FN Thomson Reuters Web of Science™ VR 1.0 PT J AU NWAGWU, M HAYNES, JD ORLANDI, PA CHULAY, JD AF NWAGWU, M HAYNES, JD ORLANDI, PA CHULAY, JD TI PLASMODIUM-FALCIPARUM - CHYMOTRYPTIC-LIKE PROTEOLYSIS ASSOCIATED WITH A 101-KDA ACIDIC BASIC REPEAT ANTIGEN SO EXPERIMENTAL PARASITOLOGY LA English DT Article DE PLASMODIUM-FALCIPARUM; MALARIA; ANTIGENS; VACCINE CANDIDATE ANTIGEN; PROTEINASE, PROTEASE, PROTEOLYSIS, OR ENDOPEPTIDASE; AMINOPEPTIDASE; PURIFICATION; ENZYME OVERLAY MEMBRANES; NT BUFFER (20 MM NACL, 100 MM TRIS-HCL, PH 7.0) ID MONOCLONAL-ANTIBODY CHARACTERIZATION; ERYTHROCYTE INVASION; PROTEASE INHIBITORS; POLYACRYLAMIDE GELS; MEROZOITE SURFACE; IMMUNE SERUM; SCHIZONTS MATURE; IDENTIFICATION; PROTEINASE; PURIFICATION C1 WALTER REED ARMY INST RES,DEPT IMMUNOL,WASHINGTON,DC 20307. NR 50 TC 26 Z9 26 U1 0 U2 0 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0014-4894 J9 EXP PARASITOL JI Exp. Parasitol. PD DEC PY 1992 VL 75 IS 4 BP 399 EP 414 DI 10.1016/0014-4894(92)90253-7 PG 16 WC Parasitology SC Parasitology GA KF085 UT WOS:A1992KF08500004 PM 1493872 ER PT J AU LUNARDINI, VJ AF LUNARDINI, VJ TI AN ANALYTICAL STUDY OF A 2-LAYER TRANSIENT THERMAL CONDUCTION PROBLEM AS APPLIED TO SOIL-TEMPERATURE SURVEYS - DISCUSSION SO GEOPHYSICS LA English DT Discussion RP LUNARDINI, VJ (reprint author), USA,COLD REG RES & ENGN LAB,CORPS ENGINEERS,HANOVER,NH 03755, USA. NR 3 TC 0 Z9 0 U1 0 U2 0 PU SOC EXPLORATION GEOPHYSICISTS PI TULSA PA 8801 S YALE ST, TULSA, OK 74137 SN 0016-8033 J9 GEOPHYSICS JI Geophysics PD DEC PY 1992 VL 57 IS 12 BP 1644 EP 1645 DI 10.1190/1.1443232 PG 2 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA KB689 UT WOS:A1992KB68900014 ER PT J AU SCHROEDER, RE ACKER, BJ SCHELL, MG TROYER, JE WHITAKER, NK AF SCHROEDER, RE ACKER, BJ SCHELL, MG TROYER, JE WHITAKER, NK TI ECONOMIC GRAND ROUNDS - A FORUM FOR COST CONSCIOUSNESS SO HOSPITAL & HEALTH SERVICES ADMINISTRATION LA English DT Article AB This article analyzes the implementation of a traditional Economic Grand Rounds (EGR) program in a teaching hospital. The conclusions are that the original concepts of EGR-presentations of treatment costs by clinicians in a grand rounds setting, reinforcement of agreed changes in practice patterns, and subsequent evaluation and participation-are still valid but are inadequate to ensure a successful program. Other factors must be added if EGR is to attain its goals. These factors are administrative and nursing involvement, a provision to make policy changes, and incentives for the medical staff. This article also outlines areas of potential savings achieved through an EGR program in laboratory testing, preoperative laboratory testing, and intravenous therapy with antibiotics. C1 USAF MALCOLM GROW MED CTR,CAMP SPRINGS,MD. USAF,PLATTSBURGH AFB,NY. WILFORD HALL USAF MED CTR,LACKLAND AFB,TX 78236. BRADY GREEN COMMUNITY CLIN,SAN ANTONIO,TX. RP SCHROEDER, RE (reprint author), USA,GRAD PROGRAM HLTH CARE ADM,FT SAM HOUSTON,TX 78234, USA. NR 18 TC 0 Z9 0 U1 0 U2 0 PU AMER COLL HEALTHCARE EXEC HEALTH ADMINISTRATION PRESS PI CHICAGO PA ONE NORTH FRANKLIN ST SUITE 1700, CHICAGO, IL 60606 SN 8750-3735 J9 HOSP HEALTH SERV ADM JI Hosp. Health Serv. Adm. PD WIN PY 1992 VL 37 IS 4 BP 491 EP 502 PG 12 WC Health Policy & Services SC Health Care Sciences & Services GA JX377 UT WOS:A1992JX37700006 PM 10171277 ER PT J AU MCHUGH, P AF MCHUGH, P TI A D-AND-T SPECIAL REPORT - IEEE-P1149.5 MODULE TEST AND MAINTENANCE BUS SO IEEE DESIGN & TEST OF COMPUTERS LA English DT Article RP MCHUGH, P (reprint author), USA,RES LAB,AMSRL,EP,RA,FT MONMOUTH,NJ 07703, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1264 SN 0740-7475 J9 IEEE DES TEST COMPUT JI IEEE Des. Test Comput. PD DEC PY 1992 VL 9 IS 4 BP 62 EP 65 DI 10.1109/54.173335 PG 4 WC Computer Science, Hardware & Architecture; Engineering, Electrical & Electronic SC Computer Science; Engineering GA KA361 UT WOS:A1992KA36100009 ER PT J AU PENNISE, CA BOESCH, HE AF PENNISE, CA BOESCH, HE TI PHOTOCONDUCTION MEASUREMENTS OF THE CHARGE TRAPPING AND TRANSPORT IN BOND-AND-ETCH-BACK BURIED OXIDES SO IEEE TRANSACTIONS ON NUCLEAR SCIENCE LA English DT Article; Proceedings Paper CT 29TH IEEE ANNUAL INTERNATIONAL NUCLEAR AND SPACE RADIATION EFFECTS CONF AND SHORT COURSE CY JUL 13-17, 1992 CL NEW ORLEANS, LA SP IEEE, RADIAT EFFECTS COMM ID SILICON-ON-INSULATOR; X-RAY; CO-60 AB The charge trapping and transport characteristics of bond-and-etch-back buried oxides (BESOI) have been investigated using a photoconduction current technique and total dose capacitance-voltage (C-V) shift measurements. Results obtained from these materials are compared to results previously obtained on standard SIMOX (separation by implantation of oxygen) materials. The photocurrent experiment was also performed on thermally grown oxides with an oxide layer similar in thickness to the BESOI and SIMOX material used in this study. Measurements were performed on the thermal oxides as a method of calibration for both the experimental and analytical methods that are applied to the photoconduction current technique. We measure large normalized photoconduction currents and large postirradiation mid-gap voltage shifts in the BESOI material. Taken together, these results indicate most of the electrons and the holes move through the BESOI oxide and a significant fraction of the holes are trapped at the interfaces. These radiation response characteristics are also typical of non-radiation-hardened thermal oxides and this leads us to further conclude that techniques used to successfully harden thermal oxides may also bc successful when applied to BESOI material. RP PENNISE, CA (reprint author), USA,RES LAB,2800 POWDER MILL RD,ADELPHI,MD 20783, USA. NR 10 TC 3 Z9 3 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9499 J9 IEEE T NUCL SCI JI IEEE Trans. Nucl. Sci. PD DEC PY 1992 VL 39 IS 6 BP 2139 EP 2145 DI 10.1109/23.211414 PN 1 PG 7 WC Engineering, Electrical & Electronic; Nuclear Science & Technology SC Engineering; Nuclear Science & Technology GA KM885 UT WOS:A1992KM88500077 ER PT J AU LELIS, AJ OLDHAM, TR AF LELIS, AJ OLDHAM, TR TI X-RAY-LITHOGRAPHY EFFECTS ON MOS OXIDES SO IEEE TRANSACTIONS ON NUCLEAR SCIENCE LA English DT Article; Proceedings Paper CT 29TH IEEE ANNUAL INTERNATIONAL NUCLEAR AND SPACE RADIATION EFFECTS CONF AND SHORT COURSE CY JUL 13-17, 1992 CL NEW ORLEANS, LA SP IEEE, RADIAT EFFECTS COMM ID N-CHANNEL IGFETS; HOT-CARRIER; INDUCED INSTABILITY; RADIATION-DAMAGE; SILICON DIOXIDE; TRAPPED HOLES; SIO2; GENERATION; TRANSISTORS; CAPACITORS AB N- and p-channel MOSFETs were subjected to hot-carrier injection to compare the reliability of devices with and without exposure to simulated x-ray lithography. No significant electrical effects due to hot-carrier injection under realistic operating conditions were observed. This result suggests that neutral electron trap charging may not be as serious a problem as has been previously thought. RP LELIS, AJ (reprint author), USA,RES LAB,ADELPHI,MD 20783, USA. NR 42 TC 6 Z9 6 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9499 J9 IEEE T NUCL SCI JI IEEE Trans. Nucl. Sci. PD DEC PY 1992 VL 39 IS 6 BP 2204 EP 2210 DI 10.1109/23.211422 PN 1 PG 7 WC Engineering, Electrical & Electronic; Nuclear Science & Technology SC Engineering; Nuclear Science & Technology GA KM885 UT WOS:A1992KM88500085 ER PT J AU AKKARA, JA SALAPU, P KAPLAN, DL AF AKKARA, JA SALAPU, P KAPLAN, DL TI CHARACTERIZATION OF POLYANILINE SYNTHESIZED BY ENZYME-CATALYZED REACTIONS IN ORGANIC-SOLVENTS SO INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY LA English DT Article; Proceedings Paper CT INTERNATIONAL SYMP ON ENZYMES IN ORGANIC SYNTHESIS CY JAN 06-09, 1992 CL NEW DELHI, INDIA SP INT UNION PURE & APPL CHEM ID FILMS AB Earlier studies have shown that properties of chemically synthesized polyaniline could be modified by the type of synthesis - electrochemical, chemical or potential cycling. A new enzymatic approach for the synthesis of polyaniline by the polymerization of aniline with hydrogen peroxide catalyzed by horse-radish peroxidase in organic solvents with different amounts of water is reported. The polymer synthesized has been isolated and characterized for thermal properties, functional groups and structure. Thermal analyses indicate that the polyaniline synthesized has relatively good thermal stability with about 30 to 50% residue remaining after thermal treatment up to 600-degrees-C in an atmosphere of nitrogen. FTIR, C-13-NMR and H-1-NMR spectra have indicated at least two possible structurally different polyaniline products, one consisting of alternating benzoid-quinoid structure and the other ortho- and para-substituted carbon-carbon and carbon-nitrogen bond structures. RP AKKARA, JA (reprint author), USA,NATICK RES & DEV LABS,CTR DEV & ENGN,DIV BIOTECHNOL,NATICK,MA 01760, USA. NR 16 TC 21 Z9 22 U1 0 U2 6 PU COUNCIL SCIENTIFIC INDUSTRIAL RESEARCH PI NEW DELHI PA PUBL & INFO DIRECTORATE, NEW DELHI 110012, INDIA SN 0376-4699 J9 INDIAN J CHEM B JI Indian J. Chem. Sect B-Org. Chem. Incl. Med. Chem. PD DEC PY 1992 VL 31 IS 12 BP 855 EP 858 PG 4 WC Chemistry, Organic SC Chemistry GA KA364 UT WOS:A1992KA36400014 ER PT J AU SHABANA, AA HWANG, YL WEHAGE, RA AF SHABANA, AA HWANG, YL WEHAGE, RA TI PROJECTION METHODS IN FLEXIBLE MULTIBODY DYNAMICS .1. KINEMATICS SO INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN ENGINEERING LA English DT Article ID RECURSIVE FORMULATION; LOOP SYSTEMS AB In this paper a recursive projection method for the dynamic analysis of open-loop mechanical systems that consist of a set of interconnected deformable bodies is presented. The configuration of each body in the system is identified using a coupled set of reference and elastic co-ordinates. The absolute velocities and accelerations of leaf or child bodies in the open-loop system are expressed in terms of the absolute velocities and accelerations of the parent bodies and the time derivatives of the relative co-ordinates of the joints between the bodies. The dynamic differential equations of motion are developed for each link using the generalized Newton-Euler equations. The relationship between the actual joint reactions and the generalized forces combined with the kinematic relationships and the generalized Newton-Euler equations are used to develop a system of loosely coupled equations which has a sparse matrix structure. Using matrix partitioning and recursive projection techniques based on optimal block factorization, an efficient solution for the system accelerations and joint reaction forces is obtained. This solution technique yields a much smaller operations count and can more effectively exploit vectorization and parallel processing. It also allows a systematic procedure for decoupling the joint and elastic accelerations. C1 USA,TANK AUTOMOT COMMAND,DIV SYST SIMULAT & TECHNOL,WARREN,MI 48397. RP SHABANA, AA (reprint author), UNIV ILLINOIS,DEPT MECH ENGN,POB 4348,CHICAGO,IL 60680, USA. NR 12 TC 4 Z9 6 U1 0 U2 0 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0029-5981 J9 INT J NUMER METH ENG JI Int. J. Numer. Methods Eng. PD DEC PY 1992 VL 35 IS 10 BP 1927 EP 1939 DI 10.1002/nme.1620351002 PG 13 WC Engineering, Multidisciplinary; Mathematics, Interdisciplinary Applications SC Engineering; Mathematics GA KA701 UT WOS:A1992KA70100001 ER PT J AU WEHAGE, RA SHABANA, AA HWANG, YL AF WEHAGE, RA SHABANA, AA HWANG, YL TI PROJECTION METHODS IN FLEXIBLE MULTIBODY DYNAMICS .2. DYNAMICS AND RECURSIVE PROJECTION METHODS SO INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN ENGINEERING LA English DT Article ID BODY AB In Part I of this paper the kinematic relationships between the absolute, elastic and joint accelerations are developed. In this paper, these kinematic equations are used with the generalized Newton-Euler equations and the relationship between the actual and generalized reaction forces to develop a recursive projection algorithm for the dynamic analysis of open-loop meehanical systems consisting of a set of interconnected rigid and deformable bodies. Optimal matrix permutation, partitioning and projection methods are used to eliminate the elastic accelerations while maintaining the inertia coupling between the rigid body motion and the elastic deformation. Recursive projection methods are then applied in order to project the inertia of the leaf bodies onto their parent bodies. This leads to an optimal symbolic factorization which recursively yields the absolute and joint accelerations, and the joint reaction forces. The method presented in this paper avoids the use of Newton-Raphson algorithms in the numerical solution of the constrained dynamic equations of open-loop kinematic chains since the joint accelerations are readily available from the solution of the resulting reduced system of equations. Furthermore, the method requires only the inversion or decomposition of relatively small matrices and the numerical integration of a minimum number of co-ordinates. Open-loop multibody robotic manipulator systems are used to compare the results and efficiency of the recursive methods with that of the augmented formulations that employ Newton-Raphson algorithms. C1 UNIV ILLINOIS,DEPT MECH ENGN,CHICAGO,IL 60680. RP WEHAGE, RA (reprint author), USA,TANK AUTOMOT COMMAND,DIV SYST SIMULAT & TECHNOL,WARREN,MI 48397, USA. NR 13 TC 11 Z9 11 U1 0 U2 1 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0029-5981 J9 INT J NUMER METH ENG JI Int. J. Numer. Methods Eng. PD DEC PY 1992 VL 35 IS 10 BP 1941 EP 1966 DI 10.1002/nme.1620351003 PG 26 WC Engineering, Multidisciplinary; Mathematics, Interdisciplinary Applications SC Engineering; Mathematics GA KA701 UT WOS:A1992KA70100002 ER PT J AU MAOZ, Z ASTORINO, A AF MAOZ, Z ASTORINO, A TI WAGING WAR, WAGING PEACE - DECISION-MAKING AND BARGAINING IN THE ARAB ISRAELI CONFLICT, 1970-1973 SO INTERNATIONAL STUDIES QUARTERLY LA English DT Article; Proceedings Paper CT 1991 ANNUAL MEETING OF THE INTERNATIONAL SOC OF POLITICAL PSYCHOLOGY CY JUL, 1991 CL WASHINGTON, DC SP INT SOC POLIT PSYCHOL AB Despite many years of research on foreign policy decision making, we still lack systematic evidence on: (i) the relations between national decisions and international outcomes that take place in an interdependent environment, and (ii) the evolution of international processes over time. The study applies aspects of a Theory of International Processes (TIP) in order to shed light on the decisions and bargaining processes that took place in the Arab-Israeli conflict during the 1970-73 period. Key ingredients of TIP and some of the propositions that can be deduced from it are reviewed. Empirical measures are developed to test these propositions. We then analyze 44 key decisions made by Israel, Egypt, Jordan, Syria, the PLO, and the United States during the period. Analysis of these decisions suggests that (a) the substantive quality of decision making processes within states is related to the degree of correct perception by decision makers of the preferences and behavior of other actors, and (b) both the substantive quality of decision making processes and the degree of correct perception of other actors' preferences are correlated with the expected outcomes as well as with the optimal outcomes of those decisions. It was also found that, with the exception of Egypt, the actors involved usually relied upon ad hoc problem solving approaches and did not apply general and well-calculated strategies. Both Israel and the United States seemed to have consistently misperceived Egypt's preferences and strategy, and hence may well have missed a major opportunity to avert war in 1971-72. The implications of the approach and the findings are discussed. C1 US MIL ACAD,W POINT,NY 10996. RP MAOZ, Z (reprint author), HAIFA UNIV,DEPT POLIT SCI,HAIFA,ISRAEL. RI Maoz, Zeev/A-9844-2008 NR 45 TC 6 Z9 6 U1 0 U2 1 PU BLACKWELL PUBLISHERS PI CAMBRIDGE PA 350 MAIN STREET, STE 6, CAMBRIDGE, MA 02148-5023 SN 0020-8833 J9 INT STUD QUART JI Int. Stud. Q. PD DEC PY 1992 VL 36 IS 4 BP 373 EP 399 DI 10.2307/2600731 PG 27 WC International Relations; Political Science SC International Relations; Government & Law GA KB733 UT WOS:A1992KB73300002 ER PT J AU ROBB, ML POLONIS, V VAHEY, M GARTNER, S MICHAEL, N FOWLER, A REDFIELD, RR AF ROBB, ML POLONIS, V VAHEY, M GARTNER, S MICHAEL, N FOWLER, A REDFIELD, RR TI HIV NEUTRALIZATION ASSAY USING POLYMERASE CHAIN REACTION-DERIVED MOLECULAR SIGNALS SO JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY LA English DT Article DE HIV NEUTRALIZATION ASSAY; POLYMERASE CHAIN REACTION; POLYCLONAL ANTIBODY; DNA PROVIRUS FORMATION; IMMUNOREGULATORY MECHANISMS ID HUMAN-IMMUNODEFICIENCY-VIRUS; ANTIBODIES; INFECTION; DISEASE; INVIVO AB Characterization of the capacity of human polyclonal antibody to neutralize wild-type patient isolates has important implications for vaccine development. We report the development of a polymerase chain reaction-based neutralization assay that quantitatively measures each infection using HIV proviral formation. These molecular end points identified the absence or quantitative diminution of DNA provirus formation as well as a delay in the kinetics of HIV DNA provirus formation. Using both laboratory strain prototype isolates (HIV-1-MN, HIV-IIIb) and primary wild-type patients' isolates, neutralization end points were reproducibly determined. End points were reached within 72 h, thereby minimizing the impact of subsequent rounds of infection on interpretation of results. Although the neutralization titer of polyclonal sera was usually comparable using standard technology, this assay did find isolate-dependent variation in the relationship between p24 production and HIV proviral DNA formation. Finally, we noted the disparity between the ability of human sera to neutralize prototype and wild-type isolates in primary peripheral blood mononuclear cell targets. We believe this assay provides unique opportunities to characterize the initial events of virus-antibody interaction and will help to elucidate clinically relevant neutralization immunoregulatory mechanisms. C1 HENRY M JACKSON FDN,ROCKVILLE,MD. SRA TECHNOL,ROCKVILLE,MD. RP ROBB, ML (reprint author), WALTER REED ARMY INST RES,DEPT RETROVIRAL RES,DIV RETROVIROL,13 TAFT COURT,ROCKVILLE,MD 20850, USA. NR 21 TC 10 Z9 10 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 1077-9450 J9 J ACQ IMMUN DEF SYND JI J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. PD DEC PY 1992 VL 5 IS 12 BP 1224 EP 1229 PG 6 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA KA031 UT WOS:A1992KA03100006 PM 1453333 ER PT J AU DAVIS, WS MURCHLAND, MR BEARD, JS CRAIG, TJ AF DAVIS, WS MURCHLAND, MR BEARD, JS CRAIG, TJ TI THE TRUE STORY OF THE PILOT WHO WAS ITCHING TO FLY SO JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY LA English DT Note RP DAVIS, WS (reprint author), WALTER REED ARMY MED CTR,ALLERGY IMMUNOL SERV,WASHINGTON,DC 20407, USA. NR 4 TC 2 Z9 2 U1 1 U2 1 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0091-6749 J9 J ALLERGY CLIN IMMUN JI J. Allergy Clin. Immunol. PD DEC PY 1992 VL 90 IS 6 BP 1010 EP 1011 DI 10.1016/0091-6749(92)90481-G PN 1 PG 2 WC Allergy; Immunology SC Allergy; Immunology GA KD190 UT WOS:A1992KD19000025 PM 1460193 ER PT J AU COSMAS, GA AF COSMAS, GA TI COMBAT DIARY - EPISODES FROM THE HISTORY OF THE 22ND REGIMENT, 1866-1905 - FEUER,AB SO JOURNAL OF AMERICAN HISTORY LA English DT Book Review RP COSMAS, GA (reprint author), USA,CTR MIL HIST,WASHINGTON,DC 20310, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU ORGANIZATION AMER HISTORIANS PI BLOOMINGTON PA 112 N BRYAN ST, BLOOMINGTON, IN 47408 SN 0021-8723 J9 J AM HIST JI J. Am. Hist. PD DEC PY 1992 VL 79 IS 3 BP 1188 EP 1189 DI 10.2307/2080880 PG 2 WC History SC History GA KC313 UT WOS:A1992KC31300092 ER PT J AU GRUBER, JB HILLS, ME SELTZER, MD STEVENS, SB MORRISON, CA AF GRUBER, JB HILLS, ME SELTZER, MD STEVENS, SB MORRISON, CA TI ANALYSIS OF THE OPTICAL-SPECTRA OF TRIVALENT HOLMIUM IN YTTRIUM SCANDIUM GALLIUM GARNET SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID CRYSTAL-FIELD PARAMETERS; ENERGY-LEVELS; ROOM-TEMPERATURE; LANTHANIDE IONS; GROWTH; THULIUM; LASER; ND-3+ AB The absorption spectrum of Ho3+ ions in yttrium scandium gallium garnet (Ho3+:YSGG) is reported at 4 K between 1.93 and 0.28 mum. Laser excitation spectra and laser-excited fluorescence spectra from Ho3+(4f10)2S+1L(J) multiplet manifolds F-5(4), S-5(2), and F-5(3) to the ground-state manifold I-5(8) were obtained at 4, 8, and 70 K. Unresolved emission is observed from Ho3+ ions in slightly disturbed cation (Y3+) Sites along with emission coming from Ho3+ ions occupying the regular cation (Y3+) sites having D2 symmetry. Temperature-dependent transitions (hot bands) observed in absorption at 8 and 70 K establish experimental crystal-field split (Stark) levels in 24 excited manifolds and the seven lowest energy Stark levels in I-5(8) (Z1 = 0, Z2 = 6, Z3 = 17, Z4 = 29, Z5 = 87, Z6 = 95, and Z7 = 102, all in cm-1). An algorithm is used to establish D2 symmetry labels GAMMA1, GAMMA2, GAMMA3, or GAMMA4 of individual experimental Stark levels. These levels are compared with results obtained from a calculation in which a parameterized Hamiltonian was diagonalized within the 50 lowest multiplet manifolds of Ho3+ (4f10). Comparisons between 157 experimental Stark levels and the corresponding predicted levels out of a total of 486 calculated levels yields a root-mean-square deviation of 5 cm-1. C1 USN,CTR AIR WARFARE,DIV WEAP,RES DEPT,DIV CHEM,GREAT LAKES,IL 60088. UNIV ILLINOIS,URBANA,IL 61801. USA,ADELPHI LAB COMMAND,HARRY DIAMOND LABS,ADELPHI,MD 20783. RP GRUBER, JB (reprint author), SAN JOSE STATE UNIV,DEPT PHYS,SAN JOSE,CA 95192, USA. NR 27 TC 10 Z9 10 U1 1 U2 4 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD DEC 1 PY 1992 VL 72 IS 11 BP 5253 EP 5264 DI 10.1063/1.352008 PG 12 WC Physics, Applied SC Physics GA KA932 UT WOS:A1992KA93200032 ER PT J AU BUCHWALD, WR ZHAO, JH MCLANE, GF MEYYAPPAN, M AF BUCHWALD, WR ZHAO, JH MCLANE, GF MEYYAPPAN, M TI EFFECTS OF BCL3 MAGNETRON ION ETCHING ON DEEP LEVELS IN GAAS SO JOURNAL OF APPLIED PHYSICS LA English DT Note ID SEMICONDUCTORS AB Capacitance versus voltage curves and deep-level transient spectroscopy have been used to investigate the effects of BCl3 magnetron ion etching on the shallow donor concentration and deep-level defects in GaAs. Capacitance versus voltage data reveal that the shallow donor concentration is unaffected by the etching process at power densities ranging from 0.08 to 0.4 W/cm2. Capacitance transient measurements reveal thermal emission of electrons from two deep defect sites with activation energies of 0.25 and 0.74 eV which were unaffected by the etching process. A broad, deep-level transient spectroscopy peak, characterized by an activation energy for thermal emission of electrons of 0.37 eV, was also observed in the etched sample, but not in the unetched sample. Defect depth profiling of the 0.37 eV peak indicates the concentration of this defect to increase with increasing etch power. C1 USA,ELECTR TECHNOL & DEVICES LAB,FT MONMOUTH,NJ 07703. SCI RES ASSOCIATES INC,GLASTONBURY,CT 06033. RP BUCHWALD, WR (reprint author), RUTGERS STATE UNIV,DEPT ELECT & COMP ENGN,PISCATAWAY,NJ 08903, USA. NR 8 TC 0 Z9 0 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD DEC 1 PY 1992 VL 72 IS 11 BP 5512 EP 5513 DI 10.1063/1.351947 PG 2 WC Physics, Applied SC Physics GA KA932 UT WOS:A1992KA93200076 ER PT J AU YOUNG, PM SUTTON, JR GREEN, HJ REEVES, JT ROCK, PB HOUSTON, CS CYMERMAN, A AF YOUNG, PM SUTTON, JR GREEN, HJ REEVES, JT ROCK, PB HOUSTON, CS CYMERMAN, A TI OPERATION EVEREST-II - METABOLIC AND HORMONAL RESPONSES TO INCREMENTAL EXERCISE TO EXHAUSTION SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE ALTITUDE; PLASMA AMMONIUM; BLOOD LACTATE; INSULIN; NOREPINEPHRINE; EPINEPHRINE; PLASMA CATECHOLAMINES; EXERCISE ENDURANCE ID EXTREME ALTITUDE; SKELETAL-MUSCLE; SIMULATED ASCENT; MT EVEREST; AMMONIA; OXYGEN; ACCUMULATION; PHOSPHATE; TISSUES; INSULIN AB The reasons for the reduced exercise capacities observed at high altitudes are not completely known. Substrate availability or accumulations of lactate and ammonium could have significant roles. As part of Operation Everest II, peak oxygen uptakes were determined in five normal male volunteers with use of progressively increasing cycling work loads at ambient barometric pressures of 760, 380, and 282 Torr. Decrements from sea level (SL) to 380 and 282 Torr occurred in peak power output (19 and 47%), time to exhaustion (19 and 48%), and oxygen uptake (41 and 61%), respectively. Arterial saturations after exhaustive exercise were decreased to 63% at 380 Torr and 39% at 282 Torr. At 380 and 282 Torr, postexercise plasma concentrations of glucose and free fatty acids were not increased, whereas plasma glycerol concentrations were decreased relative to SL (145 +/- 24 muM at 380 Torr and 77 +/- 10 muM at 282 Torr vs. 213 +/- 24 muM at SL). Preexercise plasma insulin concentrations were elevated at both 380 and 282 Torr (87 +/- 16 pM at 380 Torr and 85 +/- 18 pM at 282 Torr vs. 41 +/- 30 pM at SL). In general, postexercise concentrations of plasma catecholamines were decreased at altitude compared with SL. Preexercise lactate and ammonium concentrations were not different at any simulated altitude. From these data neither substrate availability nor metabolic product accumulation limited exercise capacity at extreme simulated altitude. C1 USA,ENVIRONM MED RES INST,DIV ALTITUDE PHYSIOL & MED,NATICK,MA 01760. MCMASTER UNIV,DEPT MED,HAMILTON L8N 3Z5,ONTARIO,CANADA. UNIV WATERLOO,DEPT KINESIOL,WATERLOO N2L 3G1,ONTARIO,CANADA. UNIV COLORADO,MED CTR,DEPT MED,DENVER,CO 80262. UNIV VERMONT,DEPT MED,BURLINGTON,VT 05401. NR 32 TC 34 Z9 35 U1 2 U2 3 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 8750-7587 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD DEC PY 1992 VL 73 IS 6 BP 2574 EP 2579 PG 6 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA KE844 UT WOS:A1992KE84400053 PM 1490971 ER PT J AU CHATFIELD, DC REEVES, MS TRUHLAR, DG DUNECZKY, C SCHWENKE, DW AF CHATFIELD, DC REEVES, MS TRUHLAR, DG DUNECZKY, C SCHWENKE, DW TI COMPLEX GENERALIZED MINIMAL RESIDUAL ALGORITHM FOR ITERATIVE SOLUTION OF QUANTUM-MECHANICAL REACTIVE SCATTERING EQUATIONS SO JOURNAL OF CHEMICAL PHYSICS LA English DT Article ID KOHN VARIATIONAL PRINCIPLE; INTEGRAL CROSS-SECTIONS; S-MATRIX VERSION; NONSYMMETRIC LINEAR-SYSTEMS; LOG DERIVATIVE VERSION; BASIS-SET CALCULATIONS; MANY-BODY EXPANSION; CHEMICAL-REACTIONS; HYPERSPHERICAL METHOD; H+H2 REACTION AB A complex GMRes (general zed minimum residual) algorithm is presented and dense systems of linear equations arising in variational basis-set approach s to quantum-mechanical reactive scattering. The examples presented correspond to physical solutions of the Schrodinger equation for the reactions O + HD --> OH + D, D + H-2 --> HD + H, and H + H-2 --> H-2 + H. It is shown that the computational effort for solution with GMRes depends upon both the dimension of the linear system and the total energy of the reaction. In several cases with dimensions in the range 1110-5632, GMRes outperforms the LAPACK direct solver, with speedups for the linear equation solution as large as a factor of 23. In other cases, the iterative algorithm does not converge within a reasonable time. These convergence differences can be correlated with "indices of diagonal dominance," which we define in detail and which are relatively easy to compute. Furthermore, we find that for a given energy, the computational effort for GMRes can vary with dimension as favorably as M1.7, where M is the dimension of the linear system, whereas the computer time for a direct method is approximately proportional to the cube of the dimension of the linear system. C1 UNIV MINNESOTA, INST SUPERCOMP, DEPT CHEM, MINNEAPOLIS, MN 55455 USA. UNIV MINNESOTA, USA, HIGH PERFORMANCE COMP RES CTR, MINNEAPOLIS, MN 55455 USA. KANSAS STATE UNIV AGR & APPL SCI, DEPT CHEM, MANHATTAN, KS 66506 USA. NASA, AMES RES CTR, MOFFETT FIELD, CA 94035 USA. RI schwenke, david/I-3564-2013; Truhlar, Donald/G-7076-2015 OI Truhlar, Donald/0000-0002-7742-7294 NR 81 TC 11 Z9 11 U1 0 U2 1 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-9606 J9 J CHEM PHYS JI J. Chem. Phys. PD DEC 1 PY 1992 VL 97 IS 11 BP 8322 EP 8333 DI 10.1063/1.463402 PG 12 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA KA706 UT WOS:A1992KA70600047 ER PT J AU SHERIDAN, R AF SHERIDAN, R TI DIAGNOSIS OF THE ACUTE ABDOMEN IN THE NEUROLOGICALLY STABLE SPINAL-CORD INJURED PATIENT - A CASE-STUDY SO JOURNAL OF CLINICAL GASTROENTEROLOGY LA English DT Article DE SPINAL CORD INJURY; ACUTE ABDOMEN AB The diagnosis of the acute abdomen in the spinal cord injured patient is difficult. Diagnoses are often so delayed that approximately 10% of these patients die of acute abdominal problems. The presentation also varies with the level and duration of injury. An understanding of the functional neuroanatomy of the abdominal wall and viscera aids in timely diagnosis. I present an illustrative case and describe the pertinent functional neuroanatomy. C1 EVANS US ARMY COMMUNITY HOSP,GEN SURG SERV,FT CARSON,CO. NR 19 TC 10 Z9 10 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0192-0790 J9 J CLIN GASTROENTEROL JI J. Clin. Gastroenterol. PD DEC PY 1992 VL 15 IS 4 BP 325 EP 328 DI 10.1097/00004836-199212000-00012 PG 4 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA KE880 UT WOS:A1992KE88000011 PM 1294639 ER PT J AU DOOLEY, DP HOLLSTEN, DA GRIMES, SR MOSS, J AF DOOLEY, DP HOLLSTEN, DA GRIMES, SR MOSS, J TI INDOLENT ORBITAL APEX SYNDROME CAUSED BY OCCULT MUCORMYCOSIS SO JOURNAL OF CLINICAL NEURO-OPHTHALMOLOGY LA English DT Article ID TRANSFERRIN; MECHANISM AB The chronic or indolent presentation of rhino-orbital mucormycosis, as defined by the presence of symptoms for more than 1 month before diagnosis, is extremely unusual. A 45-year-old man with stable diabetes presented with a right orbital apex syndrome and minimal ethmoid and sphenoid sinusitis. Progression was indolent, and the diagnosis was not made until 7 weeks after admission, when a third biopsy was prompted by new cavernous sinus and carotid artery thromboses. Mucormycosis was found. The patient improved on amphotericin B (2 g) and strict blood glucose control. A remarkable aberrant regeneration of the right oculomotor nerve was seen following treatment. He remains free of active disease 4 years later. Orbital symptoms in well-controlled diabetics, which may even remain stable for weeks and lack direct signs of tissue invasion, should raise the suspicion of mucormycosis. C1 BROOKE ARMY MED CTR,DEPT MED,FT SAM HOUSTON,TX 78234. BROOKE ARMY MED CTR,DEPT OPHTHALMOL,FT SAM HOUSTON,TX 78234. BROOKE ARMY MED CTR,DEPT OTOLARYNGOL,FT SAM HOUSTON,TX 78234. NR 13 TC 28 Z9 28 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0272-846X J9 J CLIN NEURO-OPHTHAL PD DEC PY 1992 VL 12 IS 4 BP 245 EP 249 PG 5 WC Neurosciences; Ophthalmology SC Neurosciences & Neurology; Ophthalmology GA KB691 UT WOS:A1992KB69100007 PM 1287049 ER PT J AU CAMFIELD, FE AF CAMFIELD, FE TI REPORT OF THE 54TH MEETING - COASTAL-ENGINEERING-RESEARCH-BOARD SO JOURNAL OF COASTAL RESEARCH LA English DT Editorial Material RP CAMFIELD, FE (reprint author), USA,ENGINEER WATERWAYS,COASTAL ENGN RES CTR,VICKSBURG,MS 39180, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU COASTAL EDUCATION & RESEARCH FOUNDATION PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 SN 0749-0208 J9 J COASTAL RES JI J. Coast. Res. PD WIN PY 1992 VL 8 IS 1 BP 226 EP 227 PG 2 WC Environmental Sciences; Geography, Physical; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Physical Geography; Geology GA HB254 UT WOS:A1992HB25400019 ER PT J AU CAMFIELD, FE AF CAMFIELD, FE TI REPORT OF THE CORPS-OF-ENGINEERS REGIONAL COASTAL WORKSHOP SO JOURNAL OF COASTAL RESEARCH LA English DT Editorial Material RP CAMFIELD, FE (reprint author), USA,ENGINEER WATERWAYS,COASTAL ENGN RES CTR,VICKSBURG,MS 39180, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU COASTAL EDUCATION & RESEARCH FOUNDATION PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 SN 0749-0208 J9 J COASTAL RES JI J. Coast. Res. PD WIN PY 1992 VL 8 IS 1 BP 229 EP 230 PG 2 WC Environmental Sciences; Geography, Physical; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Physical Geography; Geology GA HB254 UT WOS:A1992HB25400021 ER PT J AU RASLEAR, TG SHURTLEFF, D SIMMONS, L AF RASLEAR, TG SHURTLEFF, D SIMMONS, L TI LOUDNESS BISECTION AND MASKING IN THE RAT (RATTUS-NORVEGICUS) SO JOURNAL OF COMPARATIVE PSYCHOLOGY LA English DT Article ID BIAS AB The bisection method of animal psychophysical scaling was examined as a measurement procedure. The critical assumptions of bisection scaling, as described by Pfanzagl (1968), were tested to determine if a valid equal-interval scale could be derived. A valid scale was derived in which loudness for the rat (Rattus norvegicus; n = 13) was a power function of sound pressure for 4-kHz tones. Masking noise reduced the discriminability of tonal stimuli but did not affect the bisection point. This result is consistent with an interval scale representation of loudness and demonstrates scale meaningfulness. Loudness bisection data that have been reported in the literature for 3 species (humans, rats, and pigeons) are in substantial agreement with our results. C1 WALTER REED ARMY INST RES,DEPT MED NEUROSCI,WASHINGTON,DC 20307. USN,RES INST,THERMAL STRESS ADAPT PROGRAM,BETHESDA,MD 20814. RP RASLEAR, TG (reprint author), WALTER REED ARMY INST RES,DEPT MICROWAVE RES,WASHINGTON,DC 20307, USA. NR 23 TC 3 Z9 3 U1 0 U2 1 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 SN 0735-7036 J9 J COMP PSYCHOL JI J. Comp. Psychol. PD DEC PY 1992 VL 106 IS 4 BP 374 EP 382 DI 10.1037/0735-7036.106.4.374 PG 9 WC Behavioral Sciences; Psychology; Psychology, Multidisciplinary; Zoology SC Behavioral Sciences; Psychology; Zoology GA JY565 UT WOS:A1992JY56500007 PM 1451420 ER PT J AU CRAMER, CJ TRUHLAR, DG AF CRAMER, CJ TRUHLAR, DG TI AM1-SM2 AND PM3-SM3 PARAMETERIZED SCF SOLVATION MODELS FOR FREE-ENERGIES IN AQUEOUS-SOLUTION SO JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN LA English DT Review DE FREE ENERGY; HYDRATION; MOLECULAR MODELING; SOLUBILITY; SOLVENT-ACCESSIBLE SURFACE AREA ID MOLECULAR-ORBITAL THEORY; REACTION FIELD-THEORY; CAVITY SURFACE-AREA; SEMIEMPIRICAL METHODS; SOLVENT WATER; GAS-PHASE; GROUND-STATES; CHARGE MODEL; PEPTIDE-BOND; SN2 REACTION AB Two new continuum solvation models have been presented recently, and in this paper they are explained and reviewed in detail with further examples. Solvation Model 2 (AM1-SM2) is based on the Austin Model 1 and Solvation Model 3 (PM3-SM3) on the Parameterized Model 3 semiempirical Hamiltonian. In addition to the incorporation of phosphorus parameters, both of these new models address specific deficiencies in the original Solvation Model 1 (AM1-SM1). viz., (1) more accurate account is taken of the hydrophobic effect of hydrocarbons, (2) assignment of heavy-atom surface tensions is based on the presence or absence of bonded hydrogen atoms, and (3) the treatment of specific hydration-shell water molecules is more consistent. The new models offer considerably improved performance compared to AM1-SM1 for neutral molecules and essentially equivalent performance for ions. The solute charges within the Parameterized Model 3 Hamiltonian limit the utility of PM3-SM3 for compounds containing nitrogen and possibly phosphorus. For other systems both AM1-SM2 and PM3-SM3 give realistic results, but AM1-SM2 in general outperforms PM3-SM3. Key features of the models are discussed with respect to alternative approaches. C1 USA, CTR CHEM RES DEV & ENGN, RES DIRECTORATE, DIV PHYS, ABERDEEN PROVING GROUND, MD 21010 USA. UNIV MINNESOTA, INST SUPERCOMP, MINNEAPOLIS, MN 55455 USA. RI Truhlar, Donald/G-7076-2015; Cramer, Christopher/B-6179-2011 OI Truhlar, Donald/0000-0002-7742-7294; Cramer, Christopher/0000-0001-5048-1859 NR 105 TC 324 Z9 326 U1 2 U2 14 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 0920-654X J9 J COMPUT AID MOL DES JI J. Comput.-Aided Mol. Des. PD DEC PY 1992 VL 6 IS 6 BP 629 EP 666 DI 10.1007/BF00126219 PG 38 WC Biochemistry & Molecular Biology; Biophysics; Computer Science, Interdisciplinary Applications SC Biochemistry & Molecular Biology; Biophysics; Computer Science GA KH067 UT WOS:A1992KH06700007 PM 1291630 ER PT J AU BAKTIS, PA AF BAKTIS, PA TI THE DUBLIN STATEMENT AND WOMENS ORDINATION SO JOURNAL OF ECUMENICAL STUDIES LA English DT Article C1 PIKES PEAK COMMUNITY COLL,COLORADO SPRINGS,CO 80906. RP BAKTIS, PA (reprint author), USA,FT SILL,OK 73503, USA. NR 19 TC 0 Z9 0 U1 0 U2 0 PU J ECUMENICAL STUDIES PI PHILADELPHIA PA TEMPLE UNIV - 022-38, PHILADELPHIA, PA 19122 SN 0022-0558 J9 J ECUMENICAL STUD JI J. Ecum. Stud. PD WIN PY 1992 VL 29 IS 1 BP 35 EP 46 PG 12 WC Religion SC Religion GA LH275 UT WOS:A1992LH27500003 ER PT J AU BAUMGARTNER, JC CUENIN, PR AF BAUMGARTNER, JC CUENIN, PR TI EFFICACY OF SEVERAL CONCENTRATIONS OF SODIUM-HYPOCHLORITE FOR ROOT-CANAL IRRIGATION SO JOURNAL OF ENDODONTICS LA English DT Article ID SCANNING ELECTRON-MICROSCOPE; SMEAR LAYER; REMOVAL; INSTRUMENTATION AB Sodium hypochlorite (NaOCl) has been recommended for irrigation during root canal preparation. This investigation used scanning electron microscopy to examine instrumented and uninstrumented surfaces in the middle third of root canals following the use of several concentrations of NaOCl (5.25%, 2.5%, 1.0%, and 0.5%). NaoCl was delivered with either an endodontic irrigation needle or an ultrasonic device. All of the concentrations of NaOCl with either delivery system were very effective in flushing out loose debris from the root canals. A smear layer with some exposed dentinal tubules was seen on all instrumented surfaces regardless of concentration of NaOCl or irrigation device. NaOCl in concentrations of 5.25%, 2.5%, and 1% completely removed pulpal remnants and predentin from the uninstrumented surfaces. Although 0.5% NaOCl removed the majority of pulpal remnants and predentin from the uninstrumented surfaces, it left some fibrils on the surface. C1 WALTER REED ARMY MED CTR,FAC DENT RES,WASHINGTON,DC 20307. RP BAUMGARTNER, JC (reprint author), OREGON HLTH SCI UNIV,SCH DENT,DEPT ENDODONTOL,611 SW CAMPUS DR,PORTLAND,OR 97201, USA. NR 20 TC 104 Z9 114 U1 2 U2 8 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0099-2399 J9 J ENDODONT JI J. Endod. PD DEC PY 1992 VL 18 IS 12 BP 605 EP 612 DI 10.1016/S0099-2399(06)81331-2 PG 8 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA KD710 UT WOS:A1992KD71000005 PM 1298800 ER PT J AU PETEN, EP STRIKER, LJ CAROME, MA ELLIOTT, SJ YANG, CW STRIKER, GE AF PETEN, EP STRIKER, LJ CAROME, MA ELLIOTT, SJ YANG, CW STRIKER, GE TI THE CONTRIBUTION OF INCREASED COLLAGEN-SYNTHESIS TO HUMAN GLOMERULOSCLEROSIS - A QUANTITATIVE-ANALYSIS OF ALPHA-2IV COLLAGEN MESSENGER-RNA EXPRESSION BY COMPETITIVE POLYMERASE CHAIN-REACTION SO JOURNAL OF EXPERIMENTAL MEDICINE LA English DT Article ID GROWTH-HORMONE; EXTRACELLULAR-MATRIX; IV COLLAGEN; LAMININ; KIDNEY AB We previously reported that one of the main components of the sclerotic material in human glomerular diseases was type IV collagen. In this study we examined the contribution of increased synthesis to this process at the gene expression level. Sufficient material has not been available to study type IV collagen synthesis by normal or sclerotic glomeruli in humans. We took advantage of the availability of nephrectomy specimens from patients with renal carcinoma, and of the observation that approximately 50% of these patients develop varying degrees of glomerulosclerosis. We microdissected glomeruli from 10 patients and analyzed them using in situ reverse transcription coupled with polymerase chain reaction (PCR) analyses (in situ RT-PCR). Alpha2IV collagen mRNA, after reverse transcription into cDNA, was detected in all patients and appeared to be increased in those with glomerulosclerosis (n = 5). A competitive PCR assay was developed to quantitate this change. There was an average 3.7-fold increase in glomerular type IV collagen cDNA in patients with significant sclerosis. This change was not due to an increased number of glomerular cells. Thus, glomerulosclerosis in humans is associated with an elevation of glomerular type IV collagen gene expression, suggesting that increased synthesis of type IV collagen may represent one component of this process. C1 NIDDKD,METAB DIS BRANCH,RENAL CELL BIOL SECT,BLDG 10,RM 3N110,BETHESDA,MD 20892. WALTER REED ARMY MED CTR,DEPT MED,NEPHROL SERV,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. NR 21 TC 78 Z9 81 U1 0 U2 0 PU ROCKEFELLER UNIV PRESS PI NEW YORK PA 1114 FIRST AVE, 4TH FL, NEW YORK, NY 10021 SN 0022-1007 J9 J EXP MED JI J. Exp. Med. PD DEC 1 PY 1992 VL 176 IS 6 BP 1571 EP 1576 DI 10.1084/jem.176.6.1571 PG 6 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA KA481 UT WOS:A1992KA48100010 PM 1281210 ER PT J AU GENIS, P JETT, M BERNTON, EW BOYLE, T GELBARD, HA DZENKO, K KEANE, RW RESNICK, L MIZRACHI, Y VOLSKY, DJ EPSTEIN, LG GENDELMAN, HE AF GENIS, P JETT, M BERNTON, EW BOYLE, T GELBARD, HA DZENKO, K KEANE, RW RESNICK, L MIZRACHI, Y VOLSKY, DJ EPSTEIN, LG GENDELMAN, HE TI CYTOKINES AND ARACHIDONIC METABOLITES PRODUCED DURING HUMAN-IMMUNODEFICIENCY-VIRUS (HIV)-INFECTED MACROPHAGE-ASTROGLIA INTERACTIONS - IMPLICATIONS FOR THE NEUROPATHOGENESIS OF HIV DISEASE SO JOURNAL OF EXPERIMENTAL MEDICINE LA English DT Article ID TUMOR-NECROSIS-FACTOR; IMMUNE-DEFICIENCY-SYNDROME; CENTRAL-NERVOUS-SYSTEM; AIDS-RELATED COMPLEX; HUMAN GLIAL-CELLS; HTLV-III; CEREBROSPINAL-FLUID; ALPHA PRODUCTION; QUINOLINIC ACID; FRONTAL-CORTEX AB Human immunodeficiency virus (HIV) infection of brain macrophages and astroglial proliferation are central features of HIV-induced central nervous system (CNS) disorders. These observations suggest that glial cellular interactions participate in disease. In an experimental system to examine this process, we found that cocultures of HIV-infected monocytes and astroglia release high levels of cytokines and arachidonate metabolites leading to neuronotoxicity. HIV-1ADA-infected monocytes cocultured with human glia (astrocytoma, neuroglia, and primary human astrocytes) synthesized tumor necrosis factor (TNF-alpha) and interleukin 1beta (IL-1beta) as assayed by coupled reverse transcription-polymerase chain reaction, enzyme-linked immunosorbent assay, and biological activity. The cytokine induction was selective, cell specific, and associated with induction of arachidonic acid metabolites. TNF-beta, IL-1alpha, IL-6, interferon alpha (IFN-alpha), and IFN-gamma were not produced. Leukotriene B4, leukotriene D4, lipoxin A4, and platelet-activating factor were detected in large amounts after high-performance liquid chromatography separation and correlated with cytokine activity. Specific inhibitors of the arachidonic cascade markedly diminished the cytokine response suggesting regulatory relationships between these factors. Cocultures of HIV-infected monocytes and neuroblastoma or endothelial cells, or HIV-infected monocyte fluids, sucrose gradient-concentrated viral particles, and paraformaldehyde-fixed or freeze-thawed HIV-infected monocytes placed onto astroglia failed to induce cytokines and neuronotoxins. This demonstrated that viable monocyte-astroglia interactions were required for the cell reactions. The addition of actinomycin D or cycloheximide to the HIV-infected monocytes before coculture reduced, >2.5-fold, the levels of TNF-alpha. These results, taken together, suggest that the neuronotoxicity associated with HIV central nervous system disorders is mediated, in part, through cytokines and arachidonic acid metabolites, produced during cell-to-cell interactions between HIV-infected brain macrophages and astrocytes. C1 WALTER REED ARMY INST RES, DEPT CELLULAR IMMUNOL, WASHINGTON, DC 20307 USA. WALTER REED ARMY INST RES, DEPT MOLEC PATHOL, WASHINGTON, DC 20307 USA. WALTER REED ARMY INST RES, DEPT BACTERIAL DIS, WASHINGTON, DC 20307 USA. UNIV ROCHESTER, MED CTR, DEPT PEDIAT, ROCHESTER, NY 14642 USA. UNIV ROCHESTER, MED CTR, DEPT NEUROL, ROCHESTER, NY 14642 USA. UNIV MIAMI, SCH MED, DEPT PHYSIOL & BIOPHYS, MIAMI, FL 33140 USA. MT SINAI MED CTR, DEPT RES, MIAMI, FL 33140 USA. ST LUKES ROOSEVELT HOSP, MOLEC VIROL LAB, NEW YORK, NY 10025 USA. COLUMBIA UNIV, COLL PHYS & SURG, NEW YORK, NY 10019 USA. RI Mizrachi Nebenzahl, Yaffa/F-1657-2012 FU NHLBI NIH HHS [HL-43628, R01 HL043628]; NIAID NIH HHS [AI-32305]; NINDS NIH HHS [NS-28754] NR 80 TC 489 Z9 497 U1 3 U2 7 PU ROCKEFELLER UNIV PRESS PI NEW YORK PA 1114 FIRST AVE, 4TH FL, NEW YORK, NY 10021 USA SN 0022-1007 J9 J EXP MED JI J. Exp. Med. PD DEC 1 PY 1992 VL 176 IS 6 BP 1703 EP 1718 DI 10.1084/jem.176.6.1703 PG 16 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA KA481 UT WOS:A1992KA48100026 PM 1460427 ER PT J AU KEEVIN, TM YARBROUGH, RE MILLER, AC AF KEEVIN, TM YARBROUGH, RE MILLER, AC TI LONG-DISTANCE DISPERSAL OF ZEBRA MUSSELS (DREISSENA-POLYMORPHA) ATTACHED TO HULLS OF COMMERCIAL VESSELS SO JOURNAL OF FRESHWATER ECOLOGY LA English DT Note AB In April 1992, more than 1,000 adult zebra mussels (Dreissena polymorpha) were found on the hull of a commercial barge in dry-dock in Hartford, IL. The shell lengths of randomly chosen individuals ranged from 11.6 - 21.1 mm. During the.period of likely attachment to the time of dry-docking zebra mussels were transported a total distance of approximately 15,884 km through the upper Mississippi, lower Mississippi, and.Illinois rivers. The potential for dispersal of mussels via commercial vessels is considerable. C1 WATERWAYS EXPT STN,ENVIRONM LAB,VICKSBURG,MS 39180. RP KEEVIN, TM (reprint author), USA,ENGINEER DIST ST LOUIS,1222 SPRUCE ST,ST LOUIS,MO 63103, USA. NR 1 TC 24 Z9 24 U1 0 U2 3 PU OIKOS PUBL INC PI LA CROSSE PA PO BOX 2558, LA CROSSE, WI 54601 SN 0270-5060 J9 J FRESHWATER ECOL JI J. Freshw. Ecol. PD DEC PY 1992 VL 7 IS 4 BP 437 EP 437 DI 10.1080/02705060.1992.9664715 PG 1 WC Ecology; Limnology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA KD815 UT WOS:A1992KD81500011 ER PT J AU WEINSTEIN, SA DEWITT, CF SMITH, LA AF WEINSTEIN, SA DEWITT, CF SMITH, LA TI VARIABILITY OF VENOM-NEUTRALIZING PROPERTIES OF SERUM FROM SNAKES OF THE COLUBRID GENUS LAMPROPELTIS SO JOURNAL OF HERPETOLOGY LA English DT Article; Proceedings Paper CT SYMP ON AMPHIBIAN DECLINES AND HABITAT ACIDIFICATION, AT THE 1991 ANNUAL MEETING OF THE SOC FOR THE STUDY OF AMPHIBIANS AND REPTILES AND THE HERPETOLOGISTS LEAGUE CY AUG 08, 1991 CL UNIVERSITY PARK, PA SP SOC STUDY AMPHIBIANS & REPTILES, HEPETOLOGISTS LEAGUE ID ANTIHEMORRHAGIC FACTOR; PURIFICATION; COPPERHEAD; TOXICITY AB Venom neutralization properties and protein content of serum from 11 taxa of Lampropeltis were studied. Most serum samples contained 6.5% to 9.5% protein. Lampropeltis g. getulus and L. g. floridana serum showed the broadest spectrum of effective neutralization of venoms from 10 crotaline taxa. Lampropeltis t. triangulum, L. t. hondurensis, L. mexicana greeri, and L. alterna effectively neutralized many of the venoms assayed, but were less efficacious than the other Lampropeltis species tested. Most of the serum samples investigated had variably effective neutralization capacities for venoms with strong hemorrhagic activities (Crotalus atrox, C. adamanteus, C. v. viridis). Sera from L. g. holbrooki and L. g. floridana were particularly effective in neutralizing venoms of Agkistrodon piscivorus conanti and A. contortrix mokasen. Only L. g. getulus, L. g. floridana, and L. ruthveni sera neutralized over 100 LD50 of C. v. helleri venom per ml. Only four serum samples (L. g. getulus, L. g. floridana, L. calligaster, and L. t. triangulum) were effective against type A C. s. scutulatus venom (contained high concentrations of the potent neurotoxin, Mojave toxin). All Lampropeltis sera assayed had effective neutralization potential for type B C. s. scutulatus venom, which has strong hemorrhagic and proteolytic activities and lacks Mojave toxin. All serum samples assayed were ineffective against venom of the elapid Micrurus f. fulvius. Serum from Elaphe g. guttata effectively neutralized several crotaline venoms, while Rhinocheilus lecontei antonii serum had only marginal neutralization capacity for several venoms. Serum from Pituophis melanoleucus sayi and the natricine Thamnophis s. sirtalis had no neutralization capacity for any venom tested. Venom-neutralizing serum proteins of Lampropeltis appear to be most effective against hemorrhagic and proteolytic venoms, with little or no neutralization capacities against venoms containing high concentrations of hypotensive peptides, post- or presynaptically acting neurotoxins, and/or myolytic phospholipases A2. RP WEINSTEIN, SA (reprint author), USA,MED RES INST INFECT DIS,DEPT IMMUNOL & MOLEC BIOL,DIV TOXINOL,FREDERICK,MD 21701, USA. NR 73 TC 7 Z9 7 U1 1 U2 4 PU SOC STUDY AMPHIBIANS REPTILES PI OXFORD PA MIAMI UNIV, DEPT ZOOLOGY, OXFORD, OH 45056 SN 0022-1511 J9 J HERPETOL JI J. Herpetol. PD DEC PY 1992 VL 26 IS 4 BP 452 EP 461 DI 10.2307/1565123 PG 10 WC Zoology SC Zoology GA KD179 UT WOS:A1992KD17900014 ER PT J AU SOISSON, LMA MASTERSON, CP TOM, TD MCNALLY, MT LOWELL, GH STRAND, M AF SOISSON, LMA MASTERSON, CP TOM, TD MCNALLY, MT LOWELL, GH STRAND, M TI INDUCTION OF PROTECTIVE IMMUNITY IN MICE USING A 62-KDA RECOMBINANT FRAGMENT OF A SCHISTOSOMA-MANSONI SURFACE-ANTIGEN SO JOURNAL OF IMMUNOLOGY LA English DT Article ID MYOSIN HEAVY-CHAIN; AMINO-ACID-SEQUENCE; MONOCLONAL-ANTIBODY; POLYACRYLAMIDE GELS; COMPLETE NUCLEOTIDE; MEMBRANE-PROTEINS; MOLECULAR-CLONING; VACCINATED MICE; GENE; IDENTIFICATION AB Mice exposed to radiation-attenuated cercariae of Schistosoma mansoni are highly resistant to challenge infection, and sera from these mice can confer partial resistance when transferred to naive recipients. These sera recognize Ag present in schistosomular and adult worms, among them an Ag of 200 kDa. A cDNA encoding a 62-kDa portion of this Ag was cloned; the deduced amino acid sequence of this cDNA clone shares homology with myosins of other species. To assess the immunoprophylactic potential, we carried out vaccination trials in mice using the recombinant polypeptide expressed as a fusion protein with beta-galactosidase presented in the form of proteosome complexes with the outer membrane protein of meningococcus. The level of protection achieved was 32%, and this level could be increased to 75% by removal of those amino acids included in the fusion protein that were derived from the vector to yield a polypeptide, designated rIrV-5. A similar level of protection was achieved when mice were immunized with the same dose of rIrV-5 in the form of protein complexes but without outer membrane protein, suggesting that protection did not require the use of adjuvant. However, at least three immunizations were necessary to achieve protection. Using mAb and sera from mice vaccinated with rIrV-5, we demonstrated that the native protein recognized by antibodies against rIrV-5 is a 200-kDa protein that is expressed on the surface of newly transformed schistosomula. The protection achieved with rIrV-5 in mice encourages additional studies of its potential as a vaccine candidate for the prevention of schistosomiasis. C1 JOHNS HOPKINS UNIV,SCH MED,DEPT PHARMACOL & MOLEC SCI,725 N WOLFE ST,BALTIMORE,MD 21205. WALTER REED ARMY INST RES,DEPT BACTERIAL DIS,WASHINGTON,DC 20307. FU NIAID NIH HHS [AI-19217] NR 55 TC 78 Z9 86 U1 0 U2 1 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD DEC 1 PY 1992 VL 149 IS 11 BP 3612 EP 3620 PG 9 WC Immunology SC Immunology GA JY875 UT WOS:A1992JY87500026 PM 1431131 ER PT J AU YAMAMOTO, T KOYAMA, Y MATSUMOTO, M SONODA, E NAKAYAMA, S UCHIMURA, M PAVEENKITTIPORN, W TAMURA, K YOKOTA, T ECHEVERRIA, P AF YAMAMOTO, T KOYAMA, Y MATSUMOTO, M SONODA, E NAKAYAMA, S UCHIMURA, M PAVEENKITTIPORN, W TAMURA, K YOKOTA, T ECHEVERRIA, P TI LOCALIZED, AGGREGATIVE, AND DIFFUSE ADHERENCE TO HELA-CELLS, PLASTIC, AND HUMAN SMALL-INTESTINES BY ESCHERICHIA-COLI ISOLATED FROM PATIENTS WITH DIARRHEA SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID CHOLERAE O1 ADHERENCE; TISSUE-CULTURE CELLS; VIBRIO-CHOLERAE; HEP-2 CELLS; PEYERS PATCHES; PLASMID; ENTEROADHERENT; PATTERNS; ADHESION; INVITRO AB Adherence of diarrhea-associated Escherichia coli was studied by scanning electron microscopy. Enteropathogenic E. coli (EPEC) adherence factor-positive (EAF+) E. coli of EPEC serotypes (class I EPEC) adhered to plastic and human jejunal and ileal mucosa, similar to case and HeLa cells. Localized adherence, elongation of cell microvilli, and "locking" of the bacterial aggregates by the elongated microvilli were evident after incubation for 20 min. EAF+ E. coli adhered strikingly to mucus but rarely to M cells in Peyer's patch-associated epithelium. Most enteroaggregative E. coli (EAggEC) strains adhered to plastic, similar to HeLa cells. Some diffuse-adhering E. coli (DAEC) strains displayed no adherence to plastic but formed "dimples" on HeLa cells. Both EAggEC and DAEC adhered at lower levels to human small intestines (except M cells) than did EAF+ E. coli. In all cases of EAF- E. coli, EAggEC, and DAEC, strains were found with atypical characteristics. The data demonstrate the unique adherence characteristics of EAF+ E. coli, EAggEC, and DAEC. C1 NATL INST HLTH,TOKYO 141,JAPAN. ARMED FORCES RES INST MED SCI,BANGKOK,THAILAND. RP YAMAMOTO, T (reprint author), JUNTENDO UNIV,SCH MED,DEPT BACTERIOL,2-1-1 HONGO,BUNKYO KU,TOKYO 113,JAPAN. NR 54 TC 44 Z9 48 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD DEC PY 1992 VL 166 IS 6 BP 1295 EP 1310 PG 16 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA JZ581 UT WOS:A1992JZ58100013 PM 1358987 ER PT J AU TERKUILE, FO NOSTEN, F THIEREN, M LUXEMBURGER, C EDSTEIN, MD CHONGSUPHAJAISIDDHI, T PHAIPUN, L WEBSTER, HK WHITE, NJ AF TERKUILE, FO NOSTEN, F THIEREN, M LUXEMBURGER, C EDSTEIN, MD CHONGSUPHAJAISIDDHI, T PHAIPUN, L WEBSTER, HK WHITE, NJ TI HIGH-DOSE MEFLOQUINE IN THE TREATMENT OF MULTIDRUG-RESISTANT FALCIPARUM-MALARIA SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID THAI-BURMESE BORDER; III CLINICAL-TRIAL; PLASMODIUM-FALCIPARUM; SULFADOXINE-PYRIMETHAMINE; CHILDREN; PHARMACOKINETICS; KINETICS; THERAPY; ADULTS; FIELD AB The therapeutic efficacy and toxicity of a high-dose (25 mg/kg) mefloquine regimen (M25) and the currently recommended regimen of 15 mg/kg (M15) were compared in 199 patients with acute falciparum malaria in an area with deteriorating multidrug resistance on the Thai-Burmese border. The clinical and parasitologic responses were significantly more rapid with M25. The incidence of treatment failures by day 7-9 was 7% for M15 and 7% for M 25 (P = .03) and had increased to 40% and 9%, respectively, by day 28 (P < .000 1). Overall failure rates were highest in children (P = .02). Parasite clearance times were a good predictor of the therapeutic response; all patients with parasitemia persisting >5 days after treatment experienced subsequent recrudescence. Side effects were dose-related and included dizziness, anorexia, nausea, vomiting, and fatigue. Although vomiting <1 h after treatment was more likely in young children, children overall tolerated mefloquine better than adults, and men better than women. The optimum treatment dose of mefloquine in this area is 25 mg/kg. C1 ARMED FORCES RES INST MED SCI,USA MED COMPONENT,BANGKOK,THAILAND. SHOKLO MALARIA RES UNIT,MAE SOD,THAILAND. UNIV AMSTERDAM,ACAD MED CTR,INFECT DIS & TROP MED UNIT,AMSTERDAM,NETHERLANDS. WHO,DISASTER SUB REG OFF,SAN JOSE,COSTA RICA. JOHN RADCLIFFE HOSP,NUFFIELD DEPT CLIN MED,OXFORD OX3 9DU,ENGLAND. RP TERKUILE, FO (reprint author), MAHIDOL UNIV,FAC TROP MED,420-6 RAJVITHI RD,BANGKOK 10400,THAILAND. RI White, Nicholas/I-4629-2012; OI Nosten, Francois/0000-0002-7951-0745 FU Wellcome Trust NR 30 TC 78 Z9 78 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD DEC PY 1992 VL 166 IS 6 BP 1393 EP 1400 PG 8 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA JZ581 UT WOS:A1992JZ58100027 PM 1431257 ER PT J AU BROWN, AE MONGKOLSIRICHAIKUL, D INNIS, B SNITBHAN, R WEBSTER, HK AF BROWN, AE MONGKOLSIRICHAIKUL, D INNIS, B SNITBHAN, R WEBSTER, HK TI FALCIPARUM-MALARIA MODULATES VIREMIA IN CHRONIC HEPATITIS-B VIRUS-INFECTION SO JOURNAL OF INFECTIOUS DISEASES LA English DT Letter C1 USA,MED COMPONENTS,ARMED FORCES RES INST MED SCI,DEPT IMMUNOL,BANGKOK,THAILAND. USA,MED COMPONENTS,ARMED FORCES RES INST MED SCI,DEPT VIROL,BANGKOK,THAILAND. NR 6 TC 9 Z9 9 U1 0 U2 1 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD DEC PY 1992 VL 166 IS 6 BP 1465 EP 1466 PG 2 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA JZ581 UT WOS:A1992JZ58100049 PM 1431272 ER PT J AU CANTILENA, LR SMITH, RP FRASUR, S KRUSZYNA, H KRUSZYNA, R WILCOX, DE AF CANTILENA, LR SMITH, RP FRASUR, S KRUSZYNA, H KRUSZYNA, R WILCOX, DE TI NITRIC-OXIDE HEMOGLOBIN IN PATIENTS RECEIVING NITROGLYCERIN AS DETECTED BY ELECTRON-PARAMAGNETIC RESONANCE SPECTROSCOPY SO JOURNAL OF LABORATORY AND CLINICAL MEDICINE LA English DT Article ID BIOLOGICAL-ACTIVITY; RELAXING FACTOR; CELLS; VASODILATORS; MICE AB Blood specimens were obtained from 30 adult patients admitted to a coronary care unit after the decision to use nitroglycerin had been made by their physicians. The samples were drawn before nitroglycerin administration, within 1 hour after starting nitroglycerin, after several hours of therapy, and more than 4 hours after discontinuing therapy. One patient was admitted twice, accounting for 31 sets of blood specimens. A positive identification of nitric oxide-hemoglobin (NOHb), with electron paramagnetic resonance (EPR) spectroscopy could be made in the blood of 10 of the subjects after they had been receiving nitroglycerin for several hours (third blood sample). In seven subjects this third blood sample was not drawn, and they were dropped from the study. A final positive finding of NOHb was made in 10 of 24 patients. NOHb has not been identified previously in human subjects given nitroglycerin, and a significant dose-response relationship was observed between nitroglycerin and NOHb. We ascribe our inability to detect NOHb in all subjects before nitroglycerin (basal levels) and after nitroglycerin in 14 subjects to concentrations that were below the limits of detection of the technique as used. Subtraction of the EPR signal for plasma ceruloplasmin was necessary to detect the NOHb EPR signals. Thus we have shown EPR spectroscopy to be a highly specific and sensitive method for detecting and quantifying NOHb in human subjects. Further refinements in the technique to improve sensitivity are possible. Although NOHb is said to be highly unstable, we found prepared samples of NOHb to be stable in air-saturated solutions for 30 days at or below -20-degrees-C. NOHb decayed with apparent half-lives of 40 minutes at 37-degrees, 3.5 hours at 20-degrees, and 6.6 days at 4-degrees. Thus temperature may be more critical than oxygen in determining the rate of NOHb decay. C1 WALTER REED ARMY MED CTR,DEPT MED,WASHINGTON,DC 20307. DARTMOUTH COLL,HITCHCOCK MED CTR,DARTMOUTH MED SCH,DEPT PHARMACOL & TOXICOL,HANOVER,NH 03756. DARTMOUTH COLL,DEPT CHEM,HANOVER,NH 03755. RP CANTILENA, LR (reprint author), UNIFORMED SERV UNIV HLTH SCI,F EDWARD HEBERT SCH MED,DEPT PHARMACOL & MED,BETHESDA,MD 20814, USA. FU NHLBI NIH HHS [HL 14127] NR 18 TC 47 Z9 46 U1 1 U2 3 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0022-2143 J9 J LAB CLIN MED JI J. Lab. Clin. Med. PD DEC PY 1992 VL 120 IS 6 BP 902 EP 907 PG 6 WC Medical Laboratory Technology; Medicine, General & Internal; Medicine, Research & Experimental SC Medical Laboratory Technology; General & Internal Medicine; Research & Experimental Medicine GA KA909 UT WOS:A1992KA90900016 PM 1333513 ER PT J AU MUFSON, RA MYERS, C TURPIN, JA MELTZER, M AF MUFSON, RA MYERS, C TURPIN, JA MELTZER, M TI PHORBOL ESTER REDUCES CONSTITUTIVE NUCLEAR NF-KAPPA-B AND INHIBITS HIV-1 PRODUCTION IN MATURE HUMAN MONOCYTIC CELLS SO JOURNAL OF LEUKOCYTE BIOLOGY LA English DT Article DE MONOCYTES; HIV; NUCLEAR BINDING FACTOR; PMA ID HUMAN-IMMUNODEFICIENCY-VIRUS; PROTEIN KINASE-C; LINE U-937; INFECTION; DIFFERENTIATION; AIDS; ESTABLISHMENT; REPLICATION; SPECIFICITY; EXPRESSION AB NFkappaB is a potent mediator of specific gene expression in human monocytes and has been shown to play a role in transcription of the HIV-1 genome in promonocytic leukemias. There is little information available on the response of NFkappaB to cytokines in normal human monocytes. We have used a P-32-labeled oligonucleotide derived from human immunodeficiency virus (HIV-1) long terminal repeat, which contains a tandem repeat of the NFkappaB binding sequence, as a probe in a gel retardation assay to study this transcription factor. Using this assay, we have detected NFkappaB in extracts of nuclei from normal human monocytes. Treatment of normal monocytes with 12-0-tetradecanoyl phorbol-13-acetate (TPA) for 4-24 h caused the complete disappearance of NFkappaB from nuclear extracts of monocytes. A similar result was obtained with the mature monocytic leukemia cell line THP-1. The constitutive transcription factor SP1 was unaffected by addition of TPA. The disappearance of NFkappaB from the nucleus was concentration dependent between 10 and 50 ng/ml of phorbol ester. In THP-1 cells, TPA also induced a new, faster-migrating NFkappaB species not induced in monocytes. Protein kinase C inhibitor staurosporine, but not cyclic nucleotide-dependent protein kinase inhibitor HA-1004, also dramatically reduced constitutive levels of nuclear NFkappaB. Finally, TPA addition to monocytes infected with HIV-1 inhibited HIV-1 replication, as determined by reverse transcriptase assays, in a concentration-dependent manner. These results are in striking contrast to the increase in nuclear NFkappaB and HIV-1 replication induced by phorbol esters in promonocytic leukemia cells U937 and HL-60, and emphasize the importance of studying cytokine regulation of HIV-1 in normal monocytes. C1 WALTER REED ARMY MED CTR,DEPT CELLULAR IMMUNOL,ROCKVILLE,MD. RP MUFSON, RA (reprint author), AMER RED CROSS,JEROME H HOLLAND LAB,DEPT CELL BIOL,ROCKVILLE,MD 20855, USA. FU NCI NIH HHS [R01-CA53609] NR 32 TC 12 Z9 12 U1 1 U2 2 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0741-5400 J9 J LEUKOCYTE BIOL JI J. Leukoc. Biol. PD DEC PY 1992 VL 52 IS 6 BP 637 EP 644 PG 8 WC Cell Biology; Hematology; Immunology SC Cell Biology; Hematology; Immunology GA KB968 UT WOS:A1992KB96800010 PM 1464736 ER PT J AU ENGLER, RJM MANGIAFICO, JA JAHRLING, P KSIAZEK, TG PEDROTTIKRUEGER, M PETERS, CJ AF ENGLER, RJM MANGIAFICO, JA JAHRLING, P KSIAZEK, TG PEDROTTIKRUEGER, M PETERS, CJ TI VENEZUELAN EQUINE ENCEPHALITIS-SPECIFIC IMMUNOGLOBULIN RESPONSES - LIVE ATTENUATED TC-83 VERSUS INACTIVATED C-84 VACCINE SO JOURNAL OF MEDICAL VIROLOGY LA English DT Article DE VACCINATION; IMMUNIZATION; HUMORAL; ANTIBODY; IGG SUBCLASSES; IGA; VENEZUELAN EQUINE ENCEPHALITIS ID IGG SUBCLASSES; VIRUS AB Venezuelan equine encephalitis (VEE)-specific immunoglobulin responses to the two vaccines, TC-83 (a live attenuated vaccine) and C-84 (a formalin inactivated vaccine derived from the TC-83 strain of virus) were evaluated using an antigen and isotype-specific enzyme-linked immunoadsorbent assay (ELISA). The VEE-specific ELISA for IgG, IgG subclasses, IgA and IgM were developed and standardized using sera from vaccine-exposed and unexposed human subjects. Paired human sera (before and 28 days after immunization) were tested from laboratory workers vaccinated with either TC-83 (Group A: 20 paired sera from subjects receiving a single TC-83 vaccine and with no prior history of vaccination) or C-84 in varying schedules (Group B: 19 paired sera from subjects who had a distant vaccination history to TC-83 but no evidence of neutralizing antibody; Group C: 19 paired sera from subjects receiving their first C-84 vaccination and no prior documented history of vaccination; Group D: 15 paired sera from subjects receiving a C-84 booster vaccination with prior history of C-84 but no TC-83 exposure). Sera were all tested for viral neutralization in vitro using a Vero cell monolayer for culturing virus and establishing 80% plaque reduction for each serum tested. All pre-sera tested demonstrated no plaque reduction neutralization at a level of 80% for a dilution of 1:10. ELISA antibody titers for all pre-sera with no prior VEE exposure through vaccination or possible environmental factors were negative at a titer of 1:160 for IgM, 1:80 for IgG, IgA, and G subclasses. All vaccine types and strategies generated a significant IgG response postvaccination (P < 0.0001) and this response correlated with the 80% plaque reduction neutralization titer (PRN-80) for VEE-specific IgG, G1, G3 and IgA at a P value of < 0.001 for both Group A and B. No such correlation was observed for G2 and no G4 responses to immunization were noted in any of the groups tested. There was a significant difference between geometric mean (GM) titers postvaccination for Group A or Group B versus Group C (P < 0.001) and for Group C versus Group D (P < 0.001) for IgG. Neither group C or D (1 or 2 doses of C-84 alone) demonstrated an IgA response in contrast to the TC-83 exposed groups (Groups A and B). C-84 was an effective booster vaccine in subjects previously exposed to the live attenuated vaccine and generated a significant neutralization antibody response mirrored in the IgG, G1, G3 and IgA titer increases by ELISA. C1 UNIFORMED SERV UNIV HLTH SCI,DEPT MED,BETHESDA,MD 20814. USA,MED RES INST INFECT DIS,DIV DIS ASSESSMENT,FREDERICK,MD 21701. RP ENGLER, RJM (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,ALLERGY IMMUNOL SERV,WASHINGTON,DC 20307, USA. NR 17 TC 15 Z9 15 U1 0 U2 2 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0146-6615 J9 J MED VIROL JI J. Med. Virol. PD DEC PY 1992 VL 38 IS 4 BP 305 EP 310 DI 10.1002/jmv.1890380414 PG 6 WC Virology SC Virology GA KA807 UT WOS:A1992KA80700013 PM 1474379 ER PT J AU HALL, DP YOUNG, SA AF HALL, DP YOUNG, SA TI FRONTAL-LOBE CEREBRAL ANEURYSM RUPTURE PRESENTING AS PSYCHOSIS SO JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY LA English DT Note ID INFARCTIONS AB A 23 year old male with acute onset of blunted affect, looseness of associations and auditory hallucinations presented to a tertiary care hospital 10 days after development of symptoms. Before transfer, the patient received a diagnosis of schizophreniform disorder and treatment with haloperidol was started which resulted in moderate improvement. Examination led to detection of a ruptured cerebral aneurysm in the left frontal lobe. Evacuation of the haematoma and repair of the aneurysm resulted in nearly complete resolution of symptoms. The rare incidence of acute aneurysm rupture, presenting in the case described, demonstrates the importance of a complete neurological examination in the evaluation of acute mental status changes. RP HALL, DP (reprint author), WALTER REED ARMY MED CTR,DEPT PSYCHIAT,WASHINGTON,DC 20307, USA. NR 10 TC 3 Z9 3 U1 0 U2 0 PU BRITISH MED JOURNAL PUBL GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON, ENGLAND WC1H 9JR SN 0022-3050 J9 J NEUROL NEUROSUR PS JI J. Neurol. Neurosurg. Psychiatry PD DEC PY 1992 VL 55 IS 12 BP 1207 EP 1208 DI 10.1136/jnnp.55.12.1207 PG 2 WC Clinical Neurology; Psychiatry; Surgery SC Neurosciences & Neurology; Psychiatry; Surgery GA KD370 UT WOS:A1992KD37000025 PM 1479403 ER PT J AU FAN, LL MULLEN, ALW BRUGMAN, SM INSCORE, SC PARKS, DP WHITE, CW AF FAN, LL MULLEN, ALW BRUGMAN, SM INSCORE, SC PARKS, DP WHITE, CW TI CLINICAL SPECTRUM OF CHRONIC INTERSTITIAL LUNG-DISEASE IN CHILDREN SO JOURNAL OF PEDIATRICS LA English DT Article ID RECOMBINANT INTERFERON ALFA-2A; IDIOPATHIC PULMONARY FIBROSIS; TERM FOLLOW-UP; PNEUMONIA; CHILDHOOD; CHLOROQUINE; ALVEOLITIS; DISORDERS; INFANTS AB To describe the clinical spectrum of interstitial lung disease in children, we reviewed our experience with 48 patients during a 12-year period. Most patients initially had typical findings of restrictive lung disease and hypoxemia. Growth failure or pulmonary hypertension or both were found in more than one third. Specific diagnosis, made in 35 patients (70%), most often required invasive studies, particularly open lung biopsy. Although the diagnostic yield from open lung biopsy was high, the diagnosis of many patients remained uncertain. Many different disorders were encountered. The response to corticosteroids, bronchodilators, and chloroquine was inconsistent. Six patients died, five within 1 year after the initial evaluation. The spectrum of pediatric interstitial lung disease includes a large, heterogeneous group of rare disorders associated with high morbidity and mortality rates. C1 UNIV COLORADO, HLTH SCI CTR, DEPT PEDIAT, DENVER, CO 80262 USA. BROOKE ARMY MED CTR, DEPT PEDIAT, FT SAM HOUSTON, TX 78234 USA. RP FAN, LL (reprint author), NATL JEWISH CTR IMMUNOL & RESP MED, DIV PEDIAT PULM, 1400 JACKSON, DENVER, CO 80206 USA. FU NHLBI NIH HHS [SCOR I P50 HL 46481-01] NR 33 TC 68 Z9 78 U1 0 U2 0 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0022-3476 EI 1097-6833 J9 J PEDIATR-US JI J. Pediatr. PD DEC PY 1992 VL 121 IS 6 BP 867 EP 872 DI 10.1016/S0022-3476(05)80330-0 PG 6 WC Pediatrics SC Pediatrics GA KB651 UT WOS:A1992KB65100006 PM 1447647 ER PT J AU HSU, FL RAY, R CLARK, OE MUNAVALLI, S ASHMAN, WP AF HSU, FL RAY, R CLARK, OE MUNAVALLI, S ASHMAN, WP TI SYNTHESIS AND ANTICHOLINESTERASE ACTIVITY OF NEW BISPYRIDINIUM COMPOUNDS SO JOURNAL OF PHARMACEUTICAL SCIENCES LA English DT Article ID ACETYLCHOLINESTERASE; CHROMATOGRAPHY; LIGANDS; SYSTEM AB Synthesis of new bis(1-methylpyridinium) compounds containing a 1,4-diacetylbenzene linkage between the pyridinium moieties from commercially available 2-, 3-, and 4-picoline precursors was accomplished via metallation, reaction of the picolyllithium with 1,4-dicyanobenzene, and subsequent quaternization of the resulting bispyridyl compounds. Acetylcholinesterase inhibitory activity was determined colorimetrically with purified electric eel enzyme. Examination of structure-activity relationships indicated that the 3-substituted pyridinium compound is the most potent isomer, followed by the 2-substituted isomer, and that the 4-substituted analogue is the least active. C1 USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010. RP HSU, FL (reprint author), USA,CTR CHEM RES DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010, USA. NR 27 TC 0 Z9 0 U1 0 U2 0 PU AMER PHARMACEUTICAL ASSN PI WASHINGTON PA 2215 CONSTITUTION AVE NW, WASHINGTON, DC 20037 SN 0022-3549 J9 J PHARM SCI JI J. Pharm. Sci. PD DEC PY 1992 VL 81 IS 12 BP 1181 EP 1184 DI 10.1002/jps.2600811211 PG 4 WC Chemistry, Medicinal; Chemistry, Multidisciplinary; Pharmacology & Pharmacy SC Pharmacology & Pharmacy; Chemistry GA KA910 UT WOS:A1992KA91000010 PM 1491336 ER PT J AU GORDON, RK GRAY, RR REAVES, CB BUTLER, DL CHIANG, PK AF GORDON, RK GRAY, RR REAVES, CB BUTLER, DL CHIANG, PK TI INDUCED RELEASE OF ACETYLCHOLINE FROM GUINEA-PIG ILEUM LONGITUDINAL MUSCLE MYENTERIC-PLEXUS BY ANATOXIN-A SO JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS LA English DT Article ID NICOTINIC PHARMACOLOGY; RAT PHEOCHROMOCYTOMA; SUBSTANCE-P; RECEPTORS; ANALOGS; MODULATION; INTESTINE; GASTRIN; NEURONS; SITES AB Anatoxin-a (ANTX), a nicotinic agonist, has been shown to induce contraction of guinea pig ileum, which was abrogated by the muscarinic antagonist atropine and the nicotinic antagonists tubocurarine and hexamethonium. We showed here that the ganglionic nicotinic antagonist mecamylamine was a better inhibitor of the contraction of ileum induced by ANTX. The sodium channel blocker tetrodotoxin also abolished ANTX-induced contraction. In contrast, alpha-bungarotoxin, the muscle type nicotinic receptor blocker, had no effect on ANTX-induced contraction of guinea pig ileum. Longitudinal muscle-myenteric plexus prepared from guinea pig ileum, labeled with [H-3]choline and then incubated with ANTX was shown for the first time to release [H-3]acetylcholine (ACh) in a dose-dependent manner. Pretreatment of longitudinal muscle-myenteric plexus with tubocurarine, hexamethonium or mecamylamine blocked ANTX-induced release of [H-3]ACh. In contrast, atropine was without effect. Mecamylamine was the most potent antagonist. As observed in ileum contraction, tetrodotoxin completely and potently blocked the release of [H-3]ACh induced by ANTX. Neither alpha-bungarotoxin nor the neuromuscular junction blockers conotoxin G1 or M1 could inhibit the [H-3]ACh release. Taken together, these results suggested that ANTX activated nicotinic receptors on ganglionic interneurons to trigger a release of ACh, which next stimulated muscarinic receptors and induced ileum contraction. RP GORDON, RK (reprint author), WALTER REED ARMY INST RES,DIV BIOCHEM,DEPT APPL BIOCHEM,WASHINGTON,DC 20307, USA. NR 31 TC 9 Z9 9 U1 1 U2 6 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-3565 J9 J PHARMACOL EXP THER JI J. Pharmacol. Exp. Ther. PD DEC PY 1992 VL 263 IS 3 BP 997 EP 1002 PG 6 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA KD194 UT WOS:A1992KD19400014 PM 1469655 ER PT J AU SCHUMM, WR AF SCHUMM, WR TI COMMENTS FROM A SYMBOLIC-INTERACTION PERSPECTIVE ON LAKHANI RETENTION COST-BENEFIT-ANALYSIS OF UNITED-STATES-ARMY JUNIOR OFFICERS - A MULTIDISCIPLINARY ANALYSIS SO JOURNAL OF POLITICAL & MILITARY SOCIOLOGY LA English DT Article AB Lakhani's (1991) analysis of the retention intentions of junior officers in the U.S. Army is reviewed from a symbolic interaction and participant observer perspective. Several recommendations for an improved analysis of the data are presented as derived from symbolic interaction interpretations. C1 USA,RES INST,WASHINGTON,DC 20310. RP SCHUMM, WR (reprint author), KANSAS STATE UNIV AGR & APPL SCI,DEPT HUMAN DEV & FAMILY STUDIES,MANHATTAN,KS 66506, USA. NR 2 TC 0 Z9 0 U1 0 U2 0 PU JOURNAL POLITICAL MILITARY SOCIOLOGY PI DE KALB PA DEPT SOCIOLOGY, NORTHERN ILLINOIS UNIV, DE KALB, IL 60115-2854 SN 0047-2697 J9 J POLIT MIL SOCIOL JI J. Polit. Mil. Soc. PD WIN PY 1992 VL 20 IS 2 BP 323 EP 326 PG 4 WC Political Science; Sociology SC Government & Law; Sociology GA KY489 UT WOS:A1992KY48900008 ER PT J AU LAKHANI, H AF LAKHANI, H TI SYMBOLIC-INTERACTION THEORY AND PARTICIPANT OBSERVER PERSPECTIVE - REPLY SO JOURNAL OF POLITICAL & MILITARY SOCIOLOGY LA English DT Editorial Material AB The problem of personal bias in symbolic interaction theory and participant observer perspective is outlined. The bias of Dr. Schumm, a Reserve officer, appears in his suggestions to analyze: (1) intention to join Reserve Guard service instead of retention, (2) retention in Regular Army (RA) versus United States Army Reserve (USAR) instead of the four sources of commissioning analyzed by me. The bias is also manifest in his assertions that I should say that (ROTC) ''officers can only be retained if retirement policies for USAR officers are changed,'' even if I do not have any retirement policy variable in my model. RP LAKHANI, H (reprint author), USA,RES INST,WASHINGTON,DC 20310, USA. NR 3 TC 0 Z9 0 U1 0 U2 0 PU JOURNAL POLITICAL MILITARY SOCIOLOGY PI DE KALB PA DEPT SOCIOLOGY, NORTHERN ILLINOIS UNIV, DE KALB, IL 60115-2854 SN 0047-2697 J9 J POLIT MIL SOCIOL JI J. Polit. Mil. Soc. PD WIN PY 1992 VL 20 IS 2 BP 327 EP 331 PG 5 WC Political Science; Sociology SC Government & Law; Sociology GA KY489 UT WOS:A1992KY48900009 ER PT J AU LAMBERT, RJ AF LAMBERT, RJ TI NO MUSS, NO FUSS IRREVERSIBLE HYDROCOLLOID IMPRESSIONS SO JOURNAL OF PROSTHETIC DENTISTRY LA English DT Note RP LAMBERT, RJ (reprint author), USA,DENT CORPS,FT SAM HOUSTON,TX 78234, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0022-3913 J9 J PROSTHET DENT JI J. Prosthet. Dent. PD DEC PY 1992 VL 68 IS 6 BP 983 EP 983 DI 10.1016/0022-3913(92)90564-Q PG 1 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA KB463 UT WOS:A1992KB46300024 PM 1494133 ER PT J AU DEBOER, J VERHOEF, D AF DEBOER, J VERHOEF, D TI IMPLANT DENTURE MODIFICATION WITH LIGHT-ACTIVATED DENTURE RESIN SO JOURNAL OF PROSTHETIC DENTISTRY LA English DT Note RP DEBOER, J (reprint author), USA DENTAC,COMBINED PROSTHODONT RESIDENCY TRAINING PROGRAM,FT BLISS,TX 79920, USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0022-3913 J9 J PROSTHET DENT JI J. Prosthet. Dent. PD DEC PY 1992 VL 68 IS 6 BP 984 EP 985 DI 10.1016/0022-3913(92)90566-S PG 2 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA KB463 UT WOS:A1992KB46300026 PM 1494135 ER PT J AU APT, C HURLBERT, DF AF APT, C HURLBERT, DF TI THE FEMALE SENSATION SEEKER AND MARITAL SEXUALITY SO JOURNAL OF SEX & MARITAL THERAPY LA English DT Article ID SEEKING; PERSONALITY; AROUSABILITY; EXPERIENCE; ADJUSTMENT; INVENTORY; WOMEN AB To examine the role of sensation seeking in female sexuality, the Zuckerman's Sensation Seeking Scale was administered to a nonclinical population of married women. Comparative assessments were made between two matched samples of high and low sensation seekers on frequency of sexual intercourse, marital satisfaction, sexual desire, sexual arousal, sexual assertiveness, sexual attitudes, and sexual satisfaction. Although the high sensation seekers demonstrated significantly greater sexual desire, sexual arousability, and a more positive attitude toward sex, there were surprisingly no differences between the groups on frequency of sexual intercourse and sexual assertiveness. Also, the women classed as low sensation seekers reported greater marital and sexual satisfaction. C1 USA,WASHINGTON,DC 20310. NR 23 TC 9 Z9 9 U1 2 U2 3 PU BRUNNER/MAZEL INC PI NEW YORK PA 19 UNION SQUARE WEST, NEW YORK, NY 10003 SN 0092-623X J9 J SEX MARITAL THER JI J. Sex Marital Ther. PD WIN PY 1992 VL 18 IS 4 BP 315 EP 324 PG 10 WC Psychology, Clinical; Family Studies SC Psychology; Family Studies GA KE101 UT WOS:A1992KE10100006 PM 1291702 ER PT J AU SMITH, KJ SKELTON, HG FRISSMAN, DM ANGRITT, P AF SMITH, KJ SKELTON, HG FRISSMAN, DM ANGRITT, P TI VERRUCOUS LESIONS SECONDARY TO DNA VIRUSES IN PATIENTS INFECTED WITH THE HUMAN-IMMUNODEFICIENCY-VIRUS IN ASSOCIATION WITH INCREASED FACTOR-XIIIA POSITIVE DERMAL DENDRITIC CELLS SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Article ID ORAL HAIRY LEUKOPLAKIA; SYNDROME AIDS; DENDROCYTES; MANIFESTATIONS; INVOLVEMENT; FIBROBLASTS; PSORIASIS; TUMOR AB Background. Hyperkeratotic lesions caused by varicella-zoster, herpes simplex, or cytomegalovirus occur in patients infected with human immunodeficiency virus type 1 (HIV-1). We have also observed this type of lesion with molluscum contagiosum. Objectives. These cases were studied to determine whether there are any pathologic changes unique to these lesions. Methods: The cases were studied by routine microscopic examination and immunohistochemistry. Results: Each case showed changes diagnostic of the viral infection, which was confirmed by immunohistochemical stains for herpes simplex and cytomegalovirus. In the dermis there were fewer inflammatory cells than expected, but there was an increase in factor XIIIa-positive dendritic cells. Conclusion: Varicella-zoster, herpes simplex virus, cytomegalovirus, and molluscum contagiosum can cause verrucous lesions in HIV-1-infected patients. These lesions may be related to an increase in factor XIIIa-positive dendritic cells. C1 ARMED FORCES INST PATHOL,DEPT DERMATOPATHOL,WASHINGTON,DC 20306. RP SMITH, KJ (reprint author), WALTER REED ARMY INST RES,WASHINGTON,DC 20307, USA. FU NIAMS NIH HHS [Y01AR00014, Y01AR90008] NR 40 TC 38 Z9 38 U1 0 U2 1 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD DEC PY 1992 VL 27 IS 6 BP 943 EP 950 DI 10.1016/0190-9622(92)70291-M PN 1 PG 8 WC Dermatology SC Dermatology GA KB217 UT WOS:A1992KB21700006 PM 1362209 ER PT J AU ROY, A SCHILLING, PJ EATON, HC MALONE, PG BRABSTON, WN WAKELEY, LD AF ROY, A SCHILLING, PJ EATON, HC MALONE, PG BRABSTON, WN WAKELEY, LD TI ACTIVATION OF GROUND BLAST-FURNACE SLAG BY ALKALI-METAL AND ALKALINE-EARTH HYDROXIDES SO JOURNAL OF THE AMERICAN CERAMIC SOCIETY LA English DT Article AB The effects of pH, time, valence, and radius of the activator cation on the reaction products and microstructure of ground granulated iron blast-furnace slag were studied by thermogravimetry and derivative thermogravimetry, X-ray diffractometry, scanning electron microscopy, and energy dispersive X-ray microanalysis. Blast-furnace slag was activated by alkali-metal hydroxides of Li, Na, and K (12.34 less-than-or-equal-to pH less-than-or-equal-to 14.71) and alkaline-earth hydroxides of Ca, Sr, and Ba (12.47 less-than-or-equal-to pH less-than-or-equal-to 13.53) using a water/slag ratio of 0.4 and curing for 1 day to 26 months. Reactivity of the slag was more strongly dependent on pH than on time. The reaction products were mainly varieties of C-S-H, (C,M)4AH13, and minor amounts of Ca(OH)2 and C2ASH8 (stratlingite). The nature of C-S-H was dependent on pH. A 1.2-nm peak appeared in X-ray diffractograms only when the activation pH was almost-equal-to 14.7. Water was present in the C-S-H in a way similar to water in tobermorite and synthetic C-S-H. Leached Ca from unreacted blast-furnace slag was present around the glass particles as an amorphous layer which crystallized into Ca(OH)2 with time; Mg behaved similarly. The effect of the charge or ionic radius of the activator cation was insignificant. C1 LOUISIANA STATE UNIV,COLL ENGN,BATON ROUGE,LA 70803. USA,WATERWAYS EXPT STN,VICKSBURG,MS 39180. RP EATON, HC (reprint author), LOUISIANA STATE UNIV,COLL ENGN,BATON ROUGE,LA 70803, USA. NR 25 TC 31 Z9 31 U1 1 U2 8 PU AMER CERAMIC SOC PI WESTERVILLE PA 735 CERAMIC PLACE, PO BOX 6136, WESTERVILLE, OH 43081-6136 SN 0002-7820 J9 J AM CERAM SOC JI J. Am. Ceram. Soc. PD DEC PY 1992 VL 75 IS 12 BP 3233 EP 3240 DI 10.1111/j.1151-2916.1992.tb04416.x PG 8 WC Materials Science, Ceramics SC Materials Science GA KC291 UT WOS:A1992KC29100006 ER PT J AU COLLIER, BW SOLBERG, VB BROWN, MW BOOBAR, LR AF COLLIER, BW SOLBERG, VB BROWN, MW BOOBAR, LR TI A FABRIC BODY LIGHT TRAP FOR SAMPLING MOSQUITOS SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Note AB A Fabric Body light trap has been developed that has unique features of a cloth body, folding rainshield and a modified folding net. These features allow the light trap to be reduced in size and weight for transportation and storage while retaining the same operational characteristics as the Solid State Army Miniature (SSAM) light trap. C1 USA,BIOMED RES & DEV LAB,FREDERICK,MD 21702. RP COLLIER, BW (reprint author), OL AL,OET,BLDG 79,AREA B,WRIGHT PATTERSON AFB,DAYTON,OH 45433, USA. NR 3 TC 1 Z9 1 U1 0 U2 0 PU AMER MOSQUITO CONTROL ASSN INC PI LAKE CHARLES PA 707-A EAST PRIEN LAKE ROAD, PO BOX 5416, LAKE CHARLES, LA 70606-5416 SN 8756-971X J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD DEC PY 1992 VL 8 IS 4 BP 413 EP 415 PG 3 WC Entomology SC Entomology GA KT606 UT WOS:A1992KT60600013 PM 1361941 ER PT J AU SHERIDAN, RL RUE, LW MCMANUS, WF PRUITT, BA AF SHERIDAN, RL RUE, LW MCMANUS, WF PRUITT, BA TI BURNS IN MORBIDLY OBESE PATIENTS SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article AB It has been estimated that 26% of Americans are obese. A very small subset of this group can be categorized as morbidly obese, fulfilling the criteria of being 100 pounds, or 100%, over ideal body weight. The clinical records of seven morbidly obese burn patients treated over a 20-year period are reviewed. Particularly notable was a 43% incidence of fatal pulmonary embolism. RP SHERIDAN, RL (reprint author), USA,INST SURG RES,FT SAM HOUSTON,TX 78234, USA. NR 9 TC 16 Z9 16 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 1079-6061 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD DEC PY 1992 VL 33 IS 6 BP 818 EP 820 DI 10.1097/00005373-199212000-00004 PG 3 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA KF879 UT WOS:A1992KF87900004 PM 1474621 ER PT J AU PHILLIPS, TH ZEIDMAN, EJ THOMPSON, IM AF PHILLIPS, TH ZEIDMAN, EJ THOMPSON, IM TI THE FATE OF BURIED VAGINAL EPITHELIUM SO JOURNAL OF UROLOGY LA English DT Article DE EPITHELIUM; URINARY INCONTINENCE; VAGINA ID URINARY-INCONTINENCE AB A new technique in the treatment of stress urinary incontinence utilizes a sling fashioned from a rectangular island of buried vaginal epithelium. We developed a model to study the natural history of vaginal wall covered by an epithelial flap in 12 rabbits sacrificed at intervals to 26 weeks. Histopathologic examination demonstrated an immediate acute inflammatory reaction. This early response was followed by formation of an epithelial lining of the potential space overlying the buried vaginal tissue. Acute inflammatory cells continued to enter this lumen until week 20, when granulomas were first detected. Histopathologic examination at twenty-six weeks showed stratified squamous epithelium lining the lumen. No deleterious inflammatory sequelae were detected, and no dysplastic or malignant changes were identified. These results suggest that buried vaginal epithelium is a safe (short term) tissue alternative for sling creation. C1 BROOKE ARMY MED CTR,UROL SURG SERV,FT SAM HOUSTON,TX 78234. WILFORD HALL USAF MED CTR,SAN ANTONIO,TX. NR 7 TC 6 Z9 6 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-5347 J9 J UROLOGY JI J. Urol. PD DEC PY 1992 VL 148 IS 6 BP 1941 EP 1943 PG 3 WC Urology & Nephrology SC Urology & Nephrology GA JZ904 UT WOS:A1992JZ90400073 PM 1433650 ER PT J AU HANSEN, BD NARA, PL MAHESHWARI, RK SIDHU, GS BERNBAUM, JG HOEKZEMA, D MELTZER, MS GENDELMAN, HE AF HANSEN, BD NARA, PL MAHESHWARI, RK SIDHU, GS BERNBAUM, JG HOEKZEMA, D MELTZER, MS GENDELMAN, HE TI LOSS OF INFECTIVITY BY PROGENY VIRUS FROM ALPHA-INTERFERON-TREATED HUMAN-IMMUNODEFICIENCY-VIRUS TYPE 1-INFECTED T-CELLS IS ASSOCIATED WITH DEFECTIVE ASSEMBLY OF ENVELOPE GP120 SO JOURNAL OF VIROLOGY LA English DT Note ID VESICULAR STOMATITIS-VIRUS; KAPOSIS SARCOMA; HIV REPLICATION; PARTICLES; ACCUMULATION; MECHANISMS; HEMOPHILIA; INHIBITION; MONOCYTES; PROTEINS AB Levels of human immunodeficiency virus (HIV) DNA, RNA, or p24 antigen and reverse transcriptase activity in T-cell cultures treated with 500 IU of recombinant alpha interferon (rIFNalpha) per ml were comparable to those in control cultures. Radioimmunoprecipitation analysis of proteins in lysates of IFN-treated T cells documented a marked accumulation of HIV proteins. Localization of gp120 by immunofluorescence showed a diffuse pattern in IFN-treated cells quite distinct from the ring pattern in untreated control cells. That large quantities of gp120 in aberrant cell compartments might affect HIV morphogenesis was confirmed in infectivity studies: virions from IFN-treated cells were 100- to 1,000-fold less infectious than an equal number of virions from control cells. Direct examination of IFN-treated and control HIV-infected cells by transmission electron microscopy showed little difference in the number or distribution of viral particles. However, quantitation of gp120 by immunogold particle analysis revealed a marked depletion of envelope glycoprotein in virions released from IFN-treated cells. This defect in gp120 assembly onto mature viral particles provides a molecular basis for this loss of infectivity. C1 NCI,FREDERICK CANC RES FACIL,TUMOR CELL BIOL LAB,FREDERICK,MD 21701. UNIFORMED SERV UNIV HLTH SCI,DEPT PATHOL,BETHESDA,MD 20814. ADV BIOTECHNOL INC,COLUMBIA,MD 21046. HENRY M JACKSON FDN ADV MIL MED,ROCKVILLE,MD 20850. RP HANSEN, BD (reprint author), WALTER REED ARMY INST RES,DEPT CELLULAR IMMUNOL,WASHINGTON,DC 20307, USA. NR 36 TC 63 Z9 65 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0022-538X J9 J VIROL JI J. Virol. PD DEC PY 1992 VL 66 IS 12 BP 7543 EP 7548 PG 6 WC Virology SC Virology GA JY710 UT WOS:A1992JY71000088 PM 1279206 ER PT J AU MUNDIE, TG DODD, KT LAGUTCHIK, M AF MUNDIE, TG DODD, KT LAGUTCHIK, M TI RELATIONSHIP OF FUNCTIONAL RESIDUAL CAPACITY TO VARIOUS BODY MEASUREMENTS IN NORMAL SHEEP SO LABORATORY ANIMAL SCIENCE LA English DT Article ID CONSCIOUS SHEEP; LUNG-MECHANICS; AIRWAY REACTIVITY AB Functional residual capacity (FRC) was determined by nitrogen washout in 55 normal sheep. Data on various external body measurements were collected which included body weight, chest circumference, chest width, body length, height, and sternum length. In addition, data on wet lung weight and wet lung weight/body weight ratio were collected on 10 of the sheep. A significant correlation was found between FRC and all measured parameters except height and sternum length. Multiple linear regression of all external body measurements showed the best correlation of FRC to body weight and body length, while the addition of chest circumference and/or chest width did not significantly improve the correlation. Significant deviation from the population was noted in three sheep (5.5%) that had lung weight/body weight ratios which were significantly lower than the rest of the population. C1 WALTER REED ARMY INST RES,DEPT RESP RES,DIV MED,WASHINGTON,DC 20307. NR 18 TC 6 Z9 6 U1 0 U2 0 PU AMER ASSOC LABORATORY ANIMAL SCIENCE PI CORDOVA PA 70 TIMBERCREEK DR, SUITE 5, CORDOVA, TN 38018 SN 0023-6764 J9 LAB ANIM SCI JI Lab. Anim. Sci. PD DEC PY 1992 VL 42 IS 6 BP 589 EP 592 PG 4 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA KE139 UT WOS:A1992KE13900011 PM 1479812 ER PT J AU KIM, KS WASS, CA CROSS, AS OPAL, SM AF KIM, KS WASS, CA CROSS, AS OPAL, SM TI MODULATION OF BLOOD-BRAIN-BARRIER PERMEABILITY BY TUMOR-NECROSIS-FACTOR AND ANTIBODY TO TUMOR-NECROSIS-FACTOR IN THE RAT SO LYMPHOKINE AND CYTOKINE RESEARCH LA English DT Article ID VASCULAR ENDOTHELIAL-CELLS; PLATELET-ACTIVATING FACTOR; BACTERIAL-MENINGITIS; CEREBROSPINAL-FLUID; B MENINGITIS; FACTOR-ALPHA; INTERLEUKIN-1; INFLAMMATION; INVIVO; BBBP AB In an attempt to understand the role of TNF in the central nervous system (CNS) pathophysiologic events associated with bacterial meningitis, we examined the effect of intravenous vs. intracisternal administration of TNF alpha on penetration of circulating I-125-labeled albumin into cerebrospinal fluid (CSF) and CSF white blood cell (WBC) counts in rats. Intracisternal administration of tumor necrosis factor alpha (TNF-alpha) resulted in dose- and time-dependent alterations of the CSF penetration and CSF WBCs, while intravenous administration of TNF-alpha did not induce any changes. These changes by intracisternal TNF were abolished by heat treatment of TNF or coadministration of MAb to TNF-alpha. Mab to TNF-alpha also significantly reduced the CSF penetration of circulating albumin in experimental hematogenous Haemophilus influenzae type b meningitis in infant rats but this salutary effect required both intravenous and intracisternal administration. However, MAb to TNF-alpha failed to affect CSF pleocytosis in experimental hematogenous meningitis. These findings suggest that some of CNS pathophysiologic changes in bacterial meningitis may be a result of the local production of TNF but other host inflammatory responses may also participate in CNS inflammation in hematogenous bacterial meningitis. C1 MEM HOSP RHODE ISL,DEPT MED,PAWTUCKET,RI 02860. WALTER REED ARMY INST RES,DEPT BACTERIAL DIS,WASHINGTON,DC 20307. RP KIM, KS (reprint author), USC,CHILDRENS HOSP LOS ANGELES,SCH MED,DEPT PEDIAT,DIV INFECT DIS,4650 SUNSET BLVD,BOX 51,LOS ANGELES,CA 90027, USA. FU NINDS NIH HHS [R01 NS-26310] NR 28 TC 121 Z9 121 U1 1 U2 3 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0277-6766 J9 LYMPHOKINE CYTOK RES JI Lymphokine Cytokine Res. PD DEC PY 1992 VL 11 IS 6 BP 293 EP 298 PG 6 WC Biochemistry & Molecular Biology; Immunology SC Biochemistry & Molecular Biology; Immunology GA LC426 UT WOS:A1992LC42600002 PM 1477182 ER PT J AU KRATOCHVIL, G FENNER, T BENSON, R AF KRATOCHVIL, G FENNER, T BENSON, R TI SIR TECHNOLOGY HELPS ENSURE SAFE LANDINGS FOR NASA SO MATERIALS EVALUATION LA English DT Article C1 GEOPHYS SURVEY SYST INC,N SALEM,NH. USA,WASHINGTON,DC 20310. TECHNOS INC,MIAMI,FL. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC NON-DESTRUCTIVE TEST PI COLUMBUS PA 1711 ARLINGATE LANE PO BOX 28518, COLUMBUS, OH 43228-0518 SN 0025-5327 J9 MATER EVAL JI Mater. Eval. PD DEC PY 1992 VL 50 IS 12 BP 1412 EP & PG 0 WC Materials Science, Characterization & Testing SC Materials Science GA KD472 UT WOS:A1992KD47200005 ER PT J AU ROLPH, JW AF ROLPH, JW TI FREEDOM OF NAVIGATION AND THE BLACK-SEA BUMPING INCIDENT - HOW INNOCENT MUST INNOCENT PASSAGE BE SO MILITARY LAW REVIEW LA English DT Article ID LAW RP ROLPH, JW (reprint author), USA,JUDGE ADVOCATE GEN SCH,DIV INT LAW,CHARLOTTESVILLE,VA 22901, USA. NR 49 TC 7 Z9 7 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD WIN PY 1992 VL 135 BP 137 EP 165 PG 29 WC Law SC Government & Law GA HB541 UT WOS:A1992HB54100004 ER PT J AU BORCH, FL AF BORCH, FL TI GALILEO REVENGE - JUNK SCIENCE IN THE COURTROOM - HUBER,PW SO MILITARY LAW REVIEW LA English DT Book Review RP BORCH, FL (reprint author), USA,JUDGE ADVOCATE GEN SCH,DIV CRIMINAL LAW,CHARLOTTESVILLE,VA 22901, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD WIN PY 1992 VL 135 BP 195 EP 198 PG 4 WC Law SC Government & Law GA HB541 UT WOS:A1992HB54100006 ER PT J AU BORCH, FL AF BORCH, FL TI OTHER LOSSES - RACQUE,J SO MILITARY LAW REVIEW LA English DT Book Review RP BORCH, FL (reprint author), USA,JUDGE ADVOCATE GEN SCH,DIV CRIMINAL LAW,CHARLOTTESVILLE,VA 22901, USA. NR 1 TC 1 Z9 1 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD WIN PY 1992 VL 135 BP 198 EP 201 PG 4 WC Law SC Government & Law GA HB541 UT WOS:A1992HB54100007 ER PT J AU WOHLHIETER, J AF WOHLHIETER, J TI SUMMARY REPORT - WORKSHOP ON ANIMAL-MODELS OF HUMAN-IMMUNODEFICIENCY-VIRUS INFECTIONS IN HUMANS SO MILITARY MEDICINE LA English DT Article RP WOHLHIETER, J (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DIV RETROVIROL,WASHINGTON,DC 20307, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD DEC PY 1992 VL 157 IS 12 BP 662 EP 664 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA KB925 UT WOS:A1992KB92500021 PM 1470380 ER PT J AU LOWRY, MA MCEVOY, PL AF LOWRY, MA MCEVOY, PL TI DERMATOBIA-HOMINIS INFESTATION - A CASE-REPORT SO MILITARY MEDICINE LA English DT Article AB The hazards presented by the Central American tropical environment are myriad. We report a case of cutaneous myiasis caused by the human botfly, Dermatobia hominis, in a soldier who had participated in military operations in Central America The clinical presentation, treatment, and unique life cycle of the human botfly is discussed. RP LOWRY, MA (reprint author), WALTER REED ARMY MED CTR,DEPT PATHOL,MICROBIOL SECT,WASHINGTON,DC 20307, USA. NR 0 TC 8 Z9 8 U1 0 U2 2 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD DEC PY 1992 VL 157 IS 12 BP 683 EP 684 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA KB925 UT WOS:A1992KB92500028 PM 1470387 ER PT J AU REUSS, M AF REUSS, M TI HISTORICAL-ANALYSIS AND WATER-RESOURCES DEVELOPMENT - FOREWORD SO NATURAL RESOURCES JOURNAL LA English DT Editorial Material RP REUSS, M (reprint author), USA, CORP ENGINEERS, OFF HIST, WASHINGTON, DC 20310 USA. NR 12 TC 0 Z9 0 U1 0 U2 0 PU UNIV NEW MEXICO, SCH LAW PI ALBUQUERQUE PA MSC11-6070, 1 UNIVERSITY NEW MEXICO, ALBUQUERQUE, NM 87131 USA SN 0028-0739 J9 NAT RESOUR J JI Nat. Resour. J. PD WIN PY 1992 VL 32 IS 1 BP 1 EP 4 PG 4 WC Environmental Studies; Law SC Environmental Sciences & Ecology; Government & Law GA JH035 UT WOS:A1992JH03500001 ER PT J AU REUSS, M AF REUSS, M TI COPING WITH UNCERTAINTY - SOCIAL-SCIENTISTS, ENGINEERS, AND FEDERAL WATER-RESOURCES PLANNING SO NATURAL RESOURCES JOURNAL LA English DT Article AB The growing popularity of multipurpose water management-encouraged by a great many engineers- in the early 20th century led to the call for severely rationalist studies of regional social and physical characteristics. To analyze what, where, and when multipurpose projects were needed, the federal government hired economists, geographers, and political scientists. "Planning" became the watchword, and by 1965 that activity occupied a sizable number of social and physical scientists in the federal government. Since passage of the National Environmental Policy Act in 1969, with its requirement for environmental impact statements, natural scientists also have become an important part of water resources planning for they must determine both immediate and long-term environmental impacts. The net result of these changes is that the role of the engineer has changed in the planning process. This, in turn, has contributed to changes in organizational culture and focus. This article examines and evaluates the evolving water resources planning process and shows how that process has affected professional and organizational relationships, the design of water projects, and the theory of water management. RP REUSS, M (reprint author), USA,CORP ENGINEERS,OFF HIST,WASHINGTON,DC 20310, USA. NR 150 TC 10 Z9 10 U1 0 U2 0 PU UNIV NEW MEXICO PI ALBUQUERQUE PA SCHOOL OF LAW 1117 STANFORD N E, ALBUQUERQUE, NM 87131 SN 0028-0739 J9 NAT RESOUR J JI Nat. Resour. J. PD WIN PY 1992 VL 32 IS 1 BP 101 EP 135 PG 35 WC Environmental Studies; Law SC Environmental Sciences & Ecology; Government & Law GA JH035 UT WOS:A1992JH03500006 ER PT J AU REUSS, M AF REUSS, M TI CONGRESS IN ITS WISDOM - THE BUREAU OF RECLAMATION AND THE PUBLIC-INTEREST - DAWDY,DO SO NATURAL RESOURCES JOURNAL LA English DT Book Review RP REUSS, M (reprint author), USA,CORP ENGINEERS,OFF HIST,WASHINGTON,DC 20310, USA. NR 1 TC 0 Z9 0 U1 0 U2 1 PU UNIV NEW MEXICO PI ALBUQUERQUE PA SCHOOL OF LAW 1117 STANFORD N E, ALBUQUERQUE, NM 87131 SN 0028-0739 J9 NAT RESOUR J JI Nat. Resour. J. PD WIN PY 1992 VL 32 IS 1 BP 206 EP 209 PG 4 WC Environmental Studies; Law SC Environmental Sciences & Ecology; Government & Law GA JH035 UT WOS:A1992JH03500011 ER PT J AU SHANLEY, DJ AF SHANLEY, DJ TI BILATERAL ABERRANT CERVICAL INTERNAL CAROTID ARTERIES SO NEURORADIOLOGY LA English DT Article DE INTERNAL CAROTID ARTERY; COMPUTED TOMOGRAPHY; MAGNETIC RESONANCE IMAGING; MAGNETIC RESONANCE ANGIOGRAPHY AB A patient with symptomatic bilateral aberrant cervical internal carotid arteries, demonstrated on CT and MRI, is described. RP SHANLEY, DJ (reprint author), TRIPLER ARMY MED CTR,DEPT RADIOL,HONOLULU,HI 96859, USA. NR 7 TC 7 Z9 8 U1 0 U2 0 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0028-3940 J9 NEURORADIOLOGY JI Neuroradiology PD DEC PY 1992 VL 35 IS 1 BP 55 EP 56 PG 2 WC Clinical Neurology; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging GA KB911 UT WOS:A1992KB91100011 PM 1289740 ER PT J AU MURRAY, JE HIBBERT, ML HETH, SR LETTERIE, GS AF MURRAY, JE HIBBERT, ML HETH, SR LETTERIE, GS TI A TECHNIQUE FOR LAPAROSCOPIC POMEROY TUBAL-LIGATION WITH ENDOLOOP SUTURES SO OBSTETRICS AND GYNECOLOGY LA English DT Article ID MINILAPAROTOMY STERILIZATION AB A laparoscopic technique of Pomeroy tubal ligation using endoloop sutures was compared with the conventional technique of laparoscopic tubal ligation with Silastic rings. Fifty-three patients selected from a population undergoing tubal ligation were randomized to either the Pomeroy (N = 28) or ring (N = 25) group. Mean (+/- standard deviation) operative time for the Pomeroy group was 27.39 +/- 5.95 minutes, with a range of 18-40; for the ring group, the time was 23.11 +/- 11.53 minutes, with a range of 12-58. These times were not statistically different. Operative complications were encountered only in the ring group and included two lacerations of the mesosalpinx. There were no technical or method failures over a follow-up interval of 12-18 months. Specimens confirmed tubal histology in all cases in the Pomeroy group. Laparoscopic Pomeroy tubal ligation using endoloop sutures was easily performed, comparable to laparoscopic application of Silastic rings, and provided a surgical specimen to confirm tubal histology. This aspect may represent a medicolegal advantage of documentation not available with other laparoscopic techniques of tubal ligation. C1 TRIPLER ARMY MED CTR,DEPT OBSTET & GYNECOL,HONOLULU,HI 96859. NR 9 TC 15 Z9 15 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0029-7844 J9 OBSTET GYNECOL JI Obstet. Gynecol. PD DEC PY 1992 VL 80 IS 6 BP 1053 EP 1055 PG 3 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA KA566 UT WOS:A1992KA56600031 PM 1448251 ER PT J AU HACKER, HD HOLLSTEN, DA AF HACKER, HD HOLLSTEN, DA TI INVESTIGATION OF AUTOMATED PERIMETRY IN THE EVALUATION OF PATIENTS FOR UPPER LID BLEPHAROPLASTY SO OPHTHALMIC PLASTIC AND RECONSTRUCTIVE SURGERY LA English DT Article DE BLEPHAROPLASTY; DERMATOCHALASIS; PERIMETRY; VISUAL FIELD; MARGIN REFLEX DISTANCE AB We investigated the application of automated perimetry in the evaluation of 17 patients for upper lid blepharoplasty. Visual fields were assessed by a 114 point threshold related screening test of the superior visual field on the Humphrey Allergan Model 640 visual field analyzer. Patients enrolled in the study underwent a complete oculoplastic evaluation prior to and at 4-6 weeks after their procedure. Postoperatively, the visual field as measured by the number of points seen, increased by 26.2% (p < 0.000001). Improvement in visual field results was most dramatic in patients whose margin reflex distance (MRD) was less-than-or-equal-to 3.5 mm. This effect was related to excision of redundant eyelid tissue rather than a change in MRD after blepharoplasty. Above this MRD level, blepharoplasty did not significantly improve the patients superior visual field. These results suggest that automated perimetry provides valuable information to document visual field changes for medicolegal and insurance purposes. C1 BROOKE ARMY MED CTR,OPHTHALMOL SERV,DEPT SURG,FT SAM HOUSTON,TX 78234. NR 0 TC 14 Z9 14 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0740-9303 J9 OPHTHALMIC PLAST REC JI Ophthalmic Plast. Reconstr. Surg. PD DEC PY 1992 VL 8 IS 4 BP 250 EP 255 DI 10.1097/00002341-199212000-00003 PG 6 WC Ophthalmology; Surgery SC Ophthalmology; Surgery GA KB037 UT WOS:A1992KB03700003 PM 1476973 ER PT J AU SIMS, SRF DASARATHY, BV AF SIMS, SRF DASARATHY, BV TI AUTOMATIC TARGET RECOGNITION USING A PASSIVE MULTISENSOR SUITE SO OPTICAL ENGINEERING LA English DT Article DE AUTOMATIC TARGET RECOGNITION; MULTISENSOR FUSION; PASSIVE SENSOR PROCESSING; GENETIC ALGORITHM ID FEATURE-SELECTION; FUSION AB An ongoing study of automatic target recognition using a passive multisensor suite is presented. The multisensor suite consists of electro-optical and acoustic sensors, a radio frequency interferometer, and meteorological sensors. Three feature analysis tools-a genetic algorithm, a branch-and-bound algorithm, and a new class overlap region partitioning scheme (CORPS)-are employed for assessing the effectiveness of features extracted by several data and feature fusion concepts. Dedicated hardware has been configured for laboratory and field testing. A high-resolution graphics display has been designed for monitoring the target-acquisition-related processes and maximizing information transfer to the operator. C1 DYNET INC,HUNTSVILLE,AL 35814. RP SIMS, SRF (reprint author), USA,MISSILE COMMAND,CTR RES DEV & ENGN,AMSMI RD AS SS,REDSTONE ARSENAL,AL 35898, USA. NR 29 TC 2 Z9 2 U1 0 U2 1 PU SOC PHOTO-OPT INSTRUM ENG PI BELLINGHAM PA PO BOX 10, BELLINGHAM, WA 98227-0010 SN 0091-3286 J9 OPT ENG JI Opt. Eng. PD DEC PY 1992 VL 31 IS 12 BP 2584 EP 2593 DI 10.1117/12.60015 PG 10 WC Optics SC Optics GA KB842 UT WOS:A1992KB84200009 ER PT J AU VANDERGRACHT, J MAIT, JN AF VANDERGRACHT, J MAIT, JN TI INCOHERENT PATTERN-RECOGNITION WITH PHASE-ONLY FILTERS SO OPTICS LETTERS LA English DT Article ID SPATIAL LIGHT-MODULATOR AB Phase-only and binary-phase spatial light modulators can be employed in the filter plane of incoherent pattern recognition systems. We employ computer simulations to show that advanced filter design techniques can be used to achieve a close approximation to classical matched filtering. RP VANDERGRACHT, J (reprint author), USA,RES LAB,2800 POWDER MILL RD,ADELPHI,MD 20783, USA. NR 17 TC 11 Z9 11 U1 1 U2 1 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0146-9592 J9 OPT LETT JI Opt. Lett. PD DEC 1 PY 1992 VL 17 IS 23 BP 1703 EP 1705 DI 10.1364/OL.17.001703 PG 3 WC Optics SC Optics GA JZ935 UT WOS:A1992JZ93500020 PM 19798290 ER PT J AU PATOW, CA AF PATOW, CA TI HUMAN-IMMUNODEFICIENCY-VIRUS ASSOCIATED MALIGNANCIES - DIAGNOSIS, NATURAL-HISTORY, AND MANAGEMENT SO OTOLARYNGOLOGIC CLINICS OF NORTH AMERICA LA English DT Article ID IMMUNE-DEFICIENCY SYNDROME; PNEUMOCYSTIS-CARINII PNEUMONIA; NON-HODGKINS LYMPHOMA; AIDS-RELATED LYMPHOMA; KAPOSIS-SARCOMA; HOMOSEXUAL MEN; CLINICAL CHARACTERISTICS; ORAL CAVITY; THERAPY; EPIDEMIOLOGY C1 UNIFORMED SERV UNIV HLTH SCI,DEPT SURG,BETHESDA,MD 20814. RP PATOW, CA (reprint author), WALTER REED ARMY MED CTR,DEPT OTOLARYNGOL HEAD & NECK SURG,WASHINGTON,DC 20307, USA. NR 81 TC 3 Z9 3 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0030-6665 J9 OTOLARYNG CLIN N AM JI Otolaryngol. Clin. N. Am. PD DEC PY 1992 VL 25 IS 6 BP 1307 EP 1320 PG 14 WC Otorhinolaryngology SC Otorhinolaryngology GA KA780 UT WOS:A1992KA78000010 ER PT J AU COCHRAN, JC THORNE, DR PENETAR, DM NEWHOUSE, PA AF COCHRAN, JC THORNE, DR PENETAR, DM NEWHOUSE, PA TI PARSING ATTENTIONAL COMPONENTS DURING A SIMPLE REACTION-TIME-TASK USING SLEEP-DEPRIVATION AND AMPHETAMINE INTERVENTION SO PERCEPTUAL AND MOTOR SKILLS LA English DT Article ID ACOUSTIC STARTLE; AROUSAL; BARBITURATE; SENSITIVITY; INTENSITY; VARIANCE; REFLEX; RAT AB To examine the independent contributions of the attentional components of arousal and activation in performance, sleep deprivation was used as the attentional manipulation in a reaction time (RT) task. The subjects were 18 men who underwent 63 hr. of sleep deprivation during which time they periodically performed a simple auditory RT task with manipulations of temporal uncertainty and intensity. After 48 hr. sleep deprivation, subjects ingested either 20 mg d-amphetamine or placebo, then continued testing throughout Day 3. During sleep deprivation, performance was more impaired on trials associated with low temporal uncertainty (arousal) and high preparation (activation) than on trials associated with high temporal uncertainty and low preparation. Analysis indicated that sleep deprivation perturbed activation, leaving arousal relatively unimpaired and that amphetamine had a restorative effect on the sleep deprivation-impaired activation system. The stimulus of high intensity was disruptive on Day 1 but facilitative on Day 3, a result which was interpreted as an initial inhibition, then disinhibition of arousal. Results were interpreted to indicate that, in some instances, alterations in the less specific arousal and activation systems may underlie impairment or changes in the more specific information processing and motor output stages. C1 WALTER REED ARMY INST RES,DEPT NEUROPSYCHIAT,WASHINGTON,DC 20307. RI Newhouse, Paul/J-4597-2014 NR 52 TC 12 Z9 12 U1 0 U2 0 PU PERCEPTUAL MOTOR SKILLS PI MISSOULA PA PO BOX 9229, MISSOULA, MT 59807 SN 0031-5125 J9 PERCEPT MOTOR SKILL JI Percept. Mot. Skills PD DEC PY 1992 VL 75 IS 3 BP 675 EP 689 DI 10.2466/PMS.75.7.675-689 PN 1 PG 15 WC Psychology, Experimental SC Psychology GA JW498 UT WOS:A1992JW49800001 PM 1454457 ER PT J AU BAUMAN, RA AF BAUMAN, RA TI THE EFFECTS OF WHEEL RUNNING, A LIGHT DARK CYCLE, AND THE INSTRUMENTAL COST OF FOOD ON THE INTAKE OF FOOD IN A CLOSED ECONOMY SO PHYSIOLOGY & BEHAVIOR LA English DT Article DE CLOSED ECONOMY; WHEEL RUNNING; LIGHT DARK CYCLE; COST OF FOOD; FOOD INTAKE ID ACTIVITY-STRESS ULCER; BEHAVIORAL ECONOMICS; RATS; PATTERNS; DEMAND AB The effects of wheel running on the food intake of rats, and on the extent to which rats defend their daily food intake against increases in the instrumental cost of food, were studied in a closed economy. Rats lived in cages that were attached to running wheels. Within each cage, water was freely available and lever pressing was required for access to food; a fixed number of presses was required for the delivery of a single food pellet. All cages were located in an environmental chamber where a 12-h light/dark cycle was continuously maintained. During stage I, the entrance to each running wheel was blocked and two series (series 1 and 2) of progressively increasing fixed ratios (FRs) of presses per pellet were imposed. Each FR was used for a single day. During stage II, the entrance to each wheel was unblocked and wheel running and food intake were allowed to stabilize. During stage III, the running wheels remained available and the FR was again increased (series 3). In stage I, increases in the FR reduced food intake proportionally more rapidly during the light than during the dark. and this reduction in the light was greater during series 1 than series 2. During stage II, food intake was transiently reduced during the first week of access to running wheels, but recovered by the end of the second week. During stage III, increases in the FR again reduced food intake proportionally more rapidly during the light than during the dark. Wheel running did not affect the extent to which food intake was reduced within light and dark periods. However, as food intake was reduced by increasingly larger FRs, wheel running increased during the light but was unaffected during the dark. This selective increase in wheel running was attributed to the proportionally greater reduction of food intake and, by implication, body weight in the light. RP BAUMAN, RA (reprint author), WALTER REED ARMY INST RES,DEPT MED NEUROSCI,PHYSIOL & BEHAV BRANCH,WASHINGTON,DC 20307, USA. NR 21 TC 19 Z9 19 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0031-9384 J9 PHYSIOL BEHAV JI Physiol. Behav. PD DEC PY 1992 VL 52 IS 6 BP 1077 EP 1083 DI 10.1016/0031-9384(92)90462-B PG 7 WC Psychology, Biological; Behavioral Sciences SC Psychology; Behavioral Sciences GA KB316 UT WOS:A1992KB31600007 PM 1484863 ER PT J AU MCLEAN, S STANLEY, W STERN, H FONDAALLEN, J DEVINE, G ELLINGHAM, T ROSENBAUM, K AF MCLEAN, S STANLEY, W STERN, H FONDAALLEN, J DEVINE, G ELLINGHAM, T ROSENBAUM, K TI PRENATAL-DIAGNOSIS OF PALLISTER-KILLIAN SYNDROME - RESOLUTION OF CYTOGENETIC AMBIGUITY BY USE OF FLUORESCENT INSITU HYBRIDIZATION SO PRENATAL DIAGNOSIS LA English DT Article DE PALLISTER-KILLIAN SYNDROME; ISOCHROMOSOME-12P; FLUORESCENT INSITU HYBRIDIZATION; PRENATAL ID MOSAIC TETRASOMY 12P; ISOCHROMOSOME-12P; CHROMOSOME; I(12P) AB We report a case of Pallister-Killian syndrome initially diagnosed prenatally as tetrasomy 21. A 33-year-old primiparous woman was noted at 24 weeks' gestation to have moderate polyhydramnios. Ultrasonography showed diminished fetal stomach filling, hydronephrosis, and prominence of the cisterna magna. Cytogenetic analysis of cultured amniocytes was initially interpreted as mosaic tetrasomy 21: 46,XX/47,XX,+i(21q). The patient was then referred to our centre for genetic counselling. At 34 weeks' gestation, a dysmorphic infant was delivered and died within 30 min. Physical features were consistent with the Pallister-Killian syndrome. Renal, gastrointestinal, and central nervous system anomalies were found at post-mortem examination. Analysis of peripheral lymphocytes revealed 5 per cent of cells with a marker chromosome, while 92 per cent of cultured fibroblasts had this same marker. Fluorescent in situ hybridization (FISH) using an alpha-satellite probe for chromosomes 13 and 21 failed to hybridize to the marker, while a chromosome 12 centromeric probe unequivocally identified it as an i(12p). Use of FISH can provide rapid, specific prenatal diagnosis of ambiguous marker chromosomes and improve prenatal counselling. C1 CHILDREN NATL MED CTR,DEPT LAB MED,WASHINGTON,DC 20010. GEORGE WASHINGTON UNIV,MED CTR,DEPT PEDIAT,WASHINGTON,DC 20037. GEORGE WASHINGTON UNIV,MED CTR,DEPT PATHOL,WASHINGTON,DC 20037. USA,ACAD HLTH SCI,FT SAM HOUSTON,TX 78234. RP MCLEAN, S (reprint author), CHILDRENS NATL MED CTR,DEPT MED GENET,111 MICHIGAN AVE NW,WASHINGTON,DC 20010, USA. NR 22 TC 14 Z9 14 U1 0 U2 0 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0197-3851 J9 PRENATAL DIAG JI Prenat. Diagn. PD DEC PY 1992 VL 12 IS 12 BP 985 EP 991 DI 10.1002/pd.1970121203 PG 7 WC Genetics & Heredity; Obstetrics & Gynecology SC Genetics & Heredity; Obstetrics & Gynecology GA KG181 UT WOS:A1992KG18100002 PM 1287646 ER PT J AU RUNDELL, JR KYLE, KM BROWN, GR THOMASON, JL AF RUNDELL, JR KYLE, KM BROWN, GR THOMASON, JL TI RISK-FACTORS FOR SUICIDE ATTEMPTS IN A HUMAN-IMMUNODEFICIENCY-VIRUS SCREENING-PROGRAM SO PSYCHOSOMATICS LA English DT Article ID INFECTION; AIDS C1 WILLFORD HALL MED CTR,DEPT PSYCHIAT,LACKLAND AFB,TX. HENRY M JACKSON FDN ADVANCEMENT MIL MED,SAN ANTONIO,TX. OFFUTT AFB HOSP,DEPT PSYCHIAT,OMAHA,NE. RP RUNDELL, JR (reprint author), WALTER REED ARMY MED CTR,MIL HIV BEHAV MED RES PROGRAM,WASHINGTON,DC 20307, USA. NR 7 TC 26 Z9 27 U1 0 U2 0 PU AMER PSYCHIATRIC ASSOCIATION PI WASHINGTON PA 1400 K ST NW, WASHINGTON, DC 20005 SN 0033-3182 J9 PSYCHOSOMATICS JI Psychosomatics PD WIN PY 1992 VL 33 IS 1 BP 24 EP 27 PG 4 WC Psychiatry; Psychology SC Psychiatry; Psychology GA GX673 UT WOS:A1992GX67300006 PM 1539099 ER PT J AU STENSVAAG, JT AF STENSVAAG, JT TI SEARCHING FOR CONGRUENCE - HISTORIANS AND POLICY-MAKERS IN THE UNITED-STATES-ARMY SO PUBLIC HISTORIAN LA English DT Article RP STENSVAAG, JT (reprint author), USA, TRAINING DOCTRINE COMMAND,FT MONROE,VA, USA. NR 31 TC 1 Z9 1 U1 0 U2 0 PU UNIV CALIF PRESS PI BERKELEY PA JOURNALS DEPT 2120 BERKELEY WAY, BERKELEY, CA 94720 SN 0272-3433 J9 PUBL HISTORIAN JI Public Hist. PD WIN PY 1992 VL 14 IS 1 BP 55 EP 70 PG 16 WC History SC History GA HC825 UT WOS:A1992HC82500003 ER PT J AU POPA, TA AF POPA, TA TI SOLDIERS AND SCHOLARS - THE UNITED-STATES-ARMY AND THE USES OF MILITARY HISTORY, 1865-1920 - REARDON,C SO PUBLIC HISTORIAN LA English DT Book Review RP POPA, TA (reprint author), USA, ARMY CTR MIL HIST,WASHINGTON,DC, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU UNIV CALIF PRESS PI BERKELEY PA JOURNALS DEPT 2120 BERKELEY WAY, BERKELEY, CA 94720 SN 0272-3433 J9 PUBL HISTORIAN JI Public Hist. PD WIN PY 1992 VL 14 IS 1 BP 78 EP 81 PG 4 WC History SC History GA HC825 UT WOS:A1992HC82500007 ER PT J AU SWEENEY, TW AF SWEENEY, TW TI THE ROLE OF FEDERAL MILITARY FORCES IN DOMESTIC DISORDERS, 1789-1878 - COAKLEY,RW SO PUBLIC HISTORIAN LA English DT Book Review RP SWEENEY, TW (reprint author), USA, ARMY MIL HIST INST,WASHINGTON,DC, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU UNIV CALIF PRESS PI BERKELEY PA JOURNALS DEPT 2120 BERKELEY WAY, BERKELEY, CA 94720 SN 0272-3433 J9 PUBL HISTORIAN JI Public Hist. PD WIN PY 1992 VL 14 IS 1 BP 95 EP 96 PG 2 WC History SC History GA HC825 UT WOS:A1992HC82500015 ER PT J AU MAHON, JK AF MAHON, JK TI THE STORY OF THE NONCOMMISSIONED-OFFICER-CORPS - THE BACKBONE OF THE ARMY - FISCH,AG, WRIGHT,RK SO PUBLIC HISTORIAN LA English DT Book Review C1 UNIV FLORIDA,GAINESVILLE,FL 32611. RP MAHON, JK (reprint author), USA, ARMY CTR MIL HIST,WASHINGTON,DC, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU UNIV CALIF PRESS PI BERKELEY PA JOURNALS DEPT 2120 BERKELEY WAY, BERKELEY, CA 94720 SN 0272-3433 J9 PUBL HISTORIAN JI Public Hist. PD WIN PY 1992 VL 14 IS 1 BP 103 EP 104 PG 2 WC History SC History GA HC825 UT WOS:A1992HC82500019 ER PT J AU COHEN, SH SCHREUDERGIBSON, H STAPLER, JT AF COHEN, SH SCHREUDERGIBSON, H STAPLER, JT TI STUDY OF SURFACE MODIFIED POLY(ETHYLENE) YARNS SO SCANNING MICROSCOPY LA English DT Article DE SCANNING ELECTRON MICROSCOPY; ULTRAHIGH STRENGTH POLYETHYLENE FIBER; PLASMA TREATMENT; FIBER FRICTION TESTING; POLYMER SURFACE GRAFTING ID POLYETHYLENE FIBERS; ADHESION AB Spectra(R) fibers and fabrics have been treated to enhance surface friction to determine if ballistic penetration resistance of Spectra fabric can be increased with improved interfiber friction. Scanning electron microscopy (SEM) has shown the extent of surface modification for plasma treated Spectra yarns and the uniformity of coverage for dip-coated yarns and fabrics. Of particular interest is the observation by SEM that plasma gases etch the surface of the polyethylene, producing varying effects on the fiber surface friction. While difficult to measure spectroscopically, the presence of coatings that affect fiber friction are confirmed by SEM. RP COHEN, SH (reprint author), USA,NATICK RES,CTR DEV & ENGN,SOLDIER SCI DIRECTORATE,NATICK,MA 01760, USA. NR 20 TC 2 Z9 2 U1 0 U2 1 PU SCANNING MICROSCOPY INT PI CHICAGO PA PO BOX 66507, AMF O'HARE, CHICAGO, IL 60666 SN 0891-7035 J9 SCANNING MICROSCOPY JI Scanning Microsc. PD DEC PY 1992 VL 6 IS 4 BP 997 EP 1008 PG 12 WC Microscopy SC Microscopy GA KK548 UT WOS:A1992KK54800013 ER PT J AU VONHOFF, DD MCGILL, J DAVIDSON, K FORSETH, B ELZAYAT, AAE BURRIS, H AF VONHOFF, DD MCGILL, J DAVIDSON, K FORSETH, B ELZAYAT, AAE BURRIS, H TI PRECLINICAL LEADS FOR INNOVATIVE USES FOR ETOPOSIDE SO SEMINARS IN ONCOLOGY LA English DT Article ID HOMOGENEOUSLY STAINING REGIONS; DOUBLE MINUTE CHROMOSOMES; DIHYDROFOLATE-REDUCTASE GENES; METHOTREXATE-RESISTANT CELLS; MULTIDRUG RESISTANCE; P-GLYCOPROTEIN; OVARIAN-CANCER; PROTO-ONCOGENE; DNA-MOLECULES; CIRCULAR DNA C1 BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234. RP VONHOFF, DD (reprint author), UNIV TEXAS,HLTH SCI CTR,CANC THERAPY & RES FDN S TEXAS,DEPT MED,DIV MED ONCOL,SAN ANTONIO,TX 78284, USA. FU NCI NIH HHS [UO1 CA 48405] NR 40 TC 5 Z9 5 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0093-7754 J9 SEMIN ONCOL JI Semin. Oncol. PD DEC PY 1992 VL 19 IS 6 SU 13 BP 10 EP 13 PG 4 WC Oncology SC Oncology GA KL233 UT WOS:A1992KL23300003 PM 1492222 ER PT J AU WEISS, RB AF WEISS, RB TI INTRODUCTION - NEW ANTITUMOR DRUGS IN DEVELOPMENT SO SEMINARS IN ONCOLOGY LA English DT Editorial Material C1 UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. RP WEISS, RB (reprint author), WALTER REED ARMY MED CTR,MED ONCOL SECT,WASHINGTON,DC 20307, USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0093-7754 J9 SEMIN ONCOL JI Semin. Oncol. PD DEC PY 1992 VL 19 IS 6 BP 611 EP 612 PG 2 WC Oncology SC Oncology GA KC785 UT WOS:A1992KC78500001 ER PT J AU BURRIS, HA ROTHENBERG, ML KUHN, JG VONHOFF, DD AF BURRIS, HA ROTHENBERG, ML KUHN, JG VONHOFF, DD TI CLINICAL-TRIALS WITH THE TOPOISOMERASE-I INHIBITORS SO SEMINARS IN ONCOLOGY LA English DT Article ID CAMPTOTHECIN; CPT-11; NSC-100880; TUMORS; CANCER C1 UNIV TEXAS,HLTH SCI CTR,DEPT MED,DIV ONCOL,SAN ANTONIO,TX 78284. BROOKE ARMY MED CTR,DEPT MED,DIV ONCOL,FT SAM HOUSTON,TX 78234. UNIV TEXAS,HLTH SCI CTR,DEPT MED,SCH PHARM,SAN ANTONIO,TX 78284. RP VONHOFF, DD (reprint author), UNIV TEXAS,HLTH SCI CTR,DEPT MED,DIV ONCOL,SAN ANTONIO,TX 78284, USA. NR 44 TC 71 Z9 72 U1 0 U2 1 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0093-7754 J9 SEMIN ONCOL JI Semin. Oncol. PD DEC PY 1992 VL 19 IS 6 BP 663 EP 669 PG 7 WC Oncology SC Oncology GA KC785 UT WOS:A1992KC78500006 PM 1334279 ER PT J AU WEISS, RB AF WEISS, RB TI THE ANTHRACYCLINES - WILL WE EVER FIND A BETTER DOXORUBICIN SO SEMINARS IN ONCOLOGY LA English DT Review ID ADVANCED BREAST-CANCER; NON-HODGKINS-LYMPHOMA; PHASE-II; ANTITUMOR-ACTIVITY; IDARUBICIN 4-DEMETHOXYDAUNORUBICIN; ADRIAMYCIN ANALOG; ORAL IDARUBICIN; SOLID TUMORS; EPIRUBICIN; CARDIOTOXICITY C1 UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. RP WEISS, RB (reprint author), WALTER REED ARMY MED CTR,DEPT MED,MED ONCOL SECT,WASHINGTON,DC 20307, USA. NR 105 TC 515 Z9 524 U1 4 U2 59 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0093-7754 J9 SEMIN ONCOL JI Semin. Oncol. PD DEC PY 1992 VL 19 IS 6 BP 670 EP 686 PG 17 WC Oncology SC Oncology GA KC785 UT WOS:A1992KC78500007 PM 1462166 ER PT J AU MAROLDO, TV BARKOVICH, AJ AF MAROLDO, TV BARKOVICH, AJ TI PEDIATRIC BRAIN-TUMORS SO SEMINARS IN ULTRASOUND CT AND MRI LA English DT Article RP MAROLDO, TV (reprint author), TRIPLER ARMY MED CTR,DEPT RADIOL,HONOLULU,HI 96859, USA. NR 0 TC 8 Z9 9 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0887-2171 J9 SEMIN ULTRASOUND CT JI Semin. Ultrasound CT MRI PD DEC PY 1992 VL 13 IS 6 BP 412 EP 448 PG 37 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA KE077 UT WOS:A1992KE07700001 PM 1489556 ER PT J AU KREUTZIGER, KL KREUTZIGER, KL AF KREUTZIGER, KL KREUTZIGER, KL TI ZYGOMATIC FRACTURES - REDUCTION WITH THE T-BAR SCREW SO SOUTHERN MEDICAL JOURNAL LA English DT Article AB The prominent zygomatic bone is one of the most commonly fractured. Fracture with displacement of the bone results in a cosmetic and functional deformity. The fractured zygomatic bone is usually dislocated in an inferomedial and posterior direction, which results in a cosmetic deformity with loss of ipsilateral malar prominence, possible depression of the zygomatic arch, asymmetry of the bony orbital circumference, and possible enophthalmos. Fracture of the zygomatic bone may result in ocular, maxillary antral, and mandibular dysfunction; diplopia, restricted extraocular muscle movement, or intraocular injuries; infection or obstruction of the maxillary antrum; and restricted mandibular function and malocclusion. Various surgical methods have been used to reduce the displaced fractured zygomatic bone. Our preferred method for reduction is the T-bar (Carroll-Girard) screw. This clinical study reviews 30 cases of zygomatic complex fractures, outlines the surgical technique used, illustrates the proper use of the T-bar screw with anatomic schematics and clinical cases, and presents illustrative case summaries. C1 USAMEDDAC,FT SILL,OK. REYNOLDS ARMY COMMUNITY HOSP,FT SILL,OK. RP KREUTZIGER, KL (reprint author), ALTON OCHSNER MED FDN & OCHSNER CLIN,DEPT OTORHINOLARYNGOL,1514 JEFFERSON HIGHWAY,NEW ORLEANS,LA 70121, USA. RI Kreutziger, Keith/A-5855-2011 NR 15 TC 9 Z9 10 U1 0 U2 0 PU SOUTHERN MEDICAL ASSN PI BIRMINGHAM PA 35 LAKESHORE DR PO BOX 190088, BIRMINGHAM, AL 35219 SN 0038-4348 J9 SOUTHERN MED J JI South.Med.J. PD DEC PY 1992 VL 85 IS 12 BP 1193 EP 1202 DI 10.1097/00007611-199212000-00011 PG 10 WC Medicine, General & Internal SC General & Internal Medicine GA KD412 UT WOS:A1992KD41200011 PM 1470963 ER PT J AU MORRIS, JT MCALLISTER, CK MOSS, J AF MORRIS, JT MCALLISTER, CK MOSS, J TI ACTINOMYCOSIS OF THE TONGUE SO SOUTHERN MEDICAL JOURNAL LA English DT Letter RP MORRIS, JT (reprint author), BROOKE ARMY MED CTR,INFECT DIS SERV,FT SAM HOUSTON,TX 78234, USA. NR 5 TC 1 Z9 1 U1 0 U2 0 PU SOUTHERN MEDICAL ASSN PI BIRMINGHAM PA 35 LAKESHORE DR PO BOX 190088, BIRMINGHAM, AL 35219 SN 0038-4348 J9 SOUTHERN MED J JI South.Med.J. PD DEC PY 1992 VL 85 IS 12 BP 1267 EP 1268 DI 10.1097/00007611-199212000-00035 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA KD412 UT WOS:A1992KD41200035 PM 1470984 ER PT J AU WOLFE, AD BLICK, DW MURPHY, MR MILLER, SA GENTRY, MK HARTGRAVES, SL DOCTOR, BP AF WOLFE, AD BLICK, DW MURPHY, MR MILLER, SA GENTRY, MK HARTGRAVES, SL DOCTOR, BP TI USE OF CHOLINESTERASES AS PRETREATMENT DRUGS FOR THE PROTECTION OF RHESUS-MONKEYS AGAINST SOMAN TOXICITY SO TOXICOLOGY AND APPLIED PHARMACOLOGY LA English DT Article ID ACETYLCHOLINESTERASE PROPHYLAXIS; NERVE AGENTS; MICE; PRIMATES; PYRIDOSTIGMINE; PURIFICATION; THERAPY C1 USAF,ARMSTRONG LAB,SYST RES LABS,BROOKS AFB,TX 78235. RP WOLFE, AD (reprint author), WALTER REED ARMY INST RES,DIV BIOCHEM,WASHINGTON,DC 20307, USA. NR 26 TC 55 Z9 55 U1 0 U2 1 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0041-008X J9 TOXICOL APPL PHARM JI Toxicol. Appl. Pharmacol. PD DEC PY 1992 VL 117 IS 2 BP 189 EP 193 DI 10.1016/0041-008X(92)90236-L PG 5 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA KC568 UT WOS:A1992KC56800007 PM 1471150 ER PT J AU BOYKIN, WH BRIGHT, KE ZEIDMAN, EJ THOMPSON, IM AF BOYKIN, WH BRIGHT, KE ZEIDMAN, EJ THOMPSON, IM TI RENAL TUMORS IN YOUNG-ADULTS SO UROLOGY LA English DT Article ID CELL-CARCINOMA; ADENOCARCINOMA AB Primary renal malignancies are relatively rare in young adults. Eighteen patients between the ages of twenty and forty years underwent nephrectomy for renal tumors at our institution between 1947 and 1989. Data were reviewed in this group regarding method of presentation, duration of symptoms, tumor histology, pathologic stage, and survival. Tumor histology parallels that of older patients, the majority being adenocarcinoma (78 %). The duration of symptoms prior to seeking medical attention was long, averaging eighty-four weeks. The overall survival rate, excluding nontumor deaths, was 50 percent. No patient with nodal or distant metastases survived, regardless of histology. RP BOYKIN, WH (reprint author), BROOKE ARMY MED CTR,DEPT SURG,SERV UROL,FT SAM HOUSTON,TX 78234, USA. NR 9 TC 13 Z9 14 U1 0 U2 0 PU CAHNERS PUBL CO PI NEW YORK PA 249 WEST 17 STREET, NEW YORK, NY 10011 SN 0090-4295 J9 UROLOGY JI UROLOGY PD DEC PY 1992 VL 40 IS 6 BP 503 EP 505 DI 10.1016/0090-4295(92)90402-I PG 3 WC Urology & Nephrology SC Urology & Nephrology GA KX685 UT WOS:A1992KX68500003 PM 1466101 ER PT J AU HASE, T SUMMERS, PL RAY, P ASAFOADJEI, E AF HASE, T SUMMERS, PL RAY, P ASAFOADJEI, E TI CYTOPATHOLOGY OF PC12 CELLS INFECTED WITH JAPANESE ENCEPHALITIS-VIRUS SO VIRCHOWS ARCHIV B-CELL PATHOLOGY INCLUDING MOLECULAR PATHOLOGY LA English DT Article DE GOLGI APPARATUS; JAPANESE ENCEPHALITIS VIRUS; PC12 CELL; ROUGH ENDOPLASMIC RETICULUM; VIRAL INFECTION ID SIGNAL RECOGNITION PARTICLE; CULTURED MOSQUITO CELLS; NERVE GROWTH-FACTOR; PROTEIN TRANSLOCATION; ENDOPLASMIC-RETICULUM; GOLGI-APPARATUS; PHEOCHROMOCYTOMA CELLS; MICROSOMAL-MEMBRANES; SECRETORY PROTEIN; ANIMAL-CELLS AB Infection of a clonal rat pheochromocytoma cell line, PC12, with Japanese encephalitis (JE) virus produced successively higher titers of virus in the culture fluid during the 72-h experimental period. In electron microscopical observation, JE virus entered PC12 cells by direct penetration through the plasma membrane at 2 min postinoculation (p.i.) and caused marked cellular hypertrophy and extensive proliferation of the cellular secretory system including rough endoplasmic reticulum (RER) and Golgi complexes starting 24 h p.i. The proliferating RER of the virally infected cells contained progeny virions and characteristic endoplasmic reticulum vesicles in its cisternae, and the proliferating Golgi complexes contained virions in their saccules. These findings indicated that the proliferation of the cellular secretory system occurred in association with viral replication and maturation in the system. Seventy-two hours p.i., the cellular secretory system of infected PC12 cells showed degenerative changes with vesiculation, disorganization, and dispersion of the Golgi complexes and fragmentation, focal cystic dilation, and dissolution of the RER in the same manner as those seen in the secretory system of JE-virus-infected neurons in the mouse brain. Thus, JE-virus-infected PC12 cells seem to be a suitable neurogenic cell line for the study of the pathogenic mechanism of JE virus. At the same time, the virally infected cells seem to offer an interesting cell model for the study of the morphogenesis of the cellular secretory system. C1 WALTER REED ARMY INST RES,DEPT BIOL RES,WASHINGTON,DC 20307. WALTER REED ARMY INST RES,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307. RP HASE, T (reprint author), WALTER REED ARMY INST RES,DEPT ULTRASTRUCT PATHOL,WASHINGTON,DC 20307, USA. NR 34 TC 10 Z9 10 U1 0 U2 0 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0340-6075 J9 VIRCHOWS ARCH B JI Virchows Arch. B-Cell Molec. Pathol. PD DEC PY 1992 VL 63 IS 1 BP 25 EP 36 PG 12 WC Pathology SC Pathology GA KC421 UT WOS:A1992KC42100004 PM 1362019 ER PT J AU UNGAR, SG LAYMAN, R CAMPBELL, JE WALSH, J MCKIM, HJ AF UNGAR, SG LAYMAN, R CAMPBELL, JE WALSH, J MCKIM, HJ TI DETERMINATION OF SOIL-MOISTURE DISTRIBUTION FROM IMPEDANCE AND GRAVIMETRIC MEASUREMENTS SO JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES LA English DT Article AB Daily measurements of the soil dielectric properties at 5 and 10 cm were obtained at five locations throughout the First ISLSCP Field Experiment (FIFE) test site during the 1987 intensive field campaigns (IFCs). An automated vector voltmeter was used to monitor the complex electrical impedance, at 10 MHz, of cylindrical volumes of soil delineated by specially designed soil moisture probes buried at these locations. The objective of this exercise was to test the hypothesis that the soil impedance is sensitive to the moisture content of the soil and that the imaginary part (that is, capacitive reactance) can be used to calculate the volumetric water content of the soil. These measurements were compared with gravimetric samples collected at these locations by the FIFE staff science team. In addition to the five fixed locations, measurements were made throughout each of the IFCs along three transects underlying airborne push broom microwave radiometer (PBMR) flights and compared with the results of gravimetric sampling done in support of these flights. Examination of the data reveals that the impedance probe is a more consistent source of time series information than traditional measurements and is potentially more closely linked to the physical parameters which are both remotely sensible and required for surface energy/mass exchange determination. C1 DARTMOUTH COLL,HANOVER,NH 03755. USA,COLD REG RES & ENGN LAB,HANOVER,NH 03755. RP UNGAR, SG (reprint author), NASA,GODDARD SPACE FLIGHT CTR,GREENBELT,MD 20771, USA. NR 7 TC 14 Z9 14 U1 0 U2 4 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 SN 0148-0227 J9 J GEOPHYS RES-ATMOS JI J. Geophys. Res.-Atmos. PD NOV 30 PY 1992 VL 97 IS D17 BP 18969 EP 18977 PG 9 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA KC520 UT WOS:A1992KC52000054 ER PT J AU MAMMONE, RJ WADE, WL BINDER, M AF MAMMONE, RJ WADE, WL BINDER, M TI INCREASED BREAKDOWN STRENGTHS OF POLYPROPYLENE FILMS MELT-EXTRUDED FROM PLASMA-TREATED RESIN SO JOURNAL OF APPLIED POLYMER SCIENCE LA English DT Article ID CARBON-DIOXIDE AB Thin (11-36 mum) films formed by melt extruding polypropylene resin after the resin had been briefly exposed to low pressure, low temperature, 96% CF4/4% O2 gas plasma, exhibited approximately a 20% increase in dielectric breakdown strength. RP MAMMONE, RJ (reprint author), USA,ELECTR TECHNOL & DEV LAB,LAB COMMAND,DIV POWER SOURCES,SLCET PR,FT MONMOUTH,NJ 07703, USA. NR 7 TC 3 Z9 3 U1 0 U2 0 PU JOHN WILEY & SONS INC PI NEW YORK PA 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0021-8995 J9 J APPL POLYM SCI JI J. Appl. Polym. Sci. PD NOV 25 PY 1992 VL 46 IS 9 BP 1531 EP 1534 DI 10.1002/app.1992.070460902 PG 4 WC Polymer Science SC Polymer Science GA JV607 UT WOS:A1992JV60700002 ER PT J AU MAMMONE, RJ BINDER, M AF MAMMONE, RJ BINDER, M TI EFFECTS OF CF4/O-2 GAS PLASMA POWER EXPOSURE TIME ON DIELECTRIC-PROPERTIES AND BREAKDOWN VOLTAGES OF PVDF FILMS SO JOURNAL OF APPLIED POLYMER SCIENCE LA English DT Article AB Dielectric properties and electrical breakdown strengths were measured on 12-mum-thick poly(vinylidene fluoride) films before and after exposure to various power levels and exposure times in a 96% CF4/4% O2 gas plasma. Significant changes in dielectric constant, dielectric losses, and breakdown voltages were observed. Breakdown voltages for PVDF films as a function of exposure time and plasma power appear to go through a maximum. RP MAMMONE, RJ (reprint author), USA,ELECTR TECHNOL & DEVICES LAB,LAB COMMAND,DIV POWER SOURCES,FT MONMOUTH,NJ 07703, USA. NR 5 TC 1 Z9 1 U1 0 U2 2 PU JOHN WILEY & SONS INC PI NEW YORK PA 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0021-8995 J9 J APPL POLYM SCI JI J. Appl. Polym. Sci. PD NOV 25 PY 1992 VL 46 IS 9 BP 1535 EP 1538 DI 10.1002/app.1992.070460903 PG 4 WC Polymer Science SC Polymer Science GA JV607 UT WOS:A1992JV60700003 ER PT J AU CROSS, AS OPAL, SM AF CROSS, AS OPAL, SM TI GROUP-B STREPTOCOCCAL SEPSIS SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Letter ID DISEASE C1 MEM HOSP,PAWTUCKET,RI 02860. RP CROSS, AS (reprint author), WALTER REED ARMY INST RES,WASHINGTON,DC 20307, USA. NR 3 TC 0 Z9 0 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD NOV 18 PY 1992 VL 268 IS 19 BP 2651 EP 2651 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA JX680 UT WOS:A1992JX68000020 PM 1433683 ER PT J AU BERKY, ZT LUCIANO, WJ JAMES, WD AF BERKY, ZT LUCIANO, WJ JAMES, WD TI LATEX GLOVE ALLERGY - A SURVEY OF THE UNITED-STATES-ARMY-DENTAL-CORPS SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Note ID CONTACT URTICARIA; RUBBER GLOVES; HOSPITAL PERSONNEL; ANAPHYLAXIS; DERMATITIS; HEALTH; VINYL AB Objective.-To assess the prevalence of latex glove allergy in a population of health care providers (dentists) with a high occupational exposure to latex gloves. Design.-A survey instrument was distributed to all active-duty dental officers in the US Army (n=1628). The survey was designed to identify those individuals who had symptoms of allergy to latex gloves. Setting.-US Army dental facilities worldwide. Results.-The response rate to the survey was 64% (n=1043). There were 143 (13.7%) responses indicating latex glove allergy. If nonrespondents were assumed to be allergy-free, the prevalence rate would be 8.8%. Conclusion.-Latex allergy, as ascertained by self-report in this survey, appears to have a substantial prevalence in this health care provider population. C1 USA,DENT CLIN,FT RICHIE,MD. WALTER REED ARMY MED CTR,DERMATOL SERV,WASHINGTON,DC 20307. RP BERKY, ZT (reprint author), CRAVEN DENT CLIN,FT KNOX,KY 40121, USA. NR 39 TC 76 Z9 76 U1 0 U2 1 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD NOV 18 PY 1992 VL 268 IS 19 BP 2695 EP 2697 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA JX680 UT WOS:A1992JX68000032 PM 1433688 ER PT J AU WU, JC WYBOURNE, MN BERVEN, C GOODNICK, SM SMITH, DD AF WU, JC WYBOURNE, MN BERVEN, C GOODNICK, SM SMITH, DD TI NEGATIVE DIFFERENTIAL CONDUCTANCE OBSERVED IN A LATERAL DOUBLE CONSTRICTION DEVICE SO APPLIED PHYSICS LETTERS LA English DT Article ID HOT-ELECTRON DIODES; BALLISTIC TRANSPORT; GAS AB Lateral double point contact devices were fabricated using a split-gate high electron mobility transistor. The low-temperature source-drain characteristics show pronounced S-shaped negative differential conductance that can be independently controlled by an applied gate bias. The mechanism for the observed switching behavior is believed to be similar to that proposed for heterostructure hot electron diodes. C1 OREGON STATE UNIV,DEPT ELECT & COMP ENGN,CORVALLIS,OR 97331. USA,ETDL,SLCET,ED,FT MONMOUTH,NJ 07703. RP WU, JC (reprint author), UNIV OREGON,DEPT PHYS,EUGENE,OR 97403, USA. NR 11 TC 17 Z9 17 U1 1 U2 1 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD NOV 16 PY 1992 VL 61 IS 20 BP 2425 EP 2427 DI 10.1063/1.108186 PG 3 WC Physics, Applied SC Physics GA JY227 UT WOS:A1992JY22700017 ER PT J AU KARLE, JM KARLE, IL AF KARLE, JM KARLE, IL TI STRUCTURE OF 9-EPIQUININE HYDROCHLORIDE DIHYDRATE VERSUS ANTIMALARIAL ACTIVITY SO ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS LA English DT Article ID MALARIA; MONOHYDRATE; MEFLOQUINE; QUININE AB 9-Epiquinine hydrochloride dihydrate [(9S)-6'-methoxycinchonan-9-ol hydrochloride dihydrate], C20H25N2O2+.Cl-.2H2O, M(r) = 396.9, orthorhombic, P2(1)2(1)2(1), a = 8.059 (2), b = 11.537 (3), c = 22.311 (6) angstrom, V = 2074.1 (9) angstrom3, Z = 4, D(x) = 1.271 g cm-3, Cu Kalpha, lambda = 1.54178 angstrom, mu = 18.58 cm-1, F(000) = 848, room temperature, final R = 6.56% for 1344 reflections with \F(o)\ > 3sigma(F). Epiquinine crystallized as a hydrated tertiary amine 9-hydrochloride salt. The intramolecular N(1)+...O distance is 2.816 angstrom. All H atoms attached to O or N atoms form intermolecular hydrogen bonds. The Cl ion is involved in four hydrogen bonds including one with the hydroxyl group of 9-epiquinine. The N(l)+-H moiety hydrogen bonds to a water molecule. The O(12)-C(9)...N(1)+-H(1) torsion angle was equal to - 0.2 (3.8)-degrees in comparison to 97.0-degrees for quinidine sulfate [Karle & Karle (1981). Proc. Natl Acad. Sci. USA, 78, 5938-5941]. Two theories have been proposed in the literature to explain the low antimalarial activity of 9-epiquinine. The crystal structure of 9-epiquinine hydrochloride is not consistent with the hypothesis that 9-epiquinine prefers to form intramolecular rather than intermolecular hydrogen bonds, but is consistent with the hypothesis that N(1) and the hydroxyl group of 9-epiquinine are in an orientation which is unfavorable towards exerting antimalarial activity. C1 USN,RES LAB,STRUCT MATTER LAB,WASHINGTON,DC 20375. RP KARLE, JM (reprint author), WALTER REED ARMY INST RES,DEPT PHARMACOL,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307, USA. NR 17 TC 9 Z9 9 U1 1 U2 2 PU MUNKSGAARD INT PUBL LTD PI COPENHAGEN PA 35 NORRE SOGADE, PO BOX 2148, DK-1016 COPENHAGEN, DENMARK SN 0108-2701 J9 ACTA CRYSTALLOGR C JI Acta Crystallogr. Sect. C-Cryst. Struct. Commun. PD NOV 15 PY 1992 VL 48 BP 1975 EP 1980 DI 10.1107/S0108270192002373 PN 11 PG 6 WC Chemistry, Multidisciplinary; Crystallography SC Chemistry; Crystallography GA KA452 UT WOS:A1992KA45200021 PM 1457075 ER PT J AU MCCANN, UD RICAURTE, GA AF MCCANN, UD RICAURTE, GA TI MDMA (ECSTASY) AND PANIC DISORDER - INDUCTION BY A SINGLE DOSE SO BIOLOGICAL PSYCHIATRY LA English DT Article ID PSYCHOSIS C1 WALTER REED ARMY INST RES,DEPT BEHAV BIOL,WASHINGTON,DC 20307. JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROL,BALTIMORE,MD 21205. RP MCCANN, UD (reprint author), NIMH,ANXIETY & AFFECT DISORDERS SECT,BLDG 10,ROOM 3S-239,BETHESDA,MD 20892, USA. FU NIDA NIH HHS [DA 05938] NR 14 TC 53 Z9 53 U1 0 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0006-3223 J9 BIOL PSYCHIAT JI Biol. Psychiatry PD NOV 15 PY 1992 VL 32 IS 10 BP 950 EP 953 DI 10.1016/0006-3223(92)90185-3 PG 4 WC Neurosciences; Psychiatry SC Neurosciences & Neurology; Psychiatry GA KC871 UT WOS:A1992KC87100012 PM 1361366 ER PT J AU KORNBLITH, AB ANDERSON, J CELLA, DF TROSS, S ZUCKERMAN, E CHERIN, E HENDERSON, ES CANELLOS, GP KOSTY, MP COOPER, R WEISS, RB GOTTLIEB, A HOLLAND, JC AF KORNBLITH, AB ANDERSON, J CELLA, DF TROSS, S ZUCKERMAN, E CHERIN, E HENDERSON, ES CANELLOS, GP KOSTY, MP COOPER, R WEISS, RB GOTTLIEB, A HOLLAND, JC TI COMPARISON OF PSYCHOSOCIAL ADAPTATION AND SEXUAL FUNCTION OF SURVIVORS OF ADVANCED HODGKIN DISEASE TREATED BY MOPP, ABVD, OR MOPP ALTERNATING WITH ABVD SO CANCER LA English DT Article DE PSYCHOSOCIAL ADAPTATION; PSYCHOSEXUAL; HODGKIN DISEASE; CANCER SURVIVORS; MOPP; ABVD ID ILLNESS SCALE PAIS; CANCER SURVIVORS; TESTIS CANCER; TELEPHONE; CHEMOTHERAPY; INTERVIEW; ADJUSTMENT; CHILDHOOD; ANXIETY AB Background. Survivors of advanced Hodgkin disease, who were assigned randomly to treatment by mechlorethamine, vincristine, procarbazine, and prednisone (MOPP); doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD); or MOPP alternating with ABVD in a clinical trial of the Cancer and Leukemia Group B (protocol 8251), were compared in terms of their psychosocial adaptation and psychosexual function an average of 2.2 years after completion of treatment (range, 1-5 years). The study was undertaken to determine if there were differences among treatments in these functional areas as a consequence of differential long-term gonadal damage in the three regimens. Methods. Ninety-three disease-free survivors of advanced Hodgkin disease (56 men and 37 women) were studied (a minimum of 1 year after completion of treatment) by an interview conducted over the telephone. Standardized measures were used to assess their psychologic, sexual, family, and vocational functioning, including the following tests: the Psychosocial Adjustment to Illness Scale-Self Report, the Brief Symptom Inventory, the Profile of Mood States, and the Impact of Event Scale. Results. Contrary to expectation, no statistically significant differences in survivors' psychosocial adaptation or psychosexual function were found by treatment arm. Infertility (based on survivors' reports of medical test results and perceptions) and lower income 1 year before the diagnosis of cancer were significant predictors of poorer adjustment. Most survivors reported a range of problems that they attributed to having had cancer: 35%, proven or perceived infertility; 24%, sexual problems; 31%, health and life insurance problems; 26%, a negative socioeconomic effect; and 51%, conditioned nausea, associated with visual or olfactory reminders of chemotherapy. Conclusions. No significant long-term advantage in psychosocial adaptation or psychosexual function was found for survivors of Hodgkin disease treated by the less gonadally toxic ABVD regimen 1 to 5 years after completion of treatment. C1 UNIV NEBRASKA,MED CTR,OMAHA,NE 68105. RUSH PRESBYTERIAN ST LUKES MED CTR,CHICAGO,IL 60612. UNIV MED & DENT NEW JERSEY,NEWARK,NJ 07103. US FDA,ROCKVILLE,MD. HARVARD UNIV,SCH MED,DANA FARBER CANC INST,BOSTON,MA 02115. SCRIPPS CLIN & RES FDN,SAN DIEGO,CA. BOWMAN GRAY MED CTR,WINSTON SALEM,NC. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. SUNY SYRACUSE,HLTH SCI CTR,SYRACUSE,NY. RP KORNBLITH, AB (reprint author), MEM SLOAN KETTERING CANC CTR,PSYCHIAT SERV,1275 YORK AVE,NEW YORK,NY 10021, USA. FU NCI NIH HHS [CA 03927, CA 32291, CA31946] NR 50 TC 49 Z9 49 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0008-543X J9 CANCER JI Cancer PD NOV 15 PY 1992 VL 70 IS 10 BP 2508 EP 2516 DI 10.1002/1097-0142(19921115)70:10<2508::AID-CNCR2820701020>3.0.CO;2-V PG 9 WC Oncology SC Oncology GA JX894 UT WOS:A1992JX89400019 PM 1384949 ER PT J AU OSTER, CN SANFORD, JP AF OSTER, CN SANFORD, JP TI FEBRILE ILLNESS IN A DESERT-STORM VETERAN SO HOSPITAL PRACTICE LA English DT Article RP OSTER, CN (reprint author), USA,MED CORPS,WASHINGTON,DC 20310, USA. NR 0 TC 3 Z9 3 U1 0 U2 0 PU MCGRAW HILL HEALTHCARE PUBLICATIONS PI MINNEAPOLIS PA 4530 WEST 77TH ST, MINNEAPOLIS, MN 55435-5000 SN 8750-2836 J9 HOSP PRACT JI Hosp. Pract. PD NOV 15 PY 1992 VL 27 IS 11 BP 145 EP & PG 0 WC Medicine, General & Internal SC General & Internal Medicine GA JY922 UT WOS:A1992JY92200013 PM 1331138 ER PT J AU MITTAL, S TEZDUYAR, TE AF MITTAL, S TEZDUYAR, TE TI A FINITE-ELEMENT STUDY OF INCOMPRESSIBLE FLOWS PAST OSCILLATING-CYLINDERS AND AEROFOILS SO INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN FLUIDS LA English DT Article; Proceedings Paper CT INTERNATIONAL CONF ON COMPUTING IN CIVIL AND BUILDING ENGINEERING CY JUL 31-AUG 01, 1991 CL TOKYO, JAPAN DE SPACE TIME; FINITE; ELEMENTS; INCOMPRESSIBLE; FLOWS; GALERKIN LEAST-SQUARES; DEFORMING; SPATIAL DOMAIN; OSCILLATING CYLINDER; PITCHING AEROFOIL; CLUSTERED ELEMENT-BY-ELEMENT; GMRES; VORTEX SHEDDING; VORTEX-INDUCED OSCILLATIONS; LOCK-IN; HYSTERESIS ID VORTEX; SYSTEMS AB We present our numerical results for certain unsteady flows past oscillating cylinders and aerofoils. The computations are based on the stabilized space time finite element formulation. The implicit equation systems resulting from the space-time finite element discretizations are solved using iterative solution techniques. One of the problems studied is flow past a cylinder which is forced to oscillate in the horizontal direction. In this case we observe a change from an unsymmetric mode of vortex shedding to a symmetric one. An extensive study was carried out for the case in which a cylinder is mounted on lightly damped springs and allowed to oscillate in the vertical direction. In this case the motion of the cylinder needs to be determined as part of the solution, and under certain conditions this motion changes the vortex-shedding pattern of the flow field significantly. This non-linear fluid structure interaction exhibits certain interesting behaviour such as 'lock-in' and 'hysteresis', which are in good agreement with the laboratory experiments carried out by other researchers in the past. Preliminary results for flow past a pitching aerofoil are also presented. C1 UNIV MINNESOTA,MINNESOTA SUPERCOMP INST,MINNEAPOLIS,MN 55415. RP MITTAL, S (reprint author), UNIV MINNESOTA,USA,HIGH PERFORMANCE COMP RES CTR,DEPT AEROSP ENGN & MECH,1200 WASHINGTON AVE S,MINNEAPOLIS,MN 55415, USA. RI Tezduyar, Tayfun/F-6134-2012 OI Tezduyar, Tayfun/0000-0001-8707-3162 NR 23 TC 101 Z9 102 U1 0 U2 9 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0271-2091 J9 INT J NUMER METH FL JI Int. J. Numer. Methods Fluids PD NOV 15 PY 1992 VL 15 IS 9 BP 1073 EP 1118 DI 10.1002/fld.1650150911 PG 46 WC Computer Science, Interdisciplinary Applications; Mathematics, Interdisciplinary Applications; Mechanics; Physics, Fluids & Plasmas SC Computer Science; Mathematics; Mechanics; Physics GA JX943 UT WOS:A1992JX94300010 ER PT J AU SCHMIEDEL, T MCCOMBE, BD PETROU, A DUTTA, M NEWMAN, PG AF SCHMIEDEL, T MCCOMBE, BD PETROU, A DUTTA, M NEWMAN, PG TI SUBBAND TUNING IN SEMICONDUCTOR QUANTUM-WELLS USING NARROW BARRIERS SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID SUPERLATTICE AB A method for controlling the intersubband spacing in GaAs/AlGaAs quantum wells by incorporating a thin AlAs barrier at the well center has been investigated using reflectance and photoluminescence spectroscopy. Two structures with 5.7 and 11.3 angstrom AlAs barriers were studied. The predicted exciton sequence for the first sample (5.7 angstrom barrier) is E1h < E1l < E2h < E2l, whereas for the second structure (11.3 angstrom barrier), the predicted sequence is E1h < E2h < E1l < E2l. This work verifies that the sequence reversal, predicted for the 11.3 angstrom sample, occurs by performing polarization excitation luminescence measurements on these samples. C1 SUNY BUFFALO,CTR ELECTR & ELECTROOPT MAT,BUFFALO,NY 14260. USA,ELECTR TECHNOL & DEVICES LAB,FT MONMOUTH,NJ 07703. RP SCHMIEDEL, T (reprint author), SUNY BUFFALO,DEPT PHYS & ASTRON,BUFFALO,NY 14260, USA. NR 7 TC 5 Z9 6 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD NOV 15 PY 1992 VL 72 IS 10 BP 4753 EP 4756 DI 10.1063/1.352085 PG 4 WC Physics, Applied SC Physics GA JX766 UT WOS:A1992JX76600038 ER PT J AU LEE, HS COLE, MW LAREAU, RT SCHAUER, SN FOX, DC ECKART, DW MOERKIRK, RP CHANG, WH JONES, KA ELAGOZ, S VAVRA, W CLARKE, R AF LEE, HS COLE, MW LAREAU, RT SCHAUER, SN FOX, DC ECKART, DW MOERKIRK, RP CHANG, WH JONES, KA ELAGOZ, S VAVRA, W CLARKE, R TI THE MICROSTRUCTURE AND ELECTRICAL-PROPERTIES OF NONALLOYED EPITAXIAL AU-GE OHMIC CONTACTS TO N-GAAS SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID MOLECULAR-BEAM EPITAXY; REDISTRIBUTION AB The microstructure and electrical properties of nonalloyed epitaxial Au-Ge contacts were studied. Ohmic behavior was obtained after a 3 h anneal at 320-degrees-C with the lowest average contact resistance and specific contact resistivity found to be approximately 0.28 OMEGA mm and approximately 7 X 10(-6) OMEGA cm2, respectively. Localized reactions in the form of islands were observed across the surface of the contact after annealing and were composed of Au, Ge, and As, as determined by secondary ion mass spectroscopy (SIMS) imaging and Auger depth profiling. Back side SIMS profiles indicate deep Ge and Au diffusion into the GaAs substrate in the island regions. Ohmic contact behavior was found to depend upon both the kinetics of the reactions (localized reactions and island growth) and the thermodynamics (substantial diffusion of both Au and Ge) of the system. A model describing the coupled Au and Ge in-diffusion with respect to the GaAs substrate is presented. C1 UNIV MICHIGAN,HARRISON M RANDALL LAB PHYS,ANN ARBOR,MI 48109. RP LEE, HS (reprint author), USA,ELECTR TECHNOL & DEVICES LAB,FT MONMOUTH,NJ 07703, USA. NR 30 TC 9 Z9 9 U1 0 U2 3 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD NOV 15 PY 1992 VL 72 IS 10 BP 4773 EP 4780 DI 10.1063/1.352089 PG 8 WC Physics, Applied SC Physics GA JX766 UT WOS:A1992JX76600042 ER PT J AU NATH, J OHNO, Y GALLIN, JI WRIGHT, DG AF NATH, J OHNO, Y GALLIN, JI WRIGHT, DG TI A NOVEL POSTTRANSLATIONAL INCORPORATION OF TYROSINE INTO MULTIPLE PROTEINS IN ACTIVATED HUMAN NEUTROPHILS - CORRELATION WITH PHAGOCYTOSIS AND ACTIVATION OF THE NADPH OXIDASE-MEDIATED RESPIRATORY BURST SO JOURNAL OF IMMUNOLOGY LA English DT Article ID HUMAN POLYMORPHONUCLEAR LEUKOCYTES; PHORBOL-MYRISTATE ACETATE; CHRONIC GRANULOMATOUS-DISEASE; TUBULIN TYROSINOLATION; CYTOCHROME-B; SUPEROXIDE RELEASE; ALPHA-TUBULIN; CYTOPLASTS; FERTILIZATION; CELLS AB Activation of human neutrophils by PMA causes a post-translational incorporation of C-14-labeled tyrosine into multiple neutrophil (PMN) proteins, that is distinctly different from the enzymatic tyrosinolation of tubulin in FMLP-stimulated PMN. Post-translational incorporation of other radiolabeled amino acids, including the structurally similar amino acid phenylalanine, does not occur under identical conditions of neutrophil activation, suggesting an involvement of the phenolic hydroxyl group of tyrosine in the PMA-mediated reaction. Similar to the stimulation of PMN tubulin tyrosinolation by FMLP, the PMA-induced incorporation of tyrosine into multiple PMN proteins is closely associated with activation of the NADPH oxidase-mediated respiratory burst in stimulated PMN and can be inhibited by a variety of reducing agents, inhibitors of peroxidase-mediated reactions, and intracellular scavengers of oxygen radicals. Moreover, the PMA-induced post-translational incorporation of tyrosine does not occur in PMN from patients with chronic granulomatous disease and is significantly reduced (50%) in PMN of an individual with myeloperoxidase deficiency. A similar stimulus-induced incorporation of tyrosine into multiple PMN proteins is also observed in PMN exposed to various phagocytic stimuli, and the incorporated radioactivity in cells undergoing phagocytosis is substantially enriched (40- to 50-fold) in isolated PMN phagolysosomes. Consistent with this latter observation, HPLC fractionation of stimulated PMN proteins and analysis of the incorporated radioactivity reveal that the C-14 label is primarily associated with PMN membrane proteins. Furthermore, this post-translational incorporation of tyrosine, like that associated with PMA stimulation, is associated with production of oxygen radicals and the generation of protein carbonyl derivatives, which are indicative of oxidative protein modifications via mixed function oxidases. Our findings indicate that tyrosine incorporation into membrane proteins of stimulated PMN is functionally relevant to the physiologic host-defense responses of human neutrophils undergoing phagocytosis. C1 NIAID,HOST DEF LAB,BETHESDA,MD 20892. RP NATH, J (reprint author), WALTER REED ARMY INST RES,DEPT HEMATOL,DIV MED,WASHINGTON,DC 20307, USA. NR 42 TC 6 Z9 6 U1 0 U2 0 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD NOV 15 PY 1992 VL 149 IS 10 BP 3360 EP 3371 PG 12 WC Immunology SC Immunology GA JX480 UT WOS:A1992JX48000032 PM 1331234 ER PT J AU BISWAS, A PINNICK, RG XIE, JG RUEKGAUER, TE ARMSTRONG, RL AF BISWAS, A PINNICK, RG XIE, JG RUEKGAUER, TE ARMSTRONG, RL TI OBSERVATIONS OF STIMULATED RAMAN-SCATTERING AND LASER-INDUCED BREAKDOWN IN MILLIMETER-SIZED DROPLETS SO OPTICS LETTERS LA English DT Article ID MORPHOLOGY-DEPENDENT RESONANCES; WAVELENGTH DEPENDENCE; LIQUID DROPLETS; EMISSION; TIME; MICRODROPLETS; SPECTROSCOPY; LEVITATION; GENERATION; ENERGY AB We report the first observations, to our knowledge, of nonlinear optical effects in large (millimeter-sized) droplets. Stimulated Raman scattering (SRS) and laser-induced breakdown (LIB) are simultaneously observed in acoustically levitated millimeter-sized glycerol droplets irradiated by either a frequency-doubled (532-nm) or a frequency-tripled (355-nm) Nd:YAG laser. The two processes, which occur above a nearly coincident irradiation threshold, are conjectured to arise from a common initiation mechanism: self-focusing. LIB generates vapor bubbles within the droplet, resulting in the quenching of SRS emission. C1 USA,RES LAB,WHITE SANDS MISSILE RANGE,NM 88002. NEW MEXICO STATE UNIV,DEPT PHYS,LAS CRUCES,NM 88003. RP BISWAS, A (reprint author), JET PROP LAB,MS 183-401,4800 OAK GROVE DR,PASADENA,CA 91109, USA. NR 26 TC 5 Z9 5 U1 1 U2 6 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0146-9592 J9 OPT LETT JI Opt. Lett. PD NOV 15 PY 1992 VL 17 IS 22 BP 1569 EP 1571 DI 10.1364/OL.17.001569 PG 3 WC Optics SC Optics GA JX226 UT WOS:A1992JX22600005 PM 19798248 ER PT J AU GLUSHKA, J CASSELS, FJ CARLSON, RW VANHALBEEK, H AF GLUSHKA, J CASSELS, FJ CARLSON, RW VANHALBEEK, H TI COMPLETE STRUCTURE OF THE ADHESION RECEPTOR POLYSACCHARIDE OF STREPTOCOCCUS-ORALIS ATCC-55229 (STREPTOCOCCUS-SANGUIS H1) SO BIOCHEMISTRY LA English DT Article ID CAPNOCYTOPHAGA-OCHRACEA ATCC-33596; ACTINOMYCES-VISCOSUS T14V; CAPSULAR POLYSACCHARIDE; CELL-INTERACTIONS; POTENTIAL ROLE; COAGGREGATION; SPECTROSCOPY; BACTERIA; NMR; SURFACE AB This report describes the determination of the complete primary structure of the adhesin receptor polysaccharide of Streptococcus oralis ATCC 55229 (previously characterized as Streptococcus sanguis H1), a Gram-positive bacteria implicated in dental plaque formation. The polysaccharide was isolated from S. oralis ATCC 55229 cells after deproteination, enzymatic hydrolysis, and ion exchange chromatography. It was shown to consist of rhamnose, galactose, glucose, glycerol, and phosphate, in molar ratios of 2:3:1:1:1. Sequence and linkage assignments of the glycosyl residues were obtained by methylation analysis followed by gas-liquid chromatography and electron-impact mass spectrometry. P-31 NMR spectroscopy revealed that phosphate was present in a diester, connecting glycerol to one of the galactosyl residues. High-performance liquid chromatography of a partial acid hydrolysate of the polysaccharide confirmed this finding by showing galactose 6-phosphate and glycerol I-phosphate. The structural determination was completed by the combination of two-dimensional homonuclear Hartmann-Hahn and NOE experiments and heteronuclear {H-1,C-13) and {H-1, P-31} multiple-quantum coherence experiments. Thus, the adhesin receptor polysaccharide of S. oralis ATCC 55229 was found to be a polymer composed of hexasaccharide repeating units that contain glycerol linked through a phosphodiester to C6 of the alpha-galactopyranosyl residue and are joined end-to-end through galactofuranosyl-beta(1-->3)-rhamnopyranosyl linkages: [GRAPHICS] This structure is novel among bacterial cell surface polysaccharides in general and specifically among those implicated in dental plaque formation. C1 UNIV GEORGIA,COMPLEX CARBOHYDRATE RES CTR,ATHENS,GA 30602. UNIV GEORGIA,DEPT BIOCHEM,ATHENS,GA 30602. WALTER REED ARMY INST RES,DEPT GASTROENTEROL,WASHINGTON,DC 20307. FU NCRR NIH HHS [P41-RR-05351] NR 38 TC 18 Z9 18 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0006-2960 J9 BIOCHEMISTRY-US JI Biochemistry PD NOV 10 PY 1992 VL 31 IS 44 BP 10741 EP 10746 DI 10.1021/bi00159a014 PG 6 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA JX837 UT WOS:A1992JX83700014 PM 1420190 ER PT J AU VELOSO, D SMITH, JI DENNY, S COSGRIFF, TM AF VELOSO, D SMITH, JI DENNY, S COSGRIFF, TM TI STRUCTURE, KINETICS, AND FUNCTION OF HUMAN AND RHESUS PLASMA PREKALLIKREINS ARE SIMILAR SO THROMBOSIS AND HAEMOSTASIS LA English DT Article ID MOLECULAR-WEIGHT KININOGEN; FACTOR-DEPENDENT FIBRINOLYSIS; ANTIBODY IMMUNOSORBENT-ASSAY; HAGEMAN-FACTOR ACTIVATION; PROTEIN-C INHIBITOR; FACTOR-XII; CONTACT ACTIVATION; ELECTROPHORETIC TRANSFER; POLYACRYLAMIDE GELS; C1BAR INACTIVATOR AB To determine if rhesus monkeys (Macaca mulatta) could serve as a model for studying the role of the contact system in the pathophysiology of human infections, we compared structural, kinetic, and functional characteristics of plasma prekallikrein and its activation products in rhesus and humans. Three prekallikrein variants (85-, 89- and 93-kDa) were revealed in rhesus plasma as compared with the two variants (85- and 88-kDa) in human plasma by immunoblotting with the monoclonal antibody MAb 13G11. The prekallikrein concentration in rhesus plasma was 1.5-fold that in human plasma as determined by computerized immunoblot analyses (CIBA) and amidolytic activity. The electrophoretic mobility of prekallikrein from plasma of both species increased after deglycosylation. Inhibition of prekallikrein activation by MAb 13G11 was 55% (rhesus plasma) and 76% (human plasma), with similar inhibition curves. Immunoblots of activated rhesus plasma showed prekallikrein, complexes of kallikrein with Cl inhibitor, alpha2-macroglobulin and approximately 60-kDa inhibitor(s) (viz. antithrombin III), and 45-kDa fragments, like those in activated human plasma. Concentrations and molecular masses of factor XII and high molecular weight kininogen were similar in rhesus and human plasma. The activated partial thromboplastin time (APTT) and prothrombin time were 20.1 +/- 1.6 and 9.7 +/- 0.3 s for rhesus and 32.0 +/- 5.6 and 12 +/- 0.5 s for human plasma. Human and rhesus APTTs were similar when prekallikrein concentrations in human and rhesus plasma became alike by adding human purified prekallikrein. We conclude that the contact systems of rhesus and humans are similar in many respects and that rhesus should be a useful model to study the role of the contact system in the pathophysiology of human infectious diseases. C1 USA,MED RES INST INFECT DIS,DIV MED,FREDERICK,MD 21701. FITZSIMONS ARMY MED CTR,DEPT MED,AURORA,CO 80045. NR 48 TC 6 Z9 6 U1 0 U2 0 PU F K SCHATTAUER VERLAG GMBH PI STUTTGART PA P O BOX 10 45 45, LENZHALDE 3, D-70040 STUTTGART, GERMANY SN 0340-6245 J9 THROMB HAEMOSTASIS JI Thromb. Haemost. PD NOV 10 PY 1992 VL 68 IS 5 BP 526 EP 533 PG 8 WC Hematology; Peripheral Vascular Disease SC Hematology; Cardiovascular System & Cardiology GA JX386 UT WOS:A1992JX38600008 PM 1455399 ER PT J AU ITTARAT, I WEBSTER, HK YUTHAVONG, YY AF ITTARAT, I WEBSTER, HK YUTHAVONG, YY TI HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC DETERMINATION OF DIHYDROOROTATE DEHYDROGENASE OF PLASMODIUM-FALCIPARUM AND EFFECTS OF ANTIMALARIALS ON ENZYME-ACTIVITY SO JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS LA English DT Article ID CULTURE; CONVERSION; INHIBITION; OROTATE; BERGHEI; INVITRO AB A reversed-phase high-performance liquid chromatographic technique for the determination of dihydroorotate dehydrogenase in Plasmodium falciparum was developed. The assay was applied to the evaluation of the effects of several antimalarial drugs on the enzyme. Treatment of both the asexual and gametocyte stages of P. falciparum in culture with menoctone, primaquine or the primaquine derivative WR 238605 led to depression of the enzyme activity, although the drugs did not appear to inhibit the enzyme directly. C1 MAHIDOL UNIV,FAC SCI,DEPT BIOCHEM,RAMA 6 RD,BANGKOK 10400,THAILAND. ARMED FORCES RES INST MED SCI,DEPT IMMUNOL & BIOCHEM,BANGKOK 10400,THAILAND. NR 21 TC 9 Z9 9 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-4347 J9 J CHROMATOGR-BIOMED JI J. Chromatogr.-Biomed. Appl. PD NOV 6 PY 1992 VL 582 IS 1-2 BP 57 EP 64 DI 10.1016/0378-4347(92)80302-7 PG 8 WC Chemistry, Analytical SC Chemistry GA JX778 UT WOS:A1992JX77800009 PM 1491058 ER PT J AU CRAMER, CJ TRUHLAR, DG AF CRAMER, CJ TRUHLAR, DG TI WHAT CAUSES AQUEOUS ACCELERATION OF THE CLAISEN REARRANGEMENT SO JOURNAL OF THE AMERICAN CHEMICAL SOCIETY LA English DT Article ID DIELS-ALDER REACTIONS; SEMIEMPIRICAL METHODS; GROUND-STATES; SOLVENT; OPTIMIZATION; PARAMETERS; MODEL; MECHANISM; MOLECULES; ETHERS AB We report the results of applying a new self-consistent-field solvation model to the Claisen rearrangement of allyl vinyl ether, all Possible methoxy-substituted derivatives, two alkylated derivatives, and one carboxymethylated derivative in order to understand the effects of aqueous solvation on the reaction rates. We have employed the AM1-SM2 version of the model to calculate the changes in free energies of solvation in passing from the lowest-energy conformations of the starting materials to both chair and boat transition states. The hydrophobic effect is always accelerative but always small and not very structure sensitive. Other first-hydration-shell effects attributable to hydrophilic parts of the reagents are more sensitive to the substitution pattern. The polarization contributions to the activation energies are usually larger. A favorable polarization contribution is found to be associated with efficient sequestration of charges of opposite sign into separated regions of space. We conclude that aqueous acceleration of the Claisen rearrangement is caused by electric polarization and first-hydration-shell hydrophilic effects, with the relative magnitudes and even the signs of these effects being quite sensitive to substitution pattern. C1 UNIV MINNESOTA,DEPT CHEM,MINNEAPOLIS,MN 55455. UNIV MINNESOTA,INST SUPERCOMP,MINNEAPOLIS,MN 55455. RP CRAMER, CJ (reprint author), USA,CTR CHEM RES DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010, USA. RI Truhlar, Donald/G-7076-2015; Cramer, Christopher/B-6179-2011 OI Truhlar, Donald/0000-0002-7742-7294; Cramer, Christopher/0000-0001-5048-1859 NR 40 TC 71 Z9 71 U1 0 U2 3 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0002-7863 J9 J AM CHEM SOC JI J. Am. Chem. Soc. PD NOV 4 PY 1992 VL 114 IS 23 BP 8794 EP 8799 DI 10.1021/ja00049a007 PG 6 WC Chemistry, Multidisciplinary SC Chemistry GA JW797 UT WOS:A1992JW79700007 ER PT J AU TEDESCO, JW ROSSON, BT MELBY, JA AF TEDESCO, JW ROSSON, BT MELBY, JA TI STATIC STRESSES IN DOLOS CONCRETE ARMOR UNITS SO COMPUTERS & STRUCTURES LA English DT Article AB Concrete amor units are commonly employed for the protection of shorelines and rubble structures. A three-dimensional finite element model is used to determine the states of static stress in dolosse with varying dimensions and concrete properties. An analytical procedure is developed which accurately predicts the tensile stress in the shank and horizontal fluke of a simply supported dolos subject to self-weight loading. Several numerical examples are presented which illustrate the application of prediction and iso-stress equations. C1 USA,ENGINEERS WATERWAYS EXPT STN,COASTAL ENGN RES CTR,VICKSBURG,MS 39108. UNIV NEBRASKA,DEPT CIVIL ENGN,LINCOLN,NE 68588. RP TEDESCO, JW (reprint author), AUBURN UNIV,DEPT CIVIL ENGN,AUBURN,AL 36849, USA. NR 12 TC 1 Z9 1 U1 1 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0045-7949 J9 COMPUT STRUCT JI Comput. Struct. PD NOV 3 PY 1992 VL 45 IS 4 BP 733 EP 743 DI 10.1016/0045-7949(92)90491-H PG 11 WC Computer Science, Interdisciplinary Applications; Engineering, Civil SC Computer Science; Engineering GA KA001 UT WOS:A1992KA00100011 ER PT J AU WEBER, DJ DANBERG, JE AF WEBER, DJ DANBERG, JE TI CORRELATION OF MEAN VELOCITY-MEASUREMENTS DOWNSTREAM OF A SWEPT BACKWARD-FACING STEP SO AIAA JOURNAL LA English DT Article AB The effect of backward-facing step sweep angle on the mean turbulent velocity field has been measured at subsonic speeds. A single component hot-film anemometer was used in a wind tunnel to measure the velocity normal and parallel to three 1.27-cm-high, backward-facing steps with sweep angles of 0, 15, and 30 deg. A swept step flowfield provides a useful and special test case for modelers of three-dimensional turbulent flows. This is illustrated here by testing the ability of Coles' wall-wake model and the Baldwin-Lomax viscosity model's ability to describe the measured profiles. The Coles profiles are applied to regions of attached flow. The effects of sweep angle on the wake parameter PI downstream of reattachment is strong. The experimental outer-flow velocities were used to evaluate the constants in a modified form of the Baldwin-Lomax model. The resulting constants were in fair to good agreement with the recommended values except downstream of reattachment. C1 USA,BALLIST RES LABS,COMPUTAT AERODYNAM BRANCH,ABERDEEN PROVING GROUND,MD 21005. RP WEBER, DJ (reprint author), USA,CTR CHEM RES DEV & ENGN,AERODYNAM RES & CONCEPTS ASSISTANCE BRANCH,ABERDEEN PROVING GROUND,MD 21010, USA. NR 13 TC 8 Z9 8 U1 0 U2 1 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091 SN 0001-1452 J9 AIAA J JI AIAA J. PD NOV PY 1992 VL 30 IS 11 BP 2701 EP 2706 DI 10.2514/3.11287 PG 6 WC Engineering, Aerospace SC Engineering GA JV780 UT WOS:A1992JV78000017 ER PT J AU MCCUTCHAN, FE HEGERICH, PA BRENNAN, TP PHANUPHAK, P SINGHARAJ, P JUGSUDEE, A BERMAN, PW GRAY, AM FOWLER, AK BURKE, DS AF MCCUTCHAN, FE HEGERICH, PA BRENNAN, TP PHANUPHAK, P SINGHARAJ, P JUGSUDEE, A BERMAN, PW GRAY, AM FOWLER, AK BURKE, DS TI GENETIC-VARIANTS OF HIV-1 IN THAILAND SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; ENVELOPE GLYCOPROTEIN; NEUTRALIZATION; RETROVIRUS; IDENTIFICATION; ANTIBODIES; BLOOD; AIDS AB Serosurveys conducted prior to 1988 indicated a very low level of HIV-1 infection in Thailand, even among high-risk groups. The Ministry of Health has reported a dramatic increase in HIV-1 infection during the last three years. The geographic and demographic distribution of the epidemic is broad, involving multiple provinces and risk groups. Foci of higher incidence and prevalence have been noted in the urban center of Bangkok and in the northern provinces of Chiang Mai and Chiang Rai. Here we report the results of genetic characterization of 16 HIV-1 isolates from Thailand using a combination of polymerase chain reaction (PCR) typing and DNA sequencing. The complete sequence of gp160 (env) of rive isolates, partial env sequence of six additional isolates, and the gag gene of two isolates were determined. Two highly distinct HIV-1 variants were found. One variant resembled those prevalent in North America and Europe; five of the isolates were of this type. The remaining eleven isolates were very similar to one another and represented a variant unlike any previously described. Phylogenetic tree analysis of complete env and gag genes placed the two variants on widely separated branches. Protein sequence comparisons indicate both general and specific features that distinguish the Northern Thailand variant both from the Bangkok variant and from virtually all previously sequenced HIV-1 isolates. A simple PCR test for distinguishing the two variants has been developed for use in epidemiologic surveys. C1 CHULALONGKORN UNIV,FAC MED,BANGKOK 5,THAILAND. ARMED FORCES RES INST MED SCI,BANGKOK 10400,THAILAND. SRA LABS INC,ROCKVILLE,MD 20850. GENENTECH INC,DEPT IMMUNOL,S SAN FRANCISCO,CA 94080. WALTER REED ARMY INST RES,DIV RETROVIROL,WASHINGTON,DC 20307. ROYAL THAI ARMY,INST PATHOL,BANGKOK 10400,THAILAND. RP MCCUTCHAN, FE (reprint author), HENRY M JACKSON FDN,RES LAB,1500 E GUDE DR,ROCKVILLE,MD 20850, USA. OI /0000-0002-5704-8094 NR 31 TC 229 Z9 239 U1 1 U2 1 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD NOV PY 1992 VL 8 IS 11 BP 1887 EP 1895 DI 10.1089/aid.1992.8.1887 PG 9 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA KC513 UT WOS:A1992KC51300007 PM 1489577 ER PT J AU SWAB, JJ SLAVIN, MJ QUINN, GD AF SWAB, JJ SLAVIN, MJ QUINN, GD TI FRACTURE ORIGINS IN ADVANCED STRUCTURAL CERAMICS SO AMERICAN CERAMIC SOCIETY BULLETIN LA English DT Article C1 NATL INST STAND & TECHNOL,GAITHERSBURG,MD 20899. RP SWAB, JJ (reprint author), USA,RES LAB,WATERTOWN SITE,WATERTOWN,MA 02172, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU AMER CERAMIC SOC PI WESTERVILLE PA 735 CERAMIC PLACE, PO BOX 6136, WESTERVILLE, OH 43081-6136 SN 0002-7812 J9 AM CERAM SOC BULL JI Am. Ceram. Soc. Bull. PD NOV PY 1992 VL 71 IS 11 BP 1639 EP 1640 PG 2 WC Materials Science, Ceramics SC Materials Science GA JZ036 UT WOS:A1992JZ03600004 ER PT J AU PREWITT, KC GAITHER, NS FARB, A WORTHAM, DC AF PREWITT, KC GAITHER, NS FARB, A WORTHAM, DC TI TRANSIENT ISCHEMIC ATTACKS AFTER LONG-TERM CLAMSHELL OCCLUDER IMPLANTATION FOR CLOSURE OF ATRIAL SEPTAL-DEFECT SO AMERICAN HEART JOURNAL LA English DT Note ID TRANSCATHETER CLOSURE; UMBRELLA CLOSURE C1 ARMED FORCES INST PATHOL,DEPT CARDIOVASC PATHOL,WASHINGTON,DC 20306. RP PREWITT, KC (reprint author), WALTER REED ARMY MED CTR,CARDIOL SERV,WASHINGTON,DC 20307, USA. NR 9 TC 16 Z9 16 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0002-8703 J9 AM HEART J JI Am. Heart J. PD NOV PY 1992 VL 124 IS 5 BP 1394 EP 1397 DI 10.1016/0002-8703(92)90437-Z PG 4 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA JW458 UT WOS:A1992JW45800048 PM 1442521 ER PT J AU WISWELL, TE FOSTER, NH SLAYTER, MV HACHEY, WE AF WISWELL, TE FOSTER, NH SLAYTER, MV HACHEY, WE TI MANAGEMENT OF A PIGLET MODEL OF THE MECONIUM ASPIRATION SYNDROME WITH HIGH-FREQUENCY OR CONVENTIONAL VENTILATION SO AMERICAN JOURNAL OF DISEASES OF CHILDREN LA English DT Article ID PERSISTENT PULMONARY-HYPERTENSION; MECHANICAL VENTILATION; JET VENTILATION; PERCUSSIVE VENTILATION; NEWBORN AB Objective.-To assess the usefulness of three methods of high-frequency ventilation in the early management of a piglet model of the meconium aspiration syndrome. Design.-Randomized, block design. Setting.-Animal research facility. Subjects.-Fifty-six mixed-breed newborn piglets aged 1 to 4 days and weighing 1.8 to 2.7 kg. Interventions.-After instillation of a 2.2-mL/kg solution of 25% meconium, 56 piglets were randomized to receive treatment with (1) a conventional positive-pressure infant ventilator, (2) the Bunnell Life Pulse high-frequency jet ventilator, (3) the Bird model VDR high-frequency flow interruptor, or (4) the Infant Star high-frequency flow interruptor. We adjusted ventilator settings to maintain partial pressures of arterial oxygen (PaO2) of 80 to 120 cm H2O and partial pressures of arterial carbon dioxide (PaCO2) of 30 to 50 cm H2O during the 6 hours of ventilation. Measurements and Main Results.-We compared pulmonary histologic alterations and four physiologic parameters: (1) mean airway pressure, (2) PacO2, (3) ratio of PaO2 to partial alveolar oxygen pressure (PAO2), and (4) oxygenation index ([(fraction of inspired oxygen)(mean airway pressure)(100)]/PaO2). The two measures of oxygenation were similar for all four devices except at 4 hours, when the PaO2/PAO2 ratio on positive-pressure ventilation was significantly higher than that on high-frequency jet ventilation (P=.008). The histologic changes on positive-pressure ventilation (atelectasis, inflammation, presence of meconium, and exudative debris) were significantly worse than those on high-frequency jet ventilation or flow interruption (P<.0001). Conclusions.-The finding of less severe pathologic alterations with various types of high-frequency ventilators justifies further investigations into the management of the meconium aspiration syndrome with these devices. C1 WALTER REED ARMY INST RES,WASHINGTON,DC 20307. ARMED FORCES INST PATHOL,WASHINGTON,DC 20306. RP WISWELL, TE (reprint author), WALTER REED ARMY MED CTR,DEPT PEDIAT,6825 16TH ST NW,WASHINGTON,DC 20307, USA. NR 22 TC 31 Z9 33 U1 0 U2 1 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0002-922X J9 AM J DIS CHILD JI Am. J. Dis. Child. PD NOV PY 1992 VL 146 IS 11 BP 1287 EP 1293 PG 7 WC Pediatrics SC Pediatrics GA JX323 UT WOS:A1992JX32300011 PM 1415063 ER PT J AU KADAKIA, SC CASSADAY, M SHAFFER, RT AF KADAKIA, SC CASSADAY, M SHAFFER, RT TI PROSPECTIVE EVALUATION OF FOLEY CATHETER AS A REPLACEMENT GASTROSTOMY TUBE SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Article ID SMALL-BOWEL OBSTRUCTION; DUODENAL OBSTRUCTION; BUTTON; MIGRATION AB Percutaneous endoscopic gastrostomy provides a nonsurgical alternative to enteral feeding. However, the percutaneous endoscopic gastrostomy tube may deteriorate, malfunction, or be accidentally expelled from the stomach, requiring replacement. This prospective study was performed to evaluate the use of an all silicone Foley catheter (Foley) as a replacement feeding gastrostomy in 28 patients requiring replacement gastrostomy. A plastic ring and a retention disc were always placed over the Foley prior to replacement. Foley functioned well without replacement in 19 (68%) patients for a mean of 167 days. It needed to be replaced in nine (32%) patients due to malfunction after a mean of 138 days. Lack of migration of Foley was the most striking finding of our study, in contrast to case reports in the literature. These data suggest that Foley can be safely used as replacement gastrostomy tube. A randomized controlled trial comparing the Foley catheter as a replacement tube with other commercially available devices is needed. RP KADAKIA, SC (reprint author), BROOKE ARMY MED CTR,DEPT MED,GASTROENTEROL SERV,FT SAM HOUSTON,TX 78234, USA. NR 19 TC 12 Z9 12 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD NOV PY 1992 VL 87 IS 11 BP 1594 EP 1597 PG 4 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA JX319 UT WOS:A1992JX31900014 PM 1442680 ER PT J AU MURRAY, RN KADAKIA, SC PARKER, A AF MURRAY, RN KADAKIA, SC PARKER, A TI GUIDEWIRE LOOP FORMATION IN COMMON BILE-DUCT DURING BILIARY MANOMETRY SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Letter ID ODDI DYSFUNCTION; SPHINCTER; CATHETER C1 BROOKE ARMY MED CTR,DEPT MED,GASTROENTEROL SERV,FT SAM HOUSTON,TX 78234. NR 7 TC 4 Z9 4 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD NOV PY 1992 VL 87 IS 11 BP 1679 EP 1681 PG 3 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA JX319 UT WOS:A1992JX31900037 PM 1442704 ER PT J AU SARIBANSOHRABY, S ABRAMOW, M FISHER, RS AF SARIBANSOHRABY, S ABRAMOW, M FISHER, RS TI SINGLE-CHANNEL BEHAVIOR OF A PURIFIED EPITHELIAL NA+ CHANNEL SUBUNIT THAT BINDS AMILORIDE SO AMERICAN JOURNAL OF PHYSIOLOGY LA English DT Note DE PATCH CLAMP; SODIUM TRANSPORT; PROTEIN PURIFICATION; ELECTROPHYSIOLOGY; ION CHANNELS; BEEF PAPILLA; A6 CULTURED CELLS; EPITHELIUM ID SENSITIVE SODIUM-CHANNEL; APICAL MEMBRANE; XENOPUS OOCYTES; PURIFICATION; RECONSTITUTION; EXPRESSION; PROTEIN; CELLS AB The apical membrane of high electrical resistance epithelia, which is selectively permeable to Na+, plays an essential role in the maintenance of salt balance. Na+ entry from the apical fluid into the cells is mediated by amiloride-blockable Na+-specific channels. The channel protein, purified from both amphibian and mammalian sources, is composed of several subunits, only one of which, the 150-kDa polypeptide, specifically binds the Na+ transport inhibitor amiloride. The goal of the present study was to investigate whether the isolated amiloride-binding subunit of the channel could conduct Na+. The patch-clamp technique was used to study the 150-kDa polypeptide incorporated into a lipid bilayer formed on the tip of a glass pipette. Unitary conductance jumps averaged 4.8 pS at 100 mM Na2HPO4. Open times ranged from 24 ms to several seconds. The channel spent most of the time in the closed state. Channel conductance and gating were independent of voltage between -60 and +100 mV. Amiloride (0.1 muM) decreased the mean open time of the channel by 98%. We conclude that the 150-kDa subunit of the amiloride-blockable Na+ channel conducts current and may be sufficient for the Na+ transport function of the whole channel. C1 WALTER REED ARMY INST RES,DEPT NEPHROL,WASHINGTON,DC 20307. UNIV LIBRE BRUXELLES,PHYSIOL LAB,B-1070 BRUSSELS,BELGIUM. NR 27 TC 23 Z9 23 U1 0 U2 0 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0002-9513 J9 AM J PHYSIOL JI Am. J. Physiol. PD NOV PY 1992 VL 263 IS 5 BP C1111 EP C1117 PN 1 PG 7 WC Physiology SC Physiology GA JZ778 UT WOS:A1992JZ77800024 ER PT J AU KNAPIK, JJ JONES, BH REYNOLDS, KL STAAB, JS AF KNAPIK, JJ JONES, BH REYNOLDS, KL STAAB, JS TI VALIDITY OF SELF-ASSESSED PHYSICAL-FITNESS SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE LA English DT Article AB This study compared self-ratings of components of physical fitness with objective measures of physical fitness. We made comparisons in two groups of male infantry soldiers (n = 96 and n = 276) and one group of older male military officers (n = 241). To obtain self-ratings of physical fitness, we asked subjects, ''Compared to others of your age and sex, how would you rate your (a) endurance, (b) sprint speed, (c) strength, (d) flexibility?'' Subjects responded to each of the four questions on a five-point scale. Self-ratings of endurance were systematically related to three measures of aerobic capacity, including VO2max peak VO2, and two-mile run time (r = 0.29 to 0.53). Self-ratings of sprint speed showed only weak relationships to measures of anaerobic capacity assessed by the Wingate test, pushups, and sit-ups (r = 0.10 to 0.17). Strength ratings were systematically related to measures of maximal strength (r = 0.28 to 0.53). Upper body strength measures were more closely associated with the self-ratings of strength than were measures of lower body strength. Responses to the flexibility question were systematically related to measures of hip/low back flexibility (r = 0.30 and 0.48) but not to other measures of flexibility. Apparently, physically active subjects can approximately classify their aerobic capacity, muscle strength, and some types of flexibility. RP KNAPIK, JJ (reprint author), USA,ENVIRONM MED RES INST,DIV OCCUPAT MED,NATICK,MA 01760, USA. NR 0 TC 13 Z9 15 U1 0 U2 6 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 SN 0749-3797 J9 AM J PREV MED JI Am. J. Prev. Med. PD NOV-DEC PY 1992 VL 8 IS 6 BP 367 EP 372 PG 6 WC Public, Environmental & Occupational Health; Medicine, General & Internal SC Public, Environmental & Occupational Health; General & Internal Medicine GA KD423 UT WOS:A1992KD42300006 PM 1482577 ER PT J AU BARTELS, JW BURGESS, LPA AF BARTELS, JW BURGESS, LPA TI NASAL DORSAL PSEUDOCYST FORMATION AFTER RHINOPLASTY SO AMERICAN JOURNAL OF RHINOLOGY LA English DT Article ID CYST AB Nasal dorsal cyst or pseudocyst formation is a rare complication after rhinoplasty. We present what we believe to be the first case in which extensive bony destruction resulted from such a lesion. A review of the literature is provided along with a discussion of possible etiologies of this complication. RP BARTELS, JW (reprint author), TRIPLER ARMY MED CTR,DEPT SURG,OTOLARYNGOL HEAD & NECK SURG SERV,HONOLULU,HI 96859, USA. NR 5 TC 1 Z9 1 U1 0 U2 0 PU OCEAN SIDE PUBLICATIONS INC PI PROVIDENCE PA 95 PITMAN ST, PROVIDENCE, RI 02906 SN 1050-6586 J9 AM J RHINOL JI Am. J. Rhinol. PD NOV-DEC PY 1992 VL 6 IS 6 BP 199 EP 201 DI 10.2500/105065892781976682 PG 3 WC Otorhinolaryngology SC Otorhinolaryngology GA KK572 UT WOS:A1992KK57200002 ER PT J AU STEVENS, EL UYEHARA, CFT SOUTHGATE, WM NAKAMURA, KT AF STEVENS, EL UYEHARA, CFT SOUTHGATE, WM NAKAMURA, KT TI FUROSEMIDE DIFFERENTIALLY RELAXES AIRWAY AND VASCULAR SMOOTH-MUSCLE IN FETAL, NEWBORN, AND ADULT GUINEA-PIGS SO AMERICAN REVIEW OF RESPIRATORY DISEASE LA English DT Article ID INHALED FUROSEMIDE; INDUCED BRONCHOCONSTRICTION; RELAXATION; FRUSEMIDE; INFANTS AB Furosemide, an inhibitor of Cl-dependent Na+,K+ cotransport, is the most frequently used diuretic in newborns. Recently, furosemide was also demonstrated to decrease bronchial hyperresponsiveness in adults, although little is known about the direct effect of furosemide on smooth muscle of Immature animals. This in vitro study was designed to determine the action of furosemide on airway and vascular smooth muscle during ontogeny. Extrathoracic trachea (ET), main stem bronchi, main pulmonary artery, and thoracic aorta ring segments from fetal, newborn, and adult Hartley albino guinea pigs were suspended in HEPES solution for measurement of isometric tension. Furosemide (30 or 300 muM) was administered after preconstriction with an ED35-70 concentration of histamine or acetylcholine for airway and ED40-100 concentration of norepinephrine for vessels. Furosemide (30 muM) caused significant relaxation of airway smooth muscle at all ages. After histamine-induced preconstriction, fetal airway segments exhibited greatest relaxation (183 +/- 28%), with newborn airway demonstrating 123 +/- 15% relaxation and modest relaxation seen in adults (40 +/- 4%). This pattern was similar for both ET and bronchus and appeared greater for histamine compared with ACh preconstriction. Epithelial removal slightly enhanced relaxation. Furosemide also relaxed pulmonary artery segments, but at a 10-fold higher concentration. In striking contrast to the pattern seen in airway, adult pulmonary artery relaxed more than newborn and newborn, more than fetus. Cyclooxygenase blockade and endothelium removal did not change pulmonary artery relaxation. Furosemide did not significantly relax aorta after NE preconstriction. Taken together, these results suggest that furosemide may be more effective in relaxing airway compared with vascular smooth muscle, and the ontogeny of these responses indicates a greater efficacy and selectivity in airways of immature animals. C1 KAPIOLANI MED CTR WOMEN & CHILDREN,JOHN A BURNS SCH MED,DEPT PEDIAT,1319 PUNAHOU ST,ROOM 731,HONOLULU,HI 96826. TRIPLER ARMY MED CTR,DEPT CLIN INVEST,HONOLULU,HI 96859. TRIPLER ARMY MED CTR,DEPT PEDIAT,HONOLULU,HI 96859. FU NHLBI NIH HHS [HL-45220] NR 23 TC 32 Z9 32 U1 0 U2 1 PU AMER LUNG ASSOC PI NEW YORK PA 1740 BROADWAY, NEW YORK, NY 10019 SN 0003-0805 J9 AM REV RESPIR DIS JI Am. Rev. Respir. Dis. PD NOV PY 1992 VL 146 IS 5 BP 1192 EP 1197 PG 6 WC Respiratory System SC Respiratory System GA JZ712 UT WOS:A1992JZ71200013 PM 1443869 ER PT J AU WILLIAMSON, KC DUFFY, PE KASLOW, DC AF WILLIAMSON, KC DUFFY, PE KASLOW, DC TI IMMUNOAFFINITY CHROMATOGRAPHY USING ELECTROELUTION SO ANALYTICAL BIOCHEMISTRY LA English DT Article ID TRANSMISSION-BLOCKING ANTIBODIES; PLASMODIUM-GALLINACEUM; MONOCLONAL-ANTIBODIES; SURFACE PROTEIN; MALARIA; TARGET; ANTIGENS; IMMUNITY C1 WALTER REED ARMY INST RES,DEPT MED,WASHINGTON,DC 20307. RP WILLIAMSON, KC (reprint author), NIAID,MALARIA RES LAB,BETHESDA,MD 20892, USA. NR 13 TC 4 Z9 4 U1 0 U2 0 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0003-2697 J9 ANAL BIOCHEM JI Anal. Biochem. PD NOV PY 1992 VL 206 IS 2 BP 359 EP 362 DI 10.1016/0003-2697(92)90378-K PG 4 WC Biochemical Research Methods; Biochemistry & Molecular Biology; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA JW129 UT WOS:A1992JW12900023 PM 1443606 ER PT J AU MARKAKIS, DA SAYSON, SC SCHREINER, MS AF MARKAKIS, DA SAYSON, SC SCHREINER, MS TI INSERTION OF THE LARYNGEAL MASK AIRWAY IN AWAKE INFANTS WITH THE ROBIN SEQUENCE SO ANESTHESIA AND ANALGESIA LA English DT Article ID ANESTHESIA; LARYNGOSCOPY C1 UNIV PENN,CHILDRENS HOSP,SCH MED,DEPT ANESTHESIOL & CRIT CARE MED,34TH ST & CIV CTR BLVD,PHILADELPHIA,PA 19104. BROOKE ARMY MED CTR,SAN ANTONIO,TX. NR 14 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0003-2999 J9 ANESTH ANALG JI Anesth. Analg. PD NOV PY 1992 VL 75 IS 5 BP 823 EP 824 PG 2 WC Anesthesiology SC Anesthesiology GA JV698 UT WOS:A1992JV69800030 ER PT J AU NOEL, GL HERBERS, JE CAPLOW, MP COOPER, GS PANGARO, LN HARVEY, J AF NOEL, GL HERBERS, JE CAPLOW, MP COOPER, GS PANGARO, LN HARVEY, J TI HOW WELL DO INTERNAL-MEDICINE FACULTY MEMBERS EVALUATE THE CLINICAL SKILLS OF RESIDENTS SO ANNALS OF INTERNAL MEDICINE LA English DT Article DE INTERNSHIP AND RESIDENCY; FACULTY, MEDICAL; CLINICAL COMPETENCE; VIDEOTAPE RECORDING; PHYSICAL EXAMINATION ID STANDARDIZED PATIENTS; SURGICAL RESIDENTS; SIMULATED PATIENTS; 4TH-YEAR STUDENTS; AMERICAN-BOARD; PERFORMANCE; COMPETENCE; CERTIFICATION; RELIABILITY; PROGRAM AB Objective: To determine the accuracy of faculty evaluations of residents' clinical skills and whether a structured form and instructional videotape improve accuracy. Design: Randomized, controlled trial. Setting. Twelve university and community teaching hospitals. Participants: A total of 203 faculty internists. Interventions: Participants watched a videotape of one of two residents performing new patient workups. Participants were assigned to one of three groups: They used either an open-ended evaluation form or a structured form that prompted detailed observations; some participants used the structured form after seeing a videotape showing good evaluation techniques. Main Outcome Measures: Faculty observations of strengths and weaknesses in the residents' performance were scored. An accuracy score consisting of clinical skills of critical importance for a competent history and physical examination was calculated for each participant by raters blinded to the participants' hospital, training, subspecialty, and experience as observers. Results: When observations were not prompted, participants recorded only 30% of the residents' strengths and weaknesses; accuracy among participants using structured forms increased to 60% or greater. Faculty in university hospitals were more accurate than those in community hospitals, and general internists were more accurate than subspecialists; the structured form improved performance in all groups. However, participants disagreed markedly about the residents' overall clinical competence: Thirty-one percent assessed one resident's clinical skills as unsatisfactory or marginal, whereas 69% assessed them as satisfactory or superior; 48% assessed the other resident's clinical skills as unsatisfactory or marginal, whereas 52% assessed them as satisfactory or superior. Participants also disagreed about the residents' humanistic qualities. The instructional videotape did not improve accuracy. Conclusions: A structured form improved the accuracy of observations of clinical skills, but faculty still disagreed in their assessments of clinical competence. If program directors are to certify residents' clinical competence, better and more standardized evaluation is needed. C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. UNIV N CAROLINA,CHAPEL HILL,NC 27514. DARTMOUTH COLL,HITCHCOCK MED CTR,DARTMOUTH MED SCH,HANOVER,NH 03756. UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. NR 36 TC 133 Z9 137 U1 0 U2 7 PU AMER COLL PHYSICIANS PI PHILADELPHIA PA INDEPENDENCE MALL WEST 6TH AND RACE ST, PHILADELPHIA, PA 19106-1572 SN 0003-4819 J9 ANN INTERN MED JI Ann. Intern. Med. PD NOV 1 PY 1992 VL 117 IS 9 BP 757 EP 765 PG 9 WC Medicine, General & Internal SC General & Internal Medicine GA JV424 UT WOS:A1992JV42400009 PM 1343207 ER PT J AU CORTESE, LM GASSER, RA BJORNSON, DC DACEY, MJ OSTER, CN AF CORTESE, LM GASSER, RA BJORNSON, DC DACEY, MJ OSTER, CN TI PROLONGED RECURRENCE OF PENTAMIDINE-INDUCED TORSADES-DE-POINTES SO ANNALS OF PHARMACOTHERAPY LA English DT Article ID PNEUMOCYSTIS-CARINII PNEUMONIA; DE-POINTES; VENTRICULAR-TACHYCARDIA; THERAPY; ISETHIONATE; AIDS AB OBJECTIVE: To report a case of recurrent pentamidine-induced torsades de pointes (TdP) and to review previously reported cases in the literature. DATA SOURCES: Medical records of the subject patient, case reports, and relevant studies identified by MEDLINE. DATA EXTRACTION: Data were abstracted from pertinent published sources by one author and reviewed by the remaining authors. DATA SYNTHESIS: A 43-year-old woman with AIDS experienced pentamidine-induced TdP. TdP and other cardiac arrhythmias recurred repeatedly for 13 days after pentamidine therapy was discontinued and in the presence of normal magnesium and potassium serum concentrations. Infusions of magnesium, lidocaine, and isoproterenol were used to treat the arrhythmias. The exact mechanism of pentamidine-induced TdP has not been clearly established. It is postulated, however, that the similarity of pentamidine's structure to procainamide may contribute to its proarrhythmic effects. The tissue-binding capacity of pentamidine may result in a prolongation of its effects. No distinctive characteristic appears to predispose people to the development of cardiac arrhythmias. Laboratory values that should be monitored include serum magnesium, potassium, and creatinine. The corrected QT interval also should be monitored. CONCLUSIONS: Recurrent arrhythmias may be seen for many days after intravenous administration of pentamidine has been discontinued. Clinicians should consider this phenomenon as they decide how to monitor patients who have received this drug. C1 WALTER REED ARMY MED CTR,INFECT DIS SERV,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,INTERNAL MED SERV,WASHINGTON,DC 20307. RP CORTESE, LM (reprint author), WALTER REED ARMY MED CTR,HENRY M JACKSON FDN,BLDG 1,WARD 11,WASHINGTON,DC 20307, USA. NR 14 TC 19 Z9 21 U1 0 U2 0 PU HARVEY WHITNEY BOOKS CO PI CINCINNATI PA PO BOX 42696, CINCINNATI, OH 45242 SN 1060-0280 J9 ANN PHARMACOTHER JI Ann. Pharmacother. PD NOV PY 1992 VL 26 IS 11 BP 1365 EP 1369 PG 5 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA JW728 UT WOS:A1992JW72800004 PM 1477438 ER PT J AU JOHNSON, RC ROSENMEIER, GJ KEELING, JH AF JOHNSON, RC ROSENMEIER, GJ KEELING, JH TI A PAINFUL STEP - ECCRINE POROMA SO ARCHIVES OF DERMATOLOGY LA English DT Note C1 BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234. RP JOHNSON, RC (reprint author), UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814, USA. NR 13 TC 9 Z9 9 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0003-987X J9 ARCH DERMATOL JI Arch. Dermatol. PD NOV PY 1992 VL 128 IS 11 BP 1533 EP & PG 0 WC Dermatology SC Dermatology GA JX149 UT WOS:A1992JX14900015 ER PT J AU LANDRY, FJ PARKER, JM PHILLIPS, YY AF LANDRY, FJ PARKER, JM PHILLIPS, YY TI OUTCOME OF CARDIOPULMONARY-RESUSCITATION IN THE INTENSIVE-CARE SETTING SO ARCHIVES OF INTERNAL MEDICINE LA English DT Article ID APACHE-II; UNIT; SURVIVAL AB Background.-Although cardiopulmonary resuscitation (CPR) has been shown to be most effective in a monitored setting, previous studies have focused primarily on patients with acute cardiac events rather than chronic progressive disease. This study examined the outcome of CPR in the medical and surgical intensive care units where patients often have acute illness superimposed on chronic underlying conditions. Methods.-We present a retrospective chart review of all patients undergoing CPR in medical and surgical intensive care units during a 2-year period. Results.-One hundred fourteen charts were reviewed. Patient mean age was 59 years. The primary underlying disease was malignancy in 29 (25%), vascular disease in 20 (18%), chronic liver disease in eight (7%), end-stage renal disease in six (5%), chronic obstructive pulmonary disease in five (5%), and other conditions in 46 (40%) patients. Although 50 (44%) of the patients were initially resuscitated, only six (5%) ultimately survived to hospital discharge. Only one of 29 patients with malignancy and one of 39 septic patients survived. Age, sex, and Acute Physiology and Chronic Health Evaluation II scores were similar among survivors and nonsurvivors. Furthermore, four of the six survivors died within 1 year of discharge, and the two others had severe disabilities. Conclusions.-Patients with chronic medical conditions undergoing CPR even in an intensive care unit setting seldom survive to hospital discharge. Even among the few survivors, the near term prognosis is poor. Therefore, the decision to perform CPR should take into account underlying chronic medical conditions and not merely the setting of the arrest. C1 WALTER REED ARMY MED CTR,DEPT MED,WASHINGTON,DC 20307. RP LANDRY, FJ (reprint author), WALTER REED ARMY MED CTR,DEPT INTERNAL MED 7E,WASHINGTON,DC 20307, USA. NR 19 TC 72 Z9 75 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0003-9926 J9 ARCH INTERN MED JI Arch. Intern. Med. PD NOV PY 1992 VL 152 IS 11 BP 2305 EP 2308 DI 10.1001/archinte.152.11.2305 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA JX151 UT WOS:A1992JX15100019 PM 1444691 ER PT J AU KOPLOVITZ, I GRESHAM, VC DOCHTERMAN, LW KAMINSKIS, A STEWART, JR AF KOPLOVITZ, I GRESHAM, VC DOCHTERMAN, LW KAMINSKIS, A STEWART, JR TI EVALUATION OF THE TOXICITY, PATHOLOGY, AND TREATMENT OF CYCLOHEXYLMETHYLPHOSPHONOFLUORIDATE (CMPF) POISONING IN RHESUS-MONKEYS SO ARCHIVES OF TOXICOLOGY LA English DT Article DE ORGANOPHOSPHATE; RHESUS; OXIMES; ATROPINE; CARBAMATES ID SOMAN; PROTECTION; ATROPINE; ANIMALS; THERAPY; HI-6 AB Cyclohexylmethylphosphonofluoridate (CMPF) is an organophosphate cholinesterase inhibitor with military significance. The purpose of these studies was 1) to determine the acute toxicity of CMPF in the male rhesus monkey, 2) to evaluate the efficacy of pyridostigmine (PYR) pretreatment plus atropine and oxime (2-PAM or HI6) treatment, and 3) to evaluate the pathological consequences of acute poisoning. An i. m. LD50 of CMPF was estimated using an up-and-down dose selection procedure and 12 animals. The 48-h and 7-day LD50 was 46.6 mug/kg, i. m. In the protection experiments, pyridostigmine (0.30. 