FN Thomson Reuters Web of Science™ VR 1.0 PT J AU CARTER, JM WASSEF, N ALVING, CR DOCTOR, BP AF CARTER, JM WASSEF, N ALVING, CR DOCTOR, BP TI FUNCTIONAL SPECIFICITY OF PEPTIDES DERIVED FROM THE RIM REGION OF FETAL BOVINE SERUM ACETYLCHOLINESTERASE SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,DIV BIOCHEM,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD APR 20 PY 1993 VL 7 IS 7 BP A1236 EP A1236 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA KY848 UT WOS:A1993KY84801150 ER PT J AU CHIANG, PK BROWN, N BUTLER, D NAUSS, J XIAO, W CARTER, JM AF CHIANG, PK BROWN, N BUTLER, D NAUSS, J XIAO, W CARTER, JM TI CHARACTERIZATION OF SOLUTION STRUCTURES AND BIOLOGICAL EFFECTS OF A SERIES OF THYMOPENTIN ANALOGS SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,DIV BIOCHEM,WASHINGTON,DC 20307. WALTER REED ARMY INST RES,DIV MED,WASHINGTON,DC 20307. NIDDK,BETHESDA,MD 20810. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD APR 20 PY 1993 VL 7 IS 7 BP A1236 EP A1236 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA KY848 UT WOS:A1993KY84801148 ER PT J AU GORDON, RK ZENG, GC GARCIA, GE BRUGH, SA ESTRADA, JS CHIANG, PK AF GORDON, RK ZENG, GC GARCIA, GE BRUGH, SA ESTRADA, JS CHIANG, PK TI CHOLERA-TOXIN (CTX), BUT NOT PERTUSSIS TOXIN (PTX), MODULATES SERUM STIMULATED C-FOS EXPRESSION IN TRANSFECTED 3T3-L1-CELLS SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,DIV BIOCHEM,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD APR 20 PY 1993 VL 7 IS 7 BP A1233 EP A1233 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA KY848 UT WOS:A1993KY84801130 ER PT J AU GUAN, E OCKENHOUSE, CF MIGLIORINI, M GREENWALT, D AF GUAN, E OCKENHOUSE, CF MIGLIORINI, M GREENWALT, D TI STRUCTURE-FUNCTION STUDIES OF CD36 RELATIVE TO SEQUESTRATION OF PLASMODIUM-FALCIPARUM INFECTED RED-BLOOD-CELLS (IRBC) SO FASEB JOURNAL LA English DT Meeting Abstract C1 AMER RED CROSS,DEPT CELL BIOL,ROCKVILLE,MD 20855. AMER RED CROSS,DEPT BIOCHEM,ROCKVILLE,MD 20855. WALTER REED ARMY INST RES,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD APR 20 PY 1993 VL 7 IS 7 BP A1243 EP A1243 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA KY848 UT WOS:A1993KY84801187 ER PT J AU JETT, M BOYLE, T GENIS, P WELCH, C BERNTON, E GENDELMAN, HE AF JETT, M BOYLE, T GENIS, P WELCH, C BERNTON, E GENDELMAN, HE TI DEVELOPMENT OF TECHNIQUES TO SEPARATE, IDENTIFY AND QUANTITATE GREATER-THAN-30 ARACHIDONATE METABOLITES AND PAF IN SMALL SAMPLES - APPLICATION TO A MODEL OF HIV-INDUCED DEMENTIA SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,DIV PATHOL,WASHINGTON,DC 20307. UNIV NEBRASKA,MED CTR,OMAHA,NE 68105. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD APR 20 PY 1993 VL 7 IS 7 BP A1257 EP A1257 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA KY848 UT WOS:A1993KY84801271 ER PT J AU MCGRATH, KP DIGIROLAMO, CM KAPLAN, DL AF MCGRATH, KP DIGIROLAMO, CM KAPLAN, DL TI PROTEIN-PROTEIN RECOGNITION IN SYNTHETIC LEUCINE ZIPPERS SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,NATICK RD&E CTR,DIV BIOTECHNOL,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD APR 20 PY 1993 VL 7 IS 7 BP A1280 EP A1280 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA KY848 UT WOS:A1993KY84801408 ER PT J AU SAXENA, A ASHANI, Y PANG, Y YAMADA, F KOZIKOWSKI, AP DOCTOR, BP AF SAXENA, A ASHANI, Y PANG, Y YAMADA, F KOZIKOWSKI, AP DOCTOR, BP TI INHIBITION OF CHOLINESTERASES BY STEREOISOMERS OF HUPERZINE-A SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,WASHINGTON,DC 20307. MAYO CLIN,JACKSONVILLE,FL 32224. NR 0 TC 1 Z9 1 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD APR 20 PY 1993 VL 7 IS 7 BP A1077 EP A1077 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA KY848 UT WOS:A1993KY84800224 ER PT J AU TRAN, U BOYLE, T JETT, M AF TRAN, U BOYLE, T JETT, M TI STAPHYLOCOCCAL ENTEROTOXIN-B (SEB) INHIBITION OF AGGREGATION AND ADHESION IN HUMAN THROMBOCYTES - ACTIVATION OF PROTEIN-KINASE-C AND ARACHIDONATE METABOLISM SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,DIV PATHOL,WASHINGTON,DC 20307. NR 0 TC 1 Z9 1 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD APR 20 PY 1993 VL 7 IS 7 BP A1234 EP A1234 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA KY848 UT WOS:A1993KY84801138 ER PT J AU MICKEVICIUS, R MITIN, V STROSCIO, MA DUTTA, M AF MICKEVICIUS, R MITIN, V STROSCIO, MA DUTTA, M TI NEGATIVE ABSOLUTE CONDUCTIVITY IN QUANTUM WIRES SO APPLIED PHYSICS LETTERS LA English DT Article ID SEMICONDUCTOR AB The effect of negative absolute conductivity in quasi-one-dimensional quantum wire structures is obtained by the Monte Carlo simulation. This negative conductivity is associated with inelastic optical phonon scattering leading to an asymmetric electron distribution function established under conditions of intensive electron photoinjection. Simulation results suggest that quantum wires are ideal for the experimental observation of negative absolute conductivity. The oscillations of photoconductivity as a function of injection energy can reveal the spectrum of optical phonons in quantum wires which differs considerably from that in bulk materials. C1 USA,RES OFF,RES TRIANGLE PK,NC 27709. USA,SLCET,ED,ELECTR TECHNOL & DEVICES LAB,FT MONMOUTH,NJ 07703. RP MICKEVICIUS, R (reprint author), WAYNE STATE UNIV,DEPT ELECT & COMP ENGN,DETROIT,MI 48202, USA. NR 9 TC 2 Z9 2 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD APR 19 PY 1993 VL 62 IS 16 BP 1970 EP 1972 PG 3 WC Physics, Applied SC Physics GA KX554 UT WOS:A1993KX55400039 ER PT J AU SANCHEZ, JL DEFRAITES, RF SHARP, TW HANSON, RK AF SANCHEZ, JL DEFRAITES, RF SHARP, TW HANSON, RK TI MEFLOQUINE OR DOXYCYCLINE PROPHYLAXIS IN UNITED-STATES TROOPS IN SOMALIA SO LANCET LA English DT Letter ID MALARIA C1 USN,MED RES INST,BETHESDA,MD 20814. USN,ENVIRONM & PREVENT MED UNIT 6,HONOLULU,HI. RP SANCHEZ, JL (reprint author), WALTER REED ARMY INST RES,DIV PREVENT MED,WASHINGTON,DC 20307, USA. NR 7 TC 36 Z9 36 U1 0 U2 1 PU LANCET LTD PI LONDON PA 42 BEDFORD SQUARE, LONDON, ENGLAND WC1B 3SL SN 0140-6736 J9 LANCET JI Lancet PD APR 17 PY 1993 VL 341 IS 8851 BP 1021 EP 1022 DI 10.1016/0140-6736(93)91107-W PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA KY368 UT WOS:A1993KY36800030 PM 8096898 ER PT J AU MURPHY, GS BODHIDATTA, L ECHEVERRIA, P TANSUPHASWADIKUL, S HOGE, CW IMLARP, S TAMURA, K AF MURPHY, GS BODHIDATTA, L ECHEVERRIA, P TANSUPHASWADIKUL, S HOGE, CW IMLARP, S TAMURA, K TI CIPROFLOXACIN AND LOPERAMIDE IN THE TREATMENT OF BACILLARY DYSENTERY SO ANNALS OF INTERNAL MEDICINE LA English DT Article DE DYSENTERY, BACILLARY; CIPROFLOXACIN; LOPERAMIDE; DIARRHEA; SHIGELLA-DYSENTERIAE ID ESCHERICHIA-COLI; TRAVELERS DIARRHEA; STOOL SPECIMENS; TRIMETHOPRIM; SHIGELLOSIS; CHILDREN; THERAPY; DISEASE; TRIAL AB Objective: To compare the safety and efficacy of loperamide plus ciprofloxacin with those of ciprofloxacin alone in the treatment of bacillary dysentery. Design: Double-blind, placebo-controlled, randomized clinical trial. Setting: Hospital in Thailand. Participants: Eighty-eight adults with dysentery seeking medical care between November 1990 and February 1992. Patients who had received prior antibiotics or antimotility drugs were excluded. Intervention: All 88 patients with dysentery were treated with ciprofloxacin, 500 mg twice daily for 3 days. Forty-two of these patients were randomly assigned to receive loperamide, a 4-mg initial dose followed by 2 mg after every loose stool (as many as eight caplets [16 mg] daily), and 46 were randomly assigned to receive placebo. Measurements: Stools were collected daily until resolution of diarrhea and again after 10 days. The time to passage of the last unformed stool, number of unformed stools, and symptoms were recorded after treatment. Results: Shigella or enteroinvasive Escherichia coli (53%), Vibrio parahaemolyticus (16%), and Salmonella (7%) were the most common bacterial enteric pathogens identified in 88 patients with dysentery. In patients infected with Shigella or enteroinvasive E. coli, the median duration of diarrhea was 19 hours (25th to 75th percentiles, 6 to 42 hours) for those receiving loperamide plus ciprofloxacin compared with 42 hours (21 to 46 hours) for those receiving ciprofloxacin alone (P = 0.028). The median number of diarrheal stools for those receiving ciprofloxacin and loperamide was 2.0 (1 to 5 stools) compared with 6.5 (2 to 9 stools) for those receiving ciprofloxacin alone (P = 0.016). None of the participants had a temperature greater than 38-degrees-C after 24 hours of treatment. None of the patients was infected with the same bacterial enteric pathogen more than 1 day after receiving treatment. Conclusions: Loperamide decreases the number of unformed stools and shortens the duration of diarrhea in dysentery caused by Shigella in adults treated with ciprofloxacin. C1 NATL INST HLTH,TOKYO 141,JAPAN. ARMED FORCES RES INST MED SCI,BANGKOK,THAILAND. BAMRASNARADURA HOSP,NONTHABURI,THAILAND. ARMY INST CLIN PATHOL,BANGKOK,THAILAND. NR 31 TC 54 Z9 54 U1 0 U2 2 PU AMER COLL PHYSICIANS PI PHILADELPHIA PA INDEPENDENCE MALL WEST 6TH AND RACE ST, PHILADELPHIA, PA 19106-1572 SN 0003-4819 J9 ANN INTERN MED JI Ann. Intern. Med. PD APR 15 PY 1993 VL 118 IS 8 BP 582 EP 586 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA KW470 UT WOS:A1993KW47000002 PM 8452323 ER PT J AU SAU, P LUPTON, GP GRAHAM, JH AF SAU, P LUPTON, GP GRAHAM, JH TI PILOMATRIX CARCINOMA SO CANCER LA English DT Article DE PILOMATRIXOMA; PILOMATRIX CARCINOMA; BASALOID CELLS; SHADOW CELLS; CLEAR CELLS ID CALCIFYING EPITHELIOMA AB Background. Pilomatrix carcinoma, a malignant variant of pilomatrixoma, is extremely rare. The authors report 20 patients with pilomatrix carcinoma and review the pertinent literature. Methods. Tumors showing histologic features of pilomatrix carcinoma were selected from the files of the Armed Forces Institute of Pathology. Clinical data of the 20 selected patients were reviewed, and follow-up information was obtained. Sections stained with hematoxylin and eosin were studied in all patients. Special stains were used in selected patients. Results. Pilomatrix carcinomas were asymptomatic dermal and subcutaneous masses with a predilection for the posterior neck and back. Tumors varied in size, from 1-10 cm (mean, 4.6 cm), and occurred more often in middle-age men, with a male:female ratio of 4:1 (mean age, 45 years). Histologically, pilomatrix carcinomas are characterized by sheets and islands of proliferating atypical basaloid cells with an infiltrating border. Transition to squamous cells, clear cells, areas of necrosis and mitoses often are seen. Keratinization with formation of keratin cysts, shadow cells, and trichohyalin and keratohyalin granules are found in all tumors, in conjunction with calcification and foreign body giant cell reaction, just as are seen in benign pilomatrixoma. Follow-up of 17 patients revealed local recurrence in 10 (59%), with multiple recurrences in 3. One patient had pulmonary metastasis, and one died of extensive local spread of the tumor. Conclusion. Pilomatrix carcinomas are locally aggressive tumors that have a tendency to recur, especially when they are incompletely excised. Greater anaplasia and deep soft tissue infiltration were associated with a higher incidence of recurrence and death. Wide excision is the preferred treatment. The role of radiation therapy is unclear. C1 ARMED FORCES INST PATHOL,DEPT DERMATOPATHOL,WASHINGTON,DC 20306. SCRIPPS CLIN & RES FDN,DEPT PATHOL,DIV DERMATOPATHOL,LA JOLLA,CA 92037. RP SAU, P (reprint author), WALTER REED ARMY MED CTR,DEPT DERMATOL & PATHOL,DERMATOL SERV,WASHINGTON,DC 20307, USA. NR 28 TC 63 Z9 64 U1 0 U2 1 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0008-543X J9 CANCER JI Cancer PD APR 15 PY 1993 VL 71 IS 8 BP 2491 EP 2498 DI 10.1002/1097-0142(19930415)71:8<2491::AID-CNCR2820710811>3.0.CO;2-I PG 8 WC Oncology SC Oncology GA KW562 UT WOS:A1993KW56200010 PM 8453573 ER PT J AU SHANMUGARATNAM, K SOBIN, LH AF SHANMUGARATNAM, K SOBIN, LH TI THE WORLD-HEALTH-ORGANIZATION HISTOLOGICAL CLASSIFICATION OF TUMORS OF THE UPPER RESPIRATORY-TRACT AND EAR - A COMMENTARY ON THE 2ND EDITION SO CANCER LA English DT Note DE CLASSIFICATION; TUMORS; NASAL CAVITY AND SINUSES; NASOPHARYNX; LARYNX; HYPOPHARYNX; TRACHEA; EAR ID UPPER AERODIGESTIVE TRACT; LETHAL MIDLINE GRANULOMA; SPINDLE-CELL-CARCINOMA; MIDDLE-EAR; ADENOMA; TUMORS; PAPILLOMAS; LARYNX; HEAD; NECK AB The second edition of Histological Typing of Tumours of the Upper Respiratory Tract and Ear, in the World Health Organization series International Histological Classification of Tumours, provides a comprehensive classification of tumors and tumor-like lesions occurring in (1) the nasal cavity and paranasal sinuses; (2) the nasopharynx; (3) the larynx, hypopharynx, and trachea; (4) the external ear; and (5) the middle and inner ear. The classification includes several newly recognized entities and many that were omitted from the first edition on account of their rarity. The terminology and definitions of several tumor types have been revised in the light of experience gained during the past 12 years. This article discusses the revised classification with special reference to some of the major changes in the listings, terminology, and definitions. C1 NATL UNIV SINGAPORE,DEPT PATHOL,SINGAPORE 0511,SINGAPORE. USA,INST PATHOL,WASHINGTON,DC 20310. NR 40 TC 104 Z9 112 U1 0 U2 2 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0008-543X J9 CANCER JI Cancer PD APR 15 PY 1993 VL 71 IS 8 BP 2689 EP 2697 DI 10.1002/1097-0142(19930415)71:8<2689::AID-CNCR2820710843>3.0.CO;2-H PG 9 WC Oncology SC Oncology GA KW562 UT WOS:A1993KW56200041 PM 8453591 ER PT J AU WEIR, JP MELTZER, MS AF WEIR, JP MELTZER, MS TI TRANSFECTION OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 PROVIRAL DNA INTO PRIMARY HUMAN MONOCYTES SO CELLULAR IMMUNOLOGY LA English DT Article ID GENE-EXPRESSION; MONONUCLEAR PHAGOCYTES; INFECTION; HIV-1; LYMPHOCYTES; MACROPHAGE; TROPISM; IDENTIFICATION; DETERMINANT; REGIONS C1 WALTER REED ARMY INST RES,DEPT CELLULAR IMMUNOL,WASHINGTON,DC 20307. WALTER REED ARMY INST RES,HENRY M JACKSON FDN ADVANCEMENT MIL MED,WASHINGTON,DC 20307. NR 22 TC 13 Z9 13 U1 0 U2 2 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0008-8749 J9 CELL IMMUNOL JI Cell. Immunol. PD APR 15 PY 1993 VL 148 IS 1 BP 157 EP 165 DI 10.1006/cimm.1993.1098 PG 9 WC Cell Biology; Immunology SC Cell Biology; Immunology GA LB965 UT WOS:A1993LB96500013 PM 8495484 ER PT J AU BOROWSKI, R SAU, K REID, RH MCQUEEN, CE BOEDEKER, EC NELLORE, R DALAL, P BHAGAT, HR AF BOROWSKI, R SAU, K REID, RH MCQUEEN, CE BOEDEKER, EC NELLORE, R DALAL, P BHAGAT, HR TI INTRADUODENAL IMMUNIZATION WITH MICROENCAPSULATED CFA/II INDUCES A DELAYED, ANTI-CFA/II, IGG ANTIBODY-SECRETING SPLEEN-CELL RESPONSE SO JOURNAL OF IMMUNOLOGY LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,WASHINGTON,DC 20307. UNIV MARYLAND,SCH PHARM,BALTIMORE,MD 21202. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD APR 15 PY 1993 VL 150 IS 8 BP A36 EP A36 PN 2 PG 1 WC Immunology SC Immunology GA KX956 UT WOS:A1993KX95600197 ER PT J AU DROST, AC BURLESON, DG CIOFFI, WG MASON, AD PRUITT, BA AF DROST, AC BURLESON, DG CIOFFI, WG MASON, AD PRUITT, BA TI THE RELATIONSHIP OF PLASMA CYTOKINES TO INFECTION FOLLOWING THERMAL-INJURY SO JOURNAL OF IMMUNOLOGY LA English DT Meeting Abstract C1 USA,INST SURG RES,FT SAM HOUSTON,TX 78234. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD APR 15 PY 1993 VL 150 IS 8 BP A293 EP A293 PN 2 PG 1 WC Immunology SC Immunology GA KX956 UT WOS:A1993KX95601686 ER PT J AU KOPPENHEFFER, TL BURLESON, DG MASON, AD PRUITT, BA AF KOPPENHEFFER, TL BURLESON, DG MASON, AD PRUITT, BA TI UNIMPAIRED ANTIBODY-FORMING CELL CAPACITY IN SCALD-BURNED RATS SO JOURNAL OF IMMUNOLOGY LA English DT Meeting Abstract C1 TRINITY UNIV,SAN ANTONIO,TX 78212. USA,INST SURG RES,FT SAM HOUSTON,TX 78234. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD APR 15 PY 1993 VL 150 IS 8 BP A158 EP A158 PN 2 PG 1 WC Immunology SC Immunology GA KX956 UT WOS:A1993KX95600909 ER PT J AU NAUSS, JL REID, RH SADEGHNASSERI, S AF NAUSS, JL REID, RH SADEGHNASSERI, S TI BINDING INTERACTIONS OF PEPTIDES IN A STRUCTURAL HOMOLOGY MODEL OF THE DR1 CLASS-II MHC SO JOURNAL OF IMMUNOLOGY LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,DEPT GASTROENTEROL,WASHINGTON,DC 20307. NIAID,LI,BETHESDA,MD 20892. NR 2 TC 1 Z9 1 U1 0 U2 0 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD APR 15 PY 1993 VL 150 IS 8 BP A41 EP A41 PN 2 PG 1 WC Immunology SC Immunology GA KX956 UT WOS:A1993KX95600232 ER PT J AU REID, R BOEDEKER, E BHAGAT, H TACKET, C LOSONSKY, G NATARO, J EDELMAN, R LEVINE, M AF REID, R BOEDEKER, E BHAGAT, H TACKET, C LOSONSKY, G NATARO, J EDELMAN, R LEVINE, M TI COLONIZATION FACTOR ANTIGEN/II (CFA/II) INCORPORATED INTO BIODEGRADABLE, BIOCOMPATIBLE MICROSPHERES AS AN INTESTINAL VACCINE AGAINST ENTEROTOXIGENIC ESCHERICHIA-COLI (ETEC) - A SAFETY, IMMUNIZATION, AND EFFICACY HUMAN STUDY SO JOURNAL OF IMMUNOLOGY LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,WASHINGTON,DC 20307. UNIV MARYLAND,SCH PHARM,BALTIMORE,MD 21202. NR 0 TC 1 Z9 1 U1 0 U2 0 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD APR 15 PY 1993 VL 150 IS 8 BP A323 EP A323 PN 2 PG 1 WC Immunology SC Immunology GA KX956 UT WOS:A1993KX95601866 ER PT J AU SITZ, KV RATTO, S MANCA, F REDFIELD, RR BIRX, DL AF SITZ, KV RATTO, S MANCA, F REDFIELD, RR BIRX, DL TI PHENOTYPIC CHANGES DURING THE DEVELOPMENT OF GP160, GP120, AND TETANUS SPECIFIC T-LYMPHOCYTE LINES IN AN HIV SEROPOSITIVE PATIENT SO JOURNAL OF IMMUNOLOGY LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,DEPT RETROVIRAL RES,ROCKVILLE,MD 20850. HENRY M JACKSON FDN,ROCKVILLE,MD. UNIV GENOA,DEPT IMMUNOL,I-16126 GENOA,ITALY. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD APR 15 PY 1993 VL 150 IS 8 BP A103 EP A103 PN 2 PG 1 WC Immunology SC Immunology GA KX956 UT WOS:A1993KX95600586 ER PT J AU TALOR, E FUCCILLO, DA BIRX, DL FOWLER, AK AF TALOR, E FUCCILLO, DA BIRX, DL FOWLER, AK TI WHOLE-BLOOD CELL-PROLIFERATION IN HIV PATIENTS AND NORMAL CONTROLS SO JOURNAL OF IMMUNOLOGY LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,DIV RETROVIROL,DEPT RETROVIRAL RES,WASHINGTON,DC 20307. SRA TECHNOL INC,ROCKVILLE,MD 20850. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD APR 15 PY 1993 VL 150 IS 8 BP A327 EP A327 PN 2 PG 1 WC Immunology SC Immunology GA KX956 UT WOS:A1993KX95601888 ER PT J AU YAMAGA, KM WEIDA, AJ KIMURA, LH LANCE, EM AF YAMAGA, KM WEIDA, AJ KIMURA, LH LANCE, EM TI MURINE LYMPHOCYTE-PROLIFERATION INDUCED BY SYNGENEIC CHONDROCYTES SO JOURNAL OF IMMUNOLOGY LA English DT Meeting Abstract C1 UNIV HAWAII,SHRINERS HOSP CRIPPLED CHILDREN,JOHN A BURNS SCH MED,HONOLULU,HI 96826. TRIPLER ARMY MED CTR,HONOLULU,HI 96826. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD APR 15 PY 1993 VL 150 IS 8 BP A237 EP A237 PN 2 PG 1 WC Immunology SC Immunology GA KX956 UT WOS:A1993KX95601368 ER PT J AU CROCE, F PASSERINI, S SCROSATI, B PLICHTA, E BEHL, W SALOMON, M SCHLEICH, D AF CROCE, F PASSERINI, S SCROSATI, B PLICHTA, E BEHL, W SALOMON, M SCHLEICH, D TI THE LIXTIS2-VERTICAL-BAR-LI(1-X)COO2 SOLID-STATE ROCKING CHAIR BATTERY SO JOURNAL OF POWER SOURCES LA English DT Article; Proceedings Paper CT 6TH INTERNATIONAL MEETING ON LITHIUM BATTERIES CY MAY 10-15, 1992 CL MUNSTER, GERMANY ID METAL AB The present paper describes the fabrication and characterization of a novel type of a solid-state, thin-layer lithium rocking chair battery. The battery utilizes titanium disulfide, TiS2, as the negative 'lithium sink' electrode, lithium cobalt dioxide, LixCoO2, as the positive 'lithium source' electrode, and a composite lithium ion-conducting polymer membrane as the electrolyte. Our initial studies on this novel system involved characterization of the charge/discharge behaviour and a.c. impedance responses. C1 USA,ELECTRON & POWER SOURCES DIRECTORATE,ARL,DIV POWER SOURCES,FT MONMOUTH,NJ 07703. POLYTECH INST NEW YORK,DEPT CHEM,BROOKLYN,NY 11201. RP CROCE, F (reprint author), UNIV ROMA LA SAPIENZA,DIPARTIMENTO CHIM,I-00185 ROME,ITALY. RI Croce, Fausto/J-8193-2012; Passerini, Stefano/A-3859-2015 OI Passerini, Stefano/0000-0002-6606-5304 NR 11 TC 2 Z9 2 U1 1 U2 10 PU ELSEVIER SCIENCE SA LAUSANNE PI LAUSANNE 1 PA PO BOX 564, 1001 LAUSANNE 1, SWITZERLAND SN 0378-7753 J9 J POWER SOURCES JI J. Power Sources PD APR 15 PY 1993 VL 44 IS 1-3 BP 481 EP 484 DI 10.1016/0378-7753(93)80192-R PG 4 WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials Science, Multidisciplinary SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science GA LH764 UT WOS:A1993LH76400020 ER PT J AU WINSLOW, RL KIMBALL, AL VARGHESE, A NOBLE, D AF WINSLOW, RL KIMBALL, AL VARGHESE, A NOBLE, D TI SIMULATING CARDIAC SINUS AND ATRIAL NETWORK DYNAMICS ON THE CONNECTION MACHINE SO PHYSICA D LA English DT Article ID ELECTRICAL-ACTIVITY; RABBIT HEART; MATHEMATICAL-MODEL; SINOATRIAL NODE; PACEMAKER CELLS; MECHANISMS; CURRENTS; CALCIUM; SYNCHRONIZATION; RECONSTRUCTION AB Computational methods for simulating biophysically detailed, large-scale models of mammalian cardiac sinus and atrial networks on the massively parallel Connection Machine CM-2, and techniques for visualization of simulation data, are presented. Individual cells are modeled using the formulations of Noble et al. Models incorporate properties of voltage-dependent membrane currents, ion pumps and exchangers, and internal calcium sequestering and release mechanisms. Network models are used to investigate factors determining the site of generation and direction of propagation of the pacemaker potential. Models of the isolated sinus node are used to show that very few gap junction channels are required to support frequency entrainment. When cell membrane properties in the isolated sinus node models are modified to reproduce regional differences in oscillation properties, as described by the data of Kodama and Boyett, an excitatory wave is generated in the node periphery which propagates towards the node center. This agrees with activation patterns measured in the isolated sinus node by Kirchoff. When the model sinus node is surrounded by a region of atrial cells, the site of pacemaker potential generation is shifted away from the periphery towards the node center. This is in agreement with activation patterns measured by Kirchoff in the intact sinus node of the rabbit heart, and demonstrates the importance of sinus node boundary conditions on shaping the site of generation and direction of propagation of the pacemaker potential. C1 UNIV MINNESOTA,DEPT PHYSIOL,MINNEAPOLIS,MN 55455. UNIV MINNESOTA,USA,HIGH PERFORMANCE COMP RES CTR,MINNEAPOLIS,MN 55455. UNIV OXFORD,PHYSIOL LAB,OXFORD,ENGLAND. THINKING MACHINES CORP,CAMBRIDGE,MA 02142. NR 41 TC 73 Z9 73 U1 0 U2 4 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-2789 J9 PHYSICA D JI Physica D PD APR 15 PY 1993 VL 64 IS 1-3 BP 281 EP 298 DI 10.1016/0167-2789(93)90260-8 PG 18 WC Mathematics, Applied; Physics, Multidisciplinary; Physics, Mathematical SC Mathematics; Physics GA KY647 UT WOS:A1993KY64700014 ER PT J AU ALLEY, RB MEESE, DA SHUMAN, CA GOW, AJ TAYLOR, KC GROOTES, PM WHITE, JWC RAM, M WADDINGTON, ED MAYEWSKI, PA ZIELINSKI, GA AF ALLEY, RB MEESE, DA SHUMAN, CA GOW, AJ TAYLOR, KC GROOTES, PM WHITE, JWC RAM, M WADDINGTON, ED MAYEWSKI, PA ZIELINSKI, GA TI ABRUPT INCREASE IN GREENLAND SNOW ACCUMULATION AT THE END OF THE YOUNGER DRYAS EVENT SO NATURE LA English DT Article ID ICE CORES; CLIMATE; BP AB THE warming at the end of the last glaciation was characterized by a series of abrupt returns to glacial climate, the best-known of which is the Younger Dryas event1. Despite much study of the causes of this event and the mechanisms by which it ended, many questions remain unresolved1. Oxygen isotope data from Greenland ice cores2-4 suggest that the Younger Dryas ended abruptly, over a period of about 50 years; dust concentrations2,4 in these cores show an even more rapid transition (less-than-or-similar-to 20 years). This extremely short timescale places severe constraints on the mechanisms underlying the transition. But dust concentrations can reflect subtle changes in atmospheric circulation, which need not be associated with a large change in climate. Here we present results from a new Greenland ice core (GISP2) showing that snow accumulation doubled rapidly from the Younger Dryas event to the subsequent Preboreal interval, possibly in one to three years. We also find that the accumulation-rate change from the Oldest Dryas to the Bolling/Allerod warm period was large and abrupt. The extreme rapidity of these changes in a variable that directly represents regional climate implies that the events at the end of the last glaciation may have been responses to some kind of threshold or trigger in the North Atlantic climate system. C1 PENN STATE UNIV,DEPT GEOSCI,UNIV PK,PA 16802. USA,COLD REG RES & ENGN LAB,SNOW & ICE BRANCH,HANOVER,NH 03755. UNIV NEVADA,DESERT RES INST,RENO,NV 89506. UNIV WASHINGTON,QUATERNARY ISOTOPE LAB,SEATTLE,WA 98195. UNIV COLORADO,INST ARCTIC & ALPINE RES,BOULDER,CO 80309. UNIV BUFFALO,DEPT PHYS,AMHERST,NY 14260. UNIV WASHINGTON,GEOPHYS PROGRAM,SEATTLE,WA 98195. UNIV NEW HAMPSHIRE,INST STUDY EARTH OCEANS & SPACE,GLACIER RES GRP,DURHAM,NH 03824. RP ALLEY, RB (reprint author), PENN STATE UNIV,CTR EARTH SYST SCI,UNIV PK,PA 16802, USA. RI Grootes, Pieter/F-4952-2011; White, James/A-7845-2009; Taylor, Kendrick/A-3469-2016 OI White, James/0000-0001-6041-4684; Taylor, Kendrick/0000-0001-8535-1261 NR 27 TC 764 Z9 795 U1 12 U2 156 PU MACMILLAN MAGAZINES LTD PI LONDON PA PORTERS SOUTH, 4 CRINAN ST, LONDON, ENGLAND N1 9XW SN 0028-0836 J9 NATURE JI Nature PD APR 8 PY 1993 VL 362 IS 6420 BP 527 EP 529 DI 10.1038/362527a0 PG 3 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA KW453 UT WOS:A1993KW45300049 ER PT J AU HEPPNER, DG MAGILL, AJ GASSER, RA OSTER, CN AF HEPPNER, DG MAGILL, AJ GASSER, RA OSTER, CN TI THE THREAT OF INFECTIOUS-DISEASES IN SOMALIA SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Review ID JARISCH-HERXHEIMER REACTION; CRIMEAN HEMORRHAGIC-FEVER; BORNE RELAPSING FEVER; RENAL-TRANSPLANT RECIPIENTS; CHRONIC LIVER-DISEASE; PLASMODIUM-FALCIPARUM; TYPHOID-FEVER; DISSEMINATED HISTOPLASMOSIS; VISCERAL LEISHMANIASIS; UNITED-STATES C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 179 TC 11 Z9 11 U1 1 U2 2 PU MASS MEDICAL SOC PI BOSTON PA 10 SHATTUCK, BOSTON, MA 02115 SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD APR 8 PY 1993 VL 328 IS 14 BP 1061 EP 1068 DI 10.1056/NEJM199304083281430 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA KW282 UT WOS:A1993KW28200039 PM 8450874 ER PT J AU BLANEY, SM GREM, JL BALIS, FM COLE, DE ADAMSON, PC POPLACK, DG AF BLANEY, SM GREM, JL BALIS, FM COLE, DE ADAMSON, PC POPLACK, DG TI MECHANISM OF RESISTANCE TO CYCLOPENTENYL CYTOSINE (CPE-C) IN MOLT-4 LYMPHOBLASTS SO BIOCHEMICAL PHARMACOLOGY LA English DT Article ID CYTIDINE DEAMINASE; 1-BETA-D-ARABINOFURANOSYLCYTOSINE 5'-TRIPHOSPHATE; CTP SYNTHETASE; CELLS; TRIPHOSPHATE; LEUKEMIA; PHARMACOLOGY; QUANTITATION; PURIFICATION; INHIBITION AB Cyclopentenyl cytosine (CPE-C), a carbocyclic analogue of cytidine. has preclinical anti-neoplastic activity against ara-C resistant murine leukemias and a broad spectrum of human tumor xenografts. CPE-C is a prodrug and requires intracellular phosphorylation to cyclopentenyl cytosine triphosphate (CPE-CTP) which depletes endogenous CTP pools. The initial step in this activation process is catalyzed by uridine/cytidine kinase. We studied the mechanism of resistance to CPE-C in a Molt-4 T-cell leukemia line made resistant to CPE-C (Molt-4R) by culturing it in the continuous presence of increasing concentrations of CPE-C. Using a tetrazolium based colorimetric assay to assess cytotoxicity, the IC90 for the parent Molt-4 cells (Molt-4WT) was 0.5 muM after a 24 hr drug exposure. In contrast, cytotoxicity was not observed at concentrations as high as 1 mM in the Molt-4R cells. Following a brief exposure to 1 muM CPE-C, parent drug could be detected intracellularly in the resistant and sensitive cell lines. However, CPE-CTP formation was reduced markedly in the resistant cell line. Measurement of the activity of anabolic and catabolic enzymes in the Molt-4WT and Molt-4R cells revealed equivalent activities of alkaline and acid phosphatases as well as cytidine and dCMP deaminase but there was a significant reduction in uridine/cytidine kinase activity in Molt-4R cells. Endogenous ribonucleotide pools and CPE-CTP pools were measured in the absence and presence of CPE-C. CTP pools were reduced markedly in Molt-4WT cells following exposure to CPE-C. However, CTP pools in Molt-4R cells exposed to 100 muM CPE-C were two times greater than in the untreated Molt-4WT cells. At high concentrations of CPE-C (10 and 100 muM), Molt-4R cells were able to generate amounts of CPE-CTP equivalent to that seen in Molt-4WT cells exposed to 1 muM CPE-C (a cytotoxic concentration of drug in Molt-4WT cells), but no cytotoxic effect was seen in Molt-4R cells. Therefore, in addition to decreased uridine/cytidine kinase activity, a second mechanism of resistance that is the result of alterations in CTP synthetase activity also appears to be operative. Elucidation of the mechanism of resistance in vitro may provide insight into the mechanism of action of the drug and potential mechanisms of resistance in vivo. C1 WALTER REED ARMY MED CTR, WASHINGTON, DC 20307 USA. NATL NAVAL MED CTR, NCI, NAVY MED ONCOL BRANCH, BETHESDA, MD 20899 USA. RP BLANEY, SM (reprint author), NCI, PEDIAT BRANCH, BLDG 10, ROOM 13N240, 9000 ROCKVILLE PIKE, BETHESDA, MD 20892 USA. NR 26 TC 11 Z9 11 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0006-2952 J9 BIOCHEM PHARMACOL JI Biochem. Pharmacol. PD APR 6 PY 1993 VL 45 IS 7 BP 1493 EP 1501 DI 10.1016/0006-2952(93)90050-7 PG 9 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA KX573 UT WOS:A1993KX57300016 PM 8471071 ER PT J AU MICKEVICIUS, R MITIN, V STROSCIO, MA DUTTA, M AF MICKEVICIUS, R MITIN, V STROSCIO, MA DUTTA, M TI OSCILLATIONS OF PHOTOCONDUCTIVITY AND NEGATIVE ABSOLUTE CONDUCTIVITY IN QUANTUM WIRES SO JOURNAL OF PHYSICS-CONDENSED MATTER LA English DT Article ID OPTICAL-PHONON-SCATTERING; RADIATION; GERMANIUM AB The phenomenon of oscillating photoconductivity as a function of photoinjection energy is studied by Monte Carlo simulation in quasi-one-dimensional quantum wire structures. It is demonstrated that the amplitude of the oscillations of photoconductivity may be so large that this leads to a negative absolute conductivity at injection energies that are multiples of the optical phonon energy. These oscillations are associated with inelastic optical phonon scattering, leading to an asymmetric electron distribution function established under conditions of intensive electron photoinjection to the subband bottom or close to energies that are multiples of the optical phonon energy. Simulation results suggest that quasi-one-dimensional quantum wires are ideal for the experimental observation of negative absolute conductivity at low lattice temperatures. To achieve negative conductivity at room temperature one needs extremely high recombination rates. The oscillations of photoconductivity can reveal the spectrum of optical phonons in quantum wires, which differs considerably from that in bulk materials. C1 USA,RES OFF,RES TRIANGLE PK,NC 27709. USA,ELECTR TECHNOL & DEVICES LAB,SLCET ED,FT MONMOUTH,NJ 07703. RP MICKEVICIUS, R (reprint author), WAYNE STATE UNIV,DEPT ELECT & COMP ENGN,DETROIT,MI 48202, USA. NR 26 TC 7 Z9 9 U1 0 U2 0 PU IOP PUBLISHING LTD PI BRISTOL PA TECHNO HOUSE, REDCLIFFE WAY, BRISTOL, ENGLAND BS1 6NX SN 0953-8984 J9 J PHYS-CONDENS MAT JI J. Phys.-Condes. Matter PD APR 5 PY 1993 VL 5 IS 14 BP 2233 EP 2254 DI 10.1088/0953-8984/5/14/019 PG 22 WC Physics, Condensed Matter SC Physics GA KW693 UT WOS:A1993KW69300019 ER PT J AU OH, SK CERDA, S LEE, BG BLANCHARD, GC WALKER, JE HARTSHORN, K AF OH, SK CERDA, S LEE, BG BLANCHARD, GC WALKER, JE HARTSHORN, K TI PARTIAL-PURIFICATION AND IDENTIFICATION OF AN IMMUNOSUPPRESSIVE FACTOR IN AIDS SERA SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Article ID IMMUNE-DEFICIENCY SYNDROME; ACQUIRED IMMUNODEFICIENCY SYNDROME; SUPPRESSOR FACTORS; ENVELOPE PROTEIN; VIRUS-INFECTION; EFFECTOR-CELLS; CYTO-TOXICITY; T-CELLS; INTERLEUKIN-2; HIV-1 AB The cause of the profound immunodeficiency state induced by the human immunodeficiency virus (HIV) is not yet fully understood. Although direct cytopathic effects of the virus leading to the loss of CD4+ lymphocytes are believed to play a major role, soluble factors that cause lymphocyte dysfunction have also been identified. Here, we demonstrate that sera of AIDS patients contain a viral component capable of profoundly inhibiting normal T lymphocyte and natural killer cell functions. This factor (M(r) 30,000-50,000) is relatively resistant to proteolytic degradation, heat denaturation, extreme pH, and chemical modifications. It has been determined by Western blotting to share epitopes with the gp41 viral transmembrane component of HIV-1. This immunosuppressive factor has the characteristic property of inhibiting lymphocyte activation in the early stage (within 3 hr) of mitogenic stimulation. Concomitant with the inhibition of lymphocyte activation and interleukin 2 (IL-2) production, transcription of the IL-2 message is also reduced in a time-dependent manner. The unique time dependency of this immunosuppressive factor in lymphocyte activation could serve as a valuable tool to study the early steps of signal transduction in lymphocyte activation beyond membrane interaction. C1 BOSTON UNIV,SCH MED,DEPT MICROBIOL,BOSTON,MA 02118. PACIFIC CHEM CO LTD,SEOUL,SOUTH KOREA. NATICK ARMY RES & DEV CTR,NATICK,MA 01760. VET ADM MED CTR JAMAICA PLAIN,BOSTON,MA 02130. BOSTON UNIV,SCH MED,DEPT HEMATOL,BOSTON,MA 02118. NR 47 TC 10 Z9 10 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD APR PY 1993 VL 9 IS 4 BP 365 EP 373 DI 10.1089/aid.1993.9.365 PG 9 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA KY808 UT WOS:A1993KY80800011 PM 7685613 ER PT J AU VUKELJA, SJ AF VUKELJA, SJ TI HEMOGLOBIN KORLE-BU (G-ACCRA) IN COMBINATION WITH HEMOGLOBIN-C SO AMERICAN JOURNAL OF HEMATOLOGY LA English DT Letter RP VUKELJA, SJ (reprint author), BROOKE ARMY MED CTR,DEPT MED,FT SAM HOUSTON,TX 78234, USA. NR 10 TC 1 Z9 1 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0361-8609 J9 AM J HEMATOL JI Am. J. Hematol. PD APR PY 1993 VL 42 IS 4 BP 412 EP 412 DI 10.1002/ajh.2830420427 PG 1 WC Hematology SC Hematology GA KU623 UT WOS:A1993KU62300027 PM 8494004 ER PT J AU BERG, BW DILLARD, TA DERDERIAN, SS RAJAGOPAL, KR AF BERG, BW DILLARD, TA DERDERIAN, SS RAJAGOPAL, KR TI HEMODYNAMIC-EFFECTS OF ALTITUDE EXPOSURE AND OXYGEN ADMINISTRATION IN CHRONIC OBSTRUCTIVE PULMONARY-DISEASE SO AMERICAN JOURNAL OF MEDICINE LA English DT Article ID AIR-TRAVEL; PULSUS PARADOXUS; ADAPTATION; MECHANISMS; HYPOXEMIA; HYPOXIA; CURVE AB PURPOSE: Cardiovascular events are the leading cause of death during air travel. Because patients with chronic obstructive pulmonary disease (COPD) develop severe hypoxemia at altitude, we sought to determine whether changes in systemic hemodynamics may contribute to health risks during hypobaric hypoxia. PATIENTS AND METHODS: We recorded radial artery catheter blood pressure, cardiac frequency, and cardiac ectopy in 18 men (aged 68 +/- 6 years, mean +/- SD) with severe COPD (forced expiratory volume in 1 second 0.97 L +/- 0.32 L) at sea level, after 45 minutes of steady-state hypobaric hypoxia at 2,438 m in a hypobaric chamber, and after oxygen supplementation at 2,438 m. RESULTS: Mean arterial pressure (mm Hg), systolic blood pressure (SBP), diastolic blood pressure, and pulsus paradoxus during acute hypobaric exposure did not differ from baseline. During oxygen supplementation, SBP declined (p = 0.028). Decreases in pulsus paradoxus and pulse pressure were noted on oxygen (p < 0.05). We found no changes in cardiac frequency. Cardiac ectopy was uncommon; for one subject, ectopy increased with hypobaric hypoxia and decreased with oxygen administration. CONCLUSION: Vasopressor responses to hypoxia do not add to the risk of air travel in patients with severe COPD. Supplemental oxygen may cause beneficial hemodynamic changes in patients with COPD during acute hypobaric exposure. C1 WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,DEPT MED,BETHESDA,MD 20814. RP BERG, BW (reprint author), WALTER REED ARMY MED CTR,DEPT MED,PULM & CRIT CARE MED SERV,WASHINGTON,DC 20307, USA. NR 29 TC 18 Z9 18 U1 0 U2 2 PU EXCERPTA MEDICA INC PI NEW YORK PA 245 WEST 17TH STREET, NEW YORK, NY 10011 SN 0002-9343 J9 AM J MED JI Am. J. Med. PD APR PY 1993 VL 94 IS 4 BP 407 EP 412 DI 10.1016/0002-9343(93)90152-F PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA KX941 UT WOS:A1993KX94100010 PM 8475934 ER PT J AU BRUNER, JP REED, GW SARNO, AP HARRINGTON, RA GOODMAN, MA AF BRUNER, JP REED, GW SARNO, AP HARRINGTON, RA GOODMAN, MA TI INTRAOBSERVER AND INTEROBSERVER VARIABILITY OF THE AMNIOTIC-FLUID INDEX SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Article DE INTRAOBSERVER VARIABILITY; INTEROBSERVER VARIABILITY; AMNIOTIC FLUID INDEX ID VOLUME AB OBJECTIVE: We assessed intraobserver and interobserver variations in the performance of the amniotic fluid index. STUDY DESIGN: A total of 34 women in the third trimester with intact membranes were examined twice by each of three examiners. The amniotic fluid index was measured once by each of the three examiners in order, then repeated by each examiner in the same order. Numeric displays on the video terminal screen were covered so that the examiners were blinded to actual measurement values. Results were recorded on hard copy for later data analysis. A senior investigator supervised all examinations to monitor consistency of technique. RESULTS: Overall, the coefficient of variation for amniotic fluid index measurements varied from 10.8% within examiners to 15.4% between examiners. Both between and within variation of absolute differences increased as the amniotic fluid index value increased, while the percent difference decreased. Simply repeating the test by the same examiner will decrease the coefficient of variation significantly. CONCLUSION: Although intraobserver and interobserver variability cannot be eliminated, its impact can be minimized by use of the same examiner for serial studies. C1 TRIPLER ARMY MED CTR,DEPT OBSTET & GYNECOL,HONOLULU,HI 96859. RP BRUNER, JP (reprint author), VANDERBILT UNIV,MED CTR,DEPT OBSTET & GYNECOL,B-1100 MCN,NASHVILLE,TN 37232, USA. NR 4 TC 20 Z9 21 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0002-9378 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD APR PY 1993 VL 168 IS 4 BP 1309 EP 1313 PG 5 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA KY813 UT WOS:A1993KY81300033 PM 8475980 ER PT J AU MCCARROLL, JE URSANO, RJ WRIGHT, KM FULLERTON, CS AF MCCARROLL, JE URSANO, RJ WRIGHT, KM FULLERTON, CS TI HANDLING BODIES AFTER VIOLENT DEATH - STRATEGIES FOR COPING SO AMERICAN JOURNAL OF ORTHOPSYCHIATRY LA English DT Article ID DISASTER; STRESS AB Interviews with and observations of experienced and inexperienced personnel were conducted to determine their coping strategies before, during, and after their work with the bodies of people who had died violently. Avoidance, denial, and social support from the work group and spouse appeared to facilitate coping. The implications of these findings for therapeutic intervention are discussed. C1 UNIFORMED SERV UNIV HLTH SCI,F EDWARD HERBERT SCH MED,DEPT PSYCHIAT,BETHESDA,MD 20814. RP MCCARROLL, JE (reprint author), WALTER REED ARMY INST RES,DEPT MIL PSYCHIAT,WASHINGTON,DC 20307, USA. NR 11 TC 34 Z9 34 U1 0 U2 0 PU AMER ORTHOPSYCHIATRIC ASSN PI NEW YORK PA 19 W 44TH ST, NEW YORK, NY 10036 SN 0002-9432 J9 AM J ORTHOPSYCHIAT JI Am. J. Orthopsychiatr. PD APR PY 1993 VL 63 IS 2 BP 209 EP 214 DI 10.1037/h0079438 PG 6 WC Psychiatry; Social Work SC Psychiatry; Social Work GA KY057 UT WOS:A1993KY05700006 PM 8484426 ER PT J AU MEBRAHTU, YB HENDRICKS, LD OSTER, CN LAWYER, PG PERKINS, PV PAMBA, H KOECH, D ROBERTS, CR AF MEBRAHTU, YB HENDRICKS, LD OSTER, CN LAWYER, PG PERKINS, PV PAMBA, H KOECH, D ROBERTS, CR TI LEISHMANIA-DONOVANI PARASITES IN THE NASAL SECRETIONS, TONSILLOPHARYNGEAL MUCOSA, AND URINE CENTRIFUGATES OF VISCERAL LEISHMANIASIS PATIENTS IN KENYA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID ZYMODEMES AB In the early 1930s, investigators of visceral leishmaniasis stated that Leishman-Donovan bodies are found in body fluids of kala-azar patients, for example, in urine, feces, semen, and nasal and pharyngeal secretions. Based on this finding, we investigated the diagnostic potential of nasal secretions, tonsillopharyngeal mucosal swabs, and urine centrifugates inoculated into Schneider's Drosophila Medium (containing antibiotics and antifungal agents) as well as with Giemsa-stained smears. Consequently, 64 randomly selected patients with visceral leishmaniasis from Kenya (59 who were splenic culture or Giemsa stain positive and five who were culture negative but Giemsa stain positive) were tested by three noninvasive methods. These tests were all performed before the patients were treated with Pentostam.(R) Cultures of nasal and tonsillopharyngeal swabs and urine centrifugates produced 28 positive samples representing 24 patients (37.5%). Moreover, a set of 25 Giemsa-stained slide smears made from the nasal and tonsillopharyngeal mucosa of 25 patients with visceral leishmaniasis who had not tested positive in cultures produced nine positives. Therefore, the overall total of patients who tested positive by all of the above methods was 33 or 51.6%. The cryopreserved Leishmania isolates were characterized by cellulose acetate electrophoresis using 20 enzyme systems. The isoenzyme profiles produced by the parasites were represented in five different L. donovani s.l. zymodemes. Representatives of these isolates were also characterized by DNA Southern blotting analysis, which corroborated the isoenzyme results. C1 KENYA GOVT MED RES CTR,NAIROBI,KENYA. WALTER REED ARMY INST RES,DEPT MED,WASHINGTON,DC 20307. WALTER REED ARMY INST RES,DEPT ENTOMOL,WASHINGTON,DC 20307. UNIV NAIROBI,FAC MED,NAIROBI,KENYA. RP MEBRAHTU, YB (reprint author), USA,MED RES UNIT,POB 30137,NAIROBI,KENYA. NR 17 TC 18 Z9 18 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD APR PY 1993 VL 48 IS 4 BP 530 EP 535 PG 6 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA LB692 UT WOS:A1993LB69200010 PM 8480861 ER PT J AU GORDON, SW LINTHICUM, KJ MOULTON, JR AF GORDON, SW LINTHICUM, KJ MOULTON, JR TI TRANSMISSION OF CRIMEAN-CONGO HEMORRHAGIC-FEVER VIRUS IN 2 SPECIES OF HYALOMMA TICKS FROM INFECTED ADULTS TO COFEEDING IMMATURE FORMS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID IXODID TICKS; REPLICATION; AFRICAN; ACARI; ANTIBODY; BIOLOGY; KOCH AB Crimean-Congo hemorrhagic fever (CCHF) virus was transmitted from infected adult Hyalomma ticks to uninfected larval and nymphal Hyalomma ticks while cofeeding on a guinea pig host that did not have a detectable viremia. When tested after feeding with infected adults, three (0.8%) of 370 H. truncatum larvae contained detectable CCHF virus (mean virus titer 10(1.6) plaque-forming units [PFU]/tick). The virus was transmitted transstadially from infected larvae and was detected in 15 (1.2%) of 1,253 nymphs and 12 (0.1%) of 2,049 adults. Virus was recovered from 18 (1.9%) of 931 H. impeltatum nymphs, which originated from larvae that cofed with infected adults. After H. impeltatum nymphs cofed with infected adults, CCHF virus was detected in 21 (4.3%) of 449 (mean virus titer 10(1.7) PFU/tick) fed nymphs, but none of 886 adults tested after molt. Results of this study indicate that a small proportion of either larvae or nymphs may acquire CCHF infection while cofeeding on a host without a detectable viremia. C1 USA,MED RES INST INFECT DIS,DIV DIS ASSESSMENT,DEPT EPIDEMIOL,FREDERICK,MD 21702. RI Gordon, Scott/B-8875-2011 NR 24 TC 43 Z9 48 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD APR PY 1993 VL 48 IS 4 BP 576 EP 580 PG 5 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA LB692 UT WOS:A1993LB69200016 PM 8480867 ER PT J AU DILLARD, TA HNATIUK, OW MCCUMBER, TR AF DILLARD, TA HNATIUK, OW MCCUMBER, TR TI MAXIMUM VOLUNTARY VENTILATION - SPIROMETRIC DETERMINANTS IN CHRONIC OBSTRUCTIVE PULMONARY-DISEASE PATIENTS AND NORMAL SUBJECTS SO AMERICAN REVIEW OF RESPIRATORY DISEASE LA English DT Article ID AIR-FLOW OBSTRUCTION; EXERCISE; STANDARDIZATION; PREDICTION; VOLUME AB The 12-s maximum voluntary ventilation (MVV) provides an estimate of the ventilatory reserves available to meet the physiologic demands of exercise. Earlier studies established a general relationship between MVV and FEV,. We hypothesized that the resting maximum inspiratory flow rate (MIFR) also serves as a clinically useful predictor of the MVV. A total of 105 subjects, 45 women and 60 men (age 57 +/- 5 yr, mean +/- SD), with expiratory impairment categories of severe (n = 26), moderate (n = 22), mild (n = 18), and normal (n = 39) based on FEV1 (percentage of predicted), comprised the study samples. The ratio MVV/FEV1 averaged 41 +/- 7 overall. The FEV1 correlated with MVV in normal subjects (p < 0.05, r2 = 0.642) and patients (p < 0.05, r2 = 0.787) better than MIFR (p < 0.05, r2 greater-than-or-equal-to 0.480). MIFR joined with FEV1 in multiple linear regression to significantly improve the description of MVV: MVV L/min = 30.77FEV1 (L) + 5.94MIFR (L/s) - 4.77 (n = 105; p < 0.05, r2 = 0.849). The 95% confidence limits for MVV varied from 90 to 110% of predicted from the equation for this sample. The factors sex and impairment category did not reduce the unexplained variability in MVV after inclusion of FEV1 and MIFR as covariates in ANOVA (p > 0.05). Addition of MIFR to the model with FEV1 produced greater improvement in r2 than Pi(max). We conclude that MIFR, although secondary in importance to FEV1, is a significant determinant of MVV in patients with COPD and normal subjects. Estimation of MVV from FEV1 alone is less accurate than either direct measurement of MVV or estimation by inclusion of MIFR. C1 WALTER REED ARMY MED CTR,DEPT MED,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. NR 28 TC 35 Z9 35 U1 1 U2 3 PU AMER LUNG ASSOC PI NEW YORK PA 1740 BROADWAY, NEW YORK, NY 10019 SN 0003-0805 J9 AM REV RESPIR DIS JI Am. Rev. Respir. Dis. PD APR PY 1993 VL 147 IS 4 BP 870 EP 875 PG 6 WC Respiratory System SC Respiratory System GA KV724 UT WOS:A1993KV72400014 PM 8466122 ER PT J AU ARGYROS, GJ TORRINGTON, KG AF ARGYROS, GJ TORRINGTON, KG TI PRESENTATION OF CARCINOMA METASTATIC TO THE THORAX AND DIAGNOSIS WITH FIBEROPTIC BRONCHOSCOPY SO AMERICAN REVIEW OF RESPIRATORY DISEASE LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,PULM & CRIT CARE MED SERV,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER LUNG ASSOC PI NEW YORK PA 1740 BROADWAY, NEW YORK, NY 10019 SN 0003-0805 J9 AM REV RESPIR DIS JI Am. Rev. Respir. Dis. PD APR PY 1993 VL 147 IS 4 SU S BP A524 EP A524 PG 1 WC Respiratory System SC Respiratory System GA LB149 UT WOS:A1993LB14901986 ER PT J AU ASSAAD, A WILHELMSEN, C PITT, L SWAUGER, J KOKES, J PARKER, G FRANZ, D AF ASSAAD, A WILHELMSEN, C PITT, L SWAUGER, J KOKES, J PARKER, G FRANZ, D TI RICIN, A PLANT TOXIN, INDUCES ACUTE LUNG INJURY AND HIGH PERMEABILITY PULMONARY-EDEMA IN RATS SO AMERICAN REVIEW OF RESPIRATORY DISEASE LA English DT Meeting Abstract C1 USA,MED RES INST INFECT DIS,FT DETRICK,MD 21702. NR 0 TC 3 Z9 3 U1 0 U2 1 PU AMER LUNG ASSOC PI NEW YORK PA 1740 BROADWAY, NEW YORK, NY 10019 SN 0003-0805 J9 AM REV RESPIR DIS JI Am. Rev. Respir. Dis. PD APR PY 1993 VL 147 IS 4 SU S BP A361 EP A361 PG 1 WC Respiratory System SC Respiratory System GA LB149 UT WOS:A1993LB14901358 ER PT J AU BAUER, RM YOUNG, GD KEELER, JR AF BAUER, RM YOUNG, GD KEELER, JR TI NEUROPEPTIDES MODULATE PHOSGENE-INDUCED LUNG INJURY IN GUINEA-PIGS SO AMERICAN REVIEW OF RESPIRATORY DISEASE LA English DT Meeting Abstract C1 USA,MED RES INST CHEM DEF,DIV PATHOPHYSIOL,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER LUNG ASSOC PI NEW YORK PA 1740 BROADWAY, NEW YORK, NY 10019 SN 0003-0805 J9 AM REV RESPIR DIS JI Am. Rev. Respir. Dis. PD APR PY 1993 VL 147 IS 4 SU S BP A365 EP A365 PG 1 WC Respiratory System SC Respiratory System GA LB149 UT WOS:A1993LB14901375 ER PT J AU BRASSARD, JM ANZUETO, A LEVINE, SM ANDRADE, F MAXWELL, LC LAWRENCE, RA JENKINSON, SG AF BRASSARD, JM ANZUETO, A LEVINE, SM ANDRADE, F MAXWELL, LC LAWRENCE, RA JENKINSON, SG TI EFFECTS OF HYPEROXIA ON RAT DIAPHRAGM FUNCTION SO AMERICAN REVIEW OF RESPIRATORY DISEASE LA English DT Meeting Abstract C1 UNIV TEXAS,HLTH SCI CTR,DEPT MED,SAN ANTONIO,TX 78284. UNIV TEXAS,HLTH SCI CTR,DEPT PHYSIOL,SAN ANTONIO,TX 78284. AUDIE L MURPHY MEM VET ADM MED CTR,SAN ANTONIO,TX 78284. BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234. NR 1 TC 0 Z9 0 U1 0 U2 0 PU AMER LUNG ASSOC PI NEW YORK PA 1740 BROADWAY, NEW YORK, NY 10019 SN 0003-0805 J9 AM REV RESPIR DIS JI Am. Rev. Respir. Dis. PD APR PY 1993 VL 147 IS 4 SU S BP A236 EP A236 PG 1 WC Respiratory System SC Respiratory System GA LB149 UT WOS:A1993LB14900878 ER PT J AU DERDERIAN, SS RAJAGOPAL, KR AF DERDERIAN, SS RAJAGOPAL, KR TI EFFECTS OF NALOXONE ON THE RESPONSE TO INSPIRATORY RESISTIVE LOADING IN PATIENTS WITH OBSTRUCTIVE SLEEP-APNEA SO AMERICAN REVIEW OF RESPIRATORY DISEASE LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,DEPT MED,BETHESDA,MD 20814. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER LUNG ASSOC PI NEW YORK PA 1740 BROADWAY, NEW YORK, NY 10019 SN 0003-0805 J9 AM REV RESPIR DIS JI Am. Rev. Respir. Dis. PD APR PY 1993 VL 147 IS 4 SU S BP A168 EP A168 PG 1 WC Respiratory System SC Respiratory System GA LB149 UT WOS:A1993LB14900614 ER PT J AU DILLARD, TA HNATIUK, OW AF DILLARD, TA HNATIUK, OW TI ESTIMATION OF MAXIMUM ACHIEVABLE VENTILATION USING FORCED EXPIRATORY FLOWS IN COPD PATIENTS SO AMERICAN REVIEW OF RESPIRATORY DISEASE LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,DEPT MED,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. NR 1 TC 0 Z9 0 U1 0 U2 0 PU AMER LUNG ASSOC PI NEW YORK PA 1740 BROADWAY, NEW YORK, NY 10019 SN 0003-0805 J9 AM REV RESPIR DIS JI Am. Rev. Respir. Dis. PD APR PY 1993 VL 147 IS 4 SU S BP A865 EP A865 PG 1 WC Respiratory System SC Respiratory System GA LB149 UT WOS:A1993LB14903310 ER PT J AU EASA, D MUNDIE, TG FINN, KC TAKENAKA, W BALARAMAN, V AF EASA, D MUNDIE, TG FINN, KC TAKENAKA, W BALARAMAN, V TI COMPARISON OF INCREMENTAL CONTINUOUS NEGATIVE EXTRATHORACIC PRESSURE VS POSITIVE END-EXPIRATORY PRESSURE IN SALINE-LAVAGED MECHANICALLY VENTILATED PIGLETS SO AMERICAN REVIEW OF RESPIRATORY DISEASE LA English DT Meeting Abstract C1 UNIV HAWAII,TRIPLER ARMY MED CTR,HONOLULU,HI 96822. UNIV HAWAII,KAPIOLANI MED CTR,HONOLULU,HI 96822. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER LUNG ASSOC PI NEW YORK PA 1740 BROADWAY, NEW YORK, NY 10019 SN 0003-0805 J9 AM REV RESPIR DIS JI Am. Rev. Respir. Dis. PD APR PY 1993 VL 147 IS 4 SU S BP A888 EP A888 PG 1 WC Respiratory System SC Respiratory System GA LB149 UT WOS:A1993LB14903399 ER PT J AU ELIASSON, AH POROPATICH, RK HOWARD, RS PHILLIPS, YY AF ELIASSON, AH POROPATICH, RK HOWARD, RS PHILLIPS, YY TI PFT PARAMETERS IN BRONCHOPROVOCATION TESTS SO AMERICAN REVIEW OF RESPIRATORY DISEASE LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER LUNG ASSOC PI NEW YORK PA 1740 BROADWAY, NEW YORK, NY 10019 SN 0003-0805 J9 AM REV RESPIR DIS JI Am. Rev. Respir. Dis. PD APR PY 1993 VL 147 IS 4 SU S BP A829 EP A829 PG 1 WC Respiratory System SC Respiratory System GA LB149 UT WOS:A1993LB14903168 ER PT J AU ELSAYED, NM SUMMEY, HF MUSTAFA, MG AF ELSAYED, NM SUMMEY, HF MUSTAFA, MG TI A COMPARISON BETWEEN THE BIOCHEMICAL RESPONSES OF RAT TRACHEA AND BRONCHI TO OZONE SO AMERICAN REVIEW OF RESPIRATORY DISEASE LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,WASHINGTON,DC 20307. UNIV CALIF LOS ANGELES,LOS ANGELES,CA 90024. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER LUNG ASSOC PI NEW YORK PA 1740 BROADWAY, NEW YORK, NY 10019 SN 0003-0805 J9 AM REV RESPIR DIS JI Am. Rev. Respir. Dis. PD APR PY 1993 VL 147 IS 4 SU S BP A925 EP A925 PG 1 WC Respiratory System SC Respiratory System GA LB149 UT WOS:A1993LB14903545 ER PT J AU FITZPATRICK, TM GUIMONT, JA MAYORGA, MA JANUSZKIEWICZ, AJ AF FITZPATRICK, TM GUIMONT, JA MAYORGA, MA JANUSZKIEWICZ, AJ TI EFFECTS OF NITROGEN-DIOXIDE EXPOSURE ON LEUKOTRIENE CONCENTRATION IN SHEEP BRONCHOALVEOLAR LAVAGE FLUID SO AMERICAN REVIEW OF RESPIRATORY DISEASE LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,DEPT RESP RES,DIV MED,WASHINGTON,DC 20307. NR 0 TC 2 Z9 2 U1 0 U2 0 PU AMER LUNG ASSOC PI NEW YORK PA 1740 BROADWAY, NEW YORK, NY 10019 SN 0003-0805 J9 AM REV RESPIR DIS JI Am. Rev. Respir. Dis. PD APR PY 1993 VL 147 IS 4 SU S BP A72 EP A72 PG 1 WC Respiratory System SC Respiratory System GA LB149 UT WOS:A1993LB14900240 ER PT J AU HAMM, CK DERDARIAN, SS BATES, FA RAYBURN, DB AF HAMM, CK DERDARIAN, SS BATES, FA RAYBURN, DB TI SLEEP STAGING FROM RESPIRATORY PATTERNS USING A BACK-PROPAGATION NEURAL-NETWORK SO AMERICAN REVIEW OF RESPIRATORY DISEASE LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER LUNG ASSOC PI NEW YORK PA 1740 BROADWAY, NEW YORK, NY 10019 SN 0003-0805 J9 AM REV RESPIR DIS JI Am. Rev. Respir. Dis. PD APR PY 1993 VL 147 IS 4 SU S BP A808 EP A808 PG 1 WC Respiratory System SC Respiratory System GA LB149 UT WOS:A1993LB14903083 ER PT J AU HURWITZ, KM ROACH, JM ARGYROS, GJ ELIASSON, AH PHILLIPS, YY AF HURWITZ, KM ROACH, JM ARGYROS, GJ ELIASSON, AH PHILLIPS, YY TI ANALYSIS OF REFRACTORY PERIOD AFTER SEQUENTIAL TESTING WITH EUCAPNIC VOLUNTARY HYPERVENTILATION AND METHACHOLINE INHALATION CHALLENGE SO AMERICAN REVIEW OF RESPIRATORY DISEASE LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER LUNG ASSOC PI NEW YORK PA 1740 BROADWAY, NEW YORK, NY 10019 SN 0003-0805 J9 AM REV RESPIR DIS JI Am. Rev. Respir. Dis. PD APR PY 1993 VL 147 IS 4 SU S BP A259 EP A259 PG 1 WC Respiratory System SC Respiratory System GA LB149 UT WOS:A1993LB14900958 ER PT J AU JOHNSON, JE HAYES, JA PEACOCK, MD ANDERS, GT BLANTON, HM AF JOHNSON, JE HAYES, JA PEACOCK, MD ANDERS, GT BLANTON, HM TI FORCED EXPIRATORY FLOW IS REDUCED BY 100-PERCENT OXYGEN IN PATIENTS WITH COPD SO AMERICAN REVIEW OF RESPIRATORY DISEASE LA English DT Meeting Abstract C1 BROOKE ARMY MED CTR,PULM DIS CRIT CARE SERV,FT SAM HOUSTON,TX 78234. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER LUNG ASSOC PI NEW YORK PA 1740 BROADWAY, NEW YORK, NY 10019 SN 0003-0805 J9 AM REV RESPIR DIS JI Am. Rev. Respir. Dis. PD APR PY 1993 VL 147 IS 4 SU S BP A863 EP A863 PG 1 WC Respiratory System SC Respiratory System GA LB149 UT WOS:A1993LB14903300 ER PT J AU MUNDIE, TG EASA, D FINN, K HASHIRO, G BALARAMAN, V AF MUNDIE, TG EASA, D FINN, K HASHIRO, G BALARAMAN, V TI COMPARISON OF CONTINUOUS NEGATIVE EXTRATHORACIC PRESSURE AND POSITIVE END-EXPIRATORY PRESSURE IN ENDOTOXIN-TREATED NEONATAL PIGLETS SO AMERICAN REVIEW OF RESPIRATORY DISEASE LA English DT Meeting Abstract C1 TRIPLER ARMY MED CTR,HONOLULU,HI 96859. UNIV HAWAII,KAPIOLANI MED CTR,HONOLULU,HI 96822. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER LUNG ASSOC PI NEW YORK PA 1740 BROADWAY, NEW YORK, NY 10019 SN 0003-0805 J9 AM REV RESPIR DIS JI Am. Rev. Respir. Dis. PD APR PY 1993 VL 147 IS 4 SU S BP A888 EP A888 PG 1 WC Respiratory System SC Respiratory System GA LB149 UT WOS:A1993LB14903398 ER PT J AU PARKER, JM DILLARD, TA PHILLIPS, YY AF PARKER, JM DILLARD, TA PHILLIPS, YY TI IMPACT OF USING STATED VERSUS MEASURED HEIGHT ON SCREENING SPIROMETRY SO AMERICAN REVIEW OF RESPIRATORY DISEASE LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER LUNG ASSOC PI NEW YORK PA 1740 BROADWAY, NEW YORK, NY 10019 SN 0003-0805 J9 AM REV RESPIR DIS JI Am. Rev. Respir. Dis. PD APR PY 1993 VL 147 IS 4 SU S BP A450 EP A450 PG 1 WC Respiratory System SC Respiratory System GA LB149 UT WOS:A1993LB14901706 ER PT J AU PEACOCK, MD JOHNSON, JE BLANTON, HM AF PEACOCK, MD JOHNSON, JE BLANTON, HM TI COMPLICATIONS OF FIBEROPTIC BRONCHOSCOPY IN PATIENTS WITH SEVERE CHRONIC OBSTRUCTIVE PULMONARY-DISEASE (COPD) SO AMERICAN REVIEW OF RESPIRATORY DISEASE LA English DT Meeting Abstract C1 BROOKE ARMY MED CTR,PULM DIS CRIT CARE SERV,FT SAM HOUSTON,TX 78234. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER LUNG ASSOC PI NEW YORK PA 1740 BROADWAY, NEW YORK, NY 10019 SN 0003-0805 J9 AM REV RESPIR DIS JI Am. Rev. Respir. Dis. PD APR PY 1993 VL 147 IS 4 SU S BP A866 EP A866 PG 1 WC Respiratory System SC Respiratory System GA LB149 UT WOS:A1993LB14903313 ER PT J AU RAYBURN, DB LEFFERTS, PL PLITMAN, JD SNAPPER, JR AF RAYBURN, DB LEFFERTS, PL PLITMAN, JD SNAPPER, JR TI USE OF BACK-PROPAGATION NEURAL-NETWORK TO IDENTIFY MEDIATOR-SPECIFIC CARDIOVASCULAR WAVE-FORMS SO AMERICAN REVIEW OF RESPIRATORY DISEASE LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,WASHINGTON,DC 20307. VANDERBILT UNIV,MED CTR,SCH MED,CTR LUNG RES,NASHVILLE,TN 37232. NR 1 TC 0 Z9 0 U1 0 U2 0 PU AMER LUNG ASSOC PI NEW YORK PA 1740 BROADWAY, NEW YORK, NY 10019 SN 0003-0805 J9 AM REV RESPIR DIS JI Am. Rev. Respir. Dis. PD APR PY 1993 VL 147 IS 4 SU S BP A624 EP A624 PG 1 WC Respiratory System SC Respiratory System GA LB149 UT WOS:A1993LB14902383 ER PT J AU ROACH, JM ARGYROS, GJ HURWITZ, KM ELIASSON, AH PHILLIPS, YY AF ROACH, JM ARGYROS, GJ HURWITZ, KM ELIASSON, AH PHILLIPS, YY TI EUCAPNIC VOLUNTARY HYPERVENTILATION WITH DRY GAS AS A BRONCHOPROVOCATION TECHNIQUE IN ASTHMATICS - COMPARISON WITH METHACHOLINE INHALATION SO AMERICAN REVIEW OF RESPIRATORY DISEASE LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,ULM & CRIT CARE MED SERV,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER LUNG ASSOC PI NEW YORK PA 1740 BROADWAY, NEW YORK, NY 10019 SN 0003-0805 J9 AM REV RESPIR DIS JI Am. Rev. Respir. Dis. PD APR PY 1993 VL 147 IS 4 SU S BP A258 EP A258 PG 1 WC Respiratory System SC Respiratory System GA LB149 UT WOS:A1993LB14900957 ER PT J AU TORRINGTON, KG BILELLO, JF HOPKINS, TK HALL, E AF TORRINGTON, KG BILELLO, JF HOPKINS, TK HALL, E TI POSTOPERATIVE PULMONARY CHANGES FOLLOWING LAPAROSCOPIC CHOLECYSTECTOMY SO AMERICAN REVIEW OF RESPIRATORY DISEASE LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,RESP THERAPY SERV,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,SURG SERV,WASHINGTON,DC 20307. NR 0 TC 1 Z9 1 U1 0 U2 0 PU AMER LUNG ASSOC PI NEW YORK PA 1740 BROADWAY, NEW YORK, NY 10019 SN 0003-0805 J9 AM REV RESPIR DIS JI Am. Rev. Respir. Dis. PD APR PY 1993 VL 147 IS 4 SU S BP A962 EP A962 PG 1 WC Respiratory System SC Respiratory System GA LB149 UT WOS:A1993LB14903694 ER PT J AU KUKHTAREV, N DOVGALENKO, G SHULTZ, J SALAMO, G SHARP, EJ WECHSLER, BA KLEIN, MB AF KUKHTAREV, N DOVGALENKO, G SHULTZ, J SALAMO, G SHARP, EJ WECHSLER, BA KLEIN, MB TI MANIFESTATION OF CIRCULAR PHOTOGALVANIC CURRENT BY DYNAMIC HOLOGRAPHY IN BATIO3 SO APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING LA English DT Article AB We report the first measurement of the photogalvanic circular current antisymmetric tensor component in BaTiO3: Co. The measurement gives a value of this coefficient, for extraordinary beam amplification, of 4 x 10(-9) A/W using a nonstationary measurement technique at a wavelength of 0.632 mum. C1 HUGHES RES LABS,MALIBU,CA 90265. USA,RES LAB,FT BELVOIR,VA 22060. RP KUKHTAREV, N (reprint author), UNIV ARKANSAS,DEPT PHYS,FAYETTEVILLE,AR 72701, USA. NR 8 TC 12 Z9 12 U1 0 U2 0 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0947-8396 J9 APPL PHYS A-MATER JI Appl. Phys. A-Mater. Sci. Process. PD APR PY 1993 VL 56 IS 4 BP 303 EP 305 DI 10.1007/BF00324346 PG 3 WC Materials Science, Multidisciplinary; Physics, Applied SC Materials Science; Physics GA KX795 UT WOS:A1993KX79500003 ER PT J AU ELSAYED, NM NAKASHIMA, JM POSTLETHWAIT, EM AF ELSAYED, NM NAKASHIMA, JM POSTLETHWAIT, EM TI MEASUREMENT OF URIC-ACID AS A MARKER OF OXYGEN-TENSION IN THE LUNG SO ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS LA English DT Article ID XANTHINE-OXIDASE; HYPOXANTHINE; ISCHEMIA; INOSINE; HYPEROXIA; HYPOXIA; HEART; ATP C1 UNIV CALIF LOS ANGELES,SCH PUBL HLTH,DEPT ENVIRONM HLTH SCI,LOS ANGELES,CA 90024. LETTERMAN ARMY INST RES,SAN FRANCISCO,CA 94129. UNIV TEXAS,MED BRANCH,DEPT INTERNAL MED,PULM RES LABS,GALVESTON,TX 77550. RP ELSAYED, NM (reprint author), WALTER REED ARMY INST RES,DEPT RESP RES,DIV MED,WASHINGTON,DC 20307, USA. NR 34 TC 30 Z9 31 U1 0 U2 0 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0003-9861 J9 ARCH BIOCHEM BIOPHYS JI Arch. Biochem. Biophys. PD APR PY 1993 VL 302 IS 1 BP 228 EP 232 DI 10.1006/abbi.1993.1204 PG 5 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA KW472 UT WOS:A1993KW47200033 PM 8470901 ER PT J AU BETTIS, VM VAUGHN, RY GUILL, MA AF BETTIS, VM VAUGHN, RY GUILL, MA TI ERYTHEMATOUS PLAQUES ON THE EYELIDS - DISCOID LUPUS-ERYTHEMATOSUS (DLE) SO ARCHIVES OF DERMATOLOGY LA English DT Note C1 EISENHOWER ARMY MED CTR,FT GORDON,GA. RP BETTIS, VM (reprint author), MED COLL GEORGIA,AUGUSTA,GA 30912, USA. NR 7 TC 0 Z9 0 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0003-987X J9 ARCH DERMATOL JI Arch. Dermatol. PD APR PY 1993 VL 129 IS 4 BP 495 EP & PG 0 WC Dermatology SC Dermatology GA KW765 UT WOS:A1993KW76500015 PM 8466225 ER PT J AU HARTUNG, GH LAWRENCE, SJ REEVES, RS FOREYT, JP AF HARTUNG, GH LAWRENCE, SJ REEVES, RS FOREYT, JP TI EFFECT OF ALCOHOL AND EXERCISE ON POSTPRANDIAL LIPEMIA AND TRIGLYCERIDE CLEARANCE IN MEN SO ATHEROSCLEROSIS LA English DT Article DE ALCOHOL; EXERCISE; LIPEMIA; TRIGLYCERIDE; CHOLESTEROL; LIPOPROTEIN ID DENSITY LIPOPROTEIN CHOLESTEROL; CORONARY HEART-DISEASE; INTRAVENOUS FAT TOLERANCE; SERUM-LIPOPROTEINS; LIPID-METABOLISM; PLASMA-LIPOPROTEINS; HDL-SUBFRACTIONS; APOLIPOPROTEINS; CONSUMPTION; FRAMINGHAM AB Alcohol intake and exercise have both been found to be related to increased plasma levels of high density lipoprotein cholesterol (HDLC). Exercise training results in decreased postprandial lipemia, and clearance rate of infused lipids is related to plasma lipoprotein levels in physically active men. The effect of alcohol intake on plasma triglyceride (TG) clearance has not been studied in relation to the exercise status of subjects. Plasma TG change over 8 h was determined following a liquid fatty meal in 14 male habitual runners (R) and 13 physically inactive men (I) after 3 weeks of alcohol abstinence and 3 weeks of drinking approximately 41 g (1.44 oz) of ethanol per day. Fasting total cholesterol and apolipoprotein A-1 (apo A-1) were not different between groups, but TG was lower and HDLC, HDL2C, and HDL3C were higher in the runners. After abstinence, I had slower TG clearance (P = 0.07) compared with R; with alcohol, TG clearance was unchanged in R, but was significantly retarded in I. With alcohol, both groups had increased HDLC levels, but this mainly was due to an increase in HDL3C in R and HDL2C in I; apo A-1 increased similarly in both groups and fasting TG increased significantly only in I. Alcohol-induced increases in postprandial lipemia and retardation of TG clearance appear to occur in inactive, but not exercise-trained subjects and the effect of alcohol on plasma HDL subfractions may differ between these groups. C1 BAYLOR COLL MED,DEPT MED,HOUSTON,TX 77030. RP HARTUNG, GH (reprint author), TRIPLER ARMY MED CTR,DEPT MED,CARDIOL SERV,HSHK DMC,HONOLULU,HI 96859, USA. FU NCRR NIH HHS [5-M01-RR00350] NR 29 TC 35 Z9 36 U1 0 U2 2 PU ELSEVIER SCI IRELAND LTD PI CLARE PA CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE, IRELAND SN 0021-9150 J9 ATHEROSCLEROSIS JI Atherosclerosis PD APR PY 1993 VL 100 IS 1 BP 33 EP 40 PG 8 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA LD840 UT WOS:A1993LD84000004 PM 8318061 ER PT J AU NOTTESTAD, SY SLIFE, DM RUBAL, BJ MOODY, JM AF NOTTESTAD, SY SLIFE, DM RUBAL, BJ MOODY, JM TI TETRALOGY OF FALLOT IN A 71-YEAR-OLD PATIENT WITH NEW ONSET HYPOXEMIA SO CATHETERIZATION AND CARDIOVASCULAR DIAGNOSIS LA English DT Article DE TETRALOGY OF FALLOT; HEMODYNAMICS; GERIATRIC; MODIFIED BLALOCK-TAUSSIG ID TERM FOLLOW-UP; REPAIR AB This study reports the evaluation and successful surgical management of a 71 year-old female with known Tetralogy of Fallot and symptomatic hypoxemia. A hybrid (fluid-micromanometer) catheter system was employed to examine right heart pressure gradients. This case presents unique hemodynamics along with angiography and palliative surgical management. RP NOTTESTAD, SY (reprint author), BROOKE ARMY MED CTR,DEPT MED,CARDIOL SERV,MDC,HSHE,FT SAM HOUSTON,TX 78234, USA. NR 6 TC 1 Z9 1 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0098-6569 J9 CATHETER CARDIO DIAG JI Catheter. Cardiovasc. Diagn. PD APR PY 1993 VL 28 IS 4 BP 335 EP 338 DI 10.1002/ccd.1810280413 PG 4 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA KU794 UT WOS:A1993KU79400012 PM 7681726 ER PT J AU CLAYSON, ET KELLY, SA MEIER, HL AF CLAYSON, ET KELLY, SA MEIER, HL TI EFFECTS OF SPECIFIC INHIBITORS OF CELLULAR FUNCTIONS ON SULFUR MUSTARD-INDUCED CELL-DEATH SO CELL BIOLOGY AND TOXICOLOGY LA English DT Article DE CELL VIABILITY; IN-VITRO ASSAYS; LIPID PEROXIDATION; LYMPHOCYTES; MONO(ADP-RIBOSE) TRANSFERASE; POLY(ADP-RIBOSE)POLYMERASE; SULFUR MUSTARD ID DEPENDENT LIPID-PEROXIDATION; POTENT INHIBITORS; ADP-RIBOSYLATION; NAD+ LEVELS; INVITRO; NICOTINAMIDE; ALLOPURINOL AB This study was conducted to determine whether inhibitors of normal cellular functions can reduce cytotoxicity induced by sulfur mustard (HD). The compounds examined include inhibitors of poly(ADP-ribose) polymerase (PADPRP), inhibitors of mono(ADP-ribose) transferase (MADPRT), inhibitors of lipid peroxidation, and an inhibitor of protein synthesis. To determine the effects of these compounds on HD-induced cell death, human lymphocyte preparations were treated with known concentrations (0.1 muM to 1000 muM) of an inhibitor and exposed to an estimated 87% effect concentration (EC87) of HD (170 muM) for loss in cell viability. Cell viability was determined at 24-26 hr post-exposure to HD using a dye (propidium iodide) exclusion assay and a flow cytometer. All of the selected PADPRP inhibitors were found to be effective at reducing the cytotoxic effects of HD. These inhibitors were rank-ordered based on the concentration that gives 50% (EC50) reduction of HD-induced cell death. A significant correlation (r = 0.94) was observed between the compounds' ability to inhibit PADPRP and the compounds' ability to reduce HD-induced cell death, suggesting that PADPRP plays a role in HD-induced cell death. Inhibitors of MADPRT, lipid peroxidation, and protein synthesis were not effective at reducing HD-induced cell death. C1 USA,MED RES INST CHEM DEF,BASIC ASSESSMENT BRANCH,SGRD UV DB,ABERDEEN PROVING GROUND,MD 21010. NR 31 TC 16 Z9 16 U1 0 U2 1 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 0742-2091 J9 CELL BIOL TOXICOL JI Cell Biol. Toxicol. PD APR-JUN PY 1993 VL 9 IS 2 BP 165 EP 175 DI 10.1007/BF00757578 PG 11 WC Cell Biology; Toxicology SC Cell Biology; Toxicology GA LT300 UT WOS:A1993LT30000006 PM 8242432 ER PT J AU ROACH, JM STAJDUHAR, KC TORRINGTON, KG AF ROACH, JM STAJDUHAR, KC TORRINGTON, KG TI RIGHT UPPER LOBE PULMONARY-EDEMA CAUSED BY ACUTE MITRAL REGURGITATION - DIAGNOSIS BY TRANSESOPHAGEAL ECHOCARDIOGRAPHY SO CHEST LA English DT Note ID LEFT HEART-FAILURE; PNEUMOTHORAX; COMPLICATION AB Unilateral pulmonary edema is a distinctly unusual clinical entity, often misdiagnosed initially as one of the more common causes of focal lung disease. Predominantly lobar pulmonary edema is rarer still. We report a case of right upper lobe pulmonary edema caused by the acute onset of severe mitral regurgitation. In addition, we briefly review the other causes of unilateral pulmonary edema, focusing on the cases that have been reported in association with heart failure and valvular heart disease. The majority of cases of right upper lobe pulmonary edema have been associated with mitral regurgitation. In addition to confirming the presence of mitral regurgitation, transesophageal echocardiography proved useful in delineating the mechanism for edema formation. It detected differential gradients between the right and left pulmonary venous systems and documented the direction of the regurgitant flow. C1 UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. RP ROACH, JM (reprint author), WALTER REED ARMY MED CTR,DEPT MED,PULM & CRIT CARE MED SERV,WASHINGTON,DC 20307, USA. NR 35 TC 39 Z9 39 U1 0 U2 0 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 SN 0012-3692 J9 CHEST JI Chest PD APR PY 1993 VL 103 IS 4 BP 1286 EP 1288 DI 10.1378/chest.103.4.1286 PG 3 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA KV850 UT WOS:A1993KV85000068 PM 8131490 ER PT J AU HARRINGTON, GR FROELICH, EG AF HARRINGTON, GR FROELICH, EG TI ADENOSINE-INDUCED TORSADES-DE-POINTES SO CHEST LA English DT Note ID SUPRAVENTRICULAR TACHYCARDIA; VERAPAMIL; DIAGNOSIS AB Physicians are finding increased applications for adenosine as a diagnostic and therapeutic modality for a variety of cardiac dysrhythmias. Its short half life and lack of reported major complications make it an ideal pharmacologic agent to utilize for diagnosis and treatment. Herein we report a case of polymorphic ventricular tachycardia induced by adenosine. RP HARRINGTON, GR (reprint author), WALTER REED ARMY MED CTR,CRIT CARE MED SERV,WASHINGTON,DC 20307, USA. NR 9 TC 21 Z9 21 U1 0 U2 0 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 SN 0012-3692 J9 CHEST JI Chest PD APR PY 1993 VL 103 IS 4 BP 1299 EP 1301 DI 10.1378/chest.103.4.1299 PG 3 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA KV850 UT WOS:A1993KV85000075 PM 8131497 ER PT J AU MOODY, JM BAILEY, SR RUBAL, BJ AF MOODY, JM BAILEY, SR RUBAL, BJ TI SUBTLE FEATURES OF THE HEMODYNAMIC-RESPONSE TO AMYL NITRITE INHALATION - NEW ASPECTS OF AN OLD TOOL SO CLINICAL CARDIOLOGY LA English DT Article DE AMYL NITRITE; VASODILATOR; BAROREFLEX; BLOOD PRESSURE; ARTERIAL REFLECTIONS ID PRESSURE; BAROREFLEX; IMPEDANCE; HEART AB Although amyl nitrite inhalation (ANI) antedates all current short acting vasodilators a clinically useful Pharmacologic stressor, few clinicians are aware of the subtle hemodynamic actions of this agent. This study examined transients in left and right heart hemodynamics after ANI in seven men (ages 44 +/- 7 years) undergoing elective cardiac catheterization. High-fidelity central aortic (AoP), left ventricular (LVP), pulmonary artery (PAP), right ventricular (RVP), and right atrial (RAP) pressures were simultaneously recorded from left and right heart multisensor catheters. As expected, ANI caused an acute fall in Ao pressure (27%; p < 0.01) and reflex tachycardia (p < 0.001). Little change was noted in PAP, RVP, RAP, or LV end-diastolic pressures or the time constant Of LV isovolumetric relaxation (tau). LV ejection time decreased 23 +/- 10 ms (p < 0.05) and RV ejection time did not change. Baroreflex sensitivity was similar during pressure fall and recovery (6.4 +/-4.5 vs. 6.1 +/- 3.6 ms/mmHg), however hysteresis (p < 0.05) was noted. Aortic pressure waveforms also changed following ANI. Changes were determined to be in part a consequence of the attenuation and delay in arterial wave reflections. This study extends the understanding of the complex nature of the hemodynamic response associated with ANI. C1 UNIV TEXAS,HLTH SCI CTR,DEPT MED,DIV CARDIOL,SAN ANTONIO,TX 78284. RP MOODY, JM (reprint author), BROOKE ARMY MED CTR,DEPT MED,CARDIOL SERV,HSHE,MDC,FT SAM HOUSTON,TX 78234, USA. NR 33 TC 4 Z9 4 U1 0 U2 0 PU CLINICAL CARDIOLOGY PUBL CO PI MAHWAH PA PO BOX 832, MAHWAH, NJ 07430-0832 SN 0160-9289 J9 CLIN CARDIOL JI Clin. Cardiol. PD APR PY 1993 VL 16 IS 4 BP 331 EP 338 PG 8 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA KU795 UT WOS:A1993KU79500008 PM 8096167 ER PT J AU JONES, R KLETTE, K KUHLMAN, JJ LEVINE, B SMITH, ML WATSON, CV SELAVKA, CM AF JONES, R KLETTE, K KUHLMAN, JJ LEVINE, B SMITH, ML WATSON, CV SELAVKA, CM TI TRIMETHOBENZAMIDE CROSS-REACTS IN IMMUNOASSAYS OF AMPHETAMINE METHAMPHETAMINE SO CLINICAL CHEMISTRY LA English DT Letter C1 USA,FORENS TOXICOL DRUG TESTING LAB,TRIPLER ARMY MED CTR,HI 96859. RP JONES, R (reprint author), ARMED FORCES INST PATHOL,DIV FORENS TOXICOL,WASHINGTON,DC 20306, USA. NR 2 TC 5 Z9 5 U1 0 U2 0 PU AMER ASSOC CLINICAL CHEMISTRY PI WASHINGTON PA 2101 L STREET NW, SUITE 202, WASHINGTON, DC 20037-1526 SN 0009-9147 J9 CLIN CHEM JI Clin. Chem. PD APR PY 1993 VL 39 IS 4 BP 699 EP 700 PG 2 WC Medical Laboratory Technology SC Medical Laboratory Technology GA KY291 UT WOS:A1993KY29100033 PM 8472376 ER PT J AU CIESLAK, TJ RASZKA, WV AF CIESLAK, TJ RASZKA, WV TI CATHETER-ASSOCIATED SEPSIS DUE TO ALCALIGENES-XYLOSOXIDANS IN A CHILD WITH AIDS SO CLINICAL INFECTIOUS DISEASES LA English DT Letter ID ACHROMOBACTER-XYLOSOXIDANS C1 WALTER REED ARMY MED CTR,DEPT PEDIAT,WASHINGTON,DC 20307. RP CIESLAK, TJ (reprint author), BROOKE ARMY MED CTR,DEPT PEDIAT,FT SAM HOUSTON,TX 78234, USA. NR 8 TC 19 Z9 19 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD APR PY 1993 VL 16 IS 4 BP 592 EP 593 PG 2 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA KU977 UT WOS:A1993KU97700032 PM 8357382 ER PT J AU LECKIE, RG DARROW, M DELAPLAIN, CB AF LECKIE, RG DARROW, M DELAPLAIN, CB TI SALMONELLA OSTEOMYELITIS IN AN HLA-B27 PATIENT SO CLINICAL NUCLEAR MEDICINE LA English DT Note C1 TRIPLER ARMY MED CTR,NUCL MED SERV,HONOLULU,HI 96859. JOHN A BURNS SCH MED,HONOLULU,HI. RP LECKIE, RG (reprint author), TRIPLER ARMY MED CTR,DEPT RADIOL,HONOLULU,HI 96859, USA. NR 4 TC 2 Z9 2 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0363-9762 J9 CLIN NUCL MED JI Clin. Nucl. Med. PD APR PY 1993 VL 18 IS 4 BP 346 EP 347 DI 10.1097/00003072-199304000-00018 PG 2 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA KX082 UT WOS:A1993KX08200018 PM 8482035 ER PT J AU LECKIE, RG WATABE, JT SHANLEY, DJ WERNER, M AF LECKIE, RG WATABE, JT SHANLEY, DJ WERNER, M TI TC-99M HDP BONE-SCINTIGRAPHY OF AMELOBLASTOMA WITH PANOREX, CT, MRI, AND GROSS CORRELATION SO CLINICAL NUCLEAR MEDICINE LA English DT Note C1 TRIPLER ARMY MED CTR,DEPT RADIOL,NUCL MED SERV,TRIPLER AMC,HI 96859. NR 4 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0363-9762 J9 CLIN NUCL MED JI Clin. Nucl. Med. PD APR PY 1993 VL 18 IS 4 BP 350 EP 352 DI 10.1097/00003072-199304000-00020 PG 3 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA KX082 UT WOS:A1993KX08200020 PM 8482037 ER PT J AU DRABICK, JJ NARAYANAN, RB WILLIAMS, JC LEDUC, JW NACY, CA AF DRABICK, JJ NARAYANAN, RB WILLIAMS, JC LEDUC, JW NACY, CA TI PASSIVE PROTECTION OF MICE AGAINST FRANCISELLA-TULARENSIS LVS-STRAIN INFECTION BY SERA OF RECIPIENTS OF THE LIVE TULAREMIA VACCINE SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 SN 0009-9279 J9 CLIN RES JI Clin. Res. PD APR PY 1993 VL 41 IS 2 BP A249 EP A249 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA KW761 UT WOS:A1993KW76100747 ER PT J AU FRUENDT, J VINCENT, DS AF FRUENDT, J VINCENT, DS TI TEACHING QUALITY ASSESSMENT IN AN AMBULATORY SETTING USING PERSONAL PRACTICE POLICIES SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 TRIPLER ARMY MED CTR,DEPT MED,GEN MED SERV,HONOLULU,HI 96859. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 SN 0009-9279 J9 CLIN RES JI Clin. Res. PD APR PY 1993 VL 41 IS 2 BP A557 EP A557 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA KW761 UT WOS:A1993KW76102545 ER PT J AU HARTMAN, KR KLIPPLE, G WARD, FT ATOLAGBE, TA AF HARTMAN, KR KLIPPLE, G WARD, FT ATOLAGBE, TA TI AUTOANTIBODIES TO MYELOID PRECURSOR CELLS IN AUTOIMMUNE NEUTROPENIA SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 SN 0009-9279 J9 CLIN RES JI Clin. Res. PD APR PY 1993 VL 41 IS 2 BP A164 EP A164 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA KW761 UT WOS:A1993KW76100292 ER PT J AU HARTMAN, KR ATOLAGBE, TA AF HARTMAN, KR ATOLAGBE, TA TI ANTINEUTROPHIL ANTIBODIES OF THE IG-M CLASS IN AUTOIMMUNE NEUTROPENIA SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 SN 0009-9279 J9 CLIN RES JI Clin. Res. PD APR PY 1993 VL 41 IS 2 BP A164 EP A164 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA KW761 UT WOS:A1993KW76100291 ER PT J AU HILL, J COCKERELL, CJ AF HILL, J COCKERELL, CJ TI HISTOLOGIC AND CLINICAL FINDINGS IN CUTANEOUS MERKEL CELL-CARCINOMA SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 BROOKE ARMY MED CTR,SAN ANTONIO,TX. UNIV TEXAS,SW MED CTR,DALLAS,TX 75235. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 SN 0009-9279 J9 CLIN RES JI Clin. Res. PD APR PY 1993 VL 41 IS 2 BP A428 EP A428 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA KW761 UT WOS:A1993KW76101773 ER PT J AU KARK, JA HETZEL, DP LINDGREN, KM LARKIN, TM GARDNER, JW JARMULOWICZ, MA AF KARK, JA HETZEL, DP LINDGREN, KM LARKIN, TM GARDNER, JW JARMULOWICZ, MA TI LIFE-THREATENING ARRHYTHMIAS IN EXERTIONAL HEAT-STROKE SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,DIV MED,WASHINGTON,DC 20307. WASHINGTON ADVENT HOSP,DEPT CARDIOL,WASHINGTON,DC. NAVAL HOSP,MED SERV,BEAUFORT,SC. UNIFORMED SERV UNIV HLTH SCI,WASHINGTON,DC. NAVAL HOSP,NURSING SERV,BEAUFORT,SC. NR 0 TC 1 Z9 1 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 SN 0009-9279 J9 CLIN RES JI Clin. Res. PD APR PY 1993 VL 41 IS 2 BP A341 EP A341 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA KW761 UT WOS:A1993KW76101268 ER PT J AU KIM, JH VAHEY, MT MCLINDEN, RJ MOSCA, JD BURKE, DS REDFIELD, RR AF KIM, JH VAHEY, MT MCLINDEN, RJ MOSCA, JD BURKE, DS REDFIELD, RR TI MECHANISM AND TRANSCRIPTIONAL EFFECTS OF HIV-1 SUPERINFECTION OF CHRONICALLY INFECTED CELL-LINES SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,ROCKVILLE,MD. HENRY M JACKSON FDN,ROCKVILLE,MD. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 SN 0009-9279 J9 CLIN RES JI Clin. Res. PD APR PY 1993 VL 41 IS 2 BP A322 EP A322 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA KW761 UT WOS:A1993KW76101161 ER PT J AU KNAUS, WA HARRELL, F FISHER, CJ OPAL, S SADOFF, J WAGNER, DP AF KNAUS, WA HARRELL, F FISHER, CJ OPAL, S SADOFF, J WAGNER, DP TI EVALUATING NEW DRUGS FOR SEPSIS - A PROSPECTIVE-STUDY DESIGN BASED ON SURVIVAL ANALYSIS SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 GEORGE WASHINGTON UNIV,MED CTR,ICU RES UNIT,WASHINGTON,DC 20037. DUKE UNIV,MED CTR,DIV BIOMETRY,DURHAM,NC 27710. CLEVELAND CLIN EDUC FDN,CRIT CARE RES UNIT,CLEVELAND,OH 44106. BROWN UNIV,PROVIDENCE,RI 02912. WALTER REED ARMY INST RES,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 SN 0009-9279 J9 CLIN RES JI Clin. Res. PD APR PY 1993 VL 41 IS 2 BP A252 EP A252 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA KW761 UT WOS:A1993KW76100768 ER PT J AU KROENKE, K LUCAS, CA ROSENBERG, ML SCHEROKMAN, B HERBERS, JE AF KROENKE, K LUCAS, CA ROSENBERG, ML SCHEROKMAN, B HERBERS, JE TI THE ONE-YEAR OUTCOME IN PATIENTS WITH A CHIEF COMPLAINT OF DIZZINESS SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 UNIFORMED SERV UNIV HLTH SCI,DEPT MED,BETHESDA,MD 20814. UNIFORMED SERV UNIV HLTH SCI,DEPT NEUROL,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 SN 0009-9279 J9 CLIN RES JI Clin. Res. PD APR PY 1993 VL 41 IS 2 BP A520 EP A520 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA KW761 UT WOS:A1993KW76102324 ER PT J AU LANDRY, FJ KROENKE, K LUCAS, C REEDER, J AF LANDRY, FJ KROENKE, K LUCAS, C REEDER, J TI INCREASING THE USE OF ADVANCE DIRECTIVES IN OUTPATIENTS - A RANDOMIZED TRIAL OF A PATIENT SEMINAR VERSUS WRITTEN INFORMATION SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 MADIGAN ARMY MED CTR,DEPT MED,TACOMA,WA 98431. WALTER REED ARMY MED CTR,DEPT MED,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. NR 0 TC 0 Z9 0 U1 0 U2 1 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 SN 0009-9279 J9 CLIN RES JI Clin. Res. PD APR PY 1993 VL 41 IS 2 BP A542 EP A542 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA KW761 UT WOS:A1993KW76102456 ER PT J AU MARPLE, R LUCEY, C KORENKE, K WILDER, J LUCAS, C AF MARPLE, R LUCEY, C KORENKE, K WILDER, J LUCAS, C TI A PROSPECTIVE-STUDY OF THE CONCERNS AND EXPECTATIONS IN PATIENTS PRESENTING WITH COMMON SYMPTOMS SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,DEPT MED,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. NR 0 TC 2 Z9 2 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 SN 0009-9279 J9 CLIN RES JI Clin. Res. PD APR PY 1993 VL 41 IS 2 BP A579 EP A579 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA KW761 UT WOS:A1993KW76102676 ER PT J AU ROY, MJ SEIDMAN, A LUCAS, C KROENKE, K HERBERS, JE AF ROY, MJ SEIDMAN, A LUCAS, C KROENKE, K HERBERS, JE TI IMPROVING PATIENT SATISFACTION WITH THE TRANSFER OF CARE - A RANDOMIZED CONTROLLED TRIAL SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 SN 0009-9279 J9 CLIN RES JI Clin. Res. PD APR PY 1993 VL 41 IS 2 BP A563 EP A563 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA KW761 UT WOS:A1993KW76102578 ER PT J AU RUSSO, TA LIANG, Y CROSS, AS AF RUSSO, TA LIANG, Y CROSS, AS TI THE PRESENCE OF K54 CAPSULAR POLYSACCHARIDE INCREASES THE PATHOGENICITY OF ESCHERICHIA-COLI INVIVO SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 NIAID,CLIN INVEST LAB,BETHESDA,MD 20892. WALTER REED ARMY INST RES,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 SN 0009-9279 J9 CLIN RES JI Clin. Res. PD APR PY 1993 VL 41 IS 2 BP A248 EP A248 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA KW761 UT WOS:A1993KW76100740 ER PT J AU SCHNEIDER, H DEAL, CD KUSCHNER, RA CROSS, AS AF SCHNEIDER, H DEAL, CD KUSCHNER, RA CROSS, AS TI EXPERIMENTAL URETHRITIS IN VOLUNTEERS FOLLOWING INTRAURETHRAL CHALLENGE WITH SMALL NUMBERS OF NEISSERIA-GONORRHOEAE SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 SN 0009-9279 J9 CLIN RES JI Clin. Res. PD APR PY 1993 VL 41 IS 2 BP A381 EP A381 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA KW761 UT WOS:A1993KW76101506 ER PT J AU SMITH, KJ MCCARTHY, W SKELTON, H LEDSKY, R YEAGER, J WAGNER, K AF SMITH, KJ MCCARTHY, W SKELTON, H LEDSKY, R YEAGER, J WAGNER, K TI HYPEREOSINOPHILIA AND HIV-1 DISEASE - A PREDICTOR OF PROLONGED SURVIVAL IN LATE STATE DISEASE SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES, WASHINGTON, DC 20307 USA. ARMED FORCES INST PATHOL, WASHINGTON, DC 20306 USA. NATL NAVAL MED CTR, BETHESDA, MD 20814 USA. HENRY M JACKSON FDN, BETHESDA, MD USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 SN 0009-9279 J9 CLIN RES JI Clin. Res. PD APR PY 1993 VL 41 IS 2 BP A472 EP A472 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA KW761 UT WOS:A1993KW76102037 ER PT J AU WILLIAMS, WJ YUAN, L FINKELMAN, M SIBER, GR CROSS, AS AF WILLIAMS, WJ YUAN, L FINKELMAN, M SIBER, GR CROSS, AS TI EFFICACY OF ENDOTOXIN NEUTRALIZING PROTEIN IN A MOUSE MODEL OF SEPSIS SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,WASHINGTON,DC 20307. ASSOCIATES CAPE COD INC,FALMOUTH,MA. HARVARD UNIV,SCH MED,DANA FARBER CANC INST,BOSTON,MA 02115. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 SN 0009-9279 J9 CLIN RES JI Clin. Res. PD APR PY 1993 VL 41 IS 2 BP A173 EP A173 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA KW761 UT WOS:A1993KW76100345 ER PT J AU BLANK, S AF BLANK, S TI WE CAN LIVE WITHOUT YOU - RIVALRY AND DIALOG IN RUSSO-JAPANESE RELATIONS SO COMPARATIVE STRATEGY LA English DT Article AB This article is a comprehensive examination of recent Russian relations with Japan in all its aspects: economic, military, political, and the problem of the Kurile Islands. It also is cast in the wider context of Russian strategy in Asia and in the context of the relationship between Japan, Russia, and the United States that is fundamentally structured by the U.S.-Japan Mutual Defense Treaty. It examines the impasse in the bilateral relationship of Russia and Japan in those contexts and dimensions in order to explain not only why the Kurile Islands poses so intractable an issue but why the overall relationship is likely to continue to be unresolved for some time to come. A continuing strain in Russo-Japanese relations will not bring us back to the cold war in Asia, but it will perpetuate the enduring regional tensions that antedated it and were subsumed in it. Thus, this continuing bilateral tension will retard the stabilization of the Asia-Pacific region's security structure. RP BLANK, S (reprint author), USA,COLL WAR,INST STRATEG STUDIES,CARLISLE,PA, USA. NR 61 TC 0 Z9 0 U1 0 U2 0 PU TAYLOR & FRANCIS PI BRISTOL PA 1900 FROST ROAD, SUITE 101, BRISTOL, PA 19007-1598 SN 0149-5933 J9 COMP STRATEGY PD APR-JUN PY 1993 VL 12 IS 2 BP 173 EP 198 DI 10.1080/01495939308402917 PG 26 WC International Relations; Political Science SC International Relations; Government & Law GA LL248 UT WOS:A1993LL24800004 ER PT J AU BEHR, MA FRANCA, LP TEZDUYAR, TE AF BEHR, MA FRANCA, LP TEZDUYAR, TE TI STABILIZED FINITE-ELEMENT METHODS FOR THE VELOCITY PRESSURE STRESS FORMULATION OF INCOMPRESSIBLE FLOWS SO COMPUTER METHODS IN APPLIED MECHANICS AND ENGINEERING LA English DT Article ID VISCOELASTIC FLOWS AB Formulated in terms of velocity, pressure and the extra stress tensor, the incompressible Navier-Stokes equations are discretized by stabilized finite element methods. The stabilized methods proposed are analyzed for a linear model and extended to the Navier-Stokes equations. The numerical tests performed confirm the good stability characteristics of the methods. These methods are applicable to various combinations of interpolation functions, including the simplest equal-order linear and bilinear elements. C1 LAB NACL COMP CIENT,CNPQ,RUA LAURO MULLER 445,BR-2290 RIO JANEIRO,RJ,BRAZIL. MINNESOTA SUPERCOMP INST,MINNEAPOLIS,MN 55415. USA,HIGH PERFORMANCE COMP RES CTR,DEPT AEROSP ENGN & MECH,MINNEAPOLIS,MN 55415. RI Behr, Marek/H-5401-2011; Tezduyar, Tayfun/F-6134-2012 OI Behr, Marek/0000-0003-4257-8276; Tezduyar, Tayfun/0000-0001-8707-3162 NR 16 TC 69 Z9 70 U1 1 U2 9 PU ELSEVIER SCIENCE SA LAUSANNE PI LAUSANNE 1 PA PO BOX 564, 1001 LAUSANNE 1, SWITZERLAND SN 0045-7825 J9 COMPUT METHOD APPL M JI Comput. Meth. Appl. Mech. Eng. PD APR PY 1993 VL 104 IS 1 BP 31 EP 48 DI 10.1016/0045-7825(93)90205-C PG 18 WC Engineering, Multidisciplinary; Mathematics, Interdisciplinary Applications; Mechanics SC Engineering; Mathematics; Mechanics GA KW932 UT WOS:A1993KW93200003 ER PT J AU CHEN, ZX AF CHEN, ZX TI PROJECTION FINITE-ELEMENT METHODS FOR SEMICONDUCTOR-DEVICE EQUATIONS SO COMPUTERS & MATHEMATICS WITH APPLICATIONS LA English DT Article AB In this paper, a class of nonstandard finite element methods, which we call projection finite element methods, is introduced to numerically solve the stationary drift-diffusion semiconductor device equations in two and three space dimensions. The methods are based on the use of nonconforming finite elements and the projection of coefficients into finite element spaces, produce symmetric and positive definite systems of algebraic equations, allow to design optimal order multigrid methods for the solution of the linear systems, and yield error estimates of high order. Numerical results are presented to show the performance of the methods. RP CHEN, ZX (reprint author), UNIV MINNESOTA,ARMY HIGH PERFORMANCE COMP RES CTR,1100 WASHINGTON AVE S,MINNEAPOLIS,MN 55415, USA. NR 14 TC 14 Z9 14 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0898-1221 J9 COMPUT MATH APPL JI Comput. Math. Appl. PD APR PY 1993 VL 25 IS 8 BP 81 EP 88 DI 10.1016/0898-1221(93)90173-S PG 8 WC Mathematics, Applied SC Mathematics GA KQ801 UT WOS:A1993KQ80100006 ER PT J AU MCMULLEN, RK NORTON, AR AF MCMULLEN, RK NORTON, AR TI SOMALIA AND OTHER ADVENTURES FOR THE 1990S SO CURRENT HISTORY LA English DT Article RP MCMULLEN, RK (reprint author), US MIL ACAD,DEPT SOCIAL SCI,W POINT,NY 10996, USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU CURRENT HIST INC PI PHILADELPHIA PA 4225 MAIN ST PO BOX 4647, PHILADELPHIA, PA 19127 SN 0011-3530 J9 CURR HIST JI Curr. Hist. PD APR PY 1993 VL 92 IS 573 BP 169 EP 174 PG 6 WC International Relations; Political Science SC International Relations; Government & Law GA KV167 UT WOS:A1993KV16700005 ER PT J AU BURKE, DS AF BURKE, DS TI HIV-INFECTION AND AIDS SO CURRENT OPINION IN INFECTIOUS DISEASES LA English DT Editorial Material RP BURKE, DS (reprint author), WALTER REED ARMY INST RES,DIV RETROVIROL,13 TAFT COURT,ROCKVILLE,MD 20850, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU RAPID SCIENCE PUBLISHERS PI LONDON PA 2-6 BOUNDARY ROW, LONDON, ENGLAND SE1 8NH SN 0951-7375 J9 CURR OPIN INFECT DIS JI Curr. Opin. Infect. Dis. PD APR PY 1993 VL 6 IS 2 BP 179 EP 180 DI 10.1097/00001432-199304000-00008 PG 2 WC Infectious Diseases SC Infectious Diseases GA KW705 UT WOS:A1993KW70500008 ER PT J AU MAYERS, DL AF MAYERS, DL TI ZIDOVUDINE AND OTHER ANTIRETROVIRAL AGENTS INCLUDING DRUG-INTERACTIONS AND TOXICITIES SO CURRENT OPINION IN INFECTIOUS DISEASES LA English DT Article AB Recent clinical trials are clarifying the use of antiretroviral agents in human immunodeficiency virus-positive patients. Zidovudine has shown antiretroviral activity at daily doses of 300 to 1200 mg. Didanosine can delay the onset of acquired immunodeficiency syndrome after prolonged treatment with zidovudine. Zidovudine plus dideoxycytidine therapy was observed to double the CD4 rise and duration of CD4 response in patients with advanced human immunodeficiency virus disease relative to historic controls. The limitations of dideoxynucleoside agents have become apparent as the virus continues to replicate in the presence of these drugs. Patients ultimately decline clinically and the drug-resistant virus emerges. Drug-resistant human immunodeficiency virus isolates in children have been associated with clinical decline. The association of drug resistance with immune dysfunction in the host, certain virus phenotypes, and increased viral burden has limited efforts to determine the clinical and public health implications of drug resistance. Additional toxicities and drug interactions have been observed with expanded use of antiretroviral drugs including cardiomyopathy with zidovudine and didanosine use, leukocytoclastic vasculitis with zidovudine use, and retinal lesions in children on didanosine. Trials are in progress to define the role of single agents and combination antiretroviral therapy. There is an urgent need to develop new classes of antiretroviral agents to treat human immunodeficiency virus-infected patients. C1 WALTER REED ARMY INST RES,ROCKVILLE,MD. NR 0 TC 6 Z9 6 U1 0 U2 0 PU RAPID SCIENCE PUBLISHERS PI LONDON PA 2-6 BOUNDARY ROW, LONDON, ENGLAND SE1 8NH SN 0951-7375 J9 CURR OPIN INFECT DIS JI Curr. Opin. Infect. Dis. PD APR PY 1993 VL 6 IS 2 BP 210 EP 217 DI 10.1097/00001432-199304000-00013 PG 8 WC Infectious Diseases SC Infectious Diseases GA KW705 UT WOS:A1993KW70500013 ER PT J AU NORTON, SA AF NORTON, SA TI FIJIAN PENIS MARBLES - AN EXAMPLE OF ARTIFICIAL PENILE NODULES SO CUTIS LA English DT Article AB Artificial penile nodules are inert objects inserted beneath the skin of the penis to enhance the pleasure of female sexual partners during intercourse. The practice is most common among men from southeast Asia. This report describes a Fijian man who had an artificial penile nodule made from a whittled-down plastic toothbrush handle. Although some authors believe that the use of artificial penile nodules arose after World War II, the practice was discussed in the Kama Sutra, the classic Indian treatise on love. C1 TRIPLER ARMY MED CTR,DERMATOL SERV,HONOLULU,HI 96859. NR 18 TC 8 Z9 8 U1 0 U2 1 PU EXCERPTA MEDICA INC PI NEW YORK PA 245 WEST 17TH STREET, NEW YORK, NY 10011 SN 0011-4162 J9 CUTIS JI Cutis PD APR PY 1993 VL 51 IS 4 BP 295 EP 297 PG 3 WC Dermatology SC Dermatology GA PK092 UT WOS:A1993PK09200017 PM 8477613 ER PT J AU KRINITZSKY, EL AF KRINITZSKY, EL TI EARTHQUAKE PROBABILITY IN ENGINEERING .1. THE USE AND MISUSE OF EXPERT OPINION SO ENGINEERING GEOLOGY LA English DT Article AB The Lawrence Livermore National Laboratory and the Electric Power Research Institute have developed procedures that statistically merge multiple expert opinions to get probabilistic seismic hazard evaluations. Such methods are intrinsically defective and should not be used for design applications in engineering. RP KRINITZSKY, EL (reprint author), US CORPS ENGINEERS,WATERWAYS EXPT STN,GEOTECH LAB,VICKSBURG,MS 39180, USA. NR 0 TC 37 Z9 37 U1 0 U2 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0013-7952 J9 ENG GEOL JI Eng. Geol. PD APR PY 1993 VL 33 IS 4 BP 257 EP 288 DI 10.1016/0013-7952(93)90030-G PG 32 WC Engineering, Geological; Geosciences, Multidisciplinary SC Engineering; Geology GA KX899 UT WOS:A1993KX89900002 ER PT J AU SADUSKY, MC SKELLY, JM SIMINI, M CHECKAI, RT WENTSEL, RS AF SADUSKY, MC SKELLY, JM SIMINI, M CHECKAI, RT WENTSEL, RS TI HEXACHLOROETHANE OBSCURANT - ASSESSING TREE FOLIAGE INJURY SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article DE HEXACHLOROETHANE OBSCURANT; TREE FOLIAGE; PHYTOTOXICITY; ZINC DEPOSITION; OPEN-TOP CHAMBERS AB Open-top chambers were used to determine the relationships between a hexachloroethane (HC) obscurant, zinc deposition, and foliar injury of tree species indigenous to military training facilities. Eight eastern U.S. tree species were exposed four times to three exposure regimens (0x, 1x, 2x) of the obscurant, measured as Zn, during the 1990 growing season. Plots received ambient or charcoal-filtered air for comparison purposes. Black locust (Robinia pseudoacacia L.) and black cherry (Prunus serotina Ehrh.) were the most sensitive species, exhibiting significant (p < 0.05) necrotic leaf spot, chlorotic mottle, and marginal necrosis of leaves at the 2x levels throughout the season. Defoliation was also greater (p < 0.05) in exposed vs. unexposed plots. Sugar maple (Acer saccharum Marsh.) injury was different among exposure regimens (p < 0.05) only near the end of the season. Sweet gum (Liquidambar styraciflua L.), eastern white pine (Pinus strobus L.), loblolly pine (Pinus taeda L.), and Virginia pine (Pinus virginiana Mill.) were asymptomatic. Charcoal filtration did not affect severity of symptoms. Zinc deposition was positively correlated (p < 0.05) with most of the symptoms on black locust and black cherry. The HC obscurant in the concentrations used in this study adversely affected these species. C1 USA,CRDEC,SMCCR RST E,ABERDEEN PROVING GROUND,MD 21010. PENN STATE UNIV,DEPT PLANT PATHOL,UNIV PK,PA 16802. RP SADUSKY, MC (reprint author), GEOCENTERS INC,GUNPOWDER BRANCH,POB 68,ABERDEEN PROVING GROUND,MD 21010, USA. NR 15 TC 0 Z9 0 U1 2 U2 2 PU SETAC PRESS PI PENSACOLA PA 1010 NORTH 12TH AVE, PENSACOLA, FL 32501-3370 SN 0730-7268 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD APR PY 1993 VL 12 IS 4 BP 685 EP 694 DI 10.1897/1552-8618(1993)12[685:HOATFI]2.0.CO;2 PG 10 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA KR632 UT WOS:A1993KR63200010 ER PT J AU SJOGREN, MH AF SJOGREN, MH TI THE SUCCESS OF HEPATITIS-A VACCINE SO GASTROENTEROLOGY LA English DT Editorial Material ID VIRUS-VACCINE; IMMUNOGENICITY RP SJOGREN, MH (reprint author), USA,MED RES INST INFECT DIS,FT DETRICK,FREDERICK,MD 21702, USA. NR 18 TC 2 Z9 2 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0016-5085 J9 GASTROENTEROLOGY JI Gastroenterology PD APR PY 1993 VL 104 IS 4 BP 1214 EP 1216 PG 3 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA LM684 UT WOS:A1993LM68400038 PM 8385043 ER PT J AU ANGUEIRA, C KADAKIA, S AF ANGUEIRA, C KADAKIA, S TI EFFECTS OF LARGE VOLUME PARACENTESIS ON PULMONARY-FUNCTION TESTS IN PATIENTS WITH TENSE CIRRHOTIC ASCITES SO GASTROENTEROLOGY LA English DT Meeting Abstract C1 BROOKE ARMY MED CTR,DEPT MED,GASTROENTEROL SERV,FT SAM HOUSTON,TX 78234. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0016-5085 J9 GASTROENTEROLOGY JI Gastroenterology PD APR PY 1993 VL 104 IS 4 SU S BP A871 EP A871 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA KX957 UT WOS:A1993KX95703457 ER PT J AU BOEDEKER, E REID, R BHAGAT, H DALAL, P TACKETT, C LOSONSKY, G NATARO, J EDELMAN, R LEVINE, M AF BOEDEKER, E REID, R BHAGAT, H DALAL, P TACKETT, C LOSONSKY, G NATARO, J EDELMAN, R LEVINE, M TI SAFETY, IMMUNOGENICITY AND EFFICACY IN HUMAN VOLUNTEERS OF BIODEGRADABLE, BIOCOMPATIBLE MICROSPHERES CONTAINING COLONIZATION FACTOR ANTIGEN II (CFA II) AS AN ENTERAL VACCINE AGAINST ENTEROTOXIGENIC ESCHERICHIA-COLI (ETEC) SO GASTROENTEROLOGY LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,WASHINGTON,DC 20307. UNIV MARYLAND,SCH PHARM,BALTIMORE,MD 21201. UNIV MARYLAND,CTR VACCINE DEV,BALTIMORE,MD 21201. NR 0 TC 2 Z9 2 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0016-5085 J9 GASTROENTEROLOGY JI Gastroenterology PD APR PY 1993 VL 104 IS 4 SU S BP A672 EP A672 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA KX957 UT WOS:A1993KX95702668 ER PT J AU CHENEY, CP SHEADONOHUE, T MAYDONOVITCH, CL TRUESDALE, RA BRANTON, P WONG, RKH AF CHENEY, CP SHEADONOHUE, T MAYDONOVITCH, CL TRUESDALE, RA BRANTON, P WONG, RKH TI BIOCHEMICAL-CHANGES IN INTRACELLULAR MUCUS IN PATIENTS WITH GASTRITIS BEFORE AND AFTER ERADICATION OF HELICOBACTER-PYLORI SO GASTROENTEROLOGY LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. USUHS,BETHESDA,MD. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0016-5085 J9 GASTROENTEROLOGY JI Gastroenterology PD APR PY 1993 VL 104 IS 4 SU S BP A681 EP A681 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA KX957 UT WOS:A1993KX95702706 ER PT J AU COHAN, C KADAKIA, S AF COHAN, C KADAKIA, S TI PROSPECTIVE EVALUATION OF PATIENTS WITH POSITIVE FECAL OCCULT BLOOD-TEST AT DIGITAL RECTAL EXAM - IS IT WORTH IT SO GASTROENTEROLOGY LA English DT Meeting Abstract C1 TRIPLER ARMY MED CTR,DEPT MED,HONOLULU,HI 96859. BROOKE ARMY MED CTR,DEPT MED,GASTROENTEROL SERV,SAN ANTONIO,TX. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0016-5085 J9 GASTROENTEROLOGY JI Gastroenterology PD APR PY 1993 VL 104 IS 4 SU S BP A393 EP A393 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA KX957 UT WOS:A1993KX95701560 ER PT J AU FRANCIS, J SHAFFER, R KADAKIA, S CARROUGHER, J AF FRANCIS, J SHAFFER, R KADAKIA, S CARROUGHER, J TI EFFECT OF OMEPRAZOLE ON BARRETT EPITHELIUM AT 3 AND 9 MONTHS OF THERAPY SO GASTROENTEROLOGY LA English DT Meeting Abstract C1 BROOKE ARMY MED CTR,DEPT MED,GASTROENTEROL SERV,FT SAM HOUSTON,TX 78234. NR 0 TC 7 Z9 7 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0016-5085 J9 GASTROENTEROLOGY JI Gastroenterology PD APR PY 1993 VL 104 IS 4 SU S BP A80 EP A80 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA KX957 UT WOS:A1993KX95700317 ER PT J AU GOLDHILL, J SANDERS, K SHEADONOHUE, T SJOGREN, R AF GOLDHILL, J SANDERS, K SHEADONOHUE, T SJOGREN, R TI NEURAL CONTROL OF MUSCLE FUNCTION IN EXPERIMENTAL ILEITIS SO GASTROENTEROLOGY LA English DT Meeting Abstract C1 USUHS,SCH MED,DEPT MED,BETHESDA,MD. WALTER REED ARMY INST RES,WASHINGTON,DC 20307. UNIV RENO,RENO,NV. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0016-5085 J9 GASTROENTEROLOGY JI Gastroenterology PD APR PY 1993 VL 104 IS 4 SU S BP A513 EP A513 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA KX957 UT WOS:A1993KX95702037 ER PT J AU KEPCZYK, T KADAKIA, S AF KEPCZYK, T KADAKIA, S TI PROSPECTIVE EVALUATION OF IRON-DEFICIENCY ANEMIA WITH UPPER ENDOSCOPY AND COLONOSCOPY SO GASTROENTEROLOGY LA English DT Meeting Abstract C1 BROOKE ARMY MED CTR,DEPT MED,GASTROENTEROL SERV,SAN ANTONIO,TX. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0016-5085 J9 GASTROENTEROLOGY JI Gastroenterology PD APR PY 1993 VL 104 IS 4 SU S BP A256 EP A256 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA KX957 UT WOS:A1993KX95701014 ER PT J AU MA, S WONG, RKH KIKENDALL, JW NAIR, PP AF MA, S WONG, RKH KIKENDALL, JW NAIR, PP TI DETECTION OF P53 GENE-MUTATIONS IN EXFOLIATED HUMAN COLONIC EPITHELIAL-CELLS ISOLATED FROM STOOLS OF SUBJECTS UNDERGOING COLONOSCOPY SO GASTROENTEROLOGY LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,GASTROENTEROL SERV,WASHINGTON,DC 20307. USDA,HUMAN NUTR RES CTR,LIPID NUTR LAB,BELTSVILLE,MD 20705. JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,DEPT BIOCHEM,BALTIMORE,MD 21218. JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,DEPT INT HLTH,BALTIMORE,MD 21218. NR 0 TC 4 Z9 4 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0016-5085 J9 GASTROENTEROLOGY JI Gastroenterology PD APR PY 1993 VL 104 IS 4 SU S BP A423 EP A423 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA KX957 UT WOS:A1993KX95701678 ER PT J AU MCQUEEN, C BOEDEKER, E BOLLS, C FLEMING, E CHENEY, C KITOV, S TSENG, LY WOLF, M LE, M BROWN, W AF MCQUEEN, C BOEDEKER, E BOLLS, C FLEMING, E CHENEY, C KITOV, S TSENG, LY WOLF, M LE, M BROWN, W TI ENTERIC IMMUNIZATION WITH NOVASOMES(TM) CONTAINING ADHERENCE PILI FROM A RABBIT ESCHERICHIA-COLI DIARRHEAL STRAIN (RDEC-1) SO GASTROENTEROLOGY LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,WASHINGTON,DC 20307. IGI INC,BEUNA,NJ. VET ADM MED CTR,DENVER,CO 80220. UNIV COLORADO,MED CTR,DENVER,CO 80202. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0016-5085 J9 GASTROENTEROLOGY JI Gastroenterology PD APR PY 1993 VL 104 IS 4 SU S BP A742 EP A742 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA KX957 UT WOS:A1993KX95702946 ER PT J AU MULLETT, C BOLLS, C ACHESON, D FLEMING, E TSENG, LY BOEDEKER, E AF MULLETT, C BOLLS, C ACHESON, D FLEMING, E TSENG, LY BOEDEKER, E TI SERUM AND MUCOSAL IMMUNE-RESPONSE TO SHIGA-LIKE TOXIN 1 (SLT-I) B-SUBUNIT DURING INFECTION OF ADULT-RABBITS WITH ESCHERICHIA-COLI STRAIN RDEC-H19A - A RABBIT MODEL FOR ENTEROHEMORRHAGIC ESCHERICHIA-COLI (EHEC) COLITIS SO GASTROENTEROLOGY LA English DT Meeting Abstract C1 PEDIAT GI SERV WALTER REED,WASHINGTON,DC. IGI INC,NASHUA,NH. NEW ENGLAND MED CTR,BOSTON,MA 02111. WALTER REED ARMY INST RES,WASHINGTON,DC 20307. NR 0 TC 2 Z9 2 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0016-5085 J9 GASTROENTEROLOGY JI Gastroenterology PD APR PY 1993 VL 104 IS 4 SU S BP A750 EP A750 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA KX957 UT WOS:A1993KX95702980 ER PT J AU MURPHY, J SCHAAF, M LUK, G KIKENDALL, JW TANG, D MAYDONOVITCH, C WONG, RKH AF MURPHY, J SCHAAF, M LUK, G KIKENDALL, JW TANG, D MAYDONOVITCH, C WONG, RKH TI MUCOSAL PROLIFERATION IS INCREASED IN PATIENTS WITH ACTIVE ACROMEGALY SO GASTROENTEROLOGY LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. VET ADM MED CTR,DALLAS,TX 75216. NR 0 TC 1 Z9 1 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0016-5085 J9 GASTROENTEROLOGY JI Gastroenterology PD APR PY 1993 VL 104 IS 4 SU S BP A433 EP A433 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA KX957 UT WOS:A1993KX95701718 ER PT J AU MURPHY, J PHILLIPS, R LUK, G TANG, D MAYDONOVITCH, C WONG, RKH AF MURPHY, J PHILLIPS, R LUK, G TANG, D MAYDONOVITCH, C WONG, RKH TI OMEPRAZOLE INDUCED HYPERGASTRINEMIA DOES NOT INCREASE COLONIC MUCOSAL PROLIFERATION SO GASTROENTEROLOGY LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. VET ADM MED CTR,DALLAS,TX 75216. NR 0 TC 3 Z9 3 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0016-5085 J9 GASTROENTEROLOGY JI Gastroenterology PD APR PY 1993 VL 104 IS 4 SU S BP A432 EP A432 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA KX957 UT WOS:A1993KX95701717 ER PT J AU PARKER, A KATZ, N TONEY, M SMITH, T AF PARKER, A KATZ, N TONEY, M SMITH, T TI NUCLEAR HEPATOGRAM - A NUMERIC MEASURE OF LIVER-FUNCTION SO GASTROENTEROLOGY LA English DT Meeting Abstract C1 BROOKE ARMY MED CTR,GASTROENTEROL SERV,FT SAM HOUSTON,TX 78234. BROOKE ARMY MED CTR,DEPT NUCL MED,FT SAM HOUSTON,TX 78234. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0016-5085 J9 GASTROENTEROLOGY JI Gastroenterology PD APR PY 1993 VL 104 IS 4 SU S BP A970 EP A970 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA KX957 UT WOS:A1993KX95703851 ER PT J AU SHAY, S AF SHAY, S TI SOME GERD PATIENTS HAVE INTRAABDOMINAL (IA) HYPERTENSION, A NEW MANOMETRIC FINDING COMPRISED OF PROLONGED EPISODES OF INCREASED IA PRESSURE WITH FREQUENT REFLUX EVENTS (RE) AND SYMPTOMS SO GASTROENTEROLOGY LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0016-5085 J9 GASTROENTEROLOGY JI Gastroenterology PD APR PY 1993 VL 104 IS 4 SU S BP A189 EP A189 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA KX957 UT WOS:A1993KX95700748 ER PT J AU SIOGREN, R COLLETON, C PINEIRO, V GOLDHILL, J SHEADONOHUE, T AF SIOGREN, R COLLETON, C PINEIRO, V GOLDHILL, J SHEADONOHUE, T TI CAPSAICIN EFFECT ON THE MYOELECTRIC AND INFLAMMATORY RESPONSES TO ACUTE RICIN-INDUCED ENTERITIS SO GASTROENTEROLOGY LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,DEPT MED,WASHINGTON,DC 20307. USUHS,BETHESDA,MD. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0016-5085 J9 GASTROENTEROLOGY JI Gastroenterology PD APR PY 1993 VL 104 IS 4 SU S BP A584 EP A584 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA KX957 UT WOS:A1993KX95702320 ER PT J AU SJOGREN, MH INNIS, B REDFIELD, R PERINE, P TICEHURST, J MUSHAHWAR, I DAWSON, G MALIK, I AHMED, A DUNCAN, F LEGTERS, L PURCELL, RH AF SJOGREN, MH INNIS, B REDFIELD, R PERINE, P TICEHURST, J MUSHAHWAR, I DAWSON, G MALIK, I AHMED, A DUNCAN, F LEGTERS, L PURCELL, RH TI ASSESSMENT OF SEROLOGICAL RESPONSES DURING ACUTE AND CONVALESCENT STAGES OF HEPATITIS-E VIRUS-INFECTION USING A NEW IMMUNOASSAY SO GASTROENTEROLOGY LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,WASHINGTON,DC 20307. ABBOTT LABS,N CHICAGO,IL 60064. NIH,BETHESDA,MD 20892. UNIV HLTH SCI,UNIFORMED SERV,BETHESDA,MD. PAKISTAN UNITED STATES LAB SEROEPIDEMIOL,RAWALPINDI,PAKISTAN. RI Ticehurst, John/I-7532-2012 NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0016-5085 J9 GASTROENTEROLOGY JI Gastroenterology PD APR PY 1993 VL 104 IS 4 SU S BP A997 EP A997 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA KX957 UT WOS:A1993KX95703961 ER PT J AU TAI, YH AF TAI, YH TI INDUCTION OF INTESTINAL SECRETION BY ARACHIDONIC-ACID METABOLITES DURING ACUTE ENTERIC INFLAMMATION SO GASTROENTEROLOGY LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0016-5085 J9 GASTROENTEROLOGY JI Gastroenterology PD APR PY 1993 VL 104 IS 4 SU S BP A283 EP A283 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA KX957 UT WOS:A1993KX95701123 ER PT J AU WROBLESKI, C KADAKIA, S KADAKIA, A MEIER, N AF WROBLESKI, C KADAKIA, S KADAKIA, A MEIER, N TI PREVALENCE OF PROXIMAL COLONIC NEOPLASMS IN AVERAGE RISK ASYMPTOMATIC PATIENTS OVER AGE 50 WITH NEGATIVE FECAL OCCULT BLOOD-TESTS AND FLEXIBLE SIGMOIDOSCOPY SO GASTROENTEROLOGY LA English DT Meeting Abstract C1 BROOKE ARMY MED CTR,DEPT MED,INTERNAL MED & GASTROENTEROL SERV,SAN ANTONIO,TX. NR 0 TC 2 Z9 2 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0016-5085 J9 GASTROENTEROLOGY JI Gastroenterology PD APR PY 1993 VL 104 IS 4 SU S BP A1067 EP A1067 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA KX957 UT WOS:A1993KX95704234 ER PT J AU LANDE, RG AF LANDE, RG TI THE VIDEO VIOLENCE DEBATE SO HOSPITAL AND COMMUNITY PSYCHIATRY LA English DT Article ID TELEVISION VIOLENCE; AGGRESSIVE-BEHAVIOR; CHILDRENS TELEVISION; IMPACT; ADOLESCENTS; SUICIDE AB Some researchers and theorists are convinced that graphic scenes of violence on television and in movies are inextricably linked to human aggression. Others insist that a link has not been conclusively established. This paper summarizes scientific studies that have informed these two perspectives. Although many instances of children and adults imitating video violence have been documented, no court has imposed liability for harm allegedly resulting from a video program, an indication that considerable doubt still exists about the role of video violence in stimulating human aggression. The author suggests that a small group of vulnerable viewers are probably more impressionable and therefore more likely to suffer deleterious effects from violent programming. He proposes that research on video violence be narrowed to identifying and describing the vulnerable viewer. RP LANDE, RG (reprint author), WALTER REED ARMY MED CTR,OUTPATIENT PSYCHIAT SERV,WASHINGTON,DC 20012, USA. NR 42 TC 12 Z9 13 U1 0 U2 2 PU AMER PSYCHIATRIC ASSOCIATION PI WASHINGTON PA 1400 K ST NW, WASHINGTON, DC 20005 SN 0022-1597 J9 HOSP COMMUNITY PSYCH PD APR PY 1993 VL 44 IS 4 BP 347 EP 351 PG 5 WC Public, Environmental & Occupational Health; Psychiatry SC Public, Environmental & Occupational Health; Psychiatry GA KV461 UT WOS:A1993KV46100008 PM 8462940 ER PT J AU MCKIM, HL CASSELL, EA LAPOTIN, PJ AF MCKIM, HL CASSELL, EA LAPOTIN, PJ TI WATER-RESOURCE MODELING USING REMOTE-SENSING AND OBJECT-ORIENTED SIMULATION .4. SO HYDROLOGICAL PROCESSES LA English DT Article DE WATER RESOURCE MODELING; REMOTE SENSING; OBJECT-ORIENTED SIMULATION AB Remote sensing technology has matured significantly over the past decade. Operational satellites provide reliable, periodic coverage for all areas of the Earth. Data from these satellites are in a digital format that provides enhanced flexibility in hydrological modelling. Considerable advances in acquiring hydrological data from airborne and in situ sensors have also been achieved. Additionally, data from non-traditional remote sources such as weather radar from which spatial and temporal rainfall rates may be estimated are widely available. These new data acquisition capabilities have been paralleled by equal advancements in digital array processing and geographic information systems, which allow the effective extraction of both temporal and spatial information. This paper examines the use of object-oriented programming techniques to create dynamic hydrological models, and explores their potential to receive real and near real-time data from remote sensors as input to improve hydrological forecasting. In particular, the COE SSARR model is used to illustrate how an established hydrological model may be adapted to create a dynamic object model. RP MCKIM, HL (reprint author), USA,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 0 TC 8 Z9 8 U1 0 U2 0 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0885-6087 J9 HYDROL PROCESS JI Hydrol. Process. PD APR-JUN PY 1993 VL 7 IS 2 BP 153 EP 165 DI 10.1002/hyp.3360070206 PG 13 WC Water Resources SC Water Resources GA KZ958 UT WOS:A1993KZ95800005 ER PT J AU MILLER, LE LEE, JS TORRIERI, DJ AF MILLER, LE LEE, JS TORRIERI, DJ TI FREQUENCY-HOPPING SIGNAL-DETECTION USING PARTIAL BAND COVERAGE SO IEEE TRANSACTIONS ON AEROSPACE AND ELECTRONIC SYSTEMS LA English DT Letter AB The performance of a channelized radiometer in detecting a frequency-hopping signal is analyzed for a variable number of parallel radiometers not necessarily covering the entire hopping band. The full band may not be covered because of an attempt to avoid interfering signals, limited radiometer resources, lack of knowledge of the band frequency location, or combinations of these factors. The analysis provides for calculation of the value of the signal-to-noise ratio (SNR) required to achieve a given probability of detection for a specified false-alarm rate, assuming an observation interval equivalent to N hops using either a fixed or a moving observation window. The dependence of the probability of detection on a misalignment of the detector observation intervals with the hop transitions is also analyzed. Numerical results are presented which indicate 1) the required SNR is primarily a function of the observation time; 2) the performance of the channelized radiometer is more sensitive to the number of radiometer channels than to the fraction of the hopping band that is covered, 3) time misalignment aids detection when only a portion of the band is covered by radiometers, for high SNR, and 4) a fixed observation interval is preferable unless it is comparable to the duration of the hopping signal. Applied to a typical slow-hopping VHF radio, the results imply that a 150 hop transmission can be detected by a channelized radiometer covering half the hopping band when the SNR is about 2 dB. C1 USA,SURVIVABIL MANAGEMENT OFF,ADELPHI,MD 20783. RP MILLER, LE (reprint author), JS LEE ASSOCIATES INC,451 HUNGERFORD DR,SUITE 609,ROCKVILLE,MD 20850, USA. NR 16 TC 18 Z9 21 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9251 J9 IEEE T AERO ELEC SYS JI IEEE Trans. Aerosp. Electron. Syst. PD APR PY 1993 VL 29 IS 2 BP 540 EP 553 DI 10.1109/7.210091 PG 14 WC Engineering, Aerospace; Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA KY174 UT WOS:A1993KY17400025 ER PT J AU ZHAO, JH BURKE, T LARSON, D WEINER, M CHIN, A BALLINGALL, JM YU, TH AF ZHAO, JH BURKE, T LARSON, D WEINER, M CHIN, A BALLINGALL, JM YU, TH TI SENSITIVE OPTICAL GATING OF REVERSE-BIASED ALGAAS/GAAS OPTOTHYRISTORS FOR PULSED POWER SWITCHING APPLICATIONS SO IEEE TRANSACTIONS ON ELECTRON DEVICES LA English DT Article ID GAAS AB A heterojunction-based optothyristor has been fabricated and tested with biasing field intensity up to 34 kV/cm for pulsed power applications. It is observed that the reverse-biased optothyristor can even be triggered by a light-emitting diode (LED) of a few microwatts power and more than 500 times reduction in the required LED power for triggering has been observed when compared to bulk photoconductive switches. The optothyristor, however, does not turn on under similar triggering conditions if bias polarity is changed. The sensitive optical gating of the reverse-biased optothyristor is due to i) the wider bandgap AlGaAs optical window action, ii) the doped n and p layers that act as electron and hole guns which emit carriers into the SI-GaAs, and iii) the reverse-biased n+-p and p+-n junctions which provide large tunneling current and help in collecting photo-generated electrons and holes, respectively. The turn-on delay time under reverse bias has also been studied as a function of the LED power (P(op)) and is found to depend inversely proportional to the square root of P(op). The possibility of improving the switching efficiency by superimposing semiconductor laser pulse on a constant lower level background illumination has also been demonstrated. C1 USA,LABCOM,ETD LAB,FT MONMOUTH,NJ 07703. GE,ELECTR LAB,SYRACUSE,NY 13221. RP ZHAO, JH (reprint author), RUTGERS STATE UNIV,DEPT ELECT & COMP ENGN,POB 909,PISCATAWAY,NJ 08855, USA. NR 20 TC 7 Z9 7 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9383 J9 IEEE T ELECTRON DEV JI IEEE Trans. Electron Devices PD APR PY 1993 VL 40 IS 4 BP 817 EP 823 DI 10.1109/16.202796 PG 7 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA KR138 UT WOS:A1993KR13800019 ER PT J AU ALVING, CR AF ALVING, CR TI LIPOPOLYSACCHARIDE, LIPID-A, AND LIPOSOMES CONTAINING LIPID-A AS IMMUNOLOGICAL ADJUVANTS SO IMMUNOBIOLOGY LA English DT Article ID MALARIA SPOROZOITE ANTIGEN; MACROPHAGE IA EXPRESSION; NONIONIC BLOCK COPOLYMERS; TUMOR NECROSIS FACTOR; HERPES-SIMPLEX VIRUS; T-CELL ACTIVITY; BACTERIAL LIPOPOLYSACCHARIDE; IMMUNOBIOLOGICAL ACTIVITIES; STRUCTURAL REQUIREMENTS; MONOCLONAL-ANTIBODIES AB Numerous studies have demonstrated that most or all of the potent adjuvant activity of Gram-negative bacterial endotoxin resides in the lipid A moiety of lipopolysaccharide (LPS). Synthetic analogues of lipid A have provided insights into structure-activity relationships. Several cellular mechanisms of LPS and lipid A adjuvant activities have been identified. Activation of macrophages by LPS or lipid A results in cytokine secretions that enhance the immune response. LPS and lipid A cause recruitment of antigen-presenting cells, particularly macrophages. Liposomes containing lipid A serve as an in vivo adjuvant to recruit increased numbers of macrophages. Liposomal lipid A that has been phagocytized by cultured macrophages also serves as an <> to cause increased immunologic presentation of liposomal antigen by the macrophages to specific T lymphocytes. Lipid A can abolish suppressor T cell activity, resulting in increased immune responses to polysaccharide antigens. Upon combination of lipid A or lipid A analogues with nonionic block polymers, modulation of murine antibody isotypes can be achieved with antibodies against a variety of antigens in vivo. Liposomes containing monophosphoryl lipid A (MPL) have been utilized in a phase I clinical trial of a proposed malaria vaccine in humans. The liposomal malaria vaccine resulted in very high levels of antibodies against the malarial antigen, and despite the presence of huge amounts of MPL (up to 2.2 mg), the liposomal lipid A was nonpyrogenic and safe for use in humans. Lipid A and lipid A analogues, and liposomes or other carriers containing lipid A, have shown considerable promise both as adjuvants for immunization of animals and for human vaccines. RP ALVING, CR (reprint author), WALTER REED ARMY INST RES,DEPT MEMBRANE BIOCHEM,WASHINGTON,DC 20307, USA. NR 81 TC 130 Z9 133 U1 1 U2 5 PU GUSTAV FISCHER VERLAG PI JENA PA VILLENGANG 2, D-07745 JENA, GERMANY SN 0171-2985 J9 IMMUNOBIOLOGY JI Immunobiology PD APR PY 1993 VL 187 IS 3-5 BP 430 EP 446 PG 17 WC Immunology SC Immunology GA LB467 UT WOS:A1993LB46700019 PM 8330907 ER PT J AU LUDWIG, GV IACONOCONNORS, LC AF LUDWIG, GV IACONOCONNORS, LC TI INSECT-TRANSMITTED VERTEBRATE VIRUSES - FLAVIVIRIDAE SO IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL LA English DT Review DE FLAVIVIRIDAE; ECOLOGY; MOSQUITO; TICK; REVIEW; CELL CULTURE ID JAPANESE ENCEPHALITIS-VIRUS; YELLOW-FEVER VIRUS; RECOMBINANT VACCINIA VIRUS; ATTENUATED DENGUE-4 VIRUSES; PRIMARY KIDNEY-CELLS; BACULOVIRUS EXPRESSION VECTORS; CULTURED MOSQUITO CELLS; RHESUS LUNG-CELLS; FULL-LENGTH CDNA; WEST NILE VIRUS AB The Flaviviridae include almost 70 viruses, nearly half of which have been associated with human disease. These viruses are among the most important arthropod-borne viruses worldwide and include dengue, yellow fever, and Japanese encephalitis viruses. Morbidity and mortality caused by these viruses vary, but collectively they account for millions of encephalitis, hemorrhagic fever, arthralgia, rash, and fever cases per year. Most of the members of this family are transmitted between vertebrate hosts by arthropod vectors, most commonly mosquitoes or ticks. Transmission cycles can be simple or complex depending on the hosts, vectors, the virus, and the environmental factors affecting both hosts and viruses. Replication of virus in invertebrate hosts does not seem to result in any significant pathology, which suggests a close evolutionary relationship between virus and vector. Another example of this relationship is the ability of these viruses to grow in invertebrate cell culture, where replication usually results in a steady state, persistent infection, often without cytopathic effect. Yields of virus from insect cell culture vary but are generally similar to yields in vertebrate cells. Replication kinetics are comparable between insect and vertebrate cell fines, despite differences in incubation temperature. Both vertebrate and insect cell culture systems continue to play a significant role in flavivirus isolation and the diagnosis of disease caused by these agents. Additionally, these culture systems permit the study of flavivirus attachment, penetration, replication, and release from cells and have been instrumental in the production and characterization of live-attenuated vaccines. Both vertebrate and insect cell culture systems will continue to play a significant role in basic and applied flavivirus research in the future. RP LUDWIG, GV (reprint author), USA,MED RES INST INFECT DIS,DIV VIROL,FT DETRICK,FREDERICK,MD 21702, USA. NR 118 TC 5 Z9 5 U1 1 U2 8 PU SOC IN VITRO BIOLOGY PI UPPER MARLBORO PA 9315 LARGO DR W #255, UPPER MARLBORO, MD 20774-4755 SN 1071-2690 J9 IN VITRO CELL DEV-AN JI In Vitro Cell. Dev. Biol.-Anim. PD APR PY 1993 VL 29A IS 4 BP 296 EP 309 PG 14 WC Cell Biology; Developmental Biology SC Cell Biology; Developmental Biology GA LD071 UT WOS:A1993LD07100011 ER PT J AU FRIES, LF WAAG, DM WILLIAMS, JC AF FRIES, LF WAAG, DM WILLIAMS, JC TI SAFETY AND IMMUNOGENICITY IN HUMAN VOLUNTEERS OF A CHLOROFORM-METHANOL RESIDUE VACCINE FOR Q-FEVER SO INFECTION AND IMMUNITY LA English DT Article ID I COXIELLA-BURNETII; PHASE-I; IMMUNITY; MICE; LIPOPOLYSACCHARIDES; SUSCEPTIBILITY; VIRULENCE; ABATTOIRS; CELLS AB Current Q fever vaccines, consisting of Formalin-inactivated phase I whole Coxiella burnetii, are highly efficacious, in preventing disease in high-risk settings but are associated with a risk of unacceptable local reactions in previously immune individuals and require cumbersome preliminary immunologic evaluation of potential vaccinees. A vaccine prepared from the residue of chloroform-methanol extraction of phase I Henzerling strain C. burnetii (CMR) has been shown to be less reactogenic but still immunogenic and protective in small animals and sheep. In a placebo-controlled trial, we immunized 35 healthy adults unscreened for markers of prior C. burnetii immunity with a single subcutaneous CMR dose of 30, 60, 120, or 240 mug. None of those receiving the 30- or 600 mug CMR dose and none of the placebo recipients experienced any adverse effects. Five of 15 120-mug dose CMR recipients complained of transient discomfort in the inoculated arm; erythema or induration of greater-than-or-equal-to 100 mm2 was noted in three and four, respectively, and two had malaise and low-grade fever (< 101-degrees-F, orally). No 240-mug dose vaccinee reported limb discomfort, but 7 of 10 had erythema and/or induration of greater-than-or-equal-to 100 mm2 (P < 0.001 versus placebo). Two reported malaise, and one had low-grade fever. All adverse effects were self-limited. Serum immunoglobulin M responses were optimally detected with CMR antigen and occurred in 50, 60, 73, and 90% of recipients of the 30-, 60-, 120-, and 240-mug doses, respectively; results with phase I whole-cell antigen were similar. Serum immunoglobulin G responses were best detected with phase II antigen and were seen in 20, 20, and 40% of those receiving the 60-, 120-, and 240-mug doses, respectively. Peripheral blood T-cell proliferative responses to (C. burnetii recall antigens were transient and of low magnitude but were seen with CMR antigen in 33% of 120-mug dose recipients and 40% of 240-mug dose recipients. Data from this study and those from comparative-efficacy trials in primates should provide the basis for field trials of the CMR vaccine. C1 USA,MED RES INST INFECT DIS,FREDERICK,MD 21702. US FDA,CTR BIOL EVALUAT & RES,DIV BIOL INVEST NEW DRUGS,BETHESDA,MD 20892. RP FRIES, LF (reprint author), JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,DEPT INT HLTH,CTR IMMUNIZA RES,BALTIMORE,MD 21205, USA. NR 34 TC 28 Z9 31 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD APR PY 1993 VL 61 IS 4 BP 1251 EP 1258 PG 8 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA KU320 UT WOS:A1993KU32000012 PM 8454328 ER PT J AU KOLB, RA STEKLER, HO AF KOLB, RA STEKLER, HO TI ARE ECONOMIC FORECASTS SIGNIFICANTLY BETTER THAN NAIVE PREDICTIONS - AN APPROPRIATE TEST SO INTERNATIONAL JOURNAL OF FORECASTING LA English DT Note DE ERROR COMPARISONS; HYPOTHESIS TEST; NAIVE MODEL AB Most forecast evaluations do not test whether the predictions are statistically significantly better than naive forecasts. This note describes how an existing test can be used to test the hypothesis that predictions are superior to naive forecasts. C1 NATL DEF UNIV,IND COLL ARMED FORCES,FT LESLEY J MCNAIR,WASHINGTON,DC 20319. US MIL ACAD,DEPT MATH,W POINT,NY 10996. NR 4 TC 10 Z9 10 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0169-2070 J9 INT J FORECASTING JI Int. J. Forecast. PD APR PY 1993 VL 9 IS 1 BP 117 EP 120 DI 10.1016/0169-2070(93)90059-V PG 4 WC Economics; Management SC Business & Economics GA LF422 UT WOS:A1993LF42200017 ER PT J AU GHOSN, LJ CALOMINO, AM BREWER, DN AF GHOSN, LJ CALOMINO, AM BREWER, DN TI ANALYTICAL STRESS INTENSITY SOLUTION FOR THE STABLE POISSON LOADED SPECIMEN SO INTERNATIONAL JOURNAL OF FRACTURE LA English DT Article AB An analytical calibration of the Stable Poisson Loaded (SPL) specimen is presented. The specimen configuration is similar to the ASTM E-561 compact-tension specimen with displacement controlled wedge loading used for R-curve determination. The crack mouth opening displacements (CMOD's) are produced by the diametral expansion of an axially compressed cylindrical pin located in the wake of a machined notch. Due to the unusual loading configuration, a three-dimensional finite element analysis was performed with gap elements simulating the contact between the pin and specimen. In this report, stress intensity factors, CMOD's, and crack displacement profiles, are reported for different crack lengths and different contacting conditions. It was concluded that the computed stress intensity factor decreases sharply with increasing crack length thus making the SPL specimen configuration attractive for fracture testing of brittle, high modulus materials. C1 USA,LEWIS RES CTR,RES LAB,CLEVELAND,OH 44135. NASA,LEWIS RES CTR,CLEVELAND,OH 44135. RP GHOSN, LJ (reprint author), SVERDRUP TECHNOL INC,LEWIS RES CTR GRP,BROOKPARK,OH 44142, USA. NR 12 TC 1 Z9 1 U1 0 U2 1 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 0376-9429 J9 INT J FRACTURE JI Int. J. Fract. PD APR 1 PY 1993 VL 60 IS 3 BP 209 EP 220 DI 10.1007/BF00012509 PG 12 WC Materials Science, Multidisciplinary; Mechanics SC Materials Science; Mechanics GA LF651 UT WOS:A1993LF65100002 ER PT J AU BARATTA, FI AF BARATTA, FI TI WIDE-RANGE STRESS INTENSITY FACTORS FOR A STRAIGHT-FRONTED EDGE CRACK IN A 3-POINT BEND, ROUND BAR SPECIMEN SO INTERNATIONAL JOURNAL OF FRACTURE LA English DT Article ID CIRCULAR BAR RP BARATTA, FI (reprint author), USA,RES LAB,WATERTOWN,MA 02172, USA. NR 12 TC 3 Z9 3 U1 0 U2 0 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 0376-9429 J9 INT J FRACTURE JI Int. J. Fract. PD APR 1 PY 1993 VL 60 IS 3 BP R59 EP R63 DI 10.1007/BF00012518 PG 5 WC Materials Science, Multidisciplinary; Mechanics SC Materials Science; Mechanics GA LF651 UT WOS:A1993LF65100010 ER PT J AU SIGGINS, BA HENDRICKS, BW AF SIGGINS, BA HENDRICKS, BW TI FORENSIC DRUG CHEMISTRY - A COOPERATIVE PROGRAM SO JOURNAL OF CHEMICAL EDUCATION LA English DT Article C1 ZAMA AMER HIGH SCH,CAMP ZAMA,JAPAN. RP SIGGINS, BA (reprint author), USA,CRIMINAL INVEST LAB PACIFIC,SAN FRANCISCO,CA 96343, USA. NR 5 TC 3 Z9 3 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0021-9584 J9 J CHEM EDUC JI J. Chem. Educ. PD APR PY 1993 VL 70 IS 4 BP 312 EP 314 PG 3 WC Chemistry, Multidisciplinary; Education, Scientific Disciplines SC Chemistry; Education & Educational Research GA KZ720 UT WOS:A1993KZ72000023 ER PT J AU WOLF, MK TAYLOR, DN BOEDEKER, EC HYAMS, KC MANEVAL, DR LEVINE, MM TAMURA, K WILSON, RA ECHEVERRIA, P AF WOLF, MK TAYLOR, DN BOEDEKER, EC HYAMS, KC MANEVAL, DR LEVINE, MM TAMURA, K WILSON, RA ECHEVERRIA, P TI CHARACTERIZATION OF ENTEROTOXIGENIC ESCHERICHIA-COLI ISOLATED FROM UNITED-STATES TROOPS DEPLOYED TO THE MIDDLE-EAST SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID CELL CHOLERA VACCINE; COLONIZATION FACTORS; TRAVELERS DIARRHEA; MILITARY PERSONNEL; FIMBRIAL ADHESINS; SURFACE-ANTIGENS; CHILDREN; DISEASE; PCF8775; PURIFICATION AB Enterotoxigenic Escherichia coli (ETEC) was a common cause of traveler's diarrhea in U.S. soldiers in the Middle East in 1989 and 1990. To determine which bacterial components would be useful in a vaccine, potential protective antigens (toxin, colonization factor antigen [CFA], and serotype) from 189 ETEC isolates were examined. Nearly half of the isolates expressed both ETEC toxins, 39% had only heat-stable enterotoxin (ST), and 17% had heat-labile enterotoxin (LT). CFA/I was the least common colonization factor antigen (11%), CFA/II was common (34%), as was CFA/IV (31%), and 24% expressed none of these CFAs. Fifty-seven O:H serotypes were found. Serotype 06:H16 was the most common, occurring in 29% of the ETEC isolates, usually with LT-ST and CFA/II. Generally, CFA/II was associated with expression of both toxins, CFA/IV was associated with expression of ST, and none of the CFAs was routinely found with LT. We conclude that ETEC from soldiers in the Middle East expressed a variety of antigens and that an effective vaccine will require multiple protective antigens. C1 WALTER REED ARMY INST RES,DEPT ENTER INFECT,WASHINGTON,DC 20307. USN,MED RES INST,BETHESDA,MD 20814. UNIV MARYLAND,CTR VACCINE DEV,DIV GEOG MED,BALTIMORE,MD 21201. NATL INST HLTH,TOKYO 141,JAPAN. PENN STATE UNIV,UNIV PK,PA 16802. ARMED FORCES RES INST MED SCI,BANGKOK,THAILAND. RP WOLF, MK (reprint author), WALTER REED ARMY INST RES,DEPT GASTROENTEROL,WASHINGTON,DC 20307, USA. NR 33 TC 60 Z9 61 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD APR PY 1993 VL 31 IS 4 BP 851 EP 856 PG 6 WC Microbiology SC Microbiology GA KT445 UT WOS:A1993KT44500017 PM 8463396 ER PT J AU LIN, RR PALAZZOLO, AB KASCAK, AF MONTAGUE, GT AF LIN, RR PALAZZOLO, AB KASCAK, AF MONTAGUE, GT TI ELECTROMECHANICAL SIMULATION AND TESTING OF ACTIVELY CONTROLLED ROTORDYNAMIC SYSTEMS WITH PIEZOELECTRIC ACTUATORS SO JOURNAL OF ENGINEERING FOR GAS TURBINES AND POWER-TRANSACTIONS OF THE ASME LA English DT Article; Proceedings Paper CT 36TH INTERNATIONAL GAS TURBINE AND AEROENGINE CONGRESS AND EXPOSITION CY JUN 03-06, 1991 CL ORLANDO, FL AB Past research on this subject has treated Piezoelectric actuators as ideal devices that have tip displacements proportional to their input voltages, at any instant in time. This assumption neglected phase lag and amplitude change at high frequencies. This characteristic of any actuator may lead to coupled control system-structural system instability that limits the amount of active stiffness or active damping that can be obtained. The paper presents a method for simulating the coupled ''electromechanical'' system to predict rotordynamic stability and unbalance response along with control system stability. The piezoelectric actuators and their amplifiers are represented as equivalent linear electrical circuits. The electromechanical system modeling approach is utilized to correlate test results from a double overhung rotor rig at NASA Lewis. The test results also show the effectiveness of the control system for suppressing the unbalance response of two modes using active stiffness and active damping. C1 TEXAS A&M UNIV SYST,COLL STN,TX 77843. USA,NASA LEWIS,CLEVELAND,OH 44135. SVERDRUP,NASA LEWIS,CLEVELAND,OH 44135. NR 20 TC 9 Z9 9 U1 1 U2 3 PU ASME-AMER SOC MECHANICAL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 SN 0742-4795 J9 J ENG GAS TURB POWER JI J. Eng. Gas. Turbines Power-Trans. ASME PD APR PY 1993 VL 115 IS 2 BP 324 EP 335 DI 10.1115/1.2906712 PG 12 WC Engineering, Mechanical SC Engineering GA KZ489 UT WOS:A1993KZ48900017 ER PT J AU HAO, OJ PHULL, KK CHEN, JM DAVIS, AP MALONEY, SW AF HAO, OJ PHULL, KK CHEN, JM DAVIS, AP MALONEY, SW TI FACTORS AFFECTING WET AIR OXIDATION OF TNT RED WATER - RATE STUDIES SO JOURNAL OF HAZARDOUS MATERIALS LA English DT Article ID SUBSTITUTED PHENOLS; KINETICS AB Preliminary experiments have demonstrated wet air oxidation (WAO) to be feasible for TNT red water treatment. This paper presents the results of rate studies for the evaluation of temperature, partial oxygen pressure P(O2), initial red water concentration, salt concentration, and catalyst/initiator addition on WAO performance. Results show the WAO efficiency to be a function primarily of temperature, and to a lesser extent, the initial P(O2) A significant initial (usually <5 minutes) rapid reduction in total organic carbon (TOC) or chemical oxygen demand (COD) is observed in all experiments. The extent of reduction varies with the experimental conditions: the harsher the condition, the higher the initial reduction. At lower temperatures, the subsequent WAO of red water proceeds as a first-order reaction with respect to TOC or COD. Under harsher temperature conditions, the reaction follows two distinct first-order phases. High salt concentrations (Na2SO4 and NaNO3) slightly enhanced the overall oxidation. Addition of Cu(II) as a catalyst results in rate enhancement. Several issues regarding application of WAO are discussed. C1 USA,TOX & HAZARDOUS MAT AGCY,ABERDEEN PROVING GROUND,MD 21010. USA,CORPS ENGINEERS,CONSTRUCT ENGN RES LAB,CHAMPAIGN,IL 61826. RP HAO, OJ (reprint author), UNIV MARYLAND,DEPT CIVIL ENGN,COLL PK,MD 20742, USA. RI DAVIS, ALLEN/F-1066-2017 OI DAVIS, ALLEN/0000-0001-7818-1890 NR 21 TC 19 Z9 22 U1 0 U2 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3894 J9 J HAZARD MATER JI J. Hazard. Mater. PD APR PY 1993 VL 34 IS 1 BP 51 EP 68 DI 10.1016/0304-3894(93)87003-C PG 18 WC Engineering, Environmental; Engineering, Civil; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA LD290 UT WOS:A1993LD29000003 ER PT J AU FRIPP, JB DIPLAS, P AF FRIPP, JB DIPLAS, P TI SURFACE SAMPLING IN GRAVEL STREAMS SO JOURNAL OF HYDRAULIC ENGINEERING-ASCE LA English DT Article AB The accuracy of studies concerning the characteristics of gravel-bed waterways is often dependent upon the techniques used to sample and quantify the material found on the channel boundary. Due to the vertical stratification present in the riverbed, the use of sampling techniques that remove only the particles within a thin surface layer is often necessary. Attributes of clay and grid sampling are considered in the present work. Criteria for determining the minimum sample size for a desirable level of accuracy are also presented. Many of the current surface sampling techniques truncate either the upper or lower size range of particles. Truncation of part of a size distribution not only limits the available information, but can also bias the rest of the distribution. The present work rectifies this problem by proposing the use of a hybrid technique that can sample the entire size range of either dry or submerged bed material. Results of field tests that utilize this new method are described in detail. C1 VIRGINIA POLYTECH INST & STATE UNIV,DEPT MAGNETISM,BLACKSBURG,VA 24061. RP FRIPP, JB (reprint author), USA,CORPS ENGN,HUNTINGTON,WV 25701, USA. RI Lucas, Elizabeth/E-2733-2010 NR 16 TC 68 Z9 68 U1 0 U2 9 PU ASCE-AMER SOC CIVIL ENGINEERS PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-9429 J9 J HYDRAUL ENG-ASCE JI J. Hydraul. Eng.-ASCE PD APR PY 1993 VL 119 IS 4 BP 473 EP 490 DI 10.1061/(ASCE)0733-9429(1993)119:4(473) PG 18 WC Engineering, Civil; Engineering, Mechanical; Water Resources SC Engineering; Water Resources GA KU156 UT WOS:A1993KU15600003 ER PT J AU HILL, J COCKERELL, CJ AF HILL, J COCKERELL, CJ TI HISTOLOGIC AND CLINICAL FINDINGS IN CUTANEOUS MERKEL CELL-CARCINOMA SO JOURNAL OF INVESTIGATIVE DERMATOLOGY LA English DT Meeting Abstract C1 BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234. UNIV TEXAS,SW MED CTR,DALLAS,TX 75230. NR 0 TC 0 Z9 0 U1 0 U2 0 PU BLACKWELL SCIENCE INC PI CAMBRIDGE PA 238 MAIN ST, CAMBRIDGE, MA 02142 SN 0022-202X J9 J INVEST DERMATOL JI J. Invest. Dermatol. PD APR PY 1993 VL 100 IS 4 BP 544 EP 544 PG 1 WC Dermatology SC Dermatology GA KW395 UT WOS:A1993KW39500637 ER PT J AU SMITH, KJ MCCARTHY, W SKELTON, H LEDSKY, R YEAGER, J WAGNER, K AF SMITH, KJ MCCARTHY, W SKELTON, H LEDSKY, R YEAGER, J WAGNER, K TI HYPEREOSINOPHILIA AND HIV-1 DISEASE - A PREDICTOR OF PROLONGED SURVIVAL IN LATE STAGE DISEASE SO JOURNAL OF INVESTIGATIVE DERMATOLOGY LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES, WASHINGTON, DC 20307 USA. ARMED FORCES INST PATHOL, WASHINGTON, DC 20306 USA. NATL NAVAL MED CTR, DEPT DERMATOL, BETHESDA, MD 20814 USA. HENRY M JACKSON FDN, BETHESDA, MD USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU BLACKWELL SCIENCE INC PI CAMBRIDGE PA 238 MAIN ST, CAMBRIDGE, MA 02142 SN 0022-202X J9 J INVEST DERMATOL JI J. Invest. Dermatol. PD APR PY 1993 VL 100 IS 4 BP 575 EP 575 PG 1 WC Dermatology SC Dermatology GA KW395 UT WOS:A1993KW39500819 ER PT J AU ROTHWELL, SW DEAL, CC PINTO, J WRIGHT, DG AF ROTHWELL, SW DEAL, CC PINTO, J WRIGHT, DG TI AFFINITY PURIFICATION AND SUBCELLULAR-LOCALIZATION OF KINESIN IN HUMAN NEUTROPHILS SO JOURNAL OF LEUKOCYTE BIOLOGY LA English DT Article DE NEUTROPHILS; KINESIN; MICROTUBULES; PEPTIDES; GRANULES ID ACTIN-FILAMENTS; LIGHT-CHAINS; MICROTUBULES; INVITRO; MYOSIN; HEAVY; ANTIBODIES; TRANSPORT; MOTILITY; GRANULES AB Studies of granule-microtubule interactions in human neutrophils have suggested that mechanochemical ATPases such as kinesin or dynein may play a role in granule mobilization during neutrophil activation by inflammatory signals. In this study we show that proteins extracted from the surface of neutrophil granules, found previously to contain microtubule-dependent ATPase activity, caused microtubules polymerized from phosphocellulose-purified rat brain tubulin to move across glass slides. Antibodies were generated against peptides based on two regions of the amino acid sequence of Drosophila kinesin: the ATPase active site (amino acids 86-99) in the head of the kinesin heavy chain and the tail of the heavy chain (residues 913-933). These antibodies were found to recognize kinesin in rat brain extracts as well as kinesin-like polypeptides in extracts of human neutrophils. Furthermore, when used in immunoaffinity chromatography, these antibodies permitted the isolation of a protein from neutrophil granule extracts that was recognized by Drosophila kinesin antibodies. Subcellular localization by immunofluorescence microscopy showed this protein to be associated principally with the cytoplasmic granules of neutrophils. C1 WALTER REED ARMY INST RES,DEPT HEMATOL,WASHINGTON,DC 20307. WALTER REED ARMY INST RES,DEPT BACTERIAL DIS,WASHINGTON,DC 20307. NR 24 TC 14 Z9 14 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0741-5400 J9 J LEUKOCYTE BIOL JI J. Leukoc. Biol. PD APR PY 1993 VL 53 IS 4 BP 372 EP 380 PG 9 WC Cell Biology; Hematology; Immunology SC Cell Biology; Hematology; Immunology GA LB373 UT WOS:A1993LB37300004 PM 8482917 ER PT J AU RUDD, GW AF RUDD, GW TI SHIFTING LINES IN THE SAND - FINNIE,DH SO JOURNAL OF MILITARY HISTORY LA English DT Book Review RP RUDD, GW (reprint author), US MIL ACAD,W POINT,NY 10996, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU VIRGINIA MILITARY INST PI LEXINGTON PA LEXINGTON, VA 24450 SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD APR PY 1993 VL 57 IS 2 BP 360 EP 361 DI 10.2307/2944087 PG 2 WC History SC History GA KY270 UT WOS:A1993KY27000033 ER PT J AU SATTERFIELD, MJ YASUMURA, K ABREU, SH AF SATTERFIELD, MJ YASUMURA, K ABREU, SH TI RETRO RUNNER WITH ISCHIAL TUBEROSITY ENTHESOPATHY SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Article DE RETRO RUNNING; ENTHESOPATHY; OVERUSE INJURIES AB In reviewing the literature, no studies were found reporting the use of retro running on flat and hilly terrain, which elicited enthesopathy (stress reaction) at the ischial tuberosity. Therefore, this case study of an atypical enthesopathy condition warrants careful scrutiny in order to generate future research. This case study describes the clinical management of a female runner with bilateral patellofemoral pain who self-initiated a program of backward running and stationary bicycling after reading an article about retro running in a runners' magazine. She subsequently developed ischial tuberosity enthesopathy verified by scintigraphy (bone scan). Her symptoms gradually resolved with physical therapy intervention. Eventually, she was able to forward jog 2 miles on flat surfaces without complaint of pain but did not resume retro running. This case not only suggests the need for further research in retro running kinetics and kinematics but highlights the proactive role health professionals must assume in injury prevention. RP SATTERFIELD, MJ (reprint author), WOMACK ARMY MED CTR,PHYS THERAPY SECT,FT BRAGG,NC 28307, USA. NR 0 TC 3 Z9 3 U1 0 U2 2 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0190-6011 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD APR PY 1993 VL 17 IS 4 BP 191 EP 194 PG 4 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA KU113 UT WOS:A1993KU11300005 PM 8467344 ER PT J AU ASCHER, DP SHOUPE, BA MAYBEE, D FISCHER, GW AF ASCHER, DP SHOUPE, BA MAYBEE, D FISCHER, GW TI PERSISTENT CATHETER-RELATED BACTEREMIA - CLEARANCE WITH ANTIBIOTICS AND UROKINASE SO JOURNAL OF PEDIATRIC SURGERY LA English DT Article DE CENTRAL VENOUS CATHETER-RELATED BACTEREMIA; UROKINASE ID ADHERENCE; CHILDREN; SURFACES C1 UNIFORMED SERV UNIV HLTH SCI,DEPT PEDIAT INFECT DIS,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,DEPT PEDIAT HEMATOL ONCOL,WASHINGTON,DC 20307. NR 9 TC 25 Z9 25 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0022-3468 J9 J PEDIATR SURG JI J. Pediatr. Surg. PD APR PY 1993 VL 28 IS 4 BP 627 EP 629 DI 10.1016/0022-3468(93)90675-B PG 3 WC Pediatrics; Surgery SC Pediatrics; Surgery GA KY514 UT WOS:A1993KY51400022 PM 8483081 ER PT J AU WONG, MT CALVERLEY, MJ NAGY, WW AF WONG, MT CALVERLEY, MJ NAGY, WW TI REMOVABLE PARTIAL DENTURE FRAMEWORK TRY-IN SO JOURNAL OF PROSTHETIC DENTISTRY LA English DT Article AB Removable partial denture frameworks must fit accurately to function properly and not cause injury to remaining teeth or soft tissue. This article presents a logical method and rationale for seating a removable partial denture framework and a review of several disclosing media used in the try-in procedure. C1 USA,DENTAC,ADV PROSTHODONT RESIDENCY PROGRAM,FT SAM HOUSTON,TX 78234. RP WONG, MT (reprint author), USA,DENTAC,BUDGE DENT CLIN,518 WHEATON,FT SAM HOUSTON,TX 78234, USA. NR 6 TC 3 Z9 3 U1 0 U2 1 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0022-3913 J9 J PROSTHET DENT JI J. Prosthet. Dent. PD APR PY 1993 VL 69 IS 4 BP 363 EP 368 DI 10.1016/0022-3913(93)90181-M PG 6 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA KU698 UT WOS:A1993KU69800002 PM 8463963 ER PT J AU DEBOER, J AF DEBOER, J TI EDENTULOUS IMPLANTS - OVERDENTURE VERSUS FIXED SO JOURNAL OF PROSTHETIC DENTISTRY LA English DT Article ID OSSEOINTEGRATION AB Implant restorations for edentulous patients may be planned as either fixed restorations or removable overdentures. Several factors should be considered when deciding between these treatment alternatives. They may be grouped into factors related to (1) the entire patient, (2) both arches, (3) maxillary restorations, and (4) mandibular restorations. C1 USA,DENT ACT,FT BLISS,TX. NR 14 TC 36 Z9 38 U1 0 U2 7 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0022-3913 J9 J PROSTHET DENT JI J. Prosthet. Dent. PD APR PY 1993 VL 69 IS 4 BP 386 EP 390 DI 10.1016/0022-3913(93)90186-R PG 5 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA KU698 UT WOS:A1993KU69800007 PM 8463968 ER PT J AU MCCARTNEY, JW VERMILYEA, SG FOSDAL, T AF MCCARTNEY, JW VERMILYEA, SG FOSDAL, T TI MODIFICATION OF ANGULATED ABUTMENTS TO AVOID UNAESTHETIC DISPLAY OF METAL SO JOURNAL OF PROSTHETIC DENTISTRY LA English DT Article AB A procedure is described whereby the facial margin of angulated abutments are repositioned to avoid unesthetic display of metal in the anterior maxilla. The procedure is not difficult and can make a considerable difference in the patient's acceptance of the restoration. C1 WALTER REED ARMY MED CTR,DENT ACT,WASHINGTON,DC 20307. RP MCCARTNEY, JW (reprint author), VET AFFAIRS MED CTR,CENT DENT LAB 160L,50 IRVING ST NW,WASHINGTON,DC 20422, USA. NR 3 TC 5 Z9 5 U1 0 U2 2 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0022-3913 J9 J PROSTHET DENT JI J. Prosthet. Dent. PD APR PY 1993 VL 69 IS 4 BP 439 EP 441 DI 10.1016/0022-3913(93)90195-T PG 3 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA KU698 UT WOS:A1993KU69800016 PM 8463977 ER PT J AU NIELSEN, PE KILEY, KC ROSA, C AF NIELSEN, PE KILEY, KC ROSA, C TI RESIDENT TRAINING IN A MULTIDISCIPLINARY BREAST CLINIC SO JOURNAL OF REPRODUCTIVE MEDICINE LA English DT Article ID OBSTETRICS; GYNECOLOGY; DISEASE AB A multidisciplinary breast clinic was initiated at William Beaumont Army Medical Center involving resident and staff physicians from the Departments of Obstetrics and Gynecology, General Surgery, Radiology and Pathology. During the period August 1988 to May 1989, 2,186 mammograms (MOGs) were screened. For this report, 197 patients were evaluated. Of them, 187 patients had been referred to the breast clinic based on MOG findings. Pathologic specimen correlation with the mammograms was performed on a periodic basis. Thirty-four patients were biopsied based on either physical examination or MOG findings. Biopsy diagnoses included: normal tissue (1), fibrocystic disease (18), sclerosing adenosis (1), fibroadenoma (8), mastitis (1) and intraductal carcinoma (5). The Multidisciplinary Breast Clinic provided improved care through expedited patient management. Resident training was accomplished through refinement of examination and diagnostic skills, management of abnormal MOGs, needle aspiration of breast masses and improved communication between the different medical disciplines. C1 WILLIAM BEAUMONT ARMY MED CTR,DEPT OBSTET & GYNECOL,EL PASO,TX 79920. WOMACK ARMY COMMUNITY HOSP,CLIN SERV,FT BRAGG,NC. NR 3 TC 1 Z9 1 U1 1 U2 1 PU SCI PRINTERS & PUBL INC PI ST LOUIS PA P.O. DRAWER 12425 8342 OLIVE BLVD, ST LOUIS, MO 63132 SN 0024-7758 J9 J REPROD MED JI J. Reprod. Med. PD APR PY 1993 VL 38 IS 4 BP 278 EP 280 PG 3 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA KY532 UT WOS:A1993KY53200006 PM 8501734 ER PT J AU WALDEN, BE BUSACCO, DA MONTGOMERY, AA AF WALDEN, BE BUSACCO, DA MONTGOMERY, AA TI BENEFIT FROM VISUAL CUES IN AUDITORY-VISUAL SPEECH RECOGNITION BY MIDDLE-AGED AND ELDERLY PERSONS SO JOURNAL OF SPEECH AND HEARING RESEARCH LA English DT Article DE AUDITORY-VISUAL; SPEECHREADING; ELDERLY; SPEECH RECOGNITION ID NOISE; MASKING AB The benefit derived from visual cues in auditory-visual speech recognition and patterns of auditory and visual consonant confusions were compared for 20 middle-aged and 20 elderly men who were moderately to severely hearing impaired. Consonant-vowel nonsense syllables and CID sentences were presented to the subjects under auditory-only, visual-only, and auditory-visual test conditions. Benefit was defined as the difference between the scores in the auditory-only and auditory-visual conditions. The results revealed that the middle-aged and elderly subjects obtained similar benefit from visual cues in auditory-visual speech recognition. Further, patterns of consonant confusions were similar for the two groups. RP WALTER REED ARMY MED CTR, CTR ARMY AUDIOL & SPEECH, WASHINGTON, DC 20307 USA. NR 26 TC 26 Z9 27 U1 0 U2 6 PU AMER SPEECH-LANGUAGE-HEARING ASSOC PI ROCKVILLE PA 2200 RESEARCH BLVD, #271, ROCKVILLE, MD 20850-3289 USA SN 0022-4685 J9 J SPEECH HEAR RES JI J. Speech Hear. Res. PD APR PY 1993 VL 36 IS 2 BP 431 EP 436 PG 6 WC Language & Linguistics; Rehabilitation SC Linguistics; Rehabilitation GA KW998 UT WOS:A1993KW99800020 PM 8487533 ER PT J AU OSENBACH, RK HITCHON, PW MOUW, L YAMADA, T AF OSENBACH, RK HITCHON, PW MOUW, L YAMADA, T TI EFFECTS OF SPINAL-CORD ISCHEMIA ON EVOKED-POTENTIAL RECOVERY AND POSTISCHEMIC REGIONAL SPINAL-CORD BLOOD-FLOW SO JOURNAL OF SPINAL DISORDERS LA English DT Article DE SPINAL CORD ISCHEMIA; SPINAL CORD BLOOD FLOW; EVOKED POTENTIALS; RABBITS AB The effects of spinal cord ischemia on spinal cord blood flow (SCBF) and somatosensory (SSEP) and motor (MEP) evoked potentials were investigated in a rabbit model of reversible spinal cord ischemia. Spinal cord ischemia was produced by balloon occlusion of the infrarenal aorta for 30, 60, and 90 min. SCBF, SSEPs, and MEPs were measured before, during, and 1 h after aortic occlusion. Aortic occlusion produced absolute ischemia of the caudal cord followed by hyperemia upon reperfusion. SSEP's and MEP's were obliterated during ischemia but demonstrated gradual albeit incomplete recovery following reperfusion with amplitude recovery inversely proportional to the duration of ischemia. Later peaks were more severely affected by a given period of ischemia than were early waves. In general, SSEP's were more resistant to ischemia than were MEP's although the differences were not significant. RP OSENBACH, RK (reprint author), WALTER REED ARMY MED CTR,DIV NEUROSURG,5C23,WASHINGTON,DC 20307, USA. NR 0 TC 12 Z9 13 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0895-0385 J9 J SPINAL DISORD JI J. Spinal Disord. PD APR PY 1993 VL 6 IS 2 BP 146 EP 154 PG 9 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA KV389 UT WOS:A1993KV38900009 PM 8504227 ER PT J AU SAU, P GRAHAM, JH HELWIG, EB AF SAU, P GRAHAM, JH HELWIG, EB TI PIGMENTED SPINDLE CELL NEVUS - A CLINICOPATHOLOGICAL ANALYSIS OF 95 CASES SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Article ID LESION; TUMOR; REED AB Background: Pigmented spindle cell nevus (PSCN) is often interpreted as a Spitz nevus or misdiagnosed as malignant melanoma. Objective. The purpose of this study was to analyze the clinical and histologic features and to determine the biologic behavior of 95 cases of PSCN. Methods. We reviewed clinical data, follow-up information, and microscopic features of all 95 cases of PSCN. Results. PSCNs are dark brown to black, 3 to 6 mm in diameter, and occur most commonly on the extremities (7 5%) and back (1 6%) with a predilection for the legs. These lesions are more common in women in the third decade of life. Microscopically, PSCNs are characterized by uniform, spindle-shaped, pigmented melanocytes. Although some histologic features overlap with those in spindle and epithelioid cell nevus, PSCN is a separate entity. In addition, PSCN must be differentiated from malignant melanoma. Fifty-seven patients (60%) observed for an average of 6 years did not develop local recurrence or metastasis. Conclusion: PSCN is a distinctive, acquired, benign melanocytic lesion, that should not be confused with spindle and epithelioid cell nevus or malignant melanoma. Complete excision is recommended for treatment. C1 USAF,INST PATHOL,WASHINGTON,DC 20330. SCRIPPS CLIN & RES FDN,DEPT PATHOL,DIV DERMATOPATHOL,LA JOLLA,CA 92037. RP SAU, P (reprint author), WALTER REED ARMY MED CTR,DEPT DERMATOL & PATHOL,DERMATOL SERV,WASHINGTON,DC 20307, USA. NR 18 TC 38 Z9 38 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD APR PY 1993 VL 28 IS 4 BP 565 EP 571 PG 7 WC Dermatology SC Dermatology GA KU482 UT WOS:A1993KU48200004 PM 8463457 ER PT J AU KRAMER, FM STUNKARD, AJ MARSHALL, KA MCKINNEY, S LIEBSCHUTZ, J AF KRAMER, FM STUNKARD, AJ MARSHALL, KA MCKINNEY, S LIEBSCHUTZ, J TI BREAST-FEEDING REDUCES MATERNAL LOWER-BODY FAT SO JOURNAL OF THE AMERICAN DIETETIC ASSOCIATION LA English DT Article ID FOOD-RESTRICTED RATS; SKINFOLD THICKNESS; LIPOPROTEIN-LIPASE; LACTATING RATS; NO LACTATION; HUMAN-MILK; ONE CYCLE; WOMEN; POSTPARTUM; PREGNANCY AB The effect of breast-feeding on maternal anthropometric measures during the first 6 postpartum months was studied in 24 women. Mothers, who were seen in the hospital shortly after delivery and at monthly intervals thereafter, kept a record of their infant-feeding practices and provided three 24-hour dietary recalls per month. The women were placed in one of three groups according to their infant-feeding practices: breast-feeding exclusively, combination of breast- and formula-feeding, and formula-feeding only. Changes in anthropometric variables at 6 months postpartum were similar in the three groups, but mothers who breast-fed exclusively or partially had significantly larger reductions in hip circumference measurements (3.6% and 3.1%, respectively) and were less above their prepregnancy weights at 1 month postpartum (7.8% and 8.5% above prepregnancy weight, respectively) than mothers who fed formula exclusively (0.68% reduction in hip circumference and 13.7% above prepregnancy weight). Our findings indicate that a woman's choice of infant-feeding practice influences postpartum anthropometric changes, but these effects may be temporary. C1 UNIV PENN,DEPT PSYCHIAT,PHILADELPHIA,PA 19104. DREXEL UNIV,DEPT NUTR & FOOD SCI,PHILADELPHIA,PA 19104. RP KRAMER, FM (reprint author), USA,CTR RES DEV & ENGN,NATICK,MA 01760, USA. FU NIDDK NIH HHS [5-T32-DK07452]; NIMH NIH HHS [5-R01-MH31050] NR 42 TC 50 Z9 52 U1 2 U2 3 PU AMER DIETETIC ASSN PI CHICAGO PA 216 W JACKSON BLVD #800, CHICAGO, IL 60606-6995 SN 0002-8223 J9 J AM DIET ASSOC JI J. Am. Diet. Assoc. PD APR PY 1993 VL 93 IS 4 BP 429 EP 433 DI 10.1016/0002-8223(93)92289-A PG 5 WC Nutrition & Dietetics SC Nutrition & Dietetics GA KV996 UT WOS:A1993KV99600013 PM 8454811 ER PT J AU STRAWN, RC BARTH, TJ AF STRAWN, RC BARTH, TJ TI A FINITE-VOLUME EULER SOLVER FOR COMPUTING ROTARY-WING AERODYNAMICS ON UNSTRUCTURED MESHES SO JOURNAL OF THE AMERICAN HELICOPTER SOCIETY LA English DT Article AB An unstructured-grid solver for the unsteady Euler equations has been developed for predicting the aerodynamics of helicopter rotor blades. This now solver is a finite-volume scheme that computes flow quantities at the vertices of the mesh. Special treatments are used for the nux differencing and boundary conditions in order to compute rotary-wing flowfields, and these are detailed in the paper. The unstructured-grid solver permits adaptive-grid refinement in order to improve the resolution of flow features such as shocks, rotor wakes and acoustic waves. These capabilities are demonstrated in the paper. Example calculations are presented for two hovering rotors. In both cases, adaptive-grid refinement is used to resolve high gradients near the rotor surface and also to capture the vortical regions in the rotor wake. The computed results show good agreement with experimental results for surface airloads and wake geometry. C1 NASA,CFD BRANCH,MOFFETT FIELD,CA 94035. RP STRAWN, RC (reprint author), NASA,US ARMY AEROFLIGHTDYNAM,MOFFETT FIELD,CA 94035, USA. NR 12 TC 22 Z9 27 U1 0 U2 1 PU AMER HELICOPTER SOC INC PI ALEXANDRIA PA 217 N WASHINGTON ST, ALEXANDRIA, VA 22314 SN 0002-8711 J9 J AM HELICOPTER SOC JI J. Am. Helicopter Soc. PD APR PY 1993 VL 38 IS 2 BP 61 EP 67 PG 7 WC Engineering, Aerospace SC Engineering GA LC580 UT WOS:A1993LC58000007 ER PT J AU FAMINI, GR MARQUEZ, BC WILSON, LY AF FAMINI, GR MARQUEZ, BC WILSON, LY TI USING THEORETICAL DESCRIPTORS IN QUANTITATIVE STRUCTURE-ACTIVITY-RELATIONSHIPS - GAS-PHASE ACIDITY SO JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2 LA English DT Article ID SOLVATION ENERGY RELATIONSHIPS; SINGLE IONS; SOLVENTS; MOLECULES; PARAMETERS; WATER; RULES AB The application of computational techniques to biology, chemistry and physics is growing rapidly. Quantitative structure-activity relationships (QSAR) have been used widely to relate biological activities as well as physicochemical properties to molecular structure features. A difficulty in this approach has been nonuniformity of parameter sets resulting in the inability to examine contributions across properties and data sets. Linear solvation energy relationships (LSER) developed by Kamlet and Taft successfully utilize a single set of parameters to correlate a wide range of biological, chemical and physical properties. We have replaced the empirical LSER solvatochromic parameters with theoretically determined parameters to permit greater ease in a priori property prediction. These TLSER descriptors have given good correlations and interpretations for some biological activities and physicochemical properties. This paper discusses the application of these descriptors to the gas phase acidity of some carboxylic acids, alcohols, silanols, anilines, hydrocarbons, and oximes. Good correlations and physical interpretations result. C1 LA SIERRA UNIV,DEPT CHEM,RIVERSIDE,CA 92515. USA,EDGEWOOD RES DEV & ENGN CTR,ABERDEEN PROVING GROUND,MD 21010. NR 47 TC 19 Z9 19 U1 1 U2 4 PU ROYAL SOC CHEMISTRY PI CAMBRIDGE PA THOMAS GRAHAM HOUSE, SCIENCE PARK MILTON ROAD, CAMBRIDGE, CAMBS, ENGLAND CB4 4WF SN 0300-9580 J9 J CHEM SOC PERK T 2 JI J. Chem. Soc.