FN Thomson Reuters Web of Science™ VR 1.0 PT J AU GANS, HD WOODMANSEE, PR AF GANS, HD WOODMANSEE, PR TI AN IMPROVED METHOD OF MODELING POROUS MATERIALS USING FINITE-ELEMENTS SO COMPUTERS & STRUCTURES LA English DT Article ID VOID NUCLEATION; SOLID-SOLUTIONS; GROWTH AB In this paper, a new method for determining the modulus of elasticity of a porous material is developed. This method involves the creation of a finite element model of a specimen of the material. The modulus of elasticity can then be found using limited information from one material sample. The model is three-dimensional, and simulates pores by placing small elements that are non-load bearing into the structure. These voids are randomly and unevenly distributed using a Poisson distribution to better simulate the response of a real porous material to a load. The same finite element model is used to demonstrate the effects on material behavior of changing the pore size and distribution. From this information a trend was noticed and an empirical equation developed that predicts a material's elastic modulus based on porosity and pore size. RP GANS, HD (reprint author), USA,INST TECHNOL,DEPT AERONAUT & ASTRONAUT,WRIGHT PATTERSON AFB,OH 45433, USA. NR 11 TC 4 Z9 5 U1 1 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0045-7949 J9 COMPUT STRUCT JI Comput. Struct. PD AUG 17 PY 1992 VL 44 IS 5 BP 1055 EP 1063 DI 10.1016/0045-7949(92)90328-W PG 9 WC Computer Science, Interdisciplinary Applications; Engineering, Civil SC Computer Science; Engineering GA JM702 UT WOS:A1992JM70200011 ER PT J AU JOSEPH, RE ENGHARDT, MH DOERING, DL BROWN, BF SHAFFER, DW RAVAL, HB AF JOSEPH, RE ENGHARDT, MH DOERING, DL BROWN, BF SHAFFER, DW RAVAL, HB TI SMALL-CELL NEUROENDOCRINE CARCINOMA OF THE VAGINA SO CANCER LA English DT Article DE VAGINAL CARCINOMA; SMALL CELL CARCINOMA; NEUROENDOCRINE; IMMUNOSTAINING; HISTOGENESIS ID NEURAL CREST; ENDOCRINE; CERVIX; MARKERS; TRACT AB A 65-year-old woman with a history of recurrent vaginal intraepithelial neoplasia was found to have small cell carcinoma (SCC). Exfoliative cytology was instrumental in the discovery of each episode of vaginal neoplasia. Thorough examination of the patient established the tumor as being primary to the vagina, and immunohistochemistry confirmed it to be a neuroendocrine SCC. Eleven patients with neuroendocrine SCC of the vagina have been reported previously. Morphologic characteristics and histogenesis are discussed within the context of the embryology and natural history of extrapulmonary-genital SCC. They have been classified in the amine precursor uptake and decarboxylation family of neoplasms. Originally, a neuroectodermal origin was proposed, but derivation now is thought to be from multipotential epithelial stem cells of the genital tract. Neuroendocrine SCC tends to be an aggressive neoplasm with a propensity for early spread. Long-term survival for patients with vaginal SCC has not been documented. Therapeutic decisions regarding SCC from this site have been based on information gained from the treatment of these tumors elsewhere. Combined modality therapy using initial surgery and adjuvant treatment, including systemic chemotherapy and local exposure to radiation, has produced an apparent complete response in our patient. C1 BROOKE ARMY MED CTR,DEPT PATHOL,FT SAM HOUSTON,TX 78234. DARNALL ARMY COMMUNITY HOSP,DEPT OBSTET & GYNECOL,FT HOOD,TX. BROOKE ARMY MED CTR,HEMATOL ONCOL SERV,FT SAM HOUSTON,TX 78234. UNIV LOUISVILLE,DEPT OBSTET & GYNECOL,GYNECOL ONCOL SERV,LOUISVILLE,KY 40292. NR 27 TC 15 Z9 15 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0008-543X J9 CANCER JI Cancer PD AUG 15 PY 1992 VL 70 IS 4 BP 784 EP 789 DI 10.1002/1097-0142(19920815)70:4<784::AID-CNCR2820700412>3.0.CO;2-0 PG 6 WC Oncology SC Oncology GA JH654 UT WOS:A1992JH65400011 PM 1322783 ER PT J AU GANT, TA DUTTA, M ELMASRY, NA BEDAIR, SM STROSCIO, MA AF GANT, TA DUTTA, M ELMASRY, NA BEDAIR, SM STROSCIO, MA TI RAMAN-STUDY OF ORDERING IN GA1-XINXP SO PHYSICAL REVIEW B LA English DT Article ID VAPOR-PHASE EPITAXY; ATOMIC LAYER EPITAXY; GROWTH TEMPERATURE; BAND-GAP; GAINP; GA0.5IN0.5P; SCATTERING; GAXIN1-XP; ALLOY; INTERFERENCE AB We report on a Raman study of several Ga1-xInxP samples grown by atomic layer epitaxy. The Ga1-xInxP LO-phonon Raman peaks are present in the z(xx)zBAR (polarized) spectrum as well as the z(xy)zBAR (depolarized) spectrum, in contradiction to the usual selection rules for zinc-blende crystals. Several possible sources for the "forbidden" scattering are discussed, including resonant Raman and alloy effects. In addition, the possibility of ordered phases of Ga1-xInxP (in the CuPt structure) is discussed. The Raman selection rules of the ordered phase are derived using group theory. These phenomena can be further investigated by taking Raman spectra polarized along [110] and [110BAR]. C1 N CAROLINA STATE UNIV,RALEIGH,NC 27695. USA,RES OFF,RES TRIANGLE PK,NC 27709. RP GANT, TA (reprint author), USA,ELECTR TECHNOL & DEVICES LAB,SLCET ED,FT MONMOUTH,NJ 07703, USA. NR 23 TC 11 Z9 11 U1 1 U2 1 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0163-1829 J9 PHYS REV B JI Phys. Rev. B PD AUG 15 PY 1992 VL 46 IS 7 BP 3834 EP 3838 DI 10.1103/PhysRevB.46.3834 PG 5 WC Physics, Condensed Matter SC Physics GA JJ846 UT WOS:A1992JJ84600016 ER PT J AU CAMPOS, VB DASSARMA, S STROSCIO, MA AF CAMPOS, VB DASSARMA, S STROSCIO, MA TI PHONON-CONFINEMENT EFFECT ON ELECTRON-ENERGY LOSS IN ONE-DIMENSIONAL QUANTUM WIRES SO PHYSICAL REVIEW B LA English DT Article ID DOUBLE HETEROSTRUCTURES; RELAXATION; WELLS; SCATTERING; SYSTEMS; GAS AB We calculate, within the electron-temperature model, hot-electron intrasubband energy relaxation rates via LO-phonon emission in GaAs quantum wires, taking into account quantum degeneracy, dynamical screening, hot-phonon bottleneck, and, in particular, phonon confinement. Two prevailing macroscopic models of phonon confinement, namely, the slab or the electrostatic model and the guided or the mechanical model, are compared quantitatively. We find that the slab model, while giving relaxation rates comparable to the bulk-phonon emission rates, leads to an order of magnitude faster relaxation than the guided model. For reasonable parameter values, the hot-phonon-bottleneck effect is found to be the single most important physical mechanism determining energy relaxation. Numerical values for electronic-energy-loss rates in GaAs quantum wires are provided for both models of phonon confinement for a range of values of the relevant parameters, including confinement size, carrier density, hot-phonon lifetime, and electron temperature. C1 USA,RES OFF,RES TRIANGLE PK,NC 27709. UNIV FED SAO CARLOS,DEPT FIS,BR-13560 SAO CARLOS,SP,BRAZIL. RP CAMPOS, VB (reprint author), UNIV MARYLAND,DEPT PHYS,JOINT PROGRAM ADV ELECTR MAT,COLL PK,MD 20742, USA. RI Das Sarma, Sankar/B-2400-2009 OI Das Sarma, Sankar/0000-0002-0439-986X NR 21 TC 43 Z9 43 U1 0 U2 1 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0163-1829 J9 PHYS REV B JI Phys. Rev. B PD AUG 15 PY 1992 VL 46 IS 7 BP 3849 EP 3853 DI 10.1103/PhysRevB.46.3849 PG 5 WC Physics, Condensed Matter SC Physics GA JJ846 UT WOS:A1992JJ84600018 ER PT J AU HIGGINS, TP HARVEY, JF STURZEBECHER, DJ PAOLELLA, AC LUX, RA AF HIGGINS, TP HARVEY, JF STURZEBECHER, DJ PAOLELLA, AC LUX, RA TI DIRECT OPTICAL FREQUENCY-MODULATION AND INJECTION LOCKING OF RESONANT TUNNEL-DIODE OSCILLATOR SO ELECTRONICS LETTERS LA English DT Article DE MICROWAVE DEVICES; DIODES; OPTICAL CONTROL OF MICROWAVES AB Preliminary results indicate that a resonant tunnel diode (RTD) oscillator can be optically tuned, frequency modulated, and injection locked. Experiments were performed in which a 2.8 GHz RTD oscillator was frequency modulated from DC to 100 MHz and injection locked over a 150 kHz bandwidth with a laser diode via fibre optics. RP HIGGINS, TP (reprint author), USA,ELECTR TECHNOL & DEVICES LAB,FT MONMOUTH,NJ 07703, USA. NR 5 TC 14 Z9 14 U1 0 U2 2 PU IEE-INST ELEC ENG PI HERTFORD PA MICHAEL FARADAY HOUSE SIX HILLS WAY STEVENAGE, HERTFORD, ENGLAND SG1 2AY SN 0013-5194 J9 ELECTRON LETT JI Electron. Lett. PD AUG 13 PY 1992 VL 28 IS 17 BP 1574 EP 1576 DI 10.1049/el:19921002 PG 3 WC Engineering, Electrical & Electronic SC Engineering GA JK074 UT WOS:A1992JK07400007 ER PT J AU BANCROFT, WH AF BANCROFT, WH TI HEPATITIS-A VACCINE SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Editorial Material ID VIRUS RP BANCROFT, WH (reprint author), USA,MED RES & DEV COMMAND,FREDERICK,MD 21702, USA. NR 15 TC 10 Z9 10 U1 0 U2 0 PU MASS MEDICAL SOC PI BOSTON PA 10 SHATTUCK, BOSTON, MA 02115 SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD AUG 13 PY 1992 VL 327 IS 7 BP 488 EP 490 DI 10.1056/NEJM199208133270709 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA JH340 UT WOS:A1992JH34000009 PM 1320741 ER PT J AU HERWALDT, BL NEVA, FA BERMAN, JD AF HERWALDT, BL NEVA, FA BERMAN, JD TI ALLOPURINOL IN THE TREATMENT OF AMERICAN CUTANEOUS LEISHMANIASIS SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Letter ID EFFICACY C1 NIH,BETHESDA,MD 20892. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. RP HERWALDT, BL (reprint author), CTR DIS CONTROL,ATLANTA,GA 30333, USA. NR 8 TC 10 Z9 10 U1 0 U2 0 PU MASS MEDICAL SOC PI BOSTON PA 10 SHATTUCK, BOSTON, MA 02115 SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD AUG 13 PY 1992 VL 327 IS 7 BP 498 EP 498 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA JH340 UT WOS:A1992JH34000021 PM 1625745 ER PT J AU JOHNSON, JL AF JOHNSON, JL TI WHITE-LIGHT OPTICAL FOURIER-TRANSFORM DEVICE SO APPLIED OPTICS LA English DT Article DE INCOHERENT FOURIER TRANSFORM; SAVART PLATE; POLARIZATION; OPTICAL CORRELATOR AB The construction and operation of a new optical phase plate assembly is described that takes the Fourier transform of an intensity image in white light. It consists of symmetrical wedges of birefringent crystals that induce an angle between the wave fronts of the polarized components of the output beam. The wave-front angle is shown to be linearly proportional to the angle of incidence. This is sufficient to generate the necessary phase factor for a Fourier transform. RP JOHNSON, JL (reprint author), USA,MISSILE COMMAND,WEAPONS SCI DIRECTORATE CTR DEV & ENGN,AMSMI RD WS PO,REDSTONE ARSENAL,AL 35898, USA. NR 10 TC 0 Z9 0 U1 0 U2 0 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0003-6935 J9 APPL OPTICS JI Appl. Optics PD AUG 10 PY 1992 VL 31 IS 23 BP 4688 EP 4692 PG 5 WC Optics SC Optics GA JH623 UT WOS:A1992JH62300013 PM 20725479 ER PT J AU TANONE, A UANG, CM YU, FTS TAM, EC GREGORY, DA AF TANONE, A UANG, CM YU, FTS TAM, EC GREGORY, DA TI EFFECTS OF THRESHOLDING IN JOINT-TRANSFORM CORRELATION SO APPLIED OPTICS LA English DT Article ID SPATIAL LIGHT-MODULATOR; PATTERN-RECOGNITION; BINARY PHASE; BINARIZATION AB The joint-transform power spectrum of two identical objects can be represented as a one-dimensional sinusoidal grating modulated by a Fourier transform, and the correlation peaks can be regarded as the first-order diffraction of the grating. The peak intensity and the width are then determined by the aperture and the modulation of the grating. Based on this analysis, it is shown that dc blocking, hard clipping, or binarization of the power spectrum results in higher correlation peak intensity and a narrower peak width. Direct-current blocking is also found to be preferable if the input pattern to the correlator is corrupted by noise. C1 UNIV N CAROLINA, DEPT PHYS, CHARLOTTE, NC 28223 USA. USA, MISSILE COMMAND, REDSTONE ARSENAL, AL 35898 USA. RP TANONE, A (reprint author), PENN STATE UNIV, DEPT ELECT & COMP ENGN, UNIV PK, PA 16802 USA. NR 18 TC 14 Z9 17 U1 0 U2 0 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X EI 2155-3165 J9 APPL OPTICS JI Appl. Optics PD AUG 10 PY 1992 VL 31 IS 23 BP 4816 EP 4822 PG 7 WC Optics SC Optics GA JH623 UT WOS:A1992JH62300027 PM 20725493 ER PT J AU VENNERSTROM, JL FU, HN ELLIS, WY AGER, AL WOOD, JK ANDERSEN, SL GERENA, L MILHOUS, WK AF VENNERSTROM, JL FU, HN ELLIS, WY AGER, AL WOOD, JK ANDERSEN, SL GERENA, L MILHOUS, WK TI DISPIRO-1,2,4,5-TETRAOXANES - A NEW CLASS OF ANTIMALARIAL PEROXIDES SO JOURNAL OF MEDICINAL CHEMISTRY LA English DT Article ID QINGHAOSU ARTEMISININ; 1,2,4-TRIOXANES; DERIVATIVES; INVITRO; DRUGS AB Dispiro-1,2,4,5-tetraoxanes 2-4 were synthesized as potential peroxide antimalarial drugs. They had curative activity against Plasmodium berghei in vivo at single doses of 320 and 640 mg/kg which confirms earlier unpublished data. Moreover, artemisinin (1) and 4 had equivalent ED50's against P. berghei in vivo in the multiple-dose Thompson test; neither showed any evidence of acute toxicity at total doses of more than 12 g/kg. Dispiro-1,2,4,5-tetraoxane 4 had IC50's comparable to those of 1 against Plasmodium falciparum clones in vitro. These results confirm the potential of dispiro-1,2,4,5-tetraoxanes as a new class of inexpensive peroxide antimalarial drugs. C1 UNIV MIAMI,SCH MED,DEPT MICROBIOL & IMMUNOL,CTR TROP PARASIT DIS,MIAMI,FL 33177. WALTER REED ARMY MED CTR,DEPT EXPTL THERAPEUT,WASHINGTON,DC 20307. UNIV NEBRASKA,DEPT CHEM,OMAHA,NE 68182. RP VENNERSTROM, JL (reprint author), UNIV NEBRASKA,MED CTR,COLL PHARM,600 S 42ND ST,OMAHA,NE 68198, USA. FU NIAID NIH HHS [1 R15 AI28012-01] NR 24 TC 146 Z9 149 U1 2 U2 11 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0022-2623 J9 J MED CHEM JI J. Med. Chem. PD AUG 7 PY 1992 VL 35 IS 16 BP 3023 EP 3027 DI 10.1021/jm00094a015 PG 5 WC Chemistry, Medicinal SC Pharmacology & Pharmacy GA JH469 UT WOS:A1992JH46900015 PM 1501229 ER PT J AU BENNETT, LS SORRELL, FY SIMONSEN, IK HORIE, Y IYER, KR AF BENNETT, LS SORRELL, FY SIMONSEN, IK HORIE, Y IYER, KR TI ULTRAFAST CHEMICAL-REACTIONS BETWEEN NICKEL AND ALUMINUM POWDERS DURING SHOCK LOADING SO APPLIED PHYSICS LETTERS LA English DT Article AB A recent investigation of powdered Ni-Al systems subject to shock loading has yielded evidence that reactions occur during the shock front. Time-resolved measurements of normal shock pressure indicate that an "excess pressure" is generated possibly due to an exothermic reaction in the Ni-Al system. These reactions appear to occur during the 100 ns that represent the shock front. A clear reaction threshold is observed and corroborated by micrographs of the recovered samples. C1 USA,RES OFF,RES TRIANGLE PK,NC 27709. RP BENNETT, LS (reprint author), N CAROLINA STATE UNIV,RALEIGH,NC 27695, USA. NR 7 TC 13 Z9 13 U1 1 U2 4 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD AUG 3 PY 1992 VL 61 IS 5 BP 520 EP 521 DI 10.1063/1.107874 PG 2 WC Physics, Applied SC Physics GA JG157 UT WOS:A1992JG15700007 ER PT J AU REINKOBER, TE AF REINKOBER, TE TI ARMY COUNTERMEASURES TARGET TECHNOLOGY ADVANCES SO AEROSPACE AMERICA LA English DT Article RP REINKOBER, TE (reprint author), USA,PROGRAM EXECUT OFF,WASHINGTON,DC 20310, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091 SN 0740-722X J9 AEROSPACE AM JI Aerosp. Am. PD AUG PY 1992 VL 30 IS 8 BP 46 EP 46 PG 1 WC Engineering, Aerospace SC Engineering GA JG683 UT WOS:A1992JG68300012 ER PT J AU JACKSON, KE AF JACKSON, KE TI SCALING EFFECTS IN THE FLEXURAL RESPONSE AND FAILURE OF COMPOSITE BEAMS SO AIAA JOURNAL LA English DT Article AB An experimental program was conducted in which scale model graphite-epoxy composite beams were loaded in bending until failure to investigate the effects of specimen size on flexural response and strength. Tests were performed on unidirectional, angle-ply, cross-ply, and quasi-isotropic beams of eight different scaled sizes ranging from 1/6 scale to full scale. The beams were subjected to an eccentric axial compressive load designed to promote large bending deformations and rotations. Results indicated that, although normalized flexural response was independent of specimen size, a significant scale effect in strength was observed for all laminate types. Typically, failure stresses and strains decreased as the size of the beam specimen increased from subscale to the full-scale prototype. Standard failure criteria for composite materials, such as the maximum stress, maximum strain, and tensor polynomial criteria, cannot predict the strength degradation with increasing specimen size. Consequently, a Weibull statistical model and a fracture mechanics model were used to analyze the strength scale effect. RP JACKSON, KE (reprint author), NASA,LANGLEY RES CTR,USA,AEROSTRUCT DIRECTORATE,MAIL STOP 495,HAMPTON,VA 23665, USA. NR 20 TC 16 Z9 16 U1 1 U2 1 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091 SN 0001-1452 J9 AIAA J JI AIAA J. PD AUG PY 1992 VL 30 IS 8 BP 2099 EP 2105 DI 10.2514/3.11186 PG 7 WC Engineering, Aerospace SC Engineering GA JG675 UT WOS:A1992JG67500023 ER PT J AU REDFIELD, R BIRX, D KETTER, N POLONIS, V JOHNSON, S DAVIS, C SMITH, G OSTER, C BURKE, D AF REDFIELD, R BIRX, D KETTER, N POLONIS, V JOHNSON, S DAVIS, C SMITH, G OSTER, C BURKE, D TI VACCINE THERAPY USING RGP 160 IN EARLY HIV-INFECTION SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Article; Proceedings Paper CT INTERNATIONAL CONF ON ADVANCES IN AIDS VACCINE DEVELOPMENT / 4TH ANNUAL MEETING OF THE NATIONAL COOPERATIVE VACCINE DEVELOPMENT GROUP FOR AIDS CY OCT 15-19, 1991 CL MARCO ISLAND, FL SP NATL COOPERAT VACCINE DEV GRP AIDS C1 MICROGENESYS INC,MERIDEN,CT 06450. HENRY M JACKSON FDN,BETHESDA,MD. RP REDFIELD, R (reprint author), WALTER REED ARMY MED CTR,WALTER REED INST RES INFECT DIS,DEPT RETROVIRAL RES,WASHINGTON,DC 20307, USA. NR 0 TC 6 Z9 6 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD AUG PY 1992 VL 8 IS 8 BP 1333 EP 1333 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA JR904 UT WOS:A1992JR90400007 PM 1361350 ER PT J AU ALVING, CR GLASS, M DETRICK, B AF ALVING, CR GLASS, M DETRICK, B TI SUMMARY - ADJUVANTS CLINICAL-TRIALS WORKING GROUP SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Article; Proceedings Paper CT INTERNATIONAL CONF ON ADVANCES IN AIDS VACCINE DEVELOPMENT / 4TH ANNUAL MEETING OF THE NATIONAL COOPERATIVE VACCINE DEVELOPMENT GROUP FOR AIDS CY OCT 15-19, 1991 CL MARCO ISLAND, FL SP NATL COOPERAT VACCINE DEV GRP AIDS C1 GEORGE WASHINGTON UNIV,MED CTR,DEPT PATHOL,WASHINGTON,DC 20037. NIAID,DIV AIDS,BETHESDA,MD 20892. RP ALVING, CR (reprint author), WALTER REED ARMY MED CTR,DEPT MEMBRANE BIOCHEM,WASHINGTON,DC 20307, USA. NR 0 TC 13 Z9 13 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD AUG PY 1992 VL 8 IS 8 BP 1427 EP 1430 PG 4 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA JR904 UT WOS:A1992JR90400037 PM 1466973 ER PT J AU LOUWAGIE, J MCCUTCHAN, F VANDERGROEN, G PEETERS, M FRANSEN, K PIOT, P GERSHYDAMET, GM ROELANTS, G VANHEUVERSWYN, H EDDY, G UNGAR, B BURKE, D AF LOUWAGIE, J MCCUTCHAN, F VANDERGROEN, G PEETERS, M FRANSEN, K PIOT, P GERSHYDAMET, GM ROELANTS, G VANHEUVERSWYN, H EDDY, G UNGAR, B BURKE, D TI GENETIC COMPARISON OF HIV-1 ISOLATES FROM AFRICA, EUROPE, AND NORTH-AMERICA SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Article; Proceedings Paper CT INTERNATIONAL CONF ON ADVANCES IN AIDS VACCINE DEVELOPMENT / 4TH ANNUAL MEETING OF THE NATIONAL COOPERATIVE VACCINE DEVELOPMENT GROUP FOR AIDS CY OCT 15-19, 1991 CL MARCO ISLAND, FL SP NATL COOPERAT VACCINE DEV GRP AIDS ID NUCLEOTIDE-SEQUENCE ANALYSIS; HUMAN IMMUNODEFICIENCY VIRUS; STRAIN C1 INST TROP MED PRINCE LEOPOLD,B-2000 ANTWERP,BELGIUM. INST PASTEUR COTE IVOIRE,ABIDJAN,COTE IVOIRE. CTR INT RECH MED FRANCEVILLE,FRANCEVILLE,GABON. INNOGENET NV,ANTWERP,BELGIUM. WALTER REED ARMY MED CTR,DIV RETROVIROL,WASHINGTON,DC 20307. RP LOUWAGIE, J (reprint author), HENRY M JACKSON FDN,1500 E GUDE DR,ROCKVILLE,MD 20850, USA. OI /0000-0002-5704-8094 NR 8 TC 16 Z9 16 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD AUG PY 1992 VL 8 IS 8 BP 1467 EP 1469 PG 3 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA JR904 UT WOS:A1992JR90400049 PM 1466983 ER PT J AU SHAFFERMAN, A LEWIS, MG MCCUTCHAN, FE BENVENISTE, RE JAHRLING, PB HICKMAN, RL LAI, CY BURKE, DS EDDY, GA AF SHAFFERMAN, A LEWIS, MG MCCUTCHAN, FE BENVENISTE, RE JAHRLING, PB HICKMAN, RL LAI, CY BURKE, DS EDDY, GA TI VACCINATION OF MACAQUES WITH SIV CONSERVED ENVELOPE PEPTIDES SUPPRESSED INFECTION AND PREVENTED DISEASE PROGRESSION AND TRANSMISSION SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Article; Proceedings Paper CT INTERNATIONAL CONF ON ADVANCES IN AIDS VACCINE DEVELOPMENT / 4TH ANNUAL MEETING OF THE NATIONAL COOPERATIVE VACCINE DEVELOPMENT GROUP FOR AIDS CY OCT 15-19, 1991 CL MARCO ISLAND, FL SP NATL COOPERAT VACCINE DEV GRP AIDS ID IMMUNODEFICIENCY VIRUS-INFECTION; RHESUS MACAQUES; CYNOMOLGUS MONKEYS; IMMUNE-RESPONSE; PROTECTION; SEQUENCES; ANTIBODY C1 HENRY M JACKSON FDN,RES LAB,ROCKVILLE,MD 20852. FREDERICK RES CTR,FREDERICK,MD 21701. NCI,VIRAL CARCINOGENESIS LAB,BETHESDA,MD 20892. USA,MED RES INST INFECT DIS,FREDERICK,MD 21701. WALTER REED ARMY MED CTR,DIV VIROL,WASHINGTON,DC 20307. RP SHAFFERMAN, A (reprint author), ISRAEL INST BIOL RES,DEPT BIOCHEM,IL-70450 NESS ZIONA,ISRAEL. OI /0000-0002-5704-8094 NR 17 TC 6 Z9 6 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD AUG PY 1992 VL 8 IS 8 BP 1483 EP 1487 PG 5 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA JR904 UT WOS:A1992JR90400054 PM 1281660 ER PT J AU BURKE, DS AF BURKE, DS TI INTERNATIONAL VACCINE EFFICACY TRIALS - SPECIAL CONSIDERATIONS SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Article; Proceedings Paper CT INTERNATIONAL CONF ON ADVANCES IN AIDS VACCINE DEVELOPMENT / 4TH ANNUAL MEETING OF THE NATIONAL COOPERATIVE VACCINE DEVELOPMENT GROUP FOR AIDS CY OCT 15-19, 1991 CL MARCO ISLAND, FL SP NATL COOPERAT VACCINE DEV GRP AIDS RP BURKE, DS (reprint author), WALTER REED ARMY MED CTR,13 TAFT COURT,ROCKVILLE,MD 20850, USA. NR 0 TC 3 Z9 3 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD AUG PY 1992 VL 8 IS 8 BP 1531 EP 1531 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA JR904 UT WOS:A1992JR90400066 PM 1466998 ER PT J AU BASS, JW ROSCELLI, JD AF BASS, JW ROSCELLI, JD TI RE - GUILLAIN-BARRE-SYNDROME AND INFLUENZA VACCINATION IN THE US-ARMY, 1980-1988 - REPLY SO AMERICAN JOURNAL OF EPIDEMIOLOGY LA English DT Letter RP BASS, JW (reprint author), TRIPLER ARMY MED CTR,DEPT PEDIAT,HONOLULU,HI 96859, USA. NR 2 TC 0 Z9 0 U1 0 U2 0 PU JOHNS HOPKINS UNIV SCHOOL HYGIENE PUB HEALTH PI BALTIMORE PA 111 MARKET PLACE, STE 840, BALTIMORE, MD 21202-6709 SN 0002-9262 J9 AM J EPIDEMIOL JI Am. J. Epidemiol. PD AUG 1 PY 1992 VL 136 IS 3 BP 375 EP 376 PG 2 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA JR446 UT WOS:A1992JR44600014 ER PT J AU SUTTON, GP SOPER, JT BLESSING, JA HATCH, KD BARNHILL, DR AF SUTTON, GP SOPER, JT BLESSING, JA HATCH, KD BARNHILL, DR TI IFOSFAMIDE ALONE AND IN COMBINATION IN THE TREATMENT OF REFRACTORY MALIGNANT GESTATIONAL TROPHOBLASTIC DISEASE SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Article; Proceedings Paper CT 54TH ANNUAL MEETING OF THE SOUTH ATLANTIC ASSOC OF OBSTETRICIANS AND GYNECOLOGISTS CY JAN 26-29, 1992 CL PALM BEACH, FL SP S ATLANTIC ASSOC OBSTETRICIANS & GYNECOLOGISTS DE IFOSFAMIDE; REFRACTORY GESTATIONAL TROPHOBLASTIC DISEASE ID SALVAGE THERAPY; POOR PROGNOSIS; CIS-PLATINUM; CISPLATIN; CHORIOCARCINOMA; VINBLASTINE; BLEOMYCIN; METHOTREXATE; CHEMOTHERAPY; VINCRISTINE AB OBJECTIVE: We attempted to evaluate the use of ifosfamide either alone or in combination in patients with refractory malignant gestational trophoblastic disease. STUDY DESIGN: Our study comprised, in part, a phase II multiinstitutional trial of ifosfamide in refractory gynecologic malignancies and, in part, a review of institutional experience with ifosfamide in combination chemotherapy. RESULTS: Single-agent ifosfamide produced a significant response in titer in one of two patients with refractory choriocarcinoma. Ifosfamide with etoposide and cisplatin (also known as VIP) resulted in significant response in human chorionic gonadotropin titers in three patients with highly refractory metastatic gestational trophoblastic disease and one cure in this group of patients. CONCLUSION: Ifosfamide has activity in refractory choriocarcinoma and, when combined with etoposide and cisplatin (VIP), may be curative. C1 INDIANA UNIV,SCH MED,DEPT OBSTET & GYNECOL,GYNECOL ONCOL SECT,INDIANAPOLIS,IN 46202. DUKE UNIV,MED CTR,DEPT OBSTET & GYNECOL,DIV GYNECOL ONCOL,DURHAM,NC 27710. NEW YORK STATE DEPT HLTH,ROSWELL PK MEM INST,GYNECOL ONCOL GRP,BUFFALO,NY 14263. UNIV ARIZONA,ARIZONA HLTH SCI CTR,COLL MED,DEPT OBSTET & GYNECOL,DIV GYNECOL ONCOL,TUCSON,AZ 85724. WALTER REED ARMY MED CTR,DEPT OBSTET & GYNECOL,GYNECOL ONCOL SERV,WASHINGTON,DC 20307. NR 19 TC 29 Z9 30 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0002-9378 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD AUG PY 1992 VL 167 IS 2 BP 489 EP 495 PG 7 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA JJ372 UT WOS:A1992JJ37200032 PM 1323213 ER PT J AU SMITH, GA VONFRAUNHOFER, JA CASEY, GR AF SMITH, GA VONFRAUNHOFER, JA CASEY, GR TI THE EFFECT OF CLINICAL USE AND STERILIZATION ON SELECTED ORTHODONTIC ARCH WIRES SO AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS LA English DT Article ID MECHANICAL-PROPERTIES; BETA-TITANIUM; NITINOL; CORROSION; ALLOY AB The effect of clinical use and various sterilization/disinfection protocols on three types of nickel-titanium, and one type each of beta-titanium and stainless steel arch wire was evaluated. The sterilization/disinfection procedures included disinfection alone or in concert with steam autoclave, dry heat, or cold solution sterilization. No clinically significant differences were found between new and used arch wires. The direction of load application to the arch wire and the particular segment of arch wire tested was found to cause substantial differences in generated loads for certain arch wire types. C1 USA,RESIDENCY PROGRAM,FT KNOX,KY. UNIV LOUISVILLE,BIOMAT SCI,LOUISVILLE,KY 40292. RP SMITH, GA (reprint author), USA,DENT CORPS,FT LEWIS,WA 98431, USA. NR 35 TC 7 Z9 7 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0889-5406 J9 AM J ORTHOD DENTOFAC JI Am. J. Orthod. Dentofac. Orthop. PD AUG PY 1992 VL 102 IS 2 BP 153 EP 159 DI 10.1016/0889-5406(92)70028-9 PG 7 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA JH855 UT WOS:A1992JH85500009 PM 1636633 ER PT J AU OLSON, TA LEVINE, RF MAZUR, EM WRIGHT, DG SALVADO, AJ AF OLSON, TA LEVINE, RF MAZUR, EM WRIGHT, DG SALVADO, AJ TI MEGAKARYOCYTES AND MEGAKARYOCYTE PROGENITORS IN HUMAN CORD BLOOD SO AMERICAN JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY LA English DT Article DE NEWBORN THROMBOCYTOPENIA; NEWBORN MEGAKARYOCYTES; MEGAKARYOCYTOPOIESIS ID COLONY-STIMULATING FACTOR; HEMATOPOIETIC STEM-CELLS; NEONATAL THROMBOCYTOPENIA; ERYTHROID PROGENITORS; BONE-MARROW; ERYTHROPOIETIN; PREMATURITY; MATURATION; INFANTS; INVITRO AB Thrombocytopenia contributes significantly to morbidity in the sick term or preterm infant. However, few data exist on newborn's megakaryocytes and megakaryocyte progenitor cells (CFU-MK). We therefore studied CFU-MK in term and preterm infant cord blood and compared the results with data on CFU-MK from adult bone marrow and adult peripheral blood in a plasma clot culture with postirradiated aplastic canine serum (PIACS) as a source of megakaryocyte colony-stimulating activity. The number of CFU-MK and the number of cells per CFU-MK were counted with an immunofluorescent method at day 12. The effect of T-lymphocyte depletion on cord blood cultures for CFU-MK was studied with PIACS and a partially purified product of PIACS. We also studied individual megakaryocytes from newborns. The number and sizes of circulating megakaryocytes, isolated from adult peripheral blood and term venous cord blood by elutriation, were compared. Term and preterm cord blood contained more CFU-MK than adult peripheral blood. The numbers of CFU-MK in preterm cord blood were comparable to those in adult bone marrow. When the number of cells per colony were compared, cord blood contained significantly more cells than adult marrow CFU-MK. The depletion of T lymphocytes did not significantly change the growth of CFU-MK compared to nondepleted cultures. A substantial number of circulating megakaryocytes were obtained from venous cord blood, though they were significantly smaller than adult peripheral blood megakaryocytes. Since cord blood is easily obtained and contains large numbers of megakaryocytes and CFU-MK, it may provide a convenient model for studying the regulation of fetal megakaryocytopoiesis. C1 OHIO STATE UNIV,COLUMBUS CHILDRENS HOSP,DEPT PEDIAT,COLUMBUS,OH 43210. MIRIAM HOSP,DEPT MED,PROVIDENCE,RI 02906. BROWN UNIV,PROVIDENCE,RI 02912. VET ADM MED CTR,DIV RES & DEV,WASHINGTON,DC 20422. GEORGE WASHINGTON UNIV,WASHINGTON,DC 20052. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 44 TC 42 Z9 42 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0192-8562 J9 AM J PEDIAT HEMATOL PD AUG PY 1992 VL 14 IS 3 BP 241 EP 247 PG 7 WC Oncology; Hematology; Pediatrics SC Oncology; Hematology; Pediatrics GA JD362 UT WOS:A1992JD36200011 PM 1510195 ER PT J AU SHAILESH, LTC KADAKIA, C SULLIVAN, HO STARNES, E AF SHAILESH, LTC KADAKIA, C SULLIVAN, HO STARNES, E TI PERCUTANEOUS ENDOSCOPIC GASTROSTOMY OR JEJUNOSTOMY AND THE INCIDENCE OF ASPIRATION IN 79 PATIENTS SO AMERICAN JOURNAL OF SURGERY LA English DT Article ID PROSPECTIVE RANDOMIZED TRIAL; LAPAROTOMY; PUSH AB Percutaneous endoscopic gastrostomy (PEG) and percutaneous endoscopic jejunostomy (PEJ) are well-accepted procedures for long-term enteral alimentation. PEG has replaced surgical gastrostomy at many institutions because of its safety and ease. This study was undertaken to evaluate the indications for PEG and PEJ, as well as their success rates, complications with special attention to aspiration, and long-term follow-up. We were specifically interested in reviewing the problem of aspiration in patients with PEG and PEJ. A retrospective review of 79 patients at Brooke Army Medical Center over a 3-year period was done. PEG or PEJ was successful in 79 of 81 patients (97%). The most common indications were neurologic disorders in 46 patients (58%) and cancer in 20 (25.3%). Complications other than aspiration occurred in 11 patients (14%). Aspiration occurred in nine patients after PEG or PEJ (11.4%); six patients had experienced aspiration prior to PEG or PEJ. Six patients had a jejunostomy tube placed through the PEG for prevention of aspiration, and three died of continued aspiration. We conclude that aspiration is not prevented by PEJ, continues to be a major problem after PEJ, and becomes manifest for the first time after PEG. RP SHAILESH, LTC (reprint author), BROOKE ARMY MED CTR,DEPT MED,GASTROENTEROL SERV,FT SAM HOUSTON,TX 78234, USA. NR 23 TC 59 Z9 59 U1 0 U2 0 PU CAHNERS PUBL CO PI NEW YORK PA 249 WEST 17 STREET, NEW YORK, NY 10011 SN 0002-9610 J9 AM J SURG JI Am. J. Surg. PD AUG PY 1992 VL 164 IS 2 BP 114 EP 118 PG 5 WC Surgery SC Surgery GA JG680 UT WOS:A1992JG68000007 ER PT J AU ARTHUR, RR LOFTS, RS GOMEZ, J GLASS, GE LEDUC, JW CHILDS, JE AF ARTHUR, RR LOFTS, RS GOMEZ, J GLASS, GE LEDUC, JW CHILDS, JE TI GROUPING OF HANTAVIRUSES BY SMALL(S) GENOME SEGMENT POLYMERASE CHAIN-REACTION AND AMPLIFICATION OF VIRAL-RNA FROM WILD-CAUGHT RATS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID NUCLEOTIDE-SEQUENCE ANALYSIS; KOREAN HEMORRHAGIC-FEVER; RENAL SYNDROME VIRUS; ETIOLOGIC AGENT; HANTAAN VIRUS; NEPHROPATHIA-EPIDEMICA; UNITED-STATES; S-GENOME; INFECTION; BALTIMORE AB A single pair of consensus primers in the polymerase chain reaction (PCR) amplified a conserved region of the small genome segment of twenty hantavirus isolates. Isolates tested included representatives of the four recognized hantaviruses, Hantaan, Seoul, Puumala and Prospect Hill, as well as isolates from Mus musculus (Leakey), Bandicota indica (Thailand 749), and Suncus murinus (Thottapalayam). Viruses from the Nairovirus and Phlebovirus genera yielded negative results. The amplification products were 281-nucleotide pairs (np) in length, with the exception of Thottapalayam, which had an amplification product of approximately 320 np. Products of all isolates were detected by Southern hybridization with a P-32-labeled Hantaan 76-118 amplicon, while an oligonucleotide probe to a conserved region of the amplified fragment failed to detect some isolates of Seoul and Puumala viruses. Restriction endonuclease analysis allowed three groupings: Hantaan-like viruses, Seoul-like viruses, and a diverse group of patterns for the other viruses. Differences were found within the Seoul-like virus group by this method, whereas the Hantaan-like viruses were shown to be similar. RNA extracted from tissues of sero-positive and seronegative rats trapped in Baltimore showed the practical application of the test. Hantavirus-specific RNA was detected in 12 (92%) of 13 seropositive rats, but not in seronegative rats. This simple method for detecting and characterizing hantaviruses has potential for epidemiologic studies and for diagnosing human hantavirus infections. C1 USA,MED RES INST INFECT DIS,FREDERICK,MD 21702. RP ARTHUR, RR (reprint author), JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,DEPT IMMUNOL & INFECT DIS,615 N WOLFE ST,BALTIMORE,MD 21205, USA. RI Childs, James/B-4002-2012 NR 37 TC 44 Z9 44 U1 0 U2 4 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD AUG PY 1992 VL 47 IS 2 BP 210 EP 224 PG 15 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA JL246 UT WOS:A1992JL24600011 PM 1354416 ER PT J AU BURKE, TA AF BURKE, TA TI ADVERSE OUTCOMES AND THE MULTICENTER STUDY OF GENERAL-ANESTHESIA .1. SO ANESTHESIOLOGY LA English DT Letter RP BURKE, TA (reprint author), DWIGHT D EISENHOWER ARMY MED CTR,ANESTHESIA & OPERAT SERV,FT GORDON,GA 30905, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0003-3022 J9 ANESTHESIOLOGY JI Anesthesiology PD AUG PY 1992 VL 77 IS 2 BP 393 EP 394 DI 10.1097/00000542-199208000-00031 PG 2 WC Anesthesiology SC Anesthesiology GA JG533 UT WOS:A1992JG53300031 PM 1642363 ER PT J AU WALL, JG BURRIS, HA VONHOFF, DD RODRIGUEZ, G KNEUPERHALL, R SHAFFER, D OROURKE, T BROWN, T WEISS, G CLARK, G MCVEA, S BROWN, J JOHNSON, R FRIEDMAN, C SMITH, B MANN, WS KUHN, J AF WALL, JG BURRIS, HA VONHOFF, DD RODRIGUEZ, G KNEUPERHALL, R SHAFFER, D OROURKE, T BROWN, T WEISS, G CLARK, G MCVEA, S BROWN, J JOHNSON, R FRIEDMAN, C SMITH, B MANN, WS KUHN, J TI A PHASE-I CLINICAL AND PHARMACOKINETIC STUDY OF THE TOPOISOMERASE-I INHIBITOR TOPOTECAN (SK-AND-F-104864) GIVEN AS AN INTRAVENOUS BOLUS EVERY 21 DAYS SO ANTI-CANCER DRUGS LA English DT Article DE PHARMACOKINETIC STUDY; PHASE-1 TRIAL; TOPOISOMERASE-1 INHIBITOR; TOPOTECAN ID CAMPTOTHECIN NSC-100880; ANTITUMOR DRUGS; DNA; CANCER; CHEMOTHERAPY; CELLS AB Topotecan (SK&F 104864) is a novel antitumor agent whose mechanism of action is inhibition of the DNA unwinding protein topoisomerase I. An analog of camptothecin, topotecan was designed to be more water soluble in an effort to decrease the severe and sporadic toxicities experienced during phase I/II trials of the parent compound. In this phase I clinical and pharmacological trial, topotecan was given as a bolus intravenous (i.v.) infusion over 30 min every 21 days. A total of 42 patients entered the study, receiving doses ranging from 2.5 to 22.5 Mg/M2 . The maximum tolerated dose (MTD) of topotecan given in this schedule was 22.5 mg/m2. Myelo-suppression, primarily neutropenia, was dose-limiting. The extent of prior therapy did not predict for more severe neutropenia. Non-hematologic toxicities were mild and included low-grade to moderate fever, nausea, vomiting, alopecia, diarrhea and skin rashes. There were no objective partial or complete responses, although there was a suggestion of antitumor activity in three patients. Topotecan undergoes pH-dependent hydrolysis of the lactone ring; only the closed, lactone form is active. The lactone form predominated during infusion, with hydrolysis occurring rapidly following the end of infusion. There were linear relationships between dose administered and peak plasma lactone concentrations as well as AUC lactone to AUC total. The lactone was rapidly cleared from plasma with a total body clearance of 25.7 (+/-6.7) 1/h/M2 . The plasma lactone concentration declined rapidly with a harmonic mean terminal half-life of 3.4 (+/-1.1) h. Lactone hydrolysis and renal excretion were the major routes of elimination. Topotecan given as an i.v. bolus every 21 days proved to be a well-tolerated drug with primarily hematological toxicity. C1 UNIV TEXAS,HLTH SCI CTR,SAN ANTONIO,TX 78284. SMITHKLINE BEECHAM PHARMACEUT,PHILADELPHIA,PA. RP WALL, JG (reprint author), BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234, USA. FU NCI NIH HHS [CA-094343]; NCRR NIH HHS [RR-01346] NR 27 TC 112 Z9 112 U1 0 U2 0 PU RAPID SCIENCE PUBLISHERS PI LONDON PA 2-6 BOUNDARY ROW, LONDON, ENGLAND SE1 8NH SN 0959-4973 J9 ANTI-CANCER DRUG JI Anti-Cancer Drugs PD AUG PY 1992 VL 3 IS 4 BP 337 EP 345 DI 10.1097/00001813-199208000-00004 PG 9 WC Oncology; Pharmacology & Pharmacy SC Oncology; Pharmacology & Pharmacy GA JK614 UT WOS:A1992JK61400004 PM 1330081 ER PT J AU CLENDENNEN, TE ECHEVERRIA, P SAENGEUR, S KEES, ES BOSLEGO, JW WIGNALL, FS AF CLENDENNEN, TE ECHEVERRIA, P SAENGEUR, S KEES, ES BOSLEGO, JW WIGNALL, FS TI ANTIBIOTIC SUSCEPTIBILITY SURVEY OF NEISSERIA-GONORRHOEAE IN THAILAND SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID QUALITY-CONTROL GUIDELINES; INTERPRETIVE CRITERIA; ANTIMICROBIAL AGENTS; RESISTANCE; STANDARDIZATION; SPECTINOMYCIN; KOREA AB The antibiotic susceptibilities of Neisseria gonorrhoeae isolates obtained from patients attending sexually transmitted disease clinics in Cholburi and Bangkok, Thailand, were determined by agar dilution. Some 28.2% of isolates produced beta-lactamase. A total of 97.9% of beta-lactamase-positive and 51% of beta-lactamase-negative isolates tested were resistant to penicillin (MICs, greater-than-or-equal-to 2-mu-g/ml), 70% of isolates tested were resistant to tetracycline (MICs, greater-than-or-equal-to 2-mu-g/ml), and 91% of isolates tested were susceptible to spectinomycin (MICs, less-than-or-equal-to 64-mu-g/ml). The MICs for 90% of isolates for the other drugs tested were 2-mu-g/ml for erythromycin, 2-mu-g/ml for cefoxitin, 1-mu-g/ml for cefuroxime, 0.125-mu-g/ml for cefpodoxime, 0.06-mu-g/ml for cefotaxime, 0.25-mu-g/ml for ceftazidime, 0.03-mu-g/ml for ceftizoxime, 0.03-mu-g/ml for ceftriaxone, 0.03-mu-g/ml for cefixime, 0.06-mu-g/ml for aztreonam, 0.008-mu-g/ml for ciprofloxacin, 0.125-mu-g/ml for norfloxacin, and 0.075-mu-g/ml for ofloxacin. Fewer than 1.5% of isolates were resistant to the extended-spectrum cephalosporins tested. Some 0.3% or fewer isolates were resistant to broad-spectrum cephalosporins, fluoroquinolones, or the monobactam aztreonam. Antibiotic resistance among N. gonorrhoeae isolates from Cholburi and Bangkok in May 1990 appeared to be primarily limited to penicillin and tetracycline, which are no longer used to control gonorrhea. Spectinomycin, which has been in general use against gonorrhea in Thailand since 1983, has dwindling utility, with resistance at a level of 8.9%. C1 SEXUALLY TRANSMITTED DIS CLIN,CHOLBURI,THAILAND. ARMED FORCES RES INST MED SCI,BANGKOK,THAILAND. RP CLENDENNEN, TE (reprint author), USN,ENVIRONM & PREVENT MED UNIT 6,HONOLULU,HI 96860, USA. NR 16 TC 50 Z9 50 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD AUG PY 1992 VL 36 IS 8 BP 1682 EP 1687 PG 6 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA JG147 UT WOS:A1992JG14700018 PM 1416851 ER PT J AU FISHERHOCH, SP GBORIE, S PARKER, L HUGGINS, J AF FISHERHOCH, SP GBORIE, S PARKER, L HUGGINS, J TI UNEXPECTED ADVERSE REACTIONS DURING A CLINICAL-TRIAL IN RURAL WEST AFRICA SO ANTIVIRAL RESEARCH LA English DT Article DE SIDE EFFECT; RIBAVIRIN; LASSA FEVER; RIGOR ID ACQUIRED-IMMUNODEFICIENCY-SYNDROME; SYNCYTIAL VIRUS-INFECTION; HIGH-RISK PATIENTS; LASSA FEVER; INTRAVENOUS RIBAVIRIN; HEMORRHAGIC-FEVER; THERAPY; INFANTS AB Ribavirin has been used widely in various clinical trials, without significant adverse effects beyond reversible, mild anemia. Since 1978 intravenous ribavirin has been used to treat Lassa fever in a remote area of Eastern Sierra Leone, West Africa. In March 1991, brief episodes of rigors in patients receiving ribavirin were reported. An immediate investigation found that 27/3 patients (29%) had records in 1990/1991 of at least one episode, the strongest association being with survival of Lassa fever (P = 0.0001). The occurrence or number of rigors in an individual patient was unassociated with sex, age. weight, volume of loading dose, cumulative dose, administration of other drugs, use of intravenous lines or heparin traps. In a review of 12 years of ribavirin administration, 74/2117 injections sampled (3.5%) were associated with a record of rigors. Most occurred before 08.00 h (P <0.0001), between 0 and 30 min after injection, lasted 2-45 min, and clustered towards the end of the treatment course (P <0.0001). There was no association with drug lot or individual vials. Drug was being given as a bolus (< 1 min). Since slowing the infusion rate, no further episodes have been reported. Epidemiologic techniques are important tools in rapid assessment of unexpected events particularly when conducting trials in remote locations. C1 CTR DIS CONTROL,NATL CTR INFECT DIS,DIV VIRAL & RICKETTSIAL DIS,ATLANTA,GA 30333. LASSA FEVER RES PROJECT,SEGBWEMA,SIERRA LEONE. USA,MED RES INST INFECT DIS,DEPT ANTIVIRAL STUDIES,DIV VIROL,FREDERICK,MD 21701. NR 26 TC 19 Z9 21 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-3542 J9 ANTIVIR RES JI Antiviral Res. PD AUG PY 1992 VL 19 IS 2 BP 139 EP 147 DI 10.1016/0166-3542(92)90073-E PG 9 WC Pharmacology & Pharmacy; Virology SC Pharmacology & Pharmacy; Virology GA JP392 UT WOS:A1992JP39200005 PM 1444324 ER PT J AU NAIR, V USSERY, MA AF NAIR, V USSERY, MA TI NEW HYPOXANTHINE NUCLEOSIDES WITH RNA ANTIVIRAL ACTIVITY SO ANTIVIRAL RESEARCH LA English DT Article DE EXOTIC RNA VIRUS; HYPOXANTHINE NUCLEOSIDE; ANTIVIRAL ACTIVITY ID VIRUS; DEHYDROGENASE; INHIBITORS; FEVER AB A series of novel C-2 functionalized hypoxanthine and purine ribonucleosides have been synthesized and evaluated against exotic RNA viruses of the family or genus alpha, arena, flavi, and rhabdo. Both specific and broad-spectrum antiviral activities were discovered but only with hypoxanthine nucleosides. C1 USA,MED RES INST INFECT DIS,DIV VIROL,FREDERICK,MD 21701. RP NAIR, V (reprint author), UNIV IOWA,DEPT CHEM,415 CB,IOWA CITY,IA 52242, USA. NR 14 TC 20 Z9 21 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-3542 J9 ANTIVIR RES JI Antiviral Res. PD AUG PY 1992 VL 19 IS 2 BP 173 EP 178 DI 10.1016/0166-3542(92)90076-H PG 6 WC Pharmacology & Pharmacy; Virology SC Pharmacology & Pharmacy; Virology GA JP392 UT WOS:A1992JP39200008 PM 1444325 ER PT J AU MEISELMAN, HL AF MEISELMAN, HL TI METHODOLOGY AND THEORY IN HUMAN EATING RESEARCH SO APPETITE LA English DT Article ID NORMAL-WEIGHT; BEHAVIOR RP MEISELMAN, HL (reprint author), USA,NATICK RES DEV & ENGN CTR,ATTENT STRNC-Y,NATICK,MA 01760, USA. NR 24 TC 95 Z9 95 U1 3 U2 3 PU ACADEMIC PRESS LTD PI LONDON PA 24-28 OVAL RD, LONDON, ENGLAND NW1 7DX SN 0195-6663 J9 APPETITE JI Appetite PD AUG PY 1992 VL 19 IS 1 BP 49 EP 55 DI 10.1016/0195-6663(92)90235-X PG 7 WC Behavioral Sciences; Nutrition & Dietetics SC Behavioral Sciences; Nutrition & Dietetics GA JM474 UT WOS:A1992JM47400004 PM 1416936 ER PT J AU MEISELMAN, HL AF MEISELMAN, HL TI OBSTACLES TO STUDYING REAL PEOPLE EATING REAL MEALS IN REAL SITUATIONS - RESPONSE SO APPETITE LA English DT Note RP MEISELMAN, HL (reprint author), USA,NATICK RES DEV & ENGN CTR,NATICK,MA 01760, USA. NR 10 TC 18 Z9 18 U1 0 U2 2 PU ACADEMIC PRESS LTD PI LONDON PA 24-28 OVAL RD, LONDON, ENGLAND NW1 7DX SN 0195-6663 J9 APPETITE JI Appetite PD AUG PY 1992 VL 19 IS 1 BP 84 EP 86 DI 10.1016/0195-6663(92)90243-Y PG 3 WC Behavioral Sciences; Nutrition & Dietetics SC Behavioral Sciences; Nutrition & Dietetics GA JM474 UT WOS:A1992JM47400012 ER PT J AU MAGILL, AJ GASSER, RA OSTER, CN GROGL, M SUN, W AF MAGILL, AJ GASSER, RA OSTER, CN GROGL, M SUN, W TI VISCEROTROPIC LEISHMANIASIS IN PERSONS RETURNING FROM OPERATION-DESERT-STORM - 1990-1991 SO ARCHIVES OF DERMATOLOGY LA English DT Article ID VISCERAL LEISHMANIASIS; CUTANEOUS LEISHMANIASIS; REGION; AGENT C1 WALTER REED ARMY MED CTR,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307. WILLIAM BEAUMONT ARMY MED CTR,INFECT DIS SERV,EL PASO,TX 79920. CTR DIS CONTROL,NATL CTR INFECT DIS,DIV PARSIT DIS,ATLANTA,GA 30333. RP MAGILL, AJ (reprint author), WALTER REED ARMY MED CTR,INFECT DIS SERV,WASHINGTON,DC 20307, USA. NR 11 TC 2 Z9 2 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0003-987X J9 ARCH DERMATOL JI Arch. Dermatol. PD AUG PY 1992 VL 128 IS 8 BP 1033 EP 1034 PG 2 WC Dermatology SC Dermatology GA JH724 UT WOS:A1992JH72400001 ER PT J AU DOMLOGEHULTSCH, N BENSON, P GAMMON, WR YANCEY, KB AF DOMLOGEHULTSCH, N BENSON, P GAMMON, WR YANCEY, KB TI A BULLOUS SKIN-DISEASE PATIENT WITH AUTOANTIBODIES AGAINST SEPARATE EPITOPES IN 1 MOL/L SODIUM-CHLORIDE SPLIT SKIN SO ARCHIVES OF DERMATOLOGY LA English DT Article ID SYSTEMIC LUPUS-ERYTHEMATOSUS; PEMPHIGOID ANTIGEN; AUTO-ANTIGEN; IDENTIFICATION; ACQUISITA; ANTIBODIES; PROTEIN; COMPLEX; IMMUNOFLUORESCENCE; HEMIDESMOSOME AB Background.- We describe a patient with a subepidermal bullous skin disease associated with autoantibodies recognizing separate epitopes in 1 mol/L sodium chloride (NaCl) split skin. Observations.- Direct immunofluorescence microscopy showed deposits of immunoglobulins and C3 in a continuous pattern in the patient's epidermal basement membrane zone. Direct immunoelectron microscopy demonstrated thick deposits of IgG overlying the lamina lucida and the lamina densa in a unique pattern. The patient had circulating IgG anti-basement membrane zone antibodies that bound both sides of 1 mol/L NaCl split skin, exhibited at least a fourfold-higher titer against the dermal side of this test substrate, and bound basal keratinocyte hemidesmosomes as well as focal sites along the superior portion of the lamina densa on indirect immunoelectron microscopy. Affinity purification of anti-basement membrane zone antibodies against epidermal or dermal strips of 1 mol/L NaCl split skin yielded IgG that only bound the side of split skin from which it was eluted. The patient's serum contained IgG that immunoprecipitated and immunoblotted the 230- and 170-kd bullous pemphigoid antigens. Affinity purification of patient antibody against bullous pemphigoid antigen immobilized on nitrocellulose paper yielded IgG that bound only the epidermal side of 1 mol/L NaCl split skin. The patient showed no evidence of reactivity against type VII collagen by direct immunoelectron microscopy, indirect immunoelectron microscopy, or immunoblot. Conclusions.- This patient's bullous skin disease is associated with IgG anti-basement membrane zone antibodies with two specificities: one recognizing the bullous pemphigoid antigen in the epidermal side of 1 mol/L NaCl split skin, and another binding a distinct, yet presently unidentified, epitope in the superior aspect of the lamina densa. C1 UNIFORMED SERV UNIV HLTH SCI,DEPT DERMATOL,B4080,4301 JONES BRIDGE RD,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,DERMATOL SERV,WASHINGTON,DC 20307. UNIV N CAROLINA,SCH MED,DEPT DERMATOL,CHAPEL HILL,NC 27514. FU NIAMS NIH HHS [AR-37446, 5-RO1-AR-30475] NR 26 TC 8 Z9 8 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0003-987X J9 ARCH DERMATOL JI Arch. Dermatol. PD AUG PY 1992 VL 128 IS 8 BP 1096 EP 1101 DI 10.1001/archderm.128.8.1096 PG 6 WC Dermatology SC Dermatology GA JH724 UT WOS:A1992JH72400011 PM 1379792 ER PT J AU CROWLEY, JS WESENSTEN, N KAMIMORI, G DEVINE, J IWANYK, E BALKIN, T AF CROWLEY, JS WESENSTEN, N KAMIMORI, G DEVINE, J IWANYK, E BALKIN, T TI EFFECT OF HIGH TERRESTRIAL ALTITUDE AND SUPPLEMENTAL OXYGEN ON HUMAN-PERFORMANCE AND MOOD SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article ID ACUTE MOUNTAIN-SICKNESS; METERS; DEXAMETHASONE; STATES AB Sustained exposure to high terrestrial altitudes is associated with cognitive decrement, mood changes, and acute mountain sickness (AMS). Such impairment in aviators could be a safety hazard. Thirteen male soldiers, ages 19-24, ascended in 10 min from sea level to 4,300 m (simulated), and remained there 2.5 d. Four times per day, subjects completed a test battery consisting of nine cognitive tests, a mood scale, and an AMS questionnaire. During one test session per day, subjects breathed 35% oxygen instead of ambient air. Analysis revealed transient deficits on altitude day 1 for three cognitive tasks. Most tasks displayed a persistent training effect. Sick subjects' moods were more negative and their performance improvement less. On altitude day 1, oxygen administration improved performance on two cognitive tests and one mood subscale. Following rapid ascent to 4,300 m, performance is most affected during the first 8 h. Individuals affected by AMS tend to improve more slowly in performance and have more negative moods than those who feel well. C1 WALTER REED ARMY MED CTR,DIV NEUROPSYCHIAT,WASHINGTON,DC 20307. USA,INST ENVIRONM MED,NATICK,MA 01760. RP CROWLEY, JS (reprint author), USA,AEROMED RES LAB,FT RUCKER,AL 36362, USA. NR 26 TC 30 Z9 30 U1 0 U2 2 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD AUG PY 1992 VL 63 IS 8 BP 696 EP 701 PG 6 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA JH361 UT WOS:A1992JH36100007 PM 1510643 ER PT J AU RAYGADA, M SHAHAM, Y NESPOR, SM KANT, GJ GRUNBERG, NE AF RAYGADA, M SHAHAM, Y NESPOR, SM KANT, GJ GRUNBERG, NE TI EFFECT OF STRESS ON HYPOTHALAMIC INSULIN IN RATS SO BRAIN RESEARCH BULLETIN LA English DT Article DE INSULIN; HYPOTHALAMUS; STRESS; ACTH; CORTICOSTERONE PROLACTIN ID IMMOBILIZATION STRESS; INDUCED ANOREXIA; BODY-WEIGHT; FOOD-INTAKE; BRAIN; CORTICOSTERONE; METABOLISM; PROLACTIN; GLUCAGON; ACTH AB Four experiments examined the effects of stress on hypothalamic insulin and plasma hormones in rats. Two hours daily of immobilization (IM) stress for 2 and 4 days resulted in an increase in hypothalamic insulin. In contrast, 15 min of daily IM over 13 days or 48 h of continuous signalled shock avoidance did not alter hypothalamic insulin. These findings are interpreted to indicate that changes in hypothalamic insulin are part of the stress response. Possible reasons for the different effects of time and paradigm on the hypothalamic insulin responses to stress are discussed. Plasma insulin and glucose levels were not responsive to any of the stressors. Brief acute stress caused increases in the stress-responsive hormones ACTH, corticosterone, and prolactin, as expected, and these responses attenuated or disappeared with repeated or longer stress exposures. C1 UNIFORMED SERV UNIV HLTH SCI,DEPT MED PSYCHOL,4301 JONES BRIDGE RD,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,DEPT MED NEUROSCI,WASHINGTON,DC 20307. RI shaham, yavin/G-1306-2014 NR 32 TC 13 Z9 13 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0361-9230 J9 BRAIN RES BULL JI Brain Res. Bull. PD AUG PY 1992 VL 29 IS 2 BP 129 EP 134 DI 10.1016/0361-9230(92)90017-R PG 6 WC Neurosciences SC Neurosciences & Neurology GA JH887 UT WOS:A1992JH88700001 PM 1326377 ER PT J AU ADLER, M HINMAN, D HUDSON, CS AF ADLER, M HINMAN, D HUDSON, CS TI ROLE OF MUSCLE FASCICULATIONS IN THE GENERATION OF MYOPATHIES IN MAMMALIAN SKELETAL-MUSCLE SO BRAIN RESEARCH BULLETIN LA English DT Article DE RAT DIAPHRAGM; NEUROMUSCULAR JUNCTION; PYRIDOSTIGMINE; CHOLINESTERASE INHIBITION; MYOPATHY; TETRODOTOXIN ID NEUROMUSCULAR-JUNCTIONS; MEDIATED MYOPATHY; RAT; PYRIDOSTIGMINE; DIAPHRAGM; ACETYLCHOLINE; SOLEUS AB The myotoxicity of pyridostigmine bromide was investigated on rat diaphragm nerve-muscle preparations in vitro. Within 2 h of exposure to pyridostigmine (2-mu-M), diaphragm muscles exhibited ultrastructural alterations characterized by swelling of subjunctional mitochondria and disorganization of contractile proteins. These alterations developed both in the absence and presence of electrical stimulation of the phrenic nerve, and were accompanied by continuous muscle fasciculations. Pretreatment by tetrodotoxin suppressed both the muscle fasciculations and the appearance of myopathies. These findings suggest that fasciculations may be an important contributing factor in the development of anticholinesterase-induced myopathies. C1 COLORADO STATE UNIV,COLL VET MED & BIOMED SCI,DEPT ANAT & NEUROBIOL,FT COLLINS,CO 80523. RP ADLER, M (reprint author), USA,MED RES INST CHEM DEF,NEUROTOXICOL BRANCH,ABERDEEN PROVING GROUND,MD 21010, USA. NR 21 TC 7 Z9 7 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0361-9230 J9 BRAIN RES BULL JI Brain Res. Bull. PD AUG PY 1992 VL 29 IS 2 BP 179 EP 187 DI 10.1016/0361-9230(92)90024-R PG 9 WC Neurosciences SC Neurosciences & Neurology GA JH887 UT WOS:A1992JH88700008 PM 1525673 ER PT J AU HARGIS, JB ANDERSON, JR PROPERT, KJ GREEN, MR VANECHO, DA WEISS, RB AF HARGIS, JB ANDERSON, JR PROPERT, KJ GREEN, MR VANECHO, DA WEISS, RB TI PREDICTING GENITOURINARY TOXICITY IN PATIENTS RECEIVING CISPLATIN-BASED COMBINATION CHEMOTHERAPY - A CANCER AND LEUKEMIA GROUP-B STUDY SO CANCER CHEMOTHERAPY AND PHARMACOLOGY LA English DT Article DE CISPLATIN; GENITOURINARY TOXICITY; AGE-RELATED TOXICITY; CREATININE CLEARANCE ID CREATININE CLEARANCE; NEPHROTOXICITY AB Assessment of renal function prior to cisplatin chemotherapy has long been based on measurement of creatinine clearance by 24-hour urine collection (CrC(meas)). Estimated creatinine clearance (CrC(est)) as calculated from the patient's age, weight, and serum creatinine level has been suggested as an adequate surrogate for CrC(meas), as it provides advantages of improved convenience, decreased cost, and possibly increased accuracy. We studied 847 patients receiving cisplatin-based chemotherapy on Cancer and Leukemia Group B (CALGB) protocols to determine whether the CrC(meas), CrC(est), or serum creatinine value or the age of the patient would predict the subsequent genitourinary (GU) toxicity. Both CrC(meas) (P = 0.001) and CrC(est) (P = 0.02) were predictive of subsequent grade 2+ GU toxicity, with CrC(meas) being a slightly better predictor. Patient age also influenced subsequent GU toxicity, with the risk increasing with age (P = 0.0008). When patients were classified by age group and by CrC(meas), distinct subgroups were identified, with differences in the risk for grade 2+ GU toxicity ranging from 14% to 32%. Using a logistic model to assess the probability of grade 2+ GU toxicity, we found that an age of greater-than-or-equal-to 60 years (P = 0.005), a CrC(meas) value of < 75 ml/min (P = 0.004), and the risk characteristics of the individual cisplatin trial were important, whereas CrC(est) was not. Furthermore, CrC(est) proved to be a poor predictor of a CrC(meas) value of < 75 ml/min, "misclassifying" nearly half of the patients to a "lower-risk" subgroup. In summary, both CrC(meas) and the patient's age independently provided predictive information concerning cisplatin GU toxicity. Our data support the continued clinical usefulness of determining the CrC(meas) value prior to the administration of cisplatin-based chemotherapy to most patients. C1 UNIFORMED SERV UNIV HLTH SCI,DEPT MED,BETHESDA,MD 20814. UNIV NEBRASKA,DEPT PREVENT & SOCIETAL MED,OMAHA,NE 68182. HARVARD UNIV,SCH PUBL HLTH,BOSTON,MA 02115. UNIV CALIF SAN DIEGO,CTR CANC,SAN DIEGO,CA 92103. UNIV MARYLAND,CTR CANC,BALTIMORE,MD 21201. RP HARGIS, JB (reprint author), WALTER REED ARMY MED CTR,HEMATOL ONCOL SERV,WASHINGTON,DC 20307, USA. FU NCI NIH HHS [CA 11789, CA 26806, CA 33601] NR 17 TC 6 Z9 6 U1 0 U2 0 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0344-5704 J9 CANCER CHEMOTH PHARM JI Cancer Chemother. Pharmacol. PD AUG PY 1992 VL 30 IS 4 BP 291 EP 296 DI 10.1007/BF00686298 PG 6 WC Oncology; Pharmacology & Pharmacy SC Oncology; Pharmacology & Pharmacy GA JF451 UT WOS:A1992JF45100008 PM 1643697 ER PT J AU ELIASSON, AH PHILLIPS, YY RAJAGOPAL, KR HOWARD, RS AF ELIASSON, AH PHILLIPS, YY RAJAGOPAL, KR HOWARD, RS TI SENSITIVITY AND SPECIFICITY OF BRONCHIAL PROVOCATION TESTING - AN EVALUATION OF 4 TECHNIQUES IN EXERCISE-INDUCED BRONCHOSPASM SO CHEST LA English DT Article ID EUCAPNIC VOLUNTARY HYPERVENTILATION; COLD AIR; ISOCAPNIC HYPERVENTILATION; ASTHMATIC SUBJECTS; DISTILLED WATER; METHACHOLINE; INHALATION; CHALLENGE; RESPONSIVENESS; RESPONSES AB The thresholds used to define a positive result for bronchial provocation challenges (BPC) are arbitrary. Requiring smaller decrements in expired flow to define a positive study would capture more cases of reactive airways (increased sensitivity) but would include some "normal" responses (decreased specificity). To examine the relationship between threshold definition and the ability to correctly classify subjects as either normal or as having airways hyperresponsiveness (AHR), four different BPC tests were administered on different days to 20 patients with a clinical diagnosis of exercise-induced bronchospasm (EIB) and 20 control subjects. The four BPC tests were indoor exercise on a cycle ergometer, methacholine inhalation challenge (MIC), eucapnic voluntary hyperventilation (EVH) with dry gas, and EVH with cold gas. Our results indicate that the thresholds which best separate the two groups are different for each of the four BPC techniques. For methacholine inhalation (MIC), a fall in FEV1 (d%FEV1) of 15 percent or greater at 188 cumulative breath units was 100 percent specific for AHR but had a sensitivity of only 55 percent. Eucapnic voluntary hyperventilation (EVH) with room temperature dry gas was 100 percent specific at a d%FEV1 of 11 percent, but, at that threshold, sensitivity was only 50 percent. EVH with cold air was 100 percent specific at a d%FEV1 of 12 percent but sensitivity was only 35 percent. The bicycle ergometer challenge was far too insensitive to be of value in evaluating AHR. Based on their respective receiver operating characteristic curves, the best separation of the two subject groups occurred at a d%FEV1 of 5 percent and 12 percent for the two EVH techniques and MIC, respectively. An individual's response to one test was highly correlated with the response to either of the other two (r=0.66, p<0.001 for dry vs cold gas EVH; r=0.56, p<0.001 for dry gas EVH vs methacholine; and r=0.69, p<0.001 for cold gas EVH vs methacholine). Thus, MIC and EVH techniques are equally useful in defining AHR and each has its optimal threshold for a positive test result. C1 WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,DEPT MED,BETHESDA,MD 20814. RP ELIASSON, AH (reprint author), WALTER REED ARMY MED CTR,DEPT MED,PULM & CRIT CARE MED SERV,WASHINGTON,DC 20307, USA. NR 35 TC 116 Z9 117 U1 0 U2 3 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 SN 0012-3692 J9 CHEST JI Chest PD AUG PY 1992 VL 102 IS 2 BP 347 EP 355 DI 10.1378/chest.102.2.347 PG 9 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA JH513 UT WOS:A1992JH51300008 PM 1643912 ER PT J AU ELIASSON, AH PHILLIPS, YY STAJDUHAR, KC CAROME, MA COWSAR, JD AF ELIASSON, AH PHILLIPS, YY STAJDUHAR, KC CAROME, MA COWSAR, JD TI OXYGEN-CONSUMPTION AND VENTILATION DURING NORMAL LABOR SO CHEST LA English DT Article ID NORMAL WOMEN; PREGNANCY; DISEASE; EXERCISE; LUNG AB Oxygen consumption (VO2) and minute ventilation (VE) were measured breath-by-breath for 10-min periods in the third trimester of pregnancy in 16 healthy women. These measurements were repeated during the first stage of labor in eight of the women. The 10-min mean VO2 was 3.56 ml/kg/min (+/-0.82 SD) at term and 4.28 ml/kg/min (0.93) during labor, for an average increase of 23 percent (+/-28 percent, p=0.04) from third trimester to labor. The mean VE was 0.15 L/kg/min (+/-0.03) at term and increased significantly (p=0.05) to 0.24 L/kg/min (+/-0.11) during labor for an average increase in VE of 65 percent (+/-78 percent). Peak VO2 and VE occurred during contractions with five-breath average peak VO2 being 86 percent (+/-53%) above the 10-min mean value at term and VE increasing 167 percent (+/-154 percent) from third trimester to peak values during labor. These data may be useful in identifying patients at risk for developing respiratory insufficiency during labor. We propose an algorithm for approaching the obstetric patient with respiratory disease. C1 WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. DEWITT ARMY COMMUNITY HOSP,DEPT FAMILY PRACTICE,FT BELVOIR,VA. UNIFORMED SERV UNIV HLTH SCI,DEPT MED,BETHESDA,MD 20814. RP ELIASSON, AH (reprint author), WALTER REED ARMY MED CTR,DEPT MED,WASHINGTON,DC 20307, USA. NR 20 TC 10 Z9 10 U1 0 U2 1 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 SN 0012-3692 J9 CHEST JI Chest PD AUG PY 1992 VL 102 IS 2 BP 467 EP 471 DI 10.1378/chest.102.2.467 PG 5 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA JH513 UT WOS:A1992JH51300030 PM 1643934 ER PT J AU MORRIS, JT SEAWORTH, BJ MCALLISTER, CK AF MORRIS, JT SEAWORTH, BJ MCALLISTER, CK TI PULMONARY TUBERCULOSIS IN DIABETICS SO CHEST LA English DT Article AB Pulmonary tuberculosis is found predominantly in the lung apices. In diabetics it has been suggested that tuberculosis tended to occur predominantly in the lower lobes. A retrospective chart review was performed of all patients with a diagnosis of diabetes and pulmonary tuberculosis admitted to a health care facility to determine the presenting chest roentgenographic location of tuberculosis. Multiple lobe involvement was the predominant chest roentgenographic finding in both diabetics and nondiabetics with pulmonary tuberculosis. Since tuberculosis and diabetes frequently coexist in the population at risk for tuberculosis, clinicians should suspect tuberculosis in the diabetic with an abnormality on chest roentgenogram. Aggressive diagnostic measures and specific chemotherapy should be given and monitored to treat pulmonary tuberculosis. C1 SAN ANTONIA STATE CHEST HOSP,SAN ANTONIO,TX. RP MORRIS, JT (reprint author), BROOKE ARMY MED CTR,SERV INFECT DIS,FT SAM HOUSTON,TX 78234, USA. NR 4 TC 26 Z9 28 U1 0 U2 0 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 SN 0012-3692 J9 CHEST JI Chest PD AUG PY 1992 VL 102 IS 2 BP 539 EP 541 DI 10.1378/chest.102.2.539 PG 3 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA JH513 UT WOS:A1992JH51300045 PM 1643944 ER PT J AU PELLER, PJ ANDERSON, JH AF PELLER, PJ ANDERSON, JH TI TRANSIENT DIAPHYSEAL TIBIAL TC-99M MDP UPTAKE AND BONE-MARROW EDEMA IN ACUTE RHEUMATIC-FEVER SO CLINICAL NUCLEAR MEDICINE LA English DT Article ID UNITED-STATES; OSTEOPOROSIS; RESURGENCE; DISEASE; RISE; FALL; AREA AB The authors describe a patient with acute rheumatic fever and polyarthritis in whom scintigraphy unexpectantly identified Tc-99m MDP uptake in the diaphyses of both tibiae. A dramatic rise in antistreptolysin-O titer and rapid resolution of tibial abnormalities paralleled marked articular improvement. Magnetic resonance imaging demonstrated a pattern consistent with marrow edema in the area of abnormal Tc-99m MDP accumulation. This finding has not been previously described in acute rheumatic fever, and it was suspected that the changes in the tibiae resulted from subclinical diaphyseal hyperemia from the inflammatory process observed in the contiguous joints. RP PELLER, PJ (reprint author), WALTER REED ARMY MED CTR,NUCL MED SERV,DEPT RADIOL,6825 16TH ST NW,WASHINGTON,DC 20307, USA. NR 19 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0363-9762 J9 CLIN NUCL MED JI Clin. Nucl. Med. PD AUG PY 1992 VL 17 IS 8 BP 634 EP 637 DI 10.1097/00003072-199208000-00005 PG 4 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA JG693 UT WOS:A1992JG69300005 PM 1505128 ER PT J AU CORTESE, LM BJORNSON, DC AF CORTESE, LM BJORNSON, DC TI POTENTIAL INTERACTION BETWEEN TERFENADINE AND MACROLIDE ANTIBIOTICS SO CLINICAL PHARMACY LA English DT Letter RP CORTESE, LM (reprint author), WALTER REED ARMY MED CTR,HENRY M JACKSON FDN,BLDG 1,WARD 11,WASHINGTON,DC 20307, USA. NR 0 TC 2 Z9 2 U1 0 U2 0 PU AMER SOC HEALTH-SYSTEM PHARMACISTS PI BETHESDA PA 7272 WISCONSIN AVE, BETHESDA, MD 20814 SN 0278-2677 J9 CLIN PHARMACY PD AUG PY 1992 VL 11 IS 8 BP 675 EP 675 PG 1 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA JE602 UT WOS:A1992JE60200005 PM 1511540 ER PT J AU TEZDUYAR, TE BEHR, M ALIABADI, SK MITTAL, S RAY, SE AF TEZDUYAR, TE BEHR, M ALIABADI, SK MITTAL, S RAY, SE TI A NEW MIXED PRECONDITIONING METHOD FOR FINITE-ELEMENT COMPUTATIONS SO COMPUTER METHODS IN APPLIED MECHANICS AND ENGINEERING LA English DT Article ID ALGORITHM; SYSTEMS; GMRES AB A new mixed clustered element-by-element (CEBE)/cluster companion (CC) preconditioning method for finite element computations is introduced. In the CEBE preconditioning, the elements are merged into clusters of elements, and the preconditioners are defined as series products of cluster level matrices. The CC preconditioning method, which is also introduced in this paper, shares a common philosophy with the multi-grid methods. The CC preconditioners are based on companion meshes associated with different levels of clustering. For each level of clustering, we construct a CEBE preconditioner and an associated CC preconditioner. Because these two preconditioners in a sense complement each other, when they are used in a mixed way, they can be expected to give better performance. In fact, our numerical tests, for two- and three-dimensional problems governed by the Poisson equation, demonstrate that the mixed CEBE/CC preconditioning results in convergence rates which are, in most cases, significantly better than the convergence rates obtained with the best of the CEBE and CC preconditioning methods. C1 UNIV MINNESOTA,USA,HIGH PERFORMANCE COMP RES CTR,MINNEAPOLIS,MN 55415. RP TEZDUYAR, TE (reprint author), UNIV MINNESOTA,MINNESOTA SUPERCOMP INST,DEPT AEROSP ENGN & MECH,1200 WASHINGTON AVE S,MINNEAPOLIS,MN 55415, USA. RI Behr, Marek/H-5401-2011; Tezduyar, Tayfun/F-6134-2012 OI Behr, Marek/0000-0003-4257-8276; Tezduyar, Tayfun/0000-0001-8707-3162 NR 14 TC 23 Z9 23 U1 0 U2 0 PU ELSEVIER SCIENCE SA LAUSANNE PI LAUSANNE 1 PA PO BOX 564, 1001 LAUSANNE 1, SWITZERLAND SN 0045-7825 J9 COMPUT METHOD APPL M JI Comput. Meth. Appl. Mech. Eng. PD AUG PY 1992 VL 99 IS 1 BP 27 EP 42 DI 10.1016/0045-7825(92)90121-Y PG 16 WC Engineering, Multidisciplinary; Mathematics, Interdisciplinary Applications; Mechanics SC Engineering; Mathematics; Mechanics GA JR268 UT WOS:A1992JR26800002 ER PT J AU ASCHER, DP SHOUPE, BA ROBB, M MAYBEE, DA FISCHER, GW AF ASCHER, DP SHOUPE, BA ROBB, M MAYBEE, DA FISCHER, GW TI COMPARISON OF STANDARD AND QUANTITATIVE BLOOD CULTURES IN THE EVALUATION OF CHILDREN WITH SUSPECTED CENTRAL VENOUS LINE SEPSIS SO DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE LA English DT Article ID 1.5 MICROBIAL TUBE; LYSIS-CENTRIFUGATION; CLINICAL-EVALUATION; SYSTEM; BACTEREMIA; SEPTICEMIA AB We reviewed our experience with paired quantitative and standard blood cultures in the evaluation of children with suspected central-line sepsis with the hypothesis that by employing both systems we would increase our yield of pathogenic isolates. A total of 913 paired cultures were reviewed, representing 267 pathogenic isolates and 58 individual episodes of sepsis. The isolates were analyzed for recovery rates for each system and by combining both systems. The Isolator system proved to be equal to the BACTEC system for the recovery of all groups of pathogenic isolates. The combined use of both the quantitative and the standard culture systems demonstrated a statistically significant advantage (p<0.001) for the recovery of pathogens as compared with either system alone. The use of either system alone would have missed 15% of the total pathogenic isolates. Quantitative colony counts were helpful in identifying the line as the source of infection in 35 to 58 episodes of sepsis and were often beneficial in the clinical management central venous line infection. We recommend the use of the Isolator 1.5 ml combined with a conventional broth-bottle system in selected pediatric patients to enhance the recovery of pathogenic organisms. C1 UNIFORMED SERV UNIV HLTH SCI,DEPT PEDIAT,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,DEPT PEDIAT INFECT DIS,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT PEDIAT HEMATOL ONCOL,WASHINGTON,DC 20307. NR 20 TC 6 Z9 6 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0732-8893 J9 DIAGN MICR INFEC DIS JI Diagn. Microbiol. Infect. Dis. PD AUG PY 1992 VL 15 IS 6 BP 499 EP 503 DI 10.1016/0732-8893(92)90098-E PG 5 WC Infectious Diseases; Microbiology SC Infectious Diseases; Microbiology GA JG245 UT WOS:A1992JG24500002 PM 1424502 ER PT J AU ROBIER, TC FABRY, DA LEEK, MR VANSUMMERS, W AF ROBIER, TC FABRY, DA LEEK, MR VANSUMMERS, W TI IMPROVING THE FREQUENCY SPECIFICITY OF THE AUDITORY BRAIN-STEM RESPONSE SO EAR AND HEARING LA English DT Article ID PURE-TONE AUDIOGRAM; AUDIOMETRY; STIMULI AB Several investigators have suggested that the use of tonal stimuli shaped with nonlinear windowing functions can improve the frequency specificity of the auditory brain stem response (ABR). This study investigated the effects of different windowing functions on the ABR for 30 normal-hearing adults and 30 adults with high-frequency hearing loss. These hearing-impaired patients often produce an abnormal click-evoked ABR because of the influence of the high-frequency loss. Each subject was evaluated using a click stimulus and a 500 Hz tone burst gated with one linear and four nonlinear windowing functions. There were no significant differences in wave V latency between the groups for any of the five windowed tone burst conditions. These results suggest that any of the windowing functions used would be effective for 500 Hz tonal ABRs with this population of hearing-impaired adults. RP ROBIER, TC (reprint author), WALTER REED ARMY MED CTR,ARMY AUDIOL & SPEECH CTR,WASHINGTON,DC 20307, USA. NR 16 TC 4 Z9 6 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0196-0202 J9 EAR HEARING JI Ear Hear. PD AUG PY 1992 VL 13 IS 4 BP 223 EP 227 DI 10.1097/00003446-199208000-00002 PG 5 WC Audiology & Speech-Language Pathology; Otorhinolaryngology SC Audiology & Speech-Language Pathology; Otorhinolaryngology GA JK060 UT WOS:A1992JK06000002 PM 1397763 ER PT J AU BARRILLEAUX, CN CARROUGHER, JG AF BARRILLEAUX, CN CARROUGHER, JG TI RUSSELL PERCUTANEOUS ENDOSCOPIC GASTROSTOMY TECHNIQUE AS SACKS-VINE SALVAGE OPTION SO ENDOSCOPY LA English DT Letter C1 BROOKE ARMY MED CTR,DEPT MED,FT SAM HOUSTON,TX 78234. RP BARRILLEAUX, CN (reprint author), MAHORNER CLIN,GASTROENTEROL SECT,708 W ESPLANADE AVE,METAIRIE,LA 70065, USA. NR 2 TC 0 Z9 0 U1 0 U2 0 PU GEORG THIEME VERLAG PI STUTTGART PA P O BOX 30 11 20, D-70451 STUTTGART, GERMANY SN 0013-726X J9 ENDOSCOPY JI Endoscopy PD AUG PY 1992 VL 24 IS 6 BP 600 EP 601 DI 10.1055/s-2007-1010555 PG 2 WC Gastroenterology & Hepatology; Surgery SC Gastroenterology & Hepatology; Surgery GA JR060 UT WOS:A1992JR06000013 PM 1396373 ER PT J AU HEWITT, AD CRAGIN, JH AF HEWITT, AD CRAGIN, JH TI FORMIC AND ACETIC-ACIDS IN COASTAL NORTH-CAROLINA RAINWATER - COMMENT SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Letter RP HEWITT, AD (reprint author), COLD REG RES & ENGN LAB,HANOVER,NH 03755, USA. NR 3 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0013-936X J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD AUG PY 1992 VL 26 IS 8 BP 1666 EP 1666 DI 10.1021/es00032a029 PG 1 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA JF520 UT WOS:A1992JF52000034 ER PT J AU KELLY, NM CROSS, AS AF KELLY, NM CROSS, AS TI INTERLEUKIN-6 IS A BETTER MARKER OF LETHALITY THAN TUMOR-NECROSIS-FACTOR IN ENDOTOXIN TREATED MICE SO FEMS MICROBIOLOGY IMMUNOLOGY LA English DT Article DE TUMOR NECROSIS FACTOR; INTERLEUKIN-6; ENDOTOXEMIA ID ESCHERICHIA-COLI; GROWTH-FACTOR; HYBRIDOMA; CYTOKINES; SHOCK AB We established a mouse model to differentiate between a lethal and non-lethal presentation of endotoxic shock. The model involved injecting different amounts of Escherichia coli LPS into C3H/HeN mice which had been 'primed' with BCG. We found that the mice receiving non-lethal and lethal doses of LPS could not be differentiated in terms of their physical symptoms for the first 8 h post-injection. Tumour necrosis factor (TNF) was detected at concentrations 2-9-fold greater in mice receiving lethal doses of LPS when compared with non-lethally injected mice. However, given that (i) the successful detection of this differential was dependent on the time of sampling and (ii) that TNF was only detected in the first 3-4 h post LPS challenge, we suggest that TNF may not be very useful as a prognostic marker in endotoxic shock. In contrast, circulating IL-6 appeared to mirror the symptoms of the endotoxic mice. The relative disappearance of IL-6 after 10 h in the non-lethally injected mice corresponded with their symptomatic recovery, while IL-6 continued to circulate up to the time of death in the lethally injected mice. Furthermore, there appeared to be a good correlation between the levels of injected LPS and the levels of IL-6 induced into the circulation. Our results suggest that IL-6, rather than TNF, may serve as a prognostic marker for endotoxic shock. C1 WALTER REED ARMY MED CTR,DEPT BACTERIAL DIS,WASHINGTON,DC 20307. NR 16 TC 16 Z9 16 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0920-8534 J9 FEMS MICROBIOL IMMUN PD AUG PY 1992 VL 89 IS 6 BP 317 EP 322 DI 10.1111/j.1574-6968.1992.tb05011.x PG 6 WC Immunology; Microbiology SC Immunology; Microbiology GA JK881 UT WOS:A1992JK88100003 PM 1524837 ER PT J AU TONEY, MO LANDRY, A SMITH, T AF TONEY, MO LANDRY, A SMITH, T TI EXCRETION OF TL-204 IN HUMAN BREAST-MILK SO HEALTH PHYSICS LA English DT Letter RP TONEY, MO (reprint author), BROOKE ARMY MED CTR, NUCL MED SERV, FT SAM HOUSTON, TX 78234 USA. NR 1 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0017-9078 EI 1538-5159 J9 HEALTH PHYS JI Health Phys. PD AUG PY 1992 VL 63 IS 2 BP 234 EP 234 PG 1 WC Environmental Sciences; Public, Environmental & Occupational Health; Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical Imaging SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical Imaging GA JE630 UT WOS:A1992JE63000017 PM 1399626 ER PT J AU HILL, SG IAVECCHIA, HP BYERS, JC BITTNER, AC ZAKLAD, AL CHRIST, RE AF HILL, SG IAVECCHIA, HP BYERS, JC BITTNER, AC ZAKLAD, AL CHRIST, RE TI COMPARISON OF 4 SUBJECTIVE WORKLOAD RATING-SCALES SO HUMAN FACTORS LA English DT Article AB Four subjective workload scales were compared along four dimensions: sensitivity, operator acceptance, resource requirements, and special procedures. The scales were the Modified Cooper-Harper scale, the National Aeronautics and Space Administration Task Load Index (TLX), the Overall Workload (OW) scale, and the Subjective Workload Assessment Technique. Three U.S. Army systems were studied for potential workload concerns. Data from five different studies on the three systems were compared along the aforementioned four dimensions. Results indicate that all four scales are acceptable tools and are sensitive to different levels of workload. However, TLX and OW are consistently superior when considering sensitivity, as measured by factor validity, and operator acceptance. This research is an example of a systematic approach for examining human factors measurement tools. C1 COMP SCI CORP,MOORESTOWN,NJ. BATTELLE HUMAN AFFAIRS RES CTR,SEATTLE,WA. CHI SYST,SPRING HOUSE,PA. USA,RES INST,FT BLISS,TX. RP HILL, SG (reprint author), EG&G IDAHO INC,IDAHO NATL ENGN LAB,HUMAN FACTORS RES UNIT,POB 1625,IDAHO FALLS,ID 83415, USA. NR 25 TC 110 Z9 121 U1 1 U2 11 PU HUMAN FACTORS SOC PI SANTA MONICA PA BOX 1369, SANTA MONICA, CA 90406 SN 0018-7208 J9 HUM FACTORS JI Hum. Factors PD AUG PY 1992 VL 34 IS 4 BP 429 EP 439 PG 11 WC Behavioral Sciences; Engineering, Industrial; Ergonomics; Psychology, Applied; Psychology SC Behavioral Sciences; Engineering; Psychology GA JK876 UT WOS:A1992JK87600005 ER PT J AU TRAUPE, H MULLER, D ATHERTON, D KALTER, DC CREMERS, FPM VANOOST, BA ROPERS, HH AF TRAUPE, H MULLER, D ATHERTON, D KALTER, DC CREMERS, FPM VANOOST, BA ROPERS, HH TI EXCLUSION MAPPING OF THE X-LINKED DOMINANT CHONDRODYSPLASIA PUNCTATA ICHTHYOSIS CATARACT SHORT STATURE (HAPPLE) SYNDROME - POSSIBLE INVOLVEMENT OF AN UNSTABLE PREMUTATION SO HUMAN GENETICS LA English DT Article ID CONRADI-HUNERMANN SYNDROME; INCONTINENTIA-PIGMENTI; GENETIC-HETEROGENEITY; DINUCLEOTIDE REPEAT; TUBEROUS SCLEROSIS; CHROMOSOME; DNA; DELETION; FAMILY; REGION AB Homology with the mouse bare patches mutant suggests that the gene for the X-linked dominant chondrodysplasia punctata / ichthyosis / cataract / short stature syndrome (Happle syndrome) is located in the human Xq28 region. To test this hypothesis, we performed a linkage study in three families comprising a total of 12 informative meioses. Multiple recombinations appear to exclude the Xq28 region as the site of the gene. Surprisingly, multiple crossovers were also found with 26 other markers spread along the rest of the X chromosome. Two-point linkage analysis and analysis of recombination chromosomes seem to exclude the gene from the entire X chromosome. Three different mechanisms are discussed that could explain the apparent exclusion of an X-linked gene from the X chromosome by linkage analysis: (a) different mutations on the X chromosome disturbing X inactivation, (b) metabolic interference, i.e. allele incompatibility of an X-linked gene, and (c) an unstable pre-mutation that can become silent in males. We favour the last explanation. as it would account for the unexpected sex ratio (M:F) of 1.2:1 among surviving siblings, and for the striking clinical variability of the phenotype, including stepwise increases in disease expression in successive generations. C1 UNIV HOSP NIJMEGEN,DEPT HUMAN GENET,6500 HB NIJMEGEN,NETHERLANDS. HOSP SICK INFANTS,O-9091 KARL MARX STADT,GERMANY. MUNICIPAL HOSP,CTR CLIN GENET,O-9091 KARL MARX STADT,GERMANY. HOSP SICK CHILDREN,PEDIAT DERMATOL UNIT,LONDON WC1N 3JH,ENGLAND. WALTER REED ARMY MED CTR,DEPT DERMATOL,WASHINGTON,DC 20307. RP TRAUPE, H (reprint author), UNIV MUNSTER,ZENTRUM DERMATOL,VON ESMARCH STR 56,W-4400 MUNSTER,GERMANY. RI Cremers, Frans/A-5625-2014 NR 40 TC 38 Z9 38 U1 0 U2 0 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0340-6717 J9 HUM GENET JI Hum. Genet. PD AUG PY 1992 VL 89 IS 6 BP 659 EP 665 PG 7 WC Genetics & Heredity SC Genetics & Heredity GA JK151 UT WOS:A1992JK15100017 PM 1355069 ER PT J AU TORRIERI, D BAKHRU, K AF TORRIERI, D BAKHRU, K TI THE RECURSIVE SUPPRESSION ALGORITHM FOR ADAPTIVE SUPERRESOLUTION SO IEEE TRANSACTIONS ON ANTENNAS AND PROPAGATION LA English DT Article AB The recursive suppression algorithm is an adaptive algorithm that is one of the simplest superresolution algorithms to implement but, nevertheless, converges approximately as rapidly as the computationally intensive MUSIC algorithm. Simulation results verify the effectiveness of this algorithm in resolving closely spaced signals. Necessary and sufficient conditions for the convergence of the mean weight vector in the recursive suppression algorithm are derived. C1 CUBIC CORP,CUBIC DEF SYST,SYST ENGN GRP,SAN DIEGO,CA 92123. RP TORRIERI, D (reprint author), USA,SURVIVABIL MANAGEMENT OFF,2800 POWDER HILL RD,ADELPHI,MD 20783, USA. NR 7 TC 2 Z9 2 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-926X J9 IEEE T ANTENN PROPAG JI IEEE Trans. Antennas Propag. PD AUG PY 1992 VL 40 IS 8 BP 926 EP 932 DI 10.1109/8.163430 PG 7 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA JT921 UT WOS:A1992JT92100008 ER PT J AU MADJAR, A HERCZFELD, PR PAOLELLA, A AF MADJAR, A HERCZFELD, PR PAOLELLA, A TI ANALYTICAL MODEL FOR OPTICALLY GENERATED CURRENTS IN GAAS-MESFETS SO IEEE TRANSACTIONS ON MICROWAVE THEORY AND TECHNIQUES LA English DT Article ID FET AB The MESFET as an optically sensitive microwave element on MMIC's has attracted much attention. The theoretical modelling of the device, however, needs more consideration. This paper proposes an analytical model for the illuminated MESFET, complete in that all major contributions to the optical response are considered. The dependence of the response on bias conditions, the wavelength and intensity of the optical input, and the particulars of device structure, are incorporated in the model. The importance of the internal photovoltaic effect, which has not been properly modelled previously, is emphasized. The novel theoretical model is verified by experimental results. C1 USA,LABCOM,ELECTR TECHNOL & DEVICES LAB,FT MONMOUTH,NJ 07703. RP MADJAR, A (reprint author), DREXEL UNIV,CTR MICROWAVE LIGHTWAVE ENGN,PHILADELPHIA,PA 19104, USA. NR 21 TC 51 Z9 51 U1 0 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9480 J9 IEEE T MICROW THEORY JI IEEE Trans. Microw. Theory Tech. PD AUG PY 1992 VL 40 IS 8 BP 1681 EP 1691 DI 10.1109/22.149548 PG 11 WC Engineering, Electrical & Electronic SC Engineering GA JG713 UT WOS:A1992JG71300011 ER PT J AU HAMBURGER, KE AF HAMBURGER, KE TI THE FRAMEWORK OF OPERATIONAL WARFARE - NEWELL,CR SO INTERNATIONAL HISTORY REVIEW LA English DT Book Review RP HAMBURGER, KE (reprint author), US MIL ACAD,W POINT,NY 10996, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SIMON FRASER UNIV, INT HISTORY REVIEW PI BURNABY PA EAA 2015, BURNABY BC V5A 1S6, CANADA SN 0707-5332 J9 INT HIST REV JI Int. Hist. Rev. PD AUG PY 1992 VL 14 IS 3 BP 652 EP 654 PG 3 WC History SC History GA JL121 UT WOS:A1992JL12100071 ER PT J AU VATS, T BUCHANAN, G MEHTA, P RAGAB, A HVIZDALE, E NITSCHKE, R LINK, M BEARDSLEY, GP MAYBEE, D KRISCHER, J AF VATS, T BUCHANAN, G MEHTA, P RAGAB, A HVIZDALE, E NITSCHKE, R LINK, M BEARDSLEY, GP MAYBEE, D KRISCHER, J TI A STUDY OF TOXICITY AND COMPARATIVE THERAPEUTIC EFFICACY OF VINDESINE-PREDNISONE VS VINCRISTINE-PREDNISONE IN CHILDREN WITH ACUTE LYMPHOBLASTIC-LEUKEMIA IN RELAPSE - A PEDIATRIC ONCOLOGY GROUP-STUDY SO INVESTIGATIONAL NEW DRUGS LA English DT Article DE VINDESINE; VINCRISTINE; ACUTE LYMPHOBLASTIC LEUKEMIA; RELAPSE ID ACUTE LYMPHOCYTIC-LEUKEMIA; REMISSION INDUCTION; CROSS-RESISTANCE AB Vindesine (des-acetyl Vinblastine) is a synthetic derivative of vinblastine, and was produced with the hope that it would have less neurotoxicity and hematopoietic toxicity than other vinca alkaloids. Phase I and II studies also demonstrated significant activity in lymphoid malignancies, especially Acute Lymphoblastic Leukemia (ALL). The present study was designed to compare therapeutic effectiveness of twice weekly vindesine (2 mg/M2/dose) plus Prednisone (60 mg/M2/dose) (Treatment 1) to weekly Vincristine (2 mg/M2/dose) plus Prednisone (60 mg/M2/day) (Treatment 2). All patients were less than 21 years of age, and had documented bone marrow relapse (blast count > 25%). In 39 patients presumed sensitive to vincristine, there were 11 complete responses out of 20 patients (55%) randomized to receive vindesine/prednisone and 7 complete responses out of 19 patients (37%) treated with Vincristine/Prednisone. In 37 patients resistant to vincristine, there were 7 complete responses (19%). Vindesine was more toxic than Vincristine. Major toxicities of vindesine included paraesthesias, peripheral neuropathy and ileus. Vindesine hematological toxicity appeared greater, but such toxicity is hard to assess in patients with bone marrow disease. In this study, vindesine and vincristine had similar efficacy, but vindesine use was associated with more toxicity. C1 UNIV KANSAS,MED CTR,KANSAS CITY,KS 66103. UNIV TEXAS,HLTH SCI CTR,SW MED SCH,DALLAS,TX 75235. UNIV FLORIDA,SHANDS TEACHING HOSP,GAINESVILLE,FL 32611. EMORY UNIV,SCH MED,ATLANTA,GA 30322. UNIV S FLORIDA,TAMPA,FL 33620. UNIV OKLAHOMA,HLTH SCI CTR,OKLAHOMA CITY,OK 73190. STANFORD UNIV,MED CTR,PALO ALTO,CA 94304. YALE UNIV,SCH MED,NEW HAVEN,CT 06510. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. PEDIAT ONCOL GRP,STAT OFF,GAINESVILLE,FL. FU NCI NIH HHS [CA-20549, CA-29281, CA-30969] NR 8 TC 10 Z9 10 U1 0 U2 1 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 0167-6997 J9 INVEST NEW DRUG JI Invest. New Drugs PD AUG PY 1992 VL 10 IS 3 BP 231 EP 234 DI 10.1007/BF00877252 PG 4 WC Oncology; Pharmacology & Pharmacy SC Oncology; Pharmacology & Pharmacy GA JX010 UT WOS:A1992JX01000015 PM 1428733 ER PT J AU MAYERS, DL MCCUTCHAN, FE SANDERSBUELL, EE MERRITT, LI DILWORTH, S FOWLER, AK MARKS, CA RUIZ, NM RICHMAN, DD ROBERTS, CR BURKE, DS AF MAYERS, DL MCCUTCHAN, FE SANDERSBUELL, EE MERRITT, LI DILWORTH, S FOWLER, AK MARKS, CA RUIZ, NM RICHMAN, DD ROBERTS, CR BURKE, DS TI CHARACTERIZATION OF HIV ISOLATES ARISING AFTER PROLONGED ZIDOVUDINE THERAPY SO JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY LA English DT Article DE ZIDOVUDINE RESISTANCE; REVERSE TRANSCRIPTASE; DNA SEQUENCE; SUSCEPTIBILITY ASSAY ID HUMAN-IMMUNODEFICIENCY-VIRUS; REVERSE-TRANSCRIPTASE; REDUCED SENSITIVITY; AZT THERAPY; AIDS; MUTAGENESIS; RESISTANCE; MUTATIONS; PATIENT; DOMAIN AB Human immunodeficiency virus type 1 (HIV-1) was isolated from five patients with late-stage disease treated with zidovudine (ZDV) for more than 1 year. Peripheral blood mononuclear cells (PBMCs) were used for all virus isolations and to assay for drug resistance. The isolates exhibited a 10- to 100-fold decrease in ZDV susceptibility compared to pretreatment isolates. Multiple clones of a 618 bp segment of the HIV reverse transcriptase gene encompassing codons 60-250 were sequenced for each isolate. The association of alterations at codons Asp67 --> Asn, Lys70 --> Arg, Thr215 --> Phe or Tyr, and Lys219 --> Gln with ZDV resistance has been previously noted (ref. 5). In this study, the most frequent alteration was Thr215 --> Tyr although genotypic mixtures of Thr/Tyr and Phe/Tyr were also observed. One isolate with a Tyr215 alteration and unaltered codons at 67, 70, and 219 had high-level ZDV resistance. Alterations at codons 67, 70, and 219 did not appear to increase resistance when seen in combination with Tyr215. Virus isolates obtained from each patient by cultivation with either 0 or 4-mu-M ZDV were compared and found to have similar alterations at codons 67, 70, 215, and 219, although one instance of apparent in vitro selection for Tyr215 over Phe215 was observed. Assays using PBMCs for virus propagation will permit susceptibility testing of HIV isolates from most patients on antiretroviral drugs to investigate the clinical significance of drug resistance. C1 USN,MED RES INST,BETHESDA,MD 20814. HENRY M JACKSON FDN ADVANCEMENT MIL MED,ROCKVILLE,MD. SRA TECHNOL INC,ROCKVILLE,MD. UNIV CALIF SAN DIEGO,DEPT PATHOL & MED,LA JOLLA,CA 92093. VET AFFAIRS MED CTR,DEPT PATHOL & MED,SAN DIEGO,CA. WALTER REED ARMY MED CTR,DIV RETROVIROL,WASHINGTON,DC 20307. OI /0000-0002-5704-8094 NR 30 TC 56 Z9 56 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 1077-9450 J9 J ACQ IMMUN DEF SYND JI J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. PD AUG PY 1992 VL 5 IS 8 BP 749 EP 759 PG 11 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA JE582 UT WOS:A1992JE58200001 PM 1381438 ER PT J AU GARDNER, LI BRUNDAGE, JF MCNEIL, JG MILAZZO, MJ REDFIELD, RR ARONSON, NE CRAIG, DB DAVIS, C GATES, RH LEVIN, LI MICHAEL, RA OSTER, CN RYAN, WC BURKE, DS TRAMONT, EC AF GARDNER, LI BRUNDAGE, JF MCNEIL, JG MILAZZO, MJ REDFIELD, RR ARONSON, NE CRAIG, DB DAVIS, C GATES, RH LEVIN, LI MICHAEL, RA OSTER, CN RYAN, WC BURKE, DS TRAMONT, EC TI PREDICTORS OF HIV-1 DISEASE PROGRESSION IN EARLY-STAGE AND LATE-STAGE PATIENTS - THE UNITED-STATES-ARMY NATURAL-HISTORY COHORT SO JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY LA English DT Article DE HIV-1 DISEASE PROGRESSION; HIV-1 NATURAL HISTORY; GENDER; RACE; TEMPORAL TREND ID HUMAN-IMMUNODEFICIENCY-VIRUS; SEROPOSITIVE HOMOSEXUAL MEN; LYMPHOCYTE SUBSETS; BLOOD-TRANSFUSION; AIDS; INFECTION; SURVIVAL; AGE; ZIDOVUDINE; HEMOPHILIA AB HIV-infected individuals in both early and late stages of HIV disease were evaluated over 2 years to assess temporal trends and determinants of disease progression. The Walter Reed (WR) staging system was used to categorize patients into an early-stage cohort (WR Stages 1 and 2, N = 1183) and a late-stage cohort (WR Stage 5, N = 260) based on the initial clinical evaluation. Progression was defined as the occurrence of Stage 5 disease or beyond for the early cohort and Stage 6 disease or beyond for the late cohort. The cumulative incidence of progression was 15.7% (137 events) for the early-stage cohort, and 53.7% (85 events) for the late-stage cohort. Baseline CD4+ T lymphocyte (T4) count was the most significant marker of progression: 26% of WR Stage 1 or 2 patients with T4 lymphocytes below 500/mm3 progressed, compared with 12% with T4 lymphocytes at or above 500/mm3. In late-stage individuals, 83% with T4 lymphocytes under 200/mm3 progressed, compared with 27% with T4 lymphocytes at or above 200/mm3. Older age was associated with progression in both early- and late-stage groups. Differences in the rates of disease progression were not significant between blacks and whites or between men and women. Two-year rates of progression among the late-stage patients dropped from 78 to 47% between 1986 and 1988. This contrasted with progression rates in the early-stage cohort, which remained stable: 18% for those entering follow-up in 1986 and 17% for those entering follow-up in 1988. These data indicate a significant slowing of HIV disease progression rates and mortality rates among individuals with late-stage disease that is temporally associated with the increased availability and use of therapies. With control of T4 lymphocyte count, age, and calendar time, neither gender nor race was significantly associated with progression in either early- or late-stage patients. C1 SRA TECHNOL INC,ALEXANDRIA,VA. WALTER REED ARMY MED CTR,DIV RETROVIROL,WASHINGTON,DC 20307. WILLIAM BEAUMONT ARMY MED CTR,INFECT DIS SERV,EL PASO,TX 79920. EISENHOWER ARMY MED CTR,INFECT DIS SERV,FT GORDON,GA. BROOKE ARMY MED CTR,INFECT DIS SERV,FT SAM HOUSTON,TX 78234. FITZSIMONS ARMY MED CTR,INFECT DIS SERV,AURORA,CO 80045. MADIGAN ARMY MED CTR,INFECT DIS SERV,TACOMA,WA 98431. WALTER REED ARMY MED CTR,INFECT DIS SERV,WASHINGTON,DC 20307. RP GARDNER, LI (reprint author), WALTER REED ARMY MED CTR,DEPT EPIDEMIOL,DIV PREVENT MED,WASHINGTON,DC 20037, USA. NR 44 TC 31 Z9 32 U1 0 U2 2 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 1077-9450 J9 J ACQ IMMUN DEF SYND JI J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. PD AUG PY 1992 VL 5 IS 8 BP 782 EP 793 PG 12 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA JE582 UT WOS:A1992JE58200004 PM 1517964 ER PT J AU DUNCAN, WE SOLOMON, BL CHANG, AS WARTOFSKY, L AF DUNCAN, WE SOLOMON, BL CHANG, AS WARTOFSKY, L TI TREATMENT WITH THYROID-HORMONE - EFFECT ON SPINE BONE-MINERAL DENSITY (BMD) SO JOURNAL OF BONE AND MINERAL RESEARCH LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU BLACKWELL SCIENCE INC PI MALDEN PA 350 MAIN ST, MALDEN, MA 02148 SN 0884-0431 J9 J BONE MINER RES JI J. Bone Miner. Res. PD AUG PY 1992 VL 7 SU 1 BP S328 EP S328 PG 1 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA JL595 UT WOS:A1992JL59500938 ER PT J AU JACKSON, S TSENG, YC LAHIRI, S BURMAN, KD WARTOFSKY, L AF JACKSON, S TSENG, YC LAHIRI, S BURMAN, KD WARTOFSKY, L TI RECEPTORS FOR ENDOTHELIN IN CULTURED HUMAN THYROID-CELLS AND INHIBITION BY ENDOTHELIN OF THYROGLOBULIN SECRETION SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM LA English DT Article ID ATRIAL-NATRIURETIC-PEPTIDE; SMOOTH-MUSCLE CELLS; IMMUNOREACTIVE ENDOTHELIN; STIMULATES RELEASE; MESANGIAL CELLS; GROWTH-FACTOR; HUMAN-PLASMA; C-FOS; RAT; PITUITARY AB Specific receptors for endothelin-1 (ET), a newly described vasoconstrictor peptide isolated from endothelium, have been identified in endocrine tissues such as hypothalamus, adrenal and pituitary. ET binding or action, not previously described in thyroid, were explored in this study. ET binding in cultured human thyrocytes was assayed at 4 C, 25 C, and 37 C, for 0.5-6 h with [I-125]ET (0.1 nmol/L), and nonspecific binding estimated by coincubation with unlabeled ET (100 nmol/L). At 4 C, maximum specific binding was reached after 4 h; at 25 C and 37 C, specific binding increased in a time-dependent manner over 6 h with increased binding obtained at higher temperature. At 37 C after 2 h, 11% specific bound ET localized to surface membranes with 89% internalized. Scatchard analysis of surface membrane binding at 4 C for 4 h showed high affinity single class ET receptor (K(d) = 0.20 nmol/L) and binding capacity of 4045 sites per cell. ET binding to thyroid cells had no effect on production of cAMP or cGMP. ET (0.1 nmol/L) significantly (P < 0.001) inhibited thyroglobulin release from thyroid cells after 6 days with no effect on thymidine incorporation. Thus, we have identified specific receptors for endothelin in human thyrocytes, and an inhibitory action of the peptide on thyroglobulin release which is mediated by a noncyclic nucleotide mechanism. C1 WALTER REED ARMY MED CTR, DEPT MED, WASHINGTON, DC 20307 USA. UNIFORMED SERV UNIV HLTH SCI, BETHESDA, MD 20814 USA. WALTER REED ARMY MED CTR, DEPT CLIN INVEST, WASHINGTON, DC 20307 USA. NR 45 TC 26 Z9 26 U1 0 U2 0 PU ENDOCRINE SOC PI CHEVY CHASE PA 8401 CONNECTICUT AVE, SUITE 900, CHEVY CHASE, MD 20815-5817 USA SN 0021-972X J9 J CLIN ENDOCR METAB JI J. Clin. Endocrinol. Metab. PD AUG PY 1992 VL 75 IS 2 BP 388 EP 392 DI 10.1210/jc.75.2.388 PG 5 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA JG867 UT WOS:A1992JG86700012 PM 1322423 ER PT J AU GILILLAND, JL TSENG, YCL TROCHE, V LAHIRI, S WARTOFSKY, L AF GILILLAND, JL TSENG, YCL TROCHE, V LAHIRI, S WARTOFSKY, L TI ATRIAL-NATRIURETIC-PEPTIDE RECEPTORS IN HUMAN ENDOMETRIAL STROMAL CELLS SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM LA English DT Article ID ADENYLATE-CYCLASE ACTIVITY; HUMAN THYROID-CELLS; THYROGLOBULIN SECRETION; ADRENAL GLOMERULOSA; CYCLIC-GMP; RAT UTERUS; CGMP; INVITRO; ANP; ACCUMULATION AB Atrial natriuretic peptide (ANP) has been shown to affect water and ion transport and specific ANP binding has been identified in several secretory tissues. ANP commonly acts via stimulation of membrane-bound particulate guanylate cyclase with the production of cyclic guanosine monophosphate (cGMP). We questioned whether ANP played a role in the complex cyclic transformation of the endometrium into a secretory tissue, and whether its action was cGMP mediated. Endometrium was obtained by biopsy in regularly menstruating women and stromal cells were isolated and cultured for use in this study. ANP competitive binding assays were performed using I-125-labeled ANP (0.1 nmol/L) and increasing concentrations of unlabeled ANP (0-1000 nmol/L). Optimal binding was obtained after 3-h incubation at 4 C and binding characteristics, including dissociation constant and binding site quantity, were estimated by Scatchard analysis. Specific, high affinity (dissociation constant, 0.078 +/- 0.004 nmol/L) and low capacity (4,877 +/- 1,951 binding sites/cell) ANP binding was identified, with nonspecific binding representing less than or equal to 16% of total binding. Evaluation of ANP-stimulated cyclic nucleotide production revealed an increase in cGMP production, with a 7-fold increase at 1000 nmol/L ANP, and no effect on cAMP production. In conclusion, we have identified specific high affinity receptors for ANP in human endometrial cells, suggesting a role for ANP in endometrial cell function and/or development mediated via cGMP production. We propose that ANP may affect local salt and water metabolism, may be involved in the secretory evolution of glandular and stromal cells, and may further facilitate endometrial development via modulation of local vascular tone and endothelial permeability. C1 WALTER REED ARMY MED CTR, DEPT MED, REPROD SERV, 7D, WASHINGTON, DC 20307 USA. WALTER REED ARMY MED CTR, ENDOCRINE METAB SERV, WASHINGTON, DC 20307 USA. NR 38 TC 11 Z9 11 U1 0 U2 0 PU ENDOCRINE SOC PI CHEVY CHASE PA 8401 CONNECTICUT AVE, SUITE 900, CHEVY CHASE, MD 20815-5817 USA SN 0021-972X J9 J CLIN ENDOCR METAB JI J. Clin. Endocrinol. Metab. PD AUG PY 1992 VL 75 IS 2 BP 547 EP 551 DI 10.1210/jc.75.2.547 PG 5 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA JG867 UT WOS:A1992JG86700040 PM 1322428 ER PT J AU ORR, N ROBIN, G LOWELL, G COHEN, D AF ORR, N ROBIN, G LOWELL, G COHEN, D TI PRESENCE OF SPECIFIC IMMUNOGLOBULIN A-SECRETING CELLS IN PERIPHERAL-BLOOD AFTER NATURAL INFECTION WITH SHIGELLA-SONNEI SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID SALMONELLA-TYPHI; IMMUNE-RESPONSE; PROTECTION; VACCINE; LIPOPOLYSACCHARIDE; IMMUNIZATION; LYMPHOCYTES; FLEXNERI AB The appearance of antigen-specific immunoglobulin A (IgA) antibody-secreting cells (ASCs) following natural infection with Shigella sonnei during a common-source outbreak caused by this organism was evaluated in a modified enzyme-linked immunosorbent assay (ELISPOT). A mean IgA ASC value of 2,131.6/10(6) cells against homologous S. sonnei lipopolysaccharide (LPS) was detected in blood samples obtained from patients with bacteriologically proven S. sonnei shigellosis 5 and 10 days after the onset of disease. In the same blood samples, the level of ASC measured against heterologous antigen (Shigella flexneri serotype 2a LPS) was significantly lower than that of the homologous antigen (mean value, 33.12/10(6) cells). Furthermore, the mean number of activated B cells that secreted anti-S. sonnei LPS antibodies was significantly higher among patients with S. sonnei shigellosis than it was among patients with non-Shigella diarrhea (2.5/10(6) cells; standard error, 1.0) and healthy subjects (5.1/10(6) cells; standard error, 2.3) (P < 0.05). The anti-LPS IgA ASC activity was easily detected within 5 days of the onset of disease, a point at which the levels of anti-S. sonnei LPS IgG and even IgA antibodies were hardly detectable in serum. C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. RP ORR, N (reprint author), ISRAEL DEF FORCES,MED CORPS,MIL POST 02149,JERUSALEM,ISRAEL. NR 19 TC 16 Z9 16 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD AUG PY 1992 VL 30 IS 8 BP 2165 EP 2168 PG 4 WC Microbiology SC Microbiology GA JD594 UT WOS:A1992JD59400050 PM 1500527 ER PT J AU KARLE, JM KARLE, IL LEADER, H BREUER, E NEWMAN, AH GORDON, RK CHIANG, PK AF KARLE, JM KARLE, IL LEADER, H BREUER, E NEWMAN, AH GORDON, RK CHIANG, PK TI RELATIONSHIP OF THE CRYSTAL-STRUCTURE OF GAMMA-N,N-DIMETHYLAMINOPROPYL 2,2-DIPHENYLPROPIONATE HYDROCHLORIDE TO ANTIMUSCARINIC ACTIVITY SO JOURNAL OF CRYSTALLOGRAPHIC AND SPECTROSCOPIC RESEARCH LA English DT Article ID RECEPTORS; ANALOGS; BINDING AB The title compound was synthesized, characterized by H-1 nmr, and crystallized for x-ray crystallography. The antimuscarinic potency of the title compound was about equipotent to aprophen or atropine in inhibiting acetylcholine-induced contraction of guinea pig ileum (K(B) = 4.5 nM) and in inhibiting carbachol-stimulated release of alpha-amylase from rat pancreatic acinar cells (K(i) = 1.4 nM), and in inhibiting the binding of [N-methyl-H-3]scopolamine to cerebral cortex (K(i) = 6.6 nM). In the crystal, the O-C-C-C-N+ segment adopted a gauche-gauche configuration resulting in an N+ ... O (carbonyl) distance of 5.001(9) angstrom, a distance comparable to that in aprophen. The ether oxygen atom is buried rendering it inaccessible for interaction with the muscarinic receptor. The carbonyl oxygen atom is exposed to the surface of the molecule and is readily accessible for intermolecular interactions. The similarity in biological activities of the title compound and aprophen is congruous with their similar N+ ... O (carbonyl) distances. C1 USN,RES LAB,STRUCT MATTER LAB,WASHINGTON,DC 20375. WALTER REED ARMY MED CTR,DIV BIOCHEM,APPL BIOCHEM BRANCH,WASHINGTON,DC 20307. RP KARLE, JM (reprint author), WALTER REED ARMY MED CTR,DEPT PHARMACOL,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307, USA. RI Breuer, Eli/E-8382-2011 NR 15 TC 0 Z9 0 U1 0 U2 1 PU PLENUM PUBL CORP PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 SN 0277-8068 J9 J CRYST SPECTROSC PD AUG PY 1992 VL 22 IS 4 BP 485 EP 491 DI 10.1007/BF01195411 PG 7 WC Crystallography; Spectroscopy SC Crystallography; Spectroscopy GA JR151 UT WOS:A1992JR15100015 ER PT J AU SMITH, KJ SKELTON, HG MORGAN, AM BARRETT, TL LUPTON, GP AF SMITH, KJ SKELTON, HG MORGAN, AM BARRETT, TL LUPTON, GP TI SPINDLE CELL NEOPLASMS COEXPRESSING CYTOKERATIN AND VIMENTIN (METAPLASTIC SQUAMOUS-CELL CARCINOMA) SO JOURNAL OF CUTANEOUS PATHOLOGY LA English DT Article ID ATYPICAL FIBROXANTHOMA; INTERMEDIATE FILAMENTS; SKIN; TUMORS; SARCOMA; HISTOGENESIS; PROTEINS; LESIONS; KERATIN; GLAND AB Spindle cell squamous carcinoma (SCSC) and atypical fibroxanthoma (AFX) are both spindle cell neoplasms (SCN) that usually arise in areas of solar or ionizing radiation of elderly patients. Both lesions have a similar biologic behavior. In addition, the morphologic and ultrastructural similarities found in AFX and the spindle cell component of SCSC, have led some investigators to conclude that these tumors have a similar cell of origin. We studied 15 SCNs with no evidence of epithelial origin and no morphologic epithelial component, that showed immunohistochemical and ultrastructural evidence that would support metaplastic changes of a squamous cell carcinoma to a neoplasm with mesenchymal characteristics. C1 ARMED FORCES INST PATHOL,DEPT DERMATOPATHOL,WASHINGTON,DC 20306. WALTER REED ARMY MED CTR,DEPT DERMATOPATHOL,WASHINGTON,DC 20307. SCRIPPS CLIN & RES FDN,DEPT DERMATOPATHOL,LA JOLLA,CA 92037. NR 27 TC 29 Z9 29 U1 0 U2 0 PU MUNKSGAARD INT PUBL LTD PI COPENHAGEN PA 35 NORRE SOGADE, PO BOX 2148, DK-1016 COPENHAGEN, DENMARK SN 0303-6987 J9 J CUTAN PATHOL JI J. Cutan. Pathol. PD AUG PY 1992 VL 19 IS 4 BP 286 EP 293 DI 10.1111/j.1600-0560.1992.tb01364.x PG 8 WC Dermatology; Pathology SC Dermatology; Pathology GA JJ765 UT WOS:A1992JJ76500004 PM 1385501 ER PT J AU PHILLIPS, JL WELLER, RN KULILD, JC AF PHILLIPS, JL WELLER, RN KULILD, JC TI THE MENTAL FORAMEN .3. SIZE AND POSITION ON PANORAMIC RADIOGRAPHS SO JOURNAL OF ENDODONTICS LA English DT Article AB Panoramic radiographs were made of 75 dry, adult human mandibles. The size and position of the mental foramen in relation to the second premolar was determined. The mental foramen on panographic radiographs was slightly larger than reported on periapical radiographs. The average position of the foramen was mesial and below the radiographic apex of the tooth. Panoramic radiography may account for a distal shift of the foramen and a 23% increase in size of the mandibles examined. C1 USA,DENT ACT,POSTGRAD PROGRAM,ENDODONT RESIDENCY PROGRAM,FT GORDON,GA 30905. NR 9 TC 22 Z9 22 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0099-2399 J9 J ENDODONT JI J. Endod. PD AUG PY 1992 VL 18 IS 8 BP 383 EP 386 DI 10.1016/S0099-2399(06)81224-0 PG 4 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA JG874 UT WOS:A1992JG87400006 PM 1431694 ER PT J AU WONG, M SHELLEY, JJ BODEY, T HALL, R AF WONG, M SHELLEY, JJ BODEY, T HALL, R TI DELAYED ROOT-CANAL THERAPY - AN ANALYSIS OF TREATMENT OVER TIME SO JOURNAL OF ENDODONTICS LA English DT Article ID NECROTIC PULPS; FLARE-UPS; ENDODONTICS; PAIN AB A retrospective study of 898 teeth receiving root canal therapy was performed to document the sequelae of delayed completion of root canal treatment. Teeth were categorized into a prompt treatment group and a delayed treatment group. Comparisons of prompt and delayed treatment groups were made with regard to preoperative pain, interappointment emergencies, postobturation pain, and final treatment. Findings from this study show that a palliative endodontic procedure is an extremely effective treatment. However, 56% of teeth with incomplete root canal therapy eventually were extracted compared with 2 to 3% for the root canal filling treatment groups. By emphasizing the potential loss of the tooth rather than the potential of interappointment emergencies, the clinician may be more effective in achieving compliance among patients receiving delayed treatment. C1 TEXCOM,FT HOOD,TX. USA,DENT ACT,FT HUACHUCA,AZ. RP WONG, M (reprint author), USA,DENT ACT,FT HOOD,TX, USA. NR 15 TC 5 Z9 5 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0099-2399 J9 J ENDODONT JI J. Endod. PD AUG PY 1992 VL 18 IS 8 BP 387 EP 390 DI 10.1016/S0099-2399(06)81225-2 PG 4 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA JG874 UT WOS:A1992JG87400007 PM 1279093 ER PT J AU ANDERSON, R KING, AD INNIS, BL AF ANDERSON, R KING, AD INNIS, BL TI CORRELATION OF E-PROTEIN BINDING WITH CELL SUSCEPTIBILITY TO DENGUE-4 VIRUS-INFECTION SO JOURNAL OF GENERAL VIROLOGY LA English DT Note ID BORNE ENCEPHALITIS-VIRUS; WEST NILE; STRUCTURAL PROTEINS; MOSQUITO CELLS; SINDBIS VIRUS; FLAVIVIRUS; PH; GLYCOPROTEIN; ENTRY AB Supernatant culture fluids from dengue virus type 4 (DEN-4)-infected cultures of monkey kidney Vero cells and Aedes albopictus C6/36 cells contained the virion structural proteins; secreted NS1 was found only in supernatants from infected Vero cells. Using supernatant culture fluids from [S-35]methionine-labelled, virus-infected Vero and C6/36 cells, binding of radiolabelled viral proteins was examined with various cell lines varying in susceptibility to DEN-4 infection. Binding of viral E protein was observed with the highly infectible Vero and LLC-MK2 cell lines, whereas a very small degree of binding was seen with four other cell lines (mouse fibroblast L929, bovine kidney MDBK, human hepatoma Hep G2 and primary human endothelial cells) which are less susceptible to DEN-4 infection. The results suggest that cell susceptibility to DEN-4 may be determined largely at the stage of virus binding, i.e. by the presence of a cell receptor capable of binding viral E protein. C1 ARMED FORCES RES INST MED SCI,DEPT VIROL,BANGKOK 10400,THAILAND. RP ANDERSON, R (reprint author), UNIV CALGARY,DEPT MICROBIOL & INFECT DIS,CALGARY T2N 1N4,ALBERTA,CANADA. NR 19 TC 45 Z9 46 U1 0 U2 2 PU SOC GENERAL MICROBIOLOGY PI READING PA HARVEST HOUSE 62 LONDON ROAD, READING, BERKS, ENGLAND RG1 5AS SN 0022-1317 J9 J GEN VIROL JI J. Gen. Virol. PD AUG PY 1992 VL 73 BP 2155 EP 2159 DI 10.1099/0022-1317-73-8-2155 PN 8 PG 5 WC Biotechnology & Applied Microbiology; Virology SC Biotechnology & Applied Microbiology; Virology GA JG774 UT WOS:A1992JG77400036 PM 1645154 ER PT J AU SEDEGAH, M SIM, BKL MASON, C NUTMAN, T MALIK, A ROBERTS, C JOHNSON, A OCHOLA, J KOECH, D WERE, B HOFFMAN, SL AF SEDEGAH, M SIM, BKL MASON, C NUTMAN, T MALIK, A ROBERTS, C JOHNSON, A OCHOLA, J KOECH, D WERE, B HOFFMAN, SL TI NATURALLY ACQUIRED CD8+ CYTOTOXIC LYMPHOCYTES-T AGAINST THE PLASMODIUM-FALCIPARUM CIRCUMSPOROZOITE PROTEIN SO JOURNAL OF IMMUNOLOGY LA English DT Article ID MALARIA SPOROZOITES; CS PROTEIN; CELLS; EPITOPE; ANTIBODIES; PROTECTION; RECOGNIZE; GAMMA; CD4+ AB In rodent malaria model systems, protective immunity induced by immunization with irradiated sporozoites is eliminated by in vivo depletion of CD8+ T cells, and adoptive transfer of CTL clones against the circumsporozoite protein protects against malaria. We recently demonstrated that volunteers immunized with irradiated Plasmodium falciparum sporozoites produce CTL against peptide 368-390 of the P.falciparum circumsporozoite protein. To determine whether natural exposure to malaria induced similar CTL, we studied 11 adult, male, life-long residents of a highly malarious area of Kenya, who were selected because their lymphocytes had been shown to proliferate after stimulation with peptides 361-380, 371-390, or 368-390 and because nine had been resistant to malaria in previous studies. In four of the 11 individuals there was peptide-specific, genetically restricted, CTL activity. In all four individuals, this activity was unaffected by depletion of CD4+ T cells. In three volunteers the activity was eliminated or reduced by depletion of CD8+ T cells; in the fourth volunteer the CD8+ T cell depletion was uninterpretable. This first demonstration of CD8+ T cell, genetically restricted, Ag-specific CTL against a malaria protein among individuals exposed to endemic malaria provides a foundation for studying the relationship between circulating CTL and resistance to malaria infection. C1 USN,MED RES INST,DEPT DEF,MALARIA VACCINE PROGRAM,BETHESDA,MD 20889. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. PAN AMER HLTH ORG,WASHINGTON,DC 20037. USA,MED RES UNIT KENYA,NEW YORK,NY 09675. GEORGETOWN UNIV,DEPT PEDIAT,WASHINGTON,DC 20007. KENYA GOVT MED RES CTR,NAIROBI,KENYA. NIH,PARASIT DIS LAB,BETHESDA,MD 20892. OI MASON, CARL/0000-0002-3676-2811 NR 23 TC 61 Z9 61 U1 0 U2 0 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD AUG 1 PY 1992 VL 149 IS 3 BP 966 EP 971 PG 6 WC Immunology SC Immunology GA JF474 UT WOS:A1992JF47400030 PM 1634778 ER PT J AU GUNZENHAUSER, JD BRUNDAGE, JF MCNEIL, JG MILLER, RN AF GUNZENHAUSER, JD BRUNDAGE, JF MCNEIL, JG MILLER, RN TI BROAD AND PERSISTENT EFFECTS OF BENZATHINE PENICILLIN-G IN THE PREVENTION OF FEBRILE, ACUTE RESPIRATORY-DISEASE SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID CHLAMYDIA-PNEUMONIAE; MILITARY TRAINEES; STRAIN TWAR; INFECTIONS; PHARYNGITIS; MYCOPLASMA; EPIDEMICS; VIRUSES; ADULTS AB After an outbreak of acute rheumatic fever at a US Army training installation, a benzathine penicillin G prophylaxis program was instituted. Surveillance data were analyzed to measure rates of febrile, acute respiratory disease (ARD) among trainees before and after prophylaxis was begun. Annual admissions for ARD decreased from 1927 to 690 (-64.2%) after benzathine penicillin G prophylaxis was begun. Admissions with throat cultures positive for Streptococcus pyogenes fell from 595 to 63 (-89.4%), a reduction that accounted only for a minority (43%) of the total 1237 "prevented" admissions. Temporal changes in disease rates at other installations where drug was not administered were also analyzed. Only a small decrease in the number of annual ARD admissions (-6.3%) was observed at other training installations. These findings support a hypothesis that benzathine penicillin G has a broad effect in the prevention of ARD that extends beyond the simple elimination of group A streptococcal infection. C1 WALTER REED ARMY MED CTR,DIV PREVENT MED,WASHINGTON,DC 20307. NR 26 TC 21 Z9 21 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD AUG PY 1992 VL 166 IS 2 BP 365 EP 373 PG 9 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA JE578 UT WOS:A1992JE57800020 PM 1634808 ER PT J AU DHAWAN, S TORO, LA JONES, BE MELTZER, MS AF DHAWAN, S TORO, LA JONES, BE MELTZER, MS TI INTERACTIONS BETWEEN HIV-INFECTED MONOCYTES AND THE EXTRACELLULAR-MATRIX - HIV-INFECTED MONOCYTES SECRETE NEUTRAL METALLOPROTEASES THAT DEGRADE BASEMENT-MEMBRANE PROTEIN MATRICES SO JOURNAL OF LEUKOCYTE BIOLOGY LA English DT Note DE BASEMENT MEMBRANE; EXTRACELLULAR MATRIX; METALLOPROTEASE; HIV-1 ID HUMAN MONONUCLEAR PHAGOCYTES; CELL TROPISM; AIDS VIRUS; MACROPHAGES; EXPRESSION; IDENTIFICATION; TISSUE AB The frequency of human immunodeficiency virus (HIV)-infected monocytes that spread on a model basement membrane was about twofold greater than that of an equal number of uninfected control cells through the initial 12 to 18 h of culture. By 24 h, virtually all HIV-infected and uninfected control cells spread on the basement membrane gel. The frequency of spread cells in the uninfected control population was < 10% of total cells by 12 days. In contrast, 30 to 40% of HIV-infected monocytes remained spread through this time interval and formed a dense interdigitated network of cell processes on and into the gel matrix. Invasion of the basement membrane matrix by HIV-infected monocytes suggested increased secretion of proteases able to digest the gel. Indeed, levels of neutral protease activity in culture fluids from HIV-infected monocytes were significantly higher than those from equal numbers of uninfected control cells. High levels of protease activity in culture fluids of HIV-infected monocytes required productive virus infection and were not observed with cells exposed to T cell-tropic HIV isolates. The predominant protease activity in these cultures was a 92-kd neutral metallogelatinase. HIV-induced changes in monocyte metalloprotease activity may be important for extravasation of infected cells to tissue or for the development of AIDS-associated neuropathology, carcinogenesis, and opportunistic infection. C1 WALTER REED ARMY MED CTR,DEPT CELLULAR IMMUNOL,DIV COMMUNICABLE DIS & IMMUNOL,WASHINGTON,DC 20307. NEI,BETHESDA,MD 20892. NR 23 TC 26 Z9 26 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0741-5400 J9 J LEUKOCYTE BIOL JI J. Leukoc. Biol. PD AUG PY 1992 VL 52 IS 2 BP 244 EP 248 PG 5 WC Cell Biology; Hematology; Immunology SC Cell Biology; Hematology; Immunology GA JQ370 UT WOS:A1992JQ37000017 PM 1506780 ER PT J AU MILLS, JN ELLIS, BA MCKEE, KT MAIZTEGUI, JI CHILDS, JE AF MILLS, JN ELLIS, BA MCKEE, KT MAIZTEGUI, JI CHILDS, JE TI REPRODUCTIVE CHARACTERISTICS OF RODENT ASSEMBLAGES IN CULTIVATED REGIONS OF CENTRAL ARGENTINA SO JOURNAL OF MAMMALOGY LA English DT Article DE RODENTIA; REPRODUCTION; ARGENTINA ID HABITAT; POPULATIONS; MOUSE AB Small mammals were trapped for 2 years at 16 localities on the central-Argentine pampa. Six species (Akodon azarae, Calomys musculinus, C. laucha, Bolomys obscurus, Oligoryzomys flavescens and Mus musculus) accounted for >95% of captures. The major breeding season, as assessed by pregnancies, was September or October through April or May. Mild weather in late autumn and winter of the second season resulted in a relatively longer breeding season during the 2nd year of the study. Females of all six species comprised significantly <50% of captures throughout the non-breeding season, but >50% of captures during the height of the breeding season. For most species, there was a negative correlation between embryo size and embryos per pregnancy; females with large embryos were poorly represented. C. musculinus had the longest breeding season; C. musculinus and Mus had the highest number of embryos per pregnancy; the two species of Calomys and Oligoryzomys had the highest percentages of pregnant females during the breeding season. The predominance of animals of smaller mass classes during the winter is thought to represent seasonal weight loss rather than juvenile recruitment. C1 USA,MED RES INST INFECT DIS,DIV MED,FREDERICK,MD 21701. INST NACL ESTUDIOS SOBRE VIROSIS HEMORRAGICAS,RA-2700 PERGAMINO,ARGENTINA. RP MILLS, JN (reprint author), JOHNS HOPKINS UNIV,DEPT IMMUNOL & INFECT DIS,BALTIMORE,MD 21205, USA. RI Childs, James/B-4002-2012 NR 34 TC 45 Z9 51 U1 0 U2 2 PU AMER SOC MAMMALOGISTS PI PROVO PA BRIGHAM YOUNG UNIV, DEPT OF ZOOLOGY, PROVO, UT 84602 SN 0022-2372 J9 J MAMMAL JI J. Mammal. PD AUG PY 1992 VL 73 IS 3 BP 515 EP 526 DI 10.2307/1382017 PG 12 WC Zoology SC Zoology GA JK336 UT WOS:A1992JK33600006 ER PT J AU GROEN, J DALRYMPLE, J FISHERHOCH, S JORDANS, JGM CLEMENT, JP OSTERHAUS, ADME AF GROEN, J DALRYMPLE, J FISHERHOCH, S JORDANS, JGM CLEMENT, JP OSTERHAUS, ADME TI SERUM ANTIBODIES TO STRUCTURAL PROTEINS OF HANTAVIRUS ARISE AT DIFFERENT TIMES AFTER INFECTION SO JOURNAL OF MEDICAL VIROLOGY LA English DT Article DE PUUMALA VIRUS; NUCLEOPROTEIN; GLYCOPROTEIN; IGM AND IGG IN HFRS; MONOCLONAL ANTIBODIES ID LINKED IMMUNOSORBENT ASSAYS; HEMORRHAGIC-FEVER; RENAL SYNDROME; HEMAGGLUTINATION INHIBITION; ENVELOPE GLYCOPROTEIN; MONOCLONAL-ANTIBODIES; VIRUS; IMMUNOFLUORESCENCE; SEROTYPES; HANTAAN AB An enzyme-linked immunosorbent assay (ELISA) was developed for the quantification of serum antibodies against group-specific epitopes of the glycoproteins (G1, G2) and nucleoprotein (NP) of the genus Hantavirus. This assay was used to study the kinetics of the development of serum antibodies after natural infection with Puumala-like virus in humans. To this end a panel of 34 serum samples collected from individuals at different times after natural infection was tested by the ELISA. The samples were also tested for specific IgM and IgG levels against Puumala-like virus, which provided confirmatory data about the presumed timing of infection. It was shown that serum antibodies against the G1 epitope were present in the acute and early convalescent period just before antibodies to the NP epitope could be demonstrated. In contrast, antibodies to two G2 epitopes were present not earlier than in the convalescent and late convalescent period. Since all these categories of antibodies seem to persist for long periods, antibodies against the G1 epitope and the NP epitope may be of specific diagnostic value. Furthermore, levels of G1-specific antibodies and antibodies to either NP or G2 may allow estimation of the time elapsed following initial infection. C1 NATL INST PUBL HLTH & ENVIRONM PROTECT,IMMUNOL LAB,POB 1,3720 BA BILTHOVEN,NETHERLANDS. MED SPECTRUM TWENTE,DEPT INTERNAL MED,ENSCHEDE,NETHERLANDS. USA,MED RES INST INFECT DIS,DEPT VIRAL BIOL,FREDERICK,MD 21701. MIL HOSP BRUSSELS,B-1120 BRUSSELS,BELGIUM. CTR DIS CONTROL,PUBL HLTH SERV,DEPT HLTH & HUMAN SERV,ATLANTA,GA 30333. NR 23 TC 31 Z9 33 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0146-6615 J9 J MED VIROL JI J. Med. Virol. PD AUG PY 1992 VL 37 IS 4 BP 283 EP 287 DI 10.1002/jmv.1890370409 PG 5 WC Virology SC Virology GA JG922 UT WOS:A1992JG92200008 PM 1357082 ER PT J AU FITZPATRICK, DT SHANNON, S AF FITZPATRICK, DT SHANNON, S TI HEALTH-RISK BEHAVIORS OF ARMY AIRCREW SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE LA English DT Article AB Data from the US Army Health Risk Appraisal Program were used to compare health and fitness levels in flight and nonflight personnel. Survey data collected from an aviation brigade, consisting of 428 aircrew and 899 support personnel, were compared with US Army summary statistics. Flight personnel scored better on evaluation of hypertension, stress, weight standards, and seatbelt use. However, the prevalence of smokeless tobacco use, heavy alcohol consumption, and driving after drinking or riding with someone who consumed alcohol was significantly higher in flight personnel. This study suggests that although Army aircrew have better lifestyle habits overall, high-risk behaviors have been identified that warrant further evaluation. C1 CORPS FLIGHT SURGEONS OFF,FT HOOD,TX. USA,AEROMED RES LAB,FT RUCKER,AL. RP FITZPATRICK, DT (reprint author), USA,SAFETY CTR SURGEON,FT RUCKER,AL 36362, USA. NR 4 TC 6 Z9 6 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 1076-2752 J9 J OCCUP ENVIRON MED JI J. Occup. Environ. Med. PD AUG PY 1992 VL 34 IS 8 BP 810 EP 814 DI 10.1097/00043764-199208000-00016 PG 5 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA JJ219 UT WOS:A1992JJ21900012 PM 1506939 ER PT J AU QUILLEN, WS AF QUILLEN, WS TI THE GLOBAL TOUCH OF PHYSICAL THERAPY SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY LA English DT Editorial Material RP QUILLEN, WS (reprint author), USA,BAYLOR UNIV GRAD PROGRAM PHYS THERAPY,FT SAM HOUSTON,TX 78234, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0190-6011 J9 J ORTHOP SPORT PHYS JI J. Orthop. Sports Phys. Ther. PD AUG PY 1992 VL 16 IS 2 BP 57 EP 57 PG 1 WC Orthopedics; Rehabilitation; Sport Sciences SC Orthopedics; Rehabilitation; Sport Sciences GA JJ816 UT WOS:A1992JJ81600001 ER PT J AU MCCABE, RT NEWMAN, AH SKOLNICK, P AF MCCABE, RT NEWMAN, AH SKOLNICK, P TI AHN-683 - A FLUORESCENT LIGAND FOR PERIPHERAL-TYPE BENZODIAZEPINE RECEPTORS SO JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS LA English DT Article ID DOPAMINE-RECEPTORS; PARTIAL-PURIFICATION; BINDING; VISUALIZATION; PHARMACOLOGY; SELECTIVITY; AFFINITY; SITE; D1 AB AHN 683 [1-(2-fluoro-5-N[1,3-dihydrol-1,1-bis(4-hydroxyphenyl)-3-oxo-5-isobenzofurancarboxamide]-phenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinoline carboxamide] is a fluorescein-derived ligand at peripheral-type benzodiazepine receptors structurally related to the isoquinoline carboxamide, PK 14105. The binding of AHN 683 to rat renal membranes measured by fluorescence techniques was saturable with a maximum number of binding sites of 2.3 +/- 0.3 pmol/mg of protein. The K(D) (40.4 +/-2.2 nM) estimated by fluorescence was in good agreement with the K(i) (77.4 +/- 13.5 nM) obtained in competition studies with [H-3] Ro 5-4864. AHN 683 exhibited rapid and reversible binding which was significantly reduced by the histidine modifying reagent, diethylpyrocarbonate. The potencies of a pair of isoquinoline carboxamide enantiomers as well as other structurally diverse peripheral-type benzodiazepine receptor ligands estimated by inhibition of AHN 683 binding were in good agreement with values obtained using radioligand binding techniques. AHN 683 binding was unaffected by compounds that do not recognize peripheral-type benzodiazepine receptors. Moreover, a significant increase in the maximum number of binding sites of AHN 683 to rat renal membranes after chronic furosemide treatment (29.2%, P < .02) was comparable to the increase measured using [H-3]PK 11195 (35.6%, P < .001). These findings demonstrate the feasibility of using fluorescent ligand binding techniques to quantitatively characterize peripheral-type benzodiazepine receptors. C1 NIDDKD,NEUROSCI LAB,BETHESDA,MD. WALTER REED ARMY MED CTR,DEPT APPL BIOCHEM,WASHINGTON,DC 20307. NR 18 TC 5 Z9 5 U1 0 U2 1 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-3565 J9 J PHARMACOL EXP THER JI J. Pharmacol. Exp. Ther. PD AUG PY 1992 VL 262 IS 2 BP 734 EP 740 PG 7 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA JH661 UT WOS:A1992JH66100039 PM 1323661 ER PT J AU CARMELIET, E AF CARMELIET, E TI VOLTAGE-DEPENDENT AND TIME-DEPENDENT BLOCK OF THE DELAYED K+ CURRENT IN CARDIAC MYOCYTES BY DOFETILIDE SO JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS LA English DT Article ID III ANTIARRHYTHMIC AGENTS; PIG VENTRICULAR MYOCYTES; GUINEA-PIG; POTASSIUM CHANNELS; RABBIT HEART; CELLS; QUINIDINE; UK-68,798; POTENT; DRUG AB The delayed K+ current (i(K)) and its change by dofetilide was studied in single myocytes from the guinea pig and rabbit heart using the two-electrode voltage clamp technique. In rabbit myocytes, i(K) consisted of only one component (K(r)), which developed for moderate depolarizations and with a fast time course. In guinea pig myocytes, activation consisted of a rapid and a slow component, and the latter (K(s)) only became manifest for depolarizations positive to 0 mV. K(s) was resistant to block by dofetilide. K(r), however, was very sensitive: K(d) 3.9 x 10(-9) M, Hill coefficient 2.0 (n = 5). The effect was voltage-dependent block increasing at depolarized levels. Block development was time dependent and occurred in two phases: a first fast and voltage-dependent phase was followed by a second much slower phase (time constant of 4.4 +/- 0.48 sec (n = 11). Recovery from block was slower as the membrane potential became more negative. This resulted in the absence of a steady-state frequency-dependent effect at negative membrane potentials. It is concluded that dofetilide is an efficient blocker of the fast component of i(K) The block, as well as recovery, are voltage and time dependent. Block is greater at more depolarized levels, recovery is slower at more hyperpolarized levels. RP CARMELIET, E (reprint author), USA, SCH MED, PHYSIOL LAB, HERESTR 49, FT RUCKER, AL 36360 USA. NR 15 TC 305 Z9 306 U1 0 U2 5 PU AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3995 USA SN 0022-3565 EI 1521-0103 J9 J PHARMACOL EXP THER JI J. Pharmacol. Exp. Ther. PD AUG PY 1992 VL 262 IS 2 BP 809 EP 817 PG 9 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA JH661 UT WOS:A1992JH66100048 PM 1501123 ER PT J AU LUKEY, BJ WOODARD, CL CLARK, CR MCCLUSKEY, MP AF LUKEY, BJ WOODARD, CL CLARK, CR MCCLUSKEY, MP TI HI-6 PHARMACOKINETICS IN RABBITS AFTER INTRAVENOUS AND INTRAMUSCULAR ADMINISTRATION SO JOURNAL OF PHARMACY AND PHARMACOLOGY LA English DT Note ID REACTIVATION; OXIME AB The pharmacokinetics of HI-6 ((4-carboxamidopyridinium (1) methyl)-(2'-hydroxyiminomethyl-pyridinium (1') methyl) ether dichloride) have been studied in rabbits receiving an intramuscular (50-mu-g kg-1) or intravenous (12.5-mu-g kg-1) dose. The plasma concentration-time profile for the intramuscular dose (n=8) fits a one-compartment open model with first-order absorption and elimination. The absorption half-life was 2 min and maximum concentration (51-mu-g mL-1) was reached in 9 min. The pharmacokinetics for the intravenous dose (n=8) was described by a two-compartment open model with first-order distribution and elimination. The apparent volume of distribution was 0.1 L kg-1. Half-lives of distribution and elimination were 5 and 38 min, respectively. The results indicate HI-6 is rapidly absorbed, distributed and eliminated in rabbits receiving an intramuscular dose. RP LUKEY, BJ (reprint author), USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010, USA. NR 12 TC 3 Z9 3 U1 0 U2 1 PU ROYAL PHARMACEUTICAL SOC GREAT BRITAIN PI LONDON PA 1 LAMBETH HIGH ST, LONDON, ENGLAND SE1 7JN SN 0022-3573 J9 J PHARM PHARMACOL JI J. Pharm. Pharmacol. PD AUG PY 1992 VL 44 IS 8 BP 690 EP 692 PG 3 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA JK438 UT WOS:A1992JK43800016 PM 1359099 ER PT J AU BLOODWORTH, KE AF BLOODWORTH, KE TI PREVENTING DISTORTION OF REMOVABLE PARTIAL DENTURE FRAMEWORKS DURING DEFLASKING PROCESS SO JOURNAL OF PROSTHETIC DENTISTRY LA English DT Note C1 USA,DENT ACT,FT ORD,CA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0022-3913 J9 J PROSTHET DENT JI J. Prosthet. Dent. PD AUG PY 1992 VL 68 IS 2 BP 386 EP 386 DI 10.1016/0022-3913(92)90353-C PG 1 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA JF662 UT WOS:A1992JF66200039 PM 1501196 ER PT J AU BELOHOUBEK, E DELINGER, E KALOKITIS, D FATHY, A PAGLIONE, R PENDRIK, V BROWN, J PIQUE, A WU, XD GREEN, SM MATHEWS, S EDWARDS, R MATHUR, M VENKATESAN, T AF BELOHOUBEK, E DELINGER, E KALOKITIS, D FATHY, A PAGLIONE, R PENDRIK, V BROWN, J PIQUE, A WU, XD GREEN, SM MATHEWS, S EDWARDS, R MATHUR, M VENKATESAN, T TI ADVANCED HIGH-TEMPERATURE SUPERCONDUCTING COMPONENTS FOR MICROWAVE SYSTEMS SO JOURNAL OF SUPERCONDUCTIVITY LA English DT Article DE HIGH-TEMPERATURE SUPERCONDUCTIVITY; MULTIPLEXER; NARROW-BAND FILTER; CIRCULATOR; HIGH-Q SPIRAL RESONATOR AB The application of high-temperature superconducting thin films to microwave systems is expected to lead to major volume and weight savings as well as improved performance. To take full advantage of the properties that the new materials have to offer and justify the additional cooling equipment that accompanies the introduction of superconductivity, many HTS components will have to be integrated. In this paper some of the key microwave circuits that show great promise in this respect, such as multiplexers, circulators, and very narrowband filters, will be discussed and experimental results presented. C1 NEOCERA INC,COLL PK,MD 20742. LOS ALAMOS NATL LAB,ERDC,LOS ALAMOS,NM 87545. RP BELOHOUBEK, E (reprint author), DAVID SARNOFF RES CTR,PRINCETON,NJ 08543, USA. RI Venkatesan, Thirumalai/E-1667-2013 NR 3 TC 7 Z9 7 U1 0 U2 3 PU PLENUM PUBL CORP PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 SN 0896-1107 J9 J SUPERCOND JI J. Supercond. PD AUG PY 1992 VL 5 IS 4 BP 423 EP 429 DI 10.1007/BF00618143 PG 7 WC Physics, Applied; Physics, Condensed Matter SC Physics GA JW931 UT WOS:A1992JW93100014 ER PT J AU NOBLE, JM BASS, HE RASPET, R AF NOBLE, JM BASS, HE RASPET, R TI THE EFFECT OF LARGE-SCALE ATMOSPHERIC INHOMOGENEITIES ON ACOUSTIC PROPAGATION SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Article ID TURBULENCE; SOUND AB A large-scale wind-driven turbulence model is put forth to account for long-term (1-5 min) phase variations observed in outdoor sound Propagation experiments. The long-term variations experimentally observed cannot be explained by small-scale turbulence. Fourier analysis of phase variations show outer scales of 200 m and greater, which correspond to turbulence in the energy-containing subrange. This size suggests organized atmospheric structures that may be as large as the planetary boundary layer. These structures may be elongated longitudinal vortex pairs roughly aligned with the mean wind. Because the size of the vortex pair is large compared to the scale of the experiment, the effect of the vortex pair on the acoustic field can be modeled as a time-dependent sound-speed profile. The roll vortices provide results with the same trends and variations in phase observed experimentally, but other structures present in the atmosphere might yield similar agreement with data. C1 UNIV MISSISSIPPI,DEPT PHYS & ASTRON,PHYS ACOUST RES GRP,UNIVERSITY,MS 38677. RP NOBLE, JM (reprint author), USA,ATMOSPHER SCI LAB,WHITE SANDS MISSILE RANGE,NM 88002, USA. NR 18 TC 9 Z9 9 U1 0 U2 1 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0001-4966 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD AUG PY 1992 VL 92 IS 2 BP 1040 EP 1046 DI 10.1121/1.404033 PN 1 PG 7 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA JG992 UT WOS:A1992JG99200044 ER PT J AU SAMLASKA, CP SANDBERG, GD MAGGIO, KL SAKAS, EL AF SAMLASKA, CP SANDBERG, GD MAGGIO, KL SAKAS, EL TI GENERALIZED PERFORATING GRANULOMA-ANNULARE SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Article AB Generalized perforating granuloma annulare is characterized by 1 to 4 mm umbilicated papules on the extremities, and is most commonly seen in children and young adults. Transepithelial elimination of mucinous, degenerating collagen fibers and surrounding palisading lymphohistiocytic granulomas are important histologic features. Perforating sarcoidosis and perforating granuloma annulare may be difficult to differentiate because of a similar clinical appearance and the presence of sarcoidal granulomas in biopsy specimens. A particularly high incidence of perforating granuloma annulare has been reported in the Hawaiian Islands. C1 TRIPLER ARMY MED CTR,DEPT MED,HONOLULU,HI 96859. TRIPLER ARMY MED CTR,DEPT PATHOL,HONOLULU,HI 96859. RP SAMLASKA, CP (reprint author), TRIPLER ARMY MED CTR,DERMATOL SERV,HONOLULU,HI 96859, USA. NR 23 TC 23 Z9 24 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD AUG PY 1992 VL 27 IS 2 BP 319 EP 322 DI 10.1016/0190-9622(92)70190-Q PN 2 PG 4 WC Dermatology SC Dermatology GA JG539 UT WOS:A1992JG53900011 PM 1517496 ER PT J AU ODONNELL, BP JAMES, WD AF ODONNELL, BP JAMES, WD TI RAPP-HODGKIN ECTODERMAL DYSPLASIA SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Article ID HAIR AB Rapp-Hodgkin syndrome is a rare condition that is characterized by ectodermal dysplasia and palatal abnormalities. We describe a 24-year-old white woman who has Rapp-Hodgkin syndrome that is associated with a chronic palmar keratoderma, which is a finding that has not been previously reported. We review the literature, assign the clinical features into major and minor categories, and suggest therapeutic interventions to limit the significant sequelae of this autosomal dominant syndrome. RP ODONNELL, BP (reprint author), WALTER REED ARMY MED CTR,DERMATOL SERV,WASHINGTON,DC 20307, USA. NR 16 TC 12 Z9 12 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD AUG PY 1992 VL 27 IS 2 BP 323 EP 326 DI 10.1016/0190-9622(92)70191-H PN 2 PG 4 WC Dermatology SC Dermatology GA JG539 UT WOS:A1992JG53900012 PM 1517497 ER PT J AU WRIGHT, TW OCKENDON, H AF WRIGHT, TW OCKENDON, H TI A MODEL FOR FULLY FORMED SHEAR BANDS SO JOURNAL OF THE MECHANICS AND PHYSICS OF SOLIDS LA English DT Article AB AN ASYMPTOTIC analysis of the morphology of a fully formed shear band is given for a simple flow law in a perfectly plastic material. Scaling laws are given for the maximum strain rate and the width of the band. C1 USA,BALLIST RES LABS,ABERDEEN PROVING GROUND,MD 21005. RP WRIGHT, TW (reprint author), UNIV OXFORD,INST MATH,24-29 ST GILES,OXFORD OX1 3LB,ENGLAND. NR 3 TC 44 Z9 51 U1 4 U2 9 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0022-5096 J9 J MECH PHYS SOLIDS JI J. Mech. Phys. Solids PD AUG PY 1992 VL 40 IS 6 BP 1217 EP 1226 DI 10.1016/0022-5096(92)90013-R PG 10 WC Materials Science, Multidisciplinary; Mechanics; Physics, Condensed Matter SC Materials Science; Mechanics; Physics GA JJ335 UT WOS:A1992JJ33500003 ER PT J AU CHOWDHURY, DQ HILL, SC BARBER, PW AF CHOWDHURY, DQ HILL, SC BARBER, PW TI TIME-DEPENDENCE OF INTERNAL INTENSITY OF A DIELECTRIC SPHERE ON AND NEAR RESONANCE SO JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION LA English DT Article ID STIMULATED RAMAN-SCATTERING; OPTICAL CAVITIES; RING CAVITY; DROPLETS; FIELD; MICROSPHERES; EMISSION; PARTICLE AB Transient intensities inside a large dielectric sphere (circumference/incident wavelength > 50) are computed for excitation with plane-wave pulses having a Gaussian time dependence. The center frequency of the pulse is either on or near a morphology-dependent resonance (MDR). For each internal point considered, the time dependence of the electric field is determined from the frequency spectrum of the field at that point. The frequency spectrum is the product of the incident field spectrum and the transfer function at that point. In a sphere both the internal spectrum and the associated time dependence vary with spatial location, particularly when the incident frequency is near a MDR. The time dependence of the intensity at an internal location near the surface shows an exponential tail with a time constant of 1/DELTA-omega(r), where DELTA-omega(r), is the resonant linewidth of the MDR, so long as the incident spectrum overlaps the MDR significantly, i.e., when DELTA-omega less-than-or-equal-to DELTA-omega-0 and DELTA-0mega-0 greater-than-or-equal-to DELTA-omega(r), where DELTA-omega-0 is the width of the incident pulse spectrum and DELTA-omega is the detuning, the difference between the MDR frequency and the center frequency of the incident Gaussian pulse. C1 YALE UNIV,CTR LASER DIAGNOST,NEW HAVEN,CT 06520. USA,ATMOSPHER SCI LAB,WHITE SANDS MISSILE RANGE,NM 88002. CLARKSON UNIV,DEPT ELECT & COMP ENGN,POTSDAM,NY 13699. RP CHOWDHURY, DQ (reprint author), YALE UNIV,DEPT APPL PHYS,NEW HAVEN,CT 06520, USA. NR 32 TC 29 Z9 31 U1 0 U2 2 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0740-3232 J9 J OPT SOC AM A JI J. Opt. Soc. Am. A-Opt. Image Sci. Vis. PD AUG PY 1992 VL 9 IS 8 BP 1364 EP 1373 DI 10.1364/JOSAA.9.001364 PG 10 WC Optics SC Optics GA JF103 UT WOS:A1992JF10300019 ER PT J AU SNODGRASS, HL METKER, LM AF SNODGRASS, HL METKER, LM TI DERMAL PENETRATION OF C-14-LABELED DIISOPROPYL METHYLPHOSPHONATE IN SWINE SO JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH LA English DT Article ID PERCUTANEOUS-ABSORPTION; SKIN; PIG AB Diisopropyl methylphosphonate (DIMP) has been identified as a groundwater contaminant on or near sites of former chemical warfare production facilities. The material is a by-product of GB (of Sarin) manufacture and does not occur naturally in the environment. The present study measured the dermal absorption of C-14-labeled DIMP in swine to establish the basis for estimating health risk from this portal of entry. Yorkshire cross swine were treated by sc injection of labeled DIMP to measure the efficiency of bioelimination. Additional pigs each received a single percutaneous (pc) exposure of 400, 40, or 4-mu-g/cm2 of labeled DIMP Absorption through 7 d was measured by the appearance of C-14 label in the urine and feces. Tissue specimens, collected at necropsy, were assessed for residual radioactivity The results showed that between 3 and 7% of cutaneous DIMP was absorbed through 7 d. Urinary elimination accounted for about 95% of the absorbed dose in the first 24 h. No significant tissue deposition was observed. Pigs treated by the sc route excreted nearly 100% of the injected material demonstrating an extremely efficient metabolic process. It was concluded that humans may be expected to absorb less than 10% of an unoccluded single dermal exposure to DIMP Absorbed dose would likely be metabolized to isopropyl methylphosphonic acid and excreted primarily in the urine within 24 h. Significant evaporation of the material from the open skin surface would be expected to occur. RP SNODGRASS, HL (reprint author), USA,ENVIRONM HYG AGCY,DIV TOXICOL,ABERDEEN PROVING GROUND,MD 21010, USA. NR 15 TC 0 Z9 0 U1 0 U2 4 PU TAYLOR & FRANCIS PI BRISTOL PA 1900 FROST ROAD, SUITE 101, BRISTOL, PA 19007-1598 SN 0098-4108 J9 J TOXICOL ENV HEALTH JI J. Toxicol. Environ. Health PD AUG PY 1992 VL 36 IS 4 BP 367 EP 376 PG 10 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA JJ880 UT WOS:A1992JJ88000007 PM 1507268 ER PT J AU THOMPSON, IM ZEIDMAN, EJ AF THOMPSON, IM ZEIDMAN, EJ TI CURRENT UROLOGICAL PRACTICE - ROUTINE UROLOGICAL EXAMINATION AND EARLY DETECTION OF CARCINOMA OF THE PROSTATE SO JOURNAL OF UROLOGY LA English DT Article DE PROSTATIC NEOPLASMS; ANTIGENS, NEOPLASM; DIAGNOSIS; CARCINOMA ID CANCER AB With the increasing incidence of carcinoma of the prostate, the interest in early diagnosis through screening has dramatically increased. Several organizations, including the American Urological Association (AUA) and the American Cancer Society, have promulgated recommendations on suggested early detection methods. To determine the current practice patterns of United States urologists, a survey was sent to a random sample of 10% of all urologist members of the AUA. The survey was designed to determine what are current recommendations for an annual urological checkup for older men, what tests should be included in screening for carcinoma of the prostate and what age groups of men should undergo prostate cancer screening. A total of 562 surveys was returned, constituting a 4.7% sample of all urologist members of the AUA. The use of digital rectal examination was unanimously recommended for the urological examination as well as for prostate cancer detection. Prostate specific antigen was recommended by a majority of respondents for both situations. Screening was recommended for men ages 50 to 80 years. Demographic factors had a significant role in clinical recommendations by urologists. C1 BROOKE ARMY MED CTR,DEPT CLIN INVEST,SAN ANTONIO,TX. RP THOMPSON, IM (reprint author), BROOKE ARMY MED CTR,DEPT SURG,UROL SERV,SAN ANTONIO,TX, USA. NR 9 TC 18 Z9 18 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-5347 J9 J UROLOGY JI J. Urol. PD AUG PY 1992 VL 148 IS 2 BP 326 EP 329 PN 1 PG 4 WC Urology & Nephrology SC Urology & Nephrology GA JF960 UT WOS:A1992JF96000025 PM 1635128 ER PT J AU DUCKETT, J PETERS, C MESROBIAN, G ELDER, J MANDELL, J RANSLEY, P STARR, N KOFF, S BELMAN, AB LEADBETTER, G MAIZELS, M KOGAN, B KIM, K SAWCZUK, I REITELMAN, C KASS, E SNOW, B KING, L RETIK, A AF DUCKETT, J PETERS, C MESROBIAN, G ELDER, J MANDELL, J RANSLEY, P STARR, N KOFF, S BELMAN, AB LEADBETTER, G MAIZELS, M KOGAN, B KIM, K SAWCZUK, I REITELMAN, C KASS, E SNOW, B KING, L RETIK, A TI OBSTRUCTION - DISCUSSION SO JOURNAL OF UROLOGY LA English DT Discussion C1 HARVARD UNIV, CHILDRENS HOSP, SCH MED, DEPT SURG, DIV UROL, BOSTON, MA 02115 USA. COLUMBIA UNIV COLL PHYS & SURG, DEPT UROL, NEW YORK, NY 10032 USA. UNIV TEXAS, DALLAS, TX 75230 USA. SOUTHWESTERN UNIV, DALLAS, TX USA. MED COLL WISCONSIN, DEPT UROL, MILWAUKEE, WI 53226 USA. CONNECT TISSUE RES INST, PHILADELPHIA, PA USA. UNIV N CAROLINA, DEPT SURG, PEDIAT UROL SECT, CHAPEL HILL, NC 27599 USA. CASE WESTERN RESERVE UNIV, RAINBOW BABIES & CHILDRENS HOSP, SCH MED, DEPT UROL, CLEVELAND, OH 44106 USA. UNIV N CAROLINA, DEPT CELL BIOL & ANAT, CHAPEL HILL, NC 27514 USA. CHILDRENS MEM HOSP, DEPT RADIOL, DIV UROL, CHICAGO, IL 60614 USA. NORTHWESTERN UNIV, SCH MED, DEPT UROL, CHICAGO, IL 60611 USA. CHILDRENS MEM HOSP, DEPT PATHOL, CHICAGO, IL 60614 USA. WILLIAM BEAUMONT HOSP, DEPT PEDIAT UROL, ROYAL OAK, MI 48072 USA. WILLIAM BEAUMONT HOSP, DEPT PEDIAT RADIOL, ROYAL OAK, MI 48072 USA. WILLIAM BEAUMONT HOSP, DEPT NUCL MED, ROYAL OAK, MI 48072 USA. UNIV CALIF SAN FRANCISCO, SCH MED, DEPT UROL, SAN FRANCISCO, CA 94143 USA. CHILDRENS HOSP, NATL MED CTR, DEPT PEDIAT UROL, WASHINGTON, DC 20010 USA. WALTER REED ARMY MED CTR, DEPT UROL, WASHINGTON, DC 20307 USA. COLUMBIA UNIV COLL PHYS & SURG, DEPT UROL, NEW YORK, NY 10032 USA. MAIMONIDES HOSP, DEPT UROL, BROOKLYN, NY 11219 USA. RP DUCKETT, J (reprint author), CHILDRENS HOSP PHILADELPHIA, DIV UROL, PHILADELPHIA, PA 19104 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0022-5347 EI 1527-3792 J9 J UROLOGY JI J. Urol. PD AUG PY 1992 VL 148 IS 2 BP 536 EP 538 PN 2 PG 3 WC Urology & Nephrology SC Urology & Nephrology GA JF961 UT WOS:A1992JF96100011 ER PT J AU BAUER, S PEREZ, L ZAONTZ, M DECTER, R RANSLEY, P KAPLAN, W GREENFIELD, S ATALA, A MASSAD, CA KHOURY, A RINK, R MESROBIAN, HG BARTONE, F RUSHTON, G SILLEN, U TANAGHO, E PARROTT, T DUCKETT, J KINAHAN, T WOODARD, J MAIZELS, M RICCIPETITONI, G KASS, E PERGAMENT, M REITELMAN, C AF BAUER, S PEREZ, L ZAONTZ, M DECTER, R RANSLEY, P KAPLAN, W GREENFIELD, S ATALA, A MASSAD, CA KHOURY, A RINK, R MESROBIAN, HG BARTONE, F RUSHTON, G SILLEN, U TANAGHO, E PARROTT, T DUCKETT, J KINAHAN, T WOODARD, J MAIZELS, M RICCIPETITONI, G KASS, E PERGAMENT, M REITELMAN, C TI URODYNAMICS IMAGING - DISCUSSION SO JOURNAL OF UROLOGY LA English DT Discussion C1 CHILDRENS HOSP MED CTR, DEPT NEUROL, BOSTON, MA 02115 USA. CHILDRENS HOSP MED CTR, DEPT NEUROSURG, BOSTON, MA 02115 USA. HARVARD UNIV, SCH MED, DEPT SURG, BOSTON, MA 02115 USA. HARVARD UNIV, SCH MED, DEPT MED, BOSTON, MA 02115 USA. PENN STATE UNIV, MILTON S HERSHEY MED CTR, DEPT SURG, DIV UROL, HERSHEY, PA 17033 USA. UNIV CALIF SAN DIEGO, MED CTR, DIV UROL, SAN DIEGO, CA 92103 USA. UNIV CALIF SAN DIEGO, MED CTR, CTR HLTH, SAN DIEGO, CA 92103 USA. CHILDRENS HOSP, DEPT PEDIAT UROL, SAN DIEGO, CA USA. CHILDRENS HOSP MED CTR, DIV UROL, BOSTON, MA 02115 USA. HARVARD UNIV, SCH MED, DEPT SURG, BOSTON, MA 02115 USA. CHILDRENS MEM HOSP, DEPT PEDIAT UROL, CHICAGO, IL 60614 USA. WESTCHESTER CTY MED CTR, VALHALLA, NY 10595 USA. CHILDRENS MEM HOSP, DEPT NEUROSURG, CHICAGO, IL 60614 USA. UNIV N CAROLINA, DEPT CELL BIOL & ANAT, CHAPEL HILL, NC 27514 USA. UNIV N CAROLINA, DEPT SURG, CHAPEL HILL, NC 27514 USA. EMORY UNIV, SCOTTISH RITES CHILDRENS HOSP, ATLANTA, GA 30322 USA. CHILDRENS HOSP MED CTR, DEPT UROL, BOSTON, MA 02115 USA. UNIV TEXAS, SW SCH MED, DIV PEDIAT NEPHROL, DALLAS, TX 75230 USA. KAISER PERMANENTE, LOS ANGELES, CA USA. NEW YORK MED COLL, VALHALLA, NY 10595 USA. UNIV IOWA, SCH MED, DEPT UROL, IOWA CITY, IA 52242 USA. CASE WESTERN RESERVE UNIV, RAINBOW BABIES & CHILDRENS HOSP, SCH MED, DEPT UROL, CLEVELAND, OH 44106 USA. UNIV PENN, CHILDRENS HOSP, SCH MED, DEPT UROL, PHILADELPHIA, PA 19104 USA. UNIV PENN, PHILADELPHIA, PA 19104 USA. CHILDRENS HOSP PHILADELPHIA, PHILADELPHIA, PA USA. CONNECT TISSUE RES INST, PHILADELPHIA, PA USA. UNIV PENN, CHILDRENS HOSP PHILADELPHIA, DIV UROL, PHILADELPHIA, PA 19104 USA. SEOUL NATL UNIV, CHILDRENS HOSP, COLL MED, DIV UROL, SEOUL 151, SOUTH KOREA. CHILDRENS MEM HOSP, DEPT RADIOL, DIV UROL, CHICAGO, IL 60614 USA. NORTHWESTERN UNIV, SCH MED, DEPT UROL, CHICAGO, IL 60611 USA. WILLIAM BEAUMONT HOSP, DEPT UROL, ROYAL OAK, MI 48072 USA. STANFORD UNIV, MED CTR, SCH MED, DEPT UROL, STANFORD, CA 94305 USA. UNIV FERRARA, S ANNA HOSP, DIV PEDIAT SURG, I-44100 FERRARA, ITALY. S GIACOMO EC HOSP, DIV PEDIAT, MASSA, ITALY. UNIV BOLOGNA, DIV PEDIAT SURG, I-40126 BOLOGNA, ITALY. UNIV FERRARA, DIV NEONATOL, I-44100 FERRARA, ITALY. UNIV FERRARA, DEPT PEDIAT, I-44100 FERRARA, ITALY. S GIACOMO EC HOSP, DEPT RADIOL, MASSA, ITALY. CHILDRENS HOSP, NATL MED CTR, DEPT PEDIAT UROL, WASHINGTON, DC 20010 USA. WALTER REED ARMY MED CTR, DEPT UROL, WASHINGTON, DC 20307 USA. EMORY UNIV, SCH MED, DEPT SURG UROL, ATLANTA, GA 30322 USA. SCOTTISH RITE CHILDRENS MED CTR, ATLANTA, GA USA. HOSP SICK CHILDREN, DEPT SURG, DIV UROL, TORONTO M5G 1X8, ONTARIO, CANADA. WALTER REED ARMY MED CTR, DEPT UROL, WASHINGTON, DC 20307 USA. CHILDRENS HOSP, NATL MED CTR, DEPT PEDIAT UROL, WASHINGTON, DC 20010 USA. CHILDRENS HOSP, DEPT PEDIAT SURG, GOTHENBURG, SWEDEN. UNIV CALIF SAN FRANCISCO, SCH MED, DEPT UROL, SAN FRANCISCO, CA 94143 USA. RP BAUER, S (reprint author), CHILDRENS HOSP MED CTR, DIV UROL, BOSTON, MA 02115 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA SN 0022-5347 J9 J UROLOGY JI J. Urol. PD AUG PY 1992 VL 148 IS 2 BP 615 EP 616 PN 2 PG 2 WC Urology & Nephrology SC Urology & Nephrology GA JF961 UT WOS:A1992JF96100032 ER PT J AU PLOTZKER, ED RUSHTON, HG BELMAN, AB SKOOG, SJ AF PLOTZKER, ED RUSHTON, HG BELMAN, AB SKOOG, SJ TI LAPAROSCOPY FOR NONPALPABLE TESTES IN CHILDHOOD - IS INGUINAL EXPLORATION ALSO NECESSARY WHEN VAS AND VESSELS EXIT THE INGUINAL RING SO JOURNAL OF UROLOGY LA English DT Article; Proceedings Paper CT 1991 ANNUAL MEETING OF THE SECTION OF UROLOGY OF THE AMERICAN ACADEMY OF PEDIATRICS CY OCT 26-31, 1991 CL NEW ORLEANS, LA SP AMER ACAD PEDIAT DE TESTIS; CRYPTORCHIDISM; PERITONEOSCOPY ID IMPALPABLE TESTIS; UNDESCENDED TESTES; MANAGEMENT; LOCALIZATION; BOYS AB Laparoscopy has proved to be a safe method for determining the status for nonpalpable testes. In a combined series 52 boys with 57 nonpalpable testes were evaluated laparoscopically. Of the 57 nonpalpable testes 26 were located above the internal inguinal ring (abdominal), 4 were found more distally, and blind-ending vas and vessels terminated in the abdomen in 3, and beyond the internal ring (vanished testes) in 24. Of 29 abdominal testes primary orchiopexy was performed in 15, 4 were removed, the vessels were transected (Fowler-Stephens) in 5, stage 1 of staged repairs was done in 2, distinct laparoscopic evidence of blind-ending vessels and vas obviated further surgery in 2, and testis was not identified either laparoscopically or by abdominal exploration. Finally, inguinal exploration in 28 children in whom vas and vessels were found to exit the internal ring resulted in localization of 4 testes that were brought into the scrotum. Removal of 23 testicular nubbins and their evaluation histologically resulted in identification of viable tubular structures in 3. We recommend inguinal exploration in all children who on laparoscopy are found to have vas and vessels exit the internal ring, and removal of testicular nubbins. C1 CHILDRENS HOSP,NATL MED CTR,DEPT PEDIAT UROL,111 MICHIGAN AVE NW,WASHINGTON,DC 20010. WALTER REED ARMY MED CTR,DEPT UROL,WASHINGTON,DC 20307. NR 20 TC 60 Z9 60 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-5347 J9 J UROLOGY JI J. Urol. PD AUG PY 1992 VL 148 IS 2 BP 635 EP 638 PN 2 PG 4 WC Urology & Nephrology SC Urology & Nephrology GA JF961 UT WOS:A1992JF96100039 PM 1353546 ER PT J AU PLOTZER, ED RUSHTON, HG BELMAN, AB SKOOG, SJ AF PLOTZER, ED RUSHTON, HG BELMAN, AB SKOOG, SJ TI LAPAROSCOPY FOR NONPALPABLE TESTES IN CHILDREN - IS INGUINAL EXPLORATION ALSO NECESSARY WHEN VAS AND VESSELS EXIT THE INGUINAL RING - REPLY SO JOURNAL OF UROLOGY LA English DT Editorial Material C1 CHILDRENS HOSP,NATL MED CTR,DEPT PEDIAT UROL,111 MICHIGAN AVE NW,WASHINGTON,DC 20010. WALTER REED ARMY MED CTR,DEPT UROL,WASHINGTON,DC 20307. NR 0 TC 1 Z9 1 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-5347 J9 J UROLOGY JI J. Urol. PD AUG PY 1992 VL 148 IS 2 BP 638 EP 638 PN 2 PG 1 WC Urology & Nephrology SC Urology & Nephrology GA JF961 UT WOS:A1992JF96100041 ER PT J AU PARROTT, T BASSIOUNY, I KRAMER, S RANSLEY, P BELMAN, AB EHRLICH, R RITCHEY, M BAUMANN, L HUSMANN, D KASS, E BROECKER, B BARTONE, F BARTHOLOMEW, T GILL, B DUCKETT, J SHORTLIFFE, L BAUER, SB RINK, R SCHERZ, H KOYLE, M RUSHTON, G MITCHELL, M KAPLAN, G HOULE, AM DEAN, W NGUYEN, D KHOURY, A HANNA, M MCLORIE, G SCHERZ, H AF PARROTT, T BASSIOUNY, I KRAMER, S RANSLEY, P BELMAN, AB EHRLICH, R RITCHEY, M BAUMANN, L HUSMANN, D KASS, E BROECKER, B BARTONE, F BARTHOLOMEW, T GILL, B DUCKETT, J SHORTLIFFE, L BAUER, SB RINK, R SCHERZ, H KOYLE, M RUSHTON, G MITCHELL, M KAPLAN, G HOULE, AM DEAN, W NGUYEN, D KHOURY, A HANNA, M MCLORIE, G SCHERZ, H TI OPERATIVE TECHNIQUE - DISCUSSION SO JOURNAL OF UROLOGY LA English DT Discussion C1 EMORY UNIV,EGLESTON CHILDRENS HOSP,ATLANTA,GA 30322. SCOTTISH RITE CHILDRENS MED CTR,ATLANTA,GA. AIN SHAMS UNIV,PEDIAT SURG UNIT,CAIRO,EGYPT. WALTER REED ARMY MED CTR,DEPT UROL,WASHINGTON,DC 20307. CHILDRENS HOSP,NATL MED CTR,DEPT PEDIAT UROL,WASHINGTON,DC 20010. MAYO CLIN & MAYO FDN,DEPT UROL,DIV NEPHROL & INTERNAL MED,ROCHESTER,MN 55905. MAYO CLIN & MAYO FDN,BIOSTAT SECT,ROCHESTER,MN 55905. MAYO CLIN,UROL SECT,SCOTTSDALE,AZ. UNIV PENN,CHILDRENS HOSP PHILADELPHIA,DIV UROL,PHILADELPHIA,PA 19104. CONNECT TISSUE RES INST,PHILADELPHIA,PA. WILFORD HALL USAF MED CTR,JOINT MIL MED COMMAND,DEPT UROL,LACKLAND AFB,TX 78236. WILFORD HALL USAF MED CTR,JOINT MIL MED COMMAND,CLIN INVEST DIRECTORATE,LACKLAND AFB,TX 78236. UNIV PENN,SCH MED,DIV PEDIAT UROL,PHILADELPHIA,PA 19104. UNIV PENN,SCH MED,DEPT SURG,PHILADELPHIA,PA 19104. UNIV PENN,SCH MED,DEPT UROL,PHILADELPHIA,PA 19104. KINDERSPITA,BASEL,SWITZERLAND. CHILDRENS HOSP PHILADELPHIA,PHILADELPHIA,PA. UNIV MED & DENT NEW JERSEY,SCH OSTEOPATH MED,DEPT PATHOL,CAMDEN,NJ. COLUMBIA PRESBYTERIAN MED CTR,BABIES HOSP,DIV PEDIAT UROL,NEW YORK,NY 10032. WILLIAM BEAUMONT HOSP,DEPT UROL,ROYAL OAK,MI 48072. STANFORD UNIV,MED CTR,SCH MED,DEPT UROL,STANFORD,CA 94305. UNIV CALIF SAN DIEGO,MED CTR,CTR MED & PHYSIOL CHEM,SAN DIEGO,CA 92103. UNIV CALIF SAN DIEGO,MED CTR,DIV UROL,SAN DIEGO,CA 92103. CHILDRENS HOSP,DEPT PEDIAT UROL,SAN DIEGO,CA. DUKE UNIV,S HOSP,MED CTR,DIV UROL,DURHAM,NC 27706. DUKE UNIV,MED CTR,DIV UROL,DURHAM,NC 27710. CHILDRENS HOSP,NATL MED CTR,WASHINGTON,DC 20010. WALTER REED ARMY MED CTR,DEPT UROL,WASHINGTON,DC 20307. RP PARROTT, T (reprint author), EMORY UNIV,SCH MED,DEPT SURG UROL,ATLANTA,GA 30322, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-5347 J9 J UROLOGY JI J. Urol. PD AUG PY 1992 VL 148 IS 2 BP 711 EP 713 PN 2 PG 3 WC Urology & Nephrology SC Urology & Nephrology GA JF961 UT WOS:A1992JF96100065 ER PT J AU WISWELL, TE AF WISWELL, TE TI PREPUCE PRESENCE PORTENDS PREVALENCE OF POTENTIALLY PERILOUS PERIURETHRAL PATHOGENS SO JOURNAL OF UROLOGY LA English DT Article; Proceedings Paper CT 1991 ANNUAL MEETING OF THE SECTION OF UROLOGY OF THE AMERICAN ACADEMY OF PEDIATRICS CY OCT 26-31, 1991 CL NEW ORLEANS, LA SP AMER ACAD PEDIAT DE PENIS; CIRCUMCISION; URINARY TRACT INFECTIONS ID URINARY-TRACT INFECTIONS; CIRCUMCIZED MALE INFANTS; DECREASED INCIDENCE; LIFE; BACTERIAL; FEMALE; AFRICA; MEN RP WISWELL, TE (reprint author), WALTER REED ARMY MED CTR,DEPT PEDIAT,NEONATOL SERV,WASHINGTON,DC 20307, USA. NR 34 TC 25 Z9 26 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-5347 J9 J UROLOGY JI J. Urol. PD AUG PY 1992 VL 148 IS 2 BP 739 EP 742 PN 2 PG 4 WC Urology & Nephrology SC Urology & Nephrology GA JF961 UT WOS:A1992JF96100072 PM 1386390 ER PT J AU TYSON, SE AF TYSON, SE TI 17-PERCENT CHROMIUM MINIMUM FOR TYPE-304 STAINLESS-STEEL STANDARDS SO MATERIALS PERFORMANCE LA English DT Editorial Material RP TYSON, SE (reprint author), USA,203 SPRING CREST BLVD,SINKING SPRING,PA 19608, USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU NATL ASSN CORROSION ENG PI HOUSTON PA 1440 SOUTH CREEK DRIVE, HOUSTON, TX 77084-4906 SN 0094-1492 J9 MATER PERFORMANCE JI Mater. Perform. PD AUG PY 1992 VL 31 IS 8 BP 5 EP 5 PG 1 WC Materials Science, Characterization & Testing SC Materials Science GA JK906 UT WOS:A1992JK90600001 ER PT J AU ZABIELSKI, CV LEVY, M AF ZABIELSKI, CV LEVY, M TI STUDY OF TYPE-II AND TYPE-III ANODIZED AL-5052-0 IN AQUEOUS DS2 SOLUTIONS SO MATERIALS PERFORMANCE LA English DT Article AB Corrosion behavior studies using short-time electrochemical techniques and long-term immersion tests of Types II and III anodized Al 5052-0 and uncoated Al 5052-0 were conducted in 30 vol% DS2 aqueous decontaminating solution. Test data indicated that Type III anodized Al 5052-0 provided significantly greater resistance to degradation than Type II anodized Al 5052-0 or uncoated Al 5052-0. RP ZABIELSKI, CV (reprint author), USA,MAT TECHNOL LAB,WATERTOWN,MA 02172, USA. NR 2 TC 0 Z9 0 U1 0 U2 0 PU NATL ASSN CORROSION ENG PI HOUSTON PA 1440 SOUTH CREEK DRIVE, HOUSTON, TX 77084-4906 SN 0094-1492 J9 MATER PERFORMANCE JI Mater. Perform. PD AUG PY 1992 VL 31 IS 8 BP 45 EP 49 PG 5 WC Materials Science, Characterization & Testing SC Materials Science GA JK906 UT WOS:A1992JK90600010 ER PT J AU LANDE, RG AF LANDE, RG TI MILITARY PSYCHIATRY AND THE CRIMINAL-LAW SO MILITARY MEDICINE LA English DT Article AB This article provides guidance in performing clinical psychiatric evaluations of the criminally accused. The interface between thc law and psychiatry raises difficult dilemmas. Through a review of military regulations and relevant case law, suggestions are provided to enhance the clinician's control, quality, and value of contribution. The clinician's need for complete disclosure from the accused soldier, in order to ensure a thorough forensic assessment, may conflict with legal concerns. The accused and the military justice system must consider specific issues, such as confidentiality and compliance. This article discusses thc practical ramifications and implications of these issues. RP LANDE, RG (reprint author), WALTER REED ARMY MED CTR,DEPT PSYCHIAT,WASHINGTON,DC 20307, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD AUG PY 1992 VL 157 IS 8 BP 392 EP 397 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA JJ502 UT WOS:A1992JJ50200010 PM 1528482 ER PT J AU POWERS, J KERCHIEF, K FRANKLIN, K AF POWERS, J KERCHIEF, K FRANKLIN, K TI PATTERNS OF ACCREDITATION PERFORMANCE IN ARMY FAMILY-PRACTICE RESIDENCIES SO MILITARY MEDICINE LA English DT Article AB Army leadership emphasizes training in all segments of its population, including family medicine. Standards for medical professional training, however, are provided by a civilian agency, the Accreditation Council for Graduate Medical Education (ACGME). In order to search for performance patterns, the authors reviewed the last two accreditation documents of each Army Family Practice residency. After independently scoring the documents against the written standards, the scores were compared with the actual written findings from the ACGME Residency Review Committee. The authors discuss patterns and trends resulting from this analysis, and recommend areas for future growth in the military training of family physicians. RP POWERS, J (reprint author), USA,COMMAND & GEN STAFF COLL,DEPT SUSTAINING & RESOURCE OPERAT,FT LEAVENWORTH,KS, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD AUG PY 1992 VL 157 IS 8 BP 409 EP 414 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA JJ502 UT WOS:A1992JJ50200015 PM 1528487 ER PT J AU RITCHIE, EC AF RITCHIE, EC TI GAS MASK PHOBIA - REPLY SO MILITARY MEDICINE LA English DT Letter RP RITCHIE, EC (reprint author), WALTER REED ARMY MED CTR,DEPT PSYCHIAT,WASHINGTON,DC 20307, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD AUG PY 1992 VL 157 IS 8 BP A11 EP A11 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA JJ502 UT WOS:A1992JJ50200008 ER PT J AU OU, JT HUANG, CJ HOUNG, HSH BARON, LS AF OU, JT HUANG, CJ HOUNG, HSH BARON, LS TI ROLE OF IS1 IN THE CONVERSION OF VIRULENCE (VI) ANTIGEN EXPRESSION IN ENTEROBACTERIACEAE SO MOLECULAR & GENERAL GENETICS LA English DT Article DE VI ANTIGEN; IS1; INSERTION; GENE EXPRESSION; DNA-DNA HYBRIDIZATION ID ESCHERICHIA-COLI; DNA; FRAGMENTS; SEQUENCES; GAL AB When Escherichia coli HB101 harbors pWR127, a plasmid comprising the viaB gene from Citrobacter freundii WR7004 and the ColE1-derived pACKCI, the strain produces the virulence (Vi) antigen. Vi antigen expression is abolished (Vi- phenotype), however, when an IS1 or IS1-like DNA element inserts into the viaB region. To determine the sites of IS1 insertion, pWRI27 DNAs extracted from 95 independently isolated Vi- strains were analyzed by digestion with the restriction endonuclease PstI and agarose gel electrophoresis. Ten insertion sites were found distributed nonrandomly in an area of about 1.3 kb. Nine Vi+ strains (two Citrobacter, two E. coli, and five Salmonella strains), four of which contain pWR127, were then tested for the presence of IS1 by DNA-DNA hybridization. Of the nine strains, five were stable Vi+ and did not contain IS1. The other four which generated Vi- strains, contained IS1. When pRR134, a plasmid that contains IS1 was transferred into a stable Vi+ Salmonella typhimurium strain carrying pWRI27 (OU5140), Vi- strains were produced from which pWRI27 derivatives carrying IS1 inserts could be isolated. It appears, therefore, that the presence of an IS1 or IS1-like element in a strain is required for conversion of the Vi+ expression state to the Vi- expression state. C1 WALTER REED ARMY MED CTR,DEPT BACTERIAL IMMUNOL,WASHINGTON,DC 20512. RP OU, JT (reprint author), CHANG GUNG MED COLL,DEPT MICROBIOL & IMMUNOL,KWEISHAN 33332,TAIWAN. NR 21 TC 4 Z9 4 U1 0 U2 0 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0026-8925 J9 MOL GEN GENET JI Mol. Gen. Genet. PD AUG PY 1992 VL 234 IS 2 BP 228 EP 232 PG 5 WC Biochemistry & Molecular Biology; Genetics & Heredity SC Biochemistry & Molecular Biology; Genetics & Heredity GA JJ688 UT WOS:A1992JJ68800008 PM 1324399 ER PT J AU CHOI, MYS AF CHOI, MYS TI SERUM ENZYME MONITORING IN ASTHMA PATIENTS SO PEDIATRICS LA English DT Letter C1 WOMACK ARMY MED CTR,DEPT PEDIAT,FT BRAGG,NC 28307. RP CHOI, MYS (reprint author), WOMACK ARMY MED CTR,DEPT MED,FT BRAGG,NC 28307, USA. NR 4 TC 1 Z9 1 U1 0 U2 0 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD, ELK GROVE VILLAGE, IL 60007-1098 SN 0031-4005 J9 PEDIATRICS JI Pediatrics PD AUG PY 1992 VL 90 IS 2 BP 279 EP 280 PN 1 PG 2 WC Pediatrics SC Pediatrics GA JG577 UT WOS:A1992JG57700030 ER PT J AU WILLIAMSON, AN AF WILLIAMSON, AN TI MAP SCANNING FOR GIS APPLICATIONS SO PHOTOGRAMMETRIC ENGINEERING AND REMOTE SENSING LA English DT Article AB Recent improvements in optical document scanning systems greatly increase the attractiveness of this technology as a cost effective tool for satisfying the enormous appetite for information that is characteristic of today's geographic information systems (GIS). However, effective use of this technology necessitates a basic understanding of the different scanner types, how they function, data forms, and the information content of scanner output files. This paper presents an overview of scanners, their use for digitizing information for input to a GIS, and some essential software tools for effective use of scanned data for GIS input. RP WILLIAMSON, AN (reprint author), USA,ENGN WATERWAYS EXPT STN,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 3 TC 0 Z9 0 U1 0 U2 1 PU AMER SOC PHOTOGRAMMETRY PI BETHESDA PA 5410 GROSVENOR LANE SUITE 210, BETHESDA, MD 20814-2160 SN 0099-1112 J9 PHOTOGRAMM ENG REM S JI Photogramm. Eng. Remote Sens. PD AUG PY 1992 VL 58 IS 8 BP 1199 EP 1202 PG 4 WC Geography, Physical; Geosciences, Multidisciplinary; Remote Sensing; Imaging Science & Photographic Technology SC Physical Geography; Geology; Remote Sensing; Imaging Science & Photographic Technology GA JF232 UT WOS:A1992JF23200048 ER PT J AU ALBERTSON, PE BOURNE, SG HENNINGTON, GW AF ALBERTSON, PE BOURNE, SG HENNINGTON, GW TI AN INTEGRATED GROUNDWATER AND LAND-USE GIS FOR IMPACT ASSESSMENT SO PHOTOGRAMMETRIC ENGINEERING AND REMOTE SENSING LA English DT Article AB Groundwater problems have been traditionally solved with graphic techniques. This study demonstrates the application of emerging geographic information system (GIS) technology to the solution of groundwater impact assessment problems. This application of GIS focuses nn the area around Alexandria, Louisiana, along the Red River. The integrated data set of groundwater levels and land-use types allow for efficient and objective assessment of postproject impacts. The methodology will interest GIS practitioners because it integrates ERDAS and Intergraph data formats. Unsupervised and supervised state-of-the-art remote sensing techniques classified Landsat data into the land-use types. The workflow also includes tablet and heads up digitizing, vector-to-raster conversions, inputting ASCII data, and generating triangulated irregular networks (TIN) models. Analysis of the data sets applies Boolean logic. The graphic results prove that GIS is a powerful tool for environmental and hydrogeological scientists. RP ALBERTSON, PE (reprint author), USA,ENGN WATERWAYS EXPT STN,VICKSBURG,MS 39180, USA. NR 13 TC 1 Z9 1 U1 0 U2 0 PU AMER SOC PHOTOGRAMMETRY PI BETHESDA PA 5410 GROSVENOR LANE SUITE 210, BETHESDA, MD 20814-2160 SN 0099-1112 J9 PHOTOGRAMM ENG REM S JI Photogramm. Eng. Remote Sens. PD AUG PY 1992 VL 58 IS 8 BP 1203 EP 1207 PG 5 WC Geography, Physical; Geosciences, Multidisciplinary; Remote Sensing; Imaging Science & Photographic Technology SC Physical Geography; Geology; Remote Sensing; Imaging Science & Photographic Technology GA JF232 UT WOS:A1992JF23200049 ER PT J AU NAUGLE, BI LASHLEE, JD AF NAUGLE, BI LASHLEE, JD TI ALLEVIATING TOPOGRAPHIC INFLUENCES ON LAND-COVER CLASSIFICATIONS FOR MOBILITY AND COMBAT MODELING SO PHOTOGRAMMETRIC ENGINEERING AND REMOTE SENSING LA English DT Article AB Techniques were applied to alleviate topographic influences on a TM scene prior to land-cover classification for mobility modeling. Illumination models were created using two different resolutions of DEM data. These illumination models were based on linear regression of the two parts (cosine and sine) of the equation for the incidence angle of the solar beam with the first principal component of the TM data. A topographic normalization procedure was applied to correct the TM data utilizing the derived models. The near IR band required a completely different model because of high correlation between areas of high relief and vigorously growing vegetation. Results are presented showing improved utility for visual interpretation and land-cover classification on the corrected data. C1 USA,CORPS ENGN WATERWAYS EXPT STN,VICKSBURG,MS 39180. RP NAUGLE, BI (reprint author), MURRAY STATE UNIV,CTR MIDAMER REMOTE SENSING,MURRAY,KY 42071, USA. NR 6 TC 10 Z9 10 U1 1 U2 1 PU AMER SOC PHOTOGRAMMETRY PI BETHESDA PA 5410 GROSVENOR LANE SUITE 210, BETHESDA, MD 20814-2160 SN 0099-1112 J9 PHOTOGRAMM ENG REM S JI Photogramm. Eng. Remote Sens. PD AUG PY 1992 VL 58 IS 8 BP 1217 EP 1221 PG 5 WC Geography, Physical; Geosciences, Multidisciplinary; Remote Sensing; Imaging Science & Photographic Technology SC Physical Geography; Geology; Remote Sensing; Imaging Science & Photographic Technology GA JF232 UT WOS:A1992JF23200053 ER PT J AU LASHLEE, JD ROBINSON, JH AF LASHLEE, JD ROBINSON, JH TI TACTICAL MOBILITY MODELING FOR REFORGER 87 SO PHOTOGRAMMETRIC ENGINEERING AND REMOTE SENSING LA English DT Article AB The Waterways Experiment Station (WES) responded to requests by the U.S. Army III Corps, 64th Engineer Detachment (Terrain) by providing trafficability support for the REFORGER 87 military exercises in the Federal Republic of Germany. The maneuver area covered 25 1:50,000-scale topographic map sheets. A digital mobility database was developed within a period of one month. A principal source of information was Landsat Thematic Mapper (TM) data, which was integrated with various other digital factor maps necessary for computer modeling of vehicle mobility. The Condensed Army Mobility Model System (CAMMS) was used to evaluate the performance of specified vehicles operating off-road in the maneuver area. CAMMS correctly predicted a NOGO situation for an area where several U.S. armored vehicles were immobilized when a gravel road failed and the vehicles were unable to traverse the surrounding organic clay soil and associated drainage ditches. RP LASHLEE, JD (reprint author), USA,ENGN WATERWAYS EXPT STN,VICKSBURG,MS 39180, USA. NR 9 TC 1 Z9 1 U1 1 U2 1 PU AMER SOC PHOTOGRAMMETRY PI BETHESDA PA 5410 GROSVENOR LANE SUITE 210, BETHESDA, MD 20814-2160 SN 0099-1112 J9 PHOTOGRAMM ENG REM S JI Photogramm. Eng. Remote Sens. PD AUG PY 1992 VL 58 IS 8 BP 1223 EP 1227 PG 5 WC Geography, Physical; Geosciences, Multidisciplinary; Remote Sensing; Imaging Science & Photographic Technology SC Physical Geography; Geology; Remote Sensing; Imaging Science & Photographic Technology GA JF232 UT WOS:A1992JF23200054 ER PT J AU RAI, J BOWDEN, CM AF RAI, J BOWDEN, CM TI QUANTUM-STATISTICAL ANALYSIS OF SUPERFLUORESCENCE AND AMPLIFIED SPONTANEOUS EMISSION IN DENSE MEDIA SO PHYSICAL REVIEW A LA English DT Article ID COOPERATIVE RADIATION PROCESSES; SPONTANEOUS GENERATION; SIGNAL AMPLIFICATION; OPTICAL BISTABILITY; 2-LEVEL SYSTEMS; SUPER-RADIANCE; FLUCTUATIONS; LASER; SCATTERING; SOLITONS AB We have studied the quantum-statistical properties of superfluorescence (SF) and amplified spontaneous emission (ASE) for dense media (media of densities corresponding to many atoms, on the average, within a cubic resonance wavelength). We use the Langevin equations of motion, obtained from a fully quantized model that takes into account induced near dipole-dipole interactions associated with dense media, together with the coupled Maxwell equation, to formulate a stochastic calculation ensemble. Quantum Monte Carlo methods are used in conjunction with the stochastic model, to conduct a statistical analysis of phase waves for this system. Results are presented for the phase-wave density, delay time, and peak-intensity fluctuations. The transition from SF to ASE is treated using the stochastic model. C1 USA,MISSILE COMMAND,CTR RES DEV & ENGN,WEAPONS SCI DIRECTORATE,AMSMI RD WS ST,REDSTONE ARSENAL,AL 35898. RP RAI, J (reprint author), INDIAN INST TECHNOL,DEPT PHYS,KANPUR 208016,UTTAR PRADESH,INDIA. NR 47 TC 15 Z9 16 U1 0 U2 5 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1050-2947 J9 PHYS REV A JI Phys. Rev. A PD AUG 1 PY 1992 VL 46 IS 3 BP 1522 EP 1529 DI 10.1103/PhysRevA.46.1522 PG 8 WC Optics; Physics, Atomic, Molecular & Chemical SC Optics; Physics GA JH411 UT WOS:A1992JH41100047 ER PT J AU BARNES, E ASHWORTH, K AF BARNES, E ASHWORTH, K TI BIOARCHAEOLOGY OF SOME PLAINS WOODLAND BURIALS FROM WAURIKA LAKE, SOUTHWEST OKLAHOMA SO PLAINS ANTHROPOLOGIST LA English DT Article ID POPULATIONS; TRACHOMA; GROOVES AB Skeletal remains from Site 34ST2, Waurika Lake, Oklahoma, represent three prehistoric individuals, one child, one adult male, and one adult female Cultural material from this site indicates a probable Plains Woodland cultural affiliation. Raw materials for some of the stone artifacts were brought from locations 50 to 100 miles away, suggesting either some form of cultural exchange ora highly mobile subsistence pattern. Interproximal grooving of the teeth of the adult male reflects functional stress most likely associated with the stripping of animal sinews. A very unusual boney lesion in the left eye orbit of the adult female suggests she suffered from trachoma, a chronic, blinding eye disease. This represents the only case as yet reported outside of Australia. C1 USA,CORPS ENGINEERS,ENVIRONM RESOURCES BRANCH,TULSA,OK. NR 23 TC 1 Z9 1 U1 1 U2 3 PU PLAINS ANTHROPOLOGICAL SOC PI LINCOLN PA 410 WEDGEWOOD DRIVE, LINCOLN, NE 68510 SN 0032-0447 J9 PLAINS ANTHROPOL JI Plains Anthropol. PD AUG PY 1992 VL 37 IS 140 BP 233 EP 246 PG 14 WC Anthropology SC Anthropology GA JM031 UT WOS:A1992JM03100003 ER PT J AU CAROME, MA MOORE, J AF CAROME, MA MOORE, J TI NEPHROTIC SYNDROME IN ADULTS - A DIAGNOSTIC AND MANAGEMENT CHALLENGE SO POSTGRADUATE MEDICINE LA English DT Article ID PROTEINURIA AB The adult with nephrotic syndrome presents diagnostic and treatment challenges for the primary care physician. Early consultation with a nephrologist is advisable to assist in choosing between empirical therapy or renal biopsy to identify the specific causative lesion. Some patients respond to treatment of either the specific disorder or the underlying cause. All patients should be afforded specific therapy, where available, and nonspecific therapy to minimize the severity of the nephrosis and attenuate the incidence and severity of complications. Although the cause of most disorders resulting in nephrotic syndrome remains unclear, active research into the syndrome's pathogenesis and treatment options should prove fruitful. C1 USA,MED CORPS,WASHINGTON,DC 20310. UNIFORMED SERV UNIV HLTH SCI,MED,BETHESDA,MD 20814. RP CAROME, MA (reprint author), WALTER REED ARMY MED CTR,DEPT MED,NEPHROL SERV,WASHINGTON,DC 20307, USA. NR 20 TC 3 Z9 3 U1 0 U2 0 PU MCGRAW HILL HEALTHCARE PUBLICATIONS PI MINNEAPOLIS PA 4530 WEST 77TH ST, MINNEAPOLIS, MN 55435-5000 SN 0032-5481 J9 POSTGRAD MED JI Postgrad. Med. PD AUG PY 1992 VL 92 IS 2 BP 209 EP & PG 0 WC Medicine, General & Internal SC General & Internal Medicine GA JJ129 UT WOS:A1992JJ12900019 PM 1495878 ER PT J AU ADAMS, JH SIM, BKL DOLAN, SA FANG, XD KASLOW, DC MILLER, LH AF ADAMS, JH SIM, BKL DOLAN, SA FANG, XD KASLOW, DC MILLER, LH TI A FAMILY OF ERYTHROCYTE BINDING-PROTEINS OF MALARIA PARASITES SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE PLASMODIUM; INVASION; ADHESINS; DUFFY BLOOD GROUP ANTIGEN; SIALIC ACID ID RECOMBINANT VACCINIA VIRUS; PLASMODIUM-FALCIPARUM; CIRCUMSPOROZOITE PROTEIN; ANTIGEN; KNOWLESI; MEROZOITES; INVASION; SURFACE; IDENTIFICATION; GLYCOPROTEIN AB Malaria erythrocyte binding proteins use the Duffy blood group antigen (Plasmodium vivax and Plasmodium knowlesi) and sialic acid (Plasmodium falciparum) on the erythrocyte surface as receptors. We had previously cloned the one P. vivax gene, the one P. falciparum gene, and part of one of the three P. knowlesi genes encoding these erythrocyte binding proteins and described the homology between the P. knowlesi and P. vivax genes. We have completed the cloning and sequencing of the three P. knowlesi genes and identified introns in the P. vivax and P. falciparum genes that correct the previously published deduced amino acid sequences. All have similar structures, with one or two exons encoding the signal sequence and the erythrocyte binding domain, an exon encoding the transmembrane domain, and two exons encoding the cytoplasmic domain with the exception of the P. knowlesi beta-gene. The regions of amino acid sequence homology among all the genes are the 5' and 3' cysteine-rich regions of the erythrocyte binding domain. On the basis of gene structure and amino acid homology, we propose that the Duffy binding proteins and the sialic acid binding protein are members of a gene family. The level of conservation (almost-equal-to 70%) of the deduced amino acid sequences in the 5' cysteine-rich region between the P. vivax protein and the three P. knowlesi proteins is as great as between the three P. knowlesi proteins themselves; the P. knowlesi beta-protein just 3' to this cysteine-rich region is homologous to the P. vivax protein but not to the other P. knowlesi proteins. Conservation of amino acid sequences among these organisms, separated in evolution, may indicate the regions where the adhesin function resides. C1 UNIV NOTRE DAME,DEPT BIOL SCI,NOTRE DAME,IN 46556. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. JOHNS HOPKINS UNIV,BALTIMORE,MD 21205. RP ADAMS, JH (reprint author), NIAID,MALARIA RES LAB,BETHESDA,MD 20892, USA. RI Adams, John/G-1800-2015 OI Adams, John/0000-0003-3707-7979 NR 31 TC 340 Z9 351 U1 2 U2 8 PU NATL ACAD PRESS PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD AUG 1 PY 1992 VL 89 IS 15 BP 7085 EP 7089 DI 10.1073/pnas.89.15.7085 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA JF856 UT WOS:A1992JF85600088 PM 1496004 ER PT J AU HAM, RC AF HAM, RC TI WAR AND THE CITY - ASHWORTH,GJ SO PROFESSIONAL GEOGRAPHER LA English DT Book Review DE MILITARY GEOGRAPHY; URBAN DEFENSE; FORTIFICATIONS; URBAN CRIME; URBAN GUERRILLA; DEFENSE HERITAGE RP HAM, RC (reprint author), US MIL ACAD,W POINT,NY 10996, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU BLACKWELL PUBLISHERS PI CAMBRIDGE PA 350 MAIN STREET, STE 6, CAMBRIDGE, MA 02148-5023 SN 0033-0124 J9 PROF GEOGR JI Prof. Geogr. PD AUG PY 1992 VL 44 IS 3 BP 349 EP 350 PG 2 WC Geography SC Geography GA JJ222 UT WOS:A1992JJ22200011 ER PT J AU PITTS, RM CHOATE, JR SMOLEN, MJ AF PITTS, RM CHOATE, JR SMOLEN, MJ TI WINTER BREEDING BY GEOMYS-BREVICEPS SO TEXAS JOURNAL OF SCIENCE LA English DT Note RP PITTS, RM (reprint author), ARMY RESERVE PERSONNEL CTR,OPC,POB 32466,ST LOUIS,MO 63132, USA. NR 0 TC 3 Z9 3 U1 0 U2 0 PU TEXAS ACAD SCI PI LUBBOCK PA TEXAS TECH UNIV, LUBBOCK, TX 79401 SN 0040-4403 J9 TEX J SCI JI Tex. J. Sci. PD AUG PY 1992 VL 44 IS 3 BP 370 EP 371 PG 2 WC Ecology; Zoology SC Environmental Sciences & Ecology; Zoology GA JH668 UT WOS:A1992JH66800017 ER PT J AU MAGZOUB, MMA STEPHENS, HAF SACHS, JA BIRO, PA CUTBUSH, S WU, Z BOTTAZZO, GF AF MAGZOUB, MMA STEPHENS, HAF SACHS, JA BIRO, PA CUTBUSH, S WU, Z BOTTAZZO, GF TI HLA-DP POLYMORPHISM IN SUDANESE CONTROLS AND PATIENTS WITH INSULIN-DEPENDENT DIABETES-MELLITUS SO TISSUE ANTIGENS LA English DT Article DE HLA-DP POLYMORPHISM; IDDM; SUDANESE; OLIGOTYPING ID JUVENILE RHEUMATOID-ARTHRITIS; FRAGMENT LENGTH POLYMORPHISM; MULTIPLE-SCLEROSIS; PLT-REAGENTS; ANTIGENS; BETA; SUSCEPTIBILITY; GENE; DISEASE; DQ AB Human leukocyte antigen (HLA) genes are candidates for susceptibility to insulin-dependent diabetes mellitus (IDDM). The association of IDDM with particular DR and DQ alleles has been reported in all populations studied, but its association with HLA-DP alleles has been controversial. To address this question we analyzed 19 DPB1 and 2 DPA1 alleles and their associations in well-characterized Sudanese (an admixture of Arab and Black) IDDM patients (n = 71) and ethnically matched controls (n = 86) using polymerase chain reaction-sequence specific oligonucleotide (PCR-SSO) typing. There were no significant differences between the patient and control groups in the DPB1 frequencies. DPB1*0201, *0401 and DPA1*01 were the most frequent alleles in both IDDM patients and control subjects. Significant positive and negative associations between DPB1 and DPA1 alleles were detected in both groups. A novel DPB1 allele included in DPB1*1701 was identified. C1 UNIV LONDON LONDON HOSP,COLL MED,DEPT IMMUNOL,TURNER ST,LONDON E1 2AD,ENGLAND. UNIV GEZIRA,FAC MED,KHARTOUM,SUDAN. ARMED FORCES RES INST MED SCI,DEPT IMMUNOL,BANGKOK,THAILAND. NR 37 TC 16 Z9 16 U1 0 U2 0 PU MUNKSGAARD INT PUBL LTD PI COPENHAGEN PA 35 NORRE SOGADE, PO BOX 2148, DK-1016 COPENHAGEN, DENMARK SN 0001-2815 J9 TISSUE ANTIGENS JI Tissue Antigens PD AUG PY 1992 VL 40 IS 2 BP 64 EP 68 DI 10.1111/j.1399-0039.1992.tb01961.x PG 5 WC Cell Biology; Immunology; Pathology SC Cell Biology; Immunology; Pathology GA JH207 UT WOS:A1992JH20700002 PM 1412418 ER PT J AU HILASKI, R KATZ, S SALEM, H AF HILASKI, R KATZ, S SALEM, H TI INHALATION TOXICITY OF CHROMIUM FROM WHETLERITE DUST IN RATS SO TOXICOLOGY LETTERS LA English DT Article DE CHROMIUM; COPPER; WHETLERITE DUST; OECD LIMIT TEST; INHALATION; RAT ID BIOLOGICAL AVAILABILITY; OCCUPATIONAL-HEALTH; PAINT AEROSOL; CARCINOGENICITY; LEAD AB The acute inhalation toxicity and metabolic fate of chromium and copper from Whetlerite dust in rats were investigated. Groups of male and female, Sprague-Dawley rats were exposed to Whetlerite dust and base carbon dust as outlined in the OECD Limit Test guidelines. At 14, 28 and 180 days post-exposure, rats were evaluated for gross pathological changes and tissues were collected for chromium and copper determination. Four deaths occurred during or post-exposure, but did not appear to be compound related. No gross pathological changes were observed at necropsy in either group. Organ chromium concentrations were below detection limits of 0.5-mu-g Cr/g dry tissue in both exposure groups. According to OECD guidelines, neither Whetlerite dust nor base carbon dust demonstrated an acute inhalation toxicity. C1 RUTGERS STATE UNIV,DEPT CHEM,CAMDEN,NJ 08102. RP HILASKI, R (reprint author), USA,CTR CHEM RES DEV & ENGN,DIV TOXICOL,SMCCR RST I,ABERDEEN PROVING GROUND,MD 21010, USA. NR 25 TC 1 Z9 1 U1 0 U2 0 PU ELSEVIER SCI IRELAND LTD PI CLARE PA CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE, IRELAND SN 0378-4274 J9 TOXICOL LETT JI Toxicol. Lett. PD AUG PY 1992 VL 62 IS 1 BP 25 EP 31 DI 10.1016/0378-4274(92)90074-T PG 7 WC Toxicology SC Toxicology GA JJ741 UT WOS:A1992JJ74100004 PM 1509503 ER PT J AU DOEBLER, JA MARTIN, LJ MORSE, JD BALLOUGH, GP STRAUSS, JA ANTHONY, A AF DOEBLER, JA MARTIN, LJ MORSE, JD BALLOUGH, GP STRAUSS, JA ANTHONY, A TI MESENTERIC MAST-CELL DEGRANULATION IN ACUTE T-2 TOXIN POISONING SO TOXICOLOGY LETTERS LA English DT Article DE T-2 TOXIN; RAT; MAST CELL; METACHROMASIA ID RATS AB T-2 toxin-induced alterations in rat mesenteric mast cell granulation were measured by cytophotometric analyses of the metachromatic reaction of mast cell granules with azure B. Hypogranulation (diminution of metachromatic material) was observed 8 h following injections of T-2 toxin (0.5-1.5 LD50, i.p.). These data suggest that mast cell activation occurs during acute T-2 intoxication and raise the possibility that mast cell mediators may contribute to toxin-induced cardiovascular collapse. C1 PENN STATE UNIV,DEPT BIOL,PHYSIOL LABS,UNIV PK,PA 16802. RP DOEBLER, JA (reprint author), USA,MED RES INST CHEM DEF,BLDG E-3100,EDGEWOOD AREA,ABERDEEN PROVING GROUND,MD 21010, USA. NR 14 TC 4 Z9 4 U1 0 U2 0 PU ELSEVIER SCI IRELAND LTD PI CLARE PA CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE, IRELAND SN 0378-4274 J9 TOXICOL LETT JI Toxicol. Lett. PD AUG PY 1992 VL 62 IS 1 BP 33 EP 38 DI 10.1016/0378-4274(92)90075-U PG 6 WC Toxicology SC Toxicology GA JJ741 UT WOS:A1992JJ74100005 PM 1509504 ER PT J AU SATORIUS, EH MULLIGAN, JJ AF SATORIUS, EH MULLIGAN, JJ TI MINIMUM ENTROPY DECONVOLUTION AND BLIND EQUALIZATION SO ELECTRONICS LETTERS LA English DT Article DE DIGITAL COMMUNICATIONS; EQUALIZATION; CONVOLUTION ID SYSTEMS AB Relationships between minimum entropy deconvolution, developed primarily for geophysics applications, and blind equalisation are pointed out. It is seen that a large class of existing blind equalisation algorithms are directly related to the scale-invariant cost functions used in minimum entropy deconvolution. Thus the extensive analyses of these cost functions can be directly applied to blind equalisation, including the important asymptotic results of Donoho. C1 USA,CECOM SIGNALS WARFARE DIRECTORATE,AMSEL RD SW TRS,VINT HILL FARMS STN,WARRENTON,VA 22186. RP SATORIUS, EH (reprint author), JET PROP LAB,MS 238-420,4800 OAK GROVE DR,PASADENA,CA 91109, USA. NR 7 TC 9 Z9 9 U1 0 U2 1 PU IEE-INST ELEC ENG PI HERTFORD PA MICHAEL FARADAY HOUSE SIX HILLS WAY STEVENAGE, HERTFORD, ENGLAND SG1 2AY SN 0013-5194 J9 ELECTRON LETT JI Electron. Lett. PD JUL 30 PY 1992 VL 28 IS 16 BP 1534 EP 1535 DI 10.1049/el:19920974 PG 2 WC Engineering, Electrical & Electronic SC Engineering GA JJ037 UT WOS:A1992JJ03700037 ER PT J AU STOGSDILL, WR WITTWER, RF HENNESSEY, TC DOUGHERTY, PM AF STOGSDILL, WR WITTWER, RF HENNESSEY, TC DOUGHERTY, PM TI WATER-USE IN THINNED LOBLOLLY-PINE PLANTATIONS SO FOREST ECOLOGY AND MANAGEMENT LA English DT Article AB Soil moisture and throughfall were monitored for two growing seasons under three thinning intensities: basal areas of 7.8 m2 ha-1, 12.6 m2 ha-1 and 26.6 m2 ha-1 (unthinned control) in an 11- to 12-year-old loblolly pine (Pinus taeda L.) plantation. The first year after thinning soil water decreased at a rate of 0.8 mm day-1, 1.0 mm day-1 and 1.4 mm day-1, respectively, in the 7.8 m2 ha-1, 12.6 m2 ha-1, and 26.6 m2 ha-1 basal area plots between May and late August. The more rapid development of soil moisture deficits in the unthinned stand was owing to both greater soil moisture use and reduced throughfall. For the same time period in the second year, with below-normal rainfall, soil moisture deficits developed at a rate of 1.5, 1.5 and 1.7 mm day-1 for the two heavily thinned and the unthinned treatments. Estimated growing season soil water use rates were 4.4 mm day-1, 4.2 mm day-1, and 4.0 mm day-1, respectively for the 7.8 m2 ha-1, 12.6 m2 ha-1 and 26.6 m2 ha-1 basal area levels in Year 1. The second year after thinning water use rates for the same period were 2.7 mm day-1, 2.6 mm day-1, and 2.5 mm day-1, respectively. The results of this study suggest that the capacity to manage available water in loblolly pine stands by thinning is more a function of reduced interception loss and increased throughfall than reduced water use and is also weather dependent. Growing seasons with low rainfall or only one or two large rainfall events will not permit much opportunity to manage soil moisture. C1 OKLAHOMA STATE UNIV,DEPT FORESTRY,STILLWATER,OK 74078. USA,CORP ENGINEERS,ARKADELPHIA,AR 71923. US FOREST SERV,RES TRIANGLE PK,NC 27709. NR 20 TC 39 Z9 42 U1 1 U2 7 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-1127 J9 FOREST ECOL MANAG JI For. Ecol. Manage. PD JUL 30 PY 1992 VL 50 IS 3-4 BP 233 EP 245 DI 10.1016/0378-1127(92)90338-A PG 13 WC Forestry SC Forestry GA JJ914 UT WOS:A1992JJ91400004 ER PT J AU KUAN, CH TSUI, DC CHOI, KK AF KUAN, CH TSUI, DC CHOI, KK TI SUPERLATTICE BAND-STRUCTURE PROBED BY TUNNELING HOT-ELECTRON INJECTION SO APPLIED PHYSICS LETTERS LA English DT Article ID QUANTUM TRANSPORT; PHONON EMISSION; BARRIER; STATES AB Tunneling hot-electron injection is used to probe superlattice (SL) minibands and the effect of a magnetic field (B) on a 10-mu-m infrared (IR) detector. Within each miniband, the data agree with the transmission calculation including nonparabolicity, but outside the miniband, the data show that around 15% of electrons can pass through the SL due to impurity scattering. When B is applied, the injection energy of the hot electrons increases slightly. For the IR detector samples, a Gaussian hot-electron distribution gives a better fit to the data than the Lorentzian one, indicating that inhomogeneous broadening is significant in these devices. C1 USA,ELECTR TECHNOL & DEVICES LAB,FT MONMOUTH,NJ 07703. RP KUAN, CH (reprint author), PRINCETON UNIV,DEPT ELECT ENGN,PRINCETON,NJ 08544, USA. RI Choi, Kwong-Kit/K-9205-2013 NR 11 TC 11 Z9 11 U1 1 U2 1 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD JUL 27 PY 1992 VL 61 IS 4 BP 456 EP 458 DI 10.1063/1.107883 PG 3 WC Physics, Applied SC Physics GA JE821 UT WOS:A1992JE82100029 ER PT J AU SEAVER, M PEELE, JR MANUCCIA, TJ RUBEL, GO RITCHIE, G AF SEAVER, M PEELE, JR MANUCCIA, TJ RUBEL, GO RITCHIE, G TI EVAPORATION KINETICS OF VENTILATED WATERDROPS COATED WITH OCTADECANOL MONOLAYERS SO JOURNAL OF PHYSICAL CHEMISTRY LA English DT Article ID WIND-TUNNEL AB We have used remote thermometry and video microscopy to monitor simultaneously the temperature and size of evaporating waterdrops coated with monolayers of 1-octadecanol (stearyl alcohol). The experiments are conducted by acoustically levitating individual, 1-3-mm-diameter waterdrops in a 1.5 m/s nitrogen flow conditioned at 0, 35, and 64% relative humidity. We observe a continuous increase in monolayer resistivity as evaporation compresses the monolayer. The change in monolayer resistivity is independent of relative humidity. However, the rate of the resistivity increase is inversely proportional to the relative humidity. Remote drop temperature measurements show that the drop remains in thermal steady state with its surroundings during the monolayer phase change. We show that the additive Eu(EDTA), necessary for remote thermometry, accelerates the onset of the monolayer phase transition and reduces the final resistivity of the monolayer without effecting the monolayer during the phase change. We also discuss the appropriate use of accommodation coefficients and report them when possible. C1 USA,ARMAMENT MUNIT & CHEM COMMAND,CTR CHEM RES DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010. RIDER COLL,DEPT PHYS,LAWRENCEVILLE,NJ 08648. RP SEAVER, M (reprint author), USN,RES LAB,CODE 6540,WASHINGTON,DC 20375, USA. NR 23 TC 13 Z9 13 U1 0 U2 4 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0022-3654 J9 J PHYS CHEM-US JI J. Phys. Chem. PD JUL 23 PY 1992 VL 96 IS 15 BP 6389 EP 6394 DI 10.1021/j100194a053 PG 6 WC Chemistry, Physical SC Chemistry GA JF326 UT WOS:A1992JF32600053 ER PT J AU ROSENBERG, PS LEVY, ME BRUNDAGE, JF PETERSEN, LR KARON, JM FEARS, TR GARDNER, LI GAIL, MH GOEDERT, JJ BLATTNER, WA RYAN, CC VERMUND, SH BIGGAR, RJ AF ROSENBERG, PS LEVY, ME BRUNDAGE, JF PETERSEN, LR KARON, JM FEARS, TR GARDNER, LI GAIL, MH GOEDERT, JJ BLATTNER, WA RYAN, CC VERMUND, SH BIGGAR, RJ TI POPULATION-BASED MONITORING OF AN URBAN HIV AIDS EPIDEMIC - MAGNITUDE AND TRENDS IN THE DISTRICT-OF-COLUMBIA SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; SHORT-TERM PROJECTIONS; UNITED-STATES; SENTINEL HOSPITALS; INFECTION; PREVALENCE; SPREAD; SIZE AB Objective.