7 mg/kg/24 h) was administered by surgically implanted osmotic minipumps for 3-12 days resulting in 21-65% inhibition of erythrocyte acetylcholinesterase activity. Animals were challenged with 5 x LD50 CMPF (233 mug/kg) and treated with atropine (0.4 mg/kg) and either 2-PAM (25.7 mg/kg) or HI6 (37.8 mg/kg) at the onset of signs or 1 min after challenge. Osmotic pumps were removed within 30 min after agent challenge. Pyridostigmine, atropine, and either 2-PAM or HI6 were completely effective against CMPF, saving ten of ten animals in each group. In comparison, three of five animals challenged with 5 x LD50 of soman and treated with atropine and 2-PAM survived 7 days. The primary histologic lesions in the acute toxicity group were neuronal degeneration/necrosis and spinal cord hemorrhage. The CMPF treated groups (total of 20 animals) had minimal nervous system changes with no significant lesion difference resulting from the different oxime therapies. The primary non-neural lesions were degenerative cardiomyopathy and skeletal muscle degeneration which occasionally progressed to necrosis and mineralization. The results indicate that PYR pretreatment in conjunction with atropine and oxime treatment is an effective regimen against battlefield relevant levels (5 x LD50) of CMPF. RP KOPLOVITZ, I (reprint author), USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010, USA. NR 20 TC 35 Z9 35 U1 1 U2 4 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0340-5761 J9 ARCH TOXICOL JI Arch. Toxicol. PD NOV PY 1992 VL 66 IS 9 BP 622 EP 628 DI 10.1007/BF01981500 PG 7 WC Toxicology SC Toxicology GA JW630 UT WOS:A1992JW63000002 PM 1482284 ER PT J AU LOW, LL CERVANTES, AG MELCHER, WL AF LOW, LL CERVANTES, AG MELCHER, WL TI TOPHACEOUS GOUT AS A FUNGATING MASS SO ARTHRITIS AND RHEUMATISM LA English DT Note C1 KAISER PERMANENTE MED GRP,WALNUT CREEK,CA. TRIPLER ARMY MED CTR,HONOLULU,HI 96859. RP LOW, LL (reprint author), WALTER REED ARMY MED CTR,WASHINGTON,DC 20307, USA. NR 6 TC 5 Z9 6 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0004-3591 J9 ARTHRITIS RHEUM JI Arthritis Rheum. PD NOV PY 1992 VL 35 IS 11 BP 1399 EP 1400 PG 2 WC Rheumatology SC Rheumatology GA JW730 UT WOS:A1992JW73000026 PM 1445464 ER PT J AU DUBOSE, DA AGNEW, JW AF DUBOSE, DA AGNEW, JW TI SEASONAL EFFECTS ON HUMAN PHYSIOLOGICAL ADAPTATION FACTORS, THERMOTOLERANCE AND PLASMA FIBRONECTIN SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article ID HEAT-STRESS MORTALITY; TRAUMA; DEFICIENCY; INJURY; BLOOD AB Plasma fibronectin (PF) influences shock survival and basal levels increase with active conditioning that improves human physiological adaptation factors (PAF) and thermotolerance (TT). To evaluate further PF's relationship with PAF and TT, the effects of passive conditioning with seasonal change (spring vs. summer) in New England on PAF, TT, basal PF level and PF level during hot-humid exercise (HHE; bicycling; 40 +/- 4% VO2max; 35-degrees-C; 70% rh; 45 min) were examined in male subjects (28.2 +/-1.6 years; N = 7; values are means +/- SE). The spring and summer studies were separated by 2 months. In addition, 2 months prior to the spring study, a winter basal PF pre-screening was conducted. Winter (287 +/- 36 mug/ml), spring (272 +/- 21 mug/ml), and summer (278 +/- 19 mug/ml) basal PF levels were similar. The PF response during HHE was unremarkable with seasonal change. PAF were improved, since blood volume (6266 +/- 276 vs. 5895 +/-251 ml), plasma volume (3896 +/- 198 vs. 3601 +/- 165 ml) and HHE sweat rate (18.7 +/- 5.5 vs. 12.9 +/- 6.4 ml/min) were elevated (p < 0.05) in the summer compared to the spring. However, this was not accompanied by improved TT, since spring and summer rectal temperatures during HHE were similar, while summer heart rate was elevated (p < 0.05) compared to the spring. In contrast to active conditioning, passively-induced improvements in PAF were not associated with elevations in TT or PF level. Unlike PAF, PF elevations might only occur when the conditioning resulted in increased TT, which suggests a potential for PF as a TT marker. RP DUBOSE, DA (reprint author), USA,ENVIRONM MED RES INST,DIV CELLULAR PHYSIOL & PATHOL,ENVIRONM PATHOPHYSIOL DIRECTORATE,NATICK,MA 01760, USA. NR 25 TC 1 Z9 1 U1 0 U2 2 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD NOV PY 1992 VL 63 IS 11 BP 982 EP 985 PG 4 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA JV794 UT WOS:A1992JV79400007 PM 1445163 ER PT J AU BRUCKART, JE AF BRUCKART, JE TI RADIATED ELECTRIC-FIELD MEASUREMENTS IN UNITED-STATES-ARMY HELICOPTERS SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Note AB Aircraft systems and medical devices generate electromagnetic fields. Electromagnetic interference (EMI) can cause faulty operation of aircraft systems or medical devices and endanger patients or aircraft crewmembers. A ground and inflight study was conducted to describe the electromagnetic fields in typical operations. Broadband isotropic field sensors measured electric fields from 5 kHz to 3 MHz, 3 to 500 MHz, and 0.5 MHz to 6 GHz. Fields were measured at 0.5 m space intervals in JOH-58A, JUH-1H, and JUH-60A helicopters with systems off, operating RPM, 5-ft hover, 50-ft hover, and cruise. Electric fields in the environment were homogeneous and less than 0.1 V/m. Fields in the helicopters increased during ascent, but remained less than 2 V/m except during radio transmissions. EMI effect of the Physio Control Lifepack(R) 8 was demonstrated during FM radio transmission. The results are useful in evaluating electromagnetic emissions and predicting operations that may result in an in-flight malfunction of a medical device or aircraft system. RP BRUCKART, JE (reprint author), USA,AEROMED RES LAB,ARMY PROGRAM TEST & EVALUAT AEROMED EQUIPMENT,POB 577,FT RUCKER,AL 36362, USA. NR 7 TC 2 Z9 2 U1 0 U2 1 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD NOV PY 1992 VL 63 IS 11 BP 1019 EP 1023 PG 5 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA JV794 UT WOS:A1992JV79400014 PM 1445153 ER PT J AU SMITH, JD GORDON, RK BRUGH, SA CHIANG, PK AF SMITH, JD GORDON, RK BRUGH, SA CHIANG, PK TI INHIBITION OF THE INSULIN-INDUCED DIFFERENTIATION OF 3T3-L1 FIBROBLASTS INTO ADIPOCYTES BY PHOSPHONOLIPIDS SO BIOCHEMICAL ARCHIVES LA English DT Article ID RECEPTOR TYROSINE KINASE; PHOSPHONIC ACID; TETRAHYMENA; PHOSPHATIDYLETHANOLAMINE; PHOSPHATIDYLCHOLINE; RAT; SPHINGOSINE; BINDING AB Confluent 3T3-LI fibroblasts can be induced to differentiate into adipocytes by insulin. When the cells were first grown in the presence of 2-aminoethylphosphonate (AEP), in order to form 2-aminoethylphosphonoglyceride, the subsequent response to insulin was altered. From 15 to 21 days after induction of differentiation triglyceride accumulation in cells grown with 1 mM AEP was half of the value in cells treated with insulin alone. In cells grown with 5 mM or 10 mM AEP there was no triglyceride accumulation over that of control values, either with or without insulin. AEP had to be present in the cultures either during cell growth or subsequent differentiation of the cells for its effect to occur. 2-Aminoethylphosphonoglyceride comprised about 10% of the total phospholipids in the AEP-grown cells. Its formation was at the expense of both phosphatidylcholine and phosphatidylethanolamine which were reduced from 43% to 39% and from 24% to 18% of the total, respectively. However, there was no change in any of the minor phospholipids. The results suggest that, despite the structural similarity between phosphatidylethanolamine and 2-aminoethylphosphonoglyceride, the phosphonolipid can have profound effects on cellular function. C1 WALTER REED ARMY INST RES,DIV BIOCHEM,DEPT APPL BIOCHEM,WASHINGTON,DC 20307. RP SMITH, JD (reprint author), UNIV MASSACHUSETTS,DEPT CHEM,DARTMOUTH,MA 02747, USA. NR 28 TC 4 Z9 4 U1 0 U2 0 PU MBR PRESS INC PI KENYON PA PO BOX P, KENYON, MN 55946-000P SN 0749-5331 J9 BIOCHEM ARCH JI Biochem. Arch. PD NOV PY 1992 VL 8 IS 4 BP 339 EP 344 PG 6 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA JW670 UT WOS:A1992JW67000014 ER PT J AU MARCHAK, FM GOLDSTEIN, JD DESMOND, JL AF MARCHAK, FM GOLDSTEIN, JD DESMOND, JL TI TOWARD AN IMAGE SIMILARITY METRIC SO BULLETIN OF THE PSYCHONOMIC SOCIETY LA English DT Meeting Abstract C1 USA,LABCOM,WASHINGTON,DC 20310. NR 0 TC 0 Z9 0 U1 0 U2 0 PU PSYCHONOMIC SOC INC PI AUSTIN PA 1710 FORTVIEW RD, AUSTIN, TX 78704 SN 0090-5054 J9 B PSYCHONOMIC SOC PD NOV PY 1992 VL 30 IS 6 BP 452 EP 452 PG 1 WC Psychology, Mathematical SC Psychology GA JV167 UT WOS:A1992JV16700157 ER PT J AU MILLS, CB DIEHL, VA BIRKMIRE, DP MON, LC AF MILLS, CB DIEHL, VA BIRKMIRE, DP MON, LC TI RELATIONSHIP BETWEEN IMPORTANCE RATINGS AND RECALL FOR PROCEDURAL TEXTS SO BULLETIN OF THE PSYCHONOMIC SOCIETY LA English DT Meeting Abstract C1 WESTERN ILLINOIS UNIV,MACOMB,IL 61455. USA,HUMAN ENGN LAB,WASHINGTON,DC 20310. UNIV MARYLAND,COLL PK,MD 20742. NR 0 TC 0 Z9 0 U1 0 U2 0 PU PSYCHONOMIC SOC INC PI AUSTIN PA 1710 FORTVIEW RD, AUSTIN, TX 78704 SN 0090-5054 J9 B PSYCHONOMIC SOC PD NOV PY 1992 VL 30 IS 6 BP 455 EP 455 PG 1 WC Psychology, Mathematical SC Psychology GA JV167 UT WOS:A1992JV16700190 ER PT J AU GALBICKA, G KAUTZ, M JAGERS, T AF GALBICKA, G KAUTZ, M JAGERS, T TI RESPONSE NUMBER AND TARGETED PERCENTILE SCHEDULES - MANIPULATING TARGET RUN LENGTH SO BULLETIN OF THE PSYCHONOMIC SOCIETY LA English DT Meeting Abstract C1 WALTER REED ARMY INST RES,DEPT MED NEUROSCI,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU PSYCHONOMIC SOC INC PI AUSTIN PA 1710 FORTVIEW RD, AUSTIN, TX 78704 SN 0090-5054 J9 B PSYCHONOMIC SOC PD NOV PY 1992 VL 30 IS 6 BP 476 EP 476 PG 1 WC Psychology, Mathematical SC Psychology GA JV167 UT WOS:A1992JV16700411 ER PT J AU WHITLOCK, MWL DIETRICH, RA STEIMKE, EH TENHOLDER, MF AF WHITLOCK, MWL DIETRICH, RA STEIMKE, EH TENHOLDER, MF TI RHODOTORULA-RUBRA CONTAMINATION IN FIBEROPTIC BRONCHOSCOPY SO CHEST LA English DT Article AB Rhodotorula rubra was recovered in 18 bronchoscopic specimens from 15 patients from May to November 1987. One hundred and twenty-one bronchoscopies were performed during that period by two bronchoscopists (W. W.; R.D.) at Letterman Army Medical Center in San Francisco. Isolation of R rubra occurred in 11 bronchoalveolar lavage (BAL) specimens, four bronchial washes, and three transbronchial biopsies. Clinical infection was not present in any of these patients, although five were immunocompromised hosts. After a stepwise infection control review of the laboratory, the bronchoscopy suite, bronchoscopists, and the fiberoptic bronchoscope failed to recover the organism, a systematic evaluation of the cleaning procedure was undertaken. We discovered that replacement of the suction valve and the rubber biopsy valve on the biopsy channel immediately after cleaning allowed moisture to accumulate in these areas. Removal of both the suction valve and biopsy valve during periods of nonuse resulted in adequate drying of the biopsy channel and eradication of contamination from December 1987 to May 1990 (350 bronchoscopies). Epidemiologic and infection control surveillance is critical for bronchoscopy, especially when possible pathogens are recovered by BAL in the immunocompromised patient. C1 EISENHOWER ARMY MED CTR, INTENS CARE UNIT, FT GORDON, GA USA. MED COLL GEORGIA, MED, AUGUSTA, GA 30912 USA. RP WHITLOCK, MWL (reprint author), VET AFFAIRS MED CTR, PULM DIS SECT, AUGUSTA, GA 30910 USA. NR 12 TC 13 Z9 13 U1 0 U2 0 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 USA SN 0012-3692 J9 CHEST JI Chest PD NOV PY 1992 VL 102 IS 5 BP 1516 EP 1519 PG 4 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA JX209 UT WOS:A1992JX20900042 ER PT J AU TAYLOR, AJ ROGAN, KM GAITHER, NS HULL, RW EDWARDS, FH AF TAYLOR, AJ ROGAN, KM GAITHER, NS HULL, RW EDWARDS, FH TI TRAUMATIC CORONARY ARTERY-ATRIOVENTRICULAR FISTULA - A 26-YEAR FOLLOW-UP WITH APPLICATION OF TRANSESOPHAGEAL ECHOCARDIOGRAPHY SO CHEST LA English DT Letter RP TAYLOR, AJ (reprint author), WALTER REED ARMY MED CTR,WASHINGTON,DC 20307, USA. NR 2 TC 3 Z9 3 U1 0 U2 0 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 SN 0012-3692 J9 CHEST JI Chest PD NOV PY 1992 VL 102 IS 5 BP 1632 EP 1632 PG 1 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA JX209 UT WOS:A1992JX20900087 PM 1424917 ER PT J AU ANDERS, GT JOHNSON, JE AF ANDERS, GT JOHNSON, JE TI BRONCHOSCOPY IN NORTH-AMERICA - THE ACCP SURVEY SO CHEST LA English DT Letter ID TRANS-BRONCHIAL BIOPSY; FLUOROSCOPY RP ANDERS, GT (reprint author), BROOKE ARMY MED CTR,PULM DIS CRIT CARE SERV,FT SAM HOUSTON,TX 78234, USA. NR 5 TC 0 Z9 0 U1 0 U2 0 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 SN 0012-3692 J9 CHEST JI Chest PD NOV PY 1992 VL 102 IS 5 BP 1638 EP 1638 DI 10.1378/chest.102.5.1638-b PG 1 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA JX209 UT WOS:A1992JX20900101 PM 1424925 ER PT J AU INOUYE, RR JACOBAZZI, JD AF INOUYE, RR JACOBAZZI, JD TI THE GREAT CHICAGO FLOOD OF 1992 SO CIVIL ENGINEERING LA English DT Article AB April 13, 1992, 5:57 a.m. The boiler room engineer at Chicago's Merchandise Mart called the city's fire department to report water rushing into the building's third basement. This was the beginning of the Great Chicago Flood of 1992. Here's the story of 74 days of extraordinary disaster response by engineers, contractors, and city, state and federal officials. RP INOUYE, RR (reprint author), USA,CORPS ENGINEERS,CHICAGO,IL, USA. NR 0 TC 4 Z9 4 U1 0 U2 1 PU ASCE-AMER SOC CIVIL ENGINEERS PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0885-7024 J9 CIVIL ENG JI Civil Eng. PD NOV PY 1992 VL 62 IS 11 BP 52 EP 55 PG 4 WC Engineering, Civil SC Engineering GA JV102 UT WOS:A1992JV10200012 ER PT J AU LECKIE, RG BUCKNER, AB BORNEMANN, M AF LECKIE, RG BUCKNER, AB BORNEMANN, M TI SEAT BELT-RELATED THYROIDITIS DOCUMENTED WITH THYROID TC-99M PERTECHNETATE SCANS SO CLINICAL NUCLEAR MEDICINE LA English DT Article AB A 64-year-old man presented with clinical unilateral thyroiditis after chronic left neck trauma from his car seat belt. Thyroid function tests were normal. The initial thyroid Tc-99m pertechnetate scan demonstrated decreased uptake in the entire left lobe of the thyroid. The follow-up scan 1 month later showed a more normal uptake in the left lobe. This patient's clinical course, laboratory values, and nuclear medicine scans are compatible with thyroiditis secondary to trauma sustained from his seat belt. C1 TRIPLER ARMY MED CTR,DEPT RADIOL,HONOLULU,HI 96859. TRIPLER ARMY MED CTR,DEPT NUCL MED,HONOLULU,HI 96859. TRIPLER ARMY MED CTR,DEPT ENDOCRINOL,HONOLULU,HI 96859. NR 6 TC 5 Z9 5 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0363-9762 J9 CLIN NUCL MED JI Clin. Nucl. Med. PD NOV PY 1992 VL 17 IS 11 BP 859 EP 860 DI 10.1097/00003072-199211000-00003 PG 2 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA JX524 UT WOS:A1992JX52400003 PM 1330393 ER PT J AU SHANLEY, DJ AUBER, AE WATABE, JT BUCKNER, AB AF SHANLEY, DJ AUBER, AE WATABE, JT BUCKNER, AB TI PIGMENTED VILLONDULAR SYNOVITIS OF THE KNEE DEMONSTRATED ON BONE-SCAN - CORRELATION WITH US, CT, AND MRI SO CLINICAL NUCLEAR MEDICINE LA English DT Note ID VILLONODULAR SYNOVITIS C1 TRIPLER ARMY MED CTR,DEPT NUCL MED,HONOLULU,HI 96859. RP SHANLEY, DJ (reprint author), TRIPLER ARMY MED CTR,DEPT RADIOL,HONOLULU,HI 96859, USA. NR 3 TC 4 Z9 4 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0363-9762 J9 CLIN NUCL MED JI Clin. Nucl. Med. PD NOV PY 1992 VL 17 IS 11 BP 901 EP 902 DI 10.1097/00003072-199211000-00017 PG 2 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA JX524 UT WOS:A1992JX52400017 PM 1424384 ER PT J AU STOFFEY, RD LECKIE, RG BUCKNER, AB AF STOFFEY, RD LECKIE, RG BUCKNER, AB TI INCIDENTAL FINDING OF PULMONARY SARCOIDOSIS DURING STRESS THALLIUM IMAGING SO CLINICAL NUCLEAR MEDICINE LA English DT Note ID MYOCARDIAL SARCOIDOSIS; GA-67; TL-201 C1 TRIPLER ARMY MED CTR,DEPT RADIOL,HONOLULU,HI 96859. TRIPLER ARMY MED CTR,DEPT NUCL MED,HONOLULU,HI 96859. NR 7 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0363-9762 J9 CLIN NUCL MED JI Clin. Nucl. Med. PD NOV PY 1992 VL 17 IS 11 BP 910 EP 912 DI 10.1097/00003072-199211000-00022 PG 3 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA JX524 UT WOS:A1992JX52400022 PM 1424389 ER PT J AU GLIGIC, A STOJANOVIC, R OBRADOVIC, M HLACA, D DIMKOVIC, N DIGLISIC, G LUKAC, V LER, Z BOGDANOVIC, R ANTONIJEVIC, B ROPAC, D AVSICZUPANC, T LEDUC, JW KSIAZEK, T YANAGIHARA, R GAJDUSEK, DC AF GLIGIC, A STOJANOVIC, R OBRADOVIC, M HLACA, D DIMKOVIC, N DIGLISIC, G LUKAC, V LER, Z BOGDANOVIC, R ANTONIJEVIC, B ROPAC, D AVSICZUPANC, T LEDUC, JW KSIAZEK, T YANAGIHARA, R GAJDUSEK, DC TI HEMORRHAGIC-FEVER WITH RENAL SYNDROME IN YUGOSLAVIA - EPIDEMIOLOGIC AND EPIZOOTIOLOGIC FEATURES OF A NATIONWIDE OUTBREAK IN 1989 SO EUROPEAN JOURNAL OF EPIDEMIOLOGY LA English DT Article DE HEMORRHAGIC FEVER; HANTAVIRUS; BUNYAVIRIDAE; RODENTS AB A nationwide epidemic of hemorrhagic fever with renal syndrome (HFRS) occurred in Yugoslavia in 1989. Sera from 609 hospitalized patients, from all six Republics (Bosnia and Hercegovina, Croatia, Macedonia, Montenegro Serbia, Slovenia) and two Provinces (Kosovo and Vojvodina), who had signs and symptoms suggestive of HFRS, and sera and lung tissues from 544 small mammals belonging to 13 species were studied for evidence of hantavirus infection. Of the 226 patients with serologically confirmed HFRS, 182 resided in Bosnia and Hercegovina or in Serbia. The severity of disease differed from region to region, with an overall fatality of 6.6% (15/226). Patients from southern Yugoslavia tended to have more severe disease and exhibited two types of antibody patterns, while approximately equal numbers of clinically severe and mild cases of HFRS were registered in central Yugoslavia, where four types of antibody patterns were found. Two of these antibody patterns suggested the existence of hantaviruses which are antigenically distinct from those reported to date. Two seasonal peaks of disease, one during the summer and the other in late autumn, were found. Hantaviral antibodies and/or antigens were detected most often in the yellow-necked mouse (Apodemus flavicollis) (88/189), the wood mouse (Apodemus sylvaticus) (28/146), the striped field mouse (Apodemus agrarius) (10/64), the bank vole (Clethrionomys glareolus) (36/63), the house mouse (Mus musculus) (14/29), and the Norway rat (Rattus norvegicus) (14/21). Five other species of rodents and insectivores were infrequently infected. C1 MIL MED ACAD,YU-11000 BELGRADE,YUGOSLAVIA. MED UNIV SARAJEVO,SARAJEVO,BOSNIA & HERCEG. INST RENAL DIS,YU-11000 BELGRADE,YUGOSLAVIA. INST INFECT & TROP DIS,YU-11000 BELGRADE,YUGOSLAVIA. MIL HOSP INFECT DIS,ZAGREB,CROATIA. MED UNIV LJUBLJANA,LJUBLJANA,BOSNIA & HERCEG. USA,MED RES INST INFECT DIS,DIV DIS ASSESSMENT,FREDERICK,MD 21701. NINCDS,CENT NERVOUS SYST STUDIES LAB,BETHESDA,MD 20892. INST MOTHER & CHILD HLTH,YU-11000 BELGRADE,YUGOSLAVIA. RP GLIGIC, A (reprint author), INST IMMUNOL & VIROL,VOJVODE STEPE 458,YU-11000 BELGRADE,YUGOSLAVIA. NR 0 TC 37 Z9 37 U1 0 U2 3 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 0393-2990 J9 EUR J EPIDEMIOL JI Eur. J. Epidemiol. PD NOV PY 1992 VL 8 IS 6 BP 816 EP 825 DI 10.1007/BF00145326 PG 10 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA KU826 UT WOS:A1992KU82600010 PM 1363468 ER PT J AU KADAKIA, SC AF KADAKIA, SC TI THE DISAPPEARING COLONIC IRRIGATION TUBE SO GASTROINTESTINAL ENDOSCOPY LA English DT Letter ID FOREIGN-BODIES RP KADAKIA, SC (reprint author), BROOKE ARMY MED CTR,DEPT MED,GASTROENTEROL SERV,SAN ANTONIO,TX 78234, USA. NR 6 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0016-5107 J9 GASTROINTEST ENDOSC JI Gastrointest. Endosc. PD NOV-DEC PY 1992 VL 38 IS 6 BP 733 EP 734 DI 10.1016/S0016-5107(92)70589-6 PG 2 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA KE058 UT WOS:A1992KE05800032 PM 1473692 ER PT J AU TORRIERI, D AF TORRIERI, D TI ALGORITHMS FOR FINDING AN OPTIMAL SET OF SHORT DISJOINT PATHS IN A COMMUNICATION-NETWORK SO IEEE TRANSACTIONS ON COMMUNICATIONS LA English DT Article AB The motives for seeking a set of short disjoint paths in a communication network are explained. A sequentially constructed optimal set is defined. Three efficient algorithms, one that constructs an optimal set and two that construct approximations, are presented. One of the latter algorithms not only constructs a larger set of short disjoint paths than an iterated version of the standard Dijkstra algorithm, but also offers a major reduction in computation time for large networks. RP TORRIERI, D (reprint author), USA,SURVIVABIL MANAGEMENT OFF,ADELPHI,MD 20783, USA. NR 7 TC 23 Z9 23 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0090-6778 J9 IEEE T COMMUN JI IEEE Trans. Commun. PD NOV PY 1992 VL 40 IS 11 BP 1698 EP 1702 DI 10.1109/26.179933 PG 5 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA KE115 UT WOS:A1992KE11500007 ER PT J AU UDOMSANGPETCH, R WEBSTER, HK PATTANAPANYASAT, K PITCHAYANGKUL, S THAITHONG, S AF UDOMSANGPETCH, R WEBSTER, HK PATTANAPANYASAT, K PITCHAYANGKUL, S THAITHONG, S TI CYTOADHERENCE CHARACTERISTICS OF ROSETTE-FORMING PLASMODIUM-FALCIPARUM SO INFECTION AND IMMUNITY LA English DT Article ID HUMAN CEREBRAL MALARIA; HUMAN-ENDOTHELIAL CELLS; INFECTED ERYTHROCYTES; PARASITIZED ERYTHROCYTES; MEDIATES CYTOADHERENCE; MEMBRANE GLYCOPROTEIN; VASCULAR ENDOTHELIUM; FLOW CONDITIONS; MELANOMA-CELLS; OKM5 ANTIGEN AB Sequestration of Plasmodium falciparum-infected erythrocytes to the capillary endothelium can cause obstruction and localized tissue damage. Occlusion of vessels in falciparum malaria infection has been related to two properties of the parasite: adhesion to endothelial cells and rosette formation. Our study on P. falciparum isolates from Thailand producing variable numbers of rosettes suggests the involvement of rosettes in capillary blockage caused by direct adhesion of the rosette-forming infected erythrocytes to various target cells, e.g., live human umbilical vein endothelial cells, monocytes, and platelets. These rosettes did not bind Formalin-fixed target cells, nor did they bind to live or fixed C32 or G361 melanoma cells. Classification of the receptors involved in cytoadherence of endothelial cells and monocytes by specific antibody blocking and flow cytometry indicated that CD36 was involved in the adherence of monocytes but that other receptors besides CD36 may be involved in parasite adherence to endothelial cells. The cytoadherence of infected erythrocytes to monocytes was also associated with CD54 (ICAM-1). Further, differentiation of adherent monocytes resulted in an inversion of CD36 and CD54 levels on the cell surface which correlated with a decrease in surface binding of infected erythrocytes. This observation suggests that the state of cell activation and differentiation may also contribute to sequestration of parasites and to the pathogenesis of malaria. C1 MAHIDOL UNIV,FAC GRAD STUDIES,DIV HEMATOL,BANGKOK 10700,THAILAND. ARMED FORCES RES INST MED SCI,DEPT IMMUNOL & BIOCHEM,USA MED COMPONENT,BANGKOK,THAILAND. CHULALONGKORN HOSP,FAC SCI,DEPT BIOL,BANGKOK,THAILAND. RP UDOMSANGPETCH, R (reprint author), MAHIDOL UNIV,FAC SCI,DEPT PATHOBIOL,BANGKOK 10700,THAILAND. NR 29 TC 25 Z9 25 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD NOV PY 1992 VL 60 IS 11 BP 4483 EP 4490 PG 8 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA JV763 UT WOS:A1992JV76300006 PM 1383150 ER PT J AU ELKINS, KL LEIBY, DA WINEGAR, RK NACY, CA FORTIER, AH AF ELKINS, KL LEIBY, DA WINEGAR, RK NACY, CA FORTIER, AH TI RAPID GENERATION OF SPECIFIC PROTECTIVE IMMUNITY TO FRANCISELLA-TULARENSIS SO INFECTION AND IMMUNITY LA English DT Article ID SALMONELLA-TYPHIMURIUM INFECTION; TUMOR-NECROSIS-FACTOR; NATURAL-KILLER-CELLS; LISTERIA-MONOCYTOGENES; T-CELLS; ANTIBACTERIAL ACTIVITY; INTERFERON-GAMMA; LYMPHOCYTES-T; FACTOR-ALPHA; MICE AB Mice inoculated either subcutaneously (s.c.) or intradermally (i.d.) with a sublethal dose of Francisella tularensis LVS are immune to a lethal intraperitoneal (i.p.) or intravenous (i.v.) challenge of LVS. Here, we show that this immunity developed quite rapidly: mice given a sublethal dose of live LVS s.c. or i.d. (but not i.v.) withstood lethal i.p., i.v., or i.d. challenge as early as 2 days after the initial inoculation, despite the presence of bacterial burdens already in tissues. The magnitude of this early protection was quite impressive. The i.p. 50% lethal dose (LD50) in naive C3H/HeN mice was only 2 bacteria, while the i.p. LD50 in mice given 10(4) LVS i.d. 3 days previously was 3 x 10(6) bacteria. Similarly, the i.v. LD50 in C3H/HeN mice shifted from 3 x 10(2) in naive mice to 5 x 10(6) in primed mice within 3 days after i.d. LVS infection. Comparable changes in the i.p. and i.v. LD50 were observed in C57BL/6J mice. This rapid generation of protective immunity was specific for LVS, in that mice given a sublethal i.d. inoculation of LVS did not survive a lethal challenge with either Salmonella typhimurium W118 or Escherichia coli 0118 BORT at any time, nor could mice given sublethal doses of S. typhimurium, E. coli, or Mycobacterium bovis BCG survive lethal doses of LVS. Although an increase in the mean time to death from S. typhimurium infection was noted when mice were given a sublethal i.d. dose of LVS 4 to 14 days earlier, no overall increase in protection or change in the S. typhimurium LD50 was observed. Thus, sublethal infection with LVS at skin sites induced rapid and specific protective immunity. RP ELKINS, KL (reprint author), WALTER REED ARMY INST RES,DEPT CELLULAR IMMUNOL,9620 MED CTR DR,SUITE 200,ROCKVILLE,MD 20850, USA. NR 47 TC 37 Z9 37 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD NOV PY 1992 VL 60 IS 11 BP 4571 EP 4577 PG 7 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA JV763 UT WOS:A1992JV76300018 PM 1398969 ER PT J AU SCHNEIDER, DA MCGUIGGIN, ME KAMIMORI, GH AF SCHNEIDER, DA MCGUIGGIN, ME KAMIMORI, GH TI A COMPARISON OF THE BLOOD LACTATE AND PLASMA-CATECHOLAMINE THRESHOLDS IN UNTRAINED MALE-SUBJECTS SO INTERNATIONAL JOURNAL OF SPORTS MEDICINE LA English DT Article DE EPINEPHRINE; NOREPINEPHRINE; CATECHOLAMINES; LACTATE THRESHOLD ID ANAEROBIC THRESHOLD; PROGRESSIVE EXERCISE; INCREMENTAL EXERCISE; GRADED-EXERCISE; FUTURE-RESEARCH; MUSCLE; GLYCOGENOLYSIS; DIRECTIONS; BLOCKADE; OUTPUT AB The relationships between the plasma epinephrine threshold (TE), the norepinephrine threshold (TNE), and the blood lactate threshold (Tlact) were examined during incremental cycling in 10 untrained male subjects. When oxygen uptake (VO2) measured at each threshold was expressed as a percent of VO2max, the thresholds occurred at 40.8 +/- 2.4%, 45.5 +/- 3.0%, and 46.6 +/- 3.0% for Tlact, TE, and TNE, respectively. The average VO2 and power output values obtained at the lactate and epinephrine thresholds were not found to be significantly different (p < 0.10). However, Tlact and TE occurred simultaneously in six subjects, whereas TE occurred at a higher work stage than Tlact in the other four subjects. The mean VO2 and power output values determined at TNE were found to be significantly greater than the values obtained at Tlact (p < 0.05). These two thresholds occurred together in four subjects, while TNE was observed to occur at a higher work stage than Tlact in the other six subjects. None of the differences between TE and TNE were significantly different. Although plasma norepinephrine concentrations were much greater than those for epinephrine at a given power output, the two catecholamine thresholds occurred simultaneously in seven subjects. The results are not consistent with the hypothesis that the increase in plasma catecholamine levels during incremental exercise is the sole determinant of the lactate threshold. It is also possible that a decrease in muscle pH, due to increased lactic acid, stimulated a reflex increase in sympathetic outflow and a subsequent rise in catecholamine levels. C1 WALTER REED ARMY INST RES,DEPT BEHAV BIOL,WASHINGTON,DC 20307. RP SCHNEIDER, DA (reprint author), NORTHEASTERN UNIV,DEPT CARDIOPULM SCI,HUMAN PERFORMANCE LAB,120 DOCKSER HALL,BOSTON,MA 02115, USA. NR 28 TC 36 Z9 36 U1 1 U2 8 PU GEORG THIEME VERLAG PI STUTTGART PA P O BOX 30 11 20, D-70451 STUTTGART, GERMANY SN 0172-4622 J9 INT J SPORTS MED JI Int. J. Sports Med. PD NOV PY 1992 VL 13 IS 8 BP 562 EP 566 DI 10.1055/s-2007-1024565 PG 5 WC Sport Sciences SC Sport Sciences GA KE732 UT WOS:A1992KE73200003 PM 1487337 ER PT J AU SMITH, PB SNYDER, AP AF SMITH, PB SNYDER, AP TI CHARACTERIZATION OF BACTERIA BY QUARTZ TUBE PYROLYSIS-GAS CHROMATOGRAPHY ION TRAP MASS-SPECTROMETRY SO JOURNAL OF ANALYTICAL AND APPLIED PYROLYSIS LA English DT Article DE BACTERIA; GAS CHROMATOGRAPHY; ION TRAP MASS SPECTROMETRY; QUARTZ TUBE PYROLYSIS; PYROLYSIS ID CELLULAR FATTY-ACIDS; LIQUID-CHROMATOGRAPHY; CHEMICAL MARKER; MULTIVARIATE ANALYSES; MAMMALIAN-TISSUES; IDENTIFICATION; DIFFERENTIATION; CLASSIFICATION; CELLS; MICROORGANISMS AB Ten bacterial strains were analyzed using a quartz tube pyrolysis-gas chromatography/ion trap mass spectrometry (Py-GC/MS) system. Microgram amounts of bacteria were introduced directly into the instrument using a commercially available pyrolysis unit. The pyrolysis tube was heated to 1000-degrees-C in an inert helium atmosphere, and the thermally induced degradation products were separated on a short capillary column with detection by an ion trap mass spectrometer. The total analysis time, including sample preparation and introduction, was under 10 min. Bacteria were differentiated by a visual comparison of pyrolytic patterns of their lipid components in their total ion chromatograms. Additional information was provided by the various analytical dimensions in the GC and MS domains. By comparison with fatty acid methyl ester analysis and other chemotaxonomic-based differentiation schemes, this technique should be widely applicable to the detection and identification of most microorganisms. C1 USA,CTR CHEM RES DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010. RP SMITH, PB (reprint author), GEOCENTERS INC,GUNPOWDER BRANCH,POB 68,ABERDEEN PROVING GROUND,MD 21010, USA. NR 32 TC 11 Z9 11 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-2370 J9 J ANAL APPL PYROL JI J. Anal. Appl. Pyrolysis PD NOV PY 1992 VL 24 IS 1 BP 23 EP 38 DI 10.1016/0165-2370(92)80002-4 PG 16 WC Chemistry, Analytical; Spectroscopy SC Chemistry; Spectroscopy GA KD094 UT WOS:A1992KD09400002 ER PT J AU PLATOFF, GE HILL, DW KOCH, TR CAPLAN, YH AF PLATOFF, GE HILL, DW KOCH, TR CAPLAN, YH TI SERIAL CAPILLARY GAS-CHROMATOGRAPHY FOURIER-TRANSFORM INFRARED SPECTROMETRY MASS-SPECTROMETRY (GC/IR/MS) - QUALITATIVE AND QUANTITATIVE-ANALYSIS OF AMPHETAMINE, METHAMPHETAMINE, AND RELATED ANALOGS IN HUMAN URINE SO JOURNAL OF ANALYTICAL TOXICOLOGY LA English DT Article C1 MARYLAND MED LAB INC,BALTIMORE,MD 21227. NATL CTR FORENS SCI,BALTIMORE,MD 21227. RP PLATOFF, GE (reprint author), USA,FORENS TOX DRUG TEST LAB,FT GEORGE G MEADE,MD 20755, USA. NR 20 TC 11 Z9 11 U1 1 U2 3 PU PRESTON PUBLICATIONS INC PI NILES PA 7800 MERRIMAC AVE PO BOX 48312, NILES, IL 60648 SN 0146-4760 J9 J ANAL TOXICOL JI J. Anal. Toxicol. PD NOV-DEC PY 1992 VL 16 IS 6 BP 389 EP 397 PG 9 WC Chemistry, Analytical; Toxicology SC Chemistry; Toxicology GA JZ331 UT WOS:A1992JZ33100010 PM 1293407 ER PT J AU ANDREAS, EL AF ANDREAS, EL TI UNCERTAINTY IN A PATH-AVERAGED MEASUREMENT OF THE FRICTION VELOCITY-U-ASTERISK SO JOURNAL OF APPLIED METEOROLOGY LA English DT Article ID ATMOSPHERIC SURFACE LAYER; TURBULENT KINETIC-ENERGY; INNER SCALE; OPTICAL-SCINTILLATION; FLUXES; DISSIPATION; SPECTRUM; HEAT; PARAMETERS; OCEAN AB Several electro-optical methods exist for measuring a path-averaged value of the inner scale of turbulence l0. By virtue of Monin-Obukhov similarity, in the atmospheric surface layer such l0 measurements are related to the friction velocity u* or to the surface stress tau = rhou*2 , where rho is the air density. Because l0 is a path-averaged quantity, u* is too. Here the question of how precisely u* can be measured is investigated by combining these inner-scale measurements with two-wavelength scintillation measurements that yield the sensible and latent heat fluxes and, thereby, facilitate stability corrections. The analysis suggests that current path-averaging instruments can generally measure u* to +/-20%-30%. RP ANDREAS, EL (reprint author), USA,COLD REG RES & ENGN LAB,CORPS ENGINEERS,72 LYME RD,HANOVER,NH 03755, USA. NR 39 TC 12 Z9 12 U1 1 U2 3 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 SN 0894-8763 J9 J APPL METEOROL JI J. Appl. Meteorol. PD NOV PY 1992 VL 31 IS 11 BP 1312 EP 1321 DI 10.1175/1520-0450(1992)031<1312:UIAPAM>2.0.CO;2 PG 10 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA JV728 UT WOS:A1992JV72800006 ER PT J AU MILLER, MS AF MILLER, MS TI STEP-FUNCTION CURRENT IN A METALLIC FOIL AS A STEP-FUNCTION HEAT-FLUX SOURCE SO JOURNAL OF APPLIED PHYSICS LA English DT Article AB An exact solution is derived to the one-dimensional, time-dependent, heat-conduction equation for a two-layer, semi-infinite, composite solid with uniform heat generation in the surface layer, no heat transfer through the surface plane, and uniform initial temperature. The interface between the two layers is assumed to have no thermal contact resistance. This solution enables a discussion of the ideality with which a step-function electric current in a metallic foil can generate a step-function heat flux into a contacting semi-infinite solid. Previous measurements of thermal diffusivity (based on the above conditions) have relied on the idealized constant-flux solution for data reduction. It is shown here that the temperature errors in the substrate arising from nonideality of the constant-flux boundary condition increase with depth into the substrate, foil thickness, and decreasing thermal conductivity/diffusivity of the substrate. RP MILLER, MS (reprint author), USA,BALLIST RES LABS,ABERDEEN PROVING GROUND,MD 21005, USA. NR 5 TC 3 Z9 3 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD NOV 1 PY 1992 VL 72 IS 9 BP 3904 EP 3907 DI 10.1063/1.352266 PG 4 WC Physics, Applied SC Physics GA JW937 UT WOS:A1992JW93700008 ER PT J AU SINGH, VP XU, Q MCCLURE, JC MORTON, DC AF SINGH, VP XU, Q MCCLURE, JC MORTON, DC TI PHOSPHOR CURRENTS IN ZNSMN AC THIN-FILM ELECTROLUMINESCENT DISPLAY DEVICES SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID HIGH-FIELD; SIMPLE-MODEL; TRANSPORT AB Conduction current in the phosphor layer of ZnS:Mn ac thin film electroluminescent (ACTFEL) display device was measured as a function of the amplitude and the rise time of the bipolar voltage pulses: electric field in the phosphor was also determined. It was found that the clamping field of an ac thin film electroluminescent device is not a single-valued device characteristic. The clamping field depended upon the rise time of the applied voltage pulse increasing in value as the rise time became smaller. These data were interpreted in terms of a nonideal breakdown of the insulator-phosphor interface and a time delay involved in the emission of electrons from this interface. To account for the nonideality in the interface breakdown the ac equivalent circuit of the ACTFEL device was modified by including a voltage-dependent resistor in parallel with the phosphor capacitance. The phosphor current measurements, transferred charge measurements and tunneling current calculations indicate that in the nonhysteretic ZnS:Mn devices under investigation, impact ionization in the phosphor layer, if present at all, leads to relatively small carrier multiplication factors. C1 UNIV TEXAS,DEPT MET & MAT ENGN,EL PASO,TX 79968. USA,LABCOM,ELECTR TECHNOL & DEVICES LAB,FT MONMOUTH,NJ 07703. RP SINGH, VP (reprint author), UNIV TEXAS,DEPT ELECT ENGN,EL PASO,TX 79968, USA. NR 24 TC 11 Z9 11 U1 0 U2 2 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD NOV 1 PY 1992 VL 72 IS 9 BP 4148 EP 4155 DI 10.1063/1.352223 PG 8 WC Physics, Applied SC Physics GA JW937 UT WOS:A1992JW93700042 ER PT J AU KUDRYK, VL SCHEIDT, MJ MCQUADE, MJ SUTHERLAND, DE VANDYKE, TE HOLLINGER, JO AF KUDRYK, VL SCHEIDT, MJ MCQUADE, MJ SUTHERLAND, DE VANDYKE, TE HOLLINGER, JO TI TOXIC EFFECT OF ETHYLENE-OXIDE-STERILIZED FREEZE-DRIED BONE ALLOGRAFT ON HUMAN GINGIVAL FIBROBLASTS SO JOURNAL OF BIOMEDICAL MATERIALS RESEARCH LA English DT Article ID PERIODONTAL OSSEOUS DEFECTS; CLINICAL EVALUATION; DIALYSIS PATIENTS; IGE ANTIBODIES; GAS; EXPOSURE; INVITRO; RATS; CHROMATOGRAPHY; LYMPHOCYTES AB Freeze-dried bone allograft (FDBA) which either had or had not been sterilized by exposure to ethylene oxide (EtO) prior to lyophilization was obtained from two commercial sources. EtO-sterilized FDBA was reexposed to EtO as a positive control. Gas chromatograph assays revealed that three out of four commercially obtained EtO sterilized FDBA had no detectable EtO, with one sample having 0.21 parts per million (PPM). Surprisingly, 0.24 PPM was detected in one sample which had not been sterilized with EtO gas. This was presumed due to contamination from a gas-sterilized rubber stopper. In the cell toxicity study, FDBA and human gingival fibroblasts (HGF) were added simultaneously, incubated for 72 h, and fixed and stained. Samples of FDBA sterilized with EtO which were free of EtO did not alter HGF growth. However, the positive control FDBA which contained 0.72 PPM EtO had a deleterious effect on HGF. FDBA with EtO residuals caused morphologic change in HGF. C1 USA,DENT ACTIV,BERLIN,GERMANY. BAYLOR COLL DENT,DEPT PERIODONTOL,DALLAS,TX 75246. USA,FT GORDON,GA 30905. EASTMAN DENT CTR,DEPT PERIODONTOL,ROCHESTER,NY 14620. WALTER REED ARMY MED CTR,IDR,WASHINGTON,DC 20307. RP KUDRYK, VL (reprint author), USA,DENT ACTIV,FT BLISS,TX, USA. NR 39 TC 12 Z9 12 U1 0 U2 1 PU JOHN WILEY & SONS INC PI NEW YORK PA 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0021-9304 J9 J BIOMED MATER RES JI J. Biomed. Mater. Res. PD NOV PY 1992 VL 26 IS 11 BP 1477 EP 1488 DI 10.1002/jbm.820261107 PG 12 WC Engineering, Biomedical; Materials Science, Biomaterials SC Engineering; Materials Science GA JU766 UT WOS:A1992JU76600006 PM 1447230 ER PT J AU CRAMER, CJ TRUHLAR, DG AF CRAMER, CJ TRUHLAR, DG TI PM3-SM3 - A GENERAL PARAMETERIZATION FOR INCLUDING AQUEOUS SOLVATION EFFECTS IN THE PM3 MOLECULAR-ORBITAL MODEL SO JOURNAL OF COMPUTATIONAL CHEMISTRY LA English DT Article ID CHARGE MODEL; SEMIEMPIRICAL METHODS; SOLVENT; OPTIMIZATION; SURFACE; WATER; AM1 AB Our recently proposed scheme for including aqueous solvation free energies in parameterized NDDO SCF models is extended to the Parameterized Model 3 semiempirical Hamiltonian. The solvation model takes accurate account of the hydrophobic effect for hydrocarbons, as well as electric polarization of the solvent, the free energy of cavitation, and dispersion interactions. Eight heteroatoms are included (along with H and C), and the new model is parameterized accurately for the water molecule itself, which allows meaningful treatments of specifically hydrogen bonded water molecules. The unphysical partial charges on nitrogen atoms predicted by the Parameterized Model 3 Hamiltonian limit the accuracy of the predicted solvation energies for some compounds containing nitrogen, but the model may be very useful for other systems, especially those for which PM3 is preferred over AM1 for the solute properties of the particular system under study. C1 USA,CTR CHEM RES DEV & ENGN,RES DIRECTORATE,DIV PHYS,ABERDEEN PROVING GROUND,MD 21010. UNIV MINNESOTA,INST SUPERCOMP,DEPT CHEM,MINNEAPOLIS,MN 55455. UNIV MINNESOTA,ARMY HIGH PERFORMANCE COMP RES CTR,MINNEAPOLIS,MN 55455. RI Truhlar, Donald/G-7076-2015; Cramer, Christopher/B-6179-2011 OI Truhlar, Donald/0000-0002-7742-7294; Cramer, Christopher/0000-0001-5048-1859 NR 37 TC 191 Z9 192 U1 0 U2 4 PU JOHN WILEY & SONS INC PI NEW YORK PA 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0192-8651 J9 J COMPUT CHEM JI J. Comput. Chem. PD NOV PY 1992 VL 13 IS 9 BP 1089 EP 1097 DI 10.1002/jcc.540130907 PG 9 WC Chemistry, Multidisciplinary SC Chemistry GA JR882 UT WOS:A1992JR88200006 ER PT J AU BALOTIN, RJ MCADAMS, HP DACHMAN, AH AF BALOTIN, RJ MCADAMS, HP DACHMAN, AH TI CALCIFIED INTRAHEPATIC PORTAL-VEIN THROMBUS - DISTINCTION FROM INTRAHEPATIC CHOLEDOCHOLITHIASIS SO JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY LA English DT Article DE LIVER; DISEASES; THROMBUS; VEINS; PORTAL; COMPUTED TOMOGRAPHY; MAGNETIC RESONANCE IMAGING ID COMPUTED-TOMOGRAPHY; CALCIFICATION AB In a case of calcified intrahepatic portal vein thrombus CT demonstrated a branching calcified intrahepatic mass with peripheral enhancement following dynamic bolus contrast medium administration. The distinction from intrahepatic choledocholithiasis was made with normal cholangiography. Calcified portal vein thrombus should be considered an unusual cause of branching calcified intrahepatic mass on CT. C1 UNIV HLTH SCI,UNIFORMED SERV,DEPT RADIOL & NUCL MED,BETHESDA,MD. RP BALOTIN, RJ (reprint author), WALTER REED ARMY MED CTR,DEPT RADIOL,WASHINGTON,DC 20307, USA. RI McAdams, Holman/N-8218-2015 OI McAdams, Holman/0000-0002-7044-3320 NR 8 TC 4 Z9 4 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0363-8715 J9 J COMPUT ASSIST TOMO JI J. Comput. Assist. Tomogr. PD NOV-DEC PY 1992 VL 16 IS 6 BP 977 EP 979 DI 10.1097/00004728-199211000-00028 PG 3 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA JY187 UT WOS:A1992JY18700028 PM 1430452 ER PT J AU BAUMGARTNER, JC MARTIN, H SABALA, CL STRITTMATTER, EJ WILDEY, WL QUIGLEY, NC AF BAUMGARTNER, JC MARTIN, H SABALA, CL STRITTMATTER, EJ WILDEY, WL QUIGLEY, NC TI HISTOMORPHOMETRIC COMPARISON OF CANALS PREPARED BY 4 TECHNIQUES SO JOURNAL OF ENDODONTICS LA English DT Article ID SIMULATED ROOT CANALS; INSTRUMENTATION; VALIDITY AB Numerous methods of root canal preparation have been recommended and used by clinicians. This study used histomorphometrics to determine the area of root canal preparations using four currently popular techniques. Clinicians that were highly skilled in each technique prepared curved canals in acrylic blocks. Each clinician described this technique and discussed the technique with regard to the use of acrylic blocks as compared with dentin. Analysis of the areas of the root canals after preparation revealed a significant difference among the groups. The mean areas after treatment were stepback technique, 17.33 mm2; Cavi-Endo technique, 15.87 mm2; Canal Master technique, 13.56 mm2; and balanced force technique, 17.31 mm2. Photographs of the blocks used in the study were included for inspection by the reader. C1 UNIV OKLAHOMA,EDMOND,OK. WALTER REED ARMY MED CTR,DENT ACT,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,INST DENT RES,WASHINGTON,DC 20307. RP BAUMGARTNER, JC (reprint author), OREGON HLTH SCI UNIV,SCH DENT,611 SW CAMPUS DR,PORTLAND,OR 97201, USA. NR 11 TC 10 Z9 10 U1 0 U2 2 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0099-2399 J9 J ENDODONT JI J. Endod. PD NOV PY 1992 VL 18 IS 11 BP 530 EP 534 DI 10.1016/S0099-2399(06)81208-2 PG 5 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA KG639 UT WOS:A1992KG63900002 PM 1298788 ER PT J AU STAUNTON, DE OCKENHOUSE, CF SPRINGER, TA AF STAUNTON, DE OCKENHOUSE, CF SPRINGER, TA TI SOLUBLE INTERCELLULAR-ADHESION MOLECULE 1-IMMUNOGLOBULIN-G1 IMMUNOADHESIN MEDIATES PHAGOCYTOSIS OF MALARIA-INFECTED ERYTHROCYTES SO JOURNAL OF EXPERIMENTAL MEDICINE LA English DT Note ID PLASMODIUM-FALCIPARUM; ICAM-1 CD54; RECEPTOR; LFA-1; BINDING; MAC-1; LIGAND AB We describe an immunoadhesin molecule containing intercellular adhesion molecule 1 (ICAM-1) molecularly fused to hinge and C(H)2 and C(H)3 domains of the human immunoglobulin G1 H chain that binds Plasmodium falciparum-infected erythrocytes. This receptor-based immunoadhesin is an effective and specific inhibitor of P. falciparum-infected erythrocyte adhesion to ICAM-1-bearing surfaces, but does not inhibit leukocyte function antigen 1 (LFA-1) interaction with ICAM-1. Furthermore, the immunoadhesin promotes phagocytosis and destruction of parasitized erythrocytes by human monocytes. Each of these modes of action has potential for the therapy of malaria. C1 HARVARD UNIV,SCH MED,DEPT PATHOL,BOSTON,MA 02115. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT MED,WASHINGTON,DC 20307. RP STAUNTON, DE (reprint author), CTR BLOOD RES,EQRF,200 LONGWOOD AVE,BOSTON,MA 02115, USA. NR 22 TC 28 Z9 28 U1 0 U2 0 PU ROCKEFELLER UNIV PRESS PI NEW YORK PA 1114 FIRST AVE, 4TH FL, NEW YORK, NY 10021 SN 0022-1007 J9 J EXP MED JI J. Exp. Med. PD NOV 1 PY 1992 VL 176 IS 5 BP 1471 EP 1476 DI 10.1084/jem.176.5.1471 PG 6 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA JV012 UT WOS:A1992JV01200029 PM 1383388 ER PT J AU HOPKINS, MA SHEN, HH AF HOPKINS, MA SHEN, HH TI A MONTE-CARLO SOLUTION FOR RAPIDLY SHEARING GRANULAR FLOWS BASED ON THE KINETIC-THEORY OF DENSE GASES SO JOURNAL OF FLUID MECHANICS LA English DT Article ID STRESS TENSOR; SMOOTH; MICROSTRUCTURE; PARTICLES; DISKS AB A Monte Carlo simulation is developed for the study of rapidly deforming, steady, simple shear flows of inelastic disks or spheres. The simulation is based on the theoretical framework of the kinetic theory of dense gases. In the simulation, space is discarded in an explicit sense and replaced by an isotropic, homogeneous, and uncorrelated space based on the assumption of a state of simple shear, a uniform concentration field, and molecular chaos. The simulation generates a distribution of particle velocities which corresponds to the parameters of the flow. The velocity distribution is a numerical solution to the Boltzmann equation under these conditions. The Monte Carlo simulation defines the limits to the accuracy of analytical granular flow theories based on the kinetic theory and the assumption of molecular chaos. C1 CLARKSON UNIV,DEPT CIVIL & ENVIRONM ENGN,POTSDAM,NY 13676. RP HOPKINS, MA (reprint author), USA,CORPS ENGINEERS,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 15 TC 39 Z9 40 U1 0 U2 2 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 40 WEST 20TH STREET, NEW YORK, NY 10011-4211 SN 0022-1120 J9 J FLUID MECH JI J. Fluid Mech. PD NOV PY 1992 VL 244 BP 477 EP 491 DI 10.1017/S002211209200315X PG 15 WC Mechanics; Physics, Fluids & Plasmas SC Mechanics; Physics GA JZ760 UT WOS:A1992JZ76000022 ER PT J AU BENDER, E HOGAN, A LEGGETT, D MISKOLCZY, G MACDONALD, S AF BENDER, E HOGAN, A LEGGETT, D MISKOLCZY, G MACDONALD, S TI SURFACE CONTAMINATION BY TNT SO JOURNAL OF FORENSIC SCIENCES LA English DT Note DE FORENSIC SCIENCE; TNT; EXPLOSIVE DETECTION; VAPOR; SORPTION; DESORPTION AB We have performed experiments that indicate TNT contamination is present on surfaces exposed to TNT vapor, and that TNT contamination is transferred rapidly between proximate surfaces. Contaminated surfaces continue to be nearly constant sources of TNT vapor for some time after removal of the primary source. C1 USA,CRREL,HANOVER,NH 03755. THERMEDICS INC,WOBURN,MA. FBI LABS,WASHINGTON,DC. NR 4 TC 20 Z9 20 U1 1 U2 4 PU AMER SOC TESTING MATERIALS PI W CONSHOHOCKEN PA 100 BARR HARBOR DR, W CONSHOHOCKEN, PA 19428-2959 SN 0022-1198 J9 J FORENSIC SCI JI J. Forensic Sci. PD NOV PY 1992 VL 37 IS 6 BP 1673 EP 1678 PG 6 WC Medicine, Legal SC Legal Medicine GA KD642 UT WOS:A1992KD64200027 ER PT J AU BUCKNER, C ROBERTS, CR FOUNG, SKH LIPKA, J REYES, GR HADLOCK, K CHAN, L GONGORABIACHI, A HJELLE, B LAL, RB AF BUCKNER, C ROBERTS, CR FOUNG, SKH LIPKA, J REYES, GR HADLOCK, K CHAN, L GONGORABIACHI, A HJELLE, B LAL, RB TI IMMUNE RESPONSIVENESS TO THE IMMUNODOMINANT RECOMBINANT ENVELOPE EPITOPES OF HUMAN T-LYMPHOTROPIC VIRUS TYPE-1 AND TYPE-2 IN DIVERSE GEOGRAPHIC POPULATIONS SO JOURNAL OF INFECTIOUS DISEASES LA English DT Note ID GP46; IDENTIFICATION; NEUTRALIZATION; VARIABILITY; INFECTION; INDUCTION; ANTIBODY; PEPTIDES AB The heterogeneity of immune responsiveness to the immunodominant epitopes of human T lymphotropic virus (HTLV) types I (MTA-1(162-209)) and II (K-55(162-205)) were determined in natural infections with HTLV-I and -II from diverse geographic areas (n = 285). Of the HTLV-I specimens confirmed by polymerase chain reaction (PCR), all North American (n = 37) and Peruvian (n = 19) specimens reacted with MTA-1. Of HTLV-II specimens confirmed by PCR, 44 (96%) of 46 from North American blood donors, 28 (97%) of 29 from native Americans, and all from intravenous drug users (n = 29) reacted with K-55. Specimens from other geographic areas (Peru, 30; Brazil, 4; Mexico, 10; Italy, 5; Somalia 13; Ethiopia, 17; Japan, 32; and Jamaica, 15) all reacted either with MTA-1 or K-55. By synthetic peptide-based serologic typing, all of these specimens could be typed as HTLV-I or -II. In addition to the direct implications of these findings for diagnostic purposes, these data provide indirect evidence for the conservation of immunodominant HTLV(env) epitopes in diverse geographic populations. C1 CTR DIS CONTROL,NATL CTR INFECT DIS,DIV VIRAL & RICKETTSIAL DIS,ATLANTA,GA 30333. WALTER REED ARMY RES INST,DIV DIAGNOST RETROVIROL,ROCKVILLE,MD. STANFORD UNIV,MED CTR,SCH MED,DEPT PATHOL,STANFORD,CA 94305. GENELABS INC,DEPT MOLEC VIROL,REDWOOD CITY,CA. DIAGNOST BIOTECHNOL,SINGAPORE SCI PK,SINGAPORE,SINGAPORE. CTR INVEST REG,MERIDA,MEXICO. UNIV NEW MEXICO,SCH MED,DEPT PATHOL,ALBUQUERQUE,NM 87131. FU NCI NIH HHS [CA-55480]; NHLBI NIH HHS [HL-33811]; NIDA NIH HHS [DA-06596] NR 17 TC 42 Z9 42 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD NOV PY 1992 VL 166 IS 5 BP 1160 EP 1163 PG 4 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA JV015 UT WOS:A1992JV01500031 PM 1383353 ER PT J AU EDMAN, JD STRICKMAN, D KITTAYAPONG, P SCOTT, TW AF EDMAN, JD STRICKMAN, D KITTAYAPONG, P SCOTT, TW TI FEMALE AEDES-AEGYPTI (DIPTERA, CULICIDAE) IN THAILAND RARELY FEED ON SUGAR SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE AEDES-AEGYPTI; SUGAR FEEDING; MULTIPLE BLOOD FEEDING ID NECTAR; FREQUENCY; MOSQUITOS; RESERVES; BEHAVIOR; HABITS AB Female Aedes aegypti (L.) of two different body sizes and provided with different diets (20% sucrose, water only, or 20% sucrose + human blood) were marked and released together in a rural Thai village. Recaptured marked and unmarked (wild) adults were tested for fructose by the cold-anthrone reaction. Both released and wild females showed a low frequency of sugar feeding in nature; both small-bodied and large-bodied individuals failed to sugar feed significantly. Marked females released with sugar in their crop utilized this energy source over the following 2-3 d but failed to replenish it. In contrast, about one-third of wild, resting males showed evidence of recent sugar feeding. This indicated that the absence of plant sugar in females was not caused by a shortage of nectar sources in this rural domestic environment. Presumably, the nonutilization of plant sugar as an energy source increases the frequency of blood feeding and, therefore, the vectorial capacity of Ae. aegypti. C1 MAHIDOL UNIV,FAC SCI,DEPT BIOL,BANGKOK 10700,THAILAND. UNIV MARYLAND,DEPT ENTOMOL,COLL PK,MD 20742. UNIV MARYLAND,CTR AGR BIOTECHNOL,COLL PK,MD 20742. ARMED FORCES RES INST MED SCI,DEPT MED ENTOMOL,BANGKOK,THAILAND. RP EDMAN, JD (reprint author), UNIV MASSACHUSETTS,DEPT ENTOMOL,AMHERST,MA 01003, USA. NR 19 TC 7 Z9 7 U1 0 U2 5 PU ENTOMOL SOC AMER PI LANHAM PA 9301 ANNAPOLIS RD, LANHAM, MD 20706 SN 0022-2585 J9 J MED ENTOMOL JI J. Med. Entomol. PD NOV PY 1992 VL 29 IS 6 BP 1033 EP 1038 PG 6 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA JW623 UT WOS:A1992JW62300021 ER PT J AU GABRIELSEN, B MONATH, TP HUGGINS, JW KEFAUVER, DF PETTIT, GR GROSZEK, G HOLLINGSHEAD, M KIRSI, JJ SHANNON, WM SCHUBERT, EM DARE, J UGARKAR, B USSERY, MA PHELAN, MJ AF GABRIELSEN, B MONATH, TP HUGGINS, JW KEFAUVER, DF PETTIT, GR GROSZEK, G HOLLINGSHEAD, M KIRSI, JJ SHANNON, WM SCHUBERT, EM DARE, J UGARKAR, B USSERY, MA PHELAN, MJ TI ANTIVIRAL (RNA) ACTIVITY OF SELECTED AMARYLLIDACEAE ISOQUINOLINE CONSTITUENTS AND SYNTHESIS OF RELATED SUBSTANCES SO JOURNAL OF NATURAL PRODUCTS LA English DT Article ID ANTINEOPLASTIC AGENTS; THERAPEUTIC ACTIVITY; RAUSCHER LEUKEMIA; NATURAL-PRODUCTS; ALKALOIDS; RIBAVIRIN; LYCORINE; (+)-LYCORICIDINE; (+/-)-LYCORINE; SELENAZOFURIN AB A series of 23 Amaryllidaceae isoquinoline alkaloids and related synthetic analogues were isolated or synthesized and subsequently evaluated in cell culture against the RNA-containing flaviviruses (Japanese encephalitis, yellow fever, and dengue viruses), bunyaviruses (Punta Toro, sandfly fever, and Rift Valley fever viruses), alphavirus (Venezuelan equine encephalomyelitis virus), lentivirus (human immunodeficiency virus-type 1) and the DNA-containing vaccinia virus. Narciclasine [1], lycoricidine [2], pancratistatin [4], 7-deoxypancratistatin [5], and acetates 6-8, isonarciclasine [13a], cis-dihydronarciclasine [14a], trans-dihydronarciclasine [15a], their 7-deoxy analogues 13b-15b, lycorines 16 and 17, and pretazettine [18] exhibited consistent in vitro activity against all three flaviviruses and against the bunyaviruses, Punta Toro and Rift Valley fever virus. Activity against sandfly fever virus was only observed with 7-deoxy analogues. In most cases, however, selectivity of the active compounds was low, with toxicity in uninfected cells (TC50) occurring at concentrations within 10-fold that of the viral inhibitory concentrations (IC50). No activity was observed against human immunodeficiency virus-type 1, Venezuelan equine encephalomyelitis virus, or vaccinia viruses. Pancratistatin [4] and its 7-deoxy analogue 5 were evaluated in two murine Japanese encephalitis mouse models (differing in viral dose challenge, among other factors). In two experiments (low LD50 viral challenge, variant I), prophylactic administration of 4 at 4 and 6 mg/kg/day (2% EtOH/saline, sc, once daily for 7 days, day -1 to +5) increased survival of Japanese-encephalitis-virus-infected mice to 100% and 90%, respectively. In the same model, prophylactic administration of 5 at 40 mg/kg/day in hydroxypropylcellulose (sc, once daily for 7 days, day -1 to +5) increased survival of Japanese-encephalitis-virus-infected mice to 80%. In a second variant (high LD50 viral challenge), administration of 4 at 6 mg/kg/day (ip, twice daily for 9 days, day -1 to +7) resulted in a 50% survival rate. In all cases, there was no survival in the diluent-treated control mice. Thus, 4 and 5 demonstrated activity in mice infected with Japanese encephalitis virus but only at near toxic concentrations. To our knowledge, however, this represents a rare demonstration of chemotherapeutic efficacy (by a substance other than an interferon inducer) in a Japanese-encephalitis-virus-infected mouse model. C1 USA,MED RES INST INFECT DIS,FT DETRICK,FREDERICK,MD 21702. ARIZONA STATE UNIV,DEPT CHEM,TEMPE,AZ 85287. ARIZONA STATE UNIV,CANC RES INST,TEMPE,AZ 85287. SO RES INST,BIRMINGHAM,AL 35255. PHARMECO LABS,SIMI VALLEY,CA 93065. US FDA,DIV ANTIVIRAL DRUG PROD,ROCKVILLE,MD 20855. NR 56 TC 164 Z9 168 U1 3 U2 13 PU AMER SOC PHARMACOGNOSY PI CINCINNATI PA LLOYD LIBRARY & MUSEUM 917 PLUM ST, CINCINNATI, OH 45202 SN 0163-3864 J9 J NAT PROD JI J. Nat. Prod. PD NOV PY 1992 VL 55 IS 11 BP 1569 EP 1581 DI 10.1021/np50089a003 PG 13 WC Plant Sciences; Chemistry, Medicinal; Pharmacology & Pharmacy SC Plant Sciences; Pharmacology & Pharmacy GA JZ557 UT WOS:A1992JZ55700003 PM 1336040 ER PT J AU ZABIELSKI, CV AF ZABIELSKI, CV TI METALLURGICAL CHARACTERIZATION OF THERMOMECHANICALLY PROCESSED U-0.75 WT-PERCENT-TI SO JOURNAL OF NUCLEAR MATERIALS LA English DT Article AB The objective of this study was to develop higher strength U-0.75 wt.% Ti by thermomechanical procedures. The approach was to replace the conventional solution treated, quenched, and aged (STA) process for U-0.75 wt.% Ti with warm rolling and warm or cold swaging. The effect of working on structure, hardness, tensile properties, compressive strength, and fracture toughness was determined. Deformation strengthening of previously hot-extruded and slow-cooled U-0.75 wt.% Ti was found to significantly increase the hardness, the tensile and compressive yield strengths, the ultimate tensile strength, and the reduction in area. There was no appreciable change in fracture toughness. The combinations of strength, ductility, and toughness obtained by deformation strengthening of this as-extruded material were generally inferior to those characteristic of STA processing. U-0.75 wt.% Ti, which was solution treated, water quenched, and warm rolled to a large reduction and then cold swaged, achieved the highest values in hardness, tensile and compressive yield strength, and ultimate tensile strength. Fracture toughness values were comparable to the conventionally processed alloy and reduction in area values were significantly greater. Deformation strengthening of solution treated and quenched material resulted in substantially better combinations of strength, ductility, and toughness than those characteristic of STA processing. RP ZABIELSKI, CV (reprint author), USA,MAT TECHNOL LAB,MET RES BRANCH,WATERTOWN,MA 02172, USA. NR 9 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-3115 J9 J NUCL MATER JI J. Nucl. Mater. PD NOV PY 1992 VL 195 IS 3 BP 301 EP 311 DI 10.1016/0022-3115(92)90521-L PG 11 WC Materials Science, Multidisciplinary; Nuclear Science & Technology SC Materials Science; Nuclear Science & Technology GA KB693 UT WOS:A1992KB69300007 ER PT J AU MCDEVITT, GR HEIRONIMUS, JD TONEY, MO BILLINGSLEY, JL AF MCDEVITT, GR HEIRONIMUS, JD TONEY, MO BILLINGSLEY, JL TI DIFFUSE ABDOMINAL UPTAKE OF TECHNETIUM-99M-METHYLENE DIPHOSPHONATE IN A PATIENT ON CONTINUOUS AMBULATORY DIALYSIS DURING BONE-SCINTIGRAPHY SO JOURNAL OF NUCLEAR MEDICINE LA English DT Article ID METASTATIC CALCIFICATION; PULMONARY CALCIFICATION; PRIMARY HYPERPARATHYROIDISM; PERITONEAL-DIALYSIS; SCAN; ACCUMULATION; DISORDERS; EFFUSION AB Extra-skeletal uptake of bone seeking radiopharmaceuticals has been documented by scintigraphy. We present a case of diffuse uptake of Tc-99m-methylene diphosphonate (MDP) in the abdomen of a patient while undergoing continuous ambulatory peritoneal dialysis (CAPD) who had no symptoms or findings referable to the abdomen. We hypothesized that the 99mTc-MDP crossed the peritoneal membrane across a concentration gradient. An in-vitro simulation confirms that Tc-99m-MDP will cross a semi-permeable membrane. Diffuse uptake of Tc-99m-MDP may be a normal variant in patients on CAPD who have no signs or symptoms of peritonitis. RP MCDEVITT, GR (reprint author), USA,BROOKE ARMY MED CTR,DEPT RADIOL,NUCL MED SECT,FT SAM HOUSTON,TX 78234, USA. NR 34 TC 3 Z9 3 U1 0 U2 0 PU SOC NUCLEAR MEDICINE INC PI RESTON PA 1850 SAMUEL MORSE DR, RESTON, VA 20190-5316 SN 0161-5505 J9 J NUCL MED JI J. Nucl. Med. PD NOV PY 1992 VL 33 IS 11 BP 2052 EP 2054 PG 3 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA JW929 UT WOS:A1992JW92900034 PM 1432173 ER PT J AU LILLEY, JS PENGELLY, SL FISHER, P AF LILLEY, JS PENGELLY, SL FISHER, P TI GENERIC DEVELOPMENTAL TURBOJET FUEL CONTROL SO JOURNAL OF PROPULSION AND POWER LA English DT Article AB A personal computer (PC) based generic developmental fuel control system for expendable turbojet engines has been developed and demonstrated. This system provides a means of experimentally evaluating the engine hardware, fuel metering devices, control sensors, and control logic of turbojet missile propulsion systems independently of installation in the flight vehicle. The system is generic in nature to permit the evaluation of a variety of engine models (from various manufacturers), metering devices, and control algorithms with only minor adaptations. The design specifications for the fuel control system are presented. Detailed descriptions of the electronic hardware utilized are provided. A discussion of the software utilized in the system is presented. The software structure and the function of various programs are described in detail. An overview of the engine fuel control logic algorithms is given. The results of an experimental system evaluation are presented. C1 BOEING DEF & SPACE GRP,HUNTSVILLE,AL 35898. RP LILLEY, JS (reprint author), USA,MISSILE COMMAND,REDSTONE ARSENAL,AL 35898, USA. NR 4 TC 1 Z9 1 U1 0 U2 0 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091 SN 0748-4658 J9 J PROPUL POWER JI J. Propul. Power PD NOV-DEC PY 1992 VL 8 IS 6 BP 1258 EP 1265 DI 10.2514/3.11471 PG 8 WC Engineering, Aerospace SC Engineering GA JY976 UT WOS:A1992JY97600020 ER PT J AU VENNOS, EM COLLINS, M JAMES, WD AF VENNOS, EM COLLINS, M JAMES, WD TI ROTHMUND-THOMSON SYNDROME - REVIEW OF THE WORLD LITERATURE SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Review ID OSTEO-SARCOMA; DNA-REPAIR; POIKILODERMA-CONGENITALE; COCKAYNE SYNDROME; SENSITIVITY; DYSPLASIA; DISEASE; LIGHT; TELANGIECTASIA; FIBROBLASTS AB Rothmund-Thomson syndrome is a rare, inherited disorder characterized by poikilodermatous skin changes that appear in infancy. The inheritance is autosomal recessive. Patients exhibit variable features including skeletal abnormalities, juvenile cataracts, and a higher than expected incidence of malignancy. This extensive review of the world literature clarifies aspects of the inheritance, incidence of characteristic features, and malignant potential of this disease. Insight into its origin is provided through a review of the clinical and in vitro studies of endocrine function and possible DNA repair abnormalities. C1 WALTER REED ARMY MED CTR,DERMATOL SERV,WASHINGTON,DC 20307. NR 151 TC 103 Z9 108 U1 0 U2 2 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD NOV PY 1992 VL 27 IS 5 BP 750 EP 762 DI 10.1016/0190-9622(92)70249-F PN 1 PG 13 WC Dermatology SC Dermatology GA JV886 UT WOS:A1992JV88600017 PM 1430398 ER PT J AU VOGEL, PS NEMER, J SAU, P HNATIUK, O AF VOGEL, PS NEMER, J SAU, P HNATIUK, O TI CHURG-STRAUSS-SYNDROME SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Article ID ALLERGIC GRANULOMATOSIS; VASCULITIS SYNDROMES; CLASSIFICATION; EOSINOPHILIA; CRITERIA; ANGIITIS AB A 62-year-old woman who had a history of asthma and allergic rhinitis developed bilateral pulmonary infiltrates and marked eosinophilia. A transbronchial biopsy specimen did not help clarify the diagnosis. She later developed erythematous nodules on her feet; results of a biopsy specimen revealed necrotizing extravascular granulomas and marked infiltration of the dermis with eosinophils consistent with a diagnosis of Churg-Strauss syndrome. Skin manifestations are often nonspecific in this syndrome and occur in approximately two thirds of cases. C1 WALTER REED ARMY MED CTR,PATHOL SERV,WASHINGTON,DC 20307. OHIO STATE UNIV,SCH MED,COLUMBUS,OH 43210. RP VOGEL, PS (reprint author), WALTER REED ARMY MED CTR,DEPT DERMATOL,WASHINGTON,DC 20307, USA. NR 13 TC 7 Z9 7 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD NOV PY 1992 VL 27 IS 5 BP 821 EP 824 DI 10.1016/0190-9622(92)70256-F PN 2 PG 4 WC Dermatology SC Dermatology GA JV887 UT WOS:A1992JV88700007 PM 1469135 ER PT J AU LAGUTCHIK, MS MUNDIE, TG MARTIN, DG AF LAGUTCHIK, MS MUNDIE, TG MARTIN, DG TI METHEMOGLOBINEMIA INDUCED BY A BENZOCAINE-BASED TOPICALLY ADMINISTERED ANESTHETIC IN 8 SHEEP SO JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION LA English DT Article DE OVINE SPECIES; ANESTHESIA LOCAL; BENZOCAINE; METHEMOGLOBINEMIA ID DEFICIENCY; CATS; DOGS C1 WALTER REED ARMY INST RES,DIV MED,DEPT RESP RES,WASHINGTON,DC 20307. NR 23 TC 10 Z9 10 U1 0 U2 1 PU AMER VETERINARY MEDICAL ASSOC PI SCHAUMBURG PA 1931 N MEACHAM RD SUITE 100, SCHAUMBURG, IL 60173-4360 SN 0003-1488 J9 J AM VET MED ASSOC JI J. Am. Vet. Med. Assoc. PD NOV 1 PY 1992 VL 201 IS 9 BP 1407 EP 1410 PG 4 WC Veterinary Sciences SC Veterinary Sciences GA JW093 UT WOS:A1992JW09300021 PM 1429190 ER PT J AU JUNG, KH SHIH, S KWONG, DL GEORGE, T LIN, TL LIU, HY ZAVADA, J AF JUNG, KH SHIH, S KWONG, DL GEORGE, T LIN, TL LIU, HY ZAVADA, J TI PHOTOLUMINESCENCE, STRUCTURE, AND COMPOSITION OF LATERALLY ANODIZED POROUS SI SO JOURNAL OF THE ELECTROCHEMICAL SOCIETY LA English DT Article ID INTENSE PHOTOLUMINESCENCE; SILICON; ELECTROLUMINESCENCE; FILMS AB We have studied the photoluminescence (PL), structure, and composition of laterally anodized porous Si. Broad PL peaks were observed centered between approximately 620-720 nm with strong intensities measured from 500 to 860 nm. Macroscopic variations in PL intensities and peak positions are explained in terms of the structure and anodization process. Structural studies suggest that the PL appears to originate from a multilayered porous Si structure in which the top two layers are amorphous. X-ray diffraction spectra also suggest the presence of a significant amorphous phase. In addition to high concentrations of B and N, we have measured extremely high concentrations (>> 10(20) cm-3) of H, C, O, and F. Our results indicate that laterally anodized porous Si does not fit the crystalline Si quantum wire model prevalent in the literature, suggesting that some other structure is responsible for the observed luminescence. C1 JET PROP LAB,CTR SPACE MICROELECTR,PASADENA,CA 91109. TEXAS INSTRUMENTS INC,DALLAS,TX 75265. USA,RES OFF,RES TRIANGLE PK,NC 27709. RP JUNG, KH (reprint author), UNIV TEXAS,DEPT ELECT & COMP ENGN,MICROELECTR RES CTR,AUSTIN,TX 78712, USA. NR 49 TC 25 Z9 25 U1 0 U2 0 PU ELECTROCHEMICAL SOC INC PI PENNINGTON PA 10 SOUTH MAIN STREET, PENNINGTON, NJ 08534 SN 0013-4651 J9 J ELECTROCHEM SOC JI J. Electrochem. Soc. PD NOV PY 1992 VL 139 IS 11 BP 3363 EP 3372 DI 10.1149/1.2069079 PG 10 WC Electrochemistry; Materials Science, Coatings & Films SC Electrochemistry; Materials Science GA JX172 UT WOS:A1992JX17200060 ER PT J AU RASLEAR, TG SHURTLEFF, D SIMMONS, L AF RASLEAR, TG SHURTLEFF, D SIMMONS, L TI INTERTRIAL-INTERVAL EFFECTS ON SENSITIVITY (A') AND RESPONSE BIAS (B'') IN A TEMPORAL DISCRIMINATION BY RATS SO JOURNAL OF THE EXPERIMENTAL ANALYSIS OF BEHAVIOR LA English DT Article DE TIME DISCRIMINATION; INTERTRIAL INTERVAL; SIGNAL DETECTION; RESPONSE BIAS; LEVER PRESSING; RATS ID BISECTION AB Killeen and Fetterman's (1988) behavioral theory of animal timing predicts that decreases in the rate of reinforcement should produce decreases in the sensitivity (A') of temporal discriminations and a decrease in miss and correct rejection rates (decrease in bias toward "long" responses). Eight rats were trained on a 10- versus 0.1-s temporal discrimination with an intertrial interval of 5 s and were subsequently tested on probe days on the same discrimination with intertrial intervals of 1, 2.5, 5, 10, or 20 s. The rate of reinforcement declined for all animals as intertrial interval increased. Although sensitivity (A') decreased with increasing intertrial interval, all rats showed an increase in bias to make long responses. C1 USN,MED RES INST,WASHINGTON,DC 20350. RP RASLEAR, TG (reprint author), WALTER REED ARMY INST RES,DEPT MICROWAVE RES,WASHINGTON,DC 20307, USA. NR 11 TC 18 Z9 18 U1 0 U2 0 PU SOC EXP ANALYSIS BEHAVIOR INC PI BLOOMINGTON PA INDIANA UNIV DEPT PSYCHOLOGY, BLOOMINGTON, IN 47405 SN 0022-5002 J9 J EXP ANAL BEHAV JI J. Exp. Anal. Behav. PD NOV PY 1992 VL 58 IS 3 BP 527 EP 535 DI 10.1901/jeab.1992.58-527 PG 9 WC Psychology, Biological; Behavioral Sciences; Psychology, Experimental SC Psychology; Behavioral Sciences GA JY196 UT WOS:A1992JY19600010 PM 1447544 ER PT J AU LIPP, LJ AF LIPP, LJ TI METHODOLOGY FOR DEVELOPING A COMBINED ENVIRONMENTAL-STRESS SCHEDULE FOR RELIABILITY GROWTH TESTING .3. DESIGNING A RELIABILITY TEST SCHEDULE WITH COMBINED ENVIRONMENTAL SCHEDULES SO JOURNAL OF THE IES LA English DT Article DE TEST TAILORING; RELIABILITY GROWTH; MISSION PROFILES; VIBRATION AB This article, the third of a three-part series, discusses how to develop an integrated environmental test schedule for military ground mobile equipment. Part I described the equipment to be tested, provided a general overview of mission profiles, and identified appropriate climatic conditions. Part II discussed the complexities of the tracked-vehicle vibration environment, including research conducted in the Arizona desert and the Alaskan Arctic. Part III combines the information discussed in Parts I and II into combined environmental stress schedules. The first test schedule is "real-time" in that mean-time-between-failures (MTBF) could be approximated from the results, and the second test schedule attempts to find system weaknesses by deleting benign environments. RP LIPP, LJ (reprint author), USA,ARMAMENT MUNIT & CHEM COMMAND,ABERDEEN PROVING GROUND,MD 21010, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU INST ENVIRONMENTAL SCI PI MT PROSPECT PA 940 E NORTHWEST HIGHWAY, MT PROSPECT, IL 60056 SN 1052-2883 J9 J IES JI J. IES PD NOV-DEC PY 1992 VL 35 IS 6 BP 40 EP 44 PG 5 WC Engineering, Environmental; Environmental Sciences; Instruments & Instrumentation SC Engineering; Environmental Sciences & Ecology; Instruments & Instrumentation GA KB466 UT WOS:A1992KB46600003 ER PT J AU KOLKA, MA STEPHENSON, LA AF KOLKA, MA STEPHENSON, LA TI CARDIOVASCULAR AND THERMOREGULATORY RESPONSES TO REPEATED ANTICHOLINESTERASE ADMINISTRATION SO JOURNAL OF THERMAL BIOLOGY LA English DT Article DE ANTICHOLINESTERASE; EXERCISE; HEAT STRESS; SWEATING RATE; HUMAN ID SKIN BLOOD-FLOW; PYRIDOSTIGMINE; EXERCISE; HUMANS AB 1. Pyridostigmine administration decreased resting heart rate by 11 +/- 7 beats,min and resting oesophageal temperature by 0.23 +/- 12-degrees-C after 50 h (P < 0.05). In addition, red blood cell cholinesterase activity was decreased an average of 43 +/- 7% after 50 h of pyridostigmine treatment. 2. The lower heart rates and core temperatures at rest were continued during high intensity exercise in a 35-degrees-C environment. Whole body sweating was 12 +/- 18% higher (P = 0.20) during exercise in the heat after 50 h of pyridostigmine treatment. 3. Repeated anticholinesterase administration had little effect on cardiovascular and thermoregulatory responses during high intensity exercise. RP KOLKA, MA (reprint author), USA,DIV THERMAL PHYSIOL & MED,ENVIRONM MED RES INST,NATICK,MA 01760, USA. NR 18 TC 4 Z9 4 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0306-4565 J9 J THERM BIOL JI J. Therm. Biol. PD NOV PY 1992 VL 17 IS 6 BP 333 EP 337 DI 10.1016/0306-4565(92)90042-E PG 5 WC Biology; Zoology SC Life Sciences & Biomedicine - Other Topics; Zoology GA KF065 UT WOS:A1992KF06500008 ER PT J AU PROUT, GR BARTON, BA GRIFFIN, PP FRIEDELL, GH AF PROUT, GR BARTON, BA GRIFFIN, PP FRIEDELL, GH TI TREATED HISTORY OF NONINVASIVE GRADE-1 TRANSITIONAL CELL-CARCINOMA SO JOURNAL OF UROLOGY LA English DT Article DE CARCINOMA; TRANSITIONAL CELL; BLADDER NEOPLASMS ID FLUORESCENCE IMAGE-ANALYSIS; SUPERFICIAL BLADDER-CANCER; FLOW-CYTOMETRY; URINARY-BLADDER; PAPILLARY CARCINOMA; NATURAL-HISTORY; FOLLOW-UP; RECURRENCE; CYTOLOGY; TUMORS AB A total of 178 patients with grade 1 noninvasive (stage Ta) bladder tumors followed from 1 to 10 years (median 58 months) was prospectively evaluated by cystoscopy, transurethral resection, mucosal biopsies, cytology, size and number of tumors at diagnosis, recurrences, progression in grade and stage, number of negative or positive cystoscopies and death from all causes. Histopathological and cytological studies were confirmed by a Central Pathology Laboratory using the criteria for grade 1 as described previously. Of the patients 122 (68.5%) had a single tumor. Three-quarters of the patients had tumors of less than 2 cm., 95% had mild or no urothelial dysplasia and 1 had positive cytology results. There were 419 recurrent tumors in 109 patients (61%). Patients with multiple tumors were at a significantly greater risk for recurrences (p <0.001). Size of tumor significantly affected the rate of recurrence in the first 2 years after initial diagnosis in single tumor patients only. Of the multiple tumor patients 90% experienced a recurrence compared to 46% of the single tumor patients. Of the 1,112 cystoscopies performed in 122 single tumor patients 18% were positive, compared to 33% of the 686 cystoscopies performed in 56 multiple tumor patients. A total of 29 patients had a change in grade, 5 having grade 3 and 24 having grade 2 tumors. Progression to stage T1 occurred in 5 patients and to stage T2 or greater in 3. Of the 36 patients who died, 1 died of obstruction due to bladder cancer. Experimental evidence supports the opinion that the cells of stage Ta, grade 1 tumors are different in several ways from normal urothelium. There are little data to support the use of the term papilloma to describe stage Ta, grade 1 tumors without reservation. The data demonstrate that the tumor diathesis being expressed ceases with time and for unknown reasons. Multiple tumor patients with stage Ta, grade 1 disease might be included in chemotherapy trials only with stratification and a control arm of transurethral resection/fulguration alone. C1 MARYLAND MED RES INST,BALTIMORE,MD. MASSACHUSETTS GEN HOSP,BOSTON,MA 02114. VIRGINIA MASON RES CTR,SEATTLE,WA 98101. WALTER REED ARMY MED CTR,BETHESDA,MD. UNIV IOWA,IOWA CITY,IA 52242. RUSH PRESBYTERIAN ST LUKES MED CTR,CHICAGO,IL 60612. UNIV OREGON,PORTLAND,OR. NEW YORK STATE DEPT HLTH,ROSWELL PK MEM INST,BUFFALO,NY 14263. VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,RICHMOND,VA 23298. UNIV WISCONSIN,MADISON,WI 53706. UNIV FLORIDA,GAINESVILLE,FL 32611. UNIV KENTUCKY,LOUISVILLE,KY. CLEVELAND CLIN,CLEVELAND,OH 44106. UNIV TENNESSEE CTR HLTH SCI,MEMPHIS,TN 38163. FU NCI NIH HHS [CA15934, CA17466, CA23082] NR 49 TC 118 Z9 121 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-5347 J9 J UROLOGY JI J. Urol. PD NOV PY 1992 VL 148 IS 5 BP 1413 EP 1419 PG 7 WC Urology & Nephrology SC Urology & Nephrology GA JW460 UT WOS:A1992JW46000009 PM 1433540 ER PT J AU JONES, NL RICHARDS, DR AF JONES, NL RICHARDS, DR TI MESH GENERATION FOR ESTUARINE FLOW MODELING SO JOURNAL OF WATERWAY PORT COASTAL AND OCEAN ENGINEERING-ASCE LA English DT Article ID DELAUNAY TRIANGULATION AB A finite element computer modeling system called TABS-2 has been developed by the U.S. Army Engineer Waterways Experiment Station, Vicksburg, Mississippi. TABS-2 has been used to model shallow water flow in estuaries. Accurate modeling of the flow in estuaries using TABS-2 requires the use of very large two-dimensional finite element meshes. The task of constructing such meshes has traditionally been the most time-consuming and error-prone part of the modeling process. Most automatic mesh-generation schemes are not well suited for estuarine modeling because the regions modeled are typically highly complex and irregular. As a result, the meshes are often constructed manuallly by coding the mesh in an ASCII file. Manual construction of large meshes is very tedious and can take several weeks to complete. To overcome this difficulty, a mesh generation scheme well suited for estuarine modeling has been developed involving a triangulation algorithm and a variety of mesh editing tools. The scheme makes it possible to generate large meshes of several thousand elements in a relatively short period of time. In addition, the scheme results in meshes with favorable geometric properties, leading to stability and accurate solutions. C1 USA,WATERWAYS EXPT STN,HYDRAUL LAB,ESTUARINE SIMULAT BRANCH,VICKSBURG,MS 39180. RP JONES, NL (reprint author), BRIGHAM YOUNG UNIV,DEPT CIVIL ENGN,368 CLYDE BLDG,PROVO,UT 84602, USA. NR 11 TC 8 Z9 8 U1 0 U2 0 PU ASCE-AMER SOC CIVIL ENGINEERS PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-950X J9 J WATERW PORT C-ASCE JI J. Waterw. Port Coast. Ocean Eng.-ASCE PD NOV-DEC PY 1992 VL 118 IS 6 BP 599 EP 614 DI 10.1061/(ASCE)0733-950X(1992)118:6(599) PG 16 WC Engineering, Civil; Engineering, Ocean; Water Resources SC Engineering; Water Resources GA JU220 UT WOS:A1992JU22000003 ER PT J AU MATHER, B AF MATHER, B TI THE DETERMINATION OF THE MOST COMMON CRYSTALLINE ALKALI-SILICA REACTION-PRODUCT - DISCUSSION SO MATERIALS AND STRUCTURES LA English DT Letter RP MATHER, B (reprint author), USA,ENGINEER WATERWAYS EXPT STN,STRUCT LAB,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 4 TC 0 Z9 0 U1 0 U2 1 PU R I L E M PI CACHAN PA PAVILLON DES JARDINS, 61 AV DU PRESIDENT WILSON, 94235 CACHAN, FRANCE SN 0025-5432 J9 MATER STRUCT JI Mater. Struct. PD NOV PY 1992 VL 25 IS 153 BP 566 EP 567 DI 10.1007/BF02472453 PG 2 WC Construction & Building Technology; Engineering, Civil; Materials Science, Multidisciplinary SC Construction & Building Technology; Engineering; Materials Science GA JY999 UT WOS:A1992JY99900008 ER PT J AU PEGGINS, JO MCMAHON, TF WEINER, M LESKO, L AF PEGGINS, JO MCMAHON, TF WEINER, M LESKO, L TI THE EFFECTS OF AGE ON THE PHARMACOKINETICS AND BIOTRANSFORMATION OF THEOPHYLLINE INVIVO AND INVITRO IN THE MONGOLIAN GERBIL (MERIONES-UNGUICULATUS) SO MECHANISMS OF AGEING AND DEVELOPMENT LA English DT Article DE PHARMACOKINETICS; BIOTRANSFORMATION; THEOPHYLLINE; MONGOLIAN GERBIL (MERIONES-UNGUICULATUS) ID HEPATIC DRUG-METABOLISM; RAT-LIVER AB The effect of post maturational aging on the in vivo disposition of theophylline was examined in the Mongolian gerbils (Meriones unguiculatus) aged 30-39 (old), 12-18 (middle-aged) and 3 (young) months following a 21) mg/kg i.p. dose. Biotransformation of theophylline was also examined in liver microsomes from non-induced and 3-methylcholanthrene induced gerbils. Analysis of theophylline plasma kinetics showed decreased clearance, increased half-life and increased volume of distribution in old vs. young animals. Clearance to the 1,3-dimethyluric acid metabolite was similar for all age groups, while clearance to the 1-methyluric acid metabolite was significantly lower in the middle-aged group compared to that of young and old gerbils. Urinary recovery of 1-methylurate was increased in old vs. young and middle-aged animals while recovery of theophylline was decreased. 3-Methylcholanthrene induction resulted in decreased recovery Of theophylline and increased recovery of 1,3-dimethylurate and 1-methylurate in young and middle-aged gerbils compared to non-induced controls. Decreased microsomal protein content was observed in old vs. young and middle-aged gerbils and an age-related decrease in cytochrome P-450 content (nmol P-450/g liver) was also observed. The rate of dimethylurate formation was decreased 37% in microsomes from old vs. young and middle-aged gerbils. 3-Methylcholanthrene administration resulted in a 2- and 1.5-fold increase in the rate of 1,3-diniethylurate formation in young and middle-aged gerbils, respectively. The results of these experiments indicate that the Mongolian gerbil may be useful for the study of the biochemical mechanisms underlying age-related changes in the biotransformation and kinetics of theophylline. C1 US EPA,OFF PESTICIDE PROGRAMS,CRYSTAL CITY,VA. PHARMAKINET INC,BALTIMORE,MD. UNIV MARYLAND,SCH PHARM,DEPT PHARMACOL & TOXICOL,COLL PK,MD 20742. RP PEGGINS, JO (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307, USA. NR 22 TC 2 Z9 2 U1 0 U2 1 PU ELSEVIER SCI IRELAND LTD PI CLARE PA CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE, IRELAND SN 0047-6374 J9 MECH AGEING DEV JI Mech. Ageing. Dev. PD NOV PY 1992 VL 66 IS 2 BP 173 EP 186 DI 10.1016/0047-6374(92)90134-Y PG 14 WC Cell Biology; Geriatrics & Gerontology SC Cell Biology; Geriatrics & Gerontology GA KC272 UT WOS:A1992KC27200006 PM 1365843 ER PT J AU KENYON, RH RIPPY, MK MCKEE, KT ZACK, PM PETERS, CJ AF KENYON, RH RIPPY, MK MCKEE, KT ZACK, PM PETERS, CJ TI INFECTION OF MACACA-RADIATA WITH VIRUSES OF THE TICK-BORNE ENCEPHALITIS GROUP SO MICROBIAL PATHOGENESIS LA English DT Article DE MACACA-RADIATA; TICK-BORNE ENCEPHALITIS; PATHOGENESIS; KYASANUR FOREST DISEASE (KFD); RUSSIAN SPRING-SUMMER ENCEPHALITIS C1 USA,MED RES INST INFECT DIS,DIV PATHOL,FREDERICK,MD 21702. RP KENYON, RH (reprint author), USA,MED RES INST INFECT DIS,DIV DIS ASSESSMENT,FREDERICK,MD 21702, USA. NR 15 TC 24 Z9 24 U1 0 U2 1 PU ACADEMIC PRESS LTD PI LONDON PA 24-28 OVAL RD, LONDON, ENGLAND NW1 7DX SN 0882-4010 J9 MICROB PATHOGENESIS JI Microb. Pathog. PD NOV PY 1992 VL 13 IS 5 BP 399 EP 409 DI 10.1016/0882-4010(92)90083-Z PG 11 WC Immunology; Microbiology SC Immunology; Microbiology GA KR742 UT WOS:A1992KR74200007 PM 1297916 ER PT J AU ELKINS, KL WINEGAR, RK NACY, CA FORTIER, AH AF ELKINS, KL WINEGAR, RK NACY, CA FORTIER, AH TI INTRODUCTION OF FRANCISELLA-TULARENSIS AT SKIN SITES INDUCES RESISTANCE TO INFECTION AND GENERATION OF PROTECTIVE IMMUNITY SO MICROBIAL PATHOGENESIS LA English DT Note DE FRANCISELLA-TULARENSIS; TULAREMIA; INBRED MICE; PROTECTIVE IMMUNITY; SUBCUTANEOUS; INTRADERMAL; SKIN-ASSOCIATED LYMPHOID TISSUE (SALT) ID NATURAL-KILLER-CELLS; GAMMA; LYMPHOCYTES; ACTIVATION; VACCINE RP ELKINS, KL (reprint author), WALTER REED ARMY INST RES,DEPT CELLULAR IMMUNOL,9620 MED CTR DR,ROCKVILLE,MD 20850, USA. NR 17 TC 40 Z9 41 U1 0 U2 0 PU ACADEMIC PRESS LTD PI LONDON PA 24-28 OVAL RD, LONDON, ENGLAND NW1 7DX SN 0882-4010 J9 MICROB PATHOGENESIS JI Microb. Pathog. PD NOV PY 1992 VL 13 IS 5 BP 417 EP 421 DI 10.1016/0882-4010(92)90085-3 PG 5 WC Immunology; Microbiology SC Immunology; Microbiology GA KR742 UT WOS:A1992KR74200009 PM 1297917 ER PT J AU MISER, WF AF MISER, WF TI THE CONTENT OF OUTPATIENT FAMILY-PRACTICE CARE IN AN ARMY COMMUNITY-HOSPITAL - ONE PHYSICIANS 3-YEAR EXPERIENCE SO MILITARY MEDICINE LA English DT Article AB The purpose of this pilot study was to describe the 3-year experience of ambulatory medical care provided by one family physician in an Army community hospital. Data collected at each outpatient visit included the patient's age, race, gender, problems actively addressed, and procedures. There were 7,895 out-patient visits, representing 3,665 patients and 2,292 families. Of the 13,158 problems recorded, the 10 most frequent were pregnancy care, general medical examination, alcohol and tobacco use, hypertension, depression/anxiety, contraception, otitis media, acute upper respiratory infection, vaginitis, and headache. Further studies should be done to validate this pilot study. RP MISER, WF (reprint author), TRIPLER ARMY MED CTR,DEPT FAMILY PRACTICE,HSHK FM,HONOLULU,HI 96859, USA. RI Miser, William/E-3686-2011 NR 0 TC 1 Z9 1 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD NOV PY 1992 VL 157 IS 11 BP 593 EP 597 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA JY325 UT WOS:A1992JY32500016 PM 1470354 ER PT J AU CRAIG, T SITZ, K SQUIRE, E SMITH, L CARPENTER, G AF CRAIG, T SITZ, K SQUIRE, E SMITH, L CARPENTER, G TI VOCAL CORD DYSFUNCTION DURING WARTIME SO MILITARY MEDICINE LA English DT Article AB Vocal cord dysfunction [VCD] often masquerades as asthma. The diagnosis is rarely suspected, but should be considered in cases of asthma that present atypically or that fail to respond to standard therapy. The frequency of VCD would be expected to increase during times of stress, including periods of war, since it is thought to be a conversion reaction. A high level of suspicion for VCD is essential to make the diagnosis so as to avoid unnecessary, potentially toxic medications and to direct the patient to prompt psychiatric care, which along with speech therapy, is the cornerstone of care. RP CRAIG, T (reprint author), WALTER REED ARMY MED CTR,ALLERGY IMMUNOL SERV,WASHINGTON,DC 20307, USA. NR 0 TC 19 Z9 19 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD NOV PY 1992 VL 157 IS 11 BP 614 EP 616 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA JY325 UT WOS:A1992JY32500022 PM 1470359 ER PT J AU ZALOZNIK, AJ GIUDICE, RO AF ZALOZNIK, AJ GIUDICE, RO TI GASTRIC HODGKINS-DISEASE - RECURRENCE AFTER AUTOLOGOUS BONE-MARROW TRANSPLANT SO MILITARY MEDICINE LA English DT Article AB Gastric involvement in Hodgkin's disease is rare. A case of gastric Hodgkin's disease occurring after autologous bone marrow transplantation is presented. A retrospective review of 339 cases of Hodgkin's disease in the Tumor Registry at Brooke Army Medical Center revealed six additional cases of documented gastric involvement. These six cases plus the case report are reviewed as well as the available literature on gastric Hodgkin's disease. RP ZALOZNIK, AJ (reprint author), USA,MEDDAC,FT IRWIN,CA 92310, USA. NR 0 TC 2 Z9 2 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD NOV PY 1992 VL 157 IS 11 BP 617 EP 619 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA JY325 UT WOS:A1992JY32500023 PM 1470360 ER PT J AU SHANLEY, DJ ELINE, MJ AF SHANLEY, DJ ELINE, MJ TI INTRACEREBRAL HEMATOMA LOCALIZATION AND REMOVAL USING INTRAOPERATIVE ULTRASOUND SO MILITARY MEDICINE LA English DT Article AB Intraoperative ultrasound can be used to localize central nervous system lesions such as hematomas, abscesses, aneurysms, and tumors. High-resolution transducers can differentiate between the echogenic pattern of the normal brain parenchyma and the abnormal pattern of the lesion. When removal of the lesion is necessary, ultrasound can provide an accurate means of localization and immediate evaluation of the surgical site. The following case is presented as an example of the growing use of ultrasound in neurosurgery. C1 TRIPLER ARMY MED CTR,DEPT RADIOL,HONOLULU,HI 96859. NR 0 TC 1 Z9 1 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD NOV PY 1992 VL 157 IS 11 BP 622 EP 624 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA JY325 UT WOS:A1992JY32500025 PM 1470362 ER PT J AU ANDERSON, CE WALKER, JD HAUVER, GE AF ANDERSON, CE WALKER, JD HAUVER, GE TI TARGET RESISTANCE FOR LONG-ROD PENETRATION INTO SEMIINFINITE TARGETS SO NUCLEAR ENGINEERING AND DESIGN LA English DT Article; Proceedings Paper CT POST-CONF SEMINAR ON IMPACT AND LARGE DEFORMATION MECHANICS OF THE 11TH INTERNATIONAL CONF ON STRUCTURAL MECHANICS IN REACTOR TECHNOLOGY CY AUG 26-27, 1991 CL TOKYO, JAPAN AB An important parameter in the one-dimensional modified-Bernoulli penetration theory of Tate is the target resistance R(t). In the model, it is assumed that R(t) remains constant during the total penetration event. In this paper, a parametric study using the Tate model is used to show that the total depth of penetration is sensitive to the value of R(t). Time-resolved depth-of-penetration experiments and numerical simulations are used to examine R(t) as a function of penetration depth for long-rod tungsten-alloy projectiles impacting semi-infinite targets of S-7 steel and a titanium alloy. It is found in these studies that R(t) changes considerably during penetration and that the values which are used in predicting penetration performance must be considered to be an average value over the entire penetration profile. C1 USA,BALLIST RES LAB,TERMINAL BALLIST LAB,ABERDEEN PROVING GROUND,MD 21005. RP ANDERSON, CE (reprint author), SW RES INST,PO DRAWER 28510,SAN ANTONIO,TX 78228, USA. NR 15 TC 17 Z9 17 U1 2 U2 8 PU ELSEVIER SCIENCE SA LAUSANNE PI LAUSANNE 1 PA PO BOX 564, 1001 LAUSANNE 1, SWITZERLAND SN 0029-5493 J9 NUCL ENG DES JI Nucl. Eng. Des. PD NOV PY 1992 VL 138 IS 1 BP 93 EP 104 DI 10.1016/0029-5493(92)90281-Y PG 12 WC Nuclear Science & Technology SC Nuclear Science & Technology GA KC650 UT WOS:A1992KC65000009 ER PT J AU CLINE, ME HERMAN, J SHAW, ER MORTON, RD AF CLINE, ME HERMAN, J SHAW, ER MORTON, RD TI STANDARDIZATION OF THE VISUAL ANALOG SCALE SO NURSING RESEARCH LA English DT Article ID DYSPNEA C1 USA,NURSE CORPS,WASHINGTON,DC 20310. NR 7 TC 73 Z9 75 U1 0 U2 7 PU AMER J NURSING CO PI NEW YORK PA 555 W 57TH ST, NEW YORK, NY 10019-2961 SN 0029-6562 J9 NURS RES JI Nurs. Res. PD NOV-DEC PY 1992 VL 41 IS 6 BP 378 EP 380 PG 3 WC Nursing SC Nursing GA KW084 UT WOS:A1992KW08400013 PM 1437591 ER PT J AU YODER, L AF YODER, L TI PRO-CITE (R) - A BIBLIOGRAPHIC MANAGEMENT PROGRAM - PERSONAL-BIBLIOG-SOFTWARE-INC SO NURSING RESEARCH LA English DT Book Review RP YODER, L (reprint author), BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU AMER J NURSING CO PI NEW YORK PA 555 W 57TH ST, NEW YORK, NY 10019-2961 SN 0029-6562 J9 NURS RES JI Nurs. Res. PD NOV-DEC PY 1992 VL 41 IS 6 BP 380 EP 380 PG 1 WC Nursing SC Nursing GA KW084 UT WOS:A1992KW08400016 ER PT J AU GUPTA, L WANG, JS CHARLES, A KISATSKY, P AF GUPTA, L WANG, JS CHARLES, A KISATSKY, P TI PROTOTYPE SELECTION-RULES FOR NEURAL NETWORK TRAINING SO PATTERN RECOGNITION LA English DT Article DE NEURAL NETWORKS; TRAINING; PROTOTYPES; AUTOMATIC TARGET RECOGNITION ID CLASSIFICATION AB Rules to select a set of training prototypes from a collection of training prototypes are developed so that a neural network classifier converges to a solution when pattern classes overlap in feature space. The rules are especially useful for selecting training prototypes in order to improve the network robustness and operational flexibility by retraining the network with noisy prototypes. The formulation of the selection rules are based on a distortion measure and the network response to the training prototype collection. The application and effectiveness of the selection rules are demonstrated on a synthetic pattern classification in a Gaussian noise problem and a practical automatic target recognition problem. C1 USA,CTR ARMAMENT DEV & ENGN,DIV PRECIS MUNIT,SEEKER SENSOR SECT,PICATINNY ARSENAL,NJ 07806. RP GUPTA, L (reprint author), SO ILLINOIS UNIV,DEPT ELECT ENGN,CARBONDALE,IL 62901, USA. NR 7 TC 4 Z9 4 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0031-3203 J9 PATTERN RECOGN JI Pattern Recognit. PD NOV PY 1992 VL 25 IS 11 BP 1401 EP 1408 DI 10.1016/0031-3203(92)90152-9 PG 8 WC Computer Science, Artificial Intelligence; Engineering, Electrical & Electronic SC Computer Science; Engineering GA KE699 UT WOS:A1992KE69900012 ER PT J AU BEDEKAR, MM SAFARI, A WILBER, W AF BEDEKAR, MM SAFARI, A WILBER, W TI SUPERCONDUCTING THIN-FILMS OF BI-SR-CA-CU-O BY LASER ABLATION SO PHYSICA C LA English DT Article ID PREPARED INSITU; DEPOSITION; GROWTH AB Superconducting thin films of Bi-Sr-Ca-Cu-O have been deposited by KrF excimer laser ablation. The best in situ films showed a T(c)onset of 110 K and a T(c)(0) of 76 K. A study of the laser plume revealed the presence of two distinct regimes. The forward directed component increased with fluence and the film composition was stoichiometric in this region. This is in agreement with the results on the 123 system by Venkatesan et al. [1]. The film properties were found to be critically dependent on the substrate temperature and temperatures close to melting gave rise to 2212 and 2223 phases. At lower temperatures, 2201 and amorphous phases were obtained. The film morphology and superconducting properties were a function of the target to substrate distance and the oxygen pressure during deposition and cooling. An increase in the target to substrate distance led to a deterioration of the properties due to the energy considerations for the formation of 2212 and 2223 phases. The best films were obtained using cooling pressures of 700 Torr. The microwave surface resistance of the films measured at 35 GHz dropped below that of copper at 30 K. Film growth was studied using X-ray diffraction and STM/AFM. This work is a discussion of the role of the different variables on the film properties. C1 USA,ELECTR TECHNOL & DEVICES LAB,FT MONMOUTH,NJ 07703. RP BEDEKAR, MM (reprint author), RUTGERS STATE UNIV,DEPT CERAM,PISCATAWAY,NJ 08855, USA. NR 23 TC 16 Z9 16 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0921-4534 J9 PHYSICA C JI Physica C PD NOV 1 PY 1992 VL 202 IS 1-2 BP 42 EP 50 DI 10.1016/0921-4534(92)90294-M PG 9 WC Physics, Applied SC Physics GA JW985 UT WOS:A1992JW98500007 ER PT J AU KRIEGER, JB LI, Y IAFRATE, GJ AF KRIEGER, JB LI, Y IAFRATE, GJ TI SYSTEMATIC APPROXIMATIONS TO THE OPTIMIZED EFFECTIVE POTENTIAL - APPLICATION TO ORBITAL-DENSITY-FUNCTIONAL THEORY SO PHYSICAL REVIEW A LA English DT Article AB The integral equation originally derived by Sharp and Horton for the optimized effective potential (OEP) is exactly transformed into an equivalent form from which it is manifestly clear that the OEP, V(xsigma)0(r), is an implicit functional of only {n(isigma)}, the orbital densities of the occupied states {psi(isigma)}, and the corresponding single-particle exchange potentials {upsilon(isigma)}. Furthermore, the transformed OEP has exactly the same form as one recently developed by the authors [Phys. Rev. A 45, 101 (1992)] from a more heuristic approach, the only difference being that in the present work a term proportional to the gradient of n(isigma) is added to each upsilon(isigma), whose average value when taken over the isigma state is zero. This result leads to the natural development of an iterative approximation for V(xsigma)0, with the zeroth approximation being given by our previous result. The application of this technique to the calculation of the total energy and highest-energy single-particle eigenvalue for selected atoms is presented. In addition, we note that our results are applicable to the calculation of the OEP for any assumed exchange-correlation functional E(xc)[{psi(isigma)}], where upsilon(isigma) is taken as the appropriate functional derivative of E(xc). In the case that E(xc) is a functional of {n(isigma)} only, as in the case of the local-density approximation with self-interaction correction, the resulting V(xcsigma)0 is a functional of the {n(isigma)} only. C1 USA, RES OFF, RES TRIANGLE PK, NC 27709 USA. RP CUNY BROOKLYN COLL, DEPT PHYS, BROOKLYN, NY 11210 USA. NR 15 TC 283 Z9 284 U1 2 U2 10 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 2469-9926 EI 2469-9934 J9 PHYS REV A JI Phys. Rev. A PD NOV 1 PY 1992 VL 46 IS 9 BP 5453 EP 5458 DI 10.1103/PhysRevA.46.5453 PG 6 WC Optics; Physics, Atomic, Molecular & Chemical SC Optics; Physics GA JX834 UT WOS:A1992JX83400028 ER PT J AU GENOVESE, RF PETRAS, JM TORTELLA, FC AF GENOVESE, RF PETRAS, JM TORTELLA, FC TI EVALUATION OF TRANSIENT FOREBRAIN ISCHEMIA INDUCED BY 4 VESSEL OCCLUSION USING SCHEDULE-CONTROLLED BEHAVIOR SO PHYSIOLOGY & BEHAVIOR LA English DT Note DE ISCHEMIA; OPERANT BEHAVIOR; SCHEDULES OF REINFORCEMENT ID WORKING MEMORY; HIPPOCAMPAL DAMAGE; CEREBRAL-ISCHEMIA; NEURONAL DAMAGE; RATS; PERFORMANCE; IMPAIRMENT; INJURY; MODEL; SCOPOLAMINE AB Transient (5-min) global forebrain ischemia, induced by four- vessel occlusion, was assessed using a multiple fixed-ratio, fixed-interval schedule of food presentation in five rats. Under control conditions, the schedule produced distinctive response rates in each schedule component. Initially, ischemia disrupted responding under both schedule components, and to approximately the same degree. In general, total session responses returned to pre-occlusion levels during the course of 45 post-occlusion days, however, response rates under the fixed-interval component showed slightly less recovery than those under the fixed-ratio component. Histological assessment revealed considerable variability in hippocampal damage between rats. Severe damage in the CA1, CA2, and CA3 formations was observed in a single rat, and that rat also showed the greatest degree of response disruption. These results suggest that schedule-controlled responding may be a valuable method for assessing the effects of ischemic injury, and thus, putative neuroprotective compounds, on complex behavior. RP GENOVESE, RF (reprint author), WALTER REED ARMY INST RES,DEPT MED NEUROSCI,WASHINGTON,DC 20307, USA. NR 28 