stage II cancer by univariate logistic regression testing and remained significant by multivariate analysis. Vascular invasion was marginally predictive of occult disease but was also not significant, by multivariate analysis. Calculating the percentage of embryonal carcinoma of a primary testicular tumor may be a useful method to assess clinical stage I cancer patients for risk of occult disease. A larger study is needed to confirm the importance of per cent embryonal carcinoma and to clarify further if flow cytometry in combination is useful. C1 WALTER REED ARMY MED CTR,UROL SERV,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. ARMED FORCES INST PATHOL,DEPT GENITOURINARY PATHOL,WASHINGTON,DC 20306. ARMED FORCES INST PATHOL,DEPT CELLULAR PATHOL,WASHINGTON,DC 20306. HENRY M JACKSON FDN ADVANCEMENT MIL MED,ROCKVILLE,MD. RP MOUL, JW (reprint author), UNIFORMED SERV UNIV HLTH SCI,DEPT SURG,4301 JONES BRIDGE RD,BETHESDA,MD 20814, USA. NR 28 TC 32 Z9 32 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-5347 J9 J UROLOGY JI J. Urol. PD SEP PY 1993 VL 150 IS 3 BP 879 EP 883 PG 5 WC Urology & Nephrology SC Urology & Nephrology GA LR890 UT WOS:A1993LR89000021 PM 8393944 ER PT J AU LEVENTHAL, EK ROZANSKI, TA MOREY, AF RHOLL, V AF LEVENTHAL, EK ROZANSKI, TA MOREY, AF RHOLL, V TI THE EFFECTS OF EXERCISE AND ACTIVITY ON SERUM PROSTATE-SPECIFIC ANTIGEN LEVELS SO JOURNAL OF UROLOGY LA English DT Article DE PROSTATE; ANTIGENS, NEOPLASM; EXERCISE ID MARKER; ADENOCARCINOMA AB To determine the effects of exercise and activity on serum prostate specific antigen (PSA) levels, we studied an inpatient adult male population, and evaluated the PSA levels before and after a graded exercise stress test. We confirmed a prior finding showing a significant difference between inpatient and outpatient values, yet found that stressful exercise had no definitive effect on serum PSA values. RP LEVENTHAL, EK (reprint author), TRIPLER ARMY MED CTR,DEPT SURG,UROL SERV,HONOLULU,HI 96859, USA. NR 10 TC 38 Z9 39 U1 0 U2 1 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-5347 J9 J UROLOGY JI J. Urol. PD SEP PY 1993 VL 150 IS 3 BP 893 EP 894 PG 2 WC Urology & Nephrology SC Urology & Nephrology GA LR890 UT WOS:A1993LR89000024 PM 7688434 ER PT J AU CAMFIELD, FE BRIGGS, MJ AF CAMFIELD, FE BRIGGS, MJ TI LONGSHORE TRANSMISSION OF REFLECTED WAVES SO JOURNAL OF WATERWAY PORT COASTAL AND OCEAN ENGINEERING-ASCE LA English DT Note AB A method is presented for determining the longshore travel distance of wave energy reflected from a coastal structure. These reflected waves may become trapped by refraction, causing reflected wave energy to impact the coastline some distance from the structure. The reflected waves may have a localized effect on coastal processes by adding wave energy to the incident waves along a reach of the coastline, and cause localized erosion as the shoreline adjusts its orientation to reach equilibrium with the reflected waves. The method incorporates consideration of the wave period, and gives results for directional spreading due to wave frequency. A plane bottom slope is assumed. The theoretical development is described and an example is given to illustrate the method. The method presented provides a quick, first-order solution that is an improvement on earlier methodology. RP CAMFIELD, FE (reprint author), USA,WTRWYS EXPT STN,COAST ENGN RES CTR,DIV WAVE DYNAM,VICKSBURG,MS 39180, USA. NR 7 TC 0 Z9 0 U1 0 U2 1 PU ASCE-AMER SOC CIVIL ENGINEERS PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-950X J9 J WATERW PORT C-ASCE JI J. Waterw. Port Coast. Ocean Eng.-ASCE PD SEP-OCT PY 1993 VL 119 IS 5 BP 575 EP 579 DI 10.1061/(ASCE)0733-950X(1993)119:5(575) PG 5 WC Engineering, Civil; Engineering, Ocean; Water Resources SC Engineering; Water Resources GA LU474 UT WOS:A1993LU47400008 ER PT J AU BARTH, J AF BARTH, J TI HERZFELD GUIDE TO CLOSED-END FUNDS - HERZFELD,TJ SO LIBRARY JOURNAL LA English DT Book Review RP BARTH, J (reprint author), US MIL ACAD LIB,W POINT,NY 10996, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 SN 0363-0277 J9 LIBR J JI Libr. J. PD SEP 1 PY 1993 VL 118 IS 14 BP 196 EP 196 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA LW982 UT WOS:A1993LW98200118 ER PT J AU LADE, PV BOPP, PA PETERS, JF AF LADE, PV BOPP, PA PETERS, JF TI INSTABILITY OF DILATING SAND SO MECHANICS OF MATERIALS LA English DT Article ID NONASSOCIATED FLOW; SOILS AB Stability postulates by Drucker and by Hill are applicable to solid metal. When applied to granular material exhibiting nonassociated flow, these concepts of stability imply that the material may be unstable when exposed to certain stress paths inside the failure surface. Series of triaxial tests on fully saturated and partly saturated specimens have been performed under drained and undrained conditions to study the regions of stable and unstable behavior. The stability postulate by Drucker and by Hill do not capture the conditions for stable and unstable behavior of granular materials. The experimentally determined conditions for which granular materials are stable, conditionally unstable, and unconditionally unstable are discussed. C1 GEOSOILS INC,VAN NUYS,CA 91406. USA,ENGINEER WATERWAYS EXPT STN,VICKSBURG,MS 39180. RP LADE, PV (reprint author), UNIV CALIF LOS ANGELES,SCH ENGN & APPL SCI,DEPT CIVIL ENGN,3173 ENGN 1,LOS ANGELES,CA 90024, USA. NR 21 TC 19 Z9 19 U1 1 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-6636 J9 MECH MATER JI Mech. Mater. PD SEP PY 1993 VL 16 IS 3 BP 249 EP 264 DI 10.1016/0167-6636(93)90056-W PG 16 WC Materials Science, Multidisciplinary; Mechanics SC Materials Science; Mechanics GA LY186 UT WOS:A1993LY18600001 ER PT J AU BRAZAITIS, MP DACHMAN, AH AF BRAZAITIS, MP DACHMAN, AH TI THE RADIOLOGIC EVALUATION OF ACUTE ABDOMINAL-PAIN OF INTESTINAL ORIGIN - A CLINICAL APPROACH SO MEDICAL CLINICS OF NORTH AMERICA LA English DT Article ID ACUTE APPENDICITIS; ACUTE ABDOMEN; PERCUTANEOUS DRAINAGE; CT; DIAGNOSIS; DIVERTICULITIS; RADIOGRAPHS; ABSCESSES; DISEASE C1 WALTER REED ARMY MED CTR,DEPT ABDOMINAL RADIOL,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,DEPT RADIOL NUCL MED,BETHESDA,MD 20814. RP BRAZAITIS, MP (reprint author), WALTER REED ARMY MED CTR,DEPT RADIOL,DIAGNOST RADIOL SERV,WASHINGTON,DC 20307, USA. NR 39 TC 6 Z9 6 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0025-7125 J9 MED CLIN N AM JI Med. Clin. N. Am. PD SEP PY 1993 VL 77 IS 5 BP 939 EP 961 PG 23 WC Medicine, General & Internal SC General & Internal Medicine GA LX528 UT WOS:A1993LX52800002 PM 8371622 ER PT J AU BREWER, TG AF BREWER, TG TI TREATMENT OF ACUTE GASTROESOPHAGEAL VARICEAL HEMORRHAGE SO MEDICAL CLINICS OF NORTH AMERICA LA English DT Review ID BLEEDING ESOPHAGEAL-VARICES; LONG-TERM MANAGEMENT; PROSPECTIVE CONTROLLED TRIAL; RANDOMIZED CONTROLLED TRIAL; SENGSTAKEN-BLAKEMORE TUBE; CONTROLLED CLINICAL-TRIAL; PLACEBO-CONTROLLED TRIAL; INTRAHEPATIC PORTOSYSTEMIC SHUNTS; VASOPRESSIN PLUS NITROGLYCERIN; BLOOD-VOLUME RESTITUTION RP BREWER, TG (reprint author), WALTER REED ARMY INST RES,DEPT PHARMACOL,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307, USA. NR 129 TC 13 Z9 13 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0025-7125 J9 MED CLIN N AM JI Med. Clin. N. Am. PD SEP PY 1993 VL 77 IS 5 BP 993 EP 1014 PG 22 WC Medicine, General & Internal SC General & Internal Medicine GA LX528 UT WOS:A1993LX52800005 PM 8371625 ER PT J AU KADAKIA, SC AF KADAKIA, SC TI BILIARY-TRACT EMERGENCIES - ACUTE CHOLECYSTITIS, ACUTE CHOLANGITIS, AND ACUTE-PANCREATITIS SO MEDICAL CLINICS OF NORTH AMERICA LA English DT Review ID BILE-DUCT STONES; ACUTE ACALCULOUS