-To assess the extent of the human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) epidemic in the District of Columbia and demonstrate an approach to monitoring HIV infection and projecting AIDS incidence at a community level. Design.-Backcalculation methods to reconstruct HIV incidence from AIDS incidence in subgroups. Results were compared with directly measured HIV seroprevalence in selected sentinel populations: childbearing women, civilian applicants for military service, and hospital patients admitted for conditions unrelated to HIV infection. Results.-Between the start of the epidemic in 1980 and January 1, 1991, one in 57 District of Columbia men aged 20 to 64 years was diagnosed with AIDS. Unlike the plateau projected for the nation, AIDS incidence for the District of Columbia was projected to increase by 34% between 1990 and 1994. Models of HIV infection incidence suggested two broad epidemic waves of approximately equal size. The first occurred in men who have sex with men and peaked during the period from 1982 through 1983. The second began in the mid-1980s in injecting drug users and heterosexuals. We estimated that among District of Columbia residents aged 20 to 64 years, 0.3% of white women, 2.9% of white men, 1.6% of black women, and 4.9% of black men were living with HIV infection as of January 1, 1991. These estimates are broadly consistent with survey data: among black childbearing women in their 20s, HIV prevalence doubled to 2% between the fall of 1989 and the spring of 1991; from military applicant data, we estimated that over 5% of black men born from 1951 through 1967 were HIV-positive; in the sentinel hospital, HIV prevalence rates among male patients aged 25 to 34 years were 11.3% in white men and 16.9% in black men. Conclusion.-Backcalculation and surveys yielded quantitatively consistent estimates of HIV prevalence. Many injecting drug users and heterosexuals in the District of Columbia were infected after January 1, 1986. Similar monitoring of the epidemic in other localities is needed to focus efforts to reduce the incidence of HIV transmission. C1 NCI,ENVIRONM EPIDEMIOL BRANCH,VIRAL EPIDEMIOL SECT,ROCKVILLE,MD 20892. WALTER REED ARMY MED CTR,DIV PREVENT MED,WASHINGTON,DC 20307. CTR DIS CONTROL,CTR INFECT DIS,DIV HIV AIDS,POPULAT STUDIES SECT,ATLANTA,GA 30333. CTR DIS CONTROL,CTR INFECT DIS,DIV HIV AIDS,STAT & DATA MANAGEMENT BRANCH,ATLANTA,GA 30333. DIST COLUMBIA COMMISS PUBL HLTH,AGCY HIV AIDS,WASHINGTON,DC. NIAID,DIV AIDS,VACCINE TRIALS EPIDEMIOL BRANCH,BETHESDA,MD 20892. DIST COLUMBIA COMMISS PUBL HLTH,PREVENT HLTH SERV ADM,WASHINGTON,DC. RP ROSENBERG, PS (reprint author), NCI,BIOSTAT BRANCH,EPIDEMIOL METHODS SECT,6130 EXECUT BLVD,EPN 403,ROCKVILLE,MD 20892, USA. OI Vermund, Sten/0000-0001-7289-8698 NR 45 TC 24 Z9 24 U1 1 U2 1 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD JUL 22 PY 1992 VL 268 IS 4 BP 495 EP 503 PG 9 WC Medicine, General & Internal SC General & Internal Medicine GA JD472 UT WOS:A1992JD47200024 PM 1619741 ER PT J AU ROSEN, DL GILLESPIE, JB AF ROSEN, DL GILLESPIE, JB TI FLUORESCENCE LIDAR DETECTION WITH SHOT NOISE AND SKY RADIANCE SO APPLIED OPTICS LA English DT Article DE LIDAR; FLUORESCENCE; RANK ANNIHILATION; FACTOR ANALYSIS; LASER-INDUCED FLUORESCENCE; DETECTION; ULTRAVIOLET ID QUANTITATIVE-ANALYSES; RANK ANNIHILATION AB Rank annihilation-factor analysis is potentially the best method of analyzing fluorescence lidar returns because of the following capability. Rank annihilation can recognize a fluorescence signal of a component that is hidden by a large fluorescence background without a spectrum of that background. Theoretical models were developed to analyze the effectiveness of rank annihilation-factor analysis in the interpretation of lidar returns. Interferents such as background fluorescence, photon-counting noise, sky radiance, and atmospheric extinction degraded the lidar-return spectra in numerical simulations. The rank annihilation-factor analysis detection algorithm was most severely biased by the combination of photon-counting noise and sky radiance. Rank annihilation calculations were also compared with calculations done by two other detection algorithms: finding peak wavelengths and the least-squares technique. Rank annihilation is better than both techniques. RP ROSEN, DL (reprint author), USA,ATMOSPHER SCI LAB,WHITE SANDS MISSILE RANGE,NM 88002, USA. NR 20 TC 4 Z9 4 U1 0 U2 4 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0003-6935 J9 APPL OPTICS JI Appl. Optics PD JUL 20 PY 1992 VL 31 IS 21 BP 4214 EP 4223 PG 10 WC Optics SC Optics GA JE407 UT WOS:A1992JE40700021 PM 20725405 ER PT J AU BEN-DAVID, A EMERY, SL GOTOFF, SW DAMICO, FM AF BEN-DAVID, A EMERY, SL GOTOFF, SW DAMICO, FM TI HIGH PULSE REPETITION FREQUENCY, MULTIPLE WAVELENGTH, PULSED CO2 LIDAR SYSTEM FOR ATMOSPHERIC TRANSMISSION AND TARGET REFLECTANCE MEASUREMENTS SO APPLIED OPTICS LA English DT Article DE CO2 LIDAR; DIAL; ATMOSPHERIC TRANSMISSION; TARGET REFLECTANCE MEASUREMENT ID DIFFERENTIAL ABSORPTION LIDAR; WATER-VAPOR; CO2-LASER WAVELENGTHS; DIAL MEASUREMENT; CARBON-DIOXIDE; TEA LASER; RANGE; CALIBRATION; SENSITIVITY; MINERALS AB A multiple wavelength, pulsed CO2 lidar system operating at a pulse repetition frequency of 200 Hz and permitting the random selection Of CO2 laser wavelengths for each laser pulse is presented. This system was employed to measure target reflectance and atmospheric transmission by using laser pulse bursts consisting of groups with as many as 16 different wavelengths at a repetition rate of 12 Hz. The wavelength tuning mechanism of the transversely excited atmospheric laser consists of a stationary grating and a flat mirror controlled by a galvanometer. Multiple wavelength, differential absorption lidar (DIAL) measurements reduce the effects of differential target reflectance and molecular absorption interference. Examples of multiwavelength DIAL detection for ammonia and water vapor show the dynamic interaction between these two trace gases. Target reflectance measurements for maple trees in winter and autumn are presented. C1 USA, CTR DEV & ENGN, ABERDEEN PROVING GROUND, MD 21010 USA. RP BEN-DAVID, A (reprint author), SCI & TECHNOL CORP, 2719 PULASKI HIGHWAY, UNIT 1, EDGEWOOD, MD 21040 USA. NR 39 TC 11 Z9 12 U1 0 U2 1 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA SN 1559-128X J9 APPL OPTICS JI Appl. Optics PD JUL 20 PY 1992 VL 31 IS 21 BP 4224 EP 4232 PG 9 WC Optics SC Optics GA JE407 UT WOS:A1992JE40700022 PM 20725406 ER PT J AU MARTIN, TW JOHNS, JP PUPA, LE AF MARTIN, TW JOHNS, JP PUPA, LE TI PHARMACOLOGICAL STRESS ECHOCARDIOGRAPHY - RESPONSE SO ANNALS OF INTERNAL MEDICINE LA English DT Letter C1 BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234. RP MARTIN, TW (reprint author), WILLIAM BEAUMONT ARMY MED CTR,EL PASO,TX 79920, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU AMER COLL PHYSICIANS PI PHILADELPHIA PA INDEPENDENCE MALL WEST 6TH AND RACE ST, PHILADELPHIA, PA 19106-1572 SN 0003-4819 J9 ANN INTERN MED JI Ann. Intern. Med. PD JUL 15 PY 1992 VL 117 IS 2 BP 168 EP 169 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA JD123 UT WOS:A1992JD12300015 ER PT J AU LAL, RB RUDOLPH, DL COLIGAN, JE BRODINE, SK ROBERTS, CR AF LAL, RB RUDOLPH, DL COLIGAN, JE BRODINE, SK ROBERTS, CR TI FAILURE TO DETECT EVIDENCE OF HUMAN T-LYMPHOTROPIC VIRUS (HTLV) TYPE-I AND TYPE-II IN BLOOD-DONORS WITH ISOLATED GAG ANTIBODIES TO HTLV-I/II SO BLOOD LA English DT Article ID MONOCLONAL-ANTIBODY; INFECTION; SEQUENCE; ANTIGEN; PROTEINS; HOMOLOGY; DEFINES; REGION C1 NIAID,BIOL RESOURCE BRANCH,BETHESDA,MD 20892. USN HOSP,HLTH RES CTR,SAN DIEGO,CA 92134. WALTER REED ARMY MED CTR,DEPT DIAGNOST RETROVIROL,WASHINGTON,DC 20307. RP LAL, RB (reprint author), CTR DIS CONTROL,NATL CTR INFECT DIS,DIV VIRAL & RICKETTSIAL DIS,ATLANTA,GA 30333, USA. NR 35 TC 58 Z9 59 U1 0 U2 2 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0006-4971 J9 BLOOD JI Blood PD JUL 15 PY 1992 VL 80 IS 2 BP 544 EP 550 PG 7 WC Hematology SC Hematology GA JD588 UT WOS:A1992JD58800033 PM 1627806 ER PT J AU WASCHER, RA LEE, MYT AF WASCHER, RA LEE, MYT TI RECURRENT CUTANEOUS LEIOMYOSARCOMA SO CANCER LA English DT Article DE SARCOMA; SUPERFICIAL LEIOMYOSARCOMA; CUTANEOUS LEIOMYOSARCOMA; SUBCUTANEOUS LEIOMYOSARCOMA ID SUBCUTANEOUS TISSUE; SKIN AB Background. Soft tissue sarcomas comprise approximately 0.7% of all malignant neoplasms. Superficial leiomyosarcoma, a rare malignant lesion, constitutes 4.0-6.5% of all soft tissue sarcomas, an overall incidence of approximately 0.04% among all cancers. Currently, less than 125 cumulative cases of cutaneous and subcutaneous leiomyosarcoma have been reported in the English literature. Methods. The authors report the case of a 70-year-old Japanese man with recurrent cutaneous leiomyosarcoma who was treated by wide local excision. A comprehensive literature survey is also presented. Results. The patient is free from recurrence 1 year after wide local excision of a second recurrence of cutaneous leiomyosarcoma. Moreover, superficial leiomyosarcoma can be subdivided into cutaneous leiomyosarcoma and subcutaneous leiomyosarcoma, based on histolopathologic and prognostic differences. Conclusions. The treatment of choice of superficial leiomyosarcoma is wide local excision. Cutaneous leiomyosarcoma is associated with local recurrence only, although subcutaneous leiomyosarcoma undergoes metastatic spread in 30-60% of cases, with a 30-40% mortality rate. RP WASCHER, RA (reprint author), TRIPLER ARMY MED CTR,DEPT SURG,GEN SURG SERV,HONOLULU,HI 96859, USA. NR 29 TC 19 Z9 21 U1 0 U2 1 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0008-543X J9 CANCER JI Cancer PD JUL 15 PY 1992 VL 70 IS 2 BP 490 EP 492 DI 10.1002/1097-0142(19920715)70:2<490::AID-CNCR2820700218>3.0.CO;2-F PG 3 WC Oncology SC Oncology GA JC673 UT WOS:A1992JC67300017 PM 1617597 ER PT J AU TRIRAWATANAPONG, T CHANDRAN, B PUTNAK, R PADMANABHAN, R AF TRIRAWATANAPONG, T CHANDRAN, B PUTNAK, R PADMANABHAN, R TI MAPPING OF A REGION OF DENGUE VIRUS TYPE-2 GLYCOPROTEIN REQUIRED FOR BINDING BY A NEUTRALIZING MONOCLONAL-ANTIBODY SO GENE LA English DT Article DE RECOMBINANT DNA; LAMBDA PL PROMOTER; EXPRESSION IN ESCHERICHIA-COLI; EPITOPE MAPPING; PCR; DELETION MUTAGENESIS; MAB; SYNTHETIC PEPTIDE ANTIGEN ID BORNE ENCEPHALITIS-VIRUS; HERPES-SIMPLEX VIRUS; PROTEIN ANTIGENIC DETERMINANTS; YELLOW-FEVER VIRUS; STRUCTURAL PROTEINS; NUCLEOTIDE-SEQUENCE; HEMAGGLUTINATION INHIBITION; SYNTHETIC PEPTIDES; ENVELOPE PROTEIN; FLAVIVIRUS AB Envelope glycoprotein E of flaviviruses is exposed at the surface of the virion, and is responsible for eliciting a neutralizing antibody (Ab) response, as well as protective immunity in the host. In this report, we describe a method for the fine mapping of a linear sequence of the E protein of dengue virus type-2 (DEN-2), recognized by a type-specific and neutralizing monoclonal Ab (mAb), 3H5. First, an Escherichia coli expression vector containing a heat-inducible lambda-P(L) promoter was used to synthesize several truncated, and near-full length E polypeptides. Reactivities of these polypeptides with polyclonal mouse hyperimmune sera, as well as the 3H5 mAb revealed the location of the 3H5-binding site to be within a region of 166 amino acids (aa) between aa 255 and 422. For fine mapping, a series of targeted deletions were made inframe within this region using the polymerase chain reaction (PCR). The hydrophilicity pattern of this region was used as a guide to systematically delete the regions encoding the various groups of surface aa residues within the context of a near-full-length E polypeptide by using PCR. The 3H5-binding site was thus precisely mapped to a region encoding 12 aa (between aa 386 and 397). A synthetic peptide containing this sequence was able to bind to the 3H5 mAb specifically, as shown by enzyme-linked immunosorbent assay. In addition, we show that rabbit Abs raised against the synthetic peptide of 12 aa were able to bind to the authentic E protein, and to neutralize DEN-2 virus in a plaque reduction assay. C1 UNIV KANSAS,MED CTR,DEPT BIOCHEM & MOLEC BIOL,39TH & RAINBOW BLVD,KANSAS CITY,KS 66103. UNIV KANSAS,MED CTR,DEPT MICROBIOL MOLEC GENET & IMMUNOL,KANSAS CITY,KS 66103. WALTER REED ARMY MED CTR,DEPT VIRUS DIS,WASHINGTON,DC 20307. NR 57 TC 57 Z9 57 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-1119 J9 GENE JI Gene PD JUL 15 PY 1992 VL 116 IS 2 BP 139 EP 150 DI 10.1016/0378-1119(92)90509-N PG 12 WC Genetics & Heredity SC Genetics & Heredity GA JF008 UT WOS:A1992JF00800003 PM 1634111 ER PT J AU ANDREAS, EL AF ANDREAS, EL TI SEA SPRAY AND THE TURBULENT AIR-SEA HEAT FLUXES SO JOURNAL OF GEOPHYSICAL RESEARCH-OCEANS LA English DT Article ID ATMOSPHERIC SURFACE-LAYER; SIZE DISTRIBUTIONS; AEROSOL PRODUCTION; RELATIVE-HUMIDITY; OCEAN; WHITECAPS; WATER; PARAMETERIZATION; COEFFICIENTS; EVAPORATION AB Heat and moisture carried by sea spray have long been suspected of contributing to the air-sea fluxes of sensible and latent heat. Using time scales that parameterize how long sea spray droplets reside in the air and how quickly they exchange heat and moisture with their environment, I estimate sea spray contributions to the air-sea heat fluxes. To make these estimates, I first develop a new sea spray generation function that predicts more realistic spume production than earlier models. Spray droplets with initial radii between 10 and 300-mu-m contribute most to the heat fluxes; the vast majority of these are spume droplets. The modeling not only demonstrates how spray droplets participate in the air-sea heat exchange but also confirms earlier predictions that the heat carried by sea spray (especially the latent heat) is an important component of the air-sea heat balance. In my examples, the maximum magnitude of the spray latent heat flux for a 20-m/s wind is 170 W/m2; the maximum spray sensible heat flux is 33 W/m2. For winds over 10 m/s, the spray latent heat flux is usually a substantial fraction of the interfacial (or turbulent) latent heat flux (estimated from the bulk-aerodynamic equations) and will thus confound measurements of the air-sea transfer coefficient for latent heat. RP USA, COLD REG RES & ENGN LAB, 72 LYME RD, HANOVER, NH 03755 USA. NR 76 TC 121 Z9 130 U1 1 U2 12 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA SN 2169-9275 EI 2169-9291 J9 J GEOPHYS RES-OCEANS JI J. Geophys. Res.-Oceans PD JUL 15 PY 1992 VL 97 IS C7 BP 11429 EP 11441 DI 10.1029/92JC00876 PG 13 WC Oceanography SC Oceanography GA JE564 UT WOS:A1992JE56400019 ER PT J AU CLARK, KD AF CLARK, KD TI DECOMPOSITION OF HESSENBERG DAE SYSTEMS TO STATE-SPACE FORM SO LINEAR ALGEBRA AND ITS APPLICATIONS LA English DT Article ID DIFFERENTIAL-ALGEBRAIC SYSTEMS; NUMERICAL-SOLUTION AB An algorithm is given for symbolically decoupling the solutions to a linear, time dependent differential-algebraic equation Ez' = A(t) z + f(t), z(t) is-an-element-of R(S), in Hessenberg form into state and algebraic components. The state variables are the solutions to an ordinary differential equation with initial conditions restricted to a subspace of R(S), while the algebraic components are linear functions of the state variables involving derivatives of the coefficients and input functions up to order r - 1, where r is the index of the system. This decomposition provides closed form solutions to linear Hessenberg DAEs in terms of the fundamental solutions of the state variable system. The implications of the algorithm for computing consistent initial conditions, for certain singular optimal control problems, and for numerical solutions are briefly discussed. RP CLARK, KD (reprint author), USA,RES OFF,DIV MATH & COMP SCI,RES TRIANGLE PK,NC 27709, USA. NR 17 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0024-3795 J9 LINEAR ALGEBRA APPL JI Linear Alg. Appl. PD JUL 15 PY 1992 VL 172 BP 33 EP 55 DI 10.1016/0024-3795(92)90017-5 PG 23 WC Mathematics, Applied; Mathematics SC Mathematics GA JB660 UT WOS:A1992JB66000003 ER PT J AU WARREN, WL KANICKI, J RONG, FC POINDEXTER, EH MCWHORTER, PJ AF WARREN, WL KANICKI, J RONG, FC POINDEXTER, EH MCWHORTER, PJ TI CHARGE TRAPPING CENTERS IN N-RICH SILICON-NITRIDE THIN-FILMS SO APPLIED PHYSICS LETTERS LA English DT Article ID CORRELATION-ENERGY; MODEL AB We have examined the behavior of the Si dangling-bond center in regard to charge trapping in N-rich amorphous hydrogenated silicon nitride thin films. The effects of multiple electron and hole injections were monitored by electron paramagnetic resonance. These results continue to support a model in which the Si dangling bond is a negative U defect in N-rich nitrides, and that a change in charge state of pre-existing diamagnetic positively and negatively charged sites is responsible for the memory properties of silicon nitride thin films. C1 IBM CORP,THOMAS J WATSON RES CTR,YORKTOWN HTS,NY 10598. USA,ELECTR TECHNOL & DEVICES LAB,FT MONMOUTH,NJ 07703. RP WARREN, WL (reprint author), SANDIA NATL LABS,ALBUQUERQUE,NM 87185, USA. RI Kanicki, Jerzy/E-2753-2016 OI Kanicki, Jerzy/0000-0002-3649-8360 NR 14 TC 27 Z9 28 U1 0 U2 4 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD JUL 13 PY 1992 VL 61 IS 2 BP 216 EP 218 DI 10.1063/1.108222 PG 3 WC Physics, Applied SC Physics GA JD352 UT WOS:A1992JD35200033 ER PT J AU DAVE, PR BRACUTI, A AXENROD, T LIANG, BM AF DAVE, PR BRACUTI, A AXENROD, T LIANG, BM TI THE SYNTHESIS AND COMPLETE H-1 NMR AND C-13 NMR SPECTRAL ASSIGNMENT OF 2,2,4,4,6,6-HEXANITROADAMANTANE AND ITS PRECURSOR NITROKETONES BY 2D NMR-SPECTROSCOPY SO TETRAHEDRON LA English DT Article AB The synthesis of 2,2,4,4,6,6-hexanitroadamantane from the precursors, 4,4,6,6-tetranitroadamantan-2-one and 4,4-dinitroadamantane-2,6-dione is reported. The complete H-1 and C-13 NMR assignment of these compounds by 2D C-13-H-1 shift correlated spectra, H-1-H-1 COSY spectra and H-1-H-1 NOESY spectra is described. C1 USA,CTR DEV & ENGN,PICATINNY ARSENAL,NJ 07806. CUNY CITY COLL,DEPT CHEM,NEW YORK,NY 10031. RP DAVE, PR (reprint author), ARDEC,GEO CTR INC,762 ROUTE 15 S,LAKE HOPATCONG,NJ 07849, USA. NR 10 TC 6 Z9 7 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0040-4020 J9 TETRAHEDRON JI Tetrahedron PD JUL 10 PY 1992 VL 48 IS 28 BP 5839 EP 5846 DI 10.1016/S0040-4020(01)90175-9 PG 8 WC Chemistry, Organic SC Chemistry GA JD931 UT WOS:A1992JD93100005 ER PT J AU LUX, DP AF LUX, DP TI SOCIAL AND ECONOMIC-FACTORS IN PATIENTS WITH CORONARY-DISEASE SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Letter RP LUX, DP (reprint author), WOMACK ARMY MED CTR, FT BRAGG, NC 28307 USA. NR 3 TC 0 Z9 0 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 0098-7484 EI 1538-3598 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD JUL 8 PY 1992 VL 268 IS 2 BP 196 EP 197 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA JB279 UT WOS:A1992JB27900012 PM 1608131 ER PT J AU HAN, WY LU, Y LEE, HS COLE, MW SCHAUER, SN MOERKIRK, RP JONES, KA YANG, LW AF HAN, WY LU, Y LEE, HS COLE, MW SCHAUER, SN MOERKIRK, RP JONES, KA YANG, LW TI ANNEALING EFFECTS ON HEAVILY CARBON-DOPED GAAS SO APPLIED PHYSICS LETTERS LA English DT Article ID MOLECULAR-BEAM EPITAXY; HYDROGEN AB The hole concentrations and lattice mismatch with the GaAs substrate of heavily carbon-doped epilayers (4.7x10(19) and 9.8x10(19) cm-3) were increased and the mobilities were decreased as compared with the as-grown samples by rapid thermal annealing silicon nitride capped samples at temperatures from 500 to 900-degrees-C. However, for the more heavily doped sample, the hole concentration, mobility, and lattice mismatch decreased with increasing annealing temperature for annealing temperatures higher than 700-degrees-C, but the hole concentration and lattice mismatch were still larger than those of the as-grown samples. Secondary ion mass spectroscopy results showed that annealing produced no change in the C concentration or distribution, but the hydrogen concentration decreased. Cross-sectional transmission electron microscopy indicated that no mismatch dislocations formed at the interface. C1 USA,ELECTR TECHNOL & DEVICE LAB,FT MONMOUTH,NJ 07703. FORD MICROELECTR INC,COLORADO SPRINGS,CO 80921. RP HAN, WY (reprint author), RUTGERS STATE UNIV,DEPT ELECT & COMP ENGN,PISCATAWAY,NJ 08855, USA. RI Schaff, William/B-5839-2009 NR 17 TC 29 Z9 29 U1 0 U2 1 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD JUL 6 PY 1992 VL 61 IS 1 BP 87 EP 89 DI 10.1063/1.107622 PG 3 WC Physics, Applied SC Physics GA JB747 UT WOS:A1992JB74700030 ER PT J AU CHATTERJEE, S JETT, M AF CHATTERJEE, S JETT, M TI GLYCOSPHINGOLIPIDS - THE PUTATIVE RECEPTOR FOR STAPHYLOCOCCUS-AUREUS ENTEROTOXIN-B IN HUMAN KIDNEY PROXIMAL TUBULAR CELLS SO MOLECULAR AND CELLULAR BIOCHEMISTRY LA English DT Article DE GLYCOSPHINGOLIPIDS; KIDNEY PROXIMAL TUBULAR CELLS; STAPHYLOCOCCAL ENTEROTOXIN-A; ENTEROTOXIN-B; TOXIC SHOCK SYNDROME TOXIN ID CERAMIDE; BINDING; VIRUSES AB We have investigated the binding of I-125-staphylococcal enterotoxin-B (SEB) in cultured human proximal tubular cells. We found that the binding of I-125-SEB to PT cells was time and concentration dependent and competitively inhibited by antibody against SEB. Preincubation of cells with trypsin and neuraminidase or with fetuin did not significantly impair the binding of I-125-SEB to such cells. In contrast, treatment with endoglycoceramidase completely inhibited the binding of I-125-SEB to cells. Neutral glycosphingolipids exerted a concentration-dependent inhibition of I-125-SEB binding to such cells, maximum inhibition (96% compared to control) occurred upon incubation of PT cells with neutral glycosphingolipids. Taken together, our studies indicate that SEB specifically binds to a neutral glycosphingolipid in PT cells. In contrast, staphylococcal enterotoxin-A and toxic shock toxin (TST-1) are bound to a protein in such cells. C1 WALTER REED ARMY MED CTR,DEPT PATHOL,WASHINGTON,DC 20307. RP CHATTERJEE, S (reprint author), JOHNS HOPKINS UNIV,SCH MED,DEPT PEDIAT,ATHEROSCLEROSIS UNIT,CMSC 604,600 N WOLFE ST,BALTIMORE,MD 21205, USA. FU NIDDK NIH HHS [R0-1-DK-31722] NR 22 TC 22 Z9 23 U1 0 U2 0 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 0300-8177 J9 MOL CELL BIOCHEM JI Mol. Cell. Biochem. PD JUL 6 PY 1992 VL 113 IS 1 BP 25 EP 31 PG 7 WC Cell Biology SC Cell Biology GA JE196 UT WOS:A1992JE19600003 PM 1322493 ER PT J AU AKKARA, JA GREENBERGER, M KAPLAN, DL AF AKKARA, JA GREENBERGER, M KAPLAN, DL TI NEW ANALYTICAL METHODS FOR QUANTITATION OF 4 FUNGICIDES BY GAS AND HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY SO JOURNAL OF CHROMATOGRAPHY LA English DT Article AB New analytical methods were developed for the quantitation of para-nitrophenol, 2,2'-methylenebis(4-chlorophenol), salicylanilide and copper 8-quinolinolate, by high-performance liquid and ps chromatography. The first three were extracted for 4-8 h from leather, cotton and felt samples, respectively, by acetonitrile in a Soxhlet, and then quantitated by high-performance liquid chromatography using a C18 reversed-phase column and a UV detector. Copper 8-quinolinolate was extracted by dilute sulfuric acid and the acid extract was treated with a chelating agent to release 8-hydroxyquinoline. 8-Hydroxyquinoline was in tum extracted and quantitated by gas chromatography with a flame ionization detector. RP AKKARA, JA (reprint author), USA,NATICK RES DEV & ENGN CTR,DIV BIOTECHNOL,BOX 20,NATICK,MA 01760, USA. NR 7 TC 1 Z9 1 U1 2 U2 5 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0021-9673 J9 J CHROMATOGR PD JUL 3 PY 1992 VL 604 IS 2 BP 247 EP 253 DI 10.1016/0021-9673(92)85135-G PG 7 WC Chemistry, Analytical SC Chemistry GA JE248 UT WOS:A1992JE24800009 ER PT J AU PEPI, M CHAMPAGNE, V AF PEPI, M CHAMPAGNE, V TI STRESS-CORROSION CRACKING OF AN ALLOY-STEEL SO ADVANCED MATERIALS & PROCESSES LA English DT Article RP PEPI, M (reprint author), USA,MAT TECHNOL LAB,MAT ANAL GRP,WATERTOWN,MA 02172, USA. NR 0 TC 1 Z9 1 U1 0 U2 1 PU ASM INTERNATIONAL PI MATERIALS PARK PA SUBSCRIPTIONS SPECIALIST CUSTOMER SERVICE, MATERIALS PARK, OH 44073-0002 SN 0026-0665 J9 ADV MATER PROCESS JI Adv. Mater. Process. PD JUL PY 1992 VL 142 IS 1 BP 47 EP 47 PG 1 WC Materials Science, Multidisciplinary SC Materials Science GA JB020 UT WOS:A1992JB02000006 ER PT J AU GOLDMAN, DP ARTENSTEIN, AW BOLAN, CD AF GOLDMAN, DP ARTENSTEIN, AW BOLAN, CD TI HUMAN EHRLICHIOSIS - A NEWLY RECOGNIZED TICK-BORNE DISEASE SO AMERICAN FAMILY PHYSICIAN LA English DT Article AB Human ehrlichiosis was first described in the United States in 1986. Since then, more than 215 cases have been reported, including some fatalities. Ehrlichia species belong to the same family as the organism that causes Rocky Mountain spotted fever. Human ehrlichiosis occurs most frequently in the southern mid-Atlantic and south-central states, during spring and summer months. The clinical presentation is similar to that seen in Rocky Mountain spotted fever although, with ehrlichiosis, leukopenia is more of ten found and skin rash is less often noted. Definitive diagnosis is based on acute and convalescent serum antibody titers. Ehrlichiosis cannot reliably be distinguished from other common febrile illnesses on the basis of clinical, epidemiologic or laboratory features. Therapy must be initiated empirically in suspected cases. Both ehrlichiosis and Rocky Mountain spotted fever respond well to tetracycline and chloramphenicol, but not to penicillins or cephalosporins. RP GOLDMAN, DP (reprint author), DWIGHT D EISENHOWER ARMY MED CTR,TROOP MED CLIN 4,DEPT FAMILY PRACTICE,FT GORDON,GA 30905, USA. NR 0 TC 6 Z9 6 U1 0 U2 0 PU AMER ACAD FAMILY PHYSICIANS PI KANSAS CITY PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 SN 0002-838X J9 AM FAM PHYSICIAN JI Am. Fam. Physician PD JUL PY 1992 VL 46 IS 1 BP 199 EP 208 PG 10 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA JD743 UT WOS:A1992JD74300019 PM 1621632 ER PT J AU HORAM, WJ ROSCELLI, JD AF HORAM, WJ ROSCELLI, JD TI ESTABLISHING STANDARDS OF ORTHOSTATIC MEASUREMENTS IN NORMOVOLEMIC ADOLESCENTS SO AMERICAN JOURNAL OF DISEASES OF CHILDREN LA English DT Article ID CHILDREN AB Objective.-To determine normal orthostatic heart rate and blood pressure changes in healthy adolescents. Design.-Survey. Setting.-General adolescent clinic at a military teaching medical center in Honolulu, Hawaii. Participants.-One hundred healthy normovolemic patients aged 12 to 19 years representing a cross section of individuals from a diverse military population during a 5-month study period. Selection Procedure.-Convenience sample. Interventions.- None. Measurements/Main Results. - The mean (+/-2 SDs) orthostatic heart rate change in beats per minute was 21.5+/-21.2, with a range of 50 to -3 beats per minute. The mean (+/-2 SDs) systolic blood pressure change was -0.9+/-15.7 mm H& with a range of 19 to -17 mm Hg. Orthostatic measurements in a normal adolescent population may result in a heart rate increase of 40 to 50 beats per minute and a systolic blood pressure decrease of 15 mm Hg. There were no significant differences between individuals with respect to age, race, sex, and body habitus. Conclusions.-Healthy adolescents display wide variation in orthostatic measurements that exceed previously accepted standards. Further study is required to determine if sensitivity and specificity values exist for orthostatic measurements that can identify individuals with intravascular volume depletion. C1 TRIPLER ARMY MED CTR,DEPT PEDIAT,HONOLULU,HI 96859. NR 29 TC 6 Z9 6 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0002-922X J9 AM J DIS CHILD JI Am. J. Dis. Child. PD JUL PY 1992 VL 146 IS 7 BP 848 EP 851 PG 4 WC Pediatrics SC Pediatrics GA JC525 UT WOS:A1992JC52500025 PM 1496957 ER PT J AU MORRIS, JT KELLY, JW AF MORRIS, JT KELLY, JW TI EFFECTIVE TREATMENT OF CEREBRAL TOXOPLASMOSIS WITH DOXYCYCLINE SO AMERICAN JOURNAL OF MEDICINE LA English DT Note ID NERVOUS-SYSTEM TOXOPLASMOSIS; ENCEPHALITIS RP MORRIS, JT (reprint author), BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234, USA. NR 8 TC 5 Z9 5 U1 0 U2 0 PU EXCERPTA MEDICA INC PI NEW YORK PA 245 WEST 17TH STREET, NEW YORK, NY 10011 SN 0002-9343 J9 AM J MED JI Am. J. Med. PD JUL PY 1992 VL 93 IS 1 BP 107 EP 108 DI 10.1016/0002-9343(92)90692-5 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA JC655 UT WOS:A1992JC65500022 PM 1626560 ER PT J AU FULLERTON, CS MCCARROLL, JE URSANO, RJ WRIGHT, KM AF FULLERTON, CS MCCARROLL, JE URSANO, RJ WRIGHT, KM TI PSYCHOLOGICAL RESPONSES OF RESCUE WORKERS - FIRE FIGHTERS AND TRAUMA SO AMERICAN JOURNAL OF ORTHOPSYCHIATRY LA English DT Article ID SOCIAL SUPPORT; NATURAL DISASTER; STRESS RESEARCH; MORBIDITY; IMPACT; HEALTH; NEED AB The psychological responses of two groups of fire fighters were examined following the performance of rescue work. Four types of responses were reported: identification with the victims, feelings of helplessness and guilt, fear of the unknown, and physiological reactions. Stress was found to be mediated by availability of social support, type of leadership, level of training, and use of rituals. Implications of these findings for preventive intervention measures are discussed. C1 WALTER REED ARMY MED CTR,DEPT MIL PSYCHIAT,WASHINGTON,DC 20307. RP FULLERTON, CS (reprint author), UNIFORMED SERV UNIV HLTH SCI,F EDWARD HEBERT SCH MED,DEPT PSYCHIAT,4301 JONES BRIDGE RD,BETHESDA,MD 20814, USA. NR 37 TC 108 Z9 109 U1 1 U2 11 PU AMER ORTHOPSYCHIATRIC ASSN PI NEW YORK PA 19 W 44TH ST, NEW YORK, NY 10036 SN 0002-9432 J9 AM J ORTHOPSYCHIAT JI Am. J. Orthopsychiatr. PD JUL PY 1992 VL 62 IS 3 BP 371 EP 378 DI 10.1037/h0079363 PG 8 WC Psychiatry; Social Work SC Psychiatry; Social Work GA JJ462 UT WOS:A1992JJ46200008 PM 1497102 ER PT J AU KIANG, JG KOENIG, ML SMALLRIDGE, RC AF KIANG, JG KOENIG, ML SMALLRIDGE, RC TI HEAT-SHOCK INCREASES CYTOSOLIC FREE CA2+ CONCENTRATION VIA NA+-CA2+ EXCHANGE IN HUMAN EPIDERMOID-A-431 CELLS SO AMERICAN JOURNAL OF PHYSIOLOGY LA English DT Article ID PLASMA-MEMBRANE; A-431 CELLS; FREE CA-2+; INOSITOL TRISPHOSPHATE; NA+/CA-2+ EXCHANGE; GROWTH-FACTOR; A431 CELLS; CALCIUM; PROTEIN; TRANSPORT AB This study characterized cytosolic free Ca2+ concentration ([Ca2+]i) in normal and thermally injured human epidermoid A 431 cells. The resting [Ca2+]i in normal cells at 37-degrees-C was 87 +/- 5 nM (n = 105). When cells were subjected to hyperthermia (40-50-degrees-C), [Ca2+]i increased in a temperature- and time-dependent manner. The maximal increase in cells exposed to 45-degrees-C was observed at 20 min; [Ca2+] i returned to normal within 1 h. The heat-induced [Ca2+]i increase depended on the presence of external Ca2+. La3+ and Cd2+ but not Co2+, verapamil, or nifedipine attenuated the heat-induced [Ca2+]i increase. TMB-8 partially blocked the increase in [Ca2+]i but pertussis toxin and cholera toxin pretreatment did not. The magnitude of the heat-induced [Ca2+]i increase or Ca-45(2+) uptake depended on the presence of extracellular Na+. Heat treatment reduced the apparent Michaelis constant for external Ca2+ from 490 +/- 91 to 210 +/- 60-mu-M, whereas the maximal velocity remained the same. The intracellular Na+ concentration decreased 62.5% after heating. The heat-induced [Ca2+]i increase was completely blocked by amiloride (5-mu-M) and 5'-(N,N-dimethyl)-amiloride (1-mu-M). These results suggest heat activates the Na+-Ca2+ exchange system so as to increase [Ca2+]i and reduce [Na+]i. C1 WALTER REED ARMY MED CTR,DEPT MED NEUROSCI,DIV NEUROPSYCHIAT,WASHINGTON,DC 20307. RP KIANG, JG (reprint author), WALTER REED ARMY MED CTR,DEPT CLIN PHYSIOL,DIV MED,WASHINGTON,DC 20307, USA. NR 57 TC 51 Z9 52 U1 0 U2 0 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0002-9513 J9 AM J PHYSIOL JI Am. J. Physiol. PD JUL PY 1992 VL 263 IS 1 BP C30 EP C38 PN 1 PG 9 WC Physiology SC Physiology GA JF319 UT WOS:A1992JF31900004 PM 1636682 ER PT J AU CHILDS, JE GLASS, GE KORCH, GW KSIAZEK, TG LEDUC, JW AF CHILDS, JE GLASS, GE KORCH, GW KSIAZEK, TG LEDUC, JW TI LYMPHOCYTIC CHORIOMENINGITIS VIRUS-INFECTION AND HOUSE MOUSE (MUS-MUSCULUS) DISTRIBUTION IN URBAN BALTIMORE SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID SMALL MAMMAL COMMUNITIES; POPULATION; MARYLAND AB Four hundred eighty house mice (Mus musculus) were trapped primarily from urban sites in Baltimore, Maryland from 1984 to 1989 and tested for antibody to lymphocytic choriomeningitis virus (LCMV). The majority of mice (95%) were trapped in residences at two city locations (n = 260), or in an urban park (n = 196); five additional sites were sampled. Overall, 9.0% of the mice were LCMV antibody positive and infected animals were obtained from six of eight sites, including all three of the primary city sites, where the prevalence varied significantly (3.9-13.4%). The location with the highest prevalence was an inner city residential site where positive mice were found significantly clustered within blocks and households. In this location, LCMV antibody prevalence was also significantly correlated with estimates of mouse density within individual blocks. The focal nature of LCMV infection in house mice may result from contact or vertical transmission of virus in conjunction with the highly structured social system of mice, which promotes inbreeding and limited dispersal. C1 USA,MED RES INST INFECT DIS,DIV VIROL,FREDERICK,MD 21701. USA,MED RES INST INFECT DIS,DIV DIS ASSESSMENT,FREDERICK,MD 21701. RP CHILDS, JE (reprint author), JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,DEPT IMMUNOL & INFECT DIS,615 N WOLFE ST,BALTIMORE,MD 21205, USA. RI Childs, James/B-4002-2012 NR 40 TC 68 Z9 70 U1 1 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JUL PY 1992 VL 47 IS 1 BP 27 EP 34 PG 8 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA JF669 UT WOS:A1992JF66900006 PM 1636880 ER PT J AU BEIER, JC COPELAND, RS MTALIB, R VAUGHAN, JA AF BEIER, JC COPELAND, RS MTALIB, R VAUGHAN, JA TI OOKINETE RATES IN AFROTROPICAL ANOPHELINE MOSQUITOS AS A MEASURE OF HUMAN MALARIA INFECTIOUSNESS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID PAPUA-NEW-GUINEA; VECTORIAL CAPACITY; WESTERN KENYA; INFECTIVITY; CULICIDAE; DIPTERA; ELISA; IDENTIFICATION; TRANSMISSION; SPOROZOITE AB Anopheles gambiae s.l. and An.funestus were sampled for Plasmodium spp. ookinetes in two P. falciparum-endemic sites in western Kenya. Since the ookinete is a transitional stage of short duration, occurring after fertilization and before oocyst development, only females in the half-gravid and gravid stages of blood digestion were examined. Preparations of homogenized midguts were spotted onto microslides and examined microscopically after staining with Giemsa. Overall, ookinetes were detected in 4.4% of 1,079 anophelines examined over an eight-month period. Anopheles funestus had higher ookinete rates than An. gambiae s.l., and ookinete rates were higher in half-gravid than in gravid An. gambiae s.l. Geometric mean numbers of ookinetes per infected female were less than five for each species at the two sites, and the maximum number observed was only 12. The low frequencies and numbers of ookinetes were sufficient to produce sporozoite rates of 4-18% in the vector populations. The intense transmission of P. falciparum in these two sites is maintained by anthropophilic vectors where only one in 23 blood meals initiates an infection of generally less than five ookinetes. Relationships between human malaria infectiousness and vector infectivity are dependent upon the high efficiency of the developmental transition from the ookinete to the subsequent oocyst and sporozoite stages. C1 KENYA GOVT MED RES CTR,NAIROBI,KENYA. USA,MED RES UNIT,APO,NEW YORK,NY 09675. RP BEIER, JC (reprint author), JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,DEPT IMMUNOL & INFECT DIS,615 N WOLFE ST,BALTIMORE,MD 21205, USA. FU NIAID NIH HHS [AI-29000] NR 26 TC 24 Z9 24 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JUL PY 1992 VL 47 IS 1 BP 41 EP 46 PG 6 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA JF669 UT WOS:A1992JF66900008 PM 1636882 ER PT J AU SANCHEZ, JL DINIEGA, BM SMALL, JW MILLER, RN ANDUJAR, JM WEINA, PJ LAWYER, PG BALLOU, WR LOVELACE, JK AF SANCHEZ, JL DINIEGA, BM SMALL, JW MILLER, RN ANDUJAR, JM WEINA, PJ LAWYER, PG BALLOU, WR LOVELACE, JK TI EPIDEMIOLOGIC INVESTIGATION OF AN OUTBREAK OF CUTANEOUS LEISHMANIASIS IN A DEFINED GEOGRAPHIC FOCUS OF TRANSMISSION SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID DIAGNOSIS AB An outbreak of cutaneous leishmaniasis occurred in a unit of 608 Puerto Rican national guardsmen conducting jungle warfare training in the Panama Canal Area in July 1984. An epidemiologic investigation of reported nonhealing, ulcerating skin lesions was conducted among 540 (89%) unit members in November and December 1984. Fifteen (88%) of 17 individuals with chronic, ulcerating skin lesions were confirmed as cases of cutaneous leishmaniasis by culture or histopathology. Twelve cases yielded positive Leishmania cultures, identified as L. braziliensis panamensis by cellulose acetate electrophoresis. Evaluation of different diagnostic techniques revealed that direct examination of tissues by Giemsa-stained histological examination was the most sensitive test (87% sensitivity), with an indirect immunofluorescent antibody test being rather insensitive (67%). All but one of the confirmed cases operated in small units that trained and slept overnight at a mortar firing site for a period of three days, yielding a site-specific attack rate of 22% (14 of 64). This contrasted with a much lower attack rate of 0.2% (1 of 476), experienced by unit members who trained at other locations during the same time frame (P < 0.001). The median incubation period calculated from day of arrival at the mortar firing site was 17 days (range 2-78) for the 15 confirmed cases. Available personal protection methods, such as the use of insect repellents, were not appropriately implemented by unit personnel and thus, were not found to effectively protect against Leishmania infection. This is the largest reported outbreak of cutaneous leishmaniasis in military personnel associated with a single geographic focus of infection and contrasts with the usual sporadic disease experience in Panama. C1 WALTER REED ARMY MED CTR,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DIV COMMUNICABLE DIS & IMMUNOL,WASHINGTON,DC 20307. USA,ACAD HLTH SCI,DIV PREVENT MED,FT SAM HOUSTON,TX 78234. WORKMED OCCUPAT HLTH NETWORK,TULSA,OK. RP SANCHEZ, JL (reprint author), WALTER REED ARMY MED CTR,DEPT FIELD STUDIES,DIV PREVENT MED,WASHINGTON,DC 20307, USA. NR 26 TC 27 Z9 27 U1 0 U2 5 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JUL PY 1992 VL 47 IS 1 BP 47 EP 54 PG 8 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA JF669 UT WOS:A1992JF66900009 PM 1636883 ER PT J AU TURELL, MJ MALINOSKI, FJ AF TURELL, MJ MALINOSKI, FJ TI LIMITED POTENTIAL FOR MOSQUITO TRANSMISSION OF A LIVE, ATTENUATED CHIKUNGUNYA VIRUS-VACCINE SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID VALLEY FEVER VIRUS; CULEX-PIPIENS; SUSCEPTIBILITY; INFECTION AB Studies were conducted to determine the potential for transmission of a live, attenuated chikungunya (CHIK) virus vaccine by orally exposed or virus-inoculated mosquitoes. The vaccine (CHIK 181/clone 25) replicated in and was transmitted by female Aedes albopictus and Ae. aegypti after intrathoracic inoculation. Mosquitoes also became infected with the vaccine after ingesting virus from either a blood-soaked cotton pledget or a viremic monkey. However, because of the low viremias produced in inoculated humans, it is unlikely that mosquitoes would become infected by feeding on a person inoculated with the live, attenuated CHIK vaccine. Although the vaccine was transmitted by mosquitoes after intrathoracic inoculation, there was no evidence of reversion to a virulent phenotype. C1 USA,MED RES INST INFECT DIS,DEPT ARBOVIRAL ENTOMOL,DIV VIROL,FREDERICK,MD 21702. NR 15 TC 20 Z9 21 U1 1 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JUL PY 1992 VL 47 IS 1 BP 98 EP 103 PG 6 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA JF669 UT WOS:A1992JF66900016 PM 1322072 ER PT J AU WATT, G LOESUTTIVIBOOL, L SHANKS, GD BOUDREAU, EF BROWN, AE PAVANAND, K WEBSTER, HK WECHGRITAYA, S AF WATT, G LOESUTTIVIBOOL, L SHANKS, GD BOUDREAU, EF BROWN, AE PAVANAND, K WEBSTER, HK WECHGRITAYA, S TI QUININE WITH TETRACYCLINE FOR THE TREATMENT OF DRUG-RESISTANT FALCIPARUM-MALARIA IN THAILAND SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article AB Reports of deteriorating quinine efficacy prompted us to investigate the ability of quinine-tetracycline to clear parasites and fever from patients with multiple drug-resistant Plasmodium falciparum infections. Past and present treatment results were compared at two study sites along the Thai-Cambodian border. In northeastern Thailand, quinine-tetracycline cleared parasites more quickly in 1990 than in 1987 (mean 3.4 and 4.0 days, respectively; P = 0.006). In southeastern Thailand, there were no significant differences between 1990 (n = 26) and 1981-1983 (n = 42) in the time taken to clear either parasites (median 96 and 93 hr, respectively; P = 0.35) or fever (mean 74 and 66 hr, respectively; P = 0.30). In vitro drug sensitivity testing revealed a two-fold decrease in susceptibility to quinine between 1983 and 1990 in isolates from the southeastern Thai-Cambodian border (mean inhibitory concentration 166 ng/ml and 320 ng/ml, respectively; P < 0.001). We conclude that oral quinine-tetracycline continues to reliably clear parasites and fever from falciparum malaria patients infected in eastern Thailand. Periodic re-evaluations are warranted, however, since the decrease in in vitro susceptibility to quinine may be followed by an in vivo decay in the treatment response. C1 ROYAL THAI ARMY HOSP,ARANYAPRATHET,THAILAND. RP WATT, G (reprint author), ARMED FORCES RES INST MED SCI,BANGKOK,THAILAND. RI Shanks, George Dennis/F-4056-2014 OI Shanks, George Dennis/0000-0001-5763-8660 NR 12 TC 43 Z9 47 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JUL PY 1992 VL 47 IS 1 BP 108 EP 111 PG 4 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA JF669 UT WOS:A1992JF66900018 PM 1636876 ER PT J AU WONGSRICHANALAI, C WEBSTER, HK WIMONWATTRAWATEE, T SOOKTO, P CHUANAK, N THIMASARN, K WERNSDORFER, WH AF WONGSRICHANALAI, C WEBSTER, HK WIMONWATTRAWATEE, T SOOKTO, P CHUANAK, N THIMASARN, K WERNSDORFER, WH TI EMERGENCE OF MULTIDRUG-RESISTANT PLASMODIUM-FALCIPARUM IN THAILAND - INVITRO TRACKING SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID MEFLOQUINE; MALARIA; SUSCEPTIBILITY; SENSITIVITY AB Mefloquine was introduced into Thailand in 1985 for the treatment of Plasmodium falciparum infection. Recently, clinical failure of mefloquine was observed in southeastern Thailand, where an epidemic of falciparum malaria occurred. Beginning in 1984 and continuing until 1989, in vitro monitoring of P. falciparum isolates from Borai, a border district in the southeastern part of the country, showed a progressive decrease in mefloquine sensitivity until 1989; in 1990, the degree and prevalence of resistance accelerated. A similar pattern of resistance was observed for halofantrine, an antimalarial drug not yet commercially available in Thailand. In vitro sensitivity patterns of mefloquine and halofantrine elsewhere in the country remained relatively unchanged. These observations suggest a serious deterioration in available drugs for the treatment of falciparum malaria in southeastern Thailand that is predicted to spread throughout the country and Southeast Asia. C1 MINIST PUBL HLTH,MALARIA DIV,BANGKOK,THAILAND. UNIV VIENNA,INST SPECIF PROPHYLAXIS & TROP MED,A-1010 VIENNA,AUSTRIA. RP WONGSRICHANALAI, C (reprint author), ARMED FORCES RES INST MED SCI,DEPT IMMUNOL & BIOCHEM,315-6 RAJVITHI RD,BANGKOK 10400,THAILAND. NR 15 TC 43 Z9 44 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JUL PY 1992 VL 47 IS 1 BP 112 EP 116 PG 5 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA JF669 UT WOS:A1992JF66900019 PM 1636877 ER PT J AU GROGL, M THOMASON, TN FRANKE, ED AF GROGL, M THOMASON, TN FRANKE, ED TI DRUG-RESISTANCE IN LEISHMANIASIS - ITS IMPLICATION IN SYSTEMIC CHEMOTHERAPY OF CUTANEOUS AND MUCOCUTANEOUS DISEASE SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID SODIUM STIBOGLUCONATE; MUCOSAL LEISHMANIASIS; ANTIMONIAL DRUGS; INVITRO; EFFICACY AB We report that in vitro sensitivity to pentavalent antimony (Sb5) of 35 Leishmania isolates as determined by the semiautomated microdilution technique (SAMT) showed an 89% and 86% correlation with clinical outcome after Pentostam and Glucantime treatment, respectively. These results suggest that in over 85% of the cases, the clinical outcome of treatment (cure or failure) could have been predicted by using the SAMT technique. Furthermore, the results clearly indicate that drug resistance is a problem, and that at least in some instances, failure to respond to treatment is due to the parasite as well as patient factors. Strains from Sb5-treated patients with American cutaneous and mucocutaneous disease who fail at least one complete course of Pentostam are as highly non-responsive to this drug as laboratory-proven drug-resistant Leishmania strains. It was determined that some Leishmania isolates are innately less susceptible to Sb5 than others, and that moderate resistance to Sb5 exists in nature. A 10- and 17-fold increase was detected in the 50% inhibitory concentration (IC50) of Sb5 for L. mexicana and L. braziliensis isolates after subcurative treatment of the patients, when compared with the mean IC50 of seven and six isolates from the same endemic areas in Guatemala and Peru, respectively. Thus, we have correlated subcurative treatment to a decrease in drug sensitivity in at least these two cases. Collectively, these results indicate that under Sb5 pressure from undermedication, the parasites inherently most drug resistant are favored. The degree of resistance of a strain to antimony in association with host-specific factors will determine whether the clinical response to treatment with this drug is a total cure or a partial response followed by relapse(s), and possibly secondary unresponsiveness resulting in total resistance to antimony. It is evident from our in vitro test data that the SAMT is an extremely powerful and highly accurate technique for the prediction and determination of drug sensitivity of leishmanial isolates, as well as a means to screen for anti-leishmanial agents. C1 USN,MED RES INST DETACHMENT LIMA PERU,APO,MIAMI,FL 34031. RP GROGL, M (reprint author), WALTER REED ARMY MED CTR,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307, USA. RI Villasante, Eileen/G-3602-2011 NR 17 TC 185 Z9 191 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JUL PY 1992 VL 47 IS 1 BP 117 EP 126 PG 10 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA JF669 UT WOS:A1992JF66900020 PM 1322070 ER PT J AU GUZZI, LM STAMATOS, JM AF GUZZI, LM STAMATOS, JM TI JOBS SYNDROME - AN UNUSUAL RESPONSE TO A COMMON-DRUG SO ANESTHESIA AND ANALGESIA LA English DT Article C1 WALTER REED ARMY MED CTR,OPERAT SERV,WASHINGTON,DC 20307. RP GUZZI, LM (reprint author), WALTER REED ARMY MED CTR,ANESTHESIA SERV,WASHINGTON,DC 20307, USA. NR 9 TC 3 Z9 4 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0003-2999 J9 ANESTH ANALG JI Anesth. Analg. PD JUL PY 1992 VL 75 IS 1 BP 139 EP 140 PG 2 WC Anesthesiology SC Anesthesiology GA JB522 UT WOS:A1992JB52200028 PM 1616142 ER PT J AU MONGAN, PD HOSKING, MP AF MONGAN, PD HOSKING, MP TI THE ROLE OF DESMOPRESSIN ACETATE IN PATIENTS UNDERGOING CORONARY-ARTERY BYPASS-SURGERY - A CONTROLLED CLINICAL-TRIAL WITH THROMBOELASTOGRAPHIC RISK STRATIFICATION SO ANESTHESIOLOGY LA English DT Article DE BLOOD, COAGULATION, DESMOPRESSIN; MEASUREMENT TECHNIQUES, THROMBOELASTOGRAPHY; SURGERY, CARDIAC, CORONARY ARTERY BYPASS GRAFTING ID REDUCE BLOOD-LOSS; CARDIOPULMONARY BYPASS; CARDIAC-SURGERY; EXTRACORPOREAL-CIRCULATION; PLATELET DYSFUNCTION; VONWILLEBRAND-FACTOR; BUBBLE OXYGENATORS; MECHANISM; MEMBRANE; DDAVP AB The role of desmopressin acetate in attenuating blood loss and reducing homologous blood component therapy after cardiopulmonary bypass is unclear. The purpose of this investigation was to identify a subgroup of patients that may benefit from desmopressin acetate therapy. One hundred fifteen patients completed a prospective randomized double-blind, placebo-controlled trial designed to evaluate the effect of desmopressin acetate (0.3-mu-g.kg-1) on mediastinal chest tube drainage after elective coronary artery bypass grafting surgery in patients with normal and abnormal platelet-fibrinogen function as diagnosed by the maximal amplitude (MA) on thromboelastographic (TEG) evaluation. The 115 patients evaluated were divided into two groups based on the MA of the post-cardiopulmonary bypass TEG tracing. Group 1 (TEG:MA > 50 mm) consisted of 86 patients, of whom 44 received desmopressin and 42 received placebo. Twenty-nine patients had abnormal platelet function (TEG:MA < 50 mm) and were designated as group 2. In group 2, 13 received desmopressin and 16 placebo. During the first 24 h after cardiopulmonary bypass, the placebo-treated patients in group 2 had significantly greater mediastinal chest tube drainage when compared to placebo patients in group 1 (1,352.6 +/- 773.1 ml vs. 865.3 +/- 384.4 ml, P = 0.002). In addition to increases in blood loss, group 2 placebo patients also were administered an increased number of blood products (P < 0.05). The desmopressin-treated patients in group 2 neither experienced increased mediastinal chest tube drainage nor received increased amounts of homologous blood products when compared to those in group 1. There was a difference in mediastinal chest tube drainage between placebo and desmopressin patients in group 2 (1,352.6 +/- 773.1 vs. 881.2 +/- 594.6, P = 0.036). There were no differences in the postoperative complications that were evaluated. The results suggest that the TEG (TEG:MA < 50 mm) can identify a patient population at risk for increased mediastinal chest tube drainage. Desmopressin administered to those patients was effective in decreasing the volume of mediastinal chest tube drainage. RP MONGAN, PD (reprint author), BROOKE ARMY MED CTR,DEPT SURG,ANESTHESIA & OPERAT SERV,MED CORPS,FT SAM HOUSTON,TX 78234, USA. NR 38 TC 88 Z9 91 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0003-3022 J9 ANESTHESIOLOGY JI Anesthesiology PD JUL PY 1992 VL 77 IS 1 BP 38 EP 46 DI 10.1097/00000542-199207000-00007 PG 9 WC Anesthesiology SC Anesthesiology GA JB534 UT WOS:A1992JB53400007 PM 1610009 ER PT J AU CRAIG, TJ ENGLER, R YANG, E CARPENTER, G AF CRAIG, TJ ENGLER, R YANG, E CARPENTER, G TI AN ATYPICAL CASE OF IMMUNODEFICIENCY SO ANNALS OF ALLERGY LA English DT Article ID LEUKOCYTE ADHESION DEFICIENCY; MEDIATED GENE-TRANSFER; UMBILICAL-CORD; GLYCOPROTEIN; SEPARATION; INFECTIONS; RECEPTORS; P150,95; LFA-1 C1 WALTER REED ARMY MED CTR,DEPT ALLERGY,WASHINGTON,DC 20307. NR 15 TC 2 Z9 2 U1 0 U2 0 PU AMER COLL ALLERGY ASTHMA IMMUNOLOGY PI ARLINGTON HTS PA 85 WEST ALGONQUIN RD SUITE 550, ARLINGTON HTS, IL 60005 SN 0003-4738 J9 ANN ALLERGY JI Ann. Allergy PD JUL PY 1992 VL 69 IS 1 BP 22 EP 25 PG 4 WC Allergy SC Allergy GA JE395 UT WOS:A1992JE39500004 PM 1352663 ER PT J AU SIDELL, FR BORAK, J AF SIDELL, FR BORAK, J TI CHEMICAL WARFARE AGENTS .2. NERVE AGENTS SO ANNALS OF EMERGENCY MEDICINE LA English DT Article DE CHEMICAL WARFARE AGENTS; NERVE AGENTS RP SIDELL, FR (reprint author), USA,MED RES INST CHEM DEF,DIV CHEM CASUALTY,EDUC BRANCH,ABERDEEN PROVING GROUND,MD 21014, USA. NR 0 TC 106 Z9 109 U1 3 U2 14 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0196-0644 J9 ANN EMERG MED JI Ann. Emerg. Med. PD JUL PY 1992 VL 21 IS 7 BP 865 EP 871 DI 10.1016/S0196-0644(05)81036-4 PG 7 WC Emergency Medicine SC Emergency Medicine GA JB220 UT WOS:A1992JB22000018 PM 1610046 ER PT J AU MOSS, JT BAYSINGER, CL BOSWELL, GW SAYSON, S AF MOSS, JT BAYSINGER, CL BOSWELL, GW SAYSON, S TI POSSIBLE INTRAOPERATIVE ANESTHETIC-SPARING EFFECT OF PARENTERAL KETOROLAC SO ANNALS OF PHARMACOTHERAPY LA English DT Article ID ANTI-INFLAMMATORY PROFILE; POSTOPERATIVE PAIN; MORPHINE-SULFATE; TROMETHAMINE; PENTAZOCINE AB OBJECTIVE: Because the analgesic effects of ketorolac are equivalent to those of narcotic analgesics, we investigated the possibility that this non-steroidal antiinflammatory drug might also exhibit anesthetic-sparing properties similar to those described for narcotic agents. DESIGN: A nonrandomized, double-blind convenience sample. The treatment group received a preoperative dose of ketorolac 60 mg im 45 minutes prior to the induction of anesthesia. All other preoperative medications were identical. SETTING: Brooke Army Medical Center, a primary care setting. PARTICIPANTS: Six women requiring vaginal hysterectomies from American Society of Anesthesiologists class I/II, all of similar age, weight, and body surface area. OUTCOME MEASURES: End-tidal concentrations of the anesthetic gas were measured at five-minute intervals using a gas analyzer. A mean percent end-tidal concentration versus time curve was generated for each group. RESULTS: The area under the concentration curves for the anesthetic gas in the ketorolac and control group were 15.9 +/- 5.1 and 52.3 +/- 13.4, respectively (p=0.006). CONCLUSIONS: Ketorolac exhibits an anesthetic-sparing quality similar to that observed with narcotic analgesics. C1 USA,ACAD HLTH SCI,DIV MED & SURF,PHARM BRANCH,SPECIAL SUBJECTS SECT,FT SAM HOUSTON,TX 78234. BROOKE ARMY MED CTR,DEPT SURG,ANESTHESIA & OPERAT SERV,FT SAM HOUSTON,TX 78234. NR 20 TC 12 Z9 12 U1 0 U2 0 PU HARVEY WHITNEY BOOKS CO PI CINCINNATI PA PO BOX 42696, CINCINNATI, OH 45242 SN 1060-0280 J9 ANN PHARMACOTHER JI Ann. Pharmacother. PD JUL-AUG PY 1992 VL 26 IS 7-8 BP 922 EP 924 PG 3 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA JD753 UT WOS:A1992JD75300012 PM 1504401 ER PT J AU CORTESE, LM BJORNSON, DC AF CORTESE, LM BJORNSON, DC TI THE NEW MACROLIDE ANTIBIOTICS AND TERFENADINE - COMMENT SO ANNALS OF PHARMACOTHERAPY LA English DT Letter RP CORTESE, LM (reprint author), WALTER REED ARMY MED CTR,HENRY M JACKSON FDN,BLDG 1,WARD 11,WASHINGTON,DC 20307, USA. NR 4 TC 1 Z9 1 U1 0 U2 0 PU HARVEY WHITNEY BOOKS CO PI CINCINNATI PA PO BOX 42696, CINCINNATI, OH 45242 SN 1060-0280 J9 ANN PHARMACOTHER JI Ann. Pharmacother. PD JUL-AUG PY 1992 VL 26 IS 7-8 BP 1019 EP 1019 PG 1 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA JD753 UT WOS:A1992JD75300043 PM 1504390 ER PT J AU KARLE, JM KARLE, IL GERENA, L MILHOUS, WK AF KARLE, JM KARLE, IL GERENA, L MILHOUS, WK TI STEREOCHEMICAL EVALUATION OF THE RELATIVE ACTIVITIES OF THE CINCHONA ALKALOIDS AGAINST PLASMODIUM-FALCIPARUM SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID CRYSTAL-STRUCTURE; QUINIDINE; INVITRO; QUININE; MALARIA AB Quinine and quinidine were over 100 times more active than 9-epiquinine and 9-epiquinidine against chloroquine-sensitive Plasmodium falciparum and over 10 times more active against chloroquine-resistant P. falciparum. Since the only structural difference between quinine, quinidine, 9-epiquinine, and 9-epiquinidine is their three-dimensional configuration, the three-dimensional structures of these four alkaloids were examined in order to explain the large difference in relative activities between the 9-epi alkaloids and quinine and quinidine. The crystal structure of 9-epiquinidine hydrochloride monohydrate was determined by X-ray diffraction and was compared with the crystal structures of quinine, quinidine sulfate dihydrate, and 9-epiquinine hydrochloride dihydrate. The crystallographic parameters for 9-epiquinidine hydrochloride monohydrate were as follows: chemical formula, C20H25N2O2+ . Cl- . H2O; M(r), 378.9; symmetry of unit cell, orthorhombic; space group, P2(1)2(1)2(1); parameters of unit cell, a was 7.042 +/- 0.001 angstrom (1 angstrom = 0.1 nm), b was 9.082 +/- 0.001 angstrom, c was 31.007 +/- 0.005 angstrom; the volume of unit cell was 1,983.1 +/- 0.6 angstrom3; number of molecules per unit cell was 4; the calculated density was 1.27 g cm-3; the source of radiation was Cu K-alpha (lambda = 1.54178 angstrom); mu (absorption coefficient) was 18.82 cm-1; F(000) (sum of atomic scattering factors at zero scattering angle) was 808; room temperature was used; final R (residual index) was 5.72% for 1,501 reflections with \F(o)\ > 3-sigma (F). The intramolecular distance from N-1 to 0-12 in 9-epiquinidine and 9-epiquinine, although shorter than the corresponding distance in quinine and quinidine, was similar to those of other active amino alcohol antimalarial agents. In all four alkaloids, both the hydroxyl and amine groups formed intermolecular hydrogen bonds, showing the potential for forming hydrogen bonds with cellular constituents. However, the positioning of the N+-1-H-N1 and O-12-H-O12 groups relative to each other was quite different in the 9-epi alkaloids versus quinidine. This difference in positioning may determine the relative strengths of the formation of hydrogen bonds with cellular constituents important to antimalarial activity and, therefore, may determine the relative strength of antimalarial activity. C1 WALTER REED ARMY MED CTR,DEPT PARASITOL,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307. USN,RES LAB,STRUCT MATTER LAB,WASHINGTON,DC 20375. RP KARLE, JM (reprint author), WALTER REED ARMY MED CTR,DEPT PHARMACOL,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307, USA. NR 27 TC 54 Z9 55 U1 0 U2 3 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD JUL PY 1992 VL 36 IS 7 BP 1538 EP 1544 PG 7 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA JC894 UT WOS:A1992JC89400033 PM 1510452 ER PT J AU HAUGLAND, SM BAHAR, E CARRIERI, AH AF HAUGLAND, SM BAHAR, E CARRIERI, AH TI IDENTIFICATION OF CONTAMINANT COATINGS OVER ROUGH SURFACES USING POLARIZED INFRARED SCATTERING SO APPLIED OPTICS LA English DT Article DE MUELLER MATRIX; MULTIFREQUENCY ELLIPSOMETER; FULL-WAVE APPROACH; REMOTE DETECTION ID FULL-WAVE SOLUTIONS; DEPOLARIZATION; FIELDS AB An optical technique to identify the presence of chemical coatings over rough surfaces is described. It is based on the selective use of elements of the 4 x 4 Mueller matrix. The full-wave theory of electromagnetic scattering is used to predict six independent Mueller elements from randomly rough uncoated (dry) and coated (wet) surface materials as functions of the media complex dielectric coefficients, backscattering angle, and midinfrared wavelengths of laser-beam excitations that are polarization modulated. The set of independent elements at beam wavelengths and backscattering angles [M(mn)(lambda(i), theta(i)] most sensitive to i optically thick contaminant coatings are statistically obtained from the full-wave database, and detection-parameter sets [theta(i), lambda(i)] are inputs to another algorithm designed to identify the contaminant coating (when present and interacted by the irradiating beams). These algorithms facilitate the operation of a multi-CO2 laser-ellipsometer facility now under development at the U.S. Army Chemical Research, Development, and Engineering Center for the remote detection of chemical or biological surface contaminants. C1 USA,CTR CHEM RES DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010. RP HAUGLAND, SM (reprint author), UNIV NEBRASKA,DEPT ELECT ENGN,LINCOLN,NE 68588, USA. NR 7 TC 10 Z9 10 U1 1 U2 2 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0003-6935 J9 APPL OPTICS JI Appl. Optics PD JUL 1 PY 1992 VL 31 IS 19 BP 3847 EP 3852 PG 6 WC Optics SC Optics GA JA461 UT WOS:A1992JA46100036 PM 20725361 ER PT J AU PESCERODRIGUEZ, RA MISER, CS MCNESBY, KL FIFER, RA KESSEL, S STRAUSS, BD AF PESCERODRIGUEZ, RA MISER, CS MCNESBY, KL FIFER, RA KESSEL, S STRAUSS, BD TI CHARACTERIZATION OF SOLID-PROPELLANT AND ITS CONNECTION TO AGING PHENOMENA SO APPLIED SPECTROSCOPY LA English DT Article DE PLASTICIZER MIGRATION; SOLID PROPELLANTS; FT-IR SPECTROSCOPY AB Solid propellant characterization has been performed with the use of three Fourier transform infrared (FT-IR) techniques: FT-IR-microscopy (FT-IR-mic), attenuated total reflectance/FT-IR (ATR/FT-IR) spectroscopy, and desorption/gas chromatography/FT-IR (D/GC/FT-IR) spectroscopy as well as thermogravimetric analysis (TGA). Emphasis was placed on examination of the content and behavior of plasticizer (bis-2,2-dinitropropyl acetal/formal, BDNPA/F) in propellant samples characterized over a 300-day period. Levels of residual solvent and other desorbable materials were examined as well. The following conclusions were made: there are significantly higher levels of both plasticizer and polymeric binder at extruded surfaces than in the interior of propellant grains; the rate of plasticizer migration in binder alone depends on the CAB:NC (cellulose acetate butyrate: nitrocellulose) ratio; and plasticizer evaporation and diffusional migration are negligible for all but one of the samples analyzed, suggesting that plasticizer is probably not responsible for observed aging phenomena. Levels of residual solvent and other minor components were observed to decrease with time under both ambient and accelerated aging conditions and may be related to aging phenomena. C1 USA,ARMAMENT RES,CTR DEV & ENGN,PICATINNY ARSENAL,NJ 07801. RP PESCERODRIGUEZ, RA (reprint author), USA,BALLIST RES LAB,ABERDEEN PROVING GROUND,MD 21005, USA. NR 14 TC 3 Z9 3 U1 1 U2 4 PU SOC APPLIED SPECTROSCOPY PI FREDERICK PA 201B BROADWAY ST, FREDERICK, MD 21701 SN 0003-7028 J9 APPL SPECTROSC JI Appl. Spectrosc. PD JUL PY 1992 VL 46 IS 7 BP 1143 EP 1155 DI 10.1366/0003702924124268 PG 13 WC Instruments & Instrumentation; Spectroscopy SC Instruments & Instrumentation; Spectroscopy GA JD747 UT WOS:A1992JD74700012 ER PT J AU LETTERIE, GS HAGGERTY, MF FELLOWS, DW AF LETTERIE, GS HAGGERTY, MF FELLOWS, DW TI SENSITIVITY OF HYSTEROSALPINGOGRAPHY AFTER TUBAL SURGERY SO ARCHIVES OF GYNECOLOGY AND OBSTETRICS LA English DT Article DE POSTOPERATIVE HYSTEROSALPINGOGRAPHY; LAPAROSCOPY ID INFERTILE PATIENTS; LAPAROSCOPY AB Hysterosalpingography (HSG) to assess tubal patency in the post-operative evaluation of the infertile patient has been well described. However, the sensitivity and specificity of HSG after tubal surgery has not been reported. We correlated HSG and laparoscopic findings in 25 patients who had tubal surgery (microsurgical tubal reanastomoses [11] and distal salpingostomies [14]). HSG provided a more reliable means of assessing tubal patency (sensitivity and specificity of 96% and 61% respectively) than in detecting pelvic adhesive disease (PAD) (sensitivity and specificity of 12% and 75% respectively) regardless of tubal surgical procedure. HSG was associated with a high false negative rate (60%) due primarily to the inability to detect PAD. Complete agreement between HSG and laparoscopy was noted in only 15% of cases. These data suggest that HSG is a sensitive means to determine tubal patency, but was not sufficiently sensitive or specific to detect PAD after tubal surgery. These limitations should be noted in the interpretation of HSG in any infertile patient with a history of tubal surgery, and severely limits the application of HSG to the management of the post-operative infertile patient. C1 TRIPLER ARMY MED CTR,DEPT RADIOL,HONOLULU,HI 96859. RP LETTERIE, GS (reprint author), VIRGINIA MASON CLIN,OBSTET & GYNECOL SECT X8-0B,REPRODUCT ENDOCRINOL SERV,1100 9TH AVE,SEATTLE,WA 98111, USA. NR 11 TC 1 Z9 1 U1 0 U2 0 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0932-0067 J9 ARCH GYNECOL OBSTET JI Arch. Gynecol. Obstet. PD JUL PY 1992 VL 251 IS 4 BP 175 EP 180 DI 10.1007/BF02718383 PG 6 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA JC875 UT WOS:A1992JC87500004 PM 1386980 ER PT J AU STAMBAUGH, KI AF STAMBAUGH, KI TI CHIN AUGMENTATION - AN IMPORTANT ADJUNCTIVE PROCEDURE TO RHINOPLASTY SO ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY LA English DT Article ID POLYAMIDE MESH; MENTOPLASTY; IMPLANTS AB Augmentation mentoplasty is a cosmetic procedure designed specifically to supplement deficient fullness of the mental area. Patients seeking care from rhinoplastic surgeons for nasal corrective procedures may not be aware of a deficiency, which is the most common abnormality in this area. Complete evaluation of the full facial profile, which should be performed in all potential rhinoplasty patients, identifies such abnormalities. The general concepts of preoperative evaluation, corrective options available, including make of implant materials, and complications are discussed. Patients with mild to moderate microgenia can be simply corrected by augmentation mentoplasty to balance the facial profile. The most common method of adding fullness in the chin area is use of an implantable material. This article discusses the advantages and disadvantages of the available materials. RP STAMBAUGH, KI (reprint author), BROOKE ARMY MED CTR,DEPT SURG,FT SAM HOUSTON,TX 78234, USA. NR 19 TC 7 Z9 7 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0886-4470 J9 ARCH OTOLARYNGOL JI Arch. Otolaryngol. Head Neck Surg. PD JUL PY 1992 VL 118 IS 7 BP 682 EP 686 PG 5 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA JC547 UT WOS:A1992JC54700001 PM 1627285 ER PT J AU DILLINGHAM, TR LEHMANN, JF PRICE, R AF DILLINGHAM, TR LEHMANN, JF PRICE, R TI EFFECT OF LOWER-LIMB ON BODY PROPULSION SO ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION LA English DT Article DE AMBULATION; BIOMECHANICS; GAIT; KINESIOLOGY ID ENERGY AB The purpose of this study was to analyze and compare the effects of the leg during swing and stance phases of forward propulsion of the body for both men and women. Twelve able-bodied subjects, six men and six women, were studied with a Vicon(a) gait-analysis system. A two-dimensional, sagittal-plane biomechanical analysis featuring a link-segment model was used to determine the force at the hip in the horizontal direction. Integrating this force curve over time during the swing and stance gait phases produced linear impulses, representing swing and stance contributions to the propulsion of the body, and it allowed quantitative comparisons using student t and Fisher tests. The deceleration of the swing leg was found to be the major contributor to the forward propulsion of the body. The stance leg initially exerted the major restraining or negative impulse during early stance; then it generated a positive impulse during push-off in late stance. A typical pattern of gait impulses was defined for normal gait. Male and female gait impulses were not significantly different for all gait phases. C1 UNIV WASHINGTON,DEPT PHYS MED & REHABIL,SEATTLE,WA 98195. RP DILLINGHAM, TR (reprint author), WALTER REED ARMY MED CTR,PHYS MED & REHABIL SERV,WASHINGTON,DC 20307, USA. NR 13 TC 27 Z9 27 U1 0 U2 5 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0003-9993 J9 ARCH PHYS MED REHAB JI Arch. Phys. Med. Rehabil. PD JUL PY 1992 VL 73 IS 7 BP 647 EP 651 PG 5 WC Rehabilitation; Sport Sciences SC Rehabilitation; Sport Sciences GA JD139 UT WOS:A1992JD13900008 PM 1622320 ER PT J AU CARTER, RM AF CARTER, RM TI A NEW GENERATION OF UNITED-STATES-ARMY FLIGHT HELMETS SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Note AB Head injuries are the most common cause of fatal injury in helicopter crashes. For over 80 years, the U.S. Army has used crash investigation studies to redesign flight helmets. This paper describes the evolution of the newly fielded U.S. Army helmet, the Sound Protection Helmet No. 4B (SPH-4B), and compares its protective features to its predecessors, especially the SPH-4. A major contribution to the helmet design process was made by the Aviation Life Support Equipment Retrieval Program (ALSERP), a functional program at the U.S. Army Aeromedical Research Laboratory (USAARL). ALSERP has analyzed more than 500 helmets involved in crash events since 1972. Based on these studies of critical safety factors, the Army has developed and deployed the SPH-4B, a new helmet with improved energy absorption, retention, and stability. C1 USA,SCH AVIAT MED,FT RUCKER,AL 36360. NR 7 TC 3 Z9 3 U1 0 U2 1 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD JUL PY 1992 VL 63 IS 7 BP 629 EP 633 PG 5 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA JA489 UT WOS:A1992JA48900014 PM 1616442 ER PT J AU WESENSTEN, NJ BADIA, P AF WESENSTEN, NJ BADIA, P TI TIME OF DAY AND SEMANTIC CATEGORY EFFECTS ON LATE COMPONENTS OF THE VISUAL ERP SO BIOLOGICAL PSYCHOLOGY LA English DT Article ID EVENT-RELATED POTENTIALS; EXCESSIVE DAYTIME SLEEPINESS; DIURNAL-VARIATION; BRAIN POTENTIALS; NARCOLEPSY-CATAPLEXY; EVOKED-POTENTIALS; P300 AMPLITUDE; CATEGORIZATION; SENTENCES; RETRIEVAL AB The N100, P200, N400 and P600 components of the visual event-related potential were recorded from 11 female subjects every 2 h from 09:00 to 21:00 hours using a semantic categorization task. All subjects scored as "Intermediate" or marginal "Evening" types on a Morningness-Eveningness questionnaire. Amplitude and latency of components, tympanic temperature, and performance measures for positive and negative category instances were assessed. Amplitude of P200 increased across the day. Amplitude of N400 was larger, and latency of P600 was longer, for negative category instances, but neither component varied with time of day. N100 was unaffected by time of day. The results suggest that previous reports of diurnal variations in visual N100-P200 were due to variations in P200 alone, and that diurnal variations in P200 may reflect diurnal variations in underlying arousal levels. In addition, overlap with P600 may have obscured time of day effects for N400. C1 BOWLING GREEN STATE UNIV,BOWLING GREEN,OH 43403. RP WESENSTEN, NJ (reprint author), WALTER REED ARMY MED CTR,DEPT BEHAV BIOL,WASHINGTON,DC 20307, USA. NR 44 TC 10 Z9 10 U1 1 U2 4 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0301-0511 J9 BIOL PSYCHOL JI Biol. Psychol. PD JUL PY 1992 VL 33 IS 2-3 BP 173 EP 193 DI 10.1016/0301-0511(92)90030-X PG 21 WC Psychology, Biological; Behavioral Sciences; Psychology; Psychology, Experimental SC Psychology; Behavioral Sciences GA JJ800 UT WOS:A1992JJ80000005 PM 1525293 ER PT J AU MCLEOD, DG CRAWFORD, ED BLUMENSTEIN, BA EISENBERGER, MA DORR, FA AF MCLEOD, DG CRAWFORD, ED BLUMENSTEIN, BA EISENBERGER, MA DORR, FA TI CONTROVERSIES IN THE TREATMENT OF METASTATIC PROSTATE-CANCER SO CANCER LA English DT Article; Proceedings Paper CT INTERNATIONAL WORKSHOP ON PROSTATIC CANCER AND HYPERPLASIA CY OCT 26-29, 1991 CL SEA ISLAND, GA SP AMER CANC SOC, AMER UROL ASSOC DE PROSTATE CANCER, COMBINED ANDROGEN BLOCKADE, METASTATIC DISEASE ID CARCINOMA AB Background. Prostate cancer is the most common cancer in American men today. Unfortunately, at the time of diagnosis, most men will have either regional or distant metastatic disease. Methods. Six hundred three patients with advanced prostate cancer who could be examined were randomized in a double-blind, placebo-controlled trial to receive the luteinizing hormone-releasing hormone [LHRH] agonist leuprolide with either flutamide or placebo. Results. Patients receiving the combined therapy arm of leuprolide and flutamide had an increased progression-free survival time of 16.9 versus 13.8 months and a survival advantage of 35.1 versus 20.3 months. A more striking difference was found in the subset of patients receiving combination therapy who had good performance and minimal disease. Conclusions. There appears to be a definite advantage of combination therapy over leuprolide alone, especially in patients with minimal disease and good performance. Another larger intergroup study using orchiectomy and flutamide versus orchiectomy and placebo is currently underway. C1 UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. RP MCLEOD, DG (reprint author), WALTER REED ARMY MED CTR,UROL SERV,WASHINGTON,DC 20307, USA. NR 18 TC 12 Z9 12 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0008-543X J9 CANCER JI Cancer PD JUL 1 PY 1992 VL 70 IS 1 SU S BP 324 EP 328 DI 10.1002/1097-0142(19920701)70:1+<324::AID-CNCR2820701321>3.0.CO;2-G PG 5 WC Oncology SC Oncology GA JA174 UT WOS:A1992JA17400019 PM 1600494 ER PT J AU NEWLING, DWW MCLEOD, D SOLOWAY, M DISILVERIO, F SMITH, P AF NEWLING, DWW MCLEOD, D SOLOWAY, M DISILVERIO, F SMITH, P TI DISTANT DISEASE SO CANCER LA English DT Discussion C1 WALTER REED ARMY MED CTR,UROL SERV,WASHINGTON,DC 20307. ST JAMES UNIV HOSP,DEPT UROL,LEEDS LS9 7TF,W YORKSHIRE,ENGLAND. UNIV TENNESSEE CTR HLTH SCI,COLL MED,DEPT UROL,MEMPHIS,TN 38163. NR 0 TC 4 Z9 4 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0008-543X J9 CANCER JI Cancer PD JUL 1 PY 1992 VL 70 IS 1 SU S BP 365 EP 367 DI 10.1002/1097-0142(19920701)70:1+<365::AID-CNCR2820701331>3.0.CO;2-8 PG 3 WC Oncology SC Oncology GA JA174 UT WOS:A1992JA17400029 PM 1600496 ER PT J AU MORRIS, JT JOYCE, MP AF MORRIS, JT JOYCE, MP TI CENTRAL-NERVOUS-SYSTEM TUBERCULOMA PRESENTING AS A CAVERNOUS SINUS TUMOR SO CLINICAL INFECTIOUS DISEASES LA English DT Letter ID INTRACRANIAL TUBERCULOMAS; COMPUTERIZED-TOMOGRAPHY; MANAGEMENT RP MORRIS, JT (reprint author), BROOKE ARMY MED CTR,DEPT MED,INFECT DIS SERV,FT SAM HOUSTON,TX 78234, USA. NR 9 TC 13 Z9 13 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD JUL PY 1992 VL 15 IS 1 BP 181 EP 182 PG 2 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA JA300 UT WOS:A1992JA30000038 PM 1617066 ER PT J AU ROBERTSON, FM WHEELER, R OLSEN, SB JACKSON, MR AF ROBERTSON, FM WHEELER, R OLSEN, SB JACKSON, MR TI DAPSONE HEPATITIS FOLLOWING TREATMENT OF A BROWN RECLUSE SPIDER BITE SO COMPLICATIONS IN SURGERY LA English DT Article DE DRUG TOXICITY; ALLERGIC REACTIONS; ANTIBIOTICS; COMPLICATIONS, ANTIBIOTIC; HEPATITIS AB Dapsone therapy for brown recluse spider bites has been shown to be an effective alternative to early surgical excision. Because of the increasing use of dapsone, clinicians must be aware of its potential toxic manifestations. The dapsone hypersensitivity syndrome occurred in a 37-year-old man, following treatment of a brown recluse spider bite. RP ROBERTSON, FM (reprint author), BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SCP COMMUNICATIONS INC PI NEW YORK PA 134 W 29TH ST, NEW YORK, NY 10001-5304 SN 1053-749X J9 COMPLICATION SURG JI Complicat. Surg. PD JUL-AUG PY 1992 VL 11 IS 7 BP 33 EP 35 PG 3 WC Surgery SC Surgery GA JG196 UT WOS:A1992JG19600006 ER PT J AU WHITNALL, MH PERLSTEIN, RS MOUGEY, EH NETA, R AF WHITNALL, MH PERLSTEIN, RS MOUGEY, EH NETA, R TI EFFECTS OF INTERLEUKIN-1 ON THE STRESS-RESPONSIVE AND STRESS-NONRESPONSIVE SUBTYPES OF CORTICOTROPIN-RELEASING HORMONE NEUROSECRETORY AXONS SO ENDOCRINOLOGY LA English DT Article ID PITUITARY-ADRENAL AXIS; FREELY-MOVING RATS; MEDIAN-EMINENCE; ADRENALECTOMIZED RATS; PROLACTIN SECRETION; MULTIPLE HORMONES; ACTH-SECRETION; LEWIS RATS; VASOPRESSIN; NEURONS AB Administration of interleukin-1 (IL-1) induces increases in plasma ACTH and glucocorticoids. Numerous experiments have implicated the hypothalamic CRH neurosecretory system in these responses, but have failed to provide evidence for involvement of the ACTH secretagogue vasopressin (VP). The rat CRH neurosecretory system contains two types of cells: VP expressing and VP deficient. Hence, the above findings suggested that IL-1 may selectively activate the VP-deficient subtype of CRH neurosecretory cells. In this study we employed postembedding electron microscopic immunocytochemistry to directly assay IL-1-induced depletion of secretory vesicles from identified VP-expressing and VP-deficient CRH neurosecretory axons. IL-1-induced depletion of secretory vesicles from these axons was correlated with increases in plasma ACTH and decreases in plasma PRL. No dose of IL-1 was found that could selectively activate one subtype of CRH neurosecretory axons; at doses of 0.67-mu-g/100 g and above for both IL-1-alpha and IL-1-beta, equal depletion of vesicles from the two subtypes was observed. Similar results were previously found after the injection of bacterial lipopolysaccharide, which induces the release of IL-1 from macrophages. The findings unequivocally establish for the first time that IL-1 activates hypothalamic CRH neurosecretory cells in the absence of surgical stress, anesthesia, disruption of the infundibular area, or administration of toxic drugs. In addition, these data clearly demonstrate that IL-1 induces the release of VP from neurosecretory axons in the portal capillary zone of the external zone of the median eminence. Previous studies have shown that the VP-deficient subtype of CRH neurosecretory axons is not strongly activated by several types of stress; therefore, activation of the system by inflammatory mediators involves mechanisms different from those mediating the stress response. C1 ARMED FORCES RADIOBIOL RES INST, DEPT EXPTL HEMATOL, BETHESDA, MD 20889 USA. WALTER REED ARMY MED CTR, DEPT MED NEUROSCI, NEUROENDOCRINOL & NEUROCHEM BRANCH, WASHINGTON, DC 20307 USA. RP ARMED FORCES RADIOBIOL RES INST, DEPT PHYSIOL, BETHESDA, MD 20889 USA. NR 60 TC 62 Z9 62 U1 0 U2 0 PU ENDOCRINE SOC PI WASHINGTON PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA SN 0013-7227 EI 1945-7170 J9 ENDOCRINOLOGY JI Endocrinology PD JUL PY 1992 VL 131 IS 1 BP 37 EP 44 DI 10.1210/en.131.1.37 PG 8 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA JC258 UT WOS:A1992JC25800007 PM 1319322 ER PT J AU SCHWARTZ, GN KESSLER, SW AF SCHWARTZ, GN KESSLER, SW TI STEM-CELL GROWTH-FACTOR (SCF) ENHANCED INTERLEUKIN-3-INDUCED MYELOPOIESIS IN SERUM-DEPRIVED LIQUID CULTURES OF CD34+ HUMAN MARROW-CELLS SO EXPERIMENTAL HEMATOLOGY LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. USN,MED RES INST,BETHESDA,MD 20814. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CARDEN JENNINGS PUBL CO LTD PI CHARLOTTESVILLE PA BLAKE CTR, STE 200, 1224 W MAIN ST, CHARLOTTESVILLE, VA 22903 SN 0301-472X J9 EXP HEMATOL JI Exp. Hematol. PD JUL PY 1992 VL 20 IS 6 BP 803 EP 803 PG 1 WC Hematology; Medicine, Research & Experimental SC Hematology; Research & Experimental Medicine GA JA734 UT WOS:A1992JA73400378 ER PT J AU SHERMAN, KE JONES, C AF SHERMAN, KE JONES, C TI HEPATOTOXICITY ASSOCIATED WITH PIROXICAM USE SO GASTROENTEROLOGY LA English DT Letter C1 TRIPLER ARMY MED CTR,HONOLULU,HI 96859. RP SHERMAN, KE (reprint author), FITZSIMONS ARMY MED CTR,GASTROENTEROL SERV,AURORA,CO 80045, USA. NR 2 TC 9 Z9 9 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0016-5085 J9 GASTROENTEROLOGY JI Gastroenterology PD JUL PY 1992 VL 103 IS 1 BP 354 EP 355 PG 2 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA JA835 UT WOS:A1992JA83500055 PM 1612350 ER PT J AU KADAKIA, SC STARNES, E AF KADAKIA, SC STARNES, E TI COMPARISON OF 10 FRENCH GAUGE STENT WITH 11.5 FRENCH GAUGE STENT IN PATIENTS WITH BILIARY-TRACT DISEASES SO GASTROINTESTINAL ENDOSCOPY LA English DT Article ID MALIGNANT OBSTRUCTIVE-JAUNDICE; ENDOSCOPIC MANAGEMENT; PALLIATIVE TREATMENT; DUCT STRICTURES; FOLLOW-UP; PROSTHESES; ENDOPROSTHESIS; EXPERIENCE; DRAINAGE AB We retrospectively compared the efficacy and complications of 10 F biliary stents with 11.5 F stents in the management of malignant and benign biliary tract diseases. Thirty-three patients treated with 10 F stents inserted on 46 occasions and 30 patients with 11.5 F stents inserted on 43 occasions were evaluated. The success of insertion, relief of jaundice, decline in total bilirubin, stent survival, and complications due to stents were compared. Patients with multiple stents, pre-operative biliary drainage, stents smaller than 10 F, larger than 11.5 F, nasobiliary catheter drainage, and percutaneous biliary drainage were excluded. When comparing 10 F stents to 11.5 F stents, the success of insertion was 85% vs. 79% (p = 0.52), relief of jaundice was 88% vs. 90% (p = 0.79), and the decline in total bilirubin was 7.4 mg/100 ml vs. 8.3 mg/100 ml (p = 0.67). The complications, including stent clogging, cholangitis, stent migration, and pancreatitis occurred on seven occasions in patients with 10 F stents and on six occasions in patients with 11.5 F stents. This difference was statistically not significant (p = 0.87). We conclude that 10 F stents have the same success rate and complication rate as 11.5 F stents in the management of biliary tract diseases, and offer no significant advantage. RP KADAKIA, SC (reprint author), BROOKE ARMY MED CTR,DEPT MED,GASTROENTEROL SERV,FT SAM HOUSTON,TX 78234, USA. NR 23 TC 51 Z9 51 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0016-5107 J9 GASTROINTEST ENDOSC JI Gastrointest. Endosc. PD JUL-AUG PY 1992 VL 38 IS 4 BP 454 EP 459 DI 10.1016/S0016-5107(92)70476-3 PG 6 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA JJ192 UT WOS:A1992JJ19200011 PM 1511821 ER PT J AU HESS, K IAFRATE, GJ AF HESS, K IAFRATE, GJ TI APPROACHING THE QUANTUM LIMIT SO IEEE SPECTRUM LA English DT Article C1 USA,RES OFF,RES TRIANGLE PK,NC. RP HESS, K (reprint author), UNIV ILLINOIS,ELECT & COMP ENGN,URBANA,IL 61801, USA. NR 4 TC 13 Z9 13 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9235 J9 IEEE SPECTRUM JI IEEE Spectr. PD JUL PY 1992 VL 29 IS 7 BP 44 EP 49 DI 10.1109/6.144511 PG 6 WC Engineering, Electrical & Electronic SC Engineering GA JB414 UT WOS:A1992JB41400012 ER PT J AU VIG, JR AF VIG, JR TI IEEE ULTRASONICS, FERROELECTRICS, AND FREQUENCY CONTROL SOCIETY DISTINGUISHED LECTURER PROGRAM - HIGH-ACCURACY OSCILLATORS AND CLOCKS SO IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL LA English DT Editorial Material RP VIG, JR (reprint author), USA,ELECTR TECHNOL & DEVICES LAB,LABCOM,FT MONMOUTH,NJ 07703, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0885-3010 J9 IEEE T ULTRASON FERR JI IEEE Trans. Ultrason. Ferroelectr. Freq. Control PD JUL PY 1992 VL 39 IS 4 BP 457 EP 457 PG 1 WC Acoustics; Engineering, Electrical & Electronic SC Acoustics; Engineering GA JF037 UT WOS:A1992JF03700001 ER PT J AU KOSINSKI, JA GUALTIERI, JG BALLATO, A AF KOSINSKI, JA GUALTIERI, JG BALLATO, A TI THERMOELASTIC COEFFICIENTS OF ALPHA-QUARTZ SO IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL LA English DT Article ID CRYSTALS AB Experimental measurements of alpha quartz thermal expansion as reported in the literature have been critically analyzed. A recommended set of best measured values over the temperature range -50-degrees-C to +150-degrees-C have been determined, as have values for the coefficient of thermal linear expansion (CTE) and the thermoelastic coefficients alpha(ij)(n). The new alpha(ij)(n) values are alpha-11(1) = 13.65 x 10(-6)/K, alpha-11(2) = 11.02 x 10(-9)/K2, alpha-11(3) = -19.32 x 10(-12)/K3, alpha-33(1) = 7.50 x 10(-6)/K, alpha-33(2) = 8.00 x 10(-9)/K2, alpha-33(3) = -10.44 x 10(-12)/K3. The impact of using the new alpha(ij)(n) on determinations of quartz material temperature coefficients and on the calculation of temperature coefficients of frequency for the case of the AT-cut is discussed. C1 USA,ETDL,SLCET DS,FT MONMOUTH,NJ 07703. RP KOSINSKI, JA (reprint author), USA,DIV ANALOG SIGNAL PROC & DEVICES,ELECTR TECHNOL & DEVICES LAB,FT MONMOUTH,NJ 07703, USA. NR 23 TC 5 Z9 5 U1 2 U2 4 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0885-3010 J9 IEEE T ULTRASON FERR JI IEEE Trans. Ultrason. Ferroelectr. Freq. Control PD JUL PY 1992 VL 39 IS 4 BP 502 EP 507 DI 10.1109/58.148541 PG 6 WC Acoustics; Engineering, Electrical & Electronic SC Acoustics; Engineering GA JF037 UT WOS:A1992JF03700008 PM 18267662 ER PT J AU LEMLEY, PV WRIGHT, DC AF LEMLEY, PV WRIGHT, DC TI MICE ARE ACTIVELY IMMUNIZED AFTER PASSIVE MONOCLONAL-ANTIBODY PROPHYLAXIS AND RICIN TOXIN CHALLENGE SO IMMUNOLOGY LA English DT Note AB Mice passively immunized by a protective, anti-ricin A-chain monoclonal antibody, then challenged intravenously with ricin, were protected from a subsequent ricin challenge, and were actively immunized. Two significant advantages accrued from this experiment: the monoclonal antibody neutralized the toxicity of the ricin immunogen, and active immunization was achieved with very low antigen load (approximately 0.5-mu-g/mouse). We ruled out the possibility that residual monoclonal antibody provided the protection by using three independent criteria. There was significant (four orders of magnitude) enhancement of the immune response in the presence of the monoclonal antibody; control immunizations of mice with ricin A-chain, ricin B-chain or either chain with the monoclonal antibody did not induce active immunity; and the active immunization could not be replicated when protective goat polyclonal antibody was substituted for the monoclonal antibody. Because high titres were achieved rapidly without any adjuvant, we are currently investigating haptenized ricin to determine if anti-hapten monoclonal antibodies can be produced by this refined procedure. C1 UNIVAX BIOL,ROCKVILLE,MD. RP LEMLEY, PV (reprint author), USA,MED RES INST INFECT DIS,DIV PATHOPHYSIOL,DIV TOXINOL,FT DETRICK,MD 21702, USA. NR 4 TC 16 Z9 18 U1 0 U2 1 PU BLACKWELL SCIENCE LTD PI OXFORD PA OSNEY MEAD, OXFORD, OXON, ENGLAND OX2 0EL SN 0019-2805 J9 IMMUNOLOGY JI Immunology PD JUL PY 1992 VL 76 IS 3 BP 511 EP 513 PG 3 WC Immunology SC Immunology GA JD876 UT WOS:A1992JD87600028 PM 1526657 ER PT J AU KOMISAR, J RIVERA, J VEGA, A TSENG, J AF KOMISAR, J RIVERA, J VEGA, A TSENG, J TI EFFECTS OF STAPHYLOCOCCAL ENTEROTOXIN-B ON RODENT MAST-CELLS SO INFECTION AND IMMUNITY LA English DT Article ID INDUCED HISTAMINE-RELEASE; LIMITED TRYPTIC HYDROLYSIS; BASOPHILIC LEUKEMIA-CELLS; HUMAN T-CELLS; ARACHIDONIC-ACID; IA GLYCOPROTEINS; MEDIATOR RELEASE; RAT THYMUS; PEPTIDES; IGE AB Staphylococcal enterotoxin B (SEB) was tested in rodent mast cell cultures for the release of serotonin. Both rat RBL-2H3 mast cells and murine peritoneal cells released serotonin after SEB stimulation in culture. Release of serotonin in RBL-2H3 cells depended on the concentration of SEB; an appreciable release was seen at 50-mu-g/ml. The release of serotonin was not due to cell death. Serotonin release could be enhanced by bradykinin but not by vasoactive intestinal peptide, substance P, lipopolysaccharide from Salmonella typhimurium, the calcium ionophore A23187, acetylcholine, adenosine, 5-hydroxyeicosatetraenoic acid, indomethacin, or Phorbol myristate acetate. SEB bound directly to the membrane of RBL-2H3 mast cells, and the SEB-binding site, the presumptive receptor, appeared to be a protein. The SEB receptor could not be capped under membrane-capping conditions, and serotonin release could not be enhanced by attempts to cross-link the receptor. These results suggest that mast cells may be an important cell type involved in SEB toxicosis and that release of serotonin may be enhanced by activation of the kinin-kallikrein system. RP KOMISAR, J (reprint author), WALTER REED ARMY MED CTR,DIV PATHOL,DEPT EXPTL PATHOL,WASHINGTON,DC 20307, USA. NR 56 TC 32 Z9 33 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD JUL PY 1992 VL 60 IS 7 BP 2969 EP 2975 PG 7 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA JB247 UT WOS:A1992JB24700059 PM 1377185 ER PT J AU LEUTHAUSER, SWC THOMAS, JE GUERNSEY, DL AF LEUTHAUSER, SWC THOMAS, JE GUERNSEY, DL TI ONCOGENES IN X-RAY-TRANSFORMED C3H 10T1/2 MOUSE CELLS AND IN X-RAY-INDUCED MOUSE FIBROSARCOMA (RIF-1) CELLS SO INTERNATIONAL JOURNAL OF RADIATION BIOLOGY LA English DT Article ID RADIATION-INDUCED TRANSFORMATION; K-RAS; C-MYC; NEOPLASTIC TRANSFORMATION; C3H-10T1/2 CELLS; THYROID-HORMONE; INVITRO; DNA; ACTIVATION; INTEGRATION AB In order to better understand the molecular basis of X-ray induced carcinogenesis we have investigated RNA levels of oncogenes in an X-ray transformed C3H 10T1/2 fibroblast line (XTD) and RIF-I cells isolated from an X-ray-induced fibrosarcoma in a C3H mouse. Steady-state levels of K-ras, H-ras, N-ras, abl, sis, src, and fos were unchanged in the X-ray-transformed cells compared with non-transformed C3H 10T1/2 cells. However, myc and raf mRNA levels were increased dramatically in thc transformed cells. Data further suggests a possible alteration in processing of raf RNA in the XTD cells. Southern blot analysis of secondary transfectants induced with XTD DNA indicated that the oncogenic phenotype did not segregate with the myc or raf loci; nor with nine other oncogenes analysed. C1 DALHOUSIE UNIV,FAC MED,DEPT PATHOL,SIR CHARLES TUPPER MED BLDG,HALIFAX B3H 4H7,NS,CANADA. DALHOUSIE UNIV,FAC MED,DEPT PHYSIOL & BIOPHYS,HALIFAX B3H 4H7,NS,CANADA. USA,HLTH CLIN,ROCK ISL,IL 61299. UNIV PENN,SCH MED,HOWARD HUGHES MED INST,DEPT MICROBIOL,PHILADELPHIA,PA 19104. FU NCI NIH HHS [CA36483] NR 43 TC 8 Z9 8 U1 0 U2 0 PU TAYLOR & FRANCIS LTD PI LONDON PA ONE GUNDPOWDER SQUARE, LONDON, ENGLAND EC4A 3DE SN 0955-3002 J9 INT J RADIAT BIOL JI Int. J. Radiat. Biol. PD JUL PY 1992 VL 62 IS 1 BP 45 EP 51 DI 10.1080/09553009214551811 PG 7 WC Biology; Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical Imaging SC Life Sciences & Biomedicine - Other Topics; Nuclear Science & Technology; Radiology, Nuclear Medicine & Medical Imaging GA JH074 UT WOS:A1992JH07400005 PM 1353775 ER PT J AU LIEBESMAN, L SHAW, R MEAGHER, J MOYER, S DICKEY, GE GOLDSTEIN, E WENDEL, DP AF LIEBESMAN, L SHAW, R MEAGHER, J MOYER, S DICKEY, GE GOLDSTEIN, E WENDEL, DP TI PROTECTING WETLANDS SO JOURNAL AMERICAN WATER WORKS ASSOCIATION LA English DT Article C1 USA,CIVIL WORKS,THE PENTAGON,WASHINGTON,DC 20310. OEOB,WASHINGTON,DC. US EPA,DIV WETLANDS,WASHINGTON,DC 20460. NATL WILDLIFE FEDERAT,DIV FISHERIES & WILDLIFE,WASHINGTON,DC 20036. RP LIEBESMAN, L (reprint author), SEMMES BOWEN & SEMMES,250 W PRATT ST,BALTIMORE,MD 21207, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER WATER WORKS ASSOC PI DENVER PA 6666 W QUINCY AVE, DENVER, CO 80235 SN 0003-150X J9 J AM WATER WORKS ASS JI J. Am. Water Work Assoc. PD JUL PY 1992 VL 84 IS 7 BP 26 EP & PG 0 WC Engineering, Civil; Water Resources SC Engineering; Water Resources GA JF094 UT WOS:A1992JF09400005 ER PT J AU ZAGURY, D BERNARD, J HALBREICH, A BIZZINI, B CARELLI, C ACHOUR, A DEFER, MC BERTHO, JM LANNEVAL, K ZAGURY, JF SALAUN, JJ LURHUMA, Z MBAYO, K ABOUDPIRAK, E LOWELL, G LEBON, P BURNY, A AF ZAGURY, D BERNARD, J HALBREICH, A BIZZINI, B CARELLI, C ACHOUR, A DEFER, MC BERTHO, JM LANNEVAL, K ZAGURY, JF SALAUN, JJ LURHUMA, Z MBAYO, K ABOUDPIRAK, E LOWELL, G LEBON, P BURNY, A TI ONE-YEAR FOLLOW-UP OF VACCINE THERAPY IN HIV-INFECTED IMMUNE-DEFICIENT INDIVIDUALS - A NEW STRATEGY SO JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY LA English DT Article DE IMMUNE THERAPY; VACCINE; HIV INFECTION; IMMUNE SUPPRESSION; HIV PEPTIDES; CELL-MEDIATED IMMUNITY; INTERFERON-ALPHA ID HUMAN-IMMUNODEFICIENCY-VIRUS; TOXIC LYMPHOCYTES-T; AIDS; COMPLEX AB Immunization of AIDS/ARC patients with autologous cells expressing HIV antigens, although providing clinical and biological benefits, fails to restore cellular immunity. The latter result is due partly to the antiproliferative effect of HIV-1 on activated T-cells (immune suppression), which leads to blockade of specific immune reactions. To overcome immune suppression, a new vaccine strategy was designed consisting of an immunization against HIV-1 combined with components of the T-cell-suppressive (antiproliferative) network. This new vaccine treatment proved to be innocuous in mice, monkeys, and two non-HIV-infected humans. A Phase I clinical trial was performed in six patients previously under cellular immunotherapy and still presenting a cellular immune defect. Preliminary results confirmed, after a 1-year follow-up of the patients, the safety of the new vaccine, which also partially restored the cellular immune response, including anti-HIV HLA-restricted cell-mediated cytotoxicity, delayed hypersensitivity to recall antigens, and proliferation of T-cells specifically activated by recall antigens. C1 CLIN UNIV KINSHASA,KINSHASA,ZAIRE. USA,ISRAEL WALTER REED ARMY INST RES,RES UNIT,WASHINGTON,DC 20310. UNIV LIBRE BRUXELLES,B-1050 BRUSSELS,BELGIUM. INST PASTEUR,F-75724 PARIS 15,FRANCE. INSERM,U36,F-75005 PARIS,FRANCE. HOP ST ANTOINE,SERV PROFESSEUR JC IMBERT,F-75571 PARIS 12,FRANCE. HOP ST VINCENT DE PAUL,F-75674 PARIS 14,FRANCE. INST JEAN GODINOI,IMMUNOL LAB,F-51056 REIMS,FRANCE. INRB,KINSHASA,ZAIRE. WEIZMANN INST SCI,IL-76100 REHOVOT,ISRAEL. RP ZAGURY, D (reprint author), UNIV PARIS 06,PHYSIOL CELLULAIRE LAB,4 PL JUSSIEU,TOUR 32,BP 198,F-75252 PARIS,FRANCE. NR 16 TC 34 Z9 34 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 1077-9450 J9 J ACQ IMMUN DEF SYND JI J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. PD JUL PY 1992 VL 5 IS 7 BP 676 EP 681 PG 6 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA JB263 UT WOS:A1992JB26300005 PM 1613665 ER PT J AU TUNICK, A RACHELE, H AF TUNICK, A RACHELE, H TI ASSESSMENT OF ONE-DIMENSIONAL ICING FORECAST MODEL APPLIED TO STRATIFORM CLOUDS SO JOURNAL OF AIRCRAFT LA English DT Article; Proceedings Paper CT 29TH AEROSPACE SCIENCES MEETING CY JAN 07-10, 1991 CL RENO, NV SP AMER INST AERONAUT & ASTRONAUT AB Aircraft icing can seriously impair aircraft performance. In this paper we assess a one-dimensional icing forecast model (presently residing at the U.S. Army Atmospheric Sciences Laboratory) by using recent airborne collected microphysics data. Our prime interest was the variation of potential aircraft icing in stratiform clouds. We discuss the king model microphysics, including algorithms used to determine icing severity indices, temperature, liquid water content (LWC), and median volume diameter (MVD) of supercooled water droplets. Output from the one-dimensional model suggests that the icing potential in stratiform clouds does not exceed "light." The model more often forecasts "trace" icing for both fixed-wing aircraft and helicopters. The model does not compute a value for LWC great enough to allow for more serious icing events. We therefore conclude that a method must be established to obtain better estimates of drop-size characteristics and LWC (for stratus clouds) to forecast the full range of potential king for Army aircraft. Otherwise when using the one-dimensional model as currently structured, one would not expect any more than "light" icing when stratus clouds are observed. RP TUNICK, A (reprint author), USA,ATMOSPHER SCI LAB,WHITE SANDS MISSILE RANGE,NM 88002, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091 SN 0021-8669 J9 J AIRCRAFT JI J. Aircr. PD JUL-AUG PY 1992 VL 29 IS 4 BP 703 EP 706 DI 10.2514/3.46223 PG 4 WC Engineering, Aerospace SC Engineering GA JG857 UT WOS:A1992JG85700028 ER PT J AU SAWKA, MN YOUNG, AJ LATZKA, WA NEUFER, PD QUIGLEY, MD PANDOLF, KB AF SAWKA, MN YOUNG, AJ LATZKA, WA NEUFER, PD QUIGLEY, MD PANDOLF, KB TI HUMAN TOLERANCE TO HEAT STRAIN DURING EXERCISE - INFLUENCE OF HYDRATION SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE CORE TEMPERATURE; EUHYDRATION; HEAT EXCHANGE; HEAT EXHAUSTION; HYPOHYDRATION; TEMPERATURE REGULATION ID RESPONSES; TEMPERATURE AB This study determined whether 1) exhaustion from heat strain occurs at the same body temperatures during exercise in the heat when subjects are euhydrated as when they are hypohydrated, 2) aerobic fitness influences the body temperature at which exhaustion from heat strain occurs, and 3) curves could be developed to estimate exhaustion rates at a given level of physiological strain. Seventeen heat-acclimated men [maximal oxygen uptake (VO2 max) from 45 to 65 ml . kg-1 . min-1] attempted two heat stress tests (HSTs): one when euhydrated and one when hypohydrated by 8% of total body water. The HSTs consisted of 180 min of rest and treadmill walking (45% VO2 max) in a hot-dry (ambient temperature 49-degrees-C, relative humidity 20%) environment. The required evaporative cooling (E(req)) exceeded the maximal evaporative cooling capacity of the environment (E(max)); thus thermal equilibrium could not be achieved and 27 of 34 HSTs ended by exhaustion from heat strain. Our findings concerning exhaustion from heat strain are 1) hypohydration reduced the core temperature that could be tolerated; 2) aerobic fitness, per se, did not influence the magnitude of heat strain that could be tolerated; 3) curves can be developed to estimate exhaustion rates for a given level of physiological strain; and 4) exhaustion was rarely associated with a core temperature up to 38-degrees-C, and it always occurred before a temperature of 40-degrees-C was achieved. These findings are applicable to heat-acclimated individuals performing moderate-intensity exercise under conditions where E(req) approximates or exceeds E(max) and who have high skin temperatures. RP SAWKA, MN (reprint author), USA,ENVIRONM MED RES INST,DIV THERMAL PHYSIOL & MED,KANSAS ST,NATICK,MA 01760, USA. NR 36 TC 115 Z9 119 U1 2 U2 36 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 8750-7587 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD JUL PY 1992 VL 73 IS 1 BP 368 EP 375 PG 8 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA JE703 UT WOS:A1992JE70300051 PM 1506393 ER PT J AU FOX, AM HALLER, WT GETSINGER, KD AF FOX, AM HALLER, WT GETSINGER, KD TI CORRELATION OF BENSULFURON METHYL AND DYE CONCENTRATIONS IN WATER FOLLOWING CONCURRENT APPLICATION SO JOURNAL OF AQUATIC PLANT MANAGEMENT LA English DT Note C1 UNIV FLORIDA,DEPT AGRON,GAINESVILLE,FL 32606. USA,ENGINEER WATERWAYS EXPT STN,ENVIRONM LAB,VICKSBURG,MS 39180. RP FOX, AM (reprint author), UNIV FLORIDA,CTR AQUAT PLANTS,7922 NW 71ST ST,GAINESVILLE,FL 32606, USA. NR 3 TC 5 Z9 5 U1 0 U2 0 PU AQUATIC PLANT MANAGEMENT SOC, INC PI CLERMONT PA PO BOX 121086, CLERMONT, FL 34712-1086 SN 0146-6623 J9 J AQUAT PLANT MANAGE JI J. Aquat. Plant Manage. PD JUL PY 1992 VL 30 BP 73 EP 74 PG 2 WC Plant Sciences; Marine & Freshwater Biology SC Plant Sciences; Marine & Freshwater Biology GA JD735 UT WOS:A1992JD73500006 ER PT J AU KADAKIA, SC KADAKIA, AS SEARGENT, K AF KADAKIA, SC KADAKIA, AS SEARGENT, K TI ENDOSCOPIC REMOVAL OF COLONIC LEIOMYOMA SO JOURNAL OF CLINICAL GASTROENTEROLOGY LA English DT Article DE LEIOMYOMA; COLONOSCOPY; GASTROINTESTINAL TUMOR; ENDOSCOPY ID SMOOTH-MUSCLE TUMORS; DIFFUSE LEIOMYOMATOSIS; ESOPHAGUS; RECTUM; DIAGNOSIS; STOMACH; TRACT AB Most gastrointestinal leiomyomas are found in the stomach, only 3% of them arising in the colon. Surgical resection of the leiomyoma is usually necessary owing to its submucosal location. We describe a patient with a 1.5 cm pedunculated leiomyoma of the colon successfully removed by colonoscopic snare electrocauterization. We believe this to be the first report of a colonic leiomyoma of this size removed endoscopically without complication. We review the literature regarding gastrointestinal leiomyomas with special attention to pedunculated leiomyomas and their endoscopic management. C1 BROOKE ARMY MED CTR,DEPT PATHOL,FT SAM HOUSTON,TX 78234. RP KADAKIA, SC (reprint author), BROOKE ARMY MED CTR,DEPT MED,GASTROENTEROL SERV,FT SAM HOUSTON,TX 78234, USA. NR 26 TC 7 Z9 7 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0192-0790 J9 J CLIN GASTROENTEROL JI J. Clin. Gastroenterol. PD JUL PY 1992 VL 15 IS 1 BP 59 EP 62 DI 10.1097/00004836-199207000-00014 PG 4 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA JB991 UT WOS:A1992JB99100013 PM 1500663 ER PT J AU LEVINE, MM MCEWEN, J LOSONSKY, G REYMANN, M HARARI, I BROWN, JE TAYLOR, DN DONOHUEROLFE, A COHEN, D BENNISH, M LIM, YL ARNON, R AF LEVINE, MM MCEWEN, J LOSONSKY, G REYMANN, M HARARI, I BROWN, JE TAYLOR, DN DONOHUEROLFE, A COHEN, D BENNISH, M LIM, YL ARNON, R TI ANTIBODIES TO SHIGA HOLOTOXIN AND TO 2 SYNTHETIC PEPTIDES OF THE B-SUBUNIT IN SERA OF PATIENTS WITH SHIGELLA-DYSENTERIAE-1 DYSENTERY SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID HEMOLYTIC-UREMIC SYNDROME; LINKED IMMUNOSORBENT-ASSAY; SALMONELLA-TYPHI; ESCHERICHIA-COLI; SHIGELLA DIARRHEA; DISTINCT TOXINS; RHESUS-MONKEYS; CYTO-TOXIN; PATHOGENESIS; DISEASE AB Acute- and convalescent-phase sera from 18 Thai patients and convalescent-phase sera from two Israeli patients and one Bangladeshi patient with Shigella dysenteriae 1 (Shiga) dysentery were tested by enzyme-linked immunosorbent assay to detect antibodies that bind S. dysenteriae lipopolysaccharide (LPS), Ship holotoxin, or two synthetic peptides representing epitopes from the B subunit of Ship toxin. Paired sera from 24 Maryland adults with Shigella flexneri 2a or Shigella sonnei diarrhea served as negative controls. Of the 16 paired Thai serum samples tested for immunoglobulin G LPS antibody, 10 had greater-than-or-equal-to 4-fold rises (the two subjects with the highest convalescent-phase titers exhibited toxin-neutralizing activity); acute-phase specimens from four of the remaining six individuals already had elevated Shiga LPS titers in their acute specimens ranging from 1:800 to 1:12,800. Similarly, convalescent-phase sera from the two Israeli patients and the Bangladeshi patient revealed LPS titers of 1:800 to 1:3,200. In contrast, none of the Maryland volunteers with S. flexneri or S. sonnei diarrhea manifested rises in Shiga anti-LPS (P < 0.00001 versus 10 of 16 Thai patients). Only 4 of the 18 Thai patients had significant rises in antibody to purified Shiga toxin, while one of the two Israeli patients and the one Bangladeshi patient had elevated convalescent-phase titers. None of the sera that reacted with Shiga holotoxin had antibody that bound to the peptides. This report, which describes a search for serum antibodies that bind Shiga toxin in patients with Shiga dysentery, demonstrates such antibodies in only a minority of patients with bacteriologically confirmed disease. During Shiga dysentery, Shiga toxin may be elaborated in such small quantities in vivo that it fails to elicit an immune response in most patients even though it may exert biological effects. In this behavior Shiga toxin resembles tetanus toxin, another potent exotoxin that fails to elicit antitoxic responses in people who recover from clinical tetanus. C1 UNIV MARYLAND,SCH MED,DIV INFECT DIS & TROP PEDIAT,BALTIMORE,MD 21201. WEIZMANN INST SCI,DEPT CHEM IMMUNOL,IL-76100 REHOVOT,ISRAEL. ARMED FORCES RES INST MED SCI,DEPT BACTERIOL,BANGKOK,THAILAND. TUFTS UNIV,SCH MED,DEPT MED,DIV GEOG MED & INFECT DIS,BOSTON,MA 02111. TUFTS UNIV,SCH MED,DEPT PEDIAT,BOSTON,MA 02111. RP LEVINE, MM (reprint author), UNIV MARYLAND,SCH MED,DEPT MED,DIV GEOG MED,CTR VACCINE DEV,BALTIMORE,MD 21201, USA. NR 49 TC 20 Z9 21 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD JUL PY 1992 VL 30 IS 7 BP 1636 EP 1641 PG 6 WC Microbiology SC Microbiology GA HZ759 UT WOS:A1992HZ75900004 PM 1629317 ER PT J AU KAIN, KC BROWN, AE WEBSTER, HK WIRTZ, RA KEYSTONE, JS RODRIGUEZ, MH KINAHAN, J ROWLAND, M LANAR, DE AF KAIN, KC BROWN, AE WEBSTER, HK WIRTZ, RA KEYSTONE, JS RODRIGUEZ, MH KINAHAN, J ROWLAND, M LANAR, DE TI CIRCUMSPOROZOITE GENOTYPING OF GLOBAL ISOLATES OF PLASMODIUM-VIVAX FROM DRIED BLOOD SPECIMENS SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Note ID PROTEIN AB The prevalence and global distribution of two circumsporozoite (CS) genotypes of Plasmodium vivax (VK210 and VK247) were determined by genetic analysis of isolates from 234 malaria-infected patients. Whole blood specimens were collected on filter paper from patients infected with malaria in Thailand, Mexico, Papua New Guinea, Peru, Afghanistan (Pakistan), India, and western Africa and from 50 asymptomatic smear-negative controls. Following extraction of DNA from the filter paper samples, the CS gene was amplified by the polymerase chain reaction and genotyped by using oligoprobes specific for the VK210 and VK247 repeat epitopes. The sensitivity of genotyping from a single blood dot was 95.2%. The VK247 CS genotype was identified in the blood of patients from all seven study areas and was the predominant form present in samples from Thailand (83%) and Papua New Guinea (90%). In contrast, VK247 DNA was present in only 9% of isolates from Mexico. Individuals infected with both genotypes simultaneously were identified in all study areas except Mexico and were particularly common in Thailand (58%) and Papua New Guinea (60%). These findings indicate that the VK247 genotype of P. vivax is widely distributed but that its prevalence varies geographically. In addition, we conclude that use of samples of whole blood on filter paper is a practical and sensitive method for determining the genotypes of large numbers of malaria isolates collected in field settings. C1 ARMED FORCES RES INST MED SCI,DEPT IMMUNOL & BIOCHEM,APO AP 96546,BANGKOK,THAILAND. WALTER REED ARMY MED CTR,DEPT IMMUNOL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT ENTOMOL,WASHINGTON,DC 20307. CTR INVEST PALUDISMO,TAPACHULA 30700,CHIAPAS,MEXICO. MED SANS FRONTIERES ARTSEN,PESHAWAR,PAKISTAN. RP KAIN, KC (reprint author), TORONTO HOSP,DIV INFECT DIS,TROP DIS UNIT,TORONTO M5G 2C4,ONTARIO,CANADA. RI Lanar, David/B-3560-2011 NR 14 TC 50 Z9 52 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD JUL PY 1992 VL 30 IS 7 BP 1863 EP 1866 PG 4 WC Microbiology SC Microbiology GA HZ759 UT WOS:A1992HZ75900042 PM 1629344 ER PT J AU MANN, RW SHIELDS, ED AF MANN, RW SHIELDS, ED TI CAVITATION DEFECTS ON THE LINGUAL RAMUS - A FURTHER EXPRESSION OF STAFNE DEFECT SO JOURNAL OF CRANIOFACIAL GENETICS AND DEVELOPMENTAL BIOLOGY LA English DT Article DE IDIOPATHIC BONE CAVITY; STAFNE DEFECT; MANDIBLE ID MANDIBULAR BONE DEPRESSION AB Seven archaeological examples of 6,700 mandibles examined were found to have developmental cortical defects on the ramus. The defects, unusual in their position, were grossly and radiographically similar to developmental bone cavities (Stafne's) located in the sublingual region. Of the seven ramus defects, all of which were in adult males, six were in Alaskan Eskimos from Kodiak Island (N = 5) and Nelson Island (N = 1), and one was in a native American from Arkansas. Only five adult males from Finland have been reported with similar defects. A statistical examination of the metrics defining mandibular cavitation defects, along with prevalence data, suggest that the seemingly rare findings of ramus defects are an extreme manifestation of the continuum of severity of the Stafne's defect. Bilateral Stafne's defects also represent a severe manifestation. C1 SMITHSONIAN INST,DEPT ANTHROPOL,WASHINGTON,DC 20560. MCGILL UNIV,DEPT ORAL BIOL,MONTREAL H3A 2T5,QUEBEC,CANADA. MCGILL UNIV,CTR HUMAN GENET,MONTREAL H3A 2T5,QUEBEC,CANADA. RP MANN, RW (reprint author), USA,CENT IDENTIFICAT LAB,FT KAMEHAMEHA BLDG 45,HICKAM AFB,HI 96853, USA. NR 12 TC 12 Z9 12 U1 1 U2 1 PU MUNKSGAARD INT PUBL LTD PI COPENHAGEN PA 35 NORRE SOGADE, PO BOX 2148, DK-1016 COPENHAGEN, DENMARK SN 0270-4145 J9 J CRAN GENET DEV BIO JI J. Craniofac. Genet. Dev. Biol. PD JUL-SEP PY 1992 VL 12 IS 3 BP 167 EP 173 PG 7 WC Anatomy & Morphology; Developmental Biology; Genetics & Heredity SC Anatomy & Morphology; Developmental Biology; Genetics & Heredity GA JF943 UT WOS:A1992JF94300006 PM 1517396 ER PT J AU HAYS, JH EIL, C SMALLRIDGE, RC AF HAYS, JH EIL, C SMALLRIDGE, RC TI SODIUM IPODATE INCREASES TRIIODOTHYRONINE ACTION INVIVO SO JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION LA English DT Article DE SODIUM IPODATE; ALPHA-GLYCEROPHOSPHATE DEHYDROGENASE ACTIVITY; INVIVO ID ANGIOTENSIN-CONVERTING ENZYME; THYROID-HORMONES; CONTRAST AGENTS; IOPANOIC ACID; L-THYROXINE; PITUITARY; RATS; BINDING; HYPERTHYROIDISM; HYPOTHYROIDISM AB Sodium ipodate (IPO) has been shown to bind nuclear T3 receptors (NT3R) in vitro, but previous studies have conflicted in regard to demonstration of this interaction in vivo. We sought evidence for IPO-NT3R binding in vivo by giving large doses of IPO to thyroidectomized (TDX) rats replaced with low doses of T3. We predicted that IPO-NT3R binding would inhibit T3 induced increases in mitochondrial alpha glycerophosphate dehydrogenase activity (alpha-GPDH) in kidney, heart and liver. Three groups of ten euthyroid rats each received 13 daily injections of vehicle, or 6 or 12 mg/100 g body weight of IPO, respectively. Both doses of IPO resulted in decreases in serum T3 and increases in serum TSH. Liver and kidney alpha-GPDH, however, were decreased only in the group receiving 6 mg IPO. In addition, three groups of 30 TDX rats were implanted with osmotic minipumps that contained T3 in the following concentrations: 33, 69 and 96 ng/ul. Ten rats in each group received 13 daily injections of vehicle, or IPO (vide supra). The alpha-GPDH responses were complex in that there was significant interaction between T3 and IPO effects in the kidney (AxB F ratio 5.13, p<0.001) and liver (AxB F ratio 2.85, p<0.05). The major finding, however, was that alpha-GPDH was not significantly reduced by IPO in any T3 replaced group. Rather, in all three organs, alpha GPDH was significantly increased above that produced by T3 alone by at least one combination of IPO and T3. Changes in serum TSH also suggested that IPO could enhance T3 effects. We conclude that IPO-NT3R binding is not a prominent mechanism via which the drug attenuates T3 effects in vivo. The data suggest that IPO may enhance T3 effects at the cellular level and that this enhancement may not be reflected by routinely monitored serum TSH. The latter observation may have clinical importance. C1 WALTER REED ARMY MED CTR,DIV MED,CLIN PHYSIOL BRANCH,WASHINGTON,DC 20307. NR 23 TC 0 Z9 0 U1 0 U2 0 PU EDITRICE KURTIS S R L PI MILANO PA VIA LUIGI ZOJA, 30-20153 MILANO, ITALY SN 0391-4097 J9 J ENDOCRINOL INVEST JI J. Endocrinol. Invest. PD JUL-AUG PY 1992 VL 15 IS 7 BP 507 EP 512 PG 6 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA JL877 UT WOS:A1992JL87700005 PM 1332995 ER PT J AU SCOTT, AC VIRE, DE SWANSON, R AF SCOTT, AC VIRE, DE SWANSON, R TI AN EVALUATION OF THE THERMAFIL ENDODONTIC OBTURATION TECHNIQUE SO JOURNAL OF ENDODONTICS LA English DT Article ID THERMOPLASTICIZED GUTTA-PERCHA; DYE PENETRATION; APICAL SEAL; PLACEMENT AB The purpose of this study was to evaluate the Thermafil endodontic obturation technique and to compare it with laterally condensed gutta-percha. Thirty-seven maxillary central incisors were similarly prepared and divided into groups. Seventeen were obturated with Thermafil and 17 with lateral condensation. Three served as controls. After vacuum staining, all teeth were cleared and apical dye penetration was evaluated by two independent observers. Average leakage values were 0.24 mm and 1.32 mm for Thermafil and 0.47 mm and 1.18 mm for lateral condensation. There was no significant difference between the techniques, although a difference between evaluators was noted. Final results point to the relative subjectivity of in vitro leakage studies. When comparing the obturation times of both techniques, the Thermafil technique averaged 2 min 56 s while lateral condensation took 3 min 26 s. Statistical analysis showed no significant difference in obturation times. RP SCOTT, AC (reprint author), USA CORP,ADV EDUC GEN DENT PROGRAM,FT BRAGG,NC, USA. NR 17 TC 20 Z9 21 U1 0 U2 1 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0099-2399 J9 J ENDODONT JI J. Endod. PD JUL PY 1992 VL 18 IS 7 BP 340 EP 343 DI 10.1016/S0099-2399(06)80485-1 PG 4 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA JB421 UT WOS:A1992JB42100007 PM 1402597 ER PT J AU MELLEN, PF WEEDN, VW KAO, G AF MELLEN, PF WEEDN, VW KAO, G TI ELECTROCUTION - A REVIEW OF 155 CASES WITH EMPHASIS ON HUMAN-FACTORS SO JOURNAL OF FORENSIC SCIENCES LA English DT Article; Proceedings Paper CT 43RD ANNUAL MEETING OF THE AMERICAN ACADEMY OF FORENSIC SCIENCES CY FEB 18-24, 1991 CL ANAHEIM, CA SP AMER ACAD FORENS SCI DE PATHOLOGY AND BIOLOGY ELECTROCUTION; LIGHTNING; ACCIDENTS; HUMAN FACTOR; ALCOHOL ID INJURIES AB A total of 155 cases of electrocution were investigated to determine the role of human factors, such as carelessness and intoxication, as contributions. The cases were retrieved by computer coding from the repository of the Armed Forces Institute of Pathology, covering the period 1955-1988. The cases are predominantly of military origin. Cases were divided into low-voltage electrocution (N = 47), high-voltage electrocution (N = 79), lightning strikes (N = 16), and unclassified (N = 13). For each group, data is presented on the circumstances of the incident and the pathologic and toxicologic findings. Blatant carelessness, misuse or improper maintenance of equipment, and intoxication are analyzed as contributory factors. C1 ARMED FORCES INST PATHOL,DEPT DERMATOPATHOL,WASHINGTON,DC 20306. WALTER REED ARMY MED CTR,DEPT PATHOL,WASHINGTON,DC 20307. ARMED FORCES INST PATHOL,OFF ARMED FORCES MED EXAMINER,WASHINGTON,DC 20306. NR 19 TC 23 Z9 24 U1 0 U2 4 PU AMER SOC TESTING MATERIALS PI W CONSHOHOCKEN PA 100 BARR HARBOR DR, W CONSHOHOCKEN, PA 19428-2959 SN 0022-1198 J9 J FORENSIC SCI JI J. Forensic Sci. PD JUL PY 1992 VL 37 IS 4 BP 1016 EP 1022 PG 7 WC Medicine, Legal SC Legal Medicine GA JY405 UT WOS:A1992JY40500011 PM 1506824 ER PT J AU GILBERT, PA AF GILBERT, PA TI RAPID WATER-CONTENT BY COMPUTER-CONTROLLED MICROWAVE DRYING - CLOSURE SO JOURNAL OF GEOTECHNICAL ENGINEERING-ASCE LA English DT Discussion RP GILBERT, PA (reprint author), USA,WATERWAYS EXPT STN,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 1 TC 1 Z9 1 U1 0 U2 0 PU ASCE-AMER SOC CIVIL ENGINEERS PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-9410 J9 J GEOTECH ENG-ASCE JI J. Geotech. Eng.-ASCE PD JUL PY 1992 VL 118 IS 7 BP 1131 EP 1133 DI 10.1061/(ASCE)0733-9410(1992)118:7(1131.2) PG 3 WC Engineering, Civil; Geosciences, Multidisciplinary SC Engineering; Geology GA JA558 UT WOS:A1992JA55800015 ER PT J AU WOLFF, TF CONROY, PJ AF WOLFF, TF CONROY, PJ TI IMPROVED DESIGN PROCEDURES FOR VERTICALLY LOADED H-PILES IN SAND - DISCUSSION SO JOURNAL OF GEOTECHNICAL ENGINEERING-ASCE LA English DT Discussion C1 USA,CORPS ENGRS,ST LOUIS,MO 63103. RP WOLFF, TF (reprint author), MICHIGAN STATE UNIV,DEPT CIVIL & ENVIRONM ENGN,E LANSING,MI 48824, USA. NR 14 TC 0 Z9 0 U1 0 U2 0 PU ASCE-AMER SOC CIVIL ENGINEERS PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-9410 J9 J GEOTECH ENG-ASCE JI J. Geotech. Eng.-ASCE PD JUL PY 1992 VL 118 IS 7 BP 1133 EP 1136 DI 10.1061/(ASCE)0733-9410(1992)118:7(1133.2) PG 4 WC Engineering, Civil; Geosciences, Multidisciplinary SC Engineering; Geology GA JA558 UT WOS:A1992JA55800016 ER PT J AU MURPHY, CH AF MURPHY, CH TI SYMPTOM OF PAYLOAD-INDUCED FLIGHT INSTABILITY SO JOURNAL OF GUIDANCE CONTROL AND DYNAMICS LA English DT Note RP MURPHY, CH (reprint author), USA,BALLIST RES LAB,DIV LAUNCH & FLIGHT,SLCBR LF,ABERDEEN PROVING GROUND,MD 21005, USA. NR 13 TC 0 Z9 0 U1 0 U2 0 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091 SN 0731-5090 J9 J GUID CONTROL DYNAM JI J. Guid. Control Dyn. PD JUL-AUG PY 1992 VL 15 IS 4 BP 1038 EP 1040 DI 10.2514/3.20942 PG 3 WC Engineering, Aerospace; Instruments & Instrumentation SC Engineering; Instruments & Instrumentation GA JE878 UT WOS:A1992JE87800032 ER PT J AU GLIGIC, A DIMKOVIC, N XIAO, SY BUCKLE, GJ JOVANOVIC, D VELIMIROVIC, D STOJANOVIC, R OBRADOVIC, M DIGLISIC, G MICIC, J ASHER, DM LEDUC, JW YANAGIHARA, R GAJDUSEK, DC AF GLIGIC, A DIMKOVIC, N XIAO, SY BUCKLE, GJ JOVANOVIC, D VELIMIROVIC, D STOJANOVIC, R OBRADOVIC, M DIGLISIC, G MICIC, J ASHER, DM LEDUC, JW YANAGIHARA, R GAJDUSEK, DC TI BELGRADE VIRUS - A NEW HANTAVIRUS CAUSING SEVERE HEMORRHAGIC-FEVER WITH RENAL SYNDROME IN YUGOSLAVIA SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID NEPHROPATHIA EPIDEMICA; ETIOLOGIC AGENT; DIAGNOSIS; ANTIBODY; ANTIGEN; VOLES AB Two biologically and genetically distinct hantaviruses were isolated from blood and urine specimens collected from four Yugoslavian patients with clinically severe hemorrhagic fever with renal syndrome (HFRS). Viral isolates from three patients, designated strains Belgrade 1-3, were distinct from Hantaan, Seoul, Puumala, and Prospect Hill viruses as determined by plaque-reduction neutralization tests and restriction analysis of enzymatically amplified M-segment fragments. The fourth isolate, called Kraljevo, was indistinguishable from Hantaan virus. Strains Belgrade 1 and 2, like the Kraljevo strain, caused a fatal meningoencephalitis in newborn mice inoculated with 100 pfu of virus intracerebrally and intraperitoneally. Strain Belgrade 3 was much less neurovirulent, requiring 30,000 pfu of virus to cause fatal disease in mice. These data indicate that two distinct hantaviruses, one of which constitutes a new serotype, cause clinically severe HFRS in Yugoslavia. C1 NINCDS,CENT NERVOUS SYST STUDIES LAB,BLDG 36,RM 5B-21,BETHESDA,MD 20892. INST IMMUNOL & VIROL,BELGRADE,YUGOSLAVIA. INST RENAL DIS,BELGRADE,YUGOSLAVIA. CLIN NEPHROL,CTR ACUTE CARE,BELGRADE,YUGOSLAVIA. MIL MED ACAD,BELGRADE,YUGOSLAVIA. USA,MED RES INST INFECT DIS,DIV DIS ASSESSMENT,FREDERICK,MD 21701. NR 36 TC 71 Z9 73 U1 1 U2 1 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD JUL PY 1992 VL 166 IS 1 BP 113 EP 120 PG 8 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA HZ746 UT WOS:A1992HZ74600017 PM 1351508 ER PT J AU SETHABUTR, O BROWN, AE PANYIM, S KAIN, KC WEBSTER, HK ECHEVERRIA, P AF SETHABUTR, O BROWN, AE PANYIM, S KAIN, KC WEBSTER, HK ECHEVERRIA, P TI DETECTION OF PLASMODIUM-FALCIPARUM BY POLYMERASE CHAIN-REACTION IN A FIELD-STUDY SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID DNA PROBE AB Detection of Plasmodium falciparum by polymerase chain reaction (PCR) was evaluated in 33 P. falciparum-infected patients with two different amplification systems over 5-7 days of curative treatment. In the K1-14 system, a P. falciparum DNA fragment of 206 bp was detected, and in the circumsporozoite (CS) system, a fragment of 800 bp was detected. The K1-14 and CS systems identified 95% and 93%, respectively, of 103 microscopically identified specimens; both systems detected as few as 11 parasites/mu-l among these specimens. Specimens from 20 smear- and history-negative controls were all negative by both PCR systems. The K1-14 and CS systems detected P. falciparum DNA in 53% and 20%, respectively, of blood films collected on the first day and 3% and 0 of the blood films collected on the fourth day after reversion to microscopic negative. The simultaneous use of two independent PCR systems to monitor patients during curative treatment of P. falciparum infections convincingly demonstrated that P. falciparum DNA was present transiently in the blood of infected patients at a time when the parasite could no longer be detected microscopically. C1 ARMED FORCES RES INST MED SCI,DEPT BACTERIOL IMMUNOL & MOLEC GENET,APO AP 96546,BANGKOK,THAILAND. MAHIDOL UNIV,FAC SCI,DEPT BIOCHEM,BANGKOK 10700,THAILAND. MAHIDOL UNIV,CTR MOLEC GENET GENET ENGN,BANGKOK 10700,THAILAND. WALTER REED ARMY MED CTR,DEPT IMMUNOL,WASHINGTON,DC 20307. RI Panyim, Sakol/B-6024-2008 NR 12 TC 60 Z9 62 U1 0 U2 1 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD JUL PY 1992 VL 166 IS 1 BP 145 EP 148 PG 4 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA HZ746 UT WOS:A1992HZ74600021 PM 1607686 ER PT J AU VANDEVERG, LL HERRINGTON, DA BOSLEGO, J LINDBERG, AA LEVINE, MM AF VANDEVERG, LL HERRINGTON, DA BOSLEGO, J LINDBERG, AA LEVINE, MM TI AGE-SPECIFIC PREVALENCE OF SERUM ANTIBODIES TO THE INVASION PLASMID AND LIPOPOLYSACCHARIDE ANTIGENS OF SHIGELLA SPECIES IN CHILEAN AND NORTH-AMERICAN POPULATIONS SO JOURNAL OF INFECTIOUS DISEASES LA English DT Note ID ESCHERICHIA-COLI; PROTEINS; FLEXNERI; SONNEI AB Shigella species have virulence plasmids that encode outer membrane proteins (invasion plasmid antigens, Ipa) associated with pathogenicity. Western blots were used to detect antibodies to Ipa in sera from 390 Chilean children, and these responses were compared with those of a US population of infants and adults. Antibodies to lipopolysaccharide (LPS) of Plesiomonas shigelloides and Shigella flexneri 2a were measured by ELISA. Among the Chileans, there was an age-related acquisition of Ipa antibodies, with 28% of 1-year-olds and 100% of children greater-than-or-equal-to 10 years showing positive responses. In contrast, none of the US infants and only 38% of the adults had antibodies to Ipa. Levels of LPS antibodies were also found to increase in an age-related manner among the Chileans. These results corroborate findings of previous epidemiologic studies which show that Shigella infections are endemic in Chile, as in other developing countries. The measurement of Ipa and LPS antibodies is a useful seroepidemiologic tool for investigating previous exposure to Shigella species in populations. C1 UNIV MARYLAND,SCH MED,CTR VACCINE DEV,10 S PINE ST,BALTIMORE,MD 21201. WALTER REED ARMY MED CTR,DEPT BACTERIAL DIS,WASHINGTON,DC 20307. KAROLINSKA INST,S-14186 HUDDINGE,SWEDEN. NR 15 TC 29 Z9 30 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD JUL PY 1992 VL 166 IS 1 BP 158 EP 161 PG 4 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA HZ746 UT WOS:A1992HZ74600024 PM 1607690 ER PT J AU DHAWAN, S VARGO, M MELTZER, MS AF DHAWAN, S VARGO, M MELTZER, MS TI INTERACTIONS BETWEEN HIV-INFECTED MONOCYTES AND THE EXTRACELLULAR-MATRIX - INCREASED CAPACITY OF HIV-INFECTED MONOCYTES TO ADHERE TO AND SPREAD ON EXTRACELLULAR-MATRIX ASSOCIATED WITH CHANGES IN EXTENT OF VIRUS-REPLICATION AND CYTOPATHIC EFFECTS IN INFECTED-CELLS SO JOURNAL OF LEUKOCYTE BIOLOGY LA English DT Article DE EXTRACELLULAR MATRIX; BASEMENT MEMBRANE; HIV; INTEGRIN ID HUMAN-IMMUNODEFICIENCY-VIRUS; PERIPHERAL-BLOOD MONOCYTES; GENE-EXPRESSION; LYMPHOCYTES-T; MONONUCLEAR PHAGOCYTES; MESSENGER-RNA; AIDS VIRUS; MACROPHAGES; LIPOPOLYSACCHARIDE; ENCEPHALOPATHY AB Monocytes express cell surface receptors for extracellular matrix (ECM) proteins of basement membranes. These receptors are engaged during extravasation of cells through capillary endothelium into tissue. The number of human immunodeficiency virus (HIV)infected monocytes that adhered to ECM over 2 h was threefold higher than that of uninfected control cells. This difference was ECM specific and was not observed with a bovine serum albumin substrate. Enhanced adhesion to ECM was evident in monocytes by 4 days after HIV infection and increased through 10 days. Monocytes exposed to a T cell-tropic HIV strain that binds to but does not replicate in monocytes showed no changes in adherence to ECM. Thus, productive infection of monocytes by HIV induces a significant increase in the capacity of these cells to interact with ECM. Enhanced adhesion of HIV-infected monocytes to ECM was associated with increased spreading: at 12 h, sixfold more HIV-infected monocytes were spread on ECM than were uninfected control cells. Cell processes of HIV-infected monocytes formed a complex network on ECM: many of these cells expressed HIV proteins as detected by indirect immunofluorescence. HIV-associated cytopathic effects and levels of virion-associated reverse transcriptase activity depended on the substrate to which monocytes were attached. Virus replication and cytopathic effects in monocytes adhered to ECM, fibronectin, or plastic alone were comparable. In contrast, HIV-infected monocytes attached to laminin showed a significant increase in virus replication and in extent of cytopathic effects through 2 weeks after infection. The lowest levels of HIV replication and cytopathic effects were in monocytes attached to collagen IV. Interactions between monocytes and ECM profoundly affect the manner in which these cells control HIV infection: HIV infection changes the capacity of infected monocytes to attach and spread on ECM; attachment to ECM alters the extent of virus replication in infected cells. RP DHAWAN, S (reprint author), WALTER REED ARMY MED CTR,DEPT CELLULAR IMMUNOL,DIV COMMUNICABLE DIS,9620 MED CTR DR,SUITE 200,ROCKVILLE,MD 20850, USA. NR 34 TC 19 Z9 19 U1 0 U2 2 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0741-5400 J9 J LEUKOCYTE BIOL JI J. Leukoc. Biol. PD JUL PY 1992 VL 52 IS 1 BP 62 EP 69 PG 8 WC Cell Biology; Hematology; Immunology SC Cell Biology; Hematology; Immunology GA JQ368 UT WOS:A1992JQ36800009 PM 1640176 ER PT J AU SOLBERG, VB NEIDHARDT, K SARDELIS, MR HOFFMANN, FJ STEVENSON, R BOOBAR, LR HARLAN, HJ AF SOLBERG, VB NEIDHARDT, K SARDELIS, MR HOFFMANN, FJ STEVENSON, R BOOBAR, LR HARLAN, HJ TI FIELD-EVALUATION OF 2 FORMULATIONS OF CYFLUTHRIN FOR CONTROL OF IXODES-DAMMINI AND AMBLYOMMA-AMERICANUM (ACARI, IXODIDAE) SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE ACARINA; CYFLUTHRIN; IXODES-DAMMINI; AMBLYOMMA-AMERICANUM ID LYME-DISEASE; AERIAL APPLICATION; DIAZINON GRANULES; NEW-JERSEY; DEER AB Liquid or granular cyfluthrin was applied in the spring and fall to different test plots at a rate of 0.41 (AI) kg/ha to control Ixodes dammini Spielman, Clifford, Piesman & Corwin and Amblyomma americanum (L.). Spring application of liquid cyfluthrin showed the most significant decreases of both species. I. dammini nymphs were reduced 97% at 10 d, 100% at 2 mo, and 100% at 1 yr; and A. americanum adults and nymphs were reduced 91-93% at 10 d and 100% at 2 mo posttreatment. Granular cyfluthrin applied in the spring gave 97 and 87% control of nymphal I. dammini 10 d and 2 mo posttreatment, respectively. RP SOLBERG, VB (reprint author), USA,BIOMED RES & DEV LAB,FORT DETRICK,FREDERICK,MD 21702, USA. NR 18 TC 33 Z9 33 U1 0 U2 3 PU ENTOMOL SOC AMER PI LANHAM PA 9301 ANNAPOLIS RD, LANHAM, MD 20706 SN 0022-2585 J9 J MED ENTOMOL JI J. Med. Entomol. PD JUL PY 1992 VL 29 IS 4 BP 634 EP 638 PG 5 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA JB992 UT WOS:A1992JB99200010 PM 1495073 ER PT J AU KARDATZKE, JT NEIDHARDT, K DZUBAN, DP SANCHEZ, JL AZAD, AF AF KARDATZKE, JT NEIDHARDT, K DZUBAN, DP SANCHEZ, JL AZAD, AF TI CLUSTER OF TICK-BORNE INFECTIONS AT FORT CHAFFEE, ARKANSAS - RICKETTSIAE AND BORRELIA-BURGDORFERI IN IXODID TICKS SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE ACARI; EHRLICHIAE; RICKETTSIA; LYME DISEASE SPIROCHETES AB Human intrusion into pristine habitats increases the likelihood of acquiring infectious agents from potentially infective ticks. As part of a larger human serological investigation into tick-borne illnesses, 3,000 ixodid ticks were collected during May, August, and November 1990 at Fort Chaffee, Arkansas. Ticks were examined to determine whether they harbor rickettsiae, ehrlichiae, and Borrelia burgdorferi, and to assess relationship to human exposure to tick-borne infections at Fort Chaffee, Ark. The overall tick infection rates with SFG rickettsiae, B. burgdorferi, and ehrlichiae were 4.8, 0.1, and 0.3%, respectively. C1 UNIV MARYLAND,DEPT MICROBIOL & IMMUNOL,BALTIMORE,MD 21201. WALTER REED ARMY MED CTR,DIV PREVENT MED,WASHINGTON,DC 20307. RP KARDATZKE, JT (reprint author), USA ENVIRONM HYG ACT N,FT GEORGE G MEADE,MD 20755, USA. FU NIAID NIH HHS [AI-17828] NR 15 TC 22 Z9 23 U1 0 U2 0 PU ENTOMOL SOC AMER PI LANHAM PA 9301 ANNAPOLIS RD, LANHAM, MD 20706 SN 0022-2585 J9 J MED ENTOMOL JI J. Med. Entomol. PD JUL PY 1992 VL 29 IS 4 BP 669 EP 672 PG 4 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA JB992 UT WOS:A1992JB99200015 PM 1495077 ER PT J AU SOLBERG, VB ARNOLD, MF BOOBAR, LR ROSENBLATT, DH AF SOLBERG, VB ARNOLD, MF BOOBAR, LR ROSENBLATT, DH TI SONIC FLOW REGULATOR FOR METERING PRESSURIZED CO2 GAS SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE CARBON DIOXIDE CYLINDER; GAS REGULATOR; FLOWMETER ID IXODIDAE; CATCHES; ACARINA; TRAPS AB A sonic flow regulator for metering pressurized CO2 gas is described. Flow rates of 5,025, 700, and 400 ml/min were obtained with orifice sizes of 0.53-, 0.32-, and 0.20-mm inner diameter, respectively. This small, rugged regulator is an economical alternative to diaphragm-type regulators. RP SOLBERG, VB (reprint author), USA,BIOMED RES & DEV LAB,FORT DETRICK,FREDERICK,MD 21702, USA. NR 7 TC 0 Z9 0 U1 0 U2 0 PU ENTOMOL SOC AMER PI LANHAM PA 9301 ANNAPOLIS RD, LANHAM, MD 20706 SN 0022-2585 J9 J MED ENTOMOL JI J. Med. Entomol. PD JUL PY 1992 VL 29 IS 4 BP 687 EP 689 PG 3 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA JB992 UT WOS:A1992JB99200018 ER PT J AU SETHABUTR, O HANCHALAY, S LEXOMBOON, U BISHOP, RF HOLMES, IH ECHEVERRIA, P AF SETHABUTR, O HANCHALAY, S LEXOMBOON, U BISHOP, RF HOLMES, IH ECHEVERRIA, P TI TYPING OF HUMAN GROUP-A ROTAVIRUS WITH ALKALINE PHOSPHATASE-LABELED OLIGONUCLEOTIDE PROBES SO JOURNAL OF MEDICAL VIROLOGY LA English DT Article DE OLIGONUCLEOTIDE PROBES; HUMAN ROTAVIRUS; MONOCLONAL ENZYME IMMUNOASSAY ID MONOCLONAL-ANTIBODIES; NUCLEIC-ACID; SEROTYPE; VP7 AB Rotavirus (RV) in stools of children <1 year of age with diarrhea in Bangkok in 1989 were serotyped by monoclonal enzyme immunoassay (MEIA). RNA extracted from these specimens was tested for hybridization with alkaline phosphatase (AP) and P-32-labeled oligonucleotides constructed from the nucleotide sequences of VP7 of human G types 1 (HuG1Ac), 2 (HuG2Ac), 3 (HuG3Ac), and 4 (HuG4Ac). Of 148 specimens that contained RV, 72% (106/148) hybridized with RV G type specific AP-labeled oligonucleotides compared to 47% (70/148) that were serotyped by MEIA (P < 0.001). Of 68 specimens that contained only one VP7 serotype (G-type), as identified by MEIA, 94% (16/17) of G1, 90% (27/30) of G2, 57% (4/7) of G3, and 36% (5/14) of G4 RV hybridized with the AP-labeled HuG1Ac, HuG2Ac, HuG3Ac, and HuG4Ac oligonucleotides, respectively. The probes for G1, 2, 3, and 4 RV were specific for each G type. The results of hybridizing specimens with P-32- and AP-labeled oligonucleotides were similar. After transcription and amplification of cDNA of gene 9, AP-labeled RV G type specific oligonucleotides hybridized with 90% (134/148) of RV specimens. The high sensitivity of these nonimmunological techniques could be of value in identifying G types of RV during vaccine trials. C1 ARMED FORCES RES INST MED SCI,RAJANITI RD,BANGKOK 10400,THAILAND. ROYAL CHILDRENS HOSP,DEPT GASTROENTEROL,PARKVILLE,VIC 3052,AUSTRALIA. UNIV MELBOURNE,DEPT MICROBIOL,PARKVILLE,VIC 3052,AUSTRALIA. CHILDRENS HOSP,BANGKOK,THAILAND. NR 22 TC 10 Z9 10 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0146-6615 J9 J MED VIROL JI J. Med. Virol. PD JUL PY 1992 VL 37 IS 3 BP 192 EP 196 DI 10.1002/jmv.1890370308 PG 5 WC Virology SC Virology GA JC619 UT WOS:A1992JC61900007 PM 1331307 ER PT J AU EPSTEIN, RM AF EPSTEIN, RM TI PATTERNS OF CHANGE AND CONTINUITY IN 19TH-CENTURY WARFARE SO JOURNAL OF MILITARY HISTORY LA English DT Article RP EPSTEIN, RM (reprint author), SCH ADVANCED MILITARY STUDIES,USA COMMAND & GENERAL STAFF COLL,FT LEAVENWORTH,KS, USA. NR 17 TC 0 Z9 0 U1 0 U2 0 PU SOC MILITARY HISTORY PI LEXINGTON PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA 24450-1600 SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD JUL PY 1992 VL 56 IS 3 BP 375 EP 388 DI 10.2307/1985968 PG 14 WC History SC History GA JA533 UT WOS:A1992JA53300001 ER PT J AU WALANTAS, SD PUGSLEY, K AF WALANTAS, SD PUGSLEY, K TI TUNE IN TO EXERCISE AND NUTRITION SO JOURNAL OF NUTRITION EDUCATION LA English DT Note C1 KELLER ARMY COMMUNITY HOSP,COMMUNITY HLTH CARE SERV,W POINT,NY 10996. NR 0 TC 0 Z9 0 U1 0 U2 0 PU DECKER PERIODICALS INC PI HAMILTON PA 4 HUGHSON STREET SOUTH PO BOX 620, LCD 1, HAMILTON ON L8N 3K7, CANADA SN 0022-3182 J9 J NUTR EDUC JI J. Nutr. Educ. PD JUL-AUG PY 1992 VL 24 IS 4 BP C206 EP C206 PG 1 WC Education, Scientific Disciplines; Nutrition & Dietetics SC Education & Educational Research; Nutrition & Dietetics GA JL258 UT WOS:A1992JL25800011 ER PT J AU FAMINI, GR PENSKI, CA AF FAMINI, GR PENSKI, CA TI USING THEORETICAL DESCRIPTORS IN QUANTITATIVE STRUCTURE-ACTIVITY-RELATIONSHIPS - SOME PHYSICOCHEMICAL PROPERTIES SO JOURNAL OF PHYSICAL ORGANIC CHEMISTRY LA English DT Article ID SOLVATION ENERGY RELATIONSHIPS; ORGANIC-COMPOUNDS; ACTIVATED CARBON; PARAMETERS; MECHANISM; MOLECULES; SOLVENTS; PHASE AB The application of computational techniques to biology, chemistry and physics is growing rapidly. Quantitative structure-activity relationships (QSAR) have been used widely to relate biological activities and physicochemical properties to molecular structural features. A difficulty in this approach has been non-uniformity of parameter sets resulting in the inability to examine contributions across properties and data sets. Linear solvation energy relationships (LSER) developed by Kamlet and Taft successfully utilize a single set of parameters to correlate a wide range of biological, chemical and physical properties. The empirical LSER solvatochromic parameters have been replaced with theoretically determined parameters to permit greater ease in a priori property prediction. These TLSER descriptors have given good correlations and interpretations for some biological activities. This paper discusses the application of these descriptors to six physicochemical properties involving equilibria, kinetics and spectra. The results show good correlation and physical interpretation. C1 LA SIERRA UNIV,DEPT CHEM,RIVERSIDE,CA 92515. RP FAMINI, GR (reprint author), USA,CTR CHEM RES DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010, USA. NR 38 TC 121 Z9 130 U1 2 U2 10 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0894-3230 J9 J PHYS ORG CHEM JI J. Phys. Org. Chem. PD JUL PY 1992 VL 5 IS 7 BP 395 EP 408 DI 10.1002/poc.610050704 PG 14 WC Chemistry, Organic; Chemistry, Physical SC Chemistry GA JE420 UT WOS:A1992JE42000003 ER PT J AU CAMPBELL, TM NAGY, WW AF CAMPBELL, TM NAGY, WW TI A VINYL POLYSILOXANE DIE USED TO MAKE INTERIM RESTORATIONS SO JOURNAL OF PROSTHETIC DENTISTRY LA English DT Article ID ACCURACY AB A die made of vinyl polysiloxane is a great aid for making interim restorations and for establishing correct gingival contours for finer restorations. This article describes the rationale and procedures for such a procedure. C1 USA,DENT ACTIV,FT SAM HOUSTON,TX 78234. NR 6 TC 3 Z9 3 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0022-3913 J9 J PROSTHET DENT JI J. Prosthet. Dent. PD JUL PY 1992 VL 68 IS 1 BP 201 EP 203 DI 10.1016/0022-3913(92)90305-T PG 3 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA JC173 UT WOS:A1992JC17300033 PM 1403909 ER PT J AU ANSLEY, RJ PRICE, DL DOWHOWER, SL CARLSON, DH AF ANSLEY, RJ PRICE, DL DOWHOWER, SL CARLSON, DH TI SEASONAL TRENDS IN LEAF-AREA OF HONEY MESQUITE TREES - DETERMINATION USING IMAGE-ANALYSIS SO JOURNAL OF RANGE MANAGEMENT LA English DT Article DE BIOMASS; FOLIAGE; GROWTH AND DEVELOPMENT; CANOPY; ABSCISSION; PHREATOPHYTE ID PHREATOPHYTE PROSOPIS-GLANDULOSA; WATER RELATIONS; SONORAN DESERT; VAR TORREYANA; CALIFORNIA; DYNAMICS; BIOMASS AB Black-and-white photographs were used to estimate seasonal trends in whole plant leaf area of honey mesquite (Prosopis glandulosa var. glandulosa Torr.) trees occurring on a site with limited subsurface water. Height and canopy width of the trees ranged from 1 to 5 m and 1 to 7 m, respectively. Images consisted of profile-view angles of trees occurring on flat terrain. Four image variables, height, width, canopy profile perimeter length, and canopy profile area were obtained from the photographs and used to predict leaf area of unharvested trees. Predictive equations were based on adjacent trees which were photographed and harvested for actual leaf area determination. Canopy profile area was evaluated as the most accurate image variable for predicting leaf area. Whole plant leaf area of unharvested trees varied within and between growing seasons and was dependent on precipitation patterns. During the 1987 growing season, leaf area declined significantly by 14.6% from 17.1 m2 (1 leaf surface) in May to 14.6 m2 in August, in conjunction with a mid-summer dry period. Leaf area increased in September 1987 in response to late-summer precipitation. Leaf area was less in the spring of 1988 than the spring of 1987 because of lower precipitation during the winter prior to the 1988 than the 1987 growing season. Leaf area did not decline significantly from spring to mid-summer in 1988 as it did the previous year because of atypically high precipitation in July 1988. Leaf area did not increase in September of 1988 as it did in 1987 because of lack of late-season rains in 1988. These results suggest mesquite on this study site used partial leaf shedding to augment drought resistance. C1 TEXAS A&M UNIV SYST,DEPT RANGELAND ECOL & MANAGEMENT,COLLEGE STN,TX 77843. USA,CONSTRUCT ENGN RES LAB,CHAMPAIGN,IL 61826. RP ANSLEY, RJ (reprint author), TEXAS AGR EXPTL STN,PO 1658,VERNON,TX 76384, USA. NR 31 TC 14 Z9 14 U1 0 U2 1 PU SOC RANGE MANAGEMENT PI DENVER PA 1839 YORK ST, DENVER, CO 80206 SN 0022-409X J9 J RANGE MANAGE JI J. Range Manage. PD JUL PY 1992 VL 45 IS 4 BP 339 EP 344 DI 10.2307/4003079 PG 6 WC Agriculture, Dairy & Animal Science; Ecology SC Agriculture; Environmental Sciences & Ecology GA JD608 UT WOS:A1992JD60800003 ER PT J AU FARLEY, GL SMITH, BT MAIDEN, J AF FARLEY, GL SMITH, BT MAIDEN, J TI COMPRESSION RESPONSE OF THICK LAYER COMPOSITE LAMINATES WITH THROUGH-THE-THICKNESS REINFORCEMENT SO JOURNAL OF REINFORCED PLASTICS AND COMPOSITES LA English DT Article AB Compression and compression-after-impact (CAI) tests were conducted on seven different AS4-3501-6 [0/90] 0.64-cm thick composite laminates. Four of the seven laminates had through-the-thickness (TTT) reinforcement fibers. Two TTT reinforcement methods, stitching and integral weaving, and two reinforcement fibers, Kevlar and carbon, were used. The remaining three laminates were made without TTT reinforcements and were tested to establish a baseline for comparison with the laminates having TTT reinforcement. Six of the seven laminates consisted of nine thick layers whereas the seventh material was composed of 46 thin plies. The use of thick-layer material has the potential for reducing structural part cost because of the reduced part count (layers of material). The compression strengths of the TTT reinforced laminates were approximately one half those of the materials without TTT reinforcements. However, the CAI strengths of the TTT reinforced materials were approximately twice those of materials without TTT reinforcements. The improvement in CAI strength is due to an increase in interlaminar strength produced by the TTT reinforcement. Stitched laminates had slightly higher compression and CAI strengths than the integrally woven laminates. C1 COLL WILLIAM & MARY,WILLIAMSBURG,VA 23185. TEXT TECHNOL INC,HATBORO,PA 19040. RP FARLEY, GL (reprint author), NASA,LANGLEY RES CTR,USA,AEROSTRUCT DIRECTORATE,AVSCOM,HAMPTON,VA 23665, USA. NR 35 TC 44 Z9 46 U1 1 U2 2 PU TECHNOMIC PUBL CO INC PI LANCASTER PA 851 NEW HOLLAND AVE, BOX 3535, LANCASTER, PA 17604 SN 0731-6844 J9 J REINF PLAST COMP JI J. Reinf. Plast. Compos. PD JUL PY 1992 VL 11 IS 7 BP 787 EP 810 DI 10.1177/073168449201100705 PG 24 WC Materials Science, Composites; Polymer Science SC Materials Science; Polymer Science GA JC378 UT WOS:A1992JC37800005 ER PT J AU UNDERWOOD, JH BURR, W KAPUSTA, AA RICKARD, CA AF UNDERWOOD, JH BURR, W KAPUSTA, AA RICKARD, CA TI CHARACTERIZATION OF EARLY AND MODERN WIRE FOR AN ITALIAN HARPSICHORD SO JOURNAL OF TESTING AND EVALUATION LA English DT Article DE BRASS WIRE; HARPSICHORD; MUSICAL INSTRUMENT; MICROHARDNESS; MICROSTRUCTURE AB The characterization of early and modern harpsichord wire is described, part of the musical restoration of a 1610 Italian harpsichord. Three sizes of brass wire believed to be original strings of the harpsichord and one type of steel wire also found with the instrument were characterized using a variety of metallographic tests. Three similar sizes of modern brass wire used in the restoration of the instrument were also characterized and compared with the early wire. Microhardness and microstructure were evaluated using optical microscopy, and the overall and surface appearances and chemical constituents of the wires were determined using scanning electron microscopy. Microhardness results were used to obtain estimates of tensile strength of the wires. Various aspects of the results were discussed in relation to three time periods of the instrument: the early 1600s when it was crafted, the late 1800s when it may have been fraudulently represented as a mid-1500s instrument, and its current use as a restored instrument. C1 USA,CTR ARMAMENT RES DEV & ENGN,WATERVLIET,NY. NR 5 TC 0 Z9 0 U1 1 U2 1 PU AMER SOC TESTING MATERIALS PI W CONSHOHOCKEN PA 100 BARR HARBOR DR, W CONSHOHOCKEN, PA 19428-2959 SN 0090-3973 J9 J TEST EVAL JI J. Test. Eval. PD JUL PY 1992 VL 20 IS 4 BP 312 EP 317 PG 6 WC Materials Science, Characterization & Testing SC Materials Science GA JY513 UT WOS:A1992JY51300009 ER PT J AU TISCHLER, MB CAUFFMAN, MG AF TISCHLER, MB CAUFFMAN, MG TI FREQUENCY-RESPONSE METHOD FOR ROTORCRAFT SYSTEM-IDENTIFICATION - FLIGHT APPLICATIONS TO BO-105 COUPLED ROTOR FUSELAGE DYNAMICS SO JOURNAL OF THE AMERICAN HELICOPTER SOCIETY LA English DT Article AB A comprehensive frequency-response method for rotorcraft system identification is presented. The overall concept is to 1) extract a complete set of non-parametric input-to-output frequency responses that fully characterizes the coupled helicopter dynamics, and 2) conduct a nonlinear search for a state-space model that matches the frequency-response data set. Each major element of the procedure is reviewed. A new method for combining the results of multi-input frequency-response analyses obtained from a range of spectral windows into a single optimized response is presented. This method eliminates the need for manual optimization of windows and significantly improves the dynamic range and accuracy of the identified frequency-responses relative to single window methods. An integrated user-oriented software package for the frequency-response method is described: Comprehensive Identification from FrEquency Responses (CIFER). CIFER is used to identify a 9-DOF hybrid model of the DLR BO 105 dynamics from flight test data at 80 knots. The identified model includes coupled body/rotor-flapping and lead-lag dynamics, and is accurate to 30 rad/sec. The 9-DOF results are compared with 6-DOF (quasi-steady) identification results. An application of the model to flight control design shows that the maximum roll rate gain is limited by the destabilization of the lead-lag dynamics. C1 STERLING SOFTWARE,PALO ALTO,CA. RP TISCHLER, MB (reprint author), USA,AVIAT RES & TECHNOL ACT,AMES RES CTR,AEROFLIGHTDYNAM DIRECTORATE,MOFFETT FIELD,CA 94035, USA. NR 27 TC 61 Z9 67 U1 0 U2 3 PU AMER HELICOPTER SOC INC PI ALEXANDRIA PA 217 N WASHINGTON ST, ALEXANDRIA, VA 22314 SN 0002-8711 J9 J AM HELICOPTER SOC JI J. Am. Helicopter Soc. PD JUL PY 1992 VL 37 IS 3 BP 3 EP 17 PG 15 WC Engineering, Aerospace SC Engineering GA JH133 UT WOS:A1992JH13300001 ER PT J AU SEN, JK BOLUKBASI, AO CHASE, NA AF SEN, JK BOLUKBASI, AO CHASE, NA TI TEST AND ANALYSIS OF AN ADVANCED TECHNOLOGY LANDING GEAR SO JOURNAL OF THE AMERICAN HELICOPTER SOCIETY LA English DT Article AB A retractable, crashworthy main landing gear for a utility helicopter was designed, fabricated and tested to the crashworthiness requirements of a vertical velocity of 42 fps, at +/-10-degrees roll and -5-degrees/+15-degrees pitch. The landing gear is very compact and highly maintainable, and automatically extends in less than two seconds in an emergency. Through energy absorbing trade-off studies and crashworthiness analyses, the gear was optimized to absorb 60 percent of the energy from a level impact at 42 fps; the remaining energy was absorbed by the fuselage and the stroking seat. The landing gear was evaluated through single-gear platform and iron-bird drop tests. Analytical models were also used to predict the performance of the landing gear design. The analysis results compared very well with the test results. The test and analysis results identified differences in the behavior of the gear in the two types of tests. C1 USA,AVIAT APPL TECHNOL DIRECTORATE,FT EUSTIS,VA. RP SEN, JK (reprint author), MCDONNELL DOUGLAS HELICOPTER CO,MESA,AZ 85205, USA. NR 5 TC 2 Z9 2 U1 2 U2 3 PU AMER HELICOPTER SOC INC PI ALEXANDRIA PA 217 N WASHINGTON ST, ALEXANDRIA, VA 22314 SN 0002-8711 J9 J AM HELICOPTER SOC JI J. Am. Helicopter Soc. PD JUL PY 1992 VL 37 IS 3 BP 42 EP 52 PG 11 WC Engineering, Aerospace SC Engineering GA JH133 UT WOS:A1992JH13300004 ER PT J AU ZEID, A CHUNG, CH AF ZEID, A CHUNG, CH TI BOND GRAPH MODELING OF MULTIBODY SYSTEMS - A LIBRARY OF 3-DIMENSIONAL JOINTS SO JOURNAL OF THE FRANKLIN INSTITUTE-ENGINEERING AND APPLIED MATHEMATICS LA English DT Article AB The Karnopp-Margolis method of modeling mechanisms is not only intuitively appealing, but it is also equivalent to the classical Lagrangian multiplier approach that produces the dynamic equations in state space form (Zeid, Trans. ASME J. Dyn. Syst. Meas. Control, Vol. 111, pp. 15-23, 1989). This paper details modeling space mechanisms and multibody systems using the Karnopp-Margolis method. A bond graph library is given for six types of joints that are common in building space mechanisms. These joints can be modeled using bond graph processors, or coded using any simulation language macro facility, and then stored in a library of joints. Using a suitable macro capability, bond graph processors, such as ENPORT or CAMP, can easily model multibody systems by using this library of joints. Moreover, bond graph models of joints may be used to investigate nonlinear properties of joints and to develop new types of joints. C1 WAYNE STATE UNIV,DEPT MECH ENGN,DETROIT,MI 48202. RP ZEID, A (reprint author), COMP SCI CORP,USA,HIGH PERFORMANCE COMP RES CTR,POB 5156,WARREN,MI 48090, USA. NR 6 TC 20 Z9 21 U1 0 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0016-0032 J9 J FRANKLIN I JI J. Frankl. Inst.-Eng. Appl. Math. PD JUL PY 1992 VL 329 IS 4 BP 605 EP 636 DI 10.1016/0016-0032(92)90076-S PG 32 WC Automation & Control Systems; Engineering, Multidisciplinary; Engineering, Electrical & Electronic; Mathematics, Interdisciplinary Applications SC Automation & Control Systems; Engineering; Mathematics GA JE859 UT WOS:A1992JE85900001 ER PT J AU LIPP, LJ AF LIPP, LJ TI METHODOLOGY OF DEVELOPING A COMBINED ENVIRONMENTAL-STRESS SCHEDULE FOR RELIABILITY GROWTH TESTING .2. THE TRACKED VEHICLE VIBRATION ENVIRONMENT SO JOURNAL OF THE IES LA English DT Article DE TEST TAILORING; RELIABILITY GROWTH; MISSION PROFILES; VIBRATION AB This three-part series describes how to develop an environmental test schedule for military ground-mobile equipment installed on a tracked vehicle based on the user's mission profile. The test schedules combine both operational and storage environmental stresses. Part I describes the equipment to be tested, provides a general overview of its mission profiles, and identifies appropriate climatic conditions. Part II discusses the complexities of the tracked-vehicle vibration environment, including research conducted in the Arizona desert and the Alaskan arctic. Part III compares test profiles based on excluding benign environmental phases with profiles that include benign stress conditions. RP LIPP, LJ (reprint author), USA,ARMAMENT MUNIT & CHEM COMMAND,ABERDEEN PROVING GROUND,MD 21010, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU INST ENVIRONMENTAL SCI PI MT PROSPECT PA 940 E NORTHWEST HIGHWAY, MT PROSPECT, IL 60056 SN 1052-2883 J9 J IES JI J. IES PD JUL-AUG PY 1992 VL 35 IS 4 BP 45 EP 54 PG 10 WC Engineering, Environmental; Environmental Sciences; Instruments & Instrumentation SC Engineering; Environmental Sciences & Ecology; Instruments & Instrumentation GA JK445 UT WOS:A1992JK44500007 ER PT J AU COLWELL, GT MODLIN, JM AF COLWELL, GT MODLIN, JM TI HEAT PIPE AND SURFACE MASS-TRANSFER COOLING OF HYPERSONIC VEHICLE STRUCTURES SO JOURNAL OF THERMOPHYSICS AND HEAT TRANSFER LA English DT Article AB This paper describes the results of an investigation conducted to study the feasibility of cooling hypersonic vehicle leading-edge structures exposed to severe aerodynamic surface heat fluxes using a combination of liquid metal heat pipe and surface mass transfer cooling techniques. A generalized, transient, finite difference-based hypersonic leading-edge cooling model was developed that incorporated these effects and was demonstrated on an assumed aerospace plane-type wing leading-edge section. An existing experimentally verified heat pipe model was modified by adding both transpiration and film cooling options as new surface boundary conditions. The models used to predict the leading-edge surface heat transfer reduction effects of transpiration and film cooling were modifications of more generalized, empirical-based models obtained from the literature. The leading-edge cooling model was demonstrated on an assumed aerospace plane-type wing leading-edge section exposed to a severe laminar, hypersonic aerodynamic surface heat flux. A 1-in.-nose diameter leading-edge structure was cooled using a lithium-filled heat pipe supplemented by either surface transpiration, surface film, or internal active heat exchanger cooling while executing a 2000 psf constant dynamic pressure hypersonic ascent flight trajectory. Results included transient structural temperature distributions, transient aerodynamic heat inputs, and transient surface coolant distributions. The study indicated that these cooling techniques limited the maximum leading-edge surface temperatures, moderated the structural temperature gradients, and led to the conclusion that cooling leading-edge structures exposed to severe hypersonic flight environments using a combination of liquid metal heat pipe, surface transpiration, and film cooling methods appeared feasible. C1 GEORGIA INST TECHNOL, ATLANTA, GA 30332 USA. USA, STRATEG DEF COMMAND, HUNTSVILLE, AL 35807 USA. NR 36 TC 7 Z9 9 U1 0 U2 2 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091-4344 USA SN 0887-8722 J9 J THERMOPHYS HEAT TR JI J. Thermophys. Heat Transf. PD JUL-SEP PY 1992 VL 6 IS 3 BP 492 EP 499 DI 10.2514/3.387 PG 8 WC Thermodynamics; Engineering, Mechanical SC Thermodynamics; Engineering GA JQ546 UT WOS:A1992JQ54600016 ER PT J AU MODLIN, JM COLWELL, GT AF MODLIN, JM COLWELL, GT TI SURFACE COOLING OF SCRAMJET ENGINE INLETS USING HEAT PIPE, TRANSPIRATION, AND FILM COOLING SO JOURNAL OF THERMOPHYSICS AND HEAT TRANSFER LA English DT Article AB This article reports the results of applying a finite-difference-based computational technique to the problem of predicting the transient thermal behavior of a scramjet engine inlet exposed to a typical hypersonic flight aerodynamic surface heating environment, including type IV shock interference heating. The leading-edge cooling model utilized incorporates liquid metal heat pipe cooling with surface transpiration and film cooling. Results include transient structural temperature distributions, aerodynamic heat inputs, and surface coolant distributions. It seems that these cooling techniques may be used to hold maximum skin temperatures to near acceptable values during the severe aerodynamic and type IV shock interference heating effects expected on the leading edge of a hypersonic aerospace vehicle scramjet engine. C1 USA, STRATEG DEF COMMAND, HUNTSVILLE, AL 35807 USA. GEORGIA INST TECHNOL, GW WOODRUFF SCH MECH ENGN, ATLANTA, GA 30332 USA. NR 15 TC 6 Z9 7 U1 0 U2 6 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091-4344 USA SN 0887-8722 J9 J THERMOPHYS HEAT TR JI J. Thermophys. Heat Transf. PD JUL-SEP PY 1992 VL 6 IS 3 BP 500 EP 504 DI 10.2514/3.388 PG 5 WC Thermodynamics; Engineering, Mechanical SC Thermodynamics; Engineering GA JQ546 UT WOS:A1992JQ54600017 ER PT J AU HELLMAN, OC HERBOTS, N VANCAUWENBERGHE, O CULBERTSON, RJ CROFT, WJ AF HELLMAN, OC HERBOTS, N VANCAUWENBERGHE, O CULBERTSON, RJ CROFT, WJ TI MICROSTRUCTURE AND STOICHIOMETRY DEPENDENCE OF ION-BEAM NITRIDES AS A FUNCTION OF ENERGY AND TEMPERATURE - A COMPARATIVE-STUDY BETWEEN SI AND SIGE SO JOURNAL OF VACUUM SCIENCE & TECHNOLOGY A LA English DT Article ID SILICON-NITRIDE; ASSISTED DEPOSITION; INDUCED EPITAXY; WET OXIDATION; GE FILMS; RECOMBINATION; DIFFUSION; NITROGEN; KINETICS; LAYERS AB The microstructure and stoichiometry of nitrides formed by direct low-energy ion beam nitridation has been investigated as a function of ion energy and substrate temperature for Si(100) and SiGe/Si(100) films. Cross-sectional transmission electron microscopy, Rutherford backscattering spectroscopy combined with ion channeling and in situ x-ray photoelectron spectroscopy were used. It was established that a substrate temperature of 700 K produces a homogeneous amorphous nitride layer, whereas lower substrate temperatures decrease the incorporation of nitrogen in the film, while causing the formation of a nitrogen-poor amorphous layer beneath the nitride film. The N-to-Si or N-to-(Si + Ge) atomic ratio is found be close to 1.33 at 1 keV and decreases with ion energy. Effects due to chemically enhanced physical sputtering of germanium are observed. C1 ARIZONA STATE UNIV, DEPT PHYS & ASTRON, TEMPE, AZ 85287 USA. MIT, DEPT MAT SCI & ENGN, CAMBRIDGE, MA 02139 USA. USA, MAT TECHNOL LAB, WATERTOWN, MA 02172 USA. RP HELLMAN, OC (reprint author), NIPPON TELEGRAPH & TEL PUBL CORP, MUSASHINO ELECT COMMUN LAB, BANC RES LABS, MUSASHINO, TOKYO 180, JAPAN. NR 46 TC 8 Z9 8 U1 0 U2 1 PU A V S AMER INST PHYSICS PI MELVILLE PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA SN 0734-2101 EI 1520-8559 J9 J VAC SCI TECHNOL A JI J. Vac. Sci. Technol. A PD JUL-AUG PY 1992 VL 10 IS 4 BP 1631 EP 1636 DI 10.1116/1.577761 PN 2 PG 6 WC Materials Science, Coatings & Films; Physics, Applied SC Materials Science; Physics GA JE682 UT WOS:A1992JE68200042 ER PT J AU HIROSE, Y HORNG, S KAHN, A WRENN, C PFEFFER, R AF HIROSE, Y HORNG, S KAHN, A WRENN, C PFEFFER, R TI ELECTRON-BEAM PATTERNING OF EPITAXIAL CAF2 AND CA0.5SR0.5F2/(100)GAAS SO JOURNAL OF VACUUM SCIENCE & TECHNOLOGY A-VACUUM SURFACES AND FILMS LA English DT Article; Proceedings Paper CT 38TH NATIONAL SYMP OF THE AMERICAN VACUUM SOC CY NOV 10-15, 1991 CL SEATTLE, WA SP AMER VACUUM SOC ID SURFACES; RESIST AB The electron beam patterning of crystalline CaF2 and Ca0.5Sr0.5F2 thin films grown by molecular-beam epitaxy is demonstrated. The mechanism leading to patterning is the removal of fluorine through high energy electron beam exposure and dissolution of the resulting metal oxide in a water-based solution. A scanning Auger microprobe and a scanning electron microscope are used as exposing tools. The development of the films is performed either in deionized water or in a weak HCl solution. The chemical analysis of the patterned features confirms the development of small windows. The feasibility of the fabrication of micrometers features is verified. C1 USA,ELECTR TECHNOL & DEVICES LAB,FT MONMOUTH,NJ 07703. RP HIROSE, Y (reprint author), PRINCETON UNIV,DEPT ELECT ENGN,PRINCETON,NJ 08544, USA. NR 10 TC 11 Z9 11 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0734-2101 J9 J VAC SCI TECHNOL A JI J. Vac. Sci. Technol. A-Vac. Surf. Films PD JUL-AUG PY 1992 VL 10 IS 4 BP 960 EP 964 DI 10.1116/1.577886 PN 1 PG 5 WC Materials Science, Coatings & Films; Physics, Applied SC Materials Science; Physics GA JE681 UT WOS:A1992JE68100072 ER PT J AU MEYYAPPAN, M MCLANE, GF COLE, MW LARAEU, R NAMAROFF, M SASSERATH, J AF MEYYAPPAN, M MCLANE, GF COLE, MW LARAEU, R NAMAROFF, M SASSERATH, J TI MAGNETRON ETCHING OF GAAS - ETCH CHARACTERISTICS AND SURFACE CHARACTERIZATION SO JOURNAL OF VACUUM SCIENCE & TECHNOLOGY A-VACUUM SURFACES AND FILMS LA English DT Article; Proceedings Paper CT 38TH NATIONAL SYMP OF THE AMERICAN VACUUM SOC CY NOV 10-15, 1991 CL SEATTLE, WA SP AMER VACUUM SOC ID ION; CHEMISTRY; ALGAAS; PLASMA; RATES AB Etching of GaAs in a magnetron reactor was investigated using two different etch gases, namely SiCl4 and freon-12 (CF2Cl2). SiCl4 etching yielded vertical sidewalls, whereas the etched profiles in the case of freon exhibited a negative undercut. Surface characterization was undertaken using Auger electron spectroscopy, x-ray photoelectron spectroscopy, and secondary ion mass spectroscopy to determine the composition and chemical bonding in the near-surface region of the etched samples. The etched surface in the case of SiCl4 was found to be free of any chlorine residue and predominantly GaAs. However, there were residues of Si on the sidewalls. GaF3 formation was observed in GaAs samples etched in freon-12; in addition a C(x)F(y) fluorocarbon layer was present at high pressures which may not have been effectively removed due to reduced ion bombardment. C1 USA,ELECTR TECHNOL & DEVICES LAB,FT MONMOUTH,NJ 07703. MAT RES CORP,ORANGEBURG,NY 10962. ECOLE POLYTECH,MONTREAL H3C 3A7,QUEBEC,CANADA. RP MEYYAPPAN, M (reprint author), SCI RES ASSOCIATES INC,POB 1058,GLASTONBURY,CT 06033, USA. NR 10 TC 9 Z9 9 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0734-2101 J9 J VAC SCI TECHNOL A JI J. Vac. Sci. Technol. A-Vac. Surf. Films PD JUL-AUG PY 1992 VL 10 IS 4 BP 1147 EP 1151 DI 10.1116/1.578217 PN 1 PG 5 WC Materials Science, Coatings & Films; Physics, Applied SC Materials Science; Physics GA JE681 UT WOS:A1992JE68100104 ER PT J AU RAJAVEL, D WAGNER, BK BENZ, RG CONTE, A MARUYAMA, K SUMMERS, CJ BENSON, JD AF RAJAVEL, D WAGNER, BK BENZ, RG CONTE, A MARUYAMA, K SUMMERS, CJ BENSON, JD TI GAS SOURCE IODINE DOPING AND CHARACTERIZATION OF MOLECULAR-BEAM EPITAXIALLY GROWN CDTE SO JOURNAL OF VACUUM SCIENCE & TECHNOLOGY B LA English DT Article AB Investigations are reported on the gas source iodine doping of CdTe grown by molecular-beam epitaxy, utilizing ethyliodide as the dopant precursor. Structural and electrical characterizations of these layers showed them to have favorable crystalline properties and indicated that the electrical activity of iodine in CdTe was between 50% and 100%. Electron concentrations between 6 X 10(16) and 3 X 10(18) cm-3 were obtained and showed the highest mobilities measured in epitaxial n-type CdTe. These studies also showed that the incorporation of iodine was independent of the II/VI flux ratio and that its electrical activity was independent of both dopant concentration and II/VI flux ratio. The photoluminescence spectrum at 10 K was dominated by strong excitonic recombination bound to ionized and neutral iodine donors. These results demonstrate that iodine is a highly effective donor in CdTe. C1 USA,COMMUN ELECTR COMMAND,CTR NIGHT VIS & ELECTROOPT,FT BELVOIR,VA 22060. RP RAJAVEL, D (reprint author), GEORGIA TECH RES INST,PHYS SCI LAB,ATLANTA,GA 30332, USA. NR 20 TC 19 Z9 19 U1 1 U2 1 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 1071-1023 J9 J VAC SCI TECHNOL B JI J. Vac. Sci. Technol. B PD JUL-AUG PY 1992 VL 10 IS 4 BP 1432 EP 1437 DI 10.1116/1.586267 PG 6 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Physics, Applied SC Engineering; Science & Technology - Other Topics; Physics GA JJ600 UT WOS:A1992JJ60000031 ER PT J AU VYDYANATH, HR ELLSWORTH, J KENNEDY, JJ DEAN, B JOHNSON, CJ NEUGEBAUER, GT SEPICH, J LIAO, PK AF VYDYANATH, HR ELLSWORTH, J KENNEDY, JJ DEAN, B JOHNSON, CJ NEUGEBAUER, GT SEPICH, J LIAO, PK TI RECIPE TO MINIMIZE TE PRECIPITATION IN CDTE AND (CD,ZN)TE CRYSTALS SO JOURNAL OF VACUUM SCIENCE & TECHNOLOGY B LA English DT Article ID GROWTH AB Using a quasichemical approach, the total native defect concentration and the minimum deviation in stoichiometry have been calculated in CdTe crystals as a function of the Cd pressure at various temperatures. With this knowledge, CdTe and (Cd,Zn)Te wafers have been subjected to postgrowth step annealing treatment under conditions such that the crystals are in equilibrium with a Cd or (Cd,Zn) vapor corresponding to the minimum in deviation from stoichiometry at each annealing temperature. The step annealed CdTe and (Cd,Zn)Te wafers have been examined under infrared microscopy and have shown significant reduction in the concentration of Te precipitates, whereas the unannealed wafers have had numerous Te precipitates distributed throughout the bulk. HgCdTe epitaxial films have been grown on the step annealed CdTe and (Cd,Zn)Te wafers as well as on unannealed wafers from the same boule. Examination of the cross sections of the epitaxial films indicates appearance of Te precipitates in films grown on unannealed substrates, whereas no Te precipitation was evident in films grown on the annealed substrates leading to the inference that the occurrence of Te precipitates in the (Hg,Cd)Te films is possibly related to the presence of Te precipitates in the substrates. Thermal migration of Te under a temperature gradient during step annealing is suggested as a possible mechanism in the elimination of larger size Te precipitates whereas the extremely fine precipitates (< 1-mu-m) appear to need in-diffusion of metal vapor for their elimination. C1 USA,CTR NIGHT VIS & ELECTROOPT,FT BELVOIR,VA 22060. II-VI INC,SAXONBURG,PA 16056. TEXAS INSTRUMENTS INC,DALLAS,TX 75265. RP VYDYANATH, HR (reprint author), AEROJET ELECTR SYST DIV,AZUSA,CA 91702, USA. RI Chang, Yong/B-3541-2009 NR 12 TC 70 Z9 73 U1 2 U2 6 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 1071-1023 J9 J VAC SCI TECHNOL B JI J. Vac. Sci. Technol. B PD JUL-AUG PY 1992 VL 10 IS 4 BP 1476 EP 1484 DI 10.1116/1.586275 PG 9 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Physics, Applied SC Engineering; Science & Technology - Other Topics; Physics GA JJ600 UT WOS:A1992JJ60000039 ER PT J AU KOPANSKI, JJ LOWNEY, JR NOVOTNY, DB SEILER, DG SIMMONS, A RAMSEY, J AF KOPANSKI, JJ LOWNEY, JR NOVOTNY, DB SEILER, DG SIMMONS, A RAMSEY, J TI HIGH-SPATIAL-RESOLUTION RESISTIVITY MAPPING APPLIED TO MERCURY CADMIUM TELLURIDE SO JOURNAL OF VACUUM SCIENCE & TECHNOLOGY B LA English DT Article ID HG1-XCDXTE AB The fine-scale resistivity variations of slices of bulk, n-type Hg1-xCdxTe (HgCdTe) grown by the solid-state recrystallization (SSR) process and thin-film epitaxial layers of HgCdTe grown by liquid phase epitaxy (LPE) on SSR substrates were mapped at room temperature (297 K). An automatic probe station was used to make four-probe resistance measurements, spaced 80-mu-m apart, on lithographically defined metal-to-HgCdTe contacts. Most slices of SSR HgCdTe were found to have resistivities that increased from the center to the outside edge, and some SSR material also showed small inclusions with resistivity either higher or lower than the surrounding material. LPE material was found to have a more random variation in resistivity than SSR HgCdTe material. Also, the metal-semiconductor contact resistivity of In/Pb/In/Ni contacts to n-type HgCdTe was measured to be in the range of 0.3 to 20 X 10(-5) OMEGA-cm2 for HgCdTe resistivities varying from 0.01 to 0.1-OMEGA-cm. C1 TEXAS INSTRUMENTS INC,DALLAS,TX 75265. USA,CECOM,CTR NIGHT VIS & ELECTROOPT,FT BELVOIR,VA 22060. RP KOPANSKI, JJ (reprint author), NATL INST STAND & TECHNOL,GAITHERSBURG,MD 20899, USA. NR 11 TC 3 Z9 3 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 1071-1023 J9 J VAC SCI TECHNOL B JI J. Vac. Sci. Technol. B PD JUL-AUG PY 1992 VL 10 IS 4 BP 1553 EP 1559 DI 10.1116/1.586248 PG 7 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Physics, Applied SC Engineering; Science & Technology - Other Topics; Physics GA JJ600 UT WOS:A1992JJ60000051 ER PT J AU SCHEFFNER, NW BORGMAN, LE AF SCHEFFNER, NW BORGMAN, LE TI STOCHASTIC TIME-SERIES REPRESENTATION OF WAVE DATA SO JOURNAL OF WATERWAY PORT COASTAL AND OCEAN ENGINEERING-ASCE LA English DT Article AB This paper describes a procedure for generating-simulated time sequences of wave height, period, and direction data at specific locations. The technique uses a finite length wave record to compute a matrix of coefficient multipliers, which are used to generate arbitrarily long time sequences of simulated wave data, preserving the primary statistical properties of the finite data set. The procedure was developed for simulating time series from the Wave information Study (WIS) data base, a 20-year hindcast of wave height, period, and direction provided at three-hour intervals for locations along United States coasts and the Great Lakes. Application of the methodology is demonstrated in this paper through comparisons of simulated data with hindcast data corresponding to a Gulf of Mexico WIS station near the entrance to Mobile Bay, Alabama. Analysis of the results indicate that the simulated time series does exhibit the primary statistical properties of the WIS data, including winter and summer seasonal patterns and wave sequencing. C1 UNIV WYOMING,LARAMIE,WY 82070. RP SCHEFFNER, NW (reprint author), USA,COASTAL ENGN RES CTR,ENGN WATERWAYS EXPT STN,VICKSBURG,MS 39180, USA. NR 7 TC 17 Z9 17 U1 0 U2 2 PU ASCE-AMER SOC CIVIL ENGINEERS PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-950X J9 J WATERW PORT C-ASCE JI J. Waterw. Port Coast. Ocean Eng.