-Perkin Trans. 2 PD APR PY 1993 IS 4 BP 773 EP 782 DI 10.1039/p29930000773 PG 10 WC Chemistry, Organic; Chemistry, Physical SC Chemistry GA KX924 UT WOS:A1993KX92400031 ER PT J AU MILLER, WB RICKLIN, JC ANDREWS, LC AF MILLER, WB RICKLIN, JC ANDREWS, LC TI LOG-AMPLITUDE VARIANCE AND WAVE STRUCTURE-FUNCTION - A NEW PERSPECTIVE FOR GAUSSIAN BEAMS SO JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION LA English DT Article ID MUTUAL COHERENCE FUNCTION; TURBULENT MEDIA; PROPAGATION AB Two naturally linked pairs of nondimensional parameters are identified such that either pair, together with wavelength and path length, completely specifies the diffractive propagation environment for a lowest-order paraxial Gaussian beam. Both parameter pairs are intuitive, and within the context of locally homogeneous and isotropic turbulence they reflect the long-recognized importance of the Fresnel zone size in the behavior of Rytov propagation statistics. These parameter pairs, called, respectively, the transmitter and receiver parameters, also provide a change in perspective in the analysis of optical turbulence effects on Gaussian beams by unifying a number of behavioral traits previously observed or predicted, and they create an environment in which the determination of limiting interrelationships between beam forms is especially simple. The fundamental nature of the parameter pairs becomes apparent in the derived analytical expressions for the log-amplitude variance and the wave structure function. These expressions verify general optical turbulence-related characteristics predicted for Gaussian beams, provide additional insights into beam-wave behavior, and are convenient tools for beam-wave analysis. C1 UNIV CENT FLORIDA,DEPT ELECT ENGN,ORLANDO,FL 32816. UNIV CENT FLORIDA,DEPT MATH,ORLANDO,FL 32816. RP MILLER, WB (reprint author), USA,RES LAB,BATTLEFIELD ENVIRONM DIRECTORATE,WHITE SANDS MISSILE RANGE,NM 88002, USA. NR 23 TC 43 Z9 43 U1 0 U2 2 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0740-3232 J9 J OPT SOC AM A JI J. Opt. Soc. Am. A-Opt. Image Sci. Vis. PD APR PY 1993 VL 10 IS 4 BP 661 EP 672 DI 10.1364/JOSAA.10.000661 PG 12 WC Optics SC Optics GA KU219 UT WOS:A1993KU21900012 ER PT J AU KOLKA, MA STEPHENSON, LA AF KOLKA, MA STEPHENSON, LA TI ANTICHOLINESTERASE ADMINISTRATION DURING ACUTE ALTITUDE EXPOSURE SO JOURNAL OF THERMAL BIOLOGY LA English DT Article DE ANTICHOLINESTERASE; EXERCISE; HYPOBARIA; SWEATING RATE; BODY TEMPERATURE; MAN ID SKIN BLOOD-FLOW; EXERCISE AB 1. Red blood cell cholinesterase activity was decreased an average of -31 +/- 9%, -41 +/- 8%, -35 +/- 7% and -41 +/- 13% after 2, 26, 50 and 74 h of pyridostigmine treatment (30 mg, t.i.d.). 2. Pyridostigmine decreased resting heart rate at sea level (SL) by 7 +/- 10 b.min-1 after 74 h (P < 0.05). Resting esophageal temperature (T(es)) was -0.28 +/- 0.16-degrees-C at 10,000 ft and -0.10 +/- 0.22-degrees-C after 74 h (SL) compared to SL control; and was +0.20 +/- 0.10-degrees-C after 2 h and +0.20 +/- 0.13-degrees-C after 26 h at 10,000 ft compared to altitude control (P < 0.05). 3. The thermosensitivity of forearm sweating to increasing T(es) was 26 +/- 3% lower at altitude compared to sea level (P < 0.05). This depression in thermosensitivity was not observed at altitude with pyridostigmine. The T(es) threshold for onset of forearm sweating was increased 0.2-degrees-C after 26 h of pyridostigmine compared to control altitude experiments (P < 0.05). 4. The depressing effect of acute hypobaric hypoxia on thermosensitivity of sweating was confirmed by this study. Pyridostigmine administration did not affect skin blood flow responses during acute altitude exposure. RP KOLKA, MA (reprint author), USA,ENVIRONM MED RES INST,DIV THERMAL PHYSIOL & MED,NATICK,MA 01760, USA. NR 19 TC 0 Z9 0 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0306-4565 J9 J THERM BIOL JI J. Therm. Biol. PD APR PY 1993 VL 18 IS 2 BP 103 EP 112 DI 10.1016/0306-4565(93)90022-L PG 10 WC Biology; Zoology SC Life Sciences & Biomedicine - Other Topics; Zoology GA LE152 UT WOS:A1993LE15200005 ER PT J AU LOGAN, TM LINTHICUM, KJ MOULTON, JR KSIAZEK, TG AF LOGAN, TM LINTHICUM, KJ MOULTON, JR KSIAZEK, TG TI ANTIGEN-CAPTURE ENZYME-LINKED-IMMUNOSORBENT-ASSAY FOR DETECTION AND QUANTIFICATION OF CRIMEAN-CONGO HEMORRHAGIC-FEVER VIRUS IN THE TICK, HYALOMMA-TRUNCATUM SO JOURNAL OF VIROLOGICAL METHODS LA English DT Article DE DETECTION; CRIMEAN-CONGO HEMORRHAGIC FEVER VIRUS; ELISA; PLAQUE-ASSAY; TICK ID TRANSMISSION AB A viral antigen-capture ELISA was compared to a viral plaque-assay on human cell monolayers for detection and quantification of Crimean-Congo hemorrhagic fever virus in triturated experimentally infected Hyalomma truncatum ticks. In suspensions of ticks exposed as larvae to viremic mice, the ELISA detected 13% positive as compared to 3% (n = 721) positive by plaque-assay. Adult ticks inoculated with virus and sampled up to 102 days later were 84% positive by ELISA compared to 36% (n = 273) positive by plaque-assay. The two tests detected similar proportions of positive ticks in the two weeks immediately after viral inoculation; however, the ELISA was positive in 100% of inoculated adult ticks from 18-102 days post-inoculation while the plaque-assay was positive in 33% (n = 135) of the same specimens. CCHF viral antigen was detected in 10% (n = 101) of first-generation progeny tested as unfed larva pools by ELISA, yet no virus was detected by plaque-assay, indicating that either non-infective viral fragments or very low levels of live virus were detected by ELISA in these tick progeny. As detected by plaque assay, virus inoculated unfed adult ticks were virtually all infected by day 8 post-inoculation; by day 21 post-inoculation only 33% were detected as positive. A cohort of these ticks were allowed to blood feed from day 21-31 post-inoculation. When assayed after feeding all female ticks and nearly 50% of male ticks were detected as virus-positive. This indicates that the virus likely persisted in the unfed ticks below the level of detectability of the plaque-assay and increased in the blood fed ticks up to a detectable level. The ELISA however, detected 100% of ticks as virus-positive from day 14 post-inoculation throughout the remainder of the study, regardless of feeding status (day 102 post-inoculation). These results indicate that antigen-detection ELISA is more sensitive in detecting CCHF virus in ticks than plaque-assay. Since an infected tick remains antigen-positive by ELISA for possibly the remainder of its life, this assay will be a major improvement in field surveys and vector competency studies of ticks for CCHF virus. RP LOGAN, TM (reprint author), USA,MRIID,DIV DIS ASSESSMENT,DEPT EPIDEMIOL,FT DETRICK,MD 21702, USA. NR 10 TC 21 Z9 22 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-0934 J9 J VIROL METHODS JI J. Virol. Methods PD APR PY 1993 VL 42 IS 1 BP 33 EP 44 DI 10.1016/0166-0934(93)90174-P PG 12 WC Biochemical Research Methods; Biotechnology & Applied Microbiology; Virology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Virology GA KV469 UT WOS:A1993KV46900004 PM 8320308 ER PT J AU LUNDSTROM, JO TURELL, MJ NIKLASSON, B AF LUNDSTROM, JO TURELL, MJ NIKLASSON, B TI VIREMIA IN 3 ORDERS OF BIRDS (ANSERIFORMES, GALLIFORMES AND PASSERIFORMES) INOCULATED WITH OCKELBO VIRUS SO JOURNAL OF WILDLIFE DISEASES LA English DT Article DE ALPHAVIRUS; OCKELBO VIRUS; EXPERIMENTAL VIREMIA; BIRD; PASSERIFORMES; AMPLIFICATION HOST; INCIDENTAL HOST ID ENVIRONMENTAL-TEMPERATURE; UNIVITTATUS THEOBALD; VECTOR COMPETENCE; SINDBIS VIRUSES; CULEX-PIPIENS; WEST NILE; SWEDEN; DISEASE; CULICIDAE; DIPTERA AB One-hundred six birds of 14 species were inoculated with approximately 10(2.7) plaque-forming units of Ockelbo virus and bled daily for 5 days to determine viremia levels. Virus was detected in birds of all 14 species tested (four Anseriformes, one Galliformes and nine Passeriformes). The onset of viremia occurred earlier and viral titers were higher in very young anseriforms and galliforms than in older birds. Adult passeriforms had Ockelbo viremias of higher titer and longer duration than did adult anseriforms. Viremia titers in adult birds of all three orders tested were sufficient to induce high transmission rates in enzootic mosquito vectors, and viremias in passeriforms could induce high transmission rates in bridging vectors as well. Passeriforms of the genera Turdus and Fringilla could serve as amplification hosts for Ockelbo virus based on the presently demonstrated viremia of high titer and long duration in these birds, and the previously demonstrated high prevalence of Ockelbo virus neutralizing antibodies in free-ranging individuals and great population size compared to birds of other taxa. Bird species of all three orders tested, however, could function as incidental hosts of the virus. C1 USA,MED RES INST INFECT DIS,DEPT ARBOVIRAL ENTOMOL,DIV VIROL,FREDERICK,MD 21702. SWEDISH DEF RES ESTAB,S-90182 UMEA,SWEDEN. KAROLINSKA INST,NATL BACTERIOL LAB,DEPT VIROL,S-10521 STOCKHOLM,SWEDEN. RP LUNDSTROM, JO (reprint author), NATL BACTERIOL LAB,DEPT VIROL,S-10521 STOCKHOLM,SWEDEN. NR 36 TC 21 Z9 21 U1 0 U2 0 PU WILDLIFE DISEASE ASSN, INC PI LAWRENCE PA 810 EAST 10TH ST, LAWRENCE, KS 66044-8897 SN 0090-3558 J9 J WILDLIFE DIS JI J. Wildl. Dis. PD APR PY 1993 VL 29 IS 2 BP 189 EP 195 PG 7 WC Veterinary Sciences SC Veterinary Sciences GA KY278 UT WOS:A1993KY27800001 PM 8387608 ER PT J AU MOUL, JW AF MOUL, JW TI KIMBROUGH,JAMES,CLAUDE - THE FATHER OF MODERN UNITED-STATES-ARMY UROLOGY SO MILITARY MEDICINE LA English DT Item About an Individual RP MOUL, JW (reprint author), WALTER REED ARMY MED CTR,UROL SERV,WASHINGTON,DC 20307, USA. NR 0 TC 1 Z9 1 U1 0 U2 1 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD APR PY 1993 VL 158 IS 4 BP 213 EP 222 PG 10 WC Medicine, General & Internal SC General & Internal Medicine GA KX614 UT WOS:A1993KX61400012 PM 8479626 ER PT J AU VANDRE, RH KLEBERS, J TESCHE, FM BLANCHARD, JP AF VANDRE, RH KLEBERS, J TESCHE, FM BLANCHARD, JP TI ELECTROMAGNETIC PULSE (EMP) .1. EFFECTS ON FIELD MEDICAL EQUIPMENT SO MILITARY MEDICINE LA English DT Article AB The electromagnetic pulse (EMP) from a high-altitude nuclear detonation has the potential to cover an area as large as the continental United States with damaging levels of EMP radiation. In this study, two of seven items of medical equipment were damaged by an EMP simulator. Computer circuit analysis of 17 different items showed that 11 of the 17 items would be damaged by current surges on the power cords, while two would be damaged by current surges on external leads. This research showed that a field commander can expect approximately 65% of his electronic medical equipment to be damaged by a single nuclear detonation as far as 2,200 km away. RP VANDRE, RH (reprint author), WALTER REED ARMY MED CTR,INST DENT RES,WASHINGTON,DC 20307, USA. NR 0 TC 1 Z9 2 U1 0 U2 1 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD APR PY 1993 VL 158 IS 4 BP 233 EP 236 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA KX614 UT WOS:A1993KX61400015 PM 8479629 ER PT J AU MANGELSDORFF, AD MOSES, GR AF MANGELSDORFF, AD MOSES, GR TI A SURVEY OF ARMY-MEDICAL-DEPARTMENT RESERVE PERSONNEL MOBILIZED IN SUPPORT OF OPERATION DESERT STORM SO MILITARY MEDICINE LA English DT Article AB Surveys from 3,930 Army medical reservists mobilized in support of the Health Services Command mission during Operation Desert Shield/Storm were collected as units were demobilized from April to June, 1991. A survey questionnaire addressed questions related to factors associated with mobilization and intentions to remain in or leave reserve service after demobilization. Results were grouped according to rank, years of service, occupational specialty, and reserve category. Survey items used 6-point Likert scales to rate 38 items. Stepwise multiple regression models were developed to predict criterion items. RP MANGELSDORFF, AD (reprint author), USA,HLTH SERV COMMAND,HLTH CARE STUDIES & CLIN INVEST ACTIV,FT SAM HOUSTON,TX 78234, USA. NR 0 TC 4 Z9 4 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD APR PY 1993 VL 158 IS 4 BP 254 EP 258 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA KX614 UT WOS:A1993KX61400019 PM 8479633 ER PT J AU SOLDANO, SL PLACE, LB EDWARDS, FH COHEN, AJ AF SOLDANO, SL PLACE, LB EDWARDS, FH COHEN, AJ TI POSTEXTUBATION NONCARDIOGENIC PULMONARY-EDEMA SO MILITARY MEDICINE LA English DT Article AB Non-cardiogenic pulmonary edema (NCPE) is a rare entity manifested by pulmonary edema with normal pulmonary arterial pressures. NCPE has been described in children and recently reported in adults. Onset is rapid and late recognition or inappropriate treatment may lead to a fatal outcome. Most adult cases have been attributed to laryngospasm and generation of a large negative intrathoracic pressure causing transcapillary filtration. The majority of reported adult cases were at risk for Upper Airway Obstruction (UAO). This report describes three young, active duty men who developed this entity following routine uncomplicated surgical procedures. Intubations were uncomplicated and fluid management appropriate. No patient had risk factors for UAO. Early extubation with respiratory attempts against a closed glottis may be etiology for this complication. RP SOLDANO, SL (reprint author), WALTER REED ARMY MED CTR,DEPT SURG,WASHINGTON,DC 20307, USA. NR 0 TC 7 Z9 7 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD APR PY 1993 VL 158 IS 4 BP 278 EP 280 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA KX614 UT WOS:A1993KX61400026 PM 8479640 ER PT J AU LINDLER, LE TALL, BD AF LINDLER, LE TALL, BD TI YERSINIA-PESTIS PH-6 ANTIGEN FORMS FIMBRIAE AND IS INDUCED BY INTRACELLULAR ASSOCIATION WITH MACROPHAGES SO MOLECULAR MICROBIOLOGY LA English DT Article ID UROPATHOGENIC ESCHERICHIA-COLI; MOUSE PERITONEAL-MACROPHAGES; CHAPERONE PROTEIN-PAPD; NUCLEOTIDE-SEQUENCE; VIRULENCE DETERMINANTS; K99 FIMBRIAE; PLASMID; PILUS; BIOSYNTHESIS; BINDING AB Ability to express pH 6 antigen (Ag) is necessary for full virulence of Yersinia pestis; however, the function of the Ag in pathogenesis remains unclear. We determined the nucleotide sequence of a 4232 bp region of Y. pestis DNA which encoded the pH 6 Ag structural gene (psaA) and accessory loci necessary for Ag synthesis. Protein sequences encoded by the Y. pestis DNA were similar to accessory proteins which function in the biosynthesis of Escherichia coli fimbriae Pap, K88, K99 and CS3 as well as the molecular chaperone for the Y. pestis capsule protein. Electron microscopy and immunogold labelling studies revealed that pH 6 Ag expressing E. coli or Yersinia produced flexible 'fibrillar' organelles composed of individual linear strands, multiple strand bundles or wiry aggregates of PsaA. Y. pestis associated with the murine macrophage-like cell line, RAW264.7, expressed pH 6 Ag in an intracellular acidification-dependent manner. Together with an earlier study showing that a Y. pestis psaA mutant was reduced in virulence, these results demonstrate that the expression of fimbriae which are induced in host macrophages is involved in plague pathogenesis. C1 US FDA,DIV MICROBIOL,WASHINGTON,DC 20204. RP LINDLER, LE (reprint author), WALTER REED ARMY INST RES,DEPT IMMUNOL,DIV COMMUNICABLE DIS & IMMUNOL,WASHINGTON,DC 20307, USA. OI Tall, Ben/0000-0003-0399-3629 NR 55 TC 107 Z9 113 U1 1 U2 2 PU BLACKWELL SCIENCE LTD PI OXFORD PA OSNEY MEAD, OXFORD, OXON, ENGLAND OX2 0EL SN 0950-382X J9 MOL MICROBIOL JI Mol. Microbiol. PD APR PY 1993 VL 8 IS 2 BP 311 EP 324 DI 10.1111/j.1365-2958.1993.tb01575.x PG 14 WC Biochemistry & Molecular Biology; Microbiology SC Biochemistry & Molecular Biology; Microbiology GA KY689 UT WOS:A1993KY68900012 PM 8100346 ER PT J AU MAY, EF LING, GSF GEYER, CA JABBARI, B AF MAY, EF LING, GSF GEYER, CA JABBARI, B TI CONTRAST AGENT OVERDOSE CAUSING BRAIN RETENTION OF CONTRAST, SEIZURES, AND PARKINSONISM SO NEUROLOGY LA English DT Note AB A patient received an overdose of intravascular contrast medium and experienced protracted seizures associated with radiographic evidence of prolonged retention of the contrast agent in the cerebral cortex, basal ganglia, and thalami. This is only the second report and the first survivor of a similar neurologic syndrome occurring in a patient after contrast agent overdose. After the seizures resolved, there was a transient period of parkinsonism probably due to the toxic effect of contrast on the basal ganglia. C1 WALTER REED ARMY INST RES,DEPT NEUROL,WASHINGTON,DC 20307. WALTER REED ARMY INST RES,DEPT RADIOL,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,DEPT NEUROL,BETHESDA,MD 20814. UNIFORMED SERV UNIV HLTH SCI,DEPT RADIOL,BETHESDA,MD 20814. RP MAY, EF (reprint author), MADIGAN ARMY MED CTR,NEUROL SERV,TACOMA,WA 98431, USA. NR 10 TC 15 Z9 15 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0028-3878 J9 NEUROLOGY JI Neurology PD APR PY 1993 VL 43 IS 4 BP 836 EP 838 PG 3 WC Clinical Neurology SC Neurosciences & Neurology GA KX812 UT WOS:A1993KX81200039 PM 8469350 ER PT J AU GUPTA, N PHAM, J SIMONIS, GJ STEAD, MR AF GUPTA, N PHAM, J SIMONIS, GJ STEAD, MR TI OPERATION OF AN OPTOELECTRONIC ALGAAS/GAAS WAVE-GUIDE NEURON SO OPTICS LETTERS LA English DT Article ID MULTIPLE AB A novel monolithic AlGaAs/GaAs waveguide neuron is proposed and implemented with a Wannier-Stark superlattice in the core. Dynamic weighting, summing, and thresholding of signals is done by chip-level integration of modulators and a saturable absorber on a rib waveguide power combiner. At 780 nm (below the band gap) the range for synaptic weights is between 1 and -25 dB/mm for reverse bias below 7 V, and the modulation depth is 25 dB for the thresholding element. For a two-to-one neuron, the output-input range ratio is 25 dB. RP GUPTA, N (reprint author), USA,RES LAB,ADELPHI,MD 20783, USA. RI Gupta, Neelam/B-8702-2013 NR 11 TC 0 Z9 0 U1 0 U2 4 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0146-9592 J9 OPT LETT JI Opt. Lett. PD APR 1 PY 1993 VL 18 IS 7 BP 519 EP 521 DI 10.1364/OL.18.000519 PG 3 WC Optics SC Optics GA KU378 UT WOS:A1993KU37800017 PM 19802187 ER PT J AU CIESLAK, TJ MULLETT, CT PUNTEL, RA LATIMER, JS AF CIESLAK, TJ MULLETT, CT PUNTEL, RA LATIMER, JS TI MENETRIERS DISEASE ASSOCIATED WITH CYTOMEGALOVIRUS-INFECTION IN CHILDREN - REPORT OF 2 CASES AND REVIEW OF THE LITERATURE SO PEDIATRIC INFECTIOUS DISEASE JOURNAL LA English DT Article DE MENETRIERS DISEASE; CYTOMEGALOVIRUS ID HYPERTROPHIC GASTROPATHY; CHILDHOOD; GASTRITIS C1 WALTER REED ARMY MED CTR,DEPT PEDIAT,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,DEPT PEDIAT,BETHESDA,MD 20814. NR 27 TC 29 Z9 30 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0891-3668 J9 PEDIATR INFECT DIS J JI Pediatr. Infect. Dis. J. PD APR PY 1993 VL 12 IS 4 BP 340 EP 343 DI 10.1097/00006454-199304000-00014 PG 4 WC Immunology; Infectious Diseases; Pediatrics SC Immunology; Infectious Diseases; Pediatrics GA KW848 UT WOS:A1993KW84800014 PM 8387180 ER PT J AU EASA, D UYEHARA, CFT STEVENS, EL FINN, KC BALARAMAN, V SIM, H AF EASA, D UYEHARA, CFT STEVENS, EL FINN, KC BALARAMAN, V SIM, H TI PANCURONIUM DOES NOT ALTER THE HEMODYNAMIC STATUS OF PIGLETS AFTER NORMOXIA OR HYPOXIA SO PEDIATRIC RESEARCH LA English DT Article ID VENTILATED INFANTS; BLOOD-PRESSURE; PULMONARY-HYPERTENSION; NEWBORN-INFANTS; HEART-RATE; BROMIDE; CATECHOLAMINE; MECHANICS; PARALYSIS; SEPSIS AB Pancuronium is a neuromuscular blocking agent commonly used to eliminate agitation in sick newborn infants requiring mechanical ventilation. Experimental data supporting this method of intervention are controversial, and hemodynamic studies in newborn infants report conflicting results. This study was designed to determine the hemodynamic effects of pancuronium administered under conditions of normoxia, hypoxia, and preexposure to hypoxia in neonatal piglets with normal lungs. After baseline hemodynamic and blood gas measurements were obtained, pancuronium was administered in two i.v. bolus injections of 0.1 mg/kg. Tidal volume and minute ventilation were maintained constant during the experimental procedure by adjusting ventilator settings. Twenty min after pancuronium, no changes from baseline values were found in arterial blood gases, heart rate, cardiac output, mean arterial pressure, systemic vascular resistance, pulmonary artery pressure, pulmonary vascular resistance, central venous pressure, or pulmonary capillary wedge pressure in any of the three conditions studied. In conclusion, pancuronium administered during normoxia, hypoxia, or after preexposure to hypoxia while controlled ventilation is maintained does not alter systemic or pulmonary hemodynamic status of the newborn piglet. C1 TRIPLER ARMY MED CTR,DEPT CLIN INVEST,HONOLULU,HI 96859. TRIPLER ARMY MED CTR,DEPT PEDIAT,HONOLULU,HI 96859. RP EASA, D (reprint author), JOHN A BURNS SCH MED,KAPIOLANI MED CTR WOMEN & CHILDREN,DEPT PEDIAT,1319 PUNAHOU ST,HONOLULU,HI 96826, USA. NR 37 TC 10 Z9 10 U1 0 U2 1 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1993 VL 33 IS 4 BP 365 EP 372 PN 1 PG 8 WC Pediatrics SC Pediatrics GA KV791 UT WOS:A1993KV79100011 PM 8479817 ER PT J AU RYSKA, TA AF RYSKA, TA TI THE RELATIONSHIP BETWEEN TRAIT AND PRECOMPETITIVE STATE ANXIETY AMONG HIGH-SCHOOL ATHLETES SO PERCEPTUAL AND MOTOR SKILLS LA English DT Article ID TEMPORAL CHANGES; PERFORMANCE; COMPETITION AB A sample of 270 tennis players representing 56 high school programs were assessed on competitive trait and state anxiety during the active season. A series of multivariate analyses of variance indicated that highly trait-anxious athletes reported greater cognitive A-state, greater somatic A-state, and lower state self-confidence than low trait-anxious athletes. RP RYSKA, TA (reprint author), US MIL ACAD,DEPT PHYS EDUC,W POINT,NY 10996, USA. NR 11 TC 1 Z9 1 U1 2 U2 2 PU PERCEPTUAL MOTOR SKILLS PI MISSOULA PA PO BOX 9229, MISSOULA, MT 59807 SN 0031-5125 J9 PERCEPT MOTOR SKILL JI Percept. Mot. Skills PD APR PY 1993 VL 76 IS 2 BP 413 EP 414 PG 2 WC Psychology, Experimental SC Psychology GA KY257 UT WOS:A1993KY25700014 PM 8483648 ER PT J AU ANDERSON, SM KANT, GJ DESOUZA, EB AF ANDERSON, SM KANT, GJ DESOUZA, EB TI EFFECTS OF CHRONIC STRESS ON ANTERIOR-PITUITARY AND BRAIN CORTICOTROPIN-RELEASING FACTOR RECEPTORS SO PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR LA English DT Article DE STRESS; CORTICOTROPIN-RELEASING FACTOR; CRF RECEPTORS; NEUROHUMOR RECEPTORS; ANTERIOR PITUITARY GLAND ID FACTOR-LIKE IMMUNOREACTIVITY; RAT-BRAIN; FACTOR CRF; DIFFERENTIAL REGULATION; HORMONE CRH; ALZHEIMERS-DISEASE; DEPRESSED-PATIENTS; BETA-ENDORPHIN; CYCLIC-AMP; CORTICOSTERONE AB [I-125]Corticotropin-releasing factor binding was measured in membrane homogenates prepared from the anterior pituitary, frontal cortex, motor cortex, somatosensory cortex, mesolimbic area (olfactory tubercle and nucleus accumbens), caudate putamen, hypothalamus, midbrain, and cerebellum from control and chronically stressed rats. The stressor consisted of 3 or 14 days of around-the-clock intermittent foot-shock (approximately one trial per 5-min frequency) that could be avoided or escaped on 90% of the trials presented by pulling a ceiling chain. Plasma corticosterone levels were almost doubled in stressed rats following 3 days of chronic stress and remained significantly elevated in rats stressed for 14 days as compared to controls. Plasma corticotropin levels were similar in controls and stressed animals in both the 3- and 14-day experiments. [I-125]Corticotropin-releasing factor binding was decreased in anterior pituitary and frontal cortex following 3 days of chronic stress; binding affinity of anterior pituitary membranes was not different between control and stressed animals. [I-125]Corticotropin-releasing factor binding was similar in control and 3-day-stressed animals in the other brain areas examined. After 14 days of chronic stress, hypothalamic [I-125]corticotropin-releasing factor binding was decreased in stressed rats as compared to control animals but no other differences were seen. The decrease in the apparent number of anterior pituitary corticotropin-releasing factor receptors following 3 days of stress may be due, in part, to increased plasma corticosterone levels and/or increased corticotropin-releasing factor secretion during that time. The downregulation of frontal cortex and hypothalamic corticotropin-releasing factor receptors, however, is more likely to be primarily in response to sustained stress-induced corticotropin-releasing factor release at those sites. C1 NIDA,ADDICT RES CTR,NEUROSCI BRANCH,BALTIMORE,MD 21224. JOHNS HOPKINS UNIV,SCH MED,DEPT PATHOL,BALTIMORE,MD 21205. RP ANDERSON, SM (reprint author), WALTER REED ARMY INST RES,DEPT MED NEUROSCI,WASHINGTON,DC 20307, USA. NR 51 TC 59 Z9 59 U1 0 U2 3 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0091-3057 J9 PHARMACOL BIOCHEM BE JI Pharmacol. Biochem. Behav. PD APR PY 1993 VL 44 IS 4 BP 755 EP 761 DI 10.1016/0091-3057(93)90002-B PG 7 WC Behavioral Sciences; Neurosciences; Pharmacology & Pharmacy SC Behavioral Sciences; Neurosciences & Neurology; Pharmacology & Pharmacy GA KU641 UT WOS:A1993KU64100002 PM 8385781 ER PT J AU PASTEL, RH ECHEVARRIA, E COX, B BLACKBURN, TP TORTELLA, FC AF PASTEL, RH ECHEVARRIA, E COX, B BLACKBURN, TP TORTELLA, FC TI EFFECTS OF CHRONIC TREATMENT WITH 2 SELECTIVE 5-HT2 ANTAGONISTS ON SLEEP IN THE RAT SO PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR LA English DT Article DE SEROTONIN-2 ANTAGONISTS; ICI-170,809; ICI-169,369; SLEEP; REM; RATS ID 5-HYDROXYTRYPTAMINE RECEPTOR SUBTYPES; SLOW-WAVE SLEEP; SEROTONERGIC AGENTS; REM-SLEEP; RITANSERIN; ICI-169,369; DEPRESSION; AMITRIPTYLINE; ZIMELIDINE; ACTIVATOR AB The effect of chronic administration of 2(2-dimethylaminoethylthio)-3-phenylquinoline (ICI-169,369) and 2(2-dimethylamino-2-methylpropylthio)-3-phenylquinoline (ICI-170,809), two selective 5-HT2 antagonists, on sleep was studied in rats. As previously shown, the acute effect of ICI-170,809 was to increase latency to rapid eye movement sleep (REMS), decrease the number of REM periods (REMPs), suppress the cumulative amount of REMS over 12 h, and increase the duration of REMPs in the first 6 h, while having no effect on non-REM sleep (NREMS). Administration of ICI-169,369 had similar effects except no change was seen in the duration of REMPs and cumulative REMS was suppressed for 24 h. When given 2x daily for 5 days, tolerance to the REMS suppressant effects developed in both drugs. After discontinuation of treatment, a REMS rebound occurred after ICI-170,809, but not ICI-169,369. No significant effect on NREMS was seen after administration of ICI-170,809, whereas ICI-169,369 lowered 24-h cumulative NREMS on the fifth day of administration. C1 ICI PLC,DIV PHARMACEUT,BIOSCI 2,MACCLESFIELD SK10 4TG,CHESHIRE,ENGLAND. SMITHKLINE BEECHAM PHARMACEUT,HARLOW CM19 5AD,ESSEX,ENGLAND. RP PASTEL, RH (reprint author), WALTER REED ARMY INST RES,DEPT MED NEUROSCI,DIV NEUROPSYCHIAT,WASHINGTON,DC 20307, USA. NR 41 TC 2 Z9 3 U1 1 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0091-3057 J9 PHARMACOL BIOCHEM BE JI Pharmacol. Biochem. Behav. PD APR PY 1993 VL 44 IS 4 BP 797 EP 804 DI 10.1016/0091-3057(93)90008-H PG 8 WC Behavioral Sciences; Neurosciences; Pharmacology & Pharmacy SC Behavioral Sciences; Neurosciences & Neurology; Pharmacology & Pharmacy GA KU641 UT WOS:A1993KU64100008 PM 8469691 ER PT J AU DEAK, J MCELFRESH, M CLEM, JR HAO, ZD KONCZYKOWSKI, M MUENCHAUSEN, R FOLTYN, S DYE, R AF DEAK, J MCELFRESH, M CLEM, JR HAO, ZD KONCZYKOWSKI, M MUENCHAUSEN, R FOLTYN, S DYE, R TI IDENTIFYING THE LOSS OF CRITICAL CURRENT-DENSITY IN YBA2CU3O7 THIN-FILMS SO PHYSICAL REVIEW B LA English DT Note ID SUPERCONDUCTORS; DEPOSITION; CREEP; PHASE AB The magnetic and magnetotransport behavior of a YBa2Cu3O7 thin-film sample was studied by a variety of methods that have been used previously to determine the irreversibility line (IRL). From transport measurements it is possible to identify at least two regions separated by a boundary identified as a vortex-glass transition, with the region below the boundary having zero linear resistance and that above having a low-current linear resistivity which seems to be associated with thermally activated flux motion. Evidence for flux pinning above the glass transition suggests that there is a loss of critical current density (J(c)) rather than an onset of reversible magnetic behavior at the glass transition. The complications of using first-harmonic ac susceptibility (chi(ac)) to define the IRL are discussed. In addition, the third-harmonic chi(ac) is shown to measure the same property that the first-harmonic chi(ac) measures: ac magnetic-field penetration rather than the loss of J(c). Results and a theoretical model showing that there are significant differences between field-cooled dc magnetization measurements when the data are collected on warming versus collecting data on cooling are presented. C1 IOWA STATE UNIV SCI & TECHNOL,AMES LAB,AMES,IA 50011. IOWA STATE UNIV SCI & TECHNOL,DEPT PHYS & ASTRON,AMES,IA 50011. ECOLE POLYTECH,CEREM,SOLIDES IRRADIES LAB,F-91128 PALAISEAU,FRANCE. LOS ALAMOS NATL LAB,ERDC,LOS ALAMOS,NM 87545. RP DEAK, J (reprint author), PURDUE UNIV,DEPT PHYS,W LAFAYETTE,IN 47907, USA. NR 19 TC 35 Z9 35 U1 0 U2 0 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0163-1829 J9 PHYS REV B JI Phys. Rev. B PD APR 1 PY 1993 VL 47 IS 13 BP 8377 EP 8380 DI 10.1103/PhysRevB.47.8377 PG 4 WC Physics, Condensed Matter SC Physics GA KW310 UT WOS:A1993KW31000101 ER PT J AU KLEINSCHMIDT, JC MARDEN, LJ KENT, D QUIGLEY, N HOLLINGER, JO AF KLEINSCHMIDT, JC MARDEN, LJ KENT, D QUIGLEY, N HOLLINGER, JO TI A MULTIPHASE SYSTEM BONE IMPLANT FOR REGENERATING THE CALVARIA SO PLASTIC AND RECONSTRUCTIVE SURGERY LA English DT Article ID GUIDED TISSUE REGENERATION AB The regeneration of bone with a biodegradable, biocompatible carrier and osteo-regenerative proteins may be possible if the carrier has the appropriate architecture to support osteoconduction and prevent soft-tissue prolapse into ablated bone segments. Using radiomorphometry and histomorphometry, our group assessed individually and combined the components of a multiphase system bone implant (MSI) in rabbit cranial defects (critical-size defects: CSDs): two disks of biodegradable polymer (PLG) and demineralized bone matrix (DBM), a recognized osteo-regenerative material. We used 48 rabbits evenly divided between four treatment groups and two time periods. Six weeks after treatment, both DBM and PLG had significant positive effects on bone regeneration (based on a three-factor analysis of variance, p < 0.05). These effects were synergistic when the components were combined (MSI). Defects treated with DBM or PLG alone continued to regenerate bone through 12 weeks. By this time, bone within the defects treated with MSI appeared to be maturing and consolidating. We conclude that the concept of placing osteo-regenerative factors between two biodegradable disks for regenerating segments of calvaria is viable. C1 WALTER REED ARMY MED CTR,USAIDR,WASHINGTON,DC 20307. UNIV ARKANSAS MED SCI HOSP,LITTLE ROCK,AR 72205. NR 26 TC 39 Z9 39 U1 0 U2 1 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0032-1052 J9 PLAST RECONSTR SURG JI Plast. Reconstr. Surg. PD APR PY 1993 VL 91 IS 4 BP 581 EP 588 DI 10.1097/00006534-199304000-00002 PG 8 WC Surgery SC Surgery GA KT700 UT WOS:A1993KT70000002 PM 8446710 ER PT J AU TSENG, HH LAI, FS LEE, CK AF TSENG, HH LAI, FS LEE, CK TI PNEUMATIC BURSTING CHARACTERISTICS OF PLASTICS FILMS SO POLYMER ENGINEERING AND SCIENCE LA English DT Article AB The bursting strength and inflated deflection of linear low density polyethylene (LLDPE), oriented polypropylene (OPP), flexible poly(vinyl chloride) (PVC), poly(ethylene terephthalate) (PET), and polyurethane (PUR) films of different thicknesses were investigated with the pneumatic bursting method. The study showed the bursting air pressure is directly proportional to the thickness of LLDPE, OPP, and PET films. The effect of different membrane diameters on the change of the bursting properties in OPP and PUR film was also investigated. The results showed that the bursting properties are inversely proportional to the membrane diameter. Furthermore, biaxial stress-strain exerted on the pole region of the tested films was studied. The results denoted that the relationship between the biaxial and uniaxial tensile stress-strain was considered for two types of film: 1) Film that presented an isotropic tensile behavior showed that the tangential stress-strain is higher than the tensile stress-strain. 2) Film that presented an anisotropic tensile behavior showed that the tangential stress-strain is determined by the weaker tensile stress-strain values between two directions. C1 UNIV MASSACHUSETTS,DEPT PLAST ENGN,LOWELL,MA 01854. USA,NATICK RES DEV & ENGN CTR,NATICK,MA 01760. NR 5 TC 1 Z9 1 U1 0 U2 0 PU SOC PLASTICS ENG INC PI BROOKFIELD CENTER PA 14 FAIRFIELD DR, BROOKFIELD CENTER, CT 06804-0403 SN 0032-3888 J9 POLYM ENG SCI JI Polym. Eng. Sci. PD APR PY 1993 VL 33 IS 8 BP 504 EP 512 DI 10.1002/pen.760330810 PG 9 WC Engineering, Chemical; Polymer Science SC Engineering; Polymer Science GA KY578 UT WOS:A1993KY57800009 ER PT J AU KADAKIA, SC AF KADAKIA, SC TI COPING WITH ACHALASIA SO POSTGRADUATE MEDICINE LA English DT Article ID ESOPHAGEAL ACHALASIA; PNEUMATIC DILATATION; VIGOROUS ACHALASIA; DOUBLE-BLIND; NIFEDIPINE; DILATION; EXPERIENCE; DILATORS; PLACEBO AB Achalasia is a primary esophageal motor disorder that is characterized by dysphagia, regurgitation, and chest pain. The diagnosis is suggested by narrowing with the classic ''bird's beak'' appearance of the distal esophagus. Esophageal manometry showing aperistalsis confirms the diagnosis. Pseudoachalasia must be excluded with endoscopy. Pneumatic dilatation is the treatment of choice. Surgical myotomy is reserved for patients in whom repeated pneumatic dilatation fails. RP KADAKIA, SC (reprint author), USA,DEPT MED,GASTROENTEROL SECT,BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234, USA. NR 30 TC 1 Z9 1 U1 0 U2 0 PU MCGRAW HILL HEALTHCARE PUBLICATIONS PI MINNEAPOLIS PA 4530 WEST 77TH ST, MINNEAPOLIS, MN 55435-5000 SN 0032-5481 J9 POSTGRAD MED JI Postgrad. Med. PD APR PY 1993 VL 93 IS 5 BP 249 EP & PG 0 WC Medicine, General & Internal SC General & Internal Medicine GA KW829 UT WOS:A1993KW82900016 PM 8460081 ER PT J AU JONES, KF AF JONES, KF TI ANOTHER LOOK AT THE DEPENDENCE OF ICE ACCRETION DENSITY ON NONDIMENSIONAL PARAMETERS - REPLY SO QUARTERLY JOURNAL OF THE ROYAL METEOROLOGICAL SOCIETY LA English DT Note AB In response to the comments of Levi and Prodi I have made a comparison between their rime density data and a similar subset of my data. The choice of air temperature rather than accretion temperature to characterize droplet freezing is further explained, and the convective-heat-flux pi-product is modified by using the droplet diameter rather than the cylinder diameter as the length scale. A limitation to the regression analysis associated with the form of the function relating ice density to non-dimensional parameters associated with ice accretion is discussed. RP JONES, KF (reprint author), USA,COLD REG RES & ENGN LAB,HANOVER,NH 03755, USA. NR 5 TC 0 Z9 0 U1 0 U2 1 PU ROYAL METEOROLOGICAL SOC PI READING PA 104 OXFORD ROAD, READING, BERKS, ENGLAND RG1 7LJ SN 0035-9009 J9 Q J ROY METEOR SOC JI Q. J. R. Meteorol. Soc. PD APR PY 1993 VL 119 IS 511 BP 605 EP 609 PG 5 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA LB114 UT WOS:A1993LB11400014 ER PT J AU HANDLEY, JW JAENISCH, HM BJORK, CA RICHARDSON, LT CARRUTH, RT AF HANDLEY, JW JAENISCH, HM BJORK, CA RICHARDSON, LT CARRUTH, RT TI CHAOS AND FRACTAL ALGORITHMS APPLIED TO SIGNAL-PROCESSING AND ANALYSIS SO SIMULATION LA English DT Article DE CHAOS; FRACTALS; R-S; AIPS; SYNERGETICS; SIGNAL PROCESSING AB Modern signal processing methods strive to maximize signal to noise ratios, even in the presence of severe noise. Frequently, real world data is degraded by under sampling of intrinsic periodicities, or by sampling with unevenly spaced intervals. This results in dropout or missing data, and such data sets are particularly difficult to process using conventional methods. In many cases, one must still extract as much information as possible from a given data set, although the available discrete data is sparse or very noisy. In such cases, we have found the algorithms derived from Chaos and fractal theory to represent a viable alternative to traditional spectral analysis. The data analysis techniques discussed in this work include phase space reconstruction, Poincare projections radius of gyration exponent, artificial insymmetration patterns (AIP), Liapunov spectra, correlation techniques, R/S analysis, K-factor, fractal statistics, maximum entropy method, and wavelets. C1 NICHOLS RES CORP,HUNTSVILLE,AL 35802. UNIV ALABAMA,DEPT MECH ENGN,UNIVERSITY,AL 35486. USA,STRATEG DEF COMMAND,HUNTSVILLE,AL 35807. NR 53 TC 11 Z9 11 U1 0 U2 1 PU SIMULATION COUNCILS INC PI SAN DIEGO PA PO BOX 17900, SAN DIEGO, CA 92117 SN 0037-5497 J9 SIMULATION JI Simulation PD APR PY 1993 VL 60 IS 4 BP 261 EP 278 DI 10.1177/003754979306000407 PG 18 WC Computer Science, Interdisciplinary Applications; Computer Science, Software Engineering SC Computer Science GA MX097 UT WOS:A1993MX09700006 ER PT J AU SOMMERS, RJ AF SOMMERS, RJ TI THE CIVIL-WAR MEMOIRS OF SEYMOUR,WILLIAM,J. - REMINISCENCES OF A LOUISIANA TIGER - JONES,TL SO SOUTHWESTERN HISTORICAL QUARTERLY LA English DT Book Review RP SOMMERS, RJ (reprint author), USA,INST MIL HIST,WASHINGTON,DC 20310, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU TEXAS STATE HIST ASSN PI AUSTIN PA 2/306 RICHARDSON HALL UNIV STATION, AUSTIN, TX 78712 SN 0038-478X J9 SOUTHWEST HIST QUART JI Southw. Hist. Q. PD APR PY 1993 VL 96 IS 4 BP 617 EP 618 PG 2 WC History SC History GA KY626 UT WOS:A1993KY62600031 ER PT J AU SOKOL, MS KAVOLIUS, J SCHAAF, M DAVIS, J AF SOKOL, MS KAVOLIUS, J SCHAAF, M DAVIS, J TI RECURRENT HYPERPARATHYROIDISM FROM BENIGN NEOPLASTIC SEEDING - A REVIEW WITH RECOMMENDATIONS FOR MANAGEMENT SO SURGERY LA English DT Note ID POSTMENOPAUSAL WOMEN; PARATHYROID TISSUE; REOPERATION; FAILURE AB Benign neoplastic seeding represents a rare cause of hyperparathyroidism found at parathyroid reoperations. It consists of pathologically benign neoplastic parathyroid tissue scattered throughout a previous parathyroid surgical site. We describe a case of recurrent and then persistent hyperparathyroidism occurring in a patient during an 18-year period. The patient's third operation showed nonmalignant parathyroid tissue throughout the right neck bed, which necessitated extensive parathyroid and fibrofatty tissue dissection and a thyroidectomy. This unexpected finding of extensive parathyroid seeding has only been described in detail in ten other patients in the past. A review of these 11 patients shows several features: initial operations were for large parathyroid tumors or cysts in six patients; rupture and spillage of contents occurred in six; and initial hypercalcemia was severe in several patients, perhaps indicating inherently more aggressive tumors. The appearance of benign neoplastic seeding resembled parathyroid carcinoma in its local invasiveness. Therefore the presence of anaplasia, mitoses, capsular invasion, and cellular spindling must be relied on as distinguishing factors. When confronted with this presentation, we recommend removal of all nodal bearing, thyroid, and fibrofatty tissue from the level of the thyroid cartilage to the superior mediastinum and a thyroidectomy if necessary. C1 WALTER REED ARMY MED CTR,DEPT MED,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT SURG,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. NR 19 TC 25 Z9 25 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0039-6060 J9 SURGERY JI Surgery PD APR PY 1993 VL 113 IS 4 BP 456 EP 461 PG 6 WC Surgery SC Surgery GA KV572 UT WOS:A1993KV57200013 PM 8456402 ER PT J AU HOGAN, AW GOW, AJ AF HOGAN, AW GOW, AJ TI PARTICLE-TRANSPORT TO THE SNOW SURFACE AT THE SOUTH-POLE - THE BEGINNING OF A TROPOSPHERIC HISTORY SO TELLUS SERIES B-CHEMICAL AND PHYSICAL METEOROLOGY LA English DT Article AB Sodium concentration measurements in recent south polar snow by Legrand and Kirchener have been compared with surface aerosol measurements by Bodhaine, Shanahan and Samson et al., made at the South Pole Station. When a 180-day lag is applied, to allow spring/summer aerosols to be precipitated and incorporated into the autumn/winter snow layer, very good correspondence exists between mean aerosol concentration in air and mean sodium concentration in snow. This paper describes analyses of meteorological and glaciological processes to define glaciological and meteorological years, which justify the use of this 180 day lag. The accumulation rate of snow on the South Polar Plateau has been established through pit and core analysis during the occupation of the South Pole station, and through direct snow stake accumulation measurement. Precipitation has not been routinely measured, but is estimated through analysis of the station meteorological record and application of the cold air precipitation rates derived from the literature. The estimated precipitation is compared with measured accumulation to investigate lag between time of precipitation and accumulation, and to examine other possible sources of accumulated ice substance (riming, drifting, and direct sublimation) to define the glaciological year. Precipitation of sodium and other particles, through coagulation and other ice crystal attachment processes, is discussed relative to the meteorological year. The results of this work indicate that additional measurements relative to the gradients of temperature, wind, precipitation, and accumulation on the Polar Plateau are essential to the formal establishment of a theory relating glacio-chemical accumulation to meteorological processes, and formulating tropospheric history from glacial deposition. RP HOGAN, AW (reprint author), USA,COLD REG RES & ENGN LAB,HANOVER,NH 03755, USA. NR 0 TC 9 Z9 9 U1 0 U2 0 PU MUNKSGAARD INT PUBL LTD PI COPENHAGEN PA 35 NORRE SOGADE, PO BOX 2148, DK-1016 COPENHAGEN, DENMARK SN 0280-6509 J9 TELLUS B JI Tellus Ser. B-Chem. Phys. Meteorol. PD APR PY 1993 VL 45 IS 2 BP 188 EP 207 DI 10.1034/j.1600-0889.1993.00010.x PG 20 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA KZ273 UT WOS:A1993KZ27300010 ER PT J AU VONWINDHEIM, JA SIVAZLIAN, F MCCLURE, MT GLASS, JT PRATER, JT AF VONWINDHEIM, JA SIVAZLIAN, F MCCLURE, MT GLASS, JT PRATER, JT TI NUCLEATION AND GROWTH OF DIAMOND USING A COMPUTER-CONTROLLED OXY-ACETYLENE TORCH SO DIAMOND AND RELATED MATERIALS LA English DT Article; Proceedings Paper CT DIAMOND 92 - 3RD INTERNATIONAL CONF ON THE NEW DIAMOND SCIENCE AND TECHNOLOGY / 3RD EUROPEAN CONF ON DIAMOND, DIAMOND-LIKE AND RELATED COMPOUNDS CY AUG 31-SEP 04, 1992 CL HEIDELBERG, GERMANY SP NORTON DIAMOND FILM, NORTHBORO RES CTR, DIAMOND & RELATED MAT, MONSANTO EUROPE, DRUKKER INT, JAPAN NEW DIAMOND FORUM, COMMISS EUROPEAN COMMUNITIES, KOBEL STEEL, MITSUBISHI MAT, SUMIMOTO ELECT IND, DE BEERS IND DIAMOND DIV ID FLAME; FILMS AB A computer-controlled oxy-acetylene torch was used to nucleate and grow polycrystalline diamond films. The computer interface was designed to monitor and/or modify continuously oxygen and acetylene flow rates, while a PID temperature controller was used to stabilize the substrate temperature at selected set points. This system significantly enhanced the control and reproducibility of the diamond growth, leading to increased area (50 mm2), high quality diamond films. A pretreatment was used to enhance the nucleation of diamond. This pretreatment involved an oxygen-to-acetylene ratio of 0.93-0.95, with the substrate about 15 mm from the torch nozzle. Surface analysis revealed that diamond was deposited in as little as 30 s with a significant amount of carbon being incorporated in the sp2 form. When the substrate was subsequently moved up into the flame and the oxygen-to-acetylene ratio was increased, good quality diamond was observed to deposit on the pretreated area over the entire area of the flame front. Utilizing computer control, systematic and complex variations in gas chemistry could be applied during growth. Thus, the oxygen-to-acetylene ratio was modified between 0.97 and 1.01 using a sawtooth function, resulting in larger grain sizes relative to normal growth conditions, with very little sp2 bonding. C1 USA,RES OFF,DIV MAT SCI,RES TRIANGLE PK,NC 27709. RP VONWINDHEIM, JA (reprint author), N CAROLINA STATE UNIV,DIAMOND DEPOSIT & ANAL LAB,RES BLDG 1,CENTENNIAL CAMPUS,RALEIGH,NC 27695, USA. RI Glass, Jeffrey/A-2266-2010 OI Glass, Jeffrey/0000-0002-9554-4398 NR 12 TC 7 Z9 7 U1 0 U2 0 PU ELSEVIER SCIENCE SA LAUSANNE PI LAUSANNE 1 PA PO BOX 564, 1001 LAUSANNE 1, SWITZERLAND SN 0925-9635 J9 DIAM RELAT MATER JI Diam. Relat. Mat. PD MAR 31 PY 1993 VL 2 IS 2-4 BP 438 EP 442 DI 10.1016/0925-9635(93)90097-L PG 5 WC Materials Science, Multidisciplinary SC Materials Science GA LE620 UT WOS:A1993LE62000068 ER PT J AU KIM, JH VAHEY, MT MCLINDEN, RJ MOSCA, JD BURKE, DS REDFIELD, RR AF KIM, JH VAHEY, MT MCLINDEN, RJ MOSCA, JD BURKE, DS REDFIELD, RR TI CONSEQUENCES OF HIV-1 SUPERINFECTION OF CHRONICALLY INFECTED-CELLS SO JOURNAL OF CELLULAR BIOCHEMISTRY LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,DEPT RETROVIRAL RES,WASHINGTON,DC 20307. WALTER REED ARMY INST RES,DIV RETROVIROL,WASHINGTON,DC 20307. HENRY M JACKSON FDN,ROCKVILLE,MD 20850. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0730-2312 J9 J CELL BIOCHEM JI J. Cell. Biochem. PD MAR 29 PY 1993 SU 17E BP 50 EP 50 PG 1 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA KX965 UT WOS:A1993KX96500182 ER PT J AU MICHAEL, NL EHRENBERG, PK DARCY, L VAHEY, MT MOSCA, JD RAPPAPORT, J REDFIELD, RR AF MICHAEL, NL EHRENBERG, PK DARCY, L VAHEY, MT MOSCA, JD RAPPAPORT, J REDFIELD, RR TI NEGATIVE-STRAND TRANSCRIPTS ARE PRODUCED IN HIV-1 INFECTED-CELLS AND PATIENTS BY A NOVEL PROMOTER DOWN-REGULATED BY TAT SO JOURNAL OF CELLULAR BIOCHEMISTRY LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,DEPT RETROVIRAL RES,WASHINGTON,DC 20307. HENRY M JACKSON FDN,ROCKVILLE,MD 20850. NIDR,ORAL MED LAB,BETHESDA,MD 20852. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0730-2312 J9 J CELL BIOCHEM JI J. Cell. Biochem. PD MAR 29 PY 1993 SU 17E BP 52 EP 52 PG 1 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA KX965 UT WOS:A1993KX96500188 ER PT J AU ROBB, ML RUDERMAN, J MICHAEL, NL CIESLAK, T REDFIELD, RR AF ROBB, ML RUDERMAN, J MICHAEL, NL CIESLAK, T REDFIELD, RR TI COMPARISON OF HIV ENV SEQUENCE VARIATION FROM UNCULTURED LYMPH-NODE AND SERIAL BLOOD-SAMPLES SO JOURNAL OF CELLULAR BIOCHEMISTRY LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,ROCKVILLE,MD 20850. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0730-2312 J9 J CELL BIOCHEM JI J. Cell. Biochem. PD MAR 29 PY 1993 SU 17E BP 54 EP 54 PG 1 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA KX965 UT WOS:A1993KX96500199 ER PT J AU CARTER, JM KATZHENDLER, J WASSEF, N ALVING, C DOCTOR, BP AF CARTER, JM KATZHENDLER, J WASSEF, N ALVING, C DOCTOR, BP TI ANTIBODIES AGAINST CD4 PEPTIDES BLOCK BINDING OF GP120 TO NATIVE CD4 SO JOURNAL OF CELLULAR BIOCHEMISTRY LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,DIV BIOCHEM,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0730-2312 J9 J CELL BIOCHEM JI J. Cell. Biochem. PD MAR 29 PY 1993 SU 17E BP 60 EP 60 PG 1 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA KX965 UT WOS:A1993KX96500220 ER PT J AU VANCOTT, TC POLONIS, VR BETHKE, FR JACIR, NE SMITH, G REDFIELD, RR BIRX, DL AF VANCOTT, TC POLONIS, VR BETHKE, FR JACIR, NE SMITH, G REDFIELD, RR BIRX, DL TI CONTRIBUTION OF ANTIBODIES DIRECTED TOWARDS LINEAR AND CONFORMATIONAL EPITOPES INDUCED BY MICROGENESIS GP160(LAI) AND GENENTECH GP120(IIIB) VACCINATION OF HIV-1 INFECTED INDIVIDUALS SO JOURNAL OF CELLULAR BIOCHEMISTRY LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,DEPT RETROVIRAL RES,WASHINGTON,DC 20307. HENRY M JACKSON FDN,ROCKVILLE,MD 20850. MICROGENES INC,W HAVEN,CT 06516. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0730-2312 J9 J CELL BIOCHEM JI J. Cell. Biochem. PD MAR 29 PY 1993 SU 17E BP 87 EP 87 PG 1 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA KX965 UT WOS:A1993KX96500327 ER PT J AU WEIR, JP ELKINS, KL AF WEIR, JP ELKINS, KL TI INHIBITION OF HIV REPLICATION IN HUMAN MONOCYTES BY DEFECTIVE HERPESVIRUS VECTOR DELIVERY OF AN INTERFERON-ALPHA GENE SO JOURNAL OF CELLULAR BIOCHEMISTRY LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,HENRY M JACKSON FDN,DEPT CELLULAR IMMUNOL,ROCKVILLE,MD 20850. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0730-2312 J9 J CELL BIOCHEM JI J. Cell. Biochem. PD MAR 29 PY 1993 SU 17E BP 92 EP 92 PG 1 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA KX965 UT WOS:A1993KX96500346 ER PT J AU LASA, C HOLLINGER, J KIDD, R NUNEZ, H HAUDENSCHILD, C DROHAN, W MACPHEE, M AF LASA, C HOLLINGER, J KIDD, R NUNEZ, H HAUDENSCHILD, C DROHAN, W MACPHEE, M TI OSTEOREGENERATION USING A FIBRIN SEALANT DELIVERY VEHICLE FOR DEMINERALIZED BONE-MATRIX SO JOURNAL OF CELLULAR BIOCHEMISTRY LA English DT Meeting Abstract C1 AMER RED CROSS,HOLLAND LAB,ROCKVILLE,MD 20855. USA,INST DENT RES,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0730-2312 J9 J CELL BIOCHEM JI J. Cell. Biochem. PD MAR 29 PY 1993 SU 17E BP 162 EP 162 PG 1 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA KX965 UT WOS:A1993KX96500576 ER PT J AU CARROLL, R LIN, JT KIM, J MOSCA, J VAHEY, M BURKE, D LOUIS, DS AF CARROLL, R LIN, JT KIM, J MOSCA, J VAHEY, M BURKE, D LOUIS, DS TI CONSTRUCTION AND CHARACTERIZATION OF REPLICATION-DEFECTIVE HIV-1 PACKAGING CELL-LINES SO JOURNAL OF CELLULAR BIOCHEMISTRY LA English DT Meeting Abstract C1 HENRY M JACKSON FDN,ROCKVILLE,MD 20850. WALTER REED ARMY INST RES,DIV RETROVIRAL RES,ROCKVILLE,MD 20850. WALTER REED ARMY INST RES,DIV RETROVIROL,ROCKVILLE,MD 20850. MIL CONSORTIUM APPL RETROVIRAL RES,ROCKVILLE,MD 20850. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0730-2312 J9 J CELL BIOCHEM JI J. Cell. Biochem. PD MAR 29 PY 1993 SU 17E BP 241 EP 241 PG 1 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA KX965 UT WOS:A1993KX96500855 ER PT J AU KAUSHAL, S GARTNER, S LARUSSA, S LIU, Y YU, Z RITCHEY, D XU, J PERERA, P AF KAUSHAL, S GARTNER, S LARUSSA, S LIU, Y YU, Z RITCHEY, D XU, J PERERA, P TI HIV-1 EXPRESSION IN HUMAN STROMAL CELLS DOES NOT EFFECT CYTOKINES PRODUCTION SO JOURNAL OF CELLULAR BIOCHEMISTRY LA English DT Meeting Abstract C1 JACKSON FDN,ROCKVILLE,MD 20850. WALTER REED ARMY INST RES,ROCKVILLE,MD 20850. NIH,BETHESDA,MD 20894. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0730-2312 J9 J CELL BIOCHEM JI J. Cell. Biochem. PD MAR 29 PY 1993 SU 17E BP 243 EP 243 PG 1 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA KX965 UT WOS:A1993KX96500863 ER PT J AU MURPHY, SB AMYLON, M LINK, MP BOWMAN, WP BRECHER, M PICK, T BERARD, CW HUTCHINSON, R SHUSTER, JJ AF MURPHY, SB AMYLON, M LINK, MP BOWMAN, WP BRECHER, M PICK, T BERARD, CW HUTCHINSON, R SHUSTER, JJ TI RECENT ADVANCES IN THERAPY OF HIGH-GRADE T-CELL AND B-CELL NON-HODGKINS-LYMPHOMAS (NHL) OF CHILDHOOD SO JOURNAL OF CELLULAR BIOCHEMISTRY LA English DT Meeting Abstract C1 COOK CHILDRENS HOSP, FT WORTH, TX USA. STANFORD UNIV, STANFORD, CA 94305 USA. ST JUDE CHILDRENS RES HOSP, MEMPHIS, TN 38101 USA. BROOKE ARMY MED CTR, FT SAM HOUSTON, TX 78234 USA. NEW YORK STATE DEPT HLTH, ROSWELL PK MEM INST, BUFFALO, NY 14263 USA. UNIV FLORIDA, GAINESVILLE, FL 32611 USA. CHILDRENS MEM HOSP, PEDIAT ONCOL GRP, CHICAGO, IL 60614 USA. SUNY COLL SYRACUSE, SYRACUSE, NY USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0730-2312 J9 J CELL BIOCHEM JI J. Cell. Biochem. PD MAR 29 PY 1993 SU 17E BP 257 EP 257 PG 1 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA KX965 UT WOS:A1993KX96500907 ER PT J AU KIM, HJ HAERING, C AF KIM, HJ HAERING, C TI EVALUATION OF PROTEIN CROSS-LINKING AND BIODEGRADABILITY BY REVERSED PHASE HPLC DETERMINATION OF TRYPTOPHAN RELEASED BY PRONASE SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,NATICK RD&E CTR,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 28 PY 1993 VL 205 BP 11 EP AGFD PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA KQ981 UT WOS:A1993KQ98100011 ER PT J AU LECHNER, B SLOOP, JC LOEHLE, WD AF LECHNER, B SLOOP, JC LOEHLE, WD TI INVESTIGATION OF THE KINETICS AND DETERMINATION OF HAMMETT RHO VALUES FOR PYRAZOLE FORMATION SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 US MIL ACAD,DEPT CHEM,W POINT,NY 10996. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 28 PY 1993 VL 205 BP 11 EP AGRO PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA KQ981 UT WOS:A1993KQ98100124 ER PT J AU SLOOP, JC BUMGARDNER, CL AF SLOOP, JC BUMGARDNER, CL TI SYNTHESIS OF FLUORINATED HETEROCYCLES SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 US MIL ACAD,DEPT CHEM,W POINT,NY 10996. N CAROLINA STATE UNIV,DEPT CHEM,RALEIGH,NC 27695. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 28 PY 1993 VL 205 BP 12 EP AGRO PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA KQ981 UT WOS:A1993KQ98100125 ER PT J AU COHEN, JM FAMINI, GR AF COHEN, JM FAMINI, GR TI APPLICATION OF THE EIKONAL METHOD TO RO-VIBRATIONALLY INELASTIC-COLLISIONS SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,ERDEC,SMCCR RSP C,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 28 PY 1993 VL 205 BP 15 EP COMP PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA KQ981 UT WOS:A1993KQ98101667 ER PT J AU VONTERSCH, RL URBAN, JJ FAMINI, GR AF VONTERSCH, RL URBAN, JJ FAMINI, GR TI COMPUTATIONAL STUDIES OF THE AQUEOUS PHASE CONFORMATION OF FLUOROTYROSINES SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,ERDEC,SCBRD RTS,ABERDEEN PROVING GROUND,MD 21010. USA,MED RES INST CHEM DEF,SGRD UV PB,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 28 PY 1993 VL 205 BP 17 EP COMP PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA KQ981 UT WOS:A1993KQ98101669 ER PT J AU XU, X KARAYIGITOGLU, C GONZALEZ, RD JOHN, VT AKKARA, J KAPLAN, D AF XU, X KARAYIGITOGLU, C GONZALEZ, RD JOHN, VT AKKARA, J KAPLAN, D TI THE BIOMIMETICS OF ENZYME-CATALYZED POLYMERIZATIONS IN MICROSTRUCTURED FLUID MEDIA SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,CTR RES DEV & EDUC,NATICK,MA 01760. TULANE UNIV,DEPT CHEM ENGN,NEW ORLEANS,LA 70118. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 28 PY 1993 VL 205 BP 17 EP BTEC PN 2 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA KQ983 UT WOS:A1993KQ98301560 ER PT J AU BALL, DH AF BALL, DH TI CHEMICAL MODIFICATION OF STARCH UNDER HOMOGENEOUS CONDITIONS - EFFECTS ON BIODEGRADABILITY SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,NATICK RD&E CTR,DIV BIOTECHNOL,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 28 PY 1993 VL 205 BP 23 EP CARB PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA KQ981 UT WOS:A1993KQ98100535 ER PT J AU DONOVAN, WH FAMINI, GR AF DONOVAN, WH FAMINI, GR TI MOLECULAR-ORBITAL STUDY OF SULFUR MUSTARD AND ITS REACTIONS WITH HYDROXIDE ANION SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,EDGEWOOD RES DEV & ENGN CTR,SCBRD RTS,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 28 PY 1993 VL 205 BP 47 EP COMP PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA KQ981 UT WOS:A1993KQ98101699 ER PT J AU FAMINI, GR BARTRAM, PW AF FAMINI, GR BARTRAM, PW TI PREDICTING OXIDATION SIMILARITIES BETWEEN VX AND POTENTIAL SIMULANTS BY SEMIEMPIRICAL ORBITAL CALCULATIONS SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,CTR CHEM RES DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 28 PY 1993 VL 205 BP 48 EP COMP PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA KQ981 UT WOS:A1993KQ98101700 ER PT J AU MUNAVALLI, S ROSSMAN, DI ROHRBAUGH, DK FERGUSON, CP BUETTNER, L AF MUNAVALLI, S ROSSMAN, DI ROHRBAUGH, DK FERGUSON, CP BUETTNER, L TI SYNTHESIS AND BIOLOGICAL SCREENING OF TRIFLUOROMETHYLTHIOARSENICALS SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 GEOCENTERS INC,FT WASHINGTON,MD 20774. USA,CTR CHEM RES DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 28 PY 1993 VL 205 BP 79 EP ORGN PN 2 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA KQ983 UT WOS:A1993KQ98300215 ER PT J AU MAXWELL, DM LIESKE, CN BRECHT, KM AF MAXWELL, DM LIESKE, CN BRECHT, KM TI OXIME-INDUCED REACTIVATION OF CARBOXYLESTERASE INHIBITED BY ORGANOPHOSPHORUS COMPOUNDS SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,MRICD,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 28 PY 1993 VL 205 BP 84 EP AGRO PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA KQ981 UT WOS:A1993KQ98100195 ER PT J AU LIESKE, CN CLARK, JH MAXWELL, DM BLUMBERGS, P KNUTSON, P AF LIESKE, CN CLARK, JH MAXWELL, DM BLUMBERGS, P KNUTSON, P TI ORIENTATION IN PHOSPHONYLATION - CHOLINESTERASE STUDIES WITH S-2-N,N-DIETHYL-N-METHYLAMMONIUMETHYL O-PINACOLYL METHYLPHOSPHONOTHIOATE METHYLSULFATE SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,MRICD,ABERDEEN PROVING GROUND,MD 21010. ASH STEVENS INC,DETROIT,MI 48202. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 28 PY 1993 VL 205 BP 87 EP AGRO PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA KQ981 UT WOS:A1993KQ98100198 ER PT J AU FAMINI, GR WILSON, LY AF FAMINI, GR WILSON, LY TI APPLICATIONS OF THEORETICAL DESCRIPTORS IN QUANTITATIVE STRUCTURE-ACTIVITY-RELATIONSHIPS SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,CHEM RES,CTR DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010. LA SIERRA UNIV,DEPT CHEM,RIVERSIDE,CA 92515. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 28 PY 1993 VL 205 BP 88 EP AGFD PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA KQ981 UT WOS:A1993KQ98100088 ER PT J AU HSIEH, AJ PERGANTIS, CG AF HSIEH, AJ PERGANTIS, CG TI DURABILITY OF DIAMOND-LIKE CARBON COATED POLYCARBONATES SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,RES LAB,POLYMER RES BRANCH,AMSRL,MA,PB,WATERTOWN,MA 02172. USA,RES LAB,COMPOSITE DEV BRANCH,AMSRL,MA,PA,WATERTOWN,MA 02172. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 28 PY 1993 VL 205 BP 92 EP PMSE PN 2 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA KQ983 UT WOS:A1993KQ98301432 ER PT J AU CHEN, MF VEZZOLI, GC AF CHEN, MF VEZZOLI, GC TI CHEMICAL PREPARATION OF NANACOMPOSITE AU/SIO2 GEL AND MN/SIO2 GEL FOR HIGH DIELECTRIC STRENGTH MATERIALS SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,RES LAB,DIV CERAM,WATERTOWN,MA 02172. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 28 PY 1993 VL 205 BP 97 EP INOR PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA KQ981 UT WOS:A1993KQ98102449 ER PT J AU KARAYIGITOGLU, CF XU, XD WEBB, PR JOHN, VT GONZALEZ, RD AKKARA, JA KAPLAN, DL AF KARAYIGITOGLU, CF XU, XD WEBB, PR JOHN, VT GONZALEZ, RD AKKARA, JA KAPLAN, DL TI ENZYME-CATALYZED POLYMERIZATION IN WATER-IN-OIL MICROEMULSIONS - A STUDY ON POLYMER MORPHOLOGY SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 TULANE UNIV,DEPT CHEM ENGN,NEW ORLEANS,LA 70118. USA,NATICK RES DEV & ENGN CTR,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 28 PY 1993 VL 205 BP 99 EP PMSE PN 2 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA KQ983 UT WOS:A1993KQ98301439 ER PT J AU MCGRATH, KP KAPLAN, DL AF MCGRATH, KP KAPLAN, DL TI CONTROL OF MOLECULAR-ORGANIZATION IN PROTEIN-BASED MATERIALS SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,NATICK RD&E CTR,DIV BIOTECHNOL,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 28 PY 1993 VL 205 BP 201 EP POLY PN 2 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA KQ983 UT WOS:A1993KQ98301051 ER PT J AU URBAN, JJ FAMINI, GR AF URBAN, JJ FAMINI, GR TI THEORETICAL-STUDIES OF THE CONFORMATION OF DOPAMINE AND STRUCTURAL ANALOGS SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,CTR DEV & ENGN,EDGEWOOD RES,SCBRD RTS,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 28 PY 1993 VL 205 BP 210 EP ORGN PN 2 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA KQ983 UT WOS:A1993KQ98300346 ER PT J AU BEAUDRY, WT WAGNER, GW WARD, JR AF BEAUDRY, WT WAGNER, GW WARD, JR TI EFFECT OF METAL-IONS ON THE HYDROLYSIS OF ORGANOPHOSPHORUS ESTERS ON STRONG-BASE ION-EXCHANGE RESINS SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,EDGEWOOD RD&E CTR,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 28 PY 1993 VL 205 BP 300 EP INOR PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA KQ981 UT WOS:A1993KQ98102652 ER PT J AU JAGLOWSKI, AJ SINGLER, RE AF JAGLOWSKI, AJ SINGLER, RE TI SYNTHESIS AND CHARACTERIZATION OF POLYPHOSPHAZENES FOR POTENTIAL ELECTROOPTICAL APPLICATIONS SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,RES LAB,WATERTOWN,MA 02172. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 28 PY 1993 VL 205 BP 307 EP POLY PN 2 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA KQ983 UT WOS:A1993KQ98301157 ER PT J AU MUNAVALLI, S ROSSMAN, DI LEWIS, EO MULLER, AJ ROHRBAUGH, DK FERGUSON, CP AF MUNAVALLI, S ROSSMAN, DI LEWIS, EO MULLER, AJ ROHRBAUGH, DK FERGUSON, CP TI NEW REACTIONS OF PERFLUOROISOBUTYLENE SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 GEOCENTERS INC,FT WAHINGTON,MD 20744. USA,CTR DEV & ENGN,EDGEWOOD CHEM RES,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 28 PY 1993 VL 205 BP 341 EP ORGN PN 2 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA KQ983 UT WOS:A1993KQ98300477 ER PT J AU MAYER, JM ALLEN, AL DELL, PA MCCASSIE, JE SHUPE, AE STENHOUSE, PJ WELCH, EA KAPLAN, DL AF MAYER, JM ALLEN, AL DELL, PA MCCASSIE, JE SHUPE, AE STENHOUSE, PJ WELCH, EA KAPLAN, DL TI DEVELOPMENT OF BIODEGRADABLE MATERIALS - BALANCING DEGRADABILITY AND PERFORMANCE SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,NATICK RES DEV & ENGN CTR,DIV BIOTECHNOL,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 2 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD MAR 28 PY 1993 VL 205 BP 466 EP POLY PN 2 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA KQ983 UT WOS:A1993KQ98301317 ER PT J AU YUEN, DA HANSEN, U ZHAO, W VINCENT, AP MALEVSKY, AV AF YUEN, DA HANSEN, U ZHAO, W VINCENT, AP MALEVSKY, AV TI HARD TURBULENT THERMAL-CONVECTION AND THERMAL EVOLUTION OF THE MANTLE SO JOURNAL OF GEOPHYSICAL RESEARCH-PLANETS LA English DT Review ID INFINITE-PRANDTL-NUMBER; TIME-DEPENDENT CONVECTION; RAYLEIGH-BENARD CONVECTION; EARTHS MANTLE; CHAOTIC CONVECTION; PHASE-TRANSITIONS; BOUNDARY-LAYERS; HIGH-PRESSURE; HELIUM-GAS; TEMPERATURE AB This article summarizes the results of hard turbulent convection obtained in laboratory experiments and numerical simulations. Its applications to mantle convection are illustrated by two-dimensional numerical solutions to (1) Newtonian, (2) non-Newtonian convection and (3) Newtonian convection with multiple phase transitions. In Newtonian mantle convection the transition from soft to hard turbulence is marked by the appearance of disconnected plumes. Spectral analysis of the time series of the Nusselt number reveals the presence of a spectral scaling subrange for hard turbulence but not for soft turbulence. In hard turbulence there is correspondence between the spectra in frequency and wavenumber domains. The slope of the seismic wave spectra measured from seismology suggests that the mantle convection today is strongly time-dependent. The transition to hard-turbulence takes place at much lower Nusselt numbers for non-Newtonian than for Newtonian rheology. For the mantle this would have important ramifications. Non-Newtonian plumes behave quite differently from Newtonian ones in that large curvatures are developed in their trajectories in the hard turbulent regime. Mantle convection with phase transitions Lends to become wore layered with increasing Rayleigh numbers. The style of mantle convection might have changed from a layered to a more whole mantle type of flow with time. Catastrophic overturns associated with strong gravitational instabilities in the transition zone could be responsible for superplume events. C1 CERFACS,TOULOUSE,FRANCE. UNIV MINNESOTA,ARMY HIGH PERFORMANCE COMP & RES CTR,MINNEAPOLIS,MN 55455. UNIV UTRECHT,INST EARTH SCI,DEPT THEORET GEOPHYS,UTRECHT,NETHERLANDS. RP YUEN, DA (reprint author), UNIV MINNESOTA,MINNESOTA SUPERCOMP INST,DEPT GEOL & GEOPHYS,MINNEAPOLIS,MN 55415, USA. NR 107 TC 48 Z9 48 U1 0 U2 1 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 SN 0148-0227 J9 J GEOPHYS RES-PLANET JI J. Geophys. Res.-Planets PD MAR 25 PY 1993 VL 98 IS E3 BP 5355 EP 5373 DI 10.1029/92JE02725 PG 19 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA KW894 UT WOS:A1993KW89400009 ER PT J AU BORNEMANN, M JOHNSON, AC AF BORNEMANN, M JOHNSON, AC TI ENDOCRINE EFFECTS OF HIV-INFECTION SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Letter RP BORNEMANN, M (reprint author), TRIPLER ARMY MED CTR,HONOLULU,HI 96859, USA. NR 1 TC 3 Z9 3 U1 0 U2 0 PU MASS MEDICAL SOC PI BOSTON PA 10 SHATTUCK, BOSTON, MA 02115 SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD MAR 25 PY 1993 VL 328 IS 12 BP 890 EP 890 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA KT814 UT WOS:A1993KT81400030 PM 8441445 ER PT J AU HONIG, PK WORTHAM, DC ZAMANI, K CONNER, DP MULLIN, JC CANTILENA, LR AF HONIG, PK WORTHAM, DC ZAMANI, K CONNER, DP MULLIN, JC CANTILENA, LR TI TERFENADINE-KETOCONAZOLE INTERACTION - PHARMACOKINETIC AND ELECTROCARDIOGRAPHIC CONSEQUENCES SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Article ID ERYTHROMYCIN; METABOLITE AB Objective.-To examine prospectively the effects of ketoconazole on the pharmacokinetics and electrocardiographic repolarization pharmacodynamics (corrected QT intervals) of terfenadine in men and women. Design.-Prospective cohort study with each subject serving as his or her own control. Setting.-Outpatient cardiology clinic and inpatient telemetry unit for monitoring period. Participants.-Six healthy volunteers (four men and two women, aged 24 to 35 years) not taking any prescription or over-the-counter medications. Intervention.-After achieving a steady state while taking terfenadine (60 mg every 12 hours for 7 days), daily concomitant oral ketoconazole (200 mg every 12 hours) was added to the subjects' regimen. Pharmacokinetic profiles were obtained while subjects were taking terfenadine alone and after the addition of ketoconazole. Electrocardiograms were obtained at baseline, after 1 week of taking terfenadine alone, and at the time of the second pharmacokinetic profile after the addition of ketoconazole to the regimen. Main Outcome Measures.-Terfenadine and its acid metabolite serum concentrations and corrected QT intervals. Results.-All subjects had detectable levels of unmetabolized terfenadine after the addition of ketoconazole, which was associated with QT prolongation. Only two of the six subjects could complete the entire course of ketoconazole coadministration. Four subjects received a shortened duration of ketoconazole therapy because of significant electrocardiographic repolarization abnormalities. There was a significant change in the area under the curve of the acid metabolite of terfenadine after the addition of ketoconazole administration. Conclusions.-Ketoconazole alters the metabolism of terfenadine in normal men and women and results in the accumulation of unmetabolized parent drug, which is associated with significant prolongation of the corrected QT interval. This drug combination should be avoided. C1 UNIFORMED SERV UNIV HLTH SCI,DEPT PHARMACOL,DIV CLIN PHARMACOL,4301 JONES BRIDGE RD,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,DIV CARDIOL,WASHINGTON,DC 20307. US FDA,ROCKVILLE,MD 20857. RI Zamani, Kaveh/A-9182-2011 NR 28 TC 571 Z9 580 U1 1 U2 5 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD MAR 24 PY 1993 VL 269 IS 12 BP 1513 EP 1518 DI 10.1001/jama.269.12.1513 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA KR803 UT WOS:A1993KR80300023 PM 8445813 ER PT J AU ERDOGAN, MU KIM, KW STROSCIO, MA AF ERDOGAN, MU KIM, KW STROSCIO, MA TI EFFECTS OF BAND MIXING ON HOLE TUNNELING TIMES IN GAAS/ALAS DOUBLE-BARRIER HETEROSTRUCTURES SO APPLIED PHYSICS LETTERS LA English DT Article ID QUANTUM WELLS; FREQUENCY LIMIT; OSCILLATORS AB The tunneling time of holes in GaAs/AlAs double-barrier heterostructures is calculated within the envelope function approximation, including band-mixing effects. The phase delay time is obtained from the energy derivative of the total phase shift of the wave function upon tunneling. The results show clearly that mixing plays a very important role in hole tunneling. In particular, our study suggests that the conventional effective mass models (without band mixing) can significantly overestimate the heavy hole tunneling time and thus are not suitable for estimation of the hole tunneling time. It is also demonstrated that the effect of band mixing on hole tunneling times becomes more important for thicker barriers. C1 USA,RES OFF,RES TRIANGLE PK,NC 27709. RP ERDOGAN, MU (reprint author), N CAROLINA STATE UNIV,DEPT ELECT & COMP ENGN,RALEIGH,NC 27695, USA. NR 19 TC 9 Z9 9 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD MAR 22 PY 1993 VL 62 IS 12 BP 1423 EP 1425 PG 3 WC Physics, Applied SC Physics GA KT419 UT WOS:A1993KT41900039 ER PT J AU RICKMAN, WJ MONICAL, C WAXDAL, MJ AF RICKMAN, WJ MONICAL, C WAXDAL, MJ TI IMPROVED PRECISION IN THE ENUMERATION OF ABSOLUTE NUMBERS OF LYMPHOCYTE PHENOTYPES WITH LONG-TERM MONTHLY PROFICIENCY TESTING SO ANNALS OF THE NEW YORK ACADEMY OF SCIENCES LA English DT Article ID PROGRAM C1 FAST SYST INC,GAITHERSBURG,MD 20877. RP RICKMAN, WJ (reprint author), WALTER REED ARMY INST RES,DEPT DIAGNOST RETROVIROL,WASHINGTON,DC 20307, USA. NR 7 TC 20 Z9 20 U1 0 U2 0 PU NEW YORK ACAD SCIENCES PI NEW YORK PA 2 E 63RD ST, NEW YORK, NY 10021 SN 0077-8923 J9 ANN NY ACAD SCI JI Ann. N.Y. Acad. Sci. PD MAR 20 PY 1993 VL 677 BP 53 EP 58 DI 10.1111/j.1749-6632.1993.tb38764.x PG 6 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA KX225 UT WOS:A1993KX22500008 PM 8494246 ER PT J AU COLBECK, SC AF COLBECK, SC TI SHIFTS IN ICE-SHEET TEMPERATURES SO JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES LA English DT Article ID SNOW AB The entire temperature gradient in an ice sheet can be shifted by processes that occur just below the surface. Energy absorbed close to the surface flows back to the surface which steepens the average temperature gradient near the surface and shifts the entire temperature profile to higher values. For a constant density this shift equals A/alpha2k, where A is the average annual strength of the energy source, a is its exponential decay rate with depth, and k is the thermal conductivity. Various sources are considered as are density profiles and transients. While some sources can increase the 10-m temperature in ice sheets, air currents flowing through show can either heat or cool the snow at depth and can dominate all other processes. The relative contributions of the different mechanisms must be evaluated for any particular site. RP COLBECK, SC (reprint author), COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 23 TC 1 Z9 1 U1 2 U2 2 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 SN 0148-0227 J9 J GEOPHYS RES-ATMOS JI J. Geophys. Res.-Atmos. PD MAR 20 PY 1993 VL 98 IS D3 BP 5115 EP 5120 DI 10.1029/92JD02513 PG 6 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA KU069 UT WOS:A1993KU06900020 ER PT J AU SAUER, DR SCHNELLER, SW GABRIELSEN, B AF SAUER, DR SCHNELLER, SW GABRIELSEN, B TI 4-HOMOPYRAZOFURIN AND AN ACYCLIC ANALOG SO CARBOHYDRATE RESEARCH LA English DT Article ID 4-DEOXYPYRAZOFURIN; NUCLEOSIDE; DERIVATIVES AB The synthesis of 4-hydroxymethyl-3(5)-(beta-D-ribofuranosyl)pyrazole-5(3)-carboxamide (2, 4-homopyrazofurin) is described via a pathway that commences with the dipolar cycloaddition reaction of 2,5-anhydro-3,4,6-tri-O-benzyl-1-deoxy-1-diazo-D-allitol (4) and methyl 4-benzyloxy-2-butynoate (5). Preparation of 3(5)-[(2-hydrox,-ethoxy)methyl]-4-(hydroxymethyl)pyrazole-5(3)-carboxamide (3) as a derivative of 2 possessing the truncated acyclic side chain of acyclovir has been accomplished in a similar manner beginning with the reaction of 5 with 1-diazo-2-[(2-benzyloxy)ethoxy]ethane (13). Neither compound 2 nor 3 showed any in vitro antiviral activity against human immunodeficiency virus (HIV-1), sandfly fever, Punta Toro, Japanese encephalitis, yellow fever, Venezuelan equine encephalomyelitis, and vaccinia viruses. Both compounds were also nontoxic. These results suggest that direct bonding of the hydroxyl group to the pyrazole ring is important for pyrazofurin based agents to demonstrate biological activity. C1 UNIV S FLORIDA,DEPT CHEM,TAMPA,FL 33620. USA,MED RES INST INFECT DIS,FREDERICK,MD 21701. NR 15 TC 9 Z9 9 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0008-6215 J9 CARBOHYD RES JI Carbohydr. Res. PD MAR 17 PY 1993 VL 241 BP 71 EP 79 DI 10.1016/0008-6215(93)80096-W PG 9 WC Biochemistry & Molecular Biology; Chemistry, Applied; Chemistry, Organic SC Biochemistry & Molecular Biology; Chemistry GA KT855 UT WOS:A1993KT85500008 ER PT J AU MAHADIK, SP WAKADE, CG SCHEFFER, R CORRENTI, E BORISON, RL MUKHERJEE, S AF MAHADIK, SP WAKADE, CG SCHEFFER, R CORRENTI, E BORISON, RL MUKHERJEE, S TI ABNORMAL GROWTH OF SKIN FIBROBLASTS FROM DRUG-NAIVE PSYCHOTIC-PATIENTS SO BIOLOGICAL PSYCHIATRY LA English DT Meeting Abstract C1 MED COLL GEORGIA,DEPT PSYCHIAT,AUGUSTA,GA 30912. DD EISENHOWER ARMY MED CTR,FT GORDON,GA. NR 0 TC 6 Z9 6 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0006-3223 J9 BIOL PSYCHIAT JI Biol. Psychiatry PD MAR 15 PY 1993 VL 33 IS 6A SU S BP A69 EP A69 PG 1 WC Neurosciences; Psychiatry SC Neurosciences & Neurology; Psychiatry GA LA417 UT WOS:A1993LA41700118 ER PT J AU SCHUSCHEREBA, ST BOWMAN, PD LUND, DJ VARGAS, JA AF SCHUSCHEREBA, ST BOWMAN, PD LUND, DJ VARGAS, JA TI ACCELERATED HEALING OF LASER-INJURED MONKEY RETINA BY BASIC FIBROBLAST GROWTH-FACTOR (BFGF) SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 USA,MED RES DETACHMENT,SAN ANTONIO,TX 78235. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1993 VL 34 IS 4 BP 962 EP 962 PG 1 WC Ophthalmology SC Ophthalmology GA KT893 UT WOS:A1993KT89301283 ER PT J AU CAVALLARO, BE HOLLIFIELD, RD WARD, TP WERTZ, FD AF CAVALLARO, BE HOLLIFIELD, RD WARD, TP WERTZ, FD TI THE MEDICAL IMPLICATIONS OF INTRAOCULAR BALLISTIC AND LASER PROTECTIVE SPECTACLE (BLPS) FRAGMENTS SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,SERV OPHTHALMOL,OCULAR TRAUMA RES UNIT,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1993 VL 34 IS 4 BP 1115 EP 1115 PG 1 WC Ophthalmology SC Ophthalmology GA KT893 UT WOS:A1993KT89302029 ER PT J AU PEELE, KA ROSENBERG, ML AF PEELE, KA ROSENBERG, ML TI THE ROLE OF PERIPHERAL VISUAL-FIELDS IN IDIOPATHIC INTRACRANIAL HYPERTENSION SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1993 VL 34 IS 4 BP 1122 EP 1122 PG 1 WC Ophthalmology SC Ophthalmology GA KT893 UT WOS:A1993KT89302065 ER PT J AU KLYMENKO, V VERONA, RW BEASLEY, HH MARTIN, JS AF KLYMENKO, V VERONA, RW BEASLEY, HH MARTIN, JS TI BINOCULAR VIEWING MODE AFFECTS SPATIOTEMPORAL CONTRAST THRESHOLD SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 USA,AEROMED RES LAB,UES INC,FT RUCKER,AL 36362. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1993 VL 34 IS 4 BP 1190 EP 1190 PG 1 WC Ophthalmology SC Ophthalmology GA KT893 UT WOS:A1993KT89302395 ER PT J AU PUCKETT, TR MILLER, MB PEELE, KA KRAMER, KK AF PUCKETT, TR MILLER, MB PEELE, KA KRAMER, KK TI INTRAOCULAR IRRIGATING SOLUTIONS - A CLINICAL-TRIAL OF BSS PLUS AND DEXTROSE BICARBONATE LACTATED RINGERS SOLUTION SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1993 VL 34 IS 4 BP 1224 EP 1224 PG 1 WC Ophthalmology SC Ophthalmology GA KT893 UT WOS:A1993KT89302555 ER PT J AU KOTULAK, JC MORSE, SE AF KOTULAK, JC MORSE, SE TI USER FOCUS ADJUSTMENTS AND ACCOMMODATION IN INSTRUMENT MYOPIA SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 USA,AEROMED RES LAB,FT RUCKER,AL 36360. NR 0 TC 1 Z9 1 U1 0 U2 3 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1993 VL 34 IS 4 BP 1312 EP 1312 PG 1 WC Ophthalmology SC Ophthalmology GA KT893 UT WOS:A1993KT89302998 ER PT J AU RABIN, J WILEY, RW VERONA, RW AF RABIN, J WILEY, RW VERONA, RW TI VISUAL PERFORMANCE THROUGH NIGHT-VISION DEVICES SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 USA,AEROMED RES LAB,FT RUCKER,AL 36362. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1993 VL 34 IS 4 BP 1418 EP 1418 PG 1 WC Ophthalmology SC Ophthalmology GA KT893 UT WOS:A1993KT89303535 ER PT J AU ZHANG, Q DAY, PN TRUHLAR, DG AF ZHANG, Q DAY, PN TRUHLAR, DG TI THE ACCURACY OF 2ND-ORDER PERTURBATION-THEORY FOR MULTIPLY EXCITED VIBRATIONAL-ENERGY LEVELS AND PARTITION-FUNCTIONS FOR A SYMMETRICAL TOP MOLECULAR ION SO JOURNAL OF CHEMICAL PHYSICS LA English DT Article ID ROVIBRATIONAL STATES; POLYATOMIC-MOLECULES; ROTATIONAL ANALYSIS; H-3+; CONSTANTS; INTENSITIES; ISOTOPOMERS; SPECTRUM; SURFACES; H-3(+) AB The vibrational energy levels and partition functions of the nonrotating H-3+ molecular ion have been calculated by using second order perturbation theory, including constant, linear, and quadratic terms in the vibrational quantum numbers. Energy levels have been assigned to A1', A2', and E' symmetry species up to 29 244 cm-1, and perturbation theory energy levels have been compared with the results of accurate quantum calculations. The root-mean-square error in 141 energy levels is 4.0 cm-1 as compared to 11.7 cm-1 in the harmonic approximation. Furthermore, perturbation-theory partition functions have errors of 7.4% or less over the factor-of-20 temperature range from 200 to 4000 K. The effect of the constant term in perturbation theory is also discussed; it improves the vibrational partition functions by approximately 4% at 200 K. C1 UNIV MINNESOTA, ARMY HIGH PERFORMANCE COMP RES CTR, MINNEAPOLIS, MN 55455 USA. RP ZHANG, Q (reprint author), UNIV MINNESOTA, DEPT CHEM, INST SUPERCOMP, MINNEAPOLIS, MN 55455 USA. RI Truhlar, Donald/G-7076-2015 OI Truhlar, Donald/0000-0002-7742-7294 NR 59 TC 34 Z9 34 U1 1 U2 5 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-9606 J9 J CHEM PHYS JI J. Chem. Phys. PD MAR 15 PY 1993 VL 98 IS 6 BP 4948 EP 4958 DI 10.1063/1.464950 PG 11 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA KU222 UT WOS:A1993KU22200066 ER PT J AU FINBLOOM, DS LARNER, AC NAKAGAWA, Y HOOVER, DL AF FINBLOOM, DS LARNER, AC NAKAGAWA, Y HOOVER, DL TI CULTURE OF HUMAN MONOCYTES WITH GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR RESULTS IN ENHANCEMENT OF IFN-GAMMA RECEPTORS BUT SUPPRESSION OF IFN-GAMMA-INDUCED EXPRESSION OF THE GENE-IP-10 SO JOURNAL OF IMMUNOLOGY LA English DT Article ID CHRONIC INFLAMMATORY ARTHRITIS; RECOMBINANT INTERFERON-GAMMA; GENE-EXPRESSION; CELL-LINES; ANTIBODIES; BINDING; IDENTIFICATION; ACTIVATION; INDUCTION; CYTOKINES AB The initiation and promulgation of chronic inflammation are controlled in part by the various proinflammatory and anti-inflammatory cytokines present at the site of injury. IFN-gamma and granulocyte-macrophage CSF (GM-CSF) are two cytokines that can contribute to the inflammatory state and possess both pro- and anti-inflammatory properties. However, the characterization of the interaction between GM-CSF-cultured monocytes and IFN-gamma is poorly documented. In this report we show that culture of human peripheral blood monocytes for up to 6 days in the presence of GM-CSF results in an eightfold increase in the level of IFN-gammaR expression, as determined by radioligand binding. The IFN-gammaR on these cells maintains a specificity typical of that observed in fresh monocytes. Only IFN-gamma, not IFN-alpha or -beta, blocks the binding of IFN-gamma to its receptor, and anti-IFN-gammaR antibodies block at least 80% of binding of IFN-gamma to these cultured cells. However, in spite of increased receptor expression, GM-CSF-cultured monocytes have a diminished response to IFN-gamma as measured by the induction of the gene for IP-10 (a member of the platelet factor-4/IL-8 family). On the other hand, IFN-gamma-induced activation of the DNA-binding protein FcRFgamma is maintained in GM-CSF-cultured monocytes. Therefore, suppression of IFN-gamma-mediated IP-10 induction is not the result of a global abrogation of signal transduction across the IFN-gammaR but a more selective inhibition that appears to occur downstream of the receptor. C1 WALTER REED ARMY INST RES,DEPT BACTERIAL DIS,WASHINGTON,DC 20307. RP FINBLOOM, DS (reprint author), US FDA,CTR BIOL EVALUAT & RES,DIV CYTOKINE BIOL,8800 ROCKVILLE PIKE,BETHESDA,MD 20892, USA. NR 39 TC 32 Z9 33 U1 0 U2 0 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD MAR 15 PY 1993 VL 150 IS 6 BP 2383 EP 2390 PG 8 WC Immunology SC Immunology GA KR934 UT WOS:A1993KR93400031 PM 8450219 ER PT J AU KATTAMIS, TZ BHANSALI, KJ LEVY, M ADLER, R RAMALINGAM, S AF KATTAMIS, TZ BHANSALI, KJ LEVY, M ADLER, R RAMALINGAM, S TI EVALUATION OF THE STRENGTH AND ADHERENCE OF SOFT COBALT-BASE AND HARD TIN COATINGS ON 4340 LOW-ALLOY STEEL SO MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES MICROSTRUCTURE AND PROCESSING LA English DT Article ID ADHESION AB Soft T-800 and SF-6 cobalt-base alloy coatings and hard TiN coatings were deposited by cathodic arc plasma PVD on 4340 and chromium-plated 4340 low alloy steel specimens. The cohesive load and adherence of the coatings to the substrate were evaluated with an automated scratch testing apparatus and their abrasive wear resistance was measured with a pin-on-disk tribometer. The soft coatings adhere strongly to 4340. During testing transverse cracks initiate within the coating at the cohesive load and propagate into the substrate without delamination. These coatings also adhere strongly to chromium-preplated 4340. During testing pre-existing cracks within the chromium layer propagate across the coating and the substrate at a lower load and spacing is smaller than in nonplated specimens. Soft coatings processed at a lower pressure are stronger. Hard TiN coatings on 4340 or chromium-preplated 4340 exhibit approximately the same cohesive and critical loads. The wear resistance of coatings on 4340 specimens is higher than on chromium-preplated 4340 specimens. For the specimens and experimental conditions used herein the nitride coatings exhibit a higher wear resistance than T-800 coatings which, in turn, are more wear resistant than SF-6 coatings. C1 USA,AVSCOM,AMSAV-EMF,ST LOUIS,MO 63120. USA,MAT TECHNOL LAB,WATERTOWN,MA 02172. UNIV MINNESOTA,MINNEAPOLIS,MN 55455. RP KATTAMIS, TZ (reprint author), UNIV CONNECTICUT,STORRS,CT 06269, USA. NR 14 TC 7 Z9 7 U1 1 U2 1 PU ELSEVIER SCIENCE SA LAUSANNE PI LAUSANNE 1 PA PO BOX 564, 1001 LAUSANNE 1, SWITZERLAND SN 0921-5093 J9 MAT SCI ENG A-STRUCT JI Mater. Sci. Eng. A-Struct. Mater. Prop. Microstruct. Process. PD MAR 15 PY 1993 VL 161 IS 1 BP 105 EP 117 DI 10.1016/0921-5093(93)90481-S PG 13 WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Science & Technology - Other Topics; Materials Science; Metallurgy & Metallurgical Engineering GA KT461 UT WOS:A1993KT46100013 ER PT J AU DAVIS, NL GREENWALD, GF VALENSKI, ML SMITH, JF BARTZ, C LAEGREID, W JOHNSTON, RE AF DAVIS, NL GREENWALD, GF VALENSKI, ML SMITH, JF BARTZ, C LAEGREID, W JOHNSTON, RE TI A GENETICALLY ENGINEERED LIVE VIRUS-VACCINE FOR VENEZUELAN EQUINE ENCEPHALITIS SO JOURNAL OF CELLULAR BIOCHEMISTRY LA English DT Meeting Abstract C1 UNIV N CAROLINA,DEPT MICROBIOL & IMMUNOL,CHAPEL HILL,NC 27599. USA,INFECT DIS RES INST,FT DETRICK,MD 21701. PLUM ISL ANIM DIS CTR,GREENPORT,NY 11944. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0730-2312 J9 J CELL BIOCHEM JI J. Cell. Biochem. PD MAR 13 PY 1993 SU 17D BP 79 EP 79 PG 1 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA KV880 UT WOS:A1993KV88000271 ER PT J AU SITZ, KV VANCOTT, TC DARDEN, JM REDFIELD, RR BIRX, DL AF SITZ, KV VANCOTT, TC DARDEN, JM REDFIELD, RR BIRX, DL TI NAIVE AND MEMORY T-LYMPHOCYTES IN THE CONTEXT OF A PHASE-I GP 160 VACCINE THERAPY TRIAL SO JOURNAL OF CELLULAR BIOCHEMISTRY LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,DEPT RETROVIRAL RES,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0730-2312 J9 J CELL BIOCHEM JI J. Cell. Biochem. PD MAR 13 PY 1993 SU 17D BP 85 EP 85 PG 1 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA KV880 UT WOS:A1993KV88000295 ER PT J AU DOWLING, J AF DOWLING, J TI TOTALLY PHASED SO NEW SCIENTIST LA English DT Letter RP DOWLING, J (reprint author), USA,MISSILE RES & DEV COMMAND,REDSTONE ARSENAL,AL 35809, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU NEW SCIENTIST PUBL EXPEDITING INC PI ELMONT PA 200 MEACHAM AVE, ELMONT, NY 11003 SN 0262-4079 J9 NEW SCI JI New Sci. PD MAR 13 PY 1993 VL 137 IS 1864 BP 55 EP 55 PG 1 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA KT021 UT WOS:A1993KT02100052 ER PT J AU HELMBOLD, RL AF HELMBOLD, RL TI OSIPOV - THE RUSSIAN LANCHESTER SO EUROPEAN JOURNAL OF OPERATIONAL RESEARCH LA English DT Article DE HISTORY; MILITARY; PRACTICE; EMPIRICAL STATISTICS; DIFFERENTIAL EQUATIONS; LANCHESTER EQUATION; OSIPOV AB In 1915, practically contemporaneously with lanchester, M. Osipov published a remarkable series of articles in the Tzarist Russian journal Military Collection. These articles contain a complete analysis of what in the West has conventionally been called Lanchester's square law. A new translation of Osipov's work has recently been completed, which will make it easier for Western military analysts to appreciate its merits. RP HELMBOLD, RL (reprint author), USA,CONCEPTS ANAL AGCY,8120 WOODMONT AVE,BETHESDA,MD 20814, USA. NR 34 TC 7 Z9 8 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0377-2217 J9 EUR J OPER RES JI Eur. J. Oper. Res. PD MAR 12 PY 1993 VL 65 IS 2 BP 278 EP 288 DI 10.1016/0377-2217(93)90341-J PG 11 WC Management; Operations Research & Management Science SC Business & Economics; Operations Research & Management Science GA KR327 UT WOS:A1993KR32700013 ER PT J AU DOWLING, JP BOWDEN, CM AF DOWLING, JP BOWDEN, CM TI NEAR DIPOLE-DIPOLE EFFECTS IN LASING WITHOUT INVERSION - AN ENHANCEMENT OF GAIN AND ABSORPTIONLESS INDEX OF REFRACTION SO PHYSICAL REVIEW LETTERS LA English DT Article ID ELECTROMAGNETICALLY INDUCED TRANSPARENCY; INTRINSIC OPTICAL BISTABILITY; FINITE MOLECULAR FLUID; POPULATION-INVERSION; RADIATION AMPLIFICATION; QUANTUM COHERENCE; LOCAL-FIELD; SCATTERING; RESONANCES; LIGHT AB We include the effect of density-dependent near dipole-dipole interactions in order to generalize the theory of a simple three-level system that exhibits lasing without inversion and an enhanced index of refraction at zero absorption. For certain values of atomic density, our generalized theory predicts a novel enhancement of inversionless gain and absorptionless index by more than 2 orders of magnitude. RP USA, MISSILE COMMAND,CTR RES DEV & ENGN,ST,WS,RD,AMSMI, WEAP SCI DIRECTORATE, REDSTONE ARSENAL, AL 35898 USA. RI DOWLING, JONATHAN/L-2749-2013 NR 37 TC 104 Z9 104 U1 0 U2 3 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0031-9007 EI 1079-7114 J9 PHYS REV LETT JI Phys. Rev. Lett. PD MAR 8 PY 1993 VL 70 IS 10 BP 1421 EP 1424 DI 10.1103/PhysRevLett.70.1421 PG 4 WC Physics, Multidisciplinary SC Physics GA KQ414 UT WOS:A1993KQ41400017 ER PT J AU MALEVSKY, AV YUEN, DA AF MALEVSKY, AV YUEN, DA TI PLUME STRUCTURES IN THE HARD-TURBULENT REGIME OF 3-DIMENSIONAL INFINITE PRANDTL NUMBER CONVECTION SO GEOPHYSICAL RESEARCH LETTERS LA English DT Article ID RAYLEIGH-BENARD CONVECTION; THERMAL-CONVECTION; TRANSITION AB Numerical simulations of three-dimensional infinite Prandtl number thermal convection with Rayleigh number (Ra) up to 10(8) are reported. Convection with Ra higher than 10(7) is characterized by the appearance of disconnected thermal plumes. The smaller plumes are detached by the currents produced by the larger plumes. The low wavenumber portion of a thermal power spectrum near the boundary layer becomes flat at high Ra, while the spectrum measured in the interior shows a positive slope for low wavenumbers. Differences are found in the thermal spectra between 2D and 3D models. C1 USA,HIGH PERFORMANCE COMP RES CTR,MINNEAPOLIS,MN. RP MALEVSKY, AV (reprint author), UNIV MINNESOTA,MINNESOTA SUPERCOMP INST,1200 WASHINGTON AVE S,MINNEAPOLIS,MN 55415, USA. NR 13 TC 28 Z9 28 U1 0 U2 0 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 SN 0094-8276 J9 GEOPHYS RES LETT JI Geophys. Res. Lett. PD MAR 5 PY 1993 VL 20 IS 5 BP 383 EP 386 DI 10.1029/93GL00293 PG 4 WC Geosciences, Multidisciplinary SC Geology GA KR866 UT WOS:A1993KR86600013 ER PT J AU GREGORY, DA KIRSCH, JC TANONE, A YIN, S ANDRES, P YU, FTS TAM, EC AF GREGORY, DA KIRSCH, JC TANONE, A YIN, S ANDRES, P YU, FTS TAM, EC TI PHASE MODULATION IN A LIQUID-CRYSTAL TV BASED JOINT TRANSFORM CORRELATOR SO MICROWAVE AND OPTICAL TECHNOLOGY LETTERS LA English DT Article DE LCTV; PHASE MODULATOR; JOINT TRANSFORM CORRELATOR AB A phase-encoded object has been modeled as the input to a joint transform correlator. The joint transform power spectrum is modeled as a binary phase object to calculate the correlation output. The results have been experimentally verified using a liquid-crystal television operating in the phase modulation mode. RP GREGORY, DA (reprint author), USA,MISSILE COMMAND,REDSTONE ARSENAL,AL 35898, USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU JOHN WILEY & SONS INC PI NEW YORK PA 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0895-2477 J9 MICROW OPT TECHN LET JI Microw. Opt. Technol. Lett. PD MAR 5 PY 1993 VL 6 IS 3 BP 211 EP 214 DI 10.1002/mop.4650060318 PG 4 WC Engineering, Electrical & Electronic; Optics SC Engineering; Optics GA KL796 UT WOS:A1993KL79600017 ER PT J AU MERKEL, KG BRIGHT, VM SCHAUER, SN HUANG, CI ROBINSON, GD AF MERKEL, KG BRIGHT, VM SCHAUER, SN HUANG, CI ROBINSON, GD TI GEMOW REFRACTORY OHMIC CONTACTS TO N-TYPE GAAS WITH IN0.5GA0.5AS CAP LAYER SO ELECTRONICS LETTERS LA English DT Article DE SEMICONDUCTOR DEVIDES AND MATERIALS; INDIUM COMPOUNDS; OHMIC CONTACTS ID METAL AB GeMoW is presented as a refractory ohmic contact to n-type GaAs with an In0.5Ga0.5As cap layer. The contact exhibits ohmic behaviour over a wide annealing temperature range from 300 to 700-degrees-C. A minimum contact resistance of 0-176 OMEGA mm was obtained following furnace annealing at 500-degrees-C. C1 USA,ELECTR TECHNOL & DEV LAB,FT MONMOUTH,NJ 07703. WRIGHT LAB,SOLID STATE ELECTR DIRECTORATE,WRIGHT PATTERSON AFB,OH 45433. RP MERKEL, KG (reprint author), USAF,INST TECHNOL,DEPT ELECT & COMP ENGN,WRIGHT PATTERSON AFB,OH 45433, USA. NR 11 TC 2 Z9 2 U1 0 U2 0 PU IEE-INST ELEC ENG PI HERTFORD PA MICHAEL FARADAY HOUSE SIX HILLS WAY STEVENAGE, HERTFORD, ENGLAND SG1 2AY SN 0013-5194 J9 ELECTRON LETT JI Electron. Lett. PD MAR 4 PY 1993 VL 29 IS 5 BP 480 EP 481 DI 10.1049/el:19930321 PG 2 WC Engineering, Electrical & Electronic SC Engineering GA LB767 UT WOS:A1993LB76700038 ER PT J AU HASTORF, CA JOHANNESSEN, S AF HASTORF, CA JOHANNESSEN, S TI PRE-HISPANIC POLITICAL-CHANGE AND THE ROLE OF MAIZE IN THE CENTRAL ANDES OF PERU SO AMERICAN ANTHROPOLOGIST LA English DT Article ID CONSUMPTION AB While archeologists have the capacity to track changing food use in the archeological record, they have not tended to use food systems in the study of social and political change. To do so, an awareness must be gained of the meanings of foods, which then can illuminate the strategic use of a particular food in the creation of relationships of dependence and prestige. Archeological evidence from the central Andes of Peru indicates that the role of maize changed between A.D. 500 and 1500, shifting from a culinary item, simply prepared by boiling, to a more complex symbolic food, transformed through grinding and brewing into beer, with elaborated political meanings. This change in maize processing and consumption occurred at a time of heightened political and social tensions. We propose that the shift in maize use reflected and participated in new political dynamics, demonstrating how foodways can inform archeologists about past social and political systems. C1 USA,CORPS ENGINEERS,ST PAUL,MN 55101. RP HASTORF, CA (reprint author), UNIV MINNESOTA,DEPT ANTHROPOL,MINNEAPOLIS,MN 55455, USA. NR 75 TC 84 Z9 85 U1 1 U2 5 PU AMER ANTHROPOLOGICAL ASSOC PI ARLINGTON PA 4350 NORTH FAIRFAX DRIVE SUITE 640, ARLINGTON, VA 22203 SN 0002-7294 J9 AM ANTHROPOL JI Am. Anthropol. PD MAR PY 1993 VL 95 IS 1 BP 115 EP 138 DI 10.1525/aa.1993.95.1.02a00060 PG 24 WC Anthropology SC Anthropology GA KU108 UT WOS:A1993KU10800006 ER PT J AU WORTHAM, DC GORMAN, PD HULL, RW VERNALIS, MN GAITHER, NS AF WORTHAM, DC GORMAN, PD HULL, RW VERNALIS, MN GAITHER, NS TI UNRUPTURED SINUS OF VALSALVA ANEURYSM PRESENTING WITH EMBOLIZATION SO AMERICAN HEART JOURNAL LA English DT Note RP WORTHAM, DC (reprint author), WALTER REED ARMY MED CTR,CARDIOL SERV,WASHINGTON,DC 20307, USA. NR 5 TC 11 Z9 11 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0002-8703 J9 AM HEART J JI Am. Heart J. PD MAR PY 1993 VL 125 IS 3 BP 896 EP 898 DI 10.1016/0002-8703(93)90191-B PG 3 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA KQ122 UT WOS:A1993KQ12200040 PM 8438725 ER PT J AU STRATTON, RF YOUNG, RS HEIMAN, HS CARTER, JM AF STRATTON, RF YOUNG, RS HEIMAN, HS CARTER, JM TI FRYNS SYNDROME SO AMERICAN JOURNAL OF MEDICAL GENETICS LA English DT Article DE DIAPHRAGM EVENTRATION; DUODENAL ATRESIA; CLEFT LIP; TETRALOGY OF FALLOT; CAMPTODACTYLY; TRACHEOMALACIA; BRONCHOMALACIA; FRYNS SYNDROME ID CONGENITAL DIAPHRAGMATIC-HERNIA; DISTAL DIGITAL HYPOPLASIA; ANOMALY MCA SYNDROME; CRANIOFACIAL DYSMORPHISM; LIMB DEFORMITIES; LETHAL SYNDROME; DEFECTS; DUPLICATION; FACE AB We report on a premature female infant with Fryns syndrome who had several less commonly reported anomalies. She had bilateral posterior eventration of the hemidiaphragms instead of the usual diaphragmatic defects with visceral herniation into the chest cavity. She also had a unilateral cleft lip, camptodactyly, duodenal atresia, tracheomalacia, bronchomalacia, and Tetralogy of Fallot. C1 BROOKE ARMY MED CTR,DEPT PEDIAT,FT SAM HOUSTON,TX 78234. RP STRATTON, RF (reprint author), S TEXAS GENET CTR,7922 EWING HALSELL,SUITE 410,SAN ANTONIO,TX 78229, USA. NR 19 TC 23 Z9 23 U1 0 U2 1 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0148-7299 J9 AM J MED GENET JI Am. J. Med. Genet. PD MAR 1 PY 1993 VL 45 IS 5 BP 562 EP 564 DI 10.1002/ajmg.1320450507 PG 3 WC Genetics & Heredity SC Genetics & Heredity GA KM616 UT WOS:A1993KM61600006 PM 8456824 ER PT J AU BENEDIKT, RA BROWN, DC WALKER, R GHAED, VN MITCHELL, M GEYER, CA AF BENEDIKT, RA BROWN, DC WALKER, R GHAED, VN MITCHELL, M GEYER, CA TI STURGE-WEBER SYNDROME - CRANIAL MR IMAGING WITH GD-DTPA SO AMERICAN JOURNAL OF NEURORADIOLOGY LA English DT Article DE PHAKOMATOSES; CONTRAST MEDIA, PARAMAGNETIC ID CT; DISEASE AB PURPOSE: To study the role of Gd-DTPA in cranial MR of patients with Sturge-Weber syndrome. METHODS AND MATERIALS: Seven patients with Sturge-Weber syndrome, ages 3 months to 36 years, were evaluated with unenhanced and contrast-enhanced (Gd-DTPA) MR imaging. Correlation was made to cranial CT in five patients. RESULTS: MR findings included (in decreasing frequency): pial angiomatosis, cerebral atrophy, decrease in cortical veins, enlargement of deep veins, enlargement of choroid plexus, and parenchymal calcification. Contrast MR imaging was essential in diagnosis in four cases in which cranial CT, unenhanced MR, or angiography was normal or demonstrated nonspecific abnormalities. Pial angiomatosis with adjacent cerebral atrophy were the only consistent radiographic abnormalities. CONCLUSION: In all patients, contrast MR demonstrated the radiographic spectrum of central nervous system abnormalities in Sturge-Weber syndrome to a greater degree than unenhanced MR or CT and may represent the method of diagnosis in these patients. Demonstration of the pial angioma on contrast MR should be considered the most important criterion for the radiographic diagnosis of Sturge-Weber syndrome. C1 WALTER REED ARMY MED CTR,DEPT RADIOL,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,DEPT NUCL MED & RADIOL,BETHESDA,MD 20814. ALBANY MED CTR HOSP,DEPT RADIOL,ALBANY,NY 12208. WALTER REED ARMY MED CTR,PEDIAT NEUROL SECT,WASHINGTON,DC 20307. NR 18 TC 46 Z9 48 U1 0 U2 0 PU AMER SOC NEURORADIOLOGY PI OAK BROOK PA 2210 MIDWEST RD, OAK BROOK, IL 60521 SN 0195-6108 J9 AM J NEURORADIOL JI Am. J. Neuroradiol. PD MAR-APR PY 1993 VL 14 IS 2 BP 409 EP 415 PG 7 WC Clinical Neurology; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging GA KR570 UT WOS:A1993KR57000025 PM 8456721 ER PT J AU SCHAUDIES, RP JOHNSON, JP AF SCHAUDIES, RP JOHNSON, JP TI INCREASED SOLUBLE EGF AFTER ISCHEMIA IS ACCOMPANIED BY A DECREASE IN MEMBRANE-ASSOCIATED PRECURSORS SO AMERICAN JOURNAL OF PHYSIOLOGY LA English DT Article DE IMMUNOREACTIVE EPIDERMAL GROWTH FACTOR; RENAL FAILURE; EPIDERMAL GROWTH FACTOR PRECURSORS ID EPIDERMAL GROWTH-FACTOR; ACUTE-RENAL-FAILURE; CHEMICAL CHARACTERIZATION; BIOLOGICAL PROPERTIES; KIDNEY MEMBRANES; RAT-KIDNEY; RECEPTOR; IDENTIFICATION; MOUSE; REGENERATION AB We have characterized the distribution of immunoreactive epidermal growth factor (irEGF) in control and ischemia-injured rat kidneys. Kidneys that had undergone ischemic injury contained levels of soluble irEGF that were six times those of uninjured kidneys. The predominant forms of soluble irEGF were native and des-Arg-epidermal growth factor (EGF), both of which are biologically active. Crude membrane fractions from whole kidneys were solubilized in Triton X-100 and tested for irEGF. Amounts of irEGF were slightly decreased in the ischemia-injured kidney membranes. However, when solubilized membrane fractions were digested with trypsin, which generates a single immunoreactive species which appears identical to native EGF, the amount of irEGF in control fractions increased 13-fold and the amount in injured fractions increased only 4-fold as measured by radioimmunoassay. To better characterize the membrane-associated irEGF, Triton X-100-solubilized membrane fractions from control animals were affinity purified and subjected to high-performance liquid molecular sieve chromatography. Three major peaks of material exhibited immunoreactivity to EGF antibodies, bound the EGF receptor, and stimulated [H-3]thymidine incorporation in growth-arrested fibroblasts. Trypsin digestion of the two high-molecular-mass peaks enhanced these activities. The third peak eluted with native EGF and showed no change in activity with trypsin addition. We propose that EGF is released from membrane-associated EGF precursors and can then act in an autocrine or paracrine fashion to promote cell growth after ischemia-induced acute renal failure. RP SCHAUDIES, RP (reprint author), WALTER REED ARMY INST RES,DEPT NEPHROL,WASHINGTON,DC 20307, USA. NR 35 TC 49 Z9 49 U1 0 U2 0 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0002-9513 J9 AM J PHYSIOL JI Am. J. Physiol. PD MAR PY 1993 VL 264 IS 3 BP F523 EP F531 PN 2 PG 9 WC Physiology SC Physiology GA KV271 UT WOS:A1993KV27100091 PM 8456964 ER PT J AU KANE, AG NEESE, PA SLATER, DO AF KANE, AG NEESE, PA SLATER, DO TI INFRARENAL ATHEROSCLEROTIC AORTIC WEB SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Letter RP KANE, AG (reprint author), BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234, USA. NR 4 TC 0 Z9 0 U1 0 U2 0 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR, SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 SN 0361-803X J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD MAR PY 1993 VL 160 IS 3 BP 665 EP 665 PG 1 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA KM935 UT WOS:A1993KM93500055 PM 8430584 ER PT J AU SHMUKLARSKY, MJ KLAYMAN, DL MILHOUS, WK KYLE, DE ROSSAN, RN AGER, AL TANG, DB HEIFFER, MH CANFIELD, CJ SCHUSTER, BG AF SHMUKLARSKY, MJ KLAYMAN, DL MILHOUS, WK KYLE, DE ROSSAN, RN AGER, AL TANG, DB HEIFFER, MH CANFIELD, CJ SCHUSTER, BG TI COMPARISON OF BETA-ARTEMETHER AND BETA-ARTEETHER AGAINST MALARIA PARASITES INVITRO AND INVIVO SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID ANTIMALARIAL DRUG; RESISTANCE; ARTEMISININ; RESURGENCE AB The antimalarial activity of beta-artemether and beta-arteether was compared in three test systems: in vitro against chloroquine-resistant and chloroquine-sensitive Plasmodium falciparum parasites, in mice infected with P. berghei, and in Aotus monkeys infected with chloroquine-resistant P. falciparum. In vitro, the mean 50% inhibitory concentration (IC50) for beta-artemether was 1.74 nM (range 1.34-1.81 nM), and this value for beta-arteether was 1.61 nM (range 1.57-1.92 nM). They were approximately 2.5-fold more potent than artemisinin, which had a mean IC50 of 4.11 nM (range 3.36-4.60 nM). In the mouse model, the 50% curative doses (CD50) of beta-artemether and beta-arteether had a mean value of 55 mg/kg (32-78 mg/kg). The 50% effective curative doses (ED50) in the Aotus monkey were 7.1 mg/kg (95% confidence interval [CI] = 3.7-13.5) for beta-artemether and 11.8 mg/kg (95% CI = 6.5-21.3) for beta-arteether. Overall, the activities of the two drugs were comparable. C1 WALTER REED ARMY INST RES,DIV BIOMETR,WASHINGTON,DC 20307. GORGAS MEM LAB,PANAMA CITY,PANAMA. UNIV MIAMI,SCH MED,CTR TROP PARASIT DIS,MIAMI,FL 33152. PHARMACEUT SYST INC,GAITHERSBURG,MD. RP SHMUKLARSKY, MJ (reprint author), WALTER REED ARMY INST RES,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307, USA. NR 22 TC 38 Z9 38 U1 1 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD MAR PY 1993 VL 48 IS 3 BP 377 EP 384 PG 8 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA KX849 UT WOS:A1993KX84900012 PM 8470775 ER PT J AU MCKEE, KT ORO, JGB KUEHNE, AI SPISSO, JA MAHLANDT, BG AF MCKEE, KT ORO, JGB KUEHNE, AI SPISSO, JA MAHLANDT, BG TI SAFETY AND IMMUNOGENICITY OF A LIVE-ATTENUATED JUNIN (ARGENTINE HEMORRHAGIC-FEVER) VACCINE IN RHESUS MACAQUES SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID VIRUS-STRAINS; GUINEA-PIGS; INFECTION; RODENTS; MICE AB The safety and immunogenicity of Candid #1, a live-attenuated Junin virus vaccine, were evaluated in rhesus macaques. Candid #1 was inoculated subcutaneously in graded doses ranging from 16 to 127,200 plaque-forming units (PFU) into four groups of five animals each; four controls received saline. There was no significant effect of the immunization on any physical, hematologic, or biochemical parameter measured. Junin virus was recovered by cocultivation from peripheral blood mononuclear cells (PBMC) of 14 (70%) of 20 animals from 1 to 21 days after immunization; 27 (12%) of 223 PBMC samples that represented animals in all four dose groups were positive. In contrast, virus was recovered from the plasma of only two of 20 macaques (two of 225 samples [0.9%]), and only once (by amplification) from throat swabs. No evidence of reversion was detected in any blood isolate. All animals developed a detectable neutralizing antibody response following vaccination. These results indicate that Candid #1 is safe and immunogenic in nonhuman primates. RP MCKEE, KT (reprint author), USA,MED RES INST INFECT DIS,FREDERICK,MD 21701, USA. NR 20 TC 15 Z9 16 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD MAR PY 1993 VL 48 IS 3 BP 403 EP 411 PG 9 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA KX849 UT WOS:A1993KX84900015 PM 8385886 ER PT J AU JAN, LR YANG, CS HENCHAL, LS SUMIYOSHI, H SUMMERS, PL DUBOIS, DR LAI, CJ AF JAN, LR YANG, CS HENCHAL, LS SUMIYOSHI, H SUMMERS, PL DUBOIS, DR LAI, CJ TI INCREASED IMMUNOGENICITY AND PROTECTIVE EFFICACY IN OUTBRED AND INBRED MICE BY STRATEGIC CARBOXYL-TERMINAL TRUNCATION OF JAPANESE ENCEPHALITIS-VIRUS ENVELOPE GLYCOPROTEIN SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID MONOCLONAL-ANTIBODIES; STRUCTURAL PROTEINS; NUCLEOTIDE-SEQUENCE; MEMBRANE-PROTEINS; ANTIGENIC DETERMINANTS; FLAVIVIRUS; RESISTANCE; INFECTION; GENOME; GENE AB We constructed recombinant vaccinia viruses expressing the full-length envelope (E) glycoprotein of Japanese encephalitis virus (JEV) or a strategically truncated E glycoprotein, approximately 80% of the N-terminal sequence, and compared their antigenic structure and protective immunity in mice. The truncation site in the JEV E glycoprotein sequence corresponds to the position that had been shown to increase the immunogenicity of dengue type 4 or type 2 virus E glycoprotein. Analysis of the JEV E glycoprotein in recombinant virus-infected cells showed that C-terminally truncated E retains an antigenic structure similar to that of the full-length E glycoprotein. The full-length JEV E glycoprotein was detected predominantly intracellularly, while a small fraction (< 2%) was present on the cell surface. On the other hand, the truncated 80% E glycoprotein exhibited an alteration in the intracellular transport pathway resulting in increased accumulation (10-25%) on the cell surface and secretion (6-10%) into the medium. The C-terminally truncated E glycoprotein induced a greater antibody response and a higher level of protective immunity than did the full-length E glycoprotein in outbred CD-1 mice as well as in two strains of inbred mice that differ in their resistance to intraperitoneal (ip) JEV infection. In the case of outbred CD-1 and inbred C57/B1 mice, which possess a dominant autosomal genetic locus that controls resistance to a high dose of ip infection of JEV or the capacity to acquire resistance to intracerebral JEV infection, truncated E glycoprotein induced a higher titer of JEV neutralizing antibodies. C1 NATL TAIWAN UNIV,COLL MED,GRAD INST MICROBIOL,TAIPEI,TAIWAN. NATL INST PREVENT MED,TAIPEI,TAIWAN. WALTER REED ARMY INST RES,DEPT BIOL,WASHINGTON,DC 20307. RP JAN, LR (reprint author), NIAID,INFECT DIS LAB,MOLEC VIRAL BIOL SECT,BETHESDA,MD 20892, USA. NR 31 TC 30 Z9 31 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD MAR PY 1993 VL 48 IS 3 BP 412 EP 423 PG 12 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA KX849 UT WOS:A1993KX84900016 PM 8385887 ER PT J AU PORTER, KR SUMMERS, PL DUBOIS, D PURI, B NELSON, W HENCHAL, E OPRANDY, JJ HAYES, CG AF PORTER, KR SUMMERS, PL DUBOIS, D PURI, B NELSON, W HENCHAL, E OPRANDY, JJ HAYES, CG TI DETECTION OF WEST NILE VIRUS BY THE POLYMERASE CHAIN-REACTION AND ANALYSIS OF NUCLEOTIDE-SEQUENCE VARIATION SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article AB A polymerase chain reaction (PCR) assay was developed to rapidly detect and identify West Nile (WN) virus. The RNA from seven isolates of WN virus from six countries and four other flaviviruses (Kunjin, Japanese encephalitis, St. Louis encephalitis, and yellow fever viruses) was reverse-transcribed (RT) and amplified by PCR. The nucleotide sequences of the amplified products were determined by a rapid, automated DNA sequencing method. The WN virus RT/PCR assay detected the target gene segment of isolates from both the African-Middle Eastern group and the Indian group with a sensitivity of approximately 0.05 pg of viral RNA. Kunjin virus was the only other flavivirus tested that produced a band of the appropriate size. Five of seven WN virus isolates showed 92-98% homology in the nucleotide sequence of their PCR products. The sequence of one isolate was virtually identical to the published sequence of the Nigerian isolate (99.5% homology). No correlation was established between the degree of nucleotide homology, geographic location, time of isolation, or source of the isolates. C1 WALTER REED ARMY INST RES,WASHINGTON,DC 20307. RP PORTER, KR (reprint author), USN,MED RES INST,INFECT DIS THREAT ASSESSMENT PROGRAM,BETHESDA,MD 20814, USA. NR 10 TC 28 Z9 29 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD MAR PY 1993 VL 48 IS 3 BP 440 EP 446 PG 7 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA KX849 UT WOS:A1993KX84900019 PM 8470779 ER PT J AU LEMIRE, GW SIMEONSSON, JB SAUSA, RC AF LEMIRE, GW SIMEONSSON, JB SAUSA, RC TI MONITORING OF VAPOR-PHASE NITRO-COMPOUNDS USING 226-NM RADIATION - FRAGMENTATION WITH SUBSEQUENT NO RESONANCE-ENHANCED MULTIPHOTON IONIZATION DETECTION SO ANALYTICAL CHEMISTRY LA English DT Article ID FLUORESCENCE SPECTROMETRIC DETERMINATION; MULTI-PHOTON IONIZATION; MASS-SPECTROMETRY; LASER-PHOTOLYSIS; PHOTODISSOCIATION; DIMETHYLNITRAMINE; NM; DISTRIBUTIONS; DISSOCIATION; DYNAMICS AB The development of a novel technique for sensing trace vapors of NO2-containing compounds is reported. This technique is based on the use of one laser operating at 226 nm to both photofragment the target molecule and detect the characteristic NO fragment, formed from a rapid predissociation of NO2, by resonance-enhanced multiphoton ionization (REMPI) and/or laser-induced fluorescence (LIF) via its A2SIGMA+-X2PI (0,0) band origin. The analytical utility of this technique is demonstrated on a number of compounds, including dimethylnitramine, nitromethane, nitrobenzene, trinitrotoluene (TNT), and 1,3,5-trinitrohexahydro-1,3,5-triazine (RDX), employing molecular beam sampling with time-of-flight mass spectrometric analysis of the jet-cooled analyte seeded in an atmosphere of buffer gas. With the present system, limits of detection of 8 and 24 parts per billion (ppb) are obtained for ROX and TNT, respectively, using only approximately 100 muJ/pulse of laser energy. The limits of detection of the other compounds studied are also presented and discussed. C1 USA,RES LAB,AMSRL,WT,PC,ABERDEEN PROVING GROUND,MD 21005. NR 31 TC 56 Z9 57 U1 4 U2 14 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0003-2700 J9 ANAL CHEM JI Anal. Chem. PD MAR 1 PY 1993 VL 65 IS 5 BP 529 EP 533 DI 10.1021/ac00053a008 PG 5 WC Chemistry, Analytical SC Chemistry GA KN683 UT WOS:A1993KN68300009 ER PT J AU MCCAMBRIDGE, MM ELIASSON, AH AF MCCAMBRIDGE, MM ELIASSON, AH TI LUNG-CANCER IN THE YOUNG SO ANNALS OF THORACIC SURGERY LA English DT Letter ID BRONCHOGENIC-CARCINOMA RP MCCAMBRIDGE, MM (reprint author), WALTER REED ARMY MED CTR,DEPT MED,WASHINGTON,DC 20307, USA. NR 8 TC 4 Z9 4 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0003-4975 J9 ANN THORAC SURG JI Ann. Thorac. Surg. PD MAR PY 1993 VL 55 IS 3 BP 809 EP 810 PG 2 WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery SC Cardiovascular System & Cardiology; Respiratory System; Surgery GA KT989 UT WOS:A1993KT98900059 PM 8452465 ER PT J AU CHARNOCK, DR CHAPMAN, GD WOZNIAK, A TAYLOR, RE AF CHARNOCK, DR CHAPMAN, GD WOZNIAK, A TAYLOR, RE TI RECURRENT TONSILLITIS - THE ROLE OF CHLAMYDIA AND MYCOPLASMA - REPLY SO ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY LA English DT Letter ID TRACHOMATIS; CULTURE; INFANTS C1 USA,WASHINGTON,DC 20310. USN,RUTLAND,VT. RP CHARNOCK, DR (reprint author), USNR,WASHINGTON,DC, USA. NR 7 TC 0 Z9 0 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0886-4470 J9 ARCH OTOLARYNGOL JI Arch. Otolaryngol. Head Neck Surg. PD MAR PY 1993 VL 119 IS 3 BP 355 EP 356 PG 2 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA KQ559 UT WOS:A1993KQ55900019 ER PT J AU WILLIAMS, SB BUTLER, BC GILKEY, FW KAPADIA, SB BURTON, DM AF WILLIAMS, SB BUTLER, BC GILKEY, FW KAPADIA, SB BURTON, DM TI EPITHELIOID HEMANGIOENDOTHELIOMA WITH OSTEOCLAST-LIKE GIANT-CELLS SO ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE LA English DT Note ID THYROID-CARCINOMA; TUMOR; TISSUE AB This article describes histopathologic and immunohistologic features of an epithelioid hemangioendothelioma that presented in the neck of a 40-year-old man. This tumor was unusual because of the presence of osteoclastlike giant cells scattered throughout the entire lesion. The tumor cells reacted positively for factor VIII-related antigen, and the osteoclastlike giant cells were reactive for KP1 antibody, a macrophage-associated antigen. We are aware of only one other previously reported example of soft-tissue epithelioid hemangioendothelioma with an abundance of osteoclastlike giant cells. C1 ARMED FORCES INST PATHOL,DEPT OTOLARYNG PATHOL,WASHINGTON,DC 20306. ARMED FORCES INST PATHOL,DEPT ORTHOPED SURG,WASHINGTON,DC 20306. WALTER REED ARMY MED CTR,DEPT ANAT PATHOL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT OTORHINOLARYNGOL,WASHINGTON,DC 20307. RP WILLIAMS, SB (reprint author), ARMED FORCES INST PATHOL,DEPT ORAL PATHOL,WASHINGTON,DC 20306, USA. NR 22 TC 8 Z9 9 U1 0 U2 0 PU COLLEGE AMER PATHOLOGISTS PI NORTHFIELD PA C/O KIMBERLY GACKI, 325 WAUKEGAN RD, NORTHFIELD, IL 60093-2750 SN 0003-9985 J9 ARCH PATHOL LAB MED JI Arch. Pathol. Lab. Med. PD MAR PY 1993 VL 117 IS 3 BP 315 EP 318 PG 4 WC Medical Laboratory Technology; Medicine, Research & Experimental; Pathology SC Medical Laboratory Technology; Research & Experimental Medicine; Pathology GA KQ558 UT WOS:A1993KQ55800019 PM 8442675 ER PT J AU ROBINSON, MD HUSSEY, RW HA, CY AF ROBINSON, MD HUSSEY, RW HA, CY TI SURGICAL DECOMPRESSION OF IMPINGEMENT IN THE WEIGHTBEARING SHOULDER SO ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION LA English DT Note DE HUMAN; MALE; MOVEMENT; PAIN; PARAPLEGIA; REHABILITATION; SPINAL CORD INJURY; SHOULDER; SURGERY ID WHEELCHAIR C1 HUNTER HOLMES MCGUIRE VET AFFAIRS MED CTR,SPINAL CORD INJURY SERV,RICHMOND,VA. RP ROBINSON, MD (reprint author), WALTER REED ARMY MED CTR,PHYS MED & REHABIL SERV,WASHINGTON,DC 20307, USA. NR 14 TC 21 Z9 21 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0003-9993 J9 ARCH PHYS MED REHAB JI Arch. Phys. Med. Rehabil. PD MAR PY 1993 VL 74 IS 3 BP 324 EP 327 PG 4 WC Rehabilitation; Sport Sciences SC Rehabilitation; Sport Sciences GA KQ118 UT WOS:A1993KQ11800018 PM 8439264 ER PT J AU COLLINS, JJ AF COLLINS, JJ TI THE DYNAMICS OF DOMESTIC POLITICS AND ARMS-CONTROL - THE SALT-II TREATY RATIFICATION DEBATE - CALDWELL,D SO ARMED FORCES & SOCIETY LA English DT Book Review RP COLLINS, JJ (reprint author), US MIL ACAD,DEPT SOCIAL SCI,W POINT,NY 10996, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU TRANSACTION PERIOD CONSORTIUM PI NEW BRUNSWICK PA DEPT 3091 RUTGERS-THE STATE UNIV OF NJ, NEW BRUNSWICK, NJ 08903 SN 0095-327X J9 ARMED FORCES SOC JI Armed Forces Soc. PD SPR PY 1993 VL 19 IS 3 BP 462 EP 464 DI 10.1177/0095327X9301900314 PG 3 WC Political Science; Sociology SC Government & Law; Sociology GA LA698 UT WOS:A1993LA69800012 ER PT J AU SHERMAN, RA AF SHERMAN, RA TI THE PAIN CLINIC MANUAL - ABRAM,SE SO BIOFEEDBACK AND SELF-REGULATION LA English DT Book Review C1 FITZSIMONS ARMY MED CTR,DEPT CLIN INVEST,CLIN BIOMETR SERV,AURORA,CO 80045. RP SHERMAN, RA (reprint author), USA,MED SERV,WASHINGTON,DC 20310, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU PLENUM PUBL CORP PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 SN 0363-3586 J9 BIOFEEDBACK SELF-REG JI Biofeedback Self-Regul. PD MAR PY 1993 VL 18 IS 1 BP 61 EP 63 PG 3 WC Psychology, Clinical SC Psychology GA KR743 UT WOS:A1993KR74300007 ER PT J AU BAGGOT, JD BUCKPITT, A JOHNSON, D BRENNAN, P CHUNG, H AF BAGGOT, JD BUCKPITT, A JOHNSON, D BRENNAN, P CHUNG, H TI BIOAVAILABILITY AND DISPOSITION KINETICS OF HI-6 IN BEAGLE DOGS SO BIOPHARMACEUTICS & DRUG DISPOSITION LA English DT Article DE HI-6; PHARMACOKINETICS; BEAGLE DOGS; CHOLINESTERASE REACTIVATOR ID CHOLINESTERASE REACTIVATOR HI-6; ACETYLCHOLINESTERASE REACTIVATORS; TABUN; SOMAN; OXIME; PHARMACOKINETICS; EFFICACY; RATS; SARIN; MICE AB The absorption and disposition kinetics of HI-6 were determined in Beagle dogs given single doses (25 mg kg-1) of the drug by the intravenous, intramuscular, and oral routes. Concentrations of the oxime in plasma and urine were measured by HPLC. A two-compartment open model was used to describe the disposition curve following intravenous drug administration while a one-compartment open model with first-order absorption adequately described the data following intramuscular or oral administration of the dose. Extravascular distribution of HI-6 was limited (V(ss) 203 ml kg-1) and the drug was eliminated rapidly after intravenous administration (t1/2 46.5 min, MAT 55.4 min). Systemic clearance was 3.68 ml min-1 x kg. A major fraction of the dose (63.7 per cent) was excreted in urine over a 24-h collection period. Following intramuscular drug administration, the absorption half-life (t1/2(a), 5.3 min), MAT (17.1 min), C(max) (70.37 mug ml-1) and t(max)(15.9 min) indicate that the drug was rapidly absorbed. Systemic availability was 83.43 per cent after oral drug administration, absorption was preceded by a lag time (23.2 min). The t1/2(a)(41.5 min), MAT(81.6 min), C(max)(4.30 mug ml-1) and T(max)(90.6 min) indicate somewhat delayed absorption. Systemic availability (11.38 per cent) and the fraction of dose excreted unchanged in the urine (9.3 per cent) show that the drug was poorly absorbed. The apparent half-life (58.0 min) and MRT (137.6 min) following oral administration were significantly longer (p<0.05) than following intravenous or intramuscular administration suggesting that the rate of absorption from the gastrointestinal tract decreases the elimination rate of the drug. In conclusion, HI-6 has limited distribution within the body, is rapidly eliminated mainly by renal excretion unchanged in the urine, and the bioavailability (i.e. rate and extent of absorption) of the drug varies with the route of administration. C1 UC DAVIS,SCH VET MED,DEPT PHARMACOL & TOXICOL,HARING HALL,DAVIS,CA 95616. IRISH EQUINE CTR,JOHNSTOWN,IRELAND. UNIV CALIF DAVIS,OCCUPAT ENVIRONM HLTH UNIT,DAVIS,CA 95616. WALTER REED ARMY INST RES,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307. NR 24 TC 5 Z9 5 U1 0 U2 3 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0142-2782 J9 BIOPHARM DRUG DISPOS JI Biopharm. Drug Dispos. PD MAR PY 1993 VL 14 IS 2 BP 93 EP 105 DI 10.1002/bdd.2510140202 PG 13 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA KQ246 UT WOS:A1993KQ24600001 PM 8453028 ER PT J AU GANTT, JD BEISE, CM AF GANTT, JD BEISE, CM TI THE PUBLIC REACTS TO GDSS SO BYTE LA English DT Article C1 W GEORGIA COLL,CARROLLTON,GA 30117. RP GANTT, JD (reprint author), USA,RES LAB,ATLANTA,GA, USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU BYTE PUBL INC PI PETERBOROUGH PA 70 MAIN ST, PETERBOROUGH, NH 03458 SN 0360-5280 J9 BYTE JI Byte PD MAR PY 1993 VL 18 IS 3 BP 118 EP 118 PG 1 WC Computer Science, Hardware & Architecture; Computer Science, Software Engineering SC Computer Science GA KM308 UT WOS:A1993KM30800026 ER PT J AU BLANEY, SM BALIS, FM COLE, DE CRAIG, C REID, JM AMES, MM KRAILO, M REAMAN, G HAMMOND, D POPLACK, DG AF BLANEY, SM BALIS, FM COLE, DE CRAIG, C REID, JM AMES, MM KRAILO, M REAMAN, G HAMMOND, D POPLACK, DG TI PEDIATRIC PHASE-I TRIAL AND PHARMACOKINETIC STUDY OF TOPOTECAN ADMINISTERED AS A 24-HOUR CONTINUOUS INFUSION SO CANCER RESEARCH LA English DT Article ID LINKED DNA BREAKS; CAMPTOTHECIN NSC-100880; TOPOISOMERASE-I AB Topotecan, a water-soluble semisynthetic analogue of camptothecin, is the first topoisomerase I inhibitor to undergo evaluation in pediatric patients with refractory malignancies. A phase I and pharmacokinetic study was performed to determine the maximum tolerated dose (MTD) and dose-limiting toxicities, the incidence and severity of other toxicities, and the pharmacokinetics of topotecan in children. Twenty-nine patients received 42-courses of i.v. topotecan administered as a 24-h continuous infusion every 21 days at doses ranging from 2.0 to 7.5 mg/m2. Dose-related hematological toxicity was the dose-limiting toxicity. Leukopenia, neutropenia, and thrombocytopenia occurred sporadically at the 3.0- to 5.5-mg/m2 dose levels, but at 7.5 mg/m2 4 of 5 patients experienced dose-limiting thrombocytopenia (grade 4) and 2 of 5 had dose-limiting neutropenia (grade 4). No other dose-limiting toxicities were observed. Nausea and vomiting were mild and occurred in <20 and 10% of patients, respectively. Grade 2 hematuria occurred in one patient. No objective responses were observed. Pharmacokinetic studies revealed a linear relationship between the steady-state topotecan concentration and dose. The mean steady-state concentration at the MTD was 18.2 +/- 3.7 nmol/liter and the total body clearance was 28.3 +/- 6.5 liters/h/m2. Elimination was biexponential with a t1/2alpha of 14.4 +/- 1.8 min and a t1/2beta of 2.9 +/- 1.1 h. The recommended starting dose for phase 11 pediatric trials is 5.5 mg/m2. Although this dose exceeds the MTD identified in heavily pretreated adult patients receiving topotecan on the same schedule, it is less than the MTD for minimally pretreated adult patients. Therefore, dose escalation to 7.5 mg/m2 in phase II pediatric trials should be considered for patients who tolerate treatment well at the 5.5-mg/m2 dose. C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. CHILDRENS STUDY CANC GRP,ARCADIA,CA 91006. RP BLANEY, SM (reprint author), NCI,PEDIAT BRANCH,BLDG 10,ROOM 13N240,9000 ROCKVILLE PIKE,BETHESDA,MD 20892, USA. FU NCI NIH HHS [CA13539] NR 24 TC 96 Z9 96 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA PUBLIC LEDGER BLDG, SUITE 816, 150 S. INDEPENDENCE MALL W., PHILADELPHIA, PA 19106 SN 0008-5472 J9 CANCER RES JI Cancer Res. PD MAR 1 PY 1993 VL 53 IS 5 BP 1032 EP 1036 PG 5 WC Oncology SC Oncology GA KN706 UT WOS:A1993KN70600017 PM 8439950 ER PT J AU HNATIUK, OW PIKE, J STOLTZFUS, D LANE, W AF HNATIUK, OW PIKE, J STOLTZFUS, D LANE, W TI VALUE OF BEDSIDE PLATING OF SEMIQUANTITATIVE CULTURES FOR DIAGNOSIS OF CENTRAL VENOUS CATHETER-RELATED INFECTIONS IN ICU PATIENTS SO CHEST LA English DT Article ID TRIPLE-LUMEN; SINGLE-LUMEN; RAPID DIAGNOSIS; SEPSIS AB We compared semiquantitative central venous catheter tip cultures plated at the bedside with those cultured in the laboratory, to determine if bedside plating provides a significantly better yield. Paired segments of 197 catheter tips from 92 surgical and medical ICU patients were evaluated prospectively. A total of 31 catheter tip cultures were positive for greater-than-or-equal-to 15 organisms per agar plate, with 10 of these being simultaneously positive at the bedside and in the laboratory. Cultures were exclusively positive in 18 cases plated immediately at the bedside, whereas laboratory plating resulted in only 3 exclusively positive cases. This discrepancy was statistically significant (p<0.005). Compared with bedside plating, the sensitivity and specificity of sending catheters to the laboratory were 36 percent and 98 percent, respectively. These results indicate that the practice of sending central venous catheter tips to the laboratory for routine culture should be reconsidered in favor of bedside plating. C1 WALTER REED ARMY MED CTR,DEPT MED,CRIT CARE SERV,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT SURG,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. RP HNATIUK, OW (reprint author), WALTER REED ARMY MED CTR,DEPT MED,PULM DIS SERV,WASHINGTON,DC 20307, USA. NR 16 TC 2 Z9 2 U1 0 U2 0 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 SN 0012-3692 J9 CHEST JI Chest PD MAR PY 1993 VL 103 IS 3 BP 896 EP 899 DI 10.1378/chest.103.3.896 PG 4 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA KQ382 UT WOS:A1993KQ38200047 PM 8449088 ER PT J AU NOCERA, JJ MATTHEWS, GP SIMMONS, TM AF NOCERA, JJ MATTHEWS, GP SIMMONS, TM TI SAMPLING SEDIMENT ON A COMPLEX SITE SO CIVIL ENGINEERING LA English DT Article C1 USA,CORPS ENGINEERS,KANSAS CITY,MO. RP NOCERA, JJ (reprint author), MALCOLM PIRNIE INC,HAZARDOUS WASTE GRP,MARATHON BATTERY PROJECT,WHITE PLAINS,NY, USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU ASCE-AMER SOC CIVIL ENGINEERS PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0885-7024 J9 CIVIL ENG JI Civil Eng. PD MAR PY 1993 VL 63 IS 3 BP 54 EP 56 PG 3 WC Engineering, Civil SC Engineering GA KP773 UT WOS:A1993KP77300025 ER PT J AU SOMMERS, RJ AF SOMMERS, RJ TI THE LAST CITADEL - PETERSBURG, VIRGINIA, JUNE 1864 APRIL 1865 - TRUDEAU,NA SO CIVIL WAR HISTORY LA English DT Book Review RP SOMMERS, RJ (reprint author), USA,INST MIL HIST,WASHINGTON,DC 20310, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU KENT STATE UNIV PRESS PI KENT PA KENT, OH 44242 SN 0009-8078 J9 CIVIL WAR HIST JI Civil War Hist. PD MAR PY 1993 VL 39 IS 1 BP 69 EP 71 PG 3 WC History SC History GA KU295 UT WOS:A1993KU29500005 ER PT J AU LOOAREESUWAN, S SUNTHARASAMAI, P WEBSTER, HK HO, M AF LOOAREESUWAN, S SUNTHARASAMAI, P WEBSTER, HK HO, M TI MALARIA IN SPLENECTOMIZED PATIENTS - REPORT OF 4 CASES AND REVIEW SO CLINICAL INFECTIOUS DISEASES LA English DT Article ID PLASMODIUM-FALCIPARUM MALARIA; ERYTHROCYTES AB The spleen plays a central role in host defense against malaria in animals. Its role in human malaria is less well established. The spleen may contribute to protection against human malaria by mediating humoral or cellular immune responses or by clearing both rheologically and immunologically altered host erythrocytes. This report describes Plasmodium falciparum and Plasmodium vivax infections that occurred after splenectomy in one nonimmune and three partially immune Thai adults. The clinical course was uncomplicated for all four patients, and parasite clearance was delayed only in the nonimmune patient. In three patients with falciparum malaria, humoral and cellular immune responses to blood-stage antigens during the acute infection and convalescence were similar to those of individuals whose spleens were intact. These findings suggest that the spleen may not be essential for the processes leading to parasite clearance in partially immune, splenectomized patients. Further studies on the course of malarial infections in splenectomized patients are crucial for clarifying the role of the spleen in host defense against human malaria. C1 MAHIDOL UNIV,FAC TROP MED,HOSP TROP DIS,BANGKOK 10700,THAILAND. ARMED FORCES RES INST MED SCI,USA COMPONENT,BANGKOK,THAILAND. UNIV CALGARY,DEPT MICROBIOL & INFECT DIS,CALGARY T2N 1N4,ALBERTA,CANADA. UNIV CALGARY,DEPT MED,CALGARY T2N 1N4,ALBERTA,CANADA. NR 27 TC 55 Z9 56 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD MAR PY 1993 VL 16 IS 3 BP 361 EP 366 PG 6 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA KN242 UT WOS:A1993KN24200003 PM 8452947 ER PT J AU SINOFF, SE HART, MB AF SINOFF, SE HART, MB TI TOPICAL CAPSAICIN AND BURNING PAIN SO CLINICAL JOURNAL OF PAIN LA English DT Letter ID REFLEX SYMPATHETIC DYSTROPHY C1 WALTER REED ARMY MED CTR,MED CORPS,NUCL MED SERV,WASHINGTON,DC 20307. RP SINOFF, SE (reprint author), WALTER REED ARMY MED CTR,MED CORPS,HSHL NR,NEUROOPTHALMOL SERV,WASHINGTON,DC 20307, USA. NR 4 TC 5 Z9 5 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0749-8047 J9 CLIN J PAIN JI Clin. J. Pain PD MAR PY 1993 VL 9 IS 1 BP 70 EP 73 DI 10.1097/00002508-199303000-00035 PG 4 WC Anesthesiology; Clinical Neurology SC Anesthesiology; Neurosciences & Neurology GA KT859 UT WOS:A1993KT85900009 PM 8477142 ER PT J AU WISWELL, TE HACHEY, WE AF WISWELL, TE HACHEY, WE TI URINARY-TRACT INFECTIONS AND THE UNCIRCUMCISED STATE - AN UPDATE SO CLINICAL PEDIATRICS LA English DT Article ID CIRCUMCIZED MALE INFANTS; META-ANALYSIS; DECREASED INCIDENCE; TRIALS AB In a two-part study of the circumcision status of boys with urinary tract infections (UTIs), we reviewed the occurrence of UTIs in 209,399 infants born in US Army hospitals worldwide from 1985 to 1990. During the first year of life, 1,046 (0.5%: 550 girls and 496 boys) were hospitalized for UTIs. Noncircumcised male infants had a 10-fold greater incidence of infection than did circumcised male infants. The frequency rate of circumcision rose significantly, from 70.3% to 80.2%, during the study period. Among uncircumcised boys younger than 3 months with UTIs, 23% had concomitant bacteremia involving the same organism. The second part of the study consisted of a meta-analysis of all nine previous reports on the circumcision status of boys with UTIs. These studies revealed a fivefold to 89-fold increased risk of infection in uncircumcised boys; the combined data yielded a 12-fold increase in UTIs in this population. Parents should be told of the lower risk of UTIs for circumcised boys during informed-consent counseling. RP WISWELL, TE (reprint author), WALTER REED ARMY MED CTR,DEPT PEDIAT,NEONATOL SERV,WASHINGTON,DC 20307, USA. NR 37 TC 92 Z9 93 U1 0 U2 0 PU WESTMINSTER PUBL INC PI GLEN HEAD PA 708 GLEN COVE AVE, GLEN HEAD, NY 11545 SN 0009-9228 J9 CLIN PEDIATR JI Clin. Pediatr. PD MAR PY 1993 VL 32 IS 3 BP 130 EP 134 DI 10.1177/000992289303200301 PG 5 WC Pediatrics SC Pediatrics GA KT998 UT WOS:A1993KT99800001 PM 8453827 ER PT J AU MOORE, J CAROME, MA AF MOORE, J CAROME, MA TI PROTEINURIA SO CLINICS IN LABORATORY MEDICINE LA English DT Article RP MOORE, J (reprint author), WALTER REED ARMY MED CTR,DEPT MED,NEPHROL SERV,WASHINGTON,DC 20307, USA. NR 0 TC 2 Z9 2 U1 0 U2 2 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0272-2712 J9 CLIN LAB MED JI Clin. Lab. Med. PD MAR PY 1993 VL 13 IS 1 BP 21 EP 31 PG 11 WC Medical Laboratory Technology SC Medical Laboratory Technology GA KU022 UT WOS:A1993KU02200004 PM 8462262 ER PT J AU MACHAN, TR AF MACHAN, TR TI GAY RIGHTS SO COMMENTARY LA English DT Letter RP MACHAN, TR (reprint author), US MIL ACAD,W POINT,NY 10996, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER JEWISH COMMITTEE PI NEW YORK PA 165 E 56TH ST, NEW YORK, NY 10022 SN 0010-2601 J9 COMMENTARY JI Commentary PD MAR PY 1993 VL 95 IS 3 BP 15 EP 15 PG 1 WC Political Science; Social Issues SC Government & Law; Social Issues GA KN054 UT WOS:A1993KN05400025 ER PT J AU BIRENZVIGE, A STURDIVAN, LM FAMINI, GR KRISHNAN, PN AF BIRENZVIGE, A STURDIVAN, LM FAMINI, GR KRISHNAN, PN TI ESTIMATING PHYSICAL-PROPERTIES OF CHEMICAL-COMPOUNDS - PROBLEM REVISITED SO COMPUTERS & CHEMISTRY LA English DT Article AB The physical and chemical properties of various molecules, calculated by three different semi-empirical methods (MNDO, AM1 and PM3) are compared to experimental values using rigorous statistical analysis. The results show that the best method for calculating physical/chemical properties depends on the property and that no one method is adequate to calculate all the physical properties. Furthermore, by employing appropriate statistical tools we arc able to determine the precision and accuracy that each method calculates the different physical/chemical properties. This will make it possible to use computational chemistry as a predictive tool with much better confidence. C1 COPPIN STATE COLL,BALTIMORE,MD 21216. RP BIRENZVIGE, A (reprint author), USA,CTR CHEM RES DEV & ENGN,DIV DETECT TECHNOL,ABERDEEN PROVING GROUND,MD 21010, USA. NR 3 TC 2 Z9 2 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0097-8485 J9 COMPUT CHEM JI Comput. Chem. PD MAR PY 1993 VL 17 IS 1 BP 33 EP 47 DI 10.1016/0097-8485(93)80027-B PG 15 WC Chemistry, Multidisciplinary; Computer Science, Interdisciplinary Applications SC Chemistry; Computer Science GA KX590 UT WOS:A1993KX59000006 ER PT J AU FISHER, CJ OPAL, SM DHAINAUT, JF STEPHENS, S ZIMMERMAN, JL NIGHTINGALE, P HARRIS, SJ SCHEIN, RMH PANACEK, EA VINCENT, JL FOULKE, GE WARREN, EL GARRARD, C PARK, G BODMER, MW COHEN, J VANDERLINDEN, C CROSS, AS SADOFF, JC FISHER, CJ PANACEK, EA WARREN, EL GORECKI, J OPAL, SM DUBIN, HG GARNER, C KAYE, W DHAINAUT, JF LANORE, JJ MIRA, JP STEPHENS, S HARRIS, SJ BODMER, MW ZIMMERMAN, J DELLINGER, RP TAYLOR, RW DAHL, S NIGHTINGALE, P SHELLY, M MORTIMER, A EDWARDS, JD SCHEIN, RMH KETT, DH QUARTIN, A PENA, MA VINCENT, JL BAKKER, J FOULKE, GE ALBERSON, TE WALBY, W RADCLIFFE, J GARRARD, C YOUNG, D MCQUILLAM, P PARK, G COHEN, J BELLINGHAM, G VANDERLINDEN, C BURMAN, W CROSS, AS SADOFF, JS YOUNG, L AF FISHER, CJ OPAL, SM DHAINAUT, JF STEPHENS, S ZIMMERMAN, JL NIGHTINGALE, P HARRIS, SJ SCHEIN, RMH PANACEK, EA VINCENT, JL FOULKE, GE WARREN, EL GARRARD, C PARK, G BODMER, MW COHEN, J VANDERLINDEN, C CROSS, AS SADOFF, JC FISHER, CJ PANACEK, EA WARREN, EL GORECKI, J OPAL, SM DUBIN, HG GARNER, C KAYE, W DHAINAUT, JF LANORE, JJ MIRA, JP STEPHENS, S HARRIS, SJ BODMER, MW ZIMMERMAN, J DELLINGER, RP TAYLOR, RW DAHL, S NIGHTINGALE, P SHELLY, M MORTIMER, A EDWARDS, JD SCHEIN, RMH KETT, DH QUARTIN, A PENA, MA VINCENT, JL BAKKER, J FOULKE, GE ALBERSON, TE WALBY, W RADCLIFFE, J GARRARD, C YOUNG, D MCQUILLAM, P PARK, G COHEN, J BELLINGHAM, G VANDERLINDEN, C BURMAN, W CROSS, AS SADOFF, JS YOUNG, L TI INFLUENCE OF AN ANTITUMOR NECROSIS FACTOR MONOCLONAL-ANTIBODY ON CYTOKINE LEVELS IN PATIENTS WITH SEPSIS SO CRITICAL CARE MEDICINE LA English DT Article DE SEPSIS; SHOCK, SEPTIC; IMMUNOTHERAPY; TUMOR NECROSIS FACTOR; MONOCLONAL ANTIBODY; ANTI-CYTOKINE; INTERLEUKIN-1; INTERLEUKIN-6; CRITICAL ILLNESS; INFECTION ID NEGATIVE BACTERIAL SEPSIS; SEPTIC SHOCK; ENDOTOXIC-SHOCK; INTERLEUKIN-1; SERUM; BACTEREMIA; MORTALITY; CACHECTIN; ASSOCIATION; KINETICS AB Objectives: To determine the safety, pharmacokinetics, and activity of an anti-tumor necrosis factor (TNF)-alpha monoclonal antibody in severe sepsis. Design: Open-label, prospective, phase II multicenter trial with escalating doses of a murine monoclonal antibody (CB0006). Setting. Twelve academic medical center in tensive care units in the United States and Europe. Patients: Eighty patients with severe sepsis or septic shock who received standard supportive care and antimicrobial therapy in addition to the anti-TNF antibody. Interventions. Patients were treated intravenously with one of four dosing regimens with CB0006: 0.1 mg/kg, 1.0 mg/kg, 10 mg/kg or two doses of 1 mg/kg 24 hrs apart. Measurements and Main Results. The murine monoclonal anti-TNF antibody was well tolerated despite the development of anti-murine antibodies in 98% of patients. No survival benefit was found for the total study population, but patients with increased circulating TNF concentrations at study entry appeared to benefit by the high dose anti-TNF antibody treatment. Increased interleukin (EL)-6 levels predicted a fatal outcome (p =.003), but TNF levels were not found to be a prognostic indicator. TNF levels were higher (206.7 +/- 60.7 vs. 85.9 +/- 26.1 pg/mL;p <.001) and outcome was poor (41% vs. 71% survival; p = .007) in patients who were in shock at study entry when compared with septic patients not in shock. Conclusions. The murine anti-TNF-alpha monoclonal antibody CB0006 has proven to be safe in this clinical trial and may prove to be useful in septic patients with increased circulating TNF concentrations. Further studies are needed to determine efficacy and the ultimate clinical utility of this immunotherapeutic agent in sepsis. C1 CASE WESTERN RESERVE UNIV,CLEVELAND,OH 44106. BROWN UNIV,DEPT MED,DAWTUCKET,RI. CELLTECH LTD,SLOUGH,ENGLAND. COCHIN PORT ROYAL UNIV,PARIS,FRANCE. BAYLOR COLL MED,DEPT MED,HOUSTON,TX 77030. UNIV S MANCHESTER,DEPT ANESTHET & INTENS CARE,MANCHESTER,ENGLAND. VET ADM MED CTR,MIAMI,FL 33125. CASE WESTERN RESERVE UNIV,CTR CRIT CARE RES,CLEVELAND,OH 44106. FREE UNIV BRUSSELS,ERASME HOSP,B-1050 BRUSSELS,BELGIUM. UNIV CALIF DAVIS,SACRAMENTO MED CTR,MED CTR,SACRAMENTO,CA 95817. JOHN RADCLIFFE HOSP,DEPT ANESTHET & INTENS THERAPY,OXFORD OX3 9DU,ENGLAND. ADDENBROOKES HOSP,DEPT ANESTHET & INTENS CARE,CAMBRIDGE CB2 2QQ,ENGLAND. HAMMERSMITH HOSP,DEPT MED,LONDON W12 0HS,ENGLAND. UNIV MAASTRICHT,DEPT SURG,MAASTRICHT,NETHERLANDS. WALTER REED ARMY INST RES,DEPT INFECT DIS,WASHINGTON,DC 20307. RP FISHER, CJ (reprint author), CLEVELAND CLIN FDN,DEPT PULM & CRIT CARE MED,CRIT CARE RES UNIT,9500 EUCLID AVE,CLEVELAND,OH 44195, USA. RI Bakker, Jan/A-4011-2009 OI Bakker, Jan/0000-0003-2236-7391 NR 50 TC 355 Z9 358 U1 1 U2 2 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD MAR PY 1993 VL 21 IS 3 BP 318 EP 327 DI 10.1097/00003246-199303000-00006 PG 10 WC Critical Care Medicine SC General & Internal Medicine GA KQ902 UT WOS:A1993KQ90200006 PM 8440099 ER PT J AU HATCH, RT CARPENTER, GB SMITH, LJ AF HATCH, RT CARPENTER, GB SMITH, LJ TI TREATMENT OPTIONS IN THE CHILD WITH A CHRONIC COUGH SO DRUGS LA English DT Article AB Chronic cough is a common symptom in many different disease processes. Because the most effective way to eliminate a chronic cough is to identify and treat the underlying disease, the physician must approach the paediatric patient based on his or her knowledge of the differential diagnosis. The most common causes of cough in children are upper respiratory tract infections, asthma, rhinitis, sinusitis, and gastroesophageal reflux. By using a systematic approach, the cause of a chronic cough can almost always be found, and the cough successfully treated. Asthma is the cause of most undiagnosed chronic coughs but sinusitis, rhinitis, and gastroesophageal reflux must also be considered in difficult patients. C1 WALTER REED ARMY INST RES,ALLERGY & IMMUNOL SERV,WASHINGTON,DC 20307. NR 19 TC 6 Z9 6 U1 0 U2 0 PU ADIS INTERNATIONAL LTD PI AUCKLAND PA 41 CENTORIAN DR, PRIVATE BAG 65901, MAIRANGI BAY, AUCKLAND 10, NEW ZEALAND SN 0012-6667 J9 DRUGS JI Drugs PD MAR PY 1993 VL 45 IS 3 BP 367 EP 373 PG 7 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA KU719 UT WOS:A1993KU71900005 PM 7682907 ER PT J AU ROSKIN, MG AF ROSKIN, MG TI THE EMERGING PARTY SYSTEMS OF CENTRAL AND EASTERN-EUROPE SO EAST EUROPEAN QUARTERLY LA English DT Article RP ROSKIN, MG (reprint author), USA,COLL WAR,WASHINGTON,DC 20310, USA. NR 16 TC 7 Z9 7 U1 0 U2 0 PU EAST EUROPEAN QUARTERLY PI BOULDER PA BOX 29 REGENT HALL UNIV COLORADO, BOULDER, CO 80309 SN 0012-8449 J9 E EUR QUART JI East European Q. PD SPR PY 1993 VL 27 IS 1 BP 47 EP 63 PG 17 WC Area Studies SC Area Studies GA KR697 UT WOS:A1993KR69700002 ER PT J AU JABBARI, B COATS, M SALAZAR, A MARTIN, A SCHEROKMAN, B LAWS, WA AF JABBARI, B COATS, M SALAZAR, A MARTIN, A SCHEROKMAN, B LAWS, WA TI LONGITUDINAL-STUDY OF EEG AND EVOKED-POTENTIALS IN NEUROLOGICALLY ASYMPTOMATIC HIV-INFECTED SUBJECTS SO ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY LA English DT Article DE HIV INFECTION; AIDS; ELECTROCEPHALOGRAM; EVOKED POTENTIALS; ASYMPTOMATIC SUBJECTS ID HUMAN-IMMUNODEFICIENCY-VIRUS; NERVOUS-SYSTEM; AIDS; MANIFESTATIONS; ABNORMALITIES; DEMENTIA; SPECTRUM; COMPLEX; BRAIN AB Serial electroencephalograms (EEGs) and multimodality evoked potentials (EPs) were performed along with neurological and neuropsychological evaluation, cerebrospinal fluid assessment and magnetic resonance imaging at 6 month intervals in 73 neurologically asymptomatic HIV infected subjects. The results were compared with 50 age- and sex-matched controls. EEG was abnormal in 2 subjects (3%) initially and was abnormal in 7 (9%) subjects by the last examination. EEG abnormality (diffuse slowing) correlated significantly with slowed reaction time in neuropsychological testing (P < 0.05). VEP and BAEP provided low yields of 1.3% and 4% respectively. SEP was abnormal in 7 (9%) of the subjects initially and in 10 (13%) subjects by the last testing, with 80% of the abnormalities seen on the posterior tibial study. In 3 subjects, initial SEP abnormalities predicted later development of myelopathy and peripheral neuropathy. Event-related auditory evoked potentials were performed in 39 subjects. They were abnormal in 5 subjects initially (12%) and in 6 subjects (15%) by the last examination and more commonly in advanced stages of the illness with lower T4 counts. This data shows the evolution and association of electrophysiological abnormalities in early HIV infection and suggests a predictive value for SEP in HIV infected asymptomatic individuals. C1 HM JACKSON FDN,BETHESDA,MD. UNIFORMED SERV UNIV HLTH SCI,DEPT NEUROL,BETHESDA,MD 20814. NIMH,CLIN SCI LAB,BETHESDA,MD 20892. RP JABBARI, B (reprint author), WALTER REED ARMY MED CTR,NEUROL SERV,DIV CLIN NEUROPHYSIOL,WASHINGTON,DC 20307, USA. RI martin, alex/B-6176-2009 NR 28 TC 43 Z9 43 U1 0 U2 3 PU ELSEVIER SCI IRELAND LTD PI CLARE PA CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE, IRELAND SN 0013-4694 J9 ELECTROEN CLIN NEURO JI Electroencephalogr. Clin. Neurophysiol. PD MAR PY 1993 VL 86 IS 3 BP 145 EP 151 DI 10.1016/0013-4694(93)90001-C PG 7 WC Engineering, Biomedical; Clinical Neurology SC Engineering; Neurosciences & Neurology GA KU494 UT WOS:A1993KU49400001 PM 7680989 ER PT J AU PERLSTEIN, RS WHITNALL, MH ABRAMS, JS MOUGEY, EH NETA, R AF PERLSTEIN, RS WHITNALL, MH ABRAMS, JS MOUGEY, EH NETA, R TI SYNERGISTIC ROLES OF INTERLEUKIN-6, INTERLEUKIN-1, AND TUMOR-NECROSIS-FACTOR IN THE ADRENOCORTICOTROPIN RESPONSE TO BACTERIAL LIPOPOLYSACCHARIDE INVIVO SO ENDOCRINOLOGY LA English DT Article ID PITUITARY-CELLS-INVITRO; CORTICOTROPIN-RELEASING HORMONE; FACTOR-ALPHA; INFLAMMATORY RESPONSE; MONOCLONAL-ANTIBODIES; RECEPTOR ANTAGONIST; ADRENAL AXIS; RAT; ENDOTOXIN; SECRETION AB Administration of lipopolysaccharide (LPS) results in activation of the hypothalamic-pituitary-adrenal axis. LPS induces the release of a number of proinflammatory cytokines, i.e. interleukin-1 (IL-1), IL-6, and tumor necrosis factor (TNF), which activate the hypothalamic-pituitary-adrenal axis as well and may mediate the effects of LPS. Variations in the kinetics of appearance of IL-1, TNF, and IL-6 after LPS challenge suggested that these cytokines may play different roles at different times. To elucidate the mutual dependence and contribution of individual cytokines in the course of LPS-induced ACTH release, we used blocking antibodies to IL-6, TNF, and the IL-1 receptor. Our results demonstrate that anti-IL-6 antibody abrogated ACTH induction throughout the course of the response both 2 and 4 h after LPS challenge. In contrast, anti-IL-1 receptor and anti-TNF antibody, given individually, blocked ACTH production at 4 h, but not at 2 h. Only combined administration of these two antibodies diminished, but did not eliminate, ACTH release at 2 h. This is the first demonstration that all three inflammatory cytokines are obligatory for LPS-induced elevation of plasma ACTH. In addition, these results suggest that IL-1, IL-6, and TNF play different roles in LPS-induced ACTH release. C1 ARMED FORCES RADIOBIOL RES INST, DEPT EXPTL HEMATOL, BETHESDA, MD 20889 USA. DNAX RES INST MOLEC & CELLULAR BIOL INC, DEPT IMMUNOL, PALO ALTO, CA 94304 USA. ARMED FORCES RADIOBIOL RES INST, DEPT PHYSIOL, BETHESDA, MD 20889 USA. WALTER REED ARMY INST RES, DEPT MED NEUROSCI, NEUROENDOCRINOL & NEUROCHEM BRANCH, WASHINGTON, DC 20307 USA. NR 57 TC 217 Z9 220 U1 0 U2 1 PU ENDOCRINE SOC PI WASHINGTON PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA SN 0013-7227 EI 1945-7170 J9 ENDOCRINOLOGY JI Endocrinology PD MAR PY 1993 VL 132 IS 3 BP 946 EP 952 DI 10.1210/en.132.3.946 PG 7 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA KP290 UT WOS:A1993KP29000003 PM 8382602 ER PT J AU TESKE, ME BOWERS, JF RAFFERTY, JE BARRY, JW AF TESKE, ME BOWERS, JF RAFFERTY, JE BARRY, JW TI FSCBG - AN AERIAL SPRAY DISPERSION MODEL FOR PREDICTING THE FATE OF RELEASED MATERIAL BEHIND AIRCRAFT SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article; Proceedings Paper CT SYMP ON PESTICIDES IN FOREST MANAGEMENT, AT THE 11TH ANNUAL MEETING OF THE SOC OF ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY CY NOV 11-15, 1990 CL ARLINGTON, VA SP SOC ENVIRONM TOXICOL & CHEM DE MODELING; SPRAY BEHAVIOR; AERIAL APPLICATION; COMPUTER ID EVAPORATION; AIR AB The development of the aerial spray dispersion model FSCBG (Forest Service, Cramer, Barry and Grim) by the USDA Forest Service and the U.S. Army is reviewed. FSCBG predicts the behavior of spray material released through nozzles into the wake of a spray aircraft (helicopter or fixed-wing), traveling through idealized atmospheric effects, penetrating a canopy and depositing on the ground. FSCBG contains simplified models for the complex flow structure behind aircraft and the mechanisms that affect the fate of aerially released material: downwind drift, evaporation, canopy penetration, and ground and canopy deposition. Model development efforts encompass the areas of spray behavior, aircraft wake effects, meteorological influences, canopy interaction, and deposition. These efforts are supplemented by model validation with field tests. The ability of the model to quantify off-target spray drift is particularly important. C1 USA,DIV METEOROL,DUGWAY PROVING GROUND,UT 84022. US FOREST SERV,DAVIS,CA 95616. RP TESKE, ME (reprint author), CONTINUUM DYNAM INC,POB 3073,PRINCETON,NJ 08543, USA. NR 39 TC 59 Z9 60 U1 0 U2 6 PU SETAC PRESS PI PENSACOLA PA 1010 NORTH 12TH AVE, PENSACOLA, FL 32501-3370 SN 0730-7268 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD MAR PY 1993 VL 12 IS 3 BP 453 EP 464 DI 10.1897/1552-8618(1993)12[453:FAASDM]2.0.CO;2 PG 12 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA KQ427 UT WOS:A1993KQ42700007 ER PT J AU RAFFERTY, JE BOWERS, JF AF RAFFERTY, JE BOWERS, JF TI COMPARISON OF FSCBG SPRAY MODEL PREDICTIONS WITH FIELD-MEASUREMENTS SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article; Proceedings Paper CT SYMP ON PESTICIDES IN FOREST MANAGEMENT, AT THE 11TH ANNUAL MEETING OF THE SOC OF ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY CY NOV 11-15, 1990 CL ARLINGTON, VA SP SOC ENVIRONM TOXICOL & CHEM DE AERIAL SPRAY RELEASES; AIRCRAFT WAKE; CANOPY PENETRATION; DEPOSITION MODEL; DISPERSION MODEL ID AMS WORKSHOP; WOODS-HOLE AB The FSCBG (Forest Service, Cramer, Barry, and Grim) aerial spray model was developed under joint sponsorship of the U.S. Army and the USDA Forest Service to predict concentration, dosage, and deposition patterns of spray material downwind from aerial releases. A new version of the model incorporates the AGDISP model, which provides a much more rigorous mathematical description of wake effects on drop trajectories than the simple wake effects algorithm of the original FSCBG model. This paper describes graphical and statistical comparisons of deposition measurements from two field programs with model predictions using (a) no wake effects, (b) the simple wake effects of the original model, and (c) the AGDISP (agricultural dispersal) wake effects of the new model. All model versions showed skill in reproducing observed deposition profiles for both data sets. The inclusion of complex wake effects qualitatively improved the correspondence between predictions and measurements in the vicinity of the peak deposition for inwind releases and at the longer downwind distances for crosswind releases. However, statistical performance measures were inconclusive in quantifying this improvement. RP RAFFERTY, JE (reprint author), USA,DIV METEOROL,DUGWAY PROVING GROUND,UT 84022, USA. NR 15 TC 7 Z9 7 U1 0 U2 0 PU SETAC PRESS PI PENSACOLA PA 1010 NORTH 12TH AVE, PENSACOLA, FL 32501-3370 SN 0730-7268 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD MAR PY 1993 VL 12 IS 3 BP 465 EP 480 DI 10.1897/1552-8618(1993)12[465:COFSMP]2.0.CO;2 PG 16 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA KQ427 UT WOS:A1993KQ42700008 ER PT J AU DILLON, TM MOORE, DW GIBSON, AB AF DILLON, TM MOORE, DW GIBSON, AB TI DEVELOPMENT OF A CHRONIC SUBLETHAL BIOASSAY FOR EVALUATING CONTAMINATED SEDIMENT WITH THE MARINE POLYCHAETE WORM NEREIS-(NEANTHES)-ARENACEODENTATA SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Article DE CHRONIC; SUBLETHAL; GROWTH; SEDIMENT; NEANTHES ID NEANTHES-ARENACEODENTATA POLYCHAETA; SULFIDE DETOXIFICATION; RIFTIA-PACHYPTILA; REPRODUCTION; CHEMISTRY; MEIOFAUNA; TOXICITY; AMMONIA; GROWTH; WATERS AB Development of a chronic sublethal sediment bioassay with the polychaete Nereis (Neanthes) arenaceodentata is described. The sublethal test end point was estimated individual somatic growth rate (milligrams dry weight per day). The test was initiated with two- to three-week-old post-emergent juvenile worms and continued for 28 d. The potential bias due to selected nontreatment factors on polychaete survival and growth was evaluated. For example, grain size had no significant effect, whereas the number of worms placed in each exposure vessel was critical. Direct transfer from 30 parts per thousand seawater to salinites less-than-or-equal-to 15 parts per thousand had a highly significant and adverse effect on survival and growth. Both survival and growth of juvenile worms may be adversely affected if test conditions involve exposures to greater than or equal to 0.7 mg/L un-ionized ammonia or greater than or equal to 5 mg/L hydrogen sulfide. Survival of juvenile worms to concentrations of the reference toxicant, cadmium chloride, approximating the 96-h LC50 (5 mg/L) was used as a quality control measure. Results are expressed in control chart format analogous to methods used in analytical chemistry. RP DILLON, TM (reprint author), USA,ENGINEER WATERWAYS EXPT STN,CEWES ES R,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 65 TC 48 Z9 49 U1 1 U2 1 PU SETAC PRESS PI PENSACOLA PA 1010 NORTH 12TH AVE, PENSACOLA, FL 32501-3370 SN 0730-7268 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PD MAR PY 1993 VL 12 IS 3 BP 589 EP 605 DI 10.1897/1552-8618(1993)12[589:DOACSB]2.0.CO;2 PG 17 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA KQ427 UT WOS:A1993KQ42700018 ER PT J AU NONCLERCQ, D TOUBEAU, G LAURENT, G SCHAUDIES, RP ZANEN, J HEUSONSTIENNON, JA AF NONCLERCQ, D TOUBEAU, G LAURENT, G SCHAUDIES, RP ZANEN, J HEUSONSTIENNON, JA TI IMMUNOCYTOLOGICAL LOCALIZATION OF EPIDERMAL GROWTH-FACTOR IN THE RAT-KIDNEY AFTER DRUG-INDUCED TUBULAR INJURY SO EUROPEAN JOURNAL OF MORPHOLOGY LA English DT Article; Proceedings Paper CT JOINT MEETING OF THE DUTCH AND BELGIAN SOCIETIES FOR ELECTRON MICROSCOPY AND THE BELGIAN SOC FOR CELL BIOLOGY : BIOMEDICAL COMMUNICATIONS CY DEC 10-11, 1992 CL ANTWERP, BELGIUM SP DUTCH SOC ELECTRON MICROSCOPY, BELGIAN SOC ELECTRON MICROSCOPY, BELGIUM SOC CELL BIOL DE EPIDERMAL GROWTH FACTOR; EGF; TUBULAR REGENERATION; NEPHROTOXICITY ID TISSUE-REPAIR; CELLS; MOUSE; EGF AB The present study was undertaken to analyze, at the cytological level, the intrarenal distribution of epidermal growth factor (EGF) in normal conditions and after drug-induced tubular injury. Female Sprague-Dawley rats were injected with gentamicin (50 mg/kg.day) for 4 days to induce tubular necrosis and were terminated 4 days after the last drug administration. For light microscopy, EGF immunoreactivity was demonstrated by immunogold-silver staining. In the kidneys of control rats EGF was found associated with distal tubules (cortex and outer medulla). Kidney exposure to gentamicin resulted in a drastic decrease of EGF immunoreactivity. For the electron microscopy study, immunoreactive EGF was detected on ultrathin sections by immunogold labeling. Within distal tubules epithelium of control animals, immunoreactive material was predominantly seen on the basolateral membrane, and to a much lesser extent in the cytoplasm or on the apical membrane. After treatment with gentamicin, there was a reduction of the density of gold particles observed in distal tubule cells. Interestingly, gold particles also appeared, but at a lower density, in proximal tubule cells. In these cells, EGF immunoreactivity also seemed membrane-bound and was mostly observed on (or next to) the basolateral membrane. C1 WALTER REED ARMY INST RES,DEPT NEPHROL,WASHINGTON,DC 20307. RP NONCLERCQ, D (reprint author), UNIV MONS HAINAUT,FAC MED,SERV HISTOL,AVE CHAMP MARS 24,B-7000 MONS,BELGIUM. RI Laurent, Guy/B-6278-2009; Nonclercq, Denis/B-6455-2009 NR 22 TC 3 Z9 3 U1 0 U2 0 PU SWETS ZEITLINGER PUBLISHERS PI LISSE PA P O BOX 825, 2160 SZ LISSE, NETHERLANDS SN 0924-3860 J9 EUR J MORPHOL JI Eur. J. Morphol. PD MAR-JUN PY 1993 VL 31 IS 1-2 BP 65 EP 71 PG 7 WC Anatomy & Morphology SC Anatomy & Morphology GA LQ289 UT WOS:A1993LQ28900014 PM 8398562 ER PT J AU WARBURG, A SCHNEIDER, I AF WARBURG, A SCHNEIDER, I TI INVITRO CULTURE OF THE MOSQUITO STAGES OF PLASMODIUM-FALCIPARUM SO EXPERIMENTAL PARASITOLOGY LA English DT Article DE BASEMENT MEMBRANE; MATRIGEL; OOCYSTS; OOKINETES; PLASMODIUM-FALCIPARUM; PLASMODIUM-GALLINACEUM; SPOROGONY; SPOROZOITES ID MALARIA PARASITES; DROSOPHILA C1 WALTER REED ARMY INST RES,DEPT ENTOMOL,WASHINGTON,DC 20307. RP WARBURG, A (reprint author), NIAID,MALARIA RES LAB,BLDG 4,ROOM 126,BETHESDA,MD 20892, USA. NR 21 TC 33 Z9 34 U1 0 U2 3 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0014-4894 J9 EXP PARASITOL JI Exp. Parasitol. PD MAR PY 1993 VL 76 IS 2 BP 121 EP 126 DI 10.1006/expr.1993.1014 PG 6 WC Parasitology SC Parasitology GA KU483 UT WOS:A1993KU48300003 PM 8454020 ER PT J AU KADAKIA, S CASSADAY, M SHAFFER, R AF KADAKIA, S CASSADAY, M SHAFFER, R TI COMPARISON OF FOLEY CATHETER AS A REPLACEMENT GASTROSTOMY TUBE WITH COMMERCIAL GASTROSTOMY TUBE - A PROSPECTIVE RANDOMIZED TRIAL SO GASTROINTESTINAL ENDOSCOPY LA English DT Meeting Abstract C1 BROOKE ARMY MED CTR,DEPT MED,GASTROENTEROL SECT,FT SAM HOUSTON,TX 78234. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0016-5107 J9 GASTROINTEST ENDOSC JI Gastrointest. Endosc. PD MAR-APR PY 1993 VL 39 IS 2 BP 252 EP 252 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA LA057 UT WOS:A1993LA05700060 ER PT J AU KADAKIA, S ANGUEIRA, C MOORE, M AF KADAKIA, S ANGUEIRA, C MOORE, M TI ANTICOAGULATION AND ENDOSCOPY - PRELIMINARY-RESULTS OF A SURVEY OF ASGE MEMBERS SO GASTROINTESTINAL ENDOSCOPY LA English DT Meeting Abstract C1 BROOKE ARMY MED CTR,DEPT MED & HOSP ADM SERV,GASTROENTEROL SERV,FT SAM HOUSTON,TX 78234. NR 0 TC 1 Z9 1 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0016-5107 J9 GASTROINTEST ENDOSC JI Gastrointest. Endosc. PD MAR-APR PY 1993 VL 39 IS 2 BP 266 EP 266 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA LA057 UT WOS:A1993LA05700118 ER PT J AU CARROUGHER, JG BOWEN, K SHAFFER, RT KADAKIA, S AF CARROUGHER, JG BOWEN, K SHAFFER, RT KADAKIA, S TI THE PREVALENCE OF COLONIC NEOPLASMS IN PATIENTS WITH BREAST-CARCINOMA SO GASTROINTESTINAL ENDOSCOPY LA English DT Meeting Abstract C1 BROOKE ARMY MED CTR,DEPT MED,GASTROENTEROL SERV,FT SAM HOUSTON,TX 78234. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0016-5107 J9 GASTROINTEST ENDOSC JI Gastrointest. Endosc. PD MAR-APR PY 1993 VL 39 IS 2 BP 294 EP 294 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA LA057 UT WOS:A1993LA05700226 ER PT J AU BUTLER, DK KEAN, TB AF BUTLER, DK KEAN, TB TI INVESTIGATIONS OF MAGNETIC-FIELD DISTURBANCES AT AN AIR-FORCE BASE COMPASS CALIBRATION HARDSTAND SO GEOPHYSICS LA English DT Article AB Investigations were conducted to determine the nature and cause of magnetic field disturbances at the calibration hardstand (compass rose) at an air force base. The disturbances have prevented the normal and routine use of the hardstand since its construction in the mid-1950s, with heightened concern over the problem every 10-12 years. The investigations included the characterization of the horizontal, vertical, and temporal variation of the total magnetic field strength both on and off the hardstand. On the hardstand, the field varies by as much as 1,000 nT over 10 m horizontally and by as much as 600 nT over 2.5 m vertically. Also, on the hardstand, the magnetic field varies extremely erratically with time by 50-60 nT over periods of a few seconds. Off the hardstand, the magnetic field is extremely stable. and varies by less than 10 nT over 10 m horizontally, 2.5 m vertically, and over periods of 10-15 min. The magnetic field ''stabilizes'' at distances less than 10 m horizontally from the edge of the hardstand. Both on and off the hardstand, the magnetic field variations are independent of the status (on or off) of a nearby instrument landing system (ILS) (approach radar). The results of the magnetic field characterization indicate that the cause of the problem is the hardstand itself. The hardstand concrete was found to have a large bulk magnetic susceptibility, and the concrete aggregate has a permanent magnetization sufficiently large to visibly deflect a compass needle; these factors, coupled with a correlation with the 11-year solar cycle, suffice to explain the magnetic ''disturbances'' at the hardstand. RP BUTLER, DK (reprint author), USA,ENGINEER WATERWAYS EXPT STN,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC EXPLORATION GEOPHYSICISTS PI TULSA PA 8801 S YALE ST, TULSA, OK 74137 SN 0016-8033 J9 GEOPHYSICS JI Geophysics PD MAR PY 1993 VL 58 IS 3 BP 434 EP 440 DI 10.1190/1.1443427 PG 7 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA KR108 UT WOS:A1993KR10800012 ER PT J AU SJOGREN, MH AF SJOGREN, MH TI ACUTE HEPATITIS-A - AN ENDANGERED SPECIES SO HEPATOLOGY LA English DT Note RP SJOGREN, MH (reprint author), USA,MED RES,INST INFECT DIS,FT DETRICK,FREDERICK,MD 21702, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0270-9139 J9 HEPATOLOGY JI Hepatology PD MAR PY 1993 VL 17 IS 3 BP 519 EP 520 PG 2 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA KR609 UT WOS:A1993KR60900024 PM 8444426 ER PT J AU WEINSTEIN, SA SMITH, LA AF WEINSTEIN, SA SMITH, LA TI CHROMATOGRAPHIC PROFILES AND PROPERTIES OF DUVERNOY SECRETIONS FROM SOME BOIGINE AND DISPHOLIDINE COLUBRIDS SO HERPETOLOGICA LA English DT Article DE COLUBRIDAE; BOIGINAE; DISPHOLIDINAE; DUVERNOY SECRETIONS; LETHAL POTENCIES; CHROMATOGRAPHIC PROFILES; IMMUNOIDENTITY ID BROWN TREE SNAKE; BIOCHEMICAL PROPERTIES; VENOM; IRREGULARIS; HEMORRHAGIN; PRINCIPLE; SERPENTES; TOXINS; BITES; GLAND AB Duvernoy's secretion was collected from five species of opisthoglyphous colubrids. Large yields were obtained from Boiga dendrophila melanota. Specimens of B. d. multicincta and a large adult specimen of B. blandingi produced large volumes of secretion with low content of solids. Lethal potency determinations showed that samples of secretions from the dispholidines, Thelotornis capensis and Dispholidus typus, were the most toxic, while B. d. multicincta and the large adult B. blandingi had the lowest lethal potency of the species studied. Assay of hemorrhagic and proteolytic activities revealed that secretion from a specimen of B. blandingi from Ghana had the highest level of these activities of any boigine sample examined. Both dispholidine samples had far greater protease and hemorrhagin activities than any boigine sample studied. Polyacrylamide gel electrophoresis indicated that Thelotomis and Dispholidus had relatively complex patterns which differed from each other and the boigine samples. Secretions from B. blandingi and both races of B, dendrophila share major components in the 10,000-14,000 molecular weight range, It is not clear if these are identical proteins or different components with similar molecular weight. Cation exchange analysis resolved one, two, and three toxic fractions from secretions of B. d. melanota, B. blandingi, and D. typus, respectively. The fractions from B. d. melanota and two of the fractions from D. typus were proteolytic and hemorrhagic, while the fractions from B. blandingi produced symptoms suggestive of a postsynaptic neurotoxin. Immunodiffusion indicated immunoidentity between components of most of the secretions studied and venoms of the bungarine elapids, Ophiophagus hannah and Bungarus multicinctus. Little identity was seen with the elapine elapid, Micrurus fulvius fulvius. Some reactivity was observed with antiserum against the crotaline viperid, Crotalus horridus; however no identity with venom type A of C. scutulatus was noted. Components of several of the lethal pools obtained from cation exchange showed identity with the elapid antisera and minor reactivity with antiserum against venom of the viperine viperid, Echis coloratus. RP WEINSTEIN, SA (reprint author), USA,MED RES INST,DEPT TOXINOL,DIV PATHOPHYSIOL,FT DETRICK,MD 21702, USA. NR 55 TC 16 Z9 17 U1 0 U2 0 PU HERPETOLOGISTS LEAGUE PI JOHNSON CITY PA EAST TENNESSEE STATE UNIV, DEPT BIOLOGICAL SCIENCES, BOX 70726, JOHNSON CITY, TN 37614-0726 SN 0018-0831 J9 HERPETOLOGICA JI Herpetologica PD MAR PY 1993 VL 49 IS 1 BP 78 EP 94 PG 17 WC Zoology SC Zoology GA KQ018 UT WOS:A1993KQ01800008 ER PT J AU ZHAO, JH LIS, R COBLENTZ, D ILLAN, J MCAFEE, S BURKE, T WEINER, M BUCHWALD, W JONES, KA AF ZHAO, JH LIS, R COBLENTZ, D ILLAN, J MCAFEE, S BURKE, T WEINER, M BUCHWALD, W JONES, KA TI AN INP-BASED OPTOTHYRISTOR FOR PULSED POWER-SWITCHING APPLICATIONS SO IEEE ELECTRON DEVICE LETTERS LA English DT Article AB A high-power InP-based optothyristor has been fabricated and tested for pulsed power switching. To increase the power handling capability, the device has a 250-mum-thick Fe-doped semi-insulating (SI) InP sandwiched between two p-n junctions grown by MOCVD. The device turn-on is controlled by optical illumination on the SI-InP, which creates a high concentration of electron and hole pairs. The switched current and the di/dt rating have been studied as a function of the switch blocking voltage. It is shown that the optothyristor is capable of switching a current almost four times the current switched by a bulk SI-InP photoconductive switch under the same voltage bias. C1 USA,LABCOM,ETD LAB,FT MONMOUTH,NJ 07703. AT&T BELL LABS,MURRAY HILL,NJ 07974. RP ZHAO, JH (reprint author), RUTGERS STATE UNIV,DEPT ELECT & COMP ENGN,PISCATAWAY,NJ 08855, USA. NR 6 TC 1 Z9 1 U1 1 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0741-3106 J9 IEEE ELECTR DEVICE L JI IEEE Electron Device Lett. PD MAR PY 1993 VL 14 IS 3 BP 140 EP 142 DI 10.1109/55.215137 PG 3 WC Engineering, Electrical & Electronic SC Engineering GA KN764 UT WOS:A1993KN76400015 ER PT J AU KHALED, EEM HILL, SC BARBER, PW AF KHALED, EEM HILL, SC BARBER, PW TI SCATTERED AND INTERNAL INTENSITY OF A SPHERE ILLUMINATED WITH A GAUSSIAN-BEAM SO IEEE TRANSACTIONS ON ANTENNAS AND PROPAGATION LA English DT Article ID LORENZ-MIE THEORY; FOCUSED LASER-BEAM; LOCALIZED APPROXIMATION; LIGHT-SCATTERING; PARTICLE; FIELDS; COEFFICIENTS AB A method of calculating the internal and scattered electric fields of a spherical dielectric object illuminated with a Gaussian beam is presented. The vector nature of the beam is considered. The fields satisfy Maxwell's equations, and the beam can be located arbitrarily with respect to the object. A polarized Gaussian beam is first represented as an angular spectrum of plane waves. These waves are then expanded in vector spherical harmonics. Although the details of the expansion are presented for a lowest-order Gaussian beam, the method can be applied to any wave which can be expressed as a sum of homogeneous plane waves. The interaction of an arbitrarily located Gaussian beam with a spherical object is analyzed using the T-matrix method. Calculated results for beams having waists much smaller than the radius of the sphere help in visualizing how a narrow beam reflects and refracts at the spherical dielectric interfaces. The combination of the plane-wave spectrum technique and the T-matrix method can be applied to the problem of an arbitrary beam interacting with an axisymmetric, nonspherical, homogeneous or layered object. C1 USA,ATMOSPHER SCI LAB,WHITE SANDS MISSILE RANGE,NM 88002. NEW MEXICO STATE UNIV,DEPT ELECT & COMP ENGN,LAS CRUCES,NM 88003. RP KHALED, EEM (reprint author), CLARKSON UNIV,DEPT ELECT & COMP ENGN,POTSDAM,NY 13699, USA. NR 32 TC 50 Z9 50 U1 0 U2 2 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-926X J9 IEEE T ANTENN PROPAG JI IEEE Trans. Antennas Propag. PD MAR PY 1993 VL 41 IS 3 BP 295 EP 303 DI 10.1109/8.233134 PG 9 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA LH043 UT WOS:A1993LH04300006 ER PT J AU STRICKLAND, BR AUDEH, NF AF STRICKLAND, BR AUDEH, NF TI DIODE-LOADED DIPOLE ANTENNA MODELING AND DESIGN SO IEEE TRANSACTIONS ON ANTENNAS AND PROPAGATION LA English DT Article AB A circuit model for a diode-loaded dipole electric field measurement probe is presented which is valid for frequencies below 10 GHz. Assumptions are made to allow linear analysis based on the Laplace transform method. Optimized design criteria for the probe are then developed, with the major considerations being large bandwidth, independence of temperature, and maximum output. Experimental measurements on a probe designed for operation between 1 and 1000 MHz and comparison with the theoretical results are presented. C1 UNIV ALABAMA,DEPT ELECT & COMP ENGN,HUNTSVILLE,AL 35899. RP STRICKLAND, BR (reprint author), USA,STRATEG DEF COMMAND,HUNTSVILLE,AL, USA. NR 5 TC 6 Z9 6 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-926X J9 IEEE T ANTENN PROPAG JI IEEE Trans. Antennas Propag. PD MAR PY 1993 VL 41 IS 3 BP 333 EP 337 DI 10.1109/8.233130 PG 5 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA LH043 UT WOS:A1993LH04300010 ER PT J AU Tidrow, SC Wilber, WD Tidrow, MZ AF Tidrow, S. C. Wilber, W. D. Tidrow, M. Zhu TI LASER ABLATION OF YBCO: UTILIZING O-18 TO INVESTIGATE THE INCORPORATION OF OXYGEN INTO THE LASER PLUME SO IEEE TRANSACTIONS ON APPLIED SUPERCONDUCTIVITY LA English DT Article AB By understanding the behavior of oxygen in the deposition and processing of high T-c superconducting films and multilayers, the quality of high T-c superconducting single and multilayer film devices can be improved. The tracer O-18 provides a powerful tool for investigating the behavior of oxygen in film deposition and processing. Here, we report the first investigation where O-18 is used as a tracer to measure the transfer of oxygen from the chamber atmosphere into the laser induced plume. The amount of oxygen incorporated into the plume was found by laser ablating from a polycrystalline YBCO target onto a room temperature carbon substrate in an atmosphere of 50% O-16 and 50% O-18. A series of such samples were prepared using deposition pressures ranging from 0.5 to 260 mTorr. The film stoichiometry including, most importantly, the atomic fraction of O-18, for each sample was determined using Rutherford backscattering. Our results show that the incorporation of O-18 from the deposition atmosphere increases with increasing deposition pressure (50% O-16 and 50% O-18) up to approximately 25 mTorr and then, unexpectedly, decreases for higher pressures. C1 [Tidrow, S. C.; Wilber, W. D.; Tidrow, M. Zhu] US Army Res Lab, Elect & Power Sources Directorate, Attent AMSRL EP EC H, Ft Monmouth, NJ 07703 USA. RP Tidrow, SC (reprint author), Natl Res Council ETDL Res Associate, Toronto, ON, Canada. NR 13 TC 3 Z9 3 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1051-8223 EI 1558-2515 J9 IEEE T APPL SUPERCON JI IEEE Trans. Appl. Supercond. PD MAR PY 1993 VL 3 IS 1 BP 1078 EP 1081 DI 10.1109/77.233888 PN 3 PG 4 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA V43TH UT WOS:000209703200043 ER PT J AU KOSINSKI, JA BALLATO, A LU, YC AF KOSINSKI, JA BALLATO, A LU, YC TI MEASURED PROPERTIES OF DOUBLY ROTATED DILITHIUM TETRABORATE (LI2B4O7) RESONATORS AND TRANSDUCERS SO IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL LA English DT Article ID SOL-GEL METHOD; FILMS AB Calculations of the properties expected for doubly-rotated dilithium tetraborate resonators and transducers have been presented recently. A set of dilithium tetraborate plates, cut to the nominal angles of cut of (YXwl)40-degrees/33-degrees (TA-cut) and (YXwl)19-degrees/56-degrees (TC-cut) have been supplied by a crystal grower, and have been processed into plate resonators. The mode spectra and electrical circuit parameters of the resonators have been examined for the fundamental, third, and fifth harmonics for all three thickness modes of the resonators. The observed values of frequency constants and piezoelectric coupling are in good agreement with the predicted values. The frequency-temperature behavior of the zero-temperature coefficient cuts has also been measured. These data are less well in agreement with the predicted values. C1 RUTGERS UNIV,DEPT ELECT & COMP ENGN,PISCATAWAY,NJ 08855. RP KOSINSKI, JA (reprint author), USA,RES LAB,LABCOM ELECTR & POWER SOURCES DIRECTORATE,FT MONMOUTH,NJ 07703, USA. NR 16 TC 2 Z9 2 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0885-3010 J9 IEEE T ULTRASON FERR JI IEEE Trans. Ultrason. Ferroelectr. Freq. Control PD MAR PY 1993 VL 40 IS 2 BP 154 EP 161 DI 10.1109/58.212564 PG 8 WC Acoustics; Engineering, Electrical & Electronic SC Acoustics; Engineering GA LA510 UT WOS:A1993LA51000009 PM 18263169 ER PT J AU ELKINS, KL RHINEHARTJONES, T NACY, CA WINEGAR, RK FORTIER, AH AF ELKINS, KL RHINEHARTJONES, T NACY, CA WINEGAR, RK FORTIER, AH TI T-CELL-INDEPENDENT RESISTANCE TO INFECTION AND GENERATION OF IMMUNITY TO FRANCISELLA-TULARENSIS SO INFECTION AND IMMUNITY LA English DT Article ID SALMONELLA-TYPHIMURIUM INFECTION; TUMOR-NECROSIS-FACTOR; ATHYMIC NUDE-MICE; GAMMA-DELTA; INTRAEPITHELIAL LYMPHOCYTES; LISTERIA-MONOCYTOGENES; MYCOBACTERIUM-TUBERCULOSIS; MACROPHAGE ACTIVATION; MONOCLONAL-ANTIBODIES; RECEPTOR EXPRESSION AB The intraperitoneal 50% lethal dose (LD50) for Francisella tularensis LVS in both normal control heterozygote BALB/c nul+ mice and BALB/c nu/nu mice was 2 x 10(0). Both nu/+ and nu/nu mice given 10(7) LVS bacteria or more intradermally (i.d.) died, with a mean time to death of about 7 to 8 days. On the other hand, nu/+ mice given 10(6) LVS bacteria or less survived for more than 60 days and cleared systemic bacteria, while nu/nu mice given 10(6) LVS bacteria or less survived for more than 10 days but died between days 25 and 30. Thus, the short-term (i.e., < 10-day) i.d. LD50 of both nu/nu and nu/+ mice was 3 x 10(6), but the long-term (i.e., >10-day) i.d. LD50 of nu/nu mice was less than 7 x 10(0). The short-term survival of i.d. infection was dependent on tumor necrosis factor and gamma interferon: treatment of nu/nu mice with anti-tumor necrosis factor or anti-gamma interferon at the time of i.d. infection resulted in death from infection 7 to 8 days later, whereas control infected nu/nu mice survived for 26 days. nu/nu mice infected with LVS i.d. generated LVS-specific serum antibodies, which were predominantly immunoglobulin M: titers peaked 7 days after i.d. infection but declined sharply by day 21, after which mice died. Surprisingly, nu/nu mice given 10(3) LVS bacteria i.d. became resistant to a lethal challenge (5,000 LD50s) of LVS intraperitoneally within 2 days after i.d. infection; nu/nu mice similarly infected with LVS i.d. and challenged with Salmonella typhimurium (10 LD50s) were not protected. nu/nu mice given nu/+ spleen cells intravenously as a source of mature T cells survived i.d. infection for more than 60 days and cleared bacteria. Taken together, these studies demonstrate that i.d. infection of nu/nu mice with LVS rapidly generates T-cell-independent, short-term, specific protective immunity against lethal challenge, but T lymphocytes are essential for long-term survival. RP ELKINS, KL (reprint author), WALTER REED ARMY INST RES,DEPT CELLULAR IMMUNOL,SUITE 200,9620 MED CTR DR,ROCKVILLE,MD 20850, USA. NR 42 TC 71 Z9 72 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD MAR PY 1993 VL 61 IS 3 BP 823 EP 829 PG 7 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA KN097 UT WOS:A1993KN09700005 PM 8432603 ER PT J AU SCHIFF, DE WASS, CA CRYZ, SJ CROSS, AS KIM, KS AF SCHIFF, DE WASS, CA CRYZ, SJ CROSS, AS KIM, KS TI ESTIMATION OF PROTECTIVE LEVELS OF ANTI-O-SPECIFIC LIPOPOLYSACCHARIDE IMMUNOGLOBULIN-G ANTIBODY AGAINST EXPERIMENTAL ESCHERICHIA-COLI INFECTION SO INFECTION AND IMMUNITY LA English DT Article ID INFLUENZAE TYPE-B; CONJUGATE VACCINES; K1 CAPSULE; BACTEREMIA; HUMANS; IMMUNOGENICITY; MORTALITY; GLOBULIN; DISEASE; SAFETY AB Serum obtained after immunization with an 018 polysaccharide-toxin A conjugate vaccine was evaluated for the estimation of protective levels of anti-O-specific lipopolysaccharide (LPS) immunoglobulin G (IgG) antibody against bacteremia and death caused by a homologous serotype of Escherichia coli K1 strains. Passive transfer of rabbit serum conferred significant protection from a lethal E. coli infection in a neonatal rat model. The overall incidence of bacteremia and mortality was 4% in rat pups receiving undiluted postvaccination serum, while that in control animals was 100% (P < 0.001). The overall incidences of bacteremia were 5 and 72% for animals with serum anti-018 LPS IgG concentrations of > 1.0 and < 1.0 mug/ml, respectively, while the overall incidences of mortality for animals with serum anti-018 LPS IgG levels of > 1.0 and < 1.0 mug/ml were 0 and 72%, respectively (P < 0.001). Protection against E. coli infection was also demonstrated with human anti-018 polysaccharide IgG. None of the animals with human anti-018 LPS IgG levels of > 1 mug/ml had bacteremia after bacterial challenge, whereas all animals with bacteremia at 18 h had levels of < 1 mug/ml. These findings suggest that serum anti-018 LPS IgG concentrations of > 1.0 mug/ml may provide protection against bacteremia and death caused by a homologous E. coli K1 infection. C1 SWISS SERUM & VACCINE INST,BERN,SWITZERLAND. WALTER REED ARMY INST RES,DEPT BACTERIAL DIS,WASHINGTON,DC 20307. RP KIM, KS (reprint author), CHILDRENS HOSP,LOS ANGELES,CA 90027, USA. FU NINDS NIH HHS [R01-NS-26310] NR 25 TC 19 Z9 19 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD MAR PY 1993 VL 61 IS 3 BP 975 EP 980 PG 6 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA KN097 UT WOS:A1993KN09700026 PM 7679376 ER PT J AU ARTENSTEIN, AW POROPATICH, RK ROWE, JE AF ARTENSTEIN, AW POROPATICH, RK ROWE, JE TI CRYPTOCOCCAL DISEASE PRESENTING AS A CUTANEOUS LESION IN A PATIENT WITH SARCOIDOSIS SO INFECTIOUS DISEASES IN CLINICAL PRACTICE LA English DT Article C1 WALTER REED ARMY MED CTR,INFECT DIS SERV,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,PULM DIS SERV,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,SERV DERMATOL,WASHINGTON,DC 20307. NR 11 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 1056-9103 J9 INFECT DIS CLIN PRAC JI Infect. Dis. Clin. Pract. PD MAR-APR PY 1993 VL 2 IS 2 BP 116 EP 118 PG 3 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA MF194 UT WOS:A1993MF19400006 ER PT J AU ROBB, MP PSAK, JL PANGCHING, GK AF ROBB, MP PSAK, JL PANGCHING, GK TI CHRONIC OTITIS-MEDIA AND EARLY SPEECH DEVELOPMENT - A CASE-STUDY SO INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY LA English DT Article DE DEVELOPMENT; HEARING; INFANTS; OTITIS MEDIA; PHONETICS; SPEECH ID PHONETIC DEVELOPMENT; ETHOLOGIC MODEL; EARLY-CHILDHOOD; VOCALIZATIONS; LANGUAGE; CHILDREN; LIFE; EFFUSION; INFANTS AB A case study of the speech development in a male infant with chronic otitis media is reported. The phonetic behavior characterizing the child's vocalizations was sampled monthly between the ages of 11 and 21 months, as he progressed from pre-speech to early speech periods of language development. Results of monthly phonetic inventory analyses indicated age-appropriate types of consonants in his pre-word and later-word vocalizations. However, the child's repertoire of consonants was considerably reduced as he first began to produce meaningful speech. Results of phonetic diversity analyses revealed an overall lack of phonetic complexity in his vocalizations throughout the course of study. In general, the child's early sound productions were characteristic of developmental delay, closely resembling the speech patterns found among severely hearing-impaired children. Findings are discussed with respect to the probable influence of chronic otitis media with effusion on a child's eventual speech development. C1 KAPIOLANI MED CTR WOMEN & CHILDREN,HONOLULU,HI. USA,MED SERV CORPS,BAYNE JONES ARMY COMMUNITY HOSP,AUDIOL SECT,FT POLK,LA. RP ROBB, MP (reprint author), UNIV HAWAII,JOHN A BURNS SCH MED,DIV SPEECH PATHOL & AUDIOL,1410 LOWER CAMPUS DR,HONOLULU,HI 96822, USA. NR 32 TC 7 Z9 7 U1 0 U2 3 PU ELSEVIER SCI IRELAND LTD PI CLARE PA CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE, IRELAND SN 0165-5876 J9 INT J PEDIATR OTORHI JI Int. J. Pediatr. Otorhinolaryngol. PD MAR PY 1993 VL 26 IS 2 BP 117 EP 127 DI 10.1016/0165-5876(93)90017-W PG 11 WC Otorhinolaryngology; Pediatrics SC Otorhinolaryngology; Pediatrics GA KP241 UT WOS:A1993KP24100003 PM 8444554 ER PT J AU WHITE, WL FERRY, JA AF WHITE, WL FERRY, JA TI APPLICATION OF GENOTYPIC ANALYSIS IN ORBITAL LYMPHOID DISEASE SO INTERNATIONAL OPHTHALMOLOGY CLINICS LA English DT Article RP WHITE, WL (reprint author), BROOKE ARMY MED CTR,DEPT SURG,SERV OPHTHALMOL,BEACH PAVIL,FT SAM HOUSTON,TX 78234, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LITTLE BROWN CO PI BOSTON PA 34 BEACON STREET, BOSTON, MA 02108-1493 SN 0020-8167 J9 INT OPHTHALMOL CLIN JI Int. Ophthalmol. Clin. PD SPR PY 1993 VL 33 IS 2 BP 49 EP 56 DI 10.1097/00004397-199303320-00005 PG 8 WC Ophthalmology SC Ophthalmology GA LF406 UT WOS:A1993LF40600004 PM 8325742 ER PT J AU ASCHER, DP ROBERTS, C AF ASCHER, DP ROBERTS, C TI DETERMINATION OF THE ETIOLOGY OF SEROREVERSALS IN HIV TESTING BY ANTIBODY FINGERPRINTING SO JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY LA English DT Article DE HIV ANTIBODIES; AUTOANTIBODIES; SEROREVERSALS ID INFECTION AB Fifteen sets of seroreversal serum samples (i.e., an initial specimen confirmed as anti-human immunodeficiency virus, HIV, positive and a 2-4-week follow-up specimen that is anti-HIV negative) were identified from 711,684 military members tested by the U.S. Army HIV screening program from January 1990 to May 1991. We utilized the Miragen Antibody Finger-printing Assay to determine what proportion of these seroreversals was caused by different or discordant patient samples as opposed to laboratory testing errors. Forty-two percent of these seroreversals demonstrated substantially discordant immunoblot strips representing serum samples from different patients. We recommend utilization of this antibody fingerprinting assay to help determine the etiology of HIV seroreversal specimens. C1 WALTER REED ARMY INST RES,DIV DIAGNOST RETROVIROL,WASHINGTON,DC 20307. RP ASCHER, DP (reprint author), WILFORD HALL USAF MED CTR,DPT PEDIATR SGHP,LACKLAND AFB,TX 78236, USA. NR 9 TC 31 Z9 32 U1 1 U2 1 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 1077-9450 J9 J ACQ IMMUN DEF SYND JI J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. PD MAR PY 1993 VL 6 IS 3 BP 241 EP 244 PG 4 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA KN542 UT WOS:A1993KN54200005 PM 8450398 ER PT J AU FERNANDO, JC ROGERS, KR ANIS, NA VALDES, JJ THOMPSON, RG ELDEFRAWI, AT ELDEFRAWI, ME AF FERNANDO, JC ROGERS, KR ANIS, NA VALDES, JJ THOMPSON, RG ELDEFRAWI, AT ELDEFRAWI, ME TI RAPID DETECTION OF ANTICHOLINESTERASE INSECTICIDES BY A REUSABLE LIGHT ADDRESSABLE POTENTIOMETRIC BIOSENSOR SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY LA English DT Article ID PESTICIDES; SENSOR; ACETYLCHOLINESTERASE; ELECTRODE AB A light addressable potentiometric sensor (LAPS) was used to detect organophosphate and carbamate anticholinesterases (anti-ChEs), using eel acetylcholinesterase (AChE) as the biological sensing element. Biotinylated AChE was preincubated with inhibitor or buffer alone and then captured on biotinylated nitrocellulose membrane via streptavidin cross-linking, or AChE was preimmobilized on the capture membrane and then a sample containing the anti-ChE was filtered through the capture membrane. Hydrolysis of acetylcholine (ACh) by the captured AChE resulted in a strong potentiometric signal, and the immobilized AChE retained its affinity for ACh and anti-ChEs. IC50 values for inhibition of captured AChE obtained by the LAPS agreed with those obtained by a spectrophotometric method or a fiber optic evanescent fluorosensor. Paraoxon and bendiocarb were detected at 10 nM, while higher concentrations were required for monocrotophos, dicrotophos, dichlorvos, phosdrin, diazinon, tetraethyl pyrophosphate, aldicarb, and methomyl. Important features of the LAPS for detection of anti-ChEs are speed (eight samples assayed simultaneously in minutes), precision, and reusability. C1 UNIV MARYLAND,SCH MED,DEPT PHARMACOL & EXPTL THERAPEUT,BALTIMORE,MD 21201. USA,CTR RES DEV & ENGN,DIV BIOTECHNOL,EDGEWOOD,MD 21010. NR 24 TC 38 Z9 40 U1 2 U2 6 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0021-8561 J9 J AGR FOOD CHEM JI J. Agric. Food Chem. PD MAR PY 1993 VL 41 IS 3 BP 511 EP 516 DI 10.1021/jf00027a031 PG 6 WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science & Technology SC Agriculture; Chemistry; Food Science & Technology GA KT439 UT WOS:A1993KT43900031 ER PT J AU DYKSTRA, KD PAYNE, AM ABDELRAHIM, M FRANCIS, GL AF DYKSTRA, KD PAYNE, AM ABDELRAHIM, M FRANCIS, GL TI INSULIN-LIKE GROWTH FACTOR-I, BUT NOT GROWTH-HORMONE, HAS INVITRO PROLIFERATIVE EFFECTS ON NEONATAL FORESKIN FIBROBLASTS WITHOUT AFFECTING 5-ALPHA-REDUCTASE OR ANDROGEN RECEPTOR ACTIVITY SO JOURNAL OF ANDROLOGY LA English DT Article DE 5-ALPHA-REDUCTASE; ANDROGEN RECEPTOR; MICROPENIS ID MALE SEXUAL-DIFFERENTIATION; CULTURED HUMAN-FIBROBLASTS; INSENSITIVITY SYNDROME; SKIN FIBROBLASTS; MICROPENIS; DEFICIENCY; BINDING; HYPOGONADISM; SOMATOMEDINS; HYPOSPADIAS AB Clinical observation of patients with congenital growth hormone (GH) deficiency and Laron-type dwarfism suggests that factors such as GH or insulin-like growth factor 1 (IGF-1) might, in addition to androgens, be needed for normal phallic growth. We speculated GH or IGF-1 might have direct actions on genital tissues and performed the present study to evaluate the in vitro effects of GH and IGF-1 on cultured neonatal foreskin fibroblasts. Cells derived from foreskins of normal newborns were studied between cell passages 6 and 15. Serum-free media with and without 100 ng/ml GH, IGF-1, or both were added 24 hours prior to and at the time of study. To determine the activity of 5-alpha-reductase (5-alpha-R), H-3-testosterone (T; 2 nM) was added, and 5-alpha-R activity was calculated as femtomoles H-3-dihydrotestosterone and H-3-androstanediol produced/microgram DNA/hour. Androgen receptor (AR) binding was determined by the addition of H-3-dihydrotestosterone (dHT; 0.03125-0.5 nM) in the presence and absence of a 200-fold excess of unlabeled dHT. Specific binding was used in Scatchard analysis for determination of AR number (B(max)) and binding affinity (K(d)). The rate of DNA synthesis was determined by incorporation of H-3-thymidine (H-3-Thy) into trichloroacetic acid-insoluble material. DNA and protein content were determined on cell lysates. IGF-1, but not GH, had proliferative effects (significant increases in the rate of H-3-Thy incorporation, DNA, and protein content) but no effect on 5-alpha-R activity, B(max) or K(d). This suggests that IGF-1 has direct, in vitro, proliferative effects on genital tissue that are not mediated by changes in 5-alpha-R or AR. C1 WALTER REED ARMY MED CTR,DEPT PEDIAT,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,DEPT PEDIAT,BETHESDA,MD 20814. NR 44 TC 14 Z9 14 U1 2 U2 2 PU AMER SOC ANDROLOGY, INC PI LAWRENCE PA C/O ALLEN PRESS, INC PO BOX 368, LAWRENCE, KS 66044 SN 0196-3635 J9 J ANDROL JI J. Androl. PD MAR-APR PY 1993 VL 14 IS 2 BP 73 EP 78 PG 6 WC Andrology SC Endocrinology & Metabolism GA LB839 UT WOS:A1993LB83900001 PM 8514622 ER PT J AU BHATT, AR KIM, KW STROSCIO, MA LAFRATE, GJ DUTTA, M GRUBIN, HL HAQUE, R ZHU, XT AF BHATT, AR KIM, KW STROSCIO, MA LAFRATE, GJ DUTTA, M GRUBIN, HL HAQUE, R ZHU, XT TI REDUCTION OF INTERFACE PHONON MODES USING METAL-SEMICONDUCTOR HETEROSTRUCTURES SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID MOLECULAR-BEAM EPITAXY; OHMIC CONTACTS; QUANTUM WIRE; GROWTH; SUPERLATTICES; SCATTERING; TRANSISTOR; LAYERS; SYSTEM; HEIGHT AB Based on a simplified analysis of perfectly conducting metals, it has been suggested qualitatively that establishing metal-semiconductor interfaces at the heterojunctions of polar semiconductor quantum wells introduces a set of boundary conditions that dramatically reduces or eliminates unwanted carrier energy loss caused by interactions with interface longitudinal-optical (LO) phonon modes. In this article, it is theoretically demonstrated that comparable reductions in LO phonon scattering strengths may be achieved for metal-semiconductor structures with metal having realistic conductivities and Thomas-Fermi screening lengths. C1 USA,RES OFF,RES TRIANGLE PK,NC 27709. USA,RES LAB,ELECTR & POWER SOURCES DIRECTORATE,FT MONMOUTH,NJ 07703. SCI RES ASSOCIATES INC,GLASTONBURY,CT 06033. DUKE UNIV,DEPT PHYS,DURHAM,NC 27706. MOTOROLA INC,PHOENIX CORP RES LABS,TEMPE,AZ 85284. RP BHATT, AR (reprint author), N CAROLINA STATE UNIV,DEPT ELECT & COMP ENGN,RALEIGH,NC 27695, USA. NR 24 TC 22 Z9 22 U1 1 U2 5 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD MAR 1 PY 1993 VL 73 IS 5 BP 2338 EP 2342 DI 10.1063/1.353139 PG 5 WC Physics, Applied SC Physics GA KT868 UT WOS:A1993KT86800040 ER PT J AU HURLBERT, DF WHITE, LC POWELL, RD APT, C AF HURLBERT, DF WHITE, LC POWELL, RD APT, C TI ORGASM CONSISTENCY TRAINING IN THE TREATMENT OF WOMEN REPORTING HYPOACTIVE SEXUAL DESIRE - AN OUTCOME COMPARISON OF WOMEN-ONLY GROUPS AND COUPLES-ONLY GROUPS SO JOURNAL OF BEHAVIOR THERAPY AND EXPERIMENTAL PSYCHIATRY LA English DT Article ID GROUP-THERAPY; ASSERTIVENESS; PREOCCUPATION; PERSONALITY; ANORGASMIA; DEPRESSION; ESTEEM; SCALE AB To evaluate and compare the effectiveness and maintenance of two group interventions using orgasm consistency training in the treatment of female hypoactive sexual desire, 57 women were randomly assigned to a women-only group, a couples-only group, or a waiting list control group. Controlling for social desirability, subjects were assessed on six variables: sexual compatibility, sexual esteem, sexual desire, sexual fantasy, sexual assertiveness, and sexual satisfaction. Independent assessments were made on these variables before treatment, after treatment, and at 6 months follow-up. Although the treatment was found to be generally effective in women reporting hypoactive sexual desire, a consistent pattern of change favoring the couples-only group was evident on all measures. Possible explanations for the superiority of couples-only interventions are explored in the discussion. RP HURLBERT, DF (reprint author), USA,CTR ADULT & ADOLESCENT COUNSELING,324 N MAIN,BELTON,TX 76513, USA. NR 53 TC 40 Z9 40 U1 3 U2 5 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0005-7916 J9 J BEHAV THER EXP PSY JI J. Behav. Ther. Exp. Psychiatry PD MAR PY 1993 VL 24 IS 1 BP 3 EP 13 DI 10.1016/0005-7916(93)90003-F PG 11 WC Psychology, Clinical; Psychiatry SC Psychology; Psychiatry GA LN294 UT WOS:A1993LN29400001 PM 8370794 ER PT J AU ROTHWELL, SW NATH, J WRIGHT, DG AF ROTHWELL, SW NATH, J WRIGHT, DG TI RAPID AND REVERSIBLE TUBULIN TYROSINATION IN HUMAN NEUTROPHILS STIMULATED BY THE CHEMOTACTIC PEPTIDE, FMET-LEU-PHE SO JOURNAL OF CELLULAR PHYSIOLOGY LA English DT Article ID HUMAN POLYMORPHONUCLEAR LEUKOCYTES; MICROTUBULE-ASSOCIATED PROTEINS; ALPHA-TUBULIN; CYTOPLASMIC MICROTUBULES; DETYROSINATED TUBULIN; TERMINAL TYROSINE; SQUID AXOPLASM; BINDING-SITES; CELL-LINE; INVIVO AB Neutrophil activation by specific stimuli, such as the oligopeptide chemotactic factor fMet-Leu-Phe (fMLF), is associated with an increased enzymatic addition of tyrosine to tubulin alpha-subunits, as measured by C-14 tyrosine uptake. In studies using immunoblots we have found that this increased tyrosine uptake into tubulin in activated neutrophils reflects an increase in the proportion of cellular tubulin that is tyrosinated rather than simply an increase in the turnover of tyrosinated subunits. However, the increased accumulation of tyrosinated tubulin was also found to follow an initial depletion of tyrosinated tubulin and concomitant increase in detyrosinated tubulin between 0 and 60 sec following stimulation of neutrophils with fMLF. Immunogold electron microscopy studies of intact microtubules recovered from activated neutrophils demonstrated that these rapid changes in the relative content of tubulin isoforms in the cells were not associated with the formation or disappearance of microtubule microdomains composed of only one form of tubulin. Previously, we have shown that under conditions of fMLF-stimulated exocytosis there is an increased binding of neutrophil granules to endogenous microtubules. Since neutrophil activation by fMLF is associated with increased tyrosination of alpha-tubulin subunits, we speculated that rapid changes in the levels of tyrosinated tubulin in the microtubules of activated neutrophils might have a role in the regulation of granule-microtubule interactions. When the binding of purified neutrophil granules to reconstituted rat brain microtubules containing approximately 50% tyrosinated tubulin was measured by electron microscopy and compared with granule binding to microtubules that contained no detectable tyrosinated tubulin, granule-microtubule associations were found to be significantly favored by detyrosinated vs. tyrosinated tubulin. These findings indicate that interactions between cytoplasmic granules and microtubules in activated neutrophils may be modulated by rapid changes in the relative content of detyrosinated and tyrosinated tubulin in the microtubule network of the cells. RP WALTER REED ARMY INST RES, DEPT HEMATOL, WASHINGTON, DC 20307 USA. NR 62 TC 10 Z9 10 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0021-9541 EI 1097-4652 J9 J CELL PHYSIOL JI J. Cell. Physiol. PD MAR PY 1993 VL 154 IS 3 BP 582 EP 592 DI 10.1002/jcp.1041540317 PG 11 WC Cell Biology; Physiology SC Cell Biology; Physiology GA KP604 UT WOS:A1993KP60400016 PM 8436605 ER PT J AU CAMPBELL, J LOWE, J WALZ, S EZZELL, J AF CAMPBELL, J LOWE, J WALZ, S EZZELL, J TI RAPID AND SPECIFIC IDENTIFICATION OF YERSINIA-PESTIS BY USING A NESTED POLYMERASE CHAIN-REACTION PROCEDURE SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article AB We developed a 4-h nested polymerase chain reaction assay that detected a region of the plasminogen activator gene of Yersinia pestis in 100% of 43 Y. pestis strains isolated from humans, rats, and fleas yet was unreactive with the closely related species Yersinia enterocolitica and Yersinia pseudotuberculosis. C1 USA,MED RES INST INFECT DIS,FT DETRICK,MD 21702. RP CAMPBELL, J (reprint author), USN,RES LAB,CODE 6900,WASHINGTON,DC 20375, USA. NR 6 TC 28 Z9 36 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD MAR PY 1993 VL 31 IS 3 BP 758 EP 759 PG 2 WC Microbiology SC Microbiology GA KM810 UT WOS:A1993KM81000063 PM 8458980 ER PT J AU BRITSCH, LD DUNBAR, JB AF BRITSCH, LD DUNBAR, JB TI LAND LOSS RATES - LOUISIANA COASTAL-PLAIN SO JOURNAL OF COASTAL RESEARCH LA English DT Article DE LOUISIANA COASTAL PLAIN; MISSISSIPPI RIVER DELTAIC PLAIN; MISSISSIPPI RIVER CHENIER PLAIN; LAND LOSS; LAND LOSS RATES; COASTAL EROSION ID WETLAND AB Land loss mapping and rate curve development for 62 quadrangles in the Mississippi River deltaic and chenier plains shows that land loss rates and trends vary significantly throughout coastal Louisiana. Land loss rates were defined for each quadrangle for 4 time periods (1930's to 1956-1958, 1956-1958 to 1974, 1974 to 1983, and 1983 to 1990). Differences in land loss rates among the individual quadrangles are a function of the geologic and hydrologic setting and the factors which contribute to land loss such as subsidence, storm induced erosion, channelization of streams and rivers, and canal dredging. Of the 62 quadrangles mapped, 8 quadrangles are losing more than 1 percent of their land area each year, while 21 quadrangles are losing more than 0.5 percent per year during the 1983 to 1990 period. On a regional scale, the land loss rate for the entire Louisiana Coastal Plain has decreased from an average yearly rate of 41.83 square miles in the 1956-1958 to 1974 period to 25.34 square miles during the 1983 to 1990 period. The percentage of land being lost is also decreasing from 0.51 percent per year in the 1956-1958 to 1974 period to 0.35 percent per year during the 1983 to 1990 period. The regional land loss rate will probably continue to decrease slowly until a background rate is reached. C1 USAE,WATERWAYS EXPT STN,GEOTECH LAB GGYG,VICKSBURG,MS 39180. RP BRITSCH, LD (reprint author), USA,ENGINEER DIST,NEW ORLEANS FDN & MAT BRANCH ED FG,NEW ORLEANS,LA 70160, USA. NR 21 TC 123 Z9 123 U1 5 U2 37 PU COASTAL EDUCATION & RESEARCH FOUNDATION PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 SN 0749-0208 J9 J COASTAL RES JI J. Coast. Res. PD SPR PY 1993 VL 9 IS 2 BP 324 EP 338 PG 15 WC Environmental Sciences; Geography, Physical; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Physical Geography; Geology GA KW243 UT WOS:A1993KW24300002 ER PT J AU BRIGGS, MJ AF BRIGGS, MJ TI MAKING WAVES AT CERC SO JOURNAL OF COASTAL RESEARCH LA English DT Article DE COASTAL ENGINEERING; PHYSICAL MODEL TESTING; WAVE-MAKERS; DIRECTIONAL WAVE SPECTRA; WAVE TRANSFORMATION PROPAGATION; WAVE SHOALING AND REFRACTION; JETTY STABILITY; HARBOR RESONANCE ID WATER AB This paper describes a unique wavemaker for the generation of naturally occurring shallow water waves in laboratory experiments. The main feature of this wavemaker is its ability to simulate waves of many different periods and directions at one time. This combination of multiple waves is more representative of the sea and swell waves that occur naturally in lakes and oceans. Recent research involving wave shoaling over a submerged mound, stability of a harbor entrance jetty, and wave transformation in a harbor is presented to illustrate the versatility of this wavemaker. RP BRIGGS, MJ (reprint author), USA,ENGINEER WATERWAYS EXPT STN,COASTAL ENGN RES CTR,VICKSBURG,MS 39180, USA. NR 18 TC 2 Z9 2 U1 0 U2 0 PU COASTAL EDUCATION & RESEARCH FOUNDATION PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 SN 0749-0208 J9 J COASTAL RES JI J. Coast. Res. PD SPR PY 1993 VL 9 IS 2 BP 448 EP 461 PG 14 WC Environmental Sciences; Geography, Physical; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Physical Geography; Geology GA KW243 UT WOS:A1993KW24300012 ER PT J AU URBAN, JJ FAMINI, GR AF URBAN, JJ FAMINI, GR TI CONFORMATIONAL DEPENDENCE OF THE ELECTROSTATIC POTENTIAL-DERIVED CHARGES OF DOPAMINE - RAMIFICATIONS IN MOLECULAR MECHANICS FORCE-FIELD CALCULATIONS IN THE GAS-PHASE AND IN AQUEOUS-SOLUTION SO JOURNAL OF COMPUTATIONAL CHEMISTRY LA English DT Article ID ATOMIC CHARGES; DISTRIBUTED MULTIPOLE; DYNAMICS SIMULATIONS; NUCLEIC-ACIDS; HYDROGEN-BOND; FREE-ENERGIES; SOLVATION; WATER; PROTEINS; PEPTIDES AB The electrostatic potential-derived charges for the catecholamine neurotransmitter dopamine were calculated at the STO-3G and 6-31G* basis sets for six different molecular conformations. The degree of variance of the charges with changing conformations was examined. The 6-31G* basis set produced charges that were more sensitive to changes in conformation than those derived from the STO-3G electrostatic potentials. The implication of the charge variations in molecular mechanics calculations was also investigated. The molecular mechanics results in the gas phase exhibited a variance depending upon the charge set used. The force field calculations varied much less when aqueous solvation was included in the calculations through a continuum model. RP URBAN, JJ (reprint author), USA,EDGEWOOD RES DEV & ENGN CTR,SCBRD RT,BLDG E3160,ABERDEEN PROVING GROUND,MD 21010, USA. NR 49 TC 29 Z9 29 U1 0 U2 4 PU JOHN WILEY & SONS INC PI NEW YORK PA 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0192-8651 J9 J COMPUT CHEM JI J. Comput. Chem. PD MAR PY 1993 VL 14 IS 3 BP 353 EP 362 DI 10.1002/jcc.540140310 PG 10 WC Chemistry, Multidisciplinary SC Chemistry GA KL482 UT WOS:A1993KL48200009 ER PT J AU SENGUPTA, LC SENGUPTA, S KOSIK, WE DEMAREE, JD AF SENGUPTA, LC SENGUPTA, S KOSIK, WE DEMAREE, JD TI SURFACE-ANALYSIS OF LN2-XCEXCUO4 (LN = PR AND ND) SINGLE-CRYSTALS GROWN BY THE TOP SEEDED SOLUTION METHOD SO JOURNAL OF CRYSTAL GROWTH LA English DT Article; Proceedings Paper CT 10TH INTERNATIONAL CONF ON CRYSTAL GROWTH ( ICGG-10 ) CY AUG 16-21, 1992 CL SAN DIEGO, CA ID SUPERCONDUCTING OXIDES AB Large single crystals of Ln2-xCexCuO4 (Ln = Pr and Nd), of the average size of approximately 5 mm X 5 mm X 1 mm, were grown by the top seeded solution growth (TSSG) technique. The optical constants of the crystals were determined by variable angle spectroscopic ellipsometry (VASE) and the results seem to indicate that a 1.5 eV absorption peak appears in the undoped material and is weakened and shifted downward in energy upon annealing. The compositions and crystal structure were examined using rutherford backscattering spectroscopy (RBS) with ion beam channeling. Also, the effect of annealing on the crystalline structure was probed by ion beam channeling. The orientation and lattice parameters of the crystals were determined by X-ray diffraction and the superconductivity of the specimens was monitored using a SQUID magnetometer. The results indicate that the crystals grown by the TSSG method are very uniform in composition and well-oriented. However, analysis of the RBS data indicated up to 1% Pt inclusion in the crystals from contact with the Pt crucibles. The inclusion of Pt acted to quench the superconducting transition temperatures and Pt was found to substitute for Cu. C1 MIT,CTR MAT SCI & ENGN,ADV SOLID STATE LASER MAT LAB,CAMBRIDGE,MA 02139. USA,MAT TECHNOL LAB,MAT RES BRANCH,WATERTOWN,MA 02172. RP SENGUPTA, LC (reprint author), USA,MAT TECHNOL LAB,CERAM RES BRANCH,WATERTOWN,MA 02172, USA. NR 14 TC 0 Z9 0 U1 0 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-0248 J9 J CRYST GROWTH JI J. Cryst. Growth PD MAR PY 1993 VL 128 IS 1-4 BP 817 EP 823 DI 10.1016/S0022-0248(07)80051-0 PN 2 PG 7 WC Crystallography; Materials Science, Multidisciplinary; Physics, Applied SC Crystallography; Materials Science; Physics GA KV697 UT WOS:A1993KV69700050 ER PT J AU FOSTER, KH KULILD, JC WELLER, RN AF FOSTER, KH KULILD, JC WELLER, RN TI EFFECT OF SMEAR LAYER REMOVAL ON THE DIFFUSION OF CALCIUM HYDROXIDE THROUGH RADICULAR DENTIN SO JOURNAL OF ENDODONTICS LA English DT Article ID TEETH; ROOT; BARRIERS AB Forty single-rooted teeth were sectioned transversely through the cementoenamel junction and instrumented to a size #50 K-Flex file at the working length by saline irrigation. Each root was placed in a dilution vial containing 10 ml of normal saline, and the pH and Ca2+ levels were recorded after 24 h. The roots in group 1 then received a final irrigation with 20 ml of normal saline. Group 2 received a final irrigation with 10 ml of 17% ethylenediaminetetraacetic acid followed by 10 ml of 5.25% NaOCl to remove the smear layer. Group 3 was irrigated in the same manner as group 2, but calcium hydroxide (CH) was placed into the root canal. Group 4 was irrigated with 20 ml of NaOCl, and CH was placed into the root canal. The pH and Ca2+ levels were recorded at 1, 3, 5, and 7 days. After 7 days a 3- x 3- x 1 -mm external defect was created in the coronal one third of the root surface. The pH and Ca2+ levels were subsequently recorded at 1, 3, and 7 days. Groups 3 and 4 demonstrated significantly higher H+ and Ca2+ levels than did groups 1 and 2 three days after CH placement and at all subsequent intervals. Group 3 demonstrated significantly higher H+ and Ca2+ readings at some but not all intervals. The results demonstrated that CH diffuses from the root canal to the exterior surface of the root and that the removal of the smear layer may facilitate this diffusion. C1 USA DENT ACT,US ARMY POSTGRAD DENT SCH,ENDODONT RESIDENCY PROGRAM,FT GORDON,GA. RP FOSTER, KH (reprint author), USA DENT ACT,FT CLAYTON,PANAMA. NR 17 TC 44 Z9 50 U1 0 U2 1 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0099-2399 J9 J ENDODONT JI J. Endod. PD MAR PY 1993 VL 19 IS 3 BP 136 EP 140 DI 10.1016/S0099-2399(06)80508-X PG 5 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA KP607 UT WOS:A1993KP60700006 PM 8509752 ER PT J AU JONES, KF AF JONES, KF TI COUPLED VERTICAL AND HORIZONTAL GALLOPING - CLOSURE SO JOURNAL OF ENGINEERING MECHANICS-ASCE LA English DT Discussion RP JONES, KF (reprint author), USA,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU ASCE-AMER SOC CIVIL ENGINEERS PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-9399 J9 J ENG MECH-ASCE JI J. Eng. Mech.-ASCE PD MAR PY 1993 VL 119 IS 3 BP 641 EP 641 DI 10.1061/(ASCE)0733-9399(1993)119:3(641) PG 1 WC Engineering, Mechanical SC Engineering GA LQ776 UT WOS:A1993LQ77600015 ER PT J AU APT, C HURLBERT, DF AF APT, C HURLBERT, DF TI THE SEXUALITY OF WOMEN IN PHYSICALLY ABUSIVE MARRIAGES - A COMPARATIVE-STUDY SO JOURNAL OF FAMILY VIOLENCE LA English DT Article DE ABUSED WOMEN; DOMESTIC VIOLENCE; FEMALE SEXUALITY; INTIMACY; SEXUAL BEHAVIOR; MARITAL SEXUALITY ID AROUSABILITY; INVENTORY; SCALE AB To examine female sexuality in physically abusive marriages, this study compared 60 abused women with a demographically matched sample of nonabused women in distressed marriages (aged 19-29). The physically abused women reported significantly lower levels of intimacy and compatibility in their marriages. In addition, abused women were found to evince a more traditional sex-role ideology, a greater negative or erotophobic disposition toward sex, and a stronger avoidance of sex than did nonabused women. Also, as compared to nonabused women in distressed marriages, the abused women rated themselves as having a lower degree of sexual assertiveness, arousability, and satisfaction. Despite these findings, the abused women reported a significantly greater frequency of sexual intercourse in their marriages than did the nonabused women. C1 USA,BELTON,TX 76513. NR 31 TC 23 Z9 24 U1 1 U2 5 PU PLENUM PUBL CORP PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 SN 0885-7482 J9 J FAM VIOLENCE JI J. Fam. Violence PD MAR PY 1993 VL 8 IS 1 BP 57 EP 69 DI 10.1007/BF00986993 PG 13 WC Psychology, Clinical; Family Studies SC Psychology; Family Studies GA KM602 UT WOS:A1993KM60200004 PM 12295448 ER PT J AU MUNAVALLI, S ROSSMAN, DI ROHRBAUGH, DK FERGUSON, CP AF MUNAVALLI, S ROSSMAN, DI ROHRBAUGH, DK FERGUSON, CP TI UNUSUAL REACTION OF GRIGNARD-REAGENTS WITH BIS(TRIFLUOROMETHYL)DISULFIDE SO JOURNAL OF FLUORINE CHEMISTRY LA English DT Article ID UNSYMMETRICAL DIALKYL DISULFIDES; MECHANISM; MAGNESIUM; SURFACE; ALKYL AB Simultaneous scission of the C-S and S-S bonds of bis(trifluoromethyl)disulfide occurs on treatment with Grignard reagents at -78-degrees-C and gives rise to unsymmetrical disulfides and sulfides as well as alkyl sulfides. Under similar experimental conditions, alkyl disulfides are recovered unreacted. Probable mechanisms of the cleavage reactions are presented. C1 USA,EDGEWOOD RES DEV & ENGN CTR,ABERDEEN PROVING GROUND,MD 21010. RP MUNAVALLI, S (reprint author), GEOCENTERS INC,FT WASHINGTON,MD 20744, USA. NR 33 TC 14 Z9 14 U1 0 U2 1 PU ELSEVIER SCIENCE SA LAUSANNE PI LAUSANNE 1 PA PO BOX 564, 1001 LAUSANNE 1, SWITZERLAND SN 0022-1139 J9 J FLUORINE CHEM JI J. Fluor. Chem. PD MAR PY 1993 VL 61 IS 1-2 BP 147 EP 153 DI 10.1016/S0022-1139(00)80425-X PG 7 WC Chemistry, Inorganic & Nuclear; Chemistry, Organic SC Chemistry GA KR408 UT WOS:A1993KR40800016 ER PT J AU MUNAVALLI, S ROSSMAN, DI ROHRBAUGH, DK FERGUSON, CP AF MUNAVALLI, S ROSSMAN, DI ROHRBAUGH, DK FERGUSON, CP TI NOVEL REACTION OF BIS(TRIFLUOROMETHYL)DISULFIDE WITH ORGANOLITHIUM REAGENTS SO JOURNAL OF FLUORINE CHEMISTRY LA English DT Article ID UNSYMMETRICAL DIALKYL DISULFIDES; VOLATILE FLAVOR COMPONENTS; SINGLE-ELECTRON-TRANSFER; ALKYL RADICALS; HALIDES AB The reaction of bis(trifluoromethyl) disulfide with organolithium reagents at -78-degrees-C results in simultaneous scission of both the C-S and S-S bonds. Under similar conditions, the alkyl and aryl disulfides undergo only S-S bond cleavage. This unusual behavior of bis(trifluoromethyl) disulfide is due to the presence of the trifluoromethyl function. The product distribution, the mechanism of bond fission and the mass spectral data of compounds thus formed are presented in this paper. C1 GEOCENTERS INC,FT WASHINGTON,MD 20744. RP MUNAVALLI, S (reprint author), USA,EDGEWOOD RES DEV & ENGN CTR,ABERDEEN PROVING GROUND,MD 21010, USA. NR 47 TC 4 Z9 4 U1 0 U2 1 PU ELSEVIER SCIENCE SA LAUSANNE PI LAUSANNE 1 PA PO BOX 564, 1001 LAUSANNE 1, SWITZERLAND SN 0022-1139 J9 J FLUORINE CHEM JI J. Fluor. Chem. PD MAR PY 1993 VL 61 IS 1-2 BP 155 EP 161 DI 10.1016/S0022-1139(00)80426-1 PG 7 WC Chemistry, Inorganic & Nuclear; Chemistry, Organic SC Chemistry GA KR408 UT WOS:A1993KR40800017 ER PT J AU JOHNSON, ED KOTOWSKI, TM AF JOHNSON, ED KOTOWSKI, TM TI DETECTION OF PROSTATE SPECIFIC ANTIGEN BY ELISA SO JOURNAL OF FORENSIC SCIENCES LA English DT Article DE PATHOLOGY AND BIOLOGY; PROSTATE SPECIFIC ANTIGEN; P-30; ELISA ID P-30 ANTIGEN; PROTEIN AB A method for the detection of prostate specific antigen (PSA or P30) by enzyme linked immunosorbent assay (ELISA) has been developed. The method was evaluated for sensitivity and specificity and compared to other methods of semen identification on numerous casework samples. A sensitivity of less than 1 ng/mL PSA is routinely achieved. Numerous domestic contaminants and body fluids were tested and none were found to give a false-positive result. However, false-negative results did occur in samples contaminated with detergents. Additionally, some poorly preserved items of evidence did not give positive results where expected. In spite of these minor limitations, this method was found to be highly sensitive and specific and an efficient method for identifying semen in forensic casework. RP JOHNSON, ED (reprint author), USA,CRIME LAB,CONUS,BLDG 213-B,FT GILLEM,GA 30050, USA. NR 16 TC 32 Z9 33 U1 0 U2 7 PU AMER SOC TESTING MATERIALS PI W CONSHOHOCKEN PA 100 BARR HARBOR DR, W CONSHOHOCKEN, PA 19428-2959 SN 0022-1198 J9 J FORENSIC SCI JI J. Forensic Sci. PD MAR PY 1993 VL 38 IS 2 BP 250 EP 258 PG 9 WC Medicine, Legal SC Legal Medicine GA KR555 UT WOS:A1993KR55500006 PM 7681096 ER PT J AU LITTLE, JS LUKEY, BJ SHIMOMURA, ET FUHRMANN, LS AF LITTLE, JS LUKEY, BJ SHIMOMURA, ET FUHRMANN, LS TI MILITARY DRUG POSITIVE RATES IN THE EUROPEAN THEATER DRUG RATES IN EUROPE SO JOURNAL OF FORENSIC SCIENCES LA English DT Article DE TOXICOLOGY; DRUG ABUSE; MILITARY; GAS CHROMATOGRAPHY MASS SPECTROMETRY; GAS ANALYSIS; URINALYSIS; RADIOIMMUNOASSAY; MARIJUANA; COCAINE; THC ID ABUSE; PREVALENCE; PERSONNEL AB Urine samples were collected from Air Force and Army service members within the European Theater and analyzed for drugs of abuse employing radioimmunoassay and gas chromatography/mass spectroscopy (GC/MS). Data collected from January 1985 through December 1991 indicate that the total positive rate decreased from 4.67%, to 0.69%. Of the drugs tested, tetrahydrocannabinol (THC) was the drug abused most in the European Theater during this time period. C1 USA,ENVIRONM HYG AGCY,DIV QUAL ASSURANCE,ABERDEEN PROVING GROUND,MD 21010. USA,MED RES & DEV COMMAND,FREDERICK,MD 21701. MED LAB 10,LANDSTUHL,GERMANY. RP LITTLE, JS (reprint author), USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010, USA. NR 17 TC 4 Z9 4 U1 0 U2 0 PU AMER SOC TESTING MATERIALS PI W CONSHOHOCKEN PA 100 BARR HARBOR DR, W CONSHOHOCKEN, PA 19428-2959 SN 0022-1198 J9 J FORENSIC SCI JI J. Forensic Sci. PD MAR PY 1993 VL 38 IS 2 BP 259 EP 265 PG 7 WC Medicine, Legal SC Legal Medicine GA KR555 UT WOS:A1993KR55500007 PM 8454986 ER PT J AU NORWOOD, VM CRAFT, DJ KEEHAN, KR AF NORWOOD, VM CRAFT, DJ KEEHAN, KR TI FEASIBILITY OF USING NITROCELLULOSE SOLVENT NO 2 FUEL-OIL SOLUTIONS AS FUEL SUPPLEMENTS FOR INDUSTRIAL COMBUSTORS SO JOURNAL OF HAZARDOUS MATERIALS LA English DT Article AB The U.S. Army Toxic and Hazardous Materials Agency (USATHAMA) is currently conducting a program with the Tennessee Valley Authority (TVA) to determine the feasibility of utilizing propellants as supplemental fuels for the U.S. Army's industrial combustors. Disposing of obsolete and waste propellants in this manner could be both cost-effective and environmentally sound, and as an added benefit would utilize the energy value of these materials. Tests were conducted to evaluate the physical and chemical characteristics, as well as the chemical compatability, of nitrocellulose (NC) solvent No. 2 fuel oil solutions. Acetone, ethyl acetate, and butyl acetate were tested as solvents for NC. The results from these tests, coupled with an economic analysis, indicated that solvation of NC with the best solvent tested, acetone, and mixing with No. 2 fuel oil was not technically feasible or cost effective due to the low solubility of the NC. However, the economic analysis did indicate potential cost effectiveness using propellant No. 2 fuel oil slurries as supplemental fuels. C1 USA,TOXIC & HAZARDOUS MAT AGCY,ABERDEEN PROVING GROUND,MD 21010. RP NORWOOD, VM (reprint author), TENNESSEE VALLEY AUTHOR,1101 MARKET ST,CHATTANOOGA,TN 37402, USA. NR 19 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3894 J9 J HAZARD MATER JI J. Hazard. Mater. PD MAR PY 1993 VL 33 IS 3 BP 319 EP 327 DI 10.1016/0304-3894(93)85082-P PG 9 WC Engineering, Environmental; Engineering, Civil; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA KR242 UT WOS:A1993KR24200001 ER PT J AU GLASS, GE WATSON, AJ LEDUC, JW KELEN, GD QUINN, TC CHILDS, JE AF GLASS, GE WATSON, AJ LEDUC, JW KELEN, GD QUINN, TC CHILDS, JE TI INFECTION WITH A RATBORNE HANTAVIRUS IN UNITED-STATES RESIDENTS IS CONSISTENTLY ASSOCIATED WITH HYPERTENSIVE RENAL-DISEASE SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID HEMORRHAGIC-FEVER; NEPHROPATHIA-EPIDEMICA; SYNDROME VIRUSES; RAT-POPULATIONS; BALTIMORE; ANTIBODY; MARYLAND AB A survey of 8080 subjects was conducted in Baltimore, examining the association between infection with hantaviruses and renal disease. Two groups (N = 6060) with no known risk factors were selected to establish a baseline antibody prevalence. Overall, antibody prevalence was 0.25%. Seroprevalence increased with age, without sex- or race-related differences. Patients with proteinuria showed the same patterns of infection but were more commonly seropositive (1.46%) than the reference group (OR, 3.23; P < .05). Infection among dialysis patients with end-stage renal disease was 2.76%, significantly higher than in the reference group (OR, 5.03; P < .05). In the proteinuria and the dialysis groups, hantavirus infection was consistently associated with a diagnosis of hypertensive renal disease. The association was unrelated to other chronic renal disease diagnoses. Overall, 6.5% of patients with end-stage renal disease due to hypertension were seropositive for a hantavirus. These data suggest that hantavirus infection is associated with hypertensive renal disease. C1 JOHNS HOPKINS UNIV, SCH MED, DEPT NEPHROL, BALTIMORE, MD 21205 USA. JOHNS HOPKINS UNIV, SCH MED, DIV EMERGENCY MED, BALTIMORE, MD 21205 USA. JOHNS HOPKINS UNIV, SCH MED, DIV INFECT DIS, BALTIMORE, MD 21205 USA. USA, MED RES INST INFECT DIS, DEPT EPIDEMIOL, DIV DIS ASSESSMENT, FT DETRICK, MD USA. NIAID, IMMUNOREGULAT LAB, BETHESDA, MD 20892 USA. RP GLASS, GE (reprint author), JOHNS HOPKINS UNIV, SCH HYG & PUBL HLTH, DEPT IMMUNOL & INFECT DIS, 615 N WOLFE ST, BALTIMORE, MD 21205 USA. RI Quinn, Thomas/A-2494-2010; Childs, James/B-4002-2012; OI Kelen, Gabor/0000-0002-3236-8286 NR 47 TC 104 Z9 105 U1 0 U2 0 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 1537-6613 J9 J INFECT DIS JI J. Infect. Dis. PD MAR PY 1993 VL 167 IS 3 BP 614 EP 620 PG 7 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA KN152 UT WOS:A1993KN15200014 PM 8095060 ER PT J AU BRYAN, JP SJOGREN, MH MALONE, JL MACARTHY, P KAO, TC WAGNER, K SHEFFIELD, J SMITH, E PERINE, PL AF BRYAN, JP SJOGREN, MH MALONE, JL MACARTHY, P KAO, TC WAGNER, K SHEFFIELD, J SMITH, E PERINE, PL TI RECOMBINANT IMMUNOBLOT ASSAYS FOR HEPATITIS-C IN HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 - INFECTED UNITED-STATES NAVY PERSONNEL SO JOURNAL OF INFECTIOUS DISEASES LA English DT Note ID UNITED-STATES; RISK-FACTORS; ANTIBODY; HIV; MEN AB The prevalence of hepatitis A, B, C, and D viruses was studied in 467 military personnel with human immunodeficiency virus type 1 (HIV-1) infection. Antibody to hepatitis C virus (anti-HCV) by first-generation ELISA was found in 136 (29%). Of sera repeatedly reactive for anti-HCV by first-generation ELISA, two-antigen recombinant immunoblot assay (RIBA) was positive in 41 (32%) and four-antigen RIBA was positive in 55 (41%). Four-antigen RIBA was positive in 33 (30%) of the 109 with an OD on ELISA of less-than-or-equal-to 2.0 compared with 22 (81%) of the 27 with an OD >2.0 (P < .001). Anti-HCV detected by four-antigen RIBA was associated with increasing age, black or Hispanic race, and antibody to hepatitis B core antigen. When patients with hepatitis B surface antigen were excluded, elevated alanine aminotransferase was found in 5 (8%) of 63 with a negative RIBA and 13 (28%) of 47 with a positive RIBA (P = .006). While RIBA was negative in more than half of those with anti-HCV by ELISA, 55 (12%) of these HIV-1 infected personnel had anti-HCV detected by RIBA, which was associated with a strong reaction by ELISA, elevated liver enzymes, coinfection with hepatitis B, minority race, and older age. C1 NATL NAVAL MED CTR, BETHESDA, MD 20814 USA. WALTER REED ARMY INST RES, WASHINGTON, DC 20307 USA. RP BRYAN, JP (reprint author), UNIFORMED SERV UNIV HLTH SCI, DEPT PREVENT MED & BIOMETR, 4301 JONES BRIDGE RD, BETHESDA, MD 20814 USA. NR 15 TC 7 Z9 7 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD MAR PY 1993 VL 167 IS 3 BP 715 EP 719 PG 5 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA KN152 UT WOS:A1993KN15200027 PM 8382719 ER PT J AU DURDEN, LA LOGAN, TM WILSON, ML LINTHICUM, KJ AF DURDEN, LA LOGAN, TM WILSON, ML LINTHICUM, KJ TI EXPERIMENTAL VECTOR INCOMPETENCE OF A SOFT TICK, ORNITHODOROS-SONRAI (ACARI, ARGASIDAE), FOR CRIMEAN-CONGO HEMORRHAGIC-FEVER VIRUS SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Note DE ORNITHODOROS-SONRAI; CRIMEAN-CONGO HEMORRHAGIC FEVER VIRUS; VECTOR COMPETENCE ID TRANSMISSION AB Adults and nymphs of a soft tick, Ornithodoros sonrai Sautet & Witkowski, were allowed to feed on suckling mice that had been experimentally infected with Crimean-Congo hemorrhagic fever (CCHF) virus (IbAr 10200 strain). The mean viral titer of mouse blood at the time of tick feeding was 10(3.2) plaque-forming units (PFU) per ml. Samples of ticks were assayed on 12 occasions between days 0 and 31 after the viremic blood meal. Mean CCHF viral titers were 10(2.1) PFU per tick immediately after the viremic meal but declined to 10(1.2) PFU per tick after 2 d, and no virus was detected beyond 8 d. The percentage of ticks with detectable virus was 92% (22/24) immediately after the viremic meal, but then declined to 20% (2/10) after 4 d and to 0% (0/44) after 11 or more days. Ticks were allowed to feed on sets of three naive suckling mice on days 0, 2, 5, 8, 11, 14, 21, and 28 after the viremic blood meal, but CCHF viral transmission did not occur. Similarly, no transovarial transmission of virus from CCHF virus-exposed O. sonrai to their progeny was observed. These results strongly indicate that O. sonrai is not a vector of CCHF virus. C1 USA,MED RES INST INFECT DIS,DIV DIS ASSESSMENT,FREDERICK,MD 21702. NR 15 TC 13 Z9 15 U1 0 U2 0 PU ENTOMOL SOC AMER PI LANHAM PA 9301 ANNAPOLIS RD, LANHAM, MD 20706 SN 0022-2585 J9 J MED ENTOMOL JI J. Med. Entomol. PD MAR PY 1993 VL 30 IS 2 BP 493 EP 496 PG 4 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA KP402 UT WOS:A1993KP40200031 PM 8459431 ER PT J AU MAXWELL, DM BRECHT, KM DOCTOR, BP WOLFE, AD AF MAXWELL, DM BRECHT, KM DOCTOR, BP WOLFE, AD TI COMPARISON OF ANTIDOTE PROTECTION AGAINST SOMAN BY PYRIDOSTIGMINE, HI-6 AND ACETYLCHOLINESTERASE SO JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS LA English DT Article ID CARBOXYLESTERASE INHIBITION; TOXICITY; PRETREATMENT; PROPHYLAXIS; PRIMATES; THERAPY; OXIMES; MICE; BUTYRYLCHOLINESTERASE; INTOXICATION AB Carbamate, oxime and enzyme scavenger approaches to protection against the highly toxic organophosphorus compound, soman, were compared by using the most prominent example of each type of antidote. Pyridostigmine in combination with atropine, Hl-6 [1-(2-(hydroxyimino)methyl))pyridinium-2-(4-(aminocarbonyl)pyridinium)dimethylether] in combination with atropine and fetal bovine serum acetylcholinesterase (FBS-AChE) without atropine were used as examples of oxime, carbamate and enzyme scavenger antidotes, respectively. Each antidotal regimen produced approximately equal maximal protection against the lethal effects of 952 to 11 69 nmol/kg (LD50, 8-1 0) of soman in mice whose carboxylesterase had been inhibited with 2-(o-cresyl)-4H-1:3:2-benzodioxaphosphorin-2-oxide. FBS-AChE was much better than either pyridostigmine-atropine or Hl-6-atropine in reducing postexposure incapacitation from soman as measured by lacrimation, motor dysfunction, activity level and the inverted screen test. A lower dose of pyridostigmine (566 nmol/kg) or FBS-AChE (11 50 nmol/kg) was required to protect against 968 nmol/kg (LD50, 8) of soman than was required for Hl-6 (200,000 nmol/kg). In as much as the in vivo biological half-life of FBS-AChE (1550 min) was much greater than the biological half-lives of pyridostigmine (48 min) or Hl-6 (11 min), the ability of FBS-AChE to produce better protection against the postexposure incapacitation from soman suggests that it should be considered as an alternative to either pyridostigmine-atropine or Hl-6-atropine antidotal regimens. C1 WALTER REED ARMY INST RES,WASHINGTON,DC 20307. RP MAXWELL, DM (reprint author), USA,MED RES INST CHEM DEFENSE,BIOCHEM PHARMACOL BRANCH,ABERDEEN PROVING GROUND,MD 21010, USA. NR 33 TC 35 Z9 35 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-3565 J9 J PHARMACOL EXP THER JI J. Pharmacol. Exp. Ther. PD MAR PY 1993 VL 264 IS 3 BP 1085 EP 1089 PG 5 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA KT846 UT WOS:A1993KT84600010 PM 8450452 ER PT J AU CROSLAND, RD AF CROSLAND, RD TI EFFECT OF ARACHIDONIC-ACID ON TWITCH TENSION OF THE RAT PHRENIC NERVE-DIAPHRAGM SO JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS LA English DT Article ID FATTY-ACIDS; GLUTAMATE RELEASE; CHOLINE UPTAKE; SYNAPTOSOMES; BRAIN; PROSTAGLANDINS; ENHANCEMENT AB Recent studies have demonstrated that unsaturated fatty acids are involved in the regulation of neuroeffector function. I have extended these studies by examining the effect of arachidonic acid on neuromuscular function in vitro using the rat phrenic nerve-diaphragm preparation. Arachidonic acid caused a time-and dose-dependent reduction in indirectly stimulated twitch tension, but had no effect on directly stimulated twitch tension. Linoleic acid and linolenic acid also reduced indirectly stimulated twitch tension, whereas stearic acid, oleic acid and arachidic acid had no effect. None of three blockers of arachidonic acid metabolism, the cyclooxygenase inhibitor indomethacin, the lipoxygenase inhibitor nordihydroguaiaretic acid or the cytochrome P-450 inhibitor ketoconazole, altered the effect of arachidonic acid on twitch tension. The free radical scavenger superoxide dismutase eliminated the inhibitory effect of arachidonic acid on twitch tension, suggesting that superoxide anion played a role in arachidonic acid's action. RP USA, MED RES INST INFECT DIS, DIV TOXINOL, FREDERICK, MD 21702 USA. NR 21 TC 4 Z9 4 U1 0 U2 0 PU AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3995 USA SN 0022-3565 EI 1521-0103 J9 J PHARMACOL EXP THER JI J. Pharmacol. Exp. Ther. PD MAR PY 1993 VL 264 IS 3 BP 1311 EP 1314 PG 4 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA KT846 UT WOS:A1993KT84600040 PM 8450467 ER PT J AU LILLEY, JS AF LILLEY, JS TI REDUCED-LENGTH SCARFED-NOZZLES FOR THRUST VECTOR ADJUSTMENT SO JOURNAL OF PROPULSION AND POWER LA English DT Article AB The results of an investigation into the utilization of scarfed, truncated perfect-nozzles for thrust vector adjustment in tactical strap-on boosters is presented. The use of truncated perfect-nozzle expansion contours was evaluated as a means of achieving significant nozzle length reductions over conical nozzle designs without degrading axial thrust or thrust vector adjustment capability. Previously developed perfect-nozzle and scarfed-nozzle performance analysis computer codes were used to generate an extensive parametric study which characterized the influence of nozzle length and expansion ratio on axial thrust and thrust vector adjustment capability. Comparisons were made against the results obtained for scarfed-nozzles with conical expansion contours. The parametric study was utilized to develop a general scarfed truncated perfect-nozzle design methodology. This methodology was exercised to generate a specific reduced-length scarfed-nozzle design. The axial performance and thrust vector adjustment capability of the nozzle design was experimentally verified through solid rocket motor static firings. RP LILLEY, JS (reprint author), USA,MISSILE COMMAND,PROP DIRECTORATE,REDSTONE ARSENAL,AL 35898, USA. NR 11 TC 0 Z9 0 U1 0 U2 1 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091 SN 0748-4658 J9 J PROPUL POWER JI J. Propul. Power PD MAR-APR PY 1993 VL 9 IS 2 BP 233 EP 239 DI 10.2514/3.23614 PG 7 WC Engineering, Aerospace SC Engineering GA KR542 UT WOS:A1993KR54200012 ER PT J AU LEGGETT, DC AF LEGGETT, DC TI SOLVENT WATER PARTITIONING OF DIMETHYLMETHYLPHOSPHONATE (DMMP) AS A PROBE OF SOLVENT ACIDITY SO JOURNAL OF SOLUTION CHEMISTRY LA English DT Article DE LINEAR SOLVATION ENERGY RELATIONSHIPS; ALPHA (ALPHA); SOLVATOCHROMIC PARAMETERS; SOLVENT ACIDITY; DMMP ID SOLVATION ENERGY RELATIONSHIPS; POLARIZABILITY; COEFFICIENTS; PARAMETERS; POLARITY AB Experimentally determined partition coefficients for DMMP between NaCl-saturated water and 20 solvents were correlated using the solvatochromic parameters alpha, beta, and pi*. An inverted LSER was then used to predict a for 7 additional solvents. The new cohesion parameters alphabeta and pi*2 were found to be more representative of cavity formation than delta(H)2. Most importantly, it was essential to include either alphabeta or delta(H)2 in the LSER. The partition method appears to be a useful adjunct to solvatochromic techniques in refining and extending the a scale of solvent acidity and could be used to rationalize solvent selection in extraction processes. RP LEGGETT, DC (reprint author), DEPT ARMY,COLD REG RES & ENGN LAB,HANOVER,NH 03755, USA. NR 17 TC 13 Z9 13 U1 1 U2 4 PU PLENUM PUBL CORP PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 SN 0095-9782 J9 J SOLUTION CHEM JI J. Solut. Chem. PD MAR PY 1993 VL 22 IS 3 BP 289 EP 296 DI 10.1007/BF00649251 PG 8 WC Chemistry, Physical SC Chemistry GA KT144 UT WOS:A1993KT14400009 ER PT J AU UNDERWOOD, JH BURR, W KAPUSTA, AA RICKARD, CA AF UNDERWOOD, JH BURR, W KAPUSTA, AA RICKARD, CA TI CHARACTERIZATION OF EARLY AND MODERN WIRE FOR AN ITALIAN HARPSICHORD - CLOSURE SO JOURNAL OF TESTING AND EVALUATION LA English DT Discussion C1 HARPSICHORD MAKER,HOOSICK,NY 12089. RP UNDERWOOD, JH (reprint author), USA,CTR ARMAMENT RD&E,WATERVLIET,NY 12189, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TESTING MATERIALS PI W CONSHOHOCKEN PA 100 BARR HARBOR DR, W CONSHOHOCKEN, PA 19428-2959 SN 0090-3973 J9 J TEST EVAL JI J. Test. Eval. PD MAR PY 1993 VL 21 IS 2 BP 137 EP 138 PG 2 WC Materials Science, Characterization & Testing SC Materials Science GA LB485 UT WOS:A1993LB48500009 ER PT J AU JENSEN, PS SALZBERG, AD RICHTERS, JE WATANABE, HK AF JENSEN, PS SALZBERG, AD RICHTERS, JE WATANABE, HK TI SCALES, DIAGNOSES, AND CHILD PSYCHOPATHOLOGY .1. CBCL AND DISK RELATIONSHIPS SO JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY LA English DT Article DE DIAGNOSTIC INTERVIEW SCHEDULE FOR CHILDREN; CHILD BEHAVIOR CHECKLIST; VALIDITY; DIAGNOSTIC INTERVIEWS; SYMPTOM SCALES ID INTERVIEWS; DISORDERS; VALIDITY; ANXIETY AB Objective: To clarify the relationship between scales and structured diagnostic interview diagnoses, the authors used a two-stage screening method to study 201 military families with one or more children ages 5 to 17. Method: Parents and children were interviewed with the Diagnostic Interview Schedule for Children (DISC 2. 