CHOLECYSTITIS; CONTROLLED CLINICAL-TRIAL; ACUTE SUPPURATIVE CHOLANGITIS; ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY; MALIGNANT OBSTRUCTIVE-JAUNDICE; GALLSTONE PANCREATITIS; COMPUTED-TOMOGRAPHY; LAPAROSCOPIC CHOLECYSTECTOMY; ORIENTAL CHOLANGIOHEPATITIS C1 BROOKE ARMY MED CTR,DEPT MED,FT SAM HOUSTON,TX 78234. UNIV TEXAS,HLTH SCI CTR,DEPT MED,SAN ANTONIO,TX 78284. RP KADAKIA, SC (reprint author), BROOKE ARMY MED CTR,GASTROENTEROL SERV,FT SAM HOUSTON,TX 78234, USA. NR 163 TC 13 Z9 13 U1 0 U2 1 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0025-7125 J9 MED CLIN N AM JI Med. Clin. N. Am. PD SEP PY 1993 VL 77 IS 5 BP 1015 EP 1036 PG 22 WC Medicine, General & Internal SC General & Internal Medicine GA LX528 UT WOS:A1993LX52800006 PM 8371614 ER PT J AU DEMARKLES, MP MURPHY, JR AF DEMARKLES, MP MURPHY, JR TI ACUTE LOWER GASTROINTESTINAL-BLEEDING SO MEDICAL CLINICS OF NORTH AMERICA LA English DT Article ID BLOOD-CELL SCINTIGRAPHY; COLONOSCOPIC DIAGNOSIS; VASCULAR ECTASIAS; ARTERIOVENOUS-MALFORMATIONS; INTRAOPERATIVE ENTEROSCOPY; DIVERTICULAR-DISEASE; VASOPRESSIN INFUSION; AORTIC-STENOSIS; SMALL-INTESTINE; HOT BIOPSY C1 UNIFORMED SERV UNIV HLTH SCI,DEPT MED,BETHESDA,MD 20814. RP DEMARKLES, MP (reprint author), WALTER REED ARMY MED CTR,GASTROENTEROL SERV,WASHINGTON,DC 20307, USA. NR 64 TC 38 Z9 39 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0025-7125 J9 MED CLIN N AM JI Med. Clin. N. Am. PD SEP PY 1993 VL 77 IS 5 BP 1085 EP 1100 PG 16 WC Medicine, General & Internal SC General & Internal Medicine GA LX528 UT WOS:A1993LX52800009 PM 8371616 ER PT J AU SJOGREN, MH AF SJOGREN, MH TI HEPATIC EMERGENCIES IN PREGNANCY SO MEDICAL CLINICS OF NORTH AMERICA LA English DT Article ID BUDD-CHIARI SYNDROME; ACUTE FATTY LIVER; VIRAL-HEPATITIS; OBSTETRIC CHOLESTASIS; ORAL-CONTRACEPTIVES; B VIRUS; INFANT TRANSMISSION; C VIRUS; NON-A; DISEASE RP SJOGREN, MH (reprint author), WALTER REED ARMY MED CTR,DEPT GASTROENTEROL,WASHINGTON,DC 20307, USA. NR 82 TC 6 Z9 6 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0025-7125 J9 MED CLIN N AM JI Med. Clin. N. Am. PD SEP PY 1993 VL 77 IS 5 BP 1115 EP 1127 PG 13 WC Medicine, General & Internal SC General & Internal Medicine GA LX528 UT WOS:A1993LX52800011 PM 8371618 ER PT J AU CHENEY, CP WONG, RKH AF CHENEY, CP WONG, RKH TI ACUTE INFECTIOUS DIARRHEA SO MEDICAL CLINICS OF NORTH AMERICA LA English DT Review ID ACQUIRED IMMUNODEFICIENCY SYNDROME; ENTEROPATHOGENIC ESCHERICHIA-COLI; HEAT-STABLE ENTEROTOXIN; DAY-CARE-CENTERS; ANTIBIOTIC-ASSOCIATED COLITIS; TRAVELERS DIARRHEA; UNITED-STATES; CYTO-TOXIN; TRIMETHOPRIM-SULFAMETHOXAZOLE; INTESTINAL INFECTIONS C1 WALTER REED ARMY MED CTR,GASTROENTEROL SERV,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,DEPT MED,BETHESDA,MD 20814. NR 175 TC 17 Z9 17 U1 0 U2 1 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0025-7125 J9 MED CLIN N AM JI Med. Clin. N. Am. PD SEP PY 1993 VL 77 IS 5 BP 1169 EP 1196 PG 28 WC Medicine, General & Internal SC General & Internal Medicine GA LX528 UT WOS:A1993LX52800014 PM 8371621 ER PT J AU WONG, RKH AF WONG, RKH TI GASTROINTESTINAL EMERGENCIES - PREFACE SO MEDICAL CLINICS OF NORTH AMERICA LA English DT Editorial Material RP WONG, RKH (reprint author), WALTER REED ARMY MED CTR,GASTROENTEROL SERV,WASHINGTON,DC 20307, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0025-7125 J9 MED CLIN N AM JI Med. Clin. N. Am. PD SEP PY 1993 VL 77 IS 5 BP R11 EP R11 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA LX528 UT WOS:A1993LX52800001 ER PT J AU LOVEJOY, JK AF LOVEJOY, JK TI ABOLITION OF COURT MEMBER SENTENCING IN THE MILITARY SO MILITARY LAW REVIEW LA English DT Article C1 USA,WASHINGTON,DC 20310. NR 26 TC 4 Z9 4 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD FAL PY 1993 VL 142 BP 1 EP 66 PG 66 WC Law SC Government & Law GA PA228 UT WOS:A1993PA22800001 ER PT J AU STONE, K AF STONE, K TI THE TWILIGHT ZONE - POSTGOVERNMENT EMPLOYMENT RESTRICTIONS AFFECTING RETIRED AND FORMER DEPARTMENT-OF-DEFENSE PERSONNEL SO MILITARY LAW REVIEW LA English DT Article C1 USA,WASHINGTON,DC 20310. NR 16 TC 1 Z9 1 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD FAL PY 1993 VL 142 BP 67 EP 140 PG 74 WC Law SC Government & Law GA PA228 UT WOS:A1993PA22800002 ER PT J AU BORCH, FL AF BORCH, FL TI A HISTORY OF WARFARE - KEEGAN,J SO MILITARY LAW REVIEW LA English DT Book Review RP BORCH, FL (reprint author), USA,COLL GEN STAFF,FT LEAVENWORTH,KS, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD FAL PY 1993 VL 142 BP 181 EP 185 PG 5 WC Law SC Government & Law GA PA228 UT WOS:A1993PA22800005 ER PT J AU ROB, SJ AF ROB, SJ TI THE PRICE OF VICTORY - GREEN,VS SO MILITARY LAW REVIEW LA English DT Book Review RP ROB, SJ (reprint author), USA,DIV CONTRACT APPEALS,BALLSTON,VA, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD FAL PY 1993 VL 142 BP 185 EP 187 PG 3 WC Law SC Government & Law GA PA228 UT WOS:A1993PA22800006 ER PT J AU BORCH, FL AF BORCH, FL TI THE ANATOMY OF THE NUREMBERG TRIALS - TAYLOR,T SO MILITARY LAW REVIEW LA English DT Book Review RP BORCH, FL (reprint author), USA,COLL GEN STAFF,FT LEAVENWORTH,KS, USA. NR 1 TC 0 Z9 0 U1 0 U2 1 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD FAL PY 1993 VL 142 BP 191 EP 193 PG 3 WC Law SC Government & Law GA PA228 UT WOS:A1993PA22800008 ER PT J AU CHISICK, MC AF CHISICK, MC TI DENTAL EPIDEMIOLOGY OF MILITARY OPERATIONS SO MILITARY MEDICINE LA English DT Article AB In this paper we review studies that have been conducted on the epidemiology of oral, dental, and maxillofacial conditions during military deployments. The limitations of our current knowledge base are discussed, as is a proposed research effort to enhance the reponsiveness of dental support in theaters of operation. RP CHISICK, MC (reprint author), USA,INST DENT RES,FT GEORGE G MEADE,MD, USA. NR 0 TC 21 Z9 23 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD SEP PY 1993 VL 158 IS 9 BP 581 EP 585 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA LX041 UT WOS:A1993LX04100005 PM 8232992 ER PT J AU FALCONE, SG AF FALCONE, SG TI DISCHARGE PLANNING AND DIAGNOSIS-RELATED GROUPS IN MILITARY HOSPITALS - KEY ISSUES AND ESSENTIAL ELEMENTS SO MILITARY MEDICINE LA English DT Article AB As pressures for cost containment in health care continue to mount, military hospitals will inevitably be affected. Cost-containment Strategies used in civilian hospitals such as diagnosis-related groups will continue to be implemented in military health care facilities. Effective discharge planning is essential for dealing successfully with pressures for cost containment. Key elements in an effective discharge planning program are discussed. RP FALCONE, SG (reprint author), USA,MED DEPT ACT,FT BELVOIR,VA 22060, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD SEP PY 1993 VL 158 IS 9 BP 591 EP 594 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA LX041 UT WOS:A1993LX04100008 PM 8232995 ER PT J AU WELLFORD, L ASHCOM, TL WHITNEY, EJ RUBAL, BJ WELLFORD, LA MOODY, JM AF WELLFORD, L ASHCOM, TL WHITNEY, EJ RUBAL, BJ WELLFORD, LA MOODY, JM TI CHANGING PRESENTATION OF CORONARY HEART-DISEASE IN AN INPATIENT POPULATION WITHIN THE UNITED-STATES MILITARY HEALTH-CARE SYSTEM SO MILITARY MEDICINE LA English DT Article AB This study examines the changing presentation of coronary heart disease (CHD) in an inpatient population at Brooke Army Medical Center. The specific objectives of the study were to examine the presentation of CHD in a population unbiased by diagnosis-related group (DRG) reimbursements and to assess the importance of unstable angina and prior history of disease in the presentation of CHD. One thousand