-ASCE PD JUL-AUG PY 1992 VL 118 IS 4 BP 337 EP 351 DI 10.1061/(ASCE)0733-950X(1992)118:4(337) PG 15 WC Engineering, Civil; Engineering, Ocean; Water Resources SC Engineering; Water Resources GA JA336 UT WOS:A1992JA33600001 ER PT J AU BURTON, DM HEFFNER, DK PATOW, CA AF BURTON, DM HEFFNER, DK PATOW, CA TI GRANULAR-CELL TUMORS OF THE TRACHEA SO LARYNGOSCOPE LA English DT Article ID MYOBLASTOMA; HEAD; NECK AB In contrast to the relative frequency of granular cell tumors (GCT) in the larynx and bronchi, the occurrence of these tumors in the trachea is rare. A 50-year review of the English-language literature disclosed only 24 described cases of tracheal GCT. This report reviews the clinicopathologic data from those 24 cases, along with the data from 2 cases obtained via a personal communication and the data from 4 previously unpublished cases obtained from a 30-year review of the Armed Forces Institute of Pathology archives. Tracheal resection was the predominant mode of therapy and often was performed as a salvage procedure for failed endoscopic excisions. Recommendations for a more uniform approach to surgical management are provided. C1 UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. ARMED FORCES INST PATHOL,DEPT OTOLARYNG PATHOL,WASHINGTON,DC 20306. RP BURTON, DM (reprint author), BROOKE ARMY MED CTR,OTOLARYNGOL HEAD & NECK SURG,SAN ANTONIO,TX 78235, USA. NR 27 TC 22 Z9 22 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0023-852X J9 LARYNGOSCOPE JI Laryngoscope PD JUL PY 1992 VL 102 IS 7 BP 807 EP 813 DI 10.1288/00005537-199207000-00010 PG 7 WC Medicine, Research & Experimental; Otorhinolaryngology SC Research & Experimental Medicine; Otorhinolaryngology GA JK415 UT WOS:A1992JK41500010 PM 1614251 ER PT J AU MAURETTE, M CRAGIN, J TAYLOR, S AF MAURETTE, M CRAGIN, J TAYLOR, S TI COSMIC DUST IN APPROXIMATE-TO 50 KG BLOCKS OF BLUE ICE FROM CAP-PRUDHOMME AND RANGE,ALEXANDRA, ANTARCTICA SO METEORITICS LA English DT Meeting Abstract C1 CTR SPECTROMETRIE NUCL & SPECTROMETRIE MASSE, F-91405 ORSAY, FRANCE. COLD REG RES & ENGN LAB, HANOVER, NH 03755 USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU METEORITICAL SOC PI FAYETTEVILLE PA DEPT CHEMISTRY/BIOCHEMISTRY, UNIV ARKANSAS, FAYETTEVILLE, AR 72701 USA SN 0026-1114 J9 METEORITICS JI Meteoritics PD JUL PY 1992 VL 27 IS 3 BP 257 EP 257 PG 1 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA JE029 UT WOS:A1992JE02900129 ER PT J AU COLEF, G AF COLEF, G TI BANDWIDTH EXTENSION FOR 6-PORT REFLECTOMETERS VIA A SIMPLE NUMERICAL-METHOD SO MICROWAVE AND OPTICAL TECHNOLOGY LETTERS LA English DT Article DE 6-PORT REFLECTOMETER; BANDWIDTH EXTENSION; CIRCLES INTERSECTIONS; REFERENCE VALUE AB A simple numerical method for extension of the bandwidth of six-port reflectometers is proposed. The bandwidth extension is accomplished through calculations and not by six-port design improvements. The method is tested on a microstrip integrated six-port reflectometer and results for different loads are presented. RP COLEF, G (reprint author), USA,MERCHANT MARINE ACAD,DEPT ENGN,KINGS POINT,NY 11024, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU JOHN WILEY & SONS INC PI NEW YORK PA 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0895-2477 J9 MICROW OPT TECHN LET JI Microw. Opt. Technol. Lett. PD JUL PY 1992 VL 5 IS 8 BP 374 EP 376 DI 10.1002/mop.4650050810 PG 3 WC Engineering, Electrical & Electronic; Optics SC Engineering; Optics GA HU352 UT WOS:A1992HU35200009 ER PT J AU ASCHER, DP LAMPE, RM CIESLAK, TJ AF ASCHER, DP LAMPE, RM CIESLAK, TJ TI INTERCOUNTRY ADOPTION BY MILITARY FAMILY MEMBERS SO MILITARY MEDICINE LA English DT Article RP ASCHER, DP (reprint author), WALTER REED ARMY MED CTR,DEPT PEDIAT,WASHINGTON,DC 20307, USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUL PY 1992 VL 157 IS 7 BP 331 EP 334 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA JD344 UT WOS:A1992JD34400005 PM 1528464 ER PT J AU FRIEDL, KE PATIENCE, TH NUOVO, JA DETTORI, JR AF FRIEDL, KE PATIENCE, TH NUOVO, JA DETTORI, JR TI FACTORS ASSOCIATED WITH STRESS-FRACTURE IN YOUNG ARMY WOMEN - INDICATIONS FOR FURTHER RESEARCH SO MILITARY MEDICINE LA English DT Article AB Several factors which affect bone density and predict risk of osteoporosis (e.g., ethnic origin, amenorrhea) are reportedly associated with a higher incidence of stress fracture in active premenopausal women. The authors surveyed 2,312 active duty Army women for the prevalence of ever having been diagnosed ("told by a doctor") with a stress fracture (16.1% of respondents) and examined the relationship between surveyable risk factors for low bone density and this self-reported stress fracture history (self-reported SF). Current smoking, previous history of amenorrhea (menses absent > 6 months), and known family history of osteoporosis were significantly associated with self-reported SF, while black ethnic origin was a protective factor. These data suggest hypotheses of stress fracture pathogenesis in Army women which bear further testing. RP FRIEDL, KE (reprint author), USA,ENVIRONM MED RES INST,DIV OCCUPAT PHYSIOL,NATICK,MA 01760, USA. OI Friedl, Karl/0000-0002-3134-8427 NR 0 TC 75 Z9 75 U1 1 U2 3 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUL PY 1992 VL 157 IS 7 BP 334 EP 338 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA JD344 UT WOS:A1992JD34400006 PM 1528465 ER PT J AU RITCHIE, EC ROSS, B RADKE, AQ AF RITCHIE, EC ROSS, B RADKE, AQ TI DEPRESSION AND SUPPORT SYSTEMS IN MALE ARMY HIV POSITIVE PATIENTS SO MILITARY MEDICINE LA English DT Article AB Psychiatric interviews were conducted with 55 male Army HIV+ patients. These soldiers were diagnosed in an early stage of HIV, and were not clinically demented. Sixty-four percent were given diagnoses of a depressive disorder by a psychiatrist, while 42% self-reported depression. Fifty-five percent had a history of suicidal thoughts since their diagnosis of HIV, but only one soldier was actively suicidal. Half said that they followed a more healthy lifestyle since their diagnoses. Factors associated with a high rate of depression included being divorced, of Hispanic origin, having other medical problems, or a history of mental illness. Not telling friends and family, or feeling a lack of support from them or the military, was also significantly correlated with depression. RP RITCHIE, EC (reprint author), WALTER REED ARMY MED CTR,DEPT PSYCHIAT,WASHINGTON,DC 20307, USA. NR 0 TC 12 Z9 12 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUL PY 1992 VL 157 IS 7 BP 345 EP 349 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA JD344 UT WOS:A1992JD34400009 PM 1528468 ER PT J AU KOSHES, RJ ROTHBERG, JM AF KOSHES, RJ ROTHBERG, JM TI PARASUICIDAL BEHAVIOR ON AN ACTIVE DUTY ARMY TRAINING POST SO MILITARY MEDICINE LA English DT Article AB The incidence of suicidal behavior among active duty Army personnel at a training post has not been the subject of analysis since the advent of the all-volunteer military. A review of admissions over 16 consecutive months showed most of the behaviors to be parasuicidal, with low levels of lethality and high rescuability. Compared to previously published studies, the characteristics of these soldiers are little changed over the past 25 years. This report suggests a standard method for handling suicidal behavior which includes an active role for psychiatric consultation to units and commanders. RP KOSHES, RJ (reprint author), KENNER ARMY COMMUNITY HOSP,DEPT PSYCHIAT,FT LEE,VA 23801, USA. NR 0 TC 11 Z9 11 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUL PY 1992 VL 157 IS 7 BP 350 EP 353 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA JD344 UT WOS:A1992JD34400010 PM 1528469 ER PT J AU CHISICK, MC RAKER, T LEE, S WILLIAMS, TR AF CHISICK, MC RAKER, T LEE, S WILLIAMS, TR TI A PROFILE OF TOBACCO USE AMONG TEENAGE DEPENDENTS SO MILITARY MEDICINE LA English DT Article AB This study profiles tobacco use by 2,241 dependent teenager in grades 6-12 at two Army posts. Data were collected in February 1989 by self-administered questionnaires. Results show 40.9% of dependent teenagers have tried smoking and 16.4% have tried smokeless tobacco. Most youths who tried tobacco did so experimentally. Current use is 10.4 % smoking and 2.8 % smokeless tobacco. While there is little difference in the proportion of boys and girls who have tried or currently smoke, trial and current use of smokeless tobacco is almost exclusively by males. Whites are more likely to ever use tobacco than other ethnic groups. RP CHISICK, MC (reprint author), USA,HLTH CARE STUDIES & CLIN INVEST ACTIV,DIV DENT STUDIES,FT SAM HOUSTON,TX 78234, USA. NR 0 TC 4 Z9 4 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUL PY 1992 VL 157 IS 7 BP 354 EP 357 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA JD344 UT WOS:A1992JD34400011 PM 1528470 ER PT J AU CALTON, WC GOODEN, SM MARTINDALE, RG AF CALTON, WC GOODEN, SM MARTINDALE, RG TI COMPLICATIONS OF PERCUTANEOUS ENDOSCOPIC GASTROSTOMY SO MILITARY MEDICINE LA English DT Article AB Percutaneous endoscopic gastrostomy (PEG) has become a commonly performed procedure to provide nutritional support to chronically ill patients. Following a PEG-related death, we retrospectively reviewed our complication rate with that of the published values. In the past 48 months at Madigan Army Medical Center and Eisenhower Army Medical Center, 147 PEGs have been performed. We have had 20 minor complications and 5 major complications, with 2 reported deaths directly related to the procedure. Minor complications included 14 cases of localized cellulitis and 5 cases of prolonged ileus. The major complications included two cases of necrotizing fasciitis (both fatal), two cases of tube extubation within 24 hours, both resulting in surgical gastrostomy, and one bowel obstruction requiring laparotomy. Both patients who developed necrotizing fasciitis had several predisposing factors including diabetes, malnutrition, obesity, and long-term hospitalization. In conclusion, we believe PEG is an extremely valuable procedure which should be utilized with caution in the immunocompromised or morbidly obese patient. RP CALTON, WC (reprint author), EISENHOWER ARMY MED CTR,DEPT SURG,FT GORDON,GA, USA. NR 0 TC 25 Z9 25 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUL PY 1992 VL 157 IS 7 BP 358 EP 360 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA JD344 UT WOS:A1992JD34400012 PM 1528471 ER PT J AU ROSENBERG, R RUNGSIWONGSE, J KANGSADALAMPAI, S SATTABONGKOT, J SUWANABUN, N CHAIYAROJ, SC MONGKOLSUK, S AF ROSENBERG, R RUNGSIWONGSE, J KANGSADALAMPAI, S SATTABONGKOT, J SUWANABUN, N CHAIYAROJ, SC MONGKOLSUK, S TI RANDOM MATING OF NATURAL PLASMODIUM POPULATIONS DEMONSTRATED FROM INDIVIDUAL OOCYSTS SO MOLECULAR AND BIOCHEMICAL PARASITOLOGY LA English DT Article DE MALARIA; OOCYST; POLYMERASE CHAIN REACTION; GENETICS; CIRCUMSPOROZOITE; PLASMODIUM-VIVAX ID VIVAX AB DNA amplified from individual Plasmodium vivax oocysts, produced by feeding mosquitoes directly on naturally infected humans in Thailand, was used to study cross-mating of 2 polymorphs of the circumsporozoite (CS) gene, VK 210 and VK 247. Alleles were detected in matched blood parasites, sporozoites, and individual oocysts with oligoprobes specific to characteristic repeat units. Oocysts developing from 3 cases in which mixed alleles were present in the blood parasites had genotype frequencies, including hybrids, consistent with the Hardy-Weinberg equilibrium. There was apparently no barrier to hybridization of the 2 alleles nor a bias, as has been found in some laboratory experiments, favoring hybrid formation. These are the first measurements of cross-mating frequencies directly from natural Plasmodium infections and the first observations of genetic hybridization in P. vivax. C1 MAHIDOL UNIV,FAC SCI,DEPT MICROBIOL,BANGKOK 10700,THAILAND. MAHIDOL UNIV,FAC SCI,DEPT BIOTECHNOL,BANGKOK 10700,THAILAND. RP ROSENBERG, R (reprint author), ARMED FORCES RES INST MED SCI,DEPT ENTOMOL,315-6 RAJVITHI RD,BANGKOK 10400,THAILAND. NR 10 TC 14 Z9 14 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-6851 J9 MOL BIOCHEM PARASIT JI Mol. Biochem. Parasitol. PD JUL PY 1992 VL 53 IS 1-2 BP 129 EP 133 DI 10.1016/0166-6851(92)90015-C PG 5 WC Biochemistry & Molecular Biology; Parasitology SC Biochemistry & Molecular Biology; Parasitology GA JB499 UT WOS:A1992JB49900014 PM 1501632 ER PT J AU SCHULTZ, JF LAVAN, MJ POGUE, EW MEYER, TW AF SCHULTZ, JF LAVAN, MJ POGUE, EW MEYER, TW TI THE HIGH AVERAGE POWER FREE-ELECTRON LASER PROGRAM SO NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT LA English DT Article; Proceedings Paper CT 13TH INTERNATIONAL CONF ON FREE ELECTRON LASER CY AUG 25-30, 1991 CL SANTA FE, NM SP USAF, OFF SCI RES, USA, STRATEG DEF COMMAND, US DOE, USN, OFF NAVAL RES, US STRATEG DEF INITIAT OFF, US NAVAL RES LAB ID 1ST OPERATION; EFFICIENCY AB The potential advantages of the FEL for military applications (tunability, short-wavelength operation, efficiency, and high power) have been the goals of the Joint U.S. Army/SDIO, and Defense Research Project Agency (DARPA) programs since 1976. From the outset of the program, it was clear that funding constraints would mandate the development and demonstration of these attributes in separate but closely coupled subscale technology efforts prior to integration in a full scale weapons prototype. These efforts have so far successfully demonstrated the tunability, short wavelength generation, and high extraction efficiency of FELs. Among the most important attributes and technologies that have been developed to date are validated design codes, high quality electron beams for short wavelength operation, ring resonators, tapered wigglers, optical gain guiding, cryogenic accelerator components, energy recovery, and critical high average power components such as CW433 MHz klystrons, photoinjectors, and accelerating cavities. These technologies will be integrated into the 10-mu-m, 100 kW average power laser experiment (APLE), which will be built at the Boeing facility in Seattle, and which can be upgraded to operate at higher powers and shorter wavelengths. The accomplishments of the program will be described, and the paths to a high power, cryogenic FEL wilt be outlined. C1 STRATEG DEF INITIAT ORG,TND,WASHINGTON,DC 20301. RP SCHULTZ, JF (reprint author), USA,STRATEG DEF COMMAND,CSSD,DE,POB 1500,HUNTSVILLE,AL 35807, USA. NR 22 TC 5 Z9 5 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0168-9002 J9 NUCL INSTRUM METH A JI Nucl. Instrum. Methods Phys. Res. Sect. A-Accel. Spectrom. Dect. Assoc. Equip. PD JUL 1 PY 1992 VL 318 IS 1-3 BP 9 EP 15 DI 10.1016/0168-9002(92)91014-Z PG 7 WC Instruments & Instrumentation; Nuclear Science & Technology; Physics, Nuclear; Physics, Particles & Fields SC Instruments & Instrumentation; Nuclear Science & Technology; Physics GA JD767 UT WOS:A1992JD76700003 ER PT J AU ARMSTRONG, RL XIE, JG RUEKGAUER, TE PINNICK, RG AF ARMSTRONG, RL XIE, JG RUEKGAUER, TE PINNICK, RG TI ENERGY-TRANSFER-ASSISTED LASING FROM MICRODROPLETS SEEDED WITH FLUORESCENT SOL SO OPTICS LETTERS LA English DT Article ID STIMULATED RAMAN-SCATTERING; MICROMETER-SIZED DROPLETS; MORPHOLOGY-DEPENDENT RESONANCES; AEROSOL-PARTICLE; LASER-EMISSION AB We report observations of lasing emission from liquid microdroplets of Fluorescein 548 dye in ethanol, seeded with submicrometer-sized fluorescent sol. An incident pump laser excites fluorescein dye molecules, which in tum couple energy to sol-dye molecules, generating lasing in the sol. The pump laser can also generate fluorescein lasing in the droplets, which may excite lasing in the sol. Other noteworthy findings include the absence of sol emission for larger sol and the presence of sol emission, even without any observable fluorescein emission, for smaller sol. All emissions are at wavelengths corresponding to morphology-dependent resonances of the droplet. Studies of the dependence of these emissions on pump laser intensity and sol concentration suggest that they are driven either by Forster energy transfer between fluorescein dye molecules and dye within the sol or by enhanced radiative transfer that occurs when fluorescein emission couples to morphology-dependent resonances of the droplet microcavity. C1 ATMOSPHER SCI LAB,WHITE SANDS MISSILE RANGE,NM 88002. RP ARMSTRONG, RL (reprint author), NEW MEXICO STATE UNIV,DEPT PHYS,LAS CRUCES,NM 88003, USA. NR 16 TC 36 Z9 36 U1 0 U2 1 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0146-9592 J9 OPT LETT JI Opt. Lett. PD JUL 1 PY 1992 VL 17 IS 13 BP 943 EP 945 DI 10.1364/OL.17.000943 PG 3 WC Optics SC Optics GA JA322 UT WOS:A1992JA32200014 PM 19794681 ER PT J AU RABIN, J ADAMS, AJ AF RABIN, J ADAMS, AJ TI CORTICAL POTENTIALS-EVOKED BY SHORT WAVELENGTH PATTERNED LIGHT SO OPTOMETRY AND VISION SCIENCE LA English DT Article DE S-CONES; BLUE CONES; VISUAL EVOKED RESPONSE; SPATIOCHROMATIC PROCESSING AB Pattern-evoked cortical potentials (PECPs) were recorded in response to the onset of blue and black, square wave gratings superimposed on a bright orange background. Several lines of evidence, including spectral sensitivity and the absence of response in a tritanopic subject, indicate that the measured cortical potentials reflect input from S cones. Spatial and temporal tuning of this response are comparable to psychophysical measures of the S-pathway. In agreement with previous studies of achromatic and chromatic spatial processing, a comparison of the response to patterns of different complexity indicates that spatial processing in the S-pathway can be described by linear systems analysis. An oblique effect for the S-pathway is demonstrated. Additional findings which bear on the nature of postreceptoral processing in the S-pathway are considered. Included are measurements from a patient with diabetic retinopathy. This study underscores the potential importance of the S-pathway for spatial information processing. RP RABIN, J (reprint author), USA,AEROMED RES LAB,DIV SENSORY RES,FT RUCKER,AL 36362, USA. FU NEI NIH HHS [EY 02271] NR 0 TC 6 Z9 7 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 1040-5488 J9 OPTOMETRY VISION SCI JI Optom. Vis. Sci. PD JUL PY 1992 VL 69 IS 7 BP 522 EP 531 DI 10.1097/00006324-199207000-00003 PG 10 WC Ophthalmology SC Ophthalmology GA JC961 UT WOS:A1992JC96100003 PM 1635755 ER PT J AU ROTHMAN, RB BYKOV, V JACOBSON, AE RICE, KC LONG, JE BOWEN, WD AF ROTHMAN, RB BYKOV, V JACOBSON, AE RICE, KC LONG, JE BOWEN, WD TI A STUDY OF THE EFFECT OF THE IRREVERSIBLE DELTA-RECEPTOR ANTAGONIST [D-ALA(2),LEU(5),CYS(6)]-ENKEPHALIN ON DELTA(CX) AND DELTA(NCX) OPIOID BINDING-SITES INVITRO AND INVIVO SO PEPTIDES LA English DT Article DE [D-ALA(2),LEU(5),CYS(6)]ENKEPHALIN; DALCE; OPIOID RECEPTORS; ANTINOCICEPTION ID NALTRINDOLE 5'-ISOTHIOCYANATE; OPIATE RECEPTORS; ENKEPHALIN; MORPHINE; NALTREXONE; TOLERANCE; SUBTYPES; COMPLEX; LIGAND AB Several lines of data support the existence of two classes of delta receptors: the delta(cx)-binding site, which is the delta-binding site of the mu-delta opioid receptor complex, and the delta(ncx), which is the noncomplexed delta-receptor. [D-Ala2,Leu5,Cys6]Enkephalin (DALCE) is an extended analog of [Leu5]enkephalin, which has been shown to bind irreversibly to delta-receptors via the terminal cysteine by formation of a disulfide bond with the receptor. In vivo studies have shown that DALCE produces short-lived antinociceptive actions, followed by long-term antagonism of delta-receptor-mediated antinociception. The major goal of the present study was to examine the effect of DALCE on the delta(cx) and delta(ncx)-binding sites in vitro and in vivo. Intracerebroventricular administration of 40-mu-g DALCE failed to decrease [H-3][D-Ala2,D-Leu5]enkephalin binding to the delta(cx) and delta(ncx)-binding sites. Pretreatment of membranes with DALCE in vitro greatly reduced the B(max) of the delta(ncx)-binding site, without significantly altering the B(max) of the delta(cx)-binding site. These findings suggest that when administered in vivo, DALCE fails to distribute uniformly throughout the brain, and that it therefore binds covalently to opioid receptors mostly in the periventricular regions. Viewed collectively, these data support the hypothesis that DALCE acts as a selective delta(ncx)-antagonist, and that the delta(ncx) binding site, which is sensitive to DALCE, is most likely synonymous with the recently described delta-1 receptor. C1 NIDDK,MED CHEM,BETHESDA,MD 20892. WALTER REED ARMY MED CTR,DEPT MED NEUROSCI,WASHINGTON,DC 20307. RP ROTHMAN, RB (reprint author), NIDA,ADDICT RES CTR,CLIN PSYCHOPHARMACOL SECT,POB 5180,BALTIMORE,MD 21224, USA. NR 18 TC 14 Z9 14 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0196-9781 J9 PEPTIDES JI Peptides PD JUL-AUG PY 1992 VL 13 IS 4 BP 691 EP 694 DI 10.1016/0196-9781(92)90174-2 PG 4 WC Biochemistry & Molecular Biology; Endocrinology & Metabolism; Pharmacology & Pharmacy SC Biochemistry & Molecular Biology; Endocrinology & Metabolism; Pharmacology & Pharmacy GA JL834 UT WOS:A1992JL83400010 PM 1331996 ER PT J AU LYON, JG LUNETTA, RS WILLIAMS, DC AF LYON, JG LUNETTA, RS WILLIAMS, DC TI AIRBORNE MULTISPECTRAL SCANNER DATA FOR EVALUATING BOTTOM SEDIMENT TYPES AND WATER DEPTHS OF THE ST MARYS RIVER, MICHIGAN SO PHOTOGRAMMETRIC ENGINEERING AND REMOTE SENSING LA English DT Article ID LAKE-MICHIGAN; QUALITY AB Airborne multispectral data and models of the light interaction with water were employed for general assessment of river bottom soil types and water depths in the study area. This required analyses of scanner data using multivariate pattern recognition techniques. Subsequent radiometric modeling and analyses of field data resulted in determination of class identities and creation of bottom type and water depth thematic maps from scanner data. Accuracy assessments indicated that the effort produced very good identification of five general bottom sediment types (85 percent) and general water depths (95 percent). C1 US EPA,ENVIRONM MONITORING SYST LAB,LAS VEGAS,NV 89193. USA,CORPS ENGINEERS,N CENT DIV,CHICAGO,IL 60606. RP LYON, JG (reprint author), OHIO STATE UNIV,DEPT CIVIL ENGN,COLUMBUS,OH 43210, USA. NR 20 TC 42 Z9 42 U1 0 U2 2 PU AMER SOC PHOTOGRAMMETRY PI BETHESDA PA 5410 GROSVENOR LANE SUITE 210, BETHESDA, MD 20814-2160 SN 0099-1112 J9 PHOTOGRAMM ENG REM S JI Photogramm. Eng. Remote Sens. PD JUL PY 1992 VL 58 IS 7 BP 951 EP 956 PG 6 WC Geography, Physical; Geosciences, Multidisciplinary; Remote Sensing; Imaging Science & Photographic Technology SC Physical Geography; Geology; Remote Sensing; Imaging Science & Photographic Technology GA JA634 UT WOS:A1992JA63400002 ER PT J AU ENGLUND, JC BOWDEN, CM AF ENGLUND, JC BOWDEN, CM TI SPONTANEOUS GENERATION OF PHASE WAVES AND SOLITONS IN STIMULATED RAMAN-SCATTERING .2. QUANTUM STATISTICS OF RAMAN-SOLITON GENERATION SO PHYSICAL REVIEW A LA English DT Article ID FLUCTUATIONS; NOISE AB The formalism of Englund and Bowden [Phys. Rev. A 42, 2870 (1990)] is used to conduct a detailed investigation into the statistics of spontaneously generated Raman solitons and their origin in phase waves. Two approaches are adopted. In one, a Monte Carlo simulation of the stochastic differential equations describing stimulated Raman scattering is carried out, with quantum noise entering through the Stokes vacuum. The other involves determining analytically the field statistics in the quantum-initiation regime, finding the corresponding phase-wave statistics, and determining numerically the class of phase waves that appear in the nonlinear regime as solitons. Computations involving quasi-Gaussian and rectangular pump-pulse profiles consistently indicate soliton yields of roughly 10% and 4%, respectively; differences in the distributions of soliton delay times and peak intensities are also indicated. The Monte Carlo method is adapted to the experimental parameter values of MacPherson et al. [Phys. Rev. A 40, 6745 (1989)], and gives yields and distributions in good accord with the experiment. C1 USA,MISSILE COMMAND,CTR RES DEV & ENGN,WEAP SCI DIRECTORATE,REDSTONE ARSENAL,AL 35898. RP ENGLUND, JC (reprint author), UNIV TEXAS,CTR APPL OPT,POB 830688,RICHARDSON,TX 75083, USA. NR 17 TC 27 Z9 27 U1 0 U2 1 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1050-2947 J9 PHYS REV A JI Phys. Rev. A PD JUL 1 PY 1992 VL 46 IS 1 BP 578 EP 591 DI 10.1103/PhysRevA.46.578 PG 14 WC Optics; Physics, Atomic, Molecular & Chemical SC Optics; Physics GA JC558 UT WOS:A1992JC55800074 ER PT J AU BOWDEN, CM SUNG, CC PETHEL, SD RITCHIE, AB AF BOWDEN, CM SUNG, CC PETHEL, SD RITCHIE, AB TI CLASSICAL DYNAMICS OF STRONG-FIELD IONIZATION SO PHYSICAL REVIEW A LA English DT Article ID HYDROGEN-ATOM; LASER FIELDS; SUPERINTENSE; OSCILLATOR AB We have used classical dynamics to study high-field-intensity ionization of atoms for various parameters and different potentials. The numerical calculations establish evidence that the ionization probability P vanishes in the limit of large field amplitude and small Kramer's parameter A/omega(2), where A is the field amplitude and omega is the frequency. We also show that the reported suppression of P for large values of A at fixed frequency-omega in quantum dynamics is consistent results from the corresponding classical ensemble, depending upon the potential, and within the context of comparison. These results, combined with other data, indicate that the classical-ensemble initial conditions, together with the modulation of the potential by the externally applied field, play a significant role in the classical picture of photoionization. C1 LAWRENCE BERKELEY LAB,BERKELEY,CA 94720. RP BOWDEN, CM (reprint author), USA,MISSILE COMMAND,CTR RES DEV & ENGN,WEAP SCI DIRECTORATE,AMSMI RD WS ST,REDSTONE ARSENAL,AL 35898, USA. NR 18 TC 12 Z9 12 U1 0 U2 0 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1050-2947 J9 PHYS REV A JI Phys. Rev. A PD JUL 1 PY 1992 VL 46 IS 1 BP 592 EP 596 DI 10.1103/PhysRevA.46.592 PG 5 WC Optics; Physics, Atomic, Molecular & Chemical SC Optics; Physics GA JC558 UT WOS:A1992JC55800075 ER PT J AU BOWDEN, CM PETHEL, SD SUNG, CC ENGLUND, JC AF BOWDEN, CM PETHEL, SD SUNG, CC ENGLUND, JC TI MULTICOLOR PHOTOIONIZATION AND CLASSICAL DYNAMICS SO PHYSICAL REVIEW A LA English DT Article ID DRIVEN MORSE OSCILLATOR; QUANTUM-THEORY; FIELD; CHAOS; LOCALIZATION; IONIZATION AB We use classical-ensemble dynamics to study multicolor, laser-field-induced, atomic photoionization from the ground state. It is shown that multicolor laser excitation can enhance ionization, a trend that is shown to persist for two distinct one-dimensional potentials. Maximum Lyapunov exponents and corresponding power spectra for bound orbits are used to illustrate that although chaotic temporal evolution may be manifest in predissociation dynamics, it is not a sufficient condition for dissociation. Correlation is obtained between the magnitude of the maximum Lyapunov exponent and the tendency to ionization among neighboring trajectories. C1 UNIV TEXAS,CTR APPL OPT,RICHARDSON,TX 75083. UNIV ALABAMA,DEPT PHYS,HUNTSVILLE,AL 35899. RP BOWDEN, CM (reprint author), USA,MISSILE COMMAND,CTR RES DEV & ENGN,WEAP SCI DIRECTORATE,AMSMI RD WS ST,REDSTONE ARSENAL,AL 35898, USA. NR 9 TC 4 Z9 4 U1 1 U2 2 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1050-2947 J9 PHYS REV A JI Phys. Rev. A PD JUL 1 PY 1992 VL 46 IS 1 BP 597 EP 602 DI 10.1103/PhysRevA.46.597 PG 6 WC Optics; Physics, Atomic, Molecular & Chemical SC Optics; Physics GA JC558 UT WOS:A1992JC55800076 ER PT J AU DOWLING, JP BOWDEN, CM AF DOWLING, JP BOWDEN, CM TI ATOMIC EMISSION RATES IN INHOMOGENEOUS-MEDIA WITH APPLICATIONS TO PHOTONIC BAND STRUCTURES SO PHYSICAL REVIEW A LA English DT Article ID INHIBITED SPONTANEOUS EMISSION; QUANTUM ELECTRODYNAMICS; PARTICLES AB There has been a great deal of interest in periodic dielectric materials that exhibit photonic band structures. One of the more interesting features of such a substance is its ability to alter the emission rate of probe atoms embedded in the periodic lattice. Large enhancements and complete inhibition of emission rates can be obtained. It has been known for some time that the influence of a cavity on atomic emission is essentially a classical effect. Hence, we develop a general classical treatment of radiation rates in an inhomogeneous medium. Our results agree with those of a fully quantum calculation, and are applied to a simple scalar model of a dipole in a one-dimensional periodic lattice of the Kronig-Penney type. RP DOWLING, JP (reprint author), USA,MISSILE COMMAND,CTR RES DEV & ENGN,WEAP SCI DIRECTORATE,AMSMI RD WS ST,REDSTONE ARSENAL,AL 35898, USA. RI DOWLING, JONATHAN/L-2749-2013 NR 28 TC 156 Z9 157 U1 0 U2 4 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1050-2947 J9 PHYS REV A JI Phys. Rev. A PD JUL 1 PY 1992 VL 46 IS 1 BP 612 EP 622 DI 10.1103/PhysRevA.46.612 PG 11 WC Optics; Physics, Atomic, Molecular & Chemical SC Optics; Physics GA JC558 UT WOS:A1992JC55800078 ER PT J AU MILLER, M PAN, SK AF MILLER, M PAN, SK TI THE EFFECTS OF PULSE PLATING ON LOW-CONTRACTION CHROMIUM ELECTRODEPOSITS SO PLATING AND SURFACE FINISHING LA English DT Article AB Pulse plating of low-contraction (LC) chromium using low pulse frequencies (less than 50 Hz) and high pulse frequencies (greater than 90 Hz) was evaluated and compared to direct-current-plated LC chromium, with respect to microstructure and mechanical properties. Low-frequency pulse plating significantly increases the hardness and cathode current efficiency (CCE) over dc-plated LC electrodeposits, but results in lower tensile strengths. High-frequency pulse plating produces poor quality deposits with lower hardness, CCE, and ultimate tensile strengths (UTS) than those obtained by d-c plating. RP MILLER, M (reprint author), USA,ARMAMENT RES,CTR DEV & ENGN,BENET LABS,DIV RES,WATERVLIET ARSENAL,WATERVLIET,NY 12189, USA. NR 10 TC 0 Z9 0 U1 0 U2 0 PU AMER ELECTROPLATERS SOC INC PI ORLANDO PA 12644 RESEARCH PKWY, ORLANDO, FL 32826-3298 SN 0360-3164 J9 PLAT SURF FINISH JI Plat. Surf. Finish. PD JUL PY 1992 VL 79 IS 7 BP 49 EP 56 PG 8 WC Metallurgy & Metallurgical Engineering; Materials Science, Coatings & Films SC Metallurgy & Metallurgical Engineering; Materials Science GA JD249 UT WOS:A1992JD24900017 ER PT J AU GUO, ZM LIU, CT PETERS, CJ AF GUO, ZM LIU, CT PETERS, CJ TI POSSIBLE INVOLVEMENT OF ENDOGENOUS BETA-ENDORPHIN IN THE PATHOPHYSIOLOGICAL MECHANISMS OF PICHINDE VIRUS-INFECTED GUINEA-PIGS SO PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE LA English DT Article ID CEREBROSPINAL-FLUID; OPIOID-PEPTIDES; SHOCK; BRAIN; RATS; HEART; DOGS AB Previously, we demonstrated that naloxone, an opiate antagonist, prolonged survival of strain 13 guinea pigs infected with Pichinde virus. Thus, endogenous opiates may be involved in the pathogenesis of this viral disease. To determine whether endogenous opiate levels were affected by Pichinde viral infection, beta-endorphin concentrations in plasma and cerebrospinal fluid (CSF) of normal and infected strain 13 guinea pigs were measured by radioimmunoassay. Cerebrospinal fluid beta-endorphin concentrations were 78.0 +/- 13.2 pg/ml on postinoculation day (PID) 7, 59.0 +/- 5.6 pg/ml on PID 12, and 58.8 +/- 5.4 pg/ml on PID 14. These values were significantly higher than baseline levels of CSF beta-endorphin: 30.8 +/- 1.9 pg/ml. Plasma beta-endorphin concentrations of infected animals increased significantly to 202.1 +/- 17.9 pg/ml on PID 7 and to 154.2 +/- 21.4 pg/ml on PID 12 from a mean baseline value of 84.2 +/- 13.1 pg/ml. After a primer intravenous injection of beta-endorphin (10, 15, or 30-mu-g/kg), followed by constant infusion of beta-endorphin (15, 45, or 90-mu-g/kg.hr) to control noninfected guinea pigs, heart rate (except with the lowest dose) and mean blood pressure decreased markedly. Under these experimental conditions, concentrations of plasma and CSF beta-endorphin increased simultaneously with different magnitude. Because both Pichinde viral infection and beta-endorphin administration produced a similar trend of cardiovascular disturbances, leading to hypotension and bradycardia, increased concentrations of plasma and CSF beta-endorphin may play a partial role in the pathophysiological mechanisms of Pichinde virus infection. C1 USA,MED RES INST INFECT DIS,DEPT CLIN & EXPTL PHYSIOL,DIV DIS ASSESSMENT,FREDERICK,MD 21701. NR 44 TC 5 Z9 5 U1 0 U2 0 PU BLACKWELL SCIENCE INC PI MALDEN PA 350 MAIN ST, MALDEN, MA 02148 SN 0037-9727 J9 P SOC EXP BIOL MED JI Proc. Soc. Exp. Biol. Med. PD JUL PY 1992 VL 200 IS 3 BP 343 EP 348 PG 6 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA HZ843 UT WOS:A1992HZ84300007 PM 1319583 ER PT J AU KRANSDORF, MJ SWEET, DE BUETOW, PC GIUDICI, MAI MOSER, RP AF KRANSDORF, MJ SWEET, DE BUETOW, PC GIUDICI, MAI MOSER, RP TI GIANT-CELL TUMOR IN SKELETALLY IMMATURE PATIENTS SO RADIOLOGY LA English DT Article DE BONE NEOPLASMS; BONE NEOPLASMS, DIAGNOSIS ID ANEURYSMAL BONE-CYST; DISTAL END; SECONDARY AB The radiographs and clinical and surgical histories of 50 skeletally immature patients with histologically verified giant cell tumor (GCT) of the long and short tubular bones were retrospectively studied to determine the prevalence, location within bone (eg, epiphysis, metaphysis), skeletal distribution, radiographic appearance, and pathogenesis of GCTs. Skeletal immaturity was determined radiographically by the presence of open epiphyses. Patients were selected from a group of 876 patients who were seen in consultation with documented GCT of the tubular bones. Approximately 5.7% of all GCTs occurred in the skeletally immature (this rate must be viewed with caution due to the selection bias inherent in any referral population). The lesions almost invariably involved the metaphysis. The tibia was the most commonly affected site, representing approximately 26% of cases. All were geographic lytic lesions, with margins ranging from sclerotic to ill defined. An expanded (widened), remodeled bone contour was frequently encountered. Approximately 56% of lesions were solid or solid with cystic change; the remaining 44% were predominantly cystic. C1 ARMED FORCES INST PATHOL,DEPT ORTHOPED PATHOL,WASHINGTON,DC 20306. WALTER REED ARMY MED CTR,DEPT RADIOL,WASHINGTON,DC 20307. PENN STATE UNIV,MILTON S HERSHEY MED CTR,DEPT RADIOL,HERSHEY,PA 17033. UNIFORMED SERV UNIV HLTH SCI,DEPT RADIOL & NUCL MED,BETHESDA,MD 20814. RP KRANSDORF, MJ (reprint author), ARMED FORCES INST PATHOL,DEPT RADIOL PATHOL,WASHINGTON,DC 20306, USA. NR 27 TC 39 Z9 44 U1 0 U2 0 PU RADIOLOGICAL SOC NORTH AMER PI EASTON PA 20TH AND NORTHAMPTON STS, EASTON, PA 18042 SN 0033-8419 J9 RADIOLOGY JI Radiology PD JUL PY 1992 VL 184 IS 1 BP 233 EP 237 PG 5 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA HZ682 UT WOS:A1992HZ68200047 PM 1609086 ER PT J AU BAUMGARTEN, RK AF BAUMGARTEN, RK TI LABELING OF BUPIVACAINE SOLUTIONS SO REGIONAL ANESTHESIA LA English DT Letter RP BAUMGARTEN, RK (reprint author), BROOKE ARMY MED CTR,DEPT SURG,ANESTHESIA & OPERAT SERV,FT SAM HOUSTON,TX 78234, USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS PI NEW YORK PA 650 AVENUE OF THE AMERICAS, NEW YORK, NY 10011 SN 0146-521X J9 REGION ANESTH JI Reg. Anesth. PD JUL-AUG PY 1992 VL 17 IS 4 BP 240 EP 241 PG 2 WC Anesthesiology SC Anesthesiology GA JH932 UT WOS:A1992JH93200015 PM 1515395 ER PT J AU GARCIA, JP DERENIAK, EL SHEPARD, SM AF GARCIA, JP DERENIAK, EL SHEPARD, SM TI HIGH-SPEED INFRARED CAMERA SO REVIEW OF SCIENTIFIC INSTRUMENTS LA English DT Article ID CCD AB We have developed a staring-mode, high-speed infrared camera based on a RCA 160 X 244 PtSi Schottky-barrier charge-coupled device image sensor. The camera uses a unique method to achieve greater temporal resolution of rapidly varying thermal phenomena in the 3-5-mu-m band. Rather than increase the imager's frame rate, we decrease the image integration time while maintaining a frame rate that is compatible with standard RS-170 video. This technique allows us to display and record repetitive events that occur at frequencies up to 5 kHz with conventional video equipment. In this article we describe the theory and operation of this system. C1 USA,TACOM,WARREN,MI 48098. RP GARCIA, JP (reprint author), UNIV ARIZONA,CTR OPT SCI,TUCSON,AZ 85721, USA. NR 6 TC 2 Z9 2 U1 0 U2 3 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0034-6748 J9 REV SCI INSTRUM JI Rev. Sci. Instrum. PD JUL PY 1992 VL 63 IS 7 BP 3662 EP 3665 DI 10.1063/1.1143594 PG 4 WC Instruments & Instrumentation; Physics, Applied SC Instruments & Instrumentation; Physics GA JC048 UT WOS:A1992JC04800019 ER PT J AU CHU, JN KO, FK SONG, JW AF CHU, JN KO, FK SONG, JW TI TIME-DEPENDENT MECHANICAL-PROPERTIES OF 3-D BRAIDED GRAPHITE PEEK COMPOSITES SO SAMPE QUARTERLY-SOCIETY FOR THE ADVANCEMENT OF MATERIAL AND PROCESS ENGINEERING LA English DT Article AB Poly(ether-ether-ketone) or PEEK, was developed as a high performance engineering material. In this study, 3-D braided AS4 graphite/PEEK (graphite/PEEK) composites were preformed and processed to investigate the combined performance of this new system. These manufactured composites were then characterized, using matrix digestion and wide angle x- ray diffraction, to determine their fiber volume fractions and degrees of crystallinity. After physical characterization, the mechanical response of these composites were evaluated at various temperatures. Experimental results from tensile measurements are compared to a fabric geometry model (FGM). This model predicts tensile strength based upon fiber and matrix properties, fiber volume fraction, and braiding angle. The model and experimental results are given here, and are in good agreement with each other. In order to study the time-dependent mechanical properties of these 3-D braided graphite/PEEK composites, their stress relaxation and dynamic mechanical properties were evaluated. The dynamic mechanical properties of PEEK composites are compared to short fiber and continuous fiber reinforced PEEK composites to determine the effects of fiber geometry. C1 USA,NATICK RES DEV & ENGN CTR,NATICK,MA 01760. RP CHU, JN (reprint author), DREXEL UNIV,FIBROUS MAT RES CTR,PHILADELPHIA,PA 19104, USA. NR 19 TC 3 Z9 3 U1 0 U2 0 PU SAMPE PUBLISHERS PI COVINA PA 1161 PARKVIEW DRIVE, COVINA, CA 91722 SN 0036-0821 J9 SAMPE QUART PD JUL PY 1992 VL 23 IS 4 BP 14 EP 19 PG 6 WC Engineering, Multidisciplinary; Materials Science, Multidisciplinary SC Engineering; Materials Science GA JE350 UT WOS:A1992JE35000004 ER PT J AU COBB, PW LEMAISTRE, CF AF COBB, PW LEMAISTRE, CF TI THERAPEUTIC USE OF IMMUNOTOXINS SO SEMINARS IN HEMATOLOGY LA English DT Article; Proceedings Paper CT SYMP ON IVIG : CURRENT ROLE IN BONE MARROW TRANSPLANT, MALIGNANCY, AND IMMUNE HEMATOLOGIC DISORDERS CY OCT 10-13, 1990 CL SCOTTSDALE, AZ SP SANDOZ PHARM ID VERSUS-HOST DISEASE; A-CHAIN IMMUNOTOXIN; BONE-MARROW TRANSPLANTATION; INTERLEUKIN-2 FUSION PROTEIN; DIPHTHERIA-TOXIN; PHASE-I; MONOCLONAL-ANTIBODIES; GRAFT; RICIN; LEUKEMIA C1 UNIV TEXAS,HLTH SCI CTR,DEPT MED,DIV HEMATOL,7703 FLOYD CURL DR,SAN ANTONIO,TX 78284. BROOKE ARMY MED CTR,HEMATOL ONCOL SERV,FT SAM HOUSTON,TX 78234. NR 50 TC 18 Z9 19 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0037-1963 J9 SEMIN HEMATOL JI Semin. Hematol. PD JUL PY 1992 VL 29 IS 3 SU 2 BP 6 EP 13 PG 8 WC Hematology SC Hematology GA JC362 UT WOS:A1992JC36200002 PM 1509295 ER PT J AU SMITH, TT AF SMITH, TT TI FORT-INGE AND TEXAS FRONTIER MILITARY OPERATIONS, 1849-1869 SO SOUTHWESTERN HISTORICAL QUARTERLY LA English DT Article RP SMITH, TT (reprint author), US MIL ACAD,MIL HIST,W POINT,NY 10996, USA. NR 84 TC 4 Z9 4 U1 0 U2 0 PU TEXAS STATE HIST ASSN PI AUSTIN PA 2/306 RICHARDSON HALL UNIV STATION, AUSTIN, TX 78712 SN 0038-478X J9 SOUTHWEST HIST QUART JI Southw. Hist. Q. PD JUL PY 1992 VL 96 IS 1 BP 1 EP 25 PG 25 WC History SC History GA JH756 UT WOS:A1992JH75600001 ER PT J AU WRIGHT, B AF WRIGHT, B TI HANGING SAM - A MILITARY BIOGRAPHY OF WILLIAMS,SAMUEL,T. - FROM VILLA,PANCHO TO VIETNAM - MEYER,HJ SO SOUTHWESTERN HISTORICAL QUARTERLY LA English DT Book Review RP WRIGHT, B (reprint author), USA,CTR AVIAT,FT RUCKER,AL 36360, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU TEXAS STATE HIST ASSN PI AUSTIN PA 2/306 RICHARDSON HALL UNIV STATION, AUSTIN, TX 78712 SN 0038-478X J9 SOUTHWEST HIST QUART JI Southw. Hist. Q. PD JUL PY 1992 VL 96 IS 1 BP 156 EP 157 PG 2 WC History SC History GA JH756 UT WOS:A1992JH75600033 ER PT J AU DYSART, SH SWENGEL, RM VANDAM, BE AF DYSART, SH SWENGEL, RM VANDAM, BE TI ANEURYSMAL BONE-CYST OF A THORACIC VERTEBRA - TREATMENT BY SELECTIVE ARTERIAL EMBOLIZATION AND EXCISION SO SPINE LA English DT Note C1 WALTER REED ARMY MED CTR,ORTHOPAED SERV,WASHINGTON,DC 20307. NR 0 TC 17 Z9 17 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0362-2436 J9 SPINE JI SPINE PD JUL PY 1992 VL 17 IS 7 BP 846 EP 848 DI 10.1097/00007632-199207000-00022 PG 3 WC Clinical Neurology; Orthopedics SC Neurosciences & Neurology; Orthopedics GA JE345 UT WOS:A1992JE34500022 PM 1502652 ER PT J AU OLESHANSKY, MA MEYERHOFF, JL AF OLESHANSKY, MA MEYERHOFF, JL TI ACUTE CATECHOLAMINERGIC RESPONSES TO MENTAL AND PHYSICAL STRESSORS IN MAN SO STRESS MEDICINE LA English DT Article; Proceedings Paper CT 3RD CONF OF THE INTERNATIONAL SOC FOR THE INVESTIGATION OF STRESS CY JUN 07-08, 1990 CL PADOVA, ITALY SP INT SOC INVESTIGAT STRESS DE MENTAL STRESS; PHYSICAL STRESS; CATECHOLAMINES; NOREPINEPHRINE; EPINEPHRINE ID PLASMA NOREPINEPHRINE; CARDIOVASCULAR-RESPONSES; GRADED EXERCISE; EPINEPHRINE; CORTISOL AB The measurement of plasma norepinephrine (NE) and epinephrine (EPI) levels has provided a means to assess sympathetic and adrenal medullary responses to stressors. To address the issue of specificity of these responses to mental or physical stress, we measured plasma norepinephrine (NE) and epinephrine (EPI) levels in male volunteers who underwent either exhaustive graded treadmill exercise or a 30 min stressful interview. We found that graded treadmill exercise to exhaustion (mean duration of exercise 15.2 +/- 0.7 min) was associated with similar increases in both NE (239 per cent) and EPI (201 per cent) immediately after completing exercise. Elevated values rapidly returned to baseline levels after exercise. In response to the 30 min stressful interview where subjects remained seated throughout the stressor, there were smaller but highly significant increases in plasma levels of both NE (67 per cent) and EPI (82 per cent) within the first 10 min of the interview. By the last 1O min of the interview, EPI levels were already returning to baseline values while NE levels remained elevated throughout and for at least 5 min after the exam. These findings demonstrate that a stressful interview is associated with increases in both NE and EPI levels which are qualitatively similar to the responses to a physical stressor. RP OLESHANSKY, MA (reprint author), WALTER REED ARMY MED CTR,DEPT MED NEUROSCI,DIV NEUROPSYCHIAT,WASHINGTON,DC 20307, USA. NR 25 TC 16 Z9 16 U1 2 U2 4 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0748-8386 J9 STRESS MEDICINE JI Stress Med. PD JUL PY 1992 VL 8 IS 3 BP 175 EP 179 DI 10.1002/smi.2460080308 PG 5 WC Psychiatry; Psychology SC Psychiatry; Psychology GA JG043 UT WOS:A1992JG04300007 ER PT J AU MAXWELL, DM CASTRO, CA DELAHOZ, DM GENTRY, MK GOLD, MB SOLANA, RP WOLFE, AD DOCTOR, BP AF MAXWELL, DM CASTRO, CA DELAHOZ, DM GENTRY, MK GOLD, MB SOLANA, RP WOLFE, AD DOCTOR, BP TI PROTECTION OF RHESUS-MONKEYS AGAINST SOMAN AND PREVENTION OF PERFORMANCE DECREMENT BY PRETREATMENT WITH ACETYLCHOLINESTERASE SO TOXICOLOGY AND APPLIED PHARMACOLOGY LA English DT Article ID BOVINE SERUM ACETYLCHOLINESTERASE; NERVE AGENTS; TOXICITY; PROPHYLAXIS; MICE C1 WALTER REED ARMY MED CTR,DIV BIOCHEM,WASHINGTON,DC 20307. USA,MED INST CHEM DEF,DIV PHARMACOL,ABERDEEN PROVING GROUND,MD 21010. NR 25 TC 48 Z9 48 U1 0 U2 1 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0041-008X J9 TOXICOL APPL PHARM JI Toxicol. Appl. Pharmacol. PD JUL PY 1992 VL 115 IS 1 BP 44 EP 49 DI 10.1016/0041-008X(92)90365-Y PG 6 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA JC474 UT WOS:A1992JC47400006 PM 1631892 ER PT J AU WATT, G SHANKS, GD PHINTUYOTHIN, P AF WATT, G SHANKS, GD PHINTUYOTHIN, P TI PROGNOSTIC-SIGNIFICANCE OF RISES IN PARASITEMIA DURING TREATMENT OF FALCIPARUM-MALARIA SO TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID MEFLOQUINE AB Transient rises in parasitaemia occur commonly during the treatment of falciparum malaria but their prognostic significance has not been well defined. Twelve-hourly parasite counts from 133 malaria patients who were ultimately cured were therefore compared with counts from 97 therapeutic failures to determine if increase in parasitaemia was a useful early indicator of poor treatment response. Parasitaemia in both groups frequently rose during the initial 12 h of therapy (41% of all patients), but rising counts thereafter were rarer in treatment successes (P<0.01). The relative risk of treatment failure was 3.8 if the count was higher at 24 h than 12 h, rose to 7.8 for increases at 48-60 h, and was 13.7 and 19.4 for counts above admission levels at 48 h and 60 h. These data suggest a way to identify patients at high risk of treatment failure. RP WATT, G (reprint author), ARMED FORCES RES INST MED SCI,DEPT MED,BANGKOK 10400,THAILAND. NR 6 TC 14 Z9 14 U1 0 U2 0 PU ROYAL SOC TROPICAL MEDICINE PI LONDON PA MANSON HOUSE 26 PORTLAND PLACE, LONDON, ENGLAND W1N 4EY SN 0035-9203 J9 T ROY SOC TROP MED H JI Trans. Roy. Soc. Trop. Med. Hyg. PD JUL-AUG PY 1992 VL 86 IS 4 BP 359 EP 360 DI 10.1016/0035-9203(92)90217-Z PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA JM180 UT WOS:A1992JM18000003 PM 1440800 ER PT J AU GOLDINGER, JM HONG, SK CLAYBAUGH, JR NIU, AKC GUTMAN, SI MOON, RE BENNETT, PB AF GOLDINGER, JM HONG, SK CLAYBAUGH, JR NIU, AKC GUTMAN, SI MOON, RE BENNETT, PB TI RENAL RESPONSES DURING A DRY SATURATION DIVE TO 450 MSW SO UNDERSEA BIOMEDICAL RESEARCH LA English DT Article DE KIDNEY; SATURATION DIVE; TRIMIX ID PRESSURE; DIURESIS; ATA AB Four subjects were compressed to a simulated depth of 450 msw (46 bar) for 37 days in the main research chamber of the German underwater simulator diving facility at the GKSS Research Center, Geesthacht. The ambient gas was trimix. Urine was collected at 0700, 1300, and 1900 h each day for analysis of Na+, K+, volume, osmolality, and creatinine. Urine, antidiuretic hormone (ADH), and aldosterone were analyzed separately. Daily fluid, Na+, and K+ intake were analyzed throughout the dive. The aim of the investigation was to confirm the existence of a diuresis and natriuresis which had been observed in earlier saturation dives to 31 atm abs using He-O2. A significant diuresis was observed during compression despite a decrease in fluid intake. After compression the diuresis decreased somewhat but remained significantly above precompression control levels during the entire hyperbaric exposure. No significant change in fluid intake was observed. Daily Na+ and K+ excretion increased significantly during compression, which was accompanied by a significant increase in nocturnal excretion of Na+ and K+. Daily intake of Na+ and K+ decreased throughout the dive. Daily urine ADH decreased immediately upon compression and was associated with a parallel decrease in urine osmolality. In contrast, urinary aldosterone excretion exhibited no change during the dive despite the increase in Na+ and K+ excretion and decrease in Na+ intake. C1 TRIPLER ARMY MED CTR,HONOLULU,HI 96859. VET ADM MED CTR,BUFFALO,NY 14215. DUKE UNIV,DURHAM,NC 27706. RP GOLDINGER, JM (reprint author), SUNY BUFFALO,DEPT PHYSIOL,BUFFALO,NY 14260, USA. NR 14 TC 7 Z9 9 U1 0 U2 0 PU UNDERSEA & HYPERBARIC MEDICAL SOC INC PI KENSINGTON PA 10531 METROPOLITAN AVE, KENSINGTON, MD 20895 SN 0093-5387 J9 UNDERSEA BIOMED RES PD JUL PY 1992 VL 19 IS 4 BP 287 EP 293 PG 7 WC Oceanography SC Oceanography GA JH053 UT WOS:A1992JH05300006 PM 1496753 ER PT J AU CLAYBAUGH, JR GOLDINGER, JM MOON, RE FAWCETT, TA EXPOSITO, AG HONG, SK HOLTHAUS, J BENNETT, PB AF CLAYBAUGH, JR GOLDINGER, JM MOON, RE FAWCETT, TA EXPOSITO, AG HONG, SK HOLTHAUS, J BENNETT, PB TI URINARY VASOPRESSIN AND ALDOSTERONE AND PLASMA-VOLUME DURING A SATURATION DIVE TO 450 M SO UNDERSEA BIOMEDICAL RESEARCH LA English DT Article DE VASOPRESSIN; ALDOSTERONE; CIRCADIAN RHYTHM; HYPERBARIA; URINE OSMOLALITY; NATRIURESIS; PLASMA VOLUME ID SEADRAGON-VI; RESPONSES; DIURESIS; 31-ATA; HUMANS AB Urinary vasopressin (VP), aldosterone (ALDO), osmotic substances, sodium excretion, and plasma volume were assessed in 4 healthy male divers during 2 predive control days, 2 compression days, 6 days at 46 atm abs, and 26 days of decompression with stops at 37 and 27 atm abs. At pressure the ambient ps was trimix (0.5 atm abs O2:5% N2:remainder He). All urine was collected throughout the dive. Samples were divided into daytime (0700-1900) and nighttime (1900-0700). Indocyanine green dye dilution was used to determine plasma volume at predive 1, 46, and 24 atm abs. In agreement with previous dives at 31 atm abs, there was a decrease in VP excretion during compression lasting until return to 1 atm abs (P < 0.05). Also similar to the shallower dives at 31 atm abs, the normal diurnal pattern of VP excretion, daytime higher than nighttime (P < 0.05), disappeared at pressure. Urine osmolality showed alterations compatible with responses to VP. In contrast to previous studies at 31 atm abs, but in agreement with a previous study at 49.5 atm abs, there was no sustained increase in urinary ALDO excretion and only a transient natriuresis during the compression phase, followed by a reduced sodium excretion. In confirmation of earlier conclusions from indirect evidence, direct measurements of plasma volume indicated a reduction of about 20% (P < 0.05) at 46 atm abs which remained reduced after decompression to 24 atm abs. C1 GKSS,GUSI,GEESTHACHT,GERMANY. DUKE UNIV,DURHAM,NC 27706. SUNY BUFFALO,BUFFALO,NY 14214. RP CLAYBAUGH, JR (reprint author), TRIPLER ARMY MED CTR,HONOLULU,HI 96859, USA. FU NHLBI NIH HHS [HL 28542] NR 18 TC 7 Z9 7 U1 0 U2 0 PU UNDERSEA & HYPERBARIC MEDICAL SOC INC PI KENSINGTON PA 10531 METROPOLITAN AVE, KENSINGTON, MD 20895 SN 0093-5387 J9 UNDERSEA BIOMED RES PD JUL PY 1992 VL 19 IS 4 BP 295 EP 304 PG 10 WC Oceanography SC Oceanography GA JH053 UT WOS:A1992JH05300007 PM 1353929 ER PT J AU HOBBS, BF CHANKONG, V HAMADEH, W STAKHIV, EZ AF HOBBS, BF CHANKONG, V HAMADEH, W STAKHIV, EZ TI DOES CHOICE OF MULTICRITERIA METHOD MATTER - AN EXPERIMENT IN WATER-RESOURCES PLANNING SO WATER RESOURCES RESEARCH LA English DT Article ID UTILITY; OPTIMIZATION AB Many multiple criteria decision making methods have been proposed and applied to water planning. Their purpose is to provide information on tradeoffs among objectives and to help users articulate value judgments in a systematic, coherent, and documentable manner. The wide variety of available techniques confuses potential users, causing inappropriate matching of methods with problems. Experiments in which water planners apply more than one multicriteria procedure to realistic problems can help dispel this confusion by testing method appropriateness, ease of use, and validity. We summarize one such experiment where U.S. Army Corps of Engineers personnel used several methods to screen urban water supply plans. The methods evaluated include goal programming, ELECTRE I, additive value functions, multiplicative utility functions, and three techniques for choosing weights (direct rating, indifference tradeoff, and the analytical hierarchy process). Among the conclusions we reach are the following. First, experienced planners generally prefer simpler, more transparent methods. Additive value functions are favored. Yet none of the methods are endorsed by a majority of the participants; many preferred to use no formal method at all. Second, there is strong evidence that rating, the most commonly applied weight selection method, is likely to lead to weights that fail to represent the trade-offs that users are willing to make among criteria. Finally, we show that decisions can be as or more sensitive to the method used as to which person applies it. Therefore, if who chooses is important, then so too is how a choice is made. C1 USA,CORPS ENGN,INST WATER RESOURCES,FT BELVOIR,VA 22060. RP HOBBS, BF (reprint author), CASE WESTERN RESERVE UNIV,DEPT SYST ENGN,CLEVELAND,OH 44106, USA. RI Hobbs, Benjamin/A-3291-2010 NR 45 TC 59 Z9 60 U1 1 U2 7 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 SN 0043-1397 J9 WATER RESOUR RES JI Water Resour. Res. PD JUL PY 1992 VL 28 IS 7 BP 1767 EP 1779 DI 10.1029/92WR00712 PG 13 WC Environmental Sciences; Limnology; Water Resources SC Environmental Sciences & Ecology; Marine & Freshwater Biology; Water Resources GA JC483 UT WOS:A1992JC48300002 ER PT J AU SULLIVAN, JM ONEILL, K AF SULLIVAN, JM ONEILL, K TI APPLICATION OF INFINITE ELEMENTS TO PHASE-CHANGE SITUATIONS ON DEFORMING MESHES SO INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN ENGINEERING LA English DT Article ID SIMULATION; BOUNDARY AB In recent years progress has been made in applying moving and deforming mesh systems to phase change problems. This allows the numerical attention where it is needed, near the migrating phase change zone. In spatially unbounded problems one hopes that numerically finite outer boundaries either escape significant activity or are automatically pushed further away as activity nears. Not infrequently this approach fails. Temperature activity often spreads more rapidly than phase change, thereby reaching far boundaries; stretching of the mesh by movement of far boundaries can challenge mesh control and cause ill-conditioning. In this paper the advantages of time dependent mesh adaption are enhanced by the joining of a new formulation for infinite elements to far boundaries. This is accomplished through a co-ordinate transformation within the framework of conventional 2-D quadratic, biquadratic, and linear-quadratic elements. Standard 2 by 2 Gauss-Legendre quadrature suffices throughout and normal Galerkin finite element features are undisturbed, including strict conservation of energy. The formulation is independent of global co-ordinates, entails no restrictions on the unknown function and should be applicable to other problem types. All test cases on quadrilateral and triangular grids show very significant improvements with infinite elements relative to comparable solution systems using strictly finite grids. C1 USA,COLD REG RES & ENGN LAB,HANOVER,NH 03755. RP SULLIVAN, JM (reprint author), WORCESTER POLYTECH INST,DEPT MECH ENGN,WORCESTER,MA 01609, USA. NR 22 TC 3 Z9 3 U1 0 U2 0 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0029-5981 J9 INT J NUMER METH ENG JI Int. J. Numer. Methods Eng. PD JUN 30 PY 1992 VL 33 IS 9 BP 1861 EP 1874 DI 10.1002/nme.1620330907 PG 14 WC Engineering, Multidisciplinary; Mathematics, Interdisciplinary Applications SC Engineering; Mathematics GA HV591 UT WOS:A1992HV59100006 ER PT J AU POSNER, GH OH, CH GERENA, L MILHOUS, WK AF POSNER, GH OH, CH GERENA, L MILHOUS, WK TI EXTRAORDINARILY POTENT ANTIMALARIAL COMPOUNDS - NEW, STRUCTURALLY SIMPLE, EASILY SYNTHESIZED, TRICYCLIC 1,2,4-TRIOXANES SO JOURNAL OF MEDICINAL CHEMISTRY LA English DT Article ID SOLUBLE DIHYDROARTEMISININ DERIVATIVES; ARTEMISINIC ACID; STEREOCHEMICAL ASPECTS; QINGHAOSU ARTEMISININ; RESISTANT MALARIA; ANTI-MALARIAL; ANALOGS; CONVERSION; DRUG; RESURGENCE AB New, racemic, tricyclic trioxane alcohol 3 was designed and synthesized as a structurally simple analog of clinically useful, tetracyclic, antimalarial artemisinin. A series of 20 ester and ether derivatives of alcohol 3 were prepared easily, without destruction of the essential trioxane system. Chemical structure-antimalarial activity for each derivative was evaluated in vitro against chloroquine-resistant and chloroquine-sensitive Plasmodium falciparum parasites. Many of these derivatives were highly efficacious; carboxylate ester 9f, carbamate ester 10a, and sulfonate ester 12a had antimalarial potency similar to that of artemisinin, and carboxylate esters 9b and 9d, carbamate esters 10b and 10c, and phosphate esters 11a-c had antimalarial potency up to 7 times higher than that of artemisinin. Several of these most active analogs (e.g., carboxylate 9b and carbamates 10a and 10c) are stable crystalline solids, a feature of considerable practical value for any new drug candidate. C1 WALTER REED ARMY MED CTR,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307. RP POSNER, GH (reprint author), JOHNS HOPKINS UNIV,DEPT CHEM,BALTIMORE,MD 21218, USA. NR 47 TC 92 Z9 96 U1 0 U2 4 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0022-2623 J9 J MED CHEM JI J. Med. Chem. PD JUN 26 PY 1992 VL 35 IS 13 BP 2459 EP 2467 DI 10.1021/jm00091a014 PG 9 WC Chemistry, Medicinal SC Pharmacology & Pharmacy GA JB463 UT WOS:A1992JB46300014 PM 1619620 ER PT J AU PIMENTA, PFP TURCO, SJ MCCONVILLE, MJ LAWYER, PG PERKINS, PV SACKS, DL AF PIMENTA, PFP TURCO, SJ MCCONVILLE, MJ LAWYER, PG PERKINS, PV SACKS, DL TI STAGE-SPECIFIC ADHESION OF LEISHMANIA PROMASTIGOTES TO THE SANDFLY MIDGUT SO SCIENCE LA English DT Article ID MAJOR PROMASTIGOTES; TRYPANOSOMA-CRUZI; LIPOPHOSPHOGLYCAN; METACYCLOGENESIS; IDENTIFICATION; GLYCOCONJUGATE; ATTACHMENT; GUT AB Although leishmaniasis is transmitted to humans almost exclusively by the bite of infected phlebotomine sandflies, little is known about the molecules controlling the survival and development of Leishmania parasites in their insect vectors. Adhesion of Leishmania promastigotes to the midgut epithelial cells of the sandfly was found to be an inherent property of noninfective-stage promastigotes, which was lost during their transformation to metacyclic forms, thus permitting the selective release of infective-stage parasites for subsequent transmission by bite. Midgut attachment and release was found to be controlled by specific developmental modifications in terminally exposed saccharides on lipophosphoglycan, the major surface molecule on Leishmania promastigotes. C1 NIAID,PARASIT DIS LAB,BLDG 4,ROOM 126,BETHESDA,MD 20892. WALTER REED ARMY MED CTR,DEPT ENTOMOL,WASHINGTON,DC 20307. UNIV KENTUCKY,MED CTR,DEPT BIOCHEM,LEXINGTON,KY 40536. UNIV DUNDEE,DEPT BIOCHEM,DUNDEE DD1 4HN,SCOTLAND. NR 26 TC 178 Z9 180 U1 0 U2 21 PU AMER ASSOC ADVANCEMENT SCIENCE PI WASHINGTON PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 SN 0036-8075 J9 SCIENCE JI Science PD JUN 26 PY 1992 VL 256 IS 5065 BP 1812 EP 1815 DI 10.1126/science.1615326 PG 4 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA JA434 UT WOS:A1992JA43400034 PM 1615326 ER PT J AU CHOWDHURY, DQ BARBER, PW HILL, SC AF CHOWDHURY, DQ BARBER, PW HILL, SC TI ENERGY-DENSITY DISTRIBUTION INSIDE LARGE NONABSORBING SPHERES BY USING MIE THEORY AND GEOMETRICAL-OPTICS SO APPLIED OPTICS LA English DT Article DE MIE THEORY; SCATTERING; GEOMETRICAL OPTICS ID MORPHOLOGY-DEPENDENT RESONANCES; STIMULATED BRILLOUIN-SCATTERING; MICROMETER-SIZE DROPLETS; LIQUID DROPLETS; RAMAN-SCATTERING; LASER; DISTORTION; GENERATION; EMISSION; WATER AB Mie theory and geometrical-optics ray tracing are used to obtain the distribution of electric energy density inside a nonabsorbing micrometer-sized sphere illuminated by a polarized plane wave. The Mie solution shows the multiply reflected geometrical-optics rays inside a sphere having a diameter of approximately 150 free-space wavelengths (size parameter = circumference/wavelength = 500). The geometrical-optics result shows the major features of the Mie solution and provides a physical interpretation of the electromagnetic interactions that result in the observed energy-density distributions. Both solutions show internal on-axis energy-density maxima inside the shadow surface of the sphere. The region of greatest enhanced energy density is approximately one internal wavelength in diameter and approximately twenty internal wavelengths in length. C1 USA,ATMOSPHER SCI LAB,WHITE SANDS MISSILE RANGE,NM 88002. RP CHOWDHURY, DQ (reprint author), CLARKSON UNIV,DEPT ELECT & COMP ENGN,POTSDAM,NY 13699, USA. NR 24 TC 34 Z9 34 U1 1 U2 4 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0003-6935 J9 APPL OPTICS JI Appl. Optics PD JUN 20 PY 1992 VL 31 IS 18 BP 3518 EP 3523 PG 6 WC Optics SC Optics GA HY065 UT WOS:A1992HY06500030 PM 20725320 ER PT J AU KORTE, WD AF KORTE, WD TI DETERMINATION OF HYDROXYLAMINE IN AQUEOUS-SOLUTIONS OF PYRIDINIUM ALDOXIMES BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH UV AND FLUOROMETRIC DETECTION SO JOURNAL OF CHROMATOGRAPHY LA English DT Article ID PRALIDOXIME MESYLATE AB A high-performance liquid chromatographic assay using UV and fluorescence detection was developed that monitored hydroxylamine as the vanillin oxime derivative while simultaneously monitoring concentrations of a complex mixture of a pyridinium aldoxime and its degradation products. The technique should be useful for measuring hydroxylamine levels in other aqueous systems. C1 USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010. NR 20 TC 21 Z9 21 U1 0 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0021-9673 J9 J CHROMATOGR PD JUN 19 PY 1992 VL 603 IS 1-2 BP 145 EP 150 DI 10.1016/0021-9673(92)85355-W PG 6 WC Chemistry, Analytical SC Chemistry GA JB262 UT WOS:A1992JB26200016 ER PT J AU ACTON, N ROTH, RJ AF ACTON, N ROTH, RJ TI ON THE CONVERSION OF DIHYDROARTEMISINIC ACID INTO ARTEMISININ SO JOURNAL OF ORGANIC CHEMISTRY LA English DT Article ID STEREOSPECIFIC SYNTHESIS; ALLYLIC HYDROPEROXIDES; QINGHAOSU; ARTEANNUIN; BIOSYNTHESIS AB Mechanistic possibilities for the title conversion are discussed. By determining the oxygen 18-induced chemical shifts in the C-13 NMR spectrum of labeled 3, some of these mechanisms can be eliminated. Minor products obtained in the oxidative conversion of 2 into 3 have been identified. C1 GEORGE MASON UNIV,DEPT CHEM,FAIRFAX,VA 22030. RP ACTON, N (reprint author), WALTER REED ARMY MED CTR,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307, USA. NR 23 TC 55 Z9 60 U1 3 U2 19 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0022-3263 J9 J ORG CHEM JI J. Org. Chem. PD JUN 19 PY 1992 VL 57 IS 13 BP 3610 EP 3614 DI 10.1021/jo00039a020 PG 5 WC Chemistry, Organic SC Chemistry GA HZ903 UT WOS:A1992HZ90300020 ER PT J AU HOGE, CW AF HOGE, CW TI SPORADIC CASES OF LEGIONNAIRES-DISEASE SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Letter RP HOGE, CW (reprint author), ARMED FORCES RES INST MED SCI,APO AP 96546,BANGKOK,THAILAND. NR 5 TC 0 Z9 0 U1 0 U2 0 PU MASS MEDICAL SOC PI BOSTON PA 10 SHATTUCK, BOSTON, MA 02115 SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD JUN 18 PY 1992 VL 326 IS 25 BP 1699 EP 1700 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA HY628 UT WOS:A1992HY62800014 PM 1588989 ER PT J AU WILLIAMS, JC PEACOCK, MG WAAG, DM KENT, G ENGLAND, MJ NELSON, G STEPHENSON, EH AF WILLIAMS, JC PEACOCK, MG WAAG, DM KENT, G ENGLAND, MJ NELSON, G STEPHENSON, EH TI VACCINES AGAINST COXIELLOSIS AND Q-FEVER - DEVELOPMENT OF A CHLOROFORM-METHANOL RESIDUE SUBUNIT OF PHASE-I COXIELLA-BURNETII FOR THE IMMUNIZATION OF ANIMALS SO ANNALS OF THE NEW YORK ACADEMY OF SCIENCES LA English DT Article ID SCN MICE; SHEEP; IMMUNITY; EXPOSURE; VACCINATION; CHALLENGE; PNEUMONIA; EWES C1 USA,MED RES INST INFECT DIS,DEPT INTRACELLULAR PATHOGENS,DIV BACTERIOL,FREDERICK,MD 21701. USA,MED RES INST INFECT DIS,DIV BIOMETR & INFORMAT MANAGEMENT,FREDERICK,MD 21701. NIAID,OFF SCI DIRECTOR,BETHESDA,MD 20892. ROCKY MT LABS,HAMILTON,MT 59840. UNIV MARYLAND,VIRGINIA MARYLAND REG COLL VET COLL,COLL PK,MD 20742. USA,MED RES INST INFECT DIS,FREDERICK,MD 21701. HOSP SICK CHILDREN,TORONTO M5G 1X8,ONTARIO,CANADA. NR 40 TC 15 Z9 15 U1 0 U2 2 PU NEW YORK ACAD SCIENCES PI NEW YORK PA 2 E 63RD ST, NEW YORK, NY 10021 SN 0077-8923 J9 ANN NY ACAD SCI JI Ann. N.Y. Acad. Sci. PD JUN 16 PY 1992 VL 653 BP 88 EP 111 DI 10.1111/j.1749-6632.1992.tb19633.x PG 24 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA JM564 UT WOS:A1992JM56400012 PM 1626897 ER PT J AU HOUSE, JA TURELL, MJ MEBUS, CA AF HOUSE, JA TURELL, MJ MEBUS, CA TI RIFT-VALLEY FEVER - PRESENT STATUS AND RISK TO THE WESTERN-HEMISPHERE SO ANNALS OF THE NEW YORK ACADEMY OF SCIENCES LA English DT Article ID VECTOR COMPETENCE; EGYPT 1977-78; SAND FLY; VIRUS; TRANSMISSION; TEMPERATURE; DIPTERA; VACCINE; EPIDEMIC; SPREAD C1 USA,MED RES INST INFECT DIS,FT DETRICK,FREDERICK,MD 21701. RP HOUSE, JA (reprint author), USDA ARS,PLUM ISL ANIM DIS CTR,NATL VET SERV LABS,FOREIGN ANIM DIS DIAGNOST LAB,GREENPORT,NY 11944, USA. NR 63 TC 32 Z9 34 U1 0 U2 0 PU NEW YORK ACAD SCIENCES PI NEW YORK PA 2 E 63RD ST, NEW YORK, NY 10021 SN 0077-8923 J9 ANN NY ACAD SCI JI Ann. N.Y. Acad. Sci. PD JUN 16 PY 1992 VL 653 BP 233 EP 242 DI 10.1111/j.1749-6632.1992.tb19652.x PG 10 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA JM564 UT WOS:A1992JM56400031 PM 1626877 ER PT J AU KENDE, M AF KENDE, M TI TREATMENT STRATEGIES FOR HUMAN ARBOVIRAL INFECTIONS APPLICABLE TO VETERINARY-MEDICINE SO ANNALS OF THE NEW YORK ACADEMY OF SCIENCES LA English DT Article ID FEVER VIRUS-INFECTION; INTERFERON-ALPHA; MICE; EFFICACY; POLY(ICLC); BETA; ACID RP KENDE, M (reprint author), USA,MED RES INST INFECT DIS,DEPT CLIN IMMUNOL,DIV MED,FT DETRICK,FREDERICK,MD 21701, USA. NR 20 TC 3 Z9 3 U1 0 U2 0 PU NEW YORK ACAD SCIENCES PI NEW YORK PA 2 E 63RD ST, NEW YORK, NY 10021 SN 0077-8923 J9 ANN NY ACAD SCI JI Ann. N.Y. Acad. Sci. PD JUN 16 PY 1992 VL 653 BP 297 EP 313 DI 10.1111/j.1749-6632.1992.tb19657.x PG 17 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA JM564 UT WOS:A1992JM56400036 PM 1626881 ER PT J AU TIGNOR, GH KENDE, M HANHAM, CA AF TIGNOR, GH KENDE, M HANHAM, CA TI CHEMOTHERAPEUTIC PREVENTION OF COMPLICATIONS CAUSED BY VACCINIA VIRUS-VECTORED IMMUNOGEN SO ANNALS OF THE NEW YORK ACADEMY OF SCIENCES LA English DT Article ID INTERFERON; INFECTION; FEVER; MICE C1 USA,MED RES INST INFECT DIS,FREDERICK,MD 21701. RP TIGNOR, GH (reprint author), YALE UNIV,SCH MED,YALE ARBOVIRUS RES UNIT,NEW HAVEN,CT 06510, USA. NR 11 TC 7 Z9 7 U1 0 U2 0 PU NEW YORK ACAD SCIENCES PI NEW YORK PA 2 E 63RD ST, NEW YORK, NY 10021 SN 0077-8923 J9 ANN NY ACAD SCI JI Ann. N.Y. Acad. Sci. PD JUN 16 PY 1992 VL 653 BP 334 EP 343 DI 10.1111/j.1749-6632.1992.tb19660.x PG 10 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA JM564 UT WOS:A1992JM56400039 PM 1626883 ER PT J AU SIDWELL, RW HUFFMAN, JH SMEE, DF GILBERT, J GESSAMAN, A PEASE, A WARREN, RP HUGGINS, J KENDE, M AF SIDWELL, RW HUFFMAN, JH SMEE, DF GILBERT, J GESSAMAN, A PEASE, A WARREN, RP HUGGINS, J KENDE, M TI POTENTIAL ROLE OF IMMUNOMODULATORS FOR TREATMENT OF PHLEBOVIRUS INFECTIONS OF ANIMALS SO ANNALS OF THE NEW YORK ACADEMY OF SCIENCES LA English DT Article ID TORO VIRUS-INFECTIONS; VALLEY FEVER VIRUS; MICE; RIBAVIRIN; INTERLEUKIN-2; INTERFERON; MODEL C1 USA,MED RES INST INFECT DIS,DEPT ANTIVIRAL STUDIES,FREDERICK,MD 21701. RP SIDWELL, RW (reprint author), UTAH STATE UNIV,INST ANTIVIRAL RES,LOGAN,UT 84322, USA. NR 30 TC 15 Z9 16 U1 0 U2 0 PU NEW YORK ACAD SCIENCES PI NEW YORK PA 2 E 63RD ST, NEW YORK, NY 10021 SN 0077-8923 J9 ANN NY ACAD SCI JI Ann. N.Y. Acad. Sci. PD JUN 16 PY 1992 VL 653 BP 344 EP 355 DI 10.1111/j.1749-6632.1992.tb19661.x PG 12 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA JM564 UT WOS:A1992JM56400040 PM 1385686 ER PT J AU WILLIAMS, JC KOCAN, KM AHL, AS KAKOMA, I GIBBS, EPJ AF WILLIAMS, JC KOCAN, KM AHL, AS KAKOMA, I GIBBS, EPJ TI 1ST BIENNIAL CONFERENCE OF THE AMERICAN-SOCIETY-OF TROPICAL-VETERINARY-MEDICINE WHICH WAS HELD BY THE AMERICAN-SOCIETY-OF-TROPICAL-VETERINARY-MEDICINE ON FEBRUARY 5-8, 1991 IN SAN-JUAN, PUERTO-RICO - PREFACE SO ANNALS OF THE NEW YORK ACADEMY OF SCIENCES LA English DT Editorial Material C1 USA,MED RES INST INFECT DIS,DEPT INTRACELLULAR PATHOGENS,DIV BACTERIOL,FREDERICK,MD 21701. NIAID,OFF SCI DIRECTOR,BETHESDA,MD 20892. OKLAHOMA STATE UNIV,COLL VET MED,DEPT VET PATHOL,STILLWATER,OK 74078. USDA,ANIM & PLANT HLTH INSPECT SERV,RISK ANAL SECT,HYATTSVILLE,MD 20782. UNIV FLORIDA,COLL VET MED,GAINESVILLE,FL 32610. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NEW YORK ACAD SCIENCES PI NEW YORK PA 2 E 63RD ST, NEW YORK, NY 10021 SN 0077-8923 J9 ANN NY ACAD SCI JI Ann. N.Y. Acad. Sci. PD JUN 16 PY 1992 VL 653 BP R11 EP R12 DI 10.1111/j.1749-6632.1992.tb19622.x PG 2 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA JM564 UT WOS:A1992JM56400001 ER PT J AU BLANEY, SM BALIS, FM GREM, J COLE, DE ADAMSON, PC POPLACK, DG AF BLANEY, SM BALIS, FM GREM, J COLE, DE ADAMSON, PC POPLACK, DG TI MODULATION OF THE CYTOTOXIC EFFECT OF CYCLOPENTENYLCYTOSINE BY ITS PRIMARY METABOLITE, CYCLOPENTENYLURIDINE SO CANCER RESEARCH LA English DT Article ID ANTITUMOR; CYTOSINE AB Cyclopentenylcytosine (CPE-C), a synthetic cytidine analogue with significant preclinical antitumor activity against both solid tumor xenografts and 1-beta-D-arabinofuranosylcytosine resistant murine leukemia cell lines, will soon enter phase I clinical trials. Unlike 1-beta-arabinofuranosylcytosine which is activated by deoxycytidine kinase, the enzyme responsible for the phosphorylation of CPE-C is uridine/cytidine kinase. Preclinical pharmacokinetic studies of CPE-C in nonhuman primates revealed that the primary route of elimination in this species was deamination to cyclopentenyluridine (CPE-U), an inhibitor of uridine/cytidine kinase. Since CPE-C is likely to be deaminated in humans, we investigated the modulating effect of CPE-U on the in vitro cytotoxicity of CPE-C in Molt-4 lymphoblasts. Concurrent exposure of cells to cytotoxic concentrations of CPE-C and 50-mu-M CPE-U resulted in the rescue of 50% of cells and exposure to CPE-U concentrations in excess of 100-mu-M resulted in the rescue of greater than 90% of cells. Progressive attenuation of the rescue effect was observed with delayed administration of CPE-U and no cells were rescued when addition of CPE-C was delayed for more than 2 h. At the intracellular level it was observed that the formation of the cytotoxic metabolite, cyclopentenylcytosine triphosphate, was blocked by increasing concentrations of CPE-U presumably secondary to inhibition of uridine/cytidine kinase by CPE-U. Although CPE-U can modulate the cytotoxic effects of CPE-C in vitro, the minimum CPE-U levels that are required for modulation coupled with the available preclinical pharmacokinetic data from nonhuman primates suggests that this modulation is not likely to impact on the antitumor effects of CPE-C in humans. C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NCI,NATL NAVAL MED CTR,MED ONCOL BRANCH,BETHESDA,MD 20899. RP BLANEY, SM (reprint author), NCI,PEDIAT BRANCH,BLDG 10,RM 13N240,9000 ROCKVILLE PIKE,BETHESDA,MD 20892, USA. NR 11 TC 7 Z9 7 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA PUBLIC LEDGER BLDG, SUITE 816, 150 S. INDEPENDENCE MALL W., PHILADELPHIA, PA 19106 SN 0008-5472 J9 CANCER RES JI Cancer Res. PD JUN 15 PY 1992 VL 52 IS 12 BP 3503 EP 3505 PG 3 WC Oncology SC Oncology GA HY054 UT WOS:A1992HY05400043 PM 1596909 ER PT J AU SERREZE, MC MASLANIK, JA REHDER, MC SCHNELL, RC KAHL, JD ANDREAS, EL AF SERREZE, MC MASLANIK, JA REHDER, MC SCHNELL, RC KAHL, JD ANDREAS, EL TI THEORETICAL HEIGHTS OF BUOYANT CONVECTION ABOVE OPEN LEADS IN THE WINTER ARCTIC PACK ICE COVER SO JOURNAL OF GEOPHYSICAL RESEARCH-OCEANS LA English DT Article ID HEAT-FLUX; SEA-ICE; POLYNYAS; COEFFICIENTS; TEMPERATURE; ENVIRONMENT; ENTRAINMENT AB A fetch-dependent boundary-layer model, driven by observed temperature sounding data, is used to examine theoretical heights of buoyant convection (H) above open leads in the wintertime pack ice of the central Arctic. Assuming wet adiabatic ascent with no entrainment or friction, H is estimated as the height at which the model-predicted equivalent potential temperature at saturation above a lead (theta(el)) intersects with the same value of equivalent potential temperature st saturation (theta(e)) derived from vertical sounding profiles. H increases with increasing lead width. For a 1000-m lead, the widest which can be reasonably expected for the central Arctic, the median value of H is approximately 1000 m, slightly below the median top of the low-level Arctic temperature inversion layer. While H shows large variability, events of convection up to 4 km, as recently observed from lidar backscatter data, appears to be fairly rare. First, these events require an open lead of at least 10,000 m. Second, while H tends to be largest under conditions of low surface wind speed, low surface temperature, and a weak low-level temperature inversion, this combination appears to be atypical of Arctic conditions. Third, while the meteorological conditions that should favor the development of open leads tend to minimize H, conditions favoring large H are also those in which any newly developed leads will quickly ice over. C1 UNIV WISCONSIN,DEPT GEOSCI,MILWAUKEE,WI 53211. USA,COLD REG RES & ENGN LAB,HANOVER,NH 03755. RP SERREZE, MC (reprint author), UNIV COLORADO,NOAA,COOPERAT INST RES ENVIRONM SCI,DIV CRYOSPHER & POLAR PROC,BOULDER,CO 80309, USA. NR 38 TC 38 Z9 38 U1 0 U2 1 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 SN 0148-0227 J9 J GEOPHYS RES-OCEANS JI J. Geophys. Res.-Oceans PD JUN 15 PY 1992 VL 97 IS C6 BP 9411 EP 9422 DI 10.1029/92JC00688 PG 12 WC Oceanography SC Oceanography GA JA086 UT WOS:A1992JA08600004 ER PT J AU ADVANI, AH THADHANI, NN GREBE, HA HEAPS, R COFFIN, C KOTTKE, T AF ADVANI, AH THADHANI, NN GREBE, HA HEAPS, R COFFIN, C KOTTKE, T TI DYNAMIC MODELING OF MATERIAL AND PROCESS PARAMETER EFFECTS ON SELF-PROPAGATING HIGH-TEMPERATURE SYNTHESIS OF TITANIUM CARBIDE CERAMICS SO JOURNAL OF MATERIALS SCIENCE LA English DT Article ID COMBUSTION SYNTHESIS AB A dynamic, finite-difference model evaluation of titanium carbide (TiC) ceramic processing by self-propagation high-temperature synthesis (SHS) has revealed that material and process parameters have a significant influence on SHS reaction propagation kinetics. Examination of the effects of Ti:C stoichiometry variations and the presence of pre-reacted TiC diluents in the initial (Ti + C) reactant powder mix indicates that off-stoichiometric ratios and dilution additions tend to lower SHS reaction velocities. Increasing compact preheat temperatures, lowering powder particle sizes and raising compact packing densities, on the other hand, cause a significant increase in this reaction variable. Model results are supported by experimental studies on dilution, stoichiometry and preheat temperature effects on SHS velocity, and other literature data on packing density and particle size effects on this parameter. Simulations also suggest that effects of these initial conditions are due to their influence on adiabatic reaction temperatures and heat transfer patterns produced during the process. Critical selection of initial material and process conditions thus appears to be of vital importance during SHS processing of TiC ceramics. C1 UNIV TEXAS,DEPT MET & MAT ENGN,EL PASO,TX 79968. NEW MEXICO INST MIN & TECHNOL,CTR EXPLOS TECHNOL RES,SOCORRO,NM 87801. USA,BALLIST RES LABS,ABERDEEN PROVING GROUND,MD 21005. RP ADVANI, AH (reprint author), UNIV TEXAS,INST MFG & MAT MANAGEMENT,EL PASO,TX 79968, USA. NR 27 TC 23 Z9 23 U1 0 U2 2 PU CHAPMAN HALL LTD PI LONDON PA 2-6 BOUNDARY ROW, LONDON, ENGLAND SE1 8HN SN 0022-2461 J9 J MATER SCI JI J. Mater. Sci. PD JUN 15 PY 1992 VL 27 IS 12 BP 3309 EP 3317 DI 10.1007/BF01116030 PG 9 WC Materials Science, Multidisciplinary SC Materials Science GA HZ752 UT WOS:A1992HZ75200029 ER PT J AU BARUT, AO DOWLING, JP AF BARUT, AO DOWLING, JP TI BAND-STRUCTURE FOR NEUTRAL MAGNETIC DIPOLES IN A PERIODIC MAGNETIC-FIELD - A SIMPLE SPIN POLARIZER SO PHYSICAL REVIEW LETTERS LA English DT Article ID ULTRACOLD NEUTRONS; VELOCITIES AB The solution to the Pauli spinor equation for a neutral magnetic dipole in a periodic magnetic field gives rise to an energy band structure as a consequence of Bloch's theorem. Since the two spin components see differing potentials, it is possible to arrange the magnetic field so that only the kinetic energy corresponding to one spin component is in a band while that of the other is in a band gap. Only one component from an incident beam would propagate through the oscillating field while the other would be completely reflected. Hence, a very efficient polarizing filter is obtained. C1 USA,MISSILE COMMAND,CTR RES DEV & ENGN,WEAPONS SCI DIRECTORATE,AMSMI RD WS ST,REDSTONE ARSENAL,AL 35898. RP BARUT, AO (reprint author), UNIV COLORADO,DEPT PHYS,CAMPUS BOX 390,BOULDER,CO 80309, USA. RI DOWLING, JONATHAN/L-2749-2013 NR 17 TC 13 Z9 13 U1 0 U2 1 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0031-9007 J9 PHYS REV LETT JI Phys. Rev. Lett. PD JUN 15 PY 1992 VL 68 IS 24 BP 3571 EP 3574 DI 10.1103/PhysRevLett.68.3571 PG 4 WC Physics, Multidisciplinary SC Physics GA HY943 UT WOS:A1992HY94300022 ER PT J AU LEMIRE, GW SAUSA, RC AF LEMIRE, GW SAUSA, RC TI DETECTION AND SPECTROSCOPIC STUDIES OF GAS-PHASE OH-KR BY LASER-INDUCED FLUORESCENCE SO JOURNAL OF PHYSICAL CHEMISTRY LA English DT Article ID MULTIPHOTON IONIZATION SPECTROSCOPY; VANDERWAALS MOLECULES; VIBRATIONAL PREDISSOCIATION; AR; NO; COMPLEXES; SPECTRUM; STATE AB The van der Waals complex OH-Kr has been detected in a free jet expansion by laser-induced fluorescence (LIF) near the (1,0) band of the A2-SIGMA+ <-- X2-PI(i) transition of uncomplexed OH. The excitation spectrum reveals a progression of vibrational bands which have been assigned to the stretching motion of the complex. A Birge-Sponer plot of this progression yields a fundamental frequency of omega(e)' = 196 +/- 8 cm-1 and an anharmonicity constant of omega(e)'chi(c)' = 7.4 +/- 0.7 cm-1 for the A2-SIGMA+ excited state. The lower limit of the binding energy of thc complex is measured as D0'(nu'=1) greater-than-or-equal-to 1131 cm-1. These results are compared to those obtained from recent gas-phase LIF studies on the OH-Ne and OH-Ar complexes near the A2-SIGMA+ <-- X2-PI(i) (0,0) and (1,0) bands of OH, respectively, and those from a matrix LIF study on the OH-Kr complex near the (2,0) band of OH, C1 USA, BALLIST RES LAB, SLCBR-IB-I, ABERDEEN PROVING GROUND, MD 21005 USA. NR 26 TC 14 Z9 14 U1 0 U2 3 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0022-3654 J9 J PHYS CHEM-US JI J. Phys. Chem. PD JUN 11 PY 1992 VL 96 IS 12 BP 4821 EP 4824 DI 10.1021/j100191a019 PG 4 WC Chemistry, Physical SC Chemistry GA HY322 UT WOS:A1992HY32200019 ER PT J AU TROUMBLEY, PF LENZ, ER AF TROUMBLEY, PF LENZ, ER TI APPLICATION OF COX INTERACTION-MODEL OF CLIENT HEALTH BEHAVIOR IN A WEIGHT CONTROL PROGRAM FOR MILITARY PERSONNEL - A PREINTERVENTION BASE-LINE SO ADVANCES IN NURSING SCIENCE LA English DT Article ID PHYSICAL-FITNESS; OVERWEIGHT; PROMOTION; EXERCISE; RISK AB This study represents a limited application of Cox's Interaction Model of Client Health Behavior in a weight control program for enlisted US Army soldiers. Relationships of client singularity variables (demographic characteristics, motivation, psychological distress, and designation as overweight or normal weight) to one another and to preintervention measures of client outcomes (health status, health risk) were examined in a sample of 154 soldiers. Hypotheses deduced from the model were tested using multiple regression. The Cox model received partial support, in that some client singularity variables were interrelated: they explained nearly half of the variance in health status, but less than 25% of the variance in health risk. Demographic characteristics were not effective predictors in the present study, perhaps because of the homogeneous sample. The model has potential utility for providing baseline information for preventive health programs in occupational settings. C1 UNIV MARYLAND,SCH NURSING,DOCTORAL PROGRAM,BALTIMORE,MD 21201. RP TROUMBLEY, PF (reprint author), USA,MED RES & DEV COMMAND,FREDERICK,MD 21701, USA. NR 29 TC 6 Z9 6 U1 1 U2 1 PU ASPEN PUBL INC PI FREDERICK PA 7201 MCKINNEY CIRCLE, FREDERICK, MD 21701 SN 0161-9268 J9 ADV NURS SCI JI Adv. Nurs. Sci. PD JUN PY 1992 VL 14 IS 4 BP 65 EP 78 PG 14 WC Nursing SC Nursing GA HT838 UT WOS:A1992HT83800007 PM 1605589 ER PT J AU ROBINSON, JRC LACEWELL, RD STOLL, JR FREEMAN, R AF ROBINSON, JRC LACEWELL, RD STOLL, JR FREEMAN, R TI ESTIMATING AGRICULTURAL BENEFITS FROM DRAINAGE OVER A RELATIVELY LEVEL TERRAIN SO AGRICULTURAL WATER MANAGEMENT LA English DT Article AB Many regions of the world incur flooding and a high water table over a relatively large, level land area. Methodology was developed and programmed for analysis of soil drainage and flood protection benefits in such regions. Estimates of yield loss were elicited from South Texas farmers for floods occurring on average once every year (i.e. 100% flood frequency or probability of occurrence), once every 2 years ( 50% flood frequency), once every 5 years (20% flood frequency), once every 10 years (10% flood frequency), and once every 25 years (4% flood frequency). The Agricultural Benefits Estimator model, ABE, was applied to an analysis of subsurface drainage improvements and flood protection for 0.25 million ha in the South Texas study area. Results indicate substantial project benefits from both lowering the water table and providing alternative levels of reduced flooding. For the case study, the present value of benefits to agriculture from flood protection were estimated at $83.1 million for protection from flooding events with a 50% flood frequency. Estimated benefits were $88.2 million for flood protection through the 20% flood frequency, and benefits increased by another $2.7 million ($90.9 million total) for flood protection through the 10% flood frequency. C1 UNIV WISCONSIN,DEPT URBAN & PUBL AFFAIRS,GREEN BAY,WI 54302. USA,DEPT ARMY,CORPS ENGINEERS,GALVESTON,TX. RP ROBINSON, JRC (reprint author), TEXAS A&M UNIV SYST,DEPT AGR ECON,COLLEGE STN,TX 77843, USA. NR 15 TC 0 Z9 0 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-3774 J9 AGR WATER MANAGE JI Agric. Water Manage. PD JUN PY 1992 VL 21 IS 1-2 BP 79 EP 91 DI 10.1016/0378-3774(92)90084-A PG 13 WC Agronomy; Water Resources SC Agriculture; Water Resources GA JB986 UT WOS:A1992JB98600008 ER PT J AU REDFIELD, RR BIRX, DL AF REDFIELD, RR BIRX, DL TI HIV-SPECIFIC VACCINE THERAPY - CONCEPTS, STATUS, AND FUTURE-DIRECTIONS SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Article ID BLOOD RP REDFIELD, RR (reprint author), WALTER REED ARMY MED CTR,DEPT RETROVIRAL RES,WASHINGTON,DC 20307, USA. NR 21 TC 26 Z9 26 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD JUN PY 1992 VL 8 IS 6 BP 1051 EP 1058 DI 10.1089/aid.1992.8.1051 PG 8 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA JG873 UT WOS:A1992JG87300008 PM 1503819 ER PT J AU BURCH, HB CLEMENT, S SOKOL, MS LANDRY, F AF BURCH, HB CLEMENT, S SOKOL, MS LANDRY, F TI REACTIVE HYPOGLYCEMIC COMA DUE TO INSULIN AUTOIMMUNE SYNDROME - CASE-REPORT AND LITERATURE-REVIEW SO AMERICAN JOURNAL OF MEDICINE LA English DT Article ID LUPUS-ERYTHEMATOSUS; AUTOANTIBODIES; ANTIBODIES; RECEPTOR; PATIENT AB Recurrent episodes of postprandial hypoglycemic symptoms culminated in hypoglycemic coma in a hypertensive but otherwise healthy man while he was taking hydralazine. The patient was found to have an extreme elevation in the immunoreactive insulin level, leading to the discovery of insulin antibodies in the absence of prior exposure to exogenous insulin. Negative results of an anatomic study of the pancreas and an inability to reproduce hypoglycemia during a prolonged fast helped to exclude insulinoma. In contrast, symptomatic hypoglycemia developed in response to oral glucose loading and was associated with an elevation in total and free insulin as well as C-peptide levels. The patient was diagnosed with insulin autoimmune syndrome, which, although a common source of hypoglycemia in Japan, has been well documented in only 15 cases from other countries. HLA typing revealed the patient to be positive for groups Cw4 and DR4, a combination that has been preliminarily associated with insulin autoimmune syndrome in Japan. Unlike the majority of cases previously reported, this patient had no clinical or serologic evidence of an underlying autoimmune disorder and had not been exposed to drugs containing sulfhydryl groups. This case adds to the world literature on insulin autoimmune syndrome, lends support to a postulated HLA association, and documents the presence of insulin autoantibodies in the absence of another underlying autoimmune disorder. C1 WALTER REED ARMY MED CTR,DEPT MED,INTERNAL MED SERV,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT ENDOCRINE METAB,WASHINGTON,DC 20307. NR 19 TC 38 Z9 39 U1 0 U2 0 PU EXCERPTA MEDICA INC PI NEW YORK PA 245 WEST 17TH STREET, NEW YORK, NY 10011 SN 0002-9343 J9 AM J MED JI Am. J. Med. PD JUN PY 1992 VL 92 IS 6 BP 681 EP 685 DI 10.1016/0002-9343(92)90787-C PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA HY439 UT WOS:A1992HY43900015 PM 1605150 ER PT J AU TESAR, JT MCMILLAN, V MOLINA, R ARMSTRONG, J AF TESAR, JT MCMILLAN, V MOLINA, R ARMSTRONG, J TI OPTIC NEUROPATHY AND CENTRAL-NERVOUS-SYSTEM DISEASE ASSOCIATED WITH PRIMARY SJOGRENS-SYNDROME SO AMERICAN JOURNAL OF MEDICINE LA English DT Article ID INFLAMMATORY VASCULAR-DISEASE; LUPUS-ERYTHEMATOSUS; ANTICARDIOLIPIN ANTIBODIES; MANIFESTATIONS; NEURITIS; AUTOANTIBODIES; ANTICOAGULANT; COMPLICATIONS; POPULATION AB Three cases of optic neuropathy associated with primary Sjogren's syndrome are reported. All three patients had clinical manifestations of primary Sjogren's syndrome, although two of the patients did not report sicca symptoms at initial examination. Two patients had focal neurologic signs in addition to optic neuropathy. The differentiation of this syndrome of optic neuropathy, focal neurologic signs, and Sjogren's syndrome from multiple sclerosis and antiphospholipid antibody syndrome is important for reasons of treatment and prognosis. This diagnostic differentiation was facilitated by positive tests for xerophthalmia and findings of positive minor salivary gland biopsy. High titers of antinuclear antibody, anti-SSA(Ro), and anti-SSB(La), and the absence of antiphospholipid antibodies provided additional help in the differential diagnosis. In 5 years of observation, none of the patients developed symptoms of multiple sclerosis or additional connective tissue disorders. C1 MALCOLM GROW AIR FORCE MED CTR,WASHINGTON,DC. RP TESAR, JT (reprint author), WALTER REED ARMY MED CTR,DEPT MED,DIV RHEUMATOL,WASHINGTON,DC 20307, USA. NR 55 TC 43 Z9 46 U1 0 U2 0 PU EXCERPTA MEDICA INC PI NEW YORK PA 245 WEST 17TH STREET, NEW YORK, NY 10011 SN 0002-9343 J9 AM J MED JI Am. J. Med. PD JUN PY 1992 VL 92 IS 6 BP 686 EP 692 DI 10.1016/0002-9343(92)90788-D PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA HY439 UT WOS:A1992HY43900016 PM 1605151 ER PT J AU REID, TJ LOMBARDO, FA REDMOND, J HAMMOND, SL COFFEY, JA OZER, H AF REID, TJ LOMBARDO, FA REDMOND, J HAMMOND, SL COFFEY, JA OZER, H TI DIGITAL VASCULITIS ASSOCIATED WITH INTERFERON THERAPY SO AMERICAN JOURNAL OF MEDICINE LA English DT Note C1 UNIV N CAROLINA,CHAPEL HILL,NC 27514. RP REID, TJ (reprint author), WALTER REED ARMY MED CTR,WASHINGTON,DC 20307, USA. NR 8 TC 41 Z9 41 U1 0 U2 0 PU EXCERPTA MEDICA INC PI NEW YORK PA 245 WEST 17TH STREET, NEW YORK, NY 10011 SN 0002-9343 J9 AM J MED JI Am. J. Med. PD JUN PY 1992 VL 92 IS 6 BP 702 EP 703 DI 10.1016/0002-9343(92)90792-A PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA HY439 UT WOS:A1992HY43900020 PM 1605155 ER PT J AU SMALLRIDGE, RC GIST, ID KIANG, JG AF SMALLRIDGE, RC GIST, ID KIANG, JG TI NA+-H+ ANTIPORT AND MONENSIN EFFECTS ON CYTOSOLIC PH AND IODIDE TRANSPORT IN FRTL-5 RAT-THYROID CELLS SO AMERICAN JOURNAL OF PHYSIOLOGY LA English DT Article DE ALKALINIZATION; IODIDE UPTAKE; ACIDIFICATION ID SODIUM-PROTON-EXCHANGE; INTRACELLULAR PH; THYROGLOBULIN; THYROTROPIN; EFFLUX; ACID; PROLIFERATION; STIMULATION; IONOPHORES; TOXICOLOGY AB Na+-H+ exchange may proceed via an endogenous antiporter or by exposure to the Na+ ionophore monensin. We investigated the characteristics of Na+-H+ exchange induced by antiporter stimulation and by monensin in FRTL-5 rat thyroid cells. We also examined the effects of intracellular pH (pH(i)) changes on iodide uptake and efflux. pH(i) was determined using 2',7'-bis(2-carboxyethyl)-5(6)-carboxyfluorescein. The resting pH(i) was 7.33 +/- 0.02 units; this level correlated directly with extracellular pH. In acid-loaded cells, K(m) for external Na+ activation of the antiporter was 7.1 mM and maximum velocity was 0.3801 DELTA-pH units/min. Dimethylamiloride was 42 times more potent than amiloride in inhibiting sodium-dependent recovery in acidified cells. Metabolic inhibition reduced the initial alkalinization rate. Monensin increased pH(i), and this response was dependent on extracellular Na+ and HCO3- but not on antiporter function. Low-dose monensin (1-mu-M) and 1 mM NH4Cl enhanced I-125 uptake. High-dose monensin (100-mu-M), but not NH4Cl, reduced iodide uptake. Neither NH4Cl nor monensin altered I-125 efflux. Thus FRTL-5 cells possess an amiloride-sensitive Na+-H+ exchanger, which is not essential for maintaining basal pH(i) but is affected by ATP depletion. Monensin also alkalinizes these cells but independently of the antiporter. Iodide uptake, but not efflux, is affected by changes in intracellular Na+ and H+ levels. RP SMALLRIDGE, RC (reprint author), WALTER REED ARMY MED CTR,DEPT CLIN PHYSIOL,DIV MED,WASHINGTON,DC 20307, USA. NR 32 TC 10 Z9 10 U1 0 U2 1 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0002-9513 J9 AM J PHYSIOL JI Am. J. Physiol. PD JUN PY 1992 VL 262 IS 6 BP E834 EP E839 PN 1 PG 6 WC Physiology SC Physiology GA JC376 UT WOS:A1992JC37600035 PM 1319679 ER PT J AU SHANKS, GD EDSTEIN, MD SURIYAMONGKOL, V TIMSAAD, S WEBSTER, HK AF SHANKS, GD EDSTEIN, MD SURIYAMONGKOL, V TIMSAAD, S WEBSTER, HK TI MALARIA CHEMOPROPHYLAXIS USING PROGUANIL/DAPSONE COMBINATIONS ON THE THAI-CAMBODIAN BORDER SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID INVITRO ANTIMALARIAL ACTIVITY; FALCIPARUM MALARIA; DAPSONE; PYRIMETHAMINE; PROPHYLAXIS; CHLOROQUINE; CYCLOGUANIL; RESISTANCE AB The Thai-Cambodian border is a difficult area in which to provide adequate malaria chemoprophylaxis because of multiple drug-resistant Plasmodium falciparum. In 1990-199 1, Thai soldiers were randomly selected to receive proguanil (200 mg/day) combined with dapsone (4 mg or 12.5 mg/day) (n = 184) or pyrimethamine/dapsone (12.5 mg and 100 mg/week) (n = 177). Doxycycline (100 mg/day) was given to men with glucose-6-phosphate dehydrogenase deficiency (n = 77). Falciparum malaria attack rates were the same whether proguanil/dapsone (10.3%) or pyrimethamine/dapsone (11.3%) was used. However, proguanil/dapsone was more effective than pyrimethamine/dapsone in preventing vivax malaria (1.6% versus 12.4%). Men receiving doxycycline had falciparum malaria (3.9%) and vivax malaria (1.3%) at low rates. Adjusting the dapsone component from 4 mg to 12.5 mg did not improve the prophylactic effectiveness. Hematologic toxicity was not observed with the proguanil/dapsone combination. We conclude that proguanil/dapsone is not a useful alternative for malaria chemoprophylaxis on the Thai-Cambodian border. C1 ARMED FORCES RES INST MED SCI,DEPT IMMUNOL & BIOCHEM,BANGKOK,THAILAND. ROYAL THAI NAVY MED DEPT,BANGKOK,THAILAND. RP SHANKS, GD (reprint author), ARMED FORCES RES INST MED SCI,DEPT MED,BANGKOK,THAILAND. RI Shanks, George Dennis/F-4056-2014 OI Shanks, George Dennis/0000-0001-5763-8660 NR 12 TC 37 Z9 37 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JUN PY 1992 VL 46 IS 6 BP 643 EP 648 PG 6 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA JD142 UT WOS:A1992JD14200004 PM 1621888 ER PT J AU HAYES, CG BURANS, JP KSIAZEK, TG DELROSARIO, RA MIRANDA, MEG MANALOTO, CR BARRIENTOS, AB ROBLES, CG DAYRIT, MM PETERS, CJ AF HAYES, CG BURANS, JP KSIAZEK, TG DELROSARIO, RA MIRANDA, MEG MANALOTO, CR BARRIENTOS, AB ROBLES, CG DAYRIT, MM PETERS, CJ TI OUTBREAK OF FATAL ILLNESS AMONG CAPTIVE MACAQUES IN THE PHILIPPINES CAUSED BY AN EBOLA-RELATED FILOVIRUS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID HEMORRHAGIC-FEVER; VIRUS; ZAIRE AB Following the detection of an Ebola-like virus in cynomolgus macaques recently imported into the United States from The Philippines, studies were initiated to document transmission at export facilities located in the latter country. At one export facility, 52.8% of 161 monkeys that died over a 2.5-month period were shown to be infected with this virus using an enzyme-linked immunosorbent assay to detect antigen in liver homogenates. A case fatality rate of 82.4% was documented for the infected monkeys. The initial anti-viral antibody prevalence among the captive macaques at this facility was 25.9% (indirect fluorescent antibody titer greater-than-or-equal-to 1:16). Followup documented infection of 24.4% of initially seronegative animals and 8.7% of initially seropositive monkeys. Being held in a gang cage versus a single cage was found to be a significant risk factor for subsequent virus infection, and the presence of IFA antibody was shown to predict protection. This study documents unequivocally for the first time the presence of an Ebola-related filovirus in Asia. C1 USA,MED RES AINST INFECT DIS,FREDERICK,MD 21701. PHILIPPINE DEPT HLTH,FIELD EPIDEMIOL TRAINING PROGRAM,MANILA,PHILIPPINES. PHILIPPINE DEPT HLTH,TROP MED RES INST,ALABANG,PHILIPPINES. RP HAYES, CG (reprint author), USN,MED RES UNIT 2,MANILA,PHILIPPINES. NR 15 TC 57 Z9 61 U1 1 U2 7 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JUN PY 1992 VL 46 IS 6 BP 664 EP 671 PG 8 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA JD142 UT WOS:A1992JD14200007 PM 1621890 ER PT J AU FRANKE, ED LUCAS, CM SANROMAN, E WIRTZ, RA AF FRANKE, ED LUCAS, CM SANROMAN, E WIRTZ, RA TI PREVALENCE OF ANTIBODY TO THE VARIANT REPEAT OF THE CIRCUMSPOROZOITE PROTEIN OF PLASMODIUM-VIVAX IN PERU SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article AB Individuals living in a malaria-endemic area in northern Peru were found to have antibodies to the variant repeat sequence of the circumsporozoite (CS) protein of Plasmodium vivax. The presence of IgG antibody to the predominant repeat sequence GDRAA/DGQPA represented by the recombinant protein NS1(81) V20 (V20), and the variant repeat sequence ANGAGNQPG contained in the synthetic peptide Pvk247, was determined by enzyme-linked immunosorbent assay. IgG antibodies to the repeats were present in 78 (26%) of 298 serum samples; 56% of the positive serum samples had antibodies to V20 and 60% had antibodies to Pvk247. These findings stress the importance of considering the variant epitope in designing a vaccine based on the repeat region of the vivax CS protein. In a malaria-endemic area such as the one in this study, in which exposure to the variant repeat epitope may be as frequent as exposure to the predominant repeat, a vaccine based solely on the predominant repeat epitope may be ineffective against the variant form. C1 OCCIDENTAL PETR CORP PERU,ANDOAS,PERU. WALTER REED ARMY MED CTR,DEPT ENTOMOL,WASHINGTON,DC 20307. RP FRANKE, ED (reprint author), USN,MED RES INST DETACHMENT,LIMA,PERU. RI Villasante, Eileen/G-3602-2011 NR 6 TC 10 Z9 11 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JUN PY 1992 VL 46 IS 6 BP 708 EP 710 PG 3 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA JD142 UT WOS:A1992JD14200012 PM 1621895 ER PT J AU GRAVES, PM DOUBROVSKY, A SATTABONGKOT, J BATTISTUTTA, D AF GRAVES, PM DOUBROVSKY, A SATTABONGKOT, J BATTISTUTTA, D TI HUMAN-ANTIBODY RESPONSES TO EPITOPES ON THE PLASMODIUM-FALCIPARUM GAMETOCYTE ANTIGEN PFS 48/45 AND THEIR RELATIONSHIP TO INFECTIVITY OF GAMETOCYTE CARRIERS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID TRANSMISSION-BLOCKING IMMUNITY; PAPUA-NEW-GUINEA; MALARIA TRANSMISSION; MONOCLONAL-ANTIBODIES; TARGET ANTIGENS; SEXUAL STAGES AB Antibodies in human sera recognizing epitopes I, IIa, III, and IV on the Plasmodium falciparum gametocyte antigen Pfs 48/45 have been investigated by competitive enzyme-linked immunosorbent assay. More than one-third of the residents of three villages in Madang, Papua New Guinea responded to epitopes I, IIa and III, with little variation by village or with time. There was a bimodal distribution of positive sera by age, with the highest proportion of responders in the 5-9- and > 20-year-old age groups. The data suggest a lower prevalence of antibodies against epitopes IIa and III in P. falciparum gametocyte carriers than in non-carriers. Enhancement of binding of monoclonal antibodies to epitopes IIa and III was also observed more frequently with sera from gametocyte carriers. Sera from gametocyte carriers in Papua New Guinea and Thailand, whose infectivity to mosquitoes had been tested, were used to examine the relationship between recognition of particular epitopes and infectivity. There was a significant association between lack of infectivity of P. falciparum gametocyte carriers and recognition of epitope IIa on Pfs 48/45 by antibodies in their sera. C1 ARMED FORCES RES INST MED SCI,BANGKOK,THAILAND. RP GRAVES, PM (reprint author), ROYAL BRISBANE HOSP,BANCROFT CTR,QUEENSLAND INST MED RES,BRISBANE,QLD 4029,AUSTRALIA. RI Graves, Patricia/J-8691-2014 OI Graves, Patricia/0000-0002-5215-3901 NR 20 TC 28 Z9 28 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JUN PY 1992 VL 46 IS 6 BP 711 EP 719 PG 9 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA JD142 UT WOS:A1992JD14200013 PM 1377881 ER PT J AU KOLB, RA STEKLER, HO AF KOLB, RA STEKLER, HO TI INFORMATION-CONTENT OF LONG-TERM EMPLOYMENT FORECASTS SO APPLIED ECONOMICS LA English DT Article AB The long-term forecasts of employment in different industries are evaluated. A statistical measure which may be used to test the hypothesis that the forecasts provide an accurate picture of the structure of the labour market is used. The statistical measure is based on information theory. The results were mixed with respect to the hypothesis, with the conclusions depending on the extent to which the data were rounded, i.e. the accuracy which was expected. C1 NATL DEF UNIV,IND COLL ARMED FORCES,WASHINGTON,DC 20319. RP KOLB, RA (reprint author), US MIL ACAD,W POINT,NY 10996, USA. NR 7 TC 1 Z9 1 U1 0 U2 1 PU ROUTLEDGE PI LONDON PA 11 NEW FETTER LANE, LONDON, ENGLAND EC4P 4EE SN 0003-6846 J9 APPL ECON JI Appl. Econ. PD JUN PY 1992 VL 24 IS 6 BP 593 EP 596 DI 10.1080/00036849200000027 PG 4 WC Economics SC Business & Economics GA HW534 UT WOS:A1992HW53400006 ER PT J AU COLE, MW HARVEY, JF LUX, RA ECKART, DW TSU, R AF COLE, MW HARVEY, JF LUX, RA ECKART, DW TSU, R TI MICROSTRUCTURE OF VISIBLY LUMINESCENT POROUS SILICON SO APPLIED PHYSICS LETTERS LA English DT Article AB The microstructure of luminescent porous silicon, formed by electrochemical etching of silicon wafers has been characterized by cross-sectional high-resolution transmission electron microscopy. Results of this study reveal the structure to consist of Si crystallites. The crystallites are approximately 3.5 nm in size and are randomly distributed throughout the porous Si region. C1 UNIV N CAROLINA,CHARLOTTE,NC 28223. RP COLE, MW (reprint author), USA,ELECTR TECHNOL & DEVICES LAB,FT MONMOUTH,NJ 07703, USA. NR 10 TC 109 Z9 113 U1 1 U2 3 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD JUN 1 PY 1992 VL 60 IS 22 BP 2800 EP 2802 DI 10.1063/1.106832 PG 3 WC Physics, Applied SC Physics GA HW729 UT WOS:A1992HW72900031 ER PT J AU SAAD, RW DOMLOGEHULTSCH, N YANCEY, KB BENSON, PM JAMES, WD AF SAAD, RW DOMLOGEHULTSCH, N YANCEY, KB BENSON, PM JAMES, WD TI CHILDHOOD LOCALIZED VULVAR PEMPHIGOID IS A TRUE VARIANT OF BULLOUS PEMPHIGOID SO ARCHIVES OF DERMATOLOGY LA English DT Article ID DERMATITIS; ANTIGEN AB Background-Childhood localized vulvar pemphigoid has been recently reported in four girls. A fifth child with this proposed rare variant of bullous pemphigoid is described. Moreover, findings in the various immunopathologic studies we performed establish this entity as a true morphologic variant of bullous pemphigoid. Observations.