1); parents also completed the Child Behavior Checklist (CBCL) while the children completed other self-report symptom scales. Results: Results indicate only a modest ability of scales to discriminate among discrete DISC-derived DSM-III-diagnoses. Inclusion of diagnostic information from both parents and children resulted in more diagnoses than from either informant alone, and the additional diagnoses consisted mostly of internalizing disorders contributed by child-derived DISC information. In general, correlations were larger between scales and diagnoses within the same informant (regardless of diagnostic construct) than across informants (but within the same diagnostic construct). Child self-report measures tended to outperform the CBCL as screeners against the overall ''caseness'' criterion on the DISC. However, child self-report scales were relatively nonspecific and showed little ability to selectively identify internalizing disorders such as anxiety and/or depression. Compared with single informant diagnoses, combined-informant diagnoses were generally superior in demonstrating broader relationships to both parent and child symptom scales. Conclusions: Additional research is needed in order to build careful crosswalks between the various approaches to assessing childhood psychopathology, to decide on optimal rules for combining information to establish diagnoses, and to validate the currently available assessment alternatives. C1 WALTER REED ARMY INST RES,DIV NEUROPSYCHIAT,DEPT MIL PSYCHIAT,WASHINGTON,DC 20307. RP JENSEN, PS (reprint author), NIMH,DIV CLIN & TREATMENT RES,CHILD & ADOLESCENT DISORDERS,ROOM 10104,ROCKVILLE,MD 20857, USA. OI Jensen, Peter/0000-0003-2387-0650 NR 18 TC 100 Z9 100 U1 3 U2 6 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0890-8567 J9 J AM ACAD CHILD PSY JI J. Am. Acad. Child Adolesc. Psychiatr. PD MAR PY 1993 VL 32 IS 2 BP 397 EP 406 DI 10.1097/00004583-199303000-00022 PG 10 WC Psychology, Developmental; Pediatrics; Psychiatry SC Psychology; Pediatrics; Psychiatry GA KN981 UT WOS:A1993KN98100024 PM 8444770 ER PT J AU SMITH, KJ SKELTON, HG YEAGER, J ANGRITT, P WAGNER, KF AF SMITH, KJ SKELTON, HG YEAGER, J ANGRITT, P WAGNER, KF TI HISTOLOGIC FEATURES OF FOREIGN-BODY REACTIONS IN PATIENTS INFECTED WITH HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Article ID IMMUNE-DEFICIENCY SYNDROME; KAPOSIS SARCOMA; INTERFERON; CELLS; UNRESPONSIVENESS; INDIVIDUALS; PATTERNS; IL-10 AB Background: Within a large population of patients seropositive for human immunodeficiency virus type 1 (HIV-1), seven had biopsy specimens that showed foreign body reactions with histologic features different from those seen in non-HIV-1-positive patients. Objective: These cases were reviewed to determine whether there was a specific pattern of response to foreign bodies in HIV-1 infection and whether this pattern was related to the stage of disease. Methods. Biopsy specimens were reviewed to identify ruptured epidermal cysts. These were studied in routine hematoxylin-and-eosin-stained sections and with immunohistochemical stains to characterize the inflammatory infiltrate. Results: The lesions in HIV-1-infected patients contained abundant macrophages with evidence of decreased function and a lack of giant cells. Conclusion: These histologic features suggest an early functional deficit before there is a significant decrease in the number of T4 lymphocytes. C1 WALTER REED ARMY INST RES, WASHINGTON, DC 20307 USA. NATL NAVAL MED CTR, DEPT DERMATOL, BETHESDA, MD 20814 USA. HENRY M JACKSON FDN, BETHESDA, MD USA. RP SMITH, KJ (reprint author), ARMED FORCES INST PATHOL, DEPT DERMATOPATHOL & AIDS REGISTRY, WASHINGTON, DC 20306 USA. FU NIAMS NIH HHS [AY01AR90008, NY01AR00014] NR 24 TC 8 Z9 8 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD MAR PY 1993 VL 28 IS 3 BP 470 EP 476 PG 7 WC Dermatology SC Dermatology GA KQ326 UT WOS:A1993KQ32600015 PM 8445065 ER PT J AU BAIMAI, V RATTANARITHIKUL, R KIJCHALAO, U AF BAIMAI, V RATTANARITHIKUL, R KIJCHALAO, U TI METAPHASE KARYOTYPES OF ANOPHELES OF THAILAND AND SOUTHEAST-ASIA .1. THE HYRCANUS GROUP SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Article ID CYTOGENETIC EVIDENCE; HETEROCHROMATIN; DIRUS; CULICIDAE; COMPLEX; DIPTERA AB Metaphase karyotypes of 6 species of the Hyrcanus Species Group of the subgenus Anopheles show constitutive heterochromatin variation in X and Y chromosomes. Anopheles peditaeniatus exhibits the most extensive variation in the size and shape of heterochromatic sex chromosomes, with 3 types of X and 5 types of Y chromosomes. Anopheles nitidus shows the least variation, with only 2 types of X chromosomes. Anopheles sinensis and An. crawfordi each have 2 forms of metaphase karyotype in the heterochromatin of the Y chromosome. It is not known whether the 2 forms of metaphase karyotype in these 2 species represent inter- or intraspecific differences. The 2 forms of heterochromatic sex chromosomes observed in An. argyropus and An. nigerrimus may suggest the existence of sibling species complexes within each of these species. C1 USA,MED COMPONENT,DEPT MED ENTOMOL,ARMED FORCES RES INST MED SCI,BANGKOK 10400,THAILAND. RP BAIMAI, V (reprint author), MAHIDOL UNIV,FAC SCI,DEPT BIOL,RAMA 6 RD,BANGKOK 10400,THAILAND. NR 23 TC 28 Z9 31 U1 0 U2 0 PU AMER MOSQUITO CONTROL ASSN INC PI LAKE CHARLES PA 707-A EAST PRIEN LAKE ROAD, PO BOX 5416, LAKE CHARLES, LA 70606-5416 SN 8756-971X J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD MAR PY 1993 VL 9 IS 1 BP 59 EP 67 PG 9 WC Entomology SC Entomology GA KW008 UT WOS:A1993KW00800010 PM 8468575 ER PT J AU WHITTLE, RK LINTHICUM, KJ THANDE, PC WAGATI, JN KAMAU, CM ROBERTS, CR AF WHITTLE, RK LINTHICUM, KJ THANDE, PC WAGATI, JN KAMAU, CM ROBERTS, CR TI EFFECT OF CONTROLLED BURNING ON SURVIVAL OF FLOODWATER AEDES EGGS IN KENYA SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Article ID VALLEY FEVER VIRUS; DIPTERA; DAMBO; FORMULATION; METHOPRENE; CULICIDAE AB The effect of controlled burning on the survival of Aedes mosquito eggs was evaluated in 2 distinct dambo habitats. In a dambo dominated by grasses, egg survival was 3.3% after burning compared with 43.8% in a similar dambo that was not burned. In a dambo dominated by sedges, egg survival was 0.7% after burning compared with 28.5% in a similar dambo that was not burned. Mortality of mosquito eggs appeared to be caused by high temperatures associated with the fire and not elapsed time since egg survival did not decrease with time after burning. The potential for burning to control the mosquito vectors of Rift Valley fever virus is discussed. C1 USA,MED RES INST INFECT DIS,FREDERICK,MD 21702. NR 13 TC 5 Z9 5 U1 0 U2 4 PU AMER MOSQUITO CONTROL ASSN INC PI LAKE CHARLES PA 707-A EAST PRIEN LAKE ROAD, PO BOX 5416, LAKE CHARLES, LA 70606-5416 SN 8756-971X J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD MAR PY 1993 VL 9 IS 1 BP 72 EP 77 PG 6 WC Entomology SC Entomology GA KW008 UT WOS:A1993KW00800012 PM 8468577 ER PT J AU FLEMISH, JR JONES, KA AF FLEMISH, JR JONES, KA TI SELECTIVE WET ETCHING OF GALNP, GAAS, AND INP IN SOLUTIONS OF HCL, CH3COOH, AND H2O2 SO JOURNAL OF THE ELECTROCHEMICAL SOCIETY LA English DT Article ID CIRCUITS; DIODES AB The wet chemical etching of GaInP, GaAs, and InP in solutions of HCI:CH3COOH:H2O2 has been evaluated. In the absence of the oxidant, H2O2, the solutions etch InP and GaInP with high selectively over GaAs but rough surfaces are formed. When H2O2 is added, smoother surfaces are obtained and depending on the H2O2 concentration, the etchant can be made highly selective for GaAs. The etch rate of these mixtures varies strongly with the age of the solution, initially increasing and then gradually declining. The increase in etch rate is attributed to the formation Of Cl2 in solution from the reaction of HCI with H2O2, and the eventual decrease in etch rate to the gradual evaporation of Cl2 from solution. The CH3COOH in these mixtures functions as a nonaqueous solvent. In dilute solutions (1 HCl: y CH3COOH: 1 H2O2, with y greater-than-or-equal-to 20) slow etch rates and smooth surfaces can be obtained for all three materials, suggesting that this etchant may be useful for recessing layers for heterostructure electronic and optoelectronic device applications. RP FLEMISH, JR (reprint author), USA,ELECTR TECH & DEVICES LAB,FT MONMOUTH,NJ 07703, USA. NR 14 TC 23 Z9 23 U1 0 U2 11 PU ELECTROCHEMICAL SOC INC PI PENNINGTON PA 10 SOUTH MAIN STREET, PENNINGTON, NJ 08534 SN 0013-4651 J9 J ELECTROCHEM SOC JI J. Electrochem. Soc. PD MAR PY 1993 VL 140 IS 3 BP 844 EP 847 DI 10.1149/1.2056170 PG 4 WC Electrochemistry; Materials Science, Coatings & Films SC Electrochemistry; Materials Science GA KT622 UT WOS:A1993KT62200058 ER PT J AU GROW, JM LEVY, RA SHI, YT PFEFFER, RL AF GROW, JM LEVY, RA SHI, YT PFEFFER, RL TI LOW-PRESSURE CHEMICAL VAPOR-DEPOSITION OF SILICON-CARBIDE FROM DIETHYLSILANE SO JOURNAL OF THE ELECTROCHEMICAL SOCIETY LA English DT Article ID GAS AB This study investigates the use of diethylsilane as a single precursor to synthesize by low pressure chemical vapor deposition of amorphous SiC films. At 700-degrees-C, the deposition rate was observed to vary linearly with flow rate and pressure while the stoichiometry of the deposits showed little deviation from a composition of Si0.6C0.4. In the 600 to 700-degrees-C range, the growth rate was observed to follow an Arrhenius behavior with an activation energy of 41 kcal/mol. The elemental composition became progressively richer in carbon as the deposition temperature increased. The films were found to remain amorphous until the deposition temperature of 850-degrees-C where the onset of crystallinity to a beta-SiC phase occurred. While remaining tensile for all deposition conditions, the hardness and Young's modulus of the amorphous films increased with higher temperatures reaching values of 33 and 250 GPa near the stoichiometric composition. C1 USA,ETDL,FT MONMOUTH,NJ 07703. RP GROW, JM (reprint author), NEW JERSEY INST TECHNOL,UNIV HTS,NEWARK,NJ 07102, USA. NR 14 TC 21 Z9 21 U1 2 U2 5 PU ELECTROCHEMICAL SOC INC PI PENNINGTON PA 10 SOUTH MAIN STREET, PENNINGTON, NJ 08534 SN 0013-4651 J9 J ELECTROCHEM SOC JI J. Electrochem. Soc. PD MAR PY 1993 VL 140 IS 3 BP 851 EP 854 DI 10.1149/1.2056172 PG 4 WC Electrochemistry; Materials Science, Coatings & Films SC Electrochemistry; Materials Science GA KT622 UT WOS:A1993KT62200060 ER PT J AU SILBERBERG, A BAUMAN, R HURSH, S AF SILBERBERG, A BAUMAN, R HURSH, S TI STOCK OPTIMIZING - MAXIMIZING REINFORCERS PER SESSION ON A VARIABLE-INTERVAL SCHEDULE SO JOURNAL OF THE EXPERIMENTAL ANALYSIS OF BEHAVIOR LA English DT Article DE ECONOMICS; STOCK OPTIMIZING; INCOME MAXIMIZING; VARIABLE-INTERVAL SCHEDULE; TOKENS; KEY PRESS; TOKEN DEPOSIT; MONKEYS ID BEHAVIOR; PIGEONS; CHOICE; FOOD AB In Experiment 1, 2 monkeys earned their daily food ration by pressing a key that delivered food according to a variable-interval 3-min schedule. In Phases 1 and 4, sessions ended after 3 hr. In Phases 2 and 3, sessions ended after a fixed number of responses that reduced food intake and body weights from levels during Phases 1 and 4. Monkeys responded at higher rates and emitted more responses per food delivery when the food earned in a session was reduced. In Experiment 2, monkeys earned their daily food ration by depositing tokens into the response panel. Deposits delivered food according to a variable-interval 3-min schedule. When the token supply was unlimited (Phases 1, 3, and 5), sessions ended after 3 hr. In Phases 2 and 4, sessions ended after 150 tokens were deposited, resulting in a decrease in food intake and body weight. Both monkeys responded at lower rates and emitted fewer responses per food delivery when the food earned in a session was reduced. Experiment 1's results are consistent with a strength account, according to which the phases that reduced body weights increased food's value and therefore increased subjects' response rates. The results of Experiment 2 are consistent with an optimizing strategy, because lowering response rates when food is restricted defends body weight on variable-interval schedules. These contrasting results may be attributed to the discriminability of the contingency between response number and the end of a session being greater in Experiment 2 than in Experiment 1. In consequence, subjects lowered their response rates in order to increase the number of reinforcers per session (stock optimizing). C1 WALTER REED ARMY INST RES,WASHINGTON,DC 20307. RP SILBERBERG, A (reprint author), AMERICAN UNIV,DEPT PSYCHOL,WASHINGTON,DC 20016, USA. NR 24 TC 3 Z9 3 U1 0 U2 0 PU SOC EXP ANALYSIS BEHAVIOR INC PI BLOOMINGTON PA INDIANA UNIV DEPT PSYCHOLOGY, BLOOMINGTON, IN 47405 SN 0022-5002 J9 J EXP ANAL BEHAV JI J. Exp. Anal. Behav. PD MAR PY 1993 VL 59 IS 2 BP 389 EP 399 DI 10.1901/jeab.1993.59-389 PG 11 WC Psychology, Biological; Behavioral Sciences; Psychology, Experimental SC Psychology; Behavioral Sciences GA KQ288 UT WOS:A1993KQ28800010 PM 8454960 ER PT J AU SAKANO, T OKERBERG, CV SHIPPEE, RL SANCHEZ, J MASON, AD PRUITT, BA AF SAKANO, T OKERBERG, CV SHIPPEE, RL SANCHEZ, J MASON, AD PRUITT, BA TI A RABBIT MODEL OF INHALATION INJURY SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article ID LUNG WATER CHANGES; SMOKE INHALATION; MORTALITY; FIRES; SHEEP AB In the course of developing a model of inhalation injury, the relationship between the severity of pulmonary injury and specific techniques and doses of smoke exposure was examined in pairs of rabbits simultaneously exposed to smoke. In group I (5 pairs), one animal in each pair was exposed to smoke with a breath hold (BH) at the end of each exposure; the second animal received an exposure producing the same level of carboxyhemoglobin without BH. In group II (6 pairs), both animals were exposed to 25 units of smoke simultaneously, with BH. In group III (3 pairs), one animal received a 20-unit exposure and the other a 25-unit exposure, both with BH. In group IV, 9 animals received 25-unit exposures with BH and were observed for 4 days. Groups V and VI served as controls. Smoke exposure with BH regularly produced severe injury in terms of decreased PaO2 and histopathologic changes, while exposure without BH did not, despite high levels of carboxyhemoglobin after smoke inhalation. The mean differences in percent residual PaO2 (PaO2 at 48 hours x 100/pre-injury PaO2) and in extravascular lung water (EVLW) at 48 hours within pairs of animals receiving 25 units with BH were 12.3% +/- 5.33%, and 0.271 +/- 0.157 mL/g, respectively. Histologic findings such as necrotic tracheobronchitis with pseudomembrane were consistently present. No differences were observed between animals receiving exposures of 20 and 25 units. During the 4 days of observation, three animals in group IV died. PaO2 was lowest on the second day and rose thereafter in all surviving animals except in one that had massive pneumonia Extravascular lung water levels were still elevated on the fourth day after injury. Histologically, the destroyed surface epithelium in the airway was covered by a nonciliated epithelium, and focal pneumonia was found frequently in the pulmonary parenchyma. These results indicate an advantage of the extended exposure afforded by BH in creating consistent, severe injury and the important part played by pneumonia in determining prognosis beyond the second postinjury day. The model appears useful for evaluating the effects of inhalation injury with concurrent cutaneous bum or wound infection, and for assessing various regimens for the treatment of inhalation injury. RP SAKANO, T (reprint author), USA,INST SURG RES,BLDG 2653,FT SAM HOUSTON,TX 78234, USA. NR 25 TC 5 Z9 5 U1 1 U2 2 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 1079-6061 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD MAR PY 1993 VL 34 IS 3 BP 411 EP 416 DI 10.1097/00005373-199303000-00018 PG 6 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA KZ702 UT WOS:A1993KZ70200019 PM 8483184 ER PT J AU MCLANE, GF MEYYAPPAN, M LEE, HS COLE, MW ECKART, DW LAREAU, RT NAMAROFF, M SASSERATH, J AF MCLANE, GF MEYYAPPAN, M LEE, HS COLE, MW ECKART, DW LAREAU, RT NAMAROFF, M SASSERATH, J TI MAGNETRON REACTIVE ION ETCHING OF GAAS IN A BCL3 DISCHARGE SO JOURNAL OF VACUUM SCIENCE & TECHNOLOGY B LA English DT Note AB Magnetron reactive ion etching (MIE) of GaAs has been investigated using BCl3 as the etch gas. Etch rates are determined as a function of applied power density (0.16-0.80 W/cm2) and chamber pressure (2-6 mTorr). Patterned GaAs samples were etched anisotropically and exhibited smooth surfaces, with no indication of residues on surfaces or sidewalls. Transmission electron microscope measurements were performed to determine etch induced wafer damage. Schottky diode measurements on etched surfaces revealed minimal degradation of surface region electrical properties. Our results show that (MIE) in BCl3 is an attractive processing technique for GaAs device fabrication. C1 SCI RES ASSOCIATES INC,GLASTONBURY,CT 06033. MAT RES CORP,ORANGEBURG,NY 10962. RP MCLANE, GF (reprint author), USA,RES LAB,FT MONMOUTH,NJ 07703, USA. NR 8 TC 10 Z9 10 U1 0 U2 1 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 1071-1023 J9 J VAC SCI TECHNOL B JI J. Vac. Sci. Technol. B PD MAR-APR PY 1993 VL 11 IS 2 BP 333 EP 336 DI 10.1116/1.586679 PG 4 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Physics, Applied SC Engineering; Science & Technology - Other Topics; Physics GA KY050 UT WOS:A1993KY05000034 ER PT J AU KIM, JM CARR, WN ZETO, RJ AF KIM, JM CARR, WN ZETO, RJ TI FABRICATION AND CHARACTERIZATION OF LATERAL CUSP-EDGE AND KNIFE-EDGE GEOMETRY CATHODES SO JOURNAL OF VACUUM SCIENCE & TECHNOLOGY B LA English DT Article; Proceedings Paper CT 5TH INTERNATIONAL VACUUM MICROELECTRONICS CONF CY JUL 13-17, 1992 CL VIENNA, AUSTRIA SP AMER VACUUM SOC, NATL SCI FDN, USN, OFF NAVAL RES, EUROPEAN OFF, USA, RES & DEV STANDARDIZAT GRP, SIEMENS DEUTSCHLAND, BUNDESMINIST WISSENSCH & FORSCH, OSTERREICH FORSCHUNGSGEMEINSCH, WIENER TOURISMUSVERBAND, SIEMENS OSTERRICH ID FIELD-EMISSION AB Two lift-off techniques are demonstrated to form lateral field emission cathodes by shadowing a sputter deposition for tungsten composite. A current of 26 muA is observed for ''knife-edge'' cathodes of 23 mum edge length. The I-V characteristics are consistent with the Fowler-Nordheim relationship. The effect of focusing electrodes for increasing anode collection efficiency is consistent with our electron trajectory tracing simulations. The fabrication process for these devices is described in detail. C1 NEW JERSEY INST TECHNOL,MICROELECTR RES CTR,NEWARK,NJ 07102. USA,RES LAB,FT MONMOUTH,NJ 07703. RP KIM, JM (reprint author), FED CORP,RES TRIANGLE PK,NC 27709, USA. NR 16 TC 8 Z9 8 U1 0 U2 2 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 1071-1023 J9 J VAC SCI TECHNOL B JI J. Vac. Sci. Technol. B PD MAR-APR PY 1993 VL 11 IS 2 BP 459 EP 463 DI 10.1116/1.586884 PG 5 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Physics, Applied SC Engineering; Science & Technology - Other Topics; Physics GA KY050 UT WOS:A1993KY05000063 ER PT J AU DEVANTIER, BA FELDMAN, AD AF DEVANTIER, BA FELDMAN, AD TI REVIEW OF GIS APPLICATIONS IN HYDROLOGIC MODELING SO JOURNAL OF WATER RESOURCES PLANNING AND MANAGEMENT-ASCE LA English DT Article ID DIGITAL ELEVATION DATA; SURFACE; EXTRACTION; NETWORKS; SYSTEM; RUNOFF AB Geographic information systems (GIS) provide a digital representation of watershed characteristics used in hydrologic modeling. This paper summarizes past efforts and current trends in using digital terrain models and GIS to perform hydrologic analyses. Three methods of geographic information storage are discussed: raster or grid, triangulated irregular network, and contour-based line networks. The computational, geographic, and hydrologic aspects of each data-storage method are analyzed. The use of remotely sensed data in GIS and hydrologic modeling is reviewed. Lumped parameter, physics-based, and hybrid approaches to hydrologic modeling are discussed with respect to their geographic data inputs. Finally, several applications areas (e.g., floodplain hydrology, and erosion prediction) for GIS hydrology are described. C1 USA,CORPS ENGINEERS,CTR HYDROL ENGN,DIV RES,DAVIS,CA 95616. RP DEVANTIER, BA (reprint author), SO ILLINOIS UNIV,CARBONDALE,IL 62901, USA. NR 71 TC 64 Z9 66 U1 1 U2 14 PU ASCE-AMER SOC CIVIL ENGINEERS PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-9496 J9 J WATER RES PL-ASCE JI J. Water Resour. Plan. Manage.-ASCE PD MAR-APR PY 1993 VL 119 IS 2 BP 246 EP 261 DI 10.1061/(ASCE)0733-9496(1993)119:2(246) PG 16 WC Engineering, Civil; Water Resources SC Engineering; Water Resources GA KN715 UT WOS:A1993KN71500009 ER PT J AU SCOTT, SH AF SCOTT, SH TI UNCERTAINTY ANALYSIS OF DREDGE-PRODUCTION MEASUREMENT AND CALCULATION SO JOURNAL OF WATERWAY PORT COASTAL AND OCEAN ENGINEERING-ASCE LA English DT Article AB The accurate measurement of dredge production contributes to the overall efficiency and cost-effectiveness of the dredging process. The use of production measurement systems on pipeline and hopper dredges provides dredging personnel with tools for measuring and monitoring production quantities. The accuracy of these production monitoring systems varies according to the instrumentation used and the knowledge of the sediment and water properties associated with the dredging activity. Each measurement and physical quantity associated with the calculation of dredging quantities has some uncertainty associated with it. The equations for calculating production are functions of multiple variables, each contributing some uncertainty to the final calculation. A general uncertainty analysis is applied to dredge-production measurements and calculations. Equations describing production for hopper and pipeline dredges are reduced to uncertainty expressions using the uncertainty analysis technique. Example calculations are performed to demonstrate the uncertainty potential in production calculations. RP SCOTT, SH (reprint author), USA,ENGN WATERWAYS EXPTL STN,CEWES-HE-E,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 3 TC 2 Z9 2 U1 0 U2 0 PU ASCE-AMER SOC CIVIL ENGINEERS PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-950X J9 J WATERW PORT C-ASCE JI J. Waterw. Port Coast. Ocean Eng.-ASCE PD MAR-APR PY 1993 VL 119 IS 2 BP 193 EP 203 DI 10.1061/(ASCE)0733-950X(1993)119:2(193) PG 11 WC Engineering, Civil; Engineering, Ocean; Water Resources SC Engineering; Water Resources GA KP648 UT WOS:A1993KP64800005 ER PT J AU DARYOUSH, AS SAMANT, N RHODES, D STURZBECHER, D AF DARYOUSH, AS SAMANT, N RHODES, D STURZBECHER, D TI PHOTONIC CAD FOR HIGH-SPEED FIBEROPTIC LINKS SO MICROWAVE JOURNAL LA English DT Article ID CIRCUIT; NOISE C1 USA,MICROWAVE LIGHTWAVE BRANCH,ARL,EPSD,FT MONMOUTH,NJ 07703. USA,LAB COM,ELECTR DEVICES & TECHNOL LABS,FT MONMOUTH,NJ 07703. RP DARYOUSH, AS (reprint author), DREXEL UNIV,CTR MICROWAVE LIGHTWAVE ENGN,PHILADELPHIA,PA 19104, USA. NR 16 TC 0 Z9 0 U1 0 U2 0 PU HORIZON HOUSE-MICROWAVE PI NORWOOD PA 685 CANTON ST, NORWOOD, MA 02062 SN 0192-6225 J9 MICROWAVE J JI Microw. J. PD MAR PY 1993 VL 36 IS 3 BP 58 EP & PG 0 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA KU573 UT WOS:A1993KU57300002 ER PT J AU NORTON, AR AF NORTON, AR TI THE FUTURE OF CIVIL SOCIETY IN THE MIDDLE-EAST SO MIDDLE EAST JOURNAL LA English DT Article RP NORTON, AR (reprint author), US MIL ACAD,DEPT SOCIAL SCI,W POINT,NY 10996, USA. NR 25 TC 20 Z9 20 U1 0 U2 0 PU MIDDLE EAST INSTITUTE PI WASHINGTON PA 1761 N STREET NW, CIRCULATION DEPT, WASHINGTON, DC 20036-2882 SN 0026-3141 J9 MIDDLE EAST J JI Middle East J. PD SPR PY 1993 VL 47 IS 2 BP 205 EP 216 PG 12 WC Area Studies SC Area Studies GA KZ395 UT WOS:A1993KZ39500001 ER PT J AU PETERSON, PM AF PETERSON, PM TI CIVILIAN DEMONSTRATIONS NEAR THE MILITARY INSTALLATION - RESTRAINTS ON MILITARY SURVEILLANCE AND OTHER INTELLIGENCE ACTIVITIES SO MILITARY LAW REVIEW LA English DT Article RP PETERSON, PM (reprint author), USA,JUDGE ADVOCATES GEN SCH,DIV ADM & CIVIL LAW,WASHINGTON,DC 20310, USA. NR 25 TC 1 Z9 1 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD SPR PY 1993 VL 140 BP 113 EP 178 PG 66 WC Law SC Government & Law GA MC670 UT WOS:A1993MC67000003 ER PT J AU PALMER, WD AF PALMER, WD TI TIME TO EXORCISE ANOTHER GHOST FROM THE VIETNAM-WAR - RESTRUCTURING THE IN-SERVICE CONSCIENTIOUS-OBJECTOR PROGRAM SO MILITARY LAW REVIEW LA English DT Article ID RELIGION; CONSTITUTION RP PALMER, WD (reprint author), US DISCIPLINARY BARRACKS,FT LEAVENWORTH,KS, USA. NR 70 TC 3 Z9 3 U1 1 U2 1 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD SPR PY 1993 VL 140 BP 179 EP 247 PG 69 WC Law SC Government & Law GA MC670 UT WOS:A1993MC67000004 ER PT J AU ABBOTT, K BARR, J FASCIANO, A GOUGE, S AF ABBOTT, K BARR, J FASCIANO, A GOUGE, S TI EVALUATION OF GENDER DIFFERENCES IN URINE SPECIFIC-GRAVITY AND SERUM ELECTROLYTES IN RESPONSE TO VARIED FLUID INTAKE AND IBUPROFEN USE SO MILITARY MEDICINE LA English DT Article AB Heat casualties and other conditions related to suboptimal fluid intake (FI) are common in the military. Current methods to assess FI do not address gender differences or medication use, specifically non-steroidal anti-inflammatory drugs (NSAIDs), which are commonly used in the field. Nine men and six women were prospectively studied while stationed in Saudi Arabia. Urine specific gravity and serum electrolytes were monitored as FI was varied before and after daily ibuprofen (IBP) ingestion. IBP impaired urinary dilution in both men and women, but differences were not statistically significant pre- and post-IBP or between genders. Use of IBP or other NSAIDs may confound usual methods to ensure adequate FI, and soldiers should be specifically questioned about their use before such assessments. RP ABBOTT, K (reprint author), BROOKE ARMY MED CTR,DIV NEPHROL,FT SAM HOUSTON,TX 78234, USA. OI Abbott, Kevin/0000-0003-2111-7112 NR 0 TC 2 Z9 2 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAR PY 1993 VL 158 IS 3 BP 131 EP 135 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA KR895 UT WOS:A1993KR89500002 PM 8487961 ER PT J AU BIELENDA, CC KNAPIK, J WRIGHT, DA AF BIELENDA, CC KNAPIK, J WRIGHT, DA TI PHYSICAL-FITNESS AND CARDIOVASCULAR-DISEASE RISK-FACTORS OF FEMALE SENIOR UNITED-STATES MILITARY OFFICERS AND FEDERAL-EMPLOYEES SO MILITARY MEDICINE LA English DT Article AB This study compared physical fitness and cardiovascular risk factors between military officers (N = 23) and civilians (N = 17). Subjects were women (average age 43 years) who attended the U.S. Army War College from 1986-1991. Officers had less body fat, higher aerobic capacity, lower resting heart rates, lower resting diastolic blood pressure, higher HDL, and marginally lower triglycerides. Female military officers appear to be more fit and have lower cardiovascular risk factors than their civilian counterparts. RP BIELENDA, CC (reprint author), USA,COLL WAR,ARMY PHYS FITNESS RES INST,ROOT HALL,CARLISLE,PA 17013, USA. NR 0 TC 11 Z9 11 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAR PY 1993 VL 158 IS 3 BP 177 EP 181 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA KR895 UT WOS:A1993KR89500013 PM 8487972 ER PT J AU MORITZ, D COPELAND, RL VERNALIS, MN RICE, BJ CALAGAN, JL COOK, JP AF MORITZ, D COPELAND, RL VERNALIS, MN RICE, BJ CALAGAN, JL COOK, JP TI THE SHORTENED ADVANCED COURSE FOR ARMY PHYSICIANS SO MILITARY MEDICINE LA English DT Article AB The Army uses a series of career courses to prepare officers for progressive assignments. These courses have not been widely utilized by Army physicians. To improve the military education of physicians, an abbreviated Advanced Course was developed by the Academy of Health Science. A study of this course by the physicians attending its first offering showed that 8 weeks was an appropriate length. Information is provided to help improve the course and encourage attendance by Army physicians. This course will likely become mandatory and will be a key element in the training of all Army physicians. RP MORITZ, D (reprint author), BROOKE ARMY MED CTR,DEPT SURG,CARDIOTHORAC SURG SERV,FT SAM HOUSTON,TX 78234, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAR PY 1993 VL 158 IS 3 BP 183 EP 189 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA KR895 UT WOS:A1993KR89500015 PM 8098143 ER PT J AU VIOLA, JM HICKS, R PORTER, T AF VIOLA, JM HICKS, R PORTER, T TI GULF-WAR VETERANS WITH PTSD SO MILITARY MEDICINE LA English DT Letter RP VIOLA, JM (reprint author), TRIPLER ARMY MED CTR,3B2 PSYCHIAT,HONOLULU,HI 96819, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAR PY 1993 VL 158 IS 3 BP A4 EP A4 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA KR895 UT WOS:A1993KR89500001 PM 8487960 ER PT J AU RUFFIN, PB SUNG, CC AF RUFFIN, PB SUNG, CC TI TEMPERATURE EFFECT ON THE PERFORMANCE OF POLARIZATION-MAINTAINING FIBERS SO OPTICAL ENGINEERING LA English DT Article DE POLARIZATION-MAINTAINING FIBERS; FIBER OPTIC GYROS AB The cross coupling of the polarization modes of polarization-maintaining fibers is measured in a temperature control chamber. The temperature dependence of the extinction ratio is analyzed in terms of a steady temperature gradient and a fluctuating component that are experimentally controlled. The consistency of the experimental results with the theoretical analysis in this study can be used to limit the applications of fibers to specific desirable designs. Temperature range for the required accuracy is also addressed. C1 UNIV ALABAMA,DEPT PHYS,HUNTSVILLE,AL 35899. RP RUFFIN, PB (reprint author), USA,MISSILE COMMAND RES,CTR DEV & ENGN,REDSTONE ARSENAL,AL 35898, USA. NR 8 TC 5 Z9 8 U1 1 U2 5 PU SOC PHOTO-OPT INSTRUM ENG PI BELLINGHAM PA PO BOX 10, BELLINGHAM, WA 98227-0010 SN 0091-3286 J9 OPT ENG JI Opt. Eng. PD MAR PY 1993 VL 32 IS 3 BP 476 EP 480 DI 10.1117/12.61036 PG 5 WC Optics SC Optics GA KQ388 UT WOS:A1993KQ38800007 ER PT J AU TANONE, A ZHANG, Z UANG, CM YU, FTS GREGORY, DA AF TANONE, A ZHANG, Z UANG, CM YU, FTS GREGORY, DA TI PHASE MODULATION DEPTH FOR A REAL-TIME KINOFORM USING A LIQUID-CRYSTAL TELEVISION SO OPTICAL ENGINEERING LA English DT Article DE KINOFORMS; LIQUID CRYSTAL TELEVISION; MODULATION DEPTH ID IMAGE-RECONSTRUCTION; ONLY MODULATION; COMPUTER; QUANTIZATION AB Interest in the liquid crystal television (LCTV) kinoform has been reported recently by several investigators. The technique requires a modulation depth of about 2pi, which most of the commercially available LCTVs cannot attain. We discuss an experimental study of generating an LCTV kinoform in which the the modulation depth is limited by pi. The major drawbacks of the pi phase variation are that, compared with 2pi variation, it reduces the diffraction efficiency as well as the space bandwidth product to a degree of about one-fourth. Verification of these findings is reported. C1 USA,MISSILE COMMAND,REDSTONE ARSENAL,AL 35898. UNIV ALABAMA,BIRMINGHAM,AL 35294. RP TANONE, A (reprint author), PENN STATE UNIV,DEPT ELECT & COMP ENGN,UNIV PK,PA 16802, USA. NR 19 TC 25 Z9 26 U1 0 U2 1 PU SOC PHOTO-OPT INSTRUM ENG PI BELLINGHAM PA PO BOX 10, BELLINGHAM, WA 98227-0010 SN 0091-3286 J9 OPT ENG JI Opt. Eng. PD MAR PY 1993 VL 32 IS 3 BP 517 EP 521 DI 10.1117/12.61038 PG 5 WC Optics SC Optics GA KQ388 UT WOS:A1993KQ38800014 ER PT J AU XIE, JG RUEKGAUER, TE ARMSTRONG, RL PINNICK, RG AF XIE, JG RUEKGAUER, TE ARMSTRONG, RL PINNICK, RG TI SUPPRESSION OF STIMULATED RAMAN-SCATTERING FROM MICRODROPLETS BY SEEDING WITH NANOMETER-SIZED LATEX-PARTICLES SO OPTICS LETTERS LA English DT Article ID MORPHOLOGY-DEPENDENT RESONANCES; LASER-EMISSION; DROPLETS; TIME; WATER AB Stimulated Raman scattering (SRS) in laser-irradiated microdroplets is suppressed by the addition of nanometer-sized latex particles. The microdroplets consist of either pure ethanol or a solution of Rhodamine 6G dye in ethanol, seeded with latex particles having diameters of 50 < d < 500 nm. SRS emission occurs at droplet morphology-dependent resonances (MDR's) after either direct pumping by the incident 532-nm laser or indirectly whereby the pump laser first initiates dye lasing, which in tum pumps SRS. For large latex, we observe SRS suppression at a near-coincident threshold concentration independent of the presence of dye, whereas, for small latex, adding dye reduces the-threshold, concentration by more than an order of magnitude. These findings are consistent with the interpretation that for large latex approximately 1 particle must occupy the MDR mode volume at threshold, whereas for small latex the addition of particles facilitates Forster-assisted annihilation of both 532-nm and dye-lasing MDR pump photons. C1 USA,RES LAB,WHITE SANDS MISSILE RANGE,NM 88002. RP XIE, JG (reprint author), NEW MEXICO STATE UNIV,DEPT PHYS,LAS CRUCES,NM 88003, USA. NR 18 TC 34 Z9 34 U1 0 U2 1 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0146-9592 J9 OPT LETT JI Opt. Lett. PD MAR 1 PY 1993 VL 18 IS 5 BP 340 EP 342 DI 10.1364/OL.18.000340 PG 3 WC Optics SC Optics GA KN040 UT WOS:A1993KN04000006 PM 19802129 ER PT J AU YANG, X LINDMAYER, J WRIGLEY, CY GREGORY, DA AF YANG, X LINDMAYER, J WRIGLEY, CY GREGORY, DA TI COMPACT JOINT TRANSFORM CORRELATOR USING ELECTRON TRAPPING SPATIAL LIGHT-MODULATOR SO OPTIK LA English DT Article ID 2-DIMENSIONAL ASSOCIATIVE MEMORY; PATTERN-RECOGNITION AB A compact joint transform correlator with a folded structure is proposed. The square law detection as well as light modulation in spectrum plane are performed by a novel electron trapping spatial light modulator. C1 USA, MISSILE COMMAND, REDSTONE ARSENAL, AL 35898 USA. RP QUANTEX CORP, 2 RES COURT, ROCKVILLE, MD 20850 USA. NR 10 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER GMBH, URBAN & FISCHER VERLAG PI JENA PA OFFICE JENA, P O BOX 100537, 07705 JENA, GERMANY SN 0030-4026 J9 OPTIK JI Optik PD MAR PY 1993 VL 93 IS 1 BP 35 EP 36 PG 2 WC Optics SC Optics GA KQ390 UT WOS:A1993KQ39000007 ER PT J AU JONES, RG BASS, JW AF JONES, RG BASS, JW TI FEBRILE CHILDREN WITH NO FOCUS OF INFECTION - A SURVEY OF THEIR MANAGEMENT BY PRIMARY CARE PHYSICIANS SO PEDIATRIC INFECTIOUS DISEASE JOURNAL LA English DT Article DE INFANTS; FEVER; ANTIBIOTIC TREATMENT AB We mailed a checklist survey to 1600 randomly selected pediatricians, family practice physicians (FPPs) and emergency medicine physicians (EMPs) in the United States regarding their management of children with high fever and no focus of infection at various ages: 3 weeks; 7 weeks; 4 months; and 16 months. Completed questionnaires were returned by 211 of 600 (35.2%) pediatricians, 145 of 500 (29%) FPPs and 141 of 500 (28.2%) EMPs. Most pediatricians, FPPs and EMPs would hospitalize a 3- or 7-week-old infant with fever and most pediatricians and FPPs would treat infants of this age group empirically with antibiotics. Most pediatricians, FPPs and EMPs would not hospitalize a 4-month-old or a 16-month-old with high fever with no focus of infection but 44 and 25% of pediatricians, 38 and 24% of FPPs and 41 and 34% of EMPs, respectively, would treat a 4- and 16-month-old child with high fever and no focus of infection with antibiotics. The preferred antibiotic treatment for hospitalized 3- and 7-week-old infants was ampicillin plus gentamicin or ampicillin plus cefotaxime; for older outpatients preferred treatment was amoxicillin or ceftriaxone. We conclude that hospitalization and empiric antibiotic treatment of very young infants (<2 months of age) with high fever and no focus of infection are preferred by most of the pediatricians, FPPs and EMPs surveyed. Nearly one-half of these physicians would treat 4-month-olds and a fourth would treat 16-month-olds with high fever and no focus of infection with antibiotics as outpatients. C1 TRIPLER ARMY MED CTR,DEPT PEDIAT,HONOLULU,HI 96859. NR 8 TC 41 Z9 43 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0891-3668 J9 PEDIATR INFECT DIS J JI Pediatr. Infect. Dis. J. PD MAR PY 1993 VL 12 IS 3 BP 179 EP 183 DI 10.1097/00006454-199303000-00001 PG 5 WC Immunology; Infectious Diseases; Pediatrics SC Immunology; Infectious Diseases; Pediatrics GA KQ953 UT WOS:A1993KQ95300001 PM 8451092 ER PT J AU ROSCELLI, JD AF ROSCELLI, JD TI FAMILIAL VESICOURETERAL REFLUX SO PEDIATRICS LA English DT Letter RP ROSCELLI, JD (reprint author), BROOKE ARMY MED CTR,DEPT PEDIAT NEPHROL,FT SAM HOUSTON,TX 78234, USA. NR 6 TC 0 Z9 1 U1 0 U2 0 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD, ELK GROVE VILLAGE, IL 60007-1098 SN 0031-4005 J9 PEDIATRICS JI Pediatrics PD MAR PY 1993 VL 91 IS 3 BP 678 EP 679 PG 2 WC Pediatrics SC Pediatrics GA KP638 UT WOS:A1993KP63800038 PM 8441585 ER PT J AU SHIH, TM CAPACIO, BR COOK, LA AF SHIH, TM CAPACIO, BR COOK, LA TI EFFECTS OF ANTICHOLINERGIC ANTIPARKINSONIAN DRUGS ON STRIATAL NEUROTRANSMITTER LEVELS OF RATS INTOXICATED WITH SOMAN SO PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR LA English DT Article DE SOMAN; ORGANOPHOSPHORUS COMPOUNDS; CHOLINESTERASE INHIBITORS; CONVULSIONS; ANTICONVULSANTS; ANTICHOLINERGIC COMPOUNDS; ANTIPARKINSONIAN DRUGS; ACETYLCHOLINE; CATECHOLAMINES; DOPAMINE METABOLISM ID CEREBRAL CORTICAL SLICES; INDUCED SEIZURE ACTIVITY; CHOLINESTERASE INHIBITION; ACETYLCHOLINE-RELEASE; BRAIN ACETYLCHOLINE; NERVE AGENTS; DIAZEPAM; ATROPINE; PRETREATMENT; CONVULSIONS AB Antimuscarinic drugs possessing antiparkinson activity that were effective in preventing convulsions induced by the organophosphorus cholinesterase (ChE) inhibitor soman were studied for their effects on spinal cord ChE activity and striatal levels of acetylcholine (ACh) and catecholamines in soman-intoxicated rats. Either biperiden (BPR) or trihexyphenidyl (THP) was administered to rats at an anticonvulsant dose (0.125 mg/kg, IM) in the presence or absence of soman (100 mug/kg, SC). The time course (up to 2 h) for ChE activity and levels of ACh and catecholamines were measured after soman, BPR, THP, soman and BPR, or soman and THP treatment. Soman rapidly inhibited ChE activity (65-75%; 15-120 min) and increased ACh levels (35%; at 30 min). It did not affect norepinephrine or dopamine (DA), but elevated at later time points (60-120 min) levels of the DA metabolites, 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA), thus indicating increased DA turnover. BPR and THP alone reduced striatal ACh level from control, but did not affect any other neurochemical parameters studied. THP and BPR each reversed the effects of soman on DOPAC and HVA levels, but neither affected ChE activity nor ACh level induced by soman. Thus, our findings suggest that the anticonvulsant effects of BPR and THP in soman poisoning may be attributed to their earlier reported muscarinic receptor blocking properties. RP SHIH, TM (reprint author), USA,MED CHEM DEF RES INST,DIV PHARMACOL,ABERDEEN PROVING GROUND,MD 21010, USA. NR 75 TC 11 Z9 11 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0091-3057 J9 PHARMACOL BIOCHEM BE JI Pharmacol. Biochem. Behav. PD MAR PY 1993 VL 44 IS 3 BP 615 EP 622 PG 8 WC Behavioral Sciences; Neurosciences; Pharmacology & Pharmacy SC Behavioral Sciences; Neurosciences & Neurology; Pharmacology & Pharmacy GA KR340 UT WOS:A1993KR34000019 PM 8095723 ER PT J AU SCALORA, M SINGH, S BOWDEN, CM AF SCALORA, M SINGH, S BOWDEN, CM TI ANTI-STOKES GENERATION AND SOLITON DECAY IN STIMULATED RAMAN-SCATTERING SO PHYSICAL REVIEW LETTERS LA English DT Article ID TRANSIENT AB Using numerical methods we find that anti-Stokes generation in stimulated Raman scattering can cause Raman solitons to decay, unless the fields are phase matched. Photon number conservation then leads to unusually high intensities in regions where both the Stokes and anti-Stokes fields vanish. For large propagation lengths, the pump soliton can decay considerably, and as a result, the fields do not interact strongly. We therefore predict the formation of solitonlike pulses at the anti-Stokes frequency. RP SCALORA, M (reprint author), USA,MISSILE COMMAND,CTR RES DEV & ENGN,WEAPONS SCI DIRECTORATE,AMSMI,RD,WS,ST,REDSTONE ARSENAL,AL 35898, USA. NR 19 TC 15 Z9 15 U1 0 U2 0 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0031-9007 J9 PHYS REV LETT JI Phys. Rev. Lett. PD MAR 1 PY 1993 VL 70 IS 9 BP 1248 EP 1250 DI 10.1103/PhysRevLett.70.1248 PG 3 WC Physics, Multidisciplinary SC Physics GA KN887 UT WOS:A1993KN88700016 ER PT J AU CROSS, GM HENNESSEY, PTG AF CROSS, GM HENNESSEY, PTG TI PRINCIPLES AND PRACTICE OF DETOXIFICATION SO PRIMARY CARE LA English DT Article RP CROSS, GM (reprint author), USA,OFF SURGEON GEN,5109 LEESBURG PIKE,ROOM 665,FALLS CHURCH,VA 22041, USA. NR 0 TC 6 Z9 7 U1 0 U2 1 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0095-4543 J9 PRIMARY CARE JI Primary Care PD MAR PY 1993 VL 20 IS 1 BP 81 EP 93 PG 13 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA LA267 UT WOS:A1993LA26700007 PM 8464950 ER PT J AU DEGRASSI, A HILBERT, DM RUDIKOFF, S ANDERSON, AO POTTER, M COON, HG AF DEGRASSI, A HILBERT, DM RUDIKOFF, S ANDERSON, AO POTTER, M COON, HG TI INVITRO CULTURE OF PRIMARY PLASMACYTOMAS REQUIRES STROMAL CELL FEEDER LAYERS SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE ADHESION; NEOPLASIA; PLASMA CELLS ID HUMAN MULTIPLE-MYELOMA; MONOCLONAL ANTIBODY; TISSUE-CULTURE; GROWTH; ESTABLISHMENT; LINES; INTERLEUKIN-6; MACROPHAGE; MOUSE; PROLIFERATION AB Attempts to grow primary murine plasmacytomas in vitro have, to date, been largely unsuccessful. In this study, we demonstrate that long-term in vitro growth of primary plasmacytomas is accomplished by using feeder layers composed of stromal cells from the initial site of plasmacytomagenesis. The early neoplastic lines established in this manner are dependent on physical contact with the stromal layer, which is mediated in part by CD44, for growth and survival. The stromal cells provide at least two stimuli for the plasma cells, one being interleukin 6 and the second, of unknown nature, resulting from direct physical interaction that cannot be replaced by soluble factors. These plasma cell lines have been passaged for as long as 20 months yet still maintain characteristics associated with primary plasmacytomas as they will grow in vivo only in pristane-primed animals, indicating a continued dependence on the pristane-induced microenvironment characteristic of early-stage tumors. The ability to grow primary plasmacytomas in culture and maintain their ''primary'' properties provides a model system for detailed analysis of early events in plasma cell tumor progression involving neoplastic cells completely dependent on physical contact with a stromal feeder layer for survival and expansion. C1 NCI,GENET LAB,BLDG 37,ROOM 2B15,BETHESDA,MD 20892. USA,MED RES INST INFECT DIS,FREDERICK,MD 21701. NR 32 TC 60 Z9 61 U1 0 U2 0 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD MAR 1 PY 1993 VL 90 IS 5 BP 2060 EP 2064 DI 10.1073/pnas.90.5.2060 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA KP979 UT WOS:A1993KP97900089 PM 8446628 ER PT J AU CYGLER, M SCHRAG, JD SUSSMAN, JL HAREL, M SILMAN, I GENTRY, MK DOCTOR, BP AF CYGLER, M SCHRAG, JD SUSSMAN, JL HAREL, M SILMAN, I GENTRY, MK DOCTOR, BP TI RELATIONSHIP BETWEEN SEQUENCE CONSERVATION AND 3-DIMENSIONAL STRUCTURE IN A LARGE FAMILY OF ESTERASES, LIPASES, AND RELATED PROTEINS SO PROTEIN SCIENCE LA English DT Article DE ACETYLCHOLINESTERASE; CONSERVED RESIDUES; ESTERASES; LIPASES; SEQUENCE ALIGNMENT; 3-DIMENSIONAL STRUCTURE ID PANCREATIC CHOLESTEROL ESTERASE; GEOTRICHUM-CANDIDUM LIPASE; AMINO-ACID-SEQUENCE; RAT-LIVER CARBOXYLESTERASE; SITE-SPECIFIC MUTAGENESIS; MOLECULAR-CLONING; CDNA CLONING; DROSOPHILA-MELANOGASTER; SERINE PROTEASES; MULTIGENE FAMILY AB Based on the recently determined X-ray structures of Torpedo californica acetylcholinesterase and Geotrichum candidum lipase and on their three-dimensional superposition, an improved alignment of a collection of 32 related amino acid sequences of other esterases, lipases, and related proteins was obtained. On the basis of this alignment, 24 residues are found to be invariant in 29 sequences of hydrolytic enzymes, and an additional 49 are well conserved. The conservation in the three remaining sequences is somewhat lower. The conserved residues include the active site, disulfide bridges, salt bridges, and residues in the core of the proteins. Most invariant residues are located at the edges of secondary structural elements. A clear structural basis for the preservation of many of these residues can be determined from comparison of the two X-ray structures. C1 WEIZMANN INST SCI, DEPT STRUCT BIOL, IL-76100 REHOVOT, ISRAEL. WEIZMANN INST SCI, DEPT NEUROBIOL, IL-76100 REHOVOT, ISRAEL. WALTER REED ARMY INST RES, DIV BIOCHEM, WASHINGTON, DC 20307 USA. RP CYGLER, M (reprint author), NATL RES COUNCIL CANADA, BIOTECHNOL RES INST, MONTREAL H4P 2R2, PQ, CANADA. OI Sussman, Joel/0000-0003-0306-3878 NR 72 TC 466 Z9 478 U1 1 U2 15 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0961-8368 EI 1469-896X J9 PROTEIN SCI JI Protein Sci. PD MAR PY 1993 VL 2 IS 3 BP 366 EP 382 PG 17 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA KP464 UT WOS:A1993KP46400009 PM 8453375 ER PT J AU WILLINGHAM, WF AF WILLINGHAM, WF TI OREGON-TRAIL SYMPOSIUM 1989, PT 2, HISTORY AND INTERPRETATION - WOODWARD,J SO PUBLIC HISTORIAN LA English DT Book Review RP WILLINGHAM, WF (reprint author), USA CORPS ENGINEERS,PORTLAND,OR, USA. NR 1 TC 1 Z9 1 U1 0 U2 0 PU UNIV CALIF PRESS PI BERKELEY PA JOURNALS DEPT 2120 BERKELEY WAY, BERKELEY, CA 94720 SN 0272-3433 J9 PUBL HISTORIAN JI Public Hist. PD SPR PY 1993 VL 15 IS 2 BP 91 EP 92 PG 2 WC History SC History GA KY640 UT WOS:A1993KY64000011 ER PT J AU WILLINGHAM, WF AF WILLINGHAM, WF TI CULTURAL RESOURCES AND THE OREGON-TRAIL, PT 1, HISTORICAL ARCHAEOLOGY - WOODWARD,J SO PUBLIC HISTORIAN LA English DT Book Review RP WILLINGHAM, WF (reprint author), USA CORPS ENGINEERS,PORTLAND,OR, USA. NR 1 TC 1 Z9 1 U1 0 U2 0 PU UNIV CALIF PRESS PI BERKELEY PA JOURNALS DEPT 2120 BERKELEY WAY, BERKELEY, CA 94720 SN 0272-3433 J9 PUBL HISTORIAN JI Public Hist. PD SPR PY 1993 VL 15 IS 2 BP 91 EP 92 PG 2 WC History SC History GA KY640 UT WOS:A1993KY64000010 ER PT J AU SPECTOR, DE AF SPECTOR, DE TI POWDER AND PROPELLANTS - ENERGETIC MATERIALS AT INDIAN-HEAD, MARYLAND, 1890-1990 - CARLISLE,R SO PUBLIC HISTORIAN LA English DT Book Review RP SPECTOR, DE (reprint author), USA,FT MCCLELLEN,AL, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU UNIV CALIF PRESS PI BERKELEY PA JOURNALS DEPT 2120 BERKELEY WAY, BERKELEY, CA 94720 SN 0272-3433 J9 PUBL HISTORIAN JI Public Hist. PD SPR PY 1993 VL 15 IS 2 BP 144 EP 146 PG 3 WC History SC History GA KY640 UT WOS:A1993KY64000025 ER PT J AU STOKES, CE AF STOKES, CE TI KING OF BATTLE - A BRANCH HISTORY OF THE UNITED-STATES-ARMY FIELD ARTILLERY - DASTRUP,BL SO PUBLIC HISTORIAN LA English DT Book Review RP STOKES, CE (reprint author), USA,FT GORDON,GA 30905, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU UNIV CALIF PRESS PI BERKELEY PA JOURNALS DEPT 2120 BERKELEY WAY, BERKELEY, CA 94720 SN 0272-3433 J9 PUBL HISTORIAN JI Public Hist. PD SPR PY 1993 VL 15 IS 2 BP 154 EP 155 PG 2 WC History SC History GA KY640 UT WOS:A1993KY64000029 ER PT J AU FOLKES, PA AF FOLKES, PA TI VOLTAGE DEPENDENCE OF TRAP-GENERATED 1/F NOISE IN MESFETS SO SOLID-STATE ELECTRONICS LA English DT Note ID FIELD-EFFECT TRANSISTORS; OCCUPANCY MODEL RP FOLKES, PA (reprint author), USA,RES LAB,FT MONMOUTH,NJ 07703, USA. NR 6 TC 1 Z9 1 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0038-1101 J9 SOLID STATE ELECTRON JI Solid-State Electron. PD MAR PY 1993 VL 36 IS 3 BP 483 EP 484 DI 10.1016/0038-1101(93)90105-Y PG 2 WC Engineering, Electrical & Electronic; Physics, Applied; Physics, Condensed Matter SC Engineering; Physics GA KP193 UT WOS:A1993KP19300024 ER PT J AU DOYLE, M JOHNSTONE, PAS WATKINS, EB AF DOYLE, M JOHNSTONE, PAS WATKINS, EB TI ROLE OF RADIATION-THERAPY IN MANAGEMENT OF PULMONARY KAPOSIS-SARCOMA SO SOUTHERN MEDICAL JOURNAL LA English DT Article ID ACQUIRED IMMUNODEFICIENCY SYNDROME; VINBLASTINE; AIDS; CHEMOTHERAPY; VINCRISTINE; COMBINATION AB Although the incidence of AIDS-related Kaposi's sarcoma (KS) has been declining in recent years, the uncommon and unfortunate progression to symptomatic pulmonary KS still represents a significant therapeutic challenge. Pulmonary KS generally occurs in the late stages of the disease. Review of the literature and of the experience of the Walter Reed Army Medical Center Radiation Oncology Service suggests that early intervention with radiation therapy may provide palliation of the often distressing symptoms that herald KS-induced respiratory failure and may have a favorable impact on quality of life and survival time. C1 UNIFORMED SERV UNIV HLTH SCI, BETHESDA, MD 20814 USA. NCI, RADIAT ONCOL BRANCH, BETHESDA, MD 20892 USA. RP WALTER REED ARMY MED CTR, DEPT PSYCHIAT, RADIAT THERAPY SERV, WASHINGTON, DC 20307 USA. NR 19 TC 10 Z9 10 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0038-4348 EI 1541-8243 J9 SOUTH MED J JI South.Med.J. PD MAR PY 1993 VL 86 IS 3 BP 285 EP 288 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA KT726 UT WOS:A1993KT72600005 PM 7680826 ER PT J AU MORRIS, JT MCALLISTER, CK AF MORRIS, JT MCALLISTER, CK TI FUNGEMIA DUE TO TORULOPSIS-GLABRATA SO SOUTHERN MEDICAL JOURNAL LA English DT Note ID PATIENT RP MORRIS, JT (reprint author), BROOKE ARMY MED CTR,INFECT DIS SERV,FT SAM HOUSTON,TX 78234, USA. NR 9 TC 6 Z9 6 U1 0 U2 0 PU SOUTHERN MEDICAL ASSN PI BIRMINGHAM PA 35 LAKESHORE DR PO BOX 190088, BIRMINGHAM, AL 35219 SN 0038-4348 J9 SOUTHERN MED J JI South.Med.J. PD MAR PY 1993 VL 86 IS 3 BP 356 EP 357 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA KT726 UT WOS:A1993KT72600020 PM 8451678 ER PT J AU SOLOMON, BL WARTOFSKY, L BURMAN, KD AF SOLOMON, BL WARTOFSKY, L BURMAN, KD TI PREVALENCE OF FRACTURES IN POSTMENOPAUSAL WOMEN WITH THYROID-DISEASE SO THYROID LA English DT Article ID BONE-MINERAL DENSITY; L-THYROXINE THERAPY; PREMENOPAUSAL WOMEN; HYPERTHYROIDISM; HIP; THYROTOXICOSIS; OSTEOPOROSIS AB We interviewed 300 white postmenopausal women (160 with thyroid disease, 140 without thyroid disease) to investigate whether having thyroid disease or taking thyroid hormone increased the prevalence of having a hip, vertebral, or forearm fracture. Thirty-seven (23%) women with thyroid disease and 45 (32%) women without thyroid disease had had a fracture, and there were no significant differences between these groups in the number or type of fractures. Dose of thyroid hormone and duration of therapy or disease did not affect fracture occurrence in women with thyroid disease. Women with a history of hyperthyroidism (9 of 32) or thyroid cancer (2 of 11) appeared to have their first fracture earlier (p < 0.01) than women without thyroid disease. In summary, women taking thyroid hormone for a variety of thyroid disorders do not appear to have an enhanced prevalence of a hip, vertebral, or forearm fractures, but women with a history of hyperthyroidism may have a propensity for their fractures to occur earlier in life. C1 WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. RP SOLOMON, BL (reprint author), WALTER REED ARMY MED CTR,DEPT MED,ENDOCRINOL METAB SERV 7D,WASHINGTON,DC 20307, USA. NR 23 TC 99 Z9 101 U1 1 U2 1 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 1050-7256 J9 THYROID JI Thyroid PD SPR PY 1993 VL 3 IS 1 BP 17 EP 23 DI 10.1089/thy.1993.3.17 PG 7 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA KZ824 UT WOS:A1993KZ82400003 PM 8499760 ER PT J AU BAKER, B TU, AT MIDDLEBROOK, JL AF BAKER, B TU, AT MIDDLEBROOK, JL TI BINDING OF MYOTOXIN-A TO CULTURED MUSCLE-CELLS SO TOXICON LA English DT Article ID CROTALUS-VIRIDIS-VIRIDIS; AMERICAN RATTLESNAKE VENOM; SARCOPLASMIC-RETICULUM; DIPHTHERIA-TOXIN; SKELETAL-MUSCLE; CONCOLOR VENOM; CROTAMINE; SEQUENCES; RECEPTOR AB The binding of radiolabeled myotoxin a to various cultured cell lines was evaluated. One rat skeletal muscle-derived cell line, L8, bound substantially more myotoxin a than did all other cell lines examined. Several biophysical parameters of myotoxin a-L8 binding were determined. Binding was saturable with a moderate binding affinity. Scatchard analysis and Hill plots indicated a single class of binding sites. The binding was reversible, as demonstrated by chase experiments. Radiolabeled myotoxin a bound to the cell surface at a site inaccessible to the general protease, pronase. Specificity and biological relevance of the binding was suggested by competition with unlabeled toxin and various peptides derived from the toxin. Biologically active peptides, corresponding to the N- and C-terminal sequence of myotoxin a, competed with radiolabeled toxin for L8 binding. It was concluded that the L8 system is a suitable cell model to study myotoxin a mechanism of action. C1 USA,MED RES INST INFECT DIS,DIV TOXINOL,FREDERICK,MD 21702. COLORADO STATE UNIV,DEPT BIOCHEM,FT COLLINS,CO 80523. FU NIGMS NIH HHS [5R37GM15591] NR 31 TC 11 Z9 11 U1 0 U2 3 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0041-0101 J9 TOXICON JI Toxicon PD MAR PY 1993 VL 31 IS 3 BP 271 EP 284 DI 10.1016/0041-0101(93)90145-9 PG 14 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA KQ779 UT WOS:A1993KQ77900006 PM 8470132 ER PT J AU SHAVER, TR SWANSON, SJ FERNANDEZBUENO, C KOCANDRLE, V AF SHAVER, TR SWANSON, SJ FERNANDEZBUENO, C KOCANDRLE, V TI THE OPTIMAL TREATMENT OF LYMPHOCELES FOLLOWING RENAL-TRANSPLANTATION SO TRANSPLANT INTERNATIONAL LA English DT Article DE LYMPHOCELES; LAPAROSCOPIC TREATMENT, LYMPHOCELE; KIDNEY TRANSPLANTATION, LYMPHOCELE AB Lymphoceles are well-recognized complications following kidney transplantation. The authors describe their experience with the treatment of eight clinically significant lymphoceles (incidence 2.7 %). In seven patients percutaneous needle aspiration was attempted, often repeatedly, both for diagnostic and therapeutic purposes. In all of the patients the lymphocele recurred within days and internal marsupialization was therefore performed, in the last two patients utilizing minimal access surgery through laparoscopy. There were no postoperative complications or signs of a recurrence of the lymphocele. Patients following the laparoscopic marsupialization had a much briefer hospital stay and postoperative convalescence. Our results confirm that internal marsupialization is the procedure of choice for most post-transplant lymphoceles. Internal marsupialization through laparoscopy should be used in patients who meet the standard criteria for laparoscopy. RP SHAVER, TR (reprint author), WALTER REED ARMY MED CTR,ORGAN TRANSPLANT SERV,WASHINGTON,DC 20307, USA. NR 0 TC 26 Z9 27 U1 0 U2 0 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0934-0874 J9 TRANSPLANT INT JI Transpl. Int. PD MAR PY 1993 VL 6 IS 2 BP 108 EP 110 DI 10.1111/j.1432-2277.1993.tb00760.x PG 3 WC Surgery; Transplantation SC Surgery; Transplantation GA KL756 UT WOS:A1993KL75600009 PM 8447923 ER PT J AU TRAMONT, EC BURKE, DS AF TRAMONT, EC BURKE, DS TI AIDS HIV IN THE UNITED-STATES MILITARY SO VACCINE LA English DT Article DE HIV; UNITED-STATES MILITARY; SURVEILLANCE; EDUCATION; FIELD TEST; VACCINE AB HIV infection (AIDS) burst upon the scene a decade ago. Because it is a sexually transmitted disease that infects blood and kills its victim, it is military relevant and will impact on all aspects of the military. The US Army Medical Research and Development Command as 'Lead Agent for Infectious Disease Research' in the Department of Defense has developed a comprehensive approach to address military concerns: surveillance of infection rates (intelligence) around the world and in the military; behavioural research to develop more effective means of education to change behaviour; and biological research to develop a quick and easy field test, and a vaccine or drug to prevent the disease from occurring despite exposure. Its success will influence the success of the Army in the future. C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,WASHINGTON,DC 20307. NR 4 TC 3 Z9 4 U1 0 U2 0 PU BUTTERWORTH-HEINEMANN LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB SN 0264-410X J9 VACCINE JI Vaccine PD MAR PY 1993 VL 11 IS 5 BP 529 EP 533 DI 10.1016/0264-410X(93)90224-L PG 5 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA KX418 UT WOS:A1993KX41800010 PM 8488704 ER PT J AU MAPOU, RL RUNDELL, JR KAY, GG TRAMONT, EC AF MAPOU, RL RUNDELL, JR KAY, GG TRAMONT, EC TI RELATING COGNITIVE FUNCTION TO MILITARY AVIATOR PERFORMANCE IN EARLY HIV-INFECTION SO VACCINE LA English DT Article DE HIV; COGNITIVE FUNCTION; MEASUREMENT ID IMMUNODEFICIENCY-VIRUS INFECTION; MULTICENTER AIDS COHORT; HOMOSEXUAL MEN; INDIVIDUALS AB There has been controversy about whether cognitive changes occur in early human immunodeficiency virus (HIV) disease. In those studies reporting cognitive changes, these are typically subclinical, and their relationship to daily and/or occupational functioning has not been addressed. The potential effects of changes may vary as a function of occupational demands. This is germane to military performance, where occupational demands cover a wide spectrum of complexity. In particular, such effects are important to consider in the many cognitively demanding specialties associated with military aviation. This paper will explore ways in which possible HIV-related military performance decrements in aviators may be measured empirically. First, studies from Walter Reed Army Medical Center (WRAMC), which have shown cognitive changes in early HIV disease, will be described. This will be followed by a summary of presentations and discussions at a conference in November 1990, entitled 'HIV and Military Performance: Assessment Methodologies' held at WRAMC. The third section of the paper will describe a programme of research, which is developing measures to detect cognitive difficulties in civilian aviators. The application of measures from this research to research on HIV will be discussed. Finally, a research programme being developed to examine the possible impact of HIV-related cognitive changes on military aviator performance will be described. C1 UNIFORMED SERV UNIV HLTH SCI,DEPT PSYCHIAT,BETHESDA,MD 20814. WALTER REED ARMY INST RES,WASHINGTON,DC 20307. GEORGETOWN UNIV,SCH MED,DEPT NEUROL,WASHINGTON,DC 20057. RP MAPOU, RL (reprint author), HENRY M JACKSON FDN ADVANCEMENT MIL MED,1 TAFT COURT,SUITE 250,ROCKVILLE,MD 20850, USA. NR 25 TC 3 Z9 3 U1 0 U2 0 PU BUTTERWORTH-HEINEMANN LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB SN 0264-410X J9 VACCINE JI Vaccine PD MAR PY 1993 VL 11 IS 5 BP 555 EP 559 DI 10.1016/0264-410X(93)90231-L PG 5 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA KX418 UT WOS:A1993KX41800017 PM 8488710 ER PT J AU GORDON, DM AF GORDON, DM TI USE OF NOVEL ADJUVANTS AND DELIVERY SYSTEMS TO IMPROVE THE HUMORAL AND CELLULAR IMMUNE-RESPONSE TO MALARIA VACCINE CANDIDATE ANTIGENS SO VACCINE LA English DT Article DE MALARIA VACCINES; ADJUVANTS; DELIVERY SYSTEM ID LIPID-A; LIPOSOMES AB The immune effector mechanisms responsible for the solid protection against malaria, as demonstrated by immunization with radiation-attenuated sporozoites, are poorly understood. An effective malaria vaccine must induce a well orchestrated combination of humoral and cellular immune responses directed against critical parasite antigens/epitopes expressed during different stages of the parasite's complicated life cycle. Currently licensed human vaccine adjuvants, such as alum, may improve antibody production but are poor stimulators of cellular effector mechanisms, while potent cellular stimulants such as Freund's adjuvant are too reactogenic for human use. Over the last 5 years we have systematically evaluated several methods of antigen presentation to include chemical conjugation to bacterial carrier proteins, emulsification in 'Freund's-like' preparations, and incorporation into liposomes. This work has resulted in the production of safe, potent vaccine delivery systems capable of targeting multiple antigenic determinants to the host's immune system. Further advances in malaria vaccine development now depend on the identification of appropriate parasite epitopes for inclusion in a multicomponent-multistage vaccine. RP GORDON, DM (reprint author), WALTER REED ARMY INST RES,DEPT IMMUNOL,WASHINGTON,DC 20307, USA. NR 15 TC 20 Z9 20 U1 0 U2 1 PU BUTTERWORTH-HEINEMANN LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB SN 0264-410X J9 VACCINE JI Vaccine PD MAR PY 1993 VL 11 IS 5 BP 591 EP 593 DI 10.1016/0264-410X(93)90239-T PG 3 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA KX418 UT WOS:A1993KX41800025 PM 8488718 ER PT J AU WILLIAMS, BH EIGHMY, JJ BERBERT, MH DUNN, DG AF WILLIAMS, BH EIGHMY, JJ BERBERT, MH DUNN, DG TI CERVICAL CHORDOMA IN 2 FERRETS (MUSTELA-PUTORIUS-FURO) SO VETERINARY PATHOLOGY LA English DT Note DE CHORDOMA; FERRETS; METASTASIS ID NERVOUS-SYSTEM; TUMORS; RATS RP WILLIAMS, BH (reprint author), USA,INST PATHOL,DEPT VET PATHOL,WASHINGTON,DC 20306, USA. NR 15 TC 19 Z9 20 U1 0 U2 1 PU AMER COLL VET PATHOLOGIST PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 SN 0300-9858 J9 VET PATHOL JI Vet. Pathol. PD MAR PY 1993 VL 30 IS 2 BP 204 EP 206 PG 3 WC Pathology; Veterinary Sciences SC Pathology; Veterinary Sciences GA KV429 UT WOS:A1993KV42900014 PM 7682370 ER PT J AU DUNN, DG GARDINER, CH DRALLE, KR THILSTED, JP AF DUNN, DG GARDINER, CH DRALLE, KR THILSTED, JP TI NODULAR GRANULOMATOUS POSTHITIS CAUSED BY HALICEPHALOBUS (SYN MICRONEMA) SP IN A HORSE SO VETERINARY PATHOLOGY LA English DT Note DE HALICEPHALOBUS; HORSES; MICRONEMA; POSTHITIS ID INFECTION RP DUNN, DG (reprint author), USA,INST PATHOL,DIV EDITORIAL,WASHINGTON,DC 20306, USA. NR 10 TC 34 Z9 35 U1 0 U2 2 PU AMER COLL VET PATHOLOGIST PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 SN 0300-9858 J9 VET PATHOL JI Vet. Pathol. PD MAR PY 1993 VL 30 IS 2 BP 207 EP 208 PG 2 WC Pathology; Veterinary Sciences SC Pathology; Veterinary Sciences GA KV429 UT WOS:A1993KV42900015 PM 8470341 ER PT J AU RUUD, CO JOSEF, JA SNOHA, DJ AF RUUD, CO JOSEF, JA SNOHA, DJ TI RESIDUAL-STRESS CHARACTERIZATION OF THICK-PLATE WELDMENTS USING X-RAY-DIFFRACTION SO WELDING JOURNAL LA English DT Article DE RESIDUAL STRESS; THICK PLATE; X-RAY DIFFRACTION; MULTIPASS WELDMENT; WELD-INDUCED STRESS; STRESS PATTERNS; ROLLED PLATE; SURFACE STRESS; YIELD STRENGTH ID INSTRUMENTATION AB The objective of this investigation was to measure the residual stress field in a thick multipass weldment using x-ray diffraction (XRD) techniques. The sample under study was a 13-in. (33-cm) thick, multipass, V-groove butt joint weldment of 2 1/4-Cr 1-Mo steel plate. Nearly 10,000 stress measurements were performed on the weldment, producing over 72 plots of stress traverses, to provide the most thorough experimental analysis of a weldment to date. The data indicate the complexity of the stress field in thick multipass weldments and the magnitude of the difficulties to be faced in developing numerical models for residual stresses in these weldments. This paper is restricted to reporting and discussing the welding-induced stress patterns on the rolled plate surface. It is these surfaces that are normally exposed for crack initiation. C1 LOS ALAMOS NATL LAB,DIV NUCL ENGN & TECHNOL,LOS ALAMOS,NM 87544. USA,MAT TECHNOL LAB,WATERTOWN,MA 02172. RP RUUD, CO (reprint author), PENN STATE UNIV,DEPT IND & MANAGEMENT SYST ENGN,UNIV PK,PA 16802, USA. NR 9 TC 3 Z9 3 U1 0 U2 1 PU AMER WELDING SOC PI MIAMI PA PO BOX 351040, MIAMI, FL 33135 SN 0043-2296 J9 WELD J JI Weld. J. PD MAR PY 1993 VL 72 IS 3 BP S87 EP S91 PG 5 WC Metallurgy & Metallurgical Engineering SC Metallurgy & Metallurgical Engineering GA KP840 UT WOS:A1993KP84000013 ER PT J AU ZIRL, DM VLADIMIROFF, T AF ZIRL, DM VLADIMIROFF, T TI AN ABINITIO STUDY OF SOME NITRAMINE MOLECULES SO THEOCHEM-JOURNAL OF MOLECULAR STRUCTURE LA English DT Article ID DIFFRACTION AB Ab initio self-consistent field (SCF) molecular orbital calculations have been performed for a series of nitramine molecules. Calculations were conducted on trinitramine, methyldinitramine, methylchloronitramine and trimethylamine using Pople's 6-31G and 6-31G* basis sets. Gas phase geometries for these molecules were determined by a minimum energy criterion using gradient techniques. The results are in qualitative agreement with the geometries derived from electron diffraction studies and microwave spectroscopy. The extra-long N-N bonds in methyldinitramine and methylchloronitramine were not computed accurately at the SCF level of theory and it was shown that these bonds become longer if electron correlation is included at the second-order Moller-Plesset level. Computations were performed for the heat of formation for trinitramine using Pople's isodesmic reaction concept and compared with a value obtained using an additivity rule. C1 USA,CTR RES DEV & ENGN,PICATINNY ARSENAL,NJ 07806. NR 24 TC 0 Z9 0 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-1280 J9 THEOCHEM-J MOL STRUC JI Theochem-J. Mol. Struct. PD FEB 25 PY 1993 VL 98 BP 291 EP 297 PG 7 WC Chemistry, Physical SC Chemistry GA KR859 UT WOS:A1993KR85900033 ER PT J AU ASKEW, EW MOORE, RJ FRIEDL, KE HOYT, RW AF ASKEW, EW MOORE, RJ FRIEDL, KE HOYT, RW TI NUTRITIONAL-STATUS AND BODY-COMPOSITION CHANGES DURING SUSTAINED PHYSICAL WORK AND CALORIE DEPRIVATION SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 23 PY 1993 VL 7 IS 4 BP A613 EP A613 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA KP975 UT WOS:A1993KP97500543 ER PT J AU BOWERSOX, SL BYERS, CE ANDERSON, DR HARRIS, LW AF BOWERSOX, SL BYERS, CE ANDERSON, DR HARRIS, LW TI INTERACTION OF MMB-4 WITH C(+)P(+) SOMAN ISOMER AND INHIBITION OF ACETYLCHOLINESTERASE INVITRO SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,MRICD,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 1 Z9 1 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 23 PY 1993 VL 7 IS 4 BP A699 EP A699 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA KP975 UT WOS:A1993KP97501034 ER PT J AU BYERS, CE CAPACIO, BR ANDERSON, DR MATTHEWS, RL AF BYERS, CE CAPACIO, BR ANDERSON, DR MATTHEWS, RL TI EFFECTS OF THE 5HT(3) ANTAGONIST ONDANSETRON ON THE ACHE INHIBITION BY PYRIDOSTIGMINE SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 23 PY 1993 VL 7 IS 4 BP A699 EP A699 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA KP975 UT WOS:A1993KP97501037 ER PT J AU CAPACIO, BR BYERS, CE MATTHEWS, RL AF CAPACIO, BR BYERS, CE MATTHEWS, RL TI EFFECT OF PYRIDOSTIGMINE ON PHARMACOKINETICS OF THE 5-HT(3) RECEPTOR ANTAGONIST ONDANSETRON SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 3 Z9 3 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 23 PY 1993 VL 7 IS 4 BP A699 EP A699 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA KP975 UT WOS:A1993KP97501035 ER PT J AU CHUANG, AH FARNSWORTH, WJ MCPHERSON, JC MCPHERSON, JC AF CHUANG, AH FARNSWORTH, WJ MCPHERSON, JC MCPHERSON, JC TI TEMPERATURE-DEPENDENT FLUORIDE INDUCED HEMOLYSIS IS ANTAGONIZED BY POLOXAMER-188 SO FASEB JOURNAL LA English DT Meeting Abstract C1 MED COLL GEORGIA,AUGUSTA,GA 30912. EISENHOWER ARMY MED CTR,FT GORDON,GA 30905. NR 1 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 23 PY 1993 VL 7 IS 4 BP A681 EP A681 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA KP975 UT WOS:A1993KP97500935 ER PT J AU FARNSWORTH, WJ CHUANG, AH RUNNER, RR MCPHERSON, JC MCPHERSON, JC AF FARNSWORTH, WJ CHUANG, AH RUNNER, RR MCPHERSON, JC MCPHERSON, JC TI THE GLASS EFFECT ON RED-BLOOD-CELLS CAN BE PREVENTED BY PLURONIC F-68(R) SO FASEB JOURNAL LA English DT Meeting Abstract C1 EISENHOWER ARMY MED CTR,FT GORDON,GA. MED COLL GEORGIA,AUGUSTA,GA 30912. NR 0 TC 1 Z9 1 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 23 PY 1993 VL 7 IS 4 BP A682 EP A682 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA KP975 UT WOS:A1993KP97500942 ER PT J AU HORNER, JA PAUSTIAN, PW CHUANG, AH RUNNER, RR MCPHERSON, JC MCPHERSON, JC AF HORNER, JA PAUSTIAN, PW CHUANG, AH RUNNER, RR MCPHERSON, JC MCPHERSON, JC TI POLOXAMER-407 INCREASES ROULEAU FORMATION INVIVO BUT NOT INVITRO SO FASEB JOURNAL LA English DT Meeting Abstract C1 EISENHOWER ARMY MED CTR,FT GORDON,GA 30905. MED COLL GEORGIA,AUGUSTA,GA 30912. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 23 PY 1993 VL 7 IS 4 BP A681 EP A681 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA KP975 UT WOS:A1993KP97500937 ER PT J AU HOYT, RW MOORE, RJ DELANY, JP FRIEDL, KE ASKEW, EW AF HOYT, RW MOORE, RJ DELANY, JP FRIEDL, KE ASKEW, EW TI ENERGY-BALANCE DURING 62 DAYS OF RIGOROUS PHYSICAL-ACTIVITY AND CALORIC RESTRICTION SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. PENNINGTON BIOMED RES CTR,BATON ROUGE,LA 70808. NR 0 TC 5 Z9 5 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 23 PY 1993 VL 7 IS 4 BP A726 EP A726 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA KP975 UT WOS:A1993KP97501187 ER PT J AU JONES, TE HOYT, RW DELANY, JP HESSLINK, RL ASKEW, EW AF JONES, TE HOYT, RW DELANY, JP HESSLINK, RL ASKEW, EW TI A COMPARISON OF 2 METHODS OF MEASURING WATER-INTAKE OF SOLDIERS IN THE FIELD SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. PENNIGTON BIOMED RES CTR,BATON ROUGE,LA 70808. USN,HLTH RES CTR,SAN DIEGO,CA 92186. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 23 PY 1993 VL 7 IS 4 BP A610 EP A610 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA KP975 UT WOS:A1993KP97500528 ER PT J AU LECLAIRE, RD COBLENTZ, FE PARKER, GW AF LECLAIRE, RD COBLENTZ, FE PARKER, GW TI STAPHYLOCOCCAL ENTEROTOXIN-B-ELICITED NITROGEN-OXIDE PRODUCTION IN MURINE ENDOTHELIAL-CELLS SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,MED RES INST INFECT DIS,FT DETRICK,MD 21702. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 23 PY 1993 VL 7 IS 4 BP A561 EP A561 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA KP975 UT WOS:A1993KP97500248 ER PT J AU OYEJIDE, A TSENG, J KOMISAR, J HUNT, R AF OYEJIDE, A TSENG, J KOMISAR, J HUNT, R TI IMMUNOHISTOCHEMICAL ANALYSIS OF PULMONARY INFLAMMATORY CELLS AND MEDIATORS IN RHESUS-MONKEYS CHALLENGED WITH AEROSOLIZED STAPHYLOCOCCAL ENTEROTOXIN-B SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 23 PY 1993 VL 7 IS 4 BP A640 EP A640 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA KP975 UT WOS:A1993KP97500701 ER PT J AU RAY, P BERMAN, JD MIDDLETON, W BRENDLE, J AF RAY, P BERMAN, JD MIDDLETON, W BRENDLE, J TI ARACHIDONIC-ACID IS INVOLVED IN STIMULUS INDUCED ACETYLCHOLINE-RELEASE AND ITS INHIBITION BY BOTULINUM TOXIN SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 23 PY 1993 VL 7 IS 4 BP A699 EP A699 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA KP975 UT WOS:A1993KP97501033 ER PT J AU RUBAL, BJ BAILEY, SR AF RUBAL, BJ BAILEY, SR TI ALTERED VASCULAR TAPER DURING CHANGES IN BLOOD-PRESSURE SO FASEB JOURNAL LA English DT Meeting Abstract C1 BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234. UNIV TEXAS,HLTH SCI CTR,SAN ANTONIO,TX 78284. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 23 PY 1993 VL 7 IS 4 BP A763 EP A763 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA KP975 UT WOS:A1993KP97501398 ER PT J AU RUNNER, RR STONE, RL MCPHERSON, JC MCPHERSON, JC AF RUNNER, RR STONE, RL MCPHERSON, JC MCPHERSON, JC TI POLOXAMER-188 ADMINISTRATION ALTERS SOME EVENTS IN THE BLOOD-CLOTTING CASCADE SO FASEB JOURNAL LA English DT Meeting Abstract C1 EISENHOWER ARMY MED CTR,FT GORDON,GA. MED COLL GEORGIA,AUGUSTA,GA 30912. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 23 PY 1993 VL 7 IS 4 BP A682 EP A682 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA KP975 UT WOS:A1993KP97500939 ER PT J AU SILS, IV SZLYK, PC TARTARINI, K HUBBARD, L GLASS, E CARETTI, D DARRIGRAND, A AF SILS, IV SZLYK, PC TARTARINI, K HUBBARD, L GLASS, E CARETTI, D DARRIGRAND, A TI CHRONIC IMPLANTATION OF NONOCCLUSIVE CATHETERS AND FLOW PROBES IN THE SPLANCHNIC BED IN THE RABBIT SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. NR 1 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 23 PY 1993 VL 7 IS 4 BP A780 EP A780 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA KP975 UT WOS:A1993KP97501498 ER PT J AU SMITH, NC PLESS, D THOMPSON, WL WELLNER, RB LECLAIRE, RD AF SMITH, NC PLESS, D THOMPSON, WL WELLNER, RB LECLAIRE, RD TI RICIN DEPRESSES INDUCIBLE NITROGEN-OXIDE PRODUCTION IN MURINE ENDOTHELIAL-CELLS SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,MED RES INST INFECT DIS,FREDERICK,MD 21702. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 23 PY 1993 VL 7 IS 4 BP A561 EP A561 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA KP975 UT WOS:A1993KP97500252 ER PT J AU SZLYK, PC SILS, IV TARTARINI, KA FRANCESCONI, RP AF SZLYK, PC SILS, IV TARTARINI, KA FRANCESCONI, RP TI REGIONAL DIFFERENCES IN BLOOD-GASES AND FLOWS IN THE SPLANCHNIC BED IN THE AWAKE RABBIT SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 23 PY 1993 VL 7 IS 4 BP A780 EP A780 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA KP975 UT WOS:A1993KP97501495 ER PT J AU TANG, TL KIANG, JG COX, BM AF TANG, TL KIANG, JG COX, BM TI EXCITATORY EFFECT OF OPIOIDS ON CYTOSOLIC FREE [CA2+] IN NEURONAL CELL-LINE ND8-47 SO FASEB JOURNAL LA English DT Meeting Abstract C1 UNIFORMED SERV UNIV HLTH SCI,DEPT PHARMACOL,BETHESDA,MD 20814. WALTER REED ARMY INST RES,DIV MED,DEPT CLIN PHYSIOL,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 23 PY 1993 VL 7 IS 4 BP A704 EP A704 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA KP975 UT WOS:A1993KP97501062 ER PT J AU TOBIAS, SW STONE, RL RUNNER, RR MCPHERSON, JC MCPHERSON, JC AF TOBIAS, SW STONE, RL RUNNER, RR MCPHERSON, JC MCPHERSON, JC TI THE ERYTHROCYTE SEDIMENTATION-RATE OF BLOOD IN NORMAL RATS INJECTED WITH PLURONIC F-127(R) SO FASEB JOURNAL LA English DT Meeting Abstract C1 MED COLL GEORGIA,AUGUSTA,GA 30912. EISENHOWER ARMY MED CTR,FT GORDON,GA 30905. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 23 PY 1993 VL 7 IS 4 BP A681 EP A681 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA KP975 UT WOS:A1993KP97500938 ER PT J AU MIZIOLEK, AW LONG, SR CROSLEY, DR AF MIZIOLEK, AW LONG, SR CROSLEY, DR TI INTRODUCTION TO THE LACA-III FEATURE ISSUE OF APPLIED OPTICS SO APPLIED OPTICS LA English DT Editorial Material AB This is the introduction to the Applied Optics feature issue on Laser Applications to Chemical Analysis III. The issue is an outgrowth of the Topical Meeting on Laser Applications to Chemical Analysis III that was held in January 1992. C1 USA, EDGEWOOD RES DEV & ENGN CTR, SMCCRRSL, ABERDEEN PROVING GROUND, MD 21010 USA. SRI INT, DEPT ORAL HLTH RES, MENLO PK, CA 94025 USA. RP MIZIOLEK, AW (reprint author), USA, RES LAB, AMSRLWTPC, ABERDEEN PROVING GROUND, MD 21005 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 0003-6935 J9 APPL OPTICS JI Appl. Optics PD FEB 20 PY 1993 VL 32 IS 6 BP 793 EP 793 PG 1 WC Optics SC Optics GA KM929 UT WOS:A1993KM92900001 PM 20802753 ER PT J AU SIMEONSSON, JB MIZIOLEK, AW AF SIMEONSSON, JB MIZIOLEK, AW TI TIME-RESOLVED EMISSION STUDIES OF ARF-LASER-PRODUCED MICROPLASMAS SO APPLIED OPTICS LA English DT Article ID INDUCED BREAKDOWN SPECTROSCOPY; ULTRAVIOLET-LASER; SPECTROMETRY; PLASMA; AIR; DETECTOR; METALS; ATOMS AB ArF-laser-produced microplasmas in CO, CO2, Methanol, and chloroform are studied by time-resolved emission measurements of the plasma decay. Electron densities are deduced from Stark broadening of the line profiles of atomic H, C, O, and Cl. Plasma ionization and excitation temperatures are determined from measurements of relative populations of ionic and neutral species produced in the plasmas. A discussion of the thermodynamic equilibrium status of ArF-laser microplasmas is presented. In general, the ArF-laser-produced microplasma environment is found to be similar in all the gases studied, in terms of both temperature (15,000-20,000 K) and electron density (10(17) cm-3-10(18) cm-3), despite the considerable differences observed in the breakdown thresholds and relative energies deposited in the various gases. RP SIMEONSSON, JB (reprint author), USA, BALLIST RES LAB, SLCBRIBI, ABERDEEN PROVING GROUND, MD 21005 USA. NR 30 TC 73 Z9 73 U1 0 U2 17 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 0003-6935 J9 APPL OPTICS JI Appl. Optics PD FEB 20 PY 1993 VL 32 IS 6 BP 939 EP 947 PG 9 WC Optics SC Optics GA KM929 UT WOS:A1993KM92900019 PM 20802771 ER PT J AU SCHNEIDER, NS ILLINGER, JL KARASZ, FE AF SCHNEIDER, NS ILLINGER, JL KARASZ, FE TI THE INTERACTION OF WATER WITH POLYURETHANES CONTAINING BLOCK COPOLYMER SOFT SEGMENTS SO JOURNAL OF APPLIED POLYMER SCIENCE LA English DT Article ID PHASE AB The saturation water uptake and nonfreezing water, determined as a function of temperature in a polyurethane containing the pure polyethylene oxide soft segment (I) and in polyurethanes containing block copolymer polyethylene oxide/polypropylene oxide soft segments (II), show significantly different behavior. In sample I, the water content and nonfreezing water are only weakly dependent on temperature from 276 to 333 K. In the samples based on II, with various ratios of the hydrophilic and hydrophobic segments, there is a strong decrease in solubility with temperature and a steep drop above 303 K. The nonfreezing water exhibits a parallel trend. This behavior is interpreted in terms of the temperature-dependent phase compatibility of the polyethylene oxide and polypropylene oxide segments of II. C1 USA,MAT TECHNOL LAB,POLYMER RES BRANCH,SLCMT EMP,WATERTOWN,MA 02172. UNIV MASSACHUSETTS,DEPT POLYMER SCI & ENGN,AMHERST,MA 01003. RP SCHNEIDER, NS (reprint author), GEOCENTERS INC,7 WELLS AVE,NEWTON,MA 02159, USA. NR 11 TC 23 Z9 23 U1 0 U2 0 PU JOHN WILEY & SONS INC PI NEW YORK PA 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0021-8995 J9 J APPL POLYM SCI JI J. Appl. Polym. Sci. PD FEB 20 PY 1993 VL 47 IS 8 BP 1419 EP 1425 DI 10.1002/app.1993.070470813 PG 7 WC Polymer Science SC Polymer Science GA KJ600 UT WOS:A1993KJ60000013 ER PT J AU PINNICK, RG FERNANDEZ, G MARTINEZANDAZOLA, E HINDS, BD HANSEN, ADA FULLER, K AF PINNICK, RG FERNANDEZ, G MARTINEZANDAZOLA, E HINDS, BD HANSEN, ADA FULLER, K TI AEROSOL IN THE ARID SOUTHWESTERN UNITED-STATES - MEASUREMENTS OF MASS LOADING, VOLATILITY, SIZE DISTRIBUTION, ABSORPTION CHARACTERISTICS, BLACK CARBON CONTENT, AND VERTICAL STRUCTURE TO 7 KM ABOVE SEA-LEVEL SO JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES LA English DT Article ID CLASSICAL ELECTROMAGNETIC SCATTERING; COMPLEX REFRACTIVE-INDEX; REAL-TIME MEASUREMENT; RESPONSE CHARACTERISTICS; ABSORBING COMPONENT; CONSUMMATE SOLUTION; PARTICULATE CARBON; ELEMENTAL CARBON; LIGHT-ABSORPTION; SOIL PARTICLES AB Near-surface and lower tropospheric aerosol characteristics have been determined at several remote sites near Orogrande, New Mexico, using a variety of methods and sensors including quartz fiber filter samplers, hi-vol samplers, ground-based and aircraft-mounted light-scattering aerosol counters, an aerosol counter equipped with a heated inlet, and an aethalometer (a device that measures aerosol absorption). The results of these measurements, which have been taken sporadically over the last 15 years but with a higher density of measurements during 1989-1991, suggest that regardless of season, aerosol consists of two modes: a submicron fraction composed primarily of ammonium/acid sulfates and elemental black carbon (BC) and a supermicron fraction composed mainly of quartz and clay minerals of soil origin. Aerosol mass concentrations determined from weekly or biweekly samples are dominated by wind-derived aerosol of soil origin and typically range from almost-equal-to 10 mug m-3 in the fall rainy season (August-October) to almost-equal-to 100 mug m-3 during the spring windy season (February-June). The mass concentration frequency of occurrence of both total aerosol and BC are well approximated lognormal probability distributions. Geometric mean masses of aerosol range from 16 to 32 mug m and are smaller for mountain sites than for basin sites; geometric mean BC mass concentrations at a single basin site are almost-equal-to 0.15 mug m-3. Aerosol loadings decrease slightly from 1975-1977 to 1990 measurement periods, whereas BC concentrations, within statistical error, remain unchanged. However, a statistically significant increase in BC did occur from 1990 to 1991. The fraction of (visible spectrum) aerosol absorption attributable to BC has a yearly mean value of almost-equal-to 0.84, although during dusty conditions occurring in spring or early summer, non-BC aerosol absorption contributes up to almost-equal-to 30% of the total. Sulfate and BC aerosol concentrations are sometimes highly correlated, suggesting they have a common source and may be internally mixed. Limited aircraft measurements in the lowest few kilometers of the troposphere reveal a well-mixed aerosol for a neutral atmospheric condition, and a significant decrease in aerosol concentration with altitude for a stable atmospheric condition. C1 NEW MEXICO STATE UNIV,PHYS SCI LAB,LAS CRUCES,NM 88003. LAWRENCE BERKELEY LAB,BERKELEY,CA 94720. COLORADO STATE UNIV,DEPT ATMOSPHER SCI,FT COLLINS,CO 80523. RP PINNICK, RG (reprint author), ATMOSPHER SCI LAB,WHITE SANDS MISSILE RANGE,NM 88002, USA. NR 51 TC 41 Z9 42 U1 0 U2 8 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 SN 0148-0227 J9 J GEOPHYS RES-ATMOS JI J. Geophys. Res.