fifteen discharges in 1985 and 1,304 discharges in 1990 with the diagnosis of CHD were reviewed by cardiologists for evidence of symptomatic heart disease at the time of hospitalization. Forty percent of these charts were accepted into this study. The presentation rates of CHD were 1% with sudden death, 26% with myocardial infarction, 64% with angina, and 9% with congestive heart failure (CHF). During the study period, stable angina, Q-wave infarctions, and the myocardial infarction case fatality rate decreased (p < 0.05) and CHF and non-Q wave infarcts increased (p < 0.001). However, unstable angina was the most common presentation of CHD, and differences (p < 0.05) were noted in the presentation of CHD in patients with and without a prior history of disease. This study demonstrates the significance of unstable angina and prior history of CHD in an environment free of bias from DRG reimbursements. RP WELLFORD, L (reprint author), BROOKE ARMY MED CTR,DEPT MED,CARDIOL SERV,FT SAM HOUSTON,TX 78234, USA. NR 0 TC 10 Z9 10 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD SEP PY 1993 VL 158 IS 9 BP 598 EP 603 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA LX041 UT WOS:A1993LX04100010 PM 8232997 ER PT J AU CATTERSON, ML ZADOO, V AF CATTERSON, ML ZADOO, V TI PREVALENCE OF ASYMPTOMATIC CHLAMYDIAL CERVICAL INFECTION IN ACTIVE-DUTY ARMY FEMALES SO MILITARY MEDICINE LA English DT Article AB Four hundred seventy-six consecutive active duty Army females who presented for routine pap smears were screened for Chlamydia trachomatis and Neisseria gonorrhea. Thirty-nine of 476 (8.2%) tested positive for chlamydia using the Chlamydiazyme enzyme immunoassay. All patients with positive tests for chhamydia were asymptomatic and had normal pelvic exams. The average age of patients testing positive for chlamydia was 23.9. Only 6 of the 39 patients with chlamydia were older than 30. Tests for gonorrhea and pap smear results had little correlation with patients testing positive for chlamydia. The high prevalence of chlamydia in this population of asymptomatic women makes it probable that screening similar populations of patients would be more cost-effective than treating the complications of this disease. RP CATTERSON, ML (reprint author), TROOP MED CLIN 1,DIV INFANTRY 25,SCHOFIELD BARRACKS,HI, USA. NR 0 TC 11 Z9 12 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD SEP PY 1993 VL 158 IS 9 BP 618 EP 619 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA LX041 UT WOS:A1993LX04100015 PM 8233002 ER PT J AU SARNECKY, MT AF SARNECKY, MT TI INVENTING NURSING RESEARCH SO NURSING RESEARCH LA English DT Article RP SARNECKY, MT (reprint author), WALTER REED ARMY MED CTR,WASHINGTON,DC 20307, USA. NR 4 TC 3 Z9 3 U1 0 U2 2 PU AMER J NURSING CO PI NEW YORK PA 555 W 57TH ST, NEW YORK, NY 10019-2961 SN 0029-6562 J9 NURS RES JI Nurs. Res. PD SEP-OCT PY 1993 VL 42 IS 5 BP 318 EP 319 DI 10.1097/00006199-199309000-00018 PG 2 WC Nursing SC Nursing GA MD479 UT WOS:A1993MD47900018 PM 8415052 ER PT J AU DUREE, GC SHULTZ, JL BEI, NY SALAMO, GJ SHARP, EJ WOOD, GL MONTGOMERY, S NEURGAONKAR, RR AF DUREE, GC SHULTZ, JL BEI, NY SALAMO, GJ SHARP, EJ WOOD, GL MONTGOMERY, S NEURGAONKAR, RR TI ENHANCING THE PHOTOREFRACTIVE EFFECT SO OPTICS COMMUNICATIONS LA English DT Article ID TIME AB The transient response for beam fanning in photorefractive tungsten bronze crystals with an applied electric field and a focused laser beam is studied. Response times on the order of 1 ms for an incident power of 1 mW observed for incident beams focused to a 30 mum diameter in the crystal. This improved response time is accomplished without the significant reduction in the magnitude of the photorefractive effect normally observed for focused beams. C1 USA,RES LAB,FT BELVOIR,VA 22060. USN ACAD,ANNAPOLIS,MD 21402. ROCKWELL INT CORP,CTR SCI,THOUSAND OAKS,CA 91360. RP DUREE, GC (reprint author), UNIV ARKANSAS,DEPT PHYS,FAYETTEVILLE,AR 72701, USA. NR 9 TC 1 Z9 1 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0030-4018 J9 OPT COMMUN JI Opt. Commun. PD SEP 1 PY 1993 VL 101 IS 5-6 BP 397 EP 402 DI 10.1016/0030-4018(93)90737-P PG 6 WC Optics SC Optics GA LU631 UT WOS:A1993LU63100021 ER PT J AU LIVERMORE, GH KRYZER, TC PATOW, CA AF LIVERMORE, GH KRYZER, TC PATOW, CA TI ANEURYSM OF THE THORACIC-DUCT PRESENTING AS AN ASYMPTOMATIC LEFT SUPRACLAVICULAR NECK MASS SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY LA English DT Note ID MANAGEMENT; CHYLOTHORAX; FISTULA C1 WALTER REED ARMY MED CTR,OTOLARYNGOL HEAD & NECK SURG SERV,WASHINGTON,DC 20307. RP LIVERMORE, GH (reprint author), WINN ARMY COMMUNITY HOSP,OTOLARYNGOL HEAD & NECK SURG SERV,FT STEWART,GA 31314, USA. NR 17 TC 15 Z9 15 U1 0 U2 1 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0194-5998 J9 OTOLARYNG HEAD NECK JI Otolaryngol. Head Neck Surg. PD SEP PY 1993 VL 109 IS 3 BP 530 EP 533 PN 1 PG 4 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA MA889 UT WOS:A1993MA88900023 PM 8414574 ER PT J AU MONTEMARANO, AD JAMES, WD AF MONTEMARANO, AD JAMES, WD TI STAPHYLOCOCCUS-AUREUS AS A CAUSE OF PERIANAL DERMATITIS SO PEDIATRIC DERMATOLOGY LA English DT Note AB Perianal dermatitis has been reported to be caused by group A beta-hemolytic Streptococcus. We present a case caused by Staphylococcus aureus. A clinical clue pointing to this organism was the presence of satellite pustules. Identifying the pathogen in perianal dermatitis is therapeutically important, as oral penicillin VK will not be effective if S. aureus is the true cause. Other streptococcal and staphylococcal cutaneous infections may exhibit overlapping clinical features, including scarlet fever, impetigo, toxic shock syndrome, and cellulitis. RP MONTEMARANO, AD (reprint author), WALTER REED ARMY MED CTR,DERMATOL SERV,WASHINGTON,DC 20307, USA. NR 0 TC 20 Z9 20 U1 0 U2 0 PU BLACKWELL SCIENCE INC PI CAMBRIDGE PA 238 MAIN ST, CAMBRIDGE, MA 02142 SN 0736-8046 J9 PEDIATR DERMATOL JI Pediatr. Dermatol. PD SEP PY 1993 VL 10 IS 3 BP 259 EP 262 DI 10.1111/j.1525-1470.1993.tb00372.x PG 4 WC Dermatology; Pediatrics SC Dermatology; Pediatrics GA LX438 UT WOS:A1993LX43800010 PM 8415304 ER PT J AU CURTIS, J ONEILL, JT PETTETT, G AF CURTIS, J ONEILL, JT PETTETT, G TI ENDOTRACHEAL ADMINISTRATION OF TOLAZOLINE IN HYPOXIA-INDUCED PULMONARY-HYPERTENSION SO PEDIATRICS LA English DT Article DE TOLAZOLINE; MEAN PULMONARY ARTERY PRESSURE; PERSISTENT PULMONARY HYPERTENSION OF THE NEWBORN; HYPOXIA; PULMONARY VASCULAR RESISTANCE; SYSTEMIC VASCULAR RESISTANCE ID NEWBORN LAMBS; NITRIC-OXIDE; BLOOD-FLOW; ARTERIAL AB Study objective. To compare the pulmonary and systemic vascular responses to intravenously (IV) and endotracheally (ET) administered tolazoline (Tz) in newborn lambs with hypoxia-induced pulmonary hypertension. Design. Randomized, controlled study design. Methods. Twenty lambs, 2 to 7 days of age, were anesthetized, intubated, and surgically catheterized for continuous physiologic monitoring and cardiac output measurements using radiolabeled microspheres. After a postoperative stabilization period, the lambs were ventilated with a hypoxic gas mixture which was titrated to increase mean pulmonary artery pressure (MPAP) 30% to 50% above baseline. Each animal was randomly assigned to receive either IV-Tz (2 mg/kg), ET-Tz (4 mg/kg), or ET-saline (Sal, control group). Results. ET-Tz significantly (P < .05) reduced MPAP, PVRI (pulmonary vascular resistance index), MPAP/mean artery pressure (MAP) and PVRI/systemic vascular resistance index (SVRI), but not SVRI. IV-Tz lowered (P < .05) MPAP, PVRI, and PVRI/SVRI but also produced significant reductions in MAP and