-In situ deposits of IgG in this patient's epidermal basement membrane zone localized to the epidermal side of 1 mol/L of saline-split skin. Moreover, the patient had circulating IgG autoantibodies that bound the epidermal side of 1 mol/L of saline-split skin in indirect immunofluorescence microscopy and immunoprecipitated the 230-kd bullous pemphigoid antigen from biosynthetically radiolabeled human keratinocyte extracts. These laboratory findings are identical to those documented in patients with the generalized "classic" form of bullous pemphigoid. Conclusions.-This study demonstrates that a child with clinical, histopathologic, and immunopathologic features of localized vulvar pemphigoid had circulating autoantibodies that identify a specific keratinocyte antigen, the bullous pemphigoid antigen, which may serve as a molecular marker for this disease. C1 UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. RP SAAD, RW (reprint author), WALTER REED ARMY MED CTR,DERMATOL SERV,WASHINGTON,DC 20307, USA. FU NIAMS NIH HHS [AR37446] NR 17 TC 22 Z9 22 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0003-987X J9 ARCH DERMATOL JI Arch. Dermatol. PD JUN PY 1992 VL 128 IS 6 BP 807 EP 810 DI 10.1001/archderm.128.6.807 PG 4 WC Dermatology SC Dermatology GA HY066 UT WOS:A1992HY06600010 PM 1599268 ER PT J AU VOGEL, JA AF VOGEL, JA TI OBESITY AND ITS RELATION TO PHYSICAL-FITNESS IN THE UNITED-STATES MILITARY SO ARMED FORCES & SOCIETY LA English DT Article ID WEIGHT; WOMEN; MEN AB As a result of new emphasis placed upon physical fitness and body fatness in June 1981 (DoD directive no. 1308.1), obesity has largely disappeared from the armed forces. Each service has developed an upperlimit for body fat based on one or more of the following criteria: physical performance, military appearance, and health. Physical fitness or the capacity for physical performance is related to body fatness and/or muscularity, depending on the nature of the physical task. Aerobic fitness (e.g., running) is negatively related to body fat content but unrelated to strenght fitness, while strenght fitness (e.g., lifting) is unrelated to fatness but positively related to muscle mass. Implementation and enforcement of standards for both fatness and muscularity will increase physical readiness and conserve manpower of our military forces. RP VOGEL, JA (reprint author), USA,ENVIRONM MED RES INST,NATICK,MA 01760, USA. NR 16 TC 4 Z9 4 U1 0 U2 1 PU TRANSACTION PERIOD CONSORTIUM PI NEW BRUNSWICK PA DEPT 3091 RUTGERS-THE STATE UNIV OF NJ, NEW BRUNSWICK, NJ 08903 SN 0095-327X J9 ARMED FORCES SOC JI Armed Forces Soc. PD SUM PY 1992 VL 18 IS 4 BP 497 EP 513 DI 10.1177/0095327X9201800404 PG 17 WC Political Science; Sociology SC Government & Law; Sociology GA JM373 UT WOS:A1992JM37300004 ER PT J AU MCCANN, UD PENETAR, DM SHAHAM, Y THORNE, DR GILLIN, JC SING, HC THOMAS, MA BELENKY, G AF MCCANN, UD PENETAR, DM SHAHAM, Y THORNE, DR GILLIN, JC SING, HC THOMAS, MA BELENKY, G TI SLEEP-DEPRIVATION AND IMPAIRED COGNITION - POSSIBLE ROLE OF BRAIN CATECHOLAMINES SO BIOLOGICAL PSYCHIATRY LA English DT Article ID SUBCORTICAL DEMENTIA; CORTEX; HUMANS AB To assess the role of brain catecholamines in cognitive decline associated with sleep deprivation, 40 healthy male volunteers were randomized to conditions of total sleep deprivation or 40.5 h of rest. Within each sleep condition, subjects were further randomized to treatment with a 2-day regimen of placebo or alpha-methyl-para-tyrosine (AMPT), a catecholamine synthesis inhibitor. Cognitive performance was measured repeatedly over time using a computerized performance assessment battery. Treatment with AMPT or treatment with sleep deprivation increased sleepiness without producing marked or consistent deterioration in performance. By contrast, subjects who received both treatments reported greater sleepiness than those receiving either treatment alone, and developed severe cognitive impairment on a variety of tasks. These findings, along with previous evidence that catecholamine-enhancing drugs improve performance in sleep-deprived individuals, support the view that decline in cognitive performance during sleep deprivation may be mediated by brain catecholamines. C1 WALTER REED ARMY MED CTR,DEPT BEHAV BIOL,WASHINGTON,DC 20307. UNIV CALIF SAN DIEGO,DEPT PSYCHIAT,LA JOLLA,CA 92093. LA JOLLA VET ADM HOSP,LA JOLLA,CA. RI Sanguansri, Luz/B-6630-2011; shaham, yavin/G-1306-2014 OI Sanguansri, Luz/0000-0003-1908-7604; NR 49 TC 44 Z9 46 U1 2 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0006-3223 J9 BIOL PSYCHIAT JI Biol. Psychiatry PD JUN 1 PY 1992 VL 31 IS 11 BP 1082 EP 1097 DI 10.1016/0006-3223(92)90153-Q PG 16 WC Neurosciences; Psychiatry SC Neurosciences & Neurology; Psychiatry GA JK718 UT WOS:A1992JK71800002 PM 1356024 ER PT J AU CASTEEL, DA JUNG, KE GERENA, L MILHOUS, W AF CASTEEL, DA JUNG, KE GERENA, L MILHOUS, W TI SYNTHESIS AND ANTIMALARIAL EVALUATION OF 2,3,5-TRIOXABICYCLO[2.2.2]OCTANES, MODELS FOR THE PUTATIVE PHARMACOPHORE OF QINGHAOSU (ARTEMISININ) SO BIOORGANIC & MEDICINAL CHEMISTRY LETTERS LA English DT Article ID 1,2,4-TRIOXANES; INVITRO; AGENTS AB 5-Hydroperoxy-2-methoxytetrahydropyrans are cyclized with transacetalization in the presence of Amberlyst-15 and molecular sieves to 2,3,5-trioxabicyclo[2.2.2]octanes. models of the proposed pharmacophore of qirighaosu. These bridged bicyclic trioxanes exhibit only marginal antimalarial activity. RP CASTEEL, DA (reprint author), WALTER REED ARMY MED CTR,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307, USA. NR 18 TC 5 Z9 5 U1 0 U2 3 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0960-894X J9 BIOORG MED CHEM LETT JI Bioorg. Med. Chem. Lett. PD JUN PY 1992 VL 2 IS 6 BP 623 EP 626 DI 10.1016/S0960-894X(01)81211-7 PG 4 WC Chemistry, Medicinal; Chemistry, Organic SC Pharmacology & Pharmacy; Chemistry GA JA816 UT WOS:A1992JA81600024 ER PT J AU ADAMSENDER, CL AF ADAMSENDER, CL TI AMERICA CHANGING WORKFORCE SO CHEMTECH LA English DT Editorial Material RP ADAMSENDER, CL (reprint author), USA,MIL DIST WASHINGTON,FT BELVOIR,VA 22060, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0009-2703 J9 CHEMTECH JI Chemtech PD JUN PY 1992 VL 22 IS 6 BP 327 EP 328 PG 2 WC Chemistry, Applied SC Chemistry GA HY856 UT WOS:A1992HY85600002 ER PT J AU PEACOCK, MD JOHNSON, JE AF PEACOCK, MD JOHNSON, JE TI UTILIZATION OF ACUTE BRONCHODILATOR RESPONSES IN STABLE COPD TO PREDICT THE RELATIVE EFFICACY OF INDIVIDUAL AGENTS SO CHEST LA English DT Article ID OBSTRUCTIVE PULMONARY-DISEASE; AIR-FLOW LIMITATION; CHRONIC-BRONCHITIS; THERAPY; THEOPHYLLINE; VARIABILITY; DYSPNEA AB A survey of four inhaled beta-agonist agents was evaluated as a means of selecting the optimum agent for chronic therapy in patients with stable COPD. Eighteen patients completed as protocol of prebronchodilator and postbronchodilator spirometry utilizing albuterol, metaproterenol, pirbuterol, and terbutaline daily in random order. Subsequently, each patient received treatment with either the greatest or least response-invoking agent for four weeks, followed by a second interval with the opposite agent. At the end of each interval, the results of repeat spirometry, arterial blood gas determinations, 12-min walks, dyspnea questionnaires, and self-monitored peak expiratory flow rates were recorded. Use of the greatest response-invoking agent resulted in significantly larger prebronchodilator and postbronchodilator FEV1 and FVC. No other study factor was significantly different. Acute bronchodilator surveys may have a role in medication selection in view of the improvement in spirometric volumes. C1 BROOKE ARMY MED CTR,DEPT MED,PULM DIS CRIT CARE SERV,FT SAM HOUSTON,TX 78234. NR 24 TC 1 Z9 1 U1 0 U2 0 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 USA SN 0012-3692 J9 CHEST JI Chest PD JUN PY 1992 VL 101 IS 6 BP 1552 EP 1557 DI 10.1378/chest.101.6.1552 PG 6 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA HX708 UT WOS:A1992HX70800017 PM 1600772 ER PT J AU TOPOL, EJ CALIFF, RM VANDORMAEL, M GRINES, CL GEORGE, BS SANZ, ML WALL, T OBRIEN, M SCHWAIGER, M AGUIRRE, FV YOUNG, S POPMA, JJ SIGMON, KN LEE, KL ELLIS, SG ELLIS, S NABEL, E BATES, E WALTON, J GORMAN, L KLINE, E MAINO, J BAUMANN, G DOYLE, C MANGELSEN, M LAMB, P SHAH, S SHERMAN, N WAHR, D HOLLAND, K JUDGE, R VANDENBELT, R GENOVESE, B DICARLO, L STEELE, R WILSON, S BRANDT, R FISHER, J SMITH, F ROSENBLUM, S ZUEHLKE, D MCCLAIN, M BURR, A WALL, T BENGTSON, J HONAN, M OCONNOR, C QUIGLEY, P MANTELL, S BERRIOS, E SNEED, L FLANNAGAN, C LUI, M KLINKER, K STRICKLAND, J MASOUD, J GRINER, G DIMEO, M WILCOCKSON, W CHIDER, S PATHMAN, D MELE, P HOEKSTRA, J DEVINE, GM BEASLEY, CR HEDGE, SB KNIGHT, EB LEE, HN NAIK, SN RICHARDSON, DL HELMS, DV CANDELA, R CHAPEKIS, A FRZIER, R MAYO, J MASEK, R PICKEL, A KEREIAKES, DJ ABBOTTSMITH, CW MARTIN, L ANDERSON, L HIGBY, N ROTH, E SMITH, M DRAKE, D BOATRIGHT, D SAMAHA, JK FLANAGAN, W WILSON, B MCGREW, F GRIFFIN, B WORLEY, SJ BAULT, JH GENTZLER, RD SMITH, ID SLOVAK, JP SUPPLE, FW LEED, D LANE, S RAMSEY, D VANDORMAEL, M AGUIRRE, F CHAITMAN, B DELIGONUL, U KENNEDY, H KERN, M LABOVITZ, A MILLER, L SAMUELS, L WEINS, R THORNTON, T MAJOR, M HAMILTON, W DEANE, L STICKLEY, L FERRARA, R LINDEMAN, J DWYER, J GIBSON, P DUCK, SC GRINES, CL GURLEY, J NISSEN, S BOOTHE, D BRANCO, M GASH, D HARLAMERT, E DEMARIA, A BENNETT, K CUTSHAW, B BENZONI, T RUOCCO, NA BRUSH, J FAXON, D GARBER, G JACOBS, A PODRID, P ROTHENDLER, J RYAN, T HANKIN, B SANZ, ML GABSTER, AA GOREN, CC JOHNSON, LW KNAPP, JF REED, GH STONE, JR WILSON, WS MAYER, D PUPA, L BAILEY, S MOODY, M CONDOS, W GILMAN, J ANDERSON, JL KARAGOUNIS, L MORENO, F MARSHALL, H IPSEN, S WOODLIEF, L KARNASH, S ARONSON, L BOSWICK, J SIGMON, K MILLER, J ALLEN, T WILSON, G COHEN, H WALKER, B LUCAS, K CORTRIGHT, C LEE, K CALIFF, R DEBOWEY, D KUNKLE, J BONDI, D POPMA, J SCHWAIGER, M SQUICCIARINI, S STAFFORD, K HONAN, M SHEIK, K KIM, S LONGABAUGH, P WAGNER, G CLEMMENSEN, P STUMP, D THORNTON, D MACY, E AF TOPOL, EJ CALIFF, RM VANDORMAEL, M GRINES, CL GEORGE, BS SANZ, ML WALL, T OBRIEN, M SCHWAIGER, M AGUIRRE, FV YOUNG, S POPMA, JJ SIGMON, KN LEE, KL ELLIS, SG ELLIS, S NABEL, E BATES, E WALTON, J GORMAN, L KLINE, E MAINO, J BAUMANN, G DOYLE, C MANGELSEN, M LAMB, P SHAH, S SHERMAN, N WAHR, D HOLLAND, K JUDGE, R VANDENBELT, R GENOVESE, B DICARLO, L STEELE, R WILSON, S BRANDT, R FISHER, J SMITH, F ROSENBLUM, S ZUEHLKE, D MCCLAIN, M BURR, A WALL, T BENGTSON, J HONAN, M OCONNOR, C QUIGLEY, P MANTELL, S BERRIOS, E SNEED, L FLANNAGAN, C LUI, M KLINKER, K STRICKLAND, J MASOUD, J GRINER, G DIMEO, M WILCOCKSON, W CHIDER, S PATHMAN, D MELE, P HOEKSTRA, J DEVINE, GM BEASLEY, CR HEDGE, SB KNIGHT, EB LEE, HN NAIK, SN RICHARDSON, DL HELMS, DV CANDELA, R CHAPEKIS, A FRZIER, R MAYO, J MASEK, R PICKEL, A KEREIAKES, DJ ABBOTTSMITH, CW MARTIN, L ANDERSON, L HIGBY, N ROTH, E SMITH, M DRAKE, D BOATRIGHT, D SAMAHA, JK FLANAGAN, W WILSON, B MCGREW, F GRIFFIN, B WORLEY, SJ BAULT, JH GENTZLER, RD SMITH, ID SLOVAK, JP SUPPLE, FW LEED, D LANE, S RAMSEY, D VANDORMAEL, M AGUIRRE, F CHAITMAN, B DELIGONUL, U KENNEDY, H KERN, M LABOVITZ, A MILLER, L SAMUELS, L WEINS, R THORNTON, T MAJOR, M HAMILTON, W DEANE, L STICKLEY, L FERRARA, R LINDEMAN, J DWYER, J GIBSON, P DUCK, SC GRINES, CL GURLEY, J NISSEN, S BOOTHE, D BRANCO, M GASH, D HARLAMERT, E DEMARIA, A BENNETT, K CUTSHAW, B BENZONI, T RUOCCO, NA BRUSH, J FAXON, D GARBER, G JACOBS, A PODRID, P ROTHENDLER, J RYAN, T HANKIN, B SANZ, ML GABSTER, AA GOREN, CC JOHNSON, LW KNAPP, JF REED, GH STONE, JR WILSON, WS MAYER, D PUPA, L BAILEY, S MOODY, M CONDOS, W GILMAN, J ANDERSON, JL KARAGOUNIS, L MORENO, F MARSHALL, H IPSEN, S WOODLIEF, L KARNASH, S ARONSON, L BOSWICK, J SIGMON, K MILLER, J ALLEN, T WILSON, G COHEN, H WALKER, B LUCAS, K CORTRIGHT, C LEE, K CALIFF, R DEBOWEY, D KUNKLE, J BONDI, D POPMA, J SCHWAIGER, M SQUICCIARINI, S STAFFORD, K HONAN, M SHEIK, K KIM, S LONGABAUGH, P WAGNER, G CLEMMENSEN, P STUMP, D THORNTON, D MACY, E TI A RANDOMIZED TRIAL OF LATE REPERFUSION THERAPY FOR ACUTE MYOCARDIAL-INFARCTION SO CIRCULATION LA English DT Article DE MYOCARDIAL REPERFUSION; THROMBOLYSIS; MYOCARDIAL INFARCTION; CORONARY ARTERY THROMBOSIS; ANGIOPLASTY ID TISSUE PLASMINOGEN-ACTIVATOR; 12-MONTH FOLLOW-UP; CORONARY THROMBOLYSIS; INTRACORONARY STREPTOKINASE; VENTRICULAR-FUNCTION; LATE POTENTIALS; TIMI TRIAL; PHASE-I; REDUCTION; MORTALITY AB Background. Experimental and observational clinical studies of acute coronary occlusion have suggested that late reperfusion prevents infarct expansion and facilitates myocardial healing. The purpose of this trial was to assess whether infarct vessel patency could be achieved in late-entry patients and what benefit, if any, can be demonstrated. Methods and Results. In a double-blind fashion, 197 patients with 6 to 24 hours of symptoms and ECG ST elevation were randomly assigned to tissue-type plasminogen activator (100 mg over 2 hours) or placebo. Coronary angiography within 24 hours was used to determine infarct vessel patency status. Patients with infarct-related occluded arteries were then eligible for a second randomization to either angioplasty (34 patients) or no angioplasty (37 patients). Ventricular function and cavity size were reassessed at 1 month by gated blood pool scintigraphy and at 6 months by repeat cardiac catheterization. The primary end point, infarct vessel patency, was 65% for plasminogen activator patients compared with 27% in the placebo group (p<0.0001). There were no differences between these groups in ejection fraction or infarct zone regional wall motion at 1 or 6 months. At 6 months, infarct vessel patency was 59% in both groups. In the placebo group, there was a significant increase in end-diastolic volume from acute phase of 127 ml to 159 ml at 6-month follow-up (p=0.006) but no increase in cavity size or the plasminogen activator group patients. Coronary angioplasty was associated with an initial 81% recanalization success and improved ventricular function at 1 month, but by late follow-up no advantage could be demonstrated for this procedure, and there was a 38% spontaneous recanalization rate in the patients assigned to no angioplasty. Conclusions. The study demonstrates that it is possible to achieve infarct vessel recanalization in the majority of late-entry patients with either thrombolytic therapy or angioplasty. Thrombolytic intervention had a favorable effect on prevention of cavity dilatation and left ventricular remodeling, but there are no late benefits on systolic function after thrombolysis or coronary angioplasty. The conclusions concerning overall potential benefit of applying late reperfusion therapy will require data from large-scale trials designed to assess mortality reduction. C1 UNIV MICHIGAN,DIV CARDIOL,ANN ARBOR,MI 48109. DUKE UNIV,DEPT MED,DIV CARDIOL,DURHAM,NC 27706. ST LOUIS UNIV HOSP,ST LOUIS,MO 63104. RIVERSIDE METHODIST HOSP,COLUMBUS,OH 43214. UNIV KENTUCKY HOSP,LEXINGTON,KY. ST PATRICKS HOSP,MISSOULA,MT. LATTER DAY ST HOSP,SALT LAKE CITY,UT 84143. BROOKE ARMY HOSP,SAN ANTONIO,TX. BOSTON UNIV HOSP,BOSTON,MA 02218. CHRIST HOSP,CINCINNATI,OH 45219. LANCASTER GEN HOSP,LANCASTER,PA. BAPTIST MEM HOSP,MEMPHIS,TN 38146. WA FOOTE MEM HOSP,CTR COLLABORATING,JACKSON,MI. ST JOSEPH MERCY HOSP,ANN ARBOR,MI 48104. ALAMANCE CTY & ALAMANCE MEM HOSP,BURLINGTON,NJ. SE GEN HOSP,LUMBERTON,NC. CHRIST HOSP,CINCINNATI,OH 45219. OUR LADY MERCY HOSP ADERSON,CINCINNATI,OH. ST LOUIS UNIV,MED CTR,ST LOUIS,MO 63103. ST JOHNS MERCY MED CTR,ST LOUIS,MO 63141. ST JOSEPH HOSP,KIRKWOOD,MO. UNIV KENTUCKY,MED CTR,LEXINGTON,KY 40506. BOSTON UNIV,MED CTR,BOSTON,MA 02215. MIDDLE KENTUCKY RIVER MED CTR,JACKSON,KY. BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234. DUKE UNIV,MED CTR,MED CTR,TAMI COORDINATING CTR,DURHAM,NC 27710. UNIV MICHIGAN,MED CTR,ANGIOG CORE LAB,ANN ARBOR,MI 48109. DUKE UNIV,MED CTR,MED CTR,NUCL SCINTIG CORE LAB,DURHAM,NC 27710. DUKE UNIV,ECHOCARDIOG CORE LAB,DURHAM,NC 27706. UNIV VERMONT,HEMATOL CORE LAB,BURLINGTON,VT 05405. RP TOPOL, EJ (reprint author), CLEVELAND CLIN FDN,DEPT CARDIOL,1 CLIN CTR,9500 EUCLID AVE,CLEVELAND,OH 44195, USA. OI schwaiger, markus /0000-0002-2305-7144 NR 47 TC 183 Z9 190 U1 0 U2 4 PU AMER HEART ASSOC PI DALLAS PA 7272 GREENVILLE AVENUE, DALLAS, TX 75231-4596 SN 0009-7322 J9 CIRCULATION JI Circulation PD JUN PY 1992 VL 85 IS 6 BP 2090 EP 2099 PG 10 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease SC Cardiovascular System & Cardiology GA HX707 UT WOS:A1992HX70700014 PM 1591828 ER PT J AU BAHWAWSI, E AF BAHWAWSI, E TI ENGINEERS CAN PERFORM TEST AUTOMATICALLY SO CIVIL ENGINEERING LA English DT Letter RP BAHWAWSI, E (reprint author), CORPS ENGINEERS,MISSOURI RIVER DIV,OMAHA,NE, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASCE-AMER SOC CIVIL ENGINEERS PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0885-7024 J9 CIVIL ENG JI Civil Eng. PD JUN PY 1992 VL 62 IS 6 BP 42 EP 42 PG 1 WC Engineering, Civil SC Engineering GA HW271 UT WOS:A1992HW27100012 ER PT J AU NELSON, ME AF NELSON, ME TI APPROPRIATE TECHNOLOGY FOR FLOOD WARNINGS SO CIVIL ENGINEERING LA English DT Article AB Computers can help protect cities and other developed areas by enhancing flood warning systems, but smaller communities may not be able to take advantage of their sophistication. The Corps of Engineers has solved this problem by developing more workable systems for semirural areas. A flood in Nebraska has proved that the system works. RP NELSON, ME (reprint author), USA,CORPS ENGINEERS,OMAHA DIST,HYDROL & METEOROL SECT,OMAHA,NE, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASCE-AMER SOC CIVIL ENGINEERS PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0885-7024 J9 CIVIL ENG JI Civil Eng. PD JUN PY 1992 VL 62 IS 6 BP 64 EP 66 PG 3 WC Engineering, Civil SC Engineering GA HW271 UT WOS:A1992HW27100019 ER PT J AU SCOLLARD, DM BHOOPAT, L KESTENS, L VANHAM, G DOUGLAS, JT MOAD, J AF SCOLLARD, DM BHOOPAT, L KESTENS, L VANHAM, G DOUGLAS, JT MOAD, J TI IMMUNE-COMPLEXES AND ANTIBODY-LEVELS IN BLISTERS OVER HUMAN LEPROSY SKIN-LESIONS WITH OR WITHOUT ERYTHEMA-NODOSUM LEPROSUM SO CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY LA English DT Article ID MONOCLONAL RHEUMATOID-FACTOR; SUCTION-INDUCED BLISTERS; LEPROMATOUS PATIENTS; CHEMOTHERAPY; COMPONENTS; COMPLEMENT; C1Q C1 CHIANG MAI UNIV,HLTH SCI RES INST,CHIANG MAI,THAILAND. PRINCE LEOPOLD INST TROP MED,ANTWERP,BELGIUM. TRIPLER ARMY MED CTR,HONOLULU,HI 96816. RP SCOLLARD, DM (reprint author), UNIV HAWAII,DEPT PATHOL,HONOLULU,HI 96816, USA. NR 29 TC 15 Z9 15 U1 0 U2 0 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0090-1229 J9 CLIN IMMUNOL IMMUNOP JI Clin. Immunol. Immunopathol. PD JUN PY 1992 VL 63 IS 3 BP 230 EP 236 DI 10.1016/0090-1229(92)90227-F PG 7 WC Immunology; Pathology SC Immunology; Pathology GA HV927 UT WOS:A1992HV92700004 PM 1623643 ER PT J AU DEVER, LL MARTIN, JW SEAWORTH, B JORGENSEN, JH AF DEVER, LL MARTIN, JW SEAWORTH, B JORGENSEN, JH TI VARIED PRESENTATIONS AND RESPONSES TO TREATMENT OF INFECTIONS CAUSED BY MYCOBACTERIUM-HAEMOPHILUM IN PATIENTS WITH AIDS SO CLINICAL INFECTIOUS DISEASES LA English DT Article ID HEMOPHILUM AB We describe three patients with AIDS who developed clinically significant infection with Mycobacterium haemophilum. One patient had skin and bone involvement and suspected laryngeal involvement; the second had extensive abdominal adenopathy with partial bowel obstruction; and the third presented with limited skin involvement. Each patient responded transiently to antimycobacterial therapy, but disease recurred and progressed in all three cases. Recovery of M. haemophilum requires a high level of clinical suspicion and special handling of mycobacterial cultures by the microbiology laboratory, including cultivation on enriched chocolate agar or heme-supplemented media and incubation at 30-degrees-C for up to 8 weeks. Characteristic patterns of drug susceptibility for this organism have been only partially defined. Reported responses to antimycobacterial therapy in AIDS patients with M. haemophilum infection have been poor, and the optimal therapeutic regimen is not yet known. The prognosis for recovery appears to depend heavily on host-related factors, particularly the degree of immunosuppression. C1 UNIV TEXAS,HLTH SCI CTR,DEPT PATHOL,7703 FLOYD CURL DR,SAN ANTONIO,TX 78284. UNIV TEXAS,HLTH SCI CTR,DEPT MED,DIV INFECT DIS,SAN ANTONIO,TX 78284. BROOKE ARMY MED CTR,DEPT MED,INFECT DIS SERV,FT SAM HOUSTON,TX 78234. SAN ANTONIO STATE CHEST HOSP,SAN ANTONIO,TX. FU NIAID NIH HHS [T32-AI-07271-07] NR 24 TC 59 Z9 59 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD JUN PY 1992 VL 14 IS 6 BP 1195 EP 1200 PG 6 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA HW264 UT WOS:A1992HW26400004 PM 1623075 ER PT J AU RICHTERMENGE, JA AF RICHTERMENGE, JA TI US RESEARCH IN ICE MECHANICS - 1987-1990 SO COLD REGIONS SCIENCE AND TECHNOLOGY LA English DT Review ID BRITTLE COMPRESSIVE FRACTURE; FRESH-WATER ICE; POLYCRYSTALLINE ICE; SEA-ICE; ELASTIC-ANISOTROPY; CRACK NUCLEATION; STRAIN-RATE; STRESS; MODEL; TOUGHNESS AB This compilation of US ice mechanics investigations over 1987-1990 focuses on efforts that support the development of our understanding of sea ice interaction. Both ice-structure and ice-ice interaction studies have been included in hopes that insights from one area will complement developments in the other. The work discussed in the area of ice-structure interaction was intentionally limited to lateral movement of the ice against a vertical structure. It is these results that can be most easily extended to ice-ice interaction events. RP RICHTERMENGE, JA (reprint author), USA,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 150 TC 1 Z9 1 U1 1 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-232X J9 COLD REG SCI TECHNOL JI Cold Reg. Sci. Tech. PD JUN PY 1992 VL 20 IS 3 BP 231 EP 246 DI 10.1016/0165-232X(92)90031-O PG 16 WC Engineering, Environmental; Engineering, Civil; Geosciences, Multidisciplinary SC Engineering; Geology GA JD512 UT WOS:A1992JD51200001 ER PT J AU HAYNES, FD ZARLING, JP GOOCH, GE AF HAYNES, FD ZARLING, JP GOOCH, GE TI PERFORMANCE OF A THERMOSIPHON WITH A 37-METER-LONG, HORIZONTAL EVAPORATOR SO COLD REGIONS SCIENCE AND TECHNOLOGY LA English DT Article AB Laboratory tests were conducted on a thermosyphon with a 37-m-long, horizontal evaporator. This evaporator section was placed in a water tank so that the rate of ice growth on it could be determined. Unit conductance values were calculated for wind speeds of 0 to 5.4 m/s applied to the condenser section. Using these conductance values ina finite element analysis indicated that thermosyphons with horizontal evaporators and condensate return devices were adequate for use in many foundation designs in permafrost regions. C1 UNIV ALASKA,DEPT MECH ENGN,FAIRBANKS,AK 99701. RP HAYNES, FD (reprint author), USA,COLD REG RES & ENGN LAB,HANOVER,NH 03755, USA. NR 12 TC 3 Z9 5 U1 0 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-232X J9 COLD REG SCI TECHNOL JI Cold Reg. Sci. Tech. PD JUN PY 1992 VL 20 IS 3 BP 261 EP 269 DI 10.1016/0165-232X(92)90033-Q PG 9 WC Engineering, Environmental; Engineering, Civil; Geosciences, Multidisciplinary SC Engineering; Geology GA JD512 UT WOS:A1992JD51200003 ER PT J AU SELLMANN, PV DELANEY, AJ CHAMBERLAIN, EJ DUNTON, KH AF SELLMANN, PV DELANEY, AJ CHAMBERLAIN, EJ DUNTON, KH TI SEA-FLOOR TEMPERATURE AND CONDUCTIVITY DATA FROM STEFANSSON SOUND, ALASKA SO COLD REGIONS SCIENCE AND TECHNOLOGY LA English DT Article ID SHALLOW AB Overconsolidated sediments, seasonal seafloor freezing,and ice-bonded permafrost are unique features in shallow arctic coastal waters. They are related to low seawater temperatures and varying salinities. Seabed temperatures can be less than - 1.0-degrees-C for much of the year, with noticeable warming occurring only during the summer months. Observations from recent deployment of three instruments in Stefansson Sound and data from an earlier deployment, which included sites in Harrison Bay, showed decreasing mean annual seafloor temperatures with increasing water depth, ranging from - 0.9-degrees-C in 4.4 m of water to - 1.6-degrees-C in 14 m of water. Salinities also varied seasonally, with noticeable freshening developing during the summer and highly uniform values occurring during the winter. Periodic temperature and salinity measurements at sites in Stefansson Sound, made during August 1987 and August 1989, also helped verify the data obtained with the seabottom instruments. Seasonal freezing of the seabed can begin in late September and may noticeably change its engineering properties. In areas of coarse-grained sediments, ice bonding and strengthening of the seabed can result. In areas of fine-grained sediments it appears that seasonal freezing of the seafloor can cause overconsolidation of the seabed sediments. This densification process can result in a significant permanent increase in strength. RP SELLMANN, PV (reprint author), USA,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 11 TC 3 Z9 3 U1 1 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-232X J9 COLD REG SCI TECHNOL JI Cold Reg. Sci. Tech. PD JUN PY 1992 VL 20 IS 3 BP 271 EP 288 DI 10.1016/0165-232X(92)90034-R PG 18 WC Engineering, Environmental; Engineering, Civil; Geosciences, Multidisciplinary SC Engineering; Geology GA JD512 UT WOS:A1992JD51200004 ER PT J AU SJOGREN, JA AF SJOGREN, JA TI CLOSED-FORM SOLUTION OF DECOMPOSABLE STOCHASTIC-MODELS SO COMPUTERS & MATHEMATICS WITH APPLICATIONS LA English DT Article AB Markov and semi-Markov processes are increasingly being used in the modeling of complex reconfigurable systems (fault-tolerant computers). The estimation of the reliability (or some measure of performance) of the system reduces to solving the process for its state probabilities. Such a model may exhibit numerous states and complicated transition distributions, contributing to an expensive and numerically delicate solution procedure. Thus, when a system exhibits a decomposition property, either structurally (autonomous subsystems), or behaviorally (component failure versus reconfiguration), it is desirable to exploit this decomposition in the reliability calculation. In interesting cases there can be failure states which arise from non-failure states of the subsystems. We present equations which allow the computation of failure probabilities of the total (combined) model without requiring a complete solution of the combined model. This material is presented within the context of closed-form functional representation of probabilities as utilized in the Symbolic Hierarchical Automated Reliability and Performance Evaluator (SHARPE) tool. The techniques adopted enable one to compute such probability function for a much wider class of systems at a reduced computational cost. Several examples show how the method is used, especially in enhancing the versatility of the SHARPE tool. RP SJOGREN, JA (reprint author), USA,LANGLEY RES CTR,ARMY AVION RES & DEV ACTIV,HAMPTON,VA 23665, USA. NR 26 TC 0 Z9 0 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0898-1221 J9 COMPUT MATH APPL JI Comput. Math. Appl. PD JUN PY 1992 VL 23 IS 12 BP 43 EP 67 DI 10.1016/0898-1221(92)90091-U PG 25 WC Computer Science, Interdisciplinary Applications; Mathematics, Applied SC Computer Science; Mathematics GA HR288 UT WOS:A1992HR28800004 ER PT J AU MURPHY, JR MCNALLY, P PELLER, P SHAY, SS AF MURPHY, JR MCNALLY, P PELLER, P SHAY, SS TI PROLONGED CLEARANCE IS THE PRIMARY ABNORMAL REFLUX PARAMETER IN PATIENTS WITH PROGRESSIVE SYSTEMIC-SCLEROSIS AND ESOPHAGITIS SO DIGESTIVE DISEASES AND SCIENCES LA English DT Article DE ESOPHAGUS; PROGRESSIVE SYSTEMIC SCLEROSIS; SCINTIGRAPHY; PH MONITORING; MANOMETRY; ESOPHAGEAL REFLUX ID RHYTHMIC SPONTANEOUS CONTRACTIONS; SPHINCTER PRESSURE MEASUREMENT; GASTROESOPHAGEAL REFLUX; GASTROINTESTINAL MANIFESTATIONS; MANOMETRIC PHENOMENON; REPETITIVE EPISODES; SCLERODERMA; MECHANISMS; SYMPTOMS; DETERIORATION AB The purpose of this study is to determine if frequent reflux events from an incompetent LES or poor clearance from decreased peristalsis is the predominant abnormality in PSS patients with severe reflux esophagitis. Seven patients with both classic manometric findings of PSS and endoscopic findings of esophageal ulcerations and/or Barrett's esophagus were compared to nine patients with similar endoscopic findings but with no evidence of a connective tissue disorder. All patients underwent simultaneous intraesophageal pH monitoring and scintigraphy for a total of 40 min after a radiolabeled meal. Four of the PSS patients and all the non-PSS patients had simultaneous manometry. We found that PSS patients had significantly fewer reflux events (P < 0.01), but the reflux events had significantly longer duration (P < 0.01) compared to patients with similar severity of esophagitis and no connective tissue disease. We conclude that decreased smooth muscle peristalsis appears to be the primary contributor to acid exposure and esophageal injury in PSS. C1 WALTER REED ARMY MED CTR,DEPT NUCL MED,WASHINGTON,DC 20307. RP MURPHY, JR (reprint author), WALTER REED ARMY MED CTR,DEPT MED,GASTROENTEROL SERV,WASHINGTON,DC 20307, USA. NR 24 TC 44 Z9 44 U1 0 U2 0 PU PLENUM PUBL CORP PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 SN 0163-2116 J9 DIGEST DIS SCI JI Dig. Dis. Sci. PD JUN PY 1992 VL 37 IS 6 BP 833 EP 841 DI 10.1007/BF01300380 PG 9 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA HW289 UT WOS:A1992HW28900005 PM 1587187 ER PT J AU POZO, L OCONNOR, MA AF POZO, L OCONNOR, MA TI UNITED-STATES-ARMY CONQUERS PAPER MONSTER WITH IMAGING TECHNOLOGY SO DOCUMENT & IMAGE AUTOMATION LA English DT Article AB The U.S. Army Publications and Printing Command (USAPPC), the organization responsible for printing and publishing the 65,000-odd forms, circulars, manuals, and pamphlets required by the U.S. Army, faces many of the problems shared by paper-intensive organizations: astronomical printing and storage costs, extensive waste, frequent misfiling, and enormous labor requirements. This article describes how the USAPPC used CD-ROM technology to convert thousands of its most commonly used forms, circulars, pamphlets, and other documents to digital format, thus making access to and distribution of these documents cheaper, faster, and more efficient. C1 USA,PUBLICAT & PRINTING COMMAND,CD ROM,ASZQ PG,ALEXANDRIA,VA 22331. MULTIMEDIA CD PUBLISHER,COLORADO SPRINGS,CO 80949. NR 0 TC 0 Z9 0 U1 0 U2 1 PU PHILIPS BUSINESS INFOR PI POTOMAC PA 1201 SEVEN LOCKS RD, POTOMAC, MD 20854 SN 1071-6130 J9 DOC IMAGE AUTOM PD SUM PY 1992 VL 12 IS 2 BP 36 EP 38 PG 3 WC Computer Science, Information Systems; Imaging Science & Photographic Technology SC Computer Science; Imaging Science & Photographic Technology GA JD843 UT WOS:A1992JD84300007 ER PT J AU LUCIER, C BOUCHER, M WHITE, J CANGEMI, J KOWALSKI, C AF LUCIER, C BOUCHER, M WHITE, J CANGEMI, J KOWALSKI, C TI EXPLORING VALUES OF JAPANESE AND AMERICAN MANAGEMENT-SYSTEMS SO EDUCATION LA English DT Article AB Since the emergence of "quality circles," Japanese management systems have been scrutinized by Americans in order to translate their methods and results into healthier U.S. organizations and profits. This article reviews the components of Japanese organizations which developed from societal values and culture. Because of the differences in American and Japanese values, reproduction of organizational components to American systems is impossible. However, an analysis of two theories of Japanese managerial behavior, Ouichi's Theory Z and Pascale and Athos' Seven S's, is presented which identifies specific components of the Japanese system that could benefit American organizations. This article also discusses the emphasis Japanese place on group orientation and identity, deferment of profits for long-term gain, and commitment to quality at every organizational level. The authors conclude that in order to compete within an ever-changing world economy, American enterprises must re-evaluate current management systems and incorporate successful components of other systems. C1 WESTERN KENTUCKY UNIV,DEPT PSYCHOL,BOWLING GREEN,KY 42101. OHIO STATE UNIV,COLL BUSINESS,COLUMBUS,OH 43210. RP LUCIER, C (reprint author), USA,DIV ARMORED,FT KNOX,KY 40121, USA. NR 31 TC 0 Z9 0 U1 0 U2 1 PU PROJECT INNOVATION PI CHULA VISTA PA 1362 SANTA CRUZ CT, CHULA VISTA, CA 92010 SN 0013-1172 J9 EDUCATION PD SUM PY 1992 VL 112 IS 4 BP 487 EP 498 PG 12 WC Education & Educational Research SC Education & Educational Research GA JH001 UT WOS:A1992JH00100002 ER PT J AU GAZONAS, GA FORD, JC AF GAZONAS, GA FORD, JC TI UNIAXIAL COMPRESSION TESTING OF M30 AND JA2 GUN PROPELLANTS USING A STATISTICAL DESIGN STRATEGY SO EXPERIMENTAL MECHANICS LA English DT Article AB A statistical factorial design strategy is used to determine the uniaxial compressive mechanical response of two energetic polymers, M30 and JA2 gun propellants, as a function of strain rate, e, temperature, T, specimen aspect ratio, l/d, and specimen-end lubrication, L. A model of the mechanical response, y = y(e, T, l/d, L) is formed using least-squares minimization of observed behavior with a second-order polynomial model in the independent variables. It is found that aspect ratio and end-lubrication variables can influence the overall mechanical behavior of these materials, so that their effects must be quantitatively evaluated and screened prior to the development of constitutive models. Model predictions and global root-mean-square, RMS, errors in yield stress and strain, strain-energy density at yield, compressive and 'failure' moduli for these materials compare favorably with historical values obtained from a replicate test design strategy. RP GAZONAS, GA (reprint author), USA,BALLIST RES LABS,ABERDEEN PROVING GROUND,MD 21005, USA. OI Gazonas, George/0000-0002-2715-016X NR 26 TC 3 Z9 4 U1 1 U2 2 PU SOC EXPERIMENTAL MECHANICS PI BETHEL PA 7 SCHOOL STREET, BETHEL, CT 06801 SN 0014-4851 J9 EXP MECH JI Exp. Mech. PD JUN PY 1992 VL 32 IS 2 BP 154 EP 162 DI 10.1007/BF02324727 PG 9 WC Materials Science, Multidisciplinary; Mechanics; Materials Science, Characterization & Testing SC Materials Science; Mechanics GA JF521 UT WOS:A1992JF52100010 ER PT J AU SINA, BJ WRIGHT, C BALLOU, R HOLLINGDALE, M AF SINA, BJ WRIGHT, C BALLOU, R HOLLINGDALE, M TI A PROTECTIVE MONOCLONAL-ANTIBODY WITH DUAL SPECIFICITY FOR PLASMODIUM-FALCIPARUM AND PLASMODIUM-BERGHEI CIRCUMSPOROZOITE PROTEINS SO EXPERIMENTAL PARASITOLOGY LA English DT Article DE PLASMODIUM-FALCIPARUM; PLASMODIUM-BERGHEI; MALARIA; CIRCUMSPOROZOITE PROTEIN; MONOCLONAL ANTIBODIES; SPOROZOITE IMMUNITY ID CONTINUOUS CULTURES; SYNTHETIC PEPTIDES; INFECTED MOSQUITOS; MALARIA PARASITE; SURFACE-ANTIGEN; SPOROZOITE; VACCINE; INVITRO; CELLS; IMMUNOGENICITY C1 UNIVAX CORP,ROCKVILLE,MD 20852. WALTER REED ARMY MED CTR,DEPT IMMUNOL,WASHINGTON,DC 20307. RP SINA, BJ (reprint author), BIOMED RES INST,12111 PARKLAWN DR,ROCKVILLE,MD 20852, USA. NR 42 TC 5 Z9 5 U1 0 U2 1 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0014-4894 J9 EXP PARASITOL JI Exp. Parasitol. PD JUN PY 1992 VL 74 IS 4 BP 431 EP 440 DI 10.1016/0014-4894(92)90205-O PG 10 WC Parasitology SC Parasitology GA HY296 UT WOS:A1992HY29600007 PM 1375561 ER PT J AU SINGH, VP MORTON, DC AF SINGH, VP MORTON, DC TI A MODEL FOR ELECTROLUMINESCENCE IN SRS - CE ACTFEL DISPLAY DEVICES SO IEEE TRANSACTIONS ON ELECTRON DEVICES LA English DT Article ID LUMINESCENCE; FILMS; EU AB An analytical model for electroluminescence in SrS:Ce ac thin-film electroluminescent display devices is presented. The model incorporates an exact calculation of electric field and the effect of activator ionization and bulk traps. Activator ionization is needed to explain several features of luminescence behavior in SrS:Ce devices. These features include the second luminescence peak at the trailing edge of the voltage pulse and the time lag between the luminescence and the applied voltage when the applied voltage consists of bipolar trapezoidal pulses and rectangular pulses of low voltage amplitudes. As a mechanism for the ionization of activators, field-assisted tunneling is shown to be more likely than the impact ionization by hot electrons. Physical processes are described in terms of rate equations and field, current and luminescence waveforms are calculated for one set of device parameters. The shape of the calculated luminescence waveforms is similar to the shape of the experimentally observed waveforms. More importantly, variations in shape of luminescence-time waveforms with voltage amplitude mirror the experimentally observed variations. C1 USA,LABCOM,ELECTR TECHNOL & DEVICES LAB,DISPLAYS GRP,FT MONMOUTH,NJ 07703. RP SINGH, VP (reprint author), UNIV TEXAS,DEPT ELECT ENGN,EL PASO,TX 79968, USA. NR 34 TC 22 Z9 22 U1 0 U2 2 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9383 J9 IEEE T ELECTRON DEV JI IEEE Trans. Electron Devices PD JUN PY 1992 VL 39 IS 6 BP 1331 EP 1340 DI 10.1109/16.137303 PG 10 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA HU978 UT WOS:A1992HU97800010 ER PT J AU CURRY, R CHAMPNEY, D EICHENBERGER, C FOCKLER, J MORTON, D SEARS, R SMITH, I CONRAD, R AF CURRY, R CHAMPNEY, D EICHENBERGER, C FOCKLER, J MORTON, D SEARS, R SMITH, I CONRAD, R TI THE DEVELOPMENT AND TESTING OF SUBNANOSECOND-RISE, KILOHERTZ OIL SWITCHES FOR THE GENERATION OF HIGH-FREQUENCY IMPULSES SO IEEE TRANSACTIONS ON PLASMA SCIENCE LA English DT Article AB An experimental program was undertaken at Pulse Sciences, Inc. to demonstrate a switch technology capable of generating picosecond-risetime, multimegawatt pulses. Various technologies reviewed included laser-triggered GaAs switches, ferrite sharpening lines. and spark gap technologies [1]-[3]. The goal of the program was to both identify and demonstrate a technology which could be scaled to hundreds of kilovolts as well as operate at kilohertz repetition rates. A picosecond-risetime, long-lifetime switch (less-than-or-equal-to 10(6)-10(7) shots) was also required. Review of three technologies showed one near-term candidate for the research program. GaAs switches were found to be both highly developmental and to have short lifetimes at hundreds of kilovolts [4]. Similarly, ferrite sharpening lines appeared to have a voltage limitation. Thus spark gap technology capable of being scaled to much higher repetition rates and energy switching regimes was explored. One such switch, a flowing oil gap switch, was investigated. These subnanosecond-risetime, kilohertz oil switches have been developed and tested at Pulse Sciences, Inc. The development was divided into two phases. During the first phase, a two to three pulse breakdown test at 130 kV was used to measure the recovery characteristics of a large-area oil switch at up to 200 pps. Different geometries were explored along with oil flow rates required. The oil flow experiments and the effect of electrode/flow geometry are reported. Successful test results in the first phase led to the phase II design of a high-repetition-rate modulator based on flowed oil switches that develop pulses tens of nanoseconds in duration. The modulator incorporates three oil switches: (1) a transfer switch, (2) an output switch, and (3) a sharpening switch. Initial operation and parameterization have shown operation and recovery of the oil switches at up to 290 kV and repetition rates of 200 pps respectively. Lower-voltage tests at 140 kV and 170 kV have shown recovery at up to 1250 and 1000 pps. Peak energies of 50 J per pulse have been transferred into a 97-OMEGA resistive load, with a 280 ps risetime[5]. The modulator design and performance are reported. The influence of electrode/flow geometry upon the recovery of oil switches is described, along with the breakdown and other characteristics of the switches. C1 USA,MISSILE COMMAND,REDSTONE ARSENAL,AL 35809. RP CURRY, R (reprint author), PULSE SCI INC,600 MCCORMICK ST,SAN LEANDRO,CA 94577, USA. NR 8 TC 12 Z9 14 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0093-3813 J9 IEEE T PLASMA SCI JI IEEE Trans. Plasma Sci. PD JUN PY 1992 VL 20 IS 3 BP 383 EP 392 DI 10.1109/27.142840 PG 10 WC Physics, Fluids & Plasmas SC Physics GA JA870 UT WOS:A1992JA87000032 ER PT J AU CASSELS, FJ DEAL, CD REID, RH JARBOE, DL NAUSS, JL CARTER, JM BOEDEKER, EC AF CASSELS, FJ DEAL, CD REID, RH JARBOE, DL NAUSS, JL CARTER, JM BOEDEKER, EC TI ANALYSIS OF ESCHERICHIA-COLI COLONIZATION FACTOR ANTIGEN-I LINEAR B-CELL EPITOPES, AS DETERMINED BY PRIMATE RESPONSES, FOLLOWING PROTEIN-SEQUENCE VERIFICATION SO INFECTION AND IMMUNITY LA English DT Article ID POLYVINYLIDENE DIFLUORIDE MEMBRANES; MULTIPLE PEPTIDE-SYNTHESIS; NUCLEOTIDE-SEQUENCE; MONOCLONAL-ANTIBODIES; SYSTEMATIC SYNTHESIS; FIMBRIAL ANTIGEN; BINDING; DIARRHEA; PURIFICATION; CHEMISTRY AB Colonization factor antigen I (CFA/I)-bearing strains of enterotoxigenic Escherichia coli (ETEC) are responsible for a significant percentage of ETEC diarrheal disease worldwide whether the disease presents as infant diarrhea with high mortality or as traveler's diarrhea. CFA/I pili (fimbriae) are virulence determinants that consist of repeating protein subunits (pilin), are found in several ETEC serogroups, and promote attachment to human intestinal mucosa. While CFA/I pili are highly immunogenic, the antigenic determinants of CFA/I have not been defined. We wished to identify the linear B-cell epitopes within the CFA/I molecule as determined by primate response to the immunizing protein. To do this, we (i) resolved the discrepancies in the literature on the complete amino acid sequence of CFA/I by N-terminal and internal protein sequencing of purified and selected proteolytic fragments of CFA/I, (ii) utilized this sequence to synthesize 140 overlapping octapeptides covalently attached to polyethylene pins which represented the entire CFA/I protein, (iii) immunized three rhesus monkeys with multiple intramuscular injections of purified CFA/I subunit in Freund's adjuvant, and (iv) tested serum from each monkey for its ability to recognize the octapeptides in a capture enzyme-linked immunosorbent assay. Eight linear B-cell epitopes were identified; the region containing an epitope at amino acids 11 to 21 was strongly recognized by all three individual rhesus monkeys, while the amino acid stretches 22 to 29, 66 to 74, 93 to 101, and 124 to 136 each contained an epitope that was recognized by two of the three rhesus monkeys. The three other regions containing epitopes were recognized by one of the three individuals. The monkey antiserum to pilus subunits recognized native intact pili by immunogold labeling of CFA/I pili present on whole H10407 cells. Therefore, immunization with pilus subunits induces antibody that clearly recognizes both synthetic linear epitopes and intact pili. We are currently studying the importance of these defined epitope-containing regions as vaccine candidates. C1 WALTER REED ARMY MED CTR,DEPT BACTERIAL DIS,WASHINGTON,DC 20307. RP CASSELS, FJ (reprint author), WALTER REED ARMY MED CTR,DEPT GASTROENTEROL,WASHINGTON,DC 20307, USA. RI Carter, John Mark/K-2485-2015 OI Carter, John Mark/0000-0001-8251-4168 NR 45 TC 20 Z9 20 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD JUN PY 1992 VL 60 IS 6 BP 2174 EP 2181 PG 8 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA HX421 UT WOS:A1992HX42100005 PM 1375193 ER PT J AU KOTLOFF, KL HERRINGTON, DA HALE, TL NEWLAND, JW VANDEVERG, L COGAN, JP SNOY, PJ SADOFF, JC FORMAL, SB LEVINE, MM AF KOTLOFF, KL HERRINGTON, DA HALE, TL NEWLAND, JW VANDEVERG, L COGAN, JP SNOY, PJ SADOFF, JC FORMAL, SB LEVINE, MM TI SAFETY, IMMUNOGENICITY, AND EFFICACY IN MONKEYS AND HUMANS OF INVASIVE ESCHERICHIA-COLI K-12 HYBRID VACCINE CANDIDATES EXPRESSING SHIGELLA-FLEXNERI 2A SOMATIC ANTIGEN SO INFECTION AND IMMUNITY LA English DT Article ID ORAL VACCINE; SECRETING CELLS; SONNEI VACCINE; PROTECTION; PROTEIN; IMMUNIZATION; INFECTION; DIARRHEA; IMMUNITY; STRAINS AB A live, oral Shigella vaccine, constructed by transfer of the 140-MDa invasiveness plasmid from Shigella flexneri 5 and the chromosomal genes encoding the group- and type-specific O antigen of S. flexneri 2a to Escherichia coli K-12, was tested in humans. Designated EcSf2a-1, this vaccine produced adverse reactions (fever, diarrhea, or dysentery) in 4 (31%) of 13 subjects who ingested a single dose of 1.0 x 10(9) CFU, while at better-tolerated doses (5.0 x 10(6) to 5.0 x 10(7) CFU), it provided no significant protection against challenge with S. flexneri 2a. A further-attenuated aroD mutant derivative, EcSf2a-2, was then tested. Rhesus monkeys that received EcSf2a-2 in three oral doses of ca. 1.5 x 10(11) CFU experienced no increase in gastrointestinal symptoms compared with a control group that received an E. coli K-12 placebo. Compared with controls, the vaccinated monkeys were protected against shigellosis after challenge with S. flexneri 2a (60% efficacy; P = 0.001). In humans, EcSf2a-2 was well tolerated at inocula ranging from 5.0 x 10(6) to 2.1 x 10(9) CFU. However, after a single dose of 2.5 x 10(9) CFU, 4 (17%) of 23 subjects experienced adverse reactions, including fever (3 subjects) and diarrhea (209 ml) (1 subject), and after a single dose of 1.8 x 10(10) CFU, 2 of 4 subjects developed dysentery. Recipients of three doses of 1.2 to 2.5 x 10(9) CFU had significant rises in serum antibody to lipopolysaccharide (61%) and invasiveness plasmid antigens (44%) and in gut-derived immunoglobulin A antibody-secreting cells specific for lipopolysaccharide (100%) and invasiveness plasmid antigens (60%). Despite its immunogenicity, the vaccine conferred only 36% protection against illness (fever, diarrhea, or dysentery) induced by experimental challenge (P = 0.17). These findings illustrate the use of an epithelial cell-invasive E. coli strain as a carrier for Shigella antigens. Future studies must explore dosing regimens that might optimize the protective effects of the vaccine while eliminating adverse clinical reactions. C1 UNIV MARYLAND,SCH MED,CTR VACCINE DEV,DEPT MED,DIV GEOG MED,BALTIMORE,MD 21201. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DIV COMMUNICABLE DIS & IMMUNOL,WASHINGTON,DC 20307. US FDA,OFF BIOL,DIV PROD QUAL CONTROL,BETHESDA,MD 20205. RP KOTLOFF, KL (reprint author), UNIV MARYLAND,SCH MED,DEPT PEDIAT,DIV INFECT DIS & TROP PEDIAT,BALTIMORE,MD 21201, USA. RI kotloff, karen/E-7768-2012 OI kotloff, karen/0000-0003-1808-6431 NR 34 TC 65 Z9 66 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD JUN PY 1992 VL 60 IS 6 BP 2218 EP 2224 PG 7 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA HX421 UT WOS:A1992HX42100011 PM 1587589 ER PT J AU ELSINGHORST, EA KOPECKO, DJ AF ELSINGHORST, EA KOPECKO, DJ TI MOLECULAR-CLONING OF EPITHELIAL-CELL INVASION DETERMINANTS FROM ENTEROTOXIGENIC ESCHERICHIA-COLI SO INFECTION AND IMMUNITY LA English DT Article ID UNDIFFERENTIATED HUMAN DIARRHEA; TISSUE-CULTURE CELLS; YERSINIA-ENTEROCOLITICA; SHIGELLA-FLEXNERI; MAMMALIAN-CELLS; DNA FRAGMENTS; PLASMID; PROTEIN; IDENTIFICATION; COLONIZATION AB Although penetration of the epithelial mucosa has not been identified as a virulence mechanism in enterotoxigenic Escherichia coli (ETEC), we have found that this pathogen is capable of invading human intestinal cell lines. Classical ETEC strain H10407 was most invasive for epithelial cell lines derived from ileocecal and colonic tissues. An ETEC cosmid library was screened for clones that could direct E. coli HB101 to invade cultured human ileocecal epithelial cells (HCT 8 cells). Three invasive recombinant cosmid clones were isolated. These cosmids could direct HB101 invasion at an efficiency that was equal to or greater than that of the parent ETEC strain. The invasion cosmids also allowed for enhanced HCT 8 cell adherence by HB101. Electron micrographs of ETEC and recombinant HB101 strains revealed intracellular bacteria contained within endocytic vacuoles. Restriction endonuclease mapping and hybridization analyses showed that the three ETEC clones represent two separate invasion systems present in the parent ETEC strain and that both systems are chromosomally encoded. The parent ETEC strain and one cloned invasion system did not invade HeLa cells. Interestingly, one cloned invasion system was capable of directing HB101 to invade HeLa cells. Invasion of HCT 8 cells by recombinant HB101 strains and the parent ETEC strain was inhibited by cytochalasin D, indicating that the wild-type and both cloned invasion systems trigger an actin polymerization-dependent uptake process. It is not known whether the invasive phenotype of ETEC is relevant for enterotoxigenic disease. However, the parent ETEC strain, as well as recombinant HB101 strains, was capable of transcytosis through polarized HCT 8 monolayers. This transcytosis suggests that ETEC may cross the gut epithelium in vivo and that this invasion may have a previously unrecognized role in the disease process. RP ELSINGHORST, EA (reprint author), WALTER REED ARMY MED CTR,DEPT BACTERIAL IMMUNOL,WASHINGTON,DC 20307, USA. NR 41 TC 65 Z9 67 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD JUN PY 1992 VL 60 IS 6 BP 2409 EP 2417 PG 9 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA HX421 UT WOS:A1992HX42100039 PM 1587608 ER PT J AU VERMA, JN RAO, M AMSELEM, S KRZYCH, U ALVING, CR GREEN, SJ WASSEF, NM AF VERMA, JN RAO, M AMSELEM, S KRZYCH, U ALVING, CR GREEN, SJ WASSEF, NM TI ADJUVANT EFFECTS OF LIPOSOMES CONTAINING LIPID-A - ENHANCEMENT OF LIPOSOMAL ANTIGEN PRESENTATION AND RECRUITMENT OF MACROPHAGES SO INFECTION AND IMMUNITY LA English DT Article ID MALARIA SPOROZOITE ANTIGEN; PLASMODIUM-FALCIPARUM; ALUMINUM HYDROXIDE; LIPOPOLYSACCHARIDE; IMMUNOGENICITY; ENDOTOXIN; VACCINE; EPITOPE; LPS AB Liposomes containing lipid A induced potent humoral immune responses in mice against an encapsulated malaria antigen (R32NS1) containing NANP epitopes. The immune response was not enhanced by lipid A alone or by empty liposomes containing lipid A. Experiments to investigate the adjuvant mechanisms of liposomes and lipid A revealed that liposome-encapsulated R32NS1 was actively presented by bone marrow-derived macrophages to NANP-specific cloned T cells. The degree of presentation was related to the amount of liposomal antigen added per macrophage in the culture medium. At high cell densities, poor presentation occurred when liposomes lacked lipid A but excellent presentation occurred when the liposomes contained lipid A. Liposomes containing lipid A and encapsulated antigen also activated gamma interferon-treated macrophages to produce nitric oxide. Macrophage activation and antigen presentation occurred with liposomes that could not be detected by the Limulus amebocyte lysis assay. Intraperitoneal injection of liposomal lipid A caused a marked increase in the recruitment of immature (peroxidase-positive) macrophages to the peritoneum. On the basis of these experiments, we propose that the mechanism of the adjuvant action of liposomal lipid A is partly due to increased antigen presentation by macrophages and partly due to recruitment of an increased number of macrophages serving as antigen-presenting cells. C1 WALTER REED ARMY MED CTR,DEPT MEMBRANE BIOCHEM,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT IMMUNOL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT CELLULAR IMMUNOL,WASHINGTON,DC 20307. NR 31 TC 62 Z9 62 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD JUN PY 1992 VL 60 IS 6 BP 2438 EP 2444 PG 7 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA HX421 UT WOS:A1992HX42100043 PM 1587611 ER PT J AU MANGELSDORFF, AD AF MANGELSDORFF, AD TI REACTIONS OF ARMY MEDICAL RESERVE UNITS TO THE PERSIAN-GULF-WAR SO INTERNATIONAL JOURNAL OF PSYCHOLOGY LA English DT Meeting Abstract C1 USA,HLTH SERV COMMAND,FT SAM HOUSTON,TX 78234. NR 0 TC 0 Z9 0 U1 0 U2 0 PU PSYCHOLOGY PRESS PI HOVE PA 27 CHURCH RD, HOVE, EAST SUSSEX, ENGLAND BN3 2FA SN 0020-7594 J9 INT J PSYCHOL JI Int. J. Psychol. PD JUN-AUG PY 1992 VL 27 IS 3-4 BP 611 EP 611 PG 1 WC Psychology, Multidisciplinary SC Psychology GA JF420 UT WOS:A1992JF42003250 ER PT J AU ANDERSON, JR WEIDEMANN, S HEINEN, D AF ANDERSON, JR WEIDEMANN, S HEINEN, D TI POSTOCCUPANCY EVALUATION AND THE ORGANIZATIONAL CLIENT SO INTERNATIONAL JOURNAL OF PSYCHOLOGY LA English DT Meeting Abstract C1 UNIV ILLINOIS,CHAMPAIGN,IL 61820. USA,CONSTRUCT ENGN RES LAB,WASHINGTON,DC 20310. NR 0 TC 0 Z9 0 U1 0 U2 0 PU PSYCHOLOGY PRESS PI HOVE PA 27 CHURCH RD, HOVE, EAST SUSSEX, ENGLAND BN3 2FA SN 0020-7594 J9 INT J PSYCHOL JI Int. J. Psychol. PD JUN-AUG PY 1992 VL 27 IS 3-4 BP 613 EP 613 PG 1 WC Psychology, Multidisciplinary SC Psychology GA JF420 UT WOS:A1992JF42003261 ER PT J AU HOUSTON, JR AF HOUSTON, JR TI ON THE BEACH SO ISSUES IN SCIENCE AND TECHNOLOGY LA English DT Letter RP HOUSTON, JR (reprint author), USA,CORPS ENGINEERS,CTR COASTAL ENGN RES,VICKSBURG,MS 39180, USA. NR 4 TC 0 Z9 0 U1 0 U2 0 PU NATL ACAD PRESS PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 SN 0748-5492 J9 ISSUES SCI TECHNOL JI Issues Sci. Technol. PD SUM PY 1992 VL 8 IS 4 BP 15 EP 16 PG 2 WC Engineering, Multidisciplinary; Engineering, Industrial; Multidisciplinary Sciences; Social Issues SC Engineering; Science & Technology - Other Topics; Social Issues GA JE506 UT WOS:A1992JE50600014 ER PT J AU FULCO, CS HOYT, RW BAKERFULCO, CJ GONZALEZ, J CYMERMAN, A AF FULCO, CS HOYT, RW BAKERFULCO, CJ GONZALEZ, J CYMERMAN, A TI USE OF BIOELECTRICAL IMPEDANCE TO ASSESS BODY-COMPOSITION CHANGES AT HIGH-ALTITUDE SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE ANTHROPOMETRY; BIOELECTRICAL IMPEDANCE ANALYSES; FAT-FREE MASS; WEIGHT LOSS ID FAT-FREE MASS; VALIDATION; WATER; VOLUMES; PLASMA AB This study determined the feasibility of using bioelectrical impedance analysis (BIA) to assess body composition alterations associated with body weight (BW) loss at high altitude. The BIA method was also evaluated relative to anthropometric assessments. Height, BW, BIA, skinfold (SF, 6 sites), and circumference (CIR, 5 sites) measurements were obtained from 16 males (23-35 yr) before, during, and after 16 days of residence at 3,700-4,300 m. Hydrostatic weighings (HW) were performed pre- and postaltitude. Results of 13 previously derived prediction equations using various combinations of height, BW, age, BIA, SF, or CIR measurements as independent variables to predict fat-free mass (FFM), fat mass (FM), and percent body fat (%Fat) were compared with HW. Mean BW decreased from 84.74 to 78.84 kg (P < 0.01). As determined by HW, FFM decreased by 2.44 kg (P < 0.01), FM by 3.46 kg (P < 0.01), and %Fat by 3.02% (P < 0.01). The BIA and SF methods overestimated the loss in FFM and underestimated the losses in FM and %Fat (P < 0.01). Only the equations utilizing the CIR measurements did not differ from HW values for changes in FFM, FM, and %Fat. It was concluded that the BIA and SF methods were not acceptable for assessing body composition changes at altitude. RP FULCO, CS (reprint author), USA,ENVIRONM MED RES INST,DIV ALTITUDE PHYSIOL & MED,KANSAS ST,NATICK,MA 01760, USA. NR 30 TC 19 Z9 21 U1 0 U2 0 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 8750-7587 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD JUN PY 1992 VL 72 IS 6 BP 2181 EP 2187 PG 7 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA HZ317 UT WOS:A1992HZ31700020 PM 1629071 ER PT J AU BROOKS, GA WOLFEL, EE GROVES, BM BENDER, PR BUTTERFIELD, GE CYMERMAN, A MAZZEO, RS SUTTON, JR WOLFE, RR REEVES, JT AF BROOKS, GA WOLFEL, EE GROVES, BM BENDER, PR BUTTERFIELD, GE CYMERMAN, A MAZZEO, RS SUTTON, JR WOLFE, RR REEVES, JT TI MUSCLE ACCOUNTS FOR GLUCOSE DISPOSAL BUT NOT BLOOD LACTATE APPEARANCE DURING EXERCISE AFTER ACCLIMATIZATION TO 4,300-M SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE EXERTION; SKELETAL MUSCLE; NET LACTATE RELEASE; NET GLUCOSE UPTAKE; LACTATE FLUX; LACTATE SHUTTLE; GLUCOSE FLUX; GLUCOSE DISAPPEARANCE ID SKELETAL-MUSCLE; SARCOLEMMAL VESICLES; PROLONGED EXERCISE; STEADY-STATE; HUMANS; METABOLISM; TURNOVER; RELEASE; RAT; ENERGETICS AB We hypothesized that the increased blood glucose disappearance (Rd) observed during exercise and after acclimatization to high altitude (4,300 m) could be attributed to net glucose uptake (G) by the legs and that the increased arterial lactate concentration and rate of appearance (Ra) on arrival at altitude and subsequent decrease with acclimatization were caused by changes in net muscle lactate release (L). To evaluate these hypotheses, seven healthy males [23 +/- 2 (SE) yr, 72.2 +/- 1.6 kg], on a controlled diet were studied in the postabsorptive condition at sea level, on acute exposure to 4,300 m, and after 3 wk of acclimatization to 4,300 m. Subjects received a primed-continuous infusion of [6,6-D2]glucose (Brooks et al., J. Appl. Physiol. 70:919-927, 1991) and [3-C-13]lactate (Brooks et al., J. Appl. Physiol. 71: 333-341, 1991) and rested for a minimum of 90 min, followed immediately by 45 min of exercise at 101 +/- 3 W, which elicited 51.1 +/- 1% of the sea level peak O2 uptake (65 +/- 2% of both acute altitude and acclimatization peak O2 uptake). Glucose and lactate arteriovenous differences across the legs and arms and leg blood flow were measured. Leg G increased during exercise compared with rest, at altitude compared with sea level, and after acclimatization. Leg G accounted for 27-36% of Rd at rest and essentially all glucose Rd during exercise. A shunting of the blood glucose flux to active muscle during exercise at altitude is indicated. With acute altitude exposure, at 5 min of exercise L was elevated compared with sea level or after acclimatization, but from 15 to 45 min of exercise the pattern and magnitude of L from the legs varied and followed neither the pattern nor the magnitude of responses in arterial lactate concentration or Ra. Leg L accounted for 6-65% of lactate Ra at rest and 17-63% during exercise, but the percent Ra from L was not affected by altitude. Tracer-measured lactate extraction by legs accounted for 10-25% of lactate Rd at rest and 31-83% during exercise. Arms released lactate under all conditions except during exercise with acute exposure to high altitude, when the arms consumed lactate. Both active and inactive muscle beds demonstrated simultaneous lactate extraction and release. We conclude that active skeletal muscle is the predominant site of glucose disposal during exercise and at high altitude but not the sole source of blood lactate during exercise at sea level or high altitude. C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. UNIV COLORADO,DENVER,CO 80262. OI Brooks, George A./0000-0002-1389-1629 FU NHLBI NIH HHS [HL-14985]; NIDDK NIH HHS [DK-19577] NR 41 TC 95 Z9 96 U1 1 U2 2 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 8750-7587 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD JUN PY 1992 VL 72 IS 6 BP 2435 EP 2445 PG 11 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA HZ317 UT WOS:A1992HZ31700054 PM 1629100 ER PT J AU ROBINSON, CP FRANZ, DR BONDURA, ME AF ROBINSON, CP FRANZ, DR BONDURA, ME TI EFFECTS OF PALYTOXIN ON PORCINE CORONARY-ARTERY RINGS SO JOURNAL OF APPLIED TOXICOLOGY LA English DT Article DE PALYTOXIN IN CORONARY ARTERIES; CORONARY ARTERIES; PALYTOXIN; PORCINE ARTERIES ID VASCULAR SMOOTH-MUSCLE; INDUCED CONTRACTION; AORTA; DESENSITIZATION; MECHANISM; FROG AB Palytoxin, in concentrations as low as 100 fM, caused contractions of porcine coronary artery rings. Palytoxin concentrations of < 1 nM caused slowly developing contractions which were not maximal even after 2 h. Rings contracted by 100 nM palytoxin achieved maximal tension by 10 min and relaxed to 53% of that maximum after 2 h. Verapamil (1-mu-M) reduced the rate of contractions induced by 10 nM palytoxin. Exposure of rings to > 10 nM palytoxin for 1-2 h reduced contractions to potassium 18 h later to 61% of the expected contraction and abolished those to palytoxin administered later. Both 10 and 100 nM palytoxin depleted potassium from coronary artery rings. Verapamil (10-mu-M) prevented potassium depletion by 10 nM palytoxin, but neither 10-mu-M verapamil nor 1-mu-M nifedipine prevented potassium depletion in rings exposed to 100 nM palytoxin. Thus, the contractile action and the potassium depleting action of palytoxin on the porcine coronary artery involve mobilization of nifedipine- and verapamil-sensitive calcium. Verapamil- and nifedipine-sensitive calcium was not required for depletion of potassium by the highest PTX concentration (100 nM), however. C1 USA,MED RES INST INFECT DIS,DEPT PATHOPHYSIOL,FREDERICK,MD 21701. RP ROBINSON, CP (reprint author), UNIV OKLAHOMA,HLTH SCI CTR,COLL PHARM,OKLAHOMA CITY,OK 73190, USA. NR 23 TC 1 Z9 1 U1 0 U2 0 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0260-437X J9 J APPL TOXICOL JI J. Appl. Toxicol. PD JUN PY 1992 VL 12 IS 3 BP 185 EP 189 DI 10.1002/jat.2550120306 PG 5 WC Toxicology SC Toxicology GA HV664 UT WOS:A1992HV66400004 PM 1352790 ER PT J AU SELANDER, RK SMITH, NH LI, J BELTRAN, P FERRIS, KE KOPECKO, DJ RUBIN, FA AF SELANDER, RK SMITH, NH LI, J BELTRAN, P FERRIS, KE KOPECKO, DJ RUBIN, FA TI MOLECULAR EVOLUTIONARY GENETICS OF THE CATTLE-ADAPTED SEROVAR SALMONELLA-DUBLIN SO JOURNAL OF BACTERIOLOGY LA English DT Article ID MULTILOCUS ENZYME ELECTROPHORESIS; VI ANTIGEN EXPRESSION; VIRULENCE PLASMID; PARATYPHI-C; STRAINS; TYPHIMURIUM; PHYLOGENY; TYPHI; POLYSACCHARIDE; EPIDEMIOLOGY AB An electrophoretic analysis of allelic variation at 24 enzyme loci among 170 isolates of the serovar Salmonella dublin (serotype 1,9,12[Vi]:g,p:-) identified three electrophoretic types (Du 1, Du 3, and Du 4), marking three closely related clones, one of which (Du 1) is globally distributed and was represented by 95% of the randomly selected isolates. All but 1 of 114 nonmotile isolates of serotype 1,9,12:-:- recovered from cattle and swine in the United States were genotypically Du 1. The virulence capsular polysaccharide (Vi antigen) is confined to clone Du 3, which apparently is limited in distribution to France and Great Britain. For all 29 isolates of Du 3, positive signals were detected when genomic DNA was hybridized with a probe specific for the ViaB region, which contains the structurally determinant genes for the Vi antigen; and 23 of these isolates had been serologically typed as Vi positive. In contrast, all 30 isolates of Du 1 tested with the ViaB probe were negative. These findings strongly suggest that the ViaB genes were recently acquired by S. dublin via horizontal transfer and additive recombination. The clones of S. dublin are closely similar to the globally predominant clone (En 1) of Salmonella enteritidis (serotype 1,9,12:g,m:-) in both multilocus enzyme genotype and nucleotide sequence of the fliC gene encoding phase 1 flagellin. Comparative sequencing of fliC has revealed the molecular genetic basis for expression of the p and m flagellar epitopes by which these serovars are distinguished in the Kauffmann-White serological scheme of classification. C1 NATL VET SERV LABS,AMES,IA 50010. WALTER REED ARMY MED CTR,DEPT BACTERIAL IMMUNOL,WASHINGTON,DC 20307. RP SELANDER, RK (reprint author), PENN STATE UNIV,INST MOLEC EVOLUTIONARY GENET,UNIV PK,PA 16802, USA. RI Smith, Noel/C-6708-2011 FU NIAID NIH HHS [AI22144] NR 59 TC 55 Z9 57 U1 0 U2 3 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0021-9193 J9 J BACTERIOL JI J. Bacteriol. PD JUN PY 1992 VL 174 IS 11 BP 3587 EP 3592 PG 6 WC Microbiology SC Microbiology GA HX278 UT WOS:A1992HX27800024 PM 1592813 ER PT J AU WING, DA BASKIN, SI AF WING, DA BASKIN, SI TI MODIFIERS OF MERCAPTOPYRUVATE SULFURTRANSFERASE CATALYZED CONVERSION OF CYANIDE TO THIOCYANATE INVITRO SO JOURNAL OF BIOCHEMICAL TOXICOLOGY LA English DT Article DE CYANIDE; DETOXIFICATION; MERCAPTOPYRUVATE SULFURTRANSFERASE; THIOCYANATE PRODUCTION ID CENTRAL-NERVOUS-SYSTEM; TAURINE; KIDNEY AB The enzyme mercaptopyruvate sulfurtransferase appears to play an important role in the in vivo detoxification of cyanide. It does so by transferring sulfur to cyanide to produce thiocyanate, which is less toxic and may be excreted through the kidney. Several compounds were tested for their ability to affect the rate of enzyme catalyzed thiocyanate formation in vitro. The studies were carried out using both a partially purified bovine kidney extract and a highly purified enzyme preparation. Hypotaurine and methanesulfinic acid doubled sulfurtransferase activity in the partially purified extract at 30 mM, but inhibited the purified enzyme to 57% (hypotaurine) and 27% (methanesulfinic acid) of control activity at the same concentration. Pyruvate, phenylpyruvate, oxobutyrate, and oxoglutarate each inhibited the extract and purified forms of mercaptopyruvate sulfurtransferase. Phenylpyruvate was the most effective inhibitor, reducing activity to 0.2% of control values in the extract, and 11% of control values for purified MPST when added to the reaction at 30 mM. Other compounds tested (see Table 1) had a negligible effect on sulfurtransferase activity. A heat stable cofactor was found in boiled kidney extract which stimulated sulfurtransferase activity in the extract but inhibited sulfurtransferase activity in the purified enzyme, as was observed for hypotaurine and methanesulfinate. The boiled extract had no thiocyanate forming activity of its own. The cofactor operated in synergy with methanesulfinate, but independently of hypotaurine. C1 USA,MED RES INST CHEM DEF,DIV PHARMACOL,ABERDEEN PROVING GROUND,MD 21010. NR 25 TC 5 Z9 5 U1 2 U2 3 PU VCH PUBLISHERS INC PI DEERFIELD BEACH PA 303 NW 12TH AVE, DEERFIELD BEACH, FL 33442-1788 SN 0887-2082 J9 J BIOCHEM TOXICOL JI J. Biochem. Toxicol. PD SUM PY 1992 VL 7 IS 2 BP 65 EP 72 DI 10.1002/jbt.2570070203 PG 8 WC Toxicology SC Toxicology GA HZ742 UT WOS:A1992HZ74200002 PM 1404244 ER PT J AU NASEEM, SM WELLNER, RB PACE, JG AF NASEEM, SM WELLNER, RB PACE, JG TI THE ROLE OF CALCIUM-IONS FOR THE EXPRESSION OF RICIN TOXICITY IN CULTURED MACROPHAGES SO JOURNAL OF BIOCHEMICAL TOXICOLOGY LA English DT Article DE RICIN-TOXICITY; CALCIUM-REQUIREMENT; PROTEIN-SYNTHESIS; RECEPTOR-BINDING; CULTURED-MACROPHAGE ID A-CHAIN; DIPHTHERIA-TOXIN; CELLS; ENTRY; ABRIN; TRANSLOCATION; MODECCIN AB Ricin toxin, which consists of two distinct polypeptide moieties, A and B chains, is cytotoxic to the cultured macrophage cell line, J774A.1. Ricin is a protein synthesis inhibitor, and incubating macrophages for 4 hours with ricin (1 pM to 10 nM) in standard medium containing calcium and magnesium inhibited H-3-leucine incorporation into protein (97%, at 1 nM ricin). However, in Ca2+-free medium, protein synthesis was inhibited only 19%. EGTA pretreatment (to deplete intracellular calcium) also partly protected cells from protein synthesis inhibition, in spite of added calcium (2 mM) in the incubation medium. Decreased toxicity in the absence of extracellular calcium resulted from decreased toxin binding. Adding or deleting Mg2+ did not affect protein synthesis or binding of I-125-ricin in cultured macrophages. We conclude that calcium is required for ricin to exert its inhibitory effect on protein synthesis in cultured macrophages. RP NASEEM, SM (reprint author), USA,MED RES INST INFECT DIS,DIV PATHOPHYSIOL,FREDERICK,MD 21072, USA. NR 31 TC 7 Z9 8 U1 0 U2 3 PU VCH PUBLISHERS INC PI DEERFIELD BEACH PA 303 NW 12TH AVE, DEERFIELD BEACH, FL 33442-1788 SN 0887-2082 J9 J BIOCHEM TOXICOL JI J. Biochem. Toxicol. PD SUM PY 1992 VL 7 IS 2 BP 133 EP 138 DI 10.1002/jbt.2570070211 PG 6 WC Toxicology SC Toxicology GA HZ742 UT WOS:A1992HZ74200010 PM 1404243 ER PT J AU BEHRENS, JJ STANNARD, JP BUCKNELL, AL AF BEHRENS, JJ STANNARD, JP BUCKNELL, AL TI THE PREVALENCE OF SEROPOSITIVITY FOR HUMAN-IMMUNODEFICIENCY-VIRUS IN PATIENTS WHO HAVE SEVERE TRAUMA SO JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME LA English DT Article ID ILL EMERGENCY PATIENTS; HIV-1 INFECTION; AIDS AB Patients who have severe trauma have been reported to have a substantially increased rate of seropositivity for human immunodeficiency virus when compared with the general population. We reviewed the records of 1226 consecutive Code-3 trauma patients who were treated at our institution in San Antonio, Texas, between 1987 and 1989. All of the patients had serum drawn to be tested for the human immunodeficiency virus. In contrast with previously published studies, only 0.8 per cent of these trauma patients were seropositive. There was no appreciable difference between the prevalence of seropositivity in patients who sustained blunt trauma and those who sustained penetrating trauma. Exposure to human immunodeficiency virus for medical personnel who care for trauma patients remains a concern, but the risk may be lower than previously reported. C1 USA,MED CORPS,ORTHOPAED SURG SERV,FT SAM HOUSTON,TX 78234. BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234. NR 18 TC 3 Z9 3 U1 0 U2 0 PU JOURNAL BONE JOINT SURGERY INC PI NEEDHAM PA 20 PICKERING ST, NEEDHAM, MA 02192 SN 0021-9355 J9 J BONE JOINT SURG AM JI J. Bone Joint Surg.-Am. Vol. PD JUN PY 1992 VL 74A IS 5 BP 641 EP 645 PG 5 WC Orthopedics; Surgery SC Orthopedics; Surgery GA JD677 UT WOS:A1992JD67700002 PM 1624480 ER PT J AU SIMPSON, MB GEORGOPOULOS, G ORSINI, E EILERT, RE AF SIMPSON, MB GEORGOPOULOS, G ORSINI, E EILERT, RE TI AUTOLOGOUS TRANSFUSIONS FOR ORTHOPEDIC PROCEDURES AT A CHILDRENS HOSPITAL SO JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME LA English DT Article ID BLOOD-TRANSFUSION; ELECTIVE SURGERY; SPINAL SURGERY; SAFETY; DONATION; PROGRAM; DONORS AB We conducted a critical review of the use of autologous transfusions in orthopaedics at a tertiary-care children's hospital. The cases of 198 children who deposited blood before an orthopaedic operation were analyzed. There were 175 children who were enrolled in the program of preoperative deposit of autologous blood who later needed transfusion of blood; 73 per cent of them received only autologous blood. Seventy patients also had intraoperative salvage. We were unable to document a proved benefit of intraoperative salvage of blood in this group of patients. Forty patients had some difficulty donating autologous blood preoperatively, but these problems were rarely serious. Major human errors occurred in thirteen patients and resulted in some patients receiving homologous transfusions while autologous blood components were still available. Fifty-five (40 per cent) of all of the transfusions were administered in clinical circumstances that failed to meet generally accepted criteria for transfusion, and fifty-four (38 per cent) of the postoperative transfusions also failed to meet these criteria. This was true of the homologous transfusions in the study as well. Although an autologous blood transfusion is a generally safe procedure, it is not without risk, and human errors can occur. In light of the potential complications, surgeons should adhere to the standard indications for transfusion when administering autologous blood. C1 USA,MED CORPS,WASHINGTON,DC 20310. CHILDRENS HOSP,DENVER,CO 80218. NR 30 TC 42 Z9 43 U1 0 U2 0 PU JOURNAL BONE JOINT SURGERY INC PI NEEDHAM PA 20 PICKERING ST, NEEDHAM, MA 02192 SN 0021-9355 J9 J BONE JOINT SURG AM JI J. Bone Joint Surg.-Am. Vol. PD JUN PY 1992 VL 74A IS 5 BP 652 EP 658 PG 7 WC Orthopedics; Surgery SC Orthopedics; Surgery GA JD677 UT WOS:A1992JD67700004 PM 1624482 ER PT J AU HOFFER, MM JOHNSON, B AF HOFFER, MM JOHNSON, B TI SHRAPNEL WOUNDS IN CHILDREN SO JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME LA English DT Article AB Nineteen children who had open fractures and skin wounds of at least two centimeters due to shrapnel were followed for one to five weeks after they had been injured. All of the patients were managed with debridement at twenty-four to forty-eight-hour intervals and were given cephalosporin antibiotics. Fourteen patients did well. The wounds in the three patients who had the least severe soft-tissue injury were healing well at two weeks, and ten other patients were progressing to soft-tissue and osseous healing at five weeks. One patient had progressive but slower healing, and plastic reconstructive procedures would be advisable. Five patients had major problems. In one of these children, a wound continued to drain after six weeks. Three children had an amputation, and another child died due to a vascular injury. C1 USA,MED CORPS,WASHINGTON,DC 20310. NR 6 TC 7 Z9 7 U1 0 U2 0 PU JOURNAL BONE JOINT SURGERY INC PI NEEDHAM PA 20 PICKERING ST, NEEDHAM, MA 02192 SN 0021-9355 J9 J BONE JOINT SURG AM JI J. Bone Joint Surg.-Am. Vol. PD JUN PY 1992 VL 74A IS 5 BP 766 EP 769 PG 4 WC Orthopedics; Surgery SC Orthopedics; Surgery GA JD677 UT WOS:A1992JD67700016 PM 1624492 ER PT J AU MYERS, C COOPER, M STEIN, C LAROCCA, R WALTHER, MM WEISS, G CHOYKE, P DAWSON, N STEINBERG, S UHRICH, MM CASSIDY, J KOHLER, DR TREPEL, J LINEHAN, WM AF MYERS, C COOPER, M STEIN, C LAROCCA, R WALTHER, MM WEISS, G CHOYKE, P DAWSON, N STEINBERG, S UHRICH, MM CASSIDY, J KOHLER, DR TREPEL, J LINEHAN, WM TI SURAMIN - A NOVEL GROWTH-FACTOR ANTAGONIST WITH ACTIVITY IN HORMONE-REFRACTORY METASTATIC PROSTATE-CANCER SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Article ID FACTOR RECEPTOR; DOWN-REGULATION; ADRENAL-CORTEX; ANTIGEN; CELLS; TRANSFORMATION; ADENOCARCINOMA; HYPERPLASIA; INHIBITION; ACTIVATION C1 NIH,WARREN G MAGNUSON CLIN CTR,DEPT RADIOL,BETHESDA,MD 20892. NIH,WARREN G MAGNUSON CLIN CTR,DEPT NURSING,BETHESDA,MD 20892. NIH,WARREN G MAGNUSON CLIN CTR,DEPT PHARM,BETHESDA,MD 20892. WALTER REED ARMY MED CTR,DIV HEMATOL ONCOL,WASHINGTON,DC 20307. NCI,DIV CANC TREATMENT,CLIN ONCOL PROGRAM,BIOSTAT & DATA MANAGEMENT SECT,BETHESDA,MD 20892. NCI,DIV CANC TREATMENT,CLIN ONCOL PROGRAM,SURG BRANCH,BETHESDA,MD 20892. RP MYERS, C (reprint author), NCI,DIV CANC TREATMENT,CLIN ONCOL PROGRAM,CLIN PHARMACOL BRANCH,BLDG 10,ROOM 12C103,BETHESDA,MD 20892, USA. NR 43 TC 227 Z9 227 U1 0 U2 1 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0732-183X J9 J CLIN ONCOL JI J. Clin. Oncol. PD JUN PY 1992 VL 10 IS 6 BP 881 EP 889 PG 9 WC Oncology SC Oncology GA HW164 UT WOS:A1992HW16400003 PM 1375283 ER PT J AU OBRIEN, TK AF OBRIEN, TK TI RESIDUAL THERMAL AND MOISTURE INFLUENCES ON THE ANALYSIS OF LOCAL DELAMINATIONS SO JOURNAL OF COMPOSITES TECHNOLOGY & RESEARCH LA English DT Article DE RESIDUAL THERMAL STRESS; HYGROSCOPIC STRESS; MOISTURE; STRAIN ENERGY RELEASE RATE; DELAMINATION; MATRIX CRACK AB An analysis using laminated plate theory is developed to calculate the strain energy release rate associated with local delaminations originating at off-axis, angle-ply, matrix cracks in laminates subjected to uniaxial loads. The analysis includes the contribution of residual thermal and moisture stresses to the strain energy released. Examples are calculated for the strain energy release rate associated with local delaminations originating at 90-degrees and angle-ply (non 90-degrees) matrix-ply cracks in glass-epoxy and graphite-epoxy laminates. The solution developed may be used to assess the relative contribution of mechanical, residual thermal, and moisture stresses on the strain energy release rate for local delamination for a variety of layups and materials. C1 USA,NASA,LANGLEY RES CTR,AEROSTRUCT DIRECTORATE,HAMPTON,VA 23665. NR 11 TC 3 Z9 3 U1 0 U2 0 PU AMER SOC TESTING MATERIALS PI W CONSHOHOCKEN PA 100 BARR HARBOR DR, W CONSHOHOCKEN, PA 19428-2959 SN 0884-6804 J9 J COMPOS TECH RES JI J. Compos. Technol. Res. PD SUM PY 1992 VL 14 IS 2 BP 86 EP 94 PG 9 WC Materials Science, Composites; Polymer Science SC Materials Science; Polymer Science GA JY516 UT WOS:A1992JY51600004 ER PT J AU PASHLEY, EL AF PASHLEY, EL TI EFFECTS OF CO2-LASER ENERGY ON DENTIN PERMEABILITY SO JOURNAL OF ENDODONTICS LA English DT Article ID CO2-LASER AB The effect of a CO2 laser on the structure and permeability of smear layer-covered human dentin was evaluated in vitro. Three different energy levels were used (11, 113, and 566 J/cm2). The lowest exposure to the laser energy increased dentin permeability, measured as a hydraulic conductance, due to partial loss of the superficial smear layer and smear plugs. The intermediate energy level also increased dentin permeability by crater formation, making the dentin thinner. The lack of uniform glazing of the surface of the crater, leaving its surface porous and in communication with the underlying dentinal tubules also contributed to the increase in dentin permeability seen with the intermediate laser energy. The highest laser energy produced complete glazing of the crater surfaces and sealed the dentinal tubules beneath the crater. However, it also completely removed the smear layer in a halo zone about 100-mu-m wide around each crater which increased the permeability of the pericrater dentin at the same time it decreased the permeability of the dentin within the crater. The combined use of scanning electron microscopy and permeability measurements provides important complementary information that is essential in evaluating the effects of lasers on dentin. C1 MED COLL GEORGIA,SCH DENT,DEPT ORAL DIAG,AUGUSTA,GA 30912. MED COLL GEORGIA,SCH DENT,PATIENT SERV,AUGUSTA,GA 30912. DWIGHT D EISENHOWER ARMY MED CTR,DEPT CLIN INVEST,FT GORDON,GA 30905. COLUMBIA UNIV,SCH ORAL & DENT SURG,DEPT ENDODONT,NEW YORK,NY 10027. RP PASHLEY, EL (reprint author), MED COLL GEORGIA,SCH DENT,DEPT ORAL BIOL PHYSIOL,AUGUSTA,GA 30912, USA. FU NIDCR NIH HHS [DE0121, DE06427, DE05605] NR 15 TC 39 Z9 42 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0099-2399 J9 J ENDODONT JI J. Endod. PD JUN PY 1992 VL 18 IS 6 BP 257 EP 262 DI 10.1016/S0099-2399(06)80951-9 PG 6 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA HW973 UT WOS:A1992HW97300001 PM 1402582 ER PT J AU PHILLIPS, JL WELLER, RN KULILD, JC AF PHILLIPS, JL WELLER, RN KULILD, JC TI THE MENTAL FORAMEN .2. RADIOGRAPHIC POSITION IN RELATION TO THE MANDIBULAR 2ND PREMOLAR SO JOURNAL OF ENDODONTICS LA English DT Article AB Seventy-five adult human mandibles were radiographed with a paralleling technique to determine the ability to visualize the mental foramen as well as its size and position. The foramen was seen on 75% of the horizontal periapical radiographs examined. When the foramen was not visualized, is was usually below the inferior edge of the film. The radiographic size of the foramen was smaller than the anatomical size previously reported. The position of the mental foramen was usually mesial and below the radiographic apex of the second premolar. C1 USA,DENT ACT,POSTGRAD PROGRAM,ENDODONT RESIDENCY PROGRAM,FT GORDON,GA 30905. NR 5 TC 29 Z9 29 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0099-2399 J9 J ENDODONT JI J. Endod. PD JUN PY 1992 VL 18 IS 6 BP 271 EP 274 DI 10.1016/S0099-2399(06)80953-2 PG 4 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA HW973 UT WOS:A1992HW97300003 PM 1402584 ER PT J AU CUNNINGHAM, CJ SENIA, ES AF CUNNINGHAM, CJ SENIA, ES TI A 3-DIMENSIONAL STUDY OF CANAL CURVATURES IN THE MESIAL ROOTS OF MANDIBULAR MOLARS SO JOURNAL OF ENDODONTICS LA English DT Article ID INVITRO METHOD; MORPHOLOGY; INSTRUMENTATION; ANATOMY AB The degree and configuration of canal curvature was studied in the mesial roots of 100 randomly selected mandibular first and second molars. The teeth were radiographed in buccolingual (clinical) and mesiodistal (proximal) directions with #8 K files in place. One hundred percent of the specimens demonstrated curvature in both views. No correlation in degree of curvature was found to exist between the clinical and proximal views. Secondary curvature, in a direction opposite to that of the principle curve, was seen more frequently in the proximal view. In the proximal view, canals exhibited greater mean curvature than in the clinical view 38% of the time. Weine type II morphology (two canals, one foramen) demonstrated the greatest range in canal curvature when viewed from the proximal. Coronal flaring with Canal Master rotary instruments to a level just coronal to the curve significantly reduced the severity of curvatures in both views for most cases. C1 USAF,MED CTR,LACKLAND AFB,TX 78236. USA,ADV EDUC PROGRAM ENDODONT,WASHINGTON,DC 20438. RP CUNNINGHAM, CJ (reprint author), UNIV TEXAS,HLTH SCI CTR,DEPT ENDODONT,SAN ANTONIO,TX 78284, USA. NR 19 TC 63 Z9 76 U1 0 U2 2 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0099-2399 J9 J ENDODONT JI J. Endod. PD JUN PY 1992 VL 18 IS 6 BP 294 EP 300 DI 10.1016/S0099-2399(06)80957-X PG 7 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA HW973 UT WOS:A1992HW97300007 PM 1402588 ER PT J AU MCDONALD, MN VIRE, DE AF MCDONALD, MN VIRE, DE TI CHLOROFORM IN THE ENDODONTIC OPERATORY SO JOURNAL OF ENDODONTICS LA English DT Article ID APICAL SEAL; SOLVENTS AB This article reviews the role chloroform has played in dentistry and describes an occupational health clinical investigation into the possible hazards of chloroform use in the operatory. Due to a Food and Drug Administration ban on drugs and cosmetics containing chloroform, there has been some confusion as to whether the use of chloroform in the practice of dentistry is considered unsafe or has been prohibited. Utilizing common endodontic treatment methods employing chloroform, this study reports no negative health effects to the dentist or assistant and air vapor levels well below Occupational Health and Safety Administration mandated maximum levels. The report concludes that, with careful and controlled use, chloroform can be a useful adjunct in the practice of dentistry. The Food and Drug Administration has no jurisdiction over a dentist's use of chloroform in clinical practice and has not proven that chloroform is a human carcinogen. C1 USA,DENT CORPS,FT SILL,OK. NR 12 TC 26 Z9 28 U1 0 U2 1 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0099-2399 J9 J ENDODONT JI J. Endod. PD JUN PY 1992 VL 18 IS 6 BP 301 EP 303 DI 10.1016/S0099-2399(06)80958-1 PG 3 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA HW973 UT WOS:A1992HW97300008 PM 1402589 ER PT J AU FOSTER, KH PRIMACK, PD KULILD, JC AF FOSTER, KH PRIMACK, PD KULILD, JC TI ODONTOGENIC CUTANEOUS SINUS TRACT SO JOURNAL OF ENDODONTICS LA English DT Article AB Patients with odontogenic cutaneous sinus tracts usually seek treatment from a physician instead of a dentist and the etiology is frequently misdiagnosed. This case report describes a patient who sought treatment f rom a dentist because of a history of a previous cutaneous swelling on the ipsilateral side of his cheek. The etiology of the present swelling was a carious tooth. The patient was treated concurrently with both nonsurgical endodontic therapy and transcutaneous drainage by aspiration. This method of drainage precluded possible spontaneous drainage and avoided damage to proximal anatomical structures which may have occurred if an incision had been used. C1 USA,DENT ACT,POSTGRAD PROGRAM,ENDODONT RESIDENCY PROGRAM,FT GORDON,GA 30905. NR 10 TC 9 Z9 10 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0099-2399 J9 J ENDODONT JI J. Endod. PD JUN PY 1992 VL 18 IS 6 BP 304 EP 306 DI 10.1016/S0099-2399(06)80959-3 PG 3 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA HW973 UT WOS:A1992HW97300009 PM 1402590 ER PT J AU MCFARLAND, DG BARKO, JW MCCREARY, NJ AF MCFARLAND, DG BARKO, JW MCCREARY, NJ TI EFFECTS OF SEDIMENT FERTILITY AND INITIAL PLANT-DENSITY ON GROWTH OF HYDRILLA-VERTICILLATA (LF) ROYLE AND POTAMOGETON-NODOSUS POIRET SO JOURNAL OF FRESHWATER ECOLOGY LA English DT Article ID FRESH-WATER MACROPHYTES; SUBMERSED MACROPHYTES; AQUATIC MACROPHYTES; TEMPERATURE; MORPHOLOGY; LIGHT; COMPETITION AB In a six-week greenhouse investigation, variations in the growth of Hydrilla verticillata (L.f.) Royle and Potamogeton nodosus Poiret (= P. americanus) were examined separately under high and low levels of sediment fertility and plant density. For both species, diminished biomass production and shoot lengths accompanied increased root-to-shoot ratios on infertile sediment. In corresponding density/fertility treatments, Potamogeton consistently produced greater total biomass and root-to-shoot ratios than Hydrilla. Shoot production was similar between species on infertile sediment, but on fertile sediment, Potamogeton produced nearly twice as many shoots as Hydrilla. High plant density, combined with high sediment fertility, resulted in a significant reduction in aboveground biomass of individual Hydrilla plants. However, at neither level of sediment fertility did the biomass of individual Potamogeton plants show significant density effects. Growth responses under nutrient-poor sediment conditions revealed different survival strategies of the two species. Hydrilla maximized shoot production at the expense of shoot elongation as a means of lateral expansion, while Potamogeton allocated proportionately greater biomass below ground to enhance nutrition. C1 LAFAYETTE COLL,DEPT BIOL,EASTON,PA 18042. RP MCFARLAND, DG (reprint author), USA,ENGINEER WATERWAYS EXPT STN,ENVIRONM LAB,VICKSBURG,MS 39180, USA. NR 27 TC 7 Z9 7 U1 1 U2 2 PU OIKOS PUBL INC PI LA CROSSE PA PO BOX 2558, LA CROSSE, WI 54601 SN 0270-5060 J9 J FRESHWATER ECOL JI J. Freshw. Ecol. PD JUN PY 1992 VL 7 IS 2 BP 191 EP 200 DI 10.1080/02705060.1992.9664684 PG 10 WC Ecology; Limnology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA JG369 UT WOS:A1992JG36900009 ER PT J AU DORTCH, MS CHAPMAN, RS ABT, SR AF DORTCH, MS CHAPMAN, RS ABT, SR TI APPLICATION OF 3-DIMENSIONAL LAGRANGIAN RESIDUAL TRANSPORT SO JOURNAL OF HYDRAULIC ENGINEERING-ASCE LA English DT Article ID SAN-FRANCISCO BAY; ESTUARIES; CURRENTS; CALIFORNIA AB Three-dimensional Lagrangian residual circulation computed from an intratidal hydrodynamic model is used to drive an intertidal water-quality transport model. The sum of the Eulerian residual and Stokes' drift is used as a first-order approximation for the Lagrangian residual current. The Stokes' drift approximates residual currents induced by the nonlinear interactions of the tidal currents. Computed residual velocities show close agreement with a two-dimensional (vertical-longitudinal) analytical result. The methodology is applied to Chesapeake Bay for the entire year of 1985. Salinity computed with the intertidal transport model (i.e., with Lagrangian residuals) shows good agreement with observed salinity data and that computed with the intratidal hydrodynamic model. The basic effect of thc Stokes drift is to transport water mass (e.g., salinity) up estuary. The procedures provide a practical means of interfacing intratidal hydrodynamic model information to water-quality models for making long-term, intertidal transport computations for weakly nonlinear tidal systems. C1 RAY CHAPMAN & ASSOC,VICKSBURG,MS 39180. COLORADO STATE UNIV,DEPT CIVIL ENGN,FT COLLINS,CO 80523. RP DORTCH, MS (reprint author), USAE WATERWAYS EXPT STN,ENVIR LAB,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 37 TC 18 Z9 20 U1 0 U2 1 PU ASCE-AMER SOC CIVIL ENGINEERS PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-9429 J9 J HYDRAUL ENG-ASCE JI J. Hydraul. Eng.-ASCE PD JUN PY 1992 VL 118 IS 6 BP 831 EP 848 DI 10.1061/(ASCE)0733-9429(1992)118:6(831) PG 18 WC Engineering, Civil; Engineering, Mechanical; Water Resources SC Engineering; Water Resources GA HV712 UT WOS:A1992HV71200001 ER PT J AU MAYNORD, ST AF MAYNORD, ST TI FLOW RESISTANCE OF RIPRAP - CLOSURE SO JOURNAL OF HYDRAULIC ENGINEERING-ASCE LA English DT Discussion RP MAYNORD, ST (reprint author), USA ENGR WATERWAYS EXPT STN,HYDR LAB,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASCE-AMER SOC CIVIL ENGINEERS PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-9429 J9 J HYDRAUL ENG-ASCE JI J. Hydraul. Eng.