TC 10 Z9 10 U1 1 U2 3 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0031-9384 J9 PHYSIOL BEHAV JI Physiol. Behav. PD NOV PY 1992 VL 52 IS 5 BP 1025 EP 1028 DI 10.1016/0031-9384(92)90386-G PG 4 WC Psychology, Biological; Behavioral Sciences SC Psychology; Behavioral Sciences GA JZ482 UT WOS:A1992JZ48200029 PM 1484834 ER PT J AU PLETNEV, AG BRAY, M HUGGINS, J LAI, CJ AF PLETNEV, AG BRAY, M HUGGINS, J LAI, CJ TI CONSTRUCTION AND CHARACTERIZATION OF CHIMERIC TICK-BORNE ENCEPHALITIS DENGUE TYPE-4 VIRUSES SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE DENGUE VIRUS; TICK-BORNE ENCEPHALITIS VIRUS; VIRAL CHIMERA; NEUROVIRULENCE; PROTECTIVE IMMUNITY ID STRUCTURAL PROTEINS; NONSTRUCTURAL PROTEINS; NUCLEOTIDE-SEQUENCE; MICE; FLAVIVIRUS; GENES; NS1; RNA; IMMUNIZATION; POLYPROTEIN AB Dengue type 4 virus (DEN4) cDNA was used as a vector to express genes of the distantly related tick-borne encephalitis virus (TBEV). Full-length chimerk TBEV/DEN4 cDNAs were constructed by substituting TBEV genes coding for proteins such as capsid (C); pre-membrane, which is the precursor of membrane (M); envelope (E); or nonstructural protein NS1 for the corresponding DEN4 sequences. RNA transcripts prepared from cDNAs were used to transfect permissive simian cells. Two viable chimeric viruses that contained TBEV CME or ME genes were recovered. Compared with DEN4, chimeric TBE(ME)/DEN4 virus [designated vTBE(ME)/DEN4] produced larger plaques and grew to higher titer in simian cells. In contrast, vTBE(ME)/DEN4 produced smaller plaques on mosquito cells and grew to lower titer than DEN4. Analysis of viral RNA and proteins produced in vTBE(ME)/DEN4- and DEN4-infected mosquito or simian cells revealed that the chimera was restricted in its ability to enter and replicate in mosquito cells. In contrast, vTBE(ME)/DEN4 entered simian cells efficiently and its RNA was replicated more rapidly in these cells than was parental DEN4 RNA. Following intracerebral inoculation, vTBE(ME)/DEN4 caused fatal encephalitis in both suckling and adult mice, while nearly all mice inoculated by the same route with DEN4 did not develop disease. Unlike wild-type TBEV, vTBE(ME)/DEN4 did not cause encephalitis when adult mice were inoculated by a peripheral route. Adult mice previously inoculated with the chimera by a peripheral route were completely resistant to subsequent intraperitoneal challenge with 10(3) times the median lethal dose of TBEV, whereas mice previously inoculated with DEN4 were not protected. These findings indicate that (i) the TBEV M and E genes of the chimeric virus are major protective antigens and induce resistance to lethal TBEV challenge and (ii) other regions of the TBEV genome are essential for the ability of this virus to spread from a peripheral site to the brain. Success in constructing a viable TBEV/DEN4 chimera that retains the protective antigens of TBEV but lacks its peripheral invasiveness provides a strategy for the development of live attenuated TBEV vaccines. C1 RUSSIAN ACAD SCI,NOVOSIBIRSK INST BIOORGAN CHEM,NOVOSIBIRSK 630090,USSR. USA,MED RES INST INFECT DIS,FREDERICK,MD 21702. RP PLETNEV, AG (reprint author), NIAID,INFECT DIS LAB,MOLEC VIRAL BIOL SECT,BETHESDA,MD 20892, USA. NR 30 TC 103 Z9 107 U1 0 U2 2 PU NATL ACAD PRESS PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD NOV 1 PY 1992 VL 89 IS 21 BP 10532 EP 10536 DI 10.1073/pnas.89.21.10532 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA JW798 UT WOS:A1992JW79800114 PM 1438242 ER PT J AU CARETTI, DM SZLYK, PC SILS, IV AF CARETTI, DM SZLYK, PC SILS, IV TI EFFECTS OF EXERCISE MODALITY ON PATTERNS OF VENTILATION AND RESPIRATORY TIMING SO RESPIRATION PHYSIOLOGY LA English DT Article DE CONTROL OF BREATHING, PATTERN, EXERCISE; EXERCISE, MODE, PATTERN OF BREATHING; MAMMALS, HUMANS; PATTERN OF BREATHING, EXERCISE MODES ID AWAKE CATS; COMPONENTS; RHYTHM AB Ventilatory patterns and respiratory timing were measured in 14 subjects during cycling (CYC) and treadmill exercise (TM) at similar leg frequencies (fLEG) to determine if mode of exercise affects patterns of ventilation and respiratory timing. Measurements of breathing frequency (fR), tidal volume (VT), expired ventilation (VE), and inspiratory (TI) and expiratory (TE) time were obtained at fLEG of 50, 70, and 90 rev.min-1 (rpm) for CYC and at similar incremental fLEG (strides.min-1; spm) during TM achieved by increasing belt speed at 0% grade. CYC exercise intensity was approximately 50% V(O2,max) at all fLEG, whereas V(O2) increased progressively with TM. fR increased significantly (P<0.001) with increasing fLEG of TM (20.5 +/- 4.6, 25.4 +/- 5.8, and 36.3 +/- 7.6 breaths.min-1; xBAR +/- SD), but during CYC fR changed significantly (P<0.05) only between fLEG of 70 and 90 rpm (25.0 +/- 5.9 vs 28.5 +/- 6.9 breaths.min-1). Both average breath TI and TE obtained by grouping into incremental ranges of fR decreased significantly (P<0.05) with increasing fR up to 36 breaths.min-1 and the relationships of TI and TE to fR, TI to TE, and central inspiratory drive (VT/TI) to VE were the same for CYC and TM. Group average fR and fLEG were synchronized during TM, but individual subjects did not exhibit a high degree of entrainment. This study shows respiratory timing patterns to be independent of mode of exercise over the range of fR observed when describing patterns by grouping into incremental ranges of fR. C1 USA,ENVIRONM MED RES INST,DIV COMPARAT PHYSIOL,NATICK,MA 01760. NR 19 TC 6 Z9 6 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0034-5687 J9 RESP PHYSIOL JI Respir. Physiol. PD NOV PY 1992 VL 90 IS 2 BP 201 EP 211 DI 10.1016/0034-5687(92)90081-7 PG 11 WC Physiology; Respiratory System SC Physiology; Respiratory System GA KA554 UT WOS:A1992KA55400006 PM 1494720 ER PT J AU GREENE, SK SINGLETON, J SOBKOWICZ, P GOLDING, TD PEPPER, M PERENBOOM, JAAJ DINAN, J AF GREENE, SK SINGLETON, J SOBKOWICZ, P GOLDING, TD PEPPER, M PERENBOOM, JAAJ DINAN, J TI SUBBAND OCCUPANCIES AND ZERO-FIELD SPIN SPLITTING IN INSB-CDTE HETEROJUNCTIONS - MAGNETOTRANSPORT EXPERIMENTS AND SELF-CONSISTENT CALCULATIONS SO SEMICONDUCTOR SCIENCE AND TECHNOLOGY LA English DT Article ID NARROW-GAP SEMICONDUCTORS; INVERSION-LAYERS; GAAS-ALXGA1-XAS HETEROSTRUCTURES; WEAK LOCALIZATION; CHARGE LAYERS; ELECTRON-GAS; RESONANCE; SYSTEMS; MAGNETORESISTANCE; SUPERLATTICES AB A variety of magnetotransport measurements have been performed on InSb-CdTe heterojunctions containing high mobility (approximately 20 000 cm2 V-1 s-1) two-dimensional electron gases (2DEGS) with low areal carrier densities (N(s) approximately 1.8-4.2 x 10(11) cm-2). The experimental data have been compared with self-consistent calculations of the energy levels carried out using the 'three-band' model of narrow-gap semiconductors. The 2DEGS in the samples exhibit well resolved quantum Hall plateaux and Shubnikov-de Haas oscillations at temperatures below 5 K; using these data and the persistent photoconductivity (PPC) effect, the subband occupancies have been evaluated as functions of N(s). Parallel-field magnetoresistance measurements show that only two subbands are occupied, even at the highest carrier densities, and indicate the importance of intersubband scattering. The self-consistent calculations predict the number of occupied subbands correctly, and are in good agreement with the experimental subband occupancies when the effects of a small amount of interdiffusion are taken into account. The low-field magnetoresistance of the heterojunctions is at first positive and then negative; this is characteristic of weak localization in the presence of spin-orbit scattering. An analysis of the data indicates that this is caused by a spin splitting of the subbands at the Fermi energy, present even in zero magnetic field, and of order 2-4 meV The splitting results from three distinct mechanisms, two of which are included exactly in the self-consistent calculations. The calculations reproduce the size of the observed splitting reasonably well, indicating that these two terms are the dominant contributions to the effect. In addition, the third mechanism, not included in the self-consistent model, has been estimated to give splittings approximately 1 meV. These results illustrate the importance of the zero-field spin splitting in narrow-gap semiconductor space-charge layers. C1 UNIV OXFORD,CLARENDON LAB,OXFORD,ENGLAND. CATHOLIC UNIV NIJMEGEN,HIGH FIELD MAGNET LAB,6525 ED NIJMEGEN,NETHERLANDS. POLISH ACAD SCI,INST PHYS,PL-02668 WARSAW,POLAND. USA,CTR NIGHT VIS & ELECTROOPT,AMSEL RD NV IT,FT BELVOIR,VA 22060. CATHOLIC UNIV NIJMEGEN,MAT RES INST,6525 ED NIJMEGEN,NETHERLANDS. RP GREENE, SK (reprint author), UNIV CAMBRIDGE,CAVENDISH LAB,MADINGLEY RD,CAMBRIDGE CB3 0HE,ENGLAND. RI Sobkowicz, Pawel/G-5276-2010 OI Sobkowicz, Pawel/0000-0002-7275-7235 NR 48 TC 6 Z9 6 U1 1 U2 9 PU IOP PUBLISHING LTD PI BRISTOL PA TECHNO HOUSE, REDCLIFFE WAY, BRISTOL, ENGLAND BS1 6NX SN 0268-1242 J9 SEMICOND SCI TECH JI Semicond. Sci. Technol. PD NOV PY 1992 VL 7 IS 11 BP 1377 EP 1385 DI 10.1088/0268-1242/7/11/016 PG 9 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Condensed Matter SC Engineering; Materials Science; Physics GA JY318 UT WOS:A1992JY31800016 ER PT J AU SHAFFER, RT CARROUGHER, JG KADAKIA, SC GOODMAN, ZD AF SHAFFER, RT CARROUGHER, JG KADAKIA, SC GOODMAN, ZD TI AN OBESE 14-YEAR-OLD GIRL WITH PERSISTENTLY ELEVATED LIVER-ASSOCIATED ENZYMES SO SEMINARS IN LIVER DISEASE LA English DT Review ID NONALCOHOLIC FATTY LIVER; MORBID-OBESITY; DIABETES-MELLITUS; JEJUNOILEAL BYPASS; HEPATIC MORPHOLOGY; WEIGHT-LOSS; FOLLOW-UP; DISEASE; STEATOHEPATITIS; CIRRHOSIS C1 ARMED FORCES INST PATHOL,DEPT HEPAT & GASTROINTESTINAL PATHOL,DIV HEPAT PATHOL,WASHINGTON,DC 20306. BROOKE ARMY MED CTR,DEPT MED,GASTROENTEROL SECT,FT SAM HOUSTON,TX 78234. ARMED FORCES INST PATHOL,VET ADM SPECIAL REFERENCE LAB PATHOL,WASHINGTON,DC 20306. NR 65 TC 1 Z9 1 U1 0 U2 0 PU THIEME MEDICAL PUBL INC PI NEW YORK PA 381 PARK AVE SOUTH, NEW YORK, NY 10016 SN 0272-8087 J9 SEMIN LIVER DIS JI Semin. Liver Dis. PD NOV PY 1992 VL 12 IS 4 BP 429 EP 434 DI 10.1055/s-2008-1040412 PG 6 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA KD874 UT WOS:A1992KD87400010 PM 1361243 ER PT J AU MORRIS, JT LONGFIELD, RN AF MORRIS, JT LONGFIELD, RN TI DISSEMINATED INFECTION DUE TO MYCOBACTERIUM-CHELONEI SO SOUTHERN MEDICAL JOURNAL LA English DT Article ID BLOOD CULTURE SYSTEMS RP MORRIS, JT (reprint author), BROOKE ARMY MED CTR,INFECT DIS SERV,FT SAM HOUSTON,TX 78234, USA. NR 9 TC 2 Z9 2 U1 0 U2 0 PU SOUTHERN MEDICAL ASSN PI BIRMINGHAM PA 35 LAKESHORE DR PO BOX 190088, BIRMINGHAM, AL 35219 SN 0038-4348 J9 SOUTHERN MED J JI South.Med.J. PD NOV PY 1992 VL 85 IS 11 BP 1138 EP 1139 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA JY923 UT WOS:A1992JY92300018 PM 1439955 ER PT J AU KNAPIK, JJ JONES, BH BAUMAN, CL HARRIS, JM AF KNAPIK, JJ JONES, BH BAUMAN, CL HARRIS, JM TI STRENGTH, FLEXIBILITY AND ATHLETIC INJURIES SO SPORTS MEDICINE LA English DT Article RP KNAPIK, JJ (reprint author), USA,ENVIRONM MED RES INST,DIV OCCUPAT MED,NATICK,MA 01760, USA. NR 0 TC 49 Z9 49 U1 1 U2 10 PU ADIS INTERNATIONAL LTD PI AUCKLAND PA 41 CENTORIAN DR, PRIVATE BAG 65901, MAIRANGI BAY, AUCKLAND 10, NEW ZEALAND SN 0112-1642 J9 SPORTS MED JI Sports Med. PD NOV PY 1992 VL 14 IS 5 BP 277 EP 288 DI 10.2165/00007256-199214050-00001 PG 12 WC Sport Sciences SC Sport Sciences GA JX033 UT WOS:A1992JX03300001 PM 1439396 ER PT J AU CIOFFI, WG BURLESON, DG JORDAN, BS MASON, AD PRUITT, BA AF CIOFFI, WG BURLESON, DG JORDAN, BS MASON, AD PRUITT, BA TI GRANULOCYTE OXIDATIVE ACTIVITY AFTER THERMAL-INJURY SO SURGERY LA English DT Article ID ALTERNATIVE COMPLEMENT PATHWAY; BURN INJURY; NEUTROPHIL ACTIVATION; DAMAGE AB Background Alterations in granulocyte function after thermal injury have been described We have serially studied the level of granulocyte cytosolic peroxidase activity in 23 thermally injured patients during the first 6 weeks after injury. The patients' mean age and burn size were 35.1 +/- 15.7 years and 41.6% +/- 16.8% (range, 18% to 88%), respectively. Fourteen patients had concomitant inhalation injury, and the overall mortality rate was 4.3%. Methods. Purified granulocytes were obtained from peripheral blood after red cell lysis and Ficoll-Hypaque (Pharmacia Inc., Piscataway, N.J.) gradient separation. Cells were loaded with dichlorofluorescin diacetate, and baseline fluorescence was measured by flow cytometry. After phorbol myristate acetate stimulation, fluorescence was measured again. Cells from unburned normal subjects were used as daily controls. Results. The data are expressed as percent of stimulated control granulocyte fluorescence. Unstimulated patient granulocytes demonstrated a significantly higher baseline activity than did unstimulated controls (22.9% vs 15.4%; p < 0.05). Mean fluorescence from stimulated granulocytes was 114% of the control values (p < 0.05). Conclusions. Granulocytes from thermally injured patients exhibited a baseline increase in cytosolic oxidase activity, suggesting in vivo activation and a greater than normal oxidase activity after in vitro stimulation. RP CIOFFI, WG (reprint author), USA,SGRD USC B,FT SAM HOUSTON,TX 78234, USA. NR 19 TC 27 Z9 27 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0039-6060 J9 SURGERY JI Surgery PD NOV PY 1992 VL 112 IS 5 BP 860 EP 865 PG 6 WC Surgery SC Surgery GA JX038 UT WOS:A1992JX03800004 PM 1440237 ER PT J AU YOURICK, JJ DAWSON, JS MITCHELTREE, LW AF YOURICK, JJ DAWSON, JS MITCHELTREE, LW TI SULFUR MUSTARD-INDUCED MICROVESICATION IN HAIRLESS GUINEA-PIGS - EFFECT OF SHORT-TERM NIACINAMIDE ADMINISTRATION SO TOXICOLOGY AND APPLIED PHARMACOLOGY LA English DT Article ID HYDROGEN-PEROXIDE; ENDOTHELIAL-CELLS; NAD+ LEVELS; DNA DAMAGE; NICOTINAMIDE; MECHANISMS; INJURY; MODEL C1 USA,MED RES INST CHEM DEF,COMPARAT PATHOL BRANCH,ABERDEEN PROVING GROUND,MD 21010. RP YOURICK, JJ (reprint author), USA,MED RES INST CHEM DEF,APPL PHARMACOL BRANCH,SGRD-UV-PA,ABERDEEN PROVING GROUND,MD 21010, USA. NR 24 TC 16 Z9 19 U1 0 U2 0 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0041-008X J9 TOXICOL APPL PHARM JI Toxicol. Appl. Pharmacol. PD NOV PY 1992 VL 117 IS 1 BP 104 EP 109 DI 10.1016/0041-008X(92)90223-F PG 6 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA JX895 UT WOS:A1992JX89500014 PM 1440603 ER PT J AU THOMPSON, WL PACE, JG AF THOMPSON, WL PACE, JG TI SUBSTANCES THAT PROTECT CULTURED-HEPATOCYTES FROM THE TOXIC EFFECTS OF MICROCYSTIN-LR SO TOXICOLOGY IN VITRO LA English DT Article ID BLUE-GREEN-ALGA; CYANOBACTERIUM NODULARIA-SPUMIGENA; ISOLATED RAT HEPATOCYTES; LIVER-CELLS; AERUGINOSA; PEPTIDE; DISPERSION; INVITRO; INVIVO; MICE AB Primary cultures of rat hepatocytes were used in a screen in vitro for agents which protect against the toxic effects of the hepatoxin microcystin-LR. Exposure of cells to microcystin-LR, a cyclic heptapeptide produced by blue-green algae, resulted in clustering of hepatocytes within 15 min of addition. This initial response was followed by disruption of cellular function (measured by a protein synthesis assay) and eventual loss of membrane integrity, resulting in leakage of cytosolic enzymes (measured by LDH release). The antibiotic rifampicin was effective in reducing LDH release and preventing cell clustering at concentrations as low as 2.0 muM. Cytochalasins provided some protection at 10 muM. However, microscopy revealed disruption of hepatocytes in the presence of cytochalasins alone, at or above this concentration. Bile acids. cholic acid and deoxycholate were protective at higher concentrations (0.1 mM), but when given alone caused some leakage of cytosolic enzymes. Di-naphthalene dyes, trypan blue and trypan red, had no detrimental effects on hepatocytes and showed some protection at 20 muM. Hepatic uptake of tritium-labelled microcystin-LR was suppressed by bile acids and rifampicin, providing further evidence that blocking or competing with bile acid uptake also prevents microcystin-LR association with, and toxicity in, isolated hepatocytes. Although all drugs tested worked to varying degrees, rifampicin was most effective in providing protection of hepatocytes from toxin at lower concentrations while having no detrimental effects on the cells when added alone. RP THOMPSON, WL (reprint author), USA,MED RES INST INFECT DIS,FT DETRICK,FREDERICK,MD 21702, USA. NR 27 TC 14 Z9 15 U1 0 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0887-2333 J9 TOXICOL IN VITRO JI Toxicol. Vitro PD NOV PY 1992 VL 6 IS 6 BP 579 EP & DI 10.1016/0887-2333(92)90071-X PG 0 WC Toxicology SC Toxicology GA KE967 UT WOS:A1992KE96700014 PM 20732161 ER PT J AU WING, DA PATEL, HC BASKIN, SI AF WING, DA PATEL, HC BASKIN, SI TI THE EFFECT OF PICRYLSULPHONIC ACID ON INVITRO CONVERSION OF CYANIDE TO THIOCYANATE BY 3-MERCAPTOPYRUVATE SULPHURTRANSFERASE AND RHODANESE SO TOXICOLOGY IN VITRO LA English DT Article AB This study indicates that 3-mercaptopyruvate sulphurtransferase (MPST; EC 2.8.1.2) activity may serve as a useful in vitro indicator for the analysis of cyanide detoxification to thiocyanate. The time course and capacity of MPST to detoxify cyanide was equal to or exceeded that of rhodanese. Picrylsulphonic acid strongly inhibited purified rhodanese, but in the presence of mercaptopyruvate, it could increase the formation of thiocyanate catalysed by MPST. Formation of thiocyanate by MPST followed a linear time course and had a linear relation to enzyme level. However, substrate dependence did not produce linear Lineweaver-Burk plots when either mercaptopyruvate or cyanide concentration was varied. The differential effect of picrylsulphonic acid on the activities of these two enzymes was confirmed by using a crude kidney extract as the source of both enzymes. Picrylsulphonic acid may provide a useful scientific tool to examine which sulphurtransferase is most responsible for the detoxification of cyanide. C1 USA,MED RES INST CHEM DEF,DIV PHARMACOL,ABERDEEN PROVING GROUND,MD 21010. NR 30 TC 7 Z9 7 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0887-2333 J9 TOXICOL IN VITRO JI Toxicol. Vitro PD NOV PY 1992 VL 6 IS 6 BP 597 EP 603 DI 10.1016/0887-2333(92)90073-Z PG 7 WC Toxicology SC Toxicology GA KE967 UT WOS:A1992KE96700016 PM 20732163 ER PT J AU WHITE, NJ CHAPMAN, D WATT, G AF WHITE, NJ CHAPMAN, D WATT, G TI THE EFFECTS OF MULTIPLICATION AND SYNCHRONICITY ON THE VASCULAR DISTRIBUTION OF PARASITES IN FALCIPARUM-MALARIA SO TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID PLASMODIUM-FALCIPARUM; CELL DEFORMABILITY AB The sequestration of erythrocytes containing mature forms of Plasmodium falciparum in the microvasculature of vital organs may cause large discrepancies between the peripheral blood parasite count and the total body parasite burden in falciparum malaria. Despite this, parasitaemia is widely used as an indicator of prognosis and response to treatment. A simple mathematical model describing the changes in circulating and sequestered parasite numbers during acute falciparum malaria is presented. The model uses two parameters only; the standard deviation (SD) of parasite age since merogony (schizogony) as a measure of synchronicity, and a multiplication factor each 48 h asexual life cycle. The model predicts that during the rising phase of the infection the ratio of circulating to sequestered parasites is dependent largely on the synchronicity of infection rather than multiplication rate, and that in synchronous infections parasitaemias will show considerable fluctuation when the mean stage of parasite development is in the second half of the asexual life cycle. The model fitted well to serial parasite counts from 4 patients with acute uncomplicated falciparum malaria whose infections failed to respond to ciprofloxacin. All four infections were synchronous (SD less-than-or-equal-to 4 h), and showed large fluctuations in parasitaemia over short periods related to synchronous sequestration and subsequent reinvasion following merogony. The parasite multiplication rate was determined mainly by the efficiency of merogony or merozoite invasion rather than clearance of circulating parasitized erythrocytes. This suggests that the spleen is relatively inactive during the rising phase of the infection. Quinine treatment did not prevent sequestration but did stop subsequent multiplication. Understanding changes in parasitaemia shortly after beginning antimalarial drug treatment in terms of this simple model may avoid misclassification of the therapeutic response. C1 CHO QUAN HOSP, CTR TROP DIS, WELLCOME CLIN RES UNIT, HO CHI MINH CITY, VIETNAM. UNIV OXFORD, NUFFIELD DEPT CLIN MED, OXFORD, ENGLAND. ARMED FORCES RES INST MED SCI, DEPT MED, BANGKOK 10400, THAILAND. RP WHITE, NJ (reprint author), MAHIDOL UNIV, FAC TROP MED, 420-6 RAJVITHI RD, BANGKOK 10400, THAILAND. RI White, Nicholas/I-4629-2012 FU Wellcome Trust NR 27 TC 67 Z9 67 U1 0 U2 3 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND SN 0035-9203 EI 1878-3503 J9 T ROY SOC TROP MED H JI Trans. Roy. Soc. Trop. Med. Hyg. PD NOV-DEC PY 1992 VL 86 IS 6 BP 590 EP 597 DI 10.1016/0035-9203(92)90141-X PG 8 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA KF358 UT WOS:A1992KF35800007 PM 1287908 ER PT J AU BROWN, AE KAIN, KC PIPITHKUL, J WEBSTER, HK AF BROWN, AE KAIN, KC PIPITHKUL, J WEBSTER, HK TI DEMONSTRATION BY THE POLYMERASE CHAIN-REACTION OF MIXED PLASMODIUM-FALCIPARUM AND PLASMODIUM-VIVAX INFECTIONS UNDETECTED BY CONVENTIONAL MICROSCOPY SO TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID MALARIA AB Mixed malaria infections (Plasmodium falciparum and P. vivax) are suspected to occur at a greater frequency than is detected by conventional light microscopy. To determine this frequency we carried out a prospective 'blinded' comparison of diagnosis by conventional light microscopy and enzymatic amplification of the circumsporozoite gene extracted from dried spotted blood samples. Patients were previously healthy, active duty Thai soldiers assigned to a malaria risk area presenting with malaria. Microscopy (oil immersion objective at 1000 x magnification) involved examination of Giemsa-stained thick and thin blood films by an experienced microscopist. Whole blood samples (25 mul) dried on filter paper were used for species-specific parasite deoxyribonucleic acid (DNA) amplification by the polymerase chain reaction (PCR) and hybridization with radiolabelled P. falciparum and P. vivax probes. Of 137 consecutive cases of malaria studied, 9% (3/32) of microscopically diagnosed P. falciparum infections and 5% (5/104) of microscopically diagnosed P. vivax infections were found to be mixed by the PCR/DNA probe systems, while 1 case was diagnosed as mixed by both microscopy and PCR. The possibility that malaria patients may have undetected mixed infections should be kept in mind because of the specific therapy required both for P. falciparum and for radical cure of P. vivax. C1 ARMED FORCES INST MED SCI,DEPT IMMUNOL & PARASITOL,BANGKOK 10400,THAILAND. WALTER REED ARMY INST RES,DEPT IMMUNOL,WASHINGTON,DC 20307. NR 18 TC 98 Z9 105 U1 0 U2 1 PU ROYAL SOC TROPICAL MEDICINE PI LONDON PA MANSON HOUSE 26 PORTLAND PLACE, LONDON, ENGLAND W1N 4EY SN 0035-9203 J9 T ROY SOC TROP MED H JI Trans. Roy. Soc. Trop. Med. Hyg. PD NOV-DEC PY 1992 VL 86 IS 6 BP 609 EP 612 DI 10.1016/0035-9203(92)90147-5 PG 4 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA KF358 UT WOS:A1992KF35800011 PM 1287912 ER PT J AU CORWIN, A HABIB, M OLSON, J SCOTT, D KSIAZEK, T WATTS, DM AF CORWIN, A HABIB, M OLSON, J SCOTT, D KSIAZEK, T WATTS, DM TI THE PREVALENCE OF ARBOVIRAL, RICKETTSIAL, AND HANTAAN-LIKE VIRAL ANTIBODY AMONG SCHOOLCHILDREN IN THE NILE RIVER DELTA OF EGYPT SO TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID FEVER; INFECTION; SEROPREVALENCE; POPULATIONS AB A serosurvey was conducted during October and November 1989 to estimate the prevalence of selected arboviral, rickettsial, and Hantaan viral antibody among a sample of schoolchildren from 4 villages in the Bilbeis area of the Nile river delta, Egypt. Blood specimens were obtained from subjects aged 8 to 14 years. Enzyme immunoassay testing of the sera indicated that the prevalence of antibody was 9% (21/223) for Sicilian sandfly fever, 4% (8/223) for Rift Valley fever, 3% (15/437) for West Nile virus and 9% (28/315) for Hantaan (HTN) virus. Antibody was demonstrated among 22% (93/418) of the same study subjects against Coxiella burnetii, 53% (199/373) against Rickettsia typhi, and 37% (137/371) against R. conorii. C1 MINIST HLTH CAIRO,CTR FIELD & APPL RES,CAIRO,EGYPT. USA,MED RES INST INFECT DIS,FREDERICK,MD 21701. RP CORWIN, A (reprint author), USN,MED RES UNIT 3,RES PUBLICAT BRANCH,PSC 452 BOX 5000,FPO AE 09835-0007,CAIRO,EGYPT. NR 23 TC 18 Z9 18 U1 0 U2 1 PU ROYAL SOC TROPICAL MEDICINE PI LONDON PA MANSON HOUSE 26 PORTLAND PLACE, LONDON, ENGLAND W1N 4EY SN 0035-9203 J9 T ROY SOC TROP MED H JI Trans. Roy. Soc. Trop. Med. Hyg. PD NOV-DEC PY 1992 VL 86 IS 6 BP 677 EP 679 DI 10.1016/0035-9203(92)90189-J PG 3 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA KF358 UT WOS:A1992KF35800046 PM 1363163 ER PT J AU RIPPY, MK TOPPER, MJ MEBUS, CA MORRILL, JC AF RIPPY, MK TOPPER, MJ MEBUS, CA MORRILL, JC TI RIFT-VALLEY FEVER VIRUS-INDUCED ENCEPHALOMYELITIS AND HEPATITIS IN CALVES SO VETERINARY PATHOLOGY LA English DT Article DE CALVES; ENCEPHALOMYELITIS; HEPATITIS; RIFT VALLEY FEVER AB Three calves (Nos. 1, 2 = 7 days old; No. 3 = 21 days old) were inoculated subcutaneously with virulent Rift Valley fever (RVF) virus. All calves became viremic and clinically ill, but the two 7-day-old calves were moribund and were euthanatized subsequently on post-inoculation day (PID) 3. Highest viral titers were measured in the serum, with lesser concentrations in the brain, heart, spleen, and liver of these animals. Viral antigens were detected by immunohistochemical analysis only in the livers, where positive staining was localized in coalescing foci of hepatocellular necrosis. The 21-day-old calf appeared to recover after viremia and pyrexia but became lethargic and ataxic and was euthanatized on PID 9. The calf was no longer viremic, and RVF virus was isolated only from the brain. Microscopic examination of the central nervous system revealed diffuse perivascular infiltrates of lymphocytes and macrophages, multifocal meningitis, and focal areas of neuronal necrosis and aggregates of macrophages, lymphocytes, and neutrophils throughout all regions of the brain and cervical spinal cord. There was positive immunohistochemical staining for viral antigens within the cytoplasm of neurons and glial cells throughout the central nervous system. Thus, RVF virus can cause encephalomyelitis in calves, and the specific virologic diagnosis can be made by immunohistochemical localization of viral antigens in formalin-fixed tissues. C1 USA,MED RES INST INFECT DIS,DIV PATHOL,FREDERICK,MD 21701. USA,MED RES INST INFECT DIS,DIV DIS ASSESSMENT,FREDERICK,MD 21701. USDA ARS,PLUM ISL ANIM DIS CTR,PLUM ISL ANIM RES CTR,GREENPORT,NY 11944. NR 18 TC 24 Z9 24 U1 0 U2 1 PU AMER COLL VET PATHOLOGIST PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 SN 0300-9858 J9 VET PATHOL JI Vet. Pathol. PD NOV PY 1992 VL 29 IS 6 BP 495 EP 502 PG 8 WC Pathology; Veterinary Sciences SC Pathology; Veterinary Sciences GA JY748 UT WOS:A1992JY74800002 PM 1448895 ER PT J AU ANDERSON, K KING, AMQ LERCH, RA WERTZ, GW AF ANDERSON, K KING, AMQ LERCH, RA WERTZ, GW TI POLYLACTOSAMINOGLYCAN MODIFICATION OF THE RESPIRATORY SYNCYTIAL VIRUS SMALL HYDROPHOBIC (SH) PROTEIN - A CONSERVED FEATURE AMONG HUMAN AND BOVINE RESPIRATORY SYNCYTIAL VIRUSES SO VIROLOGY LA English DT Article ID ASPARAGINE-LINKED OLIGOSACCHARIDES; NUCLEOTIDE-SEQUENCE ANALYSIS; RECOMBINANT VACCINIA VIRUS; LYSOSOMAL MEMBRANE-GLYCOPROTEINS; ANTIGENIC SUBGROUP-A; HAMSTER OVARY CELLS; MESSENGER-RNA; ATTACHMENT GLYCOPROTEIN; EXPRESSION; GENE C1 UNIV ALABAMA,DEPT MICROBIOL,BIRMINGHAM,AL 35294. AFRC,INST ANIM HLTH,PIRBRIGHT LAB,WOKING GU24 0NF,SURREY,ENGLAND. RP ANDERSON, K (reprint author), USA,MED RES INST INFECT DIS,FT DETRICK,FREDERICK,MD 21702, USA. FU NHLBI NIH HHS [T32-HL07553]; NIAID NIH HHS [R37 AI12464, AI20181] NR 52 TC 23 Z9 27 U1 0 U2 2 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0042-6822 J9 VIROLOGY JI Virology PD NOV PY 1992 VL 191 IS 1 BP 417 EP 430 DI 10.1016/0042-6822(92)90203-2 PG 14 WC Virology SC Virology GA JT446 UT WOS:A1992JT44600044 PM 1413513 ER PT J AU PEARSON, JG PINKHAM, CFA AF PEARSON, JG PINKHAM, CFA TI STRATEGY FOR DATA-ANALYSIS IN ENVIRONMENTAL SURVEYS EMPHASIZING THE INDEX OF BIOTIC SIMILARITY AND BIOSIM1 SO WATER ENVIRONMENT RESEARCH LA English DT Article DE ANALYSIS; BIOTIC; COMMUNITIES; INDEX; SURVEYS ID DIVERSITY AB The index of biotic similarity (B) was intended to help pollution biologists reach a better understanding of their data. However, problems that surfaced after its publication in 1976 indicated that improvements would be helpful. This paper presents these improvements. The approach has been threefold: first, we introduce a computer program, BIOSIM1, that automates many of the procedures that would otherwise have to be done laboriously by hand; second, we discuss a thorough and ecologically sound strategy for analyzing data using BIOSIM1; and third, we present ways to use the various options inherent in the first two steps and discuss the ecological conditions under which each option is appropriate. C1 USA,DIV ENVIRONM & LIFE SCI,DUGWAY PROVING GROUND,UT. RP PEARSON, JG (reprint author), US EPA,ENVIRONM MONITORING SYST LAB,POB 93478,LAS VEGAS,NV 89193, USA. NR 27 TC 2 Z9 2 U1 0 U2 0 PU WATER ENVIRONMENT FEDERATION PI ALEXANDRIA PA 601 WYTHE ST, ALEXANDRIA, VA 22314-1994 SN 1061-4303 J9 WATER ENVIRON RES JI Water Environ. Res. PD NOV-DEC PY 1992 VL 64 IS 7 BP 901 EP 909 PG 9 WC Engineering, Environmental; Environmental Sciences; Limnology; Water Resources SC Engineering; Environmental Sciences & Ecology; Marine & Freshwater Biology; Water Resources GA KB949 UT WOS:A1992KB94900008 ER PT J AU ARCONE, SA CHACHO, EF DELANEY, AJ AF ARCONE, SA CHACHO, EF DELANEY, AJ TI SHORT-PULSE RADAR DETECTION OF GROUNDWATER IN THE SAGAVANIRKTOK RIVER FLOODPLAIN IN EARLY SPRING SO WATER RESOURCES RESEARCH LA English DT Article ID MOUNDS; ROCK AB Short-pulse radar operating in the UHF band was used to search for unfrozen water beneath ice blisters and within the gravels of the Sagavanirktok River floodplain near Prudhoe Bay, Alaska. The investigations were carried out in early April 1991, when daily mean air temperatures still were below -20-degrees-C. The radar pulse spectrum was centered near 400 MHz and the radar time range was set to cover about 10 m depth. The flat, snow-covered surface allowed good antenna-ground coupling, and the ice and gravels provided a low-loss propagation medium that allowed detail of the gravel structure to be seen in the data. Grids of several traverses were profiled at three sites, all within an area of about 0.5 km2 .Unfrozen water was inferred from the strength and polarization of the radar reflections. One site contained a large icing blister beneath which an extensive reservoir was mapped and seen to extend several tens of meters beyond the mound. Data from two other sites indicated taliks 5-7 m deep near a frozen mound and within the gravels. One of the profiles extended 700 m across the floodplain and revealed other high-reflectivity targets, which were presumed to be water, within about 7 m of the surface; a deeper sounding confirmed this depth limit. It is concluded that taliks exist in the floodplain throughout the winter and are a probable source for the numerous icing mounds seen along most Arctic rivers east of Prudhoe Bay. RP ARCONE, SA (reprint author), USA,COLD REG RES & ENGN LAB,HANOVER,NH 03755, USA. NR 36 TC 21 Z9 21 U1 1 U2 1 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 SN 0043-1397 J9 WATER RESOUR RES JI Water Resour. Res. PD NOV PY 1992 VL 28 IS 11 BP 2925 EP 2936 DI 10.1029/92WR01308 PG 12 WC Environmental Sciences; Limnology; Water Resources SC Environmental Sciences & Ecology; Marine & Freshwater Biology; Water Resources GA JW482 UT WOS:A1992JW48200005 ER PT J AU MARKS, D DOZIER, J DAVIS, RE AF MARKS, D DOZIER, J DAVIS, RE TI CLIMATE AND ENERGY EXCHANGE AT THE SNOW SURFACE IN THE ALPINE REGION OF THE SIERRA-NEVADA .1. METROLOGICAL MEASUREMENTS AND MONITORING SO WATER RESOURCES RESEARCH LA English DT Article ID ACCURACY AB A detailed evaluation of climate conditions in a small alpine watershed, typical of much of the southern Sierra Nevada, is presented for the 1986 water year. Measurements of snowfall, meteorological and snow cover conditions, and snow cover ablation are used to characterize the climate at four locations in the watershed during that snow season. Data from these locations are then combined into two representative sites for the watershed. Measurement approaches and methodologies and the effectiveness of instrumentation used in the study are discussed, and an estimate of the uncertainty of the monitored meteorological parameters is made. The data are integrated into a continuous hourly time series of solar and thermal radiation, air, snow and soil temperature, humidity, and wind at the two representative sites in this remote alpine watershed for an entire snow season. Snow deposition and snow cover depth and density are measured manually at regular intervals throughout the snow season. While problems were encountered monitoring air and snow surface temperature, humidity, and wind, because of the extreme conditions which are likely to occur in an alpine environment, radiation is easily monitored, and the estimated uncertainty of all measured parameters was acceptably low. This effort was required,to develop a high quality time series of integrated climate data to evaluate the components of the energy balance of the snow cover during both deposition and ablation conditions. C1 UNIV CALIF SANTA BARBARA,CTR REMOTE SENSING & ENVIRONM OPT,SANTA BARBARA,CA 93106. USA,CORPS ENGINEERS,COLD REG RES & ENGN LAB,HANOVER,NH 03755. RP MARKS, D (reprint author), US EPA,MANTECH ENVIRONM TECHNOL INC,ENVIRONM RES LAB,200 SW 35TH ST,CORVALLIS,OR 97330, USA. RI Dozier, Jeff/B-7364-2009 OI Dozier, Jeff/0000-0001-8542-431X NR 43 TC 61 Z9 62 U1 0 U2 15 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 SN 0043-1397 J9 WATER RESOUR RES JI Water Resour. Res. PD NOV PY 1992 VL 28 IS 11 BP 3029 EP 3042 DI 10.1029/92WR01482 PG 14 WC Environmental Sciences; Limnology; Water Resources SC Environmental Sciences & Ecology; Marine & Freshwater Biology; Water Resources GA JW482 UT WOS:A1992JW48200016 ER PT J AU RUE, LW CIOFFI, WG RUSH, R MCMANUS, WF PRUITT, BA AF RUE, LW CIOFFI, WG RUSH, R MCMANUS, WF PRUITT, BA TI THROMBOEMBOLIC COMPLICATIONS IN THERMALLY INJURED PATIENTS SO WORLD JOURNAL OF SURGERY LA English DT Article ID VENOUS THROMBOSIS; HEPARIN; THROMBOCYTOPENIA AB The frequency of thromboembolic complications in burn patients has been estimated to range from 0.4% to 7%. The clinical significance of these events is often debated and has prompted some centers to adopt the routine prophylactic use of low dose heparin prophylaxis. A 10 year review of 2,103 burn patients treated at this institution was undertaken. Twenty-five (1.2%) patients, with a mean age of 40.0 years and an average burn size of 49.3% total body surface area (TBSA), were identified as having significant pulmonary thromboembolism (PTE). In only 3 (0.14%) patients was the thromboembolism considered to be a cause of death. Nineteen (0.9%) patients, with an average age of 36.7 years and a mean burn size of 48.3% TBSA, developed clinically evident deep venous thrombosis (DVT); however, in only 1 (0.05%) patient did the disease progress to fatal PTE. A review of the literature reveals a 0.6% to 5% incidence of complications related to low dose heparin therapy which includes bleeding, thrombocytopenia, and arterial thrombosis. We feel that the infrequency of clinically significant PTE and DVT in burn patients and the comparable or greater rate of complications associated with heparin prophylaxis mitigate against the routine use of low dose heparin therapy except in patients at high risk for these events. RP RUE, LW (reprint author), USA,INST SURG RES,LIB BRANCH,BLDG 2653,FT SAM HOUSTON,TX 78234, USA. NR 16 TC 39 Z9 40 U1 0 U2 0 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0364-2313 J9 WORLD J SURG JI World J.Surg. PD NOV-DEC PY 1992 VL 16 IS 6 BP 1151 EP 1155 PG 5 WC Surgery SC Surgery GA JY750 UT WOS:A1992JY75000022 PM 1455888 ER PT J AU NEWMAN, AH BEVAN, K BOWERY, N TORTELLA, FC AF NEWMAN, AH BEVAN, K BOWERY, N TORTELLA, FC TI SYNTHESIS AND EVALUATION OF 3-SUBSTITUTED 17-METHYLMORPHINAN ANALOGS AS POTENTIAL ANTICONVULSANT AGENTS SO JOURNAL OF MEDICINAL CHEMISTRY LA English DT Article ID GUINEA-PIG BRAIN; DEXTROMETHORPHAN BINDING-SITES; METHYL-D-ASPARTATE; PHENCYCLIDINE-LIKE DRUGS; RECEPTOR COMPLEX; H-3 GLYCINE; RAT-BRAIN; DEXTRORPHAN; METABOLISM; ACID AB Dextromethorphan (1, (+)-3-methoxy-17-methylmorphinan) demonstrates anticonvulsant activity in a variety of in vitro and in vivo models of convulsive action. It is well known that 1 is metabolized to its phenolic derivative dextrorphan (2) and this metabolite is also a potent anticonvulsant. A series of (+)-3-substituted-17-methylmorphinans, which are structurally similar to 1 but are either not expected to be metabolized to 2 or might do so at a reduced rate, as compared to 1, were prepared. Three analogs, 5 ((+)-3-amino-17-methylmorphinan), 14 ((+)-3-ethoxy-17-methylmorphinan), and 15 ((+)-3-(2-propoxy)-17-methylmorphinan) were found to possess potent anticonvulsant activity with full efficacy (ED50 25, 5.6, and 3.9 mg/kg, sc, respectively) in the rat supramaximal electroshock (MES) test. Binding potencies of these compounds to receptor sites labeled with [H-3]dextromethorphan ([H-1]1), in rat brain and guinea pig brain subcellular fractions, and [H-3]thienylcyclohexylpiperidine (TCP) and [H-3]glycine in rat brain, were determined. Most of the analogs displaced [H-3]1 from its binding sites, with compounds 14 (IC50 0.42 muM) and 15 (IC50 0.88 muM) having equivalent potencies to 1 (IC50 0.59 muM), in rat brain, and no appreciable activity at the [H-3]TCP or [3H]glycine-labeled sites. Compound 5 did not bind with appreciable activity to the [H-3]1 site, in rat brain, but did bind to the [H-3]TCP site with lower potency than the parent 1 (IC50 7.8 and 2.0 muM, respectively). The mechanism of anticonvulsant action of these agents is not clear although it appears that interaction at the [H-3]1 sites may be involved. C1 WALTER REED ARMY INST RES,DEPT APPL BIOCHEM,WASHINGTON,DC 20307. UNIV LONDON,SCH PHARM,DEPT PHARMACOL,LONDON WC1N 1AX,ENGLAND. WALTER REED ARMY INST RES,NEUROPHARMACOL BRANCH,WASHINGTON,DC 20307. RP NEWMAN, AH (reprint author), NIDA,ADDICT RES CTR,PSYCHOBIOL LAB,DRUG DEV GRP,POB 5180,BALTIMORE,MD 21224, USA. NR 52 TC 21 Z9 21 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0022-2623 J9 J MED CHEM JI J. Med. Chem. PD OCT 30 PY 1992 VL 35 IS 22 BP 4135 EP 4142 DI 10.1021/jm00100a019 PG 8 WC Chemistry, Medicinal SC Pharmacology & Pharmacy GA JW906 UT WOS:A1992JW90600019 PM 1433216 ER PT J AU BERRY, AK AMIRTHARAJ, PM DU, JT BOONE, JL MARTIN, DD AF BERRY, AK AMIRTHARAJ, PM DU, JT BOONE, JL MARTIN, DD TI PHOTOLUMINESCENCE AND RAMAN STUDIES OF CDS FILMS GROWN BY METAL ORGANIC-CHEMICAL VAPOR-DEPOSITION ON SI(111) SUBSTRATES SO THIN SOLID FILMS LA English DT Article ID SOLAR-CELL; CDTE; EPITAXY AB CdS epitaxial films grown using metal-organic chemical vapor deposition on Si{111} substrates at growth temperatures ranging from 270 to 325-degrees-C have been characterized using photoluminescence and Raman spectroscopy. Out of all the samples the best optical behavior is obtained from that grown at the lowest temperature. Samples grown at the lowest temperature exhibited increased intensity of the bound excitonic peaks and reduced emission at the defect-related luminescence region. The Raman spectra were compatible with the film surface being normal to the c axis, indicating a preferred growth orientation. C1 USA,CTR NIGHT VIS & ELECTROOPT,FT BELVOIR,VA 22060. UNIV MISSOURI,DEPT ELECT ENGN,ROLLA,MO 65401. RP BERRY, AK (reprint author), GEORGE MASON UNIV,DEPT ELECT & COMP ENGN,FAIRFAX,VA 22030, USA. NR 18 TC 14 Z9 15 U1 0 U2 9 PU ELSEVIER SCIENCE SA LAUSANNE PI LAUSANNE 1 PA PO BOX 564, 1001 LAUSANNE 1, SWITZERLAND SN 0040-6090 J9 THIN SOLID FILMS JI Thin Solid Films PD OCT 30 PY 1992 VL 219 IS 1-2 BP 153 EP 156 DI 10.1016/0040-6090(92)90736-U PG 4 WC Materials Science, Multidisciplinary; Materials Science, Coatings & Films; Physics, Applied; Physics, Condensed Matter SC Materials Science; Physics GA JZ124 UT WOS:A1992JZ12400022 ER PT J AU BEHRENS, R BULUSU, S AF BEHRENS, R BULUSU, S TI THERMAL-DECOMPOSITION OF ENERGETIC MATERIALS .3. TEMPORAL BEHAVIORS OF THE RATES OF FORMATION OF THE GASEOUS PYROLYSIS PRODUCTS FROM CONDENSED-PHASE DECOMPOSITION OF 1,3,5-TRINITROHEXAHYDRO-S-TRIAZINE SO JOURNAL OF PHYSICAL CHEMISTRY LA English DT Article ID BEAM MASS-SPECTROMETRY; 1,3,5 TRIAZINE RDX; OCTAHYDRO-1,3,5,7-TETRANITRO-1,3,5,7-TETRAZOCINE HMX; MELTING POINT; TEMPERATURES; CHEMISTRY; PRESSURE; FTIR AB Through the use of simultaneous thermogravimetry modulated beam mass spectrometry (STMBMS) measurements, time-of-flight (TOF) velocity-spectra analysis, and H-2, C-13, N-15, and O-18 labeled analogues of 1,3,5-trinitrohexahydro-s-triazine (RDX), the thermal decomposition products of RDX have been identified as H2O, HCN, CO, CH2O, NO, N2O, NH2CHO, NO2, HONO, (CH3)NHCHO, oxy-s-triazine (OST), and 1-nitroso-3,5-dinitrohexahydro-s-triazine (ONDNTA) and all of their gas formation rates have been measured as a function of time. From these results the primary reaction pathways that control the decomposition of RDX in both the solid and liquid phases have been discovered. Four primary reaction pathways control the decomposition of RDX in the liquid phase between 200 and 215-degrees-C. Two pathways are first-order reactions solely in RDX. One produces predominantly OST, NO, and H2O and accounts for approximately 30% of the decomposed RDX, and the other produces predominantly N2O and CH2O with smaller amounts of NO2, CO, and NH2CHO and accounts for 10% of the decomposed RDX. The third pathway consists of formation of ONDNTA by reaction between NO and RDX, followed by the decomposition of ONDNTA to predominantly CH2O and N2O. The fourth reaction pathway consists of decomposition of RDX through reaction with a catalyst that is formed from the decomposition products of previously decomposed RDX. The third and fourth reaction channels each account for approximately 30% of the decomposed RDX. Experiments with solid-phase RDX have shown that its decomposition rate is very much slower than that of liquid-phase RDX. ONDNTA is the only product that appears to be formed during the early stages of the decomposition of RDX in the solid phase. As the solid-phase decomposition progresses, N2O and lesser amounts of CH2O start to evolve and their rates of evolution increase until products associated with the liquid-phase RDX decomposition appear and the rates of gas formation of all products rapidly increase. This behavior strongly suggests that the decomposition of solid RDX occurs through formation of ONDNTA within the lattice, the subsequent decomposition of it within the lattice to N2O and CH2O, followed by the dispersion of CH2O in the RDX, leading to its eventual liquefaction and the onset of the liquid-phase decomposition reactions. C1 USA,ARMAMENT RES,CTR DEV & ENGN,DIV ENERGET MAT,DOVER,NJ 07801. RP BEHRENS, R (reprint author), SANDIA NATL LABS,COMBUST RES FACIL,LIVERMORE,CA 94551, USA. NR 41 TC 86 Z9 86 U1 3 U2 7 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0022-3654 J9 J PHYS CHEM-US JI J. Phys. Chem. PD OCT 29 PY 1992 VL 96 IS 22 BP 8877 EP 8891 DI 10.1021/j100201a036 PG 15 WC Chemistry, Physical SC Chemistry GA JW464 UT WOS:A1992JW46400036 ER PT J AU BEHRENS, R BULUSU, S AF BEHRENS, R BULUSU, S TI THERMAL-DECOMPOSITION OF ENERGETIC MATERIALS .4. DEUTERIUM-ISOTOPE EFFECTS AND ISOTOPIC SCRAMBLING (H/D, C-13/O-18, N-14/N-15) IN CONDENSED-PHASE DECOMPOSITION OF 1,3,5-TRINITROHEXAHYDRO-S-TRIAZINE SO JOURNAL OF PHYSICAL CHEMISTRY LA English DT Article ID TANDEM MASS-SPECTROMETRY; OCTAHYDRO-1,3,5,7-TETRANITRO-1,3,5,7-TETRAZOCINE HMX; PYROLYSIS PRODUCTS; 1,3,5,7-TETRANITRO-1,3,5,7-TETRAAZACYCLOOCTANE; RATES; RDX AB The inter- vs intramolecular origin of the products formed in the thermal decomposition of 1,3,5-trinitrohexahydro-s-triazine (RDX) has been traced by isotopic crossover experiments using mixtures of differently labeled analogues of RDX. The isotopic analogues of RDX used in the experiments include H-2, C-13, N-15, and O-18. The fraction of isotopic scrambling and the extent of the deuterium kinetic isotope effect (DKIE) are reported for the different thermal decomposition products. Isotopic scrambling is not observed for the N-N bond in N2O and only in small amounts (7%) in the C-H bonds in CH2O, consistent with a mechanism of their formation through methylene nitramine precursors. A product, oxy-s-triazine (OST, C3H3N3O) does not undergo isotopic scrambling in H/D, N-14/N-15, or C-13/O-18 experiments, and its rate of formation exhibits a DKIE of 1.5. These results are consistent with the formation of OST via unimolecular decomposition of RDX. Another product, 1-nitroso-3,5-dinitrohexahydro-s-triazine (ONDNTA, C3H6N6O5) is found to be formed with complete scrambling of the N-NO bond, suggesting an N-N bond cleavage and a radical recombination process in its formation. One of the hydrogen containing products, H2O, exhibits a DKIE of 1.5 +/- 0.1. In contrast, CH2O and ONDNTA have DKIEs of 1.05 +/- 0.1 and 1.05 +/- 0.2, respectively, indicating that hydrogen transfer is not involved in the rate-limiting step of the reaction pathway leading to the formation of these products. C1 USA,ARMAMENT RES,DEV CTR & ENGN,DIV ENERGET MAT,DOVER,NJ 07801. RP BEHRENS, R (reprint author), SANDIA NATL LABS,COMBUST RES FACIL,LIVERMORE,CA 94551, USA. NR 28 TC 60 Z9 60 U1 4 U2 6 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0022-3654 J9 J PHYS CHEM-US JI J. Phys. Chem. PD OCT 29 PY 1992 VL 96 IS 22 BP 8891 EP 8897 DI 10.1021/j100201a037 PG 7 WC Chemistry, Physical SC Chemistry GA JW464 UT WOS:A1992JW46400037 ER PT J AU GRANT, E BEELER, TJ TAYLOR, KMP GABLE, K ROSEMAN, MA AF GRANT, E BEELER, TJ TAYLOR, KMP GABLE, K ROSEMAN, MA TI MECHANISM OF MAGAININ-2A INDUCED PERMEABILIZATION OF PHOSPHOLIPID-VESICLES SO BIOCHEMISTRY LA English DT Article ID REVERSE-PHASE EVAPORATION; ANTIMICROBIAL ACTIVITY; OCTYL GLUCOSIDE; SODIUM CHOLATE; XENOPUS SKIN; MEMBRANE; PEPTIDES; BILAYERS; ANALOGS; BINDING AB The magainins, peptide antibiotics secreted by the frog Xenopus laevis, have previously been shown to permeabilize phospholipid vesicles. To elucidate the mechanism of permeabilization, we have conducted detailed kinetic studies of magainin 2 amide (mgn2a)-induced release of 6-carboxyfluorescein from vesicles of phosphatidylserine. The results show that dye release occurs in (at least) two stages-an initial rapid phase, with t1/2 almost-equal-to 3 s, followed by a much slower phase that approaches zero leakage rate before all the dye is released. Light-scattering studies showed that mgn2a does not cause gross changes in vesicle structure. The peptide was found to rapidly equilibrate between vesicles; this was demonstrated by determining a binding isotherm for the peptide-lipid interaction, and by showing that addition of unloaded vesicles rapidly quenches peptide-induced leakage from loaded vesicles. Transient dye release in the presence of an equilibrating peptide can be explained in two ways: (1) the peptide exists only transiently in an active form; (2) the vesicles are only transiently leaky. Preincubation of mgn2a at assay concentrations in buffer alone or with unloaded vesicles did not inactivate the peptide. Therefore, rapid leakage is probably due to transient destabilization of the vesicle upon addition of mgn2a. C1 UNIFORMED SERV UNIV HLTH SCI,DEPT BIOCHEM,4301 JONES BRIDGE RD,BETHESDA,MD 20814. BROOKE ARMY MED CTR,DIV CLIN INVEST,FT SAM HOUSTON,TX 78234. NR 26 TC 82 Z9 82 U1 0 U2 3 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0006-2960 J9 BIOCHEMISTRY-US JI Biochemistry PD OCT 20 PY 1992 VL 31 IS 41 BP 9912 EP 9918 DI 10.1021/bi00156a008 PG 7 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA JU511 UT WOS:A1992JU51100008 PM 1390773 ER PT J AU NAGY, EV BURCH, HB MAHONEY, K LUKES, YG MORRIS, JC BURMAN, KD AF NAGY, EV BURCH, HB MAHONEY, K LUKES, YG MORRIS, JC BURMAN, KD TI GRAVES IGG RECOGNIZES LINEAR EPITOPES IN THE HUMAN THYROTROPIN RECEPTOR SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS LA English DT Article ID RABBIT ANTIBODIES; PROTEIN; IDENTIFICATION; PEPTIDES C1 WALTER REED ARMY MED CTR,KYLE METAB UNIT,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. MAYO CLIN & MAYO FDN,DEPT INTERNAL MED,ROCHESTER,MN 55905. MAYO CLIN & MAYO GRAD SCH MED,ROCHESTER,MN 55905. RP NAGY, EV (reprint author), WALTER REED ARMY MED CTR,ENDOCRINE METAB SERV,WASHINGTON,DC 20307, USA. FU FIC NIH HHS [1 FO5 TWO4412-02] NR 13 TC 26 Z9 27 U1 0 U2 1 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0006-291X J9 BIOCHEM BIOPH RES CO JI Biochem. Biophys. Res. Commun. PD OCT 15 PY 1992 VL 188 IS 1 BP 28 EP 33 DI 10.1016/0006-291X(92)92345-X PG 6 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA JU247 UT WOS:A1992JU24700005 PM 1384483 ER PT J AU KORNBLITH, AB ANDERSON, J CELLA, DF TROSS, S ZUCKERMAN, E CHERIN, E HENDERSON, E WEISS, RB COOPER, MR SILVER, RT LEONE, L CANELLOS, GP GOTTLIEB, A HOLLAND, JC AF KORNBLITH, AB ANDERSON, J CELLA, DF TROSS, S ZUCKERMAN, E CHERIN, E HENDERSON, E WEISS, RB COOPER, MR SILVER, RT LEONE, L CANELLOS, GP GOTTLIEB, A HOLLAND, JC TI HODGKIN DISEASE SURVIVORS AT INCREASED RISK FOR PROBLEMS IN PSYCHOSOCIAL ADAPTATION SO CANCER LA English DT Article DE HODGKIN DISEASE; CANCER SURVIVORS; PSYCHOSOCIAL ADAPTATION ID CANCER SURVIVORS; ILLNESS; CHEMOTHERAPY; CHILDHOOD; QUALITY; SCALE AB Background. The long-term psychosocial adaptations of 273 survivors of advanced Hodgkin disease were assessed to determine the nature and extent of problems experienced and to identify those at high risk for maladaptation. Methods. Hodgkin disease survivors were identified who initially had been treated in clinical trials within the Cancer and Leukemia Group B from 1966 to 1986, were currently disease free, and had completed treatment for a minimum of 1 year. All survivors had advanced Hodgkin disease (with disease diagnosed at a mean age of 28 years). Survivors were at a mean age of 37 years at the time of interview (6.3 years after treatment completion), and 60% were male. Survivors were interviewed over the telephone 7-10 days after questionnaires were mailed to them concerning their psychological, social, vocational, and sexual functioning. Results. Psychological distress was found to be elevated by one standard deviation (SD) above that of healthy subjects on the Brief Symptom Inventory, and 22% met the criterion suggested for a psychiatric diagnosis. In addition, the following problems were reported by survivors to be a consequence of having had Hodgkin disease: denial of life (31%) and health (22%) insurance, sexual problems (37%), conditioned nausea in response to reminders of chemotherapy (39%), and a negative socioeconomic effect (36%). Survivors found to be at high risk for maladaptation were: men earning less than $15,000 per year or who were currently unemployed; unmarried individuals; those with serious illnesses since treatment completion; and those who were less educated. Conclusions. These findings suggest that including a routine assessment of these factors would help to target survivors in need of additional evaluation and treatment. C1 UNIV NEBRASKA,MED CTR,CTR BIOSTAT,CANC & LEUKEMIA GRP B,OMAHA,NE 68105. RUSH PRESBYTERIAN ST LUKES MED CTR,CHICAGO,IL 60612. UNIV MED & DENT NEW JERSEY,NEWARK,NJ 07103. WAKE FOREST UNIV,BOWMAN GRAY SCH MED,WINSTON SALEM,NC 27103. NEW YORK HOSP,NEW YORK,NY 10021. RHODE ISL HOSP,PROVIDENCE,RI 02902. HARVARD UNIV,SCH MED,DANA FARBER CANC INST,BOSTON,MA 02115. NEW YORK STATE DEPT HLTH,ROSWELL PK MEM INST,BUFFALO,NY 14263. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. SUNY HLTH SCI CTR,SYRACUSE,NY. RP KORNBLITH, AB (reprint author), MEM SLOAN KETTERING CANC CTR,PSYCHIAT SERV,1275 YORK AVE,NEW YORK,NY 10021, USA. FU NCI NIH HHS [CA 32291, CA 03927, CA31946] NR 41 TC 108 Z9 108 U1 3 U2 4 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0008-543X J9 CANCER JI Cancer PD OCT 15 PY 1992 VL 70 IS 8 BP 2214 EP 2224 DI 10.1002/1097-0142(19921015)70:8<2214::AID-CNCR2820700833>3.0.CO;2-X PG 11 WC Oncology SC Oncology GA JT859 UT WOS:A1992JT85900032 PM 1394054 ER PT J AU TAKAGI, S AF TAKAGI, S TI CHEMICAL-POTENTIAL OF A LAYER OF WATER ADSORBED ON A SOLID-SURFACE SO JOURNAL OF COLLOID AND INTERFACE SCIENCE LA English DT Article ID ICE C1 USA,COLD REG RES & ENGN LAB,HANOVER,NH 03755. NR 16 TC 2 Z9 2 U1 1 U2 2 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0021-9797 J9 J COLLOID INTERF SCI JI J. Colloid Interface Sci. PD OCT 15 PY 1992 VL 153 IS 2 BP 521 EP 528 DI 10.1016/0021-9797(92)90342-J PG 8 WC Chemistry, Physical SC Chemistry GA JT521 UT WOS:A1992JT52100019 ER PT J AU DURIG, JR LIU, J LITTLE, TS KALASINSKY, VF AF DURIG, JR LIU, J LITTLE, TS KALASINSKY, VF TI CONFORMATIONAL-ANALYSIS, BARRIERS TO INTERNAL-ROTATION, VIBRATIONAL ASSIGNMENT, AND ABINITIO CALCULATIONS OF 1,2-DIFLUOROETHANE SO JOURNAL OF PHYSICAL CHEMISTRY LA English DT Article ID ELECTRON-DIFFRACTION; MOLECULAR-STRUCTURE; MICROWAVE-SPECTRUM; CONFORMERS; MATRICES; ENERGIES; ETHANES; ETHENES AB The far infrared (50-370-cm-1) and low frequency Raman (70-300-cm-1) spectra of gaseous 1,2-difluoroethane have been recorded. The fundamental asymmetric torsional frequencies of the more stable gauche (two fluorine atoms oriented gauche to one another) and the high energy trans conformations have been observed in the far infrared spectrum of the gas at 147.0 and 116.7 cm-1, respectively. For the trans conformer, four Q-branches arising from transitions between excited torsional vibrational states have also been observed. With use of these data, along with the enthalpy difference and the gauche torsional dihedral angle, the potential function governing internal rotation about the C-C bond has been determined with the following potential coefficients: V1 = 557 +/- 14 cm-1, V2 = -846 +/- 12 cm-1, V3 = 1163 +/- 4 cm-1, V4 = 51 +/- 4 cm-1, and V6 = -23 +/- 2 cm-1. This potential is consistent with an energy difference of 280 +/- 30 cm-1 (0.80 +/- 0.09 kcal/mol), a gauche dihedral angle of 71.0-degrees, and tram to gauche, gauche to gauche, and gauche to trans barriers of 741,2000, and 1021 cm-1, respectively. The conformational stability, barriers to internal rotation, and vibrational frequencies are compared to those obtained from ab initio calculations utilizing the RHF/6-311++G** basis set and to the corresponding results previously obtained for some similar molecules. C1 WALTER REED ARMY MED CTR,ARMED FORCES INST PATHOL,WASHINGTON,DC 20307. RP DURIG, JR (reprint author), UNIV S CAROLINA,DEPT CHEM & BIOCHEM,COLUMBIA,SC 29208, USA. NR 33 TC 107 Z9 107 U1 2 U2 11 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0022-3654 J9 J PHYS CHEM-US JI J. Phys. Chem. PD OCT 15 PY 1992 VL 96 IS 21 BP 8224 EP 8233 DI 10.1021/j100200a006 PG 10 WC Chemistry, Physical SC Chemistry GA JU555 UT WOS:A1992JU55500006 ER PT J AU DUDLEY, M TOLIS, G GORDONSMITH, D FAZI, C AF DUDLEY, M TOLIS, G GORDONSMITH, D FAZI, C TI A NEW DIAGNOSTIC-TOOL FOR THE NONDESTRUCTIVE CHARACTERIZATION OF DAMAGE ACCOMPANYING THE ELECTROMAGNETIC BREAKDOWN OF EPITAXIAL SILICON P-N-JUNCTIONS SO MATERIALS SCIENCE AND ENGINEERING B-SOLID STATE MATERIALS FOR ADVANCED TECHNOLOGY LA English DT Article AB Synchrotron white-beam X-ray diffraction topography, in both transmission and grazing Bragg-Laue geometries, has been applied to the investigation of the damage induced during the breakdown of p-n junctions on silicon. The technique, which is highly strain sensitive, can yield information on both the lateral and the depth distributions of distortion in the devices in a non-destructive way. Both transmission and grazing Bragg-Laue images reveal clear differences in the extent and distribution of crystallographic damage accompanying the forward- and reverse-bias breakdown phenomena. Variable-penetration-depth grazing Bragg-Laue imaging has revealed variations in the distribution of damage as a function of depth in both the forward- and the reverse-bias case. The results indicate that these techniques constitute unique diagnostic tools for the investigation of these and other related phenomena. Comparison of results with optical microscopy studies indicates that the X-ray techniques yield subsurface information not revealed by optical techniques. C1 UNIV WARWICK,DEPT SYNTHET CHEM,MAT SCI LAB,COVENTRY CV4 7AL,W MIDLANDS,ENGLAND. USA,HARRY DIAMOND LABS,ADELPHI,MD 20783. RP DUDLEY, M (reprint author), SUNY STONY BROOK,DEPT MAT SCI & ENGN,STONY BROOK,NY 11794, USA. NR 8 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE SA LAUSANNE PI LAUSANNE 1 PA PO BOX 564, 1001 LAUSANNE 1, SWITZERLAND SN 0921-5107 J9 MAT SCI ENG B-SOLID JI Mater. Sci. Eng. B-Solid State Mater. Adv. Technol. PD OCT 15 PY 1992 VL 15 IS 1 BP 56 EP 62 DI 10.1016/0921-5107(92)90030-D PG 7 WC Materials Science, Multidisciplinary; Physics, Condensed Matter SC Materials Science; Physics GA JV826 UT WOS:A1992JV82600011 ER PT J AU KWOK, AS SERPENGUZEL, A HSIEH, WF CHANG, RK GILLESPIE, JB AF KWOK, AS SERPENGUZEL, A HSIEH, WF CHANG, RK GILLESPIE, JB TI 2-PHOTON-PUMPED LASING IN MICRODROPLETS SO OPTICS LETTERS LA English DT Article ID LASER-EMISSION; DROPLETS; WAVELENGTHS AB Lasing is observed in laser-dye-doped ethanol droplets after two-photon absorption by the dye molecules. The two-photon-pumped lasing emission by the droplets is at a higher frequency than the input laser. Competitive nonlinear-optical effects that occur at high input-laser intensity are discussed. C1 CTR LASER DIAGNOST,NEW HAVEN,CT 06520. WHITE SANDS MISSILES RANGE,ATMOSPHER SCI LAB,WHITE SANDS MISSILE RANGE,NM 88002. RP KWOK, AS (reprint author), DEPT APPL PHYS,POB 2157 YALE STN,NEW HAVEN,CT 06520, USA. NR 15 TC 50 Z9 52 U1 0 U2 5 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0146-9592 J9 OPT LETT JI Opt. Lett. PD OCT 15 PY 1992 VL 17 IS 20 BP 1435 EP 1437 DI 10.1364/OL.17.001435 PG 3 WC Optics SC Optics GA JT568 UT WOS:A1992JT56800012 PM 19798205 ER PT J AU HANSEN, U YUEN, DA MALEVSKY, AV AF HANSEN, U YUEN, DA MALEVSKY, AV TI COMPARISON OF STEADY-STATE AND STRONGLY CHAOTIC THERMAL-CONVECTION AT HIGH RAYLEIGH NUMBER SO PHYSICAL REVIEW A LA English DT Article ID INFINITE PRANDTL NUMBER; TURBULENT CONVECTION; MANTLE CONVECTION; BENARD CONVECTION; HARD TURBULENCE; BOUNDARY-LAYERS; HEAT-TRANSPORT; EARTHS MANTLE; HELIUM-GAS; FLOWS AB Steady-state and time-dependent two-dimensional thermal convection in a Boussinesq, infinite-Prandtl-number fluid with stress-free boundaries has been investigated. Two independent numerical methods have been employed to calculate the evolution of convective flows in a rectangular box with aspect ratio lambda = 1.8 in a Rayleigh-number (Ra) range of 10(6) < Ra < 10(9). With increasing Ra, greater than 10(7), the flow reveals the presence of disconnected thermals, rather than connected plumes, driven by a persistent large-scale circulation. Such features have also been reported from laboratory convection experiments in the regime of hard turbulence. Extensive calculations were performed (up to 140 overturns) in order to reach the statistically stationary regime for strongly chaotic flows. A Gaussian distribution with a mean value Nu(t) was derived from the time history of the Nusselt (Nu) numbers. The value of Nu(t) can be directly obtained by solving the steady-state equations via an iteration procedure. Thus the stationary flow obtained from the steady-state method resembles the turbulent flow in a statistical sense. Since the iteration procedure is about 10(4) times faster than calculating the full time-dependent evolution, it allows for the systematic investigation of the heat-transfer Nu-Ra relationship and other types of scaling laws. The steady-state and time-dependent experiments indicate that a power-law exponent of beta=0.315 holds for the Nu-Ra relation for stress-free boundaries in the entire range of Ra. No indication of a jump in the exponent was found in the transition to hard turbulence. C1 UNIV COLOGNE,INST GEOPHYS & METEOROL,W-5000 COLOGNE 41,GERMANY. UNIV MINNESOTA,MINNESOTA SUPERCOMP INST,ARMY HIGH PERFORMANCE COMP RES CTR,MINNEAPOLIS,MN 55414. UNIV MINNESOTA,DEPT GEOL & GEOPHYS,MINNEAPOLIS,MN 55414. NR 45 TC 26 Z9 26 U1 0 U2 8 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1050-2947 J9 PHYS REV A JI Phys. Rev. A PD OCT 15 PY 1992 VL 46 IS 8 BP 4742 EP 4754 DI 10.1103/PhysRevA.46.4742 PG 13 WC Optics; Physics, Atomic, Molecular & Chemical SC Optics; Physics GA JW974 UT WOS:A1992JW97400047 ER PT J AU CHOI, KK TAYSINGLARA, M NEWMAN, PG CHANG, W IAFRATE, GJ AF CHOI, KK TAYSINGLARA, M NEWMAN, PG CHANG, W IAFRATE, GJ TI WAVELENGTH TUNING AND ABSORPTION-LINE SHAPE OF QUANTUM-WELL INFRARED PHOTODETECTORS SO APPLIED PHYSICS LETTERS LA English DT Article AB We have conducted a systematic theoretical and experimental study on wavelength tuning and absorption lineshape of single-bound-state quantum well infrared photodetectors. By computing the oscillator strength using the exact quantum well eigen functions, we show that an intersubband transition is from the ground state to the first resonant state in one extreme when the ground state is totally localized in the well, or to the second miniband in another extreme when the ground state wave function is delocalized. In the intermediate cases, the absorption wavelength is determined by the energy of a final state with which the oscillator strength is maximum. We also calculated the absorption lineshape and show that it depends sensitively on the position of the final state relative to the global band structure of the detector. C1 USA,RES OFF,RES TRIANGLE PK,NC 27709. RP CHOI, KK (reprint author), USA,ELECTR TECHNOL & DEVICES LAB,FT MONMOUTH,NJ 07703, USA. RI Choi, Kwong-Kit/K-9205-2013 NR 9 TC 7 Z9 7 U1 1 U2 1 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD OCT 12 PY 1992 VL 61 IS 15 BP 1781 EP 1783 DI 10.1063/1.108425 PG 3 WC Physics, Applied SC Physics GA JR733 UT WOS:A1992JR73300013 ER PT J AU CHU, B GAO, T LI, YJ WANG, J DESPER, CR BYRNE, CA AF CHU, B GAO, T LI, YJ WANG, J DESPER, CR BYRNE, CA TI MICROPHASE SEPARATION KINETICS IN SEGMENTED POLYURETHANES - EFFECTS OF SOFT SEGMENT LENGTH AND STRUCTURE SO MACROMOLECULES LA English DT Article ID PHASE-SEPARATION; MODEL POLYURETHANES; POLYMER MIXTURES; DYNAMICS; TIME AB Synchrotron small-angle X-ray scattering (SAXS) was used to investigate the microphase structure and microphase separation kinetics of two segmented polyurethanes with 4,4'-diphenylmethyl diisocyanate (MDI) and 1,4'-butanediol (BD) as the hard segment and poly(tetramethylene oxide) (PTMO) and poly(propylene oxide) end-capped with poly(ethylene oxide) (PPO-PEO) (M(n) approximately 2000) as the soft segments. A more complete phase separation was observed in the PTMO based sample although PTMO and PPO-PEO have almost identical solubility parameters. This phase separation behavior could be explained as due partially to a kinetic factor. The microphase separation kinetics from quenching a sample in the melt state to lower annealing temperatures could be described by a relaxation process. A single-relaxation time process was observed for the PTMO based sample. By variation of the soft segment molecular weight from 1000 to 2000, the relaxation time was reduced from approximately 10(3) to 64 s. This behavior strongly supports our argument that in a segmented polyurethane, hard segment mobility, system viscosity, and hard segment interactions are the three controlling factors. In the PPO-PEO-based sample a double-relaxation time process was observed. One of the relaxation times was 54 s while the other secondary process was 1.48 X 10(3) s. C1 SUNY STONY BROOK,DEPT MAT SCI & ENGN,STONY BROOK,NY 11794. USA,MAT TECHNOL LAB,WATERTOWN,MA 02172. RP CHU, B (reprint author), SUNY STONY BROOK,DEPT CHEM,STONY BROOK,NY 11794, USA. RI He, Yong/F-8752-2012 NR 28 TC 120 Z9 122 U1 5 U2 25 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0024-9297 J9 MACROMOLECULES JI Macromolecules PD OCT 12 PY 1992 VL 25 IS 21 BP 5724 EP 5729 DI 10.1021/ma00047a025 PG 6 WC Polymer Science SC Polymer Science GA JT846 UT WOS:A1992JT84600025 ER PT J AU MEYERHOFF, JL CARTER, RE YOURICK, DL SLUSHER, BS COYLE, JT AF MEYERHOFF, JL CARTER, RE YOURICK, DL SLUSHER, BS COYLE, JT TI GENETICALLY EPILEPSY-PRONE RATS HAVE INCREASED BRAIN REGIONAL ACTIVITY OF AN ENZYME WHICH LIBERATES GLUTAMATE FROM N-ACETYL-ASPARTYL-GLUTAMATE SO BRAIN RESEARCH LA English DT Note DE GENETICS; HIPPOCAMPUS; N-ACETYLASPARTYLGLUTAMATE EPILEPSY; GLUTAMATE; N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE; ENZYMATIC; HYDROLYSIS; NAAG; ASPARTATE ID ANTICONVULSANT DRUGS; KINDLED RATS; SEIZURES; ACETYLASPARTYLGLUTAMATE; HYDROLYSIS; ONTOGENY; LESIONS; RELEASE AB N-Acetylated-alpha-linked acidic dipeptidase (NAALADase) is a membrane-bound peptidase which hydrolyzes the endogenous neuropeptide N-acetylaspartylglutamate (NAAG) to N-acetylaspartate (NAA) and the excitatory amino acid, glutamate (Glu). Although there is evidence that NAAG might be a neurotransmitter, this dipeptide could also function as a precursor form of Glu, which is liberated by the dipeptidase. We found that the activity of this NAAG hydrolyzing enzyme in genetically epilepsy-prone rats was 11-26% greater than control in brain regions, including the amygdala, hippocampus and cerebellum, as well as the pyriform, entorhinal and frontal cortices. This is consistent with possible increased availability of Glu in certain CNS synapses in these rats, which are reported to have increased susceptibility to audiogenically, electrically and chemically induced convulsions. C1 JOHNS HOPKINS UNIV,SCH MED,DEPT PHARMACOL & MOLEC SCI,BALTIMORE,MD 21205. ICI AMERICAS,DEPT CNS,WILMINGTON,DE 19897. HARVARD UNIV,SCH MED,DEPT PSYCHIAT,BELMONT,MA 02178. RP MEYERHOFF, JL (reprint author), WALTER REED ARMY MED CTR,DEPT MED NEUROSCI,DIV NEUROPSYCHIAT,WASHINGTON,DC 20307, USA. NR 21 TC 37 Z9 37 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0006-8993 J9 BRAIN RES JI Brain Res. PD OCT 9 PY 1992 VL 593 IS 1 BP 140 EP 143 DI 10.1016/0006-8993(92)91276-K PG 4 WC Neurosciences SC Neurosciences & Neurology GA JU126 UT WOS:A1992JU12600023 PM 1360862 ER PT J AU MCKEE, KT BEREZUK, GP BALADY, MA AF MCKEE, KT BEREZUK, GP BALADY, MA TI MEDICINE AND WAR SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Letter C1 USA,MED MAT DEV ACT,FT DETRICK,MD 21702. USA,MED RES & DEV COMMAND,FT DETRICK,MD 21702. RP MCKEE, KT (reprint author), PREVENT MED SERV,FT BRAGG,NC 28307, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU MASS MEDICAL SOC PI BOSTON PA 10 SHATTUCK, BOSTON, MA 02115 SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD OCT 8 PY 1992 VL 327 IS 15 BP 1097 EP 1097 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA JR321 UT WOS:A1992JR32100013 ER PT J AU URBAN, JJ CRAMER, CJ FAMINI, GR AF URBAN, JJ CRAMER, CJ FAMINI, GR TI A COMPUTATIONAL STUDY OF SOLVENT EFFECTS ON THE CONFORMATION OF DOPAMINE SO JOURNAL OF THE AMERICAN CHEMICAL SOCIETY LA English DT Article ID FREE-ENERGY; MOLECULAR MECHANICS; AQUEOUS-SOLUTION; GAS-PHASE; SOLVATION; MODEL; PARAMETERS; EQUILIBRIA; RECEPTOR; DYNAMICS AB The solution conformation of the neurotransmitter dopamine is investigated with the AM1-SM1 solvation model as implemented in the program AMSOL. AMSOL invokes the AM1 Hamiltonian and evaluates solvent effects based on a continuum model of solvation free energy. In the current work, calculations are performed on the neutral, N-protonated, and OH-deprotonated forms of dopamine with both AM1 (gas phase) and AM1-SM1 (aqueous solution). For both N-protonated and OH-deprotonated dopamine, the gas-phase AM1 calculations predict the anti conformation to be much higher in energy than gauche conformations. AMSOL, however, predicts the anti conformation to be an important contributor to the solution conformer population at neutral pH, in agreement with experimental observations. RP URBAN, JJ (reprint author), USA,CTR CHEM RES DEV & ENGN,SMCCR-RSP-C,ABERDEEN PROVING GROUND,MD 21010, USA. RI Cramer, Christopher/B-6179-2011 OI Cramer, Christopher/0000-0001-5048-1859 NR 41 TC 52 Z9 52 U1 1 U2 6 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0002-7863 J9 J AM CHEM SOC JI J. Am. Chem. Soc. PD OCT 7 PY 1992 VL 114 IS 21 BP 8226 EP 8231 DI 10.1021/ja00047a037 PG 6 WC Chemistry, Multidisciplinary SC Chemistry GA JR863 UT WOS:A1992JR86300037 ER PT J AU BLOEMER, MJ HAUS, JW AF BLOEMER, MJ HAUS, JW TI VERSATILE WAVE-GUIDE POLARIZER INCORPORATING AN ULTRATHIN DISCONTINUOUS SILVER FILM SO APPLIED PHYSICS LETTERS LA English DT Article ID WAVE-GUIDE AB We demonstrate the first transverse magnetic (TM) pass waveguide polarizer suitable for integrated optic or fiber optic geometries. The polarizing properties of waveguides incorporating an ultrathin discontinuous silver film are due to excitation of a localized surface plasmon mode. The polarizers have a large bandwidth ( > 100 nm), high extinction ratios, and do not rely on sensitive phase matching conditions. We illustrate these novel polarizing properties on ion-exchanged planar waveguides overlayed with a 5-nm-mass thick silver film. The measured extinction ratio was 35 dB/mm at 836 nm with 2 dB/mm loss for the TM polarization. The theoretical analysis of the film properties and waveguide propagation losses is compared with the experiments. C1 RENSSELAER POLYTECH INST,DEPT PHYS,TROY,NY 12180. RP BLOEMER, MJ (reprint author), USA,MISSILE COMMAND,AMSMI,RD,WS,CM,REDSTONE ARSENAL,AL 35898, USA. NR 11 TC 28 Z9 29 U1 0 U2 3 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD OCT 5 PY 1992 VL 61 IS 14 BP 1619 EP 1621 DI 10.1063/1.107512 PG 3 WC Physics, Applied SC Physics GA JQ652 UT WOS:A1992JQ65200003 ER PT J AU LEE, J SAFARI, A PFEFFER, RL AF LEE, J SAFARI, A PFEFFER, RL TI GROWTH OF EPITAXIAL PB(ZR,TI)O3 FILMS BY PULSED LASER DEPOSITION SO APPLIED PHYSICS LETTERS LA English DT Article ID TITANATE THIN-FILMS; CERAMICS; BATIO3 AB Lead zirconate titanate (PZT) thin films with a composition near the morphotropic phase boundary have been grown on MgO (100) and Y1Ba2Cu3Ox (YBCO) coated MgO substrates. Substrate temperature and oxygen pressure were varied to achieve ferroelectric films with a perovskite structure. Films grown on MgO had the perovskite structure with an epitaxial relationship with the MgO substrate. On the other hand, films grown on the YBCO/MgO substrate had an oriented structure to the surface normal with a misorientation in the plane parallel to the surface. The measured dielectric constant and loss tangent at 1 kHz were 670 and 0.05, respectively. The remnant polarization and coercive field were 42 muC/CM2 and 53 kV/cm. A large internal bias field ( 12 kV/cm) was observed in the as-deposited state of the undoped PZT films. C1 USA,ELECTR TECHNOL & DEVICES LAB,FT MONMOUTH,NJ 07703. RP LEE, J (reprint author), RUTGERS STATE UNIV,DEPT CERAM SCI & ENGN,PISCATAWAY,NJ 08855, USA. NR 18 TC 57 Z9 59 U1 1 U2 6 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD OCT 5 PY 1992 VL 61 IS 14 BP 1643 EP 1645 DI 10.1063/1.108438 PG 3 WC Physics, Applied SC Physics GA JQ652 UT WOS:A1992JQ65200012 ER PT J AU CRAMER, CJ TRUHLAR, DG AF CRAMER, CJ TRUHLAR, DG TI POLARIZATION OF THE NUCLEIC-ACID BASES IN AQUEOUS-SOLUTION SO CHEMICAL PHYSICS LETTERS LA English DT Article ID MOLECULAR-DYNAMICS SIMULATIONS; REACTION FIELD-THEORY; TAUTOMERIC EQUILIBRIA; ELECTRONIC-PROPERTIES; COMPUTER-SIMULATION; WATER MOLECULE; LIQUID WATER; CHARGE MODEL; SOLVENT; SOLVATION AB We present calculations of the absolute free energy of solvation of five nucleic acid bases and five methylated nucleic acid bases using a recently developed local-field SCF procedure in which the electronic structure and geometry are both optimized in the presence of solvent. The calculated solvation free energies are increased 23%-24% by the aqueous-phase relaxation. C1 UNIV MINNESOTA, DEPT CHEM, MINNEAPOLIS, MN 55455 USA. USA, CTR CHEM RES DEV & ENGN, SMCCR-RSP-C, ABERDEEN PROVING GROUND, MD 21010 USA. UNIV MINNESOTA, INST SUPERCOMP, MINNEAPOLIS, MN 55455 USA. RI Truhlar, Donald/G-7076-2015; Cramer, Christopher/B-6179-2011 OI Truhlar, Donald/0000-0002-7742-7294; Cramer, Christopher/0000-0001-5048-1859 NR 73 TC 72 Z9 72 U1 0 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0009-2614 EI 1873-4448 J9 CHEM PHYS LETT JI Chem. Phys. Lett. PD OCT 2 PY 1992 VL 198 IS 1-2 BP 74 EP 80 DI 10.1016/0009-2614(92)90051-N PG 7 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA JQ116 UT WOS:A1992JQ11600013 ER PT J AU BURLING, FT HALLOWS, WH PHELAN, MJ GABRIELSEN, B GOLDSTEIN, BM AF BURLING, FT HALLOWS, WH PHELAN, MJ GABRIELSEN, B GOLDSTEIN, BM TI STRUCTURES OF THE 4-CYANO AND 4-METHYLAMIDATE ANALOGS OF TIAZOFURIN SO ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE LA English DT Article ID CONTACTS AB 4-Cyanotiazofurin [2-(beta-D-ribofuranosyl)thiazole-4-carbonitrile, (1)], C9H10N2O4S, M(r) = 242.3, monoclinic, P2(1), a = 7.329 (1), b = 8.295 (1), c = 8.697 (1) angstrom, beta = 90.90 (1)-degrees, V = 528.7 (1) angstrom3, Z = 2, D(x) = 1.52 g cm-3, Cu Kalpha, lambda = 1.54178 angstrom, mu = 27.2 cm 1, F(000) = 252, T = 293 K, R = 0.0487 for all 1171 unique reflections. 4-Methylamidatetiazofurin [methyl 2-(beta-D-ribofuranosyl)thiazole-4-carboximidate, (2)], C10H14N2O5S, M(r) = 274.3, orthorhombic, P2(1)2(1)2(1) a = 8.596 (1), b = 11.060 (1), c = 26.064 (1) angstrom, V = 2478.1 (2) angstrom3, Z = 8, D(x) = 1.47 g cm-3 Cu Kalpha, angstrom = 1.54178 angstrom, mu = 24.5 cm-1, F(000) = 1152, T = 293 K, R = 0.0374 for all 2902 unique reflections. Compound (2) crystallizes with two crystallographic unique structures in the asymmetric unit [(2a) and (2b)]. All three structures show a close contact between the thiazole sulfur and the pentose oxygen O(1'). S...O(1') distances are 2.936 (3) angstrom in (1), 2.773 (2) angstrom in (2a) and 2.878 (2) angstrom in (2b), resulting from C-glycosidic torsion angles of 34.5 (4), 15.6 (3) and 27.2 (3) respectively. This interesting feature is conserved in the crystal structures of other thiazole nucleosides [Burling & Goldstein (1992). J. Am. Chem. Soc. 114, 2313-2320]. C1 UNIV ROCHESTER,MED CTR,DEPT BIOPHYS,ROCHESTER,NY 14642. USA,MED RES INST INFECT DIS,FREDERICK,MD 21702. FU NCI NIH HHS [CA-45145] NR 23 TC 8 Z9 8 U1 0 U2 0 PU MUNKSGAARD INT PUBL LTD PI COPENHAGEN PA 35 NORRE SOGADE, PO BOX 2148, DK-1016 COPENHAGEN, DENMARK SN 0108-7681 J9 ACTA CRYSTALLOGR B JI Acta Crystallogr. Sect. B-Struct. Commun. PD OCT 1 PY 1992 VL 48 BP 677 EP 683 DI 10.1107/S0108768192001101 PN 5 PG 7 WC Chemistry, Multidisciplinary; Crystallography SC Chemistry; Crystallography GA JU408 UT WOS:A1992JU40800017 PM 1463590 ER PT J AU IJSSELMUIDEN, CB GAYDOS, C FEIGHNER, B NOVAKOSKI, WL SERWADDA, D CARIS, LH VLAHOV, D COMSTOCK, GW AF IJSSELMUIDEN, CB GAYDOS, C FEIGHNER, B NOVAKOSKI, WL SERWADDA, D CARIS, LH VLAHOV, D COMSTOCK, GW TI CANCER OF THE PANCREAS AND DRINKING-WATER - A POPULATION-BASED CASE-CONTROL STUDY IN WASHINGTON COUNTY, MARYLAND SO AMERICAN JOURNAL OF EPIDEMIOLOGY LA English DT Article DE CASE-CONTROL STUDIES; CHLORINE; PANCREATIC NEOPLASMS; WATER SUPPLY ID RISK-FACTORS; CONSUMPTION; SMOKING; ALCOHOL; COFFEE; EPIDEMIOLOGY AB A case-control study was done to assess a potential association between drinking water and pancreatic cancer in Washington County, Maryland. Cases of pancreatic cancer occurring from 1975 through 1989 were identified from the cancer registry. Controls were selected from the private 1975 census of Washington County. There were 101 cases and 206 controls. Chlorinated municipal water was used as a source of drinking water by 79% of cases and 63% of controls, yielding a significant odds ratio of 2.2. Adjustment for age and smoking had almost no effect on the risk, although both age and smoking were independently associated with an increased risk of pancreatic cancer. Although these findings must be interpreted with caution because of limitations in exposure assessment, these results have implications for the prevention of pancreatic cancer because chlorination of water is so widely practiced. C1 MED UNIV S AFRICA,DEPT COMMUNITY HLTH,MEDUNSA,SOUTH AFRICA. JOHNS HOPKINS UNIV,DEPT MED,DIV INFECT DIS,BALTIMORE,MD 21218. WALTER REED ARMY INST RES,DIV PREVENT MED,WASHINGTON,DC 20307. MULAGO HOSP,MAKERERE MED SCH,DEPT MED,KAMPALA,UGANDA. UNIV CHILE,SCH HYG,SANTIAGO,CHILE. JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,DEPT EPIDEMIOL,BALTIMORE,MD 21218. RI Gaydos, Charlotte/E-9937-2010 FU NCI NIH HHS [CA 36390]; NHLBI NIH HHS [HL 21,670] NR 22 TC 31 Z9 33 U1 0 U2 1 PU JOHNS HOPKINS UNIV SCHOOL HYGIENE PUB HEALTH PI BALTIMORE PA 111 MARKET PLACE, STE 840, BALTIMORE, MD 21202-6709 SN 0002-9262 J9 AM J EPIDEMIOL JI Am. J. Epidemiol. PD OCT 1 PY 1992 VL 136 IS 7 BP 836 EP 842 PG 7 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA JY679 UT WOS:A1992JY67900007 PM 1442749 ER PT J AU KIKENDALL, JW GLASS, AR SOBIN, LH BOWEN, PE AF KIKENDALL, JW GLASS, AR SOBIN, LH BOWEN, PE TI SERUM GASTRIN IS NOT HIGHER IN SUBJECTS WITH COLONIC NEOPLASIA SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Article ID PERNICIOUS-ANEMIA; CANCER; GROWTH; RISK AB Two previous studies have shown higher circulating gastrin levels in subjects with colonic neoplasia than in colonoscopy-negative controls. In this much larger study, sera were collected from fasting subjects undergoing colonoscopy. Colonoscopy with biopsy classified participants as having colonic adenomas (N = 139), colon carcinomas (N = 29), or controls without colonic neoplasia (N = 150). Frozen, stored sera were later analyzed for gastrin by radioimmunoassay. Serum gastrin values were no higher in subjects with colonic adenomas or carcinoma than in colonoscopy-negative controls. We conclude that elevated serum gastrin levels play little, if any, role in the initiation of colonic neoplasia. C1 WALTER REED ARMY MED CTR,DEPT MED,ENDOCRINOL SERV,WASHINGTON,DC 20307. ARMED FORCES INST PATHOL,DIV GASTROINTESTINAL PATHOL,WASHINGTON,DC 20306. UNIV ILLINOIS,DEPT NUTR & MED DIETET,CHICAGO,IL 60680. RP KIKENDALL, JW (reprint author), WALTER REED ARMY MED CTR,DEPT MED,GASTROENTEROL SERV,WASHINGTON,DC 20307, USA. NR 9 TC 42 Z9 42 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD OCT PY 1992 VL 87 IS 10 BP 1394 EP 1397 PG 4 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA JT650 UT WOS:A1992JT65000007 PM 1415093 ER PT J AU KADAKIA, SC PARKER, A CANALES, L AF KADAKIA, SC PARKER, A CANALES, L TI METASTATIC TUMORS TO THE UPPER GASTROINTESTINAL-TRACT - ENDOSCOPIC EXPERIENCE SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Article ID RENAL-CELL CARCINOMA; SALVAGE CYTOLOGY; DIAGNOSIS; STOMACH; LESIONS; LUNG AB Metastatic tumors to the upper gastrointestinal tract were identified by esophagogastroduodenoscopy in 14 patients. Malignant melanoma, breast cancer, and lung cancer were the most common primary cancers in four, three, and three patients, respectively. Osteogenic sarcoma, renal cell carcinoma, Meckel cell carcinoma of the skin, and germ-cell tumor were the primary cancer in the remaining four. The esophagus was involved in three patients, the stomach in 13, duodenum in four, and papilla of Vater in one. Upper gastrointestinal bleeding and anemia were the most common presenting features. There was correlation between symptoms and endoscopic findings in all patients. Involvement of gastrointestinal tract at endoscopy was the initial and only evidence of metastases in all patients without evidence of metastases elsewhere, as evidenced by other diagnostic tests in any of these patients. Endoscopic biopsies and/or brush cytology provided histologic diagnosis in all 14 patients. The endoscopic and nonendoscopic literature regarding metastases to the upper gastrointestinal tract is reviewed. RP KADAKIA, SC (reprint author), BROOKE ARMY MED CTR,DEPT MED,GASTROENTEROL SERV,FT SAM HOUSTON,TX 78234, USA. NR 36 TC 73 Z9 73 U1 0 U2 2 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD OCT PY 1992 VL 87 IS 10 BP 1418 EP 1423 PG 6 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA JT650 UT WOS:A1992JT65000012 PM 1415098 ER PT J AU CANALES, LI PARKER, A KADAKIA, S AF CANALES, LI PARKER, A KADAKIA, S TI UPPER GASTROINTESTINAL-BLEEDING FROM MERKEL CELL-CARCINOMA SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Article ID TRABECULAR CARCINOMA; IMMUNOHISTOCHEMICAL ANALYSIS; NEUROENDOCRINE CARCINOMAS; ENDOCRINE CARCINOMA; SKIN; TUMOR; CHEMOTHERAPY; DIAGNOSIS AB Merkel cell carcinoma is a rare small cell carcinoma of the dermis with aggressive clinical features and frequent local recurrence. Intra-abdominal spread of the cancer has previously been noted primarily in the liver and retroperitoneal nodes. We report a patient with previously diagnosed Merkel cell carcinoma of the right buttock with metastases to the stomach and duodenum presenting with acute upper gastrointestinal bleeding. C1 BROOKE ARMY MED CTR,DEPT MED,GI ENDOSCOPY UNIT,FT SAM HOUSTON,TX 78234. BROOKE ARMY MED CTR,GASTROENTEROL SERV,FT SAM HOUSTON,TX 78234. NR 23 TC 21 Z9 21 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD OCT PY 1992 VL 87 IS 10 BP 1464 EP 1466 PG 3 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA JT650 UT WOS:A1992JT65000021 PM 1415105 ER PT J AU REID, TJ STAMM, CP DUNNING, DM REDMOND, J AF REID, TJ STAMM, CP DUNNING, DM REDMOND, J TI IRON MALABSORPTION IN A PATIENT WITH LARGE CELL LYMPHOMA INVOLVING TH DUODENUM SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Note ID DIFFUSE HISTIOCYTIC LYMPHOMA; GASTROINTESTINAL-TRACT AB Iron malabsorption compounded the anemia in a patient with diffuse large cell lymphoma involving the small intestine. Both upper gastrointestinal series with small bowel follow-through and computerized tomographic scan demonstrated lymphomatous involvement of the duodenum and proximal jejunum by a retroperitoneal mass. An oral iron-loading absorption test was consistent with malabsorption of iron. After two cycles of systemic chemotherapy, the retroperitoneal mass resolved and the iron loading test normalized. C1 WALTER REED ARMY MED CTR,DEPT MED,DIV HEMATOL ONCOL,DIV GASTROENTEROL,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,F EDWARD HEBERT SCH MED,DEPT MED,BETHESDA,MD 20814. RP REID, TJ (reprint author), WALTER REED ARMY MED CTR,DEPT HEMATOL,WASHINGTON,DC 20307, USA. NR 26 TC 3 Z9 4 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD OCT PY 1992 VL 87 IS 10 BP 1478 EP 1481 PG 4 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA JT650 UT WOS:A1992JT65000025 PM 1415109 ER PT J AU FEIGHNY, R BURROUS, J MCCOWN, J HOKE, C PUTNAK, R AF FEIGHNY, R BURROUS, J MCCOWN, J HOKE, C PUTNAK, R TI PURIFICATION OF NATIVE DENGUE-2 VIRAL-PROTEINS AND THE ABILITY OF PURIFIED PROTEINS TO PROTECT MICE SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID 341750-CARIB VIRUS-VACCINE; WEST NILE VIRUS; MONOCLONAL-ANTIBODIES; STRUCTURAL PROTEINS; IMMUNIZATION; ENCEPHALITIS; IMMUNOGENICITY; VOLUNTEERS; SEQUENCE; GENE AB Both the envelope structural protein and the non-structural NS1 protein have been purified from the flavivirus dengue-2 by high-pressure liquid chromatography. These purified proteins maintain their reactivity with monoclonal antibodies. When tested in mice, the envelope protein elicited neutralizing antibodies and partially protected the animals against a lethal viral challenge. The mice responded to the non-structural protein by producing antibodies; however, these antibodies were not neutralizing and the mice were not protected. RP FEIGHNY, R (reprint author), WALTER REED ARMY INST RES,DEPT VIRUS DIS,WASHINGTON,DC 20307, USA. NR 31 TC 21 Z9 23 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD OCT PY 1992 VL 47 IS 4 BP 405 EP 412 PG 8 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA JY570 UT WOS:A1992JY57000007 PM 1443338 ER PT J AU BROWN, AE WEBSTER, HK GORDON, DM PERMPANICH, B GROSS, M AF BROWN, AE WEBSTER, HK GORDON, DM PERMPANICH, B GROSS, M TI CHARACTERIZATION OF NATURALLY ACQUIRED ANTIBODIES TO THE NONREPETITIVE FLANKING REGIONS OF THE CIRCUMSPOROZOITE PROTEIN OF PLASMODIUM-FALCIPARUM SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID MALARIA; SPOROZOITES; RECOGNITION; VACCINE AB Antibody responses to the circumsporozoite (CS) protein of Plasmodium falciparum have previously been reported against the central repeating tetrapeptides of this protein. Segments of the protein flanking the repeat region also contain B-cell epitopes, but specific antibody responses have not been previously characterized. Longitudinal serum sets from 16 Thai adults who developed acute falciparum malaria were selected to represent a spectrum of antibody response to the repeat region (R32). These sera were assayed by enzyme-linked immunosorbent assay using as capture antigen a recombinant fusion protein, NS1(81)RLF, which contains both flanking regions, but lacks the NANP and NVDP repeats of the P. falciparum CS protein. Antibody responses to the repeatless flanking (RLF) regions were observed in all subjects, including five individuals who lacked detectable anti-R32 antibody responses. Anti-RLF antibody responses induced by natural infection appear to be short-lived and of low-to-moderate magnitude. Thus, if anti-RLF antibodies prove to be protective, derived vaccine candidates may require presentation of these epitopes with adjuvants or delivery systems that enhance immunogenicity. C1 WALTER REED ARMY INST RES,DEPT IMMUNOL,WASHINGTON,DC 20307. SMITHKLINE BEECHAM PHARMACEUT,DEPT MACROMOLEC SCI,KING OF PRUSSIA,PA 19406. RP BROWN, AE (reprint author), ARMED FORCES RES INST MED SCI,DEPT IMMUNOL,315-6 RAJVITHI RD,BANGKOK 10400,THAILAND. NR 12 TC 9 Z9 9 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD OCT PY 1992 VL 47 IS 4 BP 440 EP 445 PG 6 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA JY570 UT WOS:A1992JY57000011 PM 1443340 ER PT J AU BEACH, RF CORDONROSALES, C MOLINA, E WIRTZ, RA AF BEACH, RF CORDONROSALES, C MOLINA, E WIRTZ, RA TI FIELD-EVALUATION OF AN ENZYME-LINKED-IMMUNOSORBENT-ASSAY FOR ESTIMATING THE SPOROZOITE RATE IN ANOPHELES-ALBIMANUS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID PLASMODIUM-VIVAX SPOROZOITES; MALARIA PARASITE; CIRCUMSPOROZOITE PROTEINS; MONOCLONAL-ANTIBODIES; INFECTED MOSQUITOS; FALCIPARUM; IDENTIFICATION; ELISA AB We have verified for specimens of Anopheles albimanus that an enzyme-linked immunosorbent assay (ELISA) used to assess Plasmodium vivax and P. falciparum sporozoite antigen rates gives results comparable to the salivary gland dissection method for estimating sporozoite rates. For 14,150 adults of An. albimanus, captured at five locations in Guatemala, we report sporozoite antigen rates of 0.03-0.57%, which correlate with the malaria prevalences at the study sites. We also present data that suggest that specimens of An. albimanus for the ELISA can be obtained more efficiently by cattle corral collections than by the human bait capture method. C1 MED ENTOMOL RES & TRAINING UNIT,GUATEMALA CITY,GUATEMALA. CTR DIS CONTROL,NATL CTR INFECT DIS,DIV PARASIT DIS,ATLANTA,GA 30333. UNIV VALLE,GUATEMALA CITY,GUATEMALA. WALTER REED ARMY INST RES,DEPT ENTOMOL,DIV COMMUNICABLE DIS & IMMUNOL,WASHINGTON,DC 20307. NR 24 TC 4 Z9 5 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD OCT PY 1992 VL 47 IS 4 BP 478 EP 483 PG 6 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA JY570 UT WOS:A1992JY57000017 PM 1443346 ER PT J AU WEBSTER, HK GINGRICH, JB WONGSRICHANALAI, C TULYAYON, S SUVARNAMANI, A SOOKTO, P PERMPANICH, B AF WEBSTER, HK GINGRICH, JB WONGSRICHANALAI, C TULYAYON, S SUVARNAMANI, A SOOKTO, P PERMPANICH, B TI CIRCUMSPOROZOITE ANTIBODY AS A SEROLOGIC MARKER OF PLASMODIUM-FALCIPARUM TRANSMISSION SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID HYPERENDEMIC MALARIA; REPETITIVE EPITOPE; PROTEIN; SPOROZOITE; IMMUNITY; VACCINE; AREA; MICE; PROTECTION; POPULATION AB In a longitudinal study of a malaria-endemic village in southeastern Thailand, circumsporozoite (CS) antibody to sporozoites of Plasmodium falciparum was measured by an enzyme-linked immunosorbent assay to determine its usefulness as a seroepidemiologic marker of malaria transmission. The CS anti-(NANP)n antibody level and prevalence during a 25-month period paralleled the pattern of seasonal transmission consistent with conventional parasitologic and entomologic measurements. The prevalence and level of antibody decreased during the non-transmission wet season, and increased over a 1-2-month transition period between the end of monsoon rains and the onset of dry conditions, an interval of maximum vector activity. Antibody increased with age in the population. The prevalence of antibody to the asexual blood stage as measured by conventional indirect fluorescent antibody assay did not coincide with changes in transmission and was sustained throughout the study period. Thus, CS antibody appeared to reflect the relative population exposure to mosquito inoculation of P. falciparum sporozoites and provided a useful measure of malaria transmission dynamics. C1 USA,MED COMPONENT,ARMED FORCES RES INST MED SCI,DEPT IMMUNOL,BANGKOK,THAILAND. USA,MED COMPONENT,ARMED FORCES RES INST,DEPT ENTOMOL,BANGKOK,THAILAND. NR 39 TC 37 Z9 38 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD OCT PY 1992 VL 47 IS 4 BP 489 EP 497 PG 9 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA JY570 UT WOS:A1992JY57000019 PM 1443348 ER PT J AU SNYDER, AP HARDEN, CS BRITTAIN, AH KIM, MG ARNOLD, NS MEUZELAAR, HLC AF SNYDER, AP HARDEN, CS BRITTAIN, AH KIM, MG ARNOLD, NS MEUZELAAR, HLC TI PORTABLE, HAND-HELD GAS-CHROMATOGRAPHY ION MOBILITY SPECTROMETER SO AMERICAN LABORATORY LA English DT Article AB A hand-held GC/ion mobility spectrometer system is described which provides analysis of mixtures of common organic compounds outside the laboratory. C1 GRASEBY ION LTD,WATFORD,HERTS,ENGLAND. UNIV UTAH,CHEM ENGN,SALT LAKE CITY,UT 84112. RP SNYDER, AP (reprint author), USA,CTR CHEM RES DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010, USA. NR 13 TC 13 Z9 13 U1 0 U2 1 PU INT SCIENTIFIC COMMUN INC PI SHELTON PA PO BOX 870, 30 CONTROLS DRIVE, SHELTON, CT 06484-0870 SN 0044-7749 J9 AM LAB JI Am. Lab. PD OCT PY 1992 VL 24 IS 15 BP B32 EP & PG 0 WC Chemistry, Analytical; Instruments & Instrumentation SC Chemistry; Instruments & Instrumentation GA JT820 UT WOS:A1992JT82000005 ER PT J AU JACKSON, MR OLSON, DW BECKETT, WC OLSEN, SB ROBERTSON, FM AF JACKSON, MR OLSON, DW BECKETT, WC OLSEN, SB ROBERTSON, FM TI ABDOMINAL VASCULAR TRAUMA - A REVIEW OF 106 INJURIES SO AMERICAN SURGEON LA English DT Article ID INFERIOR VENA-CAVA; THORACOTOMY; MANAGEMENT; EMERGENCY AB A retrospective analysis of acute abdominal vascular injuries was performed to review outcome variables and treatment principles. The authors review their most recent 5-year experience with 106 major abdominal vascular injuries in 64 patients treated at a combined Army and Air Force urban medical center. The majority of the patients were young men who sustained penetrating injuries. There were 41 (64%) gunshot wounds, 17 (27%) stab wounds, and 6 (9%) sustained blunt trauma. Forty-five patients (71%) came to the hospital in shock. The inferior vena cava in 26 patients (41%) and the aorta in 11 patients (17%) were injured most frequently. Suture repair was possible in 53 (50%) injuries. Ligation was performed in 41 (39%). Overall mortality for the series was 39 per cent. Hemorrhagic shock was the cause of death in 23 patients (92%) with only two late deaths. Transfusion requirement, presence of shock, and number of vessels injured all affected outcome. Immediate stabilization in the emergency department includes appropriate crystalloid and blood product resuscitation with minimal delay for diagnostic studies. Prompt abdominal exploration to control hemorrhage and particular attention to factors associated with coagulopathy remain the key elements in saving the lives of these severely injured patients. C1 USA,DEPT SURG,VASC SURG SERV,JOINT MIL MED COMMAND,SAN ANTONIO,TX. NR 24 TC 35 Z9 35 U1 0 U2 1 PU SOUTHEASTERN SURGICAL CONGRESS PI ATLANTA PA 1776 PEACHTREE RD, NW., SUITE 410N, ATLANTA, GA 30309-2352 SN 0003-1348 J9 AM SURGEON JI Am. Surg. PD OCT PY 1992 VL 58 IS 10 BP 622 EP 626 PG 5 WC Surgery SC Surgery GA JT880 UT WOS:A1992JT88000006 PM 1416435 ER PT J AU UNGER, SW SATAVA, RM SCOTT, JS AF UNGER, SW SATAVA, RM SCOTT, JS TI RESIDENT EDUCATION IN SURGICAL ENDOSCOPY SO AMERICAN SURGEON LA English DT Article ID PROGRAM AB Under the auspices of the Resident Education Committee of the Society of American Gastrointestinal Endoscopic Surgeons, 158 of 298 (53%) of surgical training program directors responded to a survey on the current status of endoscopy in residency programs. Although 100 per cent claim that gastrointestinal endoscopy is provided by their program, only 76 per cent have formal endoscopy training, usually centered around the PGY 3 level, with only 23 per cent having didactic lectures in endoscopy. Directors claim to have trained nearly all of their residents by the completion of residency, averaging 44 esophagogastroscopies, 37 colonoscopies, and 46 flexible sigmoidoscopies per resident. However, they feel only 71 per cent of trainees are able to perform esophagogastroscopies and 67 per cent to perform colonoscopies in clinical practice. Ninety-seven per cent of directors feel endoscopy is important to surgical residency training, and 87 per cent have full-time faculty doing endoscopy. Only 44 per cent have a director of endoscopy; endoscopy is supervised by surgeons exclusively in only 48 per cent. Only 35 per cent have ongoing endoscopy research. When surgeons are not performing endoscopy, 66 per cent feel that the gastrointestinal (GI) service provides adequate service or training. Gastroenterology has a monopoly in endoscopy at 28 per cent of institutions, and 67 per cent of program directors feel there would be resistance to the formation of a separate surgical endoscopy service. Surgeons work in their own surgical endoscopy suite in only 15 per cent of institutions; in a GI suite in 13 per cent; and in a combined suite in the remainder. Direct viewing fiberoptic equipment is used in 38 per cent of programs; video equipment is used in 17 per cent; and both systems in the remainder, with 44 per cent planning to phase in video completely. Quality assurance is performed for endoscopy at 86 per cent of institutions. These data indicate that while surgical endoscopy has made significant strides in recent years, it has not yet been fully incorporated into surgical residency training. Of the areas for improvement, designation of a specific staff surgeon as director of endoscopy, incorporation of didactic lectures and research, and monitoring of quality assurance are important to full development of a surgical endoscopy training program. C1 MT SINAI MED CTR,DEPT SURG,DIV SURG ENDOSCOPY,MIAMI BEACH,FL 33140. USA,SURG ENDOSCOPY TRAINING PROGRAM,MONTEREY,CA. NR 8 TC 4 Z9 4 U1 0 U2 0 PU SOUTHEASTERN SURGICAL CONGRESS PI ATLANTA PA 1776 PEACHTREE RD, NW., SUITE 410N, ATLANTA, GA 30309-2352 SN 0003-1348 J9 AM SURGEON JI Am. Surg. PD OCT PY 1992 VL 58 IS 10 BP 643 EP 646 PG 4 WC Surgery SC Surgery GA JT880 UT WOS:A1992JT88000012 PM 1416440 ER PT J AU DUCEY, JP KNAPE, KG AF DUCEY, JP KNAPE, KG TI MATERNAL ESMOLOL ADMINISTRATION RESULTING IN FETAL DISTRESS AND CESAREAN-SECTION IN A TERM PREGNANCY SO ANESTHESIOLOGY LA English DT Article DE ANESTHESIA; OBSTETRIC; COMPLICATIONS; FETAL BRADYCARDIA; SUPRAVENTRICULAR TACHYCARDIA; SYMPATHETIC NERVOUS SYSTEM, BETA-ADRENERGIC ANTAGONISTS; ESMOLOL ID HEART-RATE; TACHYCARDIA; HYPERTENSION; INTUBATION; HYPOXEMIA; BLOCKADE; SHEEP C1 BROOKE ARMY MED CTR,ANESTHESIOL SERV,FT SAM HOUSTON,TX 78234. UNIV TEXAS,HLTH SCI CTR,DEPT ANESTHESIOL,SAN ANTONIO,TX 78284. NR 21 TC 18 Z9 18 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0003-3022 J9 ANESTHESIOLOGY JI Anesthesiology PD OCT PY 1992 VL 77 IS 4 BP 829 EP 832 DI 10.1097/00000542-199210000-00034 PG 4 WC Anesthesiology SC Anesthesiology GA JR748 UT WOS:A1992JR74800034 PM 1358006 ER PT J AU WILLIAMS, HL JOHNSON, DJ OKOYE, VCN MARTIN, SK AF WILLIAMS, HL JOHNSON, DJ OKOYE, VCN MARTIN, SK TI TREATMENT OF CHLOROQUINE-RESISTANT MALARIA IN MONKEYS WITH A DRUG-COMBINATION THAT REVERSES RESISTANCE INVITRO SO ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY LA English DT Article ID PLASMODIUM-FALCIPARUM; MULTIDRUG-RESISTANCE; CALCIUM-ANTAGONISTS; DESIPRAMINE; EXPRESSION RP WILLIAMS, HL (reprint author), WALTER REED ARMY INST RES,DIV MED,DEPT HEMATOL,WASHINGTON,DC 20307, USA. NR 14 TC 3 Z9 3 U1 0 U2 0 PU CARFAX PUBL CO PI ABINGDON PA PO BOX 25, ABINGDON, OXFORDSHIRE, ENGLAND OX14 3UE SN 0003-4983 J9 ANN TROP MED PARASIT JI Ann. Trop. Med. Parasitol. PD OCT PY 1992 VL 86 IS 5 BP 467 EP 473 PG 7 WC Public, Environmental & Occupational Health; Parasitology; Tropical Medicine SC Public, Environmental & Occupational Health; Parasitology; Tropical Medicine GA KE887 UT WOS:A1992KE88700003 PM 1288427 ER PT J AU SMITH, KJ KONZELMAN, JL LOMBARDO, FA SKELTON, HG HOLLAND, TT YEAGER, J WAGNER, KF OSTER, CN CHUNG, R AF SMITH, KJ KONZELMAN, JL LOMBARDO, FA SKELTON, HG HOLLAND, TT YEAGER, J WAGNER, KF OSTER, CN CHUNG, R TI IONTOPHORESIS OF VINBLASTINE INTO NORMAL SKIN AND FOR TREATMENT OF KAPOSI-SARCOMA IN HUMAN IMMUNODEFICIENCY VIRUS-POSITIVE PATIENTS SO ARCHIVES OF DERMATOLOGY LA English DT Article ID HIV-INFECTION; PHARMACOKINETICS; MICROTUBULES; CELLS AB Background.