SVRI while only transiently decreasing MPAP/MAP. MPAP/MAP and PVRI/SVRI ratios were consistently lower in the ET-Tz animals than either the IV-Tz or ET-Sal animals. Conclusions. Our results suggest that ET-Tz produced a more selective pulmonary vascular response than IV-Tz and may warrant further investigation for potential clinical applications. C1 UNIFORMED SERV UNIV HLTH SCI,DEPT PEDIAT,NEONATAL MED SECT,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,DEPT PEDIAT,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. NR 34 TC 16 Z9 16 U1 0 U2 0 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD, ELK GROVE VILLAGE, IL 60007-1098 SN 0031-4005 J9 PEDIATRICS JI Pediatrics PD SEP PY 1993 VL 92 IS 3 BP 403 EP 408 PG 6 WC Pediatrics SC Pediatrics GA LV815 UT WOS:A1993LV81500009 PM 8361793 ER PT J AU GRAFF, LH USERY, EL AF GRAFF, LH USERY, EL TI AUTOMATED CLASSIFICATION OF GENERIC TERRAIN FEATURES IN DIGITAL ELEVATION MODELS SO PHOTOGRAMMETRIC ENGINEERING AND REMOTE SENSING LA English DT Article AB Using digital elevation models (DEMs), it is possible to automatically replicate the manual classification of elevated terrain features, or mounts, in certain physiographic regions. Results of the automatic classification, which uses percent slope and critical point information, are compared to a manual classification of the same area using computer-generated synthetic stereo images. Success of the automated classification appears to be limited by the algorithm, the nature of the regional terrain, and the quality of available digital elevation data. However, regional and local knowledge about the area may improve the classification results. C1 UNIV WISCONSIN,DEPT GEOG,MADISON,WI 53706. RP GRAFF, LH (reprint author), USA,CTR TOPOG ENGN,RES INST,CUDE BLDG 2592,FT BELVOIR,VA 22060, USA. NR 28 TC 23 Z9 23 U1 0 U2 0 PU AMER SOC PHOTOGRAMMETRY PI BETHESDA PA 5410 GROSVENOR LANE SUITE 210, BETHESDA, MD 20814-2160 SN 0099-1112 J9 PHOTOGRAMM ENG REM S JI Photogramm. Eng. Remote Sens. PD SEP PY 1993 VL 59 IS 9 BP 1409 EP 1417 PG 9 WC Geography, Physical; Geosciences, Multidisciplinary; Remote Sensing; Imaging Science & Photographic Technology SC Physical Geography; Geology; Remote Sensing; Imaging Science & Photographic Technology GA MA681 UT WOS:A1993MA68100006 ER PT J AU MOSER, J MATYSKA, C YUEN, DA MALEVSKY, AV HARDER, H AF MOSER, J MATYSKA, C YUEN, DA MALEVSKY, AV HARDER, H TI MANTLE RHEOLOGY, CONVECTION AND ROTATIONAL-DYNAMICS SO PHYSICS OF THE EARTH AND PLANETARY INTERIORS LA English DT Article ID POLAR WANDER; THERMAL-CONVECTION; SUBDUCTION; ANOMALIES; EARTH; BOUNDARY; MOTIONS; TIME; CORE AB We have examined theoretically the effects of mantle convection on Earth rotational dynamics for both viscoelastic and viscous mantles. Strategies for numerical computations are proposed. A linear Maxwell viscoelastic rheology accounting for finite deformations associated with mantle convection is considered. For both rheologies the two sets of convection and rotational equations can be partitioned into separate systems with the output from convection being used as input for the rotational equations. The differences in this convection-rotational problem between finite-strain and small-amplitude viscoelastic theories are delineated. An algorithm based on the usage of massively parallel processors is proposed in which all of the different processes in the convection-rotational problem are partitioned and the different timescales can be dealt with together. The coupled systems of convective-rotational equations can greatly be simplified by using the hydrostatic approximation for the rotational readjustment process in a viscous Earth model. This is valid for a young Earth and for non-Newtonian rheology. More contributions to the relative angular momentum can be expected from non-Newtonian rheology. The non-hydrostatic equatorial bulge may also be explained as a consequence of the long-wavelength dynamics associated with the effects of depth-dependent physical properties on mantle convection. C1 UNIV MINNESOTA,DEPT GEOL & GEOPHYS,ARMY HIGH PERFORMANCE COMP RES CTR,MINNEAPOLIS,MN 55455. UNIV MINNESOTA,MINNESOTA SUPERCOMP INST,MINNEAPOLIS,MN 55455. MAX PLANCK INST CHEM,W-6500 MAINZ,GERMANY. RP MOSER, J (reprint author), CHARLES UNIV,FAC MATH & PHYS,DEPT GEOPHYS,V HOLESOVICKACH 2,CS-18000 PRAGUE 8,CZECHOSLOVAKIA. RI Matyska, Ctirad/P-5807-2016 OI Matyska, Ctirad/0000-0002-2425-6540 NR 44 TC 9 Z9 9 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0031-9201 J9 PHYS EARTH PLANET IN JI Phys. Earth Planet. Inter. PD SEP PY 1993 VL 79 IS 3-4 BP 367 EP 381 DI 10.1016/0031-9201(93)90115-P PG 15 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA LX217 UT WOS:A1993LX21700006 ER PT J AU KANT, GJ BAUMAN, RA AF KANT, GJ BAUMAN, RA TI EFFECTS OF CHRONIC STRESS AND TIME OF DAY ON PREFERENCE FOR SUCROSE SO PHYSIOLOGY & BEHAVIOR LA English DT Article; Proceedings Paper CT 1ST CONF OF THE INTERNATIONAL BEHAVIORAL NEUROSCIENCE SOC CY MAY 21-24, 1992 CL SAN ANTONIO, TX SP INT BEHAV NEUROSCI SOC, AMER CYANAMID, CORTEX PHARM, GLAXO, PFIZER, SAN DIEGO INSTRUMENTS DE STRESS; EATING; CIRCADIAN RHYTHM; SUCROSE; CARBOHYDRATE ID RAT; HABITUATION; DEPRESSION; INCREASES; RESPONSES; BINDING; SHOCK AB Rats were allowed to lever press for two types of food pellets of equivalent caloric value and total carbohydrate content. One type of food pellet provided more of the calories as sucrose. During a 16-day prestress period, lever presses for 12 rats were recorded hourly. Following the baseline period, four rats (stressed group) were shaped to pull a ceiling chain to avoid or escape signalled foot shock presented intermittently around-the-clock. Four additional rats (yoked group) were each paired to one of the chain-pulling rats such that the rat trained to pull the ceiling chain controlled stressor termination for both rats. A third group of four rats served as the control group and received no shock. We have previously reported that rats in this model of chronic stress tolerate the paradigm well, continuing to gain weight, eat, drink water, and groom and escape more than 99% of the trials presented. During the baseline period, the sweeter pellet was preferred by most rats, but differences in preference among rats and in preference at different times of day were observed. The preference for the high-sucrose pellet was most marked in the hours preceding lights off. Overall, no changes in food preference were seen as a function of stress condition during the 14-day stress period, although one rat in the yoked group increased preference for the sweeter pellet during stress and returned to prestress food preferences when stress was terminated. RP KANT, GJ (reprint author), WALTER REED ARMY INST RES,DEPT MED NEUROSCI,WASHINGTON,DC 20307, USA. NR 24 TC 24 Z9 24 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0031-9384 J9 PHYSIOL BEHAV JI Physiol. Behav. PD SEP PY 1993 VL 54 IS 3 BP 499 EP 502 DI 10.1016/0031-9384(93)90242-8 PG 4 WC Psychology, Biological; Behavioral Sciences SC Psychology; Behavioral Sciences GA LT513 UT WOS:A1993LT51300014 PM 8415943 ER PT J AU LAURIE, CD AF LAURIE, CD TI BLACK GAMES, SUBVERSION, AND DIRTY TRICKS - THE OSS MORALE OPERATIONS BRANCH IN EUROPE, 1943-1945 SO PROLOGUE-QUARTERLY OF THE NATIONAL ARCHIVES LA English DT Article RP LAURIE, CD (reprint author), USA,CTR MIL HIST,WASHINGTON,DC 20310, USA. NR 37 TC 0 Z9 0 U1 0 U2 0 PU NATL ARCHIVES TRUST FUND BOARD PI WASHINGTON PA WASHINGTON, DC 20408 SN 0033-1031 J9 PROLOGUE JI Prologue-Q. Natl. Archives PD FAL PY 1993 VL 25 IS 3 BP 258 EP 271 PG 14 WC History SC History GA LV020 UT