-Atmos. PD FEB 20 PY 1993 VL 98 IS D2 BP 2651 EP 2666 DI 10.1029/92JD02211 PG 16 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA KN689 UT WOS:A1993KN68900006 ER PT J AU ANDRADE, F BRASSARD, JM ANZUETO, A MAXWELL, LC LEVINE, SM LAWRENCE, RA JENKINSON, SG AF ANDRADE, F BRASSARD, JM ANZUETO, A MAXWELL, LC LEVINE, SM LAWRENCE, RA JENKINSON, SG TI EFFECTS OF RESISTIVE BREATHING IN RAT DIAPHRAGM (DPH) FUNCTION AFTER NORMOBARIC HYPEROXIA SO FASEB JOURNAL LA English DT Meeting Abstract C1 UNIV TEXAS,HLTH SCI CTR,SAN ANTONIO,TX 78284. AUDIE L MURPHY MEM VET ADM MED CTR,SAN ANTONIO,TX 78284. BROOKE ARMY MED CTR,SAN ANTONIO,TX 78284. RI Andrade, Francisco/F-1258-2011 OI Andrade, Francisco/0000-0002-2460-5798 NR 0 TC 1 Z9 1 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 19 PY 1993 VL 7 IS 3 BP A222 EP A222 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA KP974 UT WOS:A1993KP97401284 ER PT J AU ANDRON, L CHU, CS MCMANUS, AT MASON, AD PRUITT, BA AF ANDRON, L CHU, CS MCMANUS, AT MASON, AD PRUITT, BA TI SILVER NYLON (SN) DRESSINGS REDUCE LEAKAGE OF EVANS BLUE DYE-ALBUMIN (EBA) INTO BURN WOUNDS SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,INST SURG RES,SAN ANTONIO,TX 78234. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 19 PY 1993 VL 7 IS 3 BP A242 EP A242 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA KP974 UT WOS:A1993KP97401396 ER PT J AU BAKERFULCO, CJ ASKEW, EW AF BAKERFULCO, CJ ASKEW, EW TI DIETARY ASSESSMENTS OF MILITARY POPULATIONS SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 19 PY 1993 VL 7 IS 3 BP A411 EP A411 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA KP974 UT WOS:A1993KP97402377 ER PT J AU BOUSHEL, R FULCO, CS LYONS, T LEWIS, SF CYMERMAN, A AF BOUSHEL, R FULCO, CS LYONS, T LEWIS, SF CYMERMAN, A TI FOREARM BLOOD-FLOW AT REST AND DURING LEG EXERCISE BEFORE, DURING, AND AFTER EXPOSURE TO ALTITUDE (4300 M) SO FASEB JOURNAL LA English DT Meeting Abstract C1 BOSTON UNIV,SARGENT COLL ALLIED HLTH PROFESS,DEPT HLTH SCI,BOSTON,MA 02215. USA,ENVIRONM MED RES INST,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 19 PY 1993 VL 7 IS 3 BP A448 EP A448 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA KP974 UT WOS:A1993KP97402590 ER PT J AU BOWERS, W BLAHA, M SANKOVICH, J AF BOWERS, W BLAHA, M SANKOVICH, J TI HUMAN-CELLS IN LIVING SKIN EQUIVALENT (LSE) RELEASE PROSTAGLANDIN-E2 (PGE2) AND INTERLEUKIN-1-ALPHA (IL-1-ALPHA) AFTER FREEZE-THAW INJURY SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 19 PY 1993 VL 7 IS 3 BP A357 EP A357 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA KP974 UT WOS:A1993KP97402066 ER PT J AU CHEN, JY TU, A OYEJIDE, A TSENG, J KOMISAR, J HSU, IC AF CHEN, JY TU, A OYEJIDE, A TSENG, J KOMISAR, J HSU, IC TI HISTOPATHOLOGIC FEATURES OF STAPHYLOCOCCAL ENTEROTOXIN-B TOXICOSIS IN ACTINOMYCIN-D-PRIMED MICE SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,WASHINGTON,DC 20307. UNIV MARYLAND,SCH MED,BALTIMORE,MD 21201. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 19 PY 1993 VL 7 IS 3 BP A271 EP A271 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA KP974 UT WOS:A1993KP97401573 ER PT J AU CLAYBAUGH, JR UYEHARA, CFT SATO, AK MATSUDA, LS AF CLAYBAUGH, JR UYEHARA, CFT SATO, AK MATSUDA, LS TI RENIN INHIBITION AND ALDOSTERONE STIMULATION BY LYSINE VASOPRESSIN AND V1-AGONIST INFUSION IN NEONATAL PIGLETS SO FASEB JOURNAL LA English DT Meeting Abstract C1 TRIPLER ARMY MED CTR,HONOLULU,HI 96859. KAPIOLANI MED CTR,HONOLULU,HI. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 19 PY 1993 VL 7 IS 3 BP A434 EP A434 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA KP974 UT WOS:A1993KP97402508 ER PT J AU DECOSTER, MA TORTELLA, FC AF DECOSTER, MA TORTELLA, FC TI APPEARANCE OF BASAL CALCIUM OSCILLATIONS IN DEVELOPING NEURONAL CULTURES SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,NEUPHRM BR,WASHINGTON,DC 20307. NR 0 TC 1 Z9 1 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 19 PY 1993 VL 7 IS 3 BP A32 EP A32 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA KP974 UT WOS:A1993KP97400179 ER PT J AU DUBOSE, DA HINKLE, JR MOREHOUSE, DH AF DUBOSE, DA HINKLE, JR MOREHOUSE, DH TI HYPERTHERMIC EFFECTS ON BOVINE AORTIC ENDOTHELIAL-CELL (BAEC) PERMEABILITY AND CYTOSKELETAL F-ACTIN SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 19 PY 1993 VL 7 IS 3 BP A128 EP A128 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA KP974 UT WOS:A1993KP97400740 ER PT J AU DURKOT, MJ FRANCESCONI, R DEGARAVILLA, L AF DURKOT, MJ FRANCESCONI, R DEGARAVILLA, L TI THERMOREGULATORY AND METABOLIC RESPONSES TO AN ADENOSINE-A1 ANTAGONIST DURING EXERCISE IN THE HEAT SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,RIEM,NATICK,MA 01760. NOVA PHARMACEUT,BALTIMORE,MD 21224. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 19 PY 1993 VL 7 IS 3 BP A452 EP A452 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA KP974 UT WOS:A1993KP97402613 ER PT J AU EICHINGER, MR CLAYBAUGH, JR AF EICHINGER, MR CLAYBAUGH, JR TI HORMONAL RESPONSES TO HYPOTENSION DURING HYPOXIA IN THE CONSCIOUS GOAT SO FASEB JOURNAL LA English DT Meeting Abstract C1 UNIV HAWAII,DEPT PHYSIOL,HONOLULU,HI 96822. TRIPLER ARMY MED CTR,HONOLULU,HI 96859. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 19 PY 1993 VL 7 IS 3 BP A434 EP A434 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA KP974 UT WOS:A1993KP97402506 ER PT J AU FULCO, CS HELAYHEL, R LEWIS, SF CYMERMAN, A AF FULCO, CS HELAYHEL, R LEWIS, SF CYMERMAN, A TI EFFECT OF ALTITUDE EXPOSURE AND RETURN TO SEA-LEVEL ON VOLUNTARY MUSCLE FUNCTION SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. BOSTON UNIV,SARGENT COLL ALLIED HLTH PROFESS,DEPT HLTH SCI,BOSTON,MA 02215. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 19 PY 1993 VL 7 IS 3 BP A448 EP A448 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA KP974 UT WOS:A1993KP97402589 ER PT J AU KAMIMORI, GH LUGO, SI EDDINGTON, ND AF KAMIMORI, GH LUGO, SI EDDINGTON, ND TI INTER AND INTRA-SUBJECT VARIABILITY OF INDOCYANINE GREEN (ICG) PHARMACOKINETICS (PK) IN MAN SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,DEPT BEHAV BIOL,WASHINGTON,DC 20307. UNIV MD,DEPT PHARMACEUT,BALTIMORE,MD 21201. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 19 PY 1993 VL 7 IS 3 BP A483 EP A483 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA KP974 UT WOS:A1993KP97402798 ER PT J AU KING, N FRIDLUND, KE BEAM, BS ASKEW, EW SZETO, EG ROSE, RW CARLSON, DE AF KING, N FRIDLUND, KE BEAM, BS ASKEW, EW SZETO, EG ROSE, RW CARLSON, DE TI NUTRITIONAL INTAKES OF MINORITY-GROUPS IN THE UNITED-STATES-ARMY SO FASEB JOURNAL LA English DT Meeting Abstract C1 OFF SURGEON GEN,WASHINGTON,DC. USA,ENVIRONM MED RES INST,DIV MIL NUTR,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 19 PY 1993 VL 7 IS 3 BP A292 EP A292 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA KP974 UT WOS:A1993KP97401692 ER PT J AU LIU, CT GUO, ZM AF LIU, CT GUO, ZM TI CHANGES IN CARDIAC CHAMBER PRESSURES - POSSIBLE MECHANISMS OF PICHINDE VIRUS-INDUCED PULMONARY-EDEMA SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,INFECT DIS RES INST,FT DETRICK,MD 21702. NR 0 TC 3 Z9 3 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 19 PY 1993 VL 7 IS 3 BP A109 EP A109 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA KP974 UT WOS:A1993KP97400629 ER PT J AU MATSUDA, LS UYEHARA, CFT AF MATSUDA, LS UYEHARA, CFT TI RENAL SODIUM HANDLING DURING THE EARLY PHASE OF HYPERTENSION DEVELOPMENT IN SPONTANEOUSLY HYPERTENSIVE RATS SO FASEB JOURNAL LA English DT Meeting Abstract C1 TRIPLER ARMY MED CTR,HONOLULU,HI 96859. KAPIOLANI MED CTR,HONOLULU,HI. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 19 PY 1993 VL 7 IS 3 BP A6 EP A6 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA KP974 UT WOS:A1993KP97400033 ER PT J AU MATTHEW, C DURKOT, M PATTERSON, D AF MATTHEW, C DURKOT, M PATTERSON, D TI FLUID SHIFTS INDUCED BY 7.5-PERCENT SODIUM-CHLORIDE IN 6-PERCENT DEXTRAN-70 (HSD) IN DEHYDRATED SWINE SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 19 PY 1993 VL 7 IS 3 BP A443 EP A443 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA KP974 UT WOS:A1993KP97402560 ER PT J AU MEIER, HL KELLY, SA CORUN, CM AF MEIER, HL KELLY, SA CORUN, CM TI A COMPARISON OF CYTOTOXICITY OF LEWISITE AND SULFUR MUSTARD IN HUMAN LYMPHOCYTE PREPARATIONS SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 19 PY 1993 VL 7 IS 3 BP A37 EP A37 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA KP974 UT WOS:A1993KP97400211 ER PT J AU MOORE, RJ FRIEDL, KE TULLEY, RT ASKEW, EW AF MOORE, RJ FRIEDL, KE TULLEY, RT ASKEW, EW TI NORMAL IRON (FE) STATUS DURING PHYSICAL-TRAINING WITH LOW FE INTAKE AND RAPID WEIGHT-LOSS SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. PENNINGTON BIOMED RES CTR,BATON ROUGE,LA 70808. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 19 PY 1993 VL 7 IS 3 BP A517 EP A517 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA KP974 UT WOS:A1993KP97402997 ER PT J AU MURPHY, C OTTO, D LONG, C HEIMBURGER, D GEIGER, J AF MURPHY, C OTTO, D LONG, C HEIMBURGER, D GEIGER, J TI EFFECTS OF INTRADIALYTIC PARENTERAL-NUTRITION (IDPN) ON ORAL INTAKE AND WHOLE-BODY PROTEIN-TURNOVER (WBPT) IN UNDERWEIGHT HEMODIALYSIS (HD) PATIENTS SO FASEB JOURNAL LA English DT Meeting Abstract C1 PRINCETON BAPTIST MED CTR,BIRMINGHAM,AL 35211. UNIV AL BIRMINGHAM,BIRMINGHAM,AL 35219. USA,ENVIRONM MED RES INST,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 19 PY 1993 VL 7 IS 3 BP A377 EP A377 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA KP974 UT WOS:A1993KP97402178 ER PT J AU PAUSTIAN, PW CHUANG, AH RUNNER, RR MCPHERSON, JC MCPHERSON, JC AF PAUSTIAN, PW CHUANG, AH RUNNER, RR MCPHERSON, JC MCPHERSON, JC TI COMPARISON OF POLOXAMER-188 AND POLOXAMER-407 ON EARLY BURN WOUND CONTRACTION SO FASEB JOURNAL LA English DT Meeting Abstract C1 MED COLL GEORGIA,AUGUSTA,GA 30912. EISENHOWER ARMY MED CTR,DEPT CLIN INVEST,FT GORDON,GA 30905. NR 0 TC 0 Z9 0 U1 1 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 19 PY 1993 VL 7 IS 3 BP A139 EP A139 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA KP974 UT WOS:A1993KP97400803 ER PT J AU PEARCE, FJ VANALBERT, S WIESMANN, W AF PEARCE, FJ VANALBERT, S WIESMANN, W TI COMPUTER-CONTROLLED SERVOMECHANISM FOR CONTROL OF BLOOD-PRESSURE (BP) IN ISOBARIC MODELS OF HEMORRHAGIC-SHOCK SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 19 PY 1993 VL 7 IS 3 BP A323 EP A323 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA KP974 UT WOS:A1993KP97401872 ER PT J AU PORTER, DW BASKIN, SI AF PORTER, DW BASKIN, SI TI INVITRO STUDIES OF THE EFFECT OF ALPHA-KETOGLUTARATE AND ALPHA-KETOBUTYRATE ON THE CYANIDE (CN) DETOXIFYING ACTIVITY OF 3-MERCAPTOPYRUVATE SULFUR TRANSFERASE (3-MPST) SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,MED RES INST,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 19 PY 1993 VL 7 IS 3 BP A51 EP A51 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA KP974 UT WOS:A1993KP97400290 ER PT J AU RAY, R MAJERUS, BJ MUNAVALLI, GS PETRALI, JP AF RAY, R MAJERUS, BJ MUNAVALLI, GS PETRALI, JP TI INTRACELLULAR CALCIUM CHANGES DUE TO SULFUR MUSTARD SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 19 PY 1993 VL 7 IS 3 BP A37 EP A37 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA KP974 UT WOS:A1993KP97400210 ER PT J AU STEPHENSON, LA BLANCHARD, LA LEVINE, L ROCK, PB KOLKA, MA AF STEPHENSON, LA BLANCHARD, LA LEVINE, L ROCK, PB KOLKA, MA TI PEAK AEROBIC POWER (PEAK VO2) DURING ADJUVANT BREAST-CANCER THERAPY SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 19 PY 1993 VL 7 IS 3 BP A450 EP A450 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA KP974 UT WOS:A1993KP97402604 ER PT J AU THOMAS, C FRIEDL, K MAYS, M ASKEW, W AF THOMAS, C FRIEDL, K MAYS, M ASKEW, W TI EFFECT OF EXTENDED CONSUMPTION OF MEAL, READY-TO-EAT ON NUTRITIONAL-STATUS AND PERFORMANCE OF SOLDIERS SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. NR 0 TC 1 Z9 1 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 19 PY 1993 VL 7 IS 3 BP A295 EP A295 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA KP974 UT WOS:A1993KP97401705 ER PT J AU UYEHARA, CFT CLAYBAUGH, JR MATSUDA, LS SATO, AK VANSCOY, SC AF UYEHARA, CFT CLAYBAUGH, JR MATSUDA, LS SATO, AK VANSCOY, SC TI VASOPRESSIN (VP) IMPROVES BLOOD-GAS EXCHANGE IN NEONATAL PIGLETS VIA V1-RECEPTOR STIMULATION SO FASEB JOURNAL LA English DT Meeting Abstract C1 TRIPLER ARMY MED CTR,HONOLULU,HI 96859. KAPIOLANI MED CTR,HONOLULU,HI. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 19 PY 1993 VL 7 IS 3 BP A434 EP A434 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA KP974 UT WOS:A1993KP97402510 ER PT J AU YOUNG, GD ANDERSON, DR YOURICK, JJ AF YOUNG, GD ANDERSON, DR YOURICK, JJ TI ACUTE PATHOLOGICAL EFFECTS OF TRANSTRACHEAL HD INHALATION IN RATS SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA SN 0892-6638 J9 FASEB J JI Faseb J. PD FEB 19 PY 1993 VL 7 IS 3 BP A505 EP A505 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA KP974 UT WOS:A1993KP97402927 ER PT J AU HORNBACH, DJ DENEKA, T HU, M PAYNE, BS MILLER, AC AF HORNBACH, DJ DENEKA, T HU, M PAYNE, BS MILLER, AC TI TEMPORAL AND SPATIAL VARIABILITY IN MIDGE ASSEMBLAGES FROM A BACKWATER LAKE IN POOL-2, MISSISSIPPI RIVER SO HYDROBIOLOGIA LA English DT Article ID CHIRONOMIDAE; SEDIMENT; DIPTERA; RATES AB The temporal and spatial variability in the midge assemblage found in a backwater lake of the Mississippi River was examined. Bi-weekly samples were taken during the summers of 1987 and 1988. Four taxa of chironomids were found. The population density and sizes of chironomids, and the proportion that each taxon comprised of the midge assemblage, varied significantly in time and space. In an attempt to examine whether the variability noted was related to sediment accretion in the lake, sedimentation rates were measured. There were few correlations among sedimentation rate or the organic matter content of the collected sediment and the structure of the midge assemblage. Those few correlations that were statistically significant were low and often paradoxical. For example negative relationships were found between the density and size of Chironomus spp., a detritivore, and the amount of sediment deposited or its organic matter content. Also no significant relationships were found between the density of the predator Cryptochironomus spp. and the density of other chironomids (potential prey). These negative findings indicate that factors other than food, such as sediment texture, may be more important than food availability in structuring chironomid assemblages in backwater areas. There was spatial variability in the densities and sizes of chironomids that may be explained by differences in sediment texture and organic matter. This suggests that short-term inputs of sediment (as ascertained by sediment traps) may not greatly influence midge assemblages while the long-term changes in sediment composition may have large influences. C1 USA,CORPS ENGINEERS,WATERWAYS EXPT STN,VICKSBURG,MS 39180. RP HORNBACH, DJ (reprint author), MACALESTER COLL,DEPT BIOL,ST PAUL,MN 55105, USA. NR 18 TC 4 Z9 4 U1 1 U2 4 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 0018-8158 J9 HYDROBIOLOGIA JI Hydrobiologia PD FEB 19 PY 1993 VL 252 IS 2 BP 133 EP 141 DI 10.1007/BF00008151 PG 9 WC Marine & Freshwater Biology SC Marine & Freshwater Biology GA KY419 UT WOS:A1993KY41900002 ER PT J AU TAPSON, KMP AF TAPSON, KMP TI HENOCH-SCHONLEIN PURPURA SO AMERICAN FAMILY PHYSICIAN LA English DT Article AB Henoch-Schonlein purpura is a small vessel vasculitic disease thought to be caused by an immunoglobulin-mediated inflammatory process resulting from immune complex reaction to antigenic stimuli. It is a relatively common disease that will be encountered in the clinical practice of most family physicians. Although it occurs most frequently in children, it can occur in all age groups. It is classically manifested by palpable purpura on the lower extremities, abdominal pain, arthritis and renal involvement. Family physicians should be familiar with the disease's clinical manifestations and be aware of potentially serious complications that may affect long-term prognosis and management. RP TAPSON, KMP (reprint author), USA,SILAS B HAYS COMMUNITY HOSP,FT ORD,CA, USA. NR 0 TC 5 Z9 5 U1 0 U2 0 PU AMER ACAD FAMILY PHYSICIANS PI KANSAS CITY PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 SN 0002-838X J9 AM FAM PHYSICIAN JI Am. Fam. Physician PD FEB 15 PY 1993 VL 47 IS 3 BP 633 EP 638 PG 6 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA KN938 UT WOS:A1993KN93800012 PM 8434554 ER PT J AU EBERSOLE, DG HEIRONIMUS, J TONEY, MO BILLINGSLEY, J AF EBERSOLE, DG HEIRONIMUS, J TONEY, MO BILLINGSLEY, J TI COMPARISON OF EXERCISE AND ADENOSINE TC-99M SESTAMIBI MYOCARDIAL SCINTIGRAPHY FOR DIAGNOSIS OF CORONARY-ARTERY DISEASE IN PATIENTS WITH LEFT-BUNDLE-BRANCH BLOCK SO AMERICAN JOURNAL OF CARDIOLOGY LA English DT Note ID EMISSION COMPUTED-TOMOGRAPHY; TL-201 SCINTIGRAPHY; DIPYRIDAMOLE C1 BROOKE ARMY MED CTR,DEPT NUCL MED,FT SAM HOUSTON,TX 78234. RP EBERSOLE, DG (reprint author), BROOKE ARMY MED CTR,CARDIOL SERV,FT SAM HOUSTON,TX 78234, USA. NR 10 TC 24 Z9 24 U1 0 U2 0 PU EXCERPTA MEDICA INC PI NEW YORK PA 245 WEST 17TH STREET, NEW YORK, NY 10011 SN 0002-9149 J9 AM J CARDIOL JI Am. J. Cardiol. PD FEB 15 PY 1993 VL 71 IS 5 BP 450 EP 453 DI 10.1016/0002-9149(93)90453-J PG 4 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA KM552 UT WOS:A1993KM55200019 PM 8430639 ER PT J AU PARK, RC THIGPEN, JT AF PARK, RC THIGPEN, JT TI CHEMOTHERAPY IN ADVANCED AND RECURRENT CERVICAL-CANCER - A REVIEW SO CANCER LA English DT Article; Proceedings Paper CT 4TH NATIONAL CONF OF THE AMERICAN CANCER SOC : GYNECOLOGIC CANCERS CY APR 02-04, 1992 CL ORLANDO, FL SP AMER CANC SOC, AMER ACAD FAMILY PHYSICIANS, AMER COLL OBSTETRICIANS & GYNECOLOGISTS, AMER COLL RADIAT ONCOL, AMER COLL RADIOL, AMER COLL SURGEONS, COMMISS CANC, AMER RADIUM SOC, AMER SOC THERAPEUT RADIOL & ONCOL, NATL ASSOC ONCOL SOCIAL WORKERS, NATL ASSOC SOCIAL WORKERS DE CHEMOTHERAPY; CERVICAL CANCER; ADVANCED; RECURRENT ID GYNECOLOGIC-ONCOLOGY-GROUP; SQUAMOUS-CELL-CARCINOMA; PHASE-II TRIAL; UTERINE CERVIX; ICRF-159 RAZOXANE; RANDOMIZED TRIAL; CISPLATIN; CYCLOPHOSPHAMIDE; VINCRISTINE; MANAGEMENT AB Background. Despite the success of cytologic techniques in the diagnosis of neoplastic changes in the epithelium of the uterine cervix and the resultant decrease in the incidence of cervical invasive malignancies, 4440 women in this country will die of cervical cancer in 1992. Although radiation therapy and surgery form the basis for treatment of disease limited to the pelvis, those who have advanced disease or recurrences after locoregional therapy depend on systemic treatment for any hope of disease control. Method. Patients with advanced disease (not curable by surgery and/or irradiation) and recurrent cervical cancer have received single and combination cytotoxic chemotherapeutic regimens. Results. Thirty-eight cytotoxic agents alone and in combination have been reported. Although none have produced a significant number of cures, several have shown moderate activity. Of particular interest, because of the relatively high response rates and carefully done trials, are cisplatin, ifosfamide, and dibromodulcitol with partial and complete response rates of 23%, 22%, and 22%, respectively. Currently, no combinations have been shown to be better than single agents. Conclusions. No chemotherapy for advanced or recurrent carcinoma of the cervix is more effective than single-agent cisplatin. The major thrust of current and future investigation seeks to identify additional active agents and to develop combinations that offer greater patient benefit. C1 UNIV MISSISSIPPI,MED CTR,JACKSON,MS 39216. RP PARK, RC (reprint author), WALTER REED ARMY MED CTR,DEPT OBSTET GYNECOL,GYNECOL ONCOL GRP,WASHINGTON,DC 20307, USA. NR 43 TC 50 Z9 50 U1 0 U2 1 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0008-543X J9 CANCER JI Cancer PD FEB 15 PY 1993 VL 71 IS 4 SU S BP 1446 EP 1450 PG 5 WC Oncology SC Oncology GA KN467 UT WOS:A1993KN46700008 PM 8431878 ER PT J AU BLANEY, SM COLE, DE BALIS, FM GODWIN, K POPLACK, DG AF BLANEY, SM COLE, DE BALIS, FM GODWIN, K POPLACK, DG TI PLASMA AND CEREBROSPINAL-FLUID PHARMACOKINETIC STUDY OF TOPOTECAN IN NONHUMAN-PRIMATES SO CANCER RESEARCH LA English DT Note ID DRUGS; MODEL AB Topotecan, a water soluble semisynthetic analogue of camptothecin, is a topoisomerase I inhibitor that has recently entered phase II clinical trials. Topotecan has shown significant preclinical activity in refractory murine tumors and in human tumor xenograft models. In addition, objective antineoplastic activity has been observed in recent adult phase I clinical trials. Topotecan is unstable in solution and is rapidly and spontaneously converted to a less active open ring form which predominates at physiological pH. This study was undertaken to better define the pharmacokinetic behavior of this highly unstable compound in both plasma and cerebrospinal fluid (CSF) and to measure the degree of CSF penetration of this novel antineoplastic agent. Three nonhuman primates with indwelling Ommaya reservoirs received 10 mg/m2 i.v. topotecan administered as a 10-min infusion. Frequent plasma and CSF samples were obtained and immediately extracted and assayed with a reverse phase high performance liquid chromatography assay to quantitate the concentration of topotecan lactone). Samples were then acidified and reinjected to quantitate total drug (lactone ring plus open ring). Peak plasma concentrations of topotecan ranged from 0.27 to 0.45 muM. Plasma disappearance of the lactone ring was biexponential with a distribution half-life (t1/2alpha) of 22 +/- 5 min and an elimination half-life (t1/2beta) Of 1.3 +/- 0.1 h. Total body clearance of topotecan was 72.1 +/- 15.8 liters/h/m2. The volume of distribution at steady state was 88.6 +/- 33.2 liter/m2. Peak CSF concentrations of topotecan occurred at 30 min following drug administration and ranged from 0.044 to 0.074 muM. CSF disappearance paralleled that in plasma. The mean ratio of the area under the CSF concentration-time curve to that in plasma was 0.32 (range, 0.29 to 0.37). The mean CSF penetration of topotecan exceeds 30%, which is significantly greater than the penetration of most structurally similar chemotherapeutic agents. The impact of chemotherapy on the survival of patients with primary or metastatic central nervous system malignancies is very limited. Therefore, this novel antineoplastic agent is an excellent candidate for further study in patients with high risk or refractory central nervous system tumors. C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. RP BLANEY, SM (reprint author), NCI,PEDIAT BRANCH,BETHESDA,MD 20892, USA. NR 22 TC 80 Z9 81 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA PUBLIC LEDGER BLDG, SUITE 816, 150 S. INDEPENDENCE MALL W., PHILADELPHIA, PA 19106 SN 0008-5472 J9 CANCER RES JI Cancer Res. PD FEB 15 PY 1993 VL 53 IS 4 BP 725 EP 727 PG 3 WC Oncology SC Oncology GA KL963 UT WOS:A1993KL96300005 PM 8428353 ER PT J AU ALVING, BM AF ALVING, BM TI THE HYPERCOAGULABLE STATES SO HOSPITAL PRACTICE LA English DT Article AB In most cases, acute venous thrombosis has a straightforward etiology-for example, the patient who has had prolonged bed rest with a broken leg and received no heparin. A significant minority of patients, however, have an inherited biochemical deficiency or an acquired disorder that increases the risk of thrombosis. Some general guidelines suggest when to suspect such defects and what tests to apply. RP ALVING, BM (reprint author), WALTER REED ARMY INST RES,DEPT HEMATOL,WASHINGTON,DC 20307, USA. NR 0 TC 20 Z9 20 U1 0 U2 1 PU MCGRAW HILL HEALTHCARE PUBLICATIONS PI MINNEAPOLIS PA 4530 WEST 77TH ST, MINNEAPOLIS, MN 55435-5000 SN 8750-2836 J9 HOSP PRACT JI Hosp. Pract. PD FEB 15 PY 1993 VL 28 IS 2 BP 109 EP & PG 0 WC Medicine, General & Internal SC General & Internal Medicine GA KM170 UT WOS:A1993KM17000009 PM 8432749 ER PT J AU DUTTA, M STROSCIO, MA AF DUTTA, M STROSCIO, MA TI INTERFACE-PHONON-ASSISTED GAMMA-X TRANSITIONS IN SHORT-PERIOD SUPERLATTICES SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID SEMICONDUCTOR HETEROINTERFACES; MINIBAND STRUCTURE; ENVELOPE FUNCTIONS; QUANTUM-WELLS; HETEROSTRUCTURES; CONNECTION AB The dielectric continuum model of longitudinal-optical phonons in polar semiconductors is used to define the role of interface longitudinal-optical phonons- in affecting phonon-assisted GAMMA-x transitions in GaAs-AlAs and GaAs-GaP superlattices. In particular, the dielectric continuum model for interface optical phonons is used in conjunction with a Kronig-Penney model of the superlattice electronic properties for two purposes: to specify superlattice parameters where interface-phonon-assisted GAMMA-X transitions are expected and to estimate relative transition probability amplitudes for interface-phonon-assisted GAMMA-x transitions in selected short-period superlattices. C1 USA,RES OFF,RES TRIANGLE PK,NC 27709. RP DUTTA, M (reprint author), USA,RES LAB,ELECTR & POWER SOURCES DIRECTORATE,FT MONMOUTH,NJ 07703, USA. NR 22 TC 3 Z9 3 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD FEB 15 PY 1993 VL 73 IS 4 BP 1693 EP 1701 DI 10.1063/1.354060 PG 9 WC Physics, Applied SC Physics GA KM233 UT WOS:A1993KM23300020 ER PT J AU GRUBER, JB SELTZER, MD HILLS, ME STEVENS, SB MORRISON, CA AF GRUBER, JB SELTZER, MD HILLS, ME STEVENS, SB MORRISON, CA TI ENERGY-LEVELS AND UP-CONVERSION FLUORESCENCE IN TRIVALENT THULIUM-DOPED YTTRIUM SCANDIUM ALUMINUM GARNET SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID LASERS; GROWTH; CW AB Absorption spectra of Tm3+ ions in Yttrium scandium aluminum garnet are reported between 1.9 and 0.25 mum at 4 K. Laser-excited fluorescence was observed at 4 K from Tm3+ (4f12) multiplet manifolds 1D2, 1G4, F-3(2), and H-3(4) to the ground-state manifold H-3(6). Emission from 1D2 and 1G4 also includes transitions to Stark levels in manifolds F-3(4) and H-3(5). Upconversion excited fluorescence was observed between 1D2 and F-3(4) at 10 K. Analysis of the fluorescence emission confirms assignments given to individual Stark levels based on an analysis of the absorption spectra. A crystal-field splitting calculation was carried out in which a parameterized Hamiltonian (including Coulombic, spin-orbit, and crystal-field terms in D2 symmetry) was diagonalized for all multiplets of the Tm3+ (4f12) configuration. The rms deviation between 42 experimental and calculated Stark levels was 8 cm-1. C1 USN,CTR AIR WARFARE,DIV WEAP,RES DEPT,DIV CHEM,CHINA LAKE,CA 93555. USA,ADELPHI LAB CTR,HARRY DIAMOND LABS,ADELPHI,MD 20375. RP GRUBER, JB (reprint author), SAN JOSE STATE UNIV,DEPT PHYS,SAN JOSE,CA 95192, USA. NR 16 TC 18 Z9 18 U1 0 U2 7 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD FEB 15 PY 1993 VL 73 IS 4 BP 1929 EP 1935 DI 10.1063/1.354080 PG 7 WC Physics, Applied SC Physics GA KM233 UT WOS:A1993KM23300055 ER PT J AU DESPER, CR COHEN, SH KING, AO AF DESPER, CR COHEN, SH KING, AO TI MORPHOLOGICAL EFFECTS OF BALLISTIC IMPACT ON FABRICS OF HIGHLY DRAWN POLYETHYLENE FIBERS SO JOURNAL OF APPLIED POLYMER SCIENCE LA English DT Article AB Changes in crystalline structure of high-tenacity ultra-high-molecular-weight polyethylene fabric brought on by ballistic impact from a small projectile were determined by X-ray diffractometry. A suitable X-ray diffraction method that averages out the fiber orientation effects in the diffraction pattern was used. The Spectra 1000(TM) polyethylene fabrics were successfully characterized in terms of both the predominant orthorhombic and the minor monoclinic crystal content. Crystallinity values for the undamaged fabric are consistent from sample to sample and show an average orthorhombic fraction of 0.61 and an average monoclinic fraction of 0.04. Fabric damage by the projectile impact results in either an increase in monoclinic fraction, attributed to recrystallization at temperatures nearing the normal polyethylene melting point, or disappearance of monoclinic material as that temperature is exceeded. The latter predominates where ballistic penetration is complete. However, actual melting need not be involved: Transformation to the hexagonal (''rotator'') phase and the disappearance of the monoclinic phase could have occurred rather than true melting. C1 USA,NATICK RES DEV & ENGN CTR,NATICK,MA 01065. RP DESPER, CR (reprint author), USA,MAT TECHNOL LAB,WATERTOWN,MA 02172, USA. NR 17 TC 9 Z9 10 U1 0 U2 7 PU JOHN WILEY & SONS INC PI NEW YORK PA 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0021-8995 J9 J APPL POLYM SCI JI J. Appl. Polym. Sci. PD FEB 15 PY 1993 VL 47 IS 7 BP 1129 EP 1142 DI 10.1002/app.1993.070470701 PG 14 WC Polymer Science SC Polymer Science GA KH414 UT WOS:A1993KH41400001 ER PT J AU OLSEN, RJ EPSTEIN, IR AF OLSEN, RJ EPSTEIN, IR TI BIFURCATION-ANALYSIS OF CHEMICAL-REACTION MECHANISMS .2. HOPF-BIFURCATION ANALYSIS SO JOURNAL OF CHEMICAL PHYSICS LA English DT Article ID CHLORITE IODIDE REACTION; ISOLATED PERIODIC-SOLUTIONS; STIRRED TANK REACTORS; SYSTEMATIC DESIGN; DYNAMICAL BEHAVIOR; OSCILLATORS; MODEL; CLASSIFICATION; UNFOLDINGS; KINETICS AB One- and two-parameter Hopf bifurcation behavior is analyzed for several variants of the Citri-Epstein mechanism of the chlorite-iodide reaction. The coefficients of an equation for the amplitude of oscillations (the universal unfolding of the Hopf bifurcation) are evaluated numerically. Local bifurcation diagrams and bifurcation sets are derived from the amplitude equation. Sub- and supercritical Hopf bifurcations are identified for the general case of a nondegenerate (codimension one) bifurcation. At degenerate (codimension two) points, the necessary higher-order terms are included in the unfolding, and features such as locally isolated branches of periodic orbits and bistability of a periodic orbit and a steady state are found. Inferences about the global periodic orbit structure and the existence of nearby codimension three Hopf bifurcation points are drawn by piecing together the local information contained in the unfoldings. Hypotheses regarding the global periodic orbit structure are tested using continuation methods to compute entire branches of orbits. A thorough discussion of the application of these methods is presented for one version of the mechanism, followed by a comparison of the complete two-parameter steady state bifurcation structure of three versions of the mechanism. In all cases, the potential for experimental verification of the predicted dynamics is examined. C1 UNIV MINNESOTA,ARMY HIGH PERFORMANCE COMP RES CTR,MINNEAPOLIS,MN 55455. BRANDEIS UNIV,DEPT CHEM,WALTHAM,MA 02254. RP OLSEN, RJ (reprint author), UNIV MINNESOTA,DEPT CHEM ENGN & MAT SCI,MINNEAPOLIS,MN 55455, USA. NR 50 TC 13 Z9 13 U1 0 U2 1 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-9606 J9 J CHEM PHYS JI J. Chem. Phys. PD FEB 15 PY 1993 VL 98 IS 4 BP 2805 EP 2822 DI 10.1063/1.465049 PG 18 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA KP938 UT WOS:A1993KP93800032 ER PT J AU MUMM, AH MORENS, DM ELM, JL DIWAN, AR AF MUMM, AH MORENS, DM ELM, JL DIWAN, AR TI ZOSTER AFTER SHIATSU MASSAGE SO LANCET LA English DT Letter C1 UNIV HAWAII,SCH MED,DEPT TROP MED & MED MICROBIOL,HONOLULU,HI 96816. RP MUMM, AH (reprint author), TRIPLER ARMY MED CTR,PREVENT MED SERV,HONOLULU,HI 96859, USA. NR 4 TC 6 Z9 6 U1 0 U2 0 PU LANCET LTD PI LONDON PA 42 BEDFORD SQUARE, LONDON, ENGLAND WC1B 3SL SN 0140-6736 J9 LANCET JI Lancet PD FEB 13 PY 1993 VL 341 IS 8842 BP 447 EP 447 DI 10.1016/0140-6736(93)93052-3 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA KM416 UT WOS:A1993KM41600064 PM 8094222 ER PT J AU LU, Y HALL, T GAY, LS DONELSON, JE AF LU, Y HALL, T GAY, LS DONELSON, JE TI POINT MUTATIONS ARE ASSOCIATED WITH A GENE DUPLICATION LEADING TO THE BLOOD-STREAM REEXPRESSION OF A TRYPANOSOME METACYCLIC VSG SO CELL LA English DT Article ID SURFACE GLYCOPROTEIN GENE; VARIABLE ANTIGEN TYPES; BRUCEI-RHODESIENSE; BLOOD-STREAM; EXPRESSION; CONVERSION; DNA; TRANSCRIPTION; PSEUDOGENES; EQUIPERDUM AB African trypanosomes evade the immune response of their hosts by sequentially expressing different variant surface glycoproteins (VSGs). We isolated a bloodstream trypanosome clone of Trypanosoma brucei rhodesiense that expresses a VSG normally present during the metacyclic stage of the parasite in the insect vector. Associated with the bloodstream reexpression of this metacyclic VSG is a gene conversion in which the duplicated, expressed gene of 1650 nt contains 11 scattered point mutations when compared with its donor gene. Analysis of an uncloned population of bloodstream trypanosomes revealed another VSG reexpressor of the same donor gene in which the coding region had undergone 24 point mutations. The mutations are unique to the duplicated gene and appear to be nontemplated. The generation of these mutations provides a way for the trypanosome to increase further its antigenic diversity. C1 UNIV IOWA,DEPT BIOCHEM,IOWA CITY,IA 52242. HOWARD HUGHES MED INST,IOWA CITY,IA 52242. WALTER REED ARMY INST RES,DEPT IMMUNOL,DIV COMMUNICABLE DIS & IMMUNOL,WASHINGTON,DC 20307. RP LU, Y (reprint author), UNIV IOWA,GENET PHD PROGRAM,IOWA CITY,IA 52242, USA. RI Donelson, John/F-5795-2010 NR 36 TC 46 Z9 46 U1 0 U2 0 PU CELL PRESS PI CAMBRIDGE PA 1050 MASSACHUSETTES AVE, CIRCULATION DEPT, CAMBRIDGE, MA 02138 SN 0092-8674 J9 CELL JI Cell PD FEB 12 PY 1993 VL 72 IS 3 BP 397 EP 406 DI 10.1016/0092-8674(93)90116-8 PG 10 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA KM162 UT WOS:A1993KM16200009 PM 8381717 ER PT J AU JUTAMULIA, S STORTI, GM SEIDERMAN, W LINDMAYER, J GREGORY, DA AF JUTAMULIA, S STORTI, GM SEIDERMAN, W LINDMAYER, J GREGORY, DA TI USE OF ELECTRON-TRAPPING MATERIALS IN OPTICAL SIGNAL-PROCESSING .4. PARALLEL INCOHERENT IMAGE SUBTRACTION SO APPLIED OPTICS LA English DT Note ID REAL-TIME AB Novel electron trapping materials are inherently capable of performing subtraction over a wide dynamic range. The application of the electron trapping materials to parallel incoherent image subtraction is described in detail, and experimental result are presented. C1 KOWA CO LTD, SAN JOSE, CA 95112 USA. USA, MISSILE COMMAND, RES DIRECTORATE, REDSTONE ARSENAL, AL 35898 USA. RP JUTAMULIA, S (reprint author), QUANTEX CORP, 2 RES COURT, ROCKVILLE, MD 20850 USA. NR 11 TC 12 Z9 13 U1 0 U2 0 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 0003-6935 J9 APPL OPTICS JI Appl. Optics PD FEB 10 PY 1993 VL 32 IS 5 BP 743 EP 745 PG 3 WC Optics SC Optics GA KL510 UT WOS:A1993KL51000015 PM 20802749 ER PT J AU VALDES, JJ ANIS, NA ELDEFRAWI, MA AF VALDES, JJ ANIS, NA ELDEFRAWI, MA TI BIOSENSORS FOR MONITORING CHEMICAL-POLLUTANTS IN THE ENVIRONMENT SO JOURNAL OF CELLULAR BIOCHEMISTRY LA English DT Meeting Abstract C1 UNIV MARYLAND,SCH MED,BALTIMORE,MD 21201. USA,EDGEWOOD CHEM RES & DEV CTR,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 1 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0730-2312 J9 J CELL BIOCHEM JI J. Cell. Biochem. PD FEB 8 PY 1993 SU 17C BP 186 EP 186 PG 1 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA KN466 UT WOS:A1993KN46600633 ER PT J AU DEFRANK, JJ HARVEY, SP AF DEFRANK, JJ HARVEY, SP TI BIOCHEMICAL DEMILITARIZATION OF CHEMICAL WARFARE AGENTS SO JOURNAL OF CELLULAR BIOCHEMISTRY LA English DT Meeting Abstract C1 USA,CTR CHEM RES DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0730-2312 J9 J CELL BIOCHEM JI J. Cell. Biochem. PD FEB 8 PY 1993 SU 17C BP 187 EP 187 PG 1 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA KN466 UT WOS:A1993KN46600635 ER PT J AU LOOMIS, L MANN, F LOPEZ, F REDFIELD, R BIRX, D AF LOOMIS, L MANN, F LOPEZ, F REDFIELD, R BIRX, D TI DIFFERENCES IN IMMUNOLOGICAL RESPONSE BETWEEN PROTEINS DEPENDENT ON RECEPTOR-BINDING - A COMPARISON OF VACCINE THERAPY WITH HIV-1 GP160 OR GP120 IN INFECTED PATIENT VOLUNTEERS SO JOURNAL OF CELLULAR BIOCHEMISTRY LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,HM JACKSON FDN,HIV FDN,ROCKVILLE,MD 20850. WALTER REED ARMY INST RES,DEPT RETROVIRAL RES,ROCKVILLE,MD 20850. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0730-2312 J9 J CELL BIOCHEM JI J. Cell. Biochem. PD FEB 8 PY 1993 SU 17C BP 217 EP 217 PG 1 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA KN466 UT WOS:A1993KN46600732 ER PT J AU BLATT, SP LUCEY, CR BUTZIN, CA HENDRIX, CW LUCEY, DR AF BLATT, SP LUCEY, CR BUTZIN, CA HENDRIX, CW LUCEY, DR TI TOTAL LYMPHOCYTE COUNT AS A PREDICTOR OF ABSOLUTE CD4+ COUNT AND CD4+ PERCENTAGE IN HIV-INFECTED PERSONS SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; HOMOSEXUAL MEN; RISK; COHORT; AIDS; PNEUMONIA; DECLINE; TYPE-1 AB Objective.-To determine whether the total lymphocyte count (TLC) accurately predicts a low absolute CD4+ T-cell count and CD4+ percentage in persons infected with human immunodeficiency virus (HIV). Design.-Retrospective analysis of data collected in the US Air Force HIV Natural History Study. Setting.-Military medical center that performs annual medical evaluation of all HIV-infected US Air Force personnel. Patients.-A total of 828 consecutive patients with no prior history of zidovudine use, evaluated from January 1985 through July 1991. For patients with multiple observations over time, a single data point within each 6-month interval was included in the analysis (N=2866). Measurements and Main Results.-The sensitivity, specificity, and likelihood ratio (LR) of the TLC, in the range of 1.00x10(9)/L to 2.00x10(9)/L, in predicting an absolute CD4+ T-cell count less than 0.20x10(9)/L or a CD4+ percentage less than 20% were calculated. In addition, the LR and pretest probability of significant immunosuppression were used to calculate posttest probabilities of a low CD4+ count for a given TLC value. The LR of the TLC in predicting an absolute CD4+ count <0.20x10(9)/L increased from 2.4 (95% confidence interval, 2.2 to 2.5) for all TLCs less than 2.00x10(9)/L, to 33.2 (95% confidence interval, 24.1 to 45.7) for all TLCs less than 1.00x10(9)/L. The specificity for this prediction increased from 57% to 97% over this range. The LR also increased from 1.4 (95% confidence interval, 1.3 to 1.6) for all TLCs less than 2.00x10(9)/L to 9.7 (95% confidence interval, 7.1 to 13.1) for all TLCs less than 1.00x10(9)/L in predicting a CD4+ percentage less than 20%. Conclusions.-The TLC, between 1.00x10(9)/L and 2.00x10(9)/L, appears to be a useful predictor of significant immunosuppression as measured by a CD4+ T-cell count less than 0.20x10(9)/L in HIV-infected persons. The LR fora given TLC value and the pretest probability of immunosuppression can be used to determine the posttest probability of significant immunosuppression in individual patients. For example, in a patient with a TLC less than 1.50x10(9)/L and a pretest probability of 16%, the posttest probability of a low CD4+ T-cell count increases to 53%. In contrast, a TLC greater than 2.00x10(9)/L in an individual with a pretest probability of 30% will decrease the posttest probability of a low CD4+ T-cell count to less than 4%. Physicians should find these data useful to help predict the risk for opportunistic infection among HIV-infected persons who present with syndromes that are potentially compatible with opportunistic infection but who have not had recent or prior CD4+ T-cell analysis. C1 WILFORD HALL USAF MED CTR,CLIN INVEST DIRECTORATE,LACKLAND AFB,TX 78236. SW FDN BIOMED RES,CTR AIDS RES,SAN ANTONIO,TX 78284. MIL MED CONSORTIUM APPL RETROVIRAL RES,SAN ANTONIO,TX. WALTER REED ARMY MED CTR,GEN MED SERV,WASHINGTON,DC 20307. RP BLATT, SP (reprint author), WILFORD HALL USAF MED CTR,DEPT MED,INFECT DIS SERV,HIV PROGRAM,SGHMMI HIV,2200 BERGQUIST DR,LACKLAND AFB,TX 78236, USA. RI Hendrix, Craig/G-4182-2014 OI Hendrix, Craig/0000-0002-5696-8665 NR 24 TC 54 Z9 58 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD FEB 3 PY 1993 VL 269 IS 5 BP 622 EP 626 DI 10.1001/jama.269.5.622 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA KJ444 UT WOS:A1993KJ44400030 PM 8093628 ER PT J AU SHALEV, A HERMESH, H ROTHBERG, J MUNITZ, H AF SHALEV, A HERMESH, H ROTHBERG, J MUNITZ, H TI POOR NEUROLEPTIC RESPONSE IN ACUTELY EXACERBATED SCHIZOPHRENIC-PATIENTS SO ACTA PSYCHIATRICA SCANDINAVICA LA English DT Article DE SCHIZOPHRENIA; NEUROLEPTIC DRUG; TREATMENT RESISTANCE ID DRUGS AB Poor neuroleptic response is a major unresolved clinical problem. Precise data concerning the frequency of poor neuroleptic response are not available. The implementation of treatment modalities that are specifically recommended for non-responders (such as clozapine) increases the desirability of such data. This study evaluated the proportion of acutely exacerbated schizophrenics who remained unimproved by consecutive administration of haloperidol, chlorpromazine and perphenazine, in randomly determined order. The overall improvement rate was 95%. The frequency of good responses to the first, second and third drug were 67%, 55%, and 67% respectively. Differences in receptor affinity profile might explain the added beneficial effect of a second or third drug. C1 GEHAH PSYCHIAT HOSP,PETAH TIQWA,ISRAEL. TEL AVIV UNIV,SACKLER SCH MED,TEL AVIV,ISRAEL. WALTER REED ARMY INST RES,DEPT MIL PSYCHIAT,WASHINGTON,DC 20307. RP SHALEV, A (reprint author), HADASSAH UNIV HOSP,DEPT PSYCHIAT,POB 12000,IL-91120 JERUSALEM,ISRAEL. NR 28 TC 35 Z9 35 U1 2 U2 3 PU MUNKSGAARD INT PUBL LTD PI COPENHAGEN PA 35 NORRE SOGADE, PO BOX 2148, DK-1016 COPENHAGEN, DENMARK SN 0001-690X J9 ACTA PSYCHIAT SCAND JI Acta Psychiatr. Scand. PD FEB PY 1993 VL 87 IS 2 BP 86 EP 91 DI 10.1111/j.1600-0447.1993.tb03335.x PG 6 WC Psychiatry SC Psychiatry GA KN635 UT WOS:A1993KN63500002 PM 8095362 ER PT J AU WISWELL, TE MENDIOLA, J AF WISWELL, TE MENDIOLA, J TI RESPIRATORY-DISTRESS SYNDROME IN THE NEWBORN - INNOVATIVE THERAPIES SO AMERICAN FAMILY PHYSICIAN LA English DT Article AB Neonatal respiratory distress syndrome affects 60,000 to 70,000 infants each year in the United States. Although the mortality rate has decreased dramatically over the past 30 years, many infants die or have sequelae from the syndrome. Three innovative techniques are now playing a role in Improving the course of neonates with respiratory distress syndrome: surfactant replacement therapy, high-frequency ventilation and extracorporeal membrane oxygenation. Surfactant therapy should be considered the standard of care for infants with respiratory distress syndrome who require mechanical ventilation. Further investigation is needed to define the precise roles of high-frequency ventilation and extracorporeal membrane oxygenation in the management of neonates with respiratory distress syndrome. RP WISWELL, TE (reprint author), WALTER REED ARMY MED CTR,WASHINGTON,DC 20307, USA. NR 0 TC 5 Z9 5 U1 0 U2 0 PU AMER ACAD FAMILY PHYSICIANS PI KANSAS CITY PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 SN 0002-838X J9 AM FAM PHYSICIAN JI Am. Fam. Physician PD FEB 1 PY 1993 VL 47 IS 2 BP 407 EP 414 PG 8 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA KL872 UT WOS:A1993KL87200012 PM 8430594 ER PT J AU THOMAS, WJ BRUNO, P HOLTZMULLER, K AF THOMAS, WJ BRUNO, P HOLTZMULLER, K TI HEPATITIS-A VIRUS ANICTERIC ENCEPHALITIS COEXISTENT WITH HEPATITIS-C VIRUS-INFECTION SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Note ID IMMUNOGLOBULIN-M; VASCULITIS AB A 34-yr-old male presented with acute encephalitis. The encephalitis was due to an anicteric hepatitis A virus infection superimposed upon coexistent hepatitis C virus infection. Neurologic syndromes due to hepatitis A virus infection have all been associated with jaundice. Neurologic complications of hepatitis C virus infections have not been described. Identification of hepatitis A virus as an etiology of viral encephalitis can reduce the need for extensive costly evaluations, and unnecessary empiric antibiotics. Further clinical experience will determine if hepatitis C virus produces neurologic manifestations. RP THOMAS, WJ (reprint author), TRIPLER ARMY MED CTR,DEPT MED,HONOLULU,HI 96859, USA. NR 10 TC 12 Z9 12 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD FEB PY 1993 VL 88 IS 2 BP 279 EP 281 PG 3 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA KL615 UT WOS:A1993KL61500024 PM 8424434 ER PT J AU BABCOCK, J HARTMAN, K PEDERSEN, A MURPHY, M ALVING, B AF BABCOCK, J HARTMAN, K PEDERSEN, A MURPHY, M ALVING, B TI RODENTICIDE-INDUCED COAGULOPATHY IN A YOUNG-CHILD - A CASE OF MUNCHAUSEN-SYNDROME BY PROXY SO AMERICAN JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY LA English DT Article DE SUPERWARFARIN; BRODIFACOUM; INGESTIONS; RAT POISON ID PROLONGED ANTICOAGULATION; BRODIFACOUM; INGESTION; WARFARIN AB Purpose: To present the diagnosis and management of superwarfarin ingestion, a cause of serious and prolonged coagulopathy. Methods: Specific identification of the anticoagulant was made by high-pressure liquid chromatography. Results: A 24 month-old child developed bruises and a prolonged prothrombin time (PT) and activated partial thromboplastin time (aPTT) after receiving multiple doses of brodifacoum, a superwarfarin rodenticide. The coagulopathy was treated successfully with large doses of parenteral and oral vitamin K1; fresh frozen plasma was administered as a precautionary measure on two occasions. After the first 10 days of the child's hospitalization, the mother was identified as the source of brodifacoum, exemplifying the behavior described as Munchausen syndrome by proxy. Oral vitamin K1 was initiated and continued in an outpatient setting with tapering doses over nine months, using the PT as a guide for therapy. Conclusions: This report emphasizes the necessity of recognizing rodenticide poisoning and investigating its source. Frequent monitoring of the PT is essential to prevent hemorrhagic complications due to repeat exposure, inadequate vitamin K1 therapy, or noncompliance. C1 WALTER REED ARMY INST RES,DEPT HEMATOL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT PEDIAT,WASHINGTON,DC 20307. UNIV MINNESOTA,COLL VET MED,DEPT VET DIAGNOST MED,MINNEAPOLIS,MN 55455. NR 20 TC 29 Z9 30 U1 0 U2 1 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0192-8562 J9 AM J PEDIAT HEMATOL PD FEB PY 1993 VL 15 IS 1 BP 126 EP 130 PG 5 WC Oncology; Hematology; Pediatrics SC Oncology; Hematology; Pediatrics GA KJ339 UT WOS:A1993KJ33900021 PM 8447555 ER PT J AU KURANE, I INNIS, BL NIMMANNITYA, S NISALAK, A MEAGER, A ENNIS, FA AF KURANE, I INNIS, BL NIMMANNITYA, S NISALAK, A MEAGER, A ENNIS, FA TI HIGH-LEVELS OF INTERFERON-ALPHA IN THE SERA OF CHILDREN WITH DENGUE VIRUS-INFECTION SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID JAPANESE ENCEPHALITIS; LYMPHOCYTES; ANTIBODY; CYTOTOXICITY; MONOCYTES; MICE AB We measured the levels of interferon alpha (IFNalpha) in the sera of Thai children hospitalized with dengue hemorrhagic fever (DHF) or dengue fever (DF) to examine the role of IFNalpha in dengue virus infections of humans. The percentage of patients who had detectable levels of IFNalpha (greater-than-or-equal-to 3 U/ml) was higher in patients with DHF (80%, P < 0.001) and in patients with DF (60%, P < 0.001) than in healthy Thai children (7%). The levels of IFNalpha were higher in patients with DHF and in patients with DF on the first few days after the onset of fever than in healthy Thai children. The average levels of IFNalpha in patients with DHF were high two days before defervescence, decreasing gradually until the day of defervescence. There was a subset of patients with DHF who had increasing levels of IFNalpha after defervescence. However, the levels of IFNalpha in patients with DF were not high after fever subsided. The levels of IFNalpha were not different among children with DHF grades 1, 2 and 3. Among patients with DHF, T lymphocytes were activated to a higher degree in high IFNalpha producers than in low IFNalpha producers. These results indicate that similarly high levels of IFNalpha are produced in vivo during the acute stages of DHF and DF, and that high levels of IFNalpha remain after fever subsides in some patients with DHF, but not in patients with DF. C1 ARMED FORCES RES INST MED SCI,DEPT VIROL,BANGKOK 10400,THAILAND. CHILDRENS HOSP,BANGKOK 10400,THAILAND. NATL INST BIOL STAND & CONTROLS,DIV IMMUNOBIOL,HERTFORD EN6 3QG,HERTS,ENGLAND. RP KURANE, I (reprint author), UNIV MASSACHUSETTS,MED CTR,DEPT MED,DIV INFECT DIS & IMMUNOL,55 LAKE AVE N,WORCESTER,MA 01655, USA. FU NIAID NIH HHS [R01-AI-30624]; PHS HHS [T32-A-107272] NR 18 TC 71 Z9 75 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD FEB PY 1993 VL 48 IS 2 BP 222 EP 229 PG 8 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA KU121 UT WOS:A1993KU12100013 PM 8447527 ER PT J AU SNYDER, AP HARDEN, CS BRITTAIN, AH KIM, MG ARNOLD, NS MEUZELAAR, HLC AF SNYDER, AP HARDEN, CS BRITTAIN, AH KIM, MG ARNOLD, NS MEUZELAAR, HLC TI PORTABLE HAND-HELD GAS-CHROMATOGRAPHY ION MOBILITY SPECTROMETRY DEVICE SO ANALYTICAL CHEMISTRY LA English DT Article ID IONIZATION MASS-SPECTROMETRY; CHEMICAL WARFARE AGENTS; REAL-TIME DETECTION; PLASMA CHROMATOGRAPHY; WASTE-WATER; AIR; IDENTIFICATION AB The concept of a portable gas chromatography/ion mobility spectrometry (GC/IMS) device is introduced. The potential of the GC/IMS unit is investigated for the separation and characterization of vapor mixtures of various chemical classes. Parameters such as internal cell pressure, GC column flow rate, and column temperature were varied to determine the effects on speed and resolution for separating and characterizing mixtures. It was generally found that by reducing both the internal IMS cell pressure and the isothermal GC column temperature, the peak widths, retention times, and peak overlap could be varied for different classes of analytes. The GC/IMS system shows versatility in the various compound classes that can conveniently be analyzed by a hand-portable version. Mixtures included phosphonates, phosphates, alkyl ketones, and chlorophenols with total separation times in the 7-s to 2-min time range. Positive or negative ion polarities in IMS were used depending upon the functional group. C1 GRASEBY ION LTD,WATFORD,HERTS,ENGLAND. UNIV UTAH,SALT LAKE CITY,UT 84112. RP SNYDER, AP (reprint author), USA,EDGEWOOD RES DEV & ENGN CTR,ABERDEEN PROVING GROUND,MD 21010, USA. NR 46 TC 60 Z9 60 U1 1 U2 18 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0003-2700 J9 ANAL CHEM JI Anal. Chem. PD FEB 1 PY 1993 VL 65 IS 3 BP 299 EP 306 DI 10.1021/ac00051a019 PG 8 WC Chemistry, Analytical SC Chemistry GA KK450 UT WOS:A1993KK45000019 ER PT J AU SHORT, LH PETERSON, RE MONGAN, PD AF SHORT, LH PETERSON, RE MONGAN, PD TI PHYSIOLOGICAL AND ANESTHETIC ALTERATIONS ON SPINAL-SCIATIC EVOKED-RESPONSES IN SWINE SO ANESTHESIA AND ANALGESIA LA English DT Article ID CORD BLOOD-FLOW; NITROUS-OXIDE; ELECTRICAL-STIMULATION; POTENTIALS; ISOFLURANE; SURGERY; ENFLURANE; DEFICITS; HUMANS AB Spinal-sciatic evoked responses (ScER) have been used successfully to monitor the integrity of the anterior spinal cord during spinal surgery. To evaluate the effects of hypercarbia, hypocarbia, induced hypotension, and hypothermia on the ScER, ten swine anesthetized with ketamine were subjected to varying levels of PaCO2, hypothermia, and induced hypotension. During variation of one physiologic variable, the other variables were closely regulated. There were no significant changes associated with variations in PaCO2. Decreasing temperature provided a consistent increase in latency (r = -0.78, P < 0.001) with no significant alteration in amplitude. Graded hypotension caused little increase in latency (3.2% at 30 mm Hg). The amplitude decrease averaged 23% at 60 mm Hg with a maximal decrease of 50% at 30 mm Hg. To study inhaled anesthetics, 21 swine anesthetized with ketamine were subjected to nitrous oxide (50% and 70%). After termination of the nitrous oxide, one of the potent inhaled anesthetics (n = 7 each) was administered in 0.25 minimum alveolar concentration (MAC) increments. Nitrous oxide caused a significant decrease in amplitude (average 43% and 61 % at 50% and 70%) with minimal changes in latency. There was a dose-dependent decrease in amplitude and increase in latency with all inhaled anesthetics. The ScER disappeared at 1.0 MAC with all anesthetics. There were no differences between effects of equipotent concentrations of inhaled anesthetics. These findings may be helpful in the interpretation of the ScER response during anesthesia and surgery. C1 BROOKE ARMY MED CTR,DEPT SURG,ANESTHESIA & OPERAT SERV,FT SAM HOUSTON,TX 78234. NR 24 TC 3 Z9 3 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0003-2999 J9 ANESTH ANALG JI Anesth. Analg. PD FEB PY 1993 VL 76 IS 2 BP 259 EP 265 PG 7 WC Anesthesiology SC Anesthesiology GA KY037 UT WOS:A1993KY03700010 PM 8424501 ER PT J AU CALKIN, M KIM, KC PRICE, C PRIEST, J AF CALKIN, M KIM, KC PRICE, C PRIEST, J TI RISK-FACTORS FOR NEGATIVE-PRESSURE PULMONARY-EDEMA SO ANESTHESIA AND ANALGESIA LA English DT Meeting Abstract C1 TRIPLER ARMY MED CTR,HONOLULU,HI 96859. NR 1 TC 0 Z9 1 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0003-2999 J9 ANESTH ANALG JI Anesth. Analg. PD FEB PY 1993 VL 76 IS 2 SU S BP S32 EP S32 PG 1 WC Anesthesiology SC Anesthesiology GA KY039 UT WOS:A1993KY03900032 ER PT J AU KARAN, SM LOJESKI, EW BOEDEKER, BH FREAS, W HAYNES, DH MULDOON, SM AF KARAN, SM LOJESKI, EW BOEDEKER, BH FREAS, W HAYNES, DH MULDOON, SM TI MICROENCAPSULATED DANTROLENE VS DANTROLENE - DOSE-RESPONSE TO MUSCULAR TWITCH IN RATS SO ANESTHESIA AND ANALGESIA LA English DT Meeting Abstract C1 UNIFORMED SERV UNIV HLTH SCI,DEPT ANESTHESIOL,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 2 TC 1 Z9 1 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0003-2999 J9 ANESTH ANALG JI Anesth. Analg. PD FEB PY 1993 VL 76 IS 2 SU S BP S181 EP S181 PG 1 WC Anesthesiology SC Anesthesiology GA KY039 UT WOS:A1993KY03900180 ER PT J AU MONGAN, P WILLIAMS, D AF MONGAN, P WILLIAMS, D TI SPINAL-SCIATIC EVOKED-RESPONSES ARE PREDICTIVE OF NEUROLOGIC INJURY IN SWINE SO ANESTHESIA AND ANALGESIA LA English DT Meeting Abstract C1 BROOKE ARMY MED CTR,ANESTHESIA SERV,FT SAM HOUSTON,TX 78234. BROOKE ARMY MED CTR,CLIN INVEST SERV,FT SAM HOUSTON,TX 78234. NR 2 TC 1 Z9 1 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0003-2999 J9 ANESTH ANALG JI Anesth. Analg. PD FEB PY 1993 VL 76 IS 2 SU S BP S273 EP S273 PG 1 WC Anesthesiology SC Anesthesiology GA KY039 UT WOS:A1993KY03900271 ER PT J AU MONGAN, PD DUCEY, JP AF MONGAN, PD DUCEY, JP TI THE EFFECTS OF ISOFLURANE ON THE SPINAL MOTOR EVOKED-POTENTIAL SO ANESTHESIA AND ANALGESIA LA English DT Meeting Abstract C1 BROOKE ARMY MED CTR,ANESTHESIA SERV,FT SAM HOUSTON,TX 78234. BROOKE ARMY MED CTR,ORTHOPED SERV,FT SAM HOUSTON,TX 78234. NR 2 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0003-2999 J9 ANESTH ANALG JI Anesth. Analg. PD FEB PY 1993 VL 76 IS 2 SU S BP S272 EP S272 PG 1 WC Anesthesiology SC Anesthesiology GA KY039 UT WOS:A1993KY03900270 ER PT J AU MONGAN, PD DUCEY, JP AF MONGAN, PD DUCEY, JP TI THE EFFECT OF ISOFLURANE ON THE SPINAL-SCIATIC EVOKED-RESPONSE SO ANESTHESIA AND ANALGESIA LA English DT Meeting Abstract C1 BROOKE ARMY MED CTR,ANESTHESIA SERV,FT SAM HOUSTON,TX 78234. BROOKE ARMY MED CTR,ORTHOPED SERV,FT SAM HOUSTON,TX 78234. NR 2 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0003-2999 J9 ANESTH ANALG JI Anesth. Analg. PD FEB PY 1993 VL 76 IS 2 SU S BP S271 EP S271 PG 1 WC Anesthesiology SC Anesthesiology GA KY039 UT WOS:A1993KY03900269 ER PT J AU SCHIFFER, DH MONGAN, PD HOSKING, M AF SCHIFFER, DH MONGAN, PD HOSKING, M TI COMPARING 2 METHODS OF POST CARDIOPULMONARY BYPASS THROMBOELASTOGRAPHIC ANALYSIS SO ANESTHESIA AND ANALGESIA LA English DT Meeting Abstract C1 BROOKE ARMY MED CTR,ANESTHESIA SERV,FT SAM HOUSTON,TX 78234. NR 2 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0003-2999 J9 ANESTH ANALG JI Anesth. Analg. PD FEB PY 1993 VL 76 IS 2 SU S BP S376 EP S376 PG 1 WC Anesthesiology SC Anesthesiology GA KY039 UT WOS:A1993KY03900374 ER PT J AU PREWITT, KC ZEN, BJ WORTHAM, DC PEARSON, C AF PREWITT, KC ZEN, BJ WORTHAM, DC PEARSON, C TI INCREASED RISK OF CORONARY-ARTERY DISSECTION DURING CORONARY ANGIOGRAPHY WITH 6F CATHETERS SO ANGIOLOGY LA English DT Article ID CARDIAC-CATHETERIZATION; FRENCH CATHETERS; ARTERIOGRAPHY; COMPLICATIONS; 5F AB The use of smaller sized catheters for coronary angiography (CA) is increasing, but little is known about the safety of CA with 6F catheters. The authors reviewed all cases of CA in which 6F and 8F catheters were used in adult patients between 1988 and June, 1990. There were 597 patients in the 6F group and 2,409 patients in the 8F group. Cases of CA with 6F catheters were more likely to be elective (95% vs 87%), to have no coronary disease (35% vs 24%), and to be performed by nonfirst-year fellows (70% vs 54%) when compared with CA with 8F catheters. There were 5 cases of coronary artery dissection. The incidence of dissections was significantly higher (p=.007) in the 6F group (0.67%) than in the 8F group (0.04%). The incidence of dissections was highest for first-year fellows using 6F catheters (1.7%), which was significantly higher (p=.008) than for first-year fellows using 8F catheters. The incidence of major vascular complications tended to be lower (p=.068) in the 6F group (0.17%) than in the 8F group (0.95%). In summary, CA with 6F catheters is associated with an increased risk of coronary artery dissection, particularly with less experienced operators, but tends to be associated with a lower risk of major vascular complications. RP PREWITT, KC (reprint author), WALTER REED ARMY MED CTR,CARDIOL SERV,WASHINGTON,DC 20307, USA. NR 19 TC 6 Z9 6 U1 0 U2 1 PU WESTMINSTER PUBL INC PI GLEN HEAD PA 708 GLEN COVE AVE, GLEN HEAD, NY 11545 SN 0003-3197 J9 ANGIOLOGY JI Angiology PD FEB PY 1993 VL 44 IS 2 BP 107 EP 113 DI 10.1177/000331979304400204 PG 7 WC Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA KK919 UT WOS:A1993KK91900004 PM 8434803 ER PT J AU RINALDI, DA LIPPMAN, SM BURRIS, HA CHOU, C VONHOFF, DD HONG, WK AF RINALDI, DA LIPPMAN, SM BURRIS, HA CHOU, C VONHOFF, DD HONG, WK TI PHASE-II STUDY OF 13-CIS-RETINOIC ACID AND INTERFERON-ALPHA-2A IN PATIENTS WITH ADVANCED SQUAMOUS-CELL LUNG-CANCER SO ANTI-CANCER DRUGS LA English DT Article DE INTERFERON; LUNG CANCER; RETINOIC ACID; SQUAMOUS CELL ID THERAPEUTIC ANTICANCER AGENTS; RECOMBINANT ALPHA-INTERFERON; RANDOMIZED TRIAL; RETINOIC ACID; CARCINOMA; ISOTRETINOIN; LEUKEMIA; CHEMOTHERAPY; MULTICENTER; PREVENTION AB The combination of interferon (IFN)-alpha2a and 13-cis-retinoic acid (13-cRA) has demonstrated significant antitumor activity in patients with advanced squamous cell cancer of the skin and cervix. We performed a prospective phase II trial of this combination in patients with locally advanced or metastatic squamous cell lung cancer. Twenty-one patients were enrolled on the study. All patients were evaluable for toxicity and 17 were evaluable for response, four with locally advanced and 13 with metastatic disease. One partial response was obtained in a patient with locally advanced disease. Toxicity consisted mainly of constitutional side effects (fatigue, anorexia), which resulted in eight patients coming off-study. The combination of IFN-alpha2a and 13-cRA is unlikely to exhibit significant clinical activity in patients with metastatic squamous cell lung cancer, but activity in patients with locally advanced disease has not been excluded. C1 UNIV TEXAS,MD ANDERSON CANC CTR,HOUSTON,TX 77030. BROOKE ARMY MED CTR,SAN ANTONIO,TX 78234. CANC THERAPY & RES CTR,SAN ANTONIO,TX 78284. NR 40 TC 31 Z9 31 U1 0 U2 0 PU RAPID SCIENCE PUBLISHERS PI LONDON PA 2-6 BOUNDARY ROW, LONDON, ENGLAND SE1 8NH SN 0959-4973 J9 ANTI-CANCER DRUG JI Anti-Cancer Drugs PD FEB PY 1993 VL 4 IS 1 BP 33 EP 36 DI 10.1097/00001813-199302000-00004 PG 4 WC Oncology; Pharmacology & Pharmacy SC Oncology; Pharmacology & Pharmacy GA KP525 UT WOS:A1993KP52500004 PM 8457712 ER PT J AU ISLAM, MS HASAN, MK MIAH, MA SUR, GC FELSENSTEIN, A VENKATESAN, M SACK, RB ALBERT, MJ AF ISLAM, MS HASAN, MK MIAH, MA SUR, GC FELSENSTEIN, A VENKATESAN, M SACK, RB ALBERT, MJ TI USE OF THE POLYMERASE CHAIN-REACTION AND FLUORESCENT-ANTIBODY METHODS FOR DETECTING VIABLE BUT NONCULTURABLE SHIGELLA-DYSENTERIAE TYPE-1 IN LABORATORY MICROCOSMS SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY LA English DT Article ID ENTEROINVASIVE ESCHERICHIA-COLI; INVASION PLASMID; VIBRIO-CHOLERAE; CAMPYLOBACTER-JEJUNI; DNA PROBES; FLEXNERI; ENVIRONMENT; BACTERIA; GENE; IPAH AB Epidemiological studies of shigellosis in Bangladesh have demonstrated that surface-water sources can act as foci of infection. Studies of laboratory microcosms have shown that shigellae become nonculturable but remain viable when exposed to environmental samples of water. The present study was carried out to detect viable but nonculturable Shigella dysenteriae 1 from laboratory microcosms by the polymerase chain reaction and the fluorescent-antibody techniques. S. dysenteriae 1 was inoculated into laboratory microcosms consisting of water samples collected from ponds, lakes, rivers, and drains in Bangladesh. The survival of S. dysenteriae in microcosms was assessed by viable counting on MacConkey agar. After 2 to 3 weeks, S. dysenteriae 1 became nonculturable but remained viable. After 6 weeks, this nonculturable but viable S. dysenteriae 1 was detected by both the polymerase chain reaction and the fluorescent-antibody methods. The viable but nonculturable state of S. dysenteriae 1 demonstrated in this study may be important for understanding the epidemiology of shigellosis. C1 WALTER REED ARMY INST RES,WASHINGTON,DC 20307. RP ISLAM, MS (reprint author), INT CTR DIARRHOEAL DIS RES,POB 128,DHAKA 1000,BANGLADESH. NR 36 TC 60 Z9 63 U1 1 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0099-2240 J9 APPL ENVIRON MICROB JI Appl. Environ. Microbiol. PD FEB PY 1993 VL 59 IS 2 BP 536 EP 540 PG 5 WC Biotechnology & Applied Microbiology; Microbiology SC Biotechnology & Applied Microbiology; Microbiology GA KK916 UT WOS:A1993KK91600028 PM 8434918 ER PT J AU BISWAS, R FLAHERTY, JE ARNEY, DC AF BISWAS, R FLAHERTY, JE ARNEY, DC TI AN ADAPTIVE MESH-MOVING AND REFINEMENT PROCEDURE FOR ONE-DIMENSIONAL CONSERVATION-LAWS SO APPLIED NUMERICAL MATHEMATICS LA English DT Article ID FINITE-ELEMENT METHOD; PARTIAL-DIFFERENTIAL EQUATIONS; LOCAL REFINEMENT; PARABOLIC-SYSTEMS AB We examine the performance of an adaptive mesh-moving and/or local mesh refinement procedure for the finite difference solution of one-dimensional hyperbolic systems of conservation laws. Adaptive motion of a base mesh is designed to isolate spatially distinct phenomena, and recursive local refinement of the time step and cells of the stationary or moving base mesh is performed in regions where a refinement indicator exceeds a prescribed tolerance. These adaptive procedures are incorporated into a computer code that includes a MacCormack finite difference scheme with Davis' artificial viscosity model and a discretization error estimate based on Richardson's extrapolation. Experiments are conducted on three problems in order to quantify the advantages of adaptive techniques relative to uniform mesh computations and the relative benefits of mesh moving and refinement. Key results indicate that local mesh refinement, with and without mesh moving, can provide reliable solutions at much lower computational cost than possible on uniform meshes; that mesh motion can be used to improve the results of uniform mesh solutions for a modest computational effort; that the cost of managing the tree data structure associated with refinement is small; and that a combination of mesh motion and refinement reliably produces solutions for the least cost per unit accuracy. C1 RENSSELAER POLYTECH INST,DEPT COMP SCI,TROY,NY 12180. US MIL ACAD,DEPT MATH,W POINT,NY 10996. RP BISWAS, R (reprint author), NASA,AMES RES CTR,RIACS,MAIL STOP TO45-1,MOFFETT FIELD,CA 94035, USA. NR 28 TC 8 Z9 8 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0168-9274 J9 APPL NUMER MATH JI Appl. Numer. Math. PD FEB PY 1993 VL 11 IS 4 BP 259 EP 282 DI 10.1016/0168-9274(93)90010-O PG 24 WC Mathematics, Applied SC Mathematics GA KJ231 UT WOS:A1993KJ23100001 ER PT J AU WARREN, WL TUTTLE, BA MCWHORTER, PJ RONG, FC POINDEXTER, EH AF WARREN, WL TUTTLE, BA MCWHORTER, PJ RONG, FC POINDEXTER, EH TI IDENTIFICATION OF PARAMAGNETIC PB-(+3) DEFECTS IN LEAD ZIRCONATE TITANATE CERAMICS SO APPLIED PHYSICS LETTERS LA English DT Article ID MEMORIES AB We report the first observation of positively charged Pb+3 defect centers in lead zirconate titanate (PZT) ceramics using electron paramagnetic resonance. The charged traps were optically generated using ultraviolet light energies roughly corresponding to the band gap of PZT (3.4 eV). The interpretation of the Pb-207(+3) hyperfine parameters indicates that the defect's unpaired electron is approximately 48% localized on the Pb nucleus. These observations may be of considerable importance since they prove that charged carriers created by optical excitation become trapped and form charged paramagnetic defects. C1 USA,RES LAB,FT MONMOUTH,NJ 07703. RP WARREN, WL (reprint author), SANDIA NATL LABS,ALBUQUERQUE,NM 87185, USA. NR 16 TC 16 Z9 16 U1 0 U2 1 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD FEB 1 PY 1993 VL 62 IS 5 BP 482 EP 484 DI 10.1063/1.108940 PG 3 WC Physics, Applied SC Physics GA KJ726 UT WOS:A1993KJ72600017 ER PT J AU BURGESS, LPA CASLER, JD KRYZER, TC AF BURGESS, LPA CASLER, JD KRYZER, TC TI WOUND TENSION IN RHYTIDECTOMY - EFFECTS OF SKIN-FLAP UNDERMINING AND SUPERFICIAL MUSCULOAPONEUROTIC SYSTEM SUSPENSION SO ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY LA English DT Article AB This study was conducted to determine the effects of skin-flap undermining and superficial musculoaponeurotic system (SMAS) suspension on wound-closing tension. Nine sides from five fresh-frozen cadavers were used, with closing tension measured at the two main anchor points, anteriorly (A) and posteriorly (P), with and without SMAS plication for minimal (MIN), intermediate (INT), and maximal (MAX) skin-flap undermining. Results indicated that closing tension was significantly decreased with SMAS plication, both A and P, for all three levels of skin undermining. The average decrease in dosing tension with SMAS plication was: A-MIN 191 & A-INT 95 & A-MAX 83 & P-MIN 235 g, P-INT 68 & and P-MAX 70 g (P<.001 for all). Considering the effect of skin-flap undermining alone, closing tension decreased with wider skin-flap undermining, both with and without SMAS plication. The tension-reducing effect of SMAS plication was decreased with wider skin-flap undermining. Regression analysis determined a second-order exponential curve relating dosing tension to skin excision. C1 WALTER REED ARMY MED CTR,OTOLARYNGOL HEAD & NECK SURG SERV,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. NR 8 TC 10 Z9 11 U1 0 U2 1 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0886-4470 J9 ARCH OTOLARYNGOL JI Arch. Otolaryngol. Head Neck Surg. PD FEB PY 1993 VL 119 IS 2 BP 173 EP 177 PG 5 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA KL173 UT WOS:A1993KL17300010 PM 8427680 ER PT J AU MURPHY, MR BLICK, DW DUNN, MA FANTON, JW HARTGRAVES, SL AF MURPHY, MR BLICK, DW DUNN, MA FANTON, JW HARTGRAVES, SL TI DIAZEPAM AS A TREATMENT FOR NERVE AGENT POISONING IN PRIMATES SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article ID SOMAN; PYRIDOSTIGMINE; THERAPY; PRETREATMENT; PATHOLOGY AB Diazepam is known to decrease organophosphate nerve agent-induced convulsions, neuropathology, and lethality in rhesus monkeys. We report that, when added to the previously fielded treatment regimen (pyridostigmine, atropine, and pralidoxime chloride), diazepam significantly protects the performance of rhesus monkeys trained in an equilibrium task, the Primate Equilibrium Platform (PEP), against deficits induced by the nerve-agent soman. If administered soon enough to minimize the occurrence of convulsions, diazepam should increase the probability of mission accomplishment and eventual complete recovery from nerve agent poisoning. Diazepam was fielded by the United States military services during Operations Desert Shield and Storm for the treatment of possible organophosphate toxicity. C1 ARMSTRONG LAB,SAN ANTONIO,TX. DIRECTED ENERGY DIV,ABERDEEN PROVING GROUND,MD. VET SCI DIV,SYST RES LABS,ABERDEEN PROVING GROUND,MD. USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010. NR 17 TC 20 Z9 20 U1 0 U2 1 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD FEB PY 1993 VL 64 IS 2 BP 110 EP 115 PG 6 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA KJ341 UT WOS:A1993KJ34100003 PM 8431183 ER PT J AU MAPOU, RL KAY, GG RUNDELL, JR TEMOSHOK, L AF MAPOU, RL KAY, GG RUNDELL, JR TEMOSHOK, L TI MEASURING PERFORMANCE DECREMENTS IN AVIATION PERSONNEL INFECTED WITH THE HUMAN-IMMUNODEFICIENCY-VIRUS SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article ID HIV-1 INFECTION; NEUROPSYCHOLOGICAL ASSESSMENT; HOMOSEXUAL MEN; AIDS AB There is controversy over whether cognitive impairment occurs in early human immunodeficiency virus (HIV) disease. When impairment is reported, findings are typically subclinical, affect only a minority, and their relationship to occupational functioning has not been established. Despite such findings, it has been recommended that HIV-seropositive pilots be disqualified from flying. This paper reviews research relevant to measuring performance decrements in HIV-infected aviators. Based upon current data, we conclude that although subtle neurobehavioral dysfunction may occur in some asymptomatic HIV-seropositive individuals, there is no research which has demonstrated associated decrements in aviation-related skills. Thus, it may be premature to recommend medical disqualification of all HIV-seropositive aviators. We propose, instead, that sensitive neurocognitive measures, incorporated into a comprehensive neurodiagnostic evaluation, could be used to evaluate asymptomatic HIV-seropositive aviators. Only those who are impaired on evaluation would be disqualified from flying. Concurrently, research investigating the relationship between abnormalities and aviation abilities would be conducted. C1 WALTER REED ARMY INST RES,WASHINGTON,DC 20307. GEORGETOWN UNIV,SCH MED,DEPT NEUROL,WASHINGTON,DC. RP MAPOU, RL (reprint author), HENRY M JACKSON FDN ADV MIL MED,MIL MED CONSORTIUM APPL RETROVIRAL RES,1 TAFT COURT,SUITE 250,ROCKVILLE,MD 20850, USA. NR 27 TC 11 Z9 11 U1 0 U2 1 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD FEB PY 1993 VL 64 IS 2 BP 158 EP 164 PG 7 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA KJ341 UT WOS:A1993KJ34100011 PM 8431191 ER PT J AU PILLALAMARRI, RS BARNETTE, BD BIRKMIRE, D KARSH, R AF PILLALAMARRI, RS BARNETTE, BD BIRKMIRE, D KARSH, R TI CLUSTER - A PROGRAM FOR THE IDENTIFICATION OF EYE-FIXATION-CLUSTER CHARACTERISTICS SO BEHAVIOR RESEARCH METHODS INSTRUMENTS & COMPUTERS LA English DT Article ID MOVEMENT AB Innovations in software for the analysis of eye movements have not kept pace with the development of hardware for collecting samples of eye position (Scinto & Barnette, 1986). Eye fixation and duration have been the primary measures for gleaning knowledge of subjects' performance while the subjects are engaged in cognitive visual tasks. The program Cluster was developed as a means of investigating the dynamics of target examination characteristics that do not lend themselves to traditional methods of eye-movement analysis. This tool has proved to be a valuable means of assessing visual activity at a micro level, in comparison with the gross measures of distribution of visual attention in various areas of the visual field. In this report, we describe the history surrounding the development of Cluster as an analytical tool, the source of input required for its execution, the mechanics of the execution as an interactive process, the replicability of raters' judgments, the program's products of visual displays and data file output, and the potential application of such a tool for analyzing visual activity. C1 USA,RES LAB,HUMAN RES & ENGN DIRECTORATE,ABERDEEN PROVING GROUND,MD 21005. NR 7 TC 9 Z9 9 U1 0 U2 0 PU PSYCHONOMIC SOC INC PI AUSTIN PA 1710 FORTVIEW RD, AUSTIN, TX 78704 SN 0743-3808 J9 BEHAV RES METH INSTR JI Behav. Res. Methods Instr. Comput. PD FEB PY 1993 VL 25 IS 1 BP 9 EP 15 DI 10.3758/BF03204444 PG 7 WC Psychology, Mathematical; Psychology, Experimental SC Psychology GA LE096 UT WOS:A1993LE09600002 ER PT J AU NARANG, SK KLEIN, TA PERERA, OP LIMA, JB TANG, AT AF NARANG, SK KLEIN, TA PERERA, OP LIMA, JB TANG, AT TI GENETIC-EVIDENCE FOR THE EXISTENCE OF CRYPTIC SPECIES IN THE ANOPHELES-ALBITARSIS COMPLEX IN BRAZIL - ALLOZYMES AND MITOCHONDRIAL-DNA RESTRICTION-FRAGMENT-LENGTH-POLYMORPHISMS SO BIOCHEMICAL GENETICS LA English DT Article ID CULICIDAE; DIPTERA; IDENTIFICATION; MOSQUITOS; KEY AB Allozyme and mitochondrial DNA (mtDNA) restriction studies were undertaken to determine the extent of genetic divergence among field populations of Anopheles albitarsis in Brazil. Two sympatric species, An. deaneorum and An. marajoara, were identified in collections from Costa Marques (CM), Rondonia. Genetic evidence includes (1) the presence of two types of individuals, each with diagnostic allelic clusters (for Had-1, Pgi-1, Pep-1, Mpi-1, and Idh-1), (2) a deficiency of heterozygotes, and (3) characteristic mtDNA haplotypes. In addition, two allopatric cryptic species of An. marajoara were identified, one from Iguape (An. marajoara form IG), Sao Paulo state, and the other from the Island of Marajo (An. marajoara form MA). Though form IG and form-MA resemble form CM in wing spot morphology, they differ from it in diagnostic allozymes and mtDNA haplotypes. An. marajoara form CM had a higher variability (mean heterozygosity, H = 0.22, and percentage of polymorphic loci, P = 66.7) than did form IG and form MA (H = 0.08 in both, and P = 25.0 and 33.3, respectively). Form MA and form IG are genetically more similar to each other than both are to form CM. Based on wing morphology, estimates of F statistics, and genetic similarities, we propose that An. albitarsis in Brazil is a species complex. It comprises at least two morphologically distinguishable species: (1) An. deaneorum (currently one taxon) and (2) the An. marajoara species complex, which further consists of at least three cryptic forms, marajoara form MA, marajoara form IG, and marajoara form CM. C1 WALTER REED ARMY INST RES,DEPT ENTOMOL,DIV COMMUNICABLE DIS & IMMUNOL,WASHINGTON,DC 20307. USDA ARS,MED & VET ENTOMOL LAB,GAINESVILLE,FL 32604. INST BIOL EXERCITO,BR-20911 RIO JANEIRO,BRAZIL. MINIST SAUDE,SUCAM,DIV MALARIA,CENT ENTOMOL LAB,BR-70058 BRASILIA,DF,BRAZIL. RP NARANG, SK (reprint author), USDA ARS,BIOSCI RES LAB,POB 5674,SO STN,FARGO,ND 58105, USA. NR 23 TC 39 Z9 39 U1 0 U2 2 PU PLENUM PUBL CORP PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 SN 0006-2928 J9 BIOCHEM GENET JI Biochem. Genet. PD FEB PY 1993 VL 31 IS 1-2 BP 97 EP 112 DI 10.1007/BF02399823 PG 16 WC Biochemistry & Molecular Biology; Genetics & Heredity SC Biochemistry & Molecular Biology; Genetics & Heredity GA KV631 UT WOS:A1993KV63100009 PM 8097085 ER PT J AU NAUSS, JL OLSON, WK AF NAUSS, JL OLSON, WK TI THE DISTINGUISHING CHARACTERISTICS BETWEEN A-DNA AND B-DNA HELICES SO BIOPHYSICAL JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,DEPT GASTROENTEROL,WASHINGTON,DC 20307. RUTGERS STATE UNIV,DEPT CHEM,PISCATAWAY,NJ 08855. NR 0 TC 0 Z9 0 U1 0 U2 0 PU BIOPHYSICAL SOCIETY PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0006-3495 J9 BIOPHYS J JI Biophys. J. PD FEB PY 1993 VL 64 IS 2 BP A279 EP A279 PN 2 PG 1 WC Biophysics SC Biophysics GA KP517 UT WOS:A1993KP51701596 ER PT J AU JOHNSON, ED AF JOHNSON, ED TI COMPARISON OF A FORMAMIDE-BASED STRIPPING METHOD WITH A HOT SDS METHOD SO BIOTECHNIQUES LA English DT Note RP JOHNSON, ED (reprint author), USA,CRIMINAL INVESTIGAT LAB,CONTINENTAL UNITED STATES BLDG 213-B,FT GILLEM,GA 30050, USA. NR 5 TC 5 Z9 5 U1 0 U2 0 PU EATON PUBLISHING CO PI NATICK PA 154 E. CENTRAL ST, NATICK, MA 01760 SN 0736-6205 J9 BIOTECHNIQUES JI Biotechniques PD FEB PY 1993 VL 14 IS 2 BP 162 EP 163 PG 2 WC Biochemical Research Methods; Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA KL409 UT WOS:A1993KL40900001 PM 8431272 ER PT J AU MOUL, JW AF MOUL, JW TI RETROPERITONEAL LYMPHADENECTOMY SO CANADIAN JOURNAL OF SURGERY LA English DT Letter C1 UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. RP MOUL, JW (reprint author), WALTER REED ARMY MED CTR,WASHINGTON,DC 20307, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU CANADIAN MEDICAL ASSOCIATION PI OTTAWA PA 1867 ALTA VISTA DR, OTTAWA ON K1G 3Y6, CANADA SN 0008-428X J9 CAN J SURG JI Can. J. Surg. PD FEB PY 1993 VL 36 IS 1 BP 16 EP 16 PG 1 WC Surgery SC Surgery GA KN604 UT WOS:A1993KN60400007 PM 8443712 ER PT J AU MCLEOD, DG AF MCLEOD, DG TI ANTIANDROGENIC DRUGS SO CANCER LA English DT Article; Proceedings Paper CT 1ST NATIONAL CONF ON PROSTATE CANCER CY FEB 13-15, 1992 CL SAN FRANCISCO, CA SP AMER CANC SOC, AMER ACAD FAMILY PHYSICIANS, AMER COLL RADIOL, AMER COLL SURGEONS, COMMISS CANC, AMER UROL ASSOC, NATL ASSOC ONCOL SOCIAL WORKERS, NATL ASSOC SOCIAL WORKERS, ONCOL NURSING SOC, SOC SURG ONCOL DE ANTIANDROGENS; PROSTATE CANCER; METASTATIC AND EARLY; MAXIMAL ANDROGEN DEPRIVATION ID ADVANCED PROSTATIC-CANCER; MEGESTROL-ACETATE; CYPROTERONE-ACETATE; UNTREATED PATIENTS; CONTROLLED TRIAL; CARCINOMA; DIETHYLSTILBESTROL; CASTRATION; NILUTAMIDE; FLUTAMIDE AB Background. Prostate cancer is the most frequent cancer diagnosed in American men today. Currently, about half of all patients with newly diagnosed prostate cancer present with metastatic diseases. Methods. Antiandrogenic drugs, or more appropriately androgen-receptor antagonists, represent a group of compounds that currently have played a limited role in the treatment of metastatic prostate cancer. Their method of action is primarily one of blocking androgens at their receptor sites in target tissues. They generally are classified as steroidal or nonsteroidal compounds. Cyproterone acetate and megestrol acetate are synthetic steroidal antiandrogenic drugs that, not only compete with testosterone and dihydrotestosterone for androgen receptors, but also have progestational activity and reduce pituitary luteinizing hormone and subsequently plasma testosterone. Nonsteroidal antiandrogenic agents (flutamide, Casodex [ICI Pharmaceuticals, England], and nilutamide) block cellular binding of androgens only, and there is no reduction of testosterone levels. Results. Antiandrogenics have been used in numerous trials both in Europe and the United States. This group of compounds have been used as monotherapy and in combination therapy, ie, with orchiectomy or with LHRH agonists. Conclusions. Currently, antiandrogens are used primarily in conjunction with conventional medical or surgical castration to achieve maximal androgen deprivation; however, ongoing clinical studies are comparing these compounds alone against standard hormonal therapy. It seems probable that antiandrogens will play an expanding role in the treatment of metastatic prostate cancer as well as having a role in the treatment of prostate cancer. C1 UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. RP MCLEOD, DG (reprint author), WALTER REED ARMY MED CTR,UROL SERV,WASHINGTON,DC 20307, USA. NR 18 TC 57 Z9 58 U1 1 U2 5 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0008-543X J9 CANCER JI Cancer PD FEB 1 PY 1993 VL 71 IS 3 SU S BP 1046 EP 1049 DI 10.1002/1097-0142(19930201)71:3+<1046::AID-CNCR2820711424>3.0.CO;2-M PG 4 WC Oncology SC Oncology GA KM674 UT WOS:A1993KM67400023 PM 8428326 ER PT J AU CARDELLO, AV AF CARDELLO, AV TI WHAT DO CONSUMERS EXPECT FROM LOW-CAL, LOW-FAT, LITE FOODS SO CEREAL FOODS WORLD LA English DT Article RP CARDELLO, AV (reprint author), USA,NATICK RES DEV & ENGN CTR,DIV BEHAV SCI,NATICK,MA 01760, USA. NR 0 TC 7 Z9 7 U1 1 U2 2 PU AMER ASSOC CEREAL CHEMISTS PI ST PAUL PA 3340 PILOT KNOB RD, ST PAUL, MN 55121-2097 SN 0146-6283 J9 CEREAL FOOD WORLD JI Cereal Foods World PD FEB PY 1993 VL 38 IS 2 BP 96 EP & PG 0 WC Food Science & Technology SC Food Science & Technology GA KY122 UT WOS:A1993KY12200008 ER PT J AU DILLARD, TA ROSENBERG, AP BERG, BW AF DILLARD, TA ROSENBERG, AP BERG, BW TI HYPOXEMIA DURING ALTITUDE EXPOSURE - A METAANALYSIS OF CHRONIC OBSTRUCTIVE PULMONARY-DISEASE SO CHEST LA English DT Article ID AIR-TRAVEL AB A previous study identified spirometric testing as a useful adjunct for estimating PaO2 during altitude exposure in patients with chronic obstructive pulmonary disease (COPD). We sought to examine the validity of this finding by quantitative analysis of recent published reports. We analyzed acute hypoxic exposures from five prior studies involving 71 patients. Across all studies, the change in arterial oxygen tension per unit change in inspired oxygen partial pressure (linear slope, dPaO2/dPIO2) correlated with the preexposure forced expiratory volume in 1 s (FEV1, p<0.01). The correlation with FEV1 held for values weighted or unweighted by sample size, with rotating deletion of each study from analysis one at a time, and with semilog slope as the dependent variable. A formula derived from the semilog slope relationship with FEV1 gave accurate description of the mean hypoxic response in each prior study and individual responses from one study (n = 18): ln (PaO2alt/PaO2g) = k(n) . (PIO2alt - PIO2g). We found that FEV1 modulated the values of k(n) in this study. We conclude, based on analysis of prior studies, that preexposure arterial oxygen tension and FEV1 both influence the prediction of PaO2 during hypoxic exposures in patients with COPD. C1 WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. JOHNS HOPKINS UNIV,APPL PHYS LAB,LAUREL,MD 20707. RP DILLARD, TA (reprint author), WALTER REED ARMY MED CTR,DEPT MED,BLDG 2,RM 6316,WASHINGTON,DC 20307, USA. NR 11 TC 35 Z9 36 U1 0 U2 1 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 SN 0012-3692 J9 CHEST JI Chest PD FEB PY 1993 VL 103 IS 2 BP 422 EP 425 DI 10.1378/chest.103.2.422 PG 4 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA KL712 UT WOS:A1993KL71200023 PM 8432131 ER PT J AU MELTZER, MS KORNBLUTH, RS HANSEN, B DHAWAN, S GENDELMAN, HE AF MELTZER, MS KORNBLUTH, RS HANSEN, B DHAWAN, S GENDELMAN, HE TI HIV-INFECTION OF THE LUNG - ROLE OF VIRUS-INFECTED MACROPHAGES IN THE PATHOPHYSIOLOGY OF PULMONARY-DISEASE SO CHEST LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; NECROSIS-FACTOR-ALPHA; LYMPHOCYTES-T; MONONUCLEAR PHAGOCYTES; PERIPHERAL-BLOOD; ALVEOLAR MACROPHAGES; INTERFERON-ALPHA; HUMAN-MONOCYTES; CELL TROPISM; AIDS VIRUS C1 UNIV CALIF SAN DIEGO,DEPT MED,LA JOLLA,CA 92093. VET ADM MED CTR,SAN DIEGO,CA 92161. RP MELTZER, MS (reprint author), WALTER REED ARMY INST RES,DEPT CELLULAR IMMUNOL,WASHINGTON,DC 20307, USA. FU NHLBI NIH HHS [HL-43523]; NIAID NIH HHS [AI-25316] NR 58 TC 15 Z9 15 U1 0 U2 0 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 SN 0012-3692 J9 CHEST JI Chest PD FEB PY 1993 VL 103 IS 2 SU S BP S103 EP S108 PG 6 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA KM537 UT WOS:A1993KM53700014 PM 8428524 ER PT J AU WELLS, C BERTSCH, W PERICH, M AF WELLS, C BERTSCH, W PERICH, M TI INSECTICIDAL VOLATILES FROM THE MARIGOLD PLANT (GENUS TAGETES) - EFFECT OF SPECIES AND SAMPLE MANIPULATION SO CHROMATOGRAPHIA LA English DT Article DE GAS CHROMATOGRAPHY; GAS CHROMATOGRAPHY MASS SPECTROMETRY; TAGETES; PLANT VOLATILES; EXTRACTIONS; NATURAL INSECTICIDES; MOSQUITOS ID ALPHA-TERTHIENYL; MINUTA; OIL; PYRETHRINS; ERECTA; LARVAE AB Volatiles from three species of the genus tagetes, commonly called marigold have been isolated and characterized. Simultaneous steam distillation extractions (SSDE) produced consistently extracts of higher insecticidal activity than Soxhlet extractions. Methylene chloride was the best solvent. Volatiles isolated from the minutae species showed higher activity than those from patula and erecta. Comparison of extracts from the flower, foliage and roots of the plant showed that most of the activity is located in the flower. The volatiles are highly effective toward both larvae and adult mosquitoes. C1 USA,BIOMED RES & DEV LAB,FREDERICK,MD 21702. RP WELLS, C (reprint author), UNIV ALABAMA,DEPT CHEM,TUSCALOOSA,AL 35487, USA. NR 37 TC 15 Z9 15 U1 1 U2 4 PU FRIEDR VIEWEG SOHN VERLAG GMBH PI WIESBADEN 1 PA PO BOX 5829, W-6200 WIESBADEN 1, GERMANY SN 0009-5893 J9 CHROMATOGRAPHIA JI Chromatographia PD FEB PY 1993 VL 35 IS 3-4 BP 209 EP 215 DI 10.1007/BF02269705 PG 7 WC Biochemical Research Methods; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA KP313 UT WOS:A1993KP31300015 ER PT J AU LECKIE, RG DELAPLAIN, CB WATABE, JT DARROW, M AF LECKIE, RG DELAPLAIN, CB WATABE, JT DARROW, M TI THYROID HEMIAGENESIS BY I-123 THYROID SCAN WITH HIGH-RESOLUTION REAL-TIME ULTRASOUND CONFIRMATION SO CLINICAL NUCLEAR MEDICINE LA English DT Note C1 TRIPLER ARMY MED CTR,DEPT RADIOL,NUCL MED SERV,HONOLULU,HI 96859. NR 8 TC 4 Z9 4 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0363-9762 J9 CLIN NUCL MED JI Clin. Nucl. Med. PD FEB PY 1993 VL 18 IS 2 BP 161 EP 163 DI 10.1097/00003072-199302000-00021 PG 3 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA KL748 UT WOS:A1993KL74800021 PM 8432068 ER PT J AU KANDASAMY, SB MOTT, T HARRIS, AH AF KANDASAMY, SB MOTT, T HARRIS, AH TI EFFECT OF ONDANSETRON ON RADIATION-INDUCED HYPOTHERMIA IN RATS SO CLINICAL PHARMACOLOGY & THERAPEUTICS LA English DT Meeting Abstract C1 USA,RADIOBIOL RES INST,DEPT BEHAV SCI,BETHESDA,MD 20889. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0009-9236 J9 CLIN PHARMACOL THER JI Clin. Pharmacol. Ther. PD FEB PY 1993 VL 53 IS 2 BP 228 EP 228 PG 1 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA KP269 UT WOS:A1993KP26900370 ER PT J AU EASA, D MUNDIE, TG FINN, KC TAKENAKA, W BALARAMAN, V AF EASA, D MUNDIE, TG FINN, KC TAKENAKA, W BALARAMAN, V TI COMPARISON OF INCREMENTAL CONTINUOUS NEGATIVE EXTRATHORACIC PRESSURE VS POSITIVE END-EXPIRATORY PRESSURE IN SALINE-LAVAGED MECHANICALLY VENTILATED PIGLETS SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 UNIV HAWAII,TRIPLER ARMY MED CTR,KAPIOLANI MED CTR,HONOLULU,HI 96822. NR 0 TC 0 Z9 0 U1 0 U2 1 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 SN 0009-9279 J9 CLIN RES JI Clin. Res. PD FEB PY 1993 VL 41 IS 1 BP A28 EP A28 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA KH410 UT WOS:A1993KH41000148 ER PT J AU IWAMOTO, LM MARINKOVICH, GA NAKAMURA, KT AF IWAMOTO, LM MARINKOVICH, GA NAKAMURA, KT TI ENDOTOXIN LIPOPOLYSACCHARIDE DIFFERENTIALLY AFFECTS AIRWAY AND VASCULAR SMOOTH-MUSCLE CONTRACTILITY IN NEWBORN GUINEA-PIGS SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 UNIV HAWAII,KAPIOLANI MED CTR,HONOLULU,HI 96822. UNIV HAWAII,TRIPLER ARMY MED CTR,HONOLULU,HI 96822. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 SN 0009-9279 J9 CLIN RES JI Clin. Res. PD FEB PY 1993 VL 41 IS 1 BP A96 EP A96 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA KH410 UT WOS:A1993KH41000525 ER PT J AU MARINKOVICH, GA PICHOFF, BE IWAMOTO, LM NAKAMURA, KT AF MARINKOVICH, GA PICHOFF, BE IWAMOTO, LM NAKAMURA, KT TI ACUTE OXYGEN INJURY ATTENUATES THE RELAXING EFFECTS OF LOOP DIURETICS, FUROSEMIDE AND ETHACRYNIC-ACID, ON LARGE AIRWAYS OF NEWBORN GUINEA-PIGS SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 UNIV HAWAII,KAPIOLANI MED CTR,TRIPLER ARMY MED CTR,HONOLULU,HI 96822. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 SN 0009-9279 J9 CLIN RES JI Clin. Res. PD FEB PY 1993 VL 41 IS 1 BP A30 EP A30 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA KH410 UT WOS:A1993KH41000156 ER PT J AU MUNDIE, TG EASA, D FINN, KC STEVENS, EL HASHIRO, G BALARAMAN, V AF MUNDIE, TG EASA, D FINN, KC STEVENS, EL HASHIRO, G BALARAMAN, V TI PULMONARY-FUNCTION AND HEMODYNAMIC-EFFECTS OF INCREMENTAL POSITIVE END-EXPIRATORY PRESSURE IN VENTILATED PIGLETS WITH NORMAL LUNGS SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 TRIPLER ARMY MED CTR,HONOLULU,HI 96859. UNIV HAWAII,KAPIOLANI MED CTR,HONOLULU,HI 96822. NR 0 TC 0 Z9 0 U1 0 U2 1 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 SN 0009-9279 J9 CLIN RES JI Clin. Res. PD FEB PY 1993 VL 41 IS 1 BP A95 EP A95 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA KH410 UT WOS:A1993KH41000521 ER PT J AU SCHIFF, DE WASS, CA CRYZ, SJ CROSS, AS KIM, KS AF SCHIFF, DE WASS, CA CRYZ, SJ CROSS, AS KIM, KS TI ESTIMATION OF PROTECTIVE LEVELS OF ANTI-O-SPECIFIC LPS IMMUNOGLOBULIN-G SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 CHILDRENS HOSP LOS ANGELES,WALTER REED ARMY INST RES,WASHINGTON,DC. SWISS SERUM & VACCINE INST,BERN,SWITZERLAND. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 SN 0009-9279 J9 CLIN RES JI Clin. Res. PD FEB PY 1993 VL 41 IS 1 BP A43 EP A43 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA KH410 UT WOS:A1993KH41000230 ER PT J AU UYEHARA, CFT DESILVA, A MATSUDA, L KIRBY, RF ROBILLARD, JE NAKAMURA, KT AF UYEHARA, CFT DESILVA, A MATSUDA, L KIRBY, RF ROBILLARD, JE NAKAMURA, KT TI REMOVAL OF MATERNAL INFLUENCE IN THE NEONATAL-PERIOD DOES NOT ALTER THE DEVELOPMENT OF GENETIC-HYPERTENSION IN ARTIFICIALLY REARED SPONTANEOUSLY HYPERTENSIVE RATS (SHR) SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 UNIV IOWA,TRIPLER ARMY MED CTR,IOWA CITY,IA 52242. UNIV HAWAII,HONOLULU,HI 96822. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 SN 0009-9279 J9 CLIN RES JI Clin. Res. PD FEB PY 1993 VL 41 IS 1 BP A111 EP A111 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA KH410 UT WOS:A1993KH41000605 ER PT J AU LUTTRELL, WE OLAJOS, EJ PLEBAN, PA AF LUTTRELL, WE OLAJOS, EJ PLEBAN, PA TI CHANGE IN HEN SCIATIC-NERVE CALCIUM AFTER A SINGLE ORAL DOSE OF TRI-O-TOLYL PHOSPHATE SO ENVIRONMENTAL RESEARCH LA English DT Article; Proceedings Paper CT 4TH INTERNATIONAL SYMP ON NEUROBEHAVIORAL METHODS AND EFFECTS IN OCCUPATIONAL AND ENVIRONMENTAL HEALTH CY JUL 08-11, 1991 CL TOKYO, JAPAN ID INDUCED DELAYED POLYNEUROPATHY; NEUROPATHY C1 USA,CTR CHEM RES & DEV,ABERDEEN PROVING GROUND,MD 21010. OLD DOMINION UNIV,DEPT CHEM SCI,NORFOLK,VA 23529. RP LUTTRELL, WE (reprint author), EASTERN VIRGINIA MED SCH,DEPT PHARMACOL,NORFOLK,VA 23501, USA. NR 11 TC 3 Z9 3 U1 0 U2 0 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0013-9351 J9 ENVIRON RES JI Environ. Res. PD FEB PY 1993 VL 60 IS 2 BP 290 EP 294 DI 10.1006/enrs.1993.1038 PG 5 WC Environmental Sciences; Public, Environmental & Occupational Health SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA KQ406 UT WOS:A1993KQ40600015 PM 8472659 ER PT J AU SPARENBORG, S BRENNECKE, LH BEERS, ET AF SPARENBORG, S BRENNECKE, LH BEERS, ET TI PHARMACOLOGICAL DISSOCIATION OF THE MOTOR AND ELECTRICAL ASPECTS OF CONVULSIVE STATUS EPILEPTICUS INDUCED BY THE CHOLINESTERASE INHIBITOR SOMAN SO EPILEPSY RESEARCH LA English DT Article DE ORGANOPHOSPHORUS AGENT; CONVULSIONS; SEIZURES; ANTICONVULSANTS; PATHOLOGY; STATUS EPILEPTICUS; POWER SPECTRAL ANALYSIS ID RATS; NEUROTOXICITY; ELECTROSHOCK; PATHOLOGY; MIDBRAIN; THERAPY; LESION; MONKEY AB In an effort to validate methods to be used in a screen for drugs effective as anticonvulsants for soman-induced convulsions, scopolamine (0.2 mg/kg) or diazepam (1 mg/kg) were given (i.m.) to male guinea pigs as a pretreatment 30 min before a convulsant dose of soman. Pyridostigmine, atropine and pralidoxime chloride also were given to counteract the lethality of soman. All animals challenged with soman and which did not receive either diazepam or scopolamine exhibited convulsive status epilepticus (SE), identified by continuous electrographic seizure activity (EGSA) and continuous motor convulsions. Despite the presence of continuous motor convulsions in all animals pretreated with diazepam and challenged with soman, EGSA was not observed in five of the seven animals. Continuous motor convulsions developed in four of seven animals pretreated with scopolamine and challenged with soman, but EGSA was not observed in any scopolamine-pretreated guinea pig. Neuronal necrosis was observed in the hippocampus, thalamus, amygdala, and cerebral and pyriform cortices in each animal with EGSA, but no brain damage was found in subjects without EGSA. Thus, although convulsions, EGSA and brain damage normally occur together in animals exposed to soman, the convulsions can be 'pharmacologically dissociated from the EGSA and brain damage, demonstrating that the clinically manifested convulsions are not dependent on EGSA recorded from the cortex or on abnormal activity which leads to neuronal necrosis in the forebrain. C1 USA,MED RES INST CHEM DEF,COMPARAT PATHOL BRANCH,ABERDEEN PROVING GROUND,MD 21010. USA,MED RES INST CHEM DEF,NEUROTOXICOL BRANCH,ABERDEEN PROVING GROUND,MD 21010. NR 35 TC 19 Z9 19 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0920-1211 J9 EPILEPSY RES JI Epilepsy Res. PD FEB PY 1993 VL 14 IS 2 BP 95 EP 103 DI 10.1016/0920-1211(93)90014-X PG 9 WC Clinical Neurology SC Neurosciences & Neurology GA KQ164 UT WOS:A1993KQ16400001 PM 8453954 ER PT J AU LI, J WIRTZ, RA SCHNEIDER, I MURATOVA, OV MCCUTCHAN, TF APPIAH, A HOLLINGDALE, MR AF LI, J WIRTZ, RA SCHNEIDER, I MURATOVA, OV MCCUTCHAN, TF APPIAH, A HOLLINGDALE, MR TI PLASMODIUM-FALCIPARUM - STAGE-SPECIFIC RIBOSOMAL-RNA AS A POTENTIAL TARGET FOR MONITORING PARASITE DEVELOPMENT IN ANOPHELES-STEPHENSI SO EXPERIMENTAL PARASITOLOGY LA English DT Article DE PLASMODIUM-FALCIPARUM; MALARIA; RIBOSOMAL-RNA PROBE; ANOPHELES-STEPHENSI; MOSQUITO; HYBRIDIZATION ID INFECTED MOSQUITOS; MALARIA; DIAGNOSIS; IDENTIFICATION; PROBE; DNA C1 WALTER REED ARMY INST RES,DEPT ENTOMOL,DIV COMMUNICABLE DIS & IMMUNOL,WASHINGTON,DC 20307. BIOMED RES INST,ROCKVILLE,MD 20852. NIAID,MALARIA RES LAB,BETHESDA,MD 20892. RP LI, J (reprint author), UNIFORMED SERV UNIV HLTH SCI,DEPT PREVENT MED & BIOMETR,4301 JOHNS BRIDGE RD,BETHESDA,MD 20814, USA. NR 20 TC 14 Z9 14 U1 0 U2 0 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0014-4894 J9 EXP PARASITOL JI Exp. Parasitol. PD FEB PY 1993 VL 76 IS 1 BP 32 EP 38 DI 10.1006/expr.1993.1004 PG 7 WC Parasitology SC Parasitology GA KP128 UT WOS:A1993KP12800004 PM 8467898 ER PT J AU GUPTA, N SIMONIS, GJ PHAM, J AF GUPTA, N SIMONIS, GJ PHAM, J TI FABRICATION OF AN OPTOELECTRONIC ALGAAS/GAAS WAVE-GUIDE NEURON SO IEEE PHOTONICS TECHNOLOGY LETTERS LA English DT Article AB A novel optical waveguide neuron is fabricated. It accepts two inputs, applies adjustable weights to them, sums the weighted inputs, and thresholds the sum to issue one output. An AlGaAs/GaAs p-i-n diode waveguide with a Wannier-Stark superlattice in the core is used. Two modulators and one saturable absorber are monolithically integrated on a 5-mum rib waveguide Y-junction combiner. A simple self-aligned single-mask liftoff technique with wet chemical etching is used. At 780 nm the weights vary from 1 to -25 dB/mm for reverse bias below 7 V, and a 25-dB thresholding nonlinearity is obtained. RP GUPTA, N (reprint author), USA,KLIN,ADELPHI,MD 20783, USA. RI Gupta, Neelam/B-8702-2013 NR 11 TC 1 Z9 1 U1 0 U2 2 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 1041-1135 J9 IEEE PHOTONIC TECH L JI IEEE Photonics Technol. Lett. PD FEB PY 1993 VL 5 IS 2 BP 175 EP 177 DI 10.1109/68.195995 PG 3 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA KN746 UT WOS:A1993KN74600020 ER PT J AU TSENG, JN KOMISAR, JL CHEN, JYJ HUNT, RE JOHNSON, AJ PITT, L RIVERA, J RUBLE, DL TROUT, R VEGA, A AF TSENG, JN KOMISAR, JL CHEN, JYJ HUNT, RE JOHNSON, AJ PITT, L RIVERA, J RUBLE, DL TROUT, R VEGA, A TI IMMUNITY AND RESPONSES OF CIRCULATING LEUKOCYTES AND LYMPHOCYTES IN MONKEYS TO AEROSOLIZED STAPHYLOCOCCAL ENTEROTOXIN-B SO INFECTION AND IMMUNITY LA English DT Article ID TOXIC-SHOCK SYNDROME; HUMAN T-CELLS; PEYERS PATCHES; UNSENSITIZED MONKEYS; ORAL IMMUNIZATION; PLASMA-CELLS; IGA SYSTEM; SUPERANTIGENS; STIMULATION; EPITHELIUM AB Rhesus monkeys immunized intramuscularly or orally with staphylococcal enterotoxin B (SEB) toxoid or SEB toxoid incorporated in microspheres made of poly(DL-lactide-co-glycolide) were challenged with a lethal dose of aerosolized SEB to study their immunity and cellular responses in the circulation. It was found that circulating antibodies play a critical role in preventing SEB from triggering toxicosis. Monkeys with high levels of antibodies survived, while those with low levels underwent 2 to 3 days of toxicosis and died. Intramuscular immunization induced high levels and oral immunization induced low levels of antibodies. The circulating antibodies in surviving monkeys decreased dramatically within 20 min and started to rebound at 90 min after SEB challenge. At 90 min, the dying monkeys showed in the circulation a dramatic increase of polymorphonuclear leukocytes and decreases of NK cells and monocytes (CD16 and CD56 markers) as well as of lymphocytes with HLA-DR, CD2, CD8, and IL2Ralpha (CD25) markers. The number of polymorphonuclear leukocytes showed an inverse correlation with the numbers of monocytes and various lymphocyte subpopulations which, except for IL-2R, CD16, and CD56(+) cells, showed a direct correlation with one another. The changes in the populations of leukocytes, monocytes, NK cells, and lymphocytes seem to be an indication of initial toxicosis; however, the roles of these cells in toxicosis and death remain to be defined. C1 USA,MED RES INST INFECT DIS,DIV DIS ASSESSMENT,FREDERICK,MD 21701. USA,MED RES INST INFECT DIS,DIV VET MED,FREDERICK,MD 21701. RP TSENG, JN (reprint author), WALTER REED ARMY INST RES,DIV PATHOL,DEPT EXPTL PATHOL,WASHINGTON,DC 20307, USA. NR 48 TC 14 Z9 15 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD FEB PY 1993 VL 61 IS 2 BP 391 EP 398 PG 8 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA KH674 UT WOS:A1993KH67400004 PM 8423069 ER PT J AU GREEN, SJ NACY, CA SCHREIBER, RD GRANGER, DL CRAWFORD, RM MELTZER, MS FORTIER, AH AF GREEN, SJ NACY, CA SCHREIBER, RD GRANGER, DL CRAWFORD, RM MELTZER, MS FORTIER, AH TI NEUTRALIZATION OF GAMMA INTERFERON AND TUMOR-NECROSIS-FACTOR-ALPHA BLOCKS INVIVO SYNTHESIS OF NITROGEN-OXIDES FROM L-ARGININE AND PROTECTION AGAINST FRANCISELLA-TULARENSIS INFECTION IN MYCOBACTERIUM-BOVIS BCG-TREATED MICE SO INFECTION AND IMMUNITY LA English DT Article ID MAMMALIAN NITRATE BIOSYNTHESIS; LEISHMANIA-MAJOR AMASTIGOTES; ACTIVATED MURINE MACROPHAGES; DEPENDENT KILLING MECHANISM; NATURAL-KILLER-CELLS; NITRIC-OXIDE; IFN-GAMMA; CYTO-TOXICITY; EFFECTOR MECHANISM; RIBONUCLEOTIDE REDUCTASE AB Peritoneal cells from Mycobacterium bovis BCG-infected C3H/HeN mice produced nitrite (NO2-, an oxidative end product of nitric oxide [NO] synthesis) and inhibited the growth of Francisella tularensis, a facultative intracellular bacterium. Both NO2- production and inhibition of bacterial growth were suppressed by N(G)-monomethyl-L-arginine, a substrate inhibitor of nitrogen oxidation of L-arginine, and monoclonal antibodies (MAbs) to gamma interferon (IFN-gamma) and tumor necrosis factor alpha (TNF-alpha). Intraperitoneal injection of mice with BCG increased urinary nitrate (NO3-) excretion coincident with development of activated macrophages capable of secreting nitrogen oxides and inhibiting F. tularensis growth in vitro. Eight days after BCG inoculation, mice survived a normally lethal intraperitoneal challenge with F. tularensis. Treatment of these BCG-infected mice with MAbs to IFN-gamma or TNF-alpha at the time of BCG inoculation reduced urinary NO3- levels to those found in normal uninfected mice for up to 14 days. The same anticytokine antibody treatment abolished BCG-mediated protection against F. tularensis: mice died within 4 to 6 days. Intraperitoneal administration of anti-IFN-gamma or anti-TNF-alpha antibody 8 days after BCG infection also reduced urinary NO3- and abolished protection against F. tularensis. Isotype control (immunoglobulin G) or anti-interleukin 4 MAbs had little effect on these parameters at any time of treatment. IFN-gamma and TNF-alpha were clearly involved in the regulation of macrophage activation by BCG in vivo. Protection against F. tularensis challenge by BCG depended upon the physiological generation of reactive nitrogen oxides induced by these cytokines. C1 WASHINGTON UNIV,SCH MED,DEPT PATHOL,ST LOUIS,MO 63110. DUKE UNIV,SCH MED,DEPT MED & INFECT DIS,DURHAM,NC 27710. RP GREEN, SJ (reprint author), WALTER REED ARMY INST RES,DEPT CELLULAR IMMUNOL,WASHINGTON,DC 20307, USA. RI Schreiber, Robert/A-1276-2013 OI Schreiber, Robert/0000-0001-6311-0432 NR 80 TC 106 Z9 107 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD FEB PY 1993 VL 61 IS 2 BP 689 EP 698 PG 10 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA KH674 UT WOS:A1993KH67400043 PM 8423095 ER PT J AU LESKOVAC, V PEGGINS, JO TRIVIC, S SVIRCEVIC, J POPOVIC, M STUPAR, M AF LESKOVAC, V PEGGINS, JO TRIVIC, S SVIRCEVIC, J POPOVIC, M STUPAR, M TI REDUCTION OF 1-NITROSO-2-NAPHTHOL BY NADPH IN THE PRESENCE OF LIVER-MICROSOMES SO INTERNATIONAL JOURNAL OF BIOCHEMISTRY LA English DT Article ID ARYL NITROSO-COMPOUNDS; OXIDASE AB 1. The endogenous, NADPH-supported production of H2O2 and of O2--radicals in liver microsomes, was very strongly enhanced in the presence of 1-nitroso-2-naphthol. 2. A 30-fold induction by NON was the consequence of its direct reduction to NON-radicals, catalyzed by microsomal NADPH:cytochrome P450 reductase. 3. Nitroso radicals reduce molecular oxygen to superoxide anion radicals, which were readily dismutated by superoxide dismutase to hydrogen peroxide. 4. O2--radicals were the sole precursors of all NON-induced production of H2O2 in liver microsomes. C1 FAC TECHNOL BEOGRAD,BELGRADE,YUGOSLAVIA. FAC SCI,YU-21000 NOVI SAD,YUGOSLAVIA. NUCL INST BORIS KIDRIC,BELGRADE,YUGOSLAVIA. WALTER REED ARMY INST RES,WASHINGTON,DC 20307. RP LESKOVAC, V (reprint author), FAC TECHNOL,BULEVAR AVNOJA 1,YU-21000 NOVI SAD,YUGOSLAVIA. NR 26 TC 3 Z9 3 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0020-711X J9 INT J BIOCHEM JI Int. J. Biochem. PD FEB PY 1993 VL 25 IS 2 BP 279 EP 286 DI 10.1016/0020-711X(93)90017-9 PG 8 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA KL920 UT WOS:A1993KL92000017 PM 8383068 ER PT J AU WELCH, ML JAMES, WD AF WELCH, ML JAMES, WD TI WIDESPREAD NEVUS-SPILUS SO INTERNATIONAL JOURNAL OF DERMATOLOGY LA English DT Article ID MALIGNANT-MELANOMA; LENTIGINOUS NEVUS; RISK FACTOR RP WELCH, ML (reprint author), WALTER REED ARMY MED CTR, SERV DERMATOL, WASHINGTON, DC 20307 USA. NR 19 TC 11 Z9 12 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0011-9059 EI 1365-4632 J9 INT J DERMATOL JI Int. J. Dermatol. PD FEB PY 1993 VL 32 IS 2 BP 120 EP 122 DI 10.1111/j.1365-4362.1993.tb01451.x PG 3 WC Dermatology SC Dermatology GA KK047 UT WOS:A1993KK04700013 PM 8440553 ER PT J AU SAAD, RW SAU, P MULVANEY, MP JAMES, WD AF SAAD, RW SAU, P MULVANEY, MP JAMES, WD TI INTRAVENOUS PYOGENIC GRANULOMA SO INTERNATIONAL JOURNAL OF DERMATOLOGY LA English DT Article ID EOSINOPHILIA; HYPERPLASIA; SKIN AB A 35-year-old male soldier presented with a 4-month history of a slowly enlarging, painless 'cyst' over his left temple. He denied any preceding trauma or puncture wounds and related that the lesion made it difficult for him to wear his protective helmet. There was a history of enlargement of the lesion during periods of vigorous exercise. Physical examination revealed an 8-mm pulsatile subcutaneous nodule apparently involving his left superficial temporal artery (Fig. 1). The overlying skin was slightly thinned but otherwise unaltered. The arteriovenous structures were isolated and ligated proximal and distal to the smooth, gray, pulsatile mass, which was then excised. Histologic sections from the nodule revealed a dilated vein with a broad-based, polypoid lesion occluding the lumen (Fig. 2). This lesion consisted of a lobular proliferation of capillaries some of which were embedded in a fibromyxoid stroma (Fig. 3). A few larger vessels coursed between these lobules and in many areas the capillary proliferation extended into the wall of the vein. The stroma contained scattered lymphocytes, plasma cells, and many eosinophils. Although focal areas of recent hemorrhage and hemosiderin pigment deposition were observed, no evidence of new or organizing thrombus was identified. RP SAAD, RW (reprint author), WALTER REED ARMY MED CTR, DERMATOL SERV, WASHINGTON, DC 20307 USA. NR 18 TC 14 Z9 14 U1 0 U2 1 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0011-9059 J9 INT J DERMATOL JI Int. J. Dermatol. PD FEB PY 1993 VL 32 IS 2 BP 130 EP 132 DI 10.1111/j.1365-4362.1993.tb01455.x PG 3 WC Dermatology SC Dermatology GA KK047 UT WOS:A1993KK04700017 PM 8440557 ER PT J AU PELLETIERE, SC AF PELLETIERE, SC TI THE LONGEST WAR - HIRO,D SO INTERNATIONAL JOURNAL OF MIDDLE EAST STUDIES LA English DT Book Review RP PELLETIERE, SC (reprint author), USA,COLL WAR,INST STRATEG STUDIES,CARLISLE,PA, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 40 WEST 20TH STREET, NEW YORK, NY 10011-4211 SN 0020-7438 J9 INT J MIDDLE E STUD JI Int. J. Middle East Stud. PD FEB PY 1993 VL 25 IS 1 BP 180 EP 181 PG 2 WC Area Studies SC Area Studies GA KG769 UT WOS:A1993KG76900042 ER PT J AU PETITON, S SAAD, Y WU, KS FERNG, W AF PETITON, S SAAD, Y WU, KS FERNG, W TI BASIC SPARSE-MATRIX COMPUTATIONS ON THE CM-5 SO INTERNATIONAL JOURNAL OF MODERN PHYSICS C-PHYSICS AND COMPUTERS LA English DT Article; Proceedings Paper CT 1ST EUROPEAN CONNECTION MACHINE USERS MEETING : SCIENCE ON THE CONNECTION MACHINE CY JUN 16-17, 1992 CL WUPPERTAL, GERMANY SP DANISH COMP CTR RES & EDUC, EDINBURGH PARALLEL COMP CTR, ETABLISSEMENT TECH CENT ARMEMENT, GENEVA UNIV, GESELL MATH & DATENVERARBEIT, INST PHYS GLOVE, INST NATL RECH INFORMAT & AUTOMAT, INST RIC SISTEMI INFORMAT PARLLELI, KUNGLIGA TEKNISKA HOGSKOLAN, PARMA UNIV AB This paper presents a preliminary experimental study of the performance of basic sparse matrix computations on the CM-5. We concentrate on examining various ways of performing general sparse matrix-vector operations and the basic primitives on which these are based. We compare various data structures for storing sparse matrices and their corresponding matrix - vector operations. Both SPMD and Data parallel modes are examined and a comparison of the two modes is made. C1 ETAB TECHN CENT ARMEMENT,SITE EXPTL HYPERPARALLELISME,ARCUEIL,FRANCE. YALE UNIV,DEPT COMP SCI,NEW HAVEN,CT 06520. UNIV MINNESOTA,DEPT COMP SCI,MINNEAPOLIS,MN 55455. UNIV MINNESOTA,ARMY HIGH PERFORMANCE COMP RES CTR,MINNEAPOLIS,MN 55455. NR 11 TC 0 Z9 0 U1 0 U2 1 PU WORLD SCIENTIFIC PUBL CO PTE LTD PI SINGAPORE PA JOURNAL DEPT PO BOX 128 FARRER ROAD, SINGAPORE 9128, SINGAPORE SN 0129-1831 J9 INT J MOD PHYS C JI Int. J. Mod. Phys. C-Phys. Comput. PD FEB PY 1993 VL 4 IS 1 BP 65 EP 83 DI 10.1142/S0129183193000082 PG 19 WC Computer Science, Interdisciplinary Applications; Physics, Mathematical SC Computer Science; Physics GA LU429 UT WOS:A1993LU42900008 ER PT J AU WEISS, GR BROWN, TD KUHN, JG VONHOFF, DD EARHART, RH ADAMS, WJ BREWER, JE HOSLEY, JD KASUNIC, DA AF WEISS, GR BROWN, TD KUHN, JG VONHOFF, DD EARHART, RH ADAMS, WJ BREWER, JE HOSLEY, JD KASUNIC, DA TI A PHASE-I CLINICAL AND PHARMACOKINETIC STUDY OF THE ORAL AND THE ORAL INTRAVENOUS ADMINISTRATION OF MENOGARIL SO INVESTIGATIONAL NEW DRUGS LA English DT Article DE MENOGARIL; PHASE-I; PHARMACOKINETICS ID TRIAL; SCHEDULE; AGENT AB Thirty-five patients with advanced refractory cancer were enrolled on this phase I study of menogaril administered orally every 4 weeks at dosages ranging from 85 mg/m2 to 625 mg/m2. An additional 12 patients received alternating oral and IV doses of menogaril (250 mg/m2 IV; 250-500 mg/m2 oral) with accompanying blood and urine sampling for pharmacokinetics analysis. Nausea and vomiting were the dose-limiting toxicities at the 625 mg/m2 dosage level; vomiting was inadequately relieved by prophylactic ewing at this dosage level. Other toxicities included sporadic leukopenia at all dosage levels; at dosages of 500 mg/m2 and 625 mg/m2, leukopenia < 3000/mul occurred in 7 of 24 patients. Anemia and thrombocytopenia were much less frequent toxicities. Among the patients receiving IV menogaril, peripheral vein phlebitis, leukopenia and anemia were the predominant toxicities. No antitumor responses were observed, yet one patient with non-small cell lung cancer experienced a 30% reduction in metastatic tumor nodules. For the patients receiving alternating oral and IV menogaril, comparative pharmacokinetic analyses were performed by HPLC. After oral administration, maximum plasma concentrations were achieved in an average of 6 hours; maximum plasma concentrations were less than one-quarter of those achieved after intravenous administration. The harmonic mean (+/- SD) terminal disposition half-life after oral dosing was 29.3 +/- 9.2 hours; mean systemic bioavailability was 33.6 +/- 10.5% after oral dosing. Forty-eight hours after an oral dose, mean cumulative urinary excretions of menogaril and the primary metabolite, N-demethylmenogaril, were 4.00 +/- 0.96% and 0.44 +/- 0.16%, respectively. Because of the poor tolerance of oral menogaril and minimal evidence of biological activity, this schedule of drug administration is not recommended for phase II evaluation. Based on this and other published studies of oral menogaril, frequent chronic low-intermediate dosages of the drug may be given orally with potentially better tolerance and antitumor activity. C1 UNIV TEXAS,HLTH SCI CTR,DEPT MED,DIV MED ONCOL,SAN ANTONIO,TX 78284. UNIV TEXAS,HLTH SCI CTR,SCH PHARM,SAN ANTONIO,TX 78284. BROOKE ARMY MED CTR,DEPT MED,HEMATOL ONCOL SECT,FT SAM HOUSTON,TX 78234. UPJOHN CO,KALAMAZOO,MI 49001. FU NCI NIH HHS [NCI NO1-CM-27542]; NCRR NIH HHS [RR-01346] NR 18 TC 5 Z9 5 U1 0 U2 1 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 0167-6997 J9 INVEST NEW DRUG JI Invest. New Drugs PD FEB PY 1993 VL 11 IS 1 BP 17 EP 27 DI 10.1007/BF00873906 PG 11 WC Oncology; Pharmacology & Pharmacy SC Oncology; Pharmacology & Pharmacy GA LF647 UT WOS:A1993LF64700003 PM 8349432 ER PT J AU MALONE, JD SMITH, ES SHEFFIELD, J BIGELOW, D HYAMS, KC BEARDSLEY, SG LEWIS, RS ROBERTS, CR AF MALONE, JD SMITH, ES SHEFFIELD, J BIGELOW, D HYAMS, KC BEARDSLEY, SG LEWIS, RS ROBERTS, CR TI COMPARATIVE-EVALUATION OF 6 RAPID SEROLOGICAL TESTS FOR HIV-1 ANTIBODY SO JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY LA English DT Article DE HIV-1; ANTIBODY; UNITED-STATES MILITARY; SEROLOGICAL ASSAYS ID HUMAN-IMMUNODEFICIENCY-VIRUS; DEVELOPING-COUNTRIES; AGGLUTINATION ASSAY; SCREENING ASSAYS; SEROPOSITIVITY AB Six commercial rapid test kits for HIV-1 antibody were evaluated. Four laboratory technologists tested sera from four groups of U.S. military personnel or dependents: 202 subjects positive tor HIV-1 antibody by Western blot, 200 seronegative voluntary blood donors, 199 seronegative obstetrics/gynecology patients. and 99 subjects with sera reactive by ELISA but negative by recombinant protein EIA and indeterminate by Western blot. The three tests using solid-phase immunoassay technology demonstrated the highest mean sensitivity (>99%) and specificity (>91%) for all groups tested, including sera indeterminate by Western blot. Two dot-immunoblot assays were less specific, possibly due to indistinct reaction end points, and a latex agglutination assay was also less specific because of difficulty distinguishing reactive results from the granular background. In an ''ease-of-use'' assessment, solid-phase capture immunoassays required less time and equipment and were easier to interpret than other testing methods. Solid-phase capture immunoassays for HIV-1 antibody may be suitable for use in emergency situations and in developing countries because they are highly sensitive and specific and are rapidly performed with minimal laboratory equipment. C1 BROOKE ARMY MED CTR,SAN ANTONIO,TX. WALTER REED ARMY INST RES,ROCKVILLE,MD. WALTER REED ARMY INST RES,DIV RETROVIROL,DEPT DIAGNOST RETROVIROL,WASHINGTON,DC 20307. USN,MED RES INST,BETHESDA,MD 20814. RP MALONE, JD (reprint author), USN,NATL MED CTR,DIV INFECT DIS,BETHESDA,MD 20014, USA. NR 11 TC 38 Z9 38 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 1077-9450 J9 J ACQ IMMUN DEF SYND JI J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. PD FEB PY 1993 VL 6 IS 2 BP 115 EP 119 PG 5 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA KK252 UT WOS:A1993KK25200002 PM 8433277 ER PT J AU SMITH, PB SNYDER, AP AF SMITH, PB SNYDER, AP TI CHARACTERIZATION OF BACTERIA BY OXIDATIVE AND NONOXIDATIVE PYROLYSIS-GAS CHROMATOGRAPHY ION TRAP MASS-SPECTROMETRY SO JOURNAL OF ANALYTICAL AND APPLIED PYROLYSIS LA English DT Article DE BACTERIA; GAS CHROMATOGRAPHY; ION TRAP MASS SPECTROMETRY; PYROLYSIS ID FATTY-ACIDS; COLUMN AB Three bacterial species were characterized by analysis of their lipid composition with a quartz tube pyrolysis-gas chromatography/mass spectrometry (Py-GC/MS) system. Bacteria were pyrolyzed under both oxidative (in air) and non-oxidative (in helium) conditions. The components of the bacteria, generated by pyrolysis, were mass analyzed using an ion trap detector following chromatographic separation on a short (5 m) capillary GC column. The total analysis time, including sample processing, was under 15 min. The bacteria were differentiated from each other by visual examination of the patterns of their lipid components. Despite relatively extensive data analysis, the results obtained under oxidative pyrolysis conditions were indistinguishable from those obtained under non-oxidative pyrolysis conditions. C1 USA,CTR CHEM RES DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010. RP SMITH, PB (reprint author), GEOCENTERS INC,GUNPOWDER BRANCH,POB 68,ABERDEEN PROVING GROUND,MD 21010, USA. NR 14 TC 9 Z9 9 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-2370 J9 J ANAL APPL PYROL JI J. Anal. Appl. Pyrolysis PD FEB PY 1993 VL 24 IS 3 BP 199 EP 210 DI 10.1016/0165-2370(93)85001-F PG 12 WC Chemistry, Analytical; Spectroscopy SC Chemistry; Spectroscopy GA KR985 UT WOS:A1993KR98500001 ER PT J AU ZHOU, WM DUTTA, M SHEN, H PAMULAPATI, J BENNETT, BR PERRY, CH WEYBURNE, DW AF ZHOU, WM DUTTA, M SHEN, H PAMULAPATI, J BENNETT, BR PERRY, CH WEYBURNE, DW TI INVESTIGATION OF NEAR INTERFACE PROPERTIES IN SEMIINSULATING INP SUBSTRATES WITH EPITAXIAL GROWN INGAAS AND INALAS BY PHOTOREFLECTANCE SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID GAAS; ELECTROREFLECTANCE; CHARGE AB An extensive photoreflectance (PR) study has been done on a series of undoped and n-type, InGaAs and InAlAs molecular beam epitaxy (MBE) grown layers with different In mole fractions, and epilayer thicknesses on Fe-doped semi-insulating (SI)-InP substrates. Three substrate features were observed in the spectra. From investigations of the temperature dependence, time constant dependence, and an additional cw light beam intensity dependence, they were identified as an excitonic transition from the substrate, a free electron transition near the interface which gives a Franz-Keldysh oscillation, and a transition from the spin-orbit split-off valence band. The Franz-Keldysh effect indicates that a temperature dependent built-in electric field is formed near the interface. The dependence of the field on doping concentration, strain, or epilayer composition (band gap) was insignificant. The PR signal from a SI-InP wafer after a pre-MBE-growth heating was found to be strongly enhanced over that from an untreated wafer. This signal was even more enhanced after an epilayer was grown on top, indicating the formation of a built-in field. These results are indicative of a redistribution of charge near the interface/surface in the process of MBE growth; the associated PR signal (phase) could be used for in situ monitoring of epilayer growth on SI-InP wafers. C1 MIT,CAMBRIDGE,MA 02139. NORTHEASTERN UNIV,BOSTON,MA 02115. USAF,ROME LAB,SYST COMMAND,BEDFORD,MA 01731. GEOCENTERS INC,LAKE HOPATCONG,NJ 07849. RP ZHOU, WM (reprint author), USA,RES LAB,EPSD,FT MONMOUTH,NJ 07703, USA. RI Bennett, Brian/A-8850-2008 OI Bennett, Brian/0000-0002-2437-4213 NR 25 TC 20 Z9 20 U1 2 U2 5 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD FEB 1 PY 1993 VL 73 IS 3 BP 1266 EP 1271 DI 10.1063/1.353268 PG 6 WC Physics, Applied SC Physics GA KK921 UT WOS:A1993KK92100039 ER PT J AU KATZ, RW HOLLINGER, JO REDDI, AH AF KATZ, RW HOLLINGER, JO REDDI, AH TI THE FUNCTIONAL EQUIVALENCE OF DEMINERALIZED BONE AND TOOTH MATRICES IN ECTOPIC BONE INDUCTION SO JOURNAL OF BIOMEDICAL MATERIALS RESEARCH LA English DT Article ID INCISOR DENTIN CONTAINS; WATER-SOLUBLE PROTEINS; DISSOCIATIVE EXTRACTION; MORPHOGENETIC PROTEIN; EXTRACELLULAR-MATRIX; DELIVERY VEHICLE; CELLS-INVITRO; BOVINE; DIFFERENTIATION; PURIFICATION AB The objective of this study was to determine whether demineralized rat incisor matrices were a more potent inducer of ectopic endochondral bone formation than demineralized diaphyseal bone matrices derived from the same donors. Twenty-five-milligram disks of de-mineralized bone or tooth matrix obtained from adolescent Long-Evans rats were implanted in a standardized ectopic site. Biochemical and histometric measurements of bone formation revealed that the two matrices were functionally equivalent inducers of endochondral bone formation. The induced pellicle of bone reached a maturation point 18 days after implantation. Dentin matrix implants generated a significantly greater amount of mineralized tissue than did bone matrix implants. This difference could be explained on the basis of remineralization of the dentin particles to a greater degree than the bone matrix particles. Initial observations suggesting a more robust osteoinductive activity in demineralized incisor matrix can be attributed to the decreasing activity of bone matrix from older donors when compared to younger donors. The extent of osteoinduction by the two substrata was equivalent when the matrices were matched for age. C1 NIDR,CLIN INVEST & PATIENT CARE BRANCH,BETHESDA,MD 20892. WALTER REED ARMY MED CTR,INST DENT RES,BONE PHYSIOL BRANCH,WASHINGTON,DC 20307. JOHNS HOPKINS UNIV,MED CTR,DEPT ORTHOPED SURG,BALTIMORE,MD 21205. NR 34 TC 13 Z9 14 U1 0 U2 1 PU JOHN WILEY & SONS INC PI NEW YORK PA 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0021-9304 J9 J BIOMED MATER RES JI J. Biomed. Mater. Res. PD FEB PY 1993 VL 27 IS 2 BP 239 EP 245 DI 10.1002/jbm.820270214 PG 7 WC Engineering, Biomedical; Materials Science, Biomaterials SC Engineering; Materials Science GA KG410 UT WOS:A1993KG41000013 PM 8436581 ER PT J AU BURKOT, TR WIRTZ, RA LUFT, B PIESMAN, J AF BURKOT, TR WIRTZ, RA LUFT, B PIESMAN, J TI AN OSPA ANTIGEN-CAPTURE ENZYME-LINKED-IMMUNOSORBENT-ASSAY FOR DETECTING NORTH-AMERICAN ISOLATES OF BORRELIA-BURGDORFERI IN LARVAL AND NYMPHAL IXODES-DAMMINI SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID POLYMERASE CHAIN-REACTION; LYME-DISEASE SPIROCHETE; MONOCLONAL-ANTIBODY; BABESIA-MICROTI; TICK; CULTIVATION; INFECTION; PROTEINS; TESTS AB An antigen-capture enzyme-linked immunosorbent assay (ELISA) was developed for detecting North American isolates of Borrelia burgdorferi in larval, nymphal, and adult ticks. The assay uses an anti-OspA monoclonal antibody (H5332) for antigen capture and biotin-labelled polyclonal sera with streptavidin-horseradish peroxidase for signal generation. The assay recognized 15 of 15 North American B. burgdorferi isolates and did not cross-react with spirochete antigens of Borrelia hermsii, Borrelia turicatae, Borrelia coriaceae, or Borrelia parkeri, or with tick antigens of Ixodes dammini, Ixodes scapularis, Ixodes pacificus, Ixodes cookei, Ixodes angustus, or Ambylomma americanum. The assay, with a sensitivity of less than 150 spirochetes, can detect infections in larval, nymphal, and adult ticks. In addition to fresh ticks, B. burgdorferi infections in ticks stored frozen, dried, or in 70% ethanol can be determined with the assay. C1 WALTER REED ARMY INST RES,DEPT ENTOMOL,WASHINGTON,DC 20307. SUNY STONY BROOK,DEPT MED,STONY BROOK,NY 11794. RP BURKOT, TR (reprint author), CTR DIS CONTROL,DIV VECTOR BORNE INFECT DIS,POB 2087,FT COLLINS,CO 80522, USA. RI Burkot, Thomas/C-6838-2013; OI Luft, Benjamin/0000-0001-9008-7004 NR 36 TC 23 Z9 23 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD FEB PY 1993 VL 31 IS 2 BP 272 EP 278 PG 7 WC Microbiology SC Microbiology GA KH751 UT WOS:A1993KH75100019 PM 8432812 ER PT J AU JACOBS, JP MURRAY, KJ SCHULTZ, CJ WILSON, JF GOSWITZ, MS STEVENS, CW COX, JD AF JACOBS, JP MURRAY, KJ SCHULTZ, CJ WILSON, JF GOSWITZ, MS STEVENS, CW COX, JD TI CENTRAL LYMPHATIC IRRADIATION FOR STAGE-III NODULAR MALIGNANT-LYMPHOMA - LONG-TERM RESULTS SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Article ID NON-HODGKINS-LYMPHOMAS; SINGLE AGENT CHEMOTHERAPY; COMBINATION CHEMOTHERAPY; BODY IRRADIATION; MIXED LYMPHOMA; TRIAL; HISTOLOGIES; MANAGEMENT C1 MED COLL WISCONSIN,DEPT SYNTHESE ORGAN,8700 W WISCONSIN AVE,MILWAUKEE,WI 53226. UNIV TEXAS,MD ANDERSON CANC CTR,HOUSTON,TX 77025. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. GEORGETOWN UNIV,MED CTR,WASHINGTON,DC 20007. NR 24 TC 45 Z9 45 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0732-183X J9 J CLIN ONCOL JI J. Clin. Oncol. PD FEB PY 1993 VL 11 IS 2 BP 233 EP 238 PG 6 WC Oncology SC Oncology GA KK441 UT WOS:A1993KK44100006 PM 8426199 ER PT J AU DUFFY, PE PIMENTA, P KASLOW, DC AF DUFFY, PE PIMENTA, P KASLOW, DC TI PGS28 BELONGS TO A FAMILY OF EPIDERMAL GROWTH-FACTOR LIKE ANTIGENS THAT ARE TARGETS OF MALARIA TRANSMISSION-BLOCKING ANTIBODIES SO JOURNAL OF EXPERIMENTAL MEDICINE LA English DT Note ID PLASMODIUM-FALCIPARUM; SEXUAL STAGES; GALLINACEUM; IMMUNITY; DNA; TRANSFORMATION; EXPRESSION; PROTEINS; ZYGOTES; VACCINE AB Although Pgs28, a 28-kD surface protein of Plasmodium gallinaceum ookinetes, was previously thought not to be a target of transmission-blocking antibodies, we found that polyclonal antisera to Pgs28 completely blocked parasite infectivity to Aedes aegypti mosquitoes. Antisera raised against reduced Pgs28 were less effective in blocking transmission than were antisera to nonreduced Pgs28; thus, the target epitope(s) of transmission-blocking antibodies appears to be conformation dependent. In stage-specific assays, polyclonal antisera impaired the in vitro transformation of zygotes to mature ookinetes, as well as the in vivo development of mature ookinetes to oocysts. Using microsequence of immunoaffinity-purified Pgs28, we cloned the 666-bp open reading frame of the Pgs28 gene. The deduced amino acid sequence of Pgs28 is strikingly similar to that of a R gallinaceum zygote surface protein, Pgs25, and its P. falciparum analogue, Pfs25. Pgs28, like Pgs25 and Pfs25, has a presumptive secretory signal sequence, followed by four epidermal growth factor-like domains, and a terminal hydrophobic region. C1 NIAID,MALARIA RES LAB,MOLEC VACCINE SECT,BLDG 4 ROOM B1-37,BETHESDA,MD 20892. NIAID,PARASIT DIS LAB,BETHESDA,MD 20892. WALTER REED ARMY INST RES,DEPT MED,WASHINGTON,DC 20307. NR 22 TC 80 Z9 84 U1 1 U2 1 PU ROCKEFELLER UNIV PRESS PI NEW YORK PA 1114 FIRST AVE, 4TH FL, NEW YORK, NY 10021 SN 0022-1007 J9 J EXP MED JI J. Exp. Med. PD FEB 1 PY 1993 VL 177 IS 2 BP 505 EP 510 DI 10.1084/jem.177.2.505 PG 6 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA KJ441 UT WOS:A1993KJ44100027 PM 8426118 ER PT J AU SOLOMON, BL FEIN, HG SMALLRIDGE, RC AF SOLOMON, BL FEIN, HG SMALLRIDGE, RC TI USEFULNESS OF ANTIMICROSOMAL ANTIBODY-TITERS IN THE DIAGNOSIS AND TREATMENT OF POSTPARTUM THYROIDITIS SO JOURNAL OF FAMILY PRACTICE LA English DT Article DE PUERPERIUM; THYROIDITIS; AUTOANTIBODIES ID TERM FOLLOW-UP; LYMPHOCYTIC THYROIDITIS; DYSFUNCTION; HYPOTHYROIDISM; PREVALENCE AB Background. Postpartum thyroiditis is a common but frequently unrecognized disorder, affecting approximately 5% of women during the first 12 months after delivery, We investigated whether the antimicrosomal antibody titer could be used to determine which women with positive titers postpartum (1) might develop symptomatic or biochemical abnormalities within the first postpartum year (early disease), (2) might require therapy with thyroid hormone, and (3) might have persistent abnormalities (late disease). Methods. Women (n = 55) who had positive antimicrosomal antimicrosomal antibody titers at delivery were prospectively followed for 11 to 45 months. Titers were evaluated again at 6 to 10 weeks postpartum and approximately every 8 weeks for the first year. Results. Early disease occurred in 40 of 55 (73%) women, late disease occurred in 29 of 55 (53%) women, and treatment was required by 21 of 55 (38%) women. The occurrence of early disease was associated with the occurrence of late disease (P < .05). The chances of developing early disease were 6 to 1 (P .01) when serum titers of antimicrosomal antibodies were greater-than-or-equal-to 400 at delivery, and 5 to 1 (P = .02) when titers were greater-than-or-equal-to 1600 at 6 to 10 weeks postpartum. The chances of being given thyroid hormone therapy were 23 to 1 (P = .006) when titers at delivery were greater-than-or-equal-to 6400, and 6 to 1 when titers at 6 to 10 weeks postpartum were greater-than-or-equal-to 6400 (P = .004). Titers were not useful in estimating who would have late disease. Conclusions. Screening for postpartum thyroid dysfunction after delivery using antimicrosomal antibody titers is highly useful. The titer value can help guide the physician in the care of patients with postpartum thyroiditis whose discase may not be self-limiting an probably require thyroid hormone therapy. C1 WALTER REED ARMY MED CTR,DEPT CLIN PHYSIOL,WASHINGTON,DC 20307. RP SOLOMON, BL (reprint author), WALTER REED ARMY MED CTR,DEPT CLIN INVEST,ENDOCRINOL METAB SERV 7D,WASHINGTON,DC 20307, USA. NR 13 TC 22 Z9 23 U1 0 U2 0 PU APPLETON & LANGE PI E NORWALK PA 25 VAN ZANT ST, E NORWALK, CT 06855 SN 0094-3509 J9 J FAM PRACTICE JI J. Fam. Pract. PD FEB PY 1993 VL 36 IS 2 BP 177 EP 182 PG 6 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA KL864 UT WOS:A1993KL86400017 PM 8426137 ER PT J AU SETHABUTR, O VENKATESAN, M MURPHY, GS EAMPOKALAP, B HOGE, CW ECHEVERRIA, P AF SETHABUTR, O VENKATESAN, M MURPHY, GS EAMPOKALAP, B HOGE, CW ECHEVERRIA, P TI DETECTION OF SHIGELLAE AND ENTEROINVASIVE ESCHERICHIA-COLI BY AMPLIFICATION OF THE INVASION PLASMID ANTIGEN H DNA-SEQUENCE IN PATIENTS WITH DYSENTERY SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID FLEXNERI AB Detection of Shigella organisms and enteroinvasive Escherichia coli (EIEC) by polymerase chain reaction (PCR) was evaluated in 20 patients with dysentery before and in 17 of the 20 after treatment with ciprofloxacin. DNA sequences coding for IpaH antigen, a multiple copy sequence found on the chromosome, and the invasion plasmid locus (ial) was detected after DNA amplification in 13 stools from patients from whom shigellae or EIEC were isolated but not in 21 nondysenteric stools containing other enteric bacteria. Although shigellae or EIEC were not isolated from any patient with dysentery after ciprofloxacin treatment, IpaH and ial sequences were found after PCR amplification in 7 patients after treatment with ciprofloxacin. IpaH sequences alone were detected in 4 patients; DNA augmentation of IpaH in stools is a specific way to identify Shigella or EIEC infection in persons from whom cultures cannot be obtained promptly after the onset of diarrhea or who have received antibiotics. C1 ARMED FORCES RES INST MED SCI,DEPT BACTERIOL IMMUNOL & MOLEC GENET,BANGKOK,THAILAND. BAMRASNARADURA HOSP,NONTHABURI,THAILAND. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT BACTERIAL IMMUNOL,WASHINGTON,DC 20307. NAVAL MED RES,JAKARTA,INDONESIA. NR 15 TC 111 Z9 114 U1 0 U2 4 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD FEB PY 1993 VL 167 IS 2 BP 458 EP 461 PG 4 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA KJ487 UT WOS:A1993KJ48700030 PM 8421181 ER PT J AU MARINO, MT ASP, AA BUDAYER, AA MARSDEN, JS STREWLER, GJ AF MARINO, MT ASP, AA BUDAYER, AA MARSDEN, JS STREWLER, GJ TI HYPERCALCEMIA AND ELEVATED LEVELS OF PARATHYROID HORMONE-RELATED PROTEIN IN CUTANEOUS SQUAMOUS BASAL-CELL CARCINOMA SO JOURNAL OF INTERNAL MEDICINE LA English DT Article DE HYPERCALCEMIA; PTH-RP; SQUAMOUS CELL CARCINOMA ID MALIGNANCY-ASSOCIATED HYPERCALCEMIA; HUMORAL HYPERCALCEMIA; PEPTIDE AB A patient with mixed squamous/basal cell carcinoma of the skin presented with hypercalcaemia and elevated serum levels of Parathyroid hormone-related protein (PTH-rP). The tumour was resected, PTH-rP levels declined and the patient became normocalcaemic. This is the first case to associate squamous cell carcinoma of the skin with hypercalcaemia and significant levels of PTH-rP. C1 USA STAFF,FITZSIMONS ARMY MED CTR,ENDOCRINE SERV,AURORA,CO 80045. WALTER REED ARMY INST RES,DEPT PHARMACOL,WASHINGTON,DC 20307. VET ADM MED CTR,ENDOCRINE UNIT,SAN FRANCISCO,CA 94121. UNIV CALIF SAN FRANCISCO,SAN FRANCISCO,CA 94143. EISENHOWER ARMY MED CTR,DEPT FAMILY PRACTICE,FT GORDON,GA. FU NCI NIH HHS [5 R01 CA34738]; NIDDK NIH HHS [2 R01 DK35323] NR 11 TC 10 Z9 10 U1 0 U2 0 PU BLACKWELL SCIENCE LTD PI OXFORD PA OSNEY MEAD, OXFORD, OXON, ENGLAND OX2 0EL SN 0954-6820 J9 J INTERN MED JI J. Intern. Med. PD FEB PY 1993 VL 233 IS 2 BP 205 EP 207 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA KN317 UT WOS:A1993KN31700017 PM 8433083 ER PT J AU XIAO, SY DIGLISIC, G AVSICZUPANC, T LEDUC, JW AF XIAO, SY DIGLISIC, G AVSICZUPANC, T LEDUC, JW TI DOBRAVA VIRUS AS A NEW HANTAVIRUS - EVIDENCED BY COMPARATIVE SEQUENCE-ANALYSIS SO JOURNAL OF MEDICAL VIROLOGY LA English DT Article DE HANTAAN VIRUS; HEMORRHAGIC FEVER WITH RENAL SYNDROME; SLOVENIA; NUCLEOTIDE SEQUENCE; RT-PCR ID HEMORRHAGIC-FEVER; MOLECULAR CHARACTERIZATION; NUCLEOTIDE-SEQUENCE; RENAL SYNDROME; HANTAAN VIRUS; SEGMENT; RNA; GENOME AB Dobrava virus, recently isolated from a yellow-neck mouse (Apodemus flavicollis), captured in a northern Slovenian village where severe cases of hemorrhagic fever with renal syndrome were recognized, was shown by serology and restriction enzyme digestion of PCR-amplified gene segments to be related to previously recognized hantaviruses. To investigate further the relationship of this new isolate to other hantaviruses, a portion of the medium (M) genome segment of Dobrava virus was amplified by PCR and the nucleotide sequence determined. Comparing the nucleotide sequence with the same gene region of other hantaviruses revealed an overall homology of 41.7%. A phylogenetic tree based on pairwise sequence similarity clearly showed that Dobrava virus is genetically distinct, and probably represents a new virus in the genus Hantavirus of the family Bunyaviridae. C1 UNIV LJUBLJANA,INST MICROBIOL,YU-61105 LJUBLJANA,SLOVENIA. RP XIAO, SY (reprint author), USA,MED RES INST INFECT DIS,DIV DIS ASSESSMENT,BLDG 1425,FT DETRICK,FREDERICK,MD 21702, USA. RI Xiao, Shu-Yuan/E-2215-2012 NR 17 TC 16 Z9 19 U1 0 U2 1 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0146-6615 J9 J MED VIROL JI J. Med. Virol. PD FEB PY 1993 VL 39 IS 2 BP 152 EP 155 DI 10.1002/jmv.1890390212 PG 4 WC Virology SC Virology GA KM434 UT WOS:A1993KM43400011 PM 8487037 ER PT J AU ROBERTSON, FM OLSEN, SB JACKSON, MR ROCHON, RB AF ROBERTSON, FM OLSEN, SB JACKSON, MR ROCHON, RB TI INGUINAL-SCROTAL SUPPURATION FOLLOWING TREATMENT OF PERFORATED APPENDICITIS SO JOURNAL OF PEDIATRIC SURGERY LA English DT Article DE APPENDICITIS, PERFORATED; INGUINAL HERNIA; COMMUNICATING HYDROCELE; INGUINAL-SCROTAL SUPPURATION ID CHILDREN RP ROBERTSON, FM (reprint author), BROOKE ARMY MED CTR,GEN SURG SERV,DEPT SURG,MED CORPS,FT SAM HOUSTON,TX 78234, USA. NR 9 TC 6 Z9 6 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0022-3468 J9 J PEDIATR SURG JI J. Pediatr. Surg. PD FEB PY 1993 VL 28 IS 2 BP 267 EP 268 DI 10.1016/S0022-3468(05)80292-1 PG 2 WC Pediatrics; Surgery SC Pediatrics; Surgery GA KM707 UT WOS:A1993KM70700038 PM 8437094 ER PT J AU DOSAKAAKITA, K TORTELLA, FC HOLADAY, JW LONG, JB AF DOSAKAAKITA, K TORTELLA, FC HOLADAY, JW LONG, JB TI THE KAPPA OPIOID AGONIST U-50,488H ANTAGONIZES RESPIRATORY EFFECTS OF MU OPIOID RECEPTOR AGONISTS IN CONSCIOUS RATS SO JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS LA English DT Article ID INDUCED ANALGESIA; DEPRESSION; MORPHINE; OPIATE; DYNORPHIN; NALOXONE; INVIVO AB The interactive effects of mu and kappa opioid receptor agonists on respiratory function were investigated following their i.c.v. injection into conscious rats. The highly selective mu receptor agonist [D-Ala2,N-Methyl-Phe4,Gly-ol] enkephalin (DAMGO; 1.2-10 nmol) and the relatively selective mu agonist morphine (20 and 30 nmol) significantly decreased arterial pH and PO2, and increased arterial PCO2 and blood pressure. Morphine and a low dose of DAMGO (1.2 nmol) also significantly elevated respiratory rate. Heart rate was decreased by DAMGO and, depending upon dose, was either decreased (20 nmol) or increased (30 nmol) by morphine. The selective kappa opioid agonist U-50,488H (200 nmol i.c.v.), which by itself had no significant effect on either respiration or cardiovascular function, dose-dependently antagonized the acidotic, hypoxemic and hypercapnic effects of both DAMGO (2.5 nmol) and morphine (30 nmol). Furthermore, these mu antagonistic properties of U-50,488H were blocked completely after pretreatment with 25 nmol of the highly selective kappa opioid antagonist nor-binaltorphimine. These results indicate that the antagonism of mu opioid respiratory depressant effects by U-50,488H is kappa opioid receptor mediated. C1 WALTER REED ARMY INST RES,DEPT MED NEUROSCI,NEUROPHARMACOL BRANCH,WASHINGTON,DC 20307. HOKKAIDO UNIV,SCH MED,DEPT MED 1,KITA KU,SAPPORO,HOKKAIDO 060,JAPAN. ENTREMED INC,NEW YORK,NY. NR 24 TC 37 Z9 37 U1 0 U2 5 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-3565 J9 J PHARMACOL EXP THER JI J. Pharmacol. Exp. Ther. PD FEB PY 1993 VL 264 IS 2 BP 631 EP 637 PG 7 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA KM432 UT WOS:A1993KM43200016 PM 8382278 ER PT J AU TAKAHASHI, T MILLER, P CHEN, YM SAMUELSON, L GALOTTI, D MANDAL, BK KUMAR, J TRIPATHY, SK AF TAKAHASHI, T MILLER, P CHEN, YM SAMUELSON, L GALOTTI, D MANDAL, BK KUMAR, J TRIPATHY, SK TI LANGMUIR-BLODGETT-FILMS OF POLYMETHACRYLATES WITH SIDE-CHAINS CONTAINING FUNCTIONALIZED AROMATIC SCHIFF-BASES SO JOURNAL OF POLYMER SCIENCE PART B-POLYMER PHYSICS LA English DT Article DE LANGMUIR-BLODGETT FILM FORMATION BY POLYMETHACRYLATES WITH NONLINEAR OPTICAL SIDE CHAINS; POLYMETHACRYLATE FILMS BY LANGMUIR-BLODGETT TECHNIQUE, CONFIGURATION OF NONLINEAR OPTICAL SUBSTITUENTS IN; ORIENTATION OF NONLINEAR OPTICAL MOIETIES IN LANGMUIR-BLODGETT FILMS OF SUBSTITUTED POLYMETHACRYLATES ID 2ND HARMONIC-GENERATION; 2ND-HARMONIC GENERATION; MULTILAYERS; HEMICYANINE; MONOLAYERS; POLYMER; ACID; DYE AB Langmuir-Blodgett (LB) film formation has been investigated for polymers in which nonlinear optical (NLO) moieties are attached to the side chain of a polymethacrylate (PMA) backbone. Polymer monolayers were successfully transferred onto hydrophilic glass substrates using a moving-wall type LB trough. The LB films were characterized by pressure-area isotherms, polarized ultraviolet visible spectra, ellipsometry, and second harmonic generation measurements. The characterization shows that NLO moieties in the side chain are inclined at a shallow angle to the plane of the substrate. The second-order nonlinear optical coefficient and molecular hyperpolarizability were also calculated. C1 UNIV MASSACHUSETTS,DEPT CHEM,LOWELL,MA 01854. UNIV MASSACHUSETTS,DEPT PHYS,LOWELL,MA 01854. USA,DIV BIOTECHNOL,NATICK RD&E CTR,NATICK,MA 01760. RP TAKAHASHI, T (reprint author), SEKISUI CHEM CO LTD,TSUKUBA,JAPAN. NR 28 TC 18 Z9 18 U1 0 U2 4 PU JOHN WILEY & SONS INC PI NEW YORK PA 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0887-6266 J9 J POLYM SCI POL PHYS JI J. Polym. Sci. Pt. B-Polym. Phys. PD FEB PY 1993 VL 31 IS 2 BP 165 EP 173 DI 10.1002/polb.1993.090310205 PG 9 WC Polymer Science SC Polymer Science GA KG486 UT WOS:A1993KG48600005 ER PT J AU TOOTHAKER, RW NAGY, WW AF TOOTHAKER, RW NAGY, WW TI PROTECTION OF RECENT EXTRACTION SITES WHEN FABRICATING IMMEDIATE ACRYLIC INTERIM FIXED RESTORATIONS SO JOURNAL OF PROSTHETIC DENTISTRY LA English DT Article AB Protection of all soft tissues is an early and integral component of the total treatment plan involving any dental restoration. A procedure is presented to provide protection of recent extraction sites by using adhesive Burlew foil when making an immediate fixed restoration. The foil provides protection, at the extraction site, from both mechanical and chemical irritation. RP TOOTHAKER, RW (reprint author), USA,ADV PROSTHODONT RESIDENCY,FT RUCKER,AL 36362, USA. NR 8 TC 1 Z9 1 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0022-3913 J9 J PROSTHET DENT JI J. Prosthet. Dent. PD FEB PY 1993 VL 69 IS 2 BP 232 EP 233 DI 10.1016/0022-3913(93)90146-F PG 2 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA KJ598 UT WOS:A1993KJ59800019 PM 8429517 ER PT J AU MENDOZA, JA GRANT, E HOROWITZ, PM AF MENDOZA, JA GRANT, E HOROWITZ, PM TI PARTIALLY FOLDED RHODANESE OR ITS N-TERMINAL SEQUENCE CAN DISRUPT PHOSPHOLIPID-VESICLES SO JOURNAL OF PROTEIN CHEMISTRY LA English DT Article DE PHOSPHOLIPID VESICLES; RHODANESE; FOLDING; PEPTIDES; LEADER SEQUENCE ID PRECURSOR PROTEIN; MITOCHONDRIAL PROTEIN; MEMBRANE; PEPTIDES; IMPORT AB Rhodanese (thiosulfate cyanide sulfurtransferase; E.C. 2.8.1.1) is a mitochondrial enzyme that is unprocessed after import. We describe in vitro experiments showing that partially folded rhodanese can interact with lipid bilayers. The interaction was monitored by measuring the ability of rhodanese to disrupt small unilamellar vesicles composed of phosphatidylserine and to release 6-carboxyfluorescein that was trapped in the liposomes. Partially folded rhodanese, derived by dilution of urea-unfolded enzyme, efficiently induced liposome leakage. Native rhodanese had no effect on liposome integrity. Liposome disruption progressively decreased as rhodanese was given the opportunity to refold or aggregate before introduction of the liposomes. A synthetic 23 amino acid peptide representing the N-terminal sequence of rhodanese was very efficient at disrupting the liposomes. Shorter peptides chosen from within this sequence (residues 11-23 or residues 1-17) had no effect on liposome disruption. A peptide representing the tether region that connects the domains of the enzyme was also without effect. These results are consistent with the hypothesis that the N-terminal sequence of rhodanese is an uncleaved leader sequence, and can interact with membrane components that are involved in the mitochondrial uptake of this protein. C1 UNIV TEXAS,HLTH SCI CTR,DEPT BIOCHEM,SAN ANTONIO,TX 78284. BROOKE ARMY MED CTR,DEPT CLIN INVEST,FT SAM HOUSTON,TX 78234. FU NIEHS NIH HHS [ES05729]; NIGMS NIH HHS [GM25177] NR 29 TC 4 Z9 4 U1 0 U2 0 PU PLENUM PUBL CORP PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 SN 0277-8033 J9 J PROTEIN CHEM JI J. Protein Chem. PD FEB PY 1993 VL 12 IS 1 BP 65 EP 69 DI 10.1007/BF01024916 PG 5 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA KH752 UT WOS:A1993KH75200011 PM 8427635 ER PT J AU SMITH, KJ SKELTON, HG YEAGER, J BAXTER, D ANGRITT, P JOHNSON, S OSTER, CN WAGNER, KF AF SMITH, KJ SKELTON, HG YEAGER, J BAXTER, D ANGRITT, P JOHNSON, S OSTER, CN WAGNER, KF TI CLINICAL-FEATURES OF INFLAMMATORY DERMATOSES IN HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 DISEASE AND THEIR CORRELATION WITH WALTER-REED STAGE SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Article ID SELECTIVE LOSS; DEFICIENCY; INDIVIDUALS; DERMATITIS; ANTIBODIES; INFECTION; RESPONSES; AIDS AB Background: As part of a military study of the natural history of human immunodeficiency virus type 1 (HIV-1) disease, all patients entered in the study were examined for cutaneous changes associated with HIV-1 infection. Objective: Our purpose was to characterize and record the types of inflammatory dermatoses in a large number of HIV-1-infected patients to determine whether there was a correlation with the stage of disease. Methods: The clinical findings in each case were compared with the results of cultures and biopsy specimens and correlated with Walter Reed stage. Results: Most of the inflammatory dermatoses were maculopapular eruptions often with prominent follicular involvement, and in some there was a lichenoid component. With increasing Walter Reed stage, many eruptions become papulosquamous, some with psoriasiform scale and some with a hypertrophic lichenoid appearance. Conclusion: Although most of the inflammatory eruptions were nonspecific clinically, most cases showed features resembling those in graft-versus-host disease. C1 ARMED FORCES INST PATHOL, DEPT DERMATOPATHOL, WASHINGTON, DC 20306 USA. NATL NAVAL MED CTR, AIDS REGISTRY, BETHESDA, MD 20814 USA. HENRY M JACKSON FDN, WASHINGTON, DC USA. NATL NAVAL MED CTR, DEPT DERMATOL, BETHESDA, MD 20814 USA. WALTER REED ARMY MED CTR, INFECT DIS SERV, WASHINGTON, DC 20307 USA. WALTER REED ARMY INST RES, WASHINGTON, DC 20307 USA. FU NIAMS NIH HHS [YOIAR00014, YOIAR90008] NR 16 TC 15 Z9 15 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD FEB PY 1993 VL 28 IS 2 BP 167 EP 173 DI 10.1016/0190-9622(93)70023-M PN 1 PG 7 WC Dermatology SC Dermatology GA KL341 UT WOS:A1993KL34100002 PM 8432912 ER PT J AU SMITH, KJ SKELTON, HG YEAGER, J ANGRITT, P FRISMAN, D WAGNER, KF BAXTER, D JAMES, WD OSTER, CN AF SMITH, KJ SKELTON, HG YEAGER, J ANGRITT, P FRISMAN, D WAGNER, KF BAXTER, D JAMES, WD OSTER, CN TI HISTOPATHOLOGIC AND IMMUNOHISTOCHEMICAL FINDINGS ASSOCIATED WITH INFLAMMATORY DERMATOSES IN HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 DISEASE AND THEIR CORRELATION WITH WALTER-REED STAGE SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Article ID HOST-DISEASE; HOMOSEXUAL MEN; SELECTIVE LOSS; HIV INFECTION; LYMPHOCYTE-T; GRAFT; CELL; DEFICIENCY; AIDS; SKIN AB Background: Cutaneous lesions are common in patients with human immunodeficiency virus type 1 (HIV-1) infection. In many cases they are nonspecific inflammatory dermatoses. Objective. Our goal was to determine whether features of these inflammatory dermatoses were characteristic of HIV-1 infection and whether the changes correlated with the stage of disease. Methods: Biopsy specimens of inflammatory dermatoses from 176 HIV-1-infected patients in all Walter Reed stages were reviewed and the changes were compared with each WR stage. Results. The changes found were nonspecific but were suggestive of features described in graft-versus-host disease and became more prominent in late-stage disease. Conclusion: A correlation was found between the changes and the stage of disease, and the findings add support to prior reports that at least some of the changes in HIV-1 infection may be autoimmune in origin. C1 ARMED FORCES INST PATHOL, DEPT DERMATOPATHOL, WASHINGTON, DC 20306 USA. HENRY M JACKSON FDN, DEPT DERMATOL, WASHINGTON, DC USA. NATL NAVAL MED CTR, AIDS REGISTRY, BETHESDA, MD 20814 USA. NATL NAVAL MED CTR, DEPT CELLULAR PATHOL, BETHESDA, MD 20814 USA. WALTER REED ARMY INST RES, WASHINGTON, DC 20307 USA. WALTER REED ARMY MED CTR, DEPT MED, DERMATOL SERV, WASHINGTON, DC 20307 USA. WALTER REED ARMY MED CTR, INFECT DIS SERV, WASHINGTON, DC 20307 USA. FU NIAMS NIH HHS [YOIAR00014, YOIAR90008] NR 47 TC 15 Z9 15 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD FEB PY 1993 VL 28 IS 2 BP 174 EP 184 DI 10.1016/0190-9622(93)70024-N PN 1 PG 11 WC Dermatology SC Dermatology GA KL341 UT WOS:A1993KL34100003 PM 8432913 ER PT J AU HEIMER, WL JAMES, WD AF HEIMER, WL JAMES, WD TI DERMATOPATHIA-PIGMENTOSA-RETICULARIS - REPLY SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Letter RP HEIMER, WL (reprint author), WALTER REED ARMY MED CTR,DERMATOL SERV,WASHINGTON,DC 20307, USA. NR 10 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD FEB PY 1993 VL 28 IS 2 BP 279 EP 280 DI 10.1016/S0190-9622(08)81161-9 PN 1 PG 2 WC Dermatology SC Dermatology GA KL341 UT WOS:A1993KL34100032 ER PT J AU REEBER, RR WIEDERHORN, SM AF REEBER, RR WIEDERHORN, SM TI SYMPOSIUM FOR SURFACE ENGINEERING OF STRUCTURAL CERAMICS SO JOURNAL OF THE AMERICAN CERAMIC SOCIETY LA English DT Editorial Material C1 NATL INST STAND & TECHNOL,GAITHERSBURG,MD 20899. RP REEBER, RR (reprint author), USA,RES OFF,RES TRIANGLE PK,NC 27709, USA. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER CERAMIC SOC PI WESTERVILLE PA 735 CERAMIC PLACE, PO BOX 6136, WESTERVILLE, OH 43081-6136 SN 0002-7820 J9 J AM CERAM SOC JI J. Am. Ceram. Soc. PD FEB PY 1993 VL 76 IS 2 BP 260 EP 260 DI 10.1111/j.1151-2916.1993.tb03776.x PG 1 WC Materials Science, Ceramics SC Materials Science GA LE277 UT WOS:A1993LE27700001 ER PT J AU REEBER, RR AF REEBER, RR TI SURFACE ENGINEERING OF STRUCTURAL CERAMICS SO JOURNAL OF THE AMERICAN CERAMIC SOCIETY LA English DT Review ID ION-IMPLANTATION; ROOM-TEMPERATURE; SLIDING FRICTION; WEAR; STRESSES; METAL; IRRADIATION; DEPOSITION; TOUGHNESS; OXIDATION AB The role of surface engineering for controlling structural ceramic properties is reviewed. initially, a perspective of the effects of an unmodified surface state on fracture, adhesion, tribological properties, and degradation is given. Ceramic surface modification techniques including laser, ion, ion-beam-assisted deposition, and plasma-assisted deposition are then discussed with regard to how each non-equilibrium technique affects bulk and surface properties. The importance of experiments, process and materials characterization, and modeling for understanding changes in localized bonding, chemistry, and structure is emphasized. Although not exhaustive, a broad guide to important literature is given. RP USA, RES OFF, RES TRIANGLE PK, NC 27709 USA. NR 104 TC 12 Z9 12 U1 1 U2 4 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0002-7820 EI 1551-2916 J9 J AM CERAM SOC JI J. Am. Ceram. Soc. PD FEB PY 1993 VL 76 IS 2 BP 261 EP 268 DI 10.1111/j.1151-2916.1993.tb03777.x PG 8 WC Materials Science, Ceramics SC Materials Science GA LE277 UT WOS:A1993LE27700002 ER PT J AU HOWARD, SL NEWBERRY, JE SAUSA, RC MIZIOLEK, AW AF HOWARD, SL NEWBERRY, JE SAUSA, RC MIZIOLEK, AW TI TRIPLE QUADRUPOLE MASS-SPECTROMETRY AS APPLIED TO FLAME DIAGNOSTICS - STUDY OF THE C2H4/N2O/AR FLAME SO JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY LA English DT Article ID HYDROGEN; LAMINAR; OXYGEN AB A recently developed research apparatus for characterization of low-pressure premixed flames has been developed and was used to characterize the C2H4/N2O/Ar flame at 20 torr. This instrument incorporates several diagnostic techniques in one apparatus so that individual techniques can be quantitatively compared and the usable detection range (both in terms of resolution and species detection) expanded. Results discussed in this report include mass analysis by triple quadrupole mass spectrometer and temperature measurement by thermocouple. Concentration profiles in the one-dimensional flame include CO, N2, and C2H4 at nominal m/z 28 as well as CO2 and N2O at m/z 44. C1 USA,RES LAB,ABERDEEN PROVING GROUND,MD 21010. NR 21 TC 1 Z9 1 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 1044-0305 J9 J AM SOC MASS SPECTR JI J. Am. Soc. Mass Spectrom. PD FEB PY 1993 VL 4 IS 2 BP 152 EP 158 DI 10.1016/1044-0305(93)85071-5 PG 7 WC Chemistry, Analytical; Chemistry, Physical; Spectroscopy SC Chemistry; Spectroscopy GA KM118 UT WOS:A1993KM11800009 PM 24234794 ER PT J AU BOWDEN, CM DOWLING, JP EVERITT, HO AF BOWDEN, CM DOWLING, JP EVERITT, HO TI DEVELOPMENT AND APPLICATIONS OF MATERIALS EXHIBITING PHOTONIC BAND-GAPS - INTRODUCTION SO JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICS LA English DT Editorial Material C1 USA,RES OFF,RES TRIANGLE PK,NC 27709. RP BOWDEN, CM (reprint author), USA,MISSILE COMMAND,CTR RES DEV & ENGN,AMSMI RD WS ST,WEAP SCI DIRECTORATE,REDSTONE ARSENAL,AL 35898, USA. RI DOWLING, JONATHAN/L-2749-2013; Everitt, Henry/L-7118-2013 OI Everitt, Henry/0000-0002-8141-3768 NR 1 TC 85 Z9 85 U1 0 U2 4 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0740-3224 J9 J OPT SOC AM B JI J. Opt. Soc. Am. B-Opt. Phys. PD FEB PY 1993 VL 10 IS 2 BP 280 EP 280 PG 1 WC Optics SC Optics GA KK745 UT WOS:A1993KK74500013 ER PT J AU DOWLING, JP BOWDEN, CM AF DOWLING, JP BOWDEN, CM TI BEAT RADIATION FROM DIPOLES NEAR A PHOTONIC BAND EDGE SO JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICS LA English DT Article ID INHIBITED SPONTANEOUS EMISSION; QUANTUM ELECTRODYNAMICS; DIELECTRIC MEDIA; OPTICS; ATOMS AB We consider a model for two nearly identical, slightly detuned dipoles that radiate in frequency near a photonic band edge such that one dipole is in the band while the other is in the gap. The dipole in the gap does not radiate directly, but its presence can be detected by beats that occur in the power output of the dipole that is in the band. Hence it is possible to detect properties of and perhaps to excite gap dipoles if they are coupled by local modes to dipoles that are located in the frequency band. RP DOWLING, JP (reprint author), USA,MISSILE COMMAND,CTR RES DEV & ENGN,AMSMI-RD-WS-ST,WEAP SCI DIRECTORATE,REDSTONE ARSENAL,AL 35898, USA. RI DOWLING, JONATHAN/L-2749-2013 NR 22 TC 18 Z9 18 U1 0 U2 0 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0740-3224 J9 J OPT SOC AM B JI J. Opt. Soc. Am. B-Opt. Phys. PD FEB PY 1993 VL 10 IS 2 BP 353 EP 355 DI 10.1364/JOSAB.10.000353 PG 3 WC Optics SC Optics GA KK745 UT WOS:A1993KK74500024 ER EF