-Patients who test positive for human immunodeficiency virus type 1 (HIV-1) and who have disfiguring and/or painful cutaneous lesions of Kaposi's sarcoma (KS) may not be candidates for systemic chemotherapy and/or immunotherapy. Intralesional vinblastine sulfate, as a single-agent chemotherapeutic drug, has been used with some success to treat KS in patients who are HIV-1 positive. However, some patients may not tolerate the pain asociated with injection of vinblastine. Transcutaneous iontophoresis of vinblastine was evaluated for therapy of KS in HIV-1-infected patients. Prior to therapy of patients, we iontophoresed vinblastine into the normal skin of volunteers who were not infected with HIV-1 to document the clinical and histologic features that occurred. Observations.-Iontophoresis produced a localized erythematous papular eruption in non-HIV-infected volunteers but not in HIV-1-infected patients. Histologic changes in the biopsy specimens taken from non-HIV-infected volunteers consisted primarily of scattered necrotic keratinocytes and a mild to moderate superficial lymphohistiocytic infiltrate. Thirty-one lesions of KS were treated with partial to complete clearing and symptomatic improvement. Conclusion.-Clinical and histologic features of iontophoresed normal skin suggest an immunologic mechanism of action. Ionotophoresis of vinblastine for KS is well tolerated and results in symptomatic improvement as well as varying degrees of clearing of the lesions. C1 ARMED FORCES INST PATHOL, DEPT DERMATOPATHOL, WASHINGTON, DC 20306 USA. WALTER REED ARMY MED CTR, DEPT MED, INFECT DIS SERV, WASHINGTON, DC 20307 USA. HENRY M JACKSON FDN, BETHESDA, MD USA. WALTER REED ARMY MED CTR, HEMATOL ONCOL SERV, CANC TREATMENT SECT, WASHINGTON, DC 20307 USA. NATL NAVAL MED CTR, DEPT DERMATOL, BETHESDA, MD 20814 USA. FU NIAMS NIH HHS [AY01AR90008, NY01AR00014] NR 22 TC 21 Z9 21 U1 0 U2 2 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0003-987X J9 ARCH DERMATOL JI Arch. Dermatol. PD OCT PY 1992 VL 128 IS 10 BP 1365 EP 1370 DI 10.1001/archderm.128.10.1365 PG 6 WC Dermatology SC Dermatology GA JT343 UT WOS:A1992JT34300009 PM 1417025 ER PT J AU WILKESON, RW NGUYEN, TH GUILL, MA AF WILKESON, RW NGUYEN, TH GUILL, MA TI ERYTHEMATOUS, VESICULAR LESIONS IN A NEWBORN - DIAGNOSIS - INCONTINENTIA PIGMENTI SO ARCHIVES OF DERMATOLOGY LA English DT Note RP WILKESON, RW (reprint author), DWIGHT D EISENHOWER ARMY MED CTR,FT GORDON,GA 30905, USA. NR 5 TC 1 Z9 1 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0003-987X J9 ARCH DERMATOL JI Arch. Dermatol. PD OCT PY 1992 VL 128 IS 10 BP 1395 EP & PG 0 WC Dermatology SC Dermatology GA JT343 UT WOS:A1992JT34300018 PM 1417031 ER PT J AU SMITH, WB GRABSKI, WJ MCCOLLOUGH DAVIS, TL AF SMITH, WB GRABSKI, WJ MCCOLLOUGH DAVIS, TL TI IMMUNOFLUORESCENCE FINDINGS IN LICHEN-PLANOPILARIS - A CONTRASTING EXPERIENCE SO ARCHIVES OF DERMATOLOGY LA English DT Letter C1 WILFORD HALL USAF MED CTR,LACKLAND AFB,TX 78236. RP SMITH, WB (reprint author), BROOKE ARMY MED CTR,DERMATOL SERV,FT SAM HOUSTON,TX 78234, USA. NR 3 TC 7 Z9 7 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0003-987X J9 ARCH DERMATOL JI Arch. Dermatol. PD OCT PY 1992 VL 128 IS 10 BP 1405 EP 1406 PG 2 WC Dermatology SC Dermatology GA JT343 UT WOS:A1992JT34300023 PM 1417036 ER PT J AU CALDWELL, JA STEPHENS, RL CARTER, DJ JONES, HD AF CALDWELL, JA STEPHENS, RL CARTER, DJ JONES, HD TI EFFECTS OF 2 MG AND 4 MG ATROPINE SULFATE ON THE PERFORMANCE OF UNITED-STATES-ARMY HELICOPTER PILOTS SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article AB Atropine autoinjectors are issued to aviators for use in the event of organophosphate poisoning on the battlefield. This investigation assessed the effects of unchallenged 2 mg and 4 mg doses on flight performance, vision, tracking, cognitive performance, and electroencephalograms of 12 Army aviators. Effects were seen most often with the 4 mg dose in terms of aircraft control problems, vision disturbances, impaired tracking, reduced cortical activation, and decreased cognitive skill. These problems indicate helicopter tactical flight is dangerous after an unchallenged 4 mg dose. Other types of flight should also be avoided for at least 12 h after atropine. RP CALDWELL, JA (reprint author), USA,AEROMED RES LAB,DIV BIOMED APPLICAT RES,CREW STRESS & WORKLOAD BRANCH,SGRD-UAB-CS,BOX 577,FT RUCKER,AL 36362, USA. NR 15 TC 8 Z9 8 U1 0 U2 0 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD OCT PY 1992 VL 63 IS 10 BP 857 EP 864 PG 8 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA JQ395 UT WOS:A1992JQ39500001 PM 1417646 ER PT J AU CALDWELL, JL CORNUM, RLS AF CALDWELL, JL CORNUM, RLS TI DOCUMENTATION OF ACTIVITY AND REST OF A UNITED-STATES-NATIONAL-GUARD ATTACK HELICOPTER BATTALION SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Note ID SLEEP; PERFORMANCE; CYCLE AB A. U.S. National Guard attack helicopter battalion was monitored in order to document the activity and rest obtained during the annual training exercises. A total of 39 soldiers wore wrist activity monitors during the 2-week training period. The data from these monitors discriminate activity from rest. Results indicated the following: 1) at some point during the exercises, everyone became sleep deprived; 2) the participants who received the most rest of the group were the enlisted headquarters personnel and the pilots; 3) the soldiers who received the least amount of sleep were the commander of the battalion and the maintenance personnel. Some recommendations are offered for future planning of National Guard training exercises. RP CALDWELL, JL (reprint author), USA,AEROMED RES LAB,DIV BIOMED APPLICAT RES,CREW LIFE SUPPORT BRANCH,POB 577,FT RUCKER,AL 36362, USA. NR 14 TC 5 Z9 5 U1 0 U2 0 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD OCT PY 1992 VL 63 IS 10 BP 925 EP 929 PG 5 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA JQ395 UT WOS:A1992JQ39500013 PM 1417658 ER PT J AU HEYES, MP SAITO, K CROWLEY, JS DAVIS, LE DEMITRACK, MA DER, M DILLING, LA ELIA, J KRUESI, MJP LACKNER, A LARSEN, SA LEE, K LEONARD, HL MARKEY, SP MARTIN, A MILSTEIN, S MOURADIAN, MM PRANZATELLI, MR QUEARRY, BJ SALAZAR, A SMITH, M STRAUSS, SE SUNDERLAND, T SWEDO, SW TOURTELLOTTE, WW AF HEYES, MP SAITO, K CROWLEY, JS DAVIS, LE DEMITRACK, MA DER, M DILLING, LA ELIA, J KRUESI, MJP LACKNER, A LARSEN, SA LEE, K LEONARD, HL MARKEY, SP MARTIN, A MILSTEIN, S MOURADIAN, MM PRANZATELLI, MR QUEARRY, BJ SALAZAR, A SMITH, M STRAUSS, SE SUNDERLAND, T SWEDO, SW TOURTELLOTTE, WW TI QUINOLINIC ACID AND KYNURENINE PATHWAY METABOLISM IN INFLAMMATORY AND NONINFLAMMATORY NEUROLOGICAL DISEASE SO BRAIN LA English DT Article ID CENTRAL-NERVOUS-SYSTEM; SIMIAN IMMUNODEFICIENCY VIRUS; INFECTED RHESUS MACAQUES; CHRONIC FATIGUE SYNDROME; CEREBROSPINAL-FLUID; HUNTINGTONS-DISEASE; INDOLEAMINE 2,3-DIOXYGENASE; RAT-BRAIN; TRYPTOPHAN-METABOLITES; ALZHEIMERS-DISEASE AB Neurological dysfunction, seizures and brain atrophy occur in a broad spectrum of acute and chronic neurological diseases. In certain instances, over-stimulation of N-methyl-D-aspartate receptors has been implicated. Quinolinic acid (QUIN) is an endogenous N-methyl-D-aspartate receptor agonist synthesized froM L-tryptophan via the kynurenine pathway and thereby has the potential of mediating N-methyl-D-aspartate neuronal damage and dysfunction. Conversely, the related metabolite, kynurenic acid, is an antagonist of N-methyl-D-aspartate receptors and could modulate the neurotoxic effects of QUIN as well as disrupt excitatory amino acid neurotransmission. In the present study, markedly increased concentrations of QUIN were found in both lumbar cerebrospinal fluid (CSF) and post-mortem brain tissue of patients with inflammatory diseases (bacterial, viral, fungal and parasitic infections, meningitis, autoimmune diseases and septicaemia) independent of breakdown of the blood-brain barrier. The concentrations of kynurenic acid were also increased, but generally to a lesser degree than the increases in QUIN. In contrast, no increases in CSF QUIN were found in chronic neurodegenerative disorders, depression or myoclonic seizure disorders, while CSF kynurenic acid concentrations were significantly lower in Huntington's disease and Alzheimer's disease. In inflammatory disease patients, proportional increases in CSF L-kynurenine and reduced L-tryptophan accompanied the increases in CSF QUIN and kynurenic acid. These responses are consistent with induction of indoleamine-2,3-dioxygenase, the first enzyme of the kynurenine pathway which converts L-tryptophan to kynurenic acid and QUIN. Indeed, increases in both indoleamine-2,3-dioxygenase activity and QUIN concentrations were observed in the cerebral cortex of macaques infected with retrovirus. particularly those with local inflammatory lesions. Correlations between CSF QUIN, kynurenic acid and L-kynurenine with markers of immune stimulation (neopterin, white blood cell counts and IgG levels) indicate a relationship between accelerated kynurenine pathway metabolism and the degree of intracerebral immune stimulation. We conclude that inflammatory diseases are associated with accumulation of QUIN, kynurenic acid and L-kynurenine within the central nervous system, but that the available data do not support a role for QUIN in the aetiology of Huntington's disease or Alzheimer's disease. In conjunction with our previous reports that CSF QUIN concentrations are correlated to objective measures of neuropsychological deficits in HIV-1-infected patients, we hypothesize that QUIN and kynurenic acid are mediators of neuronal dysfunction and nerve cell death in inflammatory diseases. Therefore, strategies to attenuate the neurological effects of kynurenine pathway metabolites or attenuate the rate of their synthesis offer new approaches to therapy. C1 NIMH,CLIN NEUROENDOCRINOL BRANCH,BETHESDA,MD 20892. NIMH,CHILD PSYCHIAT BRANCH,BETHESDA,MD 20892. NIMH,CLIN SCI LAB,CLIN PHARMACOL SECT,BETHESDA,MD 20892. NIMH,NEUROCHEM LAB,BETHESDA,MD 20892. NIH,DEPT NUCL MED,BETHESDA,MD 20892. NINCDS,EXPTL THERAPEUT BRANCH,BETHESDA,MD 20892. NIAID,CLIN INVEST LAB,BETHESDA,MD 20892. VET ADM MED CTR,NEUROL SERV,ALBUQUERQUE,NM 87108. CALIF REG PRIMATE CTR,DAVIS,CA. CTR DIS CONTROL,CTR INFECT DIS,ATLANTA,GA 30333. GEORGE WASHINGTON UNIV,DEPT NEUROL,WASHINGTON,DC 20052. WALTER REED ARMY MED CTR,DEPT NEUROL,WASHINGTON,DC 20307. NEUROL & RES SERV,LOS ANGELES,CA. NATL NEUROL BANK,LOS ANGELES,CA. UNIV MANITOBA,DEPT PEDIAT & CHILD HLTH,WINNIPEG R3T 2N2,MANITOBA,CANADA. RP HEYES, MP (reprint author), NIMH,CLIN SCI LAB,ANALYT BIOCHEM SECT,BLDG 10,ROOM 3D40,9000 ROCKVILLE PIKE,BETHESDA,MD 20892, USA. RI martin, alex/B-6176-2009; Demitrack, Mark/I-7697-2013; OI Mouradian, M. Maral/0000-0002-9937-412X FU NCRR NIH HHS [RR00039] NR 73 TC 446 Z9 453 U1 2 U2 30 PU OXFORD UNIV PRESS UNITED KINGDOM PI OXFORD PA WALTON ST JOURNALS DEPT, OXFORD, ENGLAND OX2 6DP SN 0006-8950 J9 BRAIN JI Brain PD OCT PY 1992 VL 115 BP 1249 EP 1273 DI 10.1093/brain/115.5.1249 PN 5 PG 25 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA JY715 UT WOS:A1992JY71500001 PM 1422788 ER PT J AU BEVAN, KA NEWMAN, AH BOWERY, NG TORTELLA, FC AF BEVAN, KA NEWMAN, AH BOWERY, NG TORTELLA, FC TI MECHANISM OF THE ANTICONVULSANT ACTION OF DEXTROMETHORPHAN ANALOGS IN RAT-BRAIN SO BRITISH JOURNAL OF PHARMACOLOGY LA English DT Meeting Abstract C1 UNIV LONDON,DEPT PHARMACOL,LONDON WC1N 1AX,ENGLAND. NIDA,ADDICT RES CTR,BALTIMORE,MD 21224. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 4 TC 2 Z9 2 U1 0 U2 2 PU STOCKTON PRESS PI BASINGSTOKE PA HOUNDMILLS, BASINGSTOKE, HAMPSHIRE, ENGLAND RG21 6XS SN 0007-1188 J9 BRIT J PHARMACOL JI Br. J. Pharmacol. PD OCT PY 1992 VL 107 SU S BP P62 EP P62 PG 1 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA JR252 UT WOS:A1992JR25200062 ER PT J AU TORRINGTON, KG POROPATICH, RK AF TORRINGTON, KG POROPATICH, RK TI UTILITY OF REPEATED FIBEROPTIC BRONCHOSCOPY FOR SUSPECTED MALIGNANCY SO CHEST LA English DT Article AB We retrospectively evaluated records of 1598 fiberoptic bronchoscopies (FBs) performed on 1,391 patients (PTs) between jan 1, 1986 and Dec 31, 1990. We found a progressive increase from 11 percent to 20 percent in the use of repeated fiberoptic bronchoscopy (RFB). Of the 254 RFBs, 151 were done in PTs with known or suspected intrathoracic malignant neoplasms. The 78 (of 151) RFBs performed in PTs with previously diagnosed malignant neoplasms were used to guide additional therapy. The other major indication for RFB (67 of 151) was to evaluate new suspicious lesions that had not been diagnosed on the initial FB. RFB specimens were positive in 36, false-negative in 24, and true-negative in 7 PTs. For some PTs, RFB could probably have been avoided if at initial FB physicians had (1) used fluoroscopy to direct transbronchial lung biopsies in PTs expected to have normal airways, (2) performed transbronchial needle aspiration in all PTs with extraluminal disease or mediastinal adenopathy, and (3) obtained bronchial biopsy specimens from all PTs with endobronchial lesions. In PTs whose initial FB specimens were nondiagnostic despite visualization of endobronchial or extraluminal abnormalities, RFB was associated with a significant diagnostic yield and obviated the need for more morbid, surgical staging procedures. RP TORRINGTON, KG (reprint author), WALTER REED ARMY MED CTR,DIV PULM,WASHINGTON,DC 20307, USA. NR 9 TC 2 Z9 2 U1 0 U2 0 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 SN 0012-3692 J9 CHEST JI Chest PD OCT PY 1992 VL 102 IS 4 BP 1080 EP 1084 DI 10.1378/chest.102.4.1080 PG 5 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA JR495 UT WOS:A1992JR49500021 PM 1395747 ER PT J AU HAYS, JV GILMAN, JK RUBAL, BJ AF HAYS, JV GILMAN, JK RUBAL, BJ TI EFFECT OF MAGNESIUM ON VENTRICULAR RATE CONTROL IN ATRIAL-FIBRILLATION SO CIRCULATION LA English DT Meeting Abstract C1 BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER HEART ASSOC PI DALLAS PA 7272 GREENVILLE AVENUE, DALLAS, TX 75231-4596 SN 0009-7322 J9 CIRCULATION JI Circulation PD OCT PY 1992 VL 86 IS 4 SU S BP 664 EP 664 PG 1 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA JT660 UT WOS:A1992JT66002662 ER PT J AU LAUER, CG BURGE, R TANG, DB BASS, BG GOMEZ, ER ALVING, BM AF LAUER, CG BURGE, R TANG, DB BASS, BG GOMEZ, ER ALVING, BM TI EFFECT OF ULTRASOUND ON TISSUE-TYPE PLASMINOGEN-ACTIVATOR INDUCED THROMBOLYSIS SO CIRCULATION LA English DT Article DE FIBRINOLYSIS; ULTRASOUND; THROMBOSIS; PLASMINOGEN ACTIVATORS ID JUGULAR VEIN-THROMBOSIS; ARTERIAL RECANALIZATION; ANGIOPLASTY; THERAPY; INVITRO; INVIVO; RABBIT; MODEL AB Background. The efficacy of fibrinolytic therapy is limited by the small surface area of the clot that is available for the binding of the thrombolytic agent, such as tissue-type plasminogen activator (t-PA). We hypothesized that exposure of the clot to ultrasound during thrombolytic treatment could enhance lysis through perturbation of the thrombus, which would expose additional fibrin binding sites for t-PA. Methods and Results. Whole human blood clots containing radiolabeled fibrinogen were incubated in vitro for 200 minutes with Tris-albumin buffer containing t-PA at concentrations ranging from 3 to 3,000 IU/ml. In paired experiments, one of the clots also was exposed to intermittent ultrasound (1 MHz, 1.75 W/cm2) throughout the experiment. The ultrasound was delivered as a 2-second exposure followed by a 2-second rest interval. The overall difference in mean clot lysis between thrombi receiving ultrasound and those receiving no ultrasound was significant (p<0.001) at all concentrations of t-PA. For clots incubated with t-PA at a concentration of 300 IU/ml, ultrasound increased the percent lysis at 200 minutes from 42+/-5% (mean+/-SEM) to 64+/-10%. In six paired experiments in a rabbit jugular vein thrombosis model, rabbits received 1 mg t-PA alone or t-PA and intermittent ultrasound (1 MHz, 1.75 W/cm2) for 200 minutes. For rabbits receiving ultrasound and t-PA, lysis was 55+/-11% at 100 minutes compared with 30+/-12% for rabbits receiving only t-PA. Lysis was 6+/-10% for rabbits (n=4) receiving ultrasound alone. No evidence for tissue damage was noted in rabbits exposed to intermittent ultrasound. Conclusions. Exposure of whole blood clots in vitro to intermittent ultrasound combined with t-PA caused a significant enhancement of thrombolysis compared with t-PA alone. Intermittent ultrasound also showed a trend toward enhancement of t-PA-induced clot lysis in an animal thrombosis model. These data suggest that noninvasive intermittent ultrasound may be a useful adjunct to thrombolytic therapy. C1 WALTER REED ARMY MED CTR,DEPT HEMATOL,BLDG 40,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DIV BIOMETR,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DIV INSTRUMENTAT,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT VASC SURG,WASHINGTON,DC 20307. NR 29 TC 161 Z9 168 U1 1 U2 3 PU AMER HEART ASSOC PI DALLAS PA 7272 GREENVILLE AVENUE, DALLAS, TX 75231-4596 SN 0009-7322 J9 CIRCULATION JI Circulation PD OCT PY 1992 VL 86 IS 4 BP 1257 EP 1264 PG 8 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA JR938 UT WOS:A1992JR93800021 PM 1394932 ER PT J AU EMBRY, RL DELAPLAIN, CB AF EMBRY, RL DELAPLAIN, CB TI SCINTIGRAPHIC PITFALL IN A PATIENT WITH STEATOPYGIA SO CLINICAL NUCLEAR MEDICINE LA English DT Article AB A 37-year-old female with coccyx pain was imaged with planar and SPECT bone scintigraphy. Decreased uptake was noted at L4 and L5. MRI was also performed as part of further patient evaluation. A "shelf" of paragluteal adipose tissue (steatopygia) was incidentally noted as the cause of the apparent decreased uptake on bone imaging. RP EMBRY, RL (reprint author), TRIPLER ARMY MED CTR,DEPT RADIOL,NUCL MED SERV,HONOLULU,HI 96859, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0363-9762 J9 CLIN NUCL MED JI Clin. Nucl. Med. PD OCT PY 1992 VL 17 IS 10 BP 824 EP 826 DI 10.1097/00003072-199210000-00018 PG 3 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA JT386 UT WOS:A1992JT38600018 PM 1424366 ER PT J AU OSWALD, SG DAVIDS, R AF OSWALD, SG DAVIDS, R TI ACCUMULATION OF IN-111 LABELED WHITE BLOOD-CELLS IN A WOUND DRESSING - A POTENTIAL CAUSE OF FALSE-POSITIVE RESULTS SO CLINICAL NUCLEAR MEDICINE LA English DT Article AB Although In-111 WBC scintigraphy is of proven usefulness in the evaluation of suspected osteomyelitis, there are pitfalls that may trap the unwary interpreter, potentially leading to false-positive interpretations. The authors describe a patient with In-111 WBC accumulation in a dressing that covered a draining skin ulcer, giving rise to focal activity overlying the site of the suspected osteomyelitis. In patients undergoing In-WBC scintigraphy who have open wounds, all dressings should be removed or changed immediately before imaging. C1 DWIGHT D EISENHOWER ARMY MED CTR,NUCL MED SERV,FT GORDON,GA 30905. MED COLL GEORGIA,AUGUSTA,GA 30912. NR 0 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0363-9762 J9 CLIN NUCL MED JI Clin. Nucl. Med. PD OCT PY 1992 VL 17 IS 10 BP 827 EP 827 DI 10.1097/00003072-199210000-00019 PG 1 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA JT386 UT WOS:A1992JT38600019 PM 1424367 ER PT J AU PIRONNEAU, O LIOU, J TEZDUYAR, T AF PIRONNEAU, O LIOU, J TEZDUYAR, T TI CHARACTERISTIC-GALERKIN AND GALERKIN LEAST-SQUARES SPACE-TIME FORMULATIONS FOR THE ADVECTION-DIFFUSION EQUATION WITH TIME-DEPENDENT DOMAINS SO COMPUTER METHODS IN APPLIED MECHANICS AND ENGINEERING LA English DT Article ID NAVIER-STOKES EQUATIONS; FINITE-ELEMENT; CONVERGENCE AB For the advection-diffusion equation, the characteristic-Galerkin formulations are obtained by temporal discretization of the total derivative. These formulations, by construction, are Eulerian-Lagrangian, and therefore can handle time-dependent domains without difficulty. The Galerkin/least-squares space-time formulation, on the other hand, is written over the space-time domain of a problem, and therefore can handle time-dependent domains with no implementational difficulty. The purpose of this paper is to compare these two formulations based on error estimates and numerical performance, in the context of the advection-diffusion equation. C1 UNIV MINNESOTA,ARMY HIGH PERFORMANCE COMP RES CTR,DEPT AEROSP ENGN & MECH,MINNEAPOLIS,MN 55455. UNIV MINNESOTA,MINNESOTA SUPERCOMP INST,MINNEAPOLIS,MN 55455. RP PIRONNEAU, O (reprint author), UNIV PARIS 06,ANAL NUMER,T 55-65-5,4 PL JUSSIEU,F-75005 PARIS,FRANCE. RI Tezduyar, Tayfun/F-6134-2012 OI Tezduyar, Tayfun/0000-0001-8707-3162 NR 21 TC 44 Z9 46 U1 0 U2 0 PU ELSEVIER SCIENCE SA LAUSANNE PI LAUSANNE 1 PA PO BOX 564, 1001 LAUSANNE 1, SWITZERLAND SN 0045-7825 J9 COMPUT METHOD APPL M JI Comput. Meth. Appl. Mech. Eng. PD OCT PY 1992 VL 100 IS 1 BP 117 EP 141 DI 10.1016/0045-7825(92)90116-2 PG 25 WC Engineering, Multidisciplinary; Mathematics, Interdisciplinary Applications; Mechanics SC Engineering; Mathematics; Mechanics GA JR850 UT WOS:A1992JR85000005 ER PT J AU WATT, G AF WATT, G TI LEPTOSPIROSIS SO CURRENT OPINION IN INFECTIOUS DISEASES LA English DT Article AB Recent reports on leptospirosis have focused on its epidemiology, clinical manifestations, and diagnosis. The disease continues to be a major public health problem in the tropics, as evidenced by several recent reports from India and the Caribbean. In the United Kingdom, leptospirosis cases predominate in agricultural workers, while recreational exposure and household pets are important sources of infection in the United States. Several recent clinical reports emphasize that severe pulmonary involvement can complicate leptospirosis. Another investigation concerned a group of adult patients with pancreatitis, previously thought to occur mainly in children. Current methods of diagnosis are clearly unsatisfactory, but much research activity is directed at improving this situation. These are grounds for optimism that better diagnostic tests will be available in the near future. RP WATT, G (reprint author), ARMED FORCES RES INST MED SCI,DEPT MED,APO AP 96546,BANGKOK,THAILAND. NR 0 TC 8 Z9 8 U1 1 U2 2 PU RAPID SCIENCE PUBLISHERS PI LONDON PA 2-6 BOUNDARY ROW, LONDON, ENGLAND SE1 8NH SN 0951-7375 J9 CURR OPIN INFECT DIS JI Curr. Opin. Infect. Dis. PD OCT PY 1992 VL 5 IS 5 BP 659 EP 663 PG 5 WC Infectious Diseases SC Infectious Diseases GA JQ594 UT WOS:A1992JQ59400006 ER PT J AU TANDHANANDBANCHUIN, N KESPICHAYAWATANA, W VANNASAENG, S BANCHUIN, C LAOHAPAND, T PANPIMARNMAS, S PATTANAPANYASAT, K SARASOMBATH, S WEBSTER, HK AF TANDHANANDBANCHUIN, N KESPICHAYAWATANA, W VANNASAENG, S BANCHUIN, C LAOHAPAND, T PANPIMARNMAS, S PATTANAPANYASAT, K SARASOMBATH, S WEBSTER, HK TI PRESENCE OF AUTOIMMUNITY TO PANCREATIC ANTIGENS IN A PATIENT WITH FIBROCALCULOUS PANCREATIC DIABETES SO DIABETES RESEARCH AND CLINICAL PRACTICE LA English DT Article DE ISLET CELL ANTIBODIES (ICA); LYMPHOPROLIFERATION ASSAY; PANCREATIC ANTIGEN; FIBROCALCULOUS PANCREATIC DIABETES (FCPD); CD8+ LYMPHOCYTES-T ID MELLITUS AB A case of fibrocalculous pancreatic diabetes (FCPD) is reported for which antibody and cellular immune characteristics were determined. The patient, a Thai woman, had serum islet cell antibodies (ICA) that were detected by both immunoperoxidase staining and an indirect enzyme-linked immunosorbent assay (ELISA). Serum anti-human insulin antibodies were negative by a displacement ELISA. Lymphoproliferation assay against pancreatic antigen prepared from a blood group O cadaveric donor was positive. Increased CD8+ lymphocytes were observed using direct immunofluorescence staining and flow cytometry. CD4+ T lymphocytes, B lymphocytes and NK cells were within normal levels. These findings provide evidence for autoimmunity to pancreatic antigens in a patient with fibrocalculous pancreatic diabetes. C1 SIRIRAJ HOSP,FAC MED,DEPT MED,BANGKOK 10700,THAILAND. MAHIDOL UNIV,FAC GRAD STUDIES,BANGKOK 10700,THAILAND. MINIST PUBL HLTH,RAJAVITHI HOSP,DEPT SURG,BANGKOK,THAILAND. ARMED FORCES RES INST MED SCI,DEPT IMMUNOL,BANGKOK,THAILAND. RP TANDHANANDBANCHUIN, N (reprint author), SIRIRAJ HOSP,FAC MED,DEPT MICROBIOL,DIV IMMUNOL,BANGKOK 10700,THAILAND. NR 21 TC 8 Z9 8 U1 0 U2 0 PU ELSEVIER SCI IRELAND LTD PI CLARE PA CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE, IRELAND SN 0168-8227 J9 DIABETES RES CLIN PR JI Diabetes Res. Clin. Pract. PD OCT PY 1992 VL 18 IS 1 BP 17 EP 21 DI 10.1016/0168-8227(92)90050-2 PG 5 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA JU278 UT WOS:A1992JU27800003 PM 1446574 ER PT J AU SMALLRIDGE, RC KIANG, JG GIST, ID FEIN, HG GALLOWAY, RJ AF SMALLRIDGE, RC KIANG, JG GIST, ID FEIN, HG GALLOWAY, RJ TI U-73122, AN AMINOSTEROID PHOSPHOLIPASE-C ANTAGONIST, NONCOMPETITIVELY INHIBITS THYROTROPIN-RELEASING-HORMONE EFFECTS IN GH3 RAT PITUITARY-CELLS SO ENDOCRINOLOGY LA English DT Article ID PROTEIN-KINASE-C; POLYMORPHONUCLEAR NEUTROPHILS; CYTOPLASMIC CALCIUM; DEPENDENT PROCESSES; CA-2+; ACCUMULATION; HYDROLYSIS; ELEVATION; SECRETION; POLYPHOSPHOINOSITIDES AB TRH increases cytosolic-free calcium ([Ca2+]i) by activating phospholipase C(PL-C), which induces phosphoinositol hydrolysis, leading to Ca2+ mobilization from inositol trisphosphate (IP3) sensitive stores, and by increasing Ca2+ influx. Increases in [Ca2+]i stimulate PRL secretion. We investigated the effects of U-73122, an aminosteroid inhibitor of PL-C dependent processes, on TRH-stimutated second messenger pathways and on PRL secretion in GH3 rat pituitary cells. [Ca2+]i was monitored by Indo-1 fluorescence, and IP3 and metabolites separated on ion exchange columns. In Ca2+-free buffer, [Ca2+]i was 96 +/- 6 nm and increased to 323 +/- 23 nm (P < 0.001) after TRH (100 nm). U-73122 dose dependently inhibited the TRH effect (IC50 = 967 nm; complete inhibition at 3-5 mum). Subsequent addition of monensin (100 mum) increased [Ca2+]i from 107 +/- 4 to 142 +/- 4 nm (P < 0.001), confirming our previous findings of a non-TRH regulated Ca2+ pool in GH3 cells. Pretreatment (15 sec) with U-73122 partly inhibited the TRH effect on [Ca2+]i; Complete suppression occurred with 70 sec of pretreatment. An inactive analog (U-73343) had no inhibitory effect at 5 mum. U-73122 acted noncompetitively, as the mean maximum velocity (expressed as percent increase in [Ca2+]i after TRH) was reduced from 225 to 91 while the Michaelis-Menten constant for TRH was unchanged (15.4 vs. 13.8 nm, n = 3). Of note, U-73122, at 3-5 muM, increased basal [Ca2+]i from 109 +/- 5 to 120 +/- 5 nm (P < 0.001). In 1.3 mm Ca2+ buffer containing nifedipine (1 mum) and verapamil (50 mum), similar effects of U-73122 (5 mum) were observed on basal and TRH-stimulated [Ca2+]i. IP3, IP2, and IP1 increased to 241 +/- 12%, 148 +/- 23%, and 167 +/- 39% of control, 30 sec after TRH (100 nm); these responses were prevented by 1 mum U-73122. At 5 mum, U-73122 also significantly increased IP3 levels. TRH (100 nM) increased 4-h PRL secretion from 16.3 +/- 1.4 to 27.6 +/- 3.2 ng/well (P < 0.05). U-73122 (5 mum) increased basal PRL secretion to 35.9 +/- 3.2 ng/well (P < 0.05), but abolished the TRH effect. In contrast, U-73343 (with Ca2+ channel blockers) did not inhibit the TRH effect on PRL (control: 24.3 +/- 2.1; TRH: 51.0 +/- 6.3 ng/well). Conclusion: U-73122 is a potent inhibitor of TRH stimulated IP3 production, intracellular Ca2+ mobilization, and PRL secretion, and is a useful tool for studying PL-C mediated processes in GH3 cells. RP SMALLRIDGE, RC (reprint author), WALTER REED ARMY MED CTR, DEPT CLIN PHYSIOL, DIV MED, WASHINGTON, DC 20307 USA. NR 22 TC 141 Z9 142 U1 0 U2 0 PU ENDOCRINE SOC PI CHEVY CHASE PA 8401 CONNECTICUT AVE, SUITE 900, CHEVY CHASE, MD 20815-5817 USA SN 0013-7227 EI 1945-7170 J9 ENDOCRINOLOGY JI Endocrinology PD OCT PY 1992 VL 131 IS 4 BP 1883 EP 1888 DI 10.1210/en.131.4.1883 PG 6 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA JT904 UT WOS:A1992JT90400048 PM 1396332 ER PT J AU HEWITT, AD MIYARES, PH LEGGETT, DC JENKINS, TF AF HEWITT, AD MIYARES, PH LEGGETT, DC JENKINS, TF TI COMPARISON OF ANALYTICAL METHODS FOR DETERMINATION OF VOLATILE ORGANIC-COMPOUNDS IN SOILS SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID SORPTION; WATER; TRICHLOROETHENE; CONTAMINANTS; POLLUTANTS AB This study compares aqueous extraction headspace/gas chromatography and purge-and-trap gas chromatography/mass spectrometry (EPA SW-846, method 8240) for the determination of four volatile organic compounds (VOCs) in soil. Comparisons were performed on two fortified soils and two soils obtained from sites where hazardous waste had been spilled or disposed. In only two of the cases studied were significant differences consistently found; for the two most hydrophobic compounds in a high organic carbon soil and for TCE in a field-contaminated soil that had previously shown slow aqueous VOC desorption. Our findings strongly suggest that aqueous extraction/headspace GC using a portable instrument can be used to screen soils on site for VOCs, providing rapid same-day results, that will consistently identify the presence of these analytes and provide quantitative results which are generally not significantly different from slower more expensive, laboratory-based purge-and-trap analysis. RP HEWITT, AD (reprint author), USA,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 29 TC 36 Z9 44 U1 1 U2 7 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0013-936X J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD OCT PY 1992 VL 26 IS 10 BP 1932 EP 1938 DI 10.1021/es00034a008 PG 7 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA JR074 UT WOS:A1992JR07400018 ER PT J AU LI, QG HUMPEL, M AF LI, QG HUMPEL, M TI PHARMACOKINETICS, HYDROLYSIS AND AROMATIZATION OF NORETHISTERONE-3-OXIME IN FEMALE CYNOMOLGUS MONKEY SO EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS LA English DT Article DE NORETHISTERONE-3-OXIME; PHARMACOKINETICS; HYDROLYSIS; AROMATIZATION; CYNOMOLGUS MONKEY ID NORETHINDRONE; AROMATIZATION; PROGESTOGENS; STEROIDS; RABBIT; RAT AB Norethisterone-3-oxime (NETO) was administered to 3 female cynomolgus monkeys intragastrically and, after a wash-out period of 2-5 weeks, intravenously at a dose of 1 mg/kg. The radioactive dose of tritiated NETO was 20 muCi/kg for both treatments. For i.v. injection, a 30% propylene glycol/water solution and for i.g. administration an aqueous microcrystalline suspension was used. Excretion of radiolabel in urine and feces was followed for 5 days and plasma samples were obtained up to 2 days after administrations. In all samples (urine, feces and plasma) radioactivity was determined. Extracts from plasma samples were subjected to HPLC separation of drug and metabolites, as well as NETO and NET (metabolite of NETO after hydrolysis of the oxime group) levels were determined. In addition, EE2 (ethinylestradiol, A-ring aromatised metabolite of NET) levels were estimated using a specifically designed HPLC system for separation. Quantification of EE2 was achieved by radioimmunoassay (RIA) of specific eluate fractions. The results demonstrate that [H-3]-NETO was absorbed completely at a dose level of 1 mg/kg, and excreted predominantly via the kidneys. A urinary to fecal excretion ratio of 1.5 (i.v.) or 1.0 (i.g.) was found. Renal excretion of total radiolabel proceeded with a half-life, of about 0.8 (i.v.) or 1.1 (i.g.) days. Balances were incomplete, probably due to technical reasons. Orally administered NETO was highly bioavailable (84.0 +/- 16.9% of dose) but rapidly cleared from plasma (total clearance corresponded to 97% of plasma liver flow). The clearance from plasma is equivalent to the metabolic clearance because almost no unchanged NETO is excreted. Extensive metabolism of the parent drug was observed leading to at least two pharmacologically active metabolites (NET, EE2). The main progestogenic metabolite was NET reaching similar high plasma levels as NETO. EE2 turned out to be a metabolite of NETO and a conversion rate of below 0.5% of dose was estimated. However, due to its high estrogenic potency EE2 might contribute to the overall pharmacological pattern of NETO in the cynomolgus monkey. C1 SCHERING AG,INST PHARMACOKINET,BERLIN BERGKAMM,GERMANY. RP LI, QG (reprint author), WALTER REED ARMY INST RES,DEPT ANAT,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307, USA. NR 43 TC 9 Z9 9 U1 0 U2 2 PU MEDECINE ET HYGIENE PI GENEVA 4 PA 78 AVE ROSERALE, 1211 GENEVA 4, SWITZERLAND SN 0378-7966 J9 EUR J DRUG METAB PH JI Eur. J. Drug Metabol. Pharmacokinet. PD OCT-DEC PY 1992 VL 17 IS 4 BP 281 EP 291 PG 11 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA KW783 UT WOS:A1992KW78300008 PM 1301358 ER PT J AU SANDSTROM, G SJOSTEDT, A JOHANSSON, T KUOPPA, K WILLIAMS, JC AF SANDSTROM, G SJOSTEDT, A JOHANSSON, T KUOPPA, K WILLIAMS, JC TI IMMUNOGENICITY AND TOXICITY OF LIPOPOLYSACCHARIDE FROM FRANCISELLA-TULARENSIS LVS SO FEMS MICROBIOLOGY IMMUNOLOGY LA English DT Article DE LIPOPOLYSACCHARIDE; TULAREMIA; FRANCISELLA-TULARENSIS; ENDOTOXIN; TNF; IL-1 ID TUMOR NECROSIS FACTOR; MONOCLONAL-ANTIBODIES; OUTER-MEMBRANE; ENDOTOXIN; INTERLEUKIN-1; HETEROGENEITY; PURIFICATION; LYMPHOCYTES; TULAREMIA; PROTEINS AB Lipopolysaccharide (LPS) from the live vaccine strain of Francisella tularensis (F. tularensis LVS) was isolated and purified. The LPS did not stimulate lymphocytes from previously tularaemia-vaccinated individuals or lymphocytes from non-primed individuals. However, serum antibodies from tularaemia vaccinees reacted with the LPS whereas virtually no reactivity was found with antibodies from individuals not exposed to F. tularensis LVS. Antibodies of immunoglobulin class M displayed the antibody reactivity predominantly. The LPS failed to induce the mononuclear cell-derived cytokine interleukin-1 and only low levels of tumour necrosis factor were detected. Furthermore, no LPS endotoxin properties were found in galactosamine-treated mice or in the Limulus amoebocyte lysate assay. From these results it can be concluded that F. tularensis LVS possesses a lipopolysaccharide-like molecule, which does not exhibit properties of a classical endotoxin. C1 US FDA, CTR BIOL EVALUAT & RES, BETHESDA, MD 20014 USA. UMEA UNIV, DEPT INFECT DIS, S-90187 UMEA, SWEDEN. USA, MED RES INST INFECT DIS, INTRACELLULAR PATHOGENS BRANCH, FREDERICK, MD 21701 USA. RP SANDSTROM, G (reprint author), NATL DEF RES ESTAB, DIV MICROBIOL, S-90182 UMEA, SWEDEN. NR 52 TC 29 Z9 32 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0920-8534 J9 FEMS MICROBIOL IMMUN PD OCT PY 1992 VL 105 IS 4 BP 201 EP 210 DI 10.1111/j.1574-6968.1992.tb05902.x PG 10 WC Immunology; Microbiology SC Immunology; Microbiology GA JV997 UT WOS:A1992JV99700005 ER PT J AU SJOGREN, R SHEADONOHUE, T COLLETON, C PINEIROCARRERO, V AF SJOGREN, R SHEADONOHUE, T COLLETON, C PINEIROCARRERO, V TI STEREOTYPED, LEUKOTRIENE SENSITIVE, MYOELECTRIC RESPONSE TO ACUTE ENTERIC INFLAMMATION SO GASTROENTEROLOGY LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,DEPT MED,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT PATHOL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT PEDIAT,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,SCH MED,BETHESDA,MD 20814. NR 0 TC 1 Z9 1 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0016-5085 J9 GASTROENTEROLOGY JI Gastroenterology PD OCT PY 1992 VL 103 IS 4 BP 1388 EP 1388 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA JQ502 UT WOS:A1992JQ50200100 ER PT J AU SIMMS, JE MORGAN, FD AF SIMMS, JE MORGAN, FD TI COMPARISON OF 4 LEAST-SQUARES INVERSION SCHEMES FOR STUDYING EQUIVALENCE IN ONE-DIMENSIONAL RESISTIVITY INTERPRETATION SO GEOPHYSICS LA English DT Article ID SOUNDINGS AB The problem of equivalence in dc resistivity inversion is well known. The ability to invert resistivity data successfully depends on the uniqueness of the model as well as the robustness of the inversion algorithm. To study the problems of model uniqueness and resolution, theoretical data are inverted using variations of a nonlinear least-squares inversion. It is only through model studies such as this one, where the true solutions are known, that realistic and meaningful comparisons of inversion methods can be undertaken. The data are inverted using three schemes of fixed-layer thickness where only the resistivity varies, and the results are compared to the variable parameter inversion where both the layer resistivities and thicknesses are allowed to vary. The purpose of fixing the layer thicknesses is to reduce the number of parameters solved for during the inversion process. By doing this, nonuniqueness may be reduced. The fixed-layer thickness schemes are uniform thickness, geometrical progression of thickness, and logarithmic progression of thickness. By applying each inversion scheme to different models, the layer thickness that minimizes the data rms error for various numbers of layers is determined. The curve of data rms error versus model rms error consists of three general regions: unique, nonunique, and no resolution. A good inversion routine simultaneously minimizes the data rms and model rms errors. The variable parameter scheme is best at simultaneously minimizing the data rms and model rms errors for models that can be resolved through the inversion process. The optimum number of layers in the model can be determined by using a modified F-test. RP SIMMS, JE (reprint author), USAE WATERWAYS EXPT STN,VICKSBURG,MS 39180, USA. NR 28 TC 12 Z9 13 U1 0 U2 0 PU SOC EXPLORATION GEOPHYSICISTS PI TULSA PA 8801 S YALE ST, TULSA, OK 74137 SN 0016-8033 J9 GEOPHYSICS JI Geophysics PD OCT PY 1992 VL 57 IS 10 BP 1282 EP 1293 DI 10.1190/1.1443196 PG 12 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA JR481 UT WOS:A1992JR48100003 ER PT J AU MCGOVERN, TW HOLTZMULLER, KC SMITH, MA SHERMAN, K KEPCZYK, T MORRIS, E HEMING, P WONG, R MURPHY, J SJOGREN, MH AF MCGOVERN, TW HOLTZMULLER, KC SMITH, MA SHERMAN, K KEPCZYK, T MORRIS, E HEMING, P WONG, R MURPHY, J SJOGREN, MH TI HEPATITIS-C TRANSMISSION IN SEXUAL BUT NOT IN CASUAL CONTACTS OF INDEX CASES SO HEPATOLOGY LA English DT Meeting Abstract C1 USA,MED RES INST INFECT DIS,FREDERICK,MD 21701. TRIPLER ARMY MED CTR,HONOLULU,HI 96859. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. FITZSIMONS ARMY MED CTR,AURORA,CO 80045. BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0270-9139 J9 HEPATOLOGY JI Hepatology PD OCT PY 1992 VL 16 IS 4 BP A72 EP A72 PN 2 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA JR380 UT WOS:A1992JR38000109 ER PT J AU KLEGKA, J DRIELS, M AF KLEGKA, J DRIELS, M TI ANALYSIS OF A CONCEPTUAL AUTOMATED REWORK FACILITY FOR PRINTED WIRING ASSEMBLY MANUFACTURING SYSTEMS SO IEEE TRANSACTIONS ON COMPONENTS HYBRIDS AND MANUFACTURING TECHNOLOGY LA English DT Article AB In this paper an analysis of a conceptual automated rework facility for use in a printed wiring assembly (PWA) manufacturing system is presented. The current manual rework system is considered as well as a conceptual automated rework facility. The total cost of rework is decomposed into a diagnostic cost and a rework cost. The reduction of this total cost is the goal of the automated facility. C1 USN,POSTGRAD SCH,DEPT MECH ENGN,MONTEREY,CA 93943. RP KLEGKA, J (reprint author), US MIL ACAD,DEPT CIVIL & MECH ENGN,W POINT,NY 10996, USA. NR 38 TC 0 Z9 0 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0148-6411 J9 IEEE T COMPON HYBR PD OCT PY 1992 VL 15 IS 5 BP 876 EP 883 DI 10.1109/33.180054 PG 8 WC Engineering, Manufacturing; Engineering, Electrical & Electronic; Materials Science, Multidisciplinary SC Engineering; Materials Science GA KD698 UT WOS:A1992KD69800033 ER PT J AU LIESKE, CN GROSS, CL AF LIESKE, CN GROSS, CL TI ANTIBODIES TO SULFUR MUSTARD - REPLY SO IMMUNOLOGY LETTERS LA English DT Letter RP LIESKE, CN (reprint author), USA,MRICD,ABERDEEN PROVING GROUND,MD 21010, USA. NR 5 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-2478 J9 IMMUNOL LETT JI Immunol. Lett. PD OCT-NOV PY 1992 VL 34 IS 2 BP 175 EP 176 DI 10.1016/0165-2478(92)90245-J PG 2 WC Immunology SC Immunology GA JY680 UT WOS:A1992JY68000013 ER PT J AU REEVES, JT MAZZEO, RS WOLFEL, EE YOUNG, AJ AF REEVES, JT MAZZEO, RS WOLFEL, EE YOUNG, AJ TI INCREASED ARTERIAL-PRESSURE AFTER ACCLIMATIZATION TO 4300-M - POSSIBLE ROLE OF NOREPINEPHRINE SO INTERNATIONAL JOURNAL OF SPORTS MEDICINE LA English DT Article; Proceedings Paper CT SESSION ON PHYSIOLOGY OF MOUNTAIN SPORTS, AT THE INTERNATIONAL CONGRESS ON MOUNTAIN SPORTS CY FEB 02-04, 1992 CL CHAMONIX, FRANCE DE ALTITUDE; SYMPATHETIC ACTIVITY; ALPHA-ADRENERGIC ACTIVITY ID HIGH-ALTITUDE; CHRONIC HYPOXIA; OXYGEN-TRANSPORT; EXERCISE; PROPRANOLOL; RESPONSES AB Both systemic arterial pressure and sympathetic activity increase at high altitude, but neither the time course of these increases nor the relationship between them are known. Examination of resting and exercising data from our prior studies at sea level and on Pikes Peak indicated that blood epinephrine concentrations either showed little change (from sea level) or rose early in altitude exposure and then declined with acclimatization. By contrast, norepinephrine concentrations in blood and urine were not increased on arrival but consistently rose later in the acclimatization process. Also with altitude exposure, arterial pressure also increased concomitantly with the increase in norepinephrine concentrations. The study designs were not adequate to establish cause and effect, but the results were consistent with the concept that arterial pressure increments at altitude were associated with increased alpha adrenergic-mediated vascular tone. C1 UNIV COLORADO,DEPT KINESIOL,BOULDER,CO 80309. USA,ENVIRONM MED RES INST,DIV MIL ERGON,NATICK,MA 01760. RP REEVES, JT (reprint author), UNIV COLORADO,HLTH SCI CTR,DIV CARDIOL,CUP RES LAB B-133,DENVER,CO 80262, USA. FU NHLBI NIH HHS [HL-14985, HL-17731] NR 14 TC 30 Z9 30 U1 0 U2 1 PU GEORG THIEME VERLAG PI STUTTGART PA P O BOX 30 11 20, D-70451 STUTTGART, GERMANY SN 0172-4622 J9 INT J SPORTS MED JI Int. J. Sports Med. PD OCT PY 1992 VL 13 SU 1 BP S18 EP S21 DI 10.1055/s-2007-1024581 PG 4 WC Sport Sciences SC Sport Sciences GA JX592 UT WOS:A1992JX59200005 PM 1483768 ER PT J AU SUTTON, JR REEVES, JT GROVES, BM WAGNER, PD ALEXANDER, JK HULTGREN, HN CYMERMAN, A HOUSTON, CS AF SUTTON, JR REEVES, JT GROVES, BM WAGNER, PD ALEXANDER, JK HULTGREN, HN CYMERMAN, A HOUSTON, CS TI OXYGEN-TRANSPORT AND CARDIOVASCULAR FUNCTION AT EXTREME ALTITUDE - LESSONS FROM OPERATION EVEREST-II SO INTERNATIONAL JOURNAL OF SPORTS MEDICINE LA English DT Article; Proceedings Paper CT SESSION ON PHYSIOLOGY OF MOUNTAIN SPORTS, AT THE INTERNATIONAL CONGRESS ON MOUNTAIN SPORTS CY FEB 02-04, 1992 CL CHAMONIX, FRANCE DE ALTITUDE; EXERCISE; CARDIAC OUTPUT; HYPOBARIC CHAMBER; PULMONARY CIRCULATION ID MT EVEREST; SIMULATED ALTITUDE; EXERCISE; MUSCLE; ASCENT AB Operation Everest II was designed to examine the physiological responses to gradual decompression simulating an ascent of Mt Everest (8,848 m) to an inspired PO2 of 43 mmHg. The principal studies conducted were cardiovascular, respiratory, muscular-skeletal and metabolic responses to exercise. Eight healthy males aged 21-31 years began the "ascent" and six successfully reached the "summit", where their resting arterial blood gasses were PO2 = 30 mmHg and PCO2 = 11 mmHg, pH = 7.56. Their maximal oxygen uptake decreased from 3.98 +/- 0.2 L/min at sea level to 1.17 +/- 0.08 L/min at PIO2 43 mmHg. The principal factors responsible for oxygen transport from the atmosphere to tissues were (1) Alveolar ventilation - a four fold increase. (2) Diffusion from the alveolus to end capillary blood - unchanged. (3) Cardiac function (assessed by hemodynamics, echocardiography and electrocardiography) - normal - although maximum cardiac output and heart rate were reduced. (4) Oxygen extraction - maximal with PvO2 14.8 +/- 1 mmHg. With increasing altitude maximal blood and muscle lactate Progressively declined although at any submaximal intensity blood and muscle lactate was higher at higher altitudes. C1 UNIV COLORADO,DEPT MED,BOULDER,CO 80309. BAYLOR COLL MED,DEPT INTERNAL MED,HOUSTON,TX 77030. USA,ENVIRONM MED RES INST,DIV ALTITUDE RES,NATICK,MA 01760. UNIV CALIF SAN DIEGO,DEPT MED,LA JOLLA,CA 92093. VET ADM MED CTR,DEPT CARDIOL,PALO ALTO,CA 94304. UNIV VERMONT,DEPT MED,BURLINGTON,VT 05401. RP SUTTON, JR (reprint author), UNIV SYDNEY,FAC HLTH SCI,DEPT BIOL SCI,POB 170,LIDCOMBE,NSW 2141,AUSTRALIA. NR 17 TC 15 Z9 16 U1 0 U2 3 PU GEORG THIEME VERLAG PI STUTTGART PA P O BOX 30 11 20, D-70451 STUTTGART, GERMANY SN 0172-4622 J9 INT J SPORTS MED JI Int. J. Sports Med. PD OCT PY 1992 VL 13 SU 1 BP S13 EP S18 DI 10.1055/s-2007-1024580 PG 6 WC Sport Sciences SC Sport Sciences GA JX592 UT WOS:A1992JX59200004 PM 1483751 ER PT J AU HAO, OJ PHULL, KK SIMMERS, KW AF HAO, OJ PHULL, KK SIMMERS, KW TI LABORATORY EVALUATION OF THE LEACHING OF ORGANICS FROM FABRIC MATERIAL SO JOURNAL AMERICAN WATER WORKS ASSOCIATION LA English DT Article ID POLYVINYL-CHLORIDE PIPE; VINYL-CHLORIDE; DRINKING-WATER; TETRACHLOROETHYLENE; MIGRATION AB Samples of fabrics made for collapsible potable water storage tanks by five manufacturers were used to evaluate leaching of organics under three test conditions: control medium (pH = 8.3) at 20-degrees-C; low-pH medium (pH = 5.8, Cl2 = 10 mg/L); and control medium at 50-degrees-C. The extraction procedures were basically those described in National Sanitation Foundation standard 61. Results indicated the presence of trace amounts of organic compounds, but the concentrations were well below existing health standards. The type and magnitude of the organics depended on the material used and the test conditions. C1 USA,ENVIRONM HYG AGCY,DIV WATER QUAL ENGN,ABERDEEN PROVING GROUND,MD 21010. RP HAO, OJ (reprint author), UNIV MARYLAND,DEPT CIVIL ENGN,COLL PK,MD 20742, USA. NR 34 TC 1 Z9 1 U1 0 U2 2 PU AMER WATER WORKS ASSOC PI DENVER PA 6666 W QUINCY AVE, DENVER, CO 80235 SN 0003-150X J9 J AM WATER WORKS ASS JI J. Am. Water Work Assoc. PD OCT PY 1992 VL 84 IS 10 BP 92 EP 98 PG 7 WC Engineering, Civil; Water Resources SC Engineering; Water Resources GA JT701 UT WOS:A1992JT70100017 ER PT J AU STAFFORD, CT WISE, SL ROBINSON, DA CROSBY, BL HOFFMAN, DR AF STAFFORD, CT WISE, SL ROBINSON, DA CROSBY, BL HOFFMAN, DR TI SAFETY AND EFFICACY OF FIRE ANT VENOM IN THE DIAGNOSIS OF FIRE ANT ALLERGY SO JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY LA English DT Article DE SOLENOPSIS-INVICTA; VENOM; WHOLE BODY EXTRACT; DIAGNOSIS; FIRE ANT ALLERGY ID HUMAN IMMUNE RESPONSIVENESS; WHOLE-BODY EXTRACTS; HYMENOPTERA VENOM; SOLENOPSIS-INVICTA; INDUSTRIAL-POPULATION; HYPERSENSITIVITY; IMMUNOTHERAPY; SENSITIVITY; INVIVO AB Thirty-three adult patients who had had systemic allergic reactions to fire ant stings and 33 insect-nonallergic control subjects were skin tested with single lots of Solenopsis invicta (Sol i) fire ant venom (IFAV) and two commercially available imported fire ant whole body extracts (IFA WBEs). All three extracts were analyzed for protein concentration. Sol i II and Sol i III concentrations were each assayed by means of two ELISAs with complementary monoclonal antibodies, one species specific and one cross-reactive. Radioallergosorbent test (RAST) to IFAV and both IFA WBEs was performed on sera from all study subjects. Both IFA WBEs contained high concentrations of fire ant body proteins. Sol i II and III concentrations each varied twofold between the two IFA WBE preparations. Patients were generally more reactive to IFAV than IFA WBE by skin testing and RAST. IFAV RAST appeared to be a more sensitive assay than IFA WBE RAST. No adverse reactions occurred to skin testing with IFAV, but intradermal testing with higher concentrations of IFA WBE caused delayed large local reactions in 16 of 30 (53%) control subjects. These reactions were attributed to the large amounts of extraneous body proteins in IFA WBE. These results (1) demonstrate that skin testing with IFAV is safe, (2) indicate that IFAV is more potent than IFA WBE, and (3) suggest that IFAV may be the superior reagent for diagnosis of fire ant allergy. C1 USA,EISENHOWER MED CTR,FT GORDON,GA 30905. E CAROLINA UNIV,SCH MED,GREENVILLE,NC 27834. RP STAFFORD, CT (reprint author), MED COLL GEORGIA,BG 248,AUGUSTA,GA 30912, USA. NR 33 TC 16 Z9 17 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0091-6749 J9 J ALLERGY CLIN IMMUN JI J. Allergy Clin. Immunol. PD OCT PY 1992 VL 90 IS 4 BP 653 EP 661 DI 10.1016/0091-6749(92)90139-S PN 1 PG 9 WC Allergy; Immunology SC Allergy; Immunology GA JT995 UT WOS:A1992JT99500012 PM 1401645 ER PT J AU CHYLEK, P DAMIANO, P NGO, D PINNICK, RG AF CHYLEK, P DAMIANO, P NGO, D PINNICK, RG TI POLYNOMIAL-APPROXIMATION OF THE OPTICAL-PROPERTIES OF WATER CLOUDS IN THE 8-12-MU-M SPECTRAL REGION SO JOURNAL OF APPLIED METEOROLOGY LA English DT Note ID EXTINCTION; ABSORPTION; CLIMATE; FOGS AB We have developed a simple approximation for the absorption, extinction and scattering coefficients, infrared emittance, single-scattering albedo, and asymmetry factor of water clouds within the 8-12-mum spectral region. The aforementioned cloud-scattering characteristics are obtained as continuous functions of the wavelength lambda, liquid water content W, effective radius r(eff), and effective variance upsilon(eff) of the droplet-size distribution. The accuracy of the proposed approximation ip shown to be within 6% for most types of water clouds when compared to the exact Mie theory calculation and integration over the size distribution. At the same time the required computer time is reduced by a factor of 10(2)-10(3). C1 SUNY ALBANY,ATMOSPHER SCI RES CTR,ALBANY,NY 12222. SUNY ALBANY,DEPT ATMOSPHER SCI,ALBANY,NY 12222. NEW MEXICO STATE UNIV,DEPT PHYS,LAS CRUCES,NM 88003. ATMOSPHER SCI LAB,WHITE SANDS MISSILE RANGE,NM. RP CHYLEK, P (reprint author), DALHOUSIE UNIV,DEPT PHYS & OCEANOG,ATMOSPHER SCI PROGRAM,HALIFAX B3H 3J5,NS,CANADA. NR 17 TC 6 Z9 6 U1 0 U2 2 PU AMER METEOROLOGICAL SOC PI BOSTON PA 45 BEACON ST, BOSTON, MA 02108-3693 SN 0894-8763 J9 J APPL METEOROL JI J. Appl. Meteorol. PD OCT PY 1992 VL 31 IS 10 BP 1210 EP 1218 PG 9 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA JQ078 UT WOS:A1992JQ07800007 ER PT J AU CASSADAY, M KADAKIA, SC YAMAMOTO, K PARKER, A AF CASSADAY, M KADAKIA, SC YAMAMOTO, K PARKER, A TI FOLEY FEEDING CATHETER MIGRATION INTO THE SMALL-BOWEL SO JOURNAL OF CLINICAL GASTROENTEROLOGY LA English DT Article DE PERCUTANEOUS ENDOSCOPIC GASTROSTOMY (PEG); PERCUTANEOUS ENDOSCOPIC JEJUNOSTOMY (PEJ); ENDOSCOPY; ENTERAL NUTRITION; COMPLICATION OF GASTROSTOMY ID GASTROSTOMY TUBE; DUODENAL OBSTRUCTION; REPLACEMENT AB Percutaneous endoscopic gastrostomy provides a nonsurgical alternative to enteral feeding. The tube may deteriorate or be expelled accidentally from the stomach and require replacement. We report a patient in whom the replacement Foley catheter migrated into the jejunum, resulting in impaction of the hub into the abdominal wall with resultant localized infection and impaction at the stoma site. We review this problem and suggest a simple technique to prevent the complication. C1 BROOKE ARMY MED CTR,DEPT MED,GASTROENTEROL SERV,FT SAM HOUSTON,TX 78234. NR 13 TC 4 Z9 4 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0192-0790 J9 J CLIN GASTROENTEROL JI J. Clin. Gastroenterol. PD OCT PY 1992 VL 15 IS 3 BP 242 EP 244 DI 10.1097/00004836-199210000-00015 PG 3 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA JR561 UT WOS:A1992JR56100014 PM 1479171 ER PT J AU MCCARROLL, JE URSANO, RJ FULLERTON, CS WRIGHT, KM AF MCCARROLL, JE URSANO, RJ FULLERTON, CS WRIGHT, KM TI COMMUNITY CONSULTATION FOLLOWING A MAJOR AIR DISASTER SO JOURNAL OF COMMUNITY PSYCHOLOGY LA English DT Article AB United Airlines flight 232 crashed at Sioux City, Iowa, on July 19, 1989. The primary rescue workers were the men and women from the 185th Air National Guard Group. Because of the many deaths and massive destruction caused by the crash, a psychiatric consultation team was requested by the U.S. Air Force Surgeon General to assist the Air National Guard personnel. The consultation had four goals: (1) provide consultation to the Air National Guard on the mental health of the community; (2) provide direct psychiatric services on an acute basis and referral for follow-up care, if necessary; (3) train mental health personnel as consultants following disasters; and (4) develop and implement a research plan that would address both the immediate and long-term health consequences of the rescue work. The consultation included community-oriented interventions directed toward reducing the effects of psychological stress on high-risk groups. This paper describes the consultations and the 1-year follow-up. C1 UNIFORMED SERV UNIV HLTH SCI,F EDWARD HEBERT SCH MED,BETHESDA,MD 20814. RP MCCARROLL, JE (reprint author), WALTER REED ARMY INST RES,DEPT MIL PSYCHIAT,WASHINGTON,DC 20307, USA. NR 9 TC 2 Z9 2 U1 0 U2 1 PU CLINICAL PSYCHOLOGY PUBL CO PI BRANDON PA 4 CONANT SQUARE, BRANDON, VT 05733 SN 0090-4392 J9 J COMMUNITY PSYCHOL JI J. Community Psychol. PD OCT PY 1992 VL 20 IS 4 BP 271 EP 275 DI 10.1002/1520-6629(199210)20:4<271::AID-JCOP2290200402>3.0.CO;2-Q PG 5 WC Public, Environmental & Occupational Health; Psychology, Multidisciplinary; Social Work SC Public, Environmental & Occupational Health; Psychology; Social Work GA JW523 UT WOS:A1992JW52300001 ER PT J AU SAU, P LUPTON, GP GRAHAM, JH AF SAU, P LUPTON, GP GRAHAM, JH TI TRICHOGERMINOMA - REPORT OF 14 CASES SO JOURNAL OF CUTANEOUS PATHOLOGY LA English DT Article ID GIANT SOLITARY TRICHOEPITHELIOMA; TRICHOBLASTIC FIBROMA; HAIR GERM; TUMORS AB We report 14 cases of trichogerminoma, a rare form of cutaneous adnexal neoplasm, derived from hair germ epithelium. The neoplasms occurred in 9 men and 5 women. Their ages ranged from 16 to 73 years (median 53 years). The tumors were slow growing, asymptomatic dermal or subcutaneous nodules, located on the head and neck (6), trunk (4), extremities (2) and hip (1), with no distinguishing clinical features. Histologically, trichogerminomas were characterized by sharply circumscribed, pseudoencapsulated dermal and subcutaneous nodules, ranging in size from 0.4 to 4.0 cm in diameter (mean 1.9 cm). The nodules were subdivided into lobules separated by variable amounts of stroma that demonstrated varying cellularity and mucin content. The lobules were composed of basaloid cells that formed densely packed, round nests or "cell balls" resembling hair bulbs. The basaloid cells demonstrated peripheral palisading, keratinization and differentiation towards various pilosebaceous structures. Retraction spaces, well developed hair follicles and hair shafts were not observed. These distinctive histologic features separated these neoplasms from other tumors of pilar origin and from basal cell carcinoma. The trichogerminomas behaved in a benign fashion with one exception. Complete excision of the lesions is the treatment of choice. C1 WALTER REED ARMY MED CTR,DEPT PATHOL,WASHINGTON,DC 20307. ARMED FORCES INST PATHOL,WASHINGTON,DC 20306. SCRIPPS CLIN & RES FDN,DEPT PATHOL,DIV DERMATOPATHOL,LA JOLLA,CA 92037. RP SAU, P (reprint author), WALTER REED ARMY MED CTR,DEPT DERMATOL,WASHINGTON,DC 20307, USA. NR 18 TC 28 Z9 29 U1 0 U2 0 PU MUNKSGAARD INT PUBL LTD PI COPENHAGEN PA 35 NORRE SOGADE, PO BOX 2148, DK-1016 COPENHAGEN, DENMARK SN 0303-6987 J9 J CUTAN PATHOL JI J. Cutan. Pathol. PD OCT PY 1992 VL 19 IS 5 BP 357 EP 365 DI 10.1111/j.1600-0560.1992.tb00606.x PG 9 WC Dermatology; Pathology SC Dermatology; Pathology GA JW080 UT WOS:A1992JW08000002 PM 1282133 ER PT J AU MCMULLEN, R AF MCMULLEN, R TI AFRICAN ECONOMIC-REFORM - THE EXTERNAL DIMENSION - LANCASTER,C SO JOURNAL OF DEVELOPING AREAS LA English DT Book Review RP MCMULLEN, R (reprint author), US MIL ACAD,W POINT,NY 10996, USA. NR 1 TC 0 Z9 0 U1 0 U2 1 PU WESTERN ILLINOIS UNIV PI MACOMB PA 1 UNIV CIRCLE, MACOMB, IL 61455-1390 SN 0022-037X J9 J DEV AREAS JI J. Dev. Areas PD OCT PY 1992 VL 27 IS 1 BP 95 EP 96 PG 2 WC Area Studies; Economics; Planning & Development; Political Science SC Area Studies; Business & Economics; Public Administration; Government & Law GA KE874 UT WOS:A1992KE87400011 ER PT J AU BAISDEN, MK KULILD, JC WELLER, RN AF BAISDEN, MK KULILD, JC WELLER, RN TI ROOT-CANAL CONFIGURATION OF THE MANDIBULAR 1ST PREMOLAR SO JOURNAL OF ENDODONTICS LA English DT Article AB One hundred six human mandibular left and right first premolars, previously extracted due to nonrestorable caries, periodontal disease, or orthodontic reasons, were sectioned perpendicular to the long axis of the root starting at the cementoenamel junction. Three-millimeter sections were made with an ultrathin separating disc to the level of the anatomical apex. After 1 day in 5.25% NaOCl, each section was rinsed in phosphate-buffered saline, evaluated with a stereomicroscope, and photographed. The slides were projected and the shape of the canal, incidence of multiple canals, level of bifurcation, and any other variant anatomy were recorded. Seventy-six percent of the premolars demonstrated Type I canals and 24% contained Type IV. The shape of the canals was predominantly oval or round. An interesting finding was the number of C-shaped canals which were associated predominantly with Type IV canal systems. This occurred in 14% of the roots. C1 USA,DENT ACTIV,POSTGRAD PROGRAM,ENDODONT RESIDENCY PROGRAM,FT GORDON,GA 30905. RP KULILD, JC (reprint author), USA,DENT ACTIV,POSTGRAD PROGRAM,ENDODONT RESIDENCY PROGRAM,FT GORDON,GA 30905, USA. NR 12 TC 48 Z9 53 U1 1 U2 2 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0099-2399 J9 J ENDODONT JI J. Endod. PD OCT PY 1992 VL 18 IS 10 BP 505 EP 508 DI 10.1016/S0099-2399(06)81352-X PG 4 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA KC863 UT WOS:A1992KC86300008 PM 1289476 ER PT J AU WHITE, CS AF WHITE, CS TI AN ANALYSIS OF THE THIN-WALLED TORSION SPECIMEN SO JOURNAL OF ENGINEERING MATERIALS AND TECHNOLOGY-TRANSACTIONS OF THE ASME LA English DT Article ID PLASTIC-DEFORMATION AB A detailed finite element analysis has been conducted of the thin-walled torsion specimen. This specimen, when properly gripped, provides an approximation to the simple shear deformation field. Variations through the thickness of the specimen are small for the shear stress but can be large for the axial normal stress. Plastic deformation extends into the shoulder region requiring a correction factor to be used when converting the applied twist at the grips to average shear strain across the gauge section. This correction factor can be numerically quantified and used in data reduction. RP USA, MAT TECHNOL LAB, MAT DYNAM BRANCH, WATERTOWN, MA 02172 USA. NR 21 TC 4 Z9 4 U1 0 U2 0 PU ASME PI NEW YORK PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA SN 0094-4289 EI 1528-8889 J9 J ENG MATER-T ASME JI J. Eng. Mater. Technol.-Trans. ASME PD OCT PY 1992 VL 114 IS 4 BP 384 EP 389 DI 10.1115/1.2904189 PG 6 WC Engineering, Mechanical; Materials Science, Multidisciplinary SC Engineering; Materials Science GA JU981 UT WOS:A1992JU98100007 ER PT J AU OCKENHOUSE, CF TEGOSHI, T MAENO, Y BENJAMIN, C HO, M KAN, KE THWAY, Y WIN, K AIKAWA, M LOBB, RR AF OCKENHOUSE, CF TEGOSHI, T MAENO, Y BENJAMIN, C HO, M KAN, KE THWAY, Y WIN, K AIKAWA, M LOBB, RR TI HUMAN VASCULAR ENDOTHELIAL-CELL ADHESION RECEPTORS FOR PLASMODIUM-FALCIPARUM INFECTED ERYTHROCYTES - ROLES FOR ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE-1 AND VASCULAR CELL-ADHESION MOLECULE-1 SO JOURNAL OF EXPERIMENTAL MEDICINE LA English DT Article ID TUMOR-NECROSIS-FACTOR; SOLUBLE FORM; FUNCTIONAL-CHARACTERIZATION; PARASITIZED ERYTHROCYTES; MEMBRANE GLYCOPROTEIN; MALARIA; ICAM-1; EXPRESSION; CLONING; BINDING AB The clinical complications associated with severe and cerebral malaria occur as a result of the intravascular mechanical obstruction of erythrocytes infected with the asexual stages of the parasite, Plasmodium falciparum. We now report that a primary P. falciparum-infected erythrocyte (parasitized red blood cell [PRBC]) isolate from a patient with severe complicated malaria binds to cytokine-induced human vascular endothelial cells, and that this adhesion is in part mediated by endothelial leukocyte adhesion molecule 1 (ELAM-1) and vascular cell adhesion molecule 1 (VCAM-1). PRBC binding to tumor necrosis factor alpha (TNF-alpha-activated human vascular endothelial cells is partially inhibited by antibodies to ELAM-1 and ICAM-1 and the inhibitory effects of these antibodies is additive. PRBCs selected in vitro by sequential panning on purified adhesion molecules bind concurrently to recombinant soluble ELAM-1 and VCAM-1, and to two previously identified endothelial cell receptors for PRBCs, ICAM-1, and CD36. Post-mortem brain tissue from patients who died from cerebral malaria expressed multiple cell adhesion molecules including ELAM-1 and VCAM-1 on cerebral microvascular endothelium not expressed in brains of individuals who died from other causes. These results ascribe novel pathological functions for both ELAM-1 and VCAM-1 and may help delineate alternative adhesion pathways PRBCs use to modify malaria pathology. C1 UNIV CALGARY,DEPT MICROBIOL & INFECT DIS,CALGARY T2N 4N1,ALBERTA,CANADA. MAHIDOL UNIV,HOSP TROP DIS,BANGKOK 10400,THAILAND. DEPT MED RES,YANGON,MYANMAR. MIL HOSP 2,YANGON,MYANMAR. CASE WESTERN RESERVE UNIV,SCH MED,INST PATHOL,CLEVELAND,OH 44106. BIOGEN INC,CAMBRIDGE,MA 02142. RP OCKENHOUSE, CF (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,IMMUNOL BRANCH,WASHINGTON,DC 20307, USA. FU NIAID NIH HHS [AI-10645] NR 40 TC 303 Z9 304 U1 1 U2 4 PU ROCKEFELLER UNIV PRESS PI NEW YORK PA 1114 FIRST AVE, 4TH FL, NEW YORK, NY 10021 SN 0022-1007 J9 J EXP MED JI J. Exp. Med. PD OCT 1 PY 1992 VL 176 IS 4 BP 1183 EP 1189 DI 10.1084/jem.176.4.1183 PG 7 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA JP862 UT WOS:A1992JP86200027 PM 1383378 ER PT J AU CASTRO, CA LARSEN, T AF CASTRO, CA LARSEN, T TI PRIMACY AND RECENCY EFFECTS IN NONHUMAN-PRIMATES SO JOURNAL OF EXPERIMENTAL PSYCHOLOGY-ANIMAL BEHAVIOR PROCESSES LA English DT Article ID SERIAL-POSITION CURVES; MONKEY LIST MEMORY; SHORT-TERM-MEMORY; RHESUS-MONKEY; FREE-RECALL; RECOGNITION; RATS; ASSOCIATIONS; HIPPOCAMPUS; ACQUISITION AB The reports of primacy and recency memory effects in nonhuman primates have been criticized because they have all used an initiating response. That is, the presentation of the to-be-remembered list of items was always contingent on a response being initiated by the nonhuman primate. It has been argued that this initiating response improves performance for early items in the list, resulting in the occurrence of the primacy effect, independent of any memory processing mechanism. This criticism was addressed in the present study by not using an initiating response prior to the presentation of the list. Nevertheless, both a primacy and a recency effect were observed in all 6 rhesus monkeys evaluated using a serial probe recognition task. Thus, the results are similar to those for humans, in that both primacy and recency effects can be obtained in nonhuman primates. A brief literature review is included, and it is proposed that the primacy and recency effects observed in humans, nonhuman primates, and infraprimates can be explained within the context of the configural-association theory. RP CASTRO, CA (reprint author), USA,DIV DRUG ASSESSMENT,ADV ASSESSMENT BRANCH,EDGEWOOD AREA,ABERDEEN PROVING GROUND,MD 21010, USA. NR 41 TC 27 Z9 27 U1 2 U2 4 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 SN 0097-7403 J9 J EXP PSYCHOL ANIM B JI J. Exp. Psychol.-Anim. Behav. Process. PD OCT PY 1992 VL 18 IS 4 BP 335 EP 340 DI 10.1037//0097-7403.18.4.335 PG 6 WC Psychology, Biological; Behavioral Sciences; Psychology; Psychology, Experimental; Zoology SC Psychology; Behavioral Sciences; Zoology GA JR181 UT WOS:A1992JR18100002 PM 1402692 ER PT J AU MUNAVALLI, S ROSSMAN, DI ROHRBAUGH, DK FERGUSON, CP SZAFRANIEC, LJ AF MUNAVALLI, S ROSSMAN, DI ROHRBAUGH, DK FERGUSON, CP SZAFRANIEC, LJ TI SIMULTANEOUS SCISSION OF C-S AND S-S BONDS OF BIS(TRIFLUOROMETHYL)TRISULFIDE BY GRIGNARD-REAGENTS SO JOURNAL OF FLUORINE CHEMISTRY LA English DT Article ID UNSYMMETRICAL DIALKYL DISULFIDES; VOLATILE FLAVOR COMPONENTS; ALKYL; MECHANISM; MAGNESIUM; RADICALS; KINETICS; SULFIDES; SURFACE; SULFUR AB Trifluoromethyl mono-, di- and tri-sulfides, and alkyl sulfides and disulfides, as well as dimerized products, are formed as a result of the simultaneous cleavage of the C-S and S-S bonds of bis(trifluoromethyl)trisulfide by Grignard reagents at - 78-degrees-C. The formation of various products has been rationalized on the basis of the involvement of free radicals. C1 USA,CTR CHEM RES DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010. RP MUNAVALLI, S (reprint author), GEOCTR,FT WASHINGTON,MD 20744, USA. NR 46 TC 30 Z9 30 U1 0 U2 4 PU ELSEVIER SCIENCE SA LAUSANNE PI LAUSANNE 1 PA PO BOX 564, 1001 LAUSANNE 1, SWITZERLAND SN 0022-1139 J9 J FLUORINE CHEM JI J. Fluor. Chem. PD OCT PY 1992 VL 59 IS 1 BP 91 EP 99 DI 10.1016/S0022-1139(00)80206-7 PG 9 WC Chemistry, Inorganic & Nuclear; Chemistry, Organic SC Chemistry GA JW938 UT WOS:A1992JW93800010 ER PT J AU WESTERINK, JJ LUETTICH, RA BAPTISTA, AM SCHEFFNER, NW FARRAR, P AF WESTERINK, JJ LUETTICH, RA BAPTISTA, AM SCHEFFNER, NW FARRAR, P TI TIDE AND STORM-SURGE PREDICTIONS USING FINITE-ELEMENT MODEL SO JOURNAL OF HYDRAULIC ENGINEERING-ASCE LA English DT Article ID SHALLOW-WATER EQUATIONS; ENGLISH-CHANNEL; NORTH-SEA; COMPUTATIONS; BIGHT AB A finite element (FE) model is used to study tides and hurricane storm surge in the Gulf of Mexico in the region ranging from the Mississippi Sound to the northwest coast of Florida. Issues that arc emphasized include the use of large domains, the importance ot a high degree of grid resolution in coastal regions of interest, the use of meshes with highly varying nodal densities to minimize the size of the discrete problem, and the use of the generalized wave-continuity equation (GWCE) for FE-based solutions to the shallow-water equations. The computations presented are unprecedented in their scope, level of localized detail, and degree of grid-size variability. The GWCE-based FE model leads to very accurate and efficient flow solutions. C1 UNIV N CAROLINA,INST MARINE SCI,MOREHEAD CITY,NC 28557. OREGON GRAD INST,DEPT ENVIRONM SCI,BEAVERTON,OR 97006. USA,ENGRS WTRWAYS EXPTL STN,VICKSBURG,MS 39180. USN,OFF OCEANG,DEPT OCEANG,BAY ST LOUIS,MS 39522. RP WESTERINK, JJ (reprint author), UNIV NOTRE DAME,DEPT CIVIL ENGN & GEOL SCI,NOTRE DAME,IN 46556, USA. NR 29 TC 74 Z9 75 U1 3 U2 10 PU ASCE-AMER SOC CIVIL ENGINEERS PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-9429 J9 J HYDRAUL ENG-ASCE JI J. Hydraul. Eng.-ASCE PD OCT PY 1992 VL 118 IS 10 BP 1373 EP 1390 DI 10.1061/(ASCE)0733-9429(1992)118:10(1373) PG 18 WC Engineering, Civil; Engineering, Mechanical; Water Resources SC Engineering; Water Resources GA JP190 UT WOS:A1992JP19000003 ER PT J AU FISHERHOCH, SP BRAMMER, TL TRAPPIER, SG HUTWAGNER, LC FARRAR, BB RUO, SL BROWN, BG HERMANN, LM PEREZORONOZ, GI GOLDSMITH, CS HANES, MA MCCORMICK, JB AF FISHERHOCH, SP BRAMMER, TL TRAPPIER, SG HUTWAGNER, LC FARRAR, BB RUO, SL BROWN, BG HERMANN, LM PEREZORONOZ, GI GOLDSMITH, CS HANES, MA MCCORMICK, JB TI PATHOGENIC POTENTIAL OF FILOVIRUSES - ROLE OF GEOGRAPHIC ORIGIN OF PRIMATE HOST AND VIRUS-STRAIN SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID HEMORRHAGIC-FEVER; EBOLA VIRUS; INFECTION; ZAIRE AB African filoviruses have caused outbreaks of fulminating hemorrhagic fever among humans. In 1989, related filoviruses were isolated from cynomolgus monkeys imported into the United States from the Philippines. The pathogenic potential of these new filoviruses was compared in 16 Asian monkeys (Macaca fascicularis-cynomolgus) and 16 African monkeys (Cercopithecus aethiops-African green) using African filoviruses from Zaire (Ebola virus) and Sudan or Asian filoviruses (Reston and Pennsylvania). African filovirus infections resulted in earlier death (P = .005), had a shorter duration of disease and median incubation period (3-4 vs. 7 days), and had earlier peak viremia (5-7 vs. 7-9 days). African green monkeys showed significantly higher survival than cynomolgus monkeys (P < .01), and some were asymptomatic as have been humans accidentally infected with Asian filovirus. Rechallenge experiments showed that protection in survivors of filovirus infections against fatal challenge with Ebola (Zaire) virus is unpredictable. The minimal clinical disease observed in humans infected with the Reston strain is consistent with host- and virus-dependent pathogenicity. C1 CTR DIS CONTROL,NATL CTR INFECT DIS,RES ANIM SECT,SPECIAL PATHOL GENS BRANCH,ATLANTA,GA 30333. CTR DIS CONTROL,NATL CTR INFECT DIS,SCI RESOURCES PROGRAM,ANIM RESOURCES BRANCH,ATLANTA,GA 30333. CTR DIS CONTROL,NATL CTR INFECT DIS,DIV VIRAL & RICKETTSIAL DIS,ATLANTA,GA 30333. USA,MED RES INST INFECT DIS,DIV PATHOL,FREDERICK,MD 21701. RP FISHERHOCH, SP (reprint author), CTR DIS CONTROL,NATL CTR INFECT DIS,DIV BACTERIAL & MYCOT DIS,ATLANTA,GA 30333, USA. NR 23 TC 104 Z9 110 U1 2 U2 9 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD OCT PY 1992 VL 166 IS 4 BP 753 EP 763 PG 11 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA JP645 UT WOS:A1992JP64500009 PM 1527410 ER PT J AU KRAKAUER, T SNOUWAERT, JN FOWLKES, DM KRAKAUER, H AF KRAKAUER, T SNOUWAERT, JN FOWLKES, DM KRAKAUER, H TI ANALYSIS OF THE HETEROGENEITY OF THE BIOLOGICAL RESPONSES TO NATIVE AND MUTANT HUMAN INTERLEUKIN-6 SO JOURNAL OF LEUKOCYTE BIOLOGY LA English DT Article DE BIOACTIVITY; BIOASSAY; INTERLEUKIN-6 ID HYBRIDOMA GROWTH-FACTOR; AMINO-ACID-SEQUENCE; ESCHERICHIA-COLI; HUMAN IL-6; EXPRESSION; CYTOKINES; MONOCYTES; RECEPTORS; CELLS AB The structure-function relationships of the biological activities of mutant varieties of the pleiotropic cytokine interleukin-6 (human) were measured by three assays: induction of immunoglobulin M (IgM) secretion from an Epstein-Barr virus-transformed human B cell line and induction of fibrinogen secretion from either a human hepatoma cell line or a rat hepatoma cell line. The biological effects of the cytokine were characterized by three parameters as determined by a novel analysis: effectiveness (the maximal response attainable), efficiency (the concentration yielding a half-maximal response), and complexity (a measure of heterogeneity and feedback control). Substitution of serine for cysteine was associated with a reduction in the effectiveness of interleukin-6 in both fibrinogen secretion assays. In the assay with human hepatoma cells, there was also a profound reduction in efficiency. Serine substitution in the human IgM synthesis assay appears mainly to reduce the efficiency. Deletion of amino acids 4 to 23 increased the efficiency in the rat hepatoma assay. The complexity parameter suggests the presence of multiple receptor classes or negative feedback in all three assays. Use of the proposed sequential approach to the analysis of dose-response relations in bioassays provides a more useful quantitative assessment of activities as well as more insight into the complexity of the reactions. C1 UNIV N CAROLINA,SCH MED,DEPT PATHOL,CHAPEL HILL,NC 27514. HLTH CARE FINANCING ADM,BALTIMORE,MD. RP KRAKAUER, T (reprint author), USA,MED RES INST INFECT DIS,DIV DIS ASSESSMENT,BLDG 1425,FREDERICK,MD 20702, USA. NR 23 TC 2 Z9 2 U1 1 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0741-5400 J9 J LEUKOCYTE BIOL JI J. Leukoc. Biol. PD OCT PY 1992 VL 52 IS 4 BP 415 EP 420 PG 6 WC Cell Biology; Hematology; Immunology SC Cell Biology; Hematology; Immunology GA JR768 UT WOS:A1992JR76800009 PM 1328443 ER PT J AU AVSICZUPANC, T XIAO, SY STOJANOVIC, R GLIGIC, A VANDERGROEN, G LEDUC, JW AF AVSICZUPANC, T XIAO, SY STOJANOVIC, R GLIGIC, A VANDERGROEN, G LEDUC, JW TI CHARACTERIZATION OF DOBRAVA VIRUS - A HANTAVIRUS FROM SLOVENIA, YUGOSLAVIA SO JOURNAL OF MEDICAL VIROLOGY LA English DT Article DE HEMORRHAGIC FEVER WITH RENAL SYNDROME (HFRS); VIRUS ISOLATION; POLYMERASE CHAIN REACTION (PCR); RESTRICTION FRAGMENT LENGTH POLYMORPHISM (RFLP); DOBRAVA VIRUS ID HEMORRHAGIC-FEVER; RENAL SYNDROME; RNA AB Small mammals were collected in natural foci of hemorrhagic fever with renal syndrome (HFRS) in Slovenia, Yugoslavia, and a hantavirus was isolated from the lungs of an Apodemus flavicollis captured in Dobrava village. This new isolate, Dobrava virus, was compared with representative strains of the Hantavirus genus by serological and polymerase chain reaction-restriction, fragment length polymorphism (PCR-RFLP) methods. It was found by cross immunofluorescent and enzyme-linked immunosorbent assays that antigenic properties of Dobrava virus were different from those of other hantaviruses. The RNA of this virus was successfully amplified with hantavirus genus reactive primer sets by reverse transcriptase polymerase chain reaction (RT-PCR); however, PCR-RFLP analysis of the amplified product was shown to be unique among those of the known hantaviruses, further indicating that Dobrava virus represents a new hantavirus serotype. C1 USA,MED RES INST INFECT DIS,DIV DIS ASSESSMENT,FREDERICK,MD 21702. INST IMMUNOL & VIROL,BELGRADE,YUGOSLAVIA. EDVARD KARDELJ UNIV,INST MICROBIOL,YU-61105 LJUBLJANA,YUGOSLAVIA. MIL MED ACAD,BELGRADE,YUGOSLAVIA. INST TROP MED PRINCE LEOPOLD,B-2000 ANTWERP,BELGIUM. RI Xiao, Shu-Yuan/E-2215-2012 NR 18 TC 165 Z9 168 U1 0 U2 6 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0146-6615 J9 J MED VIROL JI J. Med. Virol. PD OCT PY 1992 VL 38 IS 2 BP 132 EP 137 DI 10.1002/jmv.1890380211 PG 6 WC Virology SC Virology GA JR630 UT WOS:A1992JR63000010 PM 1360999 ER PT J AU GLANTZ, DM AF GLANTZ, DM TI THE GHOSTS OF DEMIANSK, IN MEMORY OF THE SOLDIERS OF THE SOVIET 1ST AIRBORNE CORPS SO JOURNAL OF MILITARY HISTORY LA English DT Article RP GLANTZ, DM (reprint author), US ARMY,FOREIGN MIL STUDIES OFF,COMBINED ARMS COMMAND,FT LEAVENWORTH,KS, USA. NR 19 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD OCT PY 1992 VL 56 IS 4 BP 617 EP 650 DI 10.2307/1986164 PG 34 WC History SC History GA JR553 UT WOS:A1992JR55300004 ER PT J AU DOUGHTY, RA AF DOUGHTY, RA TI 3 MARSHALS OF FRANCE - LEADERSHIP AFTER TRAUMA - CLAYTON,A SO JOURNAL OF MILITARY HISTORY LA English DT Book Review RP DOUGHTY, RA (reprint author), US MIL ACAD,W POINT,NY 10996, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD OCT PY 1992 VL 56 IS 4 BP 716 EP 717 DI 10.2307/1986193 PG 2 WC History SC History GA JR553 UT WOS:A1992JR55300035 ER PT J AU HOFFMAN, MA JOHNSON, CL MOORE, T PEARL, RH AF HOFFMAN, MA JOHNSON, CL MOORE, T PEARL, RH TI MANAGEMENT OF CATASTROPHIC NEONATAL MIDGUT VOLVULUS WITH A SILO AND 2ND-LOOK LAPAROTOMY SO JOURNAL OF PEDIATRIC SURGERY LA English DT Article; Proceedings Paper CT 23RD ANNUAL MEETING OF THE CANADIAN ASSOC OF PAEDIATRIC SURGEONS CY SEP 19-22, 1991 CL QUEBEC, CANADA SP CANADIAN ASSOC PAEDIAT SURGEONS DE MALROTATION; VOLVULUS, MIDGUT ID INTRA-ABDOMINAL PRESSURE; INTRAABDOMINAL PRESSURE C1 WALTER REED ARMY MED CTR,DEPT SURG,GEN SURG SERV,WASHINGTON,DC 20307. UNIV PENN,SCH MED,PHILADELPHIA,PA 19104. RP HOFFMAN, MA (reprint author), CHILDRENS HOSP PHILADELPHIA,DEPT SURG,34TH ST & CIV CTR BLVD,PHILADELPHIA,PA 19104, USA. NR 11 TC 5 Z9 5 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0022-3468 J9 J PEDIATR SURG JI J. Pediatr. Surg. PD OCT PY 1992 VL 27 IS 10 BP 1336 EP 1339 DI 10.1016/0022-3468(92)90291-E PG 4 WC Pediatrics; Surgery SC Pediatrics; Surgery GA JR780 UT WOS:A1992JR78000023 PM 1403516 ER PT J AU MCCOLLUM, J ONEAL, RB BRENNAN, WA VANDYKE, TE HORNER, JA AF MCCOLLUM, J ONEAL, RB BRENNAN, WA VANDYKE, TE HORNER, JA TI THE EFFECT OF TITANIUM IMPLANT ABUTMENT SURFACE IRREGULARITIES ON PLAQUE ACCUMULATION INVIVO SO JOURNAL OF PERIODONTOLOGY LA English DT Article DE DENTAL IMPLANTS; ABUTMENTS, DENTAL; TITANIUM; DENTAL PLAQUE PREVENTION; DENTAL PROPHYLAXIS METHODS ID PLASTIC INSTRUMENTS; EDENTULOUS PATIENTS; METAL AB THE PURPOSE OF THIS study was 2-fold to: 1) evaluate in vitro the surface texture of titanium implant abutments after exposure to plastic scalers, an air-powder abrasive system, rubber cup polishing with flour of pumice, and untreated control abutments; and 2) compare plaque accumulation in humans on abutments treated with the above methods. In part 1, 5.5 mm abutments were instrumented for 30 seconds per 90-degrees segment with the respective methods. The surface character was compared to untreated controls using SEM at 260X magnification. The control abutments revealed prominent milling marks and small pits; plastic scalers slightly smoothed the milling marks and created microscratches; the air-powder abrasive largely obliterated the milling marks and caused some surface pitting; the rubber cup with flour of pumice removed the milling marks and created a smooth swirl pattern. None of the instrumentation appeared to roughen the surface. In the clinical experiment (part II), four abutments, one of each type, were placed in 12 patients for a period of 7 days, during which the patients performed no oral hygiene. At the end of 7 days, the abutments were retrieved and processed for SEM. A digitizer and software program were used to determine the percent of total abutment surface area covered by plaque. The demarcation of supragingival and subgingival plaque was well delineated. The total mean percent surface area of plaque ranged from 52.06% for the air-powder abrasive to 55.29% for the plastic scalers. All abutments collected plaque, but no single treatment yielded a surface with significantly different amounts of plaque accumulation. For maintenance and prophylaxis, any of these methods may be used without damaging the abutment surface or enhancing plaque accumulation. The rubber cup with flour of pumice provides the smoothest polished abutment surface when used with light intermittent pressure. Heavy pressure with the rubber cup on an abutment may gouge the surface or round the abutment-prosthesis interface. C1 EASTMAN DENT CTR,ROCHESTER,NY 14620. DWIGHT D EISENHOWER ARMY MED CTR,DEPT CLIN INVEST,FT GORDON,GA 30905. RP MCCOLLUM, J (reprint author), USA,DENTAC,DEPT PERIODONT,PERIODONT RESIDENCY PROGRAM,FT GORDON,GA 30905, USA. NR 22 TC 47 Z9 48 U1 0 U2 0 PU AMER ACAD PERIODONTOLOGY PI CHICAGO PA 737 NORTH MICHIGAN AVENUE, SUITE 800, CHICAGO, IL 60611-2690 SN 0022-3492 J9 J PERIODONTOL JI J. Periodont. PD OCT PY 1992 VL 63 IS 10 BP 802 EP 805 PG 4 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA JU813 UT WOS:A1992JU81300002 PM 1403586 ER PT J AU KOSTKA, P AHMAD, S KWAN, CY DANIEL, EE GORDON, RK CHIANG, PK AF KOSTKA, P AHMAD, S KWAN, CY DANIEL, EE GORDON, RK CHIANG, PK TI PREJUNCTIONAL MUSCARINIC RECEPTORS IN THE DEEP MUSCULAR PLEXUS OF CANINE ILEUM - COMPARISON WITH SMOOTH-MUSCLE RECEPTORS SO JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS LA English DT Article ID MYENTERIC PLEXUS; BINDING-PROPERTIES; DOG ILEUM; ADENYLATE-CYCLASE; CEREBRAL-CORTEX; SMALL-INTESTINE; PAROTID-GLAND; ACETYLCHOLINE; ANTAGONISTS; SUBTYPES AB Prejunctional muscarinic receptors from the deep muscular plexus of canine ileum were studied, and their properties were compared with those of the postjunctional receptors of the circular smooth muscle. In the purified synaptosomal fraction (a fraction containing primarily the axonal varicosities of deep muscular plexus), the muscarinic ligand N-[H-3]methylscopolamine labeled an apparently homogenous population of receptors (n(H) = 1) with a K(d) of 2.7 nM and a B(max) of 195 +/- 44 fmol/mg protein (mean +/- S.D., n = 4). These receptors showed a high affinity for the M3/M1-selective antagonist 4-diphenylacetoxy-N-methylpiperidine methiodide (pK(i) = 7.41); in contrast, the pK(i) values of pirenzepine (5.60), methoctramine (5.65) and AF-DX 116 (5.21) implied little selectivity for these subtypes. The binding properties of muscarinic receptors in the synaptosomal fraction were different from the binding properties of muscarinic receptors in the purified circular smooth muscle plasma membranes. Most notably, the circular smooth muscle receptors had significantly lower affinity for N-[H-3]methylscopolamine (K(d) = 16 nM) with a B(max) value of 2088 +/- 276 fmol/mg. The affinities of the M2 subtype-selective muscarinic antagonists methoctramine and AF-DX 116 were similar in both membrane preparations. The receptor population associated with the deep muscular plexus synaptosomal fraction was linked to the inhibition of adenylate cyclase activity, as demonstrated by a concentration-dependent, atropine-sensitive inhibition of the forskolin-stimulated enzyme in the presence of muscarinic agonists carbachol and oxotremorine. Based on the pharmacological observations presented here, the prejunctional muscarinic receptors in the axonal varicosities of deep muscular plexus are different from the postjunctional receptors present in the circular smooth muscle. C1 WALTER REED ARMY MED CTR,DEPT APPL BIOCHEM,WASHINGTON,DC 20307. MCMASTER UNIV,DEPT BIOMED SCI,DIV PHYSIOL & PHARMACOL,HAMILTON L8S 4L8,ONTARIO,CANADA. NR 40 TC 9 Z9 9 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-3565 J9 J PHARMACOL EXP THER JI J. Pharmacol. Exp. Ther. PD OCT PY 1992 VL 263 IS 1 BP 226 EP 231 PG 6 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA JT987 UT WOS:A1992JT98700033 PM 1403787 ER PT J AU DRISCOLL, CF HUGHES, B OSTROWSKI, JS AF DRISCOLL, CF HUGHES, B OSTROWSKI, JS TI NATURALLY-OCCURRING UNDERCUTS IN THE RETENTION OF AN INTERIM OCULOFACIAL PROSTHESIS SO JOURNAL OF PROSTHETIC DENTISTRY LA English DT Article AB The use of adhesives in retaining maxillofacial prostheses bas been advocated and, applied for many years. Implant placement has reduced the need for adhesives in some patients but is impractical when ablative surgery is followed by radiation treatment. A technique is described that permits the rapid fabrication of an oculofacial prosthesis that uses naturally occurring orbital undercuts for retention, rather than adhesives that may further irritate radiated tissues. C1 USN,SCH DENT,BETHESDA,MD 20814. RP DRISCOLL, CF (reprint author), US DENTAC,TRIPLER ARMY MED CTR,HONOLULU,HI 96859, USA. NR 7 TC 1 Z9 1 U1 0 U2 2 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0022-3913 J9 J PROSTHET DENT JI J. Prosthet. Dent. PD OCT PY 1992 VL 68 IS 4 BP 652 EP 654 DI 10.1016/0022-3913(92)90382-K PG 3 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA JP877 UT WOS:A1992JP87700017 PM 1403945 ER PT J AU VANSUMMERS, W LEEK, MR AF VANSUMMERS, W LEEK, MR TI THE ROLE OF SPECTRAL AND TEMPORAL CUES IN VOWEL IDENTIFICATION BY LISTENERS WITH IMPAIRED HEARING SO JOURNAL OF SPEECH AND HEARING RESEARCH LA English DT Article DE SPEECH PERCEPTION; VOWEL IDENTIFICATION; HEARING IMPAIRMENT; FREQUENCY RESOLUTION; TEMPORAL RESOLUTION ID AUDITORY FILTER SHAPES; NOTCHED-NOISE DATA; SPEECH-PERCEPTION; 1ST FORMANT; FREQUENCY; RECOGNITION; DURATION; DERIVATION; RESOLUTION; ENGLISH AB This study examined the use of duration and formant frequency in the labeling of synthetic CVC stimuli forming a beet-bit continuum. Durational and F2 frequency cues to vowel identity varied systematically across stimuli. Subjects with normal hearing tended to rely primarily on F2 frequency in vowel labeling, whereas subjects with impaired hearing relied less on F2 information. This group difference was observed even for stimuli with large F2 differences, which were easily discriminated by all subjects. The effect of vowel duration on labeling was similar for both groups, with long-duration stimuli receiving more "beet" responses than short-duration stimuli across the F2 range. Psychoacoustic measures of frequency resolution and temporal resolution were poor predictors of a subject's use of formant information and duration information in labeling. RP VANSUMMERS, W (reprint author), WALTER REED ARMY MED CTR,CTR ARMY AUDIOL & SPEECH,WASHINGTON,DC 20307, USA. FU NIDCD NIH HHS [DC 00626] NR 44 TC 3 Z9 3 U1 0 U2 0 PU AMER SPEECH-LANGUAGE-HEARING ASSOC PI ROCKVILLE PA 10801 ROCKVILLE PIKE RD, ROCKVILLE, MD 20852-3279 SN 0022-4685 J9 J SPEECH HEAR RES JI J. Speech Hear. Res. PD OCT PY 1992 VL 35 IS 5 BP 1189 EP 1199 PG 11 WC Language & Linguistics; Rehabilitation SC Linguistics; Rehabilitation GA JR897 UT WOS:A1992JR89700025 PM 1447929 ER PT J AU VOGEL, PS JAMES, WD AF VOGEL, PS JAMES, WD TI LICHEN-PLANUS OF THE EYELID - AN UNUSUAL CLINICAL PRESENTATION SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Note RP VOGEL, PS (reprint author), WALTER REED ARMY MED CTR,DERMATOL SERV,WASHINGTON,DC 20307, USA. NR 7 TC 5 Z9 5 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD OCT PY 1992 VL 27 IS 4 BP 638 EP 639 DI 10.1016/S0190-9622(08)80209-5 PG 2 WC Dermatology SC Dermatology GA JP872 UT WOS:A1992JP87200029 PM 1401326 ER PT J AU HAM, JA AF HAM, JA TI FREQUENCY-DOMAIN FLIGHT TESTING AND ANALYSIS OF AN OH-58D HELICOPTER SO JOURNAL OF THE AMERICAN HELICOPTER SOCIETY LA English DT Article AB A demonstration of frequency domain flight testing techniques and analysis was performed on a U.S. Army OH-58D helicopter. The tests were conducted in support of the OH-58D Airworthiness and Flight Characteristics Evaluation and the Army's development and ongoing review of Aeronautical Design Standard, ADS-33C, Handling Qualities Requirements of Military Rotorcraft. Hover and forward flight (60 knots) condition tests were conducted in three flight hours by Army experimental test pilots. Bandwidth and phase delay parameters were determined from flight test data according to the definitions in the ADS-33C. A frequency response identification program (FRESPID) was used to derive the required parameters using a discretized fast-Fourier transform algorithm on input control deflections and integrated output airframe angular rates. A comparison was made between handling qualities ratings from airworthiness evaluations and the predicted handling qualities levels from ADS-33C using the derived bandwidth and phase delay. In general, there was excellent agreement, indicating the validity of the frequency-response concept for predicting handling qualities levels. RP HAM, JA (reprint author), USA,CTR AVIAT TECH TEST,FT RUCKER,AL 36360, USA. NR 14 TC 3 Z9 3 U1 0 U2 0 PU AMER HELICOPTER SOC INC PI ALEXANDRIA PA 217 N WASHINGTON ST, ALEXANDRIA, VA 22314 SN 0002-8711 J9 J AM HELICOPTER SOC JI J. Am. Helicopter Soc. PD OCT PY 1992 VL 37 IS 4 BP 16 EP 24 PG 9 WC Engineering, Aerospace SC Engineering GA JU678 UT WOS:A1992JU67800003 ER PT J AU MAZUMDER, MM HILL, SC BARBER, PW AF MAZUMDER, MM HILL, SC BARBER, PW TI MORPHOLOGY-DEPENDENT RESONANCES IN INHOMOGENEOUS SPHERES - COMPARISON OF THE LAYERED T-MATRIX METHOD AND THE TIME-INDEPENDENT PERTURBATION METHOD SO JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION LA English DT Article ID STIMULATED RAMAN-SCATTERING; PARTIAL-WAVE RESONANCES; DIELECTRIC SPHERES; MIE SCATTERING; ELECTROMAGNETIC SCATTERING; FLUORESCENCE EMISSION; RADIATION PRESSURE; OPTICAL LEVITATION; ELASTIC-SCATTERING; LIGHT-SCATTERING AB The resonance locations and quality factors (Qs) of morphology-dependent resonances in an inhomogeneous sphere with a small refractive-index perturbation are computed by using the T-matrix method for layered axisymmetric objects and a time-independent perturbation method. The resonance locations computed are similar. The changes in the Q computed with the two methods are typically within a factor of 2 or 3 of each other when the change from the unperturbed Q is less than 50%. For the type of perturbation that we consider here, an increase in the refractive index in a nonconcentric spherical region inside the larger sphere, the resonance frequencies always decrease, but the Q's decrease or increase depending on the unperturbed Q and the location and shape of the perturbation. The change in frequency and the change in Q depend on the overlap of the perturbation with the energy-density distribution of the morphology-dependent resonance. For the same overlap, the change in Q is much larger for higher-Q modes than for lower-Q modes. A refractive index perturbation that causes a relatively small change in Q may cause the resonance frequency of a high-Q MDR to shift by many linewidths. C1 USA,ATMOSPHER SCI LAB,WHITE SANDS MISSILE RANGE,NM 88002. CLARKSON UNIV,DEPT ELECT & COMP ENGN,POTSDAM,NY 13699. RP MAZUMDER, MM (reprint author), NEW MEXICO STATE UNIV,DEPT ELECT & COMP ENGN,LAS CRUCES,NM 88003, USA. NR 46 TC 28 Z9 28 U1 0 U2 1 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0740-3232 J9 J OPT SOC AM A JI J. Opt. Soc. Am. A-Opt. Image Sci. Vis. PD OCT PY 1992 VL 9 IS 10 BP 1844 EP 1853 DI 10.1364/JOSAA.9.001844 PG 10 WC Optics SC Optics GA JQ422 UT WOS:A1992JQ42200020 ER PT J AU WATSON, RA HARPER, BN AF WATSON, RA HARPER, BN TI PARATESTICULAR FIBROUS PSEUDOTUMOR IN A PATIENT WITH GORLIN SYNDROME - NEVOID BASAL-CELL CARCINOMA SYNDROME SO JOURNAL OF UROLOGY LA English DT Note DE BASAL CELL NEVUS SYNDROME; CARCINOMA, BASAL CELL; TESTICULAR NEOPLASMS; FIBROSIS AB An 18-year-old man with Gorlin's syndrome (the nevoid basal cell carcinoma syndrome) underwent excisional biopsy of a fibrous pseudotumor of the tunica vaginalis. Preoperative ultrasound confirmed the extraparenchymal nature of this paratesticular lesion, permitting a transscrotal approach. The pathophysiological considerations suggest that this finding (to our knowledge the first such case reported in association with Gorlin's syndrome) may be more than coincidental. C1 JOINT MIL MED COMMAND,BROOKE ARMY MED CTR,DEPT UROL,SAN ANTONIO,TX. JOINT MIL MED COMMAND,BROOKE ARMY MED CTR,DEPT PATHOL,SAN ANTONIO,TX. NR 15 TC 5 Z9 5 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-5347 J9 J UROLOGY JI J. Urol. PD OCT PY 1992 VL 148 IS 4 BP 1254 EP 1255 PG 2 WC Urology & Nephrology SC Urology & Nephrology GA JR030 UT WOS:A1992JR03000041 PM 1404648 ER PT J AU RACINE, CH WALSH, ME ROEBUCK, BD COLLINS, CM CALKINS, D REITSMA, L BUCHLI, P GOLDFARB, G AF RACINE, CH WALSH, ME ROEBUCK, BD COLLINS, CM CALKINS, D REITSMA, L BUCHLI, P GOLDFARB, G TI WHITE PHOSPHORUS POISONING OF WATERFOWL IN AN ALASKAN SALT-MARSH SO JOURNAL OF WILDLIFE DISEASES LA English DT Note DE WHITE PHOSPHORUS; WATERFOWL; MORTALITY; SALT MARSH; ALASKA; ANAS SPP; CYGNUS SPP AB The cause of the yearly death of an estimated 1,000 to 2,000 migrating dabbling ducks (Anas spp.) and 10 to 50 swans (Cygnus buccinator and C. columbianus) has remained a mystery for the last ten years in Eagle River Flats (ERF), a 1,000 ha estuarine salt marsh near Anchorage, Alaska, used for artillery training by the U.S. Army. We have gathered evidence that the cause of this mortality is the highly toxic, incendiary munition white phosphorus (P4). The symptoms of poisoning we observed in wild ducks included lethargy, repeated drinking, and head shaking and rolling. Death was preceded by convulsions. Farm-reared mallards dosed with white phosphorus showed nearly identical behavioral symptoms to those of wild ducks that became sick in ERF. White phosphorus does not occur in nature but was found in both the sediments where dabbling ducks and swans feed and in the gizzards of all carcasses collected in ERF. We hypothesize that feeding waterfowl are ingesting small particles of the highly toxic, incendiary munition P4 stored in the bottom anoxic sediments of shallow salt marsh ponds. C1 DARTMOUTH COLL,DEPT PHARMACOL & TOXICOL,HANOVER,NH 03755. RP RACINE, CH (reprint author), USA,COLD REG RES & ENGN LAB,HANOVER,NH 03755, USA. NR 6 TC 27 Z9 27 U1 0 U2 5 PU WILDLIFE DISEASE ASSN, INC PI LAWRENCE PA 810 EAST 10TH ST, LAWRENCE, KS 66044-8897 SN 0090-3558 J9 J WILDLIFE DIS JI J. Wildl. Dis. PD OCT PY 1992 VL 28 IS 4 BP 669 EP 673 PG 5 WC Veterinary Sciences SC Veterinary Sciences GA JX861 UT WOS:A1992JX86100029 PM 1474672 ER PT J AU MUNDIE, TG JANUSZKIEWICZ, AJ RIPPLE, GR AF MUNDIE, TG JANUSZKIEWICZ, AJ RIPPLE, GR TI EFFECTS OF EPINEPHRINE, PHENOXYBENZAMINE, AND PROPRANOLOL ON MAXIMAL EXERCISE IN SHEEP SO LABORATORY ANIMAL SCIENCE LA English DT Article ID LEFT-VENTRICULAR FUNCTION; ORAL PROPRANOLOL; RESPONSES; CATECHOLAMINES; CONSUMPTION; BLOCKADE AB The mixed adrenergic agonist, epinephrine (10 mug/kg, i.v.), the beta-adrenergic receptor antagonist, propranolol (0.2 mg/kg, i.v.), or the alpha-adrenergic receptor antagonist, phenoxybenzamine (1 mg/kg, i.v.), were administered to sheep immediately before maximal incremental exercise. The effects of each of these drugs on hemoglobin (Hb) concentration during maximal exercise and on maximal exercise performance were investigated. The maximal incremental exercise protocol began at 4.0 km/h and 0% grade and finished at 5.6 km/h and 12% grade, with speed or grade increases every 1.5 minutes. Maximal exercise in control (untreated) sheep caused a mean 42% increase in hematocrit and 44% increase in Hb. This exercise-induced increase in Hb was unaffected by propranolol but was partially blocked by phenoxybenzamine. Epinephrine caused an immediate increase in Hb which abated during the early minutes of exercise and then subsequently increased toward the end of the exercise challenge. Maximum oxygen consumption (Vo2) in control sheep was 47.6 +/- 6.7 ml/min per kilogram. Maximum Vo2 after epinephrine, 51.6 +/- 8.7 ml/min per kilogram, was not significantly different from control. Maximum Vo2 after propranolol and phenoxybenzamine, 35.4 +/- 15.3 and 40.8 +/- 8.2 ml/min per kilogram, respectively, were both