WOS:A1993LV02000005 ER PT J AU PENETAR, D MCCANN, U THORNE, D KAMIMORI, G GALINSKI, C SING, H THOMAS, M BELENKY, G AF PENETAR, D MCCANN, U THORNE, D KAMIMORI, G GALINSKI, C SING, H THOMAS, M BELENKY, G TI CAFFEINE REVERSAL OF SLEEP-DEPRIVATION EFFECTS ON ALERTNESS AND MOOD SO PSYCHOPHARMACOLOGY LA English DT Article DE HUMANS; CAFFEINE; STIMULANT; SLEEP DEPRIVATION; PROFILE OF MOOD STATES; VISUAL ANALOG SCALES; SERUM CONCENTRATION ID DAYTIME SLEEPINESS; D-AMPHETAMINE; PERFORMANCE; HUMANS; COFFEE; THEOPHYLLINE; WAKEFULNESS; VOLUNTEERS; DIAZEPAM; MEMORY AB This study assessed the ability of high doses of caffeine to reverse changes in alertness and mood produced by prolonged sleep deprivation. Fifty healthy, nonsmoking males between the ages of 18 and 32 served as volunteers. Following 49 h without sleep, caffeine (0, 150, 300, or 600 mg/70 kg, PO) was administered in a double-blind fashion. Measures of alertness were obtained with sleep-onset tests, the Stanford Sleepiness Scale (SSS), and Visual Analog Scales (VAS). Sleep deprivation decreased onset to sleep from a rested average of 19.9 min to 7 min. Following the highest dose of caffeine tested, sleep onset averaged just over 10 min; sleep onset for the placebo group averaged 5 min. Scores on the SSS increased from a rested mean of 1.6-4.8 after sleep deprivation. Caffeine reduced this score to near rested values. Caffeine reversed sleep deprivation-induced changes in three subscales of the POMS (vigor, fatigue, and confusion) and produced values close to fully rested conditions on several VAS. Serum caffeine concentrations peaked 90 min after ingestion and remained elevated for 12 h. This study showed that caffeine was able to produce significant alerting and long-lasting beneficial mood effects in individuals deprived of sleep for 48 h. C1 WALTER REED ARMY INST RES,DEPT BEHAV BIOL,WASHINGTON,DC 20307. NR 36 TC 110 Z9 112 U1 0 U2 10 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0033-3158 J9 PSYCHOPHARMACOLOGY JI Psychopharmacology PD SEP PY 1993 VL 112 IS 2-3 BP 359 EP 365 DI 10.1007/BF02244933 PG 7 WC Neurosciences; Pharmacology & Pharmacy; Psychiatry SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry GA LW907 UT WOS:A1993LW90700028 PM 7871042 ER PT J AU MCMANIS, SE BROWN, GR ZACHARY, R RUNDELL, JR AF MCMANIS, SE BROWN, GR ZACHARY, R RUNDELL, JR TI A SCREENING-TEST FOR SUBTLE COGNITIVE IMPAIRMENT EARLY IN THE COURSE OF HIV-INFECTION SO PSYCHOSOMATICS LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; MULTICENTER AIDS COHORT; ASYMPTOMATIC INDIVIDUALS; NERVOUS-SYSTEM; INVOLVEMENT; PREVALENCE; DEMENTIA; COMPLEX AB The authors report on the use of the Rey-Osterrieth Complex Figure Copy (ROC) and Memory (ROM) test as a bedside screening measure of cognitive impairment in 67 HIV-seropositive persons (43 men, 24 women). HIV-seropositive individuals scored significantly worse than 49 HIV-seronegative matched individuals (33 men, 16 women) in the control group on the ROC (P = 0.045, effect size = 0.39), but not on the ROM test. The scores did not correlate with stage of HIV infection, CD4a cell counts, cerebrospinal fluid parameters, or measures of affective state. No gender effects on performance were noted. It is concluded that while cognitive deficits may occur early in asymptomatic HIV disease, the ROC/ROM test as the authors used it is not a useful screening tool for clinicians. The study also suggests that the growing number of HIV-positive women should be included in neuropsychological studies of early HIV disease. C1 WILFORD HALL USAF MED CTR,LACKLAND AFB,TX 78236. WALTER REED ARMY INST RES,TRISERV HIV RES PROGRAM,WASHINGTON,DC 20307. NR 44 TC 4 Z9 4 U1 0 U2 0 PU AMER PSYCHIATRIC ASSOCIATION PI WASHINGTON PA 1400 K ST NW, WASHINGTON, DC 20005 SN 0033-3182 J9 PSYCHOSOMATICS JI Psychosomatics PD SEP-OCT PY 1993 VL 34 IS 5 BP 424 EP 431 PG 8 WC Psychiatry; Psychology SC Psychiatry; Psychology GA LU809 UT WOS:A1993LU80900007 PM 8140192 ER PT J AU BIRK, A MCQUAID, MJ BLIESENER, GG AF BIRK, A MCQUAID, MJ BLIESENER, GG TI A PARTICLE BED HEATER FOR CREATING A CLEAR, HIGH-TEMPERATURE, HIGH-PRESSURE GAS-FLOW SO REVIEW OF SCIENTIFIC INSTRUMENTS LA English DT Article AB The design and operation of a compact, lightweight particle bed heater for rapidly loading (less-than-or-equal-to 1 s) a 1000 cm 3 test chamber with clear, high-temperature (100 less-than-or-equal-to T less-than-or-equal-to 600-degrees-C), high-pressure (10 less-than-or-equal-to P less-than-or-equal-to 50 MPa) gas is described. rhe device facilitates the design of short duration (less-than-or-equal-to 10 s) experiments where visualization of dynamic systems at such conditions are desired. The heater has enabled visualization of reactive spray phenomena in our laboratory, and its performance in this application is summarized. RP BIRK, A (reprint author), USA,RES LAB,AMSRL-WT-PA,ABERDEEN PROVING GROUND,MD 21005, USA. NR 7 TC 1 Z9 1 U1 0 U2 1 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0034-6748 J9 REV SCI INSTRUM JI Rev. Sci. Instrum. PD SEP PY 1993 VL 64 IS 9 BP 2673 EP 2675 DI 10.1063/1.1143889 PG 3 WC Instruments & Instrumentation; Physics, Applied SC Instruments & Instrumentation; Physics GA LX891 UT WOS:A1993LX89100046 ER PT J AU JOHNSON, AR STACER, RG AF JOHNSON, AR STACER, RG TI RUBBER VISCOELASTICITY USING THE PHYSICALLY CONSTRAINED SYSTEMS STRETCHES AS INTERNAL VARIABLES SO RUBBER CHEMISTRY AND TECHNOLOGY LA English DT Article; Proceedings Paper CT 142ND MEETING ( FALL 92 ) OF THE RUBBER-DIVISION OF THE AMERICAN-CHEMICAL-SOC CY NOV 03-06, 1992 CL NASHVILLE, TN SP AMER CHEM SOC, RUBBER DIV ID MODEL AB The simulation of rubber viscoelasticity with the tube reptation model for topological interactions is investigated for large dynamic strains. The chemically crosslinked (CC) system of molecules acts as a constraint box per unit volume for the physically constrained (PC) system and carries the PC system during the deformation process. A stick-slip model is used to simulate the interaction between the CC and PC systems. Stretch ratios describe the history of the PC system's energy. Rubber energy density functions for both the CC and time dependent PC systems are shown to model large strain viscoelastic deformations. In this approach the energy is split into two terms. The long term energy function for the CC molecules represents one part and a time dependent energy function for the PC molecules comprises the second part. The PC systems' stretches then appear as internal variables in the expression of the total energy. The relaxation of the PC molecules during a general deformation is determined by the history of the CC system's strain state and the box (tube) stick-slip relaxation equation(s). Examples are presented in which step-strain relaxation test data and strain rate data are simulated for large deformations of a rubber compound with differing short and long term energy functions. C1 USA,MAT TECHNOL LAB,WATERTOWN,MA 02172. NR 15 TC 28 Z9 28 U1 0 U2 0 PU AMER CHEMICAL SOC INC PI AKRON PA RUBBER DIV UNIV AKRON PO BOX 499, AKRON, OH 44309-0499 SN 0035-9475 J9 RUBBER CHEM TECHNOL JI Rubber Chem. Technol. PD SEP-OCT PY 1993 VL 66 IS 4 BP 567 EP 577 DI 10.5254/1.3538329 PG 11 WC Polymer Science SC Polymer Science GA MB663 UT WOS:A1993MB66300007 ER PT J AU QUIGLEY, CJ DOOLEY, R PARKS, DM AF QUIGLEY, CJ DOOLEY, R PARKS, DM TI AN EXPERIMENTAL-STUDY OF FAILURE IN CIRCUMFERENTIALLY NOTCHED ELASTOMER CYLINDERS SO RUBBER CHEMISTRY AND TECHNOLOGY LA English DT Article; Proceedings Paper CT 142ND MEETING ( FALL 92 ) OF THE RUBBER-DIVISION OF THE AMERICAN-CHEMICAL-SOC CY NOV 03-06, 1992 CL NASHVILLE, TN SP AMER CHEM SOC, RUBBER DIV ID TEARING ENERGY; CAVITATION; FRACTURE AB Cylindrical dumbbell specimens containing deep circumferential cracks were loaded in tension until failure to investigate the fracture process in thick carbon black filled elastomers. Failure occurred at large deformations and was characterized by material tearing and small amounts of slow stable crack extension until rupture. The tearing process itself consisted of two distinct phenomena, delamination and crack extension. Upon load application, parabolic and asymmetric blunting of the crack tip was observed followed by a visible separation of the fabricated crack surfaces into upper and lower crack surfaces connected by an inner core of elastomer material. Localized material failure, identified as delamination, occurred along the outer surface of this inner core between the fabricated crack surfaces. Crack extension in the load direction was found above and below the fabricated crack surfaces. Both qualitative and quantitative aspects of failure were studied. Load and crack mouth opening displacement (CMOD) histories were examined, and the stretch ratio and tearing energy at rupture were measured. Finally, a model describing the tearing process was discussed. C1 MIT,CAMBRIDGE,MA 02139. RP QUIGLEY, CJ (reprint author), USA,RES LAB,WATERTOWN,MA 02172, USA. NR 21 TC 0 Z9 0 U1 0 U2 2 PU AMER CHEMICAL SOC INC PI AKRON PA RUBBER DIV UNIV AKRON PO BOX 499, AKRON, OH 44309-0499 SN 0035-9475 J9 RUBBER CHEM TECHNOL JI Rubber Chem. Technol. PD SEP-OCT PY 1993 VL 66 IS 4 BP 646 EP 663 DI 10.5254/1.3538336 PG 18 WC Polymer Science SC Polymer Science GA MB663 UT WOS:A1993MB66300014 ER PT J AU LANDE, RG AF LANDE, RG TI UNTITLED - REPLY SO SUICIDE AND LIFE-THREATENING BEHAVIOR LA English DT Letter RP LANDE, RG (reprint author), WALTER REED ARMY MED CTR,WASHINGTON,DC 20307, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU GUILFORD PUBLICATIONS INC PI NEW YORK PA 72 SPRING STREET, NEW YORK, NY 10012 SN 0363-0234 J9 SUICIDE LIFE-THREAT JI Suicide Life-Threat. Behav. PD FAL PY 1993 VL 23 IS 3 BP 283 EP 283 PG 1 WC Psychiatry; Psychology, Multidisciplinary SC Psychiatry; Psychology GA NT387 UT WOS:A1993NT38700022 ER PT J AU BYRON, JW MARKENSON, G MIYAZAWA, K AF BYRON, JW MARKENSON, G MIYAZAWA, K TI A RANDOMIZED COMPARISON OF VERRES NEEDLE AND DIRECT TROCAR INSERTION FOR LAPAROSCOPY SO SURGERY GYNECOLOGY & OBSTETRICS LA English DT Article ID PRIOR PNEUMOPERITONEUM AB Two hundred and fifty-two women scheduled to undergo laparoscopy were randomly assigned to a Verres needle or direct insertion group. The groups were similar with respect to incidence of obesity, prior surgical treatment, indication for operation and level of training of the surgeon performing the procedure. There were no major complications associated with either technique. Minor complications (preperitoneal insufflation, failed entry or more than three attempts necessary to enter the peritoneal cavity with the trocar) were significantly more frequent (p<0.05) in the Verres needle technique group. One hundred and thirteen of these patients underwent sterilization procedures. The mean times for performance of the laparoscopic procedure using die direct insertion and Verres needle techniques were 15.3 and 19.6 minutes, respectively. The time saved using die direct insertion technique is explained by a significant (p<0.01) reduction in die mean laparoscope insertion time, which was 2.2 minutes and 5.9 minutes for the direct insertion and Verres needle techniques, respectively. We prefer die direct insertion technique for trocar placement because it has fewer minor complications and requires less operating time. C1 TRIPLER ARMY MED CTR,HONOLULU,HI 96859. NR 11 TC 83 Z9 85 U1 0 U2 2 PU FRANKLIN H MARTIN FOUNDATION PI CHICAGO PA 55 E ERIE ST, CHICAGO, IL 60611 SN 0039-6087 J9 SURG GYNECOL OBSTET JI Surg. Gynecol. Obstet. PD SEP PY 1993 VL 177 IS 3 BP 259 EP 262 PG 4 WC Obstetrics & Gynecology; Surgery SC Obstetrics & Gynecology; Surgery GA LW406 UT WOS:A1993LW40600009 PM 8356499 ER PT J AU JOHNSON, ED GONZALEZ, JP GEORGES, A AF JOHNSON, ED GONZALEZ, JP GEORGES, A TI HEMORRHAGIC-FEVER VIRUS ACTIVITY IN EQUATORIAL AFRICA - DISTRIBUTION AND PREVALENCE OF FILOVIRUS REACTIVE ANTIBODY IN THE CENTRAL-AFRICAN-REPUBLIC SO TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID EBOLA VIRUS; LASSA AB Seroepidemiological surveys were conducted to determine the frequency and distribution of haemorrhagic fever virus (HFV) activity in the Central African Republic. Human serum specimens (4295) were collected from 5 ecologically distinct zones. Serological evidence of HFV activity was found in all the zones. The filovirus antibody prevalence (24.4%, 1051/4295) was greater than the combined prevalence for Lassa virus, Rift Valley fever virus and Crimean-Congo HFV antibody (1.1%, 45/4295; P<0.01). Evidence of filovirus activity was found in all zones: 21.3% (914/4295) of the population were seropositive for Ebola virus antibody while only 3.2% (137/4295) were seroreactive with Marburg viral antigens. Age and sex were important host-related factors influencing filovirus activity, particularly in dry grassland and moist forest communities. These communities shared many factors, but differences, such as agricultural practices and ethnic backgrounds, may also affect the risk of infection. Filovirus infections appear to occur without apparent disease. Continued investigations are needed to evaluate the true pathogenicity of the African filoviruses and the likelihood that unidentified serologically cross-reacting and non-pathogenic members of the filovirus family are active in equatorial Africa. C1 INST FRANCAIS RECH SCI DEV COOPERAT, PARIS, FRANCE. INST PASTEUR, BANGUI, CENT AFR REPUBL. RP JOHNSON, ED (reprint author), USA, MED RES INST INFECT DIS, FREDERICK, MD 21701 USA. NR 29 TC 26 Z9 28 U1 0 U2 9 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0035-9203 EI 1878-3503 J9 T ROY SOC TROP MED H JI Trans. Roy. Soc. Trop. Med. Hyg. PD SEP-OCT PY 1993 VL 87 IS 5 BP 530 EP 535 DI 10.1016/0035-9203(93)90075-2 PG 6 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA ME375 UT WOS:A1993ME37500010 PM 8266402 ER PT J AU JOHNSON, ED GONZALEZ, JP GEORGES, A AF JOHNSON, ED GONZALEZ, JP GEORGES, A TI FILOVIRUS ACTIVITY AMONG SELECTED ETHNIC-GROUPS INHABITING THE TROPICAL FOREST OF EQUATORIAL AFRICA SO TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID HEMORRHAGIC-FEVER VIRUSES; ANTIBODIES AB Seroepidemiological surveys were conducted to determine the frequency and distribution of filovirus activity among selected ethnic groups inhabiting the tropical forests of the Central African Republic. 