significantly less than control exercise (P < 0.05). C1 WALTER REED ARMY INST RES,DIV MED,DEPT RESP RES,WASHINGTON,DC 20307. NR 23 TC 10 Z9 10 U1 0 U2 1 PU AMER ASSOC LABORATORY ANIMAL SCIENCE PI CORDOVA PA 70 TIMBERCREEK DR, SUITE 5, CORDOVA, TN 38018 SN 0023-6764 J9 LAB ANIM SCI JI Lab. Anim. Sci. PD OCT PY 1992 VL 42 IS 5 BP 486 EP 490 PG 5 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA JV915 UT WOS:A1992JV91500012 PM 1460849 ER PT J AU KAMO, R BRYZIK, W AF KAMO, R BRYZIK, W TI SOLID LUBRICANTS FOR AN ADIABATIC ENGINE SO LUBRICATION ENGINEERING LA English DT Article AB This paper presents a high temperature piston concept, whereby a conventional liquid lubricant in combination with a solid lubricant can potentially provide the total lubrication requirement at high temperatures. This concept utilizes a two-piece piston which consists of: 1) a low thermal conductivity piston crown which is lubricated by a solid lubricant piston ring and cylinder liner, and 2) a lower skirt section which is hydrodynamically lubricated by conventional liquid lubricant and conventional piston rings. This two-piece hybrid piston has been analyzed for functional operation using various solid liner materials. Analysis shows the combined effects of piston ring mass side angle groove relationship, location, face profile, tension, orifice area, and ring cross section on oil transport, blowby, and ring force between ring face and cylinder wall over the cycle. Solid lubricant cylinder and piston ring combinations investigated were NASA PS200 against Stellite 6B, chrome oxide against chrome oxide, and chrome oxide against Cu + LiF coating. The proposed hybrid design offers the potential of operation at over 427-degrees-C top ring reversal temperature without significant advances above conventional synthetic liquid lubrication. Moreover, it promotes an engine that operates with low fuel consumption and low emissions characteristics. C1 USA,TANK AUTOMOT,WARREN,MI. RP KAMO, R (reprint author), ADIABAT INC,COLUMBUS,IN, USA. NR 9 TC 3 Z9 3 U1 0 U2 0 PU SOC TRIBOLOGISTS & LUBRICATION ENGINEERS PI PARK RIDGE PA 838 BUSSE HIGHWAY, PARK RIDGE, IL 60068 SN 0024-7154 J9 LUBR ENG JI Lubric. Eng. PD OCT PY 1992 VL 48 IS 10 BP 809 EP 815 PG 7 WC Engineering, Mechanical SC Engineering GA JT369 UT WOS:A1992JT36900005 ER PT J AU HOCK, VF SETLIFF, LF AF HOCK, VF SETLIFF, LF TI USING OFF POTENTIAL MEASURING DEVICES FOR UNDERGROUND STEEL TANKS SO MATERIALS PERFORMANCE LA English DT Article AB "Instant-off" potential (IOP) measurements allow the polarized potential of a cathodically protected structure to be determined. Potentials obtained using two commercially available devices for measuring IOP's were compared in the field to readings obtained using a recording oscilloscope and a digital voltmeter. Test data including waveform analysis for a cathodically protected underground storage tank is presented. RP HOCK, VF (reprint author), USA,CONSTRUCT ENGN RES LAB,POB 9005,CHAMPAIGN,IL 61826, USA. NR 6 TC 1 Z9 1 U1 0 U2 0 PU NATL ASSN CORROSION ENG PI HOUSTON PA 1440 SOUTH CREEK DRIVE, HOUSTON, TX 77084-4906 SN 0094-1492 J9 MATER PERFORMANCE JI Mater. Perform. PD OCT PY 1992 VL 31 IS 10 BP 24 EP 28 PG 5 WC Materials Science, Characterization & Testing SC Materials Science GA JV828 UT WOS:A1992JV82800003 ER PT J AU LETTERIE, GS AF LETTERIE, GS TI SERUM GENTAMICIN CONCENTRATIONS IN POSTPARTUM ENDOMYOMETRITIS SO MILITARY MEDICINE LA English DT Article AB Gentamicin in combination with other antibiotics is frequently used in the treatment of postpartum endomyometritis. The need to monitor and maintain therapeutic concentrations, however, is controversial. To assess the role of monitoring, serum gentamicin concentrations were prospectively studied in an obstetric population treated for postpartum endomyometritis. Clinical course was correlated to serum gentamicin levels obtained using a 1 mg/kg/dose regimen. No patient demonstrated therapeutic concentrations. Sixteen of 18 obstetric patients (88%) exhibited a clinical response despite subtherapeutic serum gentamicin concentrations. The two failures included one case of septicemia and one wound seroma. Serum gentamicin levels of this obstetric population when compared to those from a gynecologic population treated for benign disease demonstrated no statistical difference. These data suggest that clinical response provides an accurate indication of the efficacy of therapy and that gentamicin doses of 1 mg/kg/dose provide sufficient antibiotic coverage in most cases. These results do not support the use of increased gentamicin dosages and the need to attain therapeutic levels in the obstetric patient, as previously suggested. RP LETTERIE, GS (reprint author), TRIPLER ARMY MED CTR,DEPT OBSTET & GYNECOL,HONOLULU,HI 96859, USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD OCT PY 1992 VL 157 IS 10 BP 526 EP 529 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA JT877 UT WOS:A1992JT87700010 PM 1454174 ER PT J AU COMPTON, AB PURVIANCE, M AF COMPTON, AB PURVIANCE, M TI EMOTIONAL DISTRESS IN CHRONIC MEDICAL ILLNESS - TREATMENT WITH TIME-LIMITED GROUP-PSYCHOTHERAPY SO MILITARY MEDICINE LA English DT Article AB Time-limited (12 sessions) group psychotherapy was provided for 14 patients with a variety of serious medical illnesses. All patients were referred for psychiatric assistance and most had minimal or no psychiatric disorder. Patients not terminally ill, in continuous pain, or cognitively impaired, but otherwise unselected, were offered treatment. Emphasis was placed on validation of feelings, interpersonal understanding, and problem solving. Increased sense of well being was noted in all patients by self-report; this was contrasted by findings on the Millon Behavioral Health Inventory indicating generally sustained somatic concern. A moderate reduction in the number of visits to other clinics was noted during the treatment period. Although outcome data are incomplete, this appears to be a useful and cost-effective treatment for mixed groups of emotionally distressed medical patients. RP COMPTON, AB (reprint author), WALTER REED ARMY MED CTR,OUTPATIENT PSYCHIATRY SERV,WASHINGTON,DC 20307, USA. NR 0 TC 5 Z9 5 U1 1 U2 1 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD OCT PY 1992 VL 157 IS 10 BP 533 EP 535 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA JT877 UT WOS:A1992JT87700012 PM 1454176 ER PT J AU JACOB, E ERPELDING, JM MURPHY, KP AF JACOB, E ERPELDING, JM MURPHY, KP TI A RETROSPECTIVE ANALYSIS OF OPEN FRACTURES SUSTAINED BY UNITED-STATES MILITARY PERSONNEL DURING OPERATION JUST CAUSE SO MILITARY MEDICINE LA English DT Article AB A retrospective analysis was conducted of 37 open fracture cases sustained by U.S. military personnel during the recent low-intensity conflict in Panama (Operation Just Cause). The etiology, location, classification, and management of open fractures sustained in combat is presented. A significant difference was noted in the infection rate for type III open fractures that were debrided in Panama (22%) as compared to those that were debrided only after transport to CONUS (66%). This study supports the critical importance of adequate battlefield surgical support in low-intensity conflicts, and reemphasizes the crucial role of early surgical debridement for the prevention of wound infection. RP JACOB, E (reprint author), USA,INST DENT RES,MICROBIOL BRANCH,WASHINGTON,DC 20307, USA. NR 0 TC 39 Z9 40 U1 1 U2 1 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD OCT PY 1992 VL 157 IS 10 BP 552 EP 556 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA JT877 UT WOS:A1992JT87700018 PM 1454182 ER PT J AU KAPLAN, DL FOSSEY, S MELLO, CM ARCIDIACONO, S SENECAL, K MULLER, W STOCKWELL, S BECKWITT, R VINEY, C KERKAM, K AF KAPLAN, DL FOSSEY, S MELLO, CM ARCIDIACONO, S SENECAL, K MULLER, W STOCKWELL, S BECKWITT, R VINEY, C KERKAM, K TI BIOSYNTHESIS AND PROCESSING OF SILK PROTEINS SO MRS BULLETIN LA English DT Article ID BOMBYX-MORI; FIBROIN GENE; SPIDER SILK; SEQUENCES C1 UNIV MASSACHUSETTS,DEPT CHEM,LOWELL,MA. RP KAPLAN, DL (reprint author), USA,NATICK RES DEV & ENGN CTR,DIV BIOTECHNOL,NATICK,MA 01760, USA. RI Senecal, Kris/F-3000-2013 NR 29 TC 26 Z9 27 U1 0 U2 8 PU MATERIALS RESEARCH SOCIETY PI PITTSBURGH PA 9800 MC KNIGHT ROAD SUITE 327, PITTSBURGH, PA 15237 SN 0883-7694 J9 MRS BULL JI MRS Bull. PD OCT PY 1992 VL 17 IS 10 BP 41 EP 47 PG 7 WC Materials Science, Multidisciplinary; Physics, Applied SC Materials Science; Physics GA JT063 UT WOS:A1992JT06300007 ER PT J AU HANDSCHUH, RF KEITH, TG AF HANDSCHUH, RF KEITH, TG TI APPLICATIONS OF AN EXPONENTIAL FINITE-DIFFERENCE TECHNIQUE SO NUMERICAL HEAT TRANSFER PART A-APPLICATIONS LA English DT Article ID HEAT-CONDUCTION; EQUATION AB In this paper an expontial finite-difference scheme, first presented by Bhattacharya for one-dimensional, unsteady heat conduction problems in a plane wall, is used to solve various partial differential equations. Solutions of the unsteady diffusion equation in three dimensions and of the viscous form of Burgers' equation are used to illustrate the method. Predicted results are compared with exact solutions or with results obtained by other numerical methods. C1 UNIV TOLEDO,DEPT MECH ENGN,TOLEDO,OH 43606. RP HANDSCHUH, RF (reprint author), USA,AVIAT RES & TECHNOL ACT,AVSCOM,LEWIS RES CTR,PROPULS DIRECTORATE,CLEVELAND,OH 44135, USA. NR 8 TC 7 Z9 7 U1 0 U2 0 PU HEMISPHERE PUBL CORP PI BRISTOL PA 1900 FROST ROAD, SUITE 101, BRISTOL, PA 19007-1598 SN 1040-7782 J9 NUMER HEAT TR A-APPL JI Numer. Heat Tranf. A-Appl. PD OCT-NOV PY 1992 VL 22 IS 3 BP 363 EP 378 DI 10.1080/10407789208944773 PG 16 WC Thermodynamics; Mechanics SC Thermodynamics; Mechanics GA JU962 UT WOS:A1992JU96200006 ER PT J AU REICHL, RB HEIMKE, J AF REICHL, RB HEIMKE, J TI ANTIBIOTIC CHAIN SO ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS LA English DT Note RP REICHL, RB (reprint author), USA,DENTAC,BOX 269,APO,NEW YORK,NY 09069, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 1079-2104 J9 ORAL SURG ORAL MED O JI Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. PD OCT PY 1992 VL 74 IS 4 BP 531 EP 531 DI 10.1016/0030-4220(92)90307-C PG 1 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA JU445 UT WOS:A1992JU44500020 PM 1408032 ER PT J AU OLSON, EJ HARNER, CD FU, FH SILBEY, MB AF OLSON, EJ HARNER, CD FU, FH SILBEY, MB TI CLINICAL USE OF FRESH, FROZEN SOFT-TISSUE ALLOGRAFTS SO ORTHOPEDICS LA English DT Article AB Fresh frozen allograft tissue provides a good alternative to autogenous tissue for the treatment of patients with symptomatic ligamentous deficiency. While transmission of AIDS and other infectious diseases remains a small possibility, allografts provide the advantages of shorter operative time, small incisions, no damage to a patient's own tissues, and superior usefulness in multiple reconstructions, as well as revision of failed autogenous reconstructions. An independent, critical evaluation of the 4-year results of patients with allograft ACL reconstructions is presented. Issues important in allograft tissue recovery, banking, and intraoperative preparation are reviewed. RP OLSON, EJ (reprint author), UNIFORMED SERV UNIV HLTH SCI,WALTER REED ARMY MED CTR,ORTHOPED SERV,WASHINGTON,DC 20307, USA. NR 0 TC 28 Z9 32 U1 0 U2 1 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 SN 0147-7447 J9 ORTHOPEDICS JI Orthopedics PD OCT PY 1992 VL 15 IS 10 BP 1225 EP 1232 PG 8 WC Orthopedics SC Orthopedics GA JT576 UT WOS:A1992JT57600009 PM 1409131 ER PT J AU ANDRIKO, JA ROBINOWITZ, M MOORE, J VIRMANI, R AF ANDRIKO, JA ROBINOWITZ, M MOORE, J VIRMANI, R TI NECROTIZING ARTERITIS IN UNCORRECTED TETRALOGY OF FALLOT WITH PULMONARY ATRESIA SO PEDIATRIC CARDIOLOGY LA English DT Article DE TETRALOGY OF FALLOT; PULMONARY HYPERTENSION; NECROTIZING ARTERITIS; PULMONARY ATRESIA WITH VENTRICULAR SEPTAL DEFECT ID VENTRICULAR SEPTAL-DEFECT; AORTOPULMONARY COLLATERAL ARTERIES; GROWTH AB A 10-year-old girl with uncorrected tetralogy of Fallot with pulmonary atresia presented with fevers of unknown origin and left lung infiltrates. At autopsy, necrotizing vascular changes resembling those of severe pulmonary hypertension (grade VI in the Heath-Edwards classification) were confined to the left lung. Pulmonary blood flow and pressure were greater in the left lung and were provided by an enlarged collateral artery arising directly from the descending thoracic aorta. To our knowledge, this is the first report of necrotizing arteritis of the pulmonary arteries in uncorrected tetralogy of Fallot with pulmonary atresia. C1 ARMED FORCES INST PATHOL,DEPT CARDIOVASC PATHOL,WASHINGTON,DC 20306. WALTER REED ARMY MED CTR,DEPT PATHOL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT CARDIOL,WASHINGTON,DC 20307. NR 9 TC 3 Z9 3 U1 0 U2 1 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0172-0643 J9 PEDIATR CARDIOL JI Pediatr. Cardiol. PD OCT PY 1992 VL 13 IS 4 BP 233 EP 236 DI 10.1007/BF00838783 PG 4 WC Cardiac & Cardiovascular Systems; Pediatrics SC Cardiovascular System & Cardiology; Pediatrics GA JJ530 UT WOS:A1992JJ53000009 PM 1518744 ER PT J AU OCONNOR, FG SOBEL, JR NIRSCHL, RP AF OCONNOR, FG SOBEL, JR NIRSCHL, RP TI 5-STEP TREATMENT FOR OVERUSE INJURIES SO PHYSICIAN AND SPORTSMEDICINE LA English DT Article AB Overuse injuries can be particularly challenging to manage. An athlete's premature return to athletic activity often results in recurrent and recalcitrant injury. A five-step management plan that includes establishing a pathoanatomic diagnosis, controlling inflammation, promoting healing, increasing fitness, and controlling abusive activity offers athletes optimal opportunity to return successfully to athletic performance. C1 USA,DEWITT COMMUNITY HOSP,FT BELVOIR,VA 22060. NR 0 TC 9 Z9 9 U1 0 U2 0 PU MCGRAW HILL HEALTHCARE PUBLICATIONS PI MINNEAPOLIS PA 4530 WEST 77TH ST, MINNEAPOLIS, MN 55435-5000 SN 0091-3847 J9 PHYSICIAN SPORTSMED JI Physician Sportsmed. PD OCT PY 1992 VL 20 IS 10 BP 128 EP & PG 0 WC Primary Health Care; Orthopedics; Sport Sciences SC General & Internal Medicine; Orthopedics; Sport Sciences GA JQ606 UT WOS:A1992JQ60600012 ER PT J AU ROLADER, GE BATTEH, JH POWELL, JD AF ROLADER, GE BATTEH, JH POWELL, JD TI EFFECT OF CURRENT VARIATION ON THE DYNAMICS OF RAILGUN PLASMA ARMATURES SO PHYSICS OF FLUIDS B-PLASMA PHYSICS LA English DT Article ID ELECTRICAL-CONDUCTIVITY; ARC-DRIVEN; LARGE-BORE; ACCELERATION; SIMULATION; GUNS AB The effect of current variations on the behavior of railgun plasma armatures is investigated with a one-dimensional, time-dependent model. Three typical current profiles are considered: two inductive profiles, one with a time constant of 0.5 msec and the other with a time constant of 2.0 msec, and a capacitive profile. All three calculations are for an armature in a 5 cm square-bore railgun. It is observed that current variations create oscillations in the armature length, projectile acceleration, and projectile jerk. In addition, the current profile significantly affects the axial distribution of the plasma velocity, current density, and total pressure. The significance of these transients on the design of projectiles and the interpretation of diagnostic data is discussed, and suggestions for future calculations are outlined. C1 SCI APPLICAT INT CORP,MARIETTA,GA 30062. USA,BALLIST RES LAB,ABERDEEN PROVING GROUND,MD 21010. RP ROLADER, GE (reprint author), SCI APPLICAT INT CORP,1247-B N EGLIN PKWY,SHALIMAR,FL 32579, USA. NR 34 TC 1 Z9 1 U1 0 U2 1 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0899-8221 J9 PHYS FLUIDS B-PLASMA PD OCT PY 1992 VL 4 IS 10 BP 3418 EP 3426 DI 10.1063/1.860397 PG 9 WC Physics, Fluids & Plasmas SC Physics GA JR694 UT WOS:A1992JR69400042 ER PT J AU IWU, MM JACKSON, JE TALLY, JD KLAYMAN, DL AF IWU, MM JACKSON, JE TALLY, JD KLAYMAN, DL TI EVALUATION OF PLANT-EXTRACTS FOR ANTILEISHMANIAL ACTIVITY USING A MECHANISM-BASED RADIORESPIROMETRIC MICROTECHNIQUE (RAM) SO PLANTA MEDICA LA English DT Article DE LEISHMANIASIS; GONGRONEMA-LATIFOLIA; DORSTENIA-MULTIRADIATA; PICRALIMA-NITIDA; DESMODIUM-GANGETICUM; COLA-ATTIENSIS ID VISCERAL LEISHMANIASIS; ANTIMONY AB Extracts of eleven plants used in Nigerian traditional medicine have been evaluated for possible antileishmanial activity using a radiorespirometric microtest technique based on in vitro inhibition of catabolism of (CO2)-C-14 from a battery of C-14-substrates by promastigotes. Of 13 methanol extracts tested, 5 from Gongronema latifolia, Dorstenia multiradiata, Picralima nitida, Cola attiensis, and Desmodium gangeticum, were active at concentrations of 50 mug/ml or less against a visceral Leishmania isolate. C1 WALTER REED ARMY INST RES,DEPT PARASITOL,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307. RP IWU, MM (reprint author), WALTER REED ARMY INST RES,DEPT MED CHEM,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307, USA. NR 15 TC 25 Z9 25 U1 0 U2 0 PU GEORG THIEME VERLAG PI STUTTGART PA P O BOX 30 11 20, D-70451 STUTTGART, GERMANY SN 0032-0943 J9 PLANTA MED JI Planta Med. PD OCT PY 1992 VL 58 IS 5 BP 436 EP 441 DI 10.1055/s-2006-961508 PG 6 WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary Medicine; Pharmacology & Pharmacy SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary Medicine GA JV096 UT WOS:A1992JV09600011 PM 1470668 ER PT J AU ROGERS, WO MALIK, A MELLOUK, S NAKAMURA, K ROGERS, MD SZARFMAN, A GORDON, DM NUSSLER, AK AIKAWA, M HOFFMAN, SL AF ROGERS, WO MALIK, A MELLOUK, S NAKAMURA, K ROGERS, MD SZARFMAN, A GORDON, DM NUSSLER, AK AIKAWA, M HOFFMAN, SL TI CHARACTERIZATION OF PLASMODIUM-FALCIPARUM SPOROZOITE SURFACE PROTEIN-2 SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE MALARIA; VACCINE; THROMBOSPONDIN RELATED ANONYMOUS PROTEIN; T-CELL WESTERN BLOT; CIRCUMSPOROZOITE PROTEIN ID HUMAN MALARIA PARASITE; T-CELLS RECOGNIZE; CIRCUMSPOROZOITE PROTEIN; MONOCLONAL-ANTIBODIES; ANTIGEN; GENE; SEQUENCE; INVITRO; YOELII; ACID AB Immunization of mice with Plasmodium yoelii sporozoite surface protein 2 (PySSP2) and circumsporozoite protein protects completely against P. yoelii. The amino acid sequence of PySSP2 suggested that the thrombospondin-related anonymous protein (TRAP) [Robson, K. J. H., Hall, J. R. S., Jennings, M. W., Harris, T. J. R., Marsh, K., New-bold, C. I., Tate, V. E. & Weatherall, D. J. (1988) Nature (London) 335, 79-821 is the Plasmodium falciparum homolog of PySSP2. We report data confirming that TRAP is P. falciparum SSP2 (PfSSP2). Murine antibodies against recombinant PfSSP2 identify a 90-kDa protein in extracts of P. falciparum sporozoites, recognize sporozoites and infected hepatocytes by immunofluorescence, localize PfSSP2 to the sporozoite micronemes by immunoelectron microscopy and to the surface membrane by live immunofluorescence, and inhibit sporozoite invasion and development in hepatocytes in vitro. Human volunteers immunized with irradiated sporozoites and protected against malaria develop antibody and proliferative T-cell responses to PfSSP2, suggesting that, like PySSP2, PfSSP2 is a target of protective immunity, and supporting inclusion of PfSSP2 in a multicomponent malaria vaccine. C1 UNIV MARYLAND,SCH MED,CTR VACCINE DEV,BALTIMORE,MD 21201. CASE WESTERN RESERVE UNIV,INST PATHOL,CLEVELAND,OH 44106. US FDA,DIV ANTI INFECT DRUG PROD,ROCKVILLE,MD 20857. HENRY M JACKSON FDN ADV MIL MED,ROCKVILLE,MD 20852. UNIV PITTSBURGH,DEPT SURG,PITTSBURGH,PA 15261. WALTER REED ARMY MED CTR,DEPT IMMUNOL,WASHINGTON,DC 20307. RP ROGERS, WO (reprint author), USN,MED RES INST,MALARIA PROGRAM,BETHESDA,MD 20889, USA. NR 33 TC 175 Z9 177 U1 0 U2 3 PU NATL ACAD PRESS PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD OCT 1 PY 1992 VL 89 IS 19 BP 9176 EP 9180 DI 10.1073/pnas.89.19.9176 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA JQ934 UT WOS:A1992JQ93400066 PM 1409621 ER PT J AU KENNEDY, JM BARNETT, TR FARLEY, GL AF KENNEDY, JM BARNETT, TR FARLEY, GL TI EXPERIMENTAL AND ANALYTICAL EVALUATION OF A BIAXIAL TEST FOR DETERMINING INPLANE SHEAR PROPERTIES OF COMPOSITES SO SAMPE QUARTERLY-SOCIETY FOR THE ADVANCEMENT OF MATERIAL AND PROCESS ENGINEERING LA English DT Article AB The results of an experimental and analytical investigation of a biaxial tension-compression test for determining shear properties of composite materials are presented. A fixture was designed to introduce an equal and opposite pair of forces into a cruciform like specimen. The cruciform specimen was designed using finite element analysis. Carbon-epoxy composite ([90/0]2S and [+/- 45]2S) and aluminum specimens were tested in the fixture. The finite element analysis and strains measured during the tests showed that the stress state in the center of a cruciform specimen with large corner radii was pure shear. Stress gradients near the boundary of the test section were small, and the optimal specimen geometry was independent of laminate orientation. Shear strength was less than anticipated because failure initiated due to instability or due to a complex inplane and interlaminar stress state at the specimen boundaries. The shear stress-strain results from the cruciform test were compared with results from the Iosipescu test and the +/- 45-degrees tensile test. The shear moduli determined with the cruciform specimen compared favorably with the moduli obtained using the other two methods. The lamina shear strength measured using the cruciform specimen was higher than the strength measured using the other methods. The strength of a [+/- 45]2S laminate as determined using the cruciform specimen was lower due to instability related failure than that determined by the Iosipescu shear test. C1 SO RES CORP,BIRMINGHAM,AL. USA,AEROSTRUCT DIRECTORATE,NASA,LANGLEY RES CTR,HAMPTON,VA. RP KENNEDY, JM (reprint author), CLEMSON UNIV,DEPT MECH ENGN,CLEMSON,SC 29631, USA. NR 16 TC 6 Z9 6 U1 1 U2 1 PU SAMPE PUBLISHERS PI COVINA PA 1161 PARKVIEW DRIVE, COVINA, CA 91722 SN 0036-0821 J9 SAMPE QUART PD OCT PY 1992 VL 24 IS 1 BP 28 EP 37 PG 10 WC Engineering, Multidisciplinary; Materials Science, Multidisciplinary SC Engineering; Materials Science GA JT050 UT WOS:A1992JT05000004 ER PT J AU WEISS, RB AF WEISS, RB TI HYPERSENSITIVITY REACTIONS SO SEMINARS IN ONCOLOGY LA English DT Review ID IMMUNE HEMOLYTIC-ANEMIA; NEUTROPHILIC ECCRINE HIDRADENITIS; METHOTREXATE-INDUCED PNEUMONITIS; ACUTE LYMPHOBLASTIC-LEUKEMIA; PHASE-II TRIAL; ALLERGIC CONTACT-DERMATITIS; ACUTE MYELOGENOUS LEUKEMIA; DOSE CYTOSINE-ARABINOSIDE; INTRAVESICAL MITOMYCIN-C; NON-HODGKINS-LYMPHOMA C1 UNESCO,F-75700 PARIS,FRANCE. RP WEISS, RB (reprint author), WALTER REED ARMY MED CTR,MED ONCOL SECT,WASHINGTON,DC 20307, USA. NR 196 TC 94 Z9 95 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0093-7754 J9 SEMIN ONCOL JI Semin. Oncol. PD OCT PY 1992 VL 19 IS 5 BP 458 EP 477 PG 20 WC Oncology SC Oncology GA JT082 UT WOS:A1992JT08200002 PM 1384149 ER PT J AU WANGLER, MF HANSEN, P AF WANGLER, MF HANSEN, P TI VISUALIZING OBJECTS - METHODS FOR EXPLORING HUMAN COMPUTER INTERACTION CONCEPTS SO SIGPLAN NOTICES LA English DT Article; Proceedings Paper CT CONF ON OBJECT-ORIENTED PROGRAMMING SYSTEMS, LANGUAGES, AND APPLICATIONS ( OOPSLA 92 ) CY OCT 18-22, 1992 CL VANCOUVER, CANADA SP ASSOC COMP MACHINERY, SPECIAL INTEREST GRP PROGRAMMING LANGUAGES AB This experience paper discusses the use of index card based analysis tools by small teams of prototypers and system end users as a means for investigating potential Human Computer Interaction (HCI) concepts for future software development purposes. Several refinements to the basic Class-Responsibilities-Collaborators (CRC) card technique referenced in [Beck & Cunningham] have been made including: the use of a scenario narrative to guide the analytical process; the incorporation of user action and object connection cards; the color coding of cards; and the use of story boards and card model diagrams. Emphasis is placed on the identification of object connection types as a means of suggesting temporal, spatial, comparative and organizational HCI metaphors. C1 COMP SCI CORP,DIV APPL TECHNOL,USA,CTR INTELLIGENCE,FT HUACHUCA,AZ. NR 3 TC 0 Z9 0 U1 0 U2 0 PU ASSOC COMPUTING MACHINERY PI NEW YORK PA 1515 BROADWAY, NEW YORK, NY 10036 SN 0362-1340 J9 SIGPLAN NOTICES JI Sigplan Not. PD OCT PY 1992 VL 27 IS 10 BP 146 EP 153 PG 8 WC Computer Science, Software Engineering SC Computer Science GA JU121 UT WOS:A1992JU12100013 ER PT J AU MORRIS, JT KELLY, WJ AF MORRIS, JT KELLY, WJ TI RECURRENCE OF NEISSERIAL MENINGOCOCCEMIA DUE TO DEFICIENCY OF TERMINAL COMPLEMENT COMPONENT SO SOUTHERN MEDICAL JOURNAL LA English DT Note ID INFECTIONS; PREVALENCE; DISEASE; MENINGITIDIS; C8 RP MORRIS, JT (reprint author), BROOKE ARMY MED CTR,INFECT DIS SERV,FT SAM HOUSTON,TX 78234, USA. NR 12 TC 6 Z9 6 U1 0 U2 0 PU SOUTHERN MEDICAL ASSN PI BIRMINGHAM PA 35 LAKESHORE DR PO BOX 190088, BIRMINGHAM, AL 35219 SN 0038-4348 J9 SOUTHERN MED J JI South.Med.J. PD OCT PY 1992 VL 85 IS 10 BP 1030 EP 1031 DI 10.1097/00007611-199210000-00027 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA JU912 UT WOS:A1992JU91200027 PM 1411724 ER PT J AU RICE, BM MURTHY, CS GARRETT, BC AF RICE, BM MURTHY, CS GARRETT, BC TI EFFECTS OF SURFACE-STRUCTURE AND OF EMBEDDED-ATOM PAIR FUNCTIONALS ON ADATOM DIFFUSION ON FCC METALLIC SURFACES SO SURFACE SCIENCE LA English DT Article ID TRANSITION-STATE THEORY; SELF-DIFFUSION; INTERATOMIC INTERACTIONS; EXCHANGE MECHANISM; SINGLE ADATOMS; HYDROGEN; COPPER; MIGRATION; DEFECTS; MOTIONS AB Rates of self-diffusion on the (100) and (110) surfaces of nickel have been calculated using variational transition state theory (VTST) and four different interatomic potential energy functions based on the embedded-atom method (EAM). Static properties of a single nickel atom on the (111) surface, as well as on the (100) and (110) surfaces, are also presented. The embedded-atom pair functionals consist of effective pairwise additive and many-body cohesive interactions parameterized to the bulk and a few defect properties of nickel. VTST calculations of surface diffusion provide Arrhenius parameters and diffusion coefficients for comparison with experiment and among the four EAM potentials employed. An analysis of the estimated diffusion rates based on a hopping mechanism and the four pair functionals reveals that diffusion will occur more readily on the (111) surface and that self-diffusion on the (110) surface exhibits directional anisotropy. The diffusion rate variation from one pair functional to another is interpreted in terms of the effective pair potentials. C1 IBM CORP, E FISHKILL FACIL, CTR SEMICOND RES & DEV, DEPT THEORET MODELING, HOPEWELL JCT, NY 12533 USA. PACIFIC NW LAB, MOLEC SCI RES CTR, RICHLAND, WA 99352 USA. RP RICE, BM (reprint author), USA, BALLIST RES LABS, SLCBR IB I, ABERDEEN PROVING GROUND, MD 21005 USA. RI Garrett, Bruce/F-8516-2011 NR 41 TC 6 Z9 6 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0039-6028 J9 SURF SCI JI Surf. Sci. PD OCT 1 PY 1992 VL 276 IS 1-3 BP 226 EP 240 DI 10.1016/0039-6028(92)90711-E PG 15 WC Chemistry, Physical; Physics, Condensed Matter SC Chemistry; Physics GA JQ016 UT WOS:A1992JQ01600029 ER PT J AU ROBINSON, MC AF ROBINSON, MC TI THIRST FOR GROWTH - WATER AGENCIES AS HIDDEN GOVERNMENT IN CALIFORNIA - GOTTLIEB,R, FITZSIMMONS,M SO TECHNOLOGY AND CULTURE LA English DT Book Review RP ROBINSON, MC (reprint author), USA,CORPS ENGINEERS,MISSISSIPPI RIVER COMMISS,VICKSBURG,MS 39180, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0040-165X J9 TECHNOL CULT JI Technol. Cult. PD OCT PY 1992 VL 33 IS 4 BP 829 EP 830 DI 10.2307/3106612 PG 2 WC History & Philosophy Of Science SC History & Philosophy of Science GA JY490 UT WOS:A1992JY49000028 ER PT J AU HOLMES, K BERGER, T BILLUPS, L SALATA, K LIPPERT, L AF HOLMES, K BERGER, T BILLUPS, L SALATA, K LIPPERT, L TI FLOW CYTOMETRIC ASSAYS FOR ASSESSING POST IRRADIATION RESPONSIVENESS OF LYMPHOCYTES SO TRANSFUSION LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC BLOOD BANKS PI BETHESDA PA 8101 GLENBROOK RD, BETHESDA, MD 20814-2749 SN 0041-1132 J9 TRANSFUSION JI Transfusion PD OCT PY 1992 VL 32 IS 8 SU S BP S7 EP S7 PG 1 WC Hematology SC Hematology GA JW378 UT WOS:A1992JW37800020 ER PT J AU JOYNER, G PRYZBYLIK, J SUPON, P GIANGERUSO, R AF JOYNER, G PRYZBYLIK, J SUPON, P GIANGERUSO, R TI ACUTE HEMOLYTIC TRANSFUSION REACTION DUE TO ANTI-M SO TRANSFUSION LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ASSOC BLOOD BANKS PI BETHESDA PA 8101 GLENBROOK RD, BETHESDA, MD 20814-2749 SN 0041-1132 J9 TRANSFUSION JI Transfusion PD OCT PY 1992 VL 32 IS 8 SU S BP S22 EP S22 PG 1 WC Hematology SC Hematology GA JW378 UT WOS:A1992JW37800078 ER PT J AU SCOVILL, JP BLANEY, MW WEST, DX LIBERTA, AE PANNELL, LK AF SCOVILL, JP BLANEY, MW WEST, DX LIBERTA, AE PANNELL, LK TI TRANSITION-METAL COMPLEXES OF 3-ACETYLISOQUINOLINE THIOSEMICARBAZONES AS POTENTIAL ANTIFUNGAL AGENTS SO TRANSITION METAL CHEMISTRY LA English DT Article ID ION COMPLEXES; COPPER(II) COMPLEXES; FACILE SYNTHESIS; N-OXIDE; 2-ACETYLPYRIDINE; TRANSAMINATION; 4-METHYL-4-PHENYL-3-THIOSEMICARBAZIDE AB Transition metal complexes of two 3-acetylisoquinoline thiosemicarbazones were prepared and characterized by elemental analyses, as well as physical and spectral techniques. The copper(II) complexes appear to have planar stereochemistry while the cobalt(III) and iron(III) complexes are octahedral. They possess less antifungal activity than complexes of the analogous 2-acetylpyridine thiosemicarbazone complexes. C1 US MIL ACAD,DEPT CHEM,W POINT,NY 10996. ILLINOIS STATE UNIV,DEPT CHEM,NORMAL,IL 61761. ILLINOIS STATE UNIV,DEPT BIOL SCI,NORMAL,IL 61761. NIADDKD,BETHESDA,MD 20014. NR 14 TC 2 Z9 2 U1 0 U2 0 PU CHAPMAN HALL LTD PI LONDON PA 2-6 BOUNDARY ROW, LONDON, ENGLAND SE1 8HN SN 0340-4285 J9 TRANSIT METAL CHEM JI Transit. Met. Chem. PD OCT PY 1992 VL 17 IS 5 BP 377 EP 380 DI 10.1007/BF02910711 PG 4 WC Chemistry, Inorganic & Nuclear SC Chemistry GA JQ923 UT WOS:A1992JQ92300003 ER PT J AU SUTHERLAND, DE SMITH, WA AF SUTHERLAND, DE SMITH, WA TI CHEMICAL HEPATITIS ASSOCIATED WITH OCCUPATIONAL EXPOSURE TO HALOTHANE IN A RESEARCH LABORATORY SO VETERINARY AND HUMAN TOXICOLOGY LA English DT Article ID LIVER AB We report a case of clinical hepatitis associated with occupational exposure to halothane in a research laboratory. A biochemist who for 3 y repeatedly used halothane for sedation and euthanization of rats suffered recurrent episodes of epigastric discomfort, culminating in an episode of malaise, anorexia, jaundice and elevated liver associated enzymes that promptly resolved after removal from exposure to halothane. Serologic testing for viral sources and risk factors for non-infectious hepatitis were negative. Halothane-induced hepatitis has been documented as an idiosyncratic reaction among anesthetized patients adn has been reported once in operating room personnel. The mechanism for halothane-induced hepatitis is proposed to be a hypersensitivity reaction to liver neo-antigens produced by the halothane metabolite 2-chloro-1, 1, 1-trifluorethane. C1 EISENHOWER ARMY MED CTR,DEPT FAMILY PRACTICE,FT GORDON,GA 30905. RP SUTHERLAND, DE (reprint author), EISENHOWER ARMY MED CTR,DEPT CLIN INVEST,FT GORDON,GA 30905, USA. NR 9 TC 8 Z9 8 U1 0 U2 0 PU COMPARATIVE TOXICOLOGY LAB PI MANHATTAN PA KANSAS STATE UNIV, MANHATTAN, KS 66506-5606 SN 0145-6296 J9 VET HUM TOXICOL JI Vet. Human Toxicol. PD OCT PY 1992 VL 34 IS 5 BP 423 EP 424 PG 2 WC Toxicology; Veterinary Sciences SC Toxicology; Veterinary Sciences GA JQ028 UT WOS:A1992JQ02800012 PM 1455611 ER PT J AU JAYASURIYA, K AF JAYASURIYA, K TI SUBSTITUENTS EFFECTS IN PHOSPHA ALKYNES - A COMPUTATIONAL INVESTIGATION SO INTERNATIONAL JOURNAL OF QUANTUM CHEMISTRY LA English DT Article ID MICROWAVE-SPECTRUM; COORDINATION; CHEMISTRY AB Ab initio self-consistent field (SCF) molecular orbital calculations were carried out at the MP2/4-31G* level to determine the effect of substituent groups, -F, -NH2, -OH, -CH3, CH2= CH -, and H - C=C- on the C=P triple bond. Although there are considerable differences between the electronegativities of these substituent groups, a characteristic feature found in phospha alkyne derivatives is the weak sensitivity of the C=P bond length to the substituent at the carbon atom. The molecular electrostatic potential analysis clearly reflects the strength of the electronegativity of these substituent groups and their ability to attract the polarizable charge from the C=P triple bond. MEP analyzes further indicates that these derivatives of phospha alkynes are most likely to attract incoming electrophiles to the pi-electron region of the C=triple bond. Transition metals are coordinated "sideways" with phospha alkynes, and in this configuration, the lone-pair electrons of the phosphorus atom are unlikely to interact with the metal. RP JAYASURIYA, K (reprint author), USA,CTR RES DEV & ENGN,CTR GEO,BLDG 3028,PICATINNY ARSENAL,NJ 07806, USA. NR 19 TC 14 Z9 14 U1 0 U2 0 PU JOHN WILEY & SONS INC PI NEW YORK PA 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0020-7608 J9 INT J QUANTUM CHEM JI Int. J. Quantum Chem. PD SEP 30 PY 1992 VL 44 IS 3 BP 327 EP 336 DI 10.1002/qua.560440303 PG 10 WC Chemistry, Physical; Mathematics, Interdisciplinary Applications; Physics, Atomic, Molecular & Chemical SC Chemistry; Mathematics; Physics GA JN511 UT WOS:A1992JN51100002 ER PT J AU SHEN, H RONG, FC LUX, R PAMULAPATI, J TAYSINGLARA, M DUTTA, M POINDEXTER, EH AF SHEN, H RONG, FC LUX, R PAMULAPATI, J TAYSINGLARA, M DUTTA, M POINDEXTER, EH TI FERMI LEVEL PINNING IN LOW-TEMPERATURE MOLECULAR-BEAM EPITAXIAL GAAS SO APPLIED PHYSICS LETTERS LA English DT Article AB The Fermi level position in low temperature (LT) GaAs has been studied by photoreflectance (PR). By etching the LT-GaAs to a different thickness, we find the Fermi level in the as-grown as well as the annealed LT-GaAs is firmly pinned. The pinning position, however, occurs at different energies: 0.47 eV below the conduction band edge for the as-grown samples and 0.65 eV below the conduction band edge for the annealed samples. The pinning in the as-grown LT-GaAs is believed to be the result of a high degree of charge compensation by deep levels, while the pinning in the annealed LT-GaAs is due to the depletion of carriers by the Schottky barrier at the metallic As precipitates. From the measured Fermi level and ionization ratio of As antisites, the (0/+) donor level of the As antisite in LT-GaAs is, for the first time, determined at E(c)-0.57 eV. C1 USA,RES LAB,ELECTR & POWER SOURCES DIRECTORATE,SLCET,ED,FT MONMOUTH,NJ 07703. RUTGERS STATE UNIV,DEPT ELECT & COMP ENGN,PISCATAWAY,NJ 08855. NR 14 TC 39 Z9 39 U1 0 U2 3 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD SEP 28 PY 1992 VL 61 IS 13 BP 1585 EP 1587 DI 10.1063/1.107504 PG 3 WC Physics, Applied SC Physics GA JP604 UT WOS:A1992JP60400036 ER PT J AU WONGSRICHANALAI, C NAMSIRIPONGPUN, V PORNSILAPATIP, J KYLE, DE WILDE, H AF WONGSRICHANALAI, C NAMSIRIPONGPUN, V PORNSILAPATIP, J KYLE, DE WILDE, H TI SENSITIVITY OF QBC MALARIA TEST SO LANCET LA English DT Letter C1 PRA POKKLAO PROV HOSP,DEPT INTERNAL MED,CHANTHABURI,THAILAND. PRA MONGKUTKLAO ARMY HOSP,ROYAL THAI ARMY MED SCH,DEPT BIOCHEM,BANGKOK,THAILAND. THAI RED CROSS SOC,QUEEN SAOVABHA MEM INST,BANGKOK,THAILAND. RP WONGSRICHANALAI, C (reprint author), ARMED FORCES RES INST MED SCI,DEPT IMMUNOL & PARASITOL,BANGKOK 10400,THAILAND. NR 8 TC 6 Z9 6 U1 0 U2 0 PU LANCET LTD PI LONDON PA 42 BEDFORD SQUARE, LONDON, ENGLAND WC1B 3SL SN 0140-6736 J9 LANCET JI Lancet PD SEP 26 PY 1992 VL 340 IS 8822 BP 792 EP 793 DI 10.1016/0140-6736(92)92333-B PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA JP869 UT WOS:A1992JP86900035 PM 1356201 ER PT J AU QIANG, H POLLAK, FH TORRES, CMS LEITCH, W KEAN, AH STROSCIO, MA IAFRATE, GJ KIM, KW AF QIANG, H POLLAK, FH TORRES, CMS LEITCH, W KEAN, AH STROSCIO, MA IAFRATE, GJ KIM, KW TI SIZE DEPENDENCE OF THE THERMAL BROADENING OF THE EXCITON LINEWIDTH IN GAAS/GA0.7AL0.3AS SINGLE QUANTUM-WELLS SO APPLIED PHYSICS LETTERS LA English DT Article ID OPTICAL-PHONON INTERACTION; TEMPERATURE-DEPENDENCE; RAMAN-SCATTERING; CRITICAL-POINTS; GAAS; HETEROSTRUCTURES; SUPERLATTICES; SPECTRA; LO; GE AB We have studied the temperature dependence of the linewidth, GAMMA(T), of the fundamental absorption edge in bulk GaAs and four GaAs/Ga0.7Al0.3As single quantum wells of different well width using photoreflectance. As a result of the size dependence of the exciton-longitudinal optical phonon interaction, the thermal broadening of the linewidth diminishes as the dimensionality and size of the system are reduced. C1 UNIV GLASGOW, DEPT ELECTR & ELECT ENGN, NANOELECTR RES CTR, GLASGOW G12 8QQ, SCOTLAND. USA, RES OFF, RES TRIANGLE PK, NC 27709 USA. N CAROLINA STATE UNIV, DEPT ELECT ENGN, RALEIGH, NC 27696 USA. CUNY GRAD SCH & UNIV CTR, NEW YORK, NY 10036 USA. RP QIANG, H (reprint author), CUNY BROOKLYN COLL, DEPT PHYS, BROOKLYN, NY 11210 USA. RI Sotomayor Torres, Clivia/E-8418-2010 OI Sotomayor Torres, Clivia/0000-0001-9986-2716 NR 31 TC 56 Z9 56 U1 0 U2 1 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD SEP 21 PY 1992 VL 61 IS 12 BP 1411 EP 1413 DI 10.1063/1.107554 PG 3 WC Physics, Applied SC Physics GA JN991 UT WOS:A1992JN99100015 ER PT J AU ZHOU, WM SHEN, H HARVEY, JF LUX, RA DUTTA, M LU, F PERRY, CH TSU, R KALKHORAN, NM NAMAVAR, F AF ZHOU, WM SHEN, H HARVEY, JF LUX, RA DUTTA, M LU, F PERRY, CH TSU, R KALKHORAN, NM NAMAVAR, F TI HIGH-PRESSURE OPTICAL INVESTIGATION OF POROUS SILICON SO APPLIED PHYSICS LETTERS LA English DT Article AB We have performed the first photoluminescence (PL) measurements under hydrostatic pressure up to 37 kbar at room temperature on several porous silicon (Si) samples fabricated under different etching conditions. A blue shift of the PL peak energy was observed in all samples from 0 to approximately 20 kbar. Above approximately 20 kbar, the PL peak energy appears to be constant or even to exhibit a small red shift with pressure in some samples. This pressure dependence of the PL peak energy of porous Si is different from the pressure induced red shift in the PL from the indirect band gap of the bulk Si crystal, or the red shift in the PL from amorphous Si. The intensity of the PL peaks showed a decrease with increasing pressure. We have also observed a red shift with time when a blue laser continuously illuminated the sample. These results on the pressure dependence of porous Si provide critical information for modeling and determining the electronic structure of porous silicon. C1 NORTHEASTERN UNIV,BOSTON,MA 02115. UNIV N CAROLINA,CHARLOTTE,NC 28223. SPIRE CORP,BEDFORD,MA 01730. GEOCENTERS INC,LAKE HOPATCONG,NJ 07849. RP ZHOU, WM (reprint author), USA,ELECTR TECHNOL & DEVICE LAB,FT MONMOUTH,NJ 07703, USA. NR 23 TC 32 Z9 32 U1 0 U2 2 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD SEP 21 PY 1992 VL 61 IS 12 BP 1435 EP 1437 DI 10.1063/1.108466 PG 3 WC Physics, Applied SC Physics GA JN991 UT WOS:A1992JN99100023 ER PT J AU TOFSTED, DH AF TOFSTED, DH TI OUTER-SCALE EFFECTS ON BEAM-WANDER AND ANGLE-OF-ARRIVAL VARIANCES SO APPLIED OPTICS LA English DT Article DE ATMOSPHERIC OPTICS; BEAMS; PROPAGATION AB Single-integral equations are developed for the angle-of-arrival and beam-wander variances of propagated gaussian and uniform-intensity beams through refractive turbulence with a finite outer scale. The equations developed for Gaussian beams include initial wave-front curvature, diffraction, and turbulent spreading effects. Form-fitting expressions are used in both cases to reduce second- and third-order integral equations into equivalent single-integral forms. Numerical calculations with these new approximations give results within a few percent of the results obtained by using the more rigorous multiple integral expressions. Spectral analysis indicates that the refractive-index turbule size with the greatest influence on beam wander and angle of arrival is proportional to the outer-scale size. RP TOFSTED, DH (reprint author), USA,ATMOSPHER SCI LAB,SLCAS AM T,WHITE SANDS MISSILE RANGE,NM 88002, USA. NR 19 TC 24 Z9 24 U1 0 U2 0 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0003-6935 J9 APPL OPTICS JI Appl. Optics PD SEP 20 PY 1992 VL 31 IS 27 BP 5865 EP 5870 PG 6 WC Optics SC Optics GA JN788 UT WOS:A1992JN78800019 PM 20733779 ER PT J AU KRISHNAMURTI, C BOLAN, CD REID, TJ ALVING, BM AF KRISHNAMURTI, C BOLAN, CD REID, TJ ALVING, BM TI SAFE AND SUCCESSFUL CLINICAL USE OF THE DEFIBRINOGENATING AGENT ANCROD - RESPONSE SO BLOOD LA English DT Letter ID ENDOTOXIN RP KRISHNAMURTI, C (reprint author), WALTER REED ARMY MED CTR,DEPT HEMATOL,WASHINGTON,DC 20307, USA. NR 7 TC 1 Z9 1 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0006-4971 J9 BLOOD JI Blood PD SEP 15 PY 1992 VL 80 IS 6 BP 1627 EP 1628 PG 2 WC Hematology SC Hematology GA JN507 UT WOS:A1992JN50700041 ER PT J AU SHAFFER, DW BURRIS, HA OROURKE, TJ AF SHAFFER, DW BURRIS, HA OROURKE, TJ TI TESTICULAR RELAPSE IN ADULT ACUTE MYELOGENOUS LEUKEMIA SO CANCER LA English DT Article DE ACUTE MYELOGENOUS LEUKEMIA; TESTES; LEUKEMIA; ACUTE MONOCYTIC LEUKEMIA; RELAPSE; OPTIC NERVE ID ACUTE LYMPHOCYTIC-LEUKEMIA; ACUTE MONOBLASTIC LEUKEMIA; ACUTE LYMPHOBLASTIC-LEUKEMIA; GRANULOCYTIC SARCOMA; CHILDHOOD LEUKEMIA; INVOLVEMENT; CHILDREN; LYMPHOMA; CHEMOTHERAPY; DIAGNOSIS AB Testicular relapse (TR) in adult acute myelogenous leukemia (AML) is uncommon, occurring in only 1-2% of patients with bone marrow relapse. TR in the absence of systemic relapse has been reported previously in 2 adults and 12 children, of which 67% were monocytic variants of AML. This article presents the case of a 29-year-old man with AML that relapsed in his testicle without evidence of bone marrow relapse. This patient and the two previously mentioned adults experienced bone marrow relapse within 2 months and died within 7 months of their TR. TR in adult myelogenous leukemia should be considered a harbinger of systemic relapse and suggests a need for aggressive local and systemic therapy. C1 BROOKE ARMY MED CTR,DEPT MED,HEMATOL ONCOL SERV,FT SAM HOUSTON,TX 78234. NR 37 TC 7 Z9 7 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0008-543X J9 CANCER JI Cancer PD SEP 15 PY 1992 VL 70 IS 6 BP 1541 EP 1544 DI 10.1002/1097-0142(19920915)70:6<1541::AID-CNCR2820700616>3.0.CO;2-6 PG 4 WC Oncology SC Oncology GA JN875 UT WOS:A1992JN87500015 PM 1516005 ER PT J AU KIM, KW BHATT, AR STROSCIO, MA TURLEY, PJ TEITSWORTH, SW AF KIM, KW BHATT, AR STROSCIO, MA TURLEY, PJ TEITSWORTH, SW TI EFFECTS OF INTERFACE PHONON-SCATTERING IN MULTIHETEROINTERFACE STRUCTURES SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID QUANTUM-WELL; ELECTRONIC POLARIZABILITY; DOUBLE HETEROSTRUCTURES; FROHLICH INTERACTION; EMISSION; SYSTEMS; VALLEY; MODES AB In this paper, the commonly used but idealistic formulation of quantized optical-phonon modes for a heterostructure system with only two heterojunctions (i.e., single quantum-well structures) is extended to the more realistic case of multiheterointerface structures. By applying the macroscopic dielectric continuum approach, dispersion relations and interaction Hamiltonians for interface-phonon modes are derived for a double-barrier structure and scattering rates based on these results are used to determine the range of practical validity of the idealistic model using interaction Hamiltonians appropriate for single quantum wells with infinite barrier widths. It is found that when the dimensions of the structures are larger than approximately 30 angstrom, this simplified description can be applied to multiheterointerface structures in general with reasonable accuracy. C1 USA,RES OFF,RES TRIANGLE PK,NC 27709. DUKE UNIV,DEPT PHYS,DURHAM,NC 27706. RP KIM, KW (reprint author), N CAROLINA STATE UNIV,DEPT ELECT & COMP ENGN,RALEIGH,NC 27695, USA. NR 23 TC 19 Z9 20 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD SEP 15 PY 1992 VL 72 IS 6 BP 2282 EP 2287 DI 10.1063/1.351569 PG 6 WC Physics, Applied SC Physics GA JN512 UT WOS:A1992JN51200029 ER PT J AU CARR, FE KASEEM, LL WONG, NCW AF CARR, FE KASEEM, LL WONG, NCW TI THYROID-HORMONE INHIBITS THYROTROPIN GENE-EXPRESSION VIA A POSITION-INDEPENDENT NEGATIVE L-TRIIODOTHYRONINE-RESPONSIVE ELEMENT SO JOURNAL OF BIOLOGICAL CHEMISTRY LA English DT Article ID BETA-SUBUNIT GENE; RECEPTOR INTERACTION; PROMOTER ACTIVITY; NUCLEAR-PROTEIN; BINDING-SITE; TRANSCRIPTION; CELLS; 3,5,3'-TRIIODOTHYRONINE; IDENTIFICATION; ACTIVATION AB We have previously identified a 57-bp DNA fragment encompassing exon 1 of the beta-subunit gene of rat thyrotropin (rTSH-beta) that mediates the negative response to L-triiodothyronine (T3). To determine the specific motif that confers this negative regulation, we tested the T3 sensitivity of various segments of this 57-bp gene fragment in transiently transfected pituitary tumor cells, GH3. The suppressive effects were mediated by a 17-bp motif (+11/+27, CGCCAGTGCAAAGTAAG) located at the 3' end of exon 1. The inhibitory effects mediated by the sequence were evident when a single copy of the motif was inserted 125 bp upstream or 11 bp downstream of the transcriptional start site. These findings indicate that the suppressive effect of T3 is an intrinsic property of the T3-responsive element and not dependent on position relative to the promoter. The T3 receptor (T3R) extracted from GH3 cells or expressed in vitro bound specifically to this sequence. Specific mutations introduced into this region result in a selective loss of nuclear protein binding and a corresponding loss of T3 sensitivity. Additional studies showed that the 17-bp sequence was not responsive to T3 in COS cells which lack endogenous T3R. Cotransfection of a T3R restored the T3 responsiveness of the TSH-beta motif. In summary, we have identified an element in the rTSH-beta gene that mediates negative regulation by T3 and binds to the T3R. C1 UNIV CALGARY,DEPT MED,CALGARY T2N 4N1,ALBERTA,CANADA. UNIV CALGARY,DEPT MED BIOCHEM,CALGARY T2N 4N1,ALBERTA,CANADA. RP CARR, FE (reprint author), WALTER REED ARMY MED CTR,DEPT CLIN INVEST,KYLE METAB UNIT,RES LABS,WASHINGTON,DC 20307, USA. NR 32 TC 52 Z9 52 U1 0 U2 0 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0021-9258 J9 J BIOL CHEM JI J. Biol. Chem. PD SEP 15 PY 1992 VL 267 IS 26 BP 18689 EP 18694 PG 6 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA JN502 UT WOS:A1992JN50200068 PM 1527000 ER PT J AU GREEN, SJ CHEN, TY CRAWFORD, RM NACY, CA MORRISON, DC MELTZER, MS AF GREEN, SJ CHEN, TY CRAWFORD, RM NACY, CA MORRISON, DC MELTZER, MS TI CYTOTOXIC ACTIVITY AND PRODUCTION OF TOXIC NITROGEN-OXIDES BY MACROPHAGES TREATED WITH IFN-GAMMA AND MONOCLONAL-ANTIBODIES AGAINST THE 73-KDA LIPOPOLYSACCHARIDE RECEPTOR SO JOURNAL OF IMMUNOLOGY LA English DT Article ID TUMOR-NECROSIS-FACTOR; LIMULUS AMEBOCYTE LYSATE; INTERFERON-GAMMA; L-ARGININE; BINDING-PROTEINS; NITRIC-OXIDE; FACTOR-ALPHA; LIPID-A; BACTERIAL LIPOPOLYSACCHARIDES; PERITONEAL-MACROPHAGES AB The hamster IgM mAb 5D3 is specific for an 73-kDa LPS receptor on murine leukocytes. This mAb inhibits binding of radiolabeled LPS to splenocytes and acts as an agonist for induction of LPS-mediated changes in macrophage function. Resident peritoneal macrophages treated with IFN-gamma and mAb 5D3 developed potent cytotoxic activity against tumor cells. Cells treated with IFN-gamma or mAb 5D3 alone were inactive. Macrophage cytotoxic activity induced by IFN-gamma and mAb 5D3 was inhibited by N(G)MMLA and coincident with high levels of NO2- released into culture fluids. These data show that mAb 5D3 serves as an effective trigger signal for induction of cytotoxide activity with IFN-gamma-primed macrophages. Indeed, mAb 5D3 exactly mimicked the effects of LPS in these same systems. Unlike LPS, effects of mAb 5D3 on induction of macrophage cytotoxic activity and production of nitrogen oxides was abrogated after boiling, and not affected by addition of polymyxin B. The effects of LPS and mAb 5D3 as a trigger signal for IFN-gamma-primed macrophages were associated with production of TNF activity in culture fluids and inhibited by mAb against rTNF-alpha. Expression of class II MHC on macrophages induced by IFN-gamma treatment was suppressed by both LPS and mAb 5D3. These suppressive effects of LPS and mAb 5D3 were not affected by N(G)MMLA or mAb against rTNF-alpha. Finally, macrophages treated with LPS or mAb 5D3 before exposure to IFN-gamma and LPS or mAb 5D3 did not develop cytotoxic activity or high levels of NO2- in the culture fluids. These same cells developed both effector activities after addition of rTNF-alpha. These results in toto identify the 73-kDa protein as a receptor that mediates LPS-induced changes in macrophage effector function. The mAb 5D3 serves as a specific and defined reagent agonist for analysis of LPS receptor-linked change. C1 WALTER REED ARMY MED CTR,DEPT CELLULAR IMMUNOL,WASHINGTON,DC 20307. UNIV KANSAS,MED CTR,DEPT MICROBIOL MOLEC GENET & IMMUNOL,KANSAS CITY,KS 66103. NR 48 TC 38 Z9 38 U1 0 U2 0 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD SEP 15 PY 1992 VL 149 IS 6 BP 2069 EP 2075 PG 7 WC Immunology SC Immunology GA JN121 UT WOS:A1992JN12100033 PM 1381395 ER PT J AU KROLL, DM GOMPPER, G AF KROLL, DM GOMPPER, G TI SCALING BEHAVIOR OF RANDOMLY TRIANGULATED SELF-AVOIDING SURFACES SO PHYSICAL REVIEW A LA English DT Article ID MONTE-CARLO; CRUMPLING TRANSITION; TETHERED MEMBRANES; UNIVERSAL FEATURES; BRANCHED POLYMERS; DYNAMICS; CLUSTERS; DIMENSION; STATICS; SHAPES AB The conformation and scaling properties of two-dimensional randomly triangulated self-avoiding surfaces embedded in three-dimensional space are studied using Monte Carlo methods. Results for the fractal dimension d(f) and the spectral dimension d(s), as well as the ratios of the eigenvalues of the moment of inertia tensor (which characterize the mean shapes of the surfaces), are presented. It is shown that these surfaces belong to the self-avoiding branched polymer universality class. C1 UNIV MUNICH,SEKT PHYS,W-8000 MUNICH 2,GERMANY. RP KROLL, DM (reprint author), UNIV MINNESOTA,ARMY HIGH PERFORMANCE COMP RES CTR,1100 WASHINGTON AVE S,MINNEAPOLIS,MN 55415, USA. RI Gompper, Gerhard/I-4886-2012 OI Gompper, Gerhard/0000-0002-8904-0986 NR 36 TC 23 Z9 23 U1 2 U2 3 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1050-2947 J9 PHYS REV A JI Phys. Rev. A PD SEP 15 PY 1992 VL 46 IS 6 BP 3119 EP 3122 DI 10.1103/PhysRevA.46.3119 PG 4 WC Optics; Physics, Atomic, Molecular & Chemical SC Optics; Physics GA JQ375 UT WOS:A1992JQ37500023 ER PT J AU MCANULTY, P MEISEL, LV COTE, PJ AF MCANULTY, P MEISEL, LV COTE, PJ TI HYPERBOLIC DISTRIBUTIONS AND FRACTAL CHARACTER OF FRACTURE SURFACES SO PHYSICAL REVIEW A LA English DT Note ID DIMENSION; TOUGHNESS AB The fractal character of fracture surfaces of thick-walled pressure vessels produced in the final fast fracture that terminates low-cycle-fatigue tests is compared with that of fracture surfaces produced in Charpy impact tests in samples of the same high-strength and -toughness steel (ASTM A723) alloy. Slit island analysis yielded fractal dimensions near 1.25 for the Charpy specimens, which is typical of highstrength steel alloys previously studied; however, extremely high fractal dimensions near 1.40 were determined for the low-cycle-fatigue specimens. The distributions of island and lake areas and of island and lake perimeters on random sections exhibit hyperbolic distributions analogous to those found for geographic islands and lakes. C1 CLOSE COMBAT ARMAMENT CTR,CTR RES DEV & ENGN,BENET LABS,WATERVLIET,NY 12189. RP MCANULTY, P (reprint author), US MIL ACAD,DEPT CIVIL & MECH ENGN,W POINT,NY 10996, USA. NR 11 TC 23 Z9 23 U1 0 U2 0 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1050-2947 J9 PHYS REV A JI Phys. Rev. A PD SEP 15 PY 1992 VL 46 IS 6 BP 3523 EP 3526 DI 10.1103/PhysRevA.46.3523 PG 4 WC Optics; Physics, Atomic, Molecular & Chemical SC Optics; Physics GA JQ375 UT WOS:A1992JQ37500063 ER PT J AU FU, LP SCHMIEDEL, T PETROU, A DUTTA, M NEWMAN, PG STROSCIO, MA AF FU, LP SCHMIEDEL, T PETROU, A DUTTA, M NEWMAN, PG STROSCIO, MA TI RAMAN-STUDY OF INTERFACE PHONONS IN GAAS/ALAS QUANTUM-WELLS - RESONANCE WITH THE E2-H2 EXCITON SO PHYSICAL REVIEW B LA English DT Note ID GAAS-ALAS SUPERLATTICES; GAAS-ALXGA1-XAS SUPERLATTICES; VIBRATIONAL-MODES; CONFINED LO; SCATTERING; HETEROSTRUCTURES AB We have performed light-scattering experiments from two GaAs/AlAs quantum-well structures. In one sample, the second conduction confinement subband e2 is near degenerate with the AlAs X-band minimum. Raman spectra excited resonantly with the e2-h2 transition contain phonon modes associated with both the GaAs and the AlAs layers. The resonantly excited AlAs phonon modes have an average frequency of 385 cm-1 whereas in nonresonant Raman experiments the observed shift is 405 cm-1. This indicates that the AlAs phonon spectra observed under resonant conditions are dominated by interface modes. Resonant Raman spectra from the second sample, in which the e2 State is below the X-band minimum, contain only phonon modes associated with the GaAs layers. C1 SUNY BUFFALO,CTR ELECTR & ELECTROOPT MAT,BUFFALO,NY 14260. USA,ELECTR TECHNOL & DEVICES LAB,FT MONMOUTH,NJ 07703. USA,RES OFF,RES TRIANGLE PK,NC 27709. RP FU, LP (reprint author), SUNY BUFFALO,DEPT PHYS & ASTRON,BUFFALO,NY 14260, USA. NR 25 TC 10 Z9 11 U1 0 U2 1 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0163-1829 J9 PHYS REV B JI Phys. Rev. B PD SEP 15 PY 1992 VL 46 IS 11 BP 7196 EP 7199 DI 10.1103/PhysRevB.46.7196 PG 4 WC Physics, Condensed Matter SC Physics GA JN826 UT WOS:A1992JN82600065 ER PT J AU MAKOUS, JL LAREAU, RT HUES, SM AF MAKOUS, JL LAREAU, RT HUES, SM TI OXYGEN INCORPORATION IN MO/NI MULTILAYERS SO THIN SOLID FILMS LA English DT Article ID SUPER-LATTICES; SUPERLATTICES; ANOMALIES; WAVES AB We describe the effects of oxygen incorporation on the structural and elastic properties of Mo/Ni multilayers. Auger depth profiling analyses of the multilayers show that the oxygen level in the nickel layers saturates at 7 at.% while that in the molybdenum layers steadily increases as the average oxygen incorporation in the multilayers is increased to 20 at.%. X-ray diffraction measurements indicate that a structural transition from coherent superlattices to incoherent multilayers occurs at an average bilayer oxygen concentration of about 10-12 at.%. At oxygen concentrations above this level the structural analyses of the individual molybdenum and nickel layers indicate a continuous breakdown in the ordering of the molybdenum layers concurrent with an improvement in the structural order in the nickel. Surface acoustic wave velocity measurements demonstrate an elastic hardening with increasing oxygen incorporation that is consistent with the observed relaxation in the nickel layers and with previous work on the elastic properties of Mo/Ni multilayers. C1 USA,ETDL,SLCET,EJ,FT MONMOUTH,NJ 07703. RP MAKOUS, JL (reprint author), USN,RES LAB,DIV CHEM,WASHINGTON,DC 20375, USA. NR 27 TC 1 Z9 1 U1 0 U2 0 PU ELSEVIER SCIENCE SA LAUSANNE PI LAUSANNE 1 PA PO BOX 564, 1001 LAUSANNE 1, SWITZERLAND SN 0040-6090 J9 THIN SOLID FILMS JI Thin Solid Films PD SEP 15 PY 1992 VL 216 IS 2 BP 259 EP 267 DI 10.1016/0040-6090(92)90847-5 PG 9 WC Materials Science, Multidisciplinary; Materials Science, Coatings & Films; Physics, Applied; Physics, Condensed Matter SC Materials Science; Physics GA JP379 UT WOS:A1992JP37900011 ER PT J AU HUH, M DAVIS, W AF HUH, M DAVIS, W TI INTRAVENOUS IMMUNE GLOBULIN VERSUS PLASMA-EXCHANGE IN GUILLAIN-BARRE-SYNDROME SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Letter RP HUH, M (reprint author), WALTER REED ARMY MED CTR,WASHINGTON,DC 20307, USA. NR 4 TC 0 Z9 0 U1 0 U2 0 PU MASS MEDICAL SOC PI BOSTON PA 10 SHATTUCK, BOSTON, MA 02115 SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD SEP 10 PY 1992 VL 327 IS 11 BP 817 EP 817 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA JL661 UT WOS:A1992JL66100030 PM 1501670 ER PT J AU BHATTACHARJEE, AK KWONCHUNG, KJ GLAUDEMANS, CPJ AF BHATTACHARJEE, AK KWONCHUNG, KJ GLAUDEMANS, CPJ TI THE MAJOR CAPSULAR POLYSACCHARIDE OF CRYPTOCOCCUS-NEOFORMANS SEROTYPE-B SO CARBOHYDRATE RESEARCH LA English DT Note C1 NIH,BETHESDA,MD 20892. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 2 TC 7 Z9 7 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0008-6215 J9 CARBOHYD RES JI Carbohydr. Res. PD SEP 2 PY 1992 VL 233 BP 271 EP 272 DI 10.1016/S0008-6215(00)90942-X PG 2 WC Biochemistry & Molecular Biology; Chemistry, Applied; Chemistry, Organic SC Biochemistry & Molecular Biology; Chemistry GA JP243 UT WOS:A1992JP24300027 PM 1446311 ER PT J AU LEWIS, MG ZACK, PM ELKINS, WR JAHRLING, PB AF LEWIS, MG ZACK, PM ELKINS, WR JAHRLING, PB TI INFECTION OF RHESUS AND CYNOMOLGUS MACAQUES WITH A RAPIDLY FATAL SIV (SIVSMM/PBJ) ISOLATE FROM SOOTY MANGABEYS SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Article ID SIMIAN IMMUNODEFICIENCY VIRUS; AFRICAN-GREEN MONKEYS; NECROSIS-FACTOR-ALPHA; T-CELL ACTIVATION; INTERLEUKIN-6; IL-6; PROLIFERATION; RETROVIRUS; SEQUENCE; AIDS AB A variant of simian immunodeficiency virus (SIV(smm/PBj)), isolated from a chronically infected pig-tailed macaque has been shown in previous studies to produce acutely fatal disease uniformly in pig-tailed macaques and in some rhesus macaques. The present study extends investigation of SIV(smm/PBj) pathogenesis in rhesus and cynomolgus monkeys. Cynomolgus and rhesus macaques were found to be uniformly susceptible to infection, but as previously reported, the rhesus were found to not be uniform in their response during the acute disease. Homogenized tissues from a rhesus that died acutely from SIV(smm/PBj) were passaged to 6 rhesus monkeys in an attempt to increase lethality. Five of 6 rhesus monkeys receiving intravenous inoculation of either spleen (10(3) TCID50) or lymph node (10(5) TCID50) homogenate developed acute disease; 4 died (days 8-10), 1 recovered, and one rhesus remained asymptomatic. Three of 3 cynomolgus macaques and 4 of 4 pig-tailed macaques receiving the same inoculum died acutely within 9 days. Clinical disease in macaques that died was characterized by diffuse lymphadenopathy within 5 days of inoculation and severe diarrhea beginning 1 to 3 days before death. Anorexia, lymphopenia (<1000 cells/mm3), and mild hypoalbuminemia preceded onset of diarrhea by 24 h. Viral p27 was detected in circulation by day 6 postinfection, with all animals dying acutely having detectable serum p27 and no detectable humoral response. Acute lethality was attributed to severe metabolic acidosis (pH <7.20) which was observed 24-48 h prior to death in the pig-tailed and cynomolgus macaques. Immunohistochemistry revealed numerous SIV antigen-positive lymphocytes and macrophages in the lymph nodes, spleen, gut-associated lymphoid tissues and gastrointestinal lamina propria. Histopathologic lesions included marked to severe hyperplasia of the T-cell-dependent areas in lymphoid tissues and diffuse nonulcerative lymphohistiocytic gastroenteritis. Surviving rhesus developed strong humoral immune responses to the major SIV proteins. C1 SO RES INST,FREDERICK RES CTR,FREDERICK,MD 21701. USA,MED RES INST INFECT DIS,DIV PATHOL,FREDERICK,MD 21702. USA,MED RES INST INFECT DIS,DIV DIS ASSESSMENT,FREDERICK,MD 21702. FU PHS HHS [IU01A125619-01] NR 41 TC 48 Z9 48 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD SEP PY 1992 VL 8 IS 9 BP 1631 EP 1639 DI 10.1089/aid.1992.8.1631 PG 9 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA JW296 UT WOS:A1992JW29600014 PM 1457209 ER PT J AU ABELS, R AF ABELS, R TI UNIFICATION AND CONQUEST - A POLITICAL AND SOCIAL-HISTORY OF ENGLAND IN THE 10TH-CENTURY AND 11TH-CENTURY - STAFFORD,P SO ALBION LA English DT Book Review RP ABELS, R (reprint author), US MIL ACAD,W POINT,NY 10996, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU APPALACHIAN STATE UNIV PI BOONE PA ALBION/HISTORY DEPT 210 WHITENER HALL, BOONE, NC 28608 SN 0095-1390 J9 ALBION JI Albion PD FAL PY 1992 VL 24 IS 3 BP 447 EP 449 DI 10.2307/4050949 PG 3 WC History SC History GA KG858 UT WOS:A1992KG85800007 ER PT J AU BENT, RC WISWELL, TE CHANG, A AF BENT, RC WISWELL, TE CHANG, A TI REMOVING MECONIUM FROM INFANT TRACHEAS - WHAT WORKS BEST SO AMERICAN JOURNAL OF DISEASES OF CHILDREN LA English DT Article ID ASPIRATION AB Objective.-At least nine mechanical devices are available for suctioning the tracheae of meconium-stained newborns. To our knowledge, the efficacy of these devices, as well as various suction pressures and patterns, has not been previously compared. We performed this investigation to assess these variables. Design.-Fourteen suction techniques (combinations of device, suction pressure, and suction intermittency) were evaluated sequentially in the trachea of each of 14 in vitro newborn piglets (1 to 4 days old); the order was randomized using a Latin square design. We chose three devices to compare: a meconium aspirator (Neotech Products Inc, Chatsworth, Calif), a hand pump (Res-Q-Vac, Repromed Systems Inc, New York, NY), and a 10F suction catheter (Superior Healthcare Group Inc, Cumberland, RI). Both the meconium aspirator and the hand pump were used with a 3.0-mm endotracheal tube. Intervention.-We instilled 0.8 mL of a homogeneous mixture of human meconium and saline (44 g of meconium per 100 mL of saline) in the trachea before applying each suction technique. The meconium aspirator and the suction catheter were each evaluated at three different vacuum pressures, -40, -80, and -150 mm Hg using both continuous and interrupted suction. The hand pump was evaluated with one and two activations (one activation generates -100 cm H2O, according to the manufacturer). Measurements and Results.-The percentage of instilled meconium recovered was consistently greatest (P<.001) with the meconium aspirator (mean, 88.9% at -150 mm Hg, 84.9% at -80 mm Hg, and 73.5% at -40 mm Hg), intermediate with the catheter (mean, 81.0% at -150 mm Hg, 73.2% at -80 mm Hg, and 67.5% at -40 mm Hg), and least for the hand pump (mean, 67.9% with one activation and 72.6% with two activations). Recovery was better with continuous suction (P=.02) and increasing pressure (P<.001). Conclusions.-Among the techniques compared, the meconium aspirator at -150 mm Hg, using continuous suction, performed best in this model. It is unknown, however, to what extent the tracheal mucosa may be affected by this degree of negative pressure. C1 WALTER REED ARMY MED CTR,DEPT PEDIAT,6825 16TH ST NW,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. NR 19 TC 15 Z9 15 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0002-922X J9 AM J DIS CHILD JI Am. J. Dis. Child. PD SEP PY 1992 VL 146 IS 9 BP 1085 EP 1089 PG 5 WC Pediatrics SC Pediatrics GA JL620 UT WOS:A1992JL62000027 PM 1514556 ER PT J AU SHAY, SS ABREU, SH TSUCHIDA, A AF SHAY, SS ABREU, SH TSUCHIDA, A TI SCINTIGRAPHY IN GASTROESOPHAGEAL REFLUX DISEASE - A COMPARISON TO ENDOSCOPY, LESP, AND 24-H PH SCORE, AS WELL AS TO SIMULTANEOUS PH MONITORING SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Article ID ESOPHAGUS AB We compared scintigraphy to other reflux tests in 45 symptomatic patients. Sensitivity of 24-h pH score was 82%, endoscopy 64%, and LESp 33%. Scintigraphy was insensitive (36%), although 50% of patients with esophagitis had a positive test. Specificity and positive predictive value were good (all greater-than-or-equal-to 88%) in discerning patients with an abnormal 24-h pH score and esophagitis. We suggest scintigraphy as the first diagnostic test to confirm frequent reflux events (REs) and normal clearance in the subgroup of patients with severe endoscopic esophagitis, and manometry and 24-h pH monitoring when scintigraphy is negative. We also compared scintigraphy to simultaneously performed pH monitoring in detecting individual postprandial REs and their clearance. The two methods agreed in only 25% of total reflux events. Scintigraphy was superior at detection of reflux of buffered gastric contents and detection of additional REs during acid clearing intervals, whereas only the pH probe detected REs after gastric emptying. We conclude that scintigraphy has a limited role as a diagnostic test in gastroesophageal reflux disease, and much potential as a research tool, especially in combination with the pH probe. C1 WALTER REED ARMY MED CTR, DEPT MED, GASTROENTEROL SERV, WASHINGTON, DC 20307 USA. WALTER REED ARMY MED CTR, DEPT RADIOL, NUCL MED SERV, WASHINGTON, DC 20307 USA. NR 18 TC 35 Z9 35 U1 0 U2 4 PU NATURE PUBLISHING GROUP PI NEW YORK PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA SN 0002-9270 EI 1572-0241 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD SEP PY 1992 VL 87 IS 9 BP 1094 EP 1101 PG 8 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA JM984 UT WOS:A1992JM98400005 PM 1519565 ER PT J AU MARK, AS BLAKE, P ATLAS, SW ROSS, M BROWN, D KOLSKY, M AF MARK, AS BLAKE, P ATLAS, SW ROSS, M BROWN, D KOLSKY, M TI GD-DTPA ENHANCEMENT OF THE CISTERNAL PORTION OF THE OCULOMOTOR NERVE ON MR IMAGING SO AMERICAN JOURNAL OF NEURORADIOLOGY LA English DT Article DE NERVES, OCULOMOTOR (III); CONTRAST MEDIA, PARAMAGNETIC; NERVES, ANATOMY; MIGRAINE ID FACIAL-NERVE; OPHTHALMOPLEGIC MIGRAINE; PALSY; DYSFUNCTION AB PURPOSE: To describe a radiographic finding-enhancement of the cisternal portion of the third cranial nerve on postcontrast MR-and to correlate it with patients' clinical symptoms and ultimate diagnosis. MATERIALS AND METHODS: Thirteen consecutive patients with enhancement of the cisternal portion of the third cranial nerve on postcontrast MR were retrospectively identified; 50 control patients referred for pituitary microadenomas were also retrospectively reviewed. FINDINGS: The enhancement was bilateral in six patients and unilateral in seven patients. Four of the six patients with bilateral enhancement had unilateral oculomotor nerve palsies; none had bilateral third cranial nerve palsy. Five of the seven patients with unilateral enhancement had ipsilateral third nerve palsies. Of the nine patients with third nerve palsies, the pupil was involved in four patients. Follow-up studies were available in six patients, four of whom had third nerve palsy. Resolution of the enhancement correlated with resolution of the symptoms in two patients. The patients' underlying diagnoses were lymphoma (four), leukemia (one), viral meningitis (one), neurofibromatosis (two), inflammatory polyneuropathy-HIV related (one), ophthalmoplegic migraine (one), Tolosa-Hunt syndrome (one), coccidioidomycosis (one), and diabetes (one). No enhancement was seen in any of the controls. CONCLUSION: Enhancement of the cisternal segment of the third cranial nerve is always abnormal, revealing an underlying inflammatory or neoplastic process. However, it is not always associated with clinically apparent oculomotor nerve dysfunction. C1 WASHINGTON HOSP CTR,DEPT MED,WASHINGTON,DC 20010. WASHINGTON HOSP CTR,DEPT OPHTHALMOL,WASHINGTON,DC 20010. HOSP UNIV PENN,PHILADELPHIA,PA 19104. STANFORD UNIV HOSP,STANFORD,CA 94305. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. RP MARK, AS (reprint author), WASHINGTON HOSP CTR,DEPT RADIOL,110 IRVING ST NW,WASHINGTON,DC 20010, USA. NR 18 TC 66 Z9 68 U1 1 U2 1 PU AMER SOC NEURORADIOLOGY PI OAK BROOK PA 2210 MIDWEST RD, OAK BROOK, IL 60521 SN 0195-6108 J9 AM J NEURORADIOL JI Am. J. Neuroradiol. PD SEP-OCT PY 1992 VL 13 IS 5 BP 1463 EP 1470 PG 8 WC Clinical Neurology; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging GA JN798 UT WOS:A1992JN79800035 PM 1414843 ER PT J AU MURPHY, TP AF MURPHY, TP TI RHINORRHEA AFTER NEUROTOLOGIC SURGERY SO AMERICAN JOURNAL OF OTOLOGY LA English DT Article ID CEREBROSPINAL-FLUID RHINORRHEA; CISTERNOGRAPHY; METRIZAMIDE; DIAGNOSIS; MANAGEMENT; FISTULAS AB Rhinorrhea after neurotologic surgery may be indicative of a cerebrospinal fluid (CSF) leak or may be secondary to autonomic dysfunction as a result of injury to preganglionic parasympathetic fibers. Differentiation between these two conditions is essential because undetected CSF rhinorrhea may lead to meningitis and death. C1 BROOKE ARMY MED CTR,DEPT EAR NOSE & THROAT,FT SAM HOUSTON,TX 78234. NR 16 TC 3 Z9 3 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0192-9763 J9 AM J OTOL JI Am. J. Otol. PD SEP PY 1992 VL 13 IS 5 BP 474 EP 476 PG 3 WC Otorhinolaryngology SC Otorhinolaryngology GA JM982 UT WOS:A1992JM98200015 PM 1443084 ER PT J AU EICHINGER, MR CLAYBAUGH, JR AF EICHINGER, MR CLAYBAUGH, JR TI HYPOXIA ATTENUATES THE RENIN RESPONSE TO HEMORRHAGE SO AMERICAN JOURNAL OF PHYSIOLOGY LA English DT Article DE ARGININE VASOPRESSIN; PLASMA RENIN ACTIVITY; ATRIAL NATRIURETIC FACTOR ID VASOPRESSIN; ANGIOTENSIN; PRESSURE; PEPTIDE; RELEASE; HORMONE; MECHANISM; HYPOXEMIA; SYSTEM; DOGS AB We studied hypoxia and hypotensive hemorrhage in conscious female goats. After control, goats continued an experimental period in normoxia or hypoxia [fractional inspired oxygen concentration (FI(O2)) = 0.10] for 120 min. After 60 min in the experimental period, a hemorrhage (0.5 ml . kg-1 . min-1 for 30 min) was initiated (normoxic hemorrhage, NH; hypoxic hemorrhage, HH). Heart rate (HR) increased 51 +/- 18 beats/min with NH after 30 min of hemorrhage. HR increased 40 +/- 10 beats/min after hypoxic gas introduction, with no further increase during HH. Mean arterial blood pressure (MABP) was reduced 23 +/- 7 mmHg 30 min after completion of blood loss with normoxia but was reduced 23 +/- 7 mmHg at 20 min of HH. Arginine vasopressin (AVP) was increased to 2.60 +/- 2.08 and 160.40 +/- 49.74 muU/ml after 10 and 20 min of HH, respectively, and was only increased after 30 min (87.33 +/- 67.18 muU/ml) of NH. Unexpectedly, plasma renin activity (PRA) increased in parallel in both groups and was doubled at 30 min of hemorrhage. Atrial natriuretic factor was reduced to 8.8 +/- 1.6 pg/ml by 10 min of NH and to 11.4 +/- 3.3 pg/ml at 30 min of HH. Thus hypoxia leads to an earlier development of hypotension and increase in AVP with blood loss but may attenuate the PRA response to blood pressure reduction. C1 TRIPLER ARMY MED CTR,DEPT CLIN INVEST,HONOLULU,HI 96859. UNIV HAWAII,DEPT PHYSIOL,HONOLULU,HI 96822. NR 30 TC 5 Z9 5 U1 0 U2 0 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0002-9513 J9 AM J PHYSIOL JI Am. J. Physiol. PD SEP PY 1992 VL 263 IS 3 BP R664 EP R669 PN 2 PG 6 WC Physiology SC Physiology GA JP902 UT WOS:A1992JP90200083 PM 1415656 ER PT J AU KLIMSTRA, DS HEFFESS, CS OERTEL, JE ROSAI, J AF KLIMSTRA, DS HEFFESS, CS OERTEL, JE ROSAI, J TI ACINAR CELL-CARCINOMA OF THE PANCREAS - A CLINICOPATHOLOGICAL STUDY OF 28 CASES SO AMERICAN JOURNAL OF SURGICAL PATHOLOGY LA English DT Review DE ACINAR CELL CARCINOMA; PANCREAS ID PAPILLARY EPITHELIAL NEOPLASM; SERUM ALPHA-FETOPROTEIN; EXOCRINE PANCREAS; ELECTRON-MICROSCOPY; CYSTIC NEOPLASM; TRANSGENIC MICE; NON-ENDOCRINE; PANCREATOBLASTOMA; TUMORS; CLASSIFICATION AB We have examined the microscopic appearance, immunohistochemical staining properties, and clinical behavior of 28 cases of acinar cell carcinoma of the pancreas. Two of the tumors occurred in children. The adult patients ranged in age from 40 to 81 years (mean, 62 years). Males greatly outnumbered females, and most of the patients were white. Presenting symptoms were nonspecific, and jaundice was infrequent. The frequently reported complications from increased serum lipase levels (i.e., arthralgias and subcutaneous fat necrosis) were present in only 16% of the patients. Grossly, the tumors were relatively circumscribed and fleshy, averaging 10.8 cm, with occasionally extensive hemorrhage and necrosis. Microscopically, the tumors were very cellular and characteristically lacked a desmoplastic stroma. Acinar, solid, trabecular, and glandular patterns of growth were identified; individual tumors were usually mixed. Nuclei were round to oval, with minimal pleomorphism and single prominent nucleoli. Mitotic activity was variable. In general the cytoplasm was moderately abundant, eosinophilic, and granular, but many of the solid tumors had cells with scanty cytoplasm. Characteristic periodic acid-Schiff-positive, diastase-resistant cytoplasmic granules were demonstrated in >90% of the cases, and the butyrate esterase histochemical stain for lipase activity was positive in 73%. Immunohistochemically, there was positivity for trypsin in 100% of the cases, for lipase in 77%, for chymotrypsin in 38%, and for amylase in 31%. A minor endocrine component was recognized with antibodies against chromogranin or islet cell hormones in 42% of the tumors. Ultrastructurally, exocrine secretory features were present, with polarized cells showing microvilli-lined lumina, abundant rough endoplasmic reticulum, and 125-1,000-nm zymogen-like granules. In addition, many cases showed pleomorphic electron-dense granules measuring up to 3,500 nm and containing fibrillary internal structures. Follow-up information was available in 88% of the cases. Half of the patients had metastatic disease at presentation and an additional 23% subsequently developed metastases, which were usually restricted to the regional lymph nodes and liver. The mean survival for all cases was 18 months, with 1- and 3-year survivals of 57 and 26%, respectively. Patients presenting before age 60 years survived nearly twice as long as older patients did. Stage also influenced prognosis, whereas the histologic subtype of the tumors and the location within the pancreas correlated only weakly with survival. C1 YALE UNIV,SCH MED,DEPT PATHOL,NEW HAVEN,CT 06510. USA,INST PATHOL,DEPT ENDOCRINE PATHOL,WASHINGTON,DC 20310. NR 102 TC 271 Z9 280 U1 0 U2 2 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0147-5185 J9 AM J SURG PATHOL JI Am. J. Surg. Pathol. PD SEP PY 1992 VL 16 IS 9 BP 815 EP 837 DI 10.1097/00000478-199209000-00001 PG 23 WC Pathology; Surgery SC Pathology; Surgery GA JR437 UT WOS:A1992JR43700001 PM 1384374 ER PT J AU WENIG, BM HITCHCOCK, CL ELLIS, GL GNEPP, DR AF WENIG, BM HITCHCOCK, CL ELLIS, GL GNEPP, DR TI METASTASIZING MIXED TUMOR OF SALIVARY-GLANDS - A CLINICOPATHOLOGICAL AND FLOW CYTOMETRIC ANALYSIS SO AMERICAN JOURNAL OF SURGICAL PATHOLOGY LA English DT Article DE METASTASIZING MIXED TUMORS; SALIVARY GLAND; FLOW CYTOMETRY; MIXED TUMORS ID BENIGN PLEOMORPHIC ADENOMA; SMOOTH-MUSCLE TUMORS; PROLIFERATIVE ACTIVITY; PAROTID-GLAND; DNA CONTENT; CLINICAL BEHAVIOR; CARCINOMA; UTERUS; MYOEPITHELIOMA; ANEUPLOIDY AB Among salivary gland neoplasms are a group of rare tumors that are histologically identical to benign mixed tumors that inexplicably metastasize; they have been called metastasizing mixed tumor (MZMT) of salivary glands. We report the clinicopathologic features and flow cytometric findings for 11 cases of MZMT. At the time of discovery of metastatic disease, the patients, six women and five men, ranged in age from 20 to 83 years. Primary sites of involvement included the parotid gland (eight cases), submandibular gland (two cases), and the nasal septum (one case). With one exception, all the patients had at least a single recurrence of their primary mixed tumor, but two or more recurrences were the norm before development of metastatic foci. The metastases were discovered from six to 52 years following the occurrence of the primary tumor. Metastatic deposits were identified in bone, lung, regional lymph nodes, skin, kidney, retroperitoneum, oral cavity, pharynx, calvarium, and central nervous system. The metastases either occurred simultaneously with an episode of recurrent mixed tumor (n = 5) or from 5 to 29 years after a recurrence (n = 6). The treatment of the primary, recurrent, and metastatic neoplasms was surgical excision. Follow-up, ranging from 8 months to 16 years following the diagnosis of MZMT, revealed seven patients to be alive without disease (64%) and two dead of causes unrelated to metastatic disease (18%). Two patients (18%) died as a direct result of metastatic tumor at 3 and 2 years after metastasis of their mixed tumors. Flow cytometric analysis revealed a diploid DNA cell population in the primary and/or metastatic tumors in nine cases. Aneuploid DNA cell content was identified in two of the cases. DNA ploidy levels and cell proliferation rates were compared with those of conventional benign mixed tumors and also with malignant mixed tumors. Retrospective analysis of histologic parameters (mitotic rate, cellular pleomorphism, infiltrative growth, vascular or lymphatic invasion) and flow cytometric analysis failed to identify criteria to predict the development of metastasis in these neoplasms. C1 USA,INST PATHOL,DEPT CELLULAR PATHOL,WASHINGTON,DC 20306. USA,INST PATHOL,DEPT ORAL PATHOL,WASHINGTON,DC 20306. RHODE ISL HOSP,DEPT PATHOL,PROVIDENCE,RI 02902. RP WENIG, BM (reprint author), USA,INST PATHOL,DEPT OTOLARYNG ENDOCRINE PATHOL,WASHINGTON,DC 20306, USA. NR 74 TC 73 Z9 77 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0147-5185 J9 AM J SURG PATHOL JI Am. J. Surg. Pathol. PD SEP PY 1992 VL 16 IS 9 BP 845 EP 858 DI 10.1097/00000478-199209000-00003 PG 14 WC Pathology; Surgery SC Pathology; Surgery GA JR437 UT WOS:A1992JR43700003 PM 1384375 ER PT J AU WILLIAMS, SB FOSS, RD ELLIS, GL AF WILLIAMS, SB FOSS, RD ELLIS, GL TI INFLAMMATORY PSEUDOTUMORS OF THE MAJOR SALIVARY-GLANDS - CLINICOPATHOLOGICAL AND IMMUNOHISTOCHEMICAL ANALYSIS OF 6 CASES SO AMERICAN JOURNAL OF SURGICAL PATHOLOGY LA English DT Article DE INFLAMMATORY PSEUDOTUMOR; PAROTID GLAND ID PLASMA-CELL GRANULOMA; LYMPH-NODES; INTERLEUKIN-1; PROLIFERATION; HISTIOCYTOMA; MESENTERY; LESIONS AB Inflammatory pseudotumor is a pathologic term used to describe reactive, pseudoneoplastic phenomena, which reportedly occur in many parts of the body. Clinicopathologic and immunohistochemical findings in six cases of inflammatory pseudotumor of the major salivary glands are described. All six lesions involved the parotid gland. There were three men and three women affected, with a median age of 72.5 years. All patients presented with a swelling of several months' duration in the parotid region. Five patients were alive and free of tumor at an average of 3.2 years after surgical removal, and one patient was lost to follow-up. The lesions were firm, discrete nodules, grossly described as homogenous yellow-gray tissue. Histologically, all lesions contained a diversified admixture of four histological elements: (a) myofibroblasts, (b) histiocytes, (c) plasma cells, and (d) lymphocytes. Results of immunohistochemical studies showed a biphasic spindle cell population of myofibroblasts and histiocytes with variable staining characteristics for KP-1(CD-3), smooth muscle actin, muscle-specific actin, and vimentin. These findings are in agreement with the concept that inflammatory pseudotumor is a fibroinflammatory lesion with an abundant component of myofibroblastic/fibrohistiocytic elements. C1 USA,INST PATHOL,VET AFFAIRS SPECIAL REFERENCE LAB PATHOL,WASHINGTON,DC 20306. RP WILLIAMS, SB (reprint author), USA,INST PATHOL,DEPT ORAL PATHOL,WASHINGTON,DC 20306, USA. NR 30 TC 53 Z9 53 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0147-5185 J9 AM J SURG PATHOL JI Am. J. Surg. Pathol. PD SEP PY 1992 VL 16 IS 9 BP 896 EP 902 DI 10.1097/00000478-199209000-00008 PG 7 WC Pathology; Surgery SC Pathology; Surgery GA JR437 UT WOS:A1992JR43700008 PM 1415908 ER PT J AU TACKET, CO BINION, SB BOSTWICK, E LOSONSKY, G ROY, MJ EDELMAN, R AF TACKET, CO BINION, SB BOSTWICK, E LOSONSKY, G ROY, MJ EDELMAN, R TI EFFICACY OF BOVINE-MILK IMMUNOGLOBULIN CONCENTRATE IN PREVENTING ILLNESS AFTER SHIGELLA-FLEXNERI CHALLENGE SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID ESCHERICHIA-COLI; ROTAVIRUS GASTROENTERITIS; ORAL VACCINATION; SONNEI VACCINE; PROTECTION; IMMUNIZATION; CANDIDATE; COLOSTRUM; IMMUNITY; ANTIBODIES AB The protective efficacy of oral bovine immunoglobulin concentrates derived from colostrum against challenge with Shigella flexneri was studied in healthy adult volunteers in a randomized, double-blind fashion. Volunteers were given a product consisting of hyperimmune immunoglobulin concentrate with a high titer of anti-S. flexneri 2a lipopolysaccharide (LPS) with sodium bicarbonate or a control preparation with sodium bicarbonate three times a day for seven days. On the third day of treatment, volunteers received a challenge of 10(3) colony-forming units of S. flexneri 2a strain 2457T. None of the volunteers who received the high-titered hyperimmune product became ill, compared with 45% of volunteers who received the placebo (P < 0.05). The duration of shedding of the challenge organism was decreased, and the active immune responses to S. flexneri LPS were less frequent and of lower magnitude in volunteers given the immunoglobulin concentrate than in those in the control group. High-titered, orally administered bovine immunoglobulin concentrate protects against shigellosis and may be useful in preventing shigellosis among travelers, military personnel, and individuals at risk during a Shigella outbreak. C1 GALAGEN INC,MINNEAPOLIS,MN 55440. USA,MED MAT DEV ACT,FT DETRICK,MD 21702. RP TACKET, CO (reprint author), UNIV MARYLAND,SCH MED,DEPT MED,CTR VACCINE DEV,10 S PINE ST,BALTIMORE,MD 21201, USA. NR 28 TC 122 Z9 124 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD SEP PY 1992 VL 47 IS 3 BP 276 EP 283 PG 8 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA JQ927 UT WOS:A1992JQ92700003 PM 1524140 ER PT J AU OGERT, RA BROWN, JE SINGH, BR SHRIVERLAKE, LC LIGLER, FS AF OGERT, RA BROWN, JE SINGH, BR SHRIVERLAKE, LC LIGLER, FS TI DETECTION OF CLOSTRIDIUM-BOTULINUM TOXIN-A USING A FIBER OPTIC-BASED BIOSENSOR SO ANALYTICAL BIOCHEMISTRY LA English DT Article ID ANTIBODY-BASED IMMUNOASSAY; TETANUS C1 UNIV MASSACHUSETTS,DEPT CHEM,DARTMOUTH,MA 02747. USA,MED RES INST INFECT DIS,DEPT PATHOL,FREDERICK,MD 21701. RP OGERT, RA (reprint author), USN,RES LAB,CTR BIOMOLEC SCI & ENGN,WASHINGTON,DC 20375, USA. NR 23 TC 112 Z9 116 U1 0 U2 9 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0003-2697 J9 ANAL BIOCHEM JI Anal. Biochem. PD SEP PY 1992 VL 205 IS 2 BP 306 EP 312 DI 10.1016/0003-2697(92)90440-I PG 7 WC Biochemical Research Methods; Biochemistry & Molecular Biology; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA JM682 UT WOS:A1992JM68200019 PM 1443578 ER PT J AU BAUMGARTEN, RK OLSON, DW OFFNER, PJ WESEN, CA AF BAUMGARTEN, RK OLSON, DW OFFNER, PJ WESEN, CA TI EPIDURAL-ANESTHESIA AND ANALGESIA IN VASCULAR-SURGERY SO ANESTHESIA AND ANALGESIA LA English DT Letter RP BAUMGARTEN, RK (reprint author), BROOKE ARMY MED CTR,DEPT SURG,FT SAM HOUSTON,TX 78234, USA. NR 7 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0003-2999 J9 ANESTH ANALG JI Anesth. Analg. PD SEP PY 1992 VL 75 IS 3 BP 464 EP 465 PG 2 WC Anesthesiology SC Anesthesiology GA JK361 UT WOS:A1992JK36100034 PM 1342785 ER PT J AU UKETY, TO KAIMBO, K NELSON, AM MOUSSA, G PARYSVANGINDERDEUREN, R VANDEPITTE, J AF UKETY, TO KAIMBO, K NELSON, AM MOUSSA, G PARYSVANGINDERDEUREN, R VANDEPITTE, J TI CONJUNCTIVAL RHINOSPORIDIOSIS - REPORT OF 3 CASES FROM ZAIRE SO ANNALES DE LA SOCIETE BELGE DE MEDECINE TROPICALE LA English DT Article DE CRYPTOSPORIDIUM-SEEBERI; CONJUNCTIVAL RHINOSPORIDIOSIS; ZAIRE AB The authors report three cases of conjunctival rhinosporidiosis from Zaire, two Of which are believed to be the first documented in the northeastern part of the country. All patients were males. Two patients were very young children, respectively 5 and 6 years old. The third patient was a 35-year-old man. The diagnosis was based on histopathology which revealed the characteristic features of Rhinosporidium seeberi. Total excision was the elective treatment. The disease recurred eleven months later in one case, probably from local dissemination of the parasite during surgery. C1 CTR MED EVANGEL,PROJET OPHTALMOL,NYANKUNDE,ZAIRE. CLIN UNIV KINSHASA,SERV OPHTALMOL,KINSHASA 1,ZAIRE. PROJET SIDA,SERV ANATOMOPATHOL,KINSHASA 1,ZAIRE. USA,INST PATHOL,AIDS REGISTRY,WASHINGTON,DC 20306. UNIV HOSP ST RAPHAEL,B-3000 LOUVAIN,BELGIUM. UNIV IOWA,DEPT OPHTHALMOL,EYE PATHOL LAB,IOWA CITY,IA 52242. NR 13 TC 3 Z9 3 U1 0 U2 0 PU N V CEUTERICK PI LOUVAIN PA BRUSSELSESTRAAT 153, B-3000 LOUVAIN, BELGIUM SN 0365-6527 J9 ANN SOC BELG MED TR JI Ann. Soc. Belg. Med. Trop. PD SEP PY 1992 VL 72 IS 3 BP 219 EP 223 PG 5 WC Tropical Medicine SC Tropical Medicine GA KF858 UT WOS:A1992KF85800007 PM 1476471 ER PT J AU BJORNSON, DC OSTER, CN CORTESE, LM NELSON, BA AF BJORNSON, DC OSTER, CN CORTESE, LM NELSON, BA TI AEROSOLIZED PENTAMIDINE AND PNEUMOCYSTIS-CARINII PNEUMONIA - PATIENT COMPLIANCE AND OUTCOMES SO ANNALS OF PHARMACOTHERAPY LA English DT Article ID PROPHYLAXIS; TRIAL; AIDS; COST AB OBJECTIVE: The study objectives were to compare compliance between every-two-week and every four week aerosolized pentamidine regimens, and to determine if patients who were more compliant with the use of aerosolized pentamidine were at decreased risk for developing Pneumocystis carinii pneumonia (PCP). DESIGN: Nonrandomized observational study of patients receiving aerosolized pentamidine for PCP prophylaxis using the hospital pharmacy computer system to document aerosolized pentamidine use and compliance, and the Patient Administration Division's computer to document cases of PCP. SETTING: Tertiary care, US Army medical center. PATIENTS: All patients who were prescribed aerosolized pentamidine (60 mg every two weeks, 300 mg every four weeks, or both) over a 3.5-year period. MAIN OUTCOME MEASURES: Mean percent compliance was determined and compared between every two-week and every-four-week regimens. The relationship between compliance and cases of PCP was determined using nonparametric statistics. RESULTS: Patients (n=146) who were prescribed aerosolized pentamidine 60 mg every two weeks were more compliant (p=006) than those prescribed 300 mg every four weeks. In addition, those patients who initially received die 60-mg regimen and were switched to die 300-mg regimen were more compliant when taking the 60-mg dose (p=0.027). There was no association between compliance with either regimen and cases of PCP. Compliance generally was poor with both regimens. CONCLUSIONS: Patients on every-two-week regimens of aerosolized pentamidine were more compliant than those on every-four-week regimens. However, regardless of compliance, some patients failed aerosolized pentamidine over the 3.5-year period. Other agents that lend themselves to compliance may be more appropriate for PCP prophylaxis than aerosolized pentamidine. C1 WALTER REED ARMY MED CTR, WASHINGTON, DC 20307 USA. HENRY M JACKSON FDN ADV MIL MED, INFECT DIS SERV, ROCKVILLE, MD USA. NR 17 TC 3 Z9 3 U1 0 U2 0 PU HARVEY WHITNEY BOOKS CO PI CINCINNATI PA PO BOX 42696, CINCINNATI, OH 45242 SN 1060-0280 J9 ANN PHARMACOTHER JI Ann. Pharmacother. PD SEP PY 1992 VL 26 IS 9 BP 1066 EP 1070 PG 5 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA JN534 UT WOS:A1992JN53400001 PM 1421665 ER PT J AU MOSS, JT WILSON, JP AF MOSS, JT WILSON, JP TI TREATMENT OF VIRAL HEMORRHAGIC FEVERS WITH RIBAVIRIN SO ANNALS OF PHARMACOTHERAPY LA English DT Letter ID NOSOCOMIAL OUTBREAK C1 USA,OFF SURGEON GEN,FALLS CHURCH,VA. RP MOSS, JT (reprint author), US ACAD HLTH SCI,DIV MED SURG,PHARM BRANCH,FT SAM HOUSTON,TX 78234, USA. NR 18 TC 0 Z9 0 U1 0 U2 0 PU HARVEY WHITNEY BOOKS CO PI CINCINNATI PA PO BOX 42696, CINCINNATI, OH 45242 SN 1060-0280 J9 ANN PHARMACOTHER JI Ann. Pharmacother. PD SEP PY 1992 VL 26 IS 9 BP 1156 EP 1157 PG 2 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA JN534 UT WOS:A1992JN53400024 PM 1421687 ER PT J AU BERGER, BJ NAIMAN, NA HALL, JE PEGGINS, J BREWER, TG TIDWELL, RR AF BERGER, BJ NAIMAN, NA HALL, JE PEGGINS, J BREWER, TG TIDWELL, RR TI PRIMARY AND SECONDARY METABOLISM OF PENTAMIDINE BY RATS SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID PNEUMOCYSTIS-CARINII PNEUMONIA; LIQUID-CHROMATOGRAPHIC METHOD; LIVER; PHARMACOKINETICS; HYDROXYLATION; ISETHIONATE AB The antiprotozoal drug pentamidine [1,5-bis(4'-amidinophenoxy)pentane] has been previously shown to be metabolized by rat liver microsomes, and five of the seven putative primary metabolites have been identified. With the synthesis and identification of 5-(4'-amidinophenoxy)pentanoic acid and 5-(4'-amidinophenoxy)-1-pentanol pentanol as the remaining two metabolites, the primary metabolism of pentamidine in rats appears fully characterized. Use of [C-14]pentamidine with rat liver microsomes confirms this conclusion, since no unidentified radioactive peaks were detected by high-performance liquid chromatography (HPLC). Isolated, perfused rat livers were used with [C-14]pentamidine to identify secondary metabolites. Only two novel radioactive peaks were detected by HPLC analysis of perfused liver samples. The treatment of liver samples with sulfatase or beta-glucuronidase resulted in the reduction or elimination of these peaks and gave rise to peaks identified as para-hydroxybenzamidine and 5-(4'-amidinophenoxy)pentanoic acid. It was concluded from these results that only these two primary metabolites were conjugated with sulfate or glucuronic acid. After 4 h of incubation in the perfused liver system, approximately 15% of the recovered radiolabel was pentamidine. These results suggest that pentamidine metabolism can be rapid and extensive in rats. C1 UNIV N CAROLINA,DEPT PATHOL,CHAPEL HILL,NC 27599. UNIV N CAROLINA,DEPT PARASITOL & LAB PRACTICE,CHAPEL HILL,NC 27599. UNIV N CAROLINA,DEPT EPIDEMIOL,CHAPEL HILL,NC 27599. WALTER REED ARMY MED CTR,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307. FU NIAID NIH HHS [AI 32912, N01-AI-72648] NR 25 TC 45 Z9 45 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD SEP PY 1992 VL 36 IS 9 BP 1825 EP 1831 PG 7 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA JM247 UT WOS:A1992JM24700006 PM 1416874 ER PT J AU BERMAN, JD KSIONSKI, G CHAPMAN, WL WAITS, VB HANSON, WL AF BERMAN, JD KSIONSKI, G CHAPMAN, WL WAITS, VB HANSON, WL TI ACTIVITY OF AMPHOTERICIN-B CHOLESTEROL DISPERSION (AMPHOCIL) IN EXPERIMENTAL VISCERAL LEISHMANIASIS SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID ANTILEISHMANIAL ACTIVITY; HAMSTERS AB Standard therapy of human visceral leishmaniasis with parenteral pentavalent antimonial agents is generally curative but has the disadvantages of a 28-day treatment course, occasional treatment failures, and toxicity. The antifungal and antileishmanial agent amphotericin B has been complexed with lipids to develop a less toxic formulation of amphotericin B. Because lipid particles are phagocytized by the reticuloendothelial system, lipid-associated amphotericin B should be concentrated in infected macrophages and be very effective against visceral leishmaniasis. One formulation, amphotericin B cholesterol dispersion (ABCD) (Amphocil), was tested for antileishmanial activity in Leishmania donovani-infected hamsters. In the first experiment, hamsters were infected, administered with the drug 3 days later, and then sacrificed after a further 4 days. ABCD {dose needed to suppress 99% of hepatic parasites compared with controls [SD (99)], 0.4 mg/kg of body weight} was 15 times as effective as conventional amphotericin B [SD (99), 6.0 mg/kg]. Pentavalent antimony in the form of meglumine antimonate had an SD (84) of 416 mg/kg. In a second experiment in which animals were allowed to become more heavily infected, the drug was administered 10 days after infection and the animals were sacrificed after a further 2, 7, or 11 days. ABCD was approximately four times as active as conventional amphotericin B. These experiments suggest that ABCD is at least four times as active as conventional amphotericin B against visceral leishmaniasis and that clinical trials are warranted. C1 LIPOSOME TECHNOL INC,MENLO PK,CA 94025. UNIV GEORGIA,COLL VET MED,DEPT PARASITOL,ATHENS,GA 30602. RP BERMAN, JD (reprint author), WALTER REED ARMY MED CTR,WASHINGTON,DC 20307, USA. NR 11 TC 39 Z9 40 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD SEP PY 1992 VL 36 IS 9 BP 1978 EP 1980 PG 3 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA JM247 UT WOS:A1992JM24700030 PM 1416890 ER PT J AU MARIN, R SPELLMAN, N KENYON, M BELANDRES, PV AF MARIN, R SPELLMAN, N KENYON, M BELANDRES, PV TI ISOKINETIC EXERCISE SYSTEM MODIFICATION FOR SHORT BELOW-THE-KNEE RESIDUAL LIMBS SO ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION LA English DT Article DE BELOW-THE-KNEE AMPUTEE; ISOKINETIC; SHORT; STRENGTH ID STRENGTH AB The use of isokinetic exercise has been shown to be an effective way of strengthening debilitated muscles. In the below the knee amputee, significant quadriceps and hamstring muscle wasting has been documented. Although isokinetic strengthening of the debilitated knee extensors and flexors in the below the knee amputee would be beneficial, there are no fully described isokinetic equipment modifications in literature that would allow a short below the knee amputee to effectively use isokinetic equipment. This article describes such a modification. RP MARIN, R (reprint author), WALTER REED ARMY MED CTR,PHYS MED & REHABIL SERV,WASHINGTON,DC 20307, USA. NR 6 TC 1 Z9 1 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0003-9993 J9 ARCH PHYS MED REHAB JI Arch. Phys. Med. Rehabil. PD SEP PY 1992 VL 73 IS 9 BP 883 EP 885 PG 3 WC Rehabilitation; Sport Sciences SC Rehabilitation; Sport Sciences GA JM347 UT WOS:A1992JM34700023 PM 1514900 ER PT J AU LIPNICK, RN SFIKAKIS, PP KLIPPLE, GL TSOKOS, GC AF LIPNICK, RN SFIKAKIS, PP KLIPPLE, GL TSOKOS, GC TI ELEVATED SOLUBLE CD8 (SCD8) ANTIGEN AND SOLUBLE INTERLEUKIN-2 RECEPTOR (SIL-2R) IN JUVENILE RHEUMATOID-ARTHRITIS (JRA) SO ARTHRITIS AND RHEUMATISM LA English DT Meeting Abstract C1 UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,CNMC,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0004-3591 J9 ARTHRITIS RHEUM JI Arthritis Rheum. PD SEP PY 1992 VL 35 IS 9 SU S BP S93 EP S93 PG 1 WC Rheumatology SC Rheumatology GA JR158 UT WOS:A1992JR15800344 ER PT J AU SFIKAKIS, PP TESAR, J LIPNICK, RN AMSTRONG, J KLIPPLE, GL TSOKOS, GC AF SFIKAKIS, PP TESAR, J LIPNICK, RN AMSTRONG, J KLIPPLE, GL TSOKOS, GC TI ELEVATED SERUM LEVELS OF SOLUBLE INTERCELLULAR-ADHESION MOLECULE-1 (ICAM-1) IN PATIENTS WITH SYSTEMIC-SCLEROSIS (SS) SO ARTHRITIS AND RHEUMATISM LA English DT Meeting Abstract C1 UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. CHILDRENS NATL MED CTR,WASHINGTON,DC. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0004-3591 J9 ARTHRITIS RHEUM JI Arthritis Rheum. PD SEP PY 1992 VL 35 IS 9 SU S BP S237 EP S237 PG 1 WC Rheumatology SC Rheumatology GA JR158 UT WOS:A1992JR15801197 ER PT J AU SFIKAKIS, PP TESAR, J THEOCHARIS, S DOUVAS, A LIPNICK, RN KLIPPLE, GL TSOKOS, GC AF SFIKAKIS, PP TESAR, J THEOCHARIS, S DOUVAS, A LIPNICK, RN KLIPPLE, GL TSOKOS, GC TI ISOLATION OF INVIVO MUTATED T-CELL CLONES FROM THE PERIPHERAL-BLOOD OF PATIENTS WITH SYSTEMIC-SCLEROSIS (SS) SO ARTHRITIS AND RHEUMATISM LA English DT Meeting Abstract C1 UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. UNIV SO CALIF,LOS ANGELES,CA 90089. WALTER REED ARMY MED CTR,CNMC,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0004-3591 J9 ARTHRITIS RHEUM JI Arthritis Rheum. PD SEP PY 1992 VL 35 IS 9 SU S BP S38 EP S38 PG 1 WC Rheumatology SC Rheumatology GA JR158 UT WOS:A1992JR15800021 ER PT J AU VOGELGESANG, S HEYES, MP SALAZAR, AM SFIKAKIS, PP LIPNICK, RN KLIPPLE, GL TSOKOS, GC AF VOGELGESANG, S HEYES, MP SALAZAR, AM SFIKAKIS, PP LIPNICK, RN KLIPPLE, GL TSOKOS, GC TI QUINOLINIC ACID (QA) LEVELS IN THE CEREBROSPINAL-FLUID (CSF) OF PATIENTS WITH SYSTEMIC LUPUS-ERYTHEMATOSUS (SLE) - PATHOGENETIC AND CLINICAL-SIGNIFICANCE SO ARTHRITIS AND RHEUMATISM LA English DT Meeting Abstract C1 UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. CHILDRENS HOSP,NATL MED CTR,WASHINGTON,DC 20010. NIMH,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0004-3591 J9 ARTHRITIS RHEUM JI Arthritis Rheum. PD SEP PY 1992 VL 35 IS 9 SU S BP S60 EP S60 PG 1 WC Rheumatology SC Rheumatology GA JR158 UT WOS:A1992JR15800155 ER PT J AU GREENWALT, DE LIPSKY, RH OCKENHOUSE, CF IKEDA, H TANDON, NN JAMIESON, GA AF GREENWALT, DE LIPSKY, RH OCKENHOUSE, CF IKEDA, H TANDON, NN JAMIESON, GA TI MEMBRANE GLYCOPROTEIN-CD36 - A REVIEW OF ITS ROLES IN ADHERENCE, SIGNAL TRANSDUCTION, AND TRANSFUSION MEDICINE SO BLOOD LA English DT Review ID FALCIPARUM-INFECTED ERYTHROCYTES; HUMAN-PLATELET MEMBRANE; COLLAGEN-INDUCED AGGREGATION; MEGAKARYOBLASTIC CELL-LINE; HUMAN-BLOOD PLATELETS; PLASMODIUM-FALCIPARUM; MONOCLONAL-ANTIBODIES; ENDOTHELIAL-CELLS; IV CD36; MYELOPROLIFERATIVE DISORDERS C1 AMER RED CROSS,CELL BIOL LAB,15601 CRABBS BRANCH WAY,ROCKVILLE,MD 20855. HOKKAIDO RED CROSS BLOOD CTR,SAPPORO,JAPAN. WALTER REED ARMY MED CTR,DEPT IMMUNOL,WASHINGTON,DC 20307. OI Lipsky, Robert/0000-0001-7753-1473 FU NHLBI NIH HHS [HL38664, HL40858] NR 122 TC 420 Z9 431 U1 1 U2 9 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0006-4971 J9 BLOOD JI Blood PD SEP 1 PY 1992 VL 80 IS 5 BP 1105 EP 1115 PG 11 WC Hematology SC Hematology GA JL367 UT WOS:A1992JL36700001 PM 1381234 ER PT J AU PATTANAPANYASAT, K WEBSTER, HK TONGTAWE, P KONGCHAROEN, P HIDER, RC AF PATTANAPANYASAT, K WEBSTER, HK TONGTAWE, P KONGCHAROEN, P HIDER, RC TI EFFECT OF ORALLY ACTIVE HYDROXYPYRIDINONE IRON CHELATORS ON HUMAN LYMPHOCYTE FUNCTION SO BRITISH JOURNAL OF HAEMATOLOGY LA English DT Article ID PERIPHERAL-BLOOD LYMPHOCYTES; DNA-SYNTHESIS; TRANSFERRIN RECEPTORS; BETA-THALASSEMIA; CELL ACTIVATION; MOUSE MODEL; DESFERRIOXAMINE; PROLIFERATION; EXPRESSION; INHIBITION AB Several iron chelators, 3-hydroxypyridin-4-ones (CP) and desferrioxamine (DF) were compared for their effect on DNA synthesis, cell viability and expression of cell proliferation markers. Short-term (4 h) exposure of human peripheral blood mononuclear cells to CP or DF inhibited the proliferative response of cells to concanavalin A (Con A). Inhibition by CP and DF showed a dose-dependent effect with CP compounds more active than DF. Increased inhibitory activity of CP over DF was partly due to the lipophilic properties of CP. Pre-saturation of CP and DF with exogenous ferric ion either diminished or prevented the inhibitory effect. At high chelator concentrations or prolonged (72 h) exposure of the cells to chelators, inhibition occurred but poor cell viability was observed. In contrast to their inhibition of DNA synthesis, these iron chelators showed little effect on protein synthesis and the expression of transferrin receptors and interleukin-2 (IL-2) receptors. These findings suggest that both DF and CP compounds exert their effect by chelation of ferric ion with subsequent inhibition of DNA synthesis. C1 ARMED FORCES RES INST MED SCI,DEPT IMMUNOL & BIOCHEM,BANGKOK,THAILAND. UNIV LONDON KINGS COLL,DEPT PHARM,LONDON WC2R 2LS,ENGLAND. RP PATTANAPANYASAT, K (reprint author), MAHIDOL UNIV,SIRIRAJ HOSP,FAC GRAD STUDIES,DIV HAEMATOL,CTR THALASSAEMIA,BANGKOK 10700,THAILAND. FU NHLBI NIH HHS [HL 34408] NR 33 TC 13 Z9 13 U1 0 U2 1 PU BLACKWELL SCIENCE LTD PI OXFORD PA OSNEY MEAD, OXFORD, OXON, ENGLAND OX2 0EL SN 0007-1048 J9 BRIT J HAEMATOL JI Br. J. Haematol. PD SEP PY 1992 VL 82 IS 1 BP 13 EP 19 DI 10.1111/j.1365-2141.1992.tb04587.x PG 7 WC Hematology SC Hematology GA JM254 UT WOS:A1992JM25400003 PM 1419787 ER PT J AU BASKIN, SI FRICKE, RF AF BASKIN, SI FRICKE, RF TI THE PHARMACOLOGY OF P-AMINOPROPIOPHENONE IN THE DETOXIFICATION OF CYANIDE SO CARDIOVASCULAR DRUG REVIEWS LA English DT Review DE CYANIDE; METHEMOGLOBIN; P-AMINOPROPIOPHENONE; METHEMOGLOBINEMIA ID METHEMOGLOBIN PRODUCTION; PAPP; ANTIDOTE; BLOOD; 4-DIMETHYLAMINOPHENOL; 4-AMINOPROPIOPHENONE; DIMETHYLAMINOPHENOL; PHARMACOKINETICS; PROTECTION; KINETICS C1 USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010. NR 107 TC 12 Z9 12 U1 1 U2 2 PU NEVA PRESS PI BRANFORD PA P O BOX 347, BRANFORD, CT 06405 SN 0897-5957 J9 CARDIOVASC DRUG REV JI Cardiovasc. Drug Rev. PD FAL PY 1992 VL 10 IS 3 BP 358 EP 375 DI 10.1111/j.1527-3466.1992.tb00256.x PG 18 WC Cardiac & Cardiovascular Systems; Pharmacology & Pharmacy SC Cardiovascular System & Cardiology; Pharmacology & Pharmacy GA KD855 UT WOS:A1992KD85500007 ER PT J AU MORRIS, JT MCALLISTER, CK AF MORRIS, JT MCALLISTER, CK TI HOMELESS INDIVIDUALS AND DRUG-RESISTANT TUBERCULOSIS IN SOUTH TEXAS SO CHEST LA English DT Article AB Drug-resistant tuberculosis was found in 21 percent , homeless individuals in New York City between 1982 an 1987. To see if this relationship existed in south Texas, evaluated all admissions to a Texas Health Department facility with culture-proven tuberculosis. Four hundred forty-three patients were admitted between September 1987 and October 1990. Twenty-six, (5.9 percent) of these patients were identified as homeless. Alcoholism, tobacco abuse, divorce, and unemployment were common demographic characteristics. Six male patients and one female patient (27 percent) had Mycobacterium tuberculosis resistant to one or more antituberculosis drugs. Five were Hispanic, one was white, and one was black. The six male patients had resistance to only one drug, either rifampin or ethambutol. The female patient had resistance to streptomycin, isoniazid, and rifampin. These findings illustrate that drug-resistant tuberculosis exists among homeless individuals in south Texas. As the number of homeless people increases, physicians need to recognize that pulmonary tuberculosis is a frequent infection in this population and that the causal mycobacteria may well be resistant to one or more antituberculosis agents. C1 BROOKE ARMY MED CTR,INFECT DIS SERV,FT SAM HOUSTON,TX 78234. NR 10 TC 16 Z9 16 U1 0 U2 1 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 SN 0012-3692 J9 CHEST JI Chest PD SEP PY 1992 VL 102 IS 3 BP 802 EP 804 DI 10.1378/chest.102.3.802 PG 3 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA JL857 UT WOS:A1992JL85700030 PM 1516406 ER PT J AU WELLS, C BERTSCH, W PERICH, M AF WELLS, C BERTSCH, W PERICH, M TI ISOLATION OF VOLATILES WITH INSECTICIDAL PROPERTIES FROM THE GENUS TAGETES (MARIGOLD) SO CHROMATOGRAPHIA LA English DT Article DE GAS CHROMATOGRAPHY; NATURAL INSECTICIDES; MARIGOLDS; ISOLATION OF VOLATILES ID ALPHA-TERTHIENYL; MOSQUITO; LARVAE; MINUTA; OIL AB The results of optimizing Soxhlet and Simultaneous Distillation-Extraction (SSDE) procedures for the isolation of natural insecticides from Tagetes erecta, Tagetes patula, and Tagetes minuta, members of the Compositae family, are presented. Extraction procedures were developed and validated that produced the extract with the highest degree of biocidal activity. The highest activity was obtained with extracts isolated by SSDE using methylene chloride. Initial work was carried out on a micro-SSDE. Preparative SSDE was used to provide large quantities of extracts for bioassays. Bioassays were used to govern optimization procedures using Aedes aegypti and Anopheles stephensi adults and larvae as target organisms. Tagetes minuta was determined to be the most active of the three species studied. Evaluation of activity and recovery versus extraction time was investigated. It was determined that an extraction time of ten hours resulted in the highest activity and over 90 % recovery of the oils. Finally, supercritical fluid extraction of the flowers with CO2 was compared to SSDE. C1 UNIV ALABAMA,DEPT CHEM,TUSCALOOSA,AL 35487. USA,BIOMED RES & DEV LAB,FREDERICK,MD 21702. NR 29 TC 20 Z9 21 U1 0 U2 3 PU FRIEDR VIEWEG SOHN VERLAG GMBH PI WIESBADEN 1 PA PO BOX 5829, W-6200 WIESBADEN 1, GERMANY SN 0009-5893 J9 CHROMATOGRAPHIA JI Chromatographia PD SEP-OCT PY 1992 VL 34 IS 5-8 BP 241 EP 248 DI 10.1007/BF02268352 PG 8 WC Biochemical Research Methods; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA JP110 UT WOS:A1992JP11000006 ER PT J AU ROBERTSON, WG AF ROBERTSON, WG TI CIVIL-WAR VIRGINIA - BATTLEGROUND FOR A NATION - ROBERTSON,JI SO CIVIL WAR HISTORY LA English DT Book Review RP ROBERTSON, WG (reprint author), USA,ARMAMENT RES & DEV COMMAND,DOVER,NJ 07801, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU KENT STATE UNIV PRESS PI KENT PA C/O JOURNALS DEPT, KENT, OH 44242 SN 0009-8078 J9 CIVIL WAR HIST JI Civil War Hist. PD SEP PY 1992 VL 38 IS 3 BP 247 EP 249 PG 3 WC History SC History GA JJ164 UT WOS:A1992JJ16400007 ER PT J AU MARTIN, TW SEAWORTH, JF JOHNS, JP AF MARTIN, TW SEAWORTH, JF JOHNS, JP TI COMPARISON OF EXERCISE ELECTROCARDIOGRAPHY AND DOBUTAMINE ECHOCARDIOGRAPHY SO CLINICAL CARDIOLOGY LA English DT Article DE DOBUTAMINE; EXERCISE TEST; ECHOCARDIOGRAPHY; CORONARY ARTERY DISEASE ID CORONARY-ARTERY DISEASE; ACUTE MYOCARDIAL-INFARCTION; INFUSION AB It is uncertain whether dobutamine echocardiography is a better test than exercise electrocardiography for the detection of coronary disease in patients who can exercise. We compared the hemodynamics, sensitivity, and specificity of these tests in 24 patients, 16 with coronary disease and 8 controls. The tests were performed within six weeks of one another and were interpreted without knowledge of other clinical data. The exercise electrocardiogram was considered abnormal if the patient developed one mm of ST-segment depression, while the dobutamine test (up to 40-mu-g/kg/min) was considered abnormal if the patient developed ST-segment depression or a left ventricular wall motion abnormality. Exercise testing resulted in a higher heart rate (145+/-29 vs. 110+/-24, p<0.001) and blood pressure (176+/-31 vs. 148+/-24, p<0.001). Dobutamine testing Was 25% more sensitive than exercise testing (94 vs. 69%, 95% confidence interval for difference is 0 to 50%, p=0.09), while exercise testing was 38% more specific (88 vs. 50%, 95% confidence interval for difference is -3 to 79%, p=0.14). We conclude that exercise results in a higher heart rate and blood pressure than dobutamine infusion. Differences in sensitivity and specificity are inconclusive, but indicate that the sensitivity of exercise testing is, at best, equivalent to dobutamine testing, while any increase in specificity with dobutamine testing, compared with exercise testing, would not be clinically significant. C1 BROOKE ARMY MED CTR,CARDIOL SERV,FT SAM HOUSTON,TX 78234. NR 16 TC 13 Z9 13 U1 0 U2 0 PU CLINICAL CARDIOLOGY PUBL CO PI MAHWAH PA PO BOX 832, MAHWAH, NJ 07430-0832 SN 0160-9289 J9 CLIN CARDIOL JI Clin. Cardiol. PD SEP PY 1992 VL 15 IS 9 BP 641 EP 646 PG 6 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA JL405 UT WOS:A1992JL40500005 PM 1395198 ER PT J AU SPITZER, RE STITZEL, AE TSOKOS, G AF SPITZER, RE STITZEL, AE TSOKOS, G TI ON THE ORIGIN OF C3 NEPHRITIC FACTOR (ANTIBODY TO THE ALTERNATIVE PATHWAY C3-CONVERTASE) - EVIDENCE FOR THE ADAM AND EVE CONCEPT OF AUTOANTIBODY PRODUCTION SO CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY LA English DT Review ID APPARENT RESTRICTED USE; T-CELLS; MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS; NUCLEOTIDE-SEQUENCES; INTERNAL IMAGE; DNA ANTIBODY; VH FAMILIES; B-CELLS; COMPLEMENT; ANTIGEN C1 UNIFORMED SERV UNIV HLTH SCI,WALTER REED ARMY MED CTR,DEPT MED,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. RP SPITZER, RE (reprint author), SUNY HLTH SCI CTR,DEPT PEDIAT,SYRACUSE,NY 13210, USA. NR 33 TC 20 Z9 20 U1 0 U2 0 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0090-1229 J9 CLIN IMMUNOL IMMUNOP JI Clin. Immunol. Immunopathol. PD SEP PY 1992 VL 64 IS 3 BP 177 EP 183 DI 10.1016/0090-1229(92)90197-V PG 7 WC Immunology; Pathology SC Immunology; Pathology GA JJ838 UT WOS:A1992JJ83800001 PM 1386563 ER PT J AU CALLAGHAN, JJ HEEKIN, RD SAVORY, CG DYSART, SH HOPKINSON, WJ AF CALLAGHAN, JJ HEEKIN, RD SAVORY, CG DYSART, SH HOPKINSON, WJ TI EVALUATION OF THE LEARNING-CURVE ASSOCIATED WITH UNCEMENTED PRIMARY POROUS-COATED ANATOMIC TOTAL HIP-ARTHROPLASTY SO CLINICAL ORTHOPAEDICS AND RELATED RESEARCH LA English DT Article ID LUMINAL CORONARY ANGIOPLASTY AB The results of the first and second groups of 50 consecutive primary, uncemented porous-coated anatomic arthroplasties were analyzed to evaluate the learning curve associated with the procedure. Femoral fit, acetabular cup angle, femoral fracture rate, minimum two-year clinical hip ratings, and clinical symptoms were compared between the two groups. Significant improvement in achieving better femoral canal filling with the prosthesis and lower acetabular cup angle placements was documented in the second 50 cases. Although a definite learning curve in mastering the technique of uncemented total hip arthroplasty was observed, thigh pain rate and clinical ratings were not improved after two years. C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 15 TC 22 Z9 22 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0009-921X J9 CLIN ORTHOP RELAT R JI Clin. Orthop. Rel. Res. PD SEP PY 1992 IS 282 BP 132 EP 144 PG 13 WC Orthopedics; Surgery SC Orthopedics; Surgery GA JM402 UT WOS:A1992JM40200017 PM 1516304 ER PT J AU BLAISDELL, GL BORLAND, SL AF BLAISDELL, GL BORLAND, SL TI PRELIMINARY-STUDY OF THE EFFECT OF FINES ON SANDED-ICE FRICTION SO COLD REGIONS SCIENCE AND TECHNOLOGY LA English DT Article AB Small-scale laboratory tests were performed on sanded ice. Four standard sands, as specified by various regulatory agencies, were tested. Sliding friction was measured for a rubber-faced slider for each sand type at a temperature of -10-degrees-C on three prepared surfaces: bare ice, loose sanded ice and ice with sand frozen on. We found friction coefficients for bare ice to be higher than those measured on loosely sanded ice and, in some cases, on ice with sand frozen on. Test results, presented as a performance ratio (ratio of coefficients for sanded ice to bare ice), allowed a distinct ranking of the sands' effectiveness. Performance ratios for frozen-on sand were significantly greater than for loose sand for a given sand type. The performance ratio showed a strong, linearly increasing trend as the percentage of a given fine grain size in the sand was increased. We found that this line had a steeper slope for the percentage of material smaller than 0.177 mm as compared with that smaller than 0.297 mm. Also, there were greater increases in traction with increases in fines for frozen-on sand as compared with loosely sanded ice. RP BLAISDELL, GL (reprint author), USA,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 11 TC 2 Z9 2 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-232X J9 COLD REG SCI TECHNOL JI Cold Reg. Sci. Tech. PD SEP PY 1992 VL 21 IS 1 BP 79 EP 90 DI 10.1016/0165-232X(92)90007-H PG 12 WC Engineering, Environmental; Engineering, Civil; Geosciences, Multidisciplinary SC Engineering; Geology GA JX866 UT WOS:A1992JX86600006 ER PT J AU FIELDS, D KIM, TJ AF FIELDS, D KIM, TJ TI APPLICATION OF A COMPUTER-AIDED EXPERT DECISION SUPPORT SYSTEM TO RURAL-DEVELOPMENT IN KENYA SO COMPUTERS ENVIRONMENT AND URBAN SYSTEMS LA English DT Article AB This paper describes the utility of a computer-aided system that couples an expert system with other planning modeling techniques and hypermedia as a method to support institutional development. Using an example of rural development in Kenya, the paper describes the application of a computer-aided expert decision support system to aid local planners and administrators plan for investment in infrastructure to selected rural service centers. C1 UNIV ILLINOIS,DEPT URBAN & REG PLANNING,URBANA,IL 61801. RP FIELDS, D (reprint author), USA CORPS ENGINEERS,OFF STRATEG INITIAT,WASHINGTON,DC, USA. NR 14 TC 1 Z9 1 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0198-9715 J9 COMPUT ENVIRON URBAN JI Comput. Environ. Urban Syst. PD SEP-OCT PY 1992 VL 16 IS 5 BP 415 EP 433 DI 10.1016/0198-9715(92)90003-A PG 19 WC Computer Science, Interdisciplinary Applications; Engineering, Environmental; Environmental Studies; Geography; Operations Research & Management Science SC Computer Science; Engineering; Environmental Sciences & Ecology; Geography; Operations Research & Management Science GA JM400 UT WOS:A1992JM40000003 ER PT J AU BERNARD, RS AF BERNARD, RS TI A MACCORMACK SCHEME FOR INCOMPRESSIBLE-FLOW SO COMPUTERS & MATHEMATICS WITH APPLICATIONS LA English DT Article ID EQUATIONS AB MacCormack's explicit predictor-corrector scheme is extended for incompressible flow on marker-and-cell grids. Cell-centered velocities are first constructed by taking a normal velocity component from one of two possible cell faces for each coordinate direction. The predictor phase then proceeds in the usual manner employed for cell-centered grids. Central differencing is used for diffusion terms, and one-sided differencing (in the same direction as the face-to-center velocity transfer) is used for advective terms. At the end of the predictor phase, cell-centered velocity increments are transferred back to the cell faces from which the normal velocity components were taken, and the pressure is adjusted to enforce conservation of mass. The corrector phase follows the same pattern, but the directions for the face-to-center velocity transfer and the one-sided differencing are the reverse of those in the predictor. The extended MacCormack method requires only one control volume to be defined for each grid cell. This affords the convenience of a cell-centered scheme with the tight mass conservation of a staggered grid. Computed results are presented for a straight channel, a driven cavity, a backstep, and a circular cylinder. RP BERNARD, RS (reprint author), USA ENGINEER,WATERWAYS EXPT STN,DIV HYDRAUL STRUCT,VICKSBURG,MS 39180, USA. NR 17 TC 3 Z9 3 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0898-1221 J9 COMPUT MATH APPL JI Comput. Math. Appl. PD SEP PY 1992 VL 24 IS 5-6 BP 151 EP 168 DI 10.1016/0898-1221(92)90046-K PG 18 WC Mathematics, Applied SC Mathematics GA JF269 UT WOS:A1992JF26900011 ER PT J AU ROSENBERGER, L AF ROSENBERGER, L TI ECONOMIC TRANSITION IN EASTERN-EUROPE - PAYING THE PRICE FOR FREEDOM SO EAST EUROPEAN QUARTERLY LA English DT Article RP ROSENBERGER, L (reprint author), USA,WAR COLL,CARLISLE BARRACKS,PA 17013, USA. NR 69 TC 0 Z9 0 U1 0 U2 0 PU EAST EUROPEAN QUARTERLY PI BOULDER PA BOX 29 REGENT HALL UNIV COLORADO, BOULDER, CO 80309 SN 0012-8449 J9 E EUR QUART JI East European Q. PD FAL PY 1992 VL 26 IS 3 BP 261 EP 278 PG 18 WC Area Studies SC Area Studies GA JM095 UT WOS:A1992JM09500001 ER PT J AU FISICARO, SA LAUTENSCHLAGER, GJ AF FISICARO, SA LAUTENSCHLAGER, GJ TI POWER AND RELIABILITY - THE CASE OF HOMOGENEOUS TRUE SCORE REGRESSION ACROSS TREATMENTS SO EDUCATIONAL AND PSYCHOLOGICAL MEASUREMENT LA English DT Article ID SIGNIFICANCE TESTS; DIFFERENCE SCORES; PARADOX AB As part of their investigation of the relation between reliability of measures and statistical power, Nicewander and Price (1983) examined the situation in which true score regressions are homogeneous across treatments. They derived an equation indicating that the measure, X or Y, yielding the greater power depends on the reliabilities (rho(XX') and rho(YY'), respectively) and the squared linear correlation between true scores for X and Y (rho(T(X)T(Y))2). Typically, however, researchers cannot compute a direct estimate of rho(T(X)T(Y))2. The authors eliminate this problem by (a) pointing out situations in which the value of rho(T(X)T(Y))2 is either irrelevant or 1.0 and (b) demonstrating that their equation otherwise can be expressed in terms of rho(XX') and rho(XY) only. C1 USA,RES INST,FIELD UNIT,FT KNOX,KY 40121. UNIV GEORGIA,ATHENS,GA 30602. RP FISICARO, SA (reprint author), WAYNE STATE UNIV,DEPT PSYCHOL,71 W WARREN AVE,DETROIT,MI 48202, USA. NR 11 TC 2 Z9 2 U1 0 U2 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 SN 0013-1644 J9 EDUC PSYCHOL MEAS JI Educ. Psychol. Meas. PD FAL PY 1992 VL 52 IS 3 BP 505 EP 511 DI 10.1177/0013164492052003001 PG 7 WC Psychology, Educational; Mathematics, Interdisciplinary Applications; Psychology, Mathematical SC Psychology; Mathematics GA JP138 UT WOS:A1992JP13800001 ER PT J AU HEWITT, AD CRAGIN, JH AF HEWITT, AD CRAGIN, JH TI A STUDY OF THE LINEAR RANGES OF SEVERAL ACID DIGESTION PROCEDURES - COMMENT SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Letter ID SOLID-WASTES; SEDIMENTS; SLUDGES; SOILS RP HEWITT, AD (reprint author), COLD REGIONS RES & ENGN LAB,HANOVER,NH 03755, USA. NR 3 TC 3 Z9 3 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0013-936X J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD SEP PY 1992 VL 26 IS 9 BP 1848 EP 1848 DI 10.1021/es00033a025 PG 1 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA JL086 UT WOS:A1992JL08600030 ER PT J AU MCARDLE, WD TONER, MM MAGEL, JR SPINA, RJ PANDOLF, KB AF MCARDLE, WD TONER, MM MAGEL, JR SPINA, RJ PANDOLF, KB TI THERMAL RESPONSES OF MEN AND WOMEN DURING COLD-WATER IMMERSION - INFLUENCE OF EXERCISE INTENSITY SO EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY AND OCCUPATIONAL PHYSIOLOGY LA English DT Article DE THERMOREGULATION; COLD; REST; GENDER; EXERCISE ID ADJUSTMENT; TEMPERATURE; EXPOSURE AB The influence of exercise intensity on thermoregulation was studied in 8 men and 8 women volunteers during three levels of arm-leg exercise (level I: 700 ml oxygen (O2).min-1; level II: 1250 ml O2.min-1; level III: 1700 ml O2.min-1) for 1 h in water at 20 and 28-degrees-C (T(w)). For the men in T(w) 28-degrees-C the rectal temperature (T(re)) fell 0.79-degrees-C (P < 0.05) during immersion in both rest and level-I exercise. With level-II exercise a drop in T(re) of 0.54-degrees-C (P < 0.05) was noted, while at level-III exercise T(re) did not change from the pre-immersion value. At T(w) of 20-degrees-C, T(re) fell throughout immersion with no significant difference in final T(re) observed between rest and any exercise level. For the women at rest at T(w) 28-degrees-C, T(re) fell 0.80-degrees-C (P < 0.05) below the pre-immersion value. With the two more intense levels of exercise, T(re) did not decrease during immersion. In T(w) 20-degrees-C, the women maintained higher T(re) (P < 0.05) during level-II and level-III exercise compared to rest and exercise at level I. The T(re) responses were related to changes in tissue insulation (I(t)) between rest and exercise with the largest reductions in I(t) noted between rest and level-I exercise across T(w) and gender. For men and women of similar percentage body fat, decreases in T(re) were greater for the women at rest and level-I exercise in T(w) 20-degrees-C (P < 0.05). With more intense exercise, the women maintained a higher T(re) than the men, especially in the colder water. These findings indicate that exercise is not always effective in offsetting the decrease in I(t) and facilitated heat loss in cool or cold water compared to rest. The factors of exercise intensity, T(w), body fat, and gender influence the thermoregulatory responses. C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. RP MCARDLE, WD (reprint author), CUNY QUEENS COLL,DEPT HLTH & PHYS EDUC,APPL PHYSIOL LAB,FLUSHING,NY 11367, USA. NR 30 TC 30 Z9 33 U1 4 U2 14 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0301-5548 J9 EUR J APPL PHYSIOL O JI Eur. J. Appl. Physiol. Occup. Physiol. PD SEP PY 1992 VL 65 IS 3 BP 265 EP 270 DI 10.1007/BF00705092 PG 6 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA JN906 UT WOS:A1992JN90600011 PM 1396657 ER PT J AU DELALLA, F EZZELL, JW PELLIZZER, G PARENTI, E VAGLIA, A MARRANCONI, F TRAMARIN, A AF DELALLA, F EZZELL, JW PELLIZZER, G PARENTI, E VAGLIA, A MARRANCONI, F TRAMARIN, A TI FAMILIAL OUTBREAK OF AGRICULTURAL ANTHRAX IN AN AREA OF NORTHERN ITALY SO EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES LA English DT Note AB Three cases of cutaneous anthrax are reported which occurred in a farming family in northern Italy. Epidemiological studies revealed contact with an infected cow (delivery of a stillborn fetus and slaughter). The cow was slaughtered soon after the delivery; cultures of carcass specimens yielded growth of Bacillus anthracis. The origin of the animal infection was not known. Serum samples were obtained from all 11 members of the family group and randomly from 10 of the 75 cows on the farm, which appeared to be in good health. Tests for antibodies against protective antigen and lethal factor using EIA and Western blot techniques were positive in three subjects (in paired sera) with cutaneous anthrax and in one subject who neither had had direct contact with the infected cow nor showed any sign of anthrax. C1 OSPED SAN BORTOLO,DIV MALATTIE INFETT,VIA RODOLFI,I-36100 VICENZA,ITALY. IST ZOOPROFILATT SPERIMENTALE VENEZIE,SEZ VICENZA,I-36100 VICENZA,ITALY. USA,INFECT DIS RES INST,DIV BACTERIOL,FREDERICK,MD 21702. NR 10 TC 4 Z9 4 U1 0 U2 1 PU FRIEDR VIEWEG SOHN VERLAG GMBH PI WIESBADEN 1 PA PO BOX 5829, W-6200 WIESBADEN 1, GERMANY SN 0934-9723 J9 EUR J CLIN MICROBIOL JI Eur. J. Clin. Microbiol. Infect. Dis. PD SEP PY 1992 VL 11 IS 9 BP 839 EP 842 PG 4 WC Infectious Diseases; Microbiology SC Infectious Diseases; Microbiology GA KA331 UT WOS:A1992KA33100013 PM 1468425 ER PT J AU COHAN, CF KADAKIA, SC KADAKIA, AS AF COHAN, CF KADAKIA, SC KADAKIA, AS TI SERUM ELECTROLYTE, MINERAL, AND BLOOD-PH CHANGES AFTER PHOSPHATE ENEMA, WATER ENEMA, AND ELECTROLYTE LAVAGE SOLUTION ENEMA FOR FLEXIBLE SIGMOIDOSCOPY SO GASTROINTESTINAL ENDOSCOPY LA English DT Article ID HYPOCALCEMIC TETANY; HYPERPHOSPHATEMIA; ABSORPTION; INFANT; COMA AB Hypertonic sodium phosphate (Fleet(R)) enema is a commonly used preparation for fiberoptic flexible sigmoidoscopy. Unfortunately, Fleet(R) has been associated with complications in children and adults. The purpose of this study was to compare the serum electrolytes, mineral, and blood pH changes before and after the administration of Fleet(R) with water and polyethylene glycol electrolyte lavage solution (Golytely(R)) as enemas in an adult population undergoing flexible sigmoidoscopy. Sixty-six patients were randomized in a double-blind fashion to receive two enemas of either Fleet(R) (N = 22), water (N = 20), or Golytely(R) (N = 24). The cleansing ability was graded from 1 to 4 (1 = poor, 4 = excellent). The Fleet(R) had significantly better optimal cleansing efficacy compared with water (p < 0.05) but not to Golytely(R) (p > 0.05). There was a significant increase in the serum phosphorus in the Fleet(R) group compared with water (p < 0.001) or Golytely(R) (p < 0.001). However, absolute serum phosphorus values after Fleet(R) enema always remained within normal range in all but one patient. The changes in other electrolytes, minerals, and venous pH were insignificant. C1 BROOKE ARMY MED CTR,DEPT MED,GASTROENTEROL SERV,FT SAM HOUSTON,TX 78234. NR 29 TC 26 Z9 26 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0016-5107 J9 GASTROINTEST ENDOSC JI Gastrointest. Endosc. PD SEP-OCT PY 1992 VL 38 IS 5 BP 575 EP 578 DI 10.1016/S0016-5107(92)70520-3 PG 4 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA JT930 UT WOS:A1992JT93000011 PM 1397914 ER PT J AU KADAKIA, SC AF KADAKIA, SC TI VIRAL ESOPHAGITIS - THE ENDOSCOPIC APPEARANCE SO GASTROINTESTINAL ENDOSCOPY LA English DT Letter RP KADAKIA, SC (reprint author), BROOKE ARMY MED CTR,DEPT MED,GASTROENTEROL SERV,FT SAM HOUSTON,TX 78234, USA. NR 4 TC 0 Z9 1 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0016-5107 J9 GASTROINTEST ENDOSC JI Gastrointest. Endosc. PD SEP-OCT PY 1992 VL 38 IS 5 BP 633 EP 633 DI 10.1016/S0016-5107(92)70541-0 PG 1 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA JT930 UT WOS:A1992JT93000032 PM 1327939 ER PT J AU MOUL, JW THEUNE, SM CHANG, EH AF MOUL, JW THEUNE, SM CHANG, EH TI DETECTION OF RAS MUTATIONS IN ARCHIVAL TESTICULAR GERM-CELL TUMORS BY POLYMERASE CHAIN-REACTION AND OLIGONUCLEOTIDE HYBRIDIZATION SO GENES CHROMOSOMES & CANCER LA English DT Article ID ONCOGENES; ACTIVATION; CANCER; AMPLIFICATION; NEOPLASIA; GENES; LINES; VIRUS AB Preliminary studies of RAS mutational activation in human testicular germ cell neoplasms have yielded conflicting results. Whereas two studies of clinical material revealed a significant incidence of N- and KRAS mutations, two studies of a variety of germ cell lines failed to document RAS mutations. To clarify the incidence of RAS mutations in these tumors, we studied archival paraffin-embedded, formalin-fixed orchiectomy specimens from 25 nonseminomas (NSGCT), 18 seminomas (SEM), and one Leydig cell tumor. For 14 of the 44 neoplasms, DNA was also available from nonmalignant testis adjacent to the tumor. Six age-matched patients had testes removed because of nonmalignant disease and were studied as controls. Polymerase chain reaction (PCR) amplified the K-, N-, and HRAS 12, 13, and 61 codons of these specimens, and mutations were detected with mutation-specific oligonucleotide probe hybridization of Southern and slot blots. Four mutations were found in KRAS 12 (4/444;[9.1%]). One seminoma [1/18(5.6%)] contained the mutation GGT(GLY) --> CGT(ARG), and three NSGCT [3/25(12%)] were found to have GGT(GLY) --> GAT(ASP) mutations. One of the NSGCT mutations was detected in adjacent nonmalignant tissue, but the corresponding tumor did not contain any detectable mutation. No mutations were detected at KRAS 13 or 61, in NRAS or HRAS 12, 13, or 61, or in the control normal testes. PCR, slot blots, and hybridizations were performed twice by two separate investigators for confirmation of results. PCR-generated mutation-specific positive controls were created for all possible RAS mutations, and these along with wild-type DNA controls were integral to interpretation of the oligonucleotide mismatch hybridization assay. By using positive and negative controls, we have detected a relatively low incidence of RAS mutations in archival human testicular germ cell tumors. C1 UNIFORMED SERV UNIV HLTH SCI,DEPT PATHOL,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,UROL SERV,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. RP MOUL, JW (reprint author), UNIFORMED SERV UNIV HLTH SCI,DEPT SURG,4301 JONES BRIDGE RD,BETHESDA,MD 20814, USA. NR 24 TC 40 Z9 40 U1 0 U2 1 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 1045-2257 J9 GENE CHROMOSOME CANC JI Gene Chromosomes Cancer PD SEP PY 1992 VL 5 IS 2 BP 109 EP 118 DI 10.1002/gcc.2870050204 PG 10 WC Oncology; Genetics & Heredity SC Oncology; Genetics & Heredity GA JM782 UT WOS:A1992JM78200003 PM 1381946 ER PT J AU BARNHILL, D OCONNOR, D FARLEY, J TENERIELLO, M ARMSTRONG, D PARK, R AF BARNHILL, D OCONNOR, D FARLEY, J TENERIELLO, M ARMSTRONG, D PARK, R TI CLINICAL SURVEILLANCE OF GYNECOLOGIC CANCER-PATIENTS SO GYNECOLOGIC ONCOLOGY LA English DT Article ID SIGMOIDOSCOPY; CHEMOTHERAPY; PATTERNS; RELAPSE C1 WALTER REED ARMY MED CTR,DEPT OBSTET & GYNECOL,GYNECOL ONCOL SERV,WASHINGTON,DC 20307. BETHESDA NAVAL HOSP,DEPT CLIN INVEST,BETHESDA,MD 20814. NR 12 TC 39 Z9 39 U1 0 U2 0 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0090-8258 J9 GYNECOL ONCOL JI Gynecol. Oncol. PD SEP PY 1992 VL 46 IS 3 BP 275 EP 280 DI 10.1016/0090-8258(92)90216-6 PG 6 WC Oncology; Obstetrics & Gynecology SC Oncology; Obstetrics & Gynecology GA JQ941 UT WOS:A1992JQ94100003 PM 1526504 ER PT J AU GANDHI, OP GU, YG CHEN, JY BASSEN, HI AF GANDHI, OP GU, YG CHEN, JY BASSEN, HI TI SPECIFIC ABSORPTION RATES AND INDUCED CURRENT DISTRIBUTIONS IN AN ANATOMICALLY BASED HUMAN-MODEL FOR PLANE-WAVE EXPOSURES SO HEALTH PHYSICS LA English DT Article DE EXPOSURE, RADIOFREQUENCY; RADIATION, NONIONIZING; INDUCED CURRENTS; ELECTROMAGNETIC FIELDS ID TIME-DOMAIN METHOD; DIFFERENCE AB We have previously reported local, layer-averaged, and whole-body-averaged specific absorption rates and induced currents for a 5,628-cell anatomically based model of a human for plane-wave exposures 20-100 MHz (Chen and Gandhi 1989). Using a higher resolution, 45,024-cell model of the human body, calculations have now been extended to 915 MHz using the finite-difference time-domain method. Because of the higher resolution of the model, it has been possible to calculate specific absorption rates for various organs (brain, eyes, heart, lungs, liver, kidneys, and intestines) and for various parts of the body (head, neck, torso, legs, and arms) as a function of frequency in the band 100-915 MHz. Consistent with some of the experimental data in the literature, the highest part-body-averaged specific absorption rate for the head and neck region (as well as for the eyes and brain) occurs at 200 MHz for the isolated condition and at 150 MHz for the grounded condition of the model. Also observed is an increasing specific absorption rate for the eyes for frequencies above 350 MHz due to the superficial nature of power deposition at increasing frequencies. C1 WALTER REED ARMY MED CTR, DEPT MICROWAVE RES, WASHINGTON, DC 20307 USA. RP GANDHI, OP (reprint author), UNIV UTAH, DEPT ELECT ENGN, SALT LAKE CITY, UT 84112 USA. NR 12 TC 40 Z9 43 U1 0 U2 2 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0017-9078 EI 1538-5159 J9 HEALTH PHYS JI Health Phys. PD SEP PY 1992 VL 63 IS 3 BP 281 EP 290 DI 10.1097/00004032-199209000-00003 PG 10 WC Environmental Sciences; Public, Environmental & Occupational Health; Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical Imaging SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical Imaging GA JJ929 UT WOS:A1992JJ92900004 PM 1644564 ER PT J AU TURNER, BS AF TURNER, BS TI THE OTHER INTENSIVE-CARE UNIT SO HEART & LUNG LA English DT Editorial Material RP TURNER, BS (reprint author), USA,MADIGAN MED CTR,CLIN NURSING SERV,NURSE CORPS,TACOMA,WA 98431, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0147-9563 J9 HEART LUNG JI Heart Lung PD SEP-OCT PY 1992 VL 21 IS 5 BP 409 EP 410 PG 2 WC Cardiac & Cardiovascular Systems; Nursing; Respiratory System SC Cardiovascular System & Cardiology; Nursing; Respiratory System GA JQ490 UT WOS:A1992JQ49000001 PM 1399658 ER PT J AU ASHLEY, PR SORNSIN, EA AF ASHLEY, PR SORNSIN, EA TI DOPED OPTICAL CLADDINGS FOR WAVE-GUIDE DEVICES WITH ELECTROOPTICAL POLYMERS SO IEEE PHOTONICS TECHNOLOGY LETTERS LA English DT Article AB Optical claddings used with electrooptical polymer waveguides were doped with organic salts. The resulting decrease in resistivity was used to increase the electrical field strength across the electrooptical polymer. Relative poling fields were increased by a factor of 3.1 near the T(g) temperature, and the V(pi) was decreased by a factor of 2.8. C1 UNIV ALABAMA,DEPT PHYS,HUNTSVILLE,AL 35899. RP ASHLEY, PR (reprint author), USA,MISSILE COMMAND,CTR RES DEV & ENGN,AMSMI RD WS CM,WEAPONS SCI DIRECTORATE,REDSTONE ARSENAL,AL 35898, USA. NR 8 TC 15 Z9 15 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 1041-1135 J9 IEEE PHOTONIC TECH L JI IEEE Photonics Technol. Lett. PD SEP PY 1992 VL 4 IS 9 BP 1026 EP 1028 DI 10.1109/68.157137 PG 3 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA JP484 UT WOS:A1992JP48400027 ER PT J AU Koscica, TE Babbitt, R Hendrickson, M AF Koscica, Thomas E. Babbitt, Richard Hendrickson, Mary TI Increased Dielectric Quality Factor in Planar Resonators by Selective Dielectric Removal SO IEEE TRANSACTIONS ON APPLIED SUPERCONDUCTIVITY LA English DT Article AB A means is discussed for increasing the effective dielectric quality factor by selective removal of dielectric from a microstrip resonator. Methods for determining the impedance and effective dielectric constant are included. The reduction in loss compared with an equivalent microstrip resonator is presented. C1 [Koscica, Thomas E.; Babbitt, Richard; Hendrickson, Mary] US Army, SLCET MP, Ft Monmouth, NJ 07703 USA. RP Koscica, TE (reprint author), US Army, SLCET MP, Ft Monmouth, NJ 07703 USA. NR 6 TC 0 Z9 0 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI PISCATAWAY PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA SN 1051-8223 EI 1558-2515 J9 IEEE T APPL SUPERCON JI IEEE Trans. Appl. Supercond. PD SEP PY 1992 VL 2 IS 3 BP 186 EP 188 DI 10.1109/77.160160 PG 4 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA V30OB UT WOS:000208824200012 ER PT J AU HOLLAND, JA YAN, XH AF HOLLAND, JA YAN, XH TI OCEAN THERMAL FEATURE RECOGNITION, DISCRIMINATION, AND TRACKING USING INFRARED SATELLITE IMAGERY SO IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING LA English DT Article ID NEAR-SURFACE VELOCITY; EDGE-DETECTION AB This paper presents a method to quantitatively measure ocean surface movement, using sequential 10.8 mum band AVHRR images, developed at the University of Delaware in the spring of 1991. An ordered statistical edge detection algorithm is used to select ocean thermal pattern features by detecting and mapping gradients, at the same time discriminating between the water surface, land, and clouds. Use of edge detection to select features in this manner reduces the need to perform preprocess screening and masking to remove clouds and land. A constrained correlation based feature recognition scheme is then used to find the best match to the pattern feature in a subsequent image. Surface displacement direction and distance are calculated for each selected point with average period velocity being computed based on elapsed time. Study areas off the Delaware and New Jersey coast, and the California Current System off Northern California have been analyzed using this technique, with the results correlating favorably with in situ anchored buoy, and drifting buoy measurements. C1 UNIV DELAWARE,COLL MARINE STUDIES,CTR REMOTE SENSING,NEWARK,DE 19716. RP HOLLAND, JA (reprint author), USA,ARMY COMMUN ELECTR COMMAND,FT MONMOUTH,NJ 07703, USA. NR 27 TC 17 Z9 17 U1 0 U2 2 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0196-2892 J9 IEEE T GEOSCI REMOTE JI IEEE Trans. Geosci. Remote Sensing PD SEP PY 1992 VL 30 IS 5 BP 1046 EP 1053 DI 10.1109/36.175339 PG 8 WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote Sensing; Imaging Science & Photographic Technology SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science & Photographic Technology GA JZ984 UT WOS:A1992JZ98400022 ER PT J AU YANKIELUN, NE ARCONE, SA CRANE, RK AF YANKIELUN, NE ARCONE, SA CRANE, RK TI THICKNESS PROFILING OF FRESH-WATER ICE USING A MILLIMETER-WAVE FM-CW RADAR SO IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING LA English DT Note AB A prototype broadband millimeter wave (26.5 to 40 GHz) FM-CW radar employing digital signal processing techniques has been developed for profiling the thickness of freshwater ice. The radar was tested at elevations of up to 7 m above ice surfaces and at speeds up to 40 km/h both from a surface vehicle and a helicopter. The thickness of pond and river ice sheets between 3 and 35 cm thick with and without fresh snow cover and minimal surface roughness showed direct correlation with borehole thickness measurements. Losses due to volume scattering by imbedded air bubbles did not significantly affect system capability to discern the air/ice and ice/water scattering boundaries. C1 DARTMOUTH COLL,HANOVER,NH 03755. UNIV OKLAHOMA,NORMAN,OK 73019. RP YANKIELUN, NE (reprint author), USA,CRREL,HANOVER,NH 03755, USA. NR 13 TC 9 Z9 9 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0196-2892 J9 IEEE T GEOSCI REMOTE JI IEEE Trans. Geosci. Remote Sensing PD SEP PY 1992 VL 30 IS 5 BP 1094 EP 1100 DI 10.1109/36.175348 PG 7 WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote Sensing; Imaging Science & Photographic Technology SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science & Photographic Technology GA JZ984 UT WOS:A1992JZ98400031 ER PT J AU LEUPOLD, HA TILAK, AS POTENZIANI, E AF LEUPOLD, HA TILAK, AS POTENZIANI, E TI TAPERED FIELDS IN CYLINDRICAL AND SPHERICAL SPACES SO IEEE TRANSACTIONS ON MAGNETICS LA English DT Article; Proceedings Paper CT 1992 INTERNATIONAL MAGNETICS CONF ( INTERMAG 92 ) - MAGNETIC RECORDING HEADS : INDUCTIVE THIN FILM AND LAMINATED CY APR 13-16, 1992 CL ST LOUIS, MO SP ALLEGHENY LUDLUM, ALLIED SIGNAL, APPL MAGNET, BASF MAGNET, BOHLMAN TACHNET, CRUCIBLE MAGNET, EASTMAN KODAK, F G JONES ASSOC, FUJITSU, GEC ID PERMANENT-MAGNETS AB This paper shows how variations of a magnetic field along a cylindrical or spherical axis is effected for both longitudinal and transverse orientations. Field profiles in cylindrical structures of both orientations and various cross sections (square, octagonal and circular) are compared with each other and with a spherical shell source with a tapered longitudinal field. Methods of coping with field irregularities arising from architectural and materials compromises forced by operational peculiarities of particular devices are described and compared. RP LEUPOLD, HA (reprint author), USA,ELECTR TECHNOL & DEVICES LAB,FT MONMOUTH,NJ 07703, USA. NR 10 TC 3 Z9 4 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9464 J9 IEEE T MAGN JI IEEE Trans. Magn. PD SEP PY 1992 VL 28 IS 5 BP 3045 EP 3047 DI 10.1109/20.179712 PN 2 PG 3 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA JN877 UT WOS:A1992JN87700304 ER PT J AU LEUPOLD, HA POTENZIANI, E LOWRANCE, JL AF LEUPOLD, HA POTENZIANI, E LOWRANCE, JL TI PERMANENT-MAGNET STRUCTURES FOR XUV IMAGE SENSORS SO IEEE TRANSACTIONS ON MAGNETICS LA English DT Article; Proceedings Paper CT 1992 INTERNATIONAL MAGNETICS CONF ( INTERMAG 92 ) - MAGNETIC RECORDING HEADS : INDUCTIVE THIN FILM AND LAMINATED CY APR 13-16, 1992 CL ST LOUIS, MO SP ALLEGHENY LUDLUM, ALLIED SIGNAL, APPL MAGNET, BASF MAGNET, BOHLMAN TACHNET, CRUCIBLE MAGNET, EASTMAN KODAK, F G JONES ASSOC, FUJITSU, GEC ID FIELDS AB Several permanent magnet structures were designed to serve as light-weight, low-bulk field sources to guide the electron beams in X-ray/ultraviolet image sensors. All weigh approximately half kilogram or less compared to the presently employed structures of several kilograms. The field uniformity is of the order of a percent over the region traversed by the electron beam. C1 PRINCETON SCI INSTRUMENTS,MONMOUTH JCT,NJ 08852. RP LEUPOLD, HA (reprint author), USA,ELECTR TECHNOL & DEVICES LAB,FT MONMOUTH,NJ 07703, USA. NR 12 TC 0 Z9 0 U1 1 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9464 J9 IEEE T MAGN JI IEEE Trans. Magn. PD SEP PY 1992 VL 28 IS 5 BP 3048 EP 3050 DI 10.1109/20.179713 PN 2 PG 3 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA JN877 UT WOS:A1992JN87700305 ER PT J AU KLEIN, TA AKIN, DC YOUNG, DG AF KLEIN, TA AKIN, DC YOUNG, DG TI ULTRASTRUCTURE OF SPOROZOITES OF SCHELLACKIA-GOLVANI (EIMERIORINA, LANKESTERELLIDAE) IN THE GREEN ANOLE, ANOLIS-CAROLINENSIS SO INTERNATIONAL JOURNAL FOR PARASITOLOGY LA English DT Article DE ULTRASTRUCTURE; SPOROZOITES; SCHELLACKIA-GOLVANI; ANOLIS-CAROLINENSIS; LEUKOCYTES ID SURFACE-PROTEINS; PHAGOSOMES; SECRETION; HOST AB In the lizard host, Schellackia golvani sporozoites were observed in parasitophorous vacuoles of the polymorphonuclear series of leukocytes. Surrounding the parasite in the parasitophorous vacuole are numerous vesicles, intravascular tubules and electron-dense granules. The parasite envelope consists of a double membrane. A cytostome (micropyle), a conoid and apical rings are present. Paralamellate bodies, mitochondria, nucleus, nucleolus, rhopteries, micronemes and a single non-membrane-bound electron-lucid body were identified. The sporozoite subcellular morphology of S. golvani is similar to other sporozoan species belonging to the genera of Schellackia, Haemogregarina, Lankesterella, Eimeria and Toxoplasma. C1 UNIV FLORIDA,INST FOOD & AGR SCI,DEPT MICROBIOL & CELL SCI,GAINESVILLE,FL 32611. UNIV FLORIDA,INST FOOD & AGR SCI,DEPT ENTOMOL & NEMATOL,GAINESVILLE,FL 32611. RP KLEIN, TA (reprint author), WALTER REED ARMY MED CTR,DEPT ENTOMOL,DIV COMMUNICABLE DIS & IMMUNOL,WASHINGTON,DC 20307, USA. NR 15 TC 1 Z9 2 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0020-7519 J9 INT J PARASITOL JI Int. J. Parasit. PD SEP PY 1992 VL 22 IS 6 BP 767 EP 772 DI 10.1016/0020-7519(92)90126-6 PG 6 WC Parasitology SC Parasitology GA JQ959 UT WOS:A1992JQ95900009 ER PT J AU SKELTON, CDRHG SMITH, LTCKJ HOLLAND, CDRTT TOMASZEWSKI, MM LUPTON, GP AF SKELTON, CDRHG SMITH, LTCKJ HOLLAND, CDRTT TOMASZEWSKI, MM LUPTON, GP TI MALIGNANT SPITZ NEVUS SO INTERNATIONAL JOURNAL OF DERMATOLOGY LA English DT Article ID JUVENILE MELANOMA; MULTIPLE C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. RP SKELTON, CDRHG (reprint author), ARMED FORCES INST PATHOL,DEPT DERMATOPATHOL,WASHINGTON,DC 20306, USA. NR 17 TC 9 Z9 9 U1 0 U2 0 PU BLACKWELL SCIENCE LTD PI OXFORD PA OSNEY MEAD, OXFORD, OXON, ENGLAND OX2 0EL SN 0011-9059 J9 INT J DERMATOL JI Int. J. Dermatol. PD SEP PY 1992 VL 31 IS 9 BP 639 EP 641 DI 10.1111/j.1365-4362.1992.tb03984.x PG 3 WC Dermatology SC Dermatology GA JL082 UT WOS:A1992JL08200011 ER PT J AU AUSTIN, DM AF AUSTIN, DM TI THE UNIVERSITY-OF-MINNESOTA ARMY HIGH-PERFORMANCE COMPUTING RESEARCH-CENTER SO INTERNATIONAL JOURNAL OF SUPERCOMPUTER APPLICATIONS AND HIGH PERFORMANCE COMPUTING LA English DT Article RP AUSTIN, DM (reprint author), UNIV MINNESOTA,ARMY HIGH PERFORMANCE COMP RES CTR,1100 WASHINGTON AVE S,MINNEAPOLIS,MN 55415, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SAGE PUBLICATIONS INC PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 SN 1078-3482 J9 INT J SUPERCOMPUT AP JI Int. J. Supercomput. Appl. High Perform. Comput. PD FAL PY 1992 VL 6 IS 3 BP 215 EP 223 DI 10.1177/109434209200600301 PG 9 WC Computer Science, Hardware & Architecture; Computer Science, Interdisciplinary Applications SC Computer Science GA JV125 UT WOS:A1992JV12500001 ER PT J AU HOLLSTEN, DA AF HOLLSTEN, DA TI COMPLICATIONS OF LACRIMAL SURGERY SO INTERNATIONAL OPHTHALMOLOGY CLINICS LA English DT Article AB The lacrimal drainage apparatus exists to drain tears from the lacrimal lake to the inferior meatus of the nose. Simple in design, complicated in function, it works extremely well at its intended purpose for most people all their lives. Malfunction of the lacrimal drainage apparatus usually manifests itself with painless overflow tearing, also known as epiphora. To the uninvolved individual, epiphora seems like a relatively benign symptom, perhaps not worthy of much consideration. To the individual with pathological disturbance of the lacrimal drainage system causing epiphora, the constant overflow of tears may reach proportions resembling a form of torture. Because of this, many procedures have been described to treat the epiphora caused by the many pathological conditions involving the lacrimal drainage system. None of these procedures are perfect and without complications. The purpose of this chapter is to familiarize the physician briefly with the causes of and therapy for various conditions involving the lacrimal drainage system and then to discuss in more detail the potential complications of the various therapies. The lacrimal system also includes the main and accessory lacrimal glands. However, a discussion of the complications of surgical intervention for disorders of the lacrimal gland is beyond the scope of this chapter and is not included. RP HOLLSTEN, DA (reprint author), BROOKE ARMY MED CTR,OPHTHALMOL SERV,SAN ANTONIO,TX 78234, USA. NR 0 TC 8 Z9 8 U1 0 U2 0 PU LITTLE BROWN CO PI BOSTON PA 34 BEACON STREET, BOSTON, MA 02108-1493 SN 0020-8167 J9 INT OPHTHALMOL CLIN JI Int. Ophthalmol. Clin. PD FAL PY 1992 VL 32 IS 4 BP 49 EP 66 PG 18 WC Ophthalmology SC Ophthalmology GA JU631 UT WOS:A1992JU63100006 PM 1399351 ER PT J AU STEVENSON, CC CIBULL, DL PLATOFF, GE BUSH, DM GERE, JA AF STEVENSON, CC CIBULL, DL PLATOFF, GE BUSH, DM GERE, JA TI SOLID-PHASE EXTRACTION OF PHENCYCLIDINE FROM URINE FOLLOWED BY CAPILLARY GAS-CHROMATOGRAPHY MASS-SPECTROMETRY SO JOURNAL OF ANALYTICAL TOXICOLOGY LA English DT Note RP STEVENSON, CC (reprint author), USA,FORENS TOXICOL DRUG TESTING LAB,FT GEORGE G MEADE,MD 20755, USA. NR 3 TC 11 Z9 11 U1 0 U2 0 PU PRESTON PUBLICATIONS INC PI NILES PA 7800 MERRIMAC AVE PO BOX 48312, NILES, IL 60648 SN 0146-4760 J9 J ANAL TOXICOL JI J. Anal. Toxicol. PD SEP-OCT PY 1992 VL 16 IS 5 BP 337 EP 339 PG 3 WC Chemistry, Analytical; Toxicology SC Chemistry; Toxicology GA JN989 UT WOS:A1992JN98900014 PM 1294842 ER PT J AU WALKER, CW AF WALKER, CW TI HIGH-RATE DISCHARGE OF POLY 3-METHYLTHIOPHENE CATHODES IN INORGANIC ELECTROLYTES SO JOURNAL OF APPLIED ELECTROCHEMISTRY LA English DT Article ID POLY(3-METHYLTHIOPHENE); CELLS AB Lithium cells with thin film electrodes of poly 3-methylthiophene were discharged at high current densities in electrolytes containing either sulphur dioxide, thionyl chloride, or sulphuryl chloride. Highest capactiy was obtained with thionyl chloride electrolyte for current densities as high as 30 mA cm-2 (up to 600 W cm-3). Cells containing sulphur dioxide electrolyte were rechargeable, but constant current discharge performance was less than in either thionyl chloride or sulphuryl chloride. However, pulse discharge in sulphur dioxide permitted comparable power densities to be achieved, and reproducible results were obtained over many cycles. RP WALKER, CW (reprint author), USA,ELECTR TECHNOL & DEVICES LAB,LABCOM,FT MONMOUTH,NJ 07703, USA. NR 5 TC 1 Z9 1 U1 0 U2 1 PU CHAPMAN HALL LTD PI LONDON PA 2-6 BOUNDARY ROW, LONDON, ENGLAND SE1 8HN SN 0021-891X J9 J APPL ELECTROCHEM JI J. Appl. Electrochem. PD SEP PY 1992 VL 22 IS 9 BP 817 EP 820 DI 10.1007/BF01023723 PG 4 WC Electrochemistry SC Electrochemistry GA JM530 UT WOS:A1992JM53000006 ER PT J AU HOOVER, TA VODKIN, MH WILLIAMS, JC AF HOOVER, TA VODKIN, MH WILLIAMS, JC TI A COXIELLA-BURNETII REPEATED DNA ELEMENT RESEMBLING A BACTERIAL INSERTION-SEQUENCE SO JOURNAL OF BACTERIOLOGY LA English DT Article ID STREPTOMYCES-COELICOLOR A3(2); ESCHERICHIA-COLI; NUCLEOTIDE-SEQUENCE; SECONDARY-STRUCTURE; LEUCINE ZIPPER; MYCOBACTERIUM-TUBERCULOSIS; TRANSPOSABLE ELEMENT; REPETITIVE SEQUENCE; LYSOSOMAL RESPONSE; BINDING PROTEINS AB A DNA fragment located on the 3' side of the Coxiella burnetii htpAB operon was determined by Southern blotting to exist in approximately 19 copies in the Nine Mile I genome. The DNA sequences of this htpAB-associated repetitive element and two other independent copies were analyzed to determine the size and nature of the element. The three copies of the element were 1,450, 1,452, and 1,458 bp long, with less than 2% divergence among the three sequences. Several features characteristic of bacterial insertion sequences were discovered. These included a single significant open reading frame that would encode a 367-amino-acid polypeptide which was predicted to be highly basic, to have a DNA-binding helix-turn-helix motif, to have a leucine zipper motif, and to have homology to polypeptides found in several other bacterial insertion sequences. Identical 7-bp inverted repeats were found at the ends of all three copies of the element. However, duplications generated by many bacterial mobile elements in the recipient DNA during insertion events did not flank the inverted repeats of any of the three C. burnetii elements examined. A second pair of inverted repeats that flanked the open reading frame was also found in all three copies of the element. Most of the divergence among the three copies of the element occurred in the region between the two inverted repeat sequences in the 3' end of the element. Despite the sequence changes, all three copies of the element have retained significant dyad symmetry in this region. C1 PURDUE UNIV,SCH VET MED,DEPT VET PATHOBIOL,W LAFAYETTE,IN 47907. UNIV ILLINOIS,DEPT VET PATHOBIOL,URBANA,IL 61801. US FDA,CTR BIOL EVALUAT & RES,BETHESDA,MD 20892. RP HOOVER, TA (reprint author), USA,MED RES INST INFECT DIS,DIV BACTERIOL,FT DETRICK,FREDERICK,MD 21702, USA. NR 59 TC 79 Z9 80 U1 0 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0021-9193 J9 J BACTERIOL JI J. Bacteriol. PD SEP PY 1992 VL 174 IS 17 BP 5540 EP 5548 PG 9 WC Microbiology SC Microbiology GA JL431 UT WOS:A1992JL43100007 PM 1324903 ER PT J AU HOUNG, HSH NOON, KF OU, JT BARON, LS AF HOUNG, HSH NOON, KF OU, JT BARON, LS TI EXPRESSION OF VI-ANTIGEN IN ESCHERICHIA-COLI K-12 - CHARACTERIZATION OF VIAB FROM CITROBACTER-FREUNDII AND IDENTITY OF VIAA WITH RCSB SO JOURNAL OF BACTERIOLOGY LA English DT Article ID CAPSULAR POLYSACCHARIDE SYNTHESIS; SALMONELLA-PARATYPHI-C; STRAIN; TYPHI; GENES; DNA; CONSTRUCTION; REGULATOR; VACCINE; SYSTEM AB The Vi antigen in Salmonella typhi is stably expressed and may act to protect the strain against the defensive system of the host. Citrobacter freundii, not usually a common human pathogen, also expresses the Vi antigen but expresses it unstably, exhibiting a reversible transition between the Vi+ and Vi- states. Two widely separated chromosomal regions, ViaA and ViaB, are needed for Vi synthesis. Escherichia coli K-12 harboring a functional ViaB plasmid can also express Vi antigen, but the cloned ViaB sequence can only be stably maintained and expressed in recA hosts. Vi- derivatives arise either through IS1-like insertional events occurring in ViaB sequences or by chromosomal mutations at the ViaA region. P1vir mapping indicates that the ViaA mutations are located at min 47.75 on the E. coli chromosome. All the spontaneous viaA mutants isolated from E. coli and S. typhi were identified as rcsB mutants by complementation tests using plasmid pJB100. Introduction of rcsA=Tn10 into E. coli harboring functional ViaB sequences eliminates the expression of Vi antigen. These results indicate that Vi antigen synthesis is regulated by the same regulatory proteins involved in colanic acid synthesis in E. coli. C1 WALTER REED ARMY MED CTR,DEPT BACTERIAL IMMUNOL,WASHINGTON,DC 20307. CHANG GUNG MED COLL,DEPT MICROBIOL & IMMUNOL,TAOYUAN,TAIWAN. NR 34 TC 33 Z9 33 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0021-9193 J9 J BACTERIOL JI J. Bacteriol. PD SEP PY 1992 VL 174 IS 18 BP 5910 EP 5915 PG 6 WC Microbiology SC Microbiology GA JN264 UT WOS:A1992JN26400018 PM 1522067 ER PT J AU TOPPER, RQ TAWA, GJ TRUHLAR, DG AF TOPPER, RQ TAWA, GJ TRUHLAR, DG TI QUANTUM FREE-ENERGY CALCULATIONS - A 3-DIMENSIONAL TEST CASE SO JOURNAL OF CHEMICAL PHYSICS LA English DT Article AB An optimized integration scheme for calculating vibrational-rotational partition functions by the Fourier path-integral method, as presented in the previous paper [R. Q. Topper and D. G. Truhlar, J. Chem. Phys. 97, 3647 (1992)] is applied to a three-dimensional test case involving the coupled vibrational and rotational motions of a diatomic HCI molecule in Cartesian coordinates. Converged partition functions are calculated by the new Fourier path-integral Monte Carlo scheme and by standard variational methods, and the two sets of results are compared. We obtain good agreement (approximately 2%) between the two methods over a range of a factor of 20 in temperature. C1 UNIV MINNESOTA, ARMY HIGH PERFORMANCE COMP RES CTR, MINNEAPOLIS, MN 55455 USA. UNIV MINNESOTA, INST SUPERCOMP, DEPT CHEM, MINNEAPOLIS, MN 55455 USA. UNIV RHODE ISL, DEPT CHEM, KINGSTON, RI 02881 USA. RI Truhlar, Donald/G-7076-2015; Topper, Robert/P-9813-2016 OI Truhlar, Donald/0000-0002-7742-7294; Topper, Robert/0000-0001-6109-001X NR 19 TC 20 Z9 20 U1 0 U2 1 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-9606 J9 J CHEM PHYS JI J. Chem. Phys. PD SEP 1 PY 1992 VL 97 IS 5 BP 3668 EP 3673 DI 10.1063/1.462949 PG 6 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA JL372 UT WOS:A1992JL37200086 ER PT J AU KIM, KS ITABASHI, H GEMSKI, P SADOFF, J WARREN, RL CROSS, AS AF KIM, KS ITABASHI, H GEMSKI, P SADOFF, J WARREN, RL CROSS, AS TI THE K1-CAPSULE IS THE CRITICAL DETERMINANT IN THE DEVELOPMENT OF ESCHERICHIA-COLI MENINGITIS IN THE RAT SO JOURNAL OF CLINICAL INVESTIGATION LA English DT Article DE ESCHERICHIA-COLI; HEMATOGENOUS MENINGITIS; LIPOPOLYSACCHARIDE; K1-CAPSULAR POLYSACCHARIDE; PATHOGENESIS ID O-SIDE-CHAIN; NEISSERIA-MENINGITIDIS; NEONATAL MENINGITIS; MONOCLONAL-ANTIBODY; SERUM SENSITIVITY; BACTEREMIA; EFFICACY; RESISTANCE; ANTIGENS; CEFOTAXIME AB Although Escherichia coli strains possessing the K1 capsule are predominant among isolates from neonatal E coli meningitis and most of these K1 isolates are associated with a limited number of 0 lipopolysaccharide (LPS) types, the basis of this association of K1 and certain 0 antigens with neonatal E. coli meningitis is not clear. The present study examined in experimental E. coli bacteremia and meningitis in newborn and adult rats whether or not the K1 capsule and/or 0-LPS antigen are critical determinants in the development of meningitis. Rats received subcutaneously a K1 E. coli strain (018+K1+) or mutants lacking either the Kl capsule (018+K1-) or 0 side-chain (018-K1+). 12-24 h later, blood and cerebrospinal fluid (CSF) specimens were obtained for quantitative cultures. The isolation of E. coli from CSF was observed in both newborn and adult rats infected with K1+ strains regardless of LPS phenotype (018+ or 18-) who also developed a high degree of bacteremia (e.g., > 10(4) CFU/ml of blood). In contrast, none of the newborn and adult rats infected with 018+K1- and developing bacteremia of > 10(4) were found to have positive CSF cultures. These findings indicate that the presence of the K1 capsule and a high degree of bacteremia are key determinants in the development of E. coli meningitis, suggesting that there may be specific binding sites present in the brain which have an affinity for the Kl capsule and thus may be responsible for the entry of K1-encapsulated E. coli into the meninges. C1 UNIV SO CALIF,CHILDRENS HOSP LOS ANGELES,SCH MED,DEPT PEDIAT,LOS ANGELES,CA 90027. UNIV CALIF LOS ANGELES,HARBOR MED CTR,SCH MED,DEPT PATHOL,TORRANCE,CA 90509. WALTER REED ARMY MED CTR,DEPT MOLEC PATHOL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT BACTERIAL DIS,WASHINGTON,DC 20307. FU NINDS NIH HHS [R01-NS-26310] NR 47 TC 137 Z9 138 U1 0 U2 7 PU ROCKEFELLER UNIV PRESS PI NEW YORK PA 1114 FIRST AVE, 4TH FL, NEW YORK, NY 10021 SN 0021-9738 J9 J CLIN INVEST JI J. Clin. Invest. PD SEP PY 1992 VL 90 IS 3 BP 897 EP 905 DI 10.1172/JCI115965 PG 9 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA JN959 UT WOS:A1992JN95900028 PM 1326000 ER PT J AU WAAG, DM GALLOWAY, A SANDSTROM, G BOLT, CR ENGLAND, MJ NELSON, GO WILLIAMS, JC AF WAAG, DM GALLOWAY, A SANDSTROM, G BOLT, CR ENGLAND, MJ NELSON, GO WILLIAMS, JC TI CELL-MEDIATED AND HUMORAL IMMUNE-RESPONSES INDUCED BY SCARIFICATION VACCINATION OF HUMAN VOLUNTEERS WITH A NEW LOT OF THE LIVE VACCINE STRAIN OF FRANCISELLA-TULARENSIS SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID COXIELLA-BURNETII; PHASE-I; TULAREMIA; DIAGNOSIS; STIMULATION; ANTIGENS; PROTEINS; DISEASE; LVS AB Tularemia is a disease caused by the facultative intracellular bacterium Francisella tularensis. We evaluated a new lot of live F. tularensis vaccine for its immunogenicity in human volunteers. Scarification vaccination induced humoral and cell-mediated immune responses. Indications of a positive immune response after vaccination included an increase in specific antibody levels, which were measured by enzyme-linked immunosorbent and immunoblot assays, and the ability of peripheral blood lymphocytes to respond to whole F. tularensis bacteria as recall antigens. Vaccination caused a significant rise (P < 0.05) in immunoglobulin A (IgA), IgG, and IgM titers. Lymphocyte stimulation indices were significantly increased (P < 0.01) in vaccinees 14 days after vaccination. These data verify that this new lot of live F. tularensis vaccine is immunogenic. C1 USA,MED RES INST INFECT DIS,DIV MED,FREDERICK,MD 21702. USA,MED RES INST INFECT DIS,DIV BIOMETR & INFORMAT MANAGEMENT,FREDERICK,MD 21702. US FDA,CTR BIOL EVALUAT & RES,BETHESDA,MD 20892. NATL DEF RES ESTAB,DEPT MICROBIOL,S-90182 UMEA,SWEDEN. RP WAAG, DM (reprint author), USA,MED RES INST INFECT DIS,DEPT PATHOGENESIS & IMMUNOL,DIV BACTERIOL,FT DETRICK,FREDERICK,MD 21702, USA. NR 25 TC 25 Z9 27 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD SEP PY 1992 VL 30 IS 9 BP 2256 EP 2264 PG 9 WC Microbiology SC Microbiology GA JJ484 UT WOS:A1992JJ48400007 PM 1400988 ER PT J AU CHAICUMPA, W RUANGKUNAPORN, Y BURR, D CHONGSANGUAN, M ECHEVERRIA, P AF CHAICUMPA, W RUANGKUNAPORN, Y BURR, D CHONGSANGUAN, M ECHEVERRIA, P TI DIAGNOSIS OF TYPHOID-FEVER BY DETECTION OF SALMONELLA-TYPHI ANTIGEN IN URINE SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Note ID LINKED IMMUNOSORBENT-ASSAY; MONOCLONAL-ANTIBODY; RAPID DIAGNOSIS; SPECIMENS; BLOOD AB A monoclonal antibody specific for group D Salmonella antigen 9 was used in an indirect enzyme-linked immunosorbent assay (ELISA) for detecting the antigen in urine specimens collected from patients with clinical typhoid fever in Jakarta, Indonesia. The ELISA had a sensitivity of 95% in identifying patients in whom Salmonella typhi was isolated from hemocultures, 73% in patients in whom S. typhi was isolated from stool specimens, and 40% in patients in whom the organism was isolated from bone marrow cultures. Among patients in whom S. typhi was isolated from blood cultures, the ELISA had a sensitivity of 65% when a single urine specimen was examined and 95% when serially collected urine specimens were examined. A dot blot immunoassay performed on a nitrocellulose filter in parallel had a sensitivity of 85%, versus 83% for the plate ELISA in which S. typhi was isolated from blood, bone marrow, and/or stool specimens. Since S. typhi antigen is intermittently excreted in the urine of patients with typhoid fever, serially collected urine from patients with typhoid should be tested for antigen 9. C1 ARMED FORCES RES INST MED SCI,BANGKOK 10400,THAILAND. NAVAL MED RES UNIT 2,JAKARTA,INDONESIA. RP CHAICUMPA, W (reprint author), MAHIDOL UNIV,FAC TROP MED,DEPT MICROBIOL & IMMUNOL,BANGKOK 10700,THAILAND. NR 14 TC 28 Z9 28 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD SEP PY 1992 VL 30 IS 9 BP 2513 EP 2515 PG 3 WC Microbiology SC Microbiology GA JJ484 UT WOS:A1992JJ48400059 PM 1401030 ER PT J AU CARLSEN, DD ANDRE, T AF CARLSEN, DD ANDRE, T TI USE OF A MICROCOMPUTER SIMULATION AND CONCEPTUAL CHANGE TEXT TO OVERCOME STUDENT PRECONCEPTIONS ABOUT ELECTRIC-CIRCUITS SO JOURNAL OF COMPUTER-BASED INSTRUCTION LA English DT Article AB College students who had not taken college physics read either traditional text or conceptual change text (CCT) dealing with series electric circuits. The students either used a computer simulation of circuits before reading the text, while reading the text, or did not use the simulation. The purpose of the simulation was to have students test their preconceptions rather than simply being told about erroneous preconceptions. The results indicated that students who used the simulation and who used CCT learned more than students who did not, but that, contrary to expectations, use of the simulation did not enhance the effectiveness of CCT. The implications of these results for the design of computer-based instruction in science are discussed. C1 IOWA STATE UNIV SCI & TECHNOL,DEPT PSYCHOL,W112 LAGOMARCINO HALL,AMES,IA 50011. USA,SCH COMP SCI,FT GORDON,GA 30905. NR 17 TC 46 Z9 46 U1 0 U2 3 PU ADCIS INT HEADQUARTERS PI COLUMBUS PA 1601 WEST FIFTH AVE, SUITE 111, COLUMBUS, OH 43212 SN 0098-597X J9 J COMPUT-BASE INSTR PD FAL PY 1992 VL 19 IS 4 BP 105 EP 109 PG 5 WC Education & Educational Research SC Education & Educational Research GA KF415 UT WOS:A1992KF41500001 ER PT J AU SHLECHTER, TM BESSEMER, DW KOLOSH, KP AF SHLECHTER, TM BESSEMER, DW KOLOSH, KP TI COMPUTER-BASED SIMULATION SYSTEMS AND ROLE-PLAYING - AN EFFECTIVE COMBINATION FOR FOSTERING CONDITIONAL KNOWLEDGE SO JOURNAL OF COMPUTER-BASED INSTRUCTION LA English DT Article ID DESIGN AB This investigation examined the effectiveness of a computer-based training simulation system (SIMulation NETworking) combined with a program of role-playing activities for helping students to master the conditional knowledge needed for successful field performance. Field evaluations of 746 Armor Officer Basic (AOB) Course students who completed the AOB Course before SIMNET was implemented (Baseline Condition) were compared to the field evaluations of 607 students who received SIMNET training. Four hundred seventy of the latter students participated in the role-playing phase of this investigation. SIMNET's effectiveness was demonstrated for training military students to apply their newly acquired knowledge in the field exercises. Also, the positive transfer of SIMNET training was seemingly attributable to the students' engaging in appropriate role-playing activities during this training. The present findings have affirmed the hypothesized value of using computer-based simulation systems for training students to use higher order cognitive constructs. The effectiveness of such instructional systems is seemingly tied to providing students with realistic and safe ''learning-by-doing'' opportunities. C1 USA,RES CTR,FT KNOX,KY 40121. WESTERN KENTUCKY UNIV,BOWLING GREEN,KY 42101. NR 21 TC 12 Z9 12 U1 0 U2 2 PU ADCIS INT HEADQUARTERS PI COLUMBUS PA 1601 WEST FIFTH AVE, SUITE 111, COLUMBUS, OH 43212 SN 0098-597X J9 J COMPUT-BASE INSTR PD FAL PY 1992 VL 19 IS 4 BP 110 EP 114 PG 5 WC Education & Educational Research SC Education & Educational Research GA KF415 UT WOS:A1992KF41500002 ER PT J AU BEASLEY, RE LISTER, DB AF BEASLEY, RE LISTER, DB TI APPLICATION REPORT - USER ORIENTATION IN A HYPERTEXT GLOSSARY SO JOURNAL OF COMPUTER-BASED INSTRUCTION LA English DT Article AB This article describes the design of the XGRASS Glossary, an on-line, hypertext-based glossary system that contains definitions and explanations of the key terms and phrases associated with the U.S. Army Geographic Resources Analysis Support System (GRASS) and Geographic Information Systems (GISs) in general. It also discusses the rationale for adopting a hypertext environment and describes a unique. working solution to the problem of hypertext disorientation as employed in the XGRASS Glossary. This solution, called ''window stacking,'' combines elements of both the metaphor and the history list and provides users with a visual cue as to where they are within the Glossary and where they may go from there. Some initial user reactions to the Glossary's design are also reported. C1 USA,CONSTRUCT ENGN RES LABS,CHAMPAIGN,IL. RP BEASLEY, RE (reprint author), UNIV ILLINOIS,DEPT CURRICULUM & INSTRUCT,311 EDUC BLDG,1310 S 6TH ST,CHAMPAIGN,IL 61820, USA. NR 18 TC 2 Z9 2 U1 0 U2 0 PU ADCIS INT HEADQUARTERS PI COLUMBUS PA 1601 WEST FIFTH AVE, SUITE 111, COLUMBUS, OH 43212 SN 0098-597X J9 J COMPUT-BASE INSTR PD FAL PY 1992 VL 19 IS 4 BP 115 EP 118 PG 4 WC Education & Educational Research SC Education & Educational Research GA KF415 UT WOS:A1992KF41500003 ER PT J AU BURMAN, KD DJUH, YY NICHOLSON, D RHOOMS, P WARTOFSKY, L FEIN, HG USALA, SJ HAO, EH BRADLEY, WEC BERARD, J SMALLRIDGE, RC AF BURMAN, KD DJUH, YY NICHOLSON, D RHOOMS, P WARTOFSKY, L FEIN, HG USALA, SJ HAO, EH BRADLEY, WEC BERARD, J SMALLRIDGE, RC TI GENERALIZED THYROID-HORMONE RESISTANCE - IDENTIFICATION OF AN ARGININE TO CYSTINE MUTATION IN CODON-315 OF THE C-ERB A-BETA THYROID-HORMONE RECEPTOR SO JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION LA English DT Article DE GENERALIZED RESISTANCE; MUTATION; THYROID HORMONE RECEPTOR ID CULTURED SKIN FIBROBLASTS; BINDING; GENE; AFFINITY; KINDREDS; DOMAIN AB The present report studies a large kindred (WR) with generalized thyroid hormone resistance that has varying degrees of neuropsychological dysfunction, hyperactivity, poor attention span, decreased IQ and/or abnormalities in spatial perception. In this kindred, there has been found tight linkage of the syndrome with the c-erb A beta gene. The present study was performed to identify the presence of a possible gene mutation as a cause for this syndrome. DNA from peripheral leukocytes was isolated from 15 unaffected and 8 affected individuals from the kindred. Primers encompassing exons 9 (nucleotides 1171-1429) and 10 (nucleotides 1430-1698) were synthesized and used in PCR reactions to amplify these exons. Direct sequencing revealed a consistent substitution in each affected subject, but in none of the unaffected individuals, of a C to T change in one allele from nucleotide 1243, resulting in an arg to cys change in codon 315. The mutant and wild-type human beta 1 receptors were prepared and their translated proteins were analyzed for T3 binding. The WR T3 receptor from affected patients had reduced T3 binding affinity, with values approximately 2.5 x 10(10) M-1 compared to about 5 x 10(10) M-1 in normals. In summary, we have: i) identified a consistent and reproducible mutation of a C to T change in nucleotide 1243 in each of the affected but in none of the unaffected individuals of a large well characterized kindred with generalized thyroid hormone resistance, and ii) noted that the WR allele causes an approximate 50% decrease in the T3 binding affinity. Further studies analyzing the mechanism by which a single point mutation in one allele results in the biochemical and clinical manifestations of generalized thyroid hormone resistance are warranted. C1 WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,DEPT MED,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,DEPT CLIN PHYSIOL,WASHINGTON,DC 20307. E CAROLINA UNIV,SCH MED,DEPT MED,GREENVILLE,NC 27834. INST CANC MONTREAL,MONTREAL,QUEBEC,CANADA. RP BURMAN, KD (reprint author), WALTER REED ARMY MED CTR,DEPT MED,KYLE METAB UNIT,ENDOCRINE METAB SERV,WASHINGTON,DC 20307, USA. FU NIDDK NIH HHS [DK 42807] NR 26 TC 15 Z9 15 U1 0 U2 0 PU EDITRICE KURTIS S R L PI MILANO PA VIA LUIGI ZOJA, 30-20153 MILANO, ITALY SN 0391-4097 J9 J ENDOCRINOL INVEST JI J. Endocrinol. Invest. PD SEP PY 1992 VL 15 IS 8 BP 573 EP 579 PG 7 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA JT356 UT WOS:A1992JT35600004 PM 1358935 ER PT J AU HILTNER, RS KULILD, JC WELLER, RN AF HILTNER, RS KULILD, JC WELLER, RN TI EFFECT OF MECHANICAL VERSUS THERMAL REMOVAL OF GUTTA-PERCHA ON THE QUALITY OF THE APICAL SEAL FOLLOWING POST SPACE PREPARATION SO JOURNAL OF ENDODONTICS LA English DT Article ID TEETH AB The objective of this study was to compare the effects of a flame-heated endodontic plugger, an electrically-heated endodontic spreader, Peeso reamers, and GPX burs on the apical seal when gutta-percha was removed from the root canal for post space preparation. Eighty-nine human canines were instrumented and obturated with gutta-percha and sealer to a standardized working length of 15 mm. An 11-mm segment of gutta-percha was removed from the roots in each of the four experimental groups of 20 teeth to simulate post space preparation. The teeth were immersed in India ink for 7 days and rendered transparent. The extent of linear dye leakage was measured with a stereomicroscope. There was no statistically significant difference in linear dye leakage among any of the experimental groups when 4 mm of gutta-percha remained. C1 USA,DENT ACT,FT STEWART,GA. NR 15 TC 13 Z9 14 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0099-2399 J9 J ENDODONT JI J. Endod. PD SEP PY 1992 VL 18 IS 9 BP 451 EP 454 DI 10.1016/S0099-2399(06)80848-4 PG 4 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA KG638 UT WOS:A1992KG63800008 PM 9796515 ER PT J AU THACKSTON, EL PALERMO, MR AF THACKSTON, EL PALERMO, MR TI PREDICTING EFFLUENT PCBS FROM SUPERFUND SITE DREDGED MATERIAL SO JOURNAL OF ENVIRONMENTAL ENGINEERING-ASCE LA English DT Article AB The Corps of Engineers and EPA conducted a feasibility study of using dredges to remove PCBs from the highly contaminated sediments of the New Bedford, Mass., harbor, a Superfund site. Three types of dredges were tested. Also, a confined disposal facility (CDF) was constructed to test the feasibility of onshore containment of the dredged material. Laboratory settling tests and modified elutriate tests were conducted prior to dredging to predict the release of PCBs in the effluent. Comparisons and predictions with field measurements showed that the prediction method was valid and useful for PCBs. The average concentration of dissolved PCB of 4.8 mug/L was close to the prediction of 7.5 mug/L. The average total concentration of 28 mug/L was less than the predicted value of 65 mug/L, because the average effluent suspended solids (SS) of 67 mg/L was less than the predicted 120 mg/L, due to dredge operating problems. Other data showed that dredging is a feasible remediation method. C1 USA,ENGR WATERWAYS EXPT STN,ENVIR LAB,VICKSBURG,MS 39180. RP THACKSTON, EL (reprint author), VANDERBILT UNIV,DEPT CIVIL & ENVIRONM ENGN,NASHVILLE,TN 37235, USA. NR 9 TC 1 Z9 1 U1 1 U2 2 PU ASCE-AMER SOC CIVIL ENGINEERS PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-9372 J9 J ENVIRON ENG-ASCE JI J. Environ. Eng.-ASCE PD SEP-OCT PY 1992 VL 118 IS 5 BP 657 EP 665 DI 10.1061/(ASCE)0733-9372(1992)118:5(657) PG 9 WC Engineering, Environmental; Engineering, Civil; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA JP935 UT WOS:A1992JP93500002 ER PT J AU HALLBERG, LM CHINACHOTI, P AF HALLBERG, LM CHINACHOTI, P TI DYNAMIC MECHANICAL ANALYSIS FOR GLASS TRANSITIONS IN LONG SHELF-LIFE BREAD SO JOURNAL OF FOOD SCIENCE LA English DT Article DE DYNAMIC MECHANICAL ANALYSIS; GLASS TRANSITION; STORAGE; BREAD ID STARCH AB Dynamic Mechanical Analysis (DMA) showed three thermal transitions in meal, ready-to-eat (MRE) bread, resulting in various degrees of change in the viscoelastic property. The moisture-dependent transition at an extremely low temperature (-90-degrees-C to -50-degrees-C) was due to humectants added, while that at a higher temperature T1 was possibly due to ice melting and the polymer components. T1 increased from almost-equal-to -10-degrees-C at 29% moisture to almost-equal-to 150-degrees-C as moisture decreased to 2%. This correlated with hardening of the sample. A moisture independent transition at almost-equal-to 10-15-degrees-C by DMA was identified as a melting process of lipids (shortening). During storage, the magnitude of tan delta peak decreased but its peak temperature did not change. No evidence of any network could be observed by DMA throughout 3 yr storage. C1 UNIV MASSACHUSETTS,DEPT FOOD SCI,AMHERST,MA 01003. RP HALLBERG, LM (reprint author), USA,NATICK RD&E CTR,NATICK,MA 01760, USA. RI Chinachoti, Pavinee/C-8892-2009 NR 22 TC 46 Z9 49 U1 2 U2 11 PU INST FOOD TECHNOLOGISTS PI CHICAGO PA SUITE 300 221 N LASALLE ST, CHICAGO, IL 60601-1291 SN 0022-1147 J9 J FOOD SCI JI J. Food Sci. PD SEP-OCT PY 1992 VL 57 IS 5 BP 1201 EP & DI 10.1111/j.1365-2621.1992.tb11299.x PG 0 WC Food Science & Technology SC Food Science & Technology GA JR781 UT WOS:A1992JR78100049 ER PT J AU BARRETT, AH PELEG, M AF BARRETT, AH PELEG, M TI EXTRUDATE CELL STRUCTURE-TEXTURE RELATIONSHIPS SO JOURNAL OF FOOD SCIENCE LA English DT Article DE CORN; EXTRUDATES; CELL STRUCTURE; TEXTURE; GLUTEN; RICE FLOUR ID TIME EXTRUSION COOKING; WHEAT-STARCH; CORN STARCH; PROTEIN; FLOUR AB Com-based extrudates that ranged widely in mean cell size and density were produced by varying extrusion moisture and RPM and also by the addition of rice flour, citric acid, tricalcium phosphate, sodium bicarbonate, and gluten. Cell sizes were measured using an Olympus image analysis system and mechanical properties, including breaking stress and plateau stress values achieved during compression, were measured using an Instron. Breaking and plateau stresses were negatively dependent on mean cell size and positively dependent on density in pure corn samples but the form of the relationship was altered by the presence of additives in the extrudates. C1 UNIV MASSACHUSETTS,DEPT FOOD SCI,AMHERST,MA 01003. RP BARRETT, AH (reprint author), USA,NATICK RD&E CTR,FOOD ENGN DIRECTORATE,NATICK,MA 01760, USA. NR 17 TC 62 Z9 63 U1 0 U2 9 PU INST FOOD TECHNOLOGISTS PI CHICAGO PA SUITE 300 221 N LASALLE ST, CHICAGO, IL 60601-1291 SN 0022-1147 J9 J FOOD SCI JI J. Food Sci. PD SEP-OCT PY 1992 VL 57 IS 5 BP 1253 EP 1257 DI 10.1111/j.1365-2621.1992.tb11311.x PG 5 WC Food Science & Technology SC Food Science & Technology GA JR781 UT WOS:A1992JR78100061 ER PT J AU WITTICH, AC AF WITTICH, AC TI LARGE PELVIC MASS OF NONGYNECOLOGIC ORIGIN - CASE-REPORT SO JOURNAL OF GYNECOLOGIC SURGERY LA English DT Article ID MESENTERIC CYSTS; RETROPERITONEAL AB Diagnosis of a pelvic mass during gynecologic examination usually indicates pathology of the uterus, tubes, or ovaries or a combination of these generative organs. Before surgical evaluation, a preoperative evaluation includes radiologic studies, tumor markers, and complete hematologic and urologic analysis. If diagnostic evaluation demonstrates nongynecologic pathology, the patient should be referred to a general surgeon or urology colleage, according to the source of pathology. Findings of uterine or ovarian pathology require surgical evaluation, and if malignancy is suspected, a gynecologic oncologist should be involved with the surgery. This report presents a patient with the operative finding of a tumor of nongynecologic origin. The preoperative workup, the operative findings, and a classification of mesenteric cysts are discussed. RP WITTICH, AC (reprint author), TRIPLER ARMY MED CTR,DEPT OB GYN,HONOLULU,HI 96859, USA. NR 14 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 1042-4067 J9 J GYNECOL SURG JI J. Gynecol. Surg. PD FAL PY 1992 VL 8 IS 3 BP 191 EP 193 DI 10.1089/gyn.1992.8.191 PG 3 WC Obstetrics & Gynecology; Surgery SC Obstetrics & Gynecology; Surgery GA KD884 UT WOS:A1992KD88400012 ER PT J AU QIAN, CG LIU, CT PETERS, CJ AF QIAN, CG LIU, CT PETERS, CJ TI INCREASED PLATELET-ACTIVATING-FACTOR (PAF) CONCENTRATIONS IN HEARTS AND LUNGS OF PICHINDE VIRUS-INFECTED GUINEA-PIGS SO JOURNAL OF LIPID MEDIATORS LA English DT Article DE PAF; TISSUE CONCENTRATIONS; PICHINDE VIRAL INFECTION ID RECEPTOR ANTAGONIST; RAT; IDENTIFICATION; INVOLVEMENT; RELEASE AB Platelet-activating factor (PAF) has been implicated as a cause of cardiopulmonary disturbances in certain diseases. In the present study, concentrations of PAF in hearts, lungs, whole blood, and other organs of control and Pichinde virus-infected guinea pigs on post-inoculation days (PID) 10 and 14 were measured by radioimmunoassay. Results were further confirmed by bioassay after separation and purification with thin-layer chromatography. PAF concentration in the hearts and lungs of virus-infected animals increased significantly on PID 10 and 14, as compared with control levels. PAF level in the blood of infected guinea pigs also significantly increased on PID 14. There was little change of PAF levels in liver and kidney after viral inoculation. Increased PAF concentrations in both hearts and lungs of infected strain 13 guinea pigs suggest that this lipid mediator may play an important role in the development of cardiopulmonary disturbances. C1 USA, MED RES INST INFECT DIS DEPT CLIN & EXPTL PHYSIOL, DIV DIS ASSESSMENT, FREDERICK, MD 21702 USA. NR 30 TC 6 Z9 6 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0921-8319 J9 J LIPID MEDIATOR JI J. Lipid Mediat. PD SEP PY 1992 VL 5 IS 3 BP 261 EP 270 PG 10 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA JU236 UT WOS:A1992JU23600006 PM 1334721 ER PT J AU DURDEN, LA AF DURDEN, LA TI PARASITIC ARTHROPODS OF SYMPATRIC MEADOW VOLES AND WHITE-FOOTED MICE AT FORT DETRICK, MARYLAND SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE ARTHROPODA; PARASITES; SMALL MAMMALS; MARYLAND ID DERMACENTOR-VARIABILIS ACARI; PEROMYSCUS-LEUCOPUS; POPULATION-DYNAMICS; CENTRAL TENNESSEE; LYME-DISEASE; IXODIDAE; MAMMALS; HOST; INSECTA; FLEAS AB Twelve species of parasitic arthropods (one sucking louse, two fleas, one tick, and eight mites) were recovered from 51 meadow voles, Microtus pennsylvanicus (Ord); whereas nine species (one sucking louse, one bot, three fleas, one tick, and three mites) were collected from 48 white-footed mice, Peromyscus leucopus (Rafinesque), live-trapped on the grounds of Fort Detrick, Frederick County, Md., during 1990 and 1991. The most commonly collected arthropods from M. pennsylvanicus were the fur mite, Listrophorus mexicanus Fain (almost-equal-to 2,720 specimens); the tropical rat mite, Ornithonyssus bacoti (Hirst) (987); the laelapid mites, Laelaps kochi Oudemans (733) and Androlaelaps fahrenholzi (Berlese) (322); the sucking louse, Hoplopleura acanthopus (Burmeister) (121); the tick, Dermacentor variabilis (Say) (47); and the chigger mite, Neotrombicula whartoni (Ewing) (45). Arthropod densities were lower on P. leucopus, from which the most frequently recorded species were the sucking louse, Hoplopleura hesperomydis (Osborn) (98 specimens); the fleas, Epitedia wenmanni (Rothschild) (85) and Orchopeas leucopus (Baker) (61); and the mite, A. fahrenholzi (83). Although six species of arthropods parasitized both species of rodents, only two of these, A. fahrenholzi and D. variabilis, were relatively common on both hosts. Therefore, although the habitats of both host species partially overlap, their associated parasitic arthropods remain principally host specific. The potential significance of these findings with respect to vector-borne disease transmission is discussed. C1 USA,MED RES INST INFECT DIS,DEPT ARBOVIRAL ENTOMOL,DIV VIROL,FREDERICK,MD 21702. NR 32 TC 8 Z9 10 U1 1 U2 3 PU ENTOMOL SOC AMER PI LANHAM PA 9301 ANNAPOLIS RD, LANHAM, MD 20706 SN 0022-2585 J9 J MED ENTOMOL JI J. Med. Entomol. PD SEP PY 1992 VL 29 IS 5 BP 761 EP 766 PG 6 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA JN291 UT WOS:A1992JN29100006 PM 1404254 ER PT J AU DICKSON, DL TURELL, MJ AF DICKSON, DL TURELL, MJ TI REPLICATION AND TISSUE TROPISMS OF CRIMEAN-CONGO HEMORRHAGIC-FEVER VIRUS IN EXPERIMENTALLY INFECTED ADULT HYALOMMA-TRUNCATUM (ACARI, IXODIDAE) SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE INSECTA; HYALOMMA-TRUNCATUM; CRIMEAN-CONGO HEMORRHAGIC FEVER VIRUS; REPLICATION ID DUGBE VIRUS; RUFIPES KOCH; TICK; NAIROVIRUS; BUNYAVIRIDAE; TRANSMISSION; AFRICA; GENUS AB Adult Hyalomma truncatum Koch ticks were inoculated intracoelomically with Crimean-Congo hemorrhagic fever (CCHF) virus to examine tissue tropisms of this virus in ticks. Virus was recovered from all 185 ticks examined between 2 and 42 d after inoculation with CCHF virus. Titers or virus recovered from unfed male and female ticks were essentially the same (means, 10(2.4) and 10(2.5) plaque-forming units [PFU] per tick, respectively). Infection rates and titers recovered per gland for both salivary glands and reproductive tissues (ovaries and testes) were positively associated with blood feeding; average titers were 10-fold greater in organs from fed compared with those from unfed individuals. In contrast, neither the tick's sex nor feeding status (unfed or engorged) affected the titer of virus recovered from hemolymph (mean, 10(1.6) PFU/mu-l). Although virus was recovered from Malpighian tubules, midgut, muscle, and nervous tissues from nearly all of the ticks tested, viral titers were consistently low. The increase in viral titer associated with blood feeding by ticks appeared to be due primarily to proliferation of tissue (e.g., salivary gland and reproductive tissues), rather than to increased replication in tissue already present. RP DICKSON, DL (reprint author), USA,MED RES INST INFECT DIS,DIV VIROL,FREDERICK,MD 21702, USA. NR 15 TC 12 Z9 14 U1 0 U2 1 PU ENTOMOL SOC AMER PI LANHAM PA 9301 ANNAPOLIS RD, LANHAM, MD 20706 SN 0022-2585 J9 J MED ENTOMOL JI J. Med. Entomol. PD SEP PY 1992 VL 29 IS 5 BP 767 EP 773 PG 7 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA JN291 UT WOS:A1992JN29100007 PM 1404255 ER PT J AU TURELL, MJ AF TURELL, MJ TI VIRUS-DEPENDENT MORTALITY IN RIFT-VALLEY FEVER, EASTERN EQUINE ENCEPHALOMYELITIS, AND CHIKUNGUNYA VIRUS-INOCULATED MOSQUITO (DIPTERA, CULICIDAE) LARVAE SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE INSECTA; CULICIDAE; INOCULATION; ARBOVIRAL; MORTALITY ID CALIFORNIA ENCEPHALITIS-VIRUS; TRANS-OVARIAL TRANSMISSION; CULEX-PIPIENS; AEDES-DORSALIS; VECTOR; INFECTION AB The effect of inoculation of mosquito larvae with Rift Valley fever (RVF) virus on survival to the adult stage was evaluated in Aedes aegypti (L.), Ae. fowleri (Charmoy), Ae. mcintoshi Huang, Ae. taeniorhynchus (Wiedemann), Ae. triseriatus (Say), Eretmapodites quinquevittatus Theobald, Anopheles albimanus Wiedemann, and Culex pipiens L. Pupation rates were similar for RVF virus-inoculated and diluent-inoculated larvae of all mosquito species tested except Cx. pipiens. However, with the exception of An. albimanus and Ae. triseriatus, virtually all pupae derived from RVF vims-inoculated larvae failed to emerge successfully as adults. In contrast, both pupation and emergence rates were similar for diluent-inoculated and either La Crosse or St. Louis encephalitis virus-inoculated larvae of Ae. taeniorhynchus. There was also poor survival to the adult stage of Ae. taeniorhynchus inoculated with either eastern equine encephalomyelitis (EEE) or chikungunya (CHIK) virus. The high mortality rates observed under laboratory conditions of pupae derived from larvae inoculated with either RVF, EEE, or CHIK virus may be responsible for the lack of laboratory confirmation of vertical transmission of these viruses. RP TURELL, MJ (reprint author), USA,MED RES INST INFECT DIS,DIV DIS ASSESSMENT,DEPT EPIDEMIOL,FREDERICK,MD 21702, USA. NR 11 TC 4 Z9 4 U1 4 U2 4 PU ENTOMOL SOC AMER PI LANHAM PA 9301 ANNAPOLIS RD, LANHAM, MD 20706 SN 0022-2585 J9 J MED ENTOMOL JI J. Med. Entomol. PD SEP PY 1992 VL 29 IS 5 BP 792 EP 795 PG 4 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA JN291 UT WOS:A1992JN29100010 PM 1357176 ER PT J AU TURELL, MJ BEAMAN, JR AF TURELL, MJ BEAMAN, JR TI EXPERIMENTAL TRANSMISSION OF VENEZUELAN EQUINE ENCEPHALOMYELITIS VIRUS BY A STRAIN OF AEDES-ALBOPICTUS (DIPTERA, CULICIDAE) FROM NEW-ORLEANS, LOUISIANA SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE INSECTA; AEDES-ALBOPICTUS; VECTOR COMPETENCE; VENEZUELAN EQUINE ENCEPHALOMYELITIS VIRUS ID VALLEY FEVER VIRUS; ENCEPHALITIS-VIRUS; UNITED-STATES; CULEX-PIPIENS; CDNA CLONE; AMERICA AB Experimental studies were undertaken to ascertain the vector competence of a strain of Aedes albopictus (Skuse) collected in New Orleans, LA, (Gentilly strain) for an epizootic (Trinidad donkey) strain of Venezuelan equine encephalomyelitis (VEE) virus. This strain of Ae. albopictus was significantly more susceptible to infection with VEE virus than were any of the four strains tested previously, including two from North America and two from South America. Likewise, dissemination (148 of 180) (82%) and transmission (40 of 88) (45%) rates were significantly higher in the Gentilly strain than in any of the strains previously tested. Analysis of the results of the present study along with those of a previous study with a second alphavirus, chikungunya (CHIK) virus, indicated that, although all three strains of Ae. albopictus tested were more susceptible to VEE virus than to CHIK virus, susceptibility to infection and dissemination with one alphavirus appeared to be directly related to susceptibility to infection and dissemination with the other virus and may indicate shared receptor sites for these two alphaviruses in Ae. albopictus. RP TURELL, MJ (reprint author), USA,MED RES INST INFECT DIS,DIV DIS ASSESSMENT,FREDERICK,MD 21702, USA. NR 18 TC 12 Z9 12 U1 0 U2 0 PU ENTOMOL SOC AMER PI LANHAM PA 9301 ANNAPOLIS RD, LANHAM, MD 20706 SN 0022-2585 J9 J MED ENTOMOL JI J. Med. Entomol. PD SEP PY 1992 VL 29 IS 5 BP 802 EP 805 PG 4 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA JN291 UT WOS:A1992JN29100012 PM 1404258 ER PT J AU LINTHICUM, KJ GORDON, SW MONATH, TP AF LINTHICUM, KJ GORDON, SW MONATH, TP TI COMPARATIVE INFECTIONS OF EPIZOOTIC AND ENZOOTIC STRAINS OF VENEZUELAN EQUINE ENCEPHALOMYELITIS VIRUS IN AMBLYOMMA-CAJENNENSE (ACARI, IXODIDAE) SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE ARACHNIDA; AMBLYOMMA-CAJENNENSE; VENEZUELAN EQUINE ENCEPHALOMYELITIS VIRUS; VIRUS STRAINS ID MELANOCONION TAENIOPUS MOSQUITOS; ENCEPHALITIS-VIRUS; TRANSMISSION; THRESHOLD; HOST AB To compare the potential for an enzootic or an epizootic strain of Venezuelan equine encephalomyelitis (VEE) virus to infect Amblyomma cajennense (F.), larval ticks were fed on guinea pigs (strain 13) inoculated with an enzootic viral strain of variant I-E (68U201) or on guinea pigs inoculated with an epizootic strain of variant I-A (Trinidad donkey). Peak viremias were 10(5.2) plaque-forming units (PFU)/ml and 10(7.3) PFU/ml in guinea pigs infected with enzootic and epizootic viral strains, respectively. Ticks feeding on enzootic- and epizootic-infected hosts had viral titers of 10(2.5) and 10(3.9) PFU per tick, respectively, at drop-off. Although epizootic virus was recovered from 98% (127 of 130) of larval ticks up to 16 d after drop-off, enzootic virus was recovered from 95% (19 of 20) at drop-off (mean titer, 10(2.5) PFU per tick), with recovery rates declining rapidly to 2 of 10 (mean titer, 10(1.4) PFU per tick) by 16 d after drop-off. Transstadially transmitted epizootic virus was found in 0.4% (12 of 2,950) of unfed nymphs (mean titer, 10(2.8) PFU per tick) 63 d after drop-off, 1% (5 of 521) fed nymphs 69 d after drop-off, and 1% (4 of 400) of unfed adults (mean titer, 10(3.6) PFU per tick) 106 d after drop-off. No enzootic virus was recovered from 4,600 unfed nymphs tested 63 d after drop-off. RP LINTHICUM, KJ (reprint author), USA,MED RES INST INFECT DIS,DIV VIROL,DEPT ARBOVIRAL ENTOMOL,FREDERICK,MD 21702, USA. RI Gordon, Scott/B-8875-2011 NR 15 TC 3 Z9 3 U1 0 U2 0 PU ENTOMOL SOC AMER PI LANHAM PA 9301 ANNAPOLIS RD, LANHAM, MD 20706 SN 0022-2585 J9 J MED ENTOMOL JI J. Med. Entomol. PD SEP PY 1992 VL 29 IS 5 BP 827 EP 831 PG 5 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA JN291 UT WOS:A1992JN29100016 PM 1404262 ER PT J AU WIRTZ, RA SATTABONGKOT, J HALL, T BURKOT, TR ROSENBERG, R AF WIRTZ, RA SATTABONGKOT, J HALL, T BURKOT, TR ROSENBERG, R TI DEVELOPMENT AND EVALUATION OF AN ENZYME-LINKED-IMMUNOSORBENT-ASSAY FOR PLASMODIUM-VIVAX-VK247 SPOROZOITES SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE PLASMODIUM-VIVAX; CIRCUMSPOROZOITE PROTEIN DETECTION; ELISA ID PLASMODIUM-VIVAX; CIRCUMSPOROZOITE PROTEIN; ANTIBODY AB An enzyme-linked immunosorbent assay (ELISA) for the Plasmodium vivax-VK247 (variant) circumsporozoite (CS) protein was developed and evaluated using sporozoites produced by feeding mosquitoes on Thai patients with parasitologically confirmed P. vivax infections. The ELISA had a detection threshold of fewer than 50 sporozoites. Using this assay in conjunction with an ELISA for the VK210 polymorph, nearly 16% of the 235 P. vivax cases produced sporozoites positive only for the variant; 69% produced sporozoites positive only in the VK210 assay; and 15% were positive in both assays, indicating mixed infections. Twelve cases (5%) produced sporozoites negative in one assay and with unexpectedly low activity in the other ELISA, indicating the possibility of other CS protein polymorphs. C1 WALTER REED ARMY MED CTR,DEPT IMMUNOL,DIV COMMUNICABLE DIS & IMMUNOL,WASHINGTON,DC 20307. RP WIRTZ, RA (reprint author), WALTER REED ARMY MED CTR,DEPT ENTOMOL,DIV COMMUNICABLE DIS & IMMUNOL,WASHINGTON,DC 20307, USA. RI Burkot, Thomas/C-6838-2013 NR 10 TC 82 Z9 83 U1 0 U2 1 PU ENTOMOL SOC AMER PI LANHAM PA 9301 ANNAPOLIS RD, LANHAM, MD 20706 SN 0022-2585 J9 J MED ENTOMOL JI J. Med. Entomol. PD SEP PY 1992 VL 29 IS 5 BP 854 EP 857 PG 4 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA JN291 UT WOS:A1992JN29100020 PM 1404266 ER PT J AU WIGNALL, FS HYAMS, KC PHILLIPS, IA ESCAMILLA, J TEJADA, A LI, O LOPEZ, F CHAUCA, G SANCHEZ, S ROBERTS, CR AF WIGNALL, FS HYAMS, KC PHILLIPS, IA ESCAMILLA, J TEJADA, A LI, O LOPEZ, F CHAUCA, G SANCHEZ, S ROBERTS, CR TI SEXUAL TRANSMISSION OF HUMAN T-LYMPHOTROPIC VIRUS TYPE-I IN PERUVIAN PROSTITUTES SO JOURNAL OF MEDICAL VIROLOGY LA English DT Article DE RETROVIRAL INFECTIONS; SEXUALLY TRANSMITTED DISEASE; PERU; HTLV-I ID CELL LEUKEMIA-VIRUS; TROPICAL SPASTIC PARAPARESIS; HUMAN IMMUNODEFICIENCY VIRUS; HTLV-I; FEMALE PROSTITUTES; ANTIBODIES; INFECTION; RISK; SEROPREVALENCE; PREVALENCE AB The epidemiology of HTLV-1 infection in female prostitutes was studied in a survey of 395 prostitutes from Callao, Peru (the port city of Lima), 72 prostitutes from Iquitos, Peru (another port city on the Amazon River), and 510 prenatal clinic patients from Lima. Prostitutes reported a mean of 8.8 years (range, 1-39 years) of active prostitution and a mean of 205 sexual contacts during the month prior to the study. The percentage of prostitutes with HTLV-I antibody (21.8%) was significantly higher than patients attending a prenatal clinic (3.1%; P < .0001). The prevalence of HTLV-I antibody increased steadily with age in prostitutes, but no age trend was noted in prenatal patients. By multiple logistic regression analysis, an independent association was found between HTLV-I seropositivity and a history of prostitution in Callao, age, and positive syphilis serology when all 977 study subjects were evaluated. When prostitutes alone were analyzed, the number of years of exposure as a practicing prostitute was associated with HTLV-I seropositivity after controlling for age. These data indicate a greatly increased risk of HTLV-I infection in prostitutes in Callao, Peru, and suggest an association between sexual activity and HTLV-I transmission. C1 USN,MED RES INST DETACHMENT,APO,MIAMI,FL. USN,MED RES INST,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,SILVER SPRING,MD. SERV VENEREAS CALLAO,LIMA,PERU. UNIV NACL MAYOR SAN MARCOS,LIMA,PERU. MINIST SALUD,HOSP MATERNO INFANTIL SAN BARTOLOME,LIMA,PERU. NR 25 TC 29 Z9 31 U1 0 U2 1 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0146-6615 J9 J MED VIROL JI J. Med. Virol. PD SEP PY 1992 VL 38 IS 1 BP 44 EP 48 DI 10.1002/jmv.1890380110 PG 5 WC Virology SC Virology GA JK555 UT WOS:A1992JK55500009 PM 1402830 ER PT J AU PERKINS, SJ NEWHOUSE, RF BACH, DE AF PERKINS, SJ NEWHOUSE, RF BACH, DE TI A MODIFIED BOLEY GAUGE FOR ACCURATE MEASUREMENT DURING MAXILLARY OSTEOTOMIES SO JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY LA English DT Note C1 TRIPLER ARMY MED CTR,DEPT ORAL & MAXILLOFACIAL SURG,HONOLULU,HI 96859. RP PERKINS, SJ (reprint author), USA DENTAC,ORAL & MAXILLOFACIAL SURG,FT SILL,OK 73503, USA. NR 1 TC 12 Z9 12 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0278-2391 J9 J ORAL MAXIL SURG JI J. Oral Maxillofac. Surg. PD SEP PY 1992 VL 50 IS 9 BP 1018 EP 1019 DI 10.1016/0278-2391(92)90067-A PG 2 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA JL569 UT WOS:A1992JL56900022 PM 1506961 ER PT J AU WEISMAN, LE STOLL, BJ CRUESS, DF HALL, RT MERENSTEIN, GB HEMMING, VG FISCHER, GW AF WEISMAN, LE STOLL, BJ CRUESS, DF HALL, RT MERENSTEIN, GB HEMMING, VG FISCHER, GW TI EARLY-ONSET GROUP-B STREPTOCOCCAL SEPSIS - A CURRENT ASSESSMENT SO JOURNAL OF PEDIATRICS LA English DT Article ID SELECTIVE INTRAPARTUM CHEMOPROPHYLAXIS; BIRTH-WEIGHT; RISK-FACTORS; DISEASE; INFECTIONS; INFANTS; SEPTICEMIA; EXPERIENCE; PENICILLIN; SPECTRUM AB Group B streptococcus (GBS) is a common cause of early-onset sepsis in neonates. The most recent reviews describing incidence, diagnosis, treatment, and outcome evaluated data on patients from the early 1980s. To obtain current information about this disease, we retrospectively evaluated data on neonates with GBS early-onset sepsis from nine hospitals in the United States between Jan. 1, 1987, and Dec. 31, 1989. There were 245 infants with GBS bacteremia identified among 61,809 live births, resulting in an incidence of 0.32%. Ninety-six infants (39%) were preterm (<38 weeks of gestational age). Maternal risk factors for infected preterm and term infants were similar. Antibiotics were administered during parturition in 10% of infants with bacteremia. Mothers of preterm infants received antibiotics up to 48 hours before delivery; mothers of term infants received antibiotics less than 4 hours before delivery. All preterm infants with bacteremia had symptoms; 22% of term infants with bacteremia hod no symptoms. Group B streptococcal meningitis. was confirmed in 6.3% of infants. Although 86% survived, GBS sepsis increased the birth weight-specific