427 serum specimens were collected from hunter-gatherers and subsistence farmers living in forest environs in the Lobaye District south of the river Lobaye and west of the river Oubangui. Striking serological evidence for filovirus activity was found in both populations. Ebola virus appears to be the most active filovirus; 17.6% (75/427) of the Lobaye survey population were seropositive for Ebola virus reactive antibody while 1.2% (5/427) were seroreactive with Marburg viral antigens. Ethnic background appeared to be an important risk factor influencing filovirus exposure in the forest communities. The filovirus antibody prevalence among 21-40 years old male Aka Pygmy hunter-gatherers was significantly (P=0.03) 3 times higher (37.5%) than that in similarly aged male Monzombo and Mbati subsistence farmers (13.2%). Continued epidemiological investigations are needed to define ethnic-related events influencing human filovirus activity in the Congo basin of equatorial Africa. C1 INST PASTEUR, BANGUI, CENT AFR REPUBL. ORSTOM, INST FRANCAIS RECH SCI DEV COOPERAT, PARIS, FRANCE. RP JOHNSON, ED (reprint author), USA, MED RES INST INFECT DIS, FREDERICK, MD 21701 USA. OI Gonzalez, Jean-Paul/0000-0003-3063-1770 NR 20 TC 37 Z9 39 U1 0 U2 6 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0035-9203 EI 1878-3503 J9 T ROY SOC TROP MED H JI Trans. Roy. Soc. Trop. Med. Hyg. PD SEP-OCT PY 1993 VL 87 IS 5 BP 536 EP 538 DI 10.1016/0035-9203(93)90077-4 PG 3 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA ME375 UT WOS:A1993ME37500011 PM 8266403 ER PT J AU MEBRAHTU, YB VANEYS, G GUIZANI, I LAWYER, PG PAMBA, H KOECH, D ROBERTS, C PERKINS, PV WERE, JB HENDRICKS, LD AF MEBRAHTU, YB VANEYS, G GUIZANI, I LAWYER, PG PAMBA, H KOECH, D ROBERTS, C PERKINS, PV WERE, JB HENDRICKS, LD TI HUMAN CUTANEOUS LEISHMANIASIS CAUSED BY LEISHMANIA-DONOVANI SL IN KENYA SO TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID OLD-WORLD; TROPICA; IDENTIFICATION; ELECTROPHORESIS; ZYMODEMES AB Our laboratory is characterizing Leishmania stabilates and isolates from active leishmaniasis cases. Smears and cultures from aspirates made on different dates from a single lesion on the bridge of the nose of an 18 years old Kenyan male from Nyandarua District contained Leishmania. The isolates, NLB-271 and NLB-271-IA, were characterized by cellulose acetate electrophoresis (CAE) using 20 enzyme systems and by Southern analysis using 2 deoxyribonucleic acid (DNA) probes (pDK10 and pDK20) from a Dakar strain of L. major (MHOM/SN/00/DK1) and a third probe, p7-059 from L. infantum strain ITMAP-263. Digestion of the two Leishmania DNAs with endonucleases HindIII and PstI, followed by hybridization with the 3 probes, revealed DNA fragment banding patterns indistinguishable from those of the L. donovani species complex. The CAE isoenzyme profiles of these 2 Kenyan isolates were indistinguishable from those of Kenyan L. donovani strains we designated as zymodeme Z6. Excluding post-kala-azar dermal leishmaniasis, this constitutes the first human case of cutaneous leishmaniasis caused by L. donovani s.l. in Kenya. Previously, cutaneous leishmaniasis cases in Kenya have been due to L. aethiopica, L. major and L. tropica only. C1 USA,MED RES UNIT KENYA,BOX 30137,NAIROBI,KENYA. KENYA GOVT MED RES CTR,NAIROBI,KENYA. INST PASTEUR TUNIS,TUNIS 1002,TUNISIA. WALTER REED ARMY INST RES,DEPT ENTOMOL,WASHINGTON,DC 20307. UNIV NAIROBI,FAC MED,NAIROBI,KENYA. ROYAL TROP INST,AMSTERDAM,NETHERLANDS. NR 15 TC 21 Z9 21 U1 0 U2 0 PU ROYAL SOC TROPICAL MEDICINE PI LONDON PA MANSON HOUSE 26 PORTLAND PLACE, LONDON, ENGLAND W1N 4EY SN 0035-9203 J9 T ROY SOC TROP MED H JI Trans. Roy. Soc. Trop. Med. Hyg. PD SEP-OCT PY 1993 VL 87 IS 5 BP 598 EP 601 DI 10.1016/0035-9203(93)90101-U PG 4 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA ME375 UT WOS:A1993ME37500030 PM 8266420 ER PT J AU LADWIG, M GIANGERUSO, E REID, T AF LADWIG, M GIANGERUSO, E REID, T TI THE EFFECT OF SUBCUTANEOUS ANTI-RH(0)(D) IN ADULT PATIENTS WITH IMMUNE THROMBOCYTOPENIC PURPURA SO TRANSFUSION LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. WALTER REED ARMY INST RES,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC BLOOD BANKS PI BETHESDA PA 8101 GLENBROOK RD, BETHESDA, MD 20814-2749 SN 0041-1132 J9 TRANSFUSION JI Transfusion PD SEP PY 1993 VL 33 IS 9 SU S BP S61 EP S61 PG 1 WC Hematology SC Hematology GA LZ447 UT WOS:A1993LZ44700236 ER PT J AU WHITE, JC SHAVER, TR KOCANDRLE, V AF WHITE, JC SHAVER, TR KOCANDRLE, V TI SIMULTANEOUS KIDNEY-PANCREAS TRANSPLANTATION USING A HORSESHOE KIDNEY SO TRANSPLANT INTERNATIONAL LA English DT Letter C1 WALTER REED ARMY MED CTR,DEPT SURG,ORGAN TRANSPLANT SERV,6825 GEORGIA AVE NW,WASHINGTON,DC 20307. NR 0 TC 6 Z9 7 U1 0 U2 0 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0934-0874 J9 TRANSPLANT INT JI Transpl. Int. PD SEP PY 1993 VL 6 IS 5 BP 302 EP 303 DI 10.1007/BF00336034 PG 2 WC Surgery; Transplantation SC Surgery; Transplantation GA LU950 UT WOS:A1993LU95000013 PM 8216711 ER PT J AU BOUDREAU, E SCHUSTER, B SANCHEZ, J NOVAKOWSKI, W JOHNSON, R REDMOND, D HANSON, R DAUSEL, L AF BOUDREAU, E SCHUSTER, B SANCHEZ, J NOVAKOWSKI, W JOHNSON, R REDMOND, D HANSON, R DAUSEL, L TI TOLERABILITY OF PROPHYLACTIC LARIAM(R) REGIMENS SO TROPICAL MEDICINE AND PARASITOLOGY LA English DT Article; Proceedings Paper CT SYMP ON MALARIA AND TRAVEL - PRACTICAL ASPECTS, AT THE 3RD CONF ON INTERNATIONAL TRAVEL MEDICINE CY APR, 1993 CL PARIS, FRANCE ID FALCIPARUM-MALARIA; ACUTE-PSYCHOSIS; MEFLOQUINE; DOXYCYCLINE; SYMPTOMS; EFFICACY AB Three hundred and fifty-nine US Marines participated in a randomized double-blind clinical trial to assess tolerance of two prophylactic mefloquine regimens [250 mg salt weekly (n = 157) or 250 mg daily for 3 days followed by 250 mg weekly (n = 46)] compared with 300 mg weekly chloroquine (n = 156) over a 12-week period. The study participants were seen daily for four days, then weekly for 11 weeks. On each visit, the subject answered two computerized questionnaires (a review of body systems and an evaluation of mood states), participated in a physician interview, and was administered medications under supervision. A random sample of each group was assigned to either pharmacokinetic sampling or to wear a wrist watch size computerized sleep monitor (actigraph). The frequencies of intercurrent illness and other concomitant medications were tabulated. End study mefloquine plasma levels were obtained on all study participants. The results obtained showed no compromise in function due to dizziness or incoordination in the mefloquine groups. Overall, both weekly mefloquine and loading dose mefloquine were well tolerated. Sleep disturbance and increased dream activity were detected in the mefloquine groups. Depressive feelings were noted in two to three times more individuals in the mefloquine groups than in the chloroquine group early in the course of the study, and resolved in the majority of subjects as tolerance developed. Steady state mefloquine plasma levels were attained rapidly with the loading dose regimen in four days versus seven weeks with weekly mefloquine. The mefloquine loading dose regimen should be considered as an option for short-term adult travelers or military personnel to chloroquine-resistant areas of the world. C1 WALTER REED ARMY INST RES,WASHINGTON,DC 20307. USA,ENVIRONM MED RES INST,NATICK,MA 01760. USN,HONOLULU,HI. RP BOUDREAU, E (reprint author), PHARMACEUT SYST INC,927 B N RUSSELL AVE,GAITHERSBURG,MD 20879, USA. NR 26 TC 69 Z9 69 U1 0 U2 0 PU GEORG THIEME VERLAG PI STUTTGART PA P O BOX 30 11 20, D-70451 STUTTGART, GERMANY SN 0177-2392 J9 TROP MED PARASITOL JI Trop. Med. Parasitol. PD SEP PY 1993 VL 44 IS 3 BP 257 EP 265 PG 9 WC Parasitology; Tropical Medicine SC Parasitology; Tropical Medicine GA MD343 UT WOS:A1993MD34300023 PM 8256107 ER PT J AU MOREY, AF DESHON, GE ROZANSKI, TA DRESNER, ML AF MOREY, AF DESHON, GE ROZANSKI, TA DRESNER, ML TI TECHNIQUE OF BIOPTY GUN TESTIS NEEDLE-BIOPSY SO UROLOGY LA English DT Article C1 TRIPLER ARMY MED CTR,DEPT SURG,UROL SERV,HONOLULU,HI 96859. NR 2 TC 5 Z9 6 U1 0 U2 0 PU CAHNERS PUBL CO PI NEW YORK PA 249 WEST 17 STREET, NEW YORK, NY 10011 SN 0090-4295 J9 UROLOGY JI UROLOGY PD SEP PY 1993 VL 42 IS 3 BP 325 EP 326 DI 10.1016/0090-4295(93)90625-K PG 2 WC Urology & Nephrology SC Urology & Nephrology GA LX672 UT WOS:A1993LX67200017 PM 8379035 ER PT J AU LIVINGSTON, PO CALVES, MJ HELLING, F ZOLLINGER, WD BLAKE, MS LOWELL, GH AF LIVINGSTON, PO CALVES, MJ HELLING, F ZOLLINGER, WD BLAKE, MS LOWELL, GH TI GD3/PROTEOSOME VACCINES INDUCE CONSISTENT IGM ANTIBODIES AGAINST THE GANGLIOSIDE GD3 SO VACCINE LA English DT Article DE PROTEOSOMES; ANTIGEN-DELIVERY SYSTEM; GANGLIOSIDES; TUMOR ID PURIFIED GM2 GANGLIOSIDE; MALIGNANT-MELANOMA; PHASE-I; IMMUNIZATION; MOUSE; IMMUNOGENICITY; PEPTIDES; LACTONES; ELICIT; CELLS AB The gangliosides of melanoma and other tumours of neuroectodermal origin are suitable targets for immune intervention with tumour vaccines. The optimal vaccines in current use contain ganglioside plus bacillus Calmette-Guerin and induce considerable morbidity. We have screened a variety of new adjuvants in the mouse, and describe one antigen-delivery system, proteosomes, which is especially effective. Highly hydrophobic Neisserial outer membrane proteins (OMP) form multimolecular liposome-like vesicular structures termed proteosomes which can readily incorporate amphiphilic molecules such as GD3 ganglioside. The optimal GD3/proteosome vaccine formulation for induction of GD3 antibodies in the mouse is determined. Interestingly, the use of potent immunological adjuvants in addition to proteosomes augments the IgM and IgG antibody titres against OMP in these vaccines but GD3 antibody titres are unaffected. The application of proteosomes to enhance the immune response to GD3 extends the concept of the proteosome immunopotentiating system from lipopeptides to amphipathic carbohydrate epitopes such as cell-surface gangliosides. The demonstrated safety of meningococcal OMP in humans and the data in mice presented here suggest that proteosome vaccines have potential for augmenting the immunogenicity of amphipathic tumour antigens in humans. C1 WALTER REED ARMY INST RES,WASHINGTON,DC 20307. ROCKEFELLER UNIV,NEW YORK,NY 10021. RP LIVINGSTON, PO (reprint author), MEM SLOAN KETTERING CANC CTR,NEW YORK,NY 10021, USA. FU NCI NIH HHS [CA 40532] NR 25 TC 41 Z9 42 U1 0 U2 1 PU BUTTERWORTH-HEINEMANN LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB SN 0264-410X J9 VACCINE JI Vaccine PD SEP PY 1993 VL 11 IS 12 BP 1199 EP 1204 DI 10.1016/0264-410X(93)90043-W PG 6 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA LZ908 UT WOS:A1993LZ90800005 PM 8256501 ER PT J AU HASE, T AF HASE, T TI VIRUS-NEURON INTERACTIONS IN THE MOUSE-BRAIN INFECTED WITH JAPANESE ENCEPHALITIS-VIRUS SO VIRCHOWS ARCHIV B-CELL PATHOLOGY INCLUDING MOLECULAR PATHOLOGY LA English DT Article DE GOLGI APPARATUS; JAPANESE ENCEPHALITIS VIRUS; MOUSE BRAIN NEURON; ROUGH ENDOPLASMIC RETICULUM; VIRAL INFECTION ID NUCLEOTIDE-SEQUENCE; MOSQUITO CELLS; MATURATION; LIGHT AB The virus-host interactions between Japanese encephalitis (JE) virus and mouse brain neurons were analyzed by electron microscopy. JE virus replicated exclusively in the rough endoplasmic reticulum (RER) of neurons. In the early phase of infection, the perikaryon of infected neurons had relatively normal-looking lamellar RER whose cisternae showed focal dilations containing progeny virions and characteristic endoplasmic reticulum (ER) vesicles. The reticular RER, consisted of rows of ribosomes surrounding irregular-shaped, membrane-unbounded cisternae and resembled that observed in JE-virus-infected PC12 cells, were also seen adjacent to the lamellar RER. The appearance of the reticular RER indicated that RER morphogenesis occurred in infected neurons in association with the viral replication. The fine network of Golgi apparatus was extensively obliterated by fragmentation and dissolution of the Golgi membranes and their replacement by the electron-lucent material. As the infection progressed, the lamellar RER was increasingly replaced by the hypertrophic RER which had diffusely dilated cisternae containing multiple progeny virions and ER vesicles. The Golgi apparatus, at this stage, was seen as coarse, localized Golgi complexes near the hypertrophic RER. In the later phase of infection, RER of infected neurons showed a degenerative change, with the cystically dilated cisternae being filled with ER vesicles and virions. Small, localized Golgi complexes frequently showed vesiculation, vacuolation, and dispersion. The present study, therefore, indicated that during the viral replication the normal lamellar RER which synthesized neuronal secretory and membrane proteins was replaced by the hypertrophic RER which synthesized the viral proteins. The hypertrophic RER eventually degenerated into cystic RER whose cisternae were filled with viral products. The constant degenerative change which occurred in the Golgi apparatus during the viral replication suggested that some of the viral proteins transported from RER to the Golgi apparatus were harmful to the Golgi apparatus and that increasing damage to the Golgi apparatus during the viral replication played the principal role in the pathogenesis of JE-virus-infected neurons in the central nervous system. RP HASE, T (reprint author), WALTER REED ARMY INST RES,DIV PATHOL,DEPT ULTRASTRUCT PATHOL,WASHINGTON,DC 20307, USA. NR 13 TC 12 Z9 13 U1 0 U2 0 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0340-6075 J9 VIRCHOWS ARCH B JI Virchows Arch. B-Cell Molec. Pathol. PD SEP PY 1993 VL 64 IS 3 BP 161 EP 170 DI 10.1007/BF02915109 PG 10 WC Pathology SC Pathology GA LY392 UT WOS:A1993LY39200005 PM 8242175 ER PT J AU ALOJ, SM LIGUORO, D KIANG, JG SMALLRIDGE, RC AF ALOJ, SM LIGUORO, D KIANG, JG SMALLRIDGE, RC TI PURINERGIC (P(2)) RECEPTOR-OPERATED CALCIUM-ENTRY INTO RAT-THYROID CELLS SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS LA English DT Article ID PAROTID ACINAR-CELLS; EXTRACELLULAR ATP; PHOSPHOINOSITIDE METABOLISM; SIGNAL TRANSDUCTION; PHOSPHOLIPASE-C; HEPATOCYTES; INCREASE; CA-2+; P2-PURINOCEPTOR; PERMEABILITY C1 WALTER REED ARMY INST RES,DIV MED,DEPT CLIN PHYSIOL,WASHINGTON,DC 20307. NR 27 TC 14 Z9 14 U1 0 U2 1 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0006-291X J9 BIOCHEM BIOPH RES CO JI Biochem. Biophys. Res. Commun. PD AUG 31 PY 1993 VL 195 IS 1 BP 1 EP 7 DI 10.1006/bbrc.1993.2000 PG 7 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA LU459 UT WOS:A1993LU45900001 PM 8363591 ER PT J AU SALOMON, M AF SALOMON, M TI ALKALI-METAL PLUS MACROCYCLIC LIGAND COMPLEXES IN A 36-MASS-PERCENT MIXTURE OF PROPYLENE CARBONATE IN DICHLOROMETHANE SO JOURNAL OF ELECTROANALYTICAL CHEMISTRY LA English DT Article ID ELECTROLYTES; CONDUCTIVITY; 18-CROWN-6; SOLUBILITY; IONS AB Conductivity data are reported for LiClO4, LiAsF6, NaClO4, NaBPh4, KSCN and n-tetrabutylammonium perchlorate in a mixed, solvent containing 36 mass% propylene carbonate in dichloromethane at 25-degrees-C. For the alkali metal salts, the formation constants K(f) for complexation with the crown ether 18C6 and the cryptand 222 were also determined by the conductivity method. Single ion molar conductivities were estimated using the assumption lambda-degrees-(n-Bu4N+) = lambda-degrees-(BPh4-). Treatment of the data in terms of the Fuoss-Hsia equation shows that ion association between the cation + macrocyclic ligand and the anion cannot be ignored. The magnitudes of K(f) and lambda-degrees are discussed in terms of ion-solvent interactions and conformational changes of the macrocyclic ligand upon complexation. RP SALOMON, M (reprint author), USA,ARL,DIV POWER SOURCES,FT MONMOUTH,NJ 07703, USA. NR 26 TC 9 Z9 9 U1 0 U2 1 PU ELSEVIER SCIENCE SA LAUSANNE PI LAUSANNE 1 PA PO BOX 564, 1001 LAUSANNE 1, SWITZERLAND SN 0022-0728 J9 J ELECTROANAL CHEM JI J. Electroanal. Chem. PD AUG 30 PY 1993 VL 355 IS 1-2 BP 265 EP 276 DI 10.1016/0022-0728(93)80367-Q PG 12 WC Chemistry, Analytical; Electrochemistry SC Chemistry; Electrochemistry GA LV153 UT WOS:A1993LV15300017 ER EF