mortality rate up to eightfold in preterm infants and more than 40-fold in term infants. Although the incidence of GBS early-onset sepsis is not changing, we speculate that the improved birth weight-specific survival rate and the changing clinical presentation are due to improved intrapartum and neonatal management. C1 WALTER REED ARMY MED CTR, DEPT PEDIAT, WASHINGTON, DC 20307 USA. EMORY UNIV, DEPT PEDIAT, ATLANTA, GA 30322 USA. UNIV MISSOURI, DEPT PEDIAT, KANSAS CITY, MO 64110 USA. UNIV COLORADO HLTH SCI, DEPT PEDIAT, DENVER, CO USA. UNIFORMED SERV UNIV HLTH SCI, DEPT PREVENT MED & BIOMETR, BETHESDA, MD 20814 USA. RP WEISMAN, LE (reprint author), UNIFORMED SERV UNIV HLTH SCI, DEPT PEDIAT, 4301 JONES BRIDGE RD, BETHESDA, MD 20814 USA. NR 30 TC 84 Z9 84 U1 0 U2 1 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0022-3476 EI 1097-6833 J9 J PEDIATR-US JI J. Pediatr. PD SEP PY 1992 VL 121 IS 3 BP 428 EP 433 PG 6 WC Pediatrics SC Pediatrics GA JM255 UT WOS:A1992JM25500018 PM 1517922 ER PT J AU WEISMAN, LE STOLL, BJ KUESER, TJ RUBIO, TT FRANK, CG HEIMAN, HS SUBRAMANIAN, KNS HANKINS, CT ANTHONY, BF CRUESS, DF HEMMING, VG FISCHER, GW AF WEISMAN, LE STOLL, BJ KUESER, TJ RUBIO, TT FRANK, CG HEIMAN, HS SUBRAMANIAN, KNS HANKINS, CT ANTHONY, BF CRUESS, DF HEMMING, VG FISCHER, GW TI INTRAVENOUS IMMUNE GLOBULIN THERAPY FOR EARLY-ONSET SEPSIS IN PREMATURE NEONATES SO JOURNAL OF PEDIATRICS LA English DT Article ID GROUP-B STREPTOCOCCUS; OPSONIC ACTIVITY; ESCHERICHIA-COLI; POLYSACCHARIDE VACCINE; ANTIBODY-LEVELS; IMMUNOGLOBULIN; INFANTS; INFECTION; SERUM; PREVENTION AB Newborn infants may have IgG deficiencies that increase their susceptibility to bacterial infection. To determine whether intravenous immune globulin (IVIG) therapy improves survival rates in early-onset sepsis, we prospectively entered 753 neonates (birth weight 500 to 2000 gm, gestation less-than-or-equal-to 34 weeks, age less-than-or-equal-to 12 hours) into a multicenter, double-blind, controlled trial. Blood culture specimens were obtained and infants randomly assigned to receive 10 ml (per kilogram) intravenously of a selected IVIG (500 mg/kg) or albumin (5 mg/kg) preparation. Maternal and neonatal risk factors were not different between groups. Thirty-one babies (4.2%) had early-onset sepsis; the causative organisms were group B streptococcus (12 babies), Escherichia coli (6), and others (13). Of these 31 neonates, 7 (23%) died. Total serum IgG was higher for 7 days after IVIG therapy than after albumin treatment (p <0.05). During these 7 days, 5 (30%) of 17 albumin-treated and none of 14 IVIG-treated patients died (p <0.05). The survival rate at 56 days of age, however, was not significantly improved. Group B streptococcus type-specific IgG antibody was significantly increased after IVIG treatment and appeared to be related to the amount of IVIG specific antibody. Infusion-related adverse reactions were less frequent in patients receiving IVIG therapy (0.5%) than in those receiving albumin. The IVIG therapy in neonates with early-onset sepsis, while reducing the early mortality rate, did not significantly affect the overall survival rate. Further studies are necessary to confirm these findings and to determine more effective therapeutic regimens. C1 CHILDRENS HOSP KINGS DAUGHTERS, DEPT PEDIAT, NORFOLK, VA USA. UNIV CALIF LOS ANGELES, LOS ANGELES CTY HARBOR MED CTR, DEPT PEDIAT, TORRANCE, CA 90509 USA. FITZSIMONS ARMY MED CTR, DEPT PEDIAT, AURORA, CO 80045 USA. UNIFORMED SERV UNIV HLTH SCI, DEPT PREVENT MED & BIOMETR, BETHESDA, MD 20814 USA. DARNALL ARMY HOSP, DEPT PEDIAT, FT HOOD, TX USA. WALTER REED ARMY MED CTR, DEPT PEDIAT, WASHINGTON, DC 20307 USA. EMORY UNIV, DEPT PEDIAT, ATLANTA, GA 30322 USA. EMORY UNIV, DEPT PEDIAT, ATLANTA, GA 30322 USA. BROOKE ARMY MED CTR, DEPT PEDIAT, FT SAM HOUSTON, TX 78234 USA. BROOKE ARMY MED CTR, DEPT PEDIAT, FT SAM HOUSTON, TX 78234 USA. RP WEISMAN, LE (reprint author), UNIFORMED SERV UNIV HLTH SCI, DEPT PEDIAT, 4301 JONES BRIDGE RD, BETHESDA, MD 20814 USA. FU NIAID NIH HHS [R01-AI26257] NR 48 TC 46 Z9 47 U1 0 U2 1 PU MOSBY-ELSEVIER PI NEW YORK PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA SN 0022-3476 EI 1097-6833 J9 J PEDIATR-US JI J. Pediatr. PD SEP PY 1992 VL 121 IS 3 BP 434 EP 443 DI 10.1016/S0022-3476(05)81802-5 PG 10 WC Pediatrics SC Pediatrics GA JM255 UT WOS:A1992JM25500019 PM 1517923 ER PT J AU STEIDLEY, KE THOMPSON, SH MCQUADE, MJ STRONG, SL SCHEIDT, MJ VANDYKE, TE AF STEIDLEY, KE THOMPSON, SH MCQUADE, MJ STRONG, SL SCHEIDT, MJ VANDYKE, TE TI A COMPARISON OF LYMPHOCYTE-T4-T8 RATIO IN THE PERIODONTAL LESION OF HEALTHY AND HIV-POSITIVE PATIENTS SO JOURNAL OF PERIODONTOLOGY LA English DT Article DE PERIODONTITIS; HIV VIRUS; LYMPHOCYTES-T4; LYMPHOCYTES-T8 ID T-CELL REGULATION; DISEASE; TISSUES; POPULATIONS; INDUCER; IMMUNOREGULATION; IMMUNOLOGY; ACTIVATION; SUBSETS; HELPER AB PREVIOUS REPORTS DESCRIBE A CHARACTERISTIC, rapidly progressive, periodontitis that is unique to patients who are seropositive for HIV antibody (Western blot +). The purpose of this study was to compare the T4 and T8 lymphocyte subpopulations in the peripheral blood and periodontal lesions of these HIV patients with those of healthy controls. T-cell subsets in peripheral blood were quantified by flow cytometry. The values from this analysis were used to calculate the peripheral T4:T8 lymphocyte ratio for each patient. Gingival tissue (papilla) was obtained from 8 HIV + patients and from 6 healthy HIV - control patients during routine gingival surgery. The T-cell subpopulations in the gingival tissue were determined using serial cryostat sections that were labeled with monoclonal antibodies for T4 and T8 cells and developed using an avidin-biotin-peroxidase system. Six sections were taken from each of the 14 tissue specimens (one per patient). The sections were examined at 450 x and the mean number of T4 and T8 cells calculated for each section. These mean values were then used to determine the T4:T8 lymphocyte ratio for each tissue specimen. The peripheral blood analysis revealed a mean serum T4:T8 ratio of (2.07 +/- 0.455) for the controls and (0.58 +/- 0.26) for the HIV patients. The significantly lower T4:T8 ratio in HIV patients is consistent with their diagnosis. Although the results indicated that the mean T4:T8 lymphocyte ratio in the gingiva of controls was highly variable (2.70 +/- 1.344), the gingiva of HIV patients consistently exhibited a complete absence of T-cells. The lack of locally present immune effector and regulatory cells in HIV seropositive patients with periodontal disease could in part explain the characteristic and rapidly progressive nature of their periodontal disease. C1 UNIV ROCHESTER,EASTMAN DENT CTR,ROCHESTER,NY 14627. BAYLOR COLL DENT,DALLAS,TX 75246. RP STEIDLEY, KE (reprint author), USA,FT GORDON,GA 30905, USA. FU NIDCR NIH HHS [DE06436] NR 28 TC 20 Z9 22 U1 0 U2 0 PU AMER ACAD PERIODONTOLOGY PI CHICAGO PA 737 NORTH MICHIGAN AVENUE, SUITE 800, CHICAGO, IL 60611-2690 SN 0022-3492 J9 J PERIODONTOL JI J. Periodont. PD SEP PY 1992 VL 63 IS 9 BP 753 EP 756 PG 4 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA JP674 UT WOS:A1992JP67400006 PM 1361945 ER PT J AU BURKE, LA KRISHNAN, PN MORRIS, RE FAMINI, GR AF BURKE, LA KRISHNAN, PN MORRIS, RE FAMINI, GR TI COMPARISON OF MNDO, AM1 AND PM3 ROTATIONAL BARRIERS IN BRANCHED ALKANES SO JOURNAL OF PHYSICAL ORGANIC CHEMISTRY LA English DT Note ID MOLECULAR-MODELS; GROUND-STATES; PARAMETERS; BUTANE AB The MNDO, AM1 and PM3 semi-empirical methods were used to calculate the equilibrium points and transition-state structures of the rotational barriers of ethane and all methyl-substituted propanes and butanes. Force constant methods were used to ensure proper geometries. In general, AM1 barriers tend to be lower than MNDO calculated ones, which are themselves generally lower than experiment. The PM3 values are closest to experiment, ranging from slightly above to slightly below the experimental values. The complexity of various possible rotational minima makes the development of empirical rules to predict barrier heights difficult. C1 USA,CTR CHEM RES DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010. RUTGERS STATE UNIV,DEPT CHEM,CAMDEN,NJ 08102. COPPIN STATE COLL,DEPT NAT SCI,BALTIMORE,MD 21216. NR 14 TC 6 Z9 6 U1 0 U2 3 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0894-3230 J9 J PHYS ORG CHEM JI J. Phys. Org. Chem. PD SEP PY 1992 VL 5 IS 9 BP 614 EP 616 DI 10.1002/poc.610050910 PG 3 WC Chemistry, Organic; Chemistry, Physical SC Chemistry GA JN524 UT WOS:A1992JN52400009 ER PT J AU WEI, YC HUDSON, SM MAYER, JM KAPLAN, DL AF WEI, YC HUDSON, SM MAYER, JM KAPLAN, DL TI THE CROSS-LINKING OF CHITOSAN FIBERS SO JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY LA English DT Article DE CHITIN; CHITOSAN; FIBERS; CROSS-LINKING; EPICHLOROHYDRIN; FILM AB A need exists for the development of totally biodegradable packaging materials. Chitosan is an under-utilized polymer which possesses many of the desired characteristics for this application. This article describes the crosslinking of chitosan fibers. Epichlorohydrin (ECH) was selected as a convenient base catalyzed crosslinking agent. The strength of chitosan fibers, especially wet tenacity, is improved by crosslinking. C1 N CAROLINA STATE UNIV,FIBER & POLYMER SCI PROGRAM,BOX 8301,RALEIGH,NC 27695. USA,NATICK RES CTR,DEPT BIOTECHNOL,NATICK,MA 01760. NR 8 TC 126 Z9 145 U1 2 U2 25 PU JOHN WILEY & SONS INC PI NEW YORK PA 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0887-624X J9 J POLYM SCI POL CHEM JI J. Polym. Sci. Pol. Chem. PD SEP PY 1992 VL 30 IS 10 BP 2187 EP 2193 DI 10.1002/pola.1992.080301013 PG 7 WC Polymer Science SC Polymer Science GA JH815 UT WOS:A1992JH81500013 ER PT J AU BARATTA, FI UNDERWOOD, JH AF BARATTA, FI UNDERWOOD, JH TI NOTCH DIMENSIONS FOR 3-POINT BEND FRACTURE SPECIMENS BASED ON COMPLIANCE ANALYSES SO JOURNAL OF TESTING AND EVALUATION LA English DT Article DE FRACTURE TOUGHNESS; COMPLIANCE; STRENGTH OF MATERIALS; BENDING BEAM; NOTCH ANALYSIS AB Load-line compliance was calculated for various three-point bend specimens containing finite width notches and cutouts, using methods of engineering strength of materials and elastic superposition. Comparison of compliance results for notched specimens with results for the ideal zero width crack was used to propose two basic notch configurations for fracture testing. A relatively wide notch that could be produced by conventional manufacturing methods resulted in load-line compliance values 10% or more above those of the ideal crack case. A narrow notch that could be produced by electric-discharge machining resulted in compliance values much closer to those of the ideal crack case. C1 USA,CTR ARMAMENT RES DEV & ENGN,WATERVLIET,NY. RP BARATTA, FI (reprint author), USA,MAT TECHNOL LAB,WATERTOWN,MA 02172, USA. NR 6 TC 2 Z9 2 U1 0 U2 0 PU AMER SOC TESTING MATERIALS PI W CONSHOHOCKEN PA 100 BARR HARBOR DR, W CONSHOHOCKEN, PA 19428-2959 SN 0090-3973 J9 J TEST EVAL JI J. Test. Eval. PD SEP PY 1992 VL 20 IS 5 BP 343 EP 348 PG 6 WC Materials Science, Characterization & Testing SC Materials Science GA JY514 UT WOS:A1992JY51400003 ER PT J AU SAMLASKA, CP HANSEN, MF AF SAMLASKA, CP HANSEN, MF TI INTRAOSSEOUS EPIDERMOID CYSTS SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Note ID BONES; SKIN C1 TRIPLER ARMY MED CTR,DEPT RADIOL,HONOLULU,HI 96859. RP SAMLASKA, CP (reprint author), TRIPLER ARMY MED CTR,DERMATOL SERV,HONOLULU,HI 96859, USA. NR 15 TC 4 Z9 4 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD SEP PY 1992 VL 27 IS 3 BP 454 EP 455 DI 10.1016/S0190-9622(08)80881-X PG 2 WC Dermatology SC Dermatology GA JL250 UT WOS:A1992JL25000017 PM 1401285 ER PT J AU TAYLOR, AJ ROGAN, KM VIRMANI, R AF TAYLOR, AJ ROGAN, KM VIRMANI, R TI SUDDEN CARDIAC DEATH ASSOCIATED WITH ISOLATED CONGENITAL CORONARY-ARTERY ANOMALIES SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY LA English DT Article ID PULMONARY TRUNK; ORIGIN; VALSALVA; SINUS; AORTA AB Objectives and Background. Congenital coronary anomalies are associated with sudden death and exercise-related death. Clarification of the risk and mechanisms of sudden death in patients with coronary anomalies may aid in decisions on intervention. Methods. The clinicopathologic records of 242 patients with isolated coronary artery anomalies were reviewed for information on mode of death and abnormalities of the initial segment (acute angle takeoff, valvelike ridges or aortic intramural segments) and course of the anomalous coronary artery. Results. Cardiac death occurred in 142 patients (59%); 78 (32%) of these deaths occurred suddenly. Of sudden deaths, 45% occurred with exercise. Sudden death (28 of 49, 57%) and exercise-related death (18 of 28, 64%) were most common with origin of the left main coronary artery from the right coronary sinus. Anomalous origin of the right coronary artery from the left coronary sinus was also commonly associated with exercise-related sudden death (6 of 13 sudden deaths, 46%). High risk anatomy involved abnormalities of the initial coronary artery segment or coursing of the anomalous artery between the pulmonary artery and aorta. Younger patients (less-than-or-equal-to 30 years old) were significantly more likely than older patients (greater-than-or-equal-to 30 years old) to die suddenly (62% vs. 12%, p = 0.0001) or during exercise (40% vs. 2%, p = 0.00001) despite their low frequency of significant atherosclerotic coronary artery disease (1% vs. 40%, p 0.00001). Conclusions. Younger patients (less-than-or-equal-to 30 years old) with an isolated coronary artery anomaly are at risk of dying suddenly and with exercise. Therefore, greater effort for early detection and surgical repair of these lesions is warranted. C1 ARMED FORCES INST PATHOL,DEPT CARDIOVASC PATHOL,WASHINGTON,DC 20306. WALTER REED ARMY MED CTR,DEPT MED,WASHINGTON,DC 20307. NR 13 TC 394 Z9 408 U1 1 U2 3 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0735-1097 J9 J AM COLL CARDIOL JI J. Am. Coll. Cardiol. PD SEP PY 1992 VL 20 IS 3 BP 640 EP 647 PG 8 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA JL257 UT WOS:A1992JL25700019 PM 1512344 ER PT J AU PAGAC, BB TURELL, MJ OLSEN, GH AF PAGAC, BB TURELL, MJ OLSEN, GH TI EASTERN EQUINE ENCEPHALOMYELITIS VIRUS AND CULISETA-MELANURA ACTIVITY AT THE PATUXENT-WILDLIFE-RESEARCH-CENTER, 1985-90 SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Note ID ENCEPHALITIS-VIRUS; WHOOPING CRANES AB Mosquito population densities, virus isolations and seroconversion in sentinel quail were used to monitor eastern equine encephalomyelitis virus (EEE) activity at the Patuxent Wildlife Research Center, Laurel, Maryland, from 1985 through 1990. A dramatic increase in the number of Culiseta melanura collected in 1989, as compared with the 3 previous years, was associated with virus isolations from this species (5/75 pools; n = 542 mosquitoes) and with seroconversion in sentinel quail (4/22 birds positive). This was the first detection of EEE virus activity in this area since a 1984 EEE outbreak killed 7 whooping cranes. C1 US FISH & WILDLIFE SERV,PATUXENT WILDLIFE RES CTR,LAUREL,MD 20708. USA,MED RES INST INFECT DIS,DEPT EPIDEMIOL,DIV DIS ASSESSMENT,FREDERICK,MD 21702. RP PAGAC, BB (reprint author), USA ENVIRONM HYG ACT N,DIV ENTOMOL SCI,FT GEORGE G MEADE,MD 20755, USA. NR 7 TC 6 Z9 6 U1 0 U2 0 PU AMER MOSQUITO CONTROL ASSN INC PI LAKE CHARLES PA 707-A EAST PRIEN LAKE ROAD, PO BOX 5416, LAKE CHARLES, LA 70606-5416 SN 8756-971X J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD SEP PY 1992 VL 8 IS 3 BP 328 EP 330 PG 3 WC Entomology SC Entomology GA JR023 UT WOS:A1992JR02300026 PM 1357091 ER PT J AU NICELY, ER MAGGIO, MI KUHN, EJ AF NICELY, ER MAGGIO, MI KUHN, EJ TI THE USE OF A CYSTOSCOPICALLY PLACED COBRA CATHETER FOR DIRECTED IRRIGATION OF LOWER POLE CALICEAL STONES DURING EXTRACORPOREAL SHOCK-WAVE LITHOTRIPSY SO JOURNAL OF UROLOGY LA English DT Article DE URINARY CALCULI; LITHOTRIPSY; CATHETERIZATION AB As the general experience with extracorporeal shock wave lithotripsy (ESWL) for renal calculi broadens, it is increasingly evident that the clearance of stone fragments in lower pole calices needs to be improved. The stone-free rate after treatment for lower caliceal stones is consistently less than that for other upper tract locations. Use of a cystoscopically placed cobra catheter for directed irrigation during ESWL resulted in an increase of our lower caliceal stone-free rate at 1 and 3 months of followup to 71% (15 of 21) compared to 33% (8 of 24) of randomly selected controls at 1 month and 54% (13 of 24) at 3 months. We conclude that pre-ESWL placement of a cobra catheter into the lower pole calix and intermittent irrigation during the procedure are potentially useful adjuncts in the successful treatment of lower caliceal calculi. RP NICELY, ER (reprint author), WALTER REED ARMY MED CTR,DEPT UROL,WASHINGTON,DC 20307, USA. NR 12 TC 28 Z9 28 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-5347 J9 J UROLOGY JI J. Urol. PD SEP PY 1992 VL 148 IS 3 BP 1036 EP 1039 PN 2 PG 4 WC Urology & Nephrology SC Urology & Nephrology GA JL740 UT WOS:A1992JL74000017 PM 1507325 ER PT J AU MAGGIO, MI NICELY, ER PEPPAS, DS GORMLEY, TS BROWN, CE AF MAGGIO, MI NICELY, ER PEPPAS, DS GORMLEY, TS BROWN, CE TI AN EVALUATION OF 646 STONE PATIENTS TREATED ON THE HM4 EXTRACORPOREAL SHOCK-WAVE LITHOTRIPTOR SO JOURNAL OF UROLOGY LA English DT Article DE LITHOTRIPSY; KIDNEY CALCULI; URETERAL CALCULI ID URETERAL CALCULI; EXPERIENCE; ANESTHESIA; KIDNEY AB Extracorporeal shock wave lithotripsy (ESWL) has become the preferred treatment modality for the majority of urinary tract calculi. This form of treatment boasts excellent patient acceptance and has significantly reduced the need for surgical intervention. An evaluation of our first 646 patients undergoing 722 ESWL treatments at Walter Reed Army Medical Center revealed an overall stone-free rate at 1 and 3 months of 52% and 79%, respectively. The exact location of each stone within the kidney and ureter further determined the stone-free rates at 1 and 3 months. Stone-free rates at 3 months ranged from 89% for renal pelvic stones to 64% for lower pole caliceal stones. Upper third ureteral stones treated in situ without stenting resulted in a 74% stone-free rate at 3 months. This rate increased to 85% when these patients were stented and treated in situ. Although statistically insignificant, when the upper third ureteral stones were manipulated into and treated in the renal pelvis (31% of our patient population) the 3-month stone-free rate increased to 87%. Attempts were made to stent all ureteral stones before treatment. The stone-free rate at 3 months was 86% for mid third ureteral stones and 81% for lower third ureteral stones. The overall retreatment rate was 11.8% with a complication rate of 7.6% and a 6.3% post-ESWL intervention rate (open or percutaneous surgery, stent or percutaneous nephrostomy placement). RP MAGGIO, MI (reprint author), WALTER REED ARMY MED CTR,DEPT UROL,WASHINGTON,DC 20307, USA. NR 24 TC 11 Z9 12 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-5347 J9 J UROLOGY JI J. Urol. PD SEP PY 1992 VL 148 IS 3 BP 1114 EP 1119 PN 2 PG 6 WC Urology & Nephrology SC Urology & Nephrology GA JL740 UT WOS:A1992JL74000040 PM 1507347 ER PT J AU HORLING, J LUNDKVIST, A HUGGINS, JW NIKLASSON, B AF HORLING, J LUNDKVIST, A HUGGINS, JW NIKLASSON, B TI ANTIBODIES TO PUUMALA VIRUS IN HUMANS DETERMINED BY NEUTRALIZATION TEST SO JOURNAL OF VIROLOGICAL METHODS LA English DT Article DE HANTAVIRUS; PUUMALA VIRUS; NEUTRALIZATION TEST; ELISA ID RENAL SYNDROME VIRUS; HEMORRHAGIC-FEVER; NEPHROPATHIA EPIDEMICA; AGENT AB An assay for detection of neutralizing antibodies to Puumala virus using 96-well microtiter plates (NT-ELISA) was developed and evaluated. The test proved to have similar sensitivity and specificity as an IgG ELISA and indirect immunofluorescence test, when screening 187 sera (with an antibody prevalence rate of 19%) from normal populations in an endemic area of Nephropathia epidemica (NE) in Sweden. NE-patients monitored for 2 years had neutralizing antibodies in early sera collected 1-4 days after the onset of disease with a continuous increase in neutralizing antibodies with time. Furthermore, high titers of neutralizing antibodies were detected 10-20 years post-infection. This neutralization assay was also evaluated as a screening method in the production of monoclonal antibodies. The format of the NT-ELISA makes it feasible to screen a large number of specimens with results similar to the standard plaque or focus-reduction neutralization tests. C1 USA, MED RES INST INFECT DIS, DEPT VIROL, FREDERICK, MD 21701 USA. NATL DEF RES ESTAB, UNEA, SWEDEN. RP HORLING, J (reprint author), NATL BACTERIOL LAB, KAROLINSKA INST, DEPT VIROL, S-10521 STOCKHOLM, SWEDEN. NR 11 TC 32 Z9 33 U1 1 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-0934 J9 J VIROL METHODS JI J. Virol. Methods PD SEP PY 1992 VL 39 IS 1-2 BP 139 EP 147 DI 10.1016/0166-0934(92)90132-W PG 9 WC Biochemical Research Methods; Biotechnology & Applied Microbiology; Virology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Virology GA JQ073 UT WOS:A1992JQ07300013 PM 1358908 ER PT J AU WARREN, RQ ANDERSON, SA NKYA, WMMM SHAO, JF HENDRIX, CW MELCHER, GP REDFIELD, RR KENNEDY, RC AF WARREN, RQ ANDERSON, SA NKYA, WMMM SHAO, JF HENDRIX, CW MELCHER, GP REDFIELD, RR KENNEDY, RC TI EXAMINATION OF SERA FROM HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 (HIV-1)-INFECTED INDIVIDUALS FOR ANTIBODIES REACTIVE WITH PEPTIDES CORRESPONDING TO THE PRINCIPAL NEUTRALIZING DETERMINANT OF HIV-1 GP120 AND FOR INVITRO NEUTRALIZING ACTIVITY SO JOURNAL OF VIROLOGY LA English DT Article ID HUMAN MONOCLONAL-ANTIBODY; SYNTHETIC PEPTIDES; ENVELOPE GLYCOPROTEIN; INFECTED INDIVIDUALS; ACID SEQUENCE; AMINO-ACIDS; EPITOPE; DOMAIN; CHIMPANZEES; SPECIFICITY AB Sera from human immunodeficiency virus type 1 (HIV-1)-infected individuals from the United States and Tanzania were examined for antibody reactivity to four synthetic peptides which corresponded to the principal neutralizing determinant from the V3 region of HIV-1 gp120. We observed that the majority of sera from both countries contained antibodies reactive with a V3 peptide whose sequence is based on that of the HIV-1 MN isolate. We were unable to establish a relationship between the presence of V3-reactive antibodies, as measured by enzyme-linked immunosorbent assay and neutralization of homologous HIV-1 isolates, in sera from either the United States or Tanzania. We observed that some sera which contained high antibody titers to the V3 peptides failed to neutralize HIV-1, while others with no antibody reactivity to the panel of V3 peptides exhibited in vitro neutralizing activity. These results suggest that neutralizing epitopes exist outside the V3 loop and that the presence of V3-reactive antibodies in sera does not imply in vitro neutralization of the homologous HIV-1 isolate. In addition, it appears that the V3 loop may consist of both neutralizing and nonneutralizing epitopes. The identification of neutralizing as well as nonneutralizing epitopes will be important for the design of potential HIV-1 vaccines. C1 SW FDN BIOMED RES,DEPT VIROL & IMMUNOL,SAN ANTONIO,TX 78284. SW FDN BIOMED RES,CTR AIDS RES,SAN ANTONIO,TX 78284. KILIMANJARO CHRISTIAN MED CTR,MOSHI,TANZANIA. MUHIMBILI MED CTR,DAR ES SALAAM,TANZANIA. WILFORD HALL USAF MED CTR,LACKLAND AFB,TX 78236. WALTER REED ARMY MED CTR,DEPT RETROVIRAL RES,ROCKVILLE,MD 20850. RI Hendrix, Craig/G-4182-2014 OI Hendrix, Craig/0000-0002-5696-8665 FU NIAID NIH HHS [AI28696, AI26462] NR 44 TC 27 Z9 27 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0022-538X J9 J VIROL JI J. Virol. PD SEP PY 1992 VL 66 IS 9 BP 5210 EP 5215 PG 6 WC Virology SC Virology GA JJ198 UT WOS:A1992JJ19800005 PM 1380094 ER PT J AU SUMIYOSHI, H HOKE, CH TRENT, DW AF SUMIYOSHI, H HOKE, CH TRENT, DW TI INFECTIOUS JAPANESE ENCEPHALITIS-VIRUS RNA CAN BE SYNTHESIZED FROM INVITRO-LIGATED CDNA TEMPLATES SO JOURNAL OF VIROLOGY LA English DT Article ID YELLOW-FEVER VIRUS; FULL-LENGTH CDNA; NUCLEOTIDE-SEQUENCE; MONOCLONAL-ANTIBODIES; VIRAL POLYPROTEIN; POLYMERASE; PROTEASE; MUTATIONS; VACCINE; FLAVIVIRUSES AB Japanese encephalitis virus (JEV) is a positive-stranded enveloped RNA virus that belongs to the family Flaviviridae. Genomic JEV RNA is approximately 11 kb long and encodes 10 proteins, 3 structural and 7 nonstructural. A full-length cDNA copy of the JEV genome was constructed by in vitro ligation of two cDNA fragments which encode the 5' (nucleotide positions 1 to 5576) and 3' (nucleotide positions 5577 to 10976) halves of the genome. T7 RNA polymerase transcripts of the ligated full-length cDNA template were infectious when transfected into BHK-21 cells. To identify the recombinant virus, a silent mutation was introduced into the clone encoding the 3' half of the genome, which abolished an XbaI site at nucleotide position 9131. Virus recovered by transfection with the transcripts contained this silent mutation, confirming its identity. Recombinant and parent viruses were identical with respect to growth and plaque production in BHK-21 cells, envelope protein expression in C6/36 cells, and neurovirulence and immunogenicity in mice. Repeated attempts to obtain infectious RNA by transcription from full-length JEV genome cDNA templates cloned into plasmid vectors were unsuccessful. Synthesis of infectious JEV RNA from in vitro-ligated JEV cDNA templates will be useful for molecular and genetic studies of flavivirus replication and virulence. C1 CTR DIS CONTROL,NATL CTR INFECT DIS,DIV VECTOR BORNE INFECT DIS,FT COLLINS,CO 80522. RP SUMIYOSHI, H (reprint author), WALTER REED ARMY MED CTR,DEPT VIRUS DIS,WASHINGTON,DC 20307, USA. NR 38 TC 103 Z9 121 U1 0 U2 2 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0022-538X J9 J VIROL JI J. Virol. PD SEP PY 1992 VL 66 IS 9 BP 5425 EP 5431 PG 7 WC Virology SC Virology GA JJ198 UT WOS:A1992JJ19800031 PM 1501281 ER PT J AU SMITH, JM VINCENT, CL AF SMITH, JM VINCENT, CL TI SHOALING AND DECAY OF 2 WAVE-TRAINS ON BEACH SO JOURNAL OF WATERWAY PORT COASTAL AND OCEAN ENGINEERING-ASCE LA English DT Article ID GRAVITY-WAVES; WATER AB Shoaling and decay of irregular wave trains with two distinct frequency peaks are simulated in a wave flume. The relative energy in each wave train, the closeness of the frequency peaks, and the total wave energy were varied over 12 cases. Wave-gauge measurements across the 1:30 plane slope in the flume show that linear superposition of single-peaked wave trains or lumping all energy into the dominant wave train are not satisfactory representations of multiple wave trains. The measurements also show that the wave train with the low-frequency peak dominates in the surf zone. Waves with the low-frequency peak appear unaffected by the second wave train, but the high-frequency wave train decays faster in the presence of the low-frequency waves. The variation of wave height through shoaling and breaking depends on the relative amount of energy in each of the wave trains and the closeness of the peak frequencies. RP SMITH, JM (reprint author), USA,COASTAL ENGN RES CTR,ENGN WATERWAYS EXPT STN,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 15 TC 17 Z9 17 U1 0 U2 0 PU ASCE-AMER SOC CIVIL ENGINEERS PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-950X J9 J WATERW PORT C-ASCE JI J. Waterw. Port Coast. Ocean Eng.-ASCE PD SEP-OCT PY 1992 VL 118 IS 5 BP 517 EP 533 DI 10.1061/(ASCE)0733-950X(1992)118:5(517) PG 17 WC Engineering, Civil; Engineering, Ocean; Water Resources SC Engineering; Water Resources GA JK692 UT WOS:A1992JK69200005 ER PT J AU CARSON, RT GIVENS, JH SAVAGE, HS LEE, YW RIGSBEE, JM CROISANT, WJ AF CARSON, RT GIVENS, JH SAVAGE, HS LEE, YW RIGSBEE, JM CROISANT, WJ TI EFFECTS OF OXYGEN ON THE ELECTRICAL AND ELECTROCHEMICAL PROPERTIES OF ION-PLATED TITANIUM NITRIDE SO MATERIALS LETTERS LA English DT Article ID THIN-FILMS; COATINGS; TIN; TOOLS AB Oxygen has been introduced into reactively ion-plated TiN to determine its effect on the film microstructure, resistivity and electrochemical properties. Oxygen levels incorporated into the films varied from 5 a/o to a maximum of 35 a/o as indicated by Auger electron spectroscopy (AES). While no oxide phases were revealed by X-ray diffraction (XRD), results indicate increasing degrees of microcrystallinity with increasing bulk oxygen content. From electrochemical testing, films containing higher oxygen content appeared to have greater chemical stability; however, four-point probe analysis indicates increasing resistivity and the onset of insulating properties as the oxygen content in the films increases above 30 a/o. C1 USA,CONSTRUCT ENGN RES LAB,CHAMPAIGN,IL 61824. RP CARSON, RT (reprint author), UNIV ILLINOIS,DEPT MAT SCI & ENGN,1304 W GREEN ST,URBANA,IL 61801, USA. NR 12 TC 1 Z9 1 U1 1 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-577X J9 MATER LETT JI Mater. Lett. PD SEP PY 1992 VL 14 IS 5-6 BP 313 EP 317 DI 10.1016/0167-577X(92)90044-K PG 5 WC Materials Science, Multidisciplinary; Physics, Applied SC Materials Science; Physics GA JN037 UT WOS:A1992JN03700015 ER PT J AU VANBLARICUM, V KUMAR, A AF VANBLARICUM, V KUMAR, A TI COMPUTERIZED MONITORING OF CATHODIC PROTECTION SYSTEMS FOR UNDERGROUND STRUCTURES SO MATERIALS PERFORMANCE LA English DT Article AB Cost-effective corrosion control of underground steel gas piping and storage tanks requires that cathodic protection (CP) systems operate properly and meet the criteria of regulatory agencies. Data must be constantly monitored and system faults must be correctly diagnosed. The CP Diagnostic computer program helps meet the requirements for impressed current and sacrificial CP systems. Implementation of the system is discussed. RP VANBLARICUM, V (reprint author), USA,CONSTRUCT ENGN RES LAB,POB 9005,CHAMPAIGN,IL 61826, USA. NR 3 TC 2 Z9 2 U1 0 U2 0 PU NATL ASSN CORROSION ENG PI HOUSTON PA 1440 SOUTH CREEK DRIVE, HOUSTON, TX 77084-4906 SN 0094-1492 J9 MATER PERFORMANCE JI Mater. Perform. PD SEP PY 1992 VL 31 IS 9 BP 34 EP 39 PG 6 WC Materials Science, Characterization & Testing SC Materials Science GA JQ578 UT WOS:A1992JQ57800008 ER PT J AU CARLIN, K CARLIN, S AF CARLIN, K CARLIN, S TI HYPOTHYROID INDUCED HYPOMETABOLIC STATE AS A POSSIBLE DIAGNOSTIC AND THERAPEUTIC MANEUVER SO MEDICAL HYPOTHESES LA English DT Article ID THYROID-HORMONE ACTION; RAT; TRIIODOTHYRONINE; CARCINOMA; GROWTH; LEVEL; CELLS AB Diseased cells possibly function autonomously without as much dependance upon metabolic cues such as thyroid hormone by comparison to normal cells. Therefore if reversible hypothyroidism can be induced briefly in euthyroid patients, conceivably normal cells can be induced into a hypometabolic state while the diseased cells continue at their baseline or near baseline metabolic level. This induced difference could be utilized to isolate and target abnormal cells better. RP CARLIN, K (reprint author), BROOKE ARMY MED CTR,DEPT ENDOCRINOL,SAN ANTONIO,TX 78234, USA. NR 23 TC 3 Z9 3 U1 0 U2 0 PU CHURCHILL LIVINGSTONE PI EDINBURGH PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE, LEITH WALK, EDINBURGH, MIDLOTHIAN, SCOTLAND EH1 3AF SN 0306-9877 J9 MED HYPOTHESES JI Med. Hypotheses PD SEP PY 1992 VL 39 IS 1 BP 49 EP 52 DI 10.1016/0306-9877(92)90139-4 PG 4 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA JQ904 UT WOS:A1992JQ90400008 PM 1435392 ER PT J AU MAGNER, J KLIBANSKI, A FEIN, H SMALLRIDGE, R BLACKARD, W YOUNG, W FERRISS, JB MURPHY, D KANE, J RUBIN, D AF MAGNER, J KLIBANSKI, A FEIN, H SMALLRIDGE, R BLACKARD, W YOUNG, W FERRISS, JB MURPHY, D KANE, J RUBIN, D TI RICIN AND LENTIL LECTIN AFFINITY-CHROMATOGRAPHY REVEALS OLIGOSACCHARIDE HETEROGENEITY OF THYROTROPIN SECRETED BY 12 HUMAN PITUITARY-TUMORS SO METABOLISM-CLINICAL AND EXPERIMENTAL LA English DT Article ID HORMONE; TSH; BIOSYNTHESIS; HYPERTHYROIDISM; BIOACTIVITY; SIALYLATION; SPECIFICITY; COMPONENTS; ADENOMA; SUBUNIT C1 REG HOSP CORK,CORK,IRELAND. HARVARD UNIV,SCH MED,BOSTON,MA 02115. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,RICHMOND,VA 23298. MAYO CLIN & MAYO FDN,ROCHESTER,MN 55905. RP MAGNER, J (reprint author), UNIV ILLINOIS,HUMANA HOSP MICHAEL REESE,DIV ENDOCRINOL,31ST & LAKE SHORE DR,CHICAGO,IL 60616, USA. FU NIDDK NIH HHS [DK-38835]; PHS HHS [233-4706] NR 23 TC 26 Z9 26 U1 0 U2 1 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0026-0495 J9 METABOLISM JI Metab.-Clin. Exp. PD SEP PY 1992 VL 41 IS 9 BP 1009 EP 1015 DI 10.1016/0026-0495(92)90129-X PG 7 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA JL947 UT WOS:A1992JL94700014 PM 1518416 ER PT J AU RAMESH, KT COATES, RS AF RAMESH, KT COATES, RS TI MICROSTRUCTURAL INFLUENCES ON THE DYNAMIC-RESPONSE OF TUNGSTEN HEAVY ALLOYS SO METALLURGICAL TRANSACTIONS A-PHYSICAL METALLURGY AND MATERIALS SCIENCE LA English DT Article; Proceedings Paper CT SYMP ON REACTIONS SYNTHESIS OF MATERIALS, AT THE 1991 ANNUAL MEETING OF THE MINERALS, METALS AND MATERIALS SOC CY FEB 17-21, 1991 CL NEW ORLEANS, LA SP MINERALS MET & MAT SOC AB The influence of tungsten content, swaging, and grain size on the dynamic behavior of commercially available tungsten-nickel-iron (W-Ni-Fe) alloys has been examined using the compression Kolsky bar. The observed flow stresses increase with increasing tungsten content and with degree of swaging but are essentially independent of grain size for these compressive deformations. Further, the flow stresses sustained by these materials have a distinct dependence on strain rate, in that the flow stress increases by at least 20 pct over a range from 10(-4) s-1 to 7 X 10(3) s-1. The rate sensitivity itself increases with increasing tungsten content. The rate sensitivity of the alloy with the highest tungsten content (97 pct W) appears to be essentially the same as that of pure polycrystalline tungsten. In addition to showing greater strain hardening, the unswaged alloy also shows a much higher rate dependence than the swaged alloys, with the flow stress almost doubling when the rate of deformation increases from quasistatic to 5 X 10(3) s-1. The rate-hardening mechanism within the composite appears to be essentially that associated with the tungsten grains; however, the matrix contribution is significant in the case of an unswaged alloy. C1 USA,BALLIST RES LAB,ABERDEEN PROVING GROUND,ABERDEEN,MD. RP RAMESH, KT (reprint author), JOHNS HOPKINS UNIV,DEPT MECH ENGN,BALTIMORE,MD 21218, USA. NR 19 TC 65 Z9 70 U1 1 U2 13 PU MINERALS METALS MATERIALS SOC PI WARRENDALE PA 420 COMMONWEALTH DR, WARRENDALE, PA 15086 SN 0360-2133 J9 METALL TRANS A PD SEP PY 1992 VL 23 IS 9 BP 2625 EP 2630 DI 10.1007/BF02658066 PG 6 WC Materials Science, Multidisciplinary SC Materials Science GA JM389 UT WOS:A1992JM38900033 ER PT J AU MILLER, MM AF MILLER, MM TI DEFENSE-DEPARTMENT PURSUIT OF INSURERS FOR SUPERFUND COST RECOVERY SO MILITARY LAW REVIEW LA English DT Article ID POLLUTION EXCLUSION; LIABILITY RP MILLER, MM (reprint author), USA,DIV ENVIRONM LAW,OFF JUDGE ADVOCATE GEN,WASHINGTON,DC 20310, USA. NR 43 TC 1 Z9 1 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD FAL PY 1992 VL 138 BP 1 EP 52 PG 52 WC Law SC Government & Law GA KP006 UT WOS:A1992KP00600001 ER PT J AU WEBSTER, LK AF WEBSTER, LK TI DAVIS V MICHIGAN-DEPARTMENT-OF-TREASURY - THE RETROACTIVITY MORASS IN REFUNDS OF STATE TAXES SO MILITARY LAW REVIEW LA English DT Article RP WEBSTER, LK (reprint author), USA,JUDGE ADVOCATE GEN CORPS,WASHINGTON,DC 20310, USA. NR 16 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD FAL PY 1992 VL 138 BP 127 EP 185 PG 59 WC Law SC Government & Law GA KP006 UT WOS:A1992KP00600003 ER PT J AU SELLEN, KL AF SELLEN, KL TI THE UNITED-NATIONS-SECURITY-COUNCIL VETO IN THE NEW-WORLD ORDER SO MILITARY LAW REVIEW LA English DT Article RP SELLEN, KL (reprint author), USA,DIV CRIMINAL LAW,OFF STAFF JUDGE ADVOCATE,FT GORDON,GA 30905, USA. NR 78 TC 1 Z9 1 U1 1 U2 4 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD FAL PY 1992 VL 138 BP 187 EP 262 PG 76 WC Law SC Government & Law GA KP006 UT WOS:A1992KP00600004 ER PT J AU BORCH, FL AF BORCH, FL TI ARMING MILITARY-JUSTICE - LURIE,J SO MILITARY LAW REVIEW LA English DT Book Review RP BORCH, FL (reprint author), USA,JUDGE ADVOCATE GEN SCH,DIV CRIMINAL LAW,WASHINGTON,DC 20310, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD FAL PY 1992 VL 138 BP 263 EP 265 PG 3 WC Law SC Government & Law GA KP006 UT WOS:A1992KP00600005 ER PT J AU BORCH, FL AF BORCH, FL TI BAND OF BROTHERS - AMBROSE,SE SO MILITARY LAW REVIEW LA English DT Book Review RP BORCH, FL (reprint author), USA,JUDGE ADVOCATE GEN SCH,DIV CRIMINAL LAW,WASHINGTON,DC 20310, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD FAL PY 1992 VL 138 BP 273 EP 275 PG 3 WC Law SC Government & Law GA KP006 UT WOS:A1992KP00600007 ER PT J AU MCHALE, KA CLEMENCE, E CORBETT, D AF MCHALE, KA CLEMENCE, E CORBETT, D TI EFFICIENCY IN THE PEDIATRIC ORTHOPEDIC CLINIC AND THE EFFECT ON THE PARENTS - A COMPARISON OF MILITARY AND CIVILIAN MEDICAL-CENTERS SO MILITARY MEDICINE LA English DT Article AB In a short-term comparison of similar pediatric orthopedic practices at a military and a civilian institution in the same geographical location, it was found that total appointment time, waiting time, and travel time were longer in the military setting. It appeared, however, that there was more leniency toward time off from work to accompany children to appointments in the military population. These factors may have considerable impact on time lost from the job for service member sponsors. RP MCHALE, KA (reprint author), WALTER REED ARMY MED CTR,WASHINGTON,DC 20307, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD SEP PY 1992 VL 157 IS 9 BP 466 EP 467 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA JP041 UT WOS:A1992JP04100009 PM 1454193 ER PT J AU CARAVALHO, J AF CARAVALHO, J TI KNEE PROTECTION DURING RANGER SCHOOL SO MILITARY MEDICINE LA English DT Letter RP CARAVALHO, J (reprint author), USA,75TH RANGER REGIMENT,FT BENNING,GA, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD SEP PY 1992 VL 157 IS 9 BP A3 EP A3 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA JP041 UT WOS:A1992JP04100001 PM 1454186 ER PT J AU KIANG, JG MCCLAIN, DE AF KIANG, JG MCCLAIN, DE TI HSP-72 INDUCTION CAUSED BY HEAT-SHOCK DEPENDS ON AN INCREASE IN [CA2+]I IN HUMAN-A-431 CELLS SO MOLECULAR BIOLOGY OF THE CELL LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,DEPT CLIN PHYSIOL,WASHINGTON,DC 20307. ARMED FORCES RADIOBIOL RES INST,BETHESDA,MD 20889. NR 0 TC 1 Z9 1 U1 0 U2 0 PU AMER SOC CELL BIOLOGY PI BETHESDA PA PUBL OFFICE, 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 1059-1524 J9 MOL BIOL CELL JI Mol. Biol. Cell PD SEP PY 1992 VL 3 SU S BP A249 EP A249 PG 1 WC Cell Biology SC Cell Biology GA JR255 UT WOS:A1992JR25501445 ER PT J AU NATH, J POWLEDGE, A AF NATH, J POWLEDGE, A TI REGULATION OF STIMULUS-RESPONSIVE EXOCYTOSIS IN HUMAN NEUTROPHILS - EFFECTS OF BOTULINUM TOXINS AND BREFELDIN-A SO MOLECULAR BIOLOGY OF THE CELL LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,DEPT HEMATOL ONCOL,WASHINGTON,DC 20307. NR 1 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CELL BIOLOGY PI BETHESDA PA PUBL OFFICE, 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 1059-1524 J9 MOL BIOL CELL JI Mol. Biol. Cell PD SEP PY 1992 VL 3 SU S BP A86 EP A86 PG 1 WC Cell Biology SC Cell Biology GA JR255 UT WOS:A1992JR25500498 ER PT J AU ROTHWELL, SW WRIGHT, DG AF ROTHWELL, SW WRIGHT, DG TI CHARACTERIZATION OF INFLUENZA-A VIRUS BINDING-SITES ON HUMAN NEUTROPHILS SO MOLECULAR BIOLOGY OF THE CELL LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,DEPT HEMATOL ONCOL,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CELL BIOLOGY PI BETHESDA PA PUBL OFFICE, 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 1059-1524 J9 MOL BIOL CELL JI Mol. Biol. Cell PD SEP PY 1992 VL 3 SU S BP A88 EP A88 PG 1 WC Cell Biology SC Cell Biology GA JR255 UT WOS:A1992JR25500511 ER PT J AU SCHWARTZ, GN KESSLER, SW REID, T PERDUE, JF AF SCHWARTZ, GN KESSLER, SW REID, T PERDUE, JF TI IGF-II ENHANCED IL-3-INDUCED ERYTHROPOIESIS AND MYELOPOIESIS IN SUSPENSION-CULTURES OF HUMAN BONE-MARROW CELLS SO MOLECULAR BIOLOGY OF THE CELL LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. AMER RED CROSS,BETHESDA,MD 20814. USN,MED RES INST,BETHESDA,MD 20814. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CELL BIOLOGY PI BETHESDA PA PUBL OFFICE, 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 1059-1524 J9 MOL BIOL CELL JI Mol. Biol. Cell PD SEP PY 1992 VL 3 SU S BP A142 EP A142 PG 1 WC Cell Biology SC Cell Biology GA JR255 UT WOS:A1992JR25500824 ER PT J AU STEIN, MP NOVAK, JM FRIEDLANDER, AM AF STEIN, MP NOVAK, JM FRIEDLANDER, AM TI EFFECT OF ACIDIC PH ON FRAGMENTS OF BACILLUS-ANTHRACIS PROTECTIVE ANTIGEN BOUND TO J774A.1 CELLS SO MOLECULAR BIOLOGY OF THE CELL LA English DT Meeting Abstract C1 USA,MED RES INST INFECT DIS,FREDERICK,MD 21701. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CELL BIOLOGY PI BETHESDA PA PUBL OFFICE, 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 1059-1524 J9 MOL BIOL CELL JI Mol. Biol. Cell PD SEP PY 1992 VL 3 SU S BP A117 EP A117 PG 1 WC Cell Biology SC Cell Biology GA JR255 UT WOS:A1992JR25500676 ER PT J AU WERRLEIN, RJ MADRENWHALLEY, J KIRBY, SD AF WERRLEIN, RJ MADRENWHALLEY, J KIRBY, SD TI PULMONARY EPITHELIA AND F-ACTIN RESPONSE TO PHOSGENE EXPOSURES SO MOLECULAR BIOLOGY OF THE CELL LA English DT Meeting Abstract C1 USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CELL BIOLOGY PI BETHESDA PA PUBL OFFICE, 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 1059-1524 J9 MOL BIOL CELL JI Mol. Biol. Cell PD SEP PY 1992 VL 3 SU S BP A287 EP A287 PG 1 WC Cell Biology SC Cell Biology GA JR255 UT WOS:A1992JR25501664 ER PT J AU WRIGHT, DG KIMMEL, AR AF WRIGHT, DG KIMMEL, AR TI GUANYLATE DEPLETION IS AN EARLY METABOLIC EVENT IN DICTYOSTELIUM DEVELOPMENT TRIGGERED BY NUTRIENT DEPRIVATION SO MOLECULAR BIOLOGY OF THE CELL LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,DEPT HEMATOL,WASHINGTON,DC 20307. NIADDKD,CELLULAR & DEV BIOL LAB,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC CELL BIOLOGY PI BETHESDA PA PUBL OFFICE, 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 1059-1524 J9 MOL BIOL CELL JI Mol. Biol. Cell PD SEP PY 1992 VL 3 SU S BP A109 EP A109 PG 1 WC Cell Biology SC Cell Biology GA JR255 UT WOS:A1992JR25500629 ER PT J AU HOLTZMAN, DM LI, YW PARADA, LF KINSMAN, S CHEN, CK VALLETTA, JS ZHOU, J LONG, JB MOBLEY, WC AF HOLTZMAN, DM LI, YW PARADA, LF KINSMAN, S CHEN, CK VALLETTA, JS ZHOU, J LONG, JB MOBLEY, WC TI P140TRK MESSENGER-RNA MARKS NGF-RESPONSIVE FOREBRAIN NEURONS - EVIDENCE THAT TRK GENE-EXPRESSION IS INDUCED BY NGF SO NEURON LA English DT Article ID NERVE GROWTH-FACTOR; TYROSINE PROTEIN-KINASE; HIGH-AFFINITY RECEPTORS; NEUROTROPHIC FACTOR; CHOLINERGIC NEURONS; BASAL FOREBRAIN; MOLECULAR-CLONING; FACTOR FAMILY; RAT-BRAIN; DEVELOPMENTAL EXPRESSION AB Nerve growth factor (NGF) appears to act as a neurotrophic factor for basal forebrain and caudate-putamen cholinergic neurons. The mechanism by which NGF transduces its signal in these neurons is yet to be defined. Recent data indicate that the product of the trk gene, p140trk, is a critical component of the NGF receptor. Herein, we show that p140trk mRNA is highly restricted in its distribution in the adult rat forebrain, that it is present in cholinergic neurons, and that most if not all cholinergic neurons contain p140trk mRNA. Furthermore, induction of trk expression by NGF suggests that neurotrophin-mediated up-regulation of their receptor tyrosine kinases is an important feature of their actions and that neurotrophins may regulate the activity of responsive neurons through increasing the level of their receptors. C1 UNIV CALIF SAN FRANCISCO,DEPT PEDIAT,SAN FRANCISCO,CA 94143. UNIV CALIF SAN FRANCISCO,NEUROSCI PROGRAM,SAN FRANCISCO,CA 94143. NCI,FREDERICK CANC RES & DEV CTR,BASIC RES PROGRAM,ADV BIOSCI LAB,FREDERICK,MD 21701. JOHNS HOPKINS UNIV,SCH MED,DEPT PEDIAT,BALTIMORE,MD 21205. KENNEDY KRIEGER INST,BALTIMORE,MD 21205. WALTER REED ARMY MED CTR,NEUROPHARMACOL BRANCH,DEPT MED NEUROSCI,WASHINGTON,DC 20307. RP HOLTZMAN, DM (reprint author), UNIV CALIF SAN FRANCISCO,DEPT NEUROL,SAN FRANCISCO,CA 94143, USA. RI Parada, luis/B-9400-2014 FU NIA NIH HHS [AG00445-02, AG10672]; NINDS NIH HHS [NS24054] NR 76 TC 353 Z9 357 U1 0 U2 0 PU CELL PRESS PI CAMBRIDGE PA 1050 MASSACHUSETTES AVE, CIRCULATION DEPT, CAMBRIDGE, MA 02138 SN 0896-6273 J9 NEURON JI Neuron PD SEP PY 1992 VL 9 IS 3 BP 465 EP 478 DI 10.1016/0896-6273(92)90184-F PG 14 WC Neurosciences SC Neurosciences & Neurology GA JM571 UT WOS:A1992JM57100008 PM 1524827 ER PT J AU DECOSTER, MA KOENIG, ML HUNTER, JC TORTELLA, FC AF DECOSTER, MA KOENIG, ML HUNTER, JC TORTELLA, FC TI CALCIUM DYNAMICS IN NEURONS TREATED WITH TOXIC AND NONTOXIC CONCENTRATIONS OF GLUTAMATE SO NEUROREPORT LA English DT Article DE GLUTAMATE TOXICITY; INTRACELLULAR CALCIUM; FLUO-3; NEURONS; CELLULAR IMAGING ID PAROTID ACINAR-CELLS; INOSITOL PHOSPHATES; CA-2+; NEUROTOXICITY; ENTRY; THAPSIGARGIN; DEPENDENCE; SLICES; LINE AB INTRACELLULAR calcium concentration ([Ca2+]i) dynamics were simultaneously monitored in multiple cultured rat neurons loaded with Fluo-3 and continuously stimulated with glutamate (GLU). Three response types were observed: 10 muM GLU caused an initial transient increase in [Ca2+]i; 20 muM a biphasic response characterized by a 150-350 s 'calcium trough' between peaks; and 40 muM an initial sustained increase in [Ca2+]i. Neurons in calcium-free medium treated with 40 muM GLU showed only an initial transient increase in [Ca2+]i, demonstrating the dependence of sustained secondary increases in [Ca2+]i on extracellular calcium sources. We observed synchronized responses of multiple neurons within a given culture well, after GLU treatment, supporting the hypothesis that sustained influx of extracellular calcium may be stimulated by depletion of intracellular calcium and/or the release of endogenous excitatory amino acids. C1 PARKE DAVIS NEUROSCI RES CTR,CAMBRIDGE CB2 2QB,ENGLAND. RP DECOSTER, MA (reprint author), WALTER REED ARMY INST RES,DEPT MED NEUROSCI,WASHINGTON,DC 20307, USA. OI DeCoster, Mark/0000-0002-1716-2028 NR 19 TC 37 Z9 37 U1 0 U2 0 PU RAPID SCIENCE PUBLISHERS PI LONDON PA 2-6 BOUNDARY ROW, LONDON, ENGLAND SE1 8NH SN 0959-4965 J9 NEUROREPORT JI Neuroreport PD SEP PY 1992 VL 3 IS 9 BP 773 EP 776 DI 10.1097/00001756-199209000-00013 PG 4 WC Neurosciences SC Neurosciences & Neurology GA JY018 UT WOS:A1992JY01800013 PM 1358256 ER PT J AU PARKER, M BARNHILL, D TENERIELLO, M OCONNOR, D PARK, R AF PARKER, M BARNHILL, D TENERIELLO, M OCONNOR, D PARK, R TI INTESTINAL INVASION BY A DYSGERMINOMA IN A PATIENT WITH SWYER SYNDROME SO OBSTETRICS AND GYNECOLOGY LA English DT Article ID GERM AB An unusual case is presented of advanced dysgerminoma in a patient with Swyer syndrome, 46,XY pure gonadal dysgenesis. Unexpected regional invasion necessitated bowel resection, total abdominal hysterectomy, and bilateral salpingo-gonadectomy for a complete en bloc excision of the primary tumor mass and the dysgenetic gonads. This report illustrates the possible need for extensive operative resection in patients with Swyer syndrome. C1 WALTER REED ARMY MED CTR,DEPT OBSTET & GYNECOL,GYNECOL ONCOL SERV,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,DEPT OBSTET & GYNECOL,BETHESDA,MD 20814. UNIFORMED SERV UNIV HLTH SCI,DEPT PATHOL,BETHESDA,MD 20814. NR 13 TC 0 Z9 1 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0029-7844 J9 OBSTET GYNECOL JI Obstet. Gynecol. PD SEP PY 1992 VL 80 IS 3 BP 567 EP 569 PN 2 PG 3 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA JJ703 UT WOS:A1992JJ70300037 PM 1495740 ER PT J AU YU, FTS WU, SD RAJAN, S MAYERS, A GREGORY, DA AF YU, FTS WU, SD RAJAN, S MAYERS, A GREGORY, DA TI OPTICAL NOVELTY FILTER WITH PHASE CARRIER SO OPTICS COMMUNICATIONS LA English DT Article AB The use of a phase carrier to perform novelty filtering is proposed and experimentally demonstrated. C1 USA,MISSILE COMMAND,REDSTONE ARSENAL,AL 35898. RP YU, FTS (reprint author), PENN STATE UNIV,DEPT ELECT & COMP ENGN,UNIV PK,PA 16802, USA. NR 4 TC 4 Z9 4 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0030-4018 J9 OPT COMMUN JI Opt. Commun. PD SEP 1 PY 1992 VL 92 IS 4-6 BP 205 EP 208 DI 10.1016/0030-4018(92)90622-X PG 4 WC Optics SC Optics GA JK610 UT WOS:A1992JK61000008 ER PT J AU GOLENDA, CF BURGE, R SCHNEIDER, I AF GOLENDA, CF BURGE, R SCHNEIDER, I TI PLASMODIUM-FALCIPARUM AND P-BERGHEI - DETECTION OF SPOROZOITES AND THE CIRCUMSPOROZOITE PROTEINS IN THE SALIVA OF ANOPHELES-STEPHENSI MOSQUITOS SO PARASITOLOGY RESEARCH LA English DT Article ID TRANSMITTED INVITRO; MALARIA; QUANTITATION; VACCINE AB Sporozoites and free circumsporozoite (CS) protein were stained immunoenzymatically in 1-min saliva samples collected from Anopheles stephensi mosquitoes infected with either Plasmodium berghei or P. falciparum. The number of sporozoites in 1-min saliva-streak samples significantly increased as the salivary gland index rose from 3+ to 4+. For P. berghei-infected mosquitoes from which saliva had been collected before 30 days postfeed, the median sporozoite counts for 3+ and 4+ gland indexes were 4.5 and 116, respectively. For P. falciparum-infected mosquitoes, the median counts obtained in two experiments were 4.5 and 14.5 (3+) and 97 and 107 (4+), respectively. The frequency of sporozoite detection in the saliva of mosquitoes containing <100 salivary-gland sporozoites was low (0.1), whereas that in the saliva of mosquitoes with > 100 sporozoites was high (0.96). In highly infected 4+ P. berghei-infected mosquitoes from which saliva had been collected after 30 days postinfection, both the volume of saliva collected and the median number of sporozoites recovered decreased significantly. C1 WALTER REED ARMY MED CTR,DEPT BIOMETR,WASHINGTON,DC 20307. RP GOLENDA, CF (reprint author), WALTER REED ARMY MED CTR,DEPT ENTOMOL,WASHINGTON,DC 20307, USA. NR 20 TC 15 Z9 15 U1 0 U2 3 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0044-3255 J9 PARASITOL RES JI Parasitol. Res. PD SEP PY 1992 VL 78 IS 7 BP 563 EP 569 DI 10.1007/BF00936453 PG 7 WC Parasitology SC Parasitology GA JQ589 UT WOS:A1992JQ58900006 PM 1438147 ER PT J AU SAMLASKA, CP SAMUELSON, GA FARAN, ME SHPARAGO, NI AF SAMLASKA, CP SAMUELSON, GA FARAN, ME SHPARAGO, NI TI BLISTER BEETLE DERMATOSIS IN HAWAII CAUSED BY THELYPHASSA-APICATA (FAIRMAIRE) SO PEDIATRIC DERMATOLOGY LA English DT Article AB Members of the family Oedemeridae are known as false blister beetles. Although they have a worldwide distribution, oedemerid blister beetle dermatosis has been described only in the Pacific basin and the Caribbean. We report a case of the disorder in the Hawaiian Islands caused by Thelyphassa apicata (Fairmaire). To our knowledge this is the first case report described in that locale, and the first caused by this species. RP SAMLASKA, CP (reprint author), TRIPLER ARMY MED CTR,DERMATOL SERV,HONOLULU,HI 96859, USA. NR 0 TC 3 Z9 3 U1 0 U2 0 PU BLACKWELL SCIENCE INC PI MALDEN PA 350 MAIN ST, MALDEN, MA 02148 SN 0736-8046 J9 PEDIATR DERMATOL JI Pediatr. Dermatol. PD SEP PY 1992 VL 9 IS 3 BP 246 EP 250 DI 10.1111/j.1525-1470.1992.tb00340.x PG 5 WC Dermatology; Pediatrics SC Dermatology; Pediatrics GA JP220 UT WOS:A1992JP22000004 PM 1488373 ER PT J AU WISWELL, TE AF WISWELL, TE TI MECONIUM AND TRACHEAL ASPIRATION - REPLY SO PEDIATRICS LA English DT Letter ID INFANTS; SUCTION RP WISWELL, TE (reprint author), WALTER REED ARMY MED CTR,DEPT PEDIAT,NEWBORN MED SERV,WASHINGTON,DC 20307, USA. NR 12 TC 2 Z9 2 U1 0 U2 0 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD, ELK GROVE VILLAGE, IL 60007-1098 SN 0031-4005 J9 PEDIATRICS JI Pediatrics PD SEP PY 1992 VL 90 IS 3 BP 475 EP 476 PG 2 WC Pediatrics SC Pediatrics GA JM412 UT WOS:A1992JM41200035 ER PT J AU WISWELL, TE AF WISWELL, TE TI MECONIUM ASPIRATION SYNDROME (MAS) - REPLY SO PEDIATRICS LA English DT Letter RP WISWELL, TE (reprint author), WALTER REED ARMY MED CTR,DEPT PEDIAT,NEONATOL SECT,WASHINGTON,DC 20307, USA. NR 2 TC 0 Z9 0 U1 0 U2 0 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD, ELK GROVE VILLAGE, IL 60007-1098 SN 0031-4005 J9 PEDIATRICS JI Pediatrics PD SEP PY 1992 VL 90 IS 3 BP 476 EP 477 PG 2 WC Pediatrics SC Pediatrics GA JM412 UT WOS:A1992JM41200038 ER PT J AU HORNER, R ACKLEY, SF DIECKMANN, GS GULLIKSEN, B HOSHIAI, T LEGENDRE, L MELNIKOV, IA REEBURGH, WS SPINDLER, M SULLIVAN, CW AF HORNER, R ACKLEY, SF DIECKMANN, GS GULLIKSEN, B HOSHIAI, T LEGENDRE, L MELNIKOV, IA REEBURGH, WS SPINDLER, M SULLIVAN, CW TI ECOLOGY OF SEA ICE BIOTA .1. HABITAT, TERMINOLOGY, AND METHODOLOGY SO POLAR BIOLOGY LA English DT Review ID SOUTHEASTERN HUDSON-BAY; MICROBIAL COMMUNITIES; MCMURDO-SOUND; WEDDELL SEA; MICROALGAL COMMUNITY; ALGAL ASSEMBLAGES; EAST-ANTARCTICA; ST-LAWRENCE; FRAZIL ICE; BOTTOM-ICE AB Polar regions are covered by extensive sea ice that is inhabited by a variety of plants and animals. The environments where the organisms live vary depending on the structure and age of the ice. Many terms have been used to describe the habitats and the organisms. We here characterize the habitats and communities and suggest some standard terms for them. We also suggest routine sampling methods and reporting units for measurements of biological and chemical variables. C1 USA,COLD REG RES & ENGN LAB,HANOVER,NH 03755. ALFRED WEGENER INST POLAR & MARINE RES,W-2850 BREMERHAVEN,GERMANY. UNIV TROMSO,N-9001 TROMSO,NORWAY. NATL INST POLAR RES,ITABASHI KU,TOKYO 173,JAPAN. UNIV LAVAL,DEPT BIOL,QUEBEC CITY G1K 7P4,QUEBEC,CANADA. USSR ACAD SCI,INST OCEANOL,MOSCOW 117218,USSR. UNIV ALASKA,INST MARINE SCI,FAIRBANKS,AK 99701. UNIV KIEL,INST POLAROKOL,W-2300 KIEL 1,GERMANY. UNIV SO CALIF,DEPT BIOL SCI,LOS ANGELES,CA 90089. RP HORNER, R (reprint author), UNIV WASHINGTON,SCH OCEANOG,WB-10,SEATTLE,WA 98195, USA. RI Dieckmann, Gerhard/B-4307-2010 NR 110 TC 182 Z9 191 U1 4 U2 32 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0722-4060 J9 POLAR BIOL JI Polar Biol. PD SEP PY 1992 VL 12 IS 3-4 BP 417 EP 427 PG 11 WC Biodiversity Conservation; Ecology SC Biodiversity & Conservation; Environmental Sciences & Ecology GA JP998 UT WOS:A1992JP99800010 ER PT J AU LEGENDRE, L ACKLEY, SF DIECKMANN, GS GULLIKSEN, B HORNER, R HOSHIAI, T MELNIKOV, IA REEBURGH, WS SPINDLER, M SULLIVAN, CW AF LEGENDRE, L ACKLEY, SF DIECKMANN, GS GULLIKSEN, B HORNER, R HOSHIAI, T MELNIKOV, IA REEBURGH, WS SPINDLER, M SULLIVAN, CW TI ECOLOGY OF SEA ICE BIOTA .2. GLOBAL SIGNIFICANCE SO POLAR BIOLOGY LA English DT Review ID SOUTHEASTERN HUDSON-BAY; PHYTOPLANKTON BLOOM DYNAMICS; ATMOSPHERIC CO2 VARIATIONS; ANTARCTIC PACK ICE; WEDDELL-SCOTIA SEA; MICROBIAL COMMUNITIES; BOREOGADUS-SAIDA; MCMURDO-SOUND; ARCTIC-OCEAN; BACTERIAL PRODUCTION AB The sea ice does not only determine the ecology of ice biota, but it also influences the pelagic systems under the ice cover and at ice edges. In this paper, new estimates of Arctic and Antarctic production of biogenic carbon are derived, and differences as well as similarities between the two oceans are examined. In ice-covered seas, high algal concentrations (blooms) occur in association with several types of conditions. Blooms often lead to high sedimentation of intact cells and faecal pellets. In addition to ice-related blooms, there is progressive accumulation of organic matter in Arctic multi-year ice, whose fate may potentially be similar to that of blooms. A fraction of the carbon fixed by microalgae that grow in sea ice or in relation to it is exported out of the production zone. This includes particulate material sinking out of the euphotic zone, and also material passed on to the food web. Pathways through which ice algal production does reach various components of the pelagic and benthic food webs, and through them such top predators as marine mammals and birds, are discussed. Concerning global climate change and biogeochemical fluxes of carbon, not all export pathways from the euphotic zone result in the sequestration of carbon for periods of hundreds of years or more. This is because various processes, that take place in both the ice and the water column, contribute to mineralize organic carbon into CO2 before it becomes sequestered. Processes that favour the production and accumulation of biogenic carbon as well as its export to deep waters and sequestration are discussed, together with those that influence mineralization in the upper ice-covered ocean. C1 USA,COLD REG RES & ENGN LAB,HANOVER,NH 03755. ALFRED WEGENER INST POLAR & MARINE RES,W-2850 BREMERHAVEN,GERMANY. UNIV TROMSO,N-9001 TROMSO,NORWAY. UNIV WASHINGTON,SCH OCEANOG,SEATTLE,WA 98195. NATL INST POLAR RES,ITABASHI KU,TOKYO 173,JAPAN. ACAD SCI,INST OCEANOL,MOSCOW 117218,USSR. UNIV ALASKA,INST MARINE SCI,FAIRBANKS,AK 99701. UNIV KIEL,INST POLAR ECOL,W-2300 KIEL 1,GERMANY. UNIV SO CALIF,DEPT BIOL SCI,LOS ANGELES,CA 90089. RP LEGENDRE, L (reprint author), UNIV LAVAL,DEPT BIOL,QUEBEC CITY G1K 7P4,QUEBEC,CANADA. RI Dieckmann, Gerhard/B-4307-2010 NR 174 TC 260 Z9 280 U1 8 U2 70 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0722-4060 J9 POLAR BIOL JI Polar Biol. PD SEP PY 1992 VL 12 IS 3-4 BP 429 EP 444 PG 16 WC Biodiversity Conservation; Ecology SC Biodiversity & Conservation; Environmental Sciences & Ecology GA JP998 UT WOS:A1992JP99800011 ER PT J AU FRANCIS, T WARTOFSKY, L AF FRANCIS, T WARTOFSKY, L TI COMMON THYROID-DISORDERS IN THE ELDERLY SO POSTGRADUATE MEDICINE LA English DT Article ID L-THYROXINE; DISEASE; HYPOTHYROIDISM; THYROTOXICOSIS; THERAPY AB Thyroid disease in the elderly is common but often has an insidious onset with symptoms that mimic those of normal aging. Understanding the significance of thyroid function test results requires an appreciation of the normal physiologic variations of aging and the complicating effects of diseases and medications; only then can one accurately discriminate between various disease processes, order additional appropriate tests, and deliver rational management. The increasing prevalence of thyroid disorders with age, coupled with the current and future dramatic growth of the elderly population, demands that primary care providers be vigilant to the likelihood of thyroid disease and informed as to its most proper, expedient, and cost-effective diagnosis and management. C1 WALTER REED ARMY MED CTR,DEPT MED,DIV ENDOCRINOL,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. NR 19 TC 9 Z9 9 U1 0 U2 0 PU MCGRAW HILL HEALTHCARE PUBLICATIONS PI MINNEAPOLIS PA 4530 WEST 77TH ST, MINNEAPOLIS, MN 55435-5000 SN 0032-5481 J9 POSTGRAD MED JI Postgrad. Med. PD SEP 1 PY 1992 VL 92 IS 3 BP 225 EP & PG 0 WC Medicine, General & Internal SC General & Internal Medicine GA JM908 UT WOS:A1992JM90800019 PM 1518756 ER PT J AU BROWN, GR RUNDELL, JR MCMANIS, SE KENDALL, SN ZACHARY, R TEMOSHOK, L AF BROWN, GR RUNDELL, JR MCMANIS, SE KENDALL, SN ZACHARY, R TEMOSHOK, L TI PREVALENCE OF PSYCHIATRIC-DISORDERS IN EARLY STAGES OF HIV-INFECTION SO PSYCHOSOMATIC MEDICINE LA English DT Article DE HUMAN IMMUNODEFICIENCY VIRUS; PSYCHIATRY; PREVALENCE; DEPRESSION; SEXUAL DYSFUNCTION; MILITARY ID HUMAN-IMMUNODEFICIENCY-VIRUS; UNITED-STATES; SCREENING-PROGRAM; SEXUAL-ACTIVITY; DRUG-USE; AIDS; MEN; HEALTH; PSYCHOPATHOLOGY; INDIVIDUALS AB As part of a military universal HIV screening program, 442 men were assessed for the presence of DSM-III-R defined psychiatric disorders and symptoms of anxiety and depression after notification of HIV seroconversion. Of them, 84.4% were in the earliest, asymptomatic stages of disease at the time of interview (96% did not have AIDS). The Structured Clinical Interview for DSM-III-R and Structured Interview Guide for the Hamilton Anxiety and Depression Scales were used. Relevant comparisons were made to Epidemiologic Catchment Area prevalence data. HIV seropositive men were more likely than age-matched men in the community to have current diagnoses of major depression (ages 18-44) and anxiety disorders (ages 25-44). Higher lifetime rates of major depression and alcohol use disorder, and high current prevalence of sexual dysfunction (21.7%) were noted. We conclude that men who become HIV seropositive have high rates of mood and substance use disorders prior to knowledge of seroconversion, and that early in the course of HIV infection men are at risk for developing major depression, anxiety disorders, and disorders of sexual desire. C1 WILFORD HALL USAF MED CTR,HENRY M JACKSON FDN,LACKLAND AFB,TX 78236. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. WILFORD HALL USAF MED CTR,DEPT PSYCHIAT,ROCKVILLE,MD. HENRY M JACKSON FDN,ROCKVILLE,MD. NR 42 TC 100 Z9 101 U1 4 U2 5 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0033-3174 J9 PSYCHOSOM MED JI Psychosom. Med. PD SEP-OCT PY 1992 VL 54 IS 5 BP 588 EP 601 PG 14 WC Psychiatry; Psychology; Psychology, Multidisciplinary SC Psychiatry; Psychology GA JP995 UT WOS:A1992JP99500007 PM 1438661 ER PT J AU PHILLIPS, WJ AF PHILLIPS, WJ TI AN ARGUMENT AGAINST THE USE OF THE NERVE STIMULATOR FOR PERIPHERAL-NERVE BLOCKS SO REGIONAL ANESTHESIA LA English DT Letter RP PHILLIPS, WJ (reprint author), WALTER REED ARMY MED CTR,ANESTHESIA & OPERAT SERV,WASHINGTON,DC 20307, USA. NR 0 TC 8 Z9 8 U1 0 U2 0 PU CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS PI NEW YORK PA 650 AVENUE OF THE AMERICAS, NEW YORK, NY 10011 SN 0146-521X J9 REGION ANESTH JI Reg. Anesth. PD SEP-OCT PY 1992 VL 17 IS 5 BP 309 EP 310 PG 2 WC Anesthesiology SC Anesthesiology GA JU422 UT WOS:A1992JU42200014 PM 1419949 ER PT J AU GOERINGER, F AF GOERINGER, F TI AN ELECTRONIC BEACHHEAD IN MEDICAL IMAGING SO SIEMENS REVIEW LA English DT Editorial Material RP GOERINGER, F (reprint author), USA,MED DIAGNOST IMAGING SUPPORT PROGRAM,FREDERICK,MD 21701, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SIEMENS-AKTIENGESELLSCHAFT PI ERLANGEN 2 PA POSTFACH 3240, W-8520 ERLANGEN 2, GERMANY SN 0302-2528 J9 SIEMENS REV JI Siemens Rev. PD SEP-OCT PY 1992 VL 59 IS 5 BP 5 EP & PG 0 WC Engineering, Electrical & Electronic; Instruments & Instrumentation SC Engineering; Instruments & Instrumentation GA JX434 UT WOS:A1992JX43400001 ER PT J AU LANDE, RG AF LANDE, RG TI SUICIDE AND THE MILITARY-JUSTICE SYSTEM SO SUICIDE AND LIFE-THREATENING BEHAVIOR LA English DT Article AB The United States military is sensitive to suicide. There are military policies that direct the formation of active suicide prevention programs. The U.S. military emphasizes a humanitarian approach. Modern military law, however, may view suicidal behavior as deviant. The prosecution of this behavior, although theoretically possible, has never occurred until recently. The U.S. military has now convicted soldiers for attempted suicide and assisted suicide. This article reviews these recent court decisions and suggests revisions in the military law. RP LANDE, RG (reprint author), USA,WALTER REED ARMY MED CTR,DEPT PSYCHIAT,WASHINGTON,DC 20012, USA. NR 5 TC 3 Z9 3 U1 0 U2 0 PU GUILFORD PUBLICATIONS INC PI NEW YORK PA 72 SPRING STREET, NEW YORK, NY 10012 SN 0363-0234 J9 SUICIDE LIFE-THREAT JI Suicide Life-Threat. Behav. PD FAL PY 1992 VL 22 IS 3 BP 341 EP 349 PG 9 WC Psychiatry; Psychology, Multidisciplinary SC Psychiatry; Psychology GA JR105 UT WOS:A1992JR10500006 PM 1440748 ER PT J AU CUNNIFF, PM AF CUNNIFF, PM TI AN ANALYSIS OF THE SYSTEM EFFECTS IN WOVEN FABRICS UNDER BALLISTIC IMPACT SO TEXTILE RESEARCH JOURNAL LA English DT Article AB Following a brief review of prior work on fabric-based armor systems, the system effects that occur during the ballistic impact of woven fabric body armor materials are discussed from a conceptual framework developed to relate single yam impact mechanics to fabric impact mechanics. The consequence of assembling yams into single-ply fabric structures is discussed from this perspective. A steep strain gradient along yams in the region of the transverse deflection of the fabric is related to the constraint imposed on them by neighboring yams. Striking and residual velocity data, collected for single-ply fabric systems of Spectra(R), Kevlar(R) 29, and nylon with various different yam deniers and weave types, are used to establish the response of spaced armor systems. The system effects of assembling fabric plies into body armor systems are determined by comparing the response of spaced armor systems to actual multiple-ply systems. There is a pronounced decrease in energy absorption capacity for the Spectra and nylon systems; this deleterious effect is ascribed to increased transverse stresses and possible interference of the deflection characteristics of fabric plies by subsequent plies. RP CUNNIFF, PM (reprint author), USA,NATICK RES DEV & ENGN CTR,INDIVIDUAL PROTECT DIRECTORATE,NATICK,MA 01760, USA. RI Cunniff, Philip/I-9497-2014 OI Cunniff, Philip/0000-0002-1870-2217 NR 28 TC 168 Z9 179 U1 3 U2 35 PU TEXTILE RESEARCH INST PI PRINCETON PA PO BOX 625, PRINCETON, NJ 08540 SN 0040-5175 J9 TEXT RES J JI Text. Res. J. PD SEP PY 1992 VL 62 IS 9 BP 495 EP 509 PG 15 WC Materials Science, Textiles SC Materials Science GA JL489 UT WOS:A1992JL48900001 ER PT J AU TSENG, YCL BURMAN, KD LAHIRI, S DAVIS, J WARTOFSKY, L AF TSENG, YCL BURMAN, KD LAHIRI, S DAVIS, J WARTOFSKY, L TI THYROTROPIN MODULATION OF EPIDERMAL GROWTH-FACTOR (EGF) BINDING TO RECEPTORS ON CULTURED THYROID-CELLS SO THYROID LA English DT Article ID ATRIAL-NATRIURETIC-PEPTIDE; ADENOSINE-3',5'-MONOPHOSPHATE PRODUCTION; DNA-SYNTHESIS; CYCLIC-AMP; DIFFERENTIATION; MEMBRANES; THYROGLOBULIN; ACCUMULATION; THYROCYTES; TISSUE AB Previous studies had shown that epidermal growth factor (EGF) will stimulate growth of cultured thyroid cells in vitro, and TSH will stimulate total assayable EGF receptor in cultured porcine thyroid cells. In this study, we report the effect of TSH on EGF binding to human thyroid cells. Addition of bTSH (1 mU/mL) in binding buffer during receptor assay stimulated specific EGF binding to cells, with an increase of 44% observed over the control after 1 h incubation at 37-degrees-C. Affinity crosslinking of the [I-125]EGF-receptor complex showed a single labeled band with molecular size of 170 kD. No additional band was detected in the presence of TSH. Preincubation of cells with chloroquine, which inhibits lysosomal degradative enzyme activity, caused a continuous accumulation of bound EGF over a 4 h study period at 37-degrees-C, and TSH stimulated an increase in internalized EGF. In the presence of chloroquine, total specific bound EGF was linearly correlated to incubation time up to 4 h and can be expressed as Bound = slope*time + intercept (time0) Addition of TSH during the binding assay significantly increased the value of the slope when compared to control (p < 0. 002). The rate at which prebound [I-125]EGF was released into medium was not affected by the presence of TSH, indicating that TSH-enhanced binding may not be attributed to a reduction in EGF degradation. Coincubation of thyroid cells with EGF at 0 and 1 ng/mL and increasing concentrations of TSH (0-10 mU/mL) indicated that EGF stimulated thymidine incorporation, although TSH failed to synergistically enhance EGF-stimulated cell growth. We conclude that (a) EGF receptor binding in human thyrocytes is enhanced by TSH, (b) the increase results from an enhanced rate of binding, (c) this increased binding rate is related to stimulation by TSH of receptor mediated internalization, (d) TSH-enhanced EGF binding to receptor was not translated into stimulation of cell growth in this cell culture system. C1 WALTER REED ARMY MED CTR,DEPT MED,ENDOCRINE METAB SERV,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT SURG,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. NR 31 TC 3 Z9 3 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 1050-7256 J9 THYROID JI Thyroid PD FAL PY 1992 VL 2 IS 3 BP 181 EP 187 DI 10.1089/thy.1992.2.181 PG 7 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA JR806 UT WOS:A1992JR80600001 PM 1422229 ER PT J AU WARTOFSKY, L AF WARTOFSKY, L TI CLASSIFICATION OF EYE CHANGES OF GRAVES-DISEASE SO THYROID LA English DT Editorial Material RP WARTOFSKY, L (reprint author), WALTER REED ARMY MED CTR,AMER THYROID ASSOC,WASHINGTON,DC 20307, USA. NR 0 TC 81 Z9 85 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 1050-7256 J9 THYROID JI Thyroid PD FAL PY 1992 VL 2 IS 3 BP 235 EP 236 PG 2 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA JR806 UT WOS:A1992JR80600010 ER PT J AU LIESKE, CN CLARK, JH MAXWELL, DM ZOEFFEL, LD SULTAN, WE AF LIESKE, CN CLARK, JH MAXWELL, DM ZOEFFEL, LD SULTAN, WE TI STUDIES OF THE AMPLIFICATION OF CARBARYL TOXICITY BY VARIOUS OXIMES SO TOXICOLOGY LETTERS LA English DT Article DE CARBARYL; OXIMES; ACETYLCHOLINESTERASE; HUMAN SERUM CHOLINESTERASE ID CARBAMYLATED ACETYLCHOLINESTERASE; DECARBAMYLATION; REACTIVATION; PH AB The administration of 2-pyridine aldoxime methyl chloride (2-PAM Cl) is a standard part of the regimen for treatment of human overexposure to many organophosphorus pesticides and nerve agents. However, some literature references indicate that poisoning by carbaryl (1-naphthyl N-methyl carbamate), an insecticide in everyday use, is aggravated by the administration of 2-PAM Cl. This effect has been reported in the mouse, rat, dog and man. We have found that the inhibition of both eel acetylcholinesterase (eel AChE, EC 3.1.1.7) and human serum cholinesterase (human BuChE, EC 3.1.1.8) by carbaryl was enhanced by several oximes. Based on 95% confidence limits the rank order of potentiation with eel AChE was TMB-4 = Toxogonin > HS-6 = HI-6 > 2-PAM Cl. By the same criterion, the rank order of potentiation with human BuChE was TMB-4 > Toxogonin > HS-6 = 2-PAM Cl. Carbaryl-challenged mice also reflected a potentiation since TMB-4 exacerbated the toxicity more than 2-PAM Cl. Our hypothesis is that certain oximes act as allosteric effectors of cholinesterases in carbaryl poisoning, resulting in enhanced inhibition rates and potentiation of carbaryl toxicity. RP LIESKE, CN (reprint author), USA,MED RES INST CHEM DEF,APPL PHARMACOL BRANCH,ABERDEEN PROVING GROUND,MD 21010, USA. NR 34 TC 22 Z9 22 U1 2 U2 2 PU ELSEVIER SCI IRELAND LTD PI CLARE PA CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE, IRELAND SN 0378-4274 J9 TOXICOL LETT JI Toxicol. Lett. PD SEP PY 1992 VL 62 IS 2-3 BP 127 EP 137 DI 10.1016/0378-4274(92)90016-D PG 11 WC Toxicology SC Toxicology GA JQ695 UT WOS:A1992JQ69500002 PM 1412499 ER PT J AU MARTIN, JV KOENIG, ML MCCLURE, WO AF MARTIN, JV KOENIG, ML MCCLURE, WO TI PURIFICATION AND CHARACTERIZATION OF IOTROCHOTIN, A NOVEL TOXIN FROM THE CARIBBEAN SPONGE IOTROCHOTA-BIROTULATA, WHICH SELECTIVELY PERMEABILIZES SYNAPTOSOMES SO TOXICON LA English DT Article ID MEDULLARY CHROMAFFIN CELLS; SECRETION; RELEASE; NEUROTRANSMITTERS; BRAIN AB A protein termed iotrochotin (IOT) was isolated from the exudate of the Caribbean sponge Iotrochota birotulata using as an assay its stimulation of the release of radioactivity from synaptosomes preloaded with [H-3]choline. Sephadex G-50 chromatography of the exudate produced one peak, with a mol. wt of approximately 18,000, which was further resolved into two active fractions by anion exchange chromatography. The more tightly bound of the two fractions was characterized and referred to as IOT. The action of IOT was essentially complete by 0.5-1.0 min and was independent of the Ca2+ or Na+ content of the incubation mixture. Released radioactivity included about 50% each of [H-3]acetylcholine and [H-3]choline. Release of radioactivity increased as a function of IOT concentration and then reached a maximum. Extrapolated asymptotic release was nearly equal to that obtained by lysing the synaptosomes. IOT also released radioactivity from synaptosomes which had been preincubated with other tritiated neurotransmitters or with 2-[H-3]deoxy-D-glucose. Lactate dehydrogenase and choline acetyltransferase activities were not released from synaptosomes by treatment with IOT, but were released by digitonin. IOT therefore releases some of the smaller molecular weight components of synaptosomes, but does not permeabilize the synaptosomal membrane in the same way as digitonin treatment. C1 WALTER REED ARMY MED CTR,DEPT MED NEUROSCI,WASHINGTON,DC 20307. UNIV SO CALIF,DEPT BIOL SCI,NEUROBIOL PROGRAM,LOS ANGELES,CA 90089. RP MARTIN, JV (reprint author), RUTGERS STATE UNIV,DEPT BIOL,CAMDEN,NJ 08102, USA. FU NINDS NIH HHS [NS 21339] NR 22 TC 7 Z9 7 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0041-0101 J9 TOXICON JI Toxicon PD SEP PY 1992 VL 30 IS 9 BP 1001 EP 1010 DI 10.1016/0041-0101(92)90044-6 PG 10 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA JN464 UT WOS:A1992JN46400005 PM 1359679 ER PT J AU SCHMIDT, JJ WEINSTEIN, SA SMITH, LA AF SCHMIDT, JJ WEINSTEIN, SA SMITH, LA TI MOLECULAR-PROPERTIES AND STRUCTURE-FUNCTION-RELATIONSHIPS OF LETHAL PEPTIDES FROM VENOM OF WAGLER PIT VIPER, TRIMERESURUS-WAGLERI SO TOXICON LA English DT Article ID SEQUENCES AB Two new lethal peptides (waglerins) were purified from the venom of Trimeresurus wagleri, and sequenced. We found them to be analogs of lethal peptides (waglerins) I and II reported previously (WEINSTEIN et al., Toxicon 29, 227-236, 1991), with an additional Ser-Leu on the amino terminus. Three of the four waglerins were synthesized and the products were chemically and biologically equivalent to the naturally occurring counterparts in venom. Murine i.p. LD50 for synthetic waglerins I, SL-I and II were 0.33, 0.22, and 0.51 mg/kg, respectively. The single, intramolecular disulfide bond in each synthetic peptide formed rapidly in high yield. The reduced (cysteine-containing) forms of the peptides appeared to have significant toxicities, even without prior disulfide bond formation, but synthetic analogs with serine substituted for cysteine were not toxic. The synthetic dimer of waglerin I, formed by two intermolecular disulfide bonds, was not toxic, but rapidly rearranged to lethal, monomeric waglerin I at alkaline pH upon the addition of 5 mM beta-mercaptoethanol. Waglerin I was inactivated by cleavage at Tyr-15 with chymotrypsin. RP SCHMIDT, JJ (reprint author), USA,MED RES INST INFECT DIS,DIV PATHOPHYSIOL,FT DETRICK,FREDERICK,MD 21702, USA. NR 12 TC 24 Z9 26 U1 0 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0041-0101 J9 TOXICON JI Toxicon PD SEP PY 1992 VL 30 IS 9 BP 1027 EP 1036 DI 10.1016/0041-0101(92)90047-9 PG 10 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA JN464 UT WOS:A1992JN46400008 PM 1440639 ER PT J AU SLINEY, DH AF SLINEY, DH TI A SAFETY MANAGERS GUIDE TO THE NEW WELDING EYE FILTERS SO WELDING JOURNAL LA English DT Article RP SLINEY, DH (reprint author), USA,ENVIRONM HYG AGCY,DIV LASER MICROWAVE,ABERDEEN PROVING GROUND,MD 21010, USA. NR 4 TC 2 Z9 2 U1 0 U2 0 PU AMER WELDING SOC PI MIAMI PA PO BOX 351040, MIAMI, FL 33135 SN 0043-2296 J9 WELD J JI Weld. J. PD SEP PY 1992 VL 71 IS 9 BP 45 EP 47 PG 3 WC Metallurgy & Metallurgical Engineering SC Metallurgy & Metallurgical Engineering GA JL481 UT WOS:A1992JL48100005 ER PT J AU BUEHLER, DA CHANDLER, SK MERSMANN, TJ FRASER, JD SEEGAR, JKD AF BUEHLER, DA CHANDLER, SK MERSMANN, TJ FRASER, JD SEEGAR, JKD TI NONBREEDING BALD EAGLE PERCH HABITAT ON THE NORTHERN CHESAPEAKE BAY SO WILSON BULLETIN LA English DT Note ID NEST SITE SELECTION; OREGON; ROOSTS C1 VIRGINIA POLYTECH INST & STATE UNIV,DEPT FISHERIES & WILDLIFE SCI,BLACKSBURG,VA 24061. USA,CTR CHEM RES DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010. NR 17 TC 3 Z9 3 U1 1 U2 3 PU WILSON ORNITHOLOGICAL SOC PI ANN ARBOR PA MUSEUM OF ZOOLOGY UNIV MICHIGAN, ANN ARBOR, MI 48109 SN 0043-5643 J9 WILSON BULL JI Wilson Bull. PD SEP PY 1992 VL 104 IS 3 BP 540 EP 545 PG 6 WC Ornithology SC Zoology GA JQ029 UT WOS:A1992JQ02900016 ER PT J AU BELLAMY, RF AF BELLAMY, RF TI THE MEDICAL EFFECTS OF CONVENTIONAL WEAPONS SO WORLD JOURNAL OF SURGERY LA English DT Article ID CASUALTY AB The medical effects of weapons used in modern conventional warfare are, overwhelmingly, penetrating. Fragments from explosive munitions such as shells, rockets, and grenades are the predominate source of missiles, especially in high-intensity war. Bullets from assault rifles and machine guns cause fewer casualties, except in counterinsurgency operations. The threat from penetrating missiles depends upon the part of the body that is struck and, to a lesser extent, upon the physical characteristics of the missile. The missile's mass and velocity determine its potential to do physical damage, but the extent to which this potential is realized depends upon diverse factors such as shape, construction, and stability. The American experience in the wars of this century indicate that approximately 20 %-25 % of all casualties died on the battlefield and are therefore classified as killed in action. Approximately 3%-5% die while receiving care, and thus are classified as died of wounds. Wounds of the brain or heart and great vessels are the most common causes of death. Prevention of sepsis in soft-tissue and orthopedic wounds is the major medical treatment problem in survivors. Since it determines the quality and quantity of combat casualty care, the single most important factor determining mortality or morbidity for combat casualties is the tactical situation. RP BELLAMY, RF (reprint author), WALTER REED ARMY MED CTR,WASHINGTON,DC 20307, USA. NR 4 TC 29 Z9 30 U1 2 U2 4 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0364-2313 J9 WORLD J SURG JI World J.Surg. PD SEP-OCT PY 1992 VL 16 IS 5 BP 888 EP 892 PG 5 WC Surgery SC Surgery GA JN820 UT WOS:A1992JN82000015 PM 1462625 ER PT J AU NOVAK, JM STEIN, MP LITTLE, SF LEPPLA, SH FRIEDLANDER, AM AF NOVAK, JM STEIN, MP LITTLE, SF LEPPLA, SH FRIEDLANDER, AM TI FUNCTIONAL-CHARACTERIZATION OF PROTEASE-TREATED BACILLUS-ANTHRACIS PROTECTIVE ANTIGEN SO JOURNAL OF BIOLOGICAL CHEMISTRY LA English DT Article ID PSEUDOMONAS EXOTOXIN; ADENYLATE-CYCLASE; DIPHTHERIA-TOXIN; LETHAL TOXIN; EUKARYOTIC CELLS; RECEPTOR-BINDING; LOW PH; ENTRY; PURIFICATION; ENDOCYTOSIS AB Characterization of the functional domains of Bacillus anthracis protective antigen (PA, 83-kDa), the common cellular binding molecule for both anthrax edema toxin and anthrax lethal toxin, is important for understanding the mechanism of entry and action of the anthrax toxins. In this study, we generated both biologically active (facilitates killing of J774A.1 cells in combination with lethal factor, LF) and inactive preparations of PA by protease treatment. Limited proteolytic digestion of PA in vitro with trypsin generated a 20-kDa fragment and a biologically active 63-kDa fragment. In contrast, limited digestion of PA with chymotrypsin yielded a preparation containing 37- and 47-kDa fragments defective for biological activity. Treatment with both chymotrypsin and trypsin generated three major fragments, 20, "17," and 47 kDa as determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. This PA preparation was also biologically inactive. To investigate the nature of the defect resulting from chymotrypsin treatment, we assayed PA preparations for the ability to bind to the cellular receptor and to bind and internalize I-125-LF. All radiolabeled PA preparations bound with specificity to J774A.1 cells and exhibited affinities similar to native 83-kDa PA. Once bound to the cell surface receptor, both trypsin-treated PA and chymotrypsin/trypsin-treated PA specifically bound I-125-LF with high affinity. Finally, these PA preparations delivered I-125-LF to a Pronase-resistant cellular compartment in a time- and temperature-dependent fashion. Thus, the biological defect exhibited by chymotrypsin-treated PA is not at the level of cell binding or internalization but at a step later, such as toxin routing or processing by J774A.1 cells. These protease-treated preparations of PA should prove useful in both elucidating the intracellular processing of anthrax lethal toxin and determining the structure-function relationship of PA and LF. C1 NIDR, MICROBIAL ECOL LAB, BETHESDA, MD 20892 USA. RP USA, MED RES INST INFECT DIS, DIV BACTERIOL, FT DETRICK, FREDERICK, MD 21702 USA. NR 40 TC 55 Z9 55 U1 0 U2 3 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA SN 0021-9258 EI 1083-351X J9 J BIOL CHEM JI J. Biol. Chem. PD AUG 25 PY 1992 VL 267 IS 24 BP 17186 EP 17193 PG 8 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA JL053 UT WOS:A1992JL05300071 PM 1512256 ER PT J AU JAYASURIYA, K DAMAVARAPU, R SLAGG, N AF JAYASURIYA, K DAMAVARAPU, R SLAGG, N TI SELECTIVE CYCLODIMERIZATION OF ACETYLENE AND RELATED MOLECULES - A COMPUTATIONAL APPROACH SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,RDEC,PICATINNY ARSENAL,NJ 07806. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 23 PY 1992 VL 204 BP 15 EP COMP PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA JJ312 UT WOS:A1992JJ31201238 ER PT J AU LOWREY, AH FAMINI, GR AF LOWREY, AH FAMINI, GR TI THEORETICAL DESCRIPTORS FOR THE POTENCY OF SUBSTITUTED COCAINE SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,CRDEC,ABERDEEN PROVING GROUND,MD 21010. USN,RES LAB,STRUCT MATTER LAB,WASHINGTON,DC 20375. NR 6 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 23 PY 1992 VL 204 BP 18 EP COMP PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA JJ312 UT WOS:A1992JJ31201241 ER PT J AU RAMAMURTHY, AC LORENZEN, WI RAJENDRAN, AM GROVE, D AF RAMAMURTHY, AC LORENZEN, WI RAJENDRAN, AM GROVE, D TI STRESS-ANALYSIS OF MULTILAYER PAINTED STEEL DUE TO STONE IMPACT - A NUMERICAL-SIMULATION SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 BASF,SOUTHFIELD,MI 48086. USA,MAT LAB,WATERTOWN,MA 02172. UNIV DAYTON,RES INST,DAYTON,OH 45469. RI Rajendran, Arunachalam/A-1615-2010 NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 23 PY 1992 VL 204 BP 22 EP PMSE PN 2 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA JJ313 UT WOS:A1992JJ31300975 ER PT J AU LIESKE, CN CLARK, JH MAXWELL, DM ZOEFFEL, LD AF LIESKE, CN CLARK, JH MAXWELL, DM ZOEFFEL, LD TI INHIBITION OF HORSE SERUM BUTYRYLCHOLINESTERASE BY THE 4-NITROPHENYL ESTERS OF MONOCHLOROMETHYL(PHENYL)PHOSPHINIC DICHLOROMETHYL(PHENYL)PHOSPHINIC AND TRICHLOROMETHYL-(PHENYL)PHOSPHINIC ACID SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,MRICD,ABERDEEN PROVING GROUND,MD 21010. NR 1 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 23 PY 1992 VL 204 BP 27 EP AGRO PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA JJ312 UT WOS:A1992JJ31200262 ER PT J AU RATTO, JA CHEN, CC KIM, DY BLUMSTEIN, RB AF RATTO, JA CHEN, CC KIM, DY BLUMSTEIN, RB TI INVESTIGATION OF THE PHASE-BEHAVIOR FOR CHITOSAN POLYAMIDE BLENDS SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 UNIV MASSACHUSETTS,DEPT CHEM,POLYMER PROGRAM,LOWELL,MA 01854. USA,NATICK RES & DEV LABS,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 23 PY 1992 VL 204 BP 37 EP CELL PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA JJ312 UT WOS:A1992JJ31200712 ER PT J AU URBAN, JJ FAMINI, GR AF URBAN, JJ FAMINI, GR TI ATOMIC CHARGES IN MOLECULAR MECHANICS FORCE-FIELDS - THE DEPENDENCE OF ELECTROSTATIC POTENTIAL DERIVED CHARGES FOR DOPAMINE ON CONFORMATION SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,CTR CHEM RES DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 23 PY 1992 VL 204 BP 47 EP COMP PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA JJ312 UT WOS:A1992JJ31201270 ER PT J AU ALLEN, AL BALL, DH AF ALLEN, AL BALL, DH TI CONTINUOUS CULTIVATION OF H-MEDITERRANEI FOR THE PRODUCTION OF POLYHYDROXYALKANOATES SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,NATICK RES & DEV LABS,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 23 PY 1992 VL 204 BP 74 EP PMSE PN 2 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA JJ313 UT WOS:A1992JJ31301027 ER PT J AU TAYLOR, CW AF TAYLOR, CW TI CREATING STRATEGIC VISIONS SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,WAR COLL,CARLISLE,PA 17013. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 23 PY 1992 VL 204 BP 87 EP ENVR PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA JJ312 UT WOS:A1992JJ31201369 ER PT J AU HONG, SH SHUELY, WJ AF HONG, SH SHUELY, WJ TI INFLUENCE OF TRACE ADDITIVES AND IMPURITIES ON THE VISCOELASTIC PROPERTIES OF A POLYMER-SOLUTION SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,CHEM RES,RES DIRECTORATE,CTR DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 23 PY 1992 VL 204 BP 97 EP POLY PN 2 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA JJ313 UT WOS:A1992JJ31301309 ER PT J AU ANIS, NA ELDEFRAWI, ME ROGERS, KR THOMPSON, R VALDES, JJ AF ANIS, NA ELDEFRAWI, ME ROGERS, KR THOMPSON, R VALDES, JJ TI A BIOSENSOR FOR MONITORING BLOOD CHOLINESTERASE AS A BIOMARKER OF EXPOSURE TO ORGANOPHOSPHORUS ANTICHOLINESTERASE PESTICIDES SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 UNIV MARYLAND,SCH MED,DEPT PHARMACOL & EXPTL THERAPEUT,BALTIMORE,MD 21201. USA,CTR RES DEV & ENGN,DIV BIOTECHNOL,EDGEWOOD,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 23 PY 1992 VL 204 BP 131 EP AGRO PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA JJ312 UT WOS:A1992JJ31200366 ER PT J AU STIEFEL, J BLACKMAN, M AF STIEFEL, J BLACKMAN, M TI TEACHING BIOCHEMISTRY BY THE THAYER METHOD SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 US MIL ACAD,DEPT CHEM,W POINT,NY 10996. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 23 PY 1992 VL 204 BP 135 EP CHED PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA JJ312 UT WOS:A1992JJ31200965 ER PT J AU STIEFEL, J BLACKMAN, M AF STIEFEL, J BLACKMAN, M TI TEACHING METABOLISM SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 US MIL ACAD,DEPT CHEM,W POINT,NY 10996. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 23 PY 1992 VL 204 BP 146 EP CHED PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA JJ312 UT WOS:A1992JJ31200976 ER PT J AU LOWE, JR TAYLOR, CE CHATMON, SC AF LOWE, JR TAYLOR, CE CHATMON, SC TI DNA-SEQUENCE ANALYSIS IN THE PUTATIVE TRANSCRIPTION TERMINATOR REGION OF THE BACILLUS-ANTHRACIS LEF LOCUS SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,MED RES INST INFECT DIS,DIV BACTERIOL,FREDERICK,MD 21702. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 23 PY 1992 VL 204 BP 152 EP MEDI PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA JJ312 UT WOS:A1992JJ31202510 ER PT J AU FAMINI, GR DEVITO, SC AF FAMINI, GR DEVITO, SC TI USING THEORETICAL DESCRIPTORS IN STRUCTURE-ACTIVITY-RELATIONSHIPS - CYTOCHROME-P450 MEDIATED ACUTE NITRILE TOXICITY SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,CTR DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010. US EPA,OFF POLLUT PREVENT & TOX,WASHINGTON,DC 20460. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 23 PY 1992 VL 204 BP 161 EP AGRO PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA JJ312 UT WOS:A1992JJ31200396 ER PT J AU MCCASSIE, JE MAYER, JM STOTE, RE SHUPE, AE STENHOUSE, PJ DELL, PA KAPLAN, DL AF MCCASSIE, JE MAYER, JM STOTE, RE SHUPE, AE STENHOUSE, PJ DELL, PA KAPLAN, DL TI CURRENT METHODS FOR DETERMINING BIODEGRADATION OF MATERIALS SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,NATICK RES DEV & ENGN CTR,DIV BIOTECHNOL,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 23 PY 1992 VL 204 BP 184 EP PMSE PN 2 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA JJ313 UT WOS:A1992JJ31301137 ER PT J AU CHEN, MF VEZZOLI, GC BURKE, T AF CHEN, MF VEZZOLI, GC BURKE, T TI METHODOLOGY AND EFFECT OF SUBSTITUTION OF GD, GA, AND SB INTO HIGH-TC CERAMIC SUPERCONDUCTORS SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,MAT TECHNOL LAB,WATERTOWN,MA 02172. USA,PULSED POWER LAB,FT MONMOUTH,NJ 07703. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 23 PY 1992 VL 204 BP 261 EP INOR PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA JJ312 UT WOS:A1992JJ31202112 ER PT J AU SCHNEIDER, NS ILLINGER, JL KARASZ, FE AF SCHNEIDER, NS ILLINGER, JL KARASZ, FE TI THE INTERACTION OF WATER WITH POLYURETHANES CONTAINING BLOCK COPOLYMER SOFT SEGMENTS SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,MAT TECHNOL LAB,WATERTOWN,MA 02172. UNIV MASSACHUSETTS,DEPT POLYMER SCI & ENGN,AMHERST,MA 01003. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 23 PY 1992 VL 204 BP 274 EP POLY PN 2 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA JJ313 UT WOS:A1992JJ31301470 ER PT J AU STENHOUSE, PJ MAYER, JM HEPFINGER, MJ COSTA, EA KAPLAN, DL AF STENHOUSE, PJ MAYER, JM HEPFINGER, MJ COSTA, EA KAPLAN, DL TI BLOWN FILM FROM STARCH POLY(VINYL ALCOHOL) AND STARCH ETHYLENE-VINYL ALCOHOL BLENDS SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,NATICK RD&E CTR,DIV BIOTECHNOL,NATICK,MA 01760. USA,NATICK RD&E CTR,DIV MAT RES & ENGN,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD AUG 23 PY 1992 VL 204 BP 325 EP POLY PN 2 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA JJ313 UT WOS:A1992JJ31301521 ER PT J AU GABRIELSEN, B PHELAN, MJ BARTHELROSA, L SEE, C HUGGINS, JW KEFAUVER, DF MONATH, TP USSERY, MA CHMURNY, GN SCHUBERT, EM UPADHYA, K KWONG, C CARTER, DA SECRIST, JA KIRSI, JJ SHANNON, WM SIDWELL, RW KINI, GD ROBINS, RK AF GABRIELSEN, B PHELAN, MJ BARTHELROSA, L SEE, C HUGGINS, JW KEFAUVER, DF MONATH, TP USSERY, MA CHMURNY, GN SCHUBERT, EM UPADHYA, K KWONG, C CARTER, DA SECRIST, JA KIRSI, JJ SHANNON, WM SIDWELL, RW KINI, GD ROBINS, RK TI SYNTHESIS AND ANTIVIRAL EVALUATION OF N-CARBOXAMIDINE-SUBSTITUTED ANALOGS OF 1-BETA-D-RIBOFURANOSYL-1,2,4-TRIAZOLE-3-CARBOXAMIDINE HYDROCHLORIDE SO JOURNAL OF MEDICINAL CHEMISTRY LA English DT Article ID PARAINFLUENZA TYPE-3 VIRUSES; TISSUE-CULTURE; ANTITUMOR-ACTIVITY; COTTON RATS; RIBAVIRIN; DERIVATIVES; SELENAZOFURIN; NUCLEOSIDES; TIAZOFURIN; TOXICITY AB Ten, hitherto unreported, analogues of 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamidine hydrochloride (2a, ribamidine) and methyl carboximidate 5 have been synthesized. These include the N-cyano (2b), N-alkyl (2c-e), N-amino acid (2f-h), NN'-disubstituted (6, 7a,b), and the N-methylated carboxamide (1f) analogues of ribavirin. In addition, a new facile synthesis of carboxamidine 2a was also developed. All compounds were evaluated for biological activity against the following RNA viruses: Punta Toro (PT) and sandfly fever (SF) viruses (bunyaviruses); Japanese encephalitis (JE), yellow fever (YF), and dengue-4 viruses (flaviviruses); parainfluenza type 3 (PIV3), respiratory syncytial virus (RSV), and measles viruses (paramyxoviruses); influenza A and influenza B viruses (orthomyxoviruses); Venezuelan equine encephalomyelitis virus (VEE, alphavirus); human immunodeficiency virus type-1 (HIV-1, lentivirus); the DNA-containing vaccinia (VV) virus (poxvirus); and adeno type 5 (Ad5) viruses. All of the compounds except for 2b and 7a,b exhibited activity against the bunyaviruses such as that observed with 2a; however, higher IC50 values were generally observed. Glycine analogue 2f showed activity in PT-virus-infected mice in terms of increased survivors and decreased markers of viral pathogenicity. Carboxamidine 2a, carboximidate 5, and dimethyl amidine 6 exhibited activity against dengue type-4 virus. Monomethyl amidine 2c demonstrated activity against RSV, PIV3, and, to a lesser extent, influenza A and B. Activity of 2c generally required higher IC50 values than unsubstituted 2a. The latter exhibited hitherto unreported activity against RSV; therapeutic indices for 2a against RSV and PIV3 were >64 and >21. No substantial in vitro activity was observed for any of the compounds tested against Ad5, measles, JE, YF, VEE, or HIV-1. In addition, evidence is presented which argues in favor of a distinct antiviral mechanism of action for carboxamidines, e.g. 6, in contrast to a role as a carboxamide precursor. C1 USA,MED RES INST INFECT DIS,FREDERICK,MD 21701. US FDA,ROCKVILLE,MD 20855. UNIV NEVADA,DEPT CHEM,RENO,NV 89557. PHARM ECO LABS INC,SIMI VALLEY,CA 93065. SO RES INST,BIRMINGHAM,AL 35255. UTAH STATE UNIV,DEPT ANIM DAIRY & VET SCI,LOGAN,UT 84322. BAXTER DIAGNOST INC,DIV MICROSCAN,SACRAMENTO,CA 95691. UNIV CALIF SAN DIEGO,SCH MED,DEPT PHARMACOL,LA JOLLA,CA 92093. RP GABRIELSEN, B (reprint author), NCL,FREDERICK CANC RES FACIL,FREDERICK CANC RES & DEV CTR,PROGRAM RESOURCES INC,POB B,BLDG 427,FREDERICK,MD 21702, USA. FU NCI NIH HHS [N01-CO-74102] NR 32 TC 35 Z9 36 U1 10 U2 16 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0022-2623 J9 J MED CHEM JI J. Med. Chem. PD AUG 21 PY 1992 VL 35 IS 17 BP 3231 EP 3238 DI 10.1021/jm00095a020 PG 8 WC Chemistry, Medicinal SC Pharmacology & Pharmacy GA JK324 UT WOS:A1992JK32400020 PM 1507208 ER PT J AU ROSEN, JM BODHAINE, BA BOATMAN, JF DELUISI, JJ POST, MJ KIM, Y SCHNELL, RC SHERIDAN, PJ GARVEY, DM AF ROSEN, JM BODHAINE, BA BOATMAN, JF DELUISI, JJ POST, MJ KIM, Y SCHNELL, RC SHERIDAN, PJ GARVEY, DM TI MEASURED AND CALCULATED OPTICAL PROPERTY PROFILES IN THE MIXED LAYER AND FREE TROPOSPHERE SO JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES LA English DT Article ID SPECTROMETER PROBE; RESPONSE CHARACTERISTICS; AEROSOL; LIDAR; CALIBRATION; BACKSCATTER; INSTRUMENT AB Nearly simultaneous measurements of the physical and optical properties of mixed layer and free tropospheric aerosols near Boulder, Colorado, were made on several occasions using aircraft, balloon, and ground-based sensors. This effort (Front Range Lidar, Aircraft, and Balloon experiment (FRLAB)) was conducted with the purpose of obtaining a diverse, self-consistent data set that could be used for testing optical model calculations based on measured physical characteristics such as apparent size distribution, composition, and shape. It was found that even with the uncertainties involved, the model predictions are in good agreement with the measurements in the visible and near infrared wavelength regions. At CO2 lidar wavelengths there is considerably more uncertainty in both the calculated and measured values; however, within the estimated errors there appears to be satisfactory agreement except for the highest free tropospheric layer studied. The results also indicate that during FRLAB the aerosol in the boundary layer and free troposphere behaved as spherical particles for optical modeling purposes. The utility of the observations for determining the extinction-to-backscatter ratio relevant to aerosols in the boundary layer and free troposphere is described with typical measured values being in the 20 to 30 sr range. C1 UNIV COLORADO,COOPERAT INST RES ENVIRONM SCI,BOULDER,CO 80303. USA,ATMOSPHER SCI LAB,WHITE SANDS MISSILE RANGE,NM 88002. NOAA,BOULDER,CO 80303. RP ROSEN, JM (reprint author), UNIV WYOMING,DEPT PHYS & ASTRON,LARAMIE,WY 82071, USA. NR 25 TC 17 Z9 17 U1 2 U2 2 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 SN 0148-0227 J9 J GEOPHYS RES-ATMOS JI J. Geophys. Res.-Atmos. PD AUG 20 PY 1992 VL 97 IS D12 BP 12837 EP 12850 PG 14 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA JL282 UT WOS:A1992JL28200005 ER PT J AU MATHER, B AF MATHER, B TI DAM FACTS SO NATURE LA English DT Letter RP MATHER, B (reprint author), USA,CORPS ENGINEERS,WATERWAYS EXPT STN,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 1 TC 0 Z9 0 U1 0 U2 1 PU MACMILLAN MAGAZINES LTD PI LONDON PA PORTERS SOUTH, 4 CRINAN ST, LONDON, ENGLAND N1 9XW SN 0028-0836 J9 NATURE JI Nature PD AUG 20 PY 1992 VL 358 IS 6388 BP 618 EP 618 DI 10.1038/358618e0 PG 1 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA JJ882 UT WOS:A1992JJ88200025 ER PT J AU HALL, DP AF HALL, DP TI A WIDOWS GRIEF - THE LANGUAGE OF THE HEART SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Letter RP HALL, DP (reprint author), WALTER REED ARMY MED CTR,WASHINGTON,DC 20307, USA. NR 4 TC 0 Z9 0 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD AUG 19 PY 1992 VL 268 IS 7 BP 871 EP 872 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA JH588 UT WOS:A1992JH58800025 PM 1640606 ER EF