-ASCE PD JUN PY 1992 VL 118 IS 6 BP 954 EP 954 DI 10.1061/(ASCE)0733-9429(1992)118:6(954.2) PG 1 WC Engineering, Civil; Engineering, Mechanical; Water Resources SC Engineering; Water Resources GA HV712 UT WOS:A1992HV71200017 ER PT J AU SUAREHAWARATANA, P SINGHARAJ, P TAYLOR, DN HOGE, C TROFA, A KUVANONT, K MIGASENA, S PITISUTTITHAM, P LIM, YL LOSONSKY, G KAPER, JB WASSERMAN, SS CRYZ, S ECHEVERRIA, P LEVINE, MM AF SUAREHAWARATANA, P SINGHARAJ, P TAYLOR, DN HOGE, C TROFA, A KUVANONT, K MIGASENA, S PITISUTTITHAM, P LIM, YL LOSONSKY, G KAPER, JB WASSERMAN, SS CRYZ, S ECHEVERRIA, P LEVINE, MM TI SAFETY AND IMMUNOGENICITY OF DIFFERENT IMMUNIZATION REGIMENS OF CVD 103-HGR LIVE ORAL CHOLERA VACCINE IN SOLDIERS AND CIVILIANS IN THAILAND SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID IMMUNITY; ADULTS; OGAWA AB Attenuated Vibrio cholerae oral vaccine CVD 103-HgR was well tolerated by 324 Thai soldiers and civilians. Most received a single 5 x 10(8) cfu dose, while 40 each received one or two 5 x 10(9) cfu doses. Vibriocidal antibody (the best correlate of immunity) seroconversion was lower in soldiers than civilians (P < .001). Increasing the vaccine dose to 5 x 1O(9) cfu raised the geometric mean titer (P < .00 1). A second 5 x 1O(9) cfu dose one week later did not notably increase seroconversions. Likelihood of seroconversion was inversely correlated with baseline vibriocidal titer (P < .001). CVD 103-HgR caused seroconversion in most subjects with baseline titers less-than-or-equal-to 1:40, including 100% of civilians after one 5 x 10(8) cfu dose, 79% of soldiers after one 5 x 10(9) cfu dose, and 45% of soldiers after one 5 x 10(8) cfu dose. In persons with elevated baseline titers, vibriocidal antibody seroconversion is not a sensitive measure of whether vaccine has boosted intestinal immunity; for such subjects, other measurements must be used. Study regimens in endemic areas should use a single 5 x 10(9) cfu dose. C1 UNIV MARYLAND,SCH MED,CTR VACCINE DEV,10 S PINE ST,BALTIMORE,MD 21201. MAHIDOL UNIV,FAC TROP MED,CTR VACCINE TRIAL,BANGKOK 10700,THAILAND. WALTER REED ARMY MED CTR,DEPT ENTER INFECT,WASHINGTON,DC 20307. SWISS SERUM & VACCINE INST,BERN,SWITZERLAND. OI Kaper, James/0000-0003-0715-2907 FU NIAID NIH HHS [AI-62528] NR 25 TC 75 Z9 76 U1 0 U2 1 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD JUN PY 1992 VL 165 IS 6 BP 1042 EP 1048 PG 7 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA HV960 UT WOS:A1992HV96000009 PM 1583321 ER PT J AU CARL, M HAWKINS, R COULSON, N LOWE, J ROBERTSON, DL NELSON, WM TITBALL, RW WOODY, JN AF CARL, M HAWKINS, R COULSON, N LOWE, J ROBERTSON, DL NELSON, WM TITBALL, RW WOODY, JN TI DETECTION OF SPORES OF BACILLUS-ANTHRACIS USING THE POLYMERASE CHAIN-REACTION SO JOURNAL OF INFECTIOUS DISEASES LA English DT Note AB The polymerase chain reaction (PCR) was used to identify spores of Bacillus anthracis. By using an assay capable of amplifying a 1247-bp fragment from the gene that encodes the edema factor of B. anthracis, as few as 1O(3) copies of a plasmid containing the edema factor gene and as few as 2 x 10(4) spores were detected. Subjecting the product of this PCR to a second PCR designed to amplify a 208-bp fragment nested within the 1247-bp product improved detection to a single plasmid copy per PCR and to two spores of B. anthracis per PCR. C1 UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. USA,MED RES INST INFECT DIS,FREDERICK,MD 21701. CHEM & BIOL DEF ESTAB,SALISBURY,ENGLAND. BRIGHAM YOUNG UNIV,PROVO,UT 84602. RP CARL, M (reprint author), USN,MED RES INST,NAVAL MED RES & DEV COMMAND,BLDG 17A,ROOM 316,BETHESDA,MD 20814, USA. NR 13 TC 21 Z9 21 U1 0 U2 1 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD JUN PY 1992 VL 165 IS 6 BP 1145 EP 1148 PG 4 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA HV960 UT WOS:A1992HV96000028 PM 1583336 ER PT J AU MARTIN, A HEYES, MP SALAZAR, AM KAMPEN, DL WILLIAMS, J LAW, WA COATS, ME MARKEY, SP AF MARTIN, A HEYES, MP SALAZAR, AM KAMPEN, DL WILLIAMS, J LAW, WA COATS, ME MARKEY, SP TI PROGRESSIVE SLOWING OF REACTION-TIME AND INCREASING CEREBROSPINAL-FLUID CONCENTRATIONS OF QUINOLINIC ACID IN HIV-INFECTED INDIVIDUALS SO JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES LA English DT Article ID AIDS DEMENTIA COMPLEX; IMMUNODEFICIENCY-VIRUS-INFECTION; CHOICE REACTION-TIME; HUNTINGTONS-DISEASE; ALZHEIMERS-DISEASE; KYNURENIC ACID; L-TRYPTOPHAN; RAT-BRAIN; LESIONS; SYSTEM AB Neuropsychological functioning and cerebrospinal fluid concentrations of an endogenous neurotoxin, quinolinic acid (QUIN) were evaluated in 52 HIV-positive individuals (71 % without constitutional symptoms) and 33 HIV-seronegative controls (including 15 psychiatric patients with adjustment disorders). Although the HIV-positive subjects did not differ from controls on standard neuropsychological tests, simple and choice reactions times (RT) were slow at initial evaluation (P < 0.01) and became progressively slower at 6-month reevaluation (P < 0.05). Cerebrospinal fluid (CSF) QUIN was elevated at initial evaluation and increased during the 6-month interval (P < 0.05). Moreover, during this 6-month interval, progressive slowing of RT was highly correlated with increasing levels of CSF QUIN (r = 0.85, df = 15, P < 0.0001) but not with changes in mood, constitutional symptoms, or CD4 cell count. These findings suggest that RT may provide a sensitive behavioral measure of relatively early central nervous system involvement in HIV-infected individuals and that QUIN may play an important role in the pathogenesis of HIV-related neurological dysfunction. C1 HENRY M JACKSON FDN ADV MILIT MED,ROCKVILLE,MD. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,DEPT NEUROL,BETHESDA,MD 20814. RP MARTIN, A (reprint author), NIMH,CLIN SCI LAB,BLDG 10,ROOM 3D-41,BETHESDA,MD 20892, USA. RI martin, alex/B-6176-2009 NR 49 TC 97 Z9 100 U1 0 U2 2 PU AMER PSYCHIATRIC ASSOCIATION PI WASHINGTON PA 1400 K ST NW, WASHINGTON, DC 20005 SN 0895-0172 J9 J NEUROPSYCH CLIN N JI J. Neuropsychiatr. Clin. Neurosci. PD SUM PY 1992 VL 4 IS 3 BP 270 EP 279 PG 10 WC Clinical Neurology; Neurosciences; Psychiatry SC Neurosciences & Neurology; Psychiatry GA JG128 UT WOS:A1992JG12800005 PM 1386770 ER PT J AU GARY, JJ DONOVAN, M GARNER, FT FAULK, JE AF GARY, JJ DONOVAN, M GARNER, FT FAULK, JE TI REHABILITATION WITH CALVARIAL BONE-GRAFTS AND OSSEOINTEGRATED IMPLANTS AFTER PARTIAL MAXILLARY RESECTION - A CLINICAL REPORT SO JOURNAL OF PROSTHETIC DENTISTRY LA English DT Article ID INVERTED PAPILLOMA C1 WILLIAM BEAUMONT ARMY MED CTR,FT BLISS,TX. NR 4 TC 14 Z9 16 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0022-3913 J9 J PROSTHET DENT JI J. Prosthet. Dent. PD JUN PY 1992 VL 67 IS 6 BP 743 EP 746 DI 10.1016/0022-3913(92)90574-T PG 4 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA HX263 UT WOS:A1992HX26300002 PM 1403852 ER PT J AU RENDER, PJ FONDAK, JT AF RENDER, PJ FONDAK, JT TI A SURGICAL GUIDE FOR IMPLANT PLACEMENT SO JOURNAL OF PROSTHETIC DENTISTRY LA English DT Article AB Mounted diagnostic casts aid in determining whether sufficient space exists for a fixed cantilevered implant prosthesis. These casts are also used to construct a surgical guide. Such a technique is described. RP RENDER, PJ (reprint author), USA,AREA DENT LAB,FT SAM HOUSTON,TX 78234, USA. NR 4 TC 2 Z9 2 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0022-3913 J9 J PROSTHET DENT JI J. Prosthet. Dent. PD JUN PY 1992 VL 67 IS 6 BP 831 EP 832 DI 10.1016/0022-3913(92)90594-Z PG 2 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA HX263 UT WOS:A1992HX26300022 PM 1403871 ER PT J AU HONDRUM, SO AF HONDRUM, SO TI A REVIEW OF THE STRENGTH PROPERTIES OF DENTAL CERAMICS SO JOURNAL OF PROSTHETIC DENTISTRY LA English DT Article ID FUSED-TO-METAL; PORCELAIN JACKET CROWNS; COMPRESSIVE STRENGTHS; FRACTURE-TOUGHNESS; FLEXURAL STRENGTH; TWIN FOIL; BIOMATERIALS; PERFORMANCE; STRESSES AB New ceramic materials for restorative dentistry have been developed and introduced in recent years. This article reviews advantages and disadvantages of dental ceramics, concentrating on strength properties. Included are factors affecting the strength of dental ceramic materials and the most common mechanisms for increasing the strength of dental ceramics. The properties of presently available materials such as dispersion-strengthened ceramics, cast ceramics, and foil-reinforced materials are discussed. Current research efforts to improve the fracture resistance of ceramic restorative materials are reviewed. A description of methods to evaluate the strength of ceramics is included, as is a caution concerning the interpretation of strength data reported in the literature. RP HONDRUM, SO (reprint author), KIMBROUGH ARMY COMMUNITY HOSP,USA,INST DENT RES,SGRD,UDR,DM,FT GEORGE G MEADE,MD 20755, USA. NR 76 TC 49 Z9 51 U1 0 U2 4 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0022-3913 J9 J PROSTHET DENT JI J. Prosthet. Dent. PD JUN PY 1992 VL 67 IS 6 BP 859 EP 865 DI 10.1016/0022-3913(92)90602-7 PG 7 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA HX263 UT WOS:A1992HX26300030 PM 1403879 ER PT J AU NETTI, CA SKIRVIN, DR PHELAN, PR JONES, TK AF NETTI, CA SKIRVIN, DR PHELAN, PR JONES, TK TI A SIMPLIFIED INTRAORAL SURVEYING DEVICE SO JOURNAL OF PROSTHETIC DENTISTRY LA English DT Article ID ABUTMENT AB This article describes an easily made and used intraoral surveying device that can aid the dentist in transferring needed preparation information from the diagnostic cast. This device also allows checking of the preparations as they are progressing. The device consists of a Proxabrush handle and a drafting lead. C1 USA,DENT ACTIV,FT RILEY,KS. MED DET 769TH,AUGSBURG,GERMANY. MED DENT 87TH,ERLANGEN,GERMANY. RP NETTI, CA (reprint author), USA,AREA DENT LAB,BLDG 2059 BUCK RD,FT SAM HOUSTON,TX 78234, USA. NR 11 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0022-3913 J9 J PROSTHET DENT JI J. Prosthet. Dent. PD JUN PY 1992 VL 67 IS 6 BP 870 EP 872 DI 10.1016/0022-3913(92)90604-9 PG 3 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA HX263 UT WOS:A1992HX26300032 PM 1403881 ER PT J AU MCCARTNEY, JW AF MCCARTNEY, JW TI CALCULUS AND PLAQUE REMOVAL FROM OSSEOINTEGRATED IMPLANT TITANIUM ABUTMENTS SO JOURNAL OF PROSTHETIC DENTISTRY LA English DT Article RP MCCARTNEY, JW (reprint author), WALTER REED ARMY MED CTR,AREA DENT LAB,WASHINGTON,DC 20307, USA. NR 1 TC 1 Z9 1 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0022-3913 J9 J PROSTHET DENT JI J. Prosthet. Dent. PD JUN PY 1992 VL 67 IS 6 BP 896 EP 896 DI 10.1016/0022-3913(92)90614-G PG 1 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA HX263 UT WOS:A1992HX26300042 PM 1403891 ER PT J AU SHULMAN, JD CARPENTER, WM LEWIS, DL AF SHULMAN, JD CARPENTER, WM LEWIS, DL TI THE PREVALENCE OF RECURRENT HERPES LABIALIS DURING AN ARMY HOT WEATHER EXERCISE SO JOURNAL OF PUBLIC HEALTH DENTISTRY LA English DT Article DE HERPES LABIALIS; LIP DISEASES; PHOTOSENSITIVITY DISORDERS; ORAL HEALTH; OCCUPATIONAL DISEASES; EPIDEMIOLOGY ID SIMPLEX VIRUS; SUNSCREEN; MUCOSA AB A survey was performed on 1,062 of 2,500 (42%) Army personnel participating in a desert training exercise at Fort Irwin, California, in September 1983. The prevalence of recurrent herpes labialis (RHL) and chapped lips was observed during the third week of a four-week training period. Complexion, sex, lip protectant use, age, and time spent outdoors were obtained by observation and interview. Recurrent herpes labialis was found in 46 subjects (4%). Stratified analysis and stepwise logistic regression were used to identify risk factors associated with RHL and to determine the prevalence odds ratios (POR). Risk factors with statistically significant associations with RHL were lip protectant use (POR=0.19), chapped lips (POR=2.87), being female (POR=5.00), and light complexion (POR=2.48). These findings strongly support the use of lip protectants during prolonged exposure to hot, dry climates as a prophylaxis against recurrent herpes labialis. Additional studies should focus on excitatory factors of RHL; and clinical trials of the efficacy of the lip protectants to protect against RHL and chapped lips should be undertaken. C1 USA,DENT CORPS,FT SAM HOUSTON,TX 78234. UNIV PACIFIC,DEPT DIAGNOST SCI,SAN FRANCISCO,CA 94115. USA,DENT CORPS,SAN FRANCISCO,CA 94129. USA,DENT CORPS,FT GORDON,GA 30905. USA,DENT ACTIV,FT GORDON,GA 30905. RP SHULMAN, JD (reprint author), USA,HLTH CARE STUDIES & CLIN INVEST ACTIV,FT SAM HOUSTON,TX 78234, USA. NR 24 TC 6 Z9 7 U1 1 U2 1 PU AAPHD NATIONAL OFFICE PI RICHMOND PA J PUBLIC HEALTH DENT 10619 JOUSTING LANE, RICHMOND, VA 23235 SN 0022-4006 J9 J PUBLIC HEALTH DENT JI J. Public Health Dent. PD SUM PY 1992 VL 52 IS 4 BP 198 EP 203 DI 10.1111/j.1752-7325.1992.tb02273.x PG 6 WC Dentistry, Oral Surgery & Medicine; Public, Environmental & Occupational Health SC Dentistry, Oral Surgery & Medicine; Public, Environmental & Occupational Health GA JJ728 UT WOS:A1992JJ72800002 PM 1512743 ER PT J AU FARLEY, GL DICKINSON, LC AF FARLEY, GL DICKINSON, LC TI REMOVAL OF SURFACE LOOP FROM STITCHED COMPOSITES CAN IMPROVE COMPRESSION AND COMPRESSION-AFTER-IMPACT STRENGTHS SO JOURNAL OF REINFORCED PLASTICS AND COMPOSITES LA English DT Article AB Stitching through-the-thickness (TTT) of composite materials produces a surface loop of yarn between successive penetrations. The surface loop is pressed into the surface layers of the composite material during the curing of the laminate, kinking the in-plane fibers near the surface of the material. The compression strength and compression-after-impact (CAI) strengths of carbon-epoxy specimens were measured with and without the surface loop. Removal of the surface loop had no influence on failure mode or failure mechanism, but did significantly increase the compression and CAI strengths. C1 LOCKHEED ENGN & SCI CO,LANGLEY RES CTR,HAMPTON,VA 23665. RP FARLEY, GL (reprint author), USA,AEROSTRUCT DIRECTORATE,LANGLEY RES CTR,HAMPTON,VA 23665, USA. NR 8 TC 31 Z9 31 U1 1 U2 1 PU TECHNOMIC PUBL CO INC PI LANCASTER PA 851 NEW HOLLAND AVE, BOX 3535, LANCASTER, PA 17604 SN 0731-6844 J9 J REINF PLAST COMP JI J. Reinf. Plast. Compos. PD JUN PY 1992 VL 11 IS 6 BP 633 EP 642 DI 10.1177/073168449201100604 PG 10 WC Materials Science, Composites; Polymer Science SC Materials Science; Polymer Science GA HZ620 UT WOS:A1992HZ62000004 ER PT J AU CRADDOCK, JN WHITE, MJ AF CRADDOCK, JN WHITE, MJ TI SOUND-PROPAGATION OVER A SURFACE WITH VARYING IMPEDANCE - A PARABOLIC EQUATION APPROACH SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Article ID POINT-SOURCE; DIFFRACTION; ATMOSPHERE; SCREENS; NOISE AB This paper describes modifications to a finite element solution for the wide angle parabolic equation (PE). The modifications to the PE allow the computationally efficient solution of the problem of sound propagation over ground whose impedance varies with range. In particular, the set of linear algebraic equations that propagate the field outward in range is solved with a UL (upper, lower triangular) decomposition, instead of the standard LU (lower, upper triangular) scheme. This approach allows the change in impedance to affect only a single element in the decomposition. Consequently, all previous calculations in the decomposition can be saved in proceeding from one range step to the next. Results are presented for several cases, in which the ground suffers an abrupt change in acoustic impedance at some distance along the propagation path. Comparisons to existing experimental data are made and the method presented here matches the published data quite well. Other diffraction cases are presented for which no experimental data are available, however the results are fairly self-consistent and serve to indicate the versatility of this method. The approach described in this paper represents an accurate and efficient method for solving problems involving sound propagation over ground having a range-dependent surface impedance. C1 USA,CONSTRUCT ENGN RES LAB,CHAMPAIGN,IL 61826. RP CRADDOCK, JN (reprint author), SO ILLINOIS UNIV,CARBONDALE,IL 62901, USA. RI White, Michael/B-3612-2009 OI White, Michael/0000-0001-8450-9135 NR 18 TC 9 Z9 9 U1 0 U2 2 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0001-4966 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD JUN PY 1992 VL 91 IS 6 BP 3184 EP 3191 DI 10.1121/1.403758 PG 8 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA HX655 UT WOS:A1992HX65500011 ER PT J AU JAMES, WD ROSENTHAL, LE BRANCACCIO, RR MARKS, JG AF JAMES, WD ROSENTHAL, LE BRANCACCIO, RR MARKS, JG TI AMERICAN-ACADEMY-OF-DERMATOLOGY PATCH TESTING SURVEY - USE AND EFFECTIVENESS OF THIS PROCEDURE SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Article AB The results of an American Academy of Dermatology (AAD)-sponsored survey on the use and effectiveness of patch testing are presented. Academy members' responses indicate that 27% do not patch test at all. Reasons given for not testing included (1) the patient history was adequate for diagnosis, (2) patch testing was too time-consuming, and (3) reimbursement was not sufficient. Dermatologists in residency training programs who responded to a similar survey are testing frequently and report a high degree of positivity and relevancy among tests applied. Recommendations are presented with a focus toward increasing interest in patch testing among the membership. C1 AMER ACAD DERMATOL,POB 4014,SCHAUMBURG,IL 60168. WALTER REED ARMY MED CTR,DEPT MED,DERMATOL SERV,WASHINGTON,DC 20307. NR 9 TC 29 Z9 30 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD JUN PY 1992 VL 26 IS 6 BP 991 EP 994 DI 10.1016/0190-9622(92)70145-6 PG 4 WC Dermatology SC Dermatology GA HW817 UT WOS:A1992HW81700016 PM 1607419 ER PT J AU PERICH, MJ BUNNER, BL TIDWELL, MA WILLIAMS, DC MARA, CD CARVALHE, T AF PERICH, MJ BUNNER, BL TIDWELL, MA WILLIAMS, DC MARA, CD CARVALHE, T TI PENETRATION OF ULTRA-LOW VOLUME APPLIED INSECTICIDE INTO DWELLINGS FOR DENGUE VECTOR CONTROL SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Article ID AEDES-AEGYPTI; SANTO-DOMINGO AB Determinations on the penetration of ultra-low volume applied insecticide into dwellings was accomplished with a model house in Frederick, MD, USA, and native houses in Santo Domingo, Dominican Republic. Results from the model house tests show that aerosol droplets, with a volume median diameter of 4-mu-m, penetrated and remained suspended in low recesses of the building during the first 2 min after spraying. Similar results were found with tests in Santo Domingo, where man-made or natural obstructions were determined to be critical factors in aerosol penetration. RP PERICH, MJ (reprint author), USA,BIOMED RES & DEV LAB,FREDERICK,MD 21702, USA. NR 15 TC 8 Z9 8 U1 0 U2 1 PU AMER MOSQUITO CONTROL ASSN INC PI LAKE CHARLES PA 707-A EAST PRIEN LAKE ROAD, PO BOX 5416, LAKE CHARLES, LA 70606-5416 SN 8756-971X J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD JUN PY 1992 VL 8 IS 2 BP 137 EP 142 PG 6 WC Entomology SC Entomology GA JB810 UT WOS:A1992JB81000004 PM 1431855 ER PT J AU PAGAC, BB HARLAN, HJ DORAN, SD BROSNIHAN, MA AF PAGAC, BB HARLAN, HJ DORAN, SD BROSNIHAN, MA TI NEW STATE RECORD FOR CULISETA-IMPATIENS IN MARYLAND SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Note AB Culiseta impatiens is reported for the first time from Maryland. Collections from the southwestern border of Fort George G. Meade extend the range of this species over 400 km farther south than previous records. Multiple collections from 4 separate traps during 2 years indicate a population of Cs. impatiens is probably established in the collection area. RP PAGAC, BB (reprint author), USA,ENVIRONM HYG ACTIV NORTH,DIV ENTOMOL SCI,FT GEORGE G MEADE,MD 20755, USA. NR 4 TC 2 Z9 2 U1 0 U2 0 PU AMER MOSQUITO CONTROL ASSN INC PI LAKE CHARLES PA 707-A EAST PRIEN LAKE ROAD, PO BOX 5416, LAKE CHARLES, LA 70606-5416 SN 8756-971X J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD JUN PY 1992 VL 8 IS 2 BP 196 EP 196 PG 1 WC Entomology SC Entomology GA JB810 UT WOS:A1992JB81000017 PM 1359008 ER PT J AU PLICHTA, EJ BEHL, WK VUJIC, D CHANG, WHS SCHLEICH, DM AF PLICHTA, EJ BEHL, WK VUJIC, D CHANG, WHS SCHLEICH, DM TI THE RECHARGEABLE LIXTIS2/LIALCL4/LI1-XCOO2 SOLID-STATE CELL SO JOURNAL OF THE ELECTROCHEMICAL SOCIETY LA English DT Article ID INTERCALATION ELECTRODES; LITHIUM AB An all solid-state cell employing lithium tetrachloroaluminate (LiAlCl4) as the lithium ion conducting solid electrolyte and using lithium intercalating compounds, titanium disulfide (TiS2), and lithium cobalt (III) oxide (LiCoO2), as the electroactive materials in the "rocking chair" configuration is described. Thin films of TiS2 were prepared by chemical vapor deposition onto aluminum substrates while thin films of LiCoO2 on aluminum were prepared by organometallic decomposition and used as the negative and positive electrodes, respectively. On charge, LiCoO2 was delithiated and the lithium ions were transported through the solid electrolyte to the TiS2 electrode where they were intercalated and formed lithiated titanium disulfide (LixTiS2). On discharge, the electrode processes are reversed. The cell was operated at 100-degrees-C and exhibited an open-circuit potential of 2.1 V in the charged state. The cell showed excellent discharge characteristics at current densities up to 0.1 mA/cm2 and also showed only a slight loss of capacity over one hundred charge-discharge cycles. C1 POLYTECH INST NEW YORK,BROOKLYN,NY 11201. RP PLICHTA, EJ (reprint author), USA,ELECTR TECHNOL & DEVICES LAB,LABCOM,DIV POWER SOURCES,FT MONMOUTH,NJ 07703, USA. NR 14 TC 23 Z9 23 U1 3 U2 10 PU ELECTROCHEMICAL SOC INC PI PENNINGTON PA 10 SOUTH MAIN STREET, PENNINGTON, NJ 08534 SN 0013-4651 J9 J ELECTROCHEM SOC JI J. Electrochem. Soc. PD JUN PY 1992 VL 139 IS 6 BP 1509 EP 1513 DI 10.1149/1.2069446 PG 5 WC Electrochemistry; Materials Science, Coatings & Films SC Electrochemistry; Materials Science GA HX978 UT WOS:A1992HX97800007 ER PT J AU KIM, JM CARR, WN ZETO, RJ POLI, L AF KIM, JM CARR, WN ZETO, RJ POLI, L TI REACTIVE ION ETCHING TECHNIQUES FOR SILICON SIDEWALL ANGLE CONTROL IN MICROENGINEERING SO JOURNAL OF THE ELECTROCHEMICAL SOCIETY LA English DT Article ID DEVICES AB This paper describes reactive ion etching (RIE) techniques with silicon substrates for initial processing of semiconductor field emitter array cathodes for vacuum microelectronics. A secondary focus is process research for optical reflecting gratings for opto- and micromechanical devices. These applications each require control of the sidewall angle and apex radius. In this paper, we describe micromachining control of trenches with remainder sidewall angles varying from 15-60-degrees and resulting apex ridge radii of as small as 40 nm. A fluorine-based chemistry (CF4/O2) with oblique angles for the incident beam (tilted substrates) and overetching is used. The use of both deep UV-hardened photoresist and aluminum as RIE shadowmasks is compared. Unannealed aluminum as a shadowmask for RIE micromachining has the advantage of lower etch/sputtering rates and higher process temperature tolerance compared to photoresist in the CF4/O2 RIE system. Etch environments in the pressure range 30-80 mTorr with CF4/O2 flow rates of 20/2 sccm, RF power 100-200 W, and etch duration 30 min are described. Both tilted and untilted substrates mountings were studied. Under these conditions, the surface erosion is primarily a combination of ion milling and chemical etch mechanisms. Both P-type and N-type substrates of 100 nm diam wafers were used. Relatively sharp single- and double-ridged silicon structures were obtained using the photoresist shadowmask on untilted substrates. The photoresist shadowmask provides an advantage over Al only for the sidewall orientation theta(t) = 20-degrees where we were able to specify a condition for obtaining a smooth optically reflective surface. The more vertical sidewall angles obtainable with the unannealed Al shadowmask should permit fabrication of field emitter cone or ridge cathodes on pedestals with higher height-to-width ratios. A field cathode pedestal with a more vertical sidewall results in a higher electric field at the electron emission tip or ridge. C1 USA,ETDL,FT MONMOUTH,NJ 07703. RP KIM, JM (reprint author), NEW JERSEY INST TECHNOL,MICROELECTR RES CTR,NEWARK,NJ 07102, USA. NR 27 TC 9 Z9 9 U1 1 U2 4 PU ELECTROCHEMICAL SOC INC PI PENNINGTON PA 10 SOUTH MAIN STREET, PENNINGTON, NJ 08534 SN 0013-4651 J9 J ELECTROCHEM SOC JI J. Electrochem. Soc. PD JUN PY 1992 VL 139 IS 6 BP 1700 EP 1705 DI 10.1149/1.2069480 PG 6 WC Electrochemistry; Materials Science, Coatings & Films SC Electrochemistry; Materials Science GA HX978 UT WOS:A1992HX97800040 ER PT J AU PINNICK, RG FERNANDEZ, GL XIE, JG RUEKGAUER, T GU, J ARMSTRONG, RL AF PINNICK, RG FERNANDEZ, GL XIE, JG RUEKGAUER, T GU, J ARMSTRONG, RL TI STIMULATED RAMAN-SCATTERING AND LASING IN MICROMETER-SIZED CYLINDRICAL LIQUID JETS - TIME AND SPECTRAL DEPENDENCE SO JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICS LA English DT Article ID ELASTIC-SCATTERING; FLUORESCENCE EMISSION; RESONANCE STRUCTURE; LASER-EMISSION; DROPLETS; MICRODROPLETS; MICROSPHERES; ENHANCEMENT; WAVELENGTHS; DISTORTION AB Stimulated Raman scattering (SRS) in micrometer-sized water and carbon tetrachloride liquid cylinders irradiated with a pulsed frequency-doubled Nd:YAG laser (pulse length 8 ns, peak intensity almost-equal-to 4 GW/cm2) have been observed. As was found previously for spherical droplets, SRS is supported by natural cavity mode resonances of the cylinder. For water cylinders SRS spectra consist of quasi-periodic peaks within the spontaneous Raman band, and the separation of the peaks suggests that the dominant emission is supported by resonances of a single mode order. As many as 14 orders of Stokes shifts are observed in carbon tetrachloride cylinders. SRS is delayed (approximately 6 ns) with respect to elastic scattering and is suppressed by the addition of a small amount of absorptive material to the liquid. Measurement of SRS light scattered perpendicular to the cylinder axis shows it to have the same time and spectral dependence (1) in the region of the pump laser beam for perpendicular and nonperpendicular incidence and (2) in regions of the cylinder located at least 0.5 cm along the cylinder axis from the irradiated portion. Lasing has been observed in water cylinders doped with Rhodamine 6G dye, and spectral measurements suggest that, like SRS, lasing also is supported by resonances. C1 NEW MEXICO STATE UNIV,DEPT PHYS,LAS CRUCES,NM 88003. RP PINNICK, RG (reprint author), ATMOSPHER SCI LAB,WHITE SANDS MISSILE RANGE,NM 88002, USA. NR 38 TC 22 Z9 22 U1 0 U2 1 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0740-3224 J9 J OPT SOC AM B JI J. Opt. Soc. Am. B-Opt. Phys. PD JUN PY 1992 VL 9 IS 6 BP 865 EP & DI 10.1364/JOSAB.9.000865 PG 0 WC Optics SC Optics GA HX185 UT WOS:A1992HX18500003 ER PT J AU WESTERVELT, P HENKEL, T TROWBRIDGE, DB ORENSTEIN, J HEUSER, J GENDELMAN, HE RATNER, L AF WESTERVELT, P HENKEL, T TROWBRIDGE, DB ORENSTEIN, J HEUSER, J GENDELMAN, HE RATNER, L TI DUAL REGULATION OF SILENT AND PRODUCTIVE INFECTION IN MONOCYTES BY DISTINCT HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 DETERMINANTS SO JOURNAL OF VIROLOGY LA English DT Note ID TRANS-ACTIVATOR GENE; OPEN READING FRAME; HTLV-III; T-CELL; MONONUCLEAR PHAGOCYTES; AIDS VIRUS; REPLICATION; HIV-1; MACROPHAGES; PROTEIN AB The regulation of human immunodeficiency virus type 1 infection and replication in primary monocytes was investigated by mutagenesis of recombinant proviral clones containing an env determinant required for the infectivity of monocytes. Virus replication was assayed by determination of reverse transcriptase activity in culture fluids and by recovery of virus from monocytes following cocultivation with uninfected peripheral blood mononuclear cells. Three virus replication phenotypes were observed in monocytes: productive infection, silent infection, and no infection. Incorporation of the monocytotropic env determinant in a full-length clone incapable of infection or replication in primary monocytes (no infection) conferred the capacity for highly efficient virus replication in monocytes (productive infection). Clones with the env determinant but lacking either functional vpr or vpu genes generated lower replication levels in monocytes. Mutation of both vpr and vpu, however, resulted in nearly complete attenuation of virus replication in monocytes, despite subsequent virus recovery from infected monocytes by cocultivation with uninfected peripheral blood mononuclear cells (silent infection). These findings indicate a central role for the "accessory" genes vpu and vpr in productive human immunodeficiency virus type 1 replication in monocytes and indicate that vpu and vpr may be capable of functional complementation. C1 WASHINGTON UNIV,SCH MED,DEPT MED & MOLEC MICROBIOL,ST LOUIS,MO 63110. WALTER REED ARMY MED CTR,HENRY M JACKSON FDN ADVANCEMENT MIL MED,ROCKVILLE,MD 20850. GEORGE WASHINGTON UNIV,DEPT PATHOL,WASHINGTON,DC 20037. WASHINGTON UNIV,SCH MED,DEPT CELL BIOL,ST LOUIS,MO 63110. WALTER REED ARMY MED CTR,DEPT CELLULAR IMMUNOL,ROCKVILLE,MD 20850. FU NIAID NIH HHS [AI 24745]; PHS HHS [5T32A107172] NR 38 TC 111 Z9 111 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0022-538X J9 J VIROL JI J. Virol. PD JUN PY 1992 VL 66 IS 6 BP 3925 EP 3931 PG 7 WC Virology SC Virology GA HU599 UT WOS:A1992HU59900080 PM 1533883 ER PT J AU LAX, DS BENSTEIN, JA TOLBERT, E DWORKIN, LD AF LAX, DS BENSTEIN, JA TOLBERT, E DWORKIN, LD TI EFFECTS OF SALT RESTRICTION ON RENAL GROWTH AND GLOMERULAR INJURY IN RATS WITH REMNANT KIDNEYS SO KIDNEY INTERNATIONAL LA English DT Article ID INTERLEUKIN-1 GENE-EXPRESSION; MESANGIAL CELLS; UNINEPHRECTOMIZED SHR; HYPERTROPHY; HYPERTENSION; PROGRESSION; DISEASE; TESTOSTERONE; PROTEINURIA; SCLEROSIS AB Effects of salt restriction on renal growth and glomerular injury in rats with remnant kidneys. Male Munich-Wistar rats underwent right nephrectomy and infraction of two thirds of the left kidney. Rats were randomly assigned to ingest standard chow (REM) or a moderately salt restricted chow (LS). A third group of rats were fed the low salt diet and were injected with an androgen (LSA). Eight weeks after ablation, glomerular volume and glomerular capillary radius were markedly increased in REM. This increase was prevented by the low salt diet, however, the antihypertrophic effect of the diet was overcome by androgen. Values for glomerular volume and capillary radius were similar in LSA and REM. Morphologic studies revealed that approximately 25% of glomeruli were abnormal in REM. Much less injury was observed in salt restricted rats, however, the protective effect of the low salt diet was significantly abrogated when renal growth was stimulated in salt restricted rats by androgen. Micropuncture studies revealed that glomerular pressure was elevated in all three groups and not affected by diet or androgen. Serum cholesterol was also similar in the three groups. These findings indicate that renal and glomerular hypertrophy are correlated with the development of glomerular injury after reduction in renal mass and suggest that dietary salt restriction lessens renal damage, at least in part, by inhibiting compensatory renal growth. C1 NYU MED CTR,DEPT MED,550 1ST AVE,NEW YORK,NY 10016. TRIPLER ARMY MED CTR,DEPT MED,HONOLULU,HI 96859. FU NIDDK NIH HHS [DK 38157] NR 45 TC 76 Z9 77 U1 0 U2 0 PU BLACKWELL SCIENCE INC PI MALDEN PA 350 MAIN ST, MALDEN, MA 02148 SN 0085-2538 J9 KIDNEY INT JI Kidney Int. PD JUN PY 1992 VL 41 IS 6 BP 1527 EP 1534 DI 10.1038/ki.1992.222 PG 8 WC Urology & Nephrology SC Urology & Nephrology GA HW904 UT WOS:A1992HW90400006 PM 1501409 ER PT J AU LIU, CT GUO, ZM AF LIU, CT GUO, ZM TI CARDIOVASCULAR-RESPONSES TO INTRACEREBROVENTRICULAR INFUSION OF ARTIFICIAL CEREBROSPINAL-FLUID IN ANESTHETIZED STRAIN-13 GUINEA-PIGS SO LABORATORY ANIMAL SCIENCE LA English DT Article ID INCREASED INTRACRANIAL-PRESSURE; RATS; HYPERTENSION; DOG AB The cardiovascular effects of constant intracerebroventricular infusion in anesthetized strain 13 guinea pigs were studied. Bilateral cerebroventricles of the animals were catheterized stereotaxically with two 20-gauge blunt needles, penetrating 5 to 6 mm into the skull. Baseline cerebroventricular pressure values were 1.3 +/- 0.6 mmHg. After artificial cerebrospinal fluid was infused into the left ventricle at 0.5 ml/h, left cerebroventricular pressure increased to 8.1 +/- 1.6 mmHg (P < 0.01), while right cerebroventricular pressure reached 5.6 +/- 2.2 mmHg within 20 minutes. No significant changes in mean blood pressure or heart rate were observed. When intracerebroventricular infusion rate increased to 5.0 ml/h, cerebrospinal fluid pressures of eft and right cerebroventricles increased to 40.0 +/- 4.8 and 38.4 +/- 4.7 mmHg within 10 minutes from baseline values of 1.5 +/- 0.5 and 1.7 +/- 0.7 mmHg, respectively. Simultaneously, mean blood pressure and heart rate increased from 72 +/- 4 to 101 +/- 9 mmHg and from 195 +/- 11 to 218 +/- 17 beats/min, respectively. However, 30 to 50 minutes later, m an blood pressure, heart rate, and cerebrospinal fluid pressure decreased abruptly, and two of four animals died. We suggest that this technique with a low infusion rate (< 0.5 ml/h) can be used to deliver certain drugs into the brain ventricles directly without producing undesirable effects on blood pressure or heart rate. C1 USA,MED RES INST INFECT DIS,DEPT CLIN & EXPTL PHYSIOL,DIV DIS ASSESSMENT,FREDERICK,MD 21702. NR 21 TC 1 Z9 1 U1 0 U2 0 PU AMER ASSOC LABORATORY ANIMAL SCIENCE PI CORDOVA PA 70 TIMBERCREEK DR, SUITE 5, CORDOVA, TN 38018 SN 0023-6764 J9 LAB ANIM SCI JI Lab. Anim. Sci. PD JUN PY 1992 VL 42 IS 3 BP 275 EP 279 PG 5 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA JA579 UT WOS:A1992JA57900010 PM 1320159 ER PT J AU GRABENSTEIN, JD HARTZEMA, AG GUESS, HA JOHNSTON, WP RITTENHOUSE, BE AF GRABENSTEIN, JD HARTZEMA, AG GUESS, HA JOHNSTON, WP RITTENHOUSE, BE TI COMMUNITY PHARMACISTS AS IMMUNIZATION ADVOCATES - COST-EFFECTIVENESS OF A CUE TO INFLUENZA VACCINATION SO MEDICAL CARE LA English DT Article DE PHARMACISTS; IMMUNIZATION; COST-EFFECTIVENESS MODEL; INFLUENZA; VACCINE; MEDICARE ID DIFFERENT POSTCARD CUES; PROSPECTIVE TRIAL; UNITED-STATES; REMINDERS; EPIDEMICS; PREVENTION; MORTALITY; DISEASE; IMPACT; INFECTIONS AB To assess the cost-effectiveness of a cue to influenza vaccination provided by community pharmacists, a decision tree was constructed of the consequences of implementing a pharmacy-based vaccine-advocacy program, based on experience gained in an experiment involving three community pharmacies in Durham County, North Carolina. The model used morbidity and mortality assumptions derived from the infectious-disease literature and cost assumptions based on 1990-91 Medicare Part A and Part B reimbursement costs. This analysis suggests that if Medicare reimbursed pharmacists for advising 100,000 patients at risk to accept influenza vaccine through vaccine-advocacy messages, for an apparent expenditure of $110,000, the increased rate of influenza vaccinations would avert 139 hospitalizations and 63 deaths, and actually yield Medicare a net savings of $280,588. These calculations probably underestimate the benefit to society of a pharmacy-based vaccine-advocacy program, because only direct costs to the single government agency were computed and no cost was attributed to death or lost earnings. C1 UNIV N CAROLINA,SCH PHARM & PUBL HLTH,CHAPEL HILL,NC 27514. WALTER REED ARMY MED CTR,DEPT PHARM,WASHINGTON,DC 20307. NR 57 TC 33 Z9 33 U1 1 U2 4 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0025-7079 J9 MED CARE JI Med. Care PD JUN PY 1992 VL 30 IS 6 BP 503 EP 513 DI 10.1097/00005650-199206000-00004 PG 11 WC Health Care Sciences & Services; Health Policy & Services; Public, Environmental & Occupational Health SC Health Care Sciences & Services; Public, Environmental & Occupational Health GA HX948 UT WOS:A1992HX94800004 PM 1593916 ER PT J AU SAWKA, MN GREENLEAF, JE AF SAWKA, MN GREENLEAF, JE TI CURRENT CONCEPTS CONCERNING THIRST, DEHYDRATION, AND FLUID REPLACEMENT - OVERVIEW SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Article DE DEHYDRATION; CARBOHYDRATE ELECTROLYTE SOLUTIONS; FLUID REPLACEMENT; FLUID IMBALANCE; REPLACEMENT FLUIDS; HEAT INJURY AB For healthy endurance athletes, two potentially life-threatening medical emergencies are dehydration-mediated heat injuries and hyponatremia. Likewise, dehydration reduces exercise performance via thermoregulatory and cardiovascular impairment as well as electrolyte imbalances. Authors of this symposium integrate new research findings with established concepts concerning the development of dehydration (body water deficit), the physiological and medical consequences of fluid imbalance, and fluid (volume and composition) replacement strategies that minimize the risk of medical emergencies and optimize exercise performance. The following papers provide the readers with an appreciation of the historical development of current concepts and offer an informed opinion concerning fluid replacement strategies for a variety of work performance athletic events. C1 NASA,AMES RES CTR,MOFFETT FIELD,CA 94035. RP SAWKA, MN (reprint author), USA,ENVIRONM MED RES INST,NATICK,MA 01760, USA. NR 8 TC 15 Z9 17 U1 0 U2 9 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD JUN PY 1992 VL 24 IS 6 BP 643 EP 644 PG 2 WC Sport Sciences SC Sport Sciences GA HX581 UT WOS:A1992HX58100004 PM 1602936 ER PT J AU SAWKA, MN AF SAWKA, MN TI PHYSIOLOGICAL CONSEQUENCES OF HYPOHYDRATION - EXERCISE PERFORMANCE AND THERMOREGULATION SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Article DE BLOOD VOLUME; CORE TEMPERATURE; DEHYDRATION; HEAT STRESS; HYPEROSMOLALITY; HYPOVOLEMIA; SKIN BLOOD FLOW; SWEATING; TONICITY ID DIURETIC-INDUCED DEHYDRATION; INDUCED LIMB VASODILATION; VASCULAR FLUID SHIFTS; HEAT-STRESS; PLASMA-VOLUME; TEMPERATURE REGULATION; BLOOD-VOLUME; BODY-FLUIDS; PROLONGED EXERCISE; MUSCLE GLYCOGEN AB During exercise in the heat, sweat output often exceeds water intake, which results in a body water deficit or hypohydration. This water deficit occurs from both the intracellular and extracellular fluid compartments, and causes a hypertonic-hypovolemia of the blood. Aerobic exercise tasks are likely to be adversely affected by hypohydration; and the warmer the environment the greater the potential for performance decrements. Hypohydration causes greater heat storage and reduces one's ability to tolerate heat strain. The greater heat storage is mediated by reduced sweating rate (evaporative heat loss) and reduced skin blood flow (dry heat loss) for a given core temperature. Reductions of sweating rate and skin blood flow are most tightly coupled to blood hypertonicity and hypovolemia, respectively. In addition, hypovolemia and the displacement of blood to the skin make it difficult to maintain central venous pressure and thus an adequate cardiac output to simultaneously support metabolism and thermoregulation during exercise-heat stress. RP SAWKA, MN (reprint author), USA,ENVIRONM MED RES INST,NATICK,MA 01760, USA. NR 128 TC 216 Z9 226 U1 4 U2 81 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD JUN PY 1992 VL 24 IS 6 BP 657 EP 670 PG 14 WC Sport Sciences SC Sport Sciences GA HX581 UT WOS:A1992HX58100006 PM 1602938 ER PT J AU SINGH, A MOSES, FM DEUSTER, PA AF SINGH, A MOSES, FM DEUSTER, PA TI CHRONIC MULTIVITAMIN-MINERAL SUPPLEMENTATION DOES NOT ENHANCE PHYSICAL PERFORMANCE SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Article DE VITAMIN SUPPLEMENTS; MINERAL SUPPLEMENTS; EXERCISE; MUSCLE STRENGTH; MAXIMAL OXYGEN CONSUMPTION ID ENDURANCE; COMPLAINTS; EXERCISE; VITAMIN AB The effects on physical performance of 90 d of supplementation with a high potency multivitamin-mineral supplement were studied in a double-blind, placebo-controlled design. Twenty-two healthy, physically active men were randomly assigned to a supplement (S) or placebo (P) group; both groups had similar physical characteristics. Performance was assessed from maximal aerobic capacity, endurance capacity, and isokinetic tests. Supplementation did not affect maximal aerobic capacity: pre and after approximately 12 wk of supplementation values for maximal oxygen consumption (48.5 +/- 1.3 vs 46.2 +/- 1.1 ml.kg-1.min-1), maximal heart rate (186 +/- 2 vs 187 +/- 2 beats.min-1) or treadmill time (19.96 +/- 0.48 vs 19.99 +/- 0.37 min) did not differ in the S group; similar findings were noted in the P group. Performance during the 90-min endurance run, as assessed from heart rates, rectal temperatures, and plasma glucose, lactate and adrenocorticotropin values, was not affected by treatment. Similarly, muscle strength and endurance were not affected. Thus, supplementation did not affect physical performance in well-nourished men who maintained their physical activity. C1 WALTER REED ARMY MED CTR,GASTROENTEROL SERV,WASHINGTON,DC 20307. RP SINGH, A (reprint author), UNIFORMED SERV UNIV HLTH SCI,DEPT MIL MED,BETHESDA,MD 20814, USA. RI Deuster, Patricia/G-3838-2015 OI Deuster, Patricia/0000-0002-7895-0888 NR 22 TC 26 Z9 26 U1 0 U2 1 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD JUN PY 1992 VL 24 IS 6 BP 726 EP 732 PG 7 WC Sport Sciences SC Sport Sciences GA HX581 UT WOS:A1992HX58100015 PM 1602947 ER PT J AU BABBITT, RW KOSCICA, TE DRACH, WC AF BABBITT, RW KOSCICA, TE DRACH, WC TI PLANAR MICROWAVE ELECTROOPTIC PHASE SHIFTERS SO MICROWAVE JOURNAL LA English DT Article ID DC BLOCK; MICROSTRIP AB Design considerations for a planar, microwave electro-optic phase shifter in microstrip are discussed. Materials, packaging, voltage bias connection and isolation, and impedance matching are included. Results on a prototype phase shifter using BaxSr1-xTiO3 material are presented. RP BABBITT, RW (reprint author), USA,LABCOM,ELECTR TECHNOL & DEVICES LAB,FT MONMOUTH,NJ 07703, USA. NR 13 TC 102 Z9 104 U1 0 U2 0 PU HORIZON HOUSE-MICROWAVE PI NORWOOD PA 685 CANTON ST, NORWOOD, MA 02062 SN 0192-6225 J9 MICROWAVE J JI Microw. J. PD JUN PY 1992 VL 35 IS 6 BP 63 EP & PG 0 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA JK669 UT WOS:A1992JK66900002 ER PT J AU BORCH, FL AF BORCH, FL TI SOLDIERS OF THE SUN - HARRIES,M, HARRIES,S SO MILITARY LAW REVIEW LA English DT Book Review C1 USA,JUDGE ADVOCATE GEN SCH,DIV CRIMINAL LAW,WASHINGTON,DC 20310. RP BORCH, FL (reprint author), USA,JUDGE ADVOCATE GEN CORPS,WASHINGTON,DC 20310, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD SUM PY 1992 VL 137 BP 241 EP 244 PG 4 WC Law SC Government & Law GA JU573 UT WOS:A1992JU57300006 ER PT J AU WILLIAMS, LH AF WILLIAMS, LH TI EFFECTIVE NEGOTIATION - A GUIDE TO DIALOG MANAGEMENT AND CONTROL - RAMUNDO,BA SO MILITARY LAW REVIEW LA English DT Book Review RP WILLIAMS, LH (reprint author), USA,WASHINGTON,DC 20310, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD SUM PY 1992 VL 137 BP 244 EP 245 PG 2 WC Law SC Government & Law GA JU573 UT WOS:A1992JU57300007 ER PT J AU CALDWELL, JA AF CALDWELL, JA TI A BRIEF SURVEY OF CHEMICAL DEFENSE, CREW REST, AND HEAT-STRESS PHYSICAL-TRAINING ISSUES RELATED TO OPERATION DESERT STORM SO MILITARY MEDICINE LA English DT Article AB A brief questionnaire was administered to 148 soldiers, over two-thirds of whom were aviators, at the conclusion of Desert Storm. Questions were asked about chemical defense, work/rest schedules, an aspect of pharmacological support. and heat stress/physical training during Operations Desert Shield and Desert Storm. Follow-up face-to-face interviews also were conducted with some respondents. Some of the most noteworthy findings concerned (1) training issues and side effects related to pyridostigmine bromide, (2) problems with chemical defense clothing, (3) suggestions for improving crew rest, and (4) facts about the ways in which heat-related difficulties were minimized. RP CALDWELL, JA (reprint author), USA,AEROMED RES LAB,SGRD,UAB CS,BOX 577,FT RUCKER,AL 36362, USA. NR 0 TC 9 Z9 9 U1 0 U2 2 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUN PY 1992 VL 157 IS 6 BP 275 EP 281 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA HY168 UT WOS:A1992HY16800005 PM 1620391 ER PT J AU RAMCHARAN, B AF RAMCHARAN, B TI ANATOMY OF A CONTRACT SO MILITARY MEDICINE LA English DT Article AB Medical planners are constantly searching for new initiatives to solve thc health care provider shortage. One of thc most widely used methods to meet this need is contracting. This article focuses on the essential steps necessary to develop a successful contract using the Direct Health Care Provider Program. It also outlines the differences between personal services and non-personal services contracts. RP RAMCHARAN, B (reprint author), USA,MEDDAC,DIV CLIN SUPPORT,FT STEWART,GA 31314, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUN PY 1992 VL 157 IS 6 BP 300 EP 301 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA HY168 UT WOS:A1992HY16800012 PM 1620398 ER PT J AU CHISICK, MC GUERIN, RD WILLIAMS, TR AF CHISICK, MC GUERIN, RD WILLIAMS, TR TI REACTION OF ARMY FAMILIES WITH GRADE SCHOOL-CHILDREN TO THE ACTIVE DUTY DEPENDENTS DENTAL INSURANCE PLAN SO MILITARY MEDICINE LA English DT Article AB In March-May 1988, we collected data on enrollment of 1,445 Army families with grade school children in the Active Duty Dependents Dental Insurance Plan at two Army posts. We also surveyed their reactions to the plan., Results show that, although nearly two-thirds of families are enrolled in the plan, most consider the plan a loss of benefits and coverage inadequate. Queues and limited services at military clinics are primary reasons for joining; poor coverage of the dental insurance plan is the main reason for not. A majority of families are willing to pay more for expanded coverage. RP CHISICK, MC (reprint author), USA,HLTH CARE STUDIES & CLIN INVEST ACT,DIV DENT STUDIES,FT SAM HOUSTON,TX 78234, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUN PY 1992 VL 157 IS 6 BP 307 EP 310 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA HY168 UT WOS:A1992HY16800014 PM 1620400 ER PT J AU ROTHBERG, JM KOSHES, RJ AF ROTHBERG, JM KOSHES, RJ TI YOUTH ATTEMPTED-SUICIDE SO MILITARY MEDICINE LA English DT Letter RP ROTHBERG, JM (reprint author), WALTER REED ARMY MED CTR,DEPT MIL PSYCHIAT,WASHINGTON,DC 20307, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUN PY 1992 VL 157 IS 6 BP A6 EP A6 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA HY168 UT WOS:A1992HY16800004 PM 1620390 ER PT J AU LETTERIE, GS CHOW, GE AF LETTERIE, GS CHOW, GE TI EFFECT OF MISSED PILLS ON ORAL-CONTRACEPTIVE EFFECTIVENESS SO OBSTETRICS AND GYNECOLOGY LA English DT Article ID OVARIAN AB Objective: The purpose of this study was to determine whether missing pills in an oral contraceptive (OC) cycle resulted in folliculogenesis and eventual ovulation. Methods: Fifteen women selected from a population requesting tubal reanastomosis were randomized into three groups and issued pill packs missing four consecutive pills in specific sequences, as follows: group I, days 1-4; group II, days 3-6; and group III, days 6-9. Serum was drawn for assay of LH, FSH, estradiol (E2), and progesterone, and serial ovarian ultrasound examinations were done to study follicular development throughout the cycle at 4-day intervals. Results: No subject ovulated, as suggested by serum progesterone concentrations (not exceeding 0.63 ng/mL for any woman) and ultrasound assessment of follicular development (no follicular diameter exceeding 13 mm). The highest (mean +/- standard deviation) serum concentrations of LH and FSH in any group (13.25 +/- 18.71 and 14.40 +/- 7.71 mIU/mL, respectively) and of E2 (44.35 +/- 26.79 pg/mL) were observed during or immediately after the pill-free interval. Ovarian ultrasound examinations suggested suppressed folliculogenesis in all groups. No functional ovarian cysts were detected. Conclusions: Oral contraceptives exerted a similar degree of pituitary and ovarian suppression even when the subjects missed four pills at varying times in a cycle. The anovulatory effect persisted when the OC pills were reinstituted and taken reliably after an interval of noncompliance. C1 TRIPLER ARMY MED CTR,DEPT OBSTET & GYNECOL,REPROD ENDOCRINOL SERV,HONOLULU,HI 96859. NR 14 TC 32 Z9 32 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0029-7844 J9 OBSTET GYNECOL JI Obstet. Gynecol. PD JUN PY 1992 VL 79 IS 6 BP 979 EP 982 PG 4 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA HV394 UT WOS:A1992HV39400018 PM 1579326 ER PT J AU VARR, WF COOK, RA AF VARR, WF COOK, RA TI SHOTGUN EYE INJURIES - OCULAR RISK AND EYE PROTECTION EFFICACY SO OPHTHALMOLOGY LA English DT Article ID SAFETY GLASSES; POLYCARBONATE AB Background: Little is known about the efficacy of shotgun eye protection. Shotguns can easily propel pellets with enough energy to penetrate the human eye, and a large percentage of shotgun eye injuries occur during shotgun sports such as hunting, trap, skeet, and sporting clays. Many of these injuries are preventable with proper eye protection. Although it is known that polycarbonate is the best lens material for shotgun eye protection, there has been no research that addresses the vision protective system design and its influence on eye protection. Methods: A field study was performed during which shotshells were fired at 1:1 scale photographs of human faces to determine the risk of ocular trauma. The protective efficacy of three types of polycarbonate protective eye wear (standard industrial safety glasses with snap-on side shields, wrap-around racket sport glasses, and three-piece glasses with integral side shields) was tested by firing shotshells at them at various distances. Both frontal and side protection was evaluated. Results. Results showed that the eye is at a high risk (55% to 100%) of being hit with shot pellets at ranges of 15 to 40 yards. It also was determined that the protective eye wear will give good frontal eye protection from shotgun pellets but integral side shields and a headband are necessary to obtain adequate side protection. Conclusion: These findings, coupled with the poor visual prognosis of ocular shotgun injuries, indicate that polycarbonate protective eye wear with integral side shields and headbands should be worn by all involved with shotgun sports. C1 USA,CTR AEROMED,FT RUCKER,AL 36360. NR 15 TC 9 Z9 9 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0161-6420 J9 OPHTHALMOLOGY JI Ophthalmology PD JUN PY 1992 VL 99 IS 6 BP 867 EP 872 PG 6 WC Ophthalmology SC Ophthalmology GA HX373 UT WOS:A1992HX37300012 PM 1630775 ER PT J AU BURROWS, EP AF BURROWS, EP TI DIFFERENTIATION AMONG ISOMERIC POLYFUNCTIONAL NITROAROMATICS BY DIMETHYL ETHER CHEMICAL IONIZATION MASS-SPECTROMETRY IN A CONVENTIONAL ION-SOURCE SO ORGANIC MASS SPECTROMETRY LA English DT Letter RP BURROWS, EP (reprint author), USA,BIOMED RES & DEV LAB,FREDERICK,MD 21702, USA. NR 5 TC 11 Z9 11 U1 0 U2 0 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0030-493X J9 ORG MASS SPECTROM JI Org. Mass Spectrom. PD JUN PY 1992 VL 27 IS 6 BP 763 EP 764 DI 10.1002/oms.1210270623 PG 2 WC Chemistry, Organic; Spectroscopy SC Chemistry; Spectroscopy GA HZ332 UT WOS:A1992HZ33200022 ER PT J AU HENRICKSON, M WEISSE, ME AF HENRICKSON, M WEISSE, ME TI TUBERCULOUS BRAIN-ABSCESS IN A 3-YEAR-OLD SOUTH-PACIFIC ISLANDER SO PEDIATRIC INFECTIOUS DISEASE JOURNAL LA English DT Article DE TUBERCULOUS BRAIN ABSCESS; TUBERCULOSIS; TUBERCULOMA ID CHILDREN C1 TRIPLER ARMY MED CTR,DEPT PEDIAT,HONOLULU,HI 96859. WILLIAM BEAUMONT ARMY MED CTR,DEPT PEDIAT,EL PASO,TX 79920. RP HENRICKSON, M (reprint author), CHILDRENS HOSP MED CTR,DIV RHEUMATOL,PARILION BLDG,ELLAND & BETHESDA AVES,CINCINNATI,OH 45229, USA. NR 34 TC 7 Z9 7 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0891-3668 J9 PEDIATR INFECT DIS J JI Pediatr. Infect. Dis. J. PD JUN PY 1992 VL 11 IS 6 BP 488 EP 491 DI 10.1097/00006454-199206000-00012 PG 4 WC Immunology; Infectious Diseases; Pediatrics SC Immunology; Infectious Diseases; Pediatrics GA HY530 UT WOS:A1992HY53000012 PM 1608687 ER PT J AU SKOOG, SJ RUSHTON, HG AF SKOOG, SJ RUSHTON, HG TI SUMMARY OF THE ANNUAL-MEETING OF THE SECTION ON UROLOGY, AMERICAN-ACADEMY-OF-PEDIATRICS SO PEDIATRICS LA English DT Editorial Material C1 GEORGE WASHINGTON UNIV,WASHINGTON,DC 20052. CHILDRENS HOSP,NATL MED CTR,NATL MED CTR,DEPT PEDIAT NEUROL,WASHINGTON,DC 20010. RP SKOOG, SJ (reprint author), WALTER REED ARMY MED CTR,WASHINGTON,DC 20307, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD, ELK GROVE VILLAGE, IL 60007-1098 SN 0031-4005 J9 PEDIATRICS JI Pediatrics PD JUN PY 1992 VL 89 IS 6 BP 1099 EP 1104 PN 1 PG 6 WC Pediatrics SC Pediatrics GA HX376 UT WOS:A1992HX37600023 ER PT J AU BURKE, DS AF BURKE, DS TI HUMAN HIV VACCINE TRIALS - DOES ANTIBODY-DEPENDENT ENHANCEMENT POSE A GENUINE RISK SO PERSPECTIVES IN BIOLOGY AND MEDICINE LA English DT Article ID IMMUNODEFICIENCY-VIRUS TYPE-1; FELINE INFECTIOUS PERITONITIS; DENGUE HEMORRHAGIC-FEVER; MEDIATED ENHANCEMENT; HUMAN-MONOCYTES; FC-RECEPTORS; RABIES VIRUS; EARLY DEATH; CELL-LINE; GLYCOPROTEIN C1 WALTER REED ARMY MED CTR,DIV RETROVIROL,ROCKVILLE,MD 20850. RP BURKE, DS (reprint author), WALTER REED ARMY MED CTR,WALTER REED INST RES,DEPT ACAD AFFAIRS,WASHINGTON,DC 20307, USA. OI /0000-0002-5704-8094 NR 54 TC 50 Z9 50 U1 0 U2 1 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0031-5982 J9 PERSPECT BIOL MED JI Perspect. Biol. Med. PD SUM PY 1992 VL 35 IS 4 BP 511 EP 530 PG 20 WC History & Philosophy Of Science; Medicine, Research & Experimental SC History & Philosophy of Science; Research & Experimental Medicine GA JG701 UT WOS:A1992JG70100004 PM 1513680 ER PT J AU KANT, GJ BAUMAN, RA ANDERSON, SM MOUGEY, EH AF KANT, GJ BAUMAN, RA ANDERSON, SM MOUGEY, EH TI EFFECTS OF CONTROLLABLE VS UNCONTROLLABLE CHRONIC STRESS ON STRESS-RESPONSIVE PLASMA HORMONES SO PHYSIOLOGY & BEHAVIOR LA English DT Note DE STRESS; ACTH; CORTICOSTERONE; PROLACTIN ID PITUITARY CYCLIC-AMP; CORTICOSTERONE; PROLACTIN; HABITUATION; DEPRESSION; BINDING; ACTH AB We have previously reported effects of chronic stress on circadian rhythms of temperature, eating, and locomotor activity. These studies were conducted using an around-the-clock signalled intermittent footshock paradigm in which some rats have control over shock termination while other rats are yoked to the rats with control. Although this paradigm is stressful, as suggested by decreases in food intake and disrupted circadian rhythms. rats tolerate the paradigm well, continuing to eat, drink, gain weight, and groom. In the present studies, rats were sacrificed following 3 or 14 days of stress, and plasma was collected for hormonal assays. After 3 days of stress, plasma corticosterone and prolactin levels were elevated in both stress groups compared to controls, yoked rats had higher levels of corticosterone than rats in the group with control over shock termination, while prolactin levels in both stressed groups were similar. ACTH levels were similar in stressed and control rats. After 14 days of stress, ACTH and corticosterone levels in both stress groups were similar to control levels. Prolactin levels were elevated in the yoked experimental group compared to levels in control or controllable stress groups. These data support previous studies suggesting that control over stressors attenuates the effects of stress on physiology and demonstrate that two hormones with diverse biological effects are elevated by chronic stress. RP KANT, GJ (reprint author), WALTER REED ARMY MED CTR,DEPT MED NEUROSCI,WASHINGTON,DC 20307, USA. NR 30 TC 56 Z9 56 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0031-9384 J9 PHYSIOL BEHAV JI Physiol. Behav. PD JUN PY 1992 VL 51 IS 6 BP 1285 EP 1288 DI 10.1016/0031-9384(92)90323-T PG 4 WC Psychology, Biological; Behavioral Sciences SC Psychology; Behavioral Sciences GA JA635 UT WOS:A1992JA63500031 PM 1322544 ER PT J AU ENGELHARDT, CF AF ENGELHARDT, CF TI NATIONAL GUARD CANT HACK IT SO POLICY REVIEW LA English DT Letter RP ENGELHARDT, CF (reprint author), USA,ARLINGTON,VA 22209, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU HERITAGE FOUNDATION PI WASHINGTON PA 214 MASSACHUSETTS AVE NE, WASHINGTON, DC 20002 SN 0146-5945 J9 POLICY REV JI Policy Rev. PD SUM PY 1992 VL 61 BP 94 EP 95 PG 2 WC Political Science SC Government & Law GA JB502 UT WOS:A1992JB50200019 ER PT J AU CVETKOVICH, TA LAZAR, E BLUMBERG, BM SAITO, Y ESKIN, TA REICHMAN, R BARAM, DA DELCERRO, C GENDELMAN, HE DELCERRO, M EPSTEIN, LG AF CVETKOVICH, TA LAZAR, E BLUMBERG, BM SAITO, Y ESKIN, TA REICHMAN, R BARAM, DA DELCERRO, C GENDELMAN, HE DELCERRO, M EPSTEIN, LG TI HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 INFECTION OF NEURAL XENOGRAFTS SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE AIDS; CENTRAL NERVOUS SYSTEM; FETAL BRAIN; MONOCYTE MACROPHAGE ID AIDS ENCEPHALOPATHY; III INFECTION; LAV/HTLV-III; CHILDREN; BRAIN; HIV-1; PATHOGENESIS; MACROPHAGE; DISEASE; FETUS AB Human immunodeficiency virus type 1 (HIV-1) infection is highly specific for its human host. To study HIV-1 infection of the human nervous system, we have established a small animal model in which second-trimester (11 to 17.5 weeks) human fetal brain or neural retina is transplanted to the anterior chamber of the eye of immunosuppressed adult rats. The human xenografts vascularized, formed a blood-brain barrier, and differentiated, forming neurons and glia. The xenografts were infected with cell-free HIV-1 or with HIV-1-infected human monocytes. Analysis by polymerase chain reaction revealed HIV-1 sequences in DNA from xenograft tissue exposed to HIV-1 virions, and in situ hybridization demonstrated HIV-1 mRNA localized in macrophages and multinucleated giant cells. Pathological damage was observed only in neural xenografts containing HIV-1-infected human monocytes, supporting the hypothesis that these cells mediate neurotoxicity. This small animal model allows the study of direct and indirect effects of HIV-1 infection on developing human fetal neural tissues, and it should prove useful in evaluating antiviral therapies, which must ultimately target HIV-1 infection of the brain. C1 WALTER REED ARMY MED CTR,HENRY M JACKSON FDN ADV MIL,ROCKVILLE,MD 20850. UNIV ROCHESTER,DEPT PEDIAT,ROCHESTER,NY 14642. UNIV ROCHESTER,DEPT MICROBIOL & IMMUNOL,ROCHESTER,NY 14642. UNIV ROCHESTER,DEPT PATHOL,ROCHESTER,NY 14642. UNIV ROCHESTER,DEPT NEUROBIOL & ANAT,ROCHESTER,NY 14642. UNIV ROCHESTER,DEPT MED,ROCHESTER,NY 14642. UNIV ROCHESTER,DEPT OBSTET & GYNECOL,ROCHESTER,NY 14642. WALTER REED ARMY MED CTR,DEPT CELLULAR IMMUNOL,HIV IMMUNOPATHOGENESIS PROGRAM,ROCKVILLE,MD 20850. RP CVETKOVICH, TA (reprint author), UNIV ROCHESTER,DEPT NEUROL,ROCHESTER,NY 14642, USA. FU NEI NIH HHS [EY09217]; NIAID NIH HHS [AI32305]; NINDS NIH HHS [NS28754] NR 40 TC 29 Z9 29 U1 0 U2 0 PU NATL ACAD PRESS PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD JUN 1 PY 1992 VL 89 IS 11 BP 5162 EP 5166 DI 10.1073/pnas.89.11.5162 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA HX168 UT WOS:A1992HX16800079 PM 1594627 ER PT J AU HURLBERT, DF APT, C AF HURLBERT, DF APT, C TI THE MALEVOLENT PERSONALITY-DISORDER SO PSYCHOLOGICAL REPORTS LA English DT Article ID POLARIZATION AB The identification of any new psychopathology or syndrome has been based on numerous clinical enquiries and theoretical discussions and has assumed an important place in the literature of psychology and psychiatry. Using two case descriptions and the subject described in a recent book, this report presents a theoretical discussion of an unusual personality organization, referred to as the malevolent personality disorder. Differential diagnosis, theorizing about pathogenesis, clarification of salient psychodynamics, and treatment considerations are explored. C1 USA, WASHINGTON, DC 20310 USA. UNIV TEXAS SAN ANTONIO, SAN ANTONIO, TX 78285 USA. NR 23 TC 0 Z9 0 U1 1 U2 3 PU AMMONS SCIENTIFIC, LTD PI MISSOULA PA PO BOX 9229, MISSOULA, MT 59807-9229 USA SN 0033-2941 J9 PSYCHOL REP JI Psychol. Rep. PD JUN PY 1992 VL 70 IS 3 BP 979 EP 991 DI 10.2466/PR0.70.3.979-991 PN 1 PG 13 WC Psychology, Multidisciplinary SC Psychology GA HW439 UT WOS:A1992HW43900053 PM 1620791 ER PT J AU KOSHES, RJ AF KOSHES, RJ TI USE OF AMITRIPTYLINE IN A PATIENT WITH TINNITUS SO PSYCHOSOMATICS LA English DT Article C1 KENNER ARMY COMMUNITY HOSP,FT LEE,VA. UNIFORMED SERV UNIV HLTH SCI,F EDWARD HEBERT SCH MED,BETHESDA,MD 20814. NR 5 TC 4 Z9 4 U1 0 U2 0 PU AMER PSYCHIATRIC ASSOCIATION PI WASHINGTON PA 1400 K ST NW, WASHINGTON, DC 20005 SN 0033-3182 J9 PSYCHOSOMATICS JI Psychosomatics PD SUM PY 1992 VL 33 IS 3 BP 341 EP 343 PG 3 WC Psychiatry; Psychology SC Psychiatry; Psychology GA JB243 UT WOS:A1992JB24300015 PM 1410210 ER PT J AU STOKES, CE AF STOKES, CE TI VISITORS VIEWS SO PUBLIC HISTORIAN LA English DT Art Exhibit Review RP STOKES, CE (reprint author), USA,FT GORDON,GA 30905, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU UNIV CALIF PRESS PI BERKELEY PA JOURNALS DEPT 2120 BERKELEY WAY, BERKELEY, CA 94720 SN 0272-3433 J9 PUBL HISTORIAN JI Public Hist. PD SUM PY 1992 VL 14 IS 3 BP 169 EP 170 PG 2 WC History SC History GA JN469 UT WOS:A1992JN46900040 ER PT J AU FAMINI, GR ASHMAN, WP MICKIEWICZ, AP WILSON, LY AF FAMINI, GR ASHMAN, WP MICKIEWICZ, AP WILSON, LY TI USING THEORETICAL DESCRIPTORS IN QUANTITATIVE STRUCTURE-ACTIVITY-RELATIONSHIPS - OPIATE RECEPTOR ACTIVITY BY FENTANYL-LIKE COMPOUNDS SO QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIPS LA English DT Article DE TLSER; LSER; OPIATE RECEPTOR ACTIVITY; MOLECULAR ORBITAL THEORY; MNDO ID SOLVATION ENERGY RELATIONSHIPS; LOCAL EMPIRICAL RULES; ENZYME-INHIBITORS; FUNDAMENTAL LAWS; PI-STAR; CHEMOMETRICIANS; CHEMISTRY; ALPHA; BETA; QSAR AB The number of applications of computational techniques to medicinal chemistry is growing rapidly. Quantitative Structure-Activity Relationships (QSAR) have been used very successfully to correlate structural features to biological activities. A type of QSAR, Linear Solvation Energy Relationships (LSER) has been used to correlate a large number and wide variety of biological properties. Famini and Wilson have developed a theoretical extension of the LSER, called the TLSER, that incorporates only computationally derived descriptors. We have applied the TLSER methodology to a series of fentanyl-like compounds that exhibit activity at the opiate receptor. TLSER correlations of the entire data set, as well as specific subsets are considered. C1 LA SIERRA UNIV,DEPT CHEM,RIVERSIDE,CA 92515. RP FAMINI, GR (reprint author), USA,CTR DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010, USA. NR 27 TC 24 Z9 24 U1 1 U2 5 PU VCH PUBLISHERS INC PI DEERFIELD BEACH PA 303 NW 12TH AVE, DEERFIELD BEACH, FL 33442-1788 SN 0931-8771 J9 QUANT STRUCT-ACT REL JI Quant. Struct.-Act. Relat. PD JUN PY 1992 VL 11 IS 2 BP 162 EP 170 DI 10.1002/qsar.19920110206 PG 9 WC Chemistry, Medicinal; Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA JB072 UT WOS:A1992JB07200005 ER PT J AU SMITH, PB SNYDER, AP AF SMITH, PB SNYDER, AP TI ELECTROSPRAY IONIZATION TANDEM MASS-SPECTROMETRY OF MIXTURES - DECONVOLUTION BY PARENT-ION SCANS SO RAPID COMMUNICATIONS IN MASS SPECTROMETRY LA English DT Article ID PROTEINS; SPECTRA AB Electrospray ionization (ESI) mass spectra of equine myoglobin and a mixture of bovine insulin, melittin and bovine growth hormone releasing factor (GHRF) were obtained on a tandem quadrupole mass spectrometer. The parent-ion mass spectrum of m/z 171 for equine myoglobin contained all of the multiply charged molecular ions present in the conventional ESI mass spectrum. Similar results were obtained with parent-ion scans of selected ions for the insulin, melittin and GHRF mixture. This technique was able to differentiate between the multiply charged molecular ions produced from each of the three components in the mixture. C1 USA,CTR DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010. RP SMITH, PB (reprint author), GEO CENTERS INC,GUNPOWDER BRANCH,POB 68,ABERDEEN PROVING GROUND,MD 21010, USA. NR 13 TC 0 Z9 0 U1 0 U2 1 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0951-4198 J9 RAPID COMMUN MASS SP JI Rapid Commun. Mass Spectrom. PD JUN PY 1992 VL 6 IS 6 BP 373 EP 375 DI 10.1002/rcm.1290060604 PG 3 WC Chemistry, Analytical; Spectroscopy SC Chemistry; Spectroscopy GA HY212 UT WOS:A1992HY21200003 ER PT J AU POPE, KO SHEFFNER, EJ LINTHICUM, KJ BAILEY, CL LOGAN, TM KASISCHKE, ES BIRNEY, K NJOGU, AR ROBERTS, CR AF POPE, KO SHEFFNER, EJ LINTHICUM, KJ BAILEY, CL LOGAN, TM KASISCHKE, ES BIRNEY, K NJOGU, AR ROBERTS, CR TI IDENTIFICATION OF CENTRAL KENYAN RIFT-VALLEY FEVER VIRUS VECTOR HABITATS WITH LANDSAT TM AND EVALUATION OF THEIR FLOODING STATUS WITH AIRBORNE IMAGING RADAR SO REMOTE SENSING OF ENVIRONMENT LA English DT Article ID POLARIZATION SIGNATURE; FORESTED AREAS; EGYPT 1977-78; SCATTERING AB Rift Valley Fever (RVF) is a mosquito-borne virus that affects livestock and humans in Africa. Landsat Thematic Mapper (TM) data are shown to be effective in identifying dambos, intermittently flooded areas that are potential mosquito breeding sites, in an area north of Nairobi, Kenya. Positive results were obtained from a limited test of flood detection in dambos with airborne high resolution L, C, and X band multipolarization synthetic aperture radar (SAR) imagery. L and C bands were effective in detecting flooded dambos, but LHH was by far the best channel for discrimination (p < 0.01) between flooded and nonflooded sites in both sedge and short grass environments. This study demonstrates the feasibility of a combined passive and active remote sensing program for monitoring the location and condition of RVF vector habitats, thus making future control of the disease more promising. C1 NASA,AMES RES CTR,TGS TECHNOL INC,MS 2424,MOFFETT FIELD,CA 94035. GEO ECO ARC RES,LA CANADA,CA. USA,MED RES INST INFECT DIS,FREDERICK,MD 21701. ENVIRONM RES INST MICHIGAN,ANN ARBOR,MI 48107. USN,CTR AIR DEV,WARMINSTER,PA 18974. KENYA TRYPANOSOMIASIS RES INST,KIKUYU,KENYA. USA,MED RES UNIT,NAIROBI,KENYA. NR 26 TC 59 Z9 65 U1 0 U2 4 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0034-4257 J9 REMOTE SENS ENVIRON JI Remote Sens. Environ. PD JUN PY 1992 VL 40 IS 3 BP 185 EP 196 DI 10.1016/0034-4257(92)90002-2 PG 12 WC Environmental Sciences; Remote Sensing; Imaging Science & Photographic Technology SC Environmental Sciences & Ecology; Remote Sensing; Imaging Science & Photographic Technology GA HW982 UT WOS:A1992HW98200002 ER PT J AU BEAUCHAMP, JJ MCCARTHY, JF ROSENBLATT, DH SHUGART, LR AF BEAUCHAMP, JJ MCCARTHY, JF ROSENBLATT, DH SHUGART, LR TI STATISTICAL DESIGN FOR SAMPLING AND ANALYSIS OF ANIMAL POPULATIONS FOR CHEMICAL CONTAMINATION SO RISK ANALYSIS LA English DT Article DE BODY BURDENS; ANALYSIS DECISION; NONDETECTABLE VALUES ID WATER-QUALITY DATA; DETECTION LIMIT AB A strategy for sampling of animal tissues and a statistical approach for analyzing data on body burdens of a parent chemical and its metabolites is presented such that the data may be evaluated in relation to the detection limit(s) of the analytical techniques used and the criterion levels established for acceptable tissue concentrations. C1 OAK RIDGE NATL LAB,DIV ENVIRONM SCI,POB 2008,OAK RIDGE,TN 37831. OAK RIDGE NATL LAB,DIV ENGN PHYS & MATH,OAK RIDGE,TN 37831. USA,BIOMED RES & DEV LAB,DIV HLTH EFFECTS RES,FT DETRICK,MD 21701. NR 13 TC 2 Z9 2 U1 0 U2 0 PU PLENUM PUBL CORP PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 SN 0272-4332 J9 RISK ANAL JI Risk Anal. PD JUN PY 1992 VL 12 IS 2 BP 233 EP 238 DI 10.1111/j.1539-6924.1992.tb00670.x PG 6 WC Public, Environmental & Occupational Health; Mathematics, Interdisciplinary Applications; Social Sciences, Mathematical Methods SC Public, Environmental & Occupational Health; Mathematics; Mathematical Methods In Social Sciences GA JD213 UT WOS:A1992JD21300007 ER PT J AU ROBLES, HA SMIRNIOTOPOULOS, JG FIGUEROA, RE AF ROBLES, HA SMIRNIOTOPOULOS, JG FIGUEROA, RE TI UNDERSTANDING THE RADIOLOGY OF INTRACRANIAL PRIMITIVE NEUROECTODERMAL TUMORS FROM A PATHOLOGICAL PERSPECTIVE - A REVIEW SO SEMINARS IN ULTRASOUND CT AND MRI LA English DT Article RP ROBLES, HA (reprint author), BROOKE ARMY MED CTR,DEPT RADIOL,FT SAM HOUSTON,TX 78234, USA. RI Smirniotopoulos, James/D-3726-2011 NR 0 TC 19 Z9 19 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0887-2171 J9 SEMIN ULTRASOUND CT JI Semin. Ultrasound CT MRI PD JUN PY 1992 VL 13 IS 3 BP 170 EP 181 PG 12 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA HZ372 UT WOS:A1992HZ37200003 PM 1322685 ER PT J AU DAULA, TV SMITH, DA AF DAULA, TV SMITH, DA TI ARE HIGH-QUALITY PERSONNEL COST-EFFECTIVE - THE ROLE OF EQUIPMENT COSTS SO SOCIAL SCIENCE QUARTERLY LA English DT Article AB As measured by entry test scores and high school graduation status, high-quality soldiers are more productive but also cost more to recruit. Studies to determine the cost-effective level of accession quality have typically focused only on personnel-related measures of productivity and costs. Using armor forces as an example, the authors show that ignoring the equipment cost implications of changing the level of quality understates the cost-effectiveness of investing in high-quality personnel. RP DAULA, TV (reprint author), US MIL ACAD,DEPT SOCIAL SCI,W POINT,NY 10996, USA. NR 10 TC 0 Z9 0 U1 0 U2 0 PU UNIV TEXAS PRESS PI AUSTIN PA BOX 7819, AUSTIN, TX 78713-7819 SN 0038-4941 J9 SOC SCI QUART JI Soc. Sci. Q. PD JUN PY 1992 VL 73 IS 2 BP 266 EP 275 PG 10 WC Social Sciences, Interdisciplinary SC Social Sciences - Other Topics GA JC975 UT WOS:A1992JC97500005 ER PT J AU WATTENDORF, JM AF WATTENDORF, JM TI THE AMERICAN SOLDIER IN A PREWAR DESERT ENVIRONMENT - OBSERVATIONS FROM DESERT SHIELD SO SOCIAL SCIENCE QUARTERLY LA English DT Article AB In-depth interviews with U.S. Army soldiers serving in Saudi Arabia prior to the onset of hostilities between the coalition forces and Iraq (Operation Desert Shield) provided the basis for sociological observations concerning prewar attitudes and opinions held by U.S. ground forces during a time of great uncertainty and ambiguity. Observations range from concrete sociological and psychological consequences of living and working conditions to more abstract perceptions concerning the legitimation of war and the nature of victory for these soldiers. RP WATTENDORF, JM (reprint author), US MIL ACAD,DEPT BEHAV SCI & LEADERSHIP,W POINT,NY 10996, USA. NR 17 TC 2 Z9 2 U1 0 U2 0 PU UNIV TEXAS PRESS PI AUSTIN PA BOX 7819, AUSTIN, TX 78713-7819 SN 0038-4941 J9 SOC SCI QUART JI Soc. Sci. Q. PD JUN PY 1992 VL 73 IS 2 BP 276 EP 295 PG 20 WC Social Sciences, Interdisciplinary SC Social Sciences - Other Topics GA JC975 UT WOS:A1992JC97500006 ER PT J AU GOUGH, TJ AF GOUGH, TJ TI ISOLATION AND PROFESSIONALIZATION OF THE ARMY OFFICER CORPS - A POST-REVISIONIST VIEW OF THE-SOLDIER-AND-THE-STATE SO SOCIAL SCIENCE QUARTERLY LA English DT Article AB Despite revisionist critiques of The Soldier and the State, Huntington was essentially correct in perceiving an estrangement between army officers and civilians, especially businessmen, in the late nineteenth and early twentieth centuries. Yet he implausibly portrayed technical officers as merely impediments to professionalism championed by line officers. The technical officers, who perceived themselves professionally threatened by both line officers and aggressive businessmen, were the necessary bridge between the army and the commercial world in the new era of industrial-based war. The study of officer professionalization should refocus to encompass their difficult and essential role. RP GOUGH, TJ (reprint author), USA,CTR MIL HIST,WASHINGTON,DC 20374, USA. NR 55 TC 2 Z9 2 U1 0 U2 0 PU UNIV TEXAS PRESS PI AUSTIN PA BOX 7819, AUSTIN, TX 78713-7819 SN 0038-4941 J9 SOC SCI QUART JI Soc. Sci. Q. PD JUN PY 1992 VL 73 IS 2 BP 420 EP 436 PG 17 WC Social Sciences, Interdisciplinary SC Social Sciences - Other Topics GA JC975 UT WOS:A1992JC97500015 ER PT J AU ALVING, BM BARR, CF JOHANSEN, LE TANG, DB AF ALVING, BM BARR, CF JOHANSEN, LE TANG, DB TI COMPARISON BETWEEN A ONE-POINT DILUTE PHOSPHOLIPID APTT AND THE DILUTE RUSSELL VIPER VENOM TIME FOR VERIFICATION OF LUPUS ANTICOAGULANTS SO THROMBOSIS AND HAEMOSTASIS LA English DT Article ID ANTICARDIOLIPIN ANTIBODIES; ANTIPHOSPHOLIPID ANTIBODIES; COAGULATION; DIAGNOSIS; SPECIFICITY; INHIBITORS; TESTS AB In the present study, the dilute Russell viper venom time (RVVT) and the dilute phospholipid activated partial thromboplastin time (PL-APTT), which are two assays used for the verification of lupus anticoagulants (LA), were modified to increase standardization. The modified assays were then compared with respect to sensitivity and specificity in detecting LA in plasmas from 72 patients with a prolonged APTT. Modifications included utilizing a single dilution of phospholipid that was either bovine brain thromboplastin (Thrombofax) or liposomes comprised of phosphatidylcholine/phosphatidylserine, and expressing the results as a ratio of the clotting times of the mixture of patient and normal plasma/clotting time of normal plasma. In the RVVT, the correlation coefficient between assay results for liposomes and Thrombofax was 0.88 and in the PL-APTT, the correlation was 0.68. A positive test for LA was defined as a ratio of greater-than-or-equal-to 1.3 for the PL-APTT with liposomes and greater-than-or-equal-to 1.2 for the PL-APTT with Thrombofax and the RVVT with Thrombofax or liposomes. Regardless of the phospholipid source in the test system, the PL-APTT demonstrated higher sensitivity and the RVVT showed greater specificity in detecting patient plasmas that contained antiphospholipid antibodies. C1 WALTER REED ARMY MED CTR,DIV BIOMETR,WASHINGTON,DC 20307. RP ALVING, BM (reprint author), WALTER REED ARMY MED CTR,DEPT HEMATOL,WASHINGTON,DC 20307, USA. NR 33 TC 21 Z9 21 U1 0 U2 0 PU F K SCHATTAUER VERLAG GMBH PI STUTTGART PA P O BOX 10 45 45, LENZHALDE 3, D-70040 STUTTGART, GERMANY SN 0340-6245 J9 THROMB HAEMOSTASIS JI Thromb. Haemost. PD JUN 1 PY 1992 VL 67 IS 6 BP 672 EP 678 PG 7 WC Hematology; Peripheral Vascular Disease SC Hematology; Cardiovascular System & Cardiology GA HZ356 UT WOS:A1992HZ35600016 PM 1509408 ER PT J AU MAXWELL, DM AF MAXWELL, DM TI THE SPECIFICITY OF CARBOXYLESTERASE PROTECTION AGAINST THE TOXICITY OF ORGANOPHOSPHORUS COMPOUNDS SO TOXICOLOGY AND APPLIED PHARMACOLOGY LA English DT Article ID INHIBITION; SOMAN; ACETYLCHOLINESTERASE; SERUM; LIVER; RATS RP MAXWELL, DM (reprint author), USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010, USA. NR 36 TC 147 Z9 151 U1 3 U2 16 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0041-008X J9 TOXICOL APPL PHARM JI Toxicol. Appl. Pharmacol. PD JUN PY 1992 VL 114 IS 2 BP 306 EP 312 DI 10.1016/0041-008X(92)90082-4 PG 7 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA HY258 UT WOS:A1992HY25800017 PM 1609424 ER PT J AU POTASH, MJ ZEIRA, M HUANG, ZB PEARCE, TE EDEN, E GENDELMAN, HE VOLSKY, DJ AF POTASH, MJ ZEIRA, M HUANG, ZB PEARCE, TE EDEN, E GENDELMAN, HE VOLSKY, DJ TI VIRUS-CELL MEMBRANE-FUSION DOES NOT PREDICT EFFICIENT INFECTION OF ALVEOLAR MACROPHAGES BY HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 (HIV-1) SO VIROLOGY LA English DT Note ID RECOMBINANT SOLUBLE CD4; MONONUCLEAR PHAGOCYTES; T-CELLS; ENTRY; EXPRESSION; MONOCYTES; ANTIBODY; TROPISM C1 ST LUKES ROOSEVELT HOSP, MOLEC VIROL LAB, NEW YORK, NY 10025 USA. ST LUKES ROOSEVELT HOSP, DIV PULM DIS, NEW YORK, NY 10025 USA. COLUMBIA UNIV, COLL PHYS & SURG, NEW YORK, NY 10019 USA. HENRY M JACKSON FDN ADVANCEMENT MIL MED, ROCKVILLE, MD 20850 USA. WALTER REED ARMY MED CTR, DEPT CELLULAR IMMUNOL, HIV IMMUNOPATHOGENESIS PROGRAM, ROCKVILLE, MD 20850 USA. FU NCI NIH HHS [CA-37465]; NHLBI NIH HHS [R01 HL043628, HL-43628] NR 33 TC 32 Z9 32 U1 0 U2 0 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0042-6822 J9 VIROLOGY JI Virology PD JUN PY 1992 VL 188 IS 2 BP 864 EP 868 DI 10.1016/0042-6822(92)90543-X PG 5 WC Virology SC Virology GA HU511 UT WOS:A1992HU51100049 PM 1585653 ER PT J AU IACONOCONNORS, LC SCHMALJOHN, CS AF IACONOCONNORS, LC SCHMALJOHN, CS TI CLONING AND SEQUENCE-ANALYSIS OF THE GENES ENCODING THE NONSTRUCTURAL PROTEINS OF LANGAT VIRUS AND COMPARATIVE-ANALYSIS WITH OTHER FLAVIVIRUSES SO VIROLOGY LA English DT Note ID BORNE ENCEPHALITIS-VIRUS; AMINO-ACID-SEQUENCE; NUCLEOTIDE-SEQUENCE; CROSS-NEUTRALIZATION; GENOME; EXPRESSION RP IACONOCONNORS, LC (reprint author), USA,MED RES INST INFECT DIS,DIV VIROL,FT DETRICK,FREDERICK,MD 21702, USA. NR 19 TC 23 Z9 24 U1 0 U2 0 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0042-6822 J9 VIROLOGY JI Virology PD JUN PY 1992 VL 188 IS 2 BP 875 EP 880 DI 10.1016/0042-6822(92)90545-Z PG 6 WC Virology SC Virology GA HU511 UT WOS:A1992HU51100051 PM 1316684 ER PT J AU ANTIC, D KANG, CY SPIK, K SCHMALJOHN, C VAPALAHTI, O VAHERI, A AF ANTIC, D KANG, CY SPIK, K SCHMALJOHN, C VAPALAHTI, O VAHERI, A TI COMPARISON OF THE DEDUCED GENE-PRODUCTS OF THE L-GENOME, M-GENOME AND S-GENOME SEGMENTS OF HANTAVIRUSES SO VIRUS RESEARCH LA English DT Article; Proceedings Paper CT 8TH INTERNATIONAL CONF ON NEGATIVE STRAND VIRUSES CY SEP 15-20, 1991 CL CHARLESTON, SC DE HANTAVIRUS; AMINO ACID SEQUENCE; HUMAN ID KOREAN HEMORRHAGIC-FEVER; NUCLEOTIDE-SEQUENCE ANALYSIS; PROSPECT-HILL VIRUS; HANTAAN VIRUS; ETIOLOGIC AGENT; CODING STRATEGY; RENAL SYNDROME; UNITED-STATES; RNA AB The amino acid sequences deduced from all currently available nucleotide sequences of hantaviruses are compared. Comparisons of three large (L), eight medium (M) and five small (S) genome segments are included. A consensus sequence is provided, allowing easy identification of conserved and unique gene regions. The viruses included in this report represent four serologically distinct hantaviruses which are capable of causing severe, moderate, mild or no human disease. C1 UNIV OTTAWA,FAC MED,DEPT MICROBIOL & IMMUNOL,OTTAWA K1H 8M5,ONTARIO,CANADA. USA,MED RES INST INFECT DIS,FT DETRICK,MD 21702. UNIV HELSINKI,DEPT VIROL,SF-00290 HELSINKI 29,FINLAND. NR 27 TC 45 Z9 50 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0168-1702 J9 VIRUS RES JI Virus Res. PD JUN PY 1992 VL 24 IS 1 BP 35 EP 46 DI 10.1016/0168-1702(92)90029-9 PG 12 WC Virology SC Virology GA HZ836 UT WOS:A1992HZ83600003 PM 1626424 ER PT J AU KIM, BJ GEE, CS AF KIM, BJ GEE, CS TI HAZARDOUS-WASTE TREATMENT TECHNOLOGIES SO WATER ENVIRONMENT RESEARCH LA English DT Review ID CREOSOTE-CONTAMINATED MATERIALS; BIOLOGICAL TREATMENT PROCESSES; CEMENT-BASED STABILIZATION; BENCH-SCALE EVALUATION; PHASE BIOREMEDIATION; SITE DEMONSTRATION; SUPERFUND SITE; OIL-SPILL; REMEDIATION; BIODEGRADATION RP KIM, BJ (reprint author), USA,CONSTRUCT ENGN RES LABS,POB 9005,CHAMPAIGN,IL 61826, USA. NR 205 TC 2 Z9 2 U1 0 U2 3 PU WATER ENVIRONMENT FEDERATION PI ALEXANDRIA PA 601 WYTHE ST, ALEXANDRIA, VA 22314-1994 SN 1061-4303 J9 WATER ENVIRON RES JI Water Environ. Res. PD JUN PY 1992 VL 64 IS 4 BP 469 EP 479 PG 11 WC Engineering, Environmental; Environmental Sciences; Limnology; Water Resources SC Engineering; Environmental Sciences & Ecology; Marine & Freshwater Biology; Water Resources GA JF570 UT WOS:A1992JF57000028 ER PT J AU VENNERSTROM, JL ELLIS, WY AGER, AL ANDERSEN, SL GERENA, L MILHOUS, WK AF VENNERSTROM, JL ELLIS, WY AGER, AL ANDERSEN, SL GERENA, L MILHOUS, WK TI BISQUINOLINES .1. N,N-BIS(7-CHLOROQUINOLIN-4-YL)ALKANEDIAMINES WITH POTENTIAL AGAINST CHLOROQUINE-RESISTANT MALARIA SO JOURNAL OF MEDICINAL CHEMISTRY LA English DT Article ID QUINOLINE-CONTAINING ANTIMALARIALS; PLASMODIUM-FALCIPARUM INVITRO; BIFUNCTIONAL INTERCALATORS; 4-AMINOQUINOLINES; MECHANISMS; MEFLOQUINE; REVERSAL; STRAINS; BERGHEI AB On the basis of observations that several bisquinolines such as piperaquine possess notable activity against chloroquine-resistant malaria, 13 N,N-bis-(7-chloroquinolin-4-yl)alkanediamines were synthesized and screened against Plasmodium falciparum in vitro and Plasmodium berghei in vivo. Twelve of the thirteen bisquinolines had a significantly lower resistance index than did chloroquine; the resistance index was apparently unrelated to either in vitro or in vivo activity. Except for two compounds, there was a reasonable correlation between in vitro and in vivo activities. Seven of the thirteen bisquinolines had IC50's of less than 6 nM against both chloroquine-sensitive (D-6) and -resistant (W-2) clones of P. falciparum and were curative against P. berghei at doses of 640 mg/kg. In contrast to chloroquine, these bisquinolines did not show any toxic deaths at curative dose levels. Four bisquinolines, however, caused skin lesions at the site of injection. Maximum activity was seen in bisquinolines with a connecting bridge of two carbon atoms where decreased conformational mobility seemed to increase activity. Bisquinoline 3 ((+/-)-trans-N1,N2-bis(7-chloroquinolin-4-yl)cyclohexane-1,2-diamine was not only the most potent bisquinoline in vitro, but was clearly unique in its in vivo activity-80% and 100% cure rates were achieved at doses of 160 and 320 mg/kg, respectively. In summary, these preliminary results support the premise that bisquinolines may be useful agents against chloroquine-resistant malaria. C1 UNIV MIAMI,SCH MED,DEPT MICROBIOL & IMMUNOL,MIAMI,FL 33177. WALTER REED ARMY MED CTR,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307. RP VENNERSTROM, JL (reprint author), UNIV NEBRASKA,MED CTR,COLL PHARM,600 S 42ND ST,OMAHA,NE 68198, USA. FU NIAID NIH HHS [1 R15 AI28012-01] NR 54 TC 99 Z9 99 U1 1 U2 3 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0022-2623 J9 J MED CHEM JI J. Med. Chem. PD MAY 29 PY 1992 VL 35 IS 11 BP 2129 EP 2134 DI 10.1021/jm00089a025 PG 6 WC Chemistry, Medicinal SC Pharmacology & Pharmacy GA HX265 UT WOS:A1992HX26500025 PM 1597862 ER PT J AU JAYASURIYA, K AF JAYASURIYA, K TI A COMPUTATIONAL INVESTIGATION OF THE EFFECTS OF SUBSTITUENTS ON THE CP GROUP SO JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM LA English DT Article ID H-C=C-C=P; MICROWAVE-SPECTRUM; PHOSPHORUS-COMPOUNDS; 1-PHOSPHABUT-3-ENE-1-YNE; PHOSPHABUTADIYNE; PHOSPHAALKYNES; CH2=CHC=P AB Recently, there has been a rapid development in the preparation of multiple bond systems with heavy main group elements phosphorus and carbon. Ab initio self-consistent field (SCF) molecular orbital calculations were performed at the 4-31G* level to determine the effect of substituent groups -F, -CF3, H-C=C-, CH2=CH-, and phenyl, on the C=P triple bond. A characteristic feature of phospha-alkynes is the weak sensitivity of the C=P bond length to the substituent at the carbon atom. The molecular electrostatic potential analysis clearly reflects the strengths of the electronegativities of these substituent groups and their ability to attract the polarizable charge from the C=P triple bond. The C=P group deactivates the phenyl ring towards electrophilic attack. RP JAYASURIYA, K (reprint author), USA, CTR RES DEV & ENGN, CEOCTR CORP, BLDG 3028, PICATINNY ARSENAL, NJ 07806 USA. NR 15 TC 6 Z9 6 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-1280 J9 J MOL STRUC-THEOCHEM JI Theochem-J. Mol. Struct. PD MAY 25 PY 1992 VL 257 IS 3-4 BP 405 EP 415 DI 10.1016/0166-1280(92)85052-M PG 11 WC Chemistry, Physical SC Chemistry GA HZ663 UT WOS:A1992HZ66300011 ER PT J AU ZHAO, JH BURKE, T LARSON, D WEINER, M CHIN, A BALLINGALL, JM YU, TH AF ZHAO, JH BURKE, T LARSON, D WEINER, M CHIN, A BALLINGALL, JM YU, TH TI USING REVERSE DYNAMIC IV CHARACTERISTICS OF ALGAAS/GAAS OPTOTHYRISTOR FOR PULSED POWER-SWITCHING APPLICATIONS SO ELECTRONICS LETTERS LA English DT Article DE OPTOTHYRISTORS; SEMICONDUCTOR DEVICES; OPTOELECTRONIC DEVICES AB The reverse dynamic current-voltage (I-V) characteristics of a high performance MBE grown AlGaAs/GaAs based heterostructure optothyristor have been studied for high power pulsed switching applications. Switched current and dissipated energy per switching as a function of the blocking voltage are presented. Possible reverse switching mechanisms are also discussed in terms of the novel device structure. C1 USA,LABCOM,ETD LAB,FT MONMOUTH,NJ 07703. GE,ELECTR LAB,SYRACUSE,NY 13221. RP ZHAO, JH (reprint author), RUTGERS STATE UNIV,DEPT ELECT & COMP ENGN,POB 909,PISCATAWAY,NJ 08855, USA. NR 4 TC 1 Z9 1 U1 0 U2 0 PU IEE-INST ELEC ENG PI HERTFORD PA MICHAEL FARADAY HOUSE SIX HILLS WAY STEVENAGE, HERTFORD, ENGLAND SG1 2AY SN 0013-5194 J9 ELECTRON LETT JI Electron. Lett. PD MAY 21 PY 1992 VL 28 IS 11 BP 977 EP 979 DI 10.1049/el:19920621 PG 3 WC Engineering, Electrical & Electronic SC Engineering GA HW541 UT WOS:A1992HW54100004 ER PT J AU MOUL, JW MCLEOD, DG AF MOUL, JW MCLEOD, DG TI MELANOMAS THAT DEFY CLINICAL RECOGNITION SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Letter RP MOUL, JW (reprint author), WALTER REED ARMY MED CTR,WASHINGTON,DC 20307, USA. NR 2 TC 0 Z9 0 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD MAY 20 PY 1992 VL 267 IS 19 BP 2605 EP 2605 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA HT823 UT WOS:A1992HT82300021 PM 1637408 ER PT J AU WHITE, WL MUMMA, JV TOMASOVIC, JJ AF WHITE, WL MUMMA, JV TOMASOVIC, JJ TI CONGENITAL OCULOMOTOR NERVE PALSY, CEREBELLAR HYPOPLASIA, AND FACIAL CAPILLARY HEMANGIOMA SO AMERICAN JOURNAL OF OPHTHALMOLOGY LA English DT Article AB We saw two infants with the unusual combination of oculomotor nerve palsy, facial capillary hemangioma, cerebellar hypoplasia, and apparent gaze palsy. Systematic imaging of children with congenital oculomotor nerve palsy may lead to the recognition of more associated neurologic abnormalities that are not clinically apparent, as was the case in our patients. C1 BROOKE ARMY MED CTR,OPHTHALMOL SERV,FT SAM HOUSTON,TX 78234. UNIV TEXAS,HLTH SCI CTR,DEPT OPHTHALMOL,SAN ANTONIO,TX 78284. UNIV TEXAS,HLTH SCI CTR,DEPT PEDIAT,SAN ANTONIO,TX 78284. NR 10 TC 18 Z9 18 U1 0 U2 0 PU OPHTHALMIC PUBL CO PI CHICAGO PA 77 WEST WACKER DR, STE 660, CHICAGO, IL 60601 SN 0002-9394 J9 AM J OPHTHALMOL JI Am. J. Ophthalmol. PD MAY 15 PY 1992 VL 113 IS 5 BP 497 EP 500 PG 4 WC Ophthalmology SC Ophthalmology GA HR541 UT WOS:A1992HR54100002 PM 1575222 ER PT J AU KOH, G AF KOH, G TI DIELECTRIC-CONSTANT OF ICE AT 26.5-40-GHZ SO JOURNAL OF APPLIED PHYSICS LA English DT Article AB The complex dielectric constant, epsilon = epsilon' + i-epsilon", of ice at 26.5-40 GHz was determined using free-space measurement technique. A network analyzer-based system was used to measure the phase velocity and attenuation of a synthesized pulse propagating in bubble-free ice which was grown from distilled de-ionized water. Based on the phase velocity measurement, epsilon' was determined to be 3.155 +/- 0.005 and virtually independent of frequency. The loss factor in ice was observed to be frequency dependent so that epsilon" increased from approximately 0.002 at the lower frequencies to 0.004 at the higher frequencies. No temperature dependence of epsilon' and epsilon" was observed at ice temperatures of - 2.5 and - 15-degrees-C. RP KOH, G (reprint author), USA,COLD REG RES & ENGN LAB,HANOVER,NH 03755, USA. NR 7 TC 11 Z9 11 U1 0 U2 1 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD MAY 15 PY 1992 VL 71 IS 10 BP 5119 EP 5122 DI 10.1063/1.350616 PG 4 WC Physics, Applied SC Physics GA HV471 UT WOS:A1992HV47100070 ER PT J AU MEISEL, LV JOHNSON, M COTE, PJ AF MEISEL, LV JOHNSON, M COTE, PJ TI BOX-COUNTING MULTIFRACTAL ANALYSIS SO PHYSICAL REVIEW A LA English DT Article ID FRACTAL DIMENSIONS; ALGORITHM AB Two box-counting algorithms for the determination of generalized fractal dimensions are described. Results of application of the algorithms to Euclidean curves, quadric islands, Koch symmetric and asymmetric triadic snowflakes, and split snowflake halls introduced by Mandelbrot [Fractal Geometry of Nature (Freeman, New York, 1983)] are described. Comparison to analytic results for the model curves is provided and the effectiveness of the algorithms is discussed. RP MEISEL, LV (reprint author), BENET LABS,CTR CLOSE COMBAT ARMAMENT,CTR RES DEV & ENGN,WATERVLIET,NY 12189, USA. NR 9 TC 32 Z9 34 U1 2 U2 4 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1050-2947 J9 PHYS REV A JI Phys. Rev. A PD MAY 15 PY 1992 VL 45 IS 10 BP 6989 EP 6996 DI 10.1103/PhysRevA.45.6989 PG 8 WC Optics; Physics, Atomic, Molecular & Chemical SC Optics; Physics GA HV267 UT WOS:A1992HV26700012 ER PT J AU BUDE, J HESS, K IAFRATE, GJ AF BUDE, J HESS, K IAFRATE, GJ TI IMPACT IONIZATION IN SEMICONDUCTORS - EFFECTS OF HIGH ELECTRIC-FIELDS AND HIGH SCATTERING RATES SO PHYSICAL REVIEW B LA English DT Article ID QUANTUM TRANSPORT; BLOCH ELECTRONS; STATE AB We present a theory of impact ionization in semiconductors that expands an earlier theory of Kane and includes the effects of high electric fields and high scattering rates on the electron-electron collision process. We show that their combined effect, i.e., the intracollisional field effect and collision broadening, leads to a softening of the threshold energy for impact ionization and a marked increase in the anisotropy of the ionization rate with respect to the direction of the electric field. C1 USA, RES OFF, RES TRIANGLE PK, NC 27709 USA. RP BUDE, J (reprint author), UNIV ILLINOIS, BECKMAN INST ADV SCI & TECHNOL, URBANA, IL 61801 USA. NR 17 TC 75 Z9 75 U1 3 U2 8 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1098-0121 J9 PHYS REV B JI Phys. Rev. B PD MAY 15 PY 1992 VL 45 IS 19 BP 10958 EP 10964 DI 10.1103/PhysRevB.45.10958 PG 7 WC Physics, Condensed Matter SC Physics GA HU799 UT WOS:A1992HU79900014 ER PT J AU ZHOU, WM SMITH, DD SHEN, H PAMULAPATI, J DUTTA, M CHIN, A BALLINGALL, J AF ZHOU, WM SMITH, DD SHEN, H PAMULAPATI, J DUTTA, M CHIN, A BALLINGALL, J TI COMPARISON OF (111)-GROWN AND (001)-GROWN GAAS-ALXGA1-XAS QUANTUM-WELLS BY MAGNETOREFLECTANCE SO PHYSICAL REVIEW B LA English DT Note ID CYCLOTRON-RESONANCE; GAAS; HETEROSTRUCTURES; STATES; HEAVY; HOLE; BAND; MAGNETOEXCITONS; DISCONTINUITIES; CARRIERS AB Magnetoreflectance studies on GaAs/AlxGa1-xAs quantum wells grown on (111) and (001) substrates have been performed in magnetic fields from 0 to 9 T at 4.2 K. Excitonic transitions of 1s, 2s, 3s, . . . states are observed and identified for the transitions from the first heavy-hole subband to the first electron subband and from the first light-hole subband to the first electron subband in the well. From the diamagnetic shifts, we have determined the reduced effective masses, mu(perpendicular-to), and the binding energies for excitons in the well using several different methods. A comparison of the reduced masses of the excitons in the (111) and (001) samples determined experimentally gives a ratio of mu-111 perpendicular-to/mu-001 perpendicular-to = 0.91. We have also attempted to deduce the heavy-hole and light-hole effective masses perpendicular and parallel to the [111] axis, and the band parameters. C1 GE,SYRACUSE,NY 13221. GEOCENTERS INC,LAKE HOPATCONG,NJ 07849. RP ZHOU, WM (reprint author), USA,ETDL,FT MONMOUTH,NJ 07703, USA. NR 24 TC 7 Z9 7 U1 0 U2 0 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0163-1829 J9 PHYS REV B JI Phys. Rev. B PD MAY 15 PY 1992 VL 45 IS 20 BP 12156 EP 12159 DI 10.1103/PhysRevB.45.12156 PG 4 WC Physics, Condensed Matter SC Physics GA HV747 UT WOS:A1992HV74700092 ER PT J AU LESHO, EP AF LESHO, EP TI METASTATIC RENAL-CELL CARCINOMA PRESENTING AS A BREAST MASS SO POSTGRADUATE MEDICINE LA English DT Article ID HYPERNEPHROMA AB Metastasis of primary renal cell carcinoma to the breast, as in the patient described here, is rare. However, this case illustrates the importance of a high index of suspicion, further diagnostic evaluation based on results of routine tests, and use of appropriate imaging techniques in the workup of a patient with breast cancer. RP LESHO, EP (reprint author), USA,DIV INFANTRY 6,TROOP MED CLIN,BLDG 604,FT RICHARDSON,AK 99505, USA. NR 3 TC 8 Z9 8 U1 0 U2 0 PU MCGRAW HILL HEALTHCARE PUBLICATIONS PI MINNEAPOLIS PA 4530 WEST 77TH ST, MINNEAPOLIS, MN 55435-5000 SN 0032-5481 J9 POSTGRAD MED JI Postgrad. Med. PD MAY 15 PY 1992 VL 91 IS 7 BP 145 EP 146 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA HY270 UT WOS:A1992HY27000017 PM 1589363 ER PT J AU RICAURTE, GA MCCANN, UD AF RICAURTE, GA MCCANN, UD TI NEUROTOXIC AMPHETAMINE ANALOGS - EFFECTS IN MONKEYS AND IMPLICATIONS FOR HUMANS SO ANNALS OF THE NEW YORK ACADEMY OF SCIENCES LA English DT Article ID BRAIN-SEROTONIN NEURONS; TYROSINE-HYDROXYLASE ACTIVITY; DOPAMINE NERVE-TERMINALS; ORALLY-ADMINISTERED MDMA; LONG-LASTING DEPLETION; RAT-BRAIN; PARA-CHLOROAMPHETAMINE; STRIATAL DOPAMINE; CEREBROSPINAL-FLUID; CAUDATE-NUCLEUS C1 WALTER REED ARMY MED CTR, DEPT BEHAV BIOL, WASHINGTON, DC 20307 USA. RP RICAURTE, GA (reprint author), JOHNS HOPKINS UNIV, FRANCIS SCOTT KEY MED CTR, SCH MED, DEPT NEUROL, BALTIMORE, MD 21224 USA. NR 84 TC 4 Z9 4 U1 0 U2 0 PU NEW YORK ACAD SCIENCES PI NEW YORK PA 2 E 63RD ST, NEW YORK, NY 10021 USA SN 0077-8923 J9 ANN NY ACAD SCI JI Ann.NY Acad.Sci. PD MAY 11 PY 1992 VL 648 BP 371 EP 382 PG 12 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA JM216 UT WOS:A1992JM21600071 ER PT J AU SHEN, H DUTTA, M CHANG, W MOERKIRK, R KIM, DM CHUNG, KW RUDEN, PP NATHAN, MI STROSCIO, MA AF SHEN, H DUTTA, M CHANG, W MOERKIRK, R KIM, DM CHUNG, KW RUDEN, PP NATHAN, MI STROSCIO, MA TI DIRECT MEASUREMENT OF PIEZOELECTRIC FIELD IN A [111]B GROWN INGAAS/GAAS HETEROSTRUCTURE BY FRANZ-KELDYSH OSCILLATIONS SO APPLIED PHYSICS LETTERS LA English DT Article ID STRAINED-LAYER SUPERLATTICES; GAAS DEPLETION REGION; SURFACE FERMI LEVEL; ELECTRIC-FIELD; PHOTOREFLECTANCE AB We report the first photoreflectance measurement of strain-induced piezoelectric field in a (111)B InGaAs/GaAs structure. The InGaAs quantum well was pseudomorphically grown in the undoped regions of a GaAs undoped-heavily doped structure. Four structures, two each with the same layer structures but different orientation, (111) B and (100), were used in this study. The electric fields in the undoped GaAs region were measured by Franz-Keldysh oscillations in photoreflectance. All the samples have a surface barrier height of about 0.7 eV. However, the measured electric field is 30% stronger in the (111)B sample compared to the (100) sample. We attribute this difference to the strain-induced electric field in the (111)B sample. The piezoelectric field in (111) B strained In0.15Ga0.85As obtained in this measurement is 2.2 +/- 0.5 X 10(5) V/cm, which agrees very well with theory. C1 UNIV MINNESOTA,MINNEAPOLIS,MN 55455. USA,RES OFF,RES TRIANGLE PK,NC 27709. RP SHEN, H (reprint author), USA,ELECTR TECHNOL & DEVICES LAB,FT MONMOUTH,NJ 07703, USA. RI Schaff, William/B-5839-2009 NR 21 TC 30 Z9 30 U1 0 U2 2 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD MAY 11 PY 1992 VL 60 IS 19 BP 2400 EP 2402 DI 10.1063/1.106985 PG 3 WC Physics, Applied SC Physics GA HT679 UT WOS:A1992HT67900028 ER PT J AU RATICK, SJ DU, W MOSER, DA AF RATICK, SJ DU, W MOSER, DA TI DEVELOPMENT OF A RELIABILITY BASED DYNAMIC DREDGING DECISION-MODEL SO EUROPEAN JOURNAL OF OPERATIONAL RESEARCH LA English DT Article DE DYNAMIC CHANCE-CONSTRAINED PROGRAMMING; UNCERTAINTY SIMULATION; CHANNEL MAINTENANCE DREDGING ID LOCATION AB Accurate forecasts of hydrological and hydraulic conditions used in planning for the maintenance of navigation channels are important for ensuring safe and cost efficient water borne transportation. The uncertainties inherent in forecasting and in the availability and operating conditions of dredges make planning difficult and may require that an uncertainty assessment be integrated into the planning process for dredging activities. This paper develops a reliability based dynamic dredging decision model that employs a simulation-optimization approach combining a hydrological simulation model of stochastic channel conditions with a dynamic location model to schedule the optimal deployment and activity levels for dredges. The benefits of this type of approach are demonstrated by application to the problem of allocating different types and sizes of dredges in order to maintain a required channel depth over time and under different reliability levels. The amounts to be dredged at any given location are incorporated into the model as chance constraints that are dependent upon the stochastic hydrologic and hydraulic channel conditions. The multiobjective optimization model assigns demobilization and mobilization costs in periods when a facility is moved from one location to another, and allows for advanced maintenance dredging, 'over-dredging' in some time periods, in order to reduce overall costs. The dredging costs considered in the model are comprised of fixed costs - assessed each period and varying by size and type of dredge employed, variable costs - dependent upon the amount of material dredged in any month, and mobilization and demobilization costs - incurred each time a dredge is moved to a new location. The multiobjective framework evaluates explicitly the manner in which dredging costs vary under different levels of reliability for maintaining the required channel depth. C1 USA,CTR WATER RESOURCES SUPPORT,INST WATER RESOURCES,FT BELVOIR,VA 22060. RP RATICK, SJ (reprint author), CLARK UNIV,CTR TECHNOL ENVIRONMENT & DEV,WORCESTER,MA 01610, USA. NR 22 TC 0 Z9 0 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0377-2217 J9 EUR J OPER RES JI Eur. J. Oper. Res. PD MAY 11 PY 1992 VL 58 IS 3 BP 318 EP 334 DI 10.1016/0377-2217(92)90063-F PG 17 WC Management; Operations Research & Management Science SC Business & Economics; Operations Research & Management Science GA JE132 UT WOS:A1992JE13200002 ER PT J AU YU, FTS WU, SD RAJAN, S GREGORY, DA AF YU, FTS WU, SD RAJAN, S GREGORY, DA TI COMPACT JOINT TRANSFORM CORRELATOR WITH A THICK PHOTOREFRACTIVE CRYSTAL SO APPLIED OPTICS LA English DT Note ID OPTICAL CORRELATOR AB A compact joint transform correlator with a thick photorefractive crystal is presented. We demonstrate that Bragg diffraction severely limits the correlation performance in a thick crystal. To relax the Bragg limitation of the crystal a Galilean telescopic beam compression technique is used in the joint transform correlator. C1 USA,MISSILE COMMAND,REDSTONE ARSENAL,AL 35809. RP YU, FTS (reprint author), PENN STATE UNIV,DEPT ELECT ENGN,UNIV PK,PA 16802, USA. NR 8 TC 13 Z9 13 U1 0 U2 0 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0003-6935 J9 APPL OPTICS JI Appl. Optics PD MAY 10 PY 1992 VL 31 IS 14 BP 2416 EP 2418 PG 3 WC Optics SC Optics GA HT103 UT WOS:A1992HT10300007 PM 20725165 ER PT J AU WONGSRICHANALAI, C CHUANAK, N WEBSTER, HK TIMASARN, K AF WONGSRICHANALAI, C CHUANAK, N WEBSTER, HK TIMASARN, K TI RAPID TEST FOR MALARIA DIAGNOSIS SO LANCET LA English DT Letter C1 REG MALARIA CTR 5,NONTHABURI,THAILAND. RP WONGSRICHANALAI, C (reprint author), ARMED FORCES RES INST MED SCI,DEPT IMMUNOL & BIOCHEM,BANGKOK 10400,THAILAND. NR 3 TC 7 Z9 7 U1 0 U2 0 PU LANCET LTD PI LONDON PA 42 BEDFORD SQUARE, LONDON, ENGLAND WC1B 3SL SN 0140-6736 J9 LANCET JI Lancet PD MAY 9 PY 1992 VL 339 IS 8802 BP 1176 EP 1176 DI 10.1016/0140-6736(92)90780-7 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA HT236 UT WOS:A1992HT23600043 PM 1349402 ER PT J AU SATAVA, RM AF SATAVA, RM TI NINTENDO SURGERY SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Letter RP SATAVA, RM (reprint author), USA,MONTEREY,CA, USA. NR 1 TC 12 Z9 12 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD MAY 6 PY 1992 VL 267 IS 17 BP 2329 EP 2330 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA HR015 UT WOS:A1992HR01500021 PM 1532994 ER PT J AU PRYOR, AN SELWOOD, T LEU, LS ANDRACKI, MA LEE, BH RAO, M ROSENBERRY, T DOCTOR, BP SILMAN, I QUINN, DM AF PRYOR, AN SELWOOD, T LEU, LS ANDRACKI, MA LEE, BH RAO, M ROSENBERRY, T DOCTOR, BP SILMAN, I QUINN, DM TI SIMPLE GENERAL ACID-BASE CATALYSIS OF PHYSIOLOGICAL ACETYLCHOLINESTERASE REACTIONS SO JOURNAL OF THE AMERICAN CHEMICAL SOCIETY LA English DT Article ID HUMAN-LEUKOCYTE ELASTASE; VIRTUAL TRANSITION-STATES; SERINE PROTEASES; REACTION DYNAMICS; HUMAN-ERYTHROCYTE; MECHANISM; ENZYMES; INTERMEDIATE; HYDROLYSIS; DEPENDENCE AB Elements of transition-state stabilization by proton bridging have been characterized by measuring solvent isotope effects and proton inventories for hydrolyses of (acetylthio)choline (ATCh), (propionylthio)choline (PrTCh), and (butyryl-thio)choline (BuTCh) catalyzed by acetylcholinesterases (AChEs) from Electrophorus electricus, fetal bovine serum, human erythrocytes, and Torpedo californica. For the Electrophorus enzyme, the acylation rate constant, k(cat)/K(m) { = (V/K)/[E]T}, decreases in the order ATCh > PrTCh >> BuTCh. Solvent isotope effects for V/K of ATCh hydrolysis are usually within experimental error of unity, which is consistent with rate determination of the acylation stage of catalysis by a physical step, such as substrate diffusion. However, as substrate reactivity decreases the isotope effect increases, which indicates that the transition state of a chemical step is increasingly rate determining. A linear proton inventory for V/K of BuTCh hydrolysis indicates that this chemical transition state is stabilized by single proton transfer. Solvent isotope effects for V are approximately 2, and the corresponding proton inventories are invariably linear, irrespective of the source of AChE, the choice of substrate, the ionic strength of the medium, or the presence of the detergent TX100. The consistency of the results strongly suggests that AChE stabilizes chemical transition states of physiological reactions by one-proton, simple general acid-base catalysis. Therefore, elaborate themes in transition-state stabilization by proton transfer, such as multifunctional or charge-relay catalyses, do not appear to operate in the physiological functioning of AChE. C1 UNIV IOWA,DEPT CHEM,IOWA CITY,IA 52242. CASE WESTERN RESERVE UNIV,DEPT PHARMACOL,CLEVELAND,OH 44106. WALTER REED ARMY MED CTR,DIV BIOCHEM,WASHINGTON,DC 20307. WEIZMANN INST SCI,DEPT NEUROBIOL,IL-76100 REHOVOT,ISRAEL. NR 42 TC 24 Z9 24 U1 0 U2 3 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0002-7863 J9 J AM CHEM SOC JI J. Am. Chem. Soc. PD MAY 6 PY 1992 VL 114 IS 10 BP 3896 EP 3900 DI 10.1021/ja00036a043 PG 5 WC Chemistry, Multidisciplinary SC Chemistry GA HT801 UT WOS:A1992HT80100043 ER PT J AU BENVENISTE, R HEIDECKER, G EDDY, G LEWIS, M BURKE, D SHAFFERMAN, A MORTON, W HU, SL AF BENVENISTE, R HEIDECKER, G EDDY, G LEWIS, M BURKE, D SHAFFERMAN, A MORTON, W HU, SL TI RECOMBINANT VACCINES PROTECT MACAQUES AGAINST HOMOLOGOUS SIV OR TYPE-D RETROVIRUS INFECTION SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract C1 NCI,FREDERICK,MD 21701. WASHINGTON PRIMATE CTR,SEATTLE,WA. JACKSON FDN,ROCKVILLE,MD. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. ISRAEL INST BIOL RES,IL-70450 NESS ZIONA,ISRAEL. ONCOGEN,SEATTLE,WA. RI Hu, Shiu-Lok/A-3196-2008 OI Hu, Shiu-Lok/0000-0003-4336-7964 NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD MAY PY 1992 VL 8 IS 5 BP 896 EP 896 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA JA513 UT WOS:A1992JA51300176 ER PT J AU SHAFFERMAN, A EDDY, GA JAHRLING, PB LEWIS, MG BENVENISTE, RE EDENMCCUTCHAN, F BURKE, DS AF SHAFFERMAN, A EDDY, GA JAHRLING, PB LEWIS, MG BENVENISTE, RE EDENMCCUTCHAN, F BURKE, DS TI PROTECTION OF MACAQUES WITH A VACCINE OF SIV ENVELOPE PEPTIDES SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract C1 ISRAEL INST BIOL RES,IL-70450 NESS ZIONA,ISRAEL. HENRY M JACKSON FDN,ROCKVILLE,MD. USA,MED RES INST INFECT DIS,FREDERICK,MD 21701. NCI,VIRAL CARCINOGENESIS LAB,BETHESDA,MD 20892. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD MAY PY 1992 VL 8 IS 5 BP 897 EP 897 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA JA513 UT WOS:A1992JA51300179 ER PT J AU ROSENBERG, YJ WHITE, BD PAPERMASTER, SF ZACK, PM JARLING, PB EDDY, GA BURKE, DS LEWIS, MG JACKSON, HM AF ROSENBERG, YJ WHITE, BD PAPERMASTER, SF ZACK, PM JARLING, PB EDDY, GA BURKE, DS LEWIS, MG JACKSON, HM TI DECLINE IN THE CD4-PERCENT AND CD4/CD8 RATIOS IN BLOOD OF SIV INFECTED MONKEYS IS NOT ACCOMPANIED BY CONCOMITANT DECREASES WITHIN THE CD4+ POOL PRESENT IN LYMPH-NODES AND SPLEEN SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract C1 HENRY M JACKSON FDN,RES LAB,ROCKVILLE,MD. WRAIR,ROCKVILLE,MD. USA,MED RES INST INFECT DIS,FREDERICK,MD 21701. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD MAY PY 1992 VL 8 IS 5 BP 902 EP 902 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA JA513 UT WOS:A1992JA51300196 ER PT J AU MICHAEL, NL VAHEY, M BURKE, DS REDFIELD, RR AF MICHAEL, NL VAHEY, M BURKE, DS REDFIELD, RR TI THE RELATIONSHIP BETWEEN VIRAL-DNA AND MESSENGER-RNA EXPRESSION DEFINE INTERVALS OF HIV-1 DISEASE PROGRESSION IN HUMANS SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,DEPT RETROVIRAL RES,DIV RETROVIROL,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD MAY PY 1992 VL 8 IS 5 BP 914 EP 914 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA JA513 UT WOS:A1992JA51300240 ER PT J AU GENDELMAN, HE FRIEDMAN, RM SILVERMAN, R MELTZER, MS AF GENDELMAN, HE FRIEDMAN, RM SILVERMAN, R MELTZER, MS TI INVESTIGATIONS INTO THE MECHANISM(S) OF INTERFERON-INDUCED RESTRICTION OF HUMAN IMMUNODEFICIENCY VIRAL-INFECTION SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,DEPT CELLULAR IMMUNOL,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,DEPT PATHOL,BETHESDA,MD 20850. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD MAY PY 1992 VL 8 IS 5 BP 919 EP 919 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA JA513 UT WOS:A1992JA51300255 ER PT J AU REDFIELD, R BIRX, D KETTER, N POLONIS, V JOHNSON, S DAVIS, C SMITH, G OSTER, C BURKE, D AF REDFIELD, R BIRX, D KETTER, N POLONIS, V JOHNSON, S DAVIS, C SMITH, G OSTER, C BURKE, D TI VACCINE THERAPY USING RGP 160 IN EARLY HIV-INFECTION SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT RETROVIRAL RES,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD MAY PY 1992 VL 8 IS 5 BP 937 EP 937 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA JA513 UT WOS:A1992JA51300322 ER PT J AU AGGARWAL, A SADOFF, J MARKHAM, P GARD, E FUERST, T GALLO, RC FRANCHINI, G AF AGGARWAL, A SADOFF, J MARKHAM, P GARD, E FUERST, T GALLO, RC FRANCHINI, G TI HIV-2 RECOMBINANT VACCINES INDUCE CD8+ SPECIFIC CYTOTOXIC LYMPHOCYTES-T IN RODENTS AND PRIMATES SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract C1 NIH,TUMOR CELL BIOL LAB,BETHESDA,MD 20892. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. ADV BIOTECHNOL LABS,KENSINGTON,MD. MEDIMMUNE,GAITHERSBURG,MD. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD MAY PY 1992 VL 8 IS 5 BP 942 EP 942 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA JA513 UT WOS:A1992JA51300338 ER PT J AU SADOFF, J AGGARWAL, A BARON, L HONG, H ELSINGHORST, E LANAR, D WARREN, R AF SADOFF, J AGGARWAL, A BARON, L HONG, H ELSINGHORST, E LANAR, D WARREN, R TI LIVE ORAL RECOMBINANT SALMONELLA CARRIER VACCINES SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NIH,BETHESDA,MD 20892. RI Lanar, David/B-3560-2011 NR 0 TC 1 Z9 1 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD MAY PY 1992 VL 8 IS 5 BP 942 EP 942 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA JA513 UT WOS:A1992JA51300336 ER PT J AU BIRX, DL LOOMIS, L VANCOTT, T KERSEY, K PUTNEY, S BURKE, D ROBERTS, C REDFIELD, RR AF BIRX, DL LOOMIS, L VANCOTT, T KERSEY, K PUTNEY, S BURKE, D ROBERTS, C REDFIELD, RR TI RESTRICTED V3 REACTIVITY ASSOCIATED WITH CLINICAL HIV STAGE SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. REPLIGEN CORP,CAMBRIDGE,MA. HENRY M JACKSON FDN,ROCKVILLE,MD. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD MAY PY 1992 VL 8 IS 5 BP 948 EP 948 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA JA513 UT WOS:A1992JA51300360 ER PT J AU HAIBACH, H BURNS, TW CARLSON, HE BURMAN, KD DEFTOS, LJ AF HAIBACH, H BURNS, TW CARLSON, HE BURMAN, KD DEFTOS, LJ TI MULTIPLE HAMARTOMA SYNDROME (COWDENS DISEASE) ASSOCIATED WITH RENAL-CELL CARCINOMA AND PRIMARY NEUROENDOCRINE CARCINOMA OF THE SKIN (MERKEL CELL-CARCINOMA) SO AMERICAN JOURNAL OF CLINICAL PATHOLOGY LA English DT Article ID EPIDERMAL-GROWTH-FACTOR; FACTOR RECEPTOR GENE; TRABECULAR CARCINOMA; BREAST-CANCER; AMPLIFICATION; EXPRESSION; LESIONS; MARKER; TUMORS; LINES AB A case of multiple hamartoma syndrome (Cowden's disease) associated with renal cell adenocarcinoma and primary neuroendocrine carcinoma of the skin is described. Neither of these neoplasms has been documented previously in association with this genodermatosis. A search for epidermal growth factor receptor (c-erb-B protooncogene) gene abnormalities in the kidney, liver, and thyroid, as well as in tissue of the primary neuroendocrine carcinoma, was negative. Serum obtained from the patient before his death contained elevated levels of both chromogranin A (2641 ng/mL; normal level, < 20 ng/mL) and calcitonin (517 pg/mL; normal level, < 200 pg/mL), suggesting that the patient's principal tumor was neuroendocrine in origin. C1 UNIV MISSOURI,COSMOPOLITAN INT DIABET CTR,DEPT INTERNAL MED,1 HOSP DR,COLUMBIA,MO 65212. WALTER REED ARMY MED CTR,ENDOCRINE SERV,KYLE METAB,WASHINGTON,DC 20307. NORTHPORT VET ADM MED CTR,MED & RES SERV,STONY BROOK,NY. SUNY STONY BROOK,DEPT MED,STONY BROOK,NY 11794. UNIV CALIF SAN DIEGO,DEPT MED,LA JOLLA,CA 92093. VET ADM MED CTR,LA JOLLA,CA. UNIV MISSOURI,COSMOPOLITIAN INT DIABET CTR,DEPT PATHOL,COLUMBIA,MO 65212. NR 34 TC 40 Z9 41 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0002-9173 J9 AM J CLIN PATHOL JI Am. J. Clin. Pathol. PD MAY PY 1992 VL 97 IS 5 BP 705 EP 712 PG 8 WC Pathology SC Pathology GA HR677 UT WOS:A1992HR67700019 PM 1575215 ER PT J AU LOTTON, RB PIERSON, JF HOFFMAN, W AF LOTTON, RB PIERSON, JF HOFFMAN, W TI EXPERIENCES OF A COMBAT SUPPORT HOSPITAL PHARMACY SERVICE DURING OPERATION DESERT STORM SO AMERICAN JOURNAL OF HOSPITAL PHARMACY LA English DT Article RP LOTTON, RB (reprint author), USA,MED SERV CORPS,STN HOSP 225,PHARM SERV,NEW YORK,NY 09252, USA. NR 3 TC 2 Z9 2 U1 0 U2 0 PU AMER SOC HEALTH-SYSTEM PHARMACISTS PI BETHESDA PA 7272 WISCONSIN AVE, BETHESDA, MD 20814 SN 0002-9289 J9 AM J HOSP PHARM JI Am. J. Hosp. Pharm. PD MAY PY 1992 VL 49 IS 5 BP 1152 EP 1155 PG 4 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA HR493 UT WOS:A1992HR49300021 PM 1595746 ER PT J AU SHANLEY, DJ SISLER, CL AF SHANLEY, DJ SISLER, CL TI MR DEMONSTRATION OF REVERSIBLE CEREBRAL-LESIONS IN A CHILD WITH HYPERTENSIVE ENCEPHALOPATHY CAUSED BY WILMS-TUMOR SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Article ID PREGNANCY; TOXEMIA RP SHANLEY, DJ (reprint author), TRIPLER ARMY MED CTR,DEPT RADIOL,HONOLULU,HI 96859, USA. NR 8 TC 8 Z9 8 U1 0 U2 0 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR, SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 SN 0361-803X J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD MAY PY 1992 VL 158 IS 5 BP 1161 EP 1162 PG 2 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA HQ193 UT WOS:A1992HQ19300042 PM 1314476 ER PT J AU AZAROW, KS PEARL, RH HOFFMAN, MA ZURCHER, R EDWARDS, FH COHEN, AJ AF AZAROW, KS PEARL, RH HOFFMAN, MA ZURCHER, R EDWARDS, FH COHEN, AJ TI VASCULAR RING - DOES MAGNETIC-RESONANCE-IMAGING REPLACE ANGIOGRAPHY SO ANNALS OF THORACIC SURGERY LA English DT Article ID AORTIC-ARCH; SURGICAL-MANAGEMENT AB The records of 21 patients who underwent operation for symptoms attributable to vascular ring were reviewed. The study covered 33 years, 1958 to 1991, and the mean follow-up was 6.8 years. The patients ranged from 7 days to 26 years old with a mean age of 2.9 years. Twenty patients were symptomatic. Symptoms were due to tracheal compression in 16 patients, esophageal compression in 2, and both causes in 2. During the first 30 years, chest roentgenography, barium swallow, and aortography constituted the diagnostic workup in the majority of the patients. During the last 3 years, magnetic resonance imaging replaced aortography. The surgical diagnosis included five variants of vascular ring. The surgical approach consisted of left thoracotomy in 19 patients and right thoracotomy in 2. These 2 had the diagnosis of right aortic arch with posterior left subclavian artery. In both instances, preoperative angiographic data determined the surgical approach. Barium swallow may be sufficient for the diagnosis of vascular ring; however, additional data are useful in determining the surgical approach. Magnetic resonance imaging can yield accurate data without subjecting the patient to the risks associated with angiography. C1 WALTER REED ARMY MED CTR,DEPT SURG,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,DEPT SURG,BETHESDA,MD 20814. NR 21 TC 36 Z9 36 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0003-4975 J9 ANN THORAC SURG JI Ann. Thorac. Surg. PD MAY PY 1992 VL 53 IS 5 BP 882 EP 885 PG 4 WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery SC Cardiovascular System & Cardiology; Respiratory System; Surgery GA HR476 UT WOS:A1992HR47600027 PM 1570988 ER PT J AU SHARKEY, MJ KELLER, RA GRABSKI, WJ MCCOLLOUGH, ML AF SHARKEY, MJ KELLER, RA GRABSKI, WJ MCCOLLOUGH, ML TI FAVRE-RACOUCHOT SYNDROME - A COMBINED THERAPEUTIC APPROACH SO ARCHIVES OF DERMATOLOGY LA English DT Article RP SHARKEY, MJ (reprint author), BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234, USA. NR 13 TC 12 Z9 12 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0003-987X J9 ARCH DERMATOL JI Arch. Dermatol. PD MAY PY 1992 VL 128 IS 5 BP 615 EP 616 DI 10.1001/archderm.128.5.615 PG 2 WC Dermatology SC Dermatology GA HU003 UT WOS:A1992HU00300002 PM 1575522 ER PT J AU VAUGHN, RY GUILL, MA COOK, J AF VAUGHN, RY GUILL, MA COOK, J TI ATROPHIC PLAQUES IN A NEONATE SO ARCHIVES OF DERMATOLOGY LA English DT Note ID LUPUS-ERYTHEMATOSUS; ANTIGEN; SKIN C1 DWIGHT D EISENHOWER ARMY MED CTR,FT GORDON,GA 30905. RP VAUGHN, RY (reprint author), MED COLL GEORGIA,AUGUSTA,GA 30912, USA. NR 11 TC 2 Z9 2 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0003-987X J9 ARCH DERMATOL JI Arch. Dermatol. PD MAY PY 1992 VL 128 IS 5 BP 681 EP & PG 0 WC Dermatology SC Dermatology GA HU003 UT WOS:A1992HU00300020 ER PT J AU BROWN, JS AF BROWN, JS TI PHOSPHOMONOESTERS AND PHOSPHODIESTERS IN THE BRAINS OF SCHIZOPHRENIC-PATIENTS SO ARCHIVES OF GENERAL PSYCHIATRY LA English DT Letter RP BROWN, JS (reprint author), WALTER REED ARMY MED CTR,DEPT PSYCHIAT,WASHINGTON,DC 20307, USA. NR 4 TC 1 Z9 1 U1 0 U2 1 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0003-990X J9 ARCH GEN PSYCHIAT JI Arch. Gen. Psychiatry PD MAY PY 1992 VL 49 IS 5 BP 416 EP 416 PG 1 WC Psychiatry SC Psychiatry GA HV122 UT WOS:A1992HV12200015 PM 1586279 ER PT J AU KROENKE, K LAWRENCE, VA THEROUX, JF TULEY, MR AF KROENKE, K LAWRENCE, VA THEROUX, JF TULEY, MR TI OPERATIVE RISK IN PATIENTS WITH SEVERE OBSTRUCTIVE PULMONARY-DISEASE SO ARCHIVES OF INTERNAL MEDICINE LA English DT Article ID UPPER ABDOMINAL-SURGERY; PREOPERATIVE SPIROMETRY; SURGICAL PROCEDURES; CARDIAC-SURGERY; CLINICAL COURSE; COMPLICATIONS; ANESTHESIA; PREVENTION; INDEX AB Background. - We wanted to determine the risk of postoperative pulmonary complications and mortality in patients with severe chronic obstructive pulmonary disease. Methods. - We reviewed 107 consecutive operations performed in 89 patients with severe chronic obstructive pulmonary disease (forced expiratory volume in 1 second, < 50% of predicted). Results. - Postoperative pulmonary complications occurred in 31 operations (29%) and were significantly related to the type and duration of surgery. Also, American Society of Anesthesiologists class approached significance as a predictor. Postoperative pulmonary complications occurred at higher rates in coronary artery bypass grafting and major abdominal procedures (60% and 56%) than in other operations involving general or spinal anesthesia (27%) or in procedures performed with the patient under regional or local anesthesia (16%). When the durations of the operations were classified as less than 1 hour, 1 to 2 hours, 2 to 4 hours, and more than 4 hours, the rates of postoperative pulmonary complications were 4%, 23%, 38%, and 73%, respectively. Regarding American Society of Anesthesiologists class, postoperative pulmonary complications occurred in 10% of patients in class II, 28% of those in class III, and 46% of those in class IV. In terms of life-threatening complications, there were six deaths and only two cases of nonfatal ventilatory failure. Notably, mortality clustered primarily in coronary artery bypass graft procedures. Five of 10 patients receiving coronary artery bypass grafts died, compared with one death after 97 non-coronary artery bypass graft operations (50% vs 1%). Conclusions. - Although the risk of coronary artery bypass grafting deserves further study, noncardiac surgery carries an acceptable operative risk in patients with severe chronic obstructive pulmonary disease. C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. UNIV TEXAS,HLTH SCI CTR,DEPT MED,DIV GEN INTERNAL MED,SAN ANTONIO,TX 78284. AUDIE L MURPHY MEM VET ADM MED CTR,SAN ANTONIO,TX 78284. BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234. RP KROENKE, K (reprint author), UNIFORMED SERV UNIV HLTH SCI,DEPT MED,BETHESDA,MD 20814, USA. NR 30 TC 84 Z9 93 U1 0 U2 1 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0003-9926 J9 ARCH INTERN MED JI Arch. Intern. Med. PD MAY PY 1992 VL 152 IS 5 BP 967 EP 971 DI 10.1001/archinte.152.5.967 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA HU616 UT WOS:A1992HU61600011 PM 1580723 ER PT J AU SOGN, DD EVANS, R SHEPHERD, GM CASALE, TB CONDEMI, J GREENBERGER, PA KOHLER, PF SAXON, A SUMMERS, RJ VANARSDEL, PP MASSICOT, JG BLACKWELDER, WC LEVINE, BB AF SOGN, DD EVANS, R SHEPHERD, GM CASALE, TB CONDEMI, J GREENBERGER, PA KOHLER, PF SAXON, A SUMMERS, RJ VANARSDEL, PP MASSICOT, JG BLACKWELDER, WC LEVINE, BB TI RESULTS OF THE NATIONAL-INSTITUTE-OF-ALLERGY-AND-INFECTIOUS-DISEASES COLLABORATIVE CLINICAL-TRIAL TO TEST THE PREDICTIVE VALUE OF SKIN TESTING WITH MAJOR AND MINOR PENICILLIN DERIVATIVES IN HOSPITALIZED ADULTS SO ARCHIVES OF INTERNAL MEDICINE LA English DT Article ID HYPERSENSITIVITY; EXPERIENCE; DIAGNOSIS AB Background. - A history (or lack thereof) of penicillin allergy is known to be unreliable in predicting reactions on subsequent administration of the drug. This study tests the usefulness of four penicillin allergen skin tests in the prediction of IgE-mediated reactions subsequent to administration of penicillin. Methods. - Eight centers cooperated in the National Institute of Allergy and Infectious Diseases trial of the predictive value of skin testing with major and minor penicillin derivatives. Hospitalized adults were tested with a major determinant (octa-benzylpenicilloyl-octalysine) and a minor determinant mixture and its components (potassium benzylpenicillin, benzylpenicilloate, and benzylpenicilloyl-N-propylamine). Patients then received a therapeutic course of penicillin and were observed, for 48 hours, for adverse reactions compatible with an IgE-mediated immediate or accelerated allergy. Results. - Among 726 history-positive patients, 566 with negative skin tests received penicillin and only seven (1.2%) had possibly IgE-mediated reactions. Among 600 history-negative patients, 568 with negative skin tests received penicillin and none had a reaction. Only nine of the 167 positive skin test reactors received a penicillin agent and then usually by cautious incremental dosing. Two (22%) of these nine patients had reactions compatible with IgE-mediated immediate or accelerated penicillin allergy; both were positive to the two determinants. Conclusions. - These data corroborate previous data about the negative predictive value of negative skin tests to these materials. The reaction rate in skin test-positive patients was significantly higher than in those with negative skin tests, demonstrating the positive predictive value of positive tests to both major and minor determinants. The number of patients positive only to the major determinant or only to the minor determinant mix was too small to draw conclusions about the positive predictive value of either reagent alone. C1 NIAID,BETHESDA,MD 20892. NIH,NATL CTR RES RESOURCES,BETHESDA,MD 20892. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NORTHWESTERN UNIV,CHICAGO,IL 60611. CORNELL UNIV,ITHACA,NY 14853. UNIV IOWA,IOWA CITY,IA 52242. UNIV ROCHESTER,ROCHESTER,NY 14627. UNIV COLORADO,DENVER,CO 80202. TULANE UNIV,NEW ORLEANS,LA 70118. UNIV CALIF LOS ANGELES,LOS ANGELES,CA 90024. UNIV WASHINGTON,SEATTLE,WA 98195. NHLBI,BETHESDA,MD 20892. NYU,NEW YORK,NY 10003. RI Casale, Thomas/K-4334-2013 OI Casale, Thomas/0000-0002-3149-7377 FU NIAID NIH HHS [N01 AI-92629, N01 AI-92630, N01 AI-92631] NR 21 TC 187 Z9 191 U1 1 U2 5 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0003-9926 J9 ARCH INTERN MED JI Arch. Intern. Med. PD MAY PY 1992 VL 152 IS 5 BP 1025 EP 1032 DI 10.1001/archinte.152.5.1025 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA HU616 UT WOS:A1992HU61600020 PM 1580706 ER PT J AU JAHRLING, PB PETERS, CJ AF JAHRLING, PB PETERS, CJ TI LYMPHOCYTIC CHORIOMENINGITIS VIRUS - A NEGLECTED PATHOGEN OF MAN SO ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE LA English DT Editorial Material ID HEMORRHAGIC-FEVER; INFECTION; HANTAAN; MICE RP JAHRLING, PB (reprint author), USA, INFECT DIS RES INST, DIV DIS ASSESSMENT, FREDERICK, MD 21701 USA. NR 31 TC 74 Z9 79 U1 0 U2 1 PU COLL AMER PATHOLOGISTS PI NORTHFIELD PA C/O KIMBERLY GACKI, 325 WAUKEGAN RD, NORTHFIELD, IL 60093-2750 USA SN 0003-9985 EI 1543-2165 J9 ARCH PATHOL LAB MED JI Arch. Pathol. Lab. Med. PD MAY PY 1992 VL 116 IS 5 BP 486 EP 488 PG 3 WC Medical Laboratory Technology; Medicine, Research & Experimental; Pathology SC Medical Laboratory Technology; Research & Experimental Medicine; Pathology GA HR880 UT WOS:A1992HR88000010 PM 1316111 ER PT J AU STURM, M AF STURM, M TI SNOW DISTRIBUTION AND HEAT-FLOW IN THE TAIGA SO ARCTIC AND ALPINE RESEARCH LA English DT Article ID FOREST AB The trees of the taiga intercept falling snow and cause it to become distributed in an uneven fashion. Around aspen and birch, cone-shaped accumulations form. Beneath large spruce trees, the snow cover is depleted, forming a bowl-shaped depression called a tree well. Small spruce trees become covered with snow, creating cavities that funnel cold air to the snow/ground interface. The depletion of snow under large spruce trees results in greater heat loss from the ground. A finite difference model suggests that heat flow from tree wells can be more than twice that of undisturbed snow. In forested watersheds, this increase can be a significant percentage of the total winter energy exchange. RP STURM, M (reprint author), USA,COLD REG RES & ENGN LAB,BLDG 4070,FT WAINWRIGHT,AK 99703, USA. NR 22 TC 41 Z9 43 U1 2 U2 5 PU INST ARCTIC ALPINE RES PI BOULDER PA UNIV COLORADO, BOULDER, CO 80309 SN 0004-0851 J9 ARCTIC ALPINE RES JI Arct. Alp. Res. PD MAY PY 1992 VL 24 IS 2 BP 145 EP 152 DI 10.2307/1551534 PG 8 WC Environmental Sciences; Geography SC Environmental Sciences & Ecology; Geography GA HU713 UT WOS:A1992HU71300005 ER PT J AU ARMSTRONG, LE SZLYK, PC DELUCA, JP SILS, IV HUBBARD, RW AF ARMSTRONG, LE SZLYK, PC DELUCA, JP SILS, IV HUBBARD, RW TI FLUID-ELECTROLYTE LOSSES IN UNIFORMS DURING PROLONGED EXERCISE AT 30-DEGREES-C SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article ID HEAT AB The effects of several uniform configurations on fluid and electrolyte losses in a hot environment (30-degrees-C db, 18-degrees-C wb) were studied in 15 healthy males, during 6 h of intermittent treadmill exercise (1.56 m.s-1, 0% grade, 50 min.h-1, 28 km total distance). The uniforms were: the temperate battle dress uniform (BDU), two variants (C and F) of full military oriented protective posture (MOPP IV), and MOPP IV with no mask or hood (M). Sweat rate, urine volume, electrolyte losses (Na+, Cl-, K+, Mg++, Ca++) in sweat and urine, rectal temperature, mean skin temperature, heart rate, and temperature/humidity inside uniforms were measured. Observations indicated that both MOPP IV configurations (C and F) resulted in significantly greater (p. < 0.05) fluid losses and physiological strain than BDU and M. However, there were no between-uniform differences in the total loss of any electrolyte. Total body fluid losses (kg . 6h-1) and electrolyte losses in sweat (mEq . 6h-1) were consistently greater than in urine. It was concluded that 6 h of exercise in uniforms at 30-degrees-C can result in losses of Na+ and Ca++ which exceed the normal daily intake of these electrolytes. Supplementation of fluid, Na+, and Ca++ appears to be warranted when scenarios require 6 h or more of uniformed exposure to heat. C1 USA,ENVIRONM MED RES INST,DIV HEAT RES,NATICK,MA 01760. RP ARMSTRONG, LE (reprint author), UNIV CONNECTICUT,DEPT SPORT LEISURE & EXERCISE SCI,HUMAN PERFORMANCE LAB,BOX U-110,STORRS,CT 06269, USA. NR 25 TC 12 Z9 12 U1 0 U2 0 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD MAY PY 1992 VL 63 IS 5 BP 351 EP 355 PG 5 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA HR212 UT WOS:A1992HR21200003 PM 1599380 ER PT J AU CARTER, JM VANALBERT, S LEE, J LYON, J DEAL, C AF CARTER, JM VANALBERT, S LEE, J LYON, J DEAL, C TI SHEDDING LIGHT ON PEPTIDE-SYNTHESIS SO BIO-TECHNOLOGY LA English DT Article ID EPITOPES RP CARTER, JM (reprint author), WALTER REED ARMY MED CTR,WASHINGTON,DC 20307, USA. RI Carter, John Mark/K-2485-2015 OI Carter, John Mark/0000-0001-8251-4168 NR 12 TC 12 Z9 12 U1 0 U2 0 PU NATURE PUBLISHING CO PI NEW YORK PA 345 PARK AVE SOUTH, NEW YORK, NY 10010-1707 SN 0733-222X J9 BIO-TECHNOL JI Bio-Technology PD MAY PY 1992 VL 10 IS 5 BP 509 EP & DI 10.1038/nbt0592-509 PG 0 WC Biotechnology & Applied Microbiology SC Biotechnology & Applied Microbiology GA HV441 UT WOS:A1992HV44100017 PM 1368231 ER PT J AU KRISHNAMURTI, C BOLAN, CD REID, TJ ALVING, BM AF KRISHNAMURTI, C BOLAN, CD REID, TJ ALVING, BM TI PHARMACOLOGY AND MECHANISM OF ACTION OF ANCROD - POTENTIAL FOR INDUCING THROMBOSIS SO BLOOD LA English DT Letter ID PLASMINOGEN RP KRISHNAMURTI, C (reprint author), WALTER REED ARMY MED CTR,DEPT HEMATOL,WASHINGTON,DC 20307, USA. NR 8 TC 11 Z9 11 U1 1 U2 1 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0006-4971 J9 BLOOD JI Blood PD MAY 1 PY 1992 VL 79 IS 9 BP 2492 EP 2492 PG 1 WC Hematology SC Hematology GA HW884 UT WOS:A1992HW88400043 PM 1571563 ER PT J AU CAMPBELL, CBG AF CAMPBELL, CBG TI BOORD,ROBERT,L. - 30 YEARS OF COMPARATIVE NEUROANATOMY SO BRAIN BEHAVIOR AND EVOLUTION LA English DT Item About an Individual RP CAMPBELL, CBG (reprint author), WALTER REED ARMY MED CTR,DIV NEUROPSYCHIAT,WASHINGTON,DC 20307, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU KARGER PI BASEL PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND SN 0006-8977 J9 BRAIN BEHAV EVOLUT JI Brain Behav. Evol. PD MAY PY 1992 VL 39 IS 5 BP 325 EP 328 DI 10.1159/000114129 PG 4 WC Behavioral Sciences; Neurosciences; Zoology SC Behavioral Sciences; Neurosciences & Neurology; Zoology GA JE289 UT WOS:A1992JE28900007 PM 1498654 ER PT J AU SHIH, TM SCREMIN, OU AF SHIH, TM SCREMIN, OU TI CEREBRAL BLOOD-FLOW AND METABOLISM IN SOMAN-INDUCED CONVULSIONS SO BRAIN RESEARCH BULLETIN LA English DT Article DE SOMAN; ORGANOPHOSPHORUS CHOLINESTERASE INHIBITOR; CONVULSIONS; AUTORADIOGRAPHY; PLASMA GLUCOSE; CEREBRAL BLOOD FLOW; CEREBRAL GLUCOSE UTILIZATION; BRAIN LESIONS; RAT ID REGIONAL GLUCOSE USE; SUBSTANTIA NIGRA; STATUS EPILEPTICUS; INDUCED SEIZURES; BRAIN; RAT; PATHOLOGY; PRETREATMENT; BICUCULLINE; PROTECTION AB Regional cerebral blood flow (CBF) and regional cerebral glucose utilization (CGU) were studied by quantitative autoradiographic techniques in rats. Animals were treated either with a toxic dose of soman, an irreversible organophosphorus cholinesterase inhibitor, that produced convulsions or with saline as controls. An increased arterial blood pressure (mean increase = 41% of control) always preceded onset of convulsions. Convulsive activity was associated with an increase of plasma glucose concentration and marked increases over controls of CGU [average of all regions: control = 75 +/- 5-mu-mol.100 g-1.min-1, n = regions/animals (304/8); seizures = 451 +/- 20-mu-mol.100 g-1.min-1, n = 190/5] and CBF [averate of all regions: control = 135 +/- 6 ml.100 g-1.min-1, n = 190/5; seizures = 619 +/- 29 ml.100 g-1.min-1, n = 190/5). Regional distribution of these effects revealed a greater proportional increase of CBF over CGU in cingulate, motor, and occipital cortex and caudateputamen. In contrast, a lower proportional increase of CBF over CGU in CA3 region of hippocampus, dentate gyrus, medial thalamus, and substania nigra was observed, implying the existence of a relative ischemia in these brain areas. These findings may be relevant to the pathogenesis of brain lesions associated with soman-induced convulsions. C1 VET AFFAIRS MED CTR,ALBUQUERQUE,NM 87108. UNIV NEW MEXICO,DEPT NEUROL,ALBUQUERQUE,NM 87108. RP SHIH, TM (reprint author), USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010, USA. NR 54 TC 16 Z9 17 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0361-9230 J9 BRAIN RES BULL JI Brain Res. Bull. PD MAY PY 1992 VL 28 IS 5 BP 735 EP 742 DI 10.1016/0361-9230(92)90253-T PG 8 WC Neurosciences SC Neurosciences & Neurology GA HU783 UT WOS:A1992HU78300011 PM 1617457 ER PT J AU MOUL, JW AF MOUL, JW TI REFUSAL IN TESTICULAR CANCER-PATIENTS - IMPLICATIONS FOR SURVEILLANCE SO BRITISH JOURNAL OF CANCER LA English DT Letter C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. RP MOUL, JW (reprint author), UNIFORMED SERV UNIV HLTH SCI,SURG,BETHESDA,MD 20814, USA. NR 7 TC 1 Z9 1 U1 0 U2 0 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 0007-0920 J9 BRIT J CANCER JI Br. J. Cancer PD MAY PY 1992 VL 65 IS 5 BP 786 EP 786 DI 10.1038/bjc.1992.168 PG 1 WC Oncology SC Oncology GA HR521 UT WOS:A1992HR52100032 PM 1586611 ER PT J AU LOTT, JA MITCHELL, LC MOESCHBERGER, ML SUTHERLAND, DE AF LOTT, JA MITCHELL, LC MOESCHBERGER, ML SUTHERLAND, DE TI ESTIMATION OF REFERENCE RANGES - HOW MANY SUBJECTS ARE NEEDED SO CLINICAL CHEMISTRY LA English DT Article DE NONPARAMETRIC STATISTICS; REFERENCE VALUES; SODIUM; POTASSIUM; CHLORIDE; GLUCOSE; HEMOGLOBIN; ERYTHROCYTES; HEMATOCRIT; HYPOGLYCEMIA AB We measured Na, K, Cl, glucose, hemoglobin, erythrocytes, and hematocrit in the serum or blood from approximately 800 male and 200 female second-year medical students in an effort to define the size of an acceptable reference population. Using the data from the men and Monte Carlo simulations of 10-400 samples, each carried out 5000 times, we found that for most of the above tests, approximately 200 people are required for stable lower (2.5%) and upper (97.5%) reference limits to be obtained. This agrees with the 198 subjects required by strictly statistical criteria to define the same limits with a 99% confidence level. C1 OHIO STATE UNIV,DEPT PREVENT MED,COLUMBUS,OH 43210. DWIGHT D EISENHOWER ARMY MED CTR,FT GORDON,GA 30905. RP LOTT, JA (reprint author), OHIO STATE UNIV,DEPT PATHOL,STARLING LOVING HALL M-368,COLUMBUS,OH 43210, USA. RI Mitchell, Gladys/E-7973-2012 NR 11 TC 27 Z9 27 U1 0 U2 3 PU AMER ASSOC CLINICAL CHEMISTRY PI WASHINGTON PA 2101 L STREET NW, SUITE 202, WASHINGTON, DC 20037-1526 SN 0009-9147 J9 CLIN CHEM JI Clin. Chem. PD MAY PY 1992 VL 38 IS 5 BP 648 EP 650 PG 3 WC Medical Laboratory Technology SC Medical Laboratory Technology GA HU749 UT WOS:A1992HU74900007 PM 1582014 ER PT J AU KELLY, JW DOOLEY, DP LATTUADA, CP SMITH, CE AF KELLY, JW DOOLEY, DP LATTUADA, CP SMITH, CE TI A SEVERE, UNUSUAL REACTION TO TRIMETHOPRIM-SULFAMETHOXAZOLE IN PATIENTS INFECTED WITH HUMAN-IMMUNODEFICIENCY-VIRUS SO CLINICAL INFECTIOUS DISEASES LA English DT Article ID TUMOR NECROSIS FACTOR; PNEUMOCYSTIS-CARINII PNEUMONIA; AIDS-RELATED COMPLEX; IMMUNE-DEFICIENCY SYNDROME; SEPTIC SHOCK; DESENSITIZATION; CIPROFLOXACIN; ANAPHYLAXIS; ENDOTOXIN AB The clinical features of three patients with a life-threatening reaction to trimethoprim-sulfamethoxazole (TMP-SMZ) are presented along with seven other cases from the literature. All patients developed sudden fever and hypotension immediately after the administration of TMP-SMZ; usually this reaction occurred within approximately 2 weeks of completion of a previous course of the drug. All but one patient had a rash. Most patients were hypoxemic and developed diffuse pulmonary infiltrates. All patients responded rapidly to supportive care, while bacterial cultures remained negative. The presence, absence, or character of previous adverse reactions to TMP-SMZ did not predict subsequent severe reactions. Although its mechanism remains unclear, this reaction has features of both IgE-mediated anaphylaxis and cytokine (tumor necrosis factor)-mediated effects. We advise extreme caution, with close observation, when this drug is first readministered to patients who have experienced any TMP-SMZ-associated toxicity within the previous 6-8 weeks. C1 WILFORD HALL USAF MED CTR,LACKLAND AFB,TX 78236. BROOKE ARMY MED CTR,INFECT DIS SERV,FT SAM HOUSTON,TX 78234. NR 30 TC 56 Z9 57 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 1058-4838 J9 CLIN INFECT DIS JI Clin. Infect. Dis. PD MAY PY 1992 VL 14 IS 5 BP 1034 EP 1039 PG 6 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA HQ569 UT WOS:A1992HQ56900007 PM 1600003 ER PT J AU BUDD, SE PADOVE, LB HEIRONIMUS, JD AF BUDD, SE PADOVE, LB HEIRONIMUS, JD TI EFFECT OF DILANTIN ON MYOCARDIAL UPTAKE OF TL-201 THALLOUS CHLORIDE - A CASE-REPORT SO CLINICAL NUCLEAR MEDICINE LA English DT Article ID THALLIUM AB Dilantin has been reported to decrease myocardial uptake of Tl-201 thallous chloride by as much as 38.8% in rats. To date, no studies have been done in humans to document the effect of dilantin on the myocardial uptake of thallium or its effect clinically on the interpretation of images obtained while on dilantin. The authors report a case in which simultaneous exercise echocardiogram and Tl-201 myocardial scintigraphy and serial Tl-201 myocardial scintigraphy were performed but revealed no adverse effect on image quality or interpretation. C1 BROOKE ARMY MED CTR,DEPT MED,CARDIOL SERV,FT SAM HOUSTON,TX 78234. RP BUDD, SE (reprint author), BROOKE ARMY MED CTR,DEPT RADIOL,NUCL MED SERV,FT SAM HOUSTON,TX 78234, USA. NR 6 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0363-9762 J9 CLIN NUCL MED JI Clin. Nucl. Med. PD MAY PY 1992 VL 17 IS 5 BP 375 EP 377 DI 10.1097/00003072-199205000-00007 PG 3 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA HT610 UT WOS:A1992HT61000007 PM 1587043 ER PT J AU HEINS, DC BAKER, JA DUNLAP, WP AF HEINS, DC BAKER, JA DUNLAP, WP TI YOLK LOADING IN OOCYTES OF DARTERS AND ITS CONSEQUENCES FOR LIFE-HISTORY STUDY SO COPEIA LA English DT Article ID MULTIPLE CLUTCHES; GROWTH; FISH AB Yolk loading in oocytes of oviparous fishes may affect size and variation of developing eggs at different stages in the production of a clutch. Three sequential stages of clutch or ovum development are recognized: mature, ripening, and ripe. We tested four hypotheses that describe differences in size and variation of the masses of developing eggs among the three stages of development: (1) yolk loading does not occur between mature-oocyte and ripe-egg stages, resulting in constant means and standard deviations of egg weights during clutch development; (2) yolk loading occurs at a similar rate for all oocytes in a clutch, maintaining a constant standard deviation as mean weight increases; (3) yolk loading favors smaller oocytes in a clutch, allowing them to catch up in weight with larger oocytes and decreasing the standard deviation as mean weight increases; (4) yolk loading occurs until oocytes reach a certain size, at which point it ceases completely in those oocytes reaching the maximum size (ceiling effect), decreasing variation as mean weight increases and resulting in a negatively skewed distribution of sizes with a blunted upper tail (heavier weights). Mean oocyte or egg mass was compared with mean oocyte or egg diameter to determine whether or not the latter measurement adequately demonstrates change in size among stages due to yolk deposition. Mean weight of developing eggs increased significantly between mature-oocyte and ripening-oocyte stages. Within-female and within-stage variances decreased significantly between stages, and skew was nonsignificant for all stages, which showed there was a "catch-up" and supported Hypothesis 3. Diameters of oocytes and ova increased significantly between successive stages of development. Correlations between mean diameter and mean weight of oocytes and eggs decreased successively between stages, and the difference in correlation coefficients between mature-oocyte and ripe-egg stages was significant. Based on these data, we propose standard methods for the study of propagule size in darters. Our results may be broadly applicable to other taxa of fishes. C1 USA,WATERWAYS EXPT STN,VICKSBURG,MS 39180. TULANE UNIV,DEPT PSYCHOL,NEW ORLEANS,LA 70118. RP HEINS, DC (reprint author), TULANE UNIV,DEPT ECOL EVOLUT & ORGANISMAL BIOL,NEW ORLEANS,LA 70118, USA. NR 18 TC 40 Z9 40 U1 0 U2 0 PU AMER SOC ICHTHYOLOGISTS HERPETOLOGISTS BUSINESS OFFICE PI CARBONDALE PA SOUTHERN ILLINOIS UNIV, DEPT ZOOLOGY, CARBONDALE, IL 62901-6501 SN 0045-8511 J9 COPEIA JI Copeia PD MAY 1 PY 1992 IS 2 BP 404 EP 412 DI 10.2307/1446200 PG 9 WC Zoology SC Zoology GA HT728 UT WOS:A1992HT72800012 ER PT J AU DIERSING, VE SHAW, RB TAZIK, DJ AF DIERSING, VE SHAW, RB TAZIK, DJ TI US ARMY LAND CONDITION-TREND ANALYSIS (LCTA) PROGRAM SO ENVIRONMENTAL MANAGEMENT LA English DT Article DE LAND CONDITION-TREND ANALYSIS; LCTA; MILITARY TRAINING; METHODS; INVENTORY ID CANYON MANEUVER SITE; SOIL LOSS EQUATION; COLORADO AB The US Army Land Condition-Trend Analysis (LCTA) program is a standardized method of data collection, analysis, and reporting designed to meet multiple goals and objectives. The method utilizes vascular plant inventories, permanent field plot data, and wildlife inventories. Vascular plant inventories are used for environmental documentation, training of personnel, species identification during LCTA implementation, and as a survey for state and federal endangered or threatened species. The permanent field plot data documents the vegetational, edaphic, topographic, and disturbance characteristics of the installation. Inventory plots are allocated in a stratified random fashion across the installation utilizing a geographic information system that integrates satellite imagery and soil survey information. Ground cover, canopy cover. woody plant density, slope length, slope gradient, soil information, and disturbance data are collected at each plot. Plot data are used to: (1) describe plant communities, (2) characterize wildlife and threatened and endangered species habitat, (3) document amount and kind of military and nonmilitary disturbance, (4) determine the impact of military training on vegetation and soil resources, (5) estimate soil erosion potential, (6) classify land as to the kind and amount of use it can support, (7) determine allowable use estimates for tracked vehicle training, (8) document concealment resources, (9) identify lands that require restoration and evaluate the effectiveness of restorative techniques, and (10) evaluate potential acquisition Property. Wildlife inventories survey small and midsize mammals, birds, bats, amphibians, and reptiles. Data from these surveys can be used for environmental documentation, to identify state and federal endangered and threatened species, and to evaluate the impact Of military activities on wildlife populations. Short- and long-term monitoring of permanent field plots is used to evaluate and adjust land management decisions. C1 COLORADO STATE UNIV,DEPT RANGE SCI,FT COLLINS,CO 80523. USA,CORPS ENGINEERS,ENGN & HOUSING SUPPORT CTR,FT BELVOIR,VA 22060. USA,CONSTRUCT ENGN RES LAB,CHAMPAIGN,IL 61824. NR 47 TC 52 Z9 57 U1 1 U2 8 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0364-152X J9 ENVIRON MANAGE JI Environ. Manage. PD MAY-JUN PY 1992 VL 16 IS 3 BP 405 EP 414 DI 10.1007/BF02400080 PG 10 WC Environmental Sciences SC Environmental Sciences & Ecology GA HP847 UT WOS:A1992HP84700015 ER PT J AU LARUSSA, VF GRIFFIN, JD KESSLER, SW CUTTING, MA KNIGHT, RD BLATTLER, WA LAMBERT, JM WRIGHT, DG AF LARUSSA, VF GRIFFIN, JD KESSLER, SW CUTTING, MA KNIGHT, RD BLATTLER, WA LAMBERT, JM WRIGHT, DG TI EFFECTS OF ANTI-CD33 BLOCKED RICIN IMMUNOTOXIN ON THE CAPACITY OF CD34+ HUMAN MARROW-CELLS TO ESTABLISH INVITRO HEMATOPOIESIS IN LONG-TERM MARROW CULTURES SO EXPERIMENTAL HEMATOLOGY LA English DT Article DE ANTI-CD33 IMMUNOTOXIN; HEMATOPOIESIS; CD34; MARROW TRANSPLANTATION; LONG-TERM MARROW CULTURES ID COLONY-FORMING CELLS; HUMAN-BONE-MARROW; PROGENITOR CELLS; LIMITING DILUTION; PRECURSORS; EXPRESSION; UNIPOTENT; ANTIGEN; MOUSE AB Human marrow cells that express the CD34 antigen but lack CD33 are able to initiate sustained, multilineage in vitro hematopoiesis in long-term Dexter cultures and are believed to include the primitive stem cells responsible for effecting long-term hematopoietic reconstitution in vivo following marrow transplantation. In studies described in this report we investigated the effects of a novel anti-CD33 immunotoxin on the clonogenic potential of normal human CD34+ marrow cells and on the ability of these cells to initiate hematopoiesis in two-stage Dexter cultures (long-term marrow cultures, LTMC). This immunotoxin (anti-CD33-bR), shown previously to kill both clonogenic myelogenous leukemia cells and normal mature myeloid progenitor cells (granulocyte-macrophage colony-forming units, CFU-GM), consists of an anti-CD33 monoclonal antibody conjugated to purified ricin that has been modified by blocking the carbohydrate binding domains of the ricin B-chain to eliminate nonspecific binding. For our studies, normal CD34+ human marrow cells were isolated from the light-density (< 1.070 g/ml) cells of aspirated marrow by positive selection with immunomagnetic beads linked to the monoclonal antibody K6.1. These cell isolates were highly enriched with both multipotential and lineage-restricted clonogenic, hematopoietic progenitors (mixed lineage colony-forming units, CFU-Mix; CFU-GM; and erythroid burst-forming units, BFU-E) which constituted greater-than-or-equal-to 20% of the cells. Recovery of clonogenic progenitors from these CD34+ cell preparations, following treatment with anti-CD33-bR (10 nM), was reduced by greater-than-or-equal-to 85% for CFU-GM and 20%-40% for CFU-Mix and BFU-E. However, the capacity of these cells to initiate hematopoietic LTMC was preserved. Indeed, the production of high proliferative potential (HPP) CFU-GM, BFU-E, and CFU-Mix in cultures seeded with 10(5) anti-CD33-bR-treated CD34+ marrow cells was substantially greater than that observed in LTMC seeded with equivalent numbers of untreated CD34+ cells. Moreover, concentrations of long-term culture initiating cells in CD34+ cell isolates, quantified by a limiting dilution technique, were found to be increased following anti-CD33-bR treatment. These findings support the potential usefulness of anti-CD33-bR for in vitro marrow purging or in vivo treatment to eliminate CD33+ leukemic clones, while sparing normal CD34+/CD33- stem cells that support normal hematopoiesis and hematopoietic reconstitution in vivo. C1 USN,RES INST,IMMUNE CELL BIOL PROGRAM,BETHESDA,MD 20814. IMMUNOGEN INC,CAMBRIDGE,MA. HARVARD UNIV,SCH MED,DANA FARBER CANC INST,DIV TUMOR IMMUNOL,BOSTON,MA 02115. RP LARUSSA, VF (reprint author), WALTER REED ARMY MED CTR,DIV MED,DEPT HEMATOL,WASHINGTON,DC 20307, USA. NR 30 TC 29 Z9 29 U1 0 U2 0 PU CARDEN JENNINGS PUBL CO LTD PI CHARLOTTESVILLE PA BLAKE CTR, STE 200, 1224 W MAIN ST, CHARLOTTESVILLE, VA 22903 SN 0301-472X J9 EXP HEMATOL JI Exp. Hematol. PD MAY PY 1992 VL 20 IS 4 BP 442 EP 448 PG 7 WC Hematology; Medicine, Research & Experimental SC Hematology; Research & Experimental Medicine GA HT028 UT WOS:A1992HT02800013 PM 1373688 ER PT J AU WILLIAMSON, DM GRAVANI, RB LAWLESS, HT AF WILLIAMSON, DM GRAVANI, RB LAWLESS, HT TI CORRELATING FOOD SAFETY KNOWLEDGE WITH HOME FOOD-PREPARATION PRACTICES SO FOOD TECHNOLOGY LA English DT Article; Proceedings Paper CT SYMP ON FOOD SAFETY EDUCATIONAL OUTREACH, AT THE 1991 ANNUAL MEETING OF THE INST OF FOOD TECHNOLOGISTS CY JUN 01-05, 1991 CL DALLAS, TX SP INST FOOD TECHNOLOGISTS C1 CORNELL UNIV,DEPT FOOD SCI,STOCKING HALL,ITHACA,NY 14853. USA,QUARTERMASTER CORPS,FT LEE,VA 23801. NR 20 TC 76 Z9 77 U1 0 U2 2 PU INST FOOD TECHNOLOGISTS PI CHICAGO PA SUITE 300 221 N LASALLE ST, CHICAGO, IL 60601-1291 SN 0015-6639 J9 FOOD TECHNOL-CHICAGO JI Food Technol. PD MAY PY 1992 VL 46 IS 5 BP 94 EP & PG 0 WC Food Science & Technology SC Food Science & Technology GA HU753 UT WOS:A1992HU75300005 ER PT J AU MONAHAN, DW STARNES, EC PARKER, AL AF MONAHAN, DW STARNES, EC PARKER, AL TI COLONIC STRICTURES IN A PATIENT ON LONG-TERM NONSTEROIDAL ANTIINFLAMMATORY DRUGS SO GASTROINTESTINAL ENDOSCOPY LA English DT Article ID BOWEL-DISEASE; INDOMETHACIN; ACID C1 BROOKE ARMY MED CTR,DEPT MED,GASTROENTEROL SERV,FT SAM HOUSTON,TX 78234. NR 17 TC 53 Z9 53 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0016-5107 J9 GASTROINTEST ENDOSC JI Gastrointest. Endosc. PD MAY-JUN PY 1992 VL 38 IS 3 BP 385 EP 388 DI 10.1016/S0016-5107(92)70442-8 PG 4 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA HX668 UT WOS:A1992HX66800022 PM 1607098 ER PT J AU CRANSTON, J AF CRANSTON, J TI HITLER STATE ARCHITECTURE - THE IMPACT OF CLASSICAL ANTIQUITY - SCOBIE,A SO GERMAN STUDIES REVIEW LA English DT Book Review RP CRANSTON, J (reprint author), US ARMY ARMOR CTR,FT KNOX,KY, USA. NR 1 TC 0 Z9 0 U1 1 U2 1 PU ARIZ STATE UNIV PI TEMPE PA WEST ASSN GERMAN STUD, TEMPE, AZ 85287-4205 SN 0149-7952 J9 GER STUD REV JI Ger. Stud. Rev. PD MAY PY 1992 VL 15 IS 2 BP 406 EP 407 DI 10.2307/1431203 PG 2 WC Area Studies; Humanities, Multidisciplinary SC Area Studies; Arts & Humanities - Other Topics GA JR699 UT WOS:A1992JR69900042 ER PT J AU CHATHAMSHOWALTER, PE AF CHATHAMSHOWALTER, PE TI MEDICAL DISORDERS AMONG YOUNG ACUTELY ILL PSYCHIATRIC-PATIENTS IN A MILITARY HOSPITAL SO HOSPITAL AND COMMUNITY PSYCHIATRY LA English DT Note ID ILLNESS C1 IRWIN ARMY COMMUNITY HOSP,PSYCHIAT SECT,FT RILEY,KS. RP CHATHAMSHOWALTER, PE (reprint author), WALTER REED ARMY MED CTR,PSYCHIAT CONSULTAT HASISON SERV,WASHINGTON,DC 20307, USA. NR 7 TC 3 Z9 3 U1 0 U2 0 PU AMER PSYCHIATRIC ASSOCIATION PI WASHINGTON PA 1400 K ST NW, WASHINGTON, DC 20005 SN 0022-1597 J9 HOSP COMMUNITY PSYCH PD MAY PY 1992 VL 43 IS 5 BP 511 EP 514 PG 4 WC Public, Environmental & Occupational Health; Psychiatry SC Public, Environmental & Occupational Health; Psychiatry GA HQ847 UT WOS:A1992HQ84700019 PM 1587520 ER PT J AU TORRIERI, DJ AF TORRIERI, DJ TI PERFORMANCE OF DIRECT-SEQUENCE SYSTEMS WITH LONG PSEUDONOISE SEQUENCES SO IEEE JOURNAL ON SELECTED AREAS IN COMMUNICATIONS LA English DT Article ID SPREAD-SPECTRUM COMMUNICATIONS; RANDOM SIGNATURE SEQUENCES; ERROR-PROBABILITY; APPROXIMATIONS AB A performance analysis of direct-sequence systems with long pseudonoise sequences is presented. The major focus of the paper is to assess the symbol error probability in the presence of multiple-access interference, but other types of interference are also considered for completeness. Both binary and quaternary spreading waveforms are treated. The analysis, which uses a nonstandard Gaussian approximation, makes transparent the answers to a number of technical issues. Approximate error probabilities that are relatively simple computationally are derived. The approximations are accurate to within at least one decibel and, more typically, a few tenths of a decibel. RP TORRIERI, DJ (reprint author), USA,ADELPHI,MD 20783, USA. NR 11 TC 62 Z9 68 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0733-8716 J9 IEEE J SEL AREA COMM JI IEEE J. Sel. Areas Commun. PD MAY PY 1992 VL 10 IS 4 BP 770 EP 781 DI 10.1109/49.136072 PG 12 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA HR464 UT WOS:A1992HR46400013 ER PT J AU LU, ST BROWN, DO JOHNSON, CE MATHUR, SP ELSON, EC AF LU, ST BROWN, DO JOHNSON, CE MATHUR, SP ELSON, EC TI ABNORMAL CARDIOVASCULAR-RESPONSES INDUCED BY LOCALIZED HIGH-POWER MICROWAVE EXPOSURE SO IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING LA English DT Article ID RADIATION; HEALTH; HUMANS AB A hypothesis of microwave-induced circulatory under perfusion was tested in ketamine anesthetized rats whose heart rate, mean arterial pressure, pulse pressure, respiration rate, and body temperatures were monitored continuously. Fifty-eight ventral head and neck exposures in a waveguide consisted of sham-exposure and exposure to continuous wave (CW) and pulsed 1.25 GHz microwaves for 5 min. The 0.5 Hz (10-mu-s, 2 W average) and 16 Hz (1-mu-s, 6.4 W average) pulse-modulated microwaves were delivered at 400 kW peak power. The CW microwaves were 2 and 6.4 W. The average specific absorption rate was 4.75 W/kg per watt transmitted in the brain and 17.15 W/kg per watt transmitted in the neck. Respiration rate and mean arterial pressure were not altered. Changes in heart rate and pulse pressure were observed in rats exposed to higher power (16 Hz pulses and 6.4 W CW) but not to the lower average power microwaves (0.5 Hz pulses and 2 W CW). Depression of pulse pressure, an indication of a decrease in stroke volume, and increased (tachycardia) or decreased (bradycardia) heart rate were noted in presence of whole-body hyperthermia. The cardiac output of those animals exposed to higher average power microwaves was considered to be below normal as hypothesized. Decreased cardiac output and normal mean arterial pressure resulted in an increase in the total peripheral resistance which was contrary to the anticipated thermal response of animals. C1 ERC BIOSERV CORP,GAITHERSBURG,MD 20879. WALTER REED ARMY MED CTR,DEPT MICROWAVE RES,DIV NEUROPSYCHIAT,WASHINGTON,DC 20307. NR 31 TC 2 Z9 2 U1 0 U2 4 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9294 J9 IEEE T BIO-MED ENG JI IEEE Trans. Biomed. Eng. PD MAY PY 1992 VL 39 IS 5 BP 484 EP 492 DI 10.1109/10.135542 PG 9 WC Engineering, Biomedical SC Engineering GA HR461 UT WOS:A1992HR46100007 PM 1388133 ER PT J AU GUENTHER, BD VANDERLUGT, A AF GUENTHER, BD VANDERLUGT, A TI INTERFERENCE AND FRESNEL DIFFRACTION SO IEEE TRANSACTIONS ON EDUCATION LA English DT Article AB A surprising number of traditional topics, such as the Rayleigh resolution criterion, spatial filtering, bandlimited signals, the sampling theorem, phase contrast microscopy, and white light holography can be explained using simple interference theory. These basic results are then easily extended to the N-source case to introduce diffraction theory, and facilitates the teaching of the elements of modern optics to junior- and senior-level students. C1 DUKE UNIV,DURHAM,NC 27706. N CAROLINA STATE UNIV,RALEIGH,NC 27695. RP GUENTHER, BD (reprint author), USA,RES OFF,RES TRIANGLE PK,NC, USA. NR 13 TC 1 Z9 1 U1 1 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9359 J9 IEEE T EDUC JI IEEE Trans. Educ. PD MAY PY 1992 VL 35 IS 2 BP 126 EP 132 DI 10.1109/13.135577 PG 7 WC Education, Scientific Disciplines; Engineering, Electrical & Electronic SC Education & Educational Research; Engineering GA HU436 UT WOS:A1992HU43600007 ER PT J AU KOH, G AF KOH, G TI EFFECT OF WIND ON FM-CW RADAR BACKSCATTER FROM A WET SNOWCOVER SO IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING LA English DT Note ID PASSIVE MICROWAVE RESPONSE; SNOW PARAMETERS AB The most important factor affecting the microwave properties of a snowcover is the liquid water content (snow wetness). An FM-CW (26.5-40 GHz) radar has been used to investigate the influence of snow wetness on the magnitude of radar backscatter from a snowcover. The radar backscatter measurements from a wet snowcover on a windy day suggest that evaporative cooling due to the wind may reduce the amount of liquid water at the snowcover surface. RP KOH, G (reprint author), USA,COLD REG RES & ENGN LAB,HANOVER,NH 03755, USA. NR 9 TC 5 Z9 5 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0196-2892 J9 IEEE T GEOSCI REMOTE JI IEEE Trans. Geosci. Remote Sensing PD MAY PY 1992 VL 30 IS 3 BP 619 EP 621 DI 10.1109/36.142942 PG 3 WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote Sensing; Imaging Science & Photographic Technology SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science & Photographic Technology GA JA318 UT WOS:A1992JA31800022 ER PT J AU HELD, TK TRAUTMANN, M MIELKE, MEA NEUDECK, H CRYZ, SJ CROSS, AS AF HELD, TK TRAUTMANN, M MIELKE, MEA NEUDECK, H CRYZ, SJ CROSS, AS TI MONOCLONAL-ANTIBODY AGAINST KLEBSIELLA CAPSULAR POLYSACCHARIDE REDUCES SEVERITY AND HEMATOGENIC SPREAD OF EXPERIMENTAL KLEBSIELLA-PNEUMONIAE PNEUMONIA SO INFECTION AND IMMUNITY LA English DT Article ID PSEUDOMONAS-AERUGINOSA PNEUMONIA; EXTRACELLULAR TOXIC COMPLEX; INFECTIONS; RESISTANCE; ANTIGENS; CEPHALOSPORINS; IMMUNIZATION; BACTEREMIA; CHALLENGE; EPISODES AB Klebsiella pneumoniae is an important nosocomial pathogen causing severe pulmonary infections. The majority of clinical Klebsiella isolates produce a high-molecular-weight capsular polysaccharide (CPS) which is one of the dominant virulence factors. In the present study, we examined the potency of a murine immunoglobulin M monoclonal antibody (MAb) with specificity to Klebsiella type 2 CPS to protect rats against experimental Klebsiella pneumonia. The MAb did not prevent the invasion of virulent bacteria into the interalveolar space. However, the resolution of infection was accelerated in MAb-treated animals. This was demonstrated by (i) less severe weight loss and (ii) markedly reduced inflammatory reactions in the lung. The elimination of bacteria was significantly increased not only in the lungs but also in the livers of antibody-treated rats. This was reflected by reduced levels of circulating, soluble CPS and MAb-bound CPS. A mixture of human MAbs with specificity to CPS of clinically important Klebsiella serotypes may prove to be a useful tool for the prevention or supportive treatment of Klebsiella pneumonia. C1 FREE UNIV BERLIN,KLINIKUM RUDOLF VIRCHOW CHARLOTTENBURG,DEPT INFECT DIS,W-1000 BERLIN,GERMANY. FREE UNIV BERLIN,KLINIKUM RUDOLF VIRCHOW CHARLOTTENBURG,DEPT MICROBIOL,W-1000 BERLIN,GERMANY. FREE UNIV BERLIN,KLINIKUM RUDOLF VIRCHOW CHARLOTTENBURG,DEPT PATHOL,W-1000 BERLIN,GERMANY. SWISS SERUM & VACCINE INST,CH-3001 BERN,SWITZERLAND. WALTER REED ARMY MED CTR,DEPT BACTERIAL DIS,WASHINGTON,DC 20307. NR 39 TC 23 Z9 23 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD MAY PY 1992 VL 60 IS 5 BP 1771 EP 1778 PG 8 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA HR065 UT WOS:A1992HR06500008 PM 1563764 ER PT J AU FRIES, LF GORDON, DM SCHNEIDER, I BEIER, JC LONG, GW GROSS, M QUE, JU CRYZ, SJ SADOFF, JC AF FRIES, LF GORDON, DM SCHNEIDER, I BEIER, JC LONG, GW GROSS, M QUE, JU CRYZ, SJ SADOFF, JC TI SAFETY, IMMUNOGENICITY, AND EFFICACY OF A PLASMODIUM-FALCIPARUM VACCINE COMPRISING A CIRCUMSPOROZOITE PROTEIN REPEAT REGION PEPTIDE CONJUGATED TO PSEUDOMONAS-AERUGINOSA TOXIN-A SO INFECTION AND IMMUNITY LA English DT Article ID SPOROZOITE VACCINE; MALARIA AB Twenty-one malaria-naive volunteers were immunized with a vaccine consisting of a 22-kDa recombinant peptide (R32LR), derived from the repeat region of Plasmodium falciparum circumsporozoite (CS) protein, covalently coupled to detoxified Pseudomonas aeruginosa toxin A. Nineteen volunteers received a second dose of vaccine at 8 weeks, and eighteen received a third dose at 8 to 12 months. The vaccine was well tolerated, with only one volunteer developing local discomfort and induration at the site of injection which limited function for 48 h. The geometric mean anti-CS immunoglobulin G antibody concentration 2 weeks after the second dose of vaccine was 10.6-mu-g/ml (standard deviation = 3.0-mu-g/ml). Eleven volunteers (52%) developed anti-CS antibody levels of > 9.8-mu-g/ml, the level measured in the one volunteer protected against P. falciparum challenge after immunization with the alum-adjuvanted recombinant protein R32tet32 in a prior study. Three separate experimental challenges were conducted with 10 volunteers 2 to 4 weeks after the third dose of vaccine. The four best responders, on the basis of antibody levels (6 to 26-mu-g/ml), were challenged with two infected-mosquito bites, but only one of four immunized volunteers and one of three malaria-naive controls became parasitemic. In a second challenge study using five infected-mosquito bites as the challenge dose, three of three malaria-naive control volunteers and two of three immunized volunteers developed malaria. The third vaccinee was apparently completely protected. In the third and last challenge, three of three controls and five of five vaccinees became infected. Sera obtained on the days of challenge inhibited sporozoite invasion of hepatocytes variably in vitro (range, 45 to 90% inhibition), but the degree of inhibition did not correlate with protection. Although antibody against the CS repeat region may protect some individuals against experimental challenge, this protection cannot be predicted from antibody levels by current in vitro assays. The functionality and fine specificity of anti-CS antibody are probably critical determinants. C1 JOHNS HOPKINS UNIV,DEPT IMMUNOL & INFECT DIS,BALTIMORE,MD 21205. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. SMITHKLINE BEECHAM,PHILADELPHIA,PA 19101. SWISS SERUM & VACCINE INST,BERN,SWITZERLAND. RP FRIES, LF (reprint author), JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,CTR IMMUNIZAT RES,BALTIMORE,MD 21205, USA. FU NIAID NIH HHS [R22-AI-29000] NR 15 TC 48 Z9 49 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD MAY PY 1992 VL 60 IS 5 BP 1834 EP 1839 PG 6 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA HR065 UT WOS:A1992HR06500017 PM 1563771 ER PT J AU DEVENISH, J BROWN, JE ROSENDAL, S AF DEVENISH, J BROWN, JE ROSENDAL, S TI ASSOCIATION OF THE RTX PROTEINS OF ACTINOBACILLUS-PLEUROPNEUMONIAE WITH HEMOLYTIC, CAMP, AND NEUTROPHIL-CYTOTOXIC ACTIVITIES SO INFECTION AND IMMUNITY LA English DT Note ID HEAT-LABILE HEMOLYSIN; HEMOPHILUS-PLEUROPNEUMONIAE; ESCHERICHIA-COLI; SWINE; IDENTIFICATION; STRAINS; SEROTYPE-1; CLONING; GENE AB The immunoglobulin G from a monospecific rabbit antiserum to the 110-kDa RTX hemolysin of Actinobacillus pleuropneumoniae serotype 1 was used to determine that the related RTX proteins in isolates from serotypes 2 to 12 were also responsible for the hemolytic, CAMP, and neutrophil-cytotoxic activities produced by this bacterium. These proteins share common neutralizing epitopes. C1 UNIV GUELPH,DEPT VET MICROBIOL & IMMUNOL,GUELPH N1G 2W1,ONTARIO,CANADA. RP DEVENISH, J (reprint author), USA,MED RES INST INFECT DIS,DIV TOXICOL,FT DETRICK,FREDERICK,MD 21702, USA. NR 39 TC 12 Z9 13 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD MAY PY 1992 VL 60 IS 5 BP 2139 EP 2142 PG 4 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA HR065 UT WOS:A1992HR06500066 PM 1314227 ER PT J AU CHANH, TC KENNEDY, RC HEWETSON, JF AF CHANH, TC KENNEDY, RC HEWETSON, JF TI ANTIIDIOTYPE VACCINES IN TOXICOLOGY SO INTERNATIONAL JOURNAL OF CLINICAL & LABORATORY RESEARCH LA English DT Review DE ANTIIDIOTYPE ANTIBODY VACCINES; T-2 MYCOTOXIN; SAXITOXIN; TETRODOTOXIN; RICIN ID HUMAN IMMUNODEFICIENCY VIRUS; TRICHOTHECENE MYCOTOXIN T-2; HERPES-SIMPLEX VIRUS; INTERNAL IMAGE; MONOCLONAL-ANTIBODIES; IMMUNE-RESPONSE; TUMOR-IMMUNITY; MICE; INDUCTION; IMMUNIZATION AB The majority of naturally occurring biological and chemical toxins are highly lethal, nonproteinaceous, low molecular weight substances which exert their toxicity through a variety of mechanisms. Their relative small size and extreme in vivo toxicity have hampered the development of protective vaccines. We have investigated the feasibility of anti-idiotype-based vaccines which utilize antibodies for inducing a systemic and protective immunity against the in vivo toxicity of some of these toxic substances. A murine IgG1 monoclonal anti-T-2 mycotoxin antibody protective against mycotoxin toxicity was generated. This antibody was used to produce a second generation monoclonal anti-idiotype antibody which was capable of serologically mimicking the tertiary conformation of the nominal antigen, i.e., T-2 mycotoxin. Administration of the monoclonal anti-idiotype antibody to mice induced a circulating and protective antibody response against the in vitro and in vivo toxicity of T-2 mycotoxin. Antibody-based vaccines may represent the only safe and effective strategy for the design of protective vaccines against small nonproteinaceous toxic compounds whose extreme toxicity prevents their use as safe immunogens. The potential of antibody-based vaccines for producing protective immunity against low molecular weight chemical and biological toxins is discussed. C1 SW FDN BIOMED RES,CTR AIDS RES,SAN ANTONIO,TX 78284. USA,MED RES INST INFECT DIS,FREDERICK,MD 21701. RP CHANH, TC (reprint author), SW FDN BIOMED RES,DEPT VIROL & IMMUNOL,POB 28147,SAN ANTONIO,TX 78284, USA. NR 60 TC 15 Z9 15 U1 0 U2 1 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0940-5437 J9 INT J CLIN LAB RES JI Int. J. Clin. Lab. Res. PD MAY PY 1992 VL 22 IS 1 BP 28 EP 35 DI 10.1007/BF02591390 PG 8 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA HW201 UT WOS:A1992HW20100006 PM 1633317 ER PT J AU COURY, BG WEILAND, MZ CUQLOCKKNOPP, VG AF COURY, BG WEILAND, MZ CUQLOCKKNOPP, VG TI PROBING THE MENTAL MODELS OF SYSTEM STATE CATEGORIES WITH MULTIDIMENSIONAL-SCALING SO INTERNATIONAL JOURNAL OF MAN-MACHINE STUDIES LA English DT Article ID DISPLAYS C1 CHI SYST,SPRING HOUSE,PA 19477. USA,HUMAN ENGN LAB,DIV BEHAV RES,ABERDEEN PROVING GROUND,MD 21005. RP COURY, BG (reprint author), UNIV MASSACHUSETTS,DEPT IND ENGN & OPERAT RES,114 MARSTON HALL,AMHERST,MA 01003, USA. NR 28 TC 6 Z9 6 U1 0 U2 2 PU ACADEMIC PRESS LTD PI LONDON PA 24-28 OVAL RD, LONDON, ENGLAND NW1 7DX SN 0020-7373 J9 INT J MAN MACH STUD PD MAY PY 1992 VL 36 IS 5 BP 673 EP 696 DI 10.1016/0020-7373(92)90036-K PG 24 WC Computer Science, Cybernetics; Ergonomics; Psychology SC Computer Science; Engineering; Psychology GA HU173 UT WOS:A1992HU17300002 ER PT J AU KRYZER, TC DERKAY, CS AF KRYZER, TC DERKAY, CS TI KAWASAKI-DISEASE - 5-YEAR EXPERIENCE AT CHILDRENS-NATIONAL-MEDICAL-CENTER SO INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY LA English DT Article DE MUCOCUTANEOUS LYMPH NODE SYNDROME; KAWASAKI DISEASE; CERVICAL ADENOPATHY; OTOLARYNGIC MANIFESTATION ID LYMPH-NODE SYNDROME AB Kawasaki Disease (KD) is an acute multisystem disease that predominately affects infants and children. Coronary artery aneurysms or ectasia may develop in 15-25% of children with the disease and may lead to myocardial infarction or sudden death. Head and neck manifestations are often the presenting symptoms, thus the otolaryngologist may be asked to evaluate a child early in the course of the disease. Otolaryngologists need to be familiar with the early symptoms of this disease so that prompt diagnosis may be made and appropriate therapy instituted. Recent therapeutic advances have been shown to be effective in reducing the prevalence of coronary artery abnormalities. The authors retrospectively reviewed cases of KD seen at Children's National Medical Center over a 5-year period. Sixty-nine cases were included in the reviews and all children exhibited head and neck manifestations upon admission. Our data and review of the relevant literature underscore the need for heightened awareness among our profession in regards to KD. C1 EASTERN VIRGINIA MED CTR,NORFOLK,VA. RP KRYZER, TC (reprint author), WALTER REED ARMY MED CTR,OTOLARYNGOL HEAD & NECK SURG,WASHINGTON,DC 20307, USA. NR 18 TC 7 Z9 8 U1 0 U2 0 PU ELSEVIER SCI IRELAND LTD PI CLARE PA CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE, IRELAND SN 0165-5876 J9 INT J PEDIATR OTORHI JI Int. J. Pediatr. Otorhinolaryngol. PD MAY PY 1992 VL 23 IS 3 BP 211 EP 220 DI 10.1016/0165-5876(92)90102-U PG 10 WC Otorhinolaryngology; Pediatrics SC Otorhinolaryngology; Pediatrics GA HV834 UT WOS:A1992HV83400002 PM 1592557 ER PT J AU MCCUTCHAN, FE UNGAR, BLP HEGERICH, P ROBERTS, CR FOWLER, AK HIRA, SK PERINE, PL BURKE, DS AF MCCUTCHAN, FE UNGAR, BLP HEGERICH, P ROBERTS, CR FOWLER, AK HIRA, SK PERINE, PL BURKE, DS TI GENETIC-ANALYSIS OF HIV-1 ISOLATES FROM ZAMBIA AND AN EXPANDED PHYLOGENETIC TREE FOR HIV-1 SO JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY LA English DT Article DE ZAMBIAN HIV-1 ISOLATES; PCR FINGERPRINTING; GAG GENE SEQUENCES; HIV-1 PHYLOGENY ID NUCLEOTIDE-SEQUENCE ANALYSIS; HUMAN-IMMUNODEFICIENCY-VIRUS; ENVELOPE GENE; DOMAINS; STRAIN AB Geographic variation in the HIV-1 virus is extensive but incompletely documented. We herein report the first genetic characterization of HIV-1 isolates from Zambia. The genomic region encoding the GAG polyprotein has been compared among 22 Zambian isolates and 14 North American isolates using a combination of polymerase chain reaction (PCR) and DNA sequencing methods. The Zambian isolates were similar to one another but distinct from other HIV-1 isolates. They exhibited a characteristic PCR "fingerprint" wherein certain primer combinations were unable to amplify because of mispairing. The sequence of the complete gag gene of three isolates from Zambia has been determined. and phylogenetic tree analysis placed them in a branch distinct from other African isolates and North American isolates. The PCR procedure used here may be widely applicable for genetic characterization of HIV-1. C1 WALTER REED ARMY MED CTR,DIV RETROVIROL,WASHINGTON,DC 20307. SRA LABS INC,ROCKVILLE,MD. UNIV TEACHING HOSP LUSAKA,LUSAKA,ZAMBIA. UNIFORMED SERV UNIV HLTH SCI,DIV TROP PUBL HLTH,BETHESDA,MD 20814. RP MCCUTCHAN, FE (reprint author), HENRY M JACKSON FDN ADVANCEMENT MIL MED,RES LAB,1500 E GUDE DR,ROCKVILLE,MD 20850, USA. NR 16 TC 41 Z9 41 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 1077-9450 J9 J ACQ IMMUN DEF SYND JI J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. PD MAY PY 1992 VL 5 IS 5 BP 441 EP 449 PG 9 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA HP068 UT WOS:A1992HP06800002 PM 1560340 ER PT J AU CARR, LW CHANDRASEKHARA, MS AF CARR, LW CHANDRASEKHARA, MS TI DESIGN AND DEVELOPMENT OF A COMPRESSIBLE DYNAMIC STALL FACILITY SO JOURNAL OF AIRCRAFT LA English DT Article AB A dynamic stall facility offering a unique new capability for studies of compressibility effects on dynamic stall is described. This facility features complete visual access by mounting the test airfoil between optical quality glass windows that are rotated in unison to produce the oscillating airfoil motion associated with helicopter rotor dynamic stall. By using the density gradients associated with the rapidly changing dynamic stall flowfield, this facility permits simultaneous detailed investigation of the flow on the surface as well as in the flowfield surrounding airfoils experiencing dynamic stall. RP CARR, LW (reprint author), USA,AVSCOM,MOFFETT FIELD,CA 94035, USA. NR 0 TC 12 Z9 13 U1 0 U2 0 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091 SN 0021-8669 J9 J AIRCRAFT JI J. Aircr. PD MAY-JUN PY 1992 VL 29 IS 3 BP 314 EP 318 DI 10.2514/3.46163 PG 5 WC Engineering, Aerospace SC Engineering GA HX252 UT WOS:A1992HX25200005 ER PT J AU BYRD, GD PAULE, RC SANDER, LC SNIEGOSKI, LT WHITE, E BAUSUM, HT AF BYRD, GD PAULE, RC SANDER, LC SNIEGOSKI, LT WHITE, E BAUSUM, HT TI DETERMINATION OF 3-QUINUCLIDINYL BENZILATE (QNB) AND ITS MAJOR METABOLITES IN URINE BY ISOTOPE-DILUTION GAS-CHROMATOGRAPHY MASS-SPECTROMETRY SO JOURNAL OF ANALYTICAL TOXICOLOGY LA English DT Article C1 NATL INST STAND & TECHNOL,CTR ANALYT CHEM,GAITHERSBURG,MD 20899. USA,BIOMED RES & DEV LAB,FREDERICK,MD 21702. NR 12 TC 3 Z9 3 U1 4 U2 7 PU PRESTON PUBLICATIONS INC PI NILES PA 7800 MERRIMAC AVE PO BOX 48312, NILES, IL 60648 SN 0146-4760 J9 J ANAL TOXICOL JI J. Anal. Toxicol. PD MAY-JUN PY 1992 VL 16 IS 3 BP 182 EP 187 PG 6 WC Chemistry, Analytical; Toxicology SC Chemistry; Toxicology GA HW175 UT WOS:A1992HW17500011 PM 1522714 ER PT J AU ZAVADA, JM WEISS, BL BRADLEY, IV THEYS, B CHEVALLIER, J RAHBI, R ADDINALL, R NEWMAN, RC JENKINSON, HA AF ZAVADA, JM WEISS, BL BRADLEY, IV THEYS, B CHEVALLIER, J RAHBI, R ADDINALL, R NEWMAN, RC JENKINSON, HA TI OPTICAL WAVE-GUIDES FORMED BY DEUTERIUM PASSIVATION OF ACCEPTORS IN SI DOPED P-TYPE GAAS EPILAYERS SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID ATOMIC-HYDROGEN; NEUTRALIZATION AB We report on the use of plasma hydrogenation of Si doped, p-type GaAs crystalline samples to form infrared waveguides through acceptor passivation. Epilayers grown by liquid phase epitaxy were exposed to a deuterium plasma for ninety minutes at three different temperatures. Secondary-ion mass spectrometry (SIMS) analysis indicated that the deuterium concentrations in the crystals after plasma exposure were nearly equal to the acceptor level and extended to depths between 2.0 and 4.0-mu-m. Reflectivity measurements showed that the epilayers had passivated regions whose thicknesses corresponded to those determined by SIMS analysis. Laser coupling experiments at 1.15-mu-m showed optical waveguiding in each sample and lowest propagation losses were on the order of 35 dB/cm. At a wavelength of 1.523-mu-m, only the sample processed at the highest temperature exhibited laser guiding and losses were considerably higher. C1 UNIV SURREY,GUILDFORD GU2 5XH,SURREY,ENGLAND. CNRS,PHYS SOLIDES LAB,F-92195 MEUDON,FRANCE. UNIV LONDON IMPERIAL COLL SCI TECHNOL & MED,INTERDISCIPLINARY RES CTR SEMICOND MAT,LONDON SW7 2BZ,ENGLAND. USA,CTR ARMAMENT RES DEV & ENGN,DOVER,NJ 07801. RP ZAVADA, JM (reprint author), USA,RES OFF,RES TRIANGLE PK,NC 27709, USA. RI Schaff, William/B-5839-2009 NR 13 TC 5 Z9 5 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD MAY 1 PY 1992 VL 71 IS 9 BP 4151 EP 4155 DI 10.1063/1.350849 PG 5 WC Physics, Applied SC Physics GA HR455 UT WOS:A1992HR45500008 ER PT J AU PAMULAPATI, J BHATTACHARYA, P TOBER, RL LOEHR, JP SINGH, J AF PAMULAPATI, J BHATTACHARYA, P TOBER, RL LOEHR, JP SINGH, J TI CHARACTERIZATION OF HIGH-QUALITY PSEUDOMORPHIC INGAAS/GAAS QUANTUM-WELLS BY LUMINESCENCE AND REFLECTANCE TECHNIQUES SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID SUPERLATTICES; STRAIN AB Reflectance and photoluminescence spectroscopy have been used to study the optical properties of high quality InxGa1-xAs/GaAs (0.13 less-than-or-equal-to x less-than-or-equal-to 0.30) single quantum wells. The results show strong agreement with the theoretical model used taking into account the strain potential. The agreement of the theoretical model, though, deviates from the experimental results for large values of excess strain in the well. For the case of the large strain (x = 0.30) the reflectance indicates the strain in the well is hydrostatic rather than biaxial. The relevance of this fact is discussed in relation to device performance. C1 USA,LAB COMMAND,HARRY DIAMOND LABS,ADELPHI,MD 20783. RP PAMULAPATI, J (reprint author), UNIV MICHIGAN,DEPT ELECT ENGN & COMP SCI,CTR HIGH FREQUENCY MICROELECTR,ANN ARBOR,MI 48109, USA. NR 15 TC 4 Z9 4 U1 0 U2 2 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD MAY 1 PY 1992 VL 71 IS 9 BP 4487 EP 4491 DI 10.1063/1.350793 PG 5 WC Physics, Applied SC Physics GA HR455 UT WOS:A1992HR45500059 ER PT J AU SHONNARD, KM JELINEK, JS BENEDIKT, RA KRANSDORF, MJ AF SHONNARD, KM JELINEK, JS BENEDIKT, RA KRANSDORF, MJ TI CT AND MR OF NEUROFIBROMATOSIS OF THE BLADDER SO JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY LA English DT Article DE NEUROFIBROMATOSIS; BLADDER, NEOPLASMS; COMPUTED TOMOGRAPHY; MAGNETIC RESONANCE IMAGING ID COMPUTED-TOMOGRAPHY; CHILDHOOD; PELVIS AB Neurofibromatosis of the genitourinary system is rare. We present the CT and MR findings of neurofibromas of the bladder in three patients with von Recklinghausen disease (neurofibromatosis, Type 1). In one case, genitourinary involvement was the primary presentation of the disease. Both CT and MR imaging revealed diffuse and nodular bladder wall involvement, along with pelvic sidewall and adjacent soft tissue abnormalities. The CT attenuation coefficients measured near soft tissue density. On T1-weighted spin echo MR images the tumors revealed signal intensity slightly greater than that of skeletal muscle. Neurofibromas showed markedly increased signal intensity on T2-weighted images relative to the surrounding soft tissues, with marked enhancement in two cases imaged following Gd-DTPA administration. Obstructive hydronephrosis was present in all cases, presumably due to neurofibromas involving the trigonal region. Pelvic sidewall tumors were visualized as rounded, nodular masses extending into the obturator foramina. In the evaluation of patients with von Recklinghausen disease, MR imaging, compared with CT, more clearly defined tumor extent within the bladder, pelvic sidewalls, and surrounding soft tissues. C1 WASHINGTON HOSP CTR,DEPT RADIOL,WASHINGTON,DC 20010. ARMED FORCES INST PATHOL,DEPT RADIOL PATHOL,WASHINGTON,DC 20306. UNIFORMED SERV UNIV HLTH SCI,DEPT RADIOL,BETHESDA,MD 20814. RP SHONNARD, KM (reprint author), WALTER REED ARMY MED CTR,DEPT RADIOL,WASHINGTON,DC 20307, USA. NR 18 TC 22 Z9 22 U1 0 U2 1 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0363-8715 J9 J COMPUT ASSIST TOMO JI J. Comput. Assist. Tomogr. PD MAY-JUN PY 1992 VL 16 IS 3 BP 433 EP 438 DI 10.1097/00004728-199205000-00017 PG 6 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA HU923 UT WOS:A1992HU92300017 PM 1592928 ER PT J AU ANDERSON, LL PHIPPS, TJ MCCOLLOUGH, ML AF ANDERSON, LL PHIPPS, TJ MCCOLLOUGH, ML TI NEUROENDOCRINE CARCINOMA OF THE SKIN (MERKEL CELL-CARCINOMA) IN A BLACK SO JOURNAL OF DERMATOLOGIC SURGERY AND ONCOLOGY LA English DT Article ID TRABECULAR CARCINOMA; ENDOCRINE TUMORS; SYNAPTOPHYSIN; NEOPLASMS; SURGERY AB Neuroendocrine carcinoma of the skin is an uncommon, small-cell neoplasm most commonly found on white, sun-exposed skin. Diagnosis by clinical and histologic means may be difficult. Immunohistochemical and ultrastructural analysis are often required. Because of the aggressive nature of neuroendocrine carcinoma of the skin, prompt diagnosis and treatment are essential. We present the rare occurrence of a neuroendocrine carcinoma of the skin on sun protected skin in a black. Clinical, histologic, immunohistochemical, and ultrastructural features are reviewed, and therapeutic options are discussed. C1 DARNELL ARMY HOSP,DEPT MED,DERMATOL SERV,FT HOOD,TX. BROOKE ARMY MED CTR,DEPT MED,FT SAM HOUSTON,TX 78234. BROOKE ARMY MED CTR,DERMATOL SERV,FT SAM HOUSTON,TX 78234. NR 40 TC 14 Z9 14 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0148-0812 J9 J DERMATOL SURG ONC PD MAY PY 1992 VL 18 IS 5 BP 375 EP 380 PG 6 WC Oncology; Dermatology; Surgery SC Oncology; Dermatology; Surgery GA HU597 UT WOS:A1992HU59700004 PM 1607460 ER PT J AU HILL, JC GRIMWOOD, RE PARSONS, DS AF HILL, JC GRIMWOOD, RE PARSONS, DS TI TREATMENT OF CHRONIC EROSIONS OF JUNCTIONAL EPIDERMOLYSIS-BULLOSA WITH HUMAN EPIDERMAL ALLOGRAFTS SO JOURNAL OF DERMATOLOGIC SURGERY AND ONCOLOGY LA English DT Article ID CULTURED EPITHELIAL AUTOGRAFTS; SUCCESSFUL ENGRAFTMENT; SKIN ULCERS; KERATINOCYTES; CELLS; GROWTH AB We have successfully treated chronic central facial erosions of a patient with junctional epidermolysis bullosa using cultured epidermal allografts. Keratinocytes isolated from a skin biopsy of the patient's biological mother were used to generate the epidermal allografts. Significant re-epithelialization occurred during the course of four grafting procedures. Cultured epidermal allografts appear to be a promising method for treatment of chronic erosions of junctional epidermolysis bullosa. C1 WILFORD HALL USAF MED CTR,DEPT DERMATOL,LACKLAND AFB,TX 78236. WILFORD HALL USAF MED CTR,DEPT OTOLARYNGOL,LACKLAND AFB,TX 78236. RP HILL, JC (reprint author), BROOKE ARMY MED CTR,DERMATOL SERV,FT SAM HOUSTON,TX 78234, USA. NR 20 TC 14 Z9 14 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0148-0812 J9 J DERMATOL SURG ONC PD MAY PY 1992 VL 18 IS 5 BP 396 EP 400 PG 5 WC Oncology; Dermatology; Surgery SC Oncology; Dermatology; Surgery GA HU597 UT WOS:A1992HU59700006 PM 1607462 ER PT J AU SUNWOO, AJ MORRIS, JW LUCEY, GK AF SUNWOO, AJ MORRIS, JW LUCEY, GK TI SOLDERABILITY OF PRE-TINNED CU SHEET SO JOURNAL OF ELECTRONIC MATERIALS LA English DT Article; Proceedings Paper CT 33RD ELECTRONIC MATERIALS CONF CY JUN, 1991 CL BOULDER, CO DE WETTING KINETICS; CU-SN INTERMETALLICS; CARBON CONTAMINATION AB The reliability and integrity of pre-tinned copper-clad printed circuit (PC) boards are serious concerns in the manufacture of electronic devices. The factors that influence the wetting during soldering of Cu are discussed. The results suggest that pre-tinning with a Pb-rich solder, such as 95Pb-5Sn, is preferred to pre-tinning with eutectic solder, since the latter can develop exposed intermetallics during aging that wet poorly. The results also confirm that the use of flux leads to carbon contamination in the solder. C1 LAWRENCE BERKELEY LAB,CTR ADV MAT,BERKELEY,CA 94720. UNIV CALIF BERKELEY,DEPT MAT SCI,BERKELEY,CA 94720. USA,HARRY DIAMOND LABS,ADELPHI,MD 20783. RP SUNWOO, AJ (reprint author), LAWRENCE LIVERMORE NATL LAB,LIVERMORE,CA 94550, USA. NR 14 TC 4 Z9 4 U1 0 U2 1 PU MINERALS METALS MATERIALS SOC PI WARRENDALE PA 420 COMMONWEALTH DR, WARRENDALE, PA 15086 SN 0361-5235 J9 J ELECTRON MATER JI J. Electron. Mater. PD MAY PY 1992 VL 21 IS 5 BP 549 EP 557 DI 10.1007/BF02655623 PG 9 WC Engineering, Electrical & Electronic; Materials Science, Multidisciplinary; Physics, Applied SC Engineering; Materials Science; Physics GA HV239 UT WOS:A1992HV23900013 ER PT J AU VIRE, DE MIKALOFF, RW AF VIRE, DE MIKALOFF, RW TI REFERENCE BLOCK FOR AUXILIARY CONES SO JOURNAL OF ENDODONTICS LA English DT Article AB A technique is described for fabricating a reference block which will allow the practitioner to select the accessory cones most correctly corresponding to the spreader used. The technique utilizes materials common to the dental office and is simple enough to allow fabrication of a new block whenever the obturation instruments or materials are changed. C1 ADV EDUC GEN DENT,FT BRAGG,NC. RP VIRE, DE (reprint author), USA DENTAC,FT BRAGG,NC 28307, USA. NR 4 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0099-2399 J9 J ENDODONT JI J. Endod. PD MAY PY 1992 VL 18 IS 5 BP 249 EP 250 DI 10.1016/S0099-2399(06)81269-0 PG 2 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA HR229 UT WOS:A1992HR22900009 PM 1402581 ER PT J AU GULLIVER, JS WILHELMS, SC AF GULLIVER, JS WILHELMS, SC TI AERATION AT OHIO RIVER BASIN NAVIGATION DAMS - DISCUSSION SO JOURNAL OF ENVIRONMENTAL ENGINEERING-ASCE LA English DT Discussion ID GAS TRANSFER C1 USA,ENGINEERS WATERWAYS EXPT STN,VICKSBURG,MS 39180. RP GULLIVER, JS (reprint author), UNIV MINNESOTA,DEPT CIVIL & MINERAL ENGN,MINNEAPOLIS,MN 55454, USA. NR 18 TC 3 Z9 3 U1 0 U2 1 PU ASCE-AMER SOC CIVIL ENGINEERS PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-9372 J9 J ENVIRON ENG-ASCE JI J. Environ. Eng.-ASCE PD MAY-JUN PY 1992 VL 118 IS 3 BP 444 EP 446 DI 10.1061/(ASCE)0733-9372(1992)118:3(444) PG 3 WC Engineering, Environmental; Engineering, Civil; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA HV096 UT WOS:A1992HV09600012 ER PT J AU GORDON, CC BUIKSTRA, JE AF GORDON, CC BUIKSTRA, JE TI LINEAR-MODELS FOR THE PREDICTION OF STATURE FROM FOOT AND BOOT DIMENSIONS SO JOURNAL OF FORENSIC SCIENCES LA English DT Article DE PHYSICAL ANTHROPOLOGY; ANTHROPOMETRY; HEIGHT ESTIMATION; FOOTPRINTS ID HEIGHT AB Estimation of stature from the dimensions of foot or shoeprints has considerable forensic value in developing descriptions of suspects from evidence at the crime scene and in corroborating height estimates from witnesses. This study extends the findings of previous researchers by exploring linear models with and without gender and race indicators, and by validating the most promising models on a large, recently collected military database. Boot size and outsole dimensions are also examined as predictors of stature. The results of this study indicate that models containing both foot length and foot breadth are significantly better than those containing only foot length. Models with race/gender indicators also perform significantly better than do models without race/gender indicators. However, the difference in performance is slight, and the availability of reliable gender and race information in most forensic situations is uncertain. Analogous results were obtained for models utilizing boot size/width and outsole length/width, and in this study these variables performed nearly as well as the foot dimensions themselves. Although the adjusted R2 values for these models clearly reflect a strong relationship between foot/boot length and stature, individual 95% prediction limits for even the best models are +/- 86 mm (3.4 in.). This suggests that models estimating stature from foot/shoe-prints may be useful in the development of subject descriptions early in a case but, because of their imprecision, may not always be helpful in excluding individual suspects from consideration. C1 USA,NATICK RES DEV & ENGN CTR,DIV BEHAV SCI,NATICK,MA 01760. UNIV CHICAGO,DEPT ANTHROPOL,CHICAGO,IL 60637. NR 11 TC 28 Z9 30 U1 0 U2 11 PU AMER SOC TESTING MATERIALS PI W CONSHOHOCKEN PA 100 BARR HARBOR DR, W CONSHOHOCKEN, PA 19428-2959 SN 0022-1198 J9 J FORENSIC SCI JI J. Forensic Sci. PD MAY PY 1992 VL 37 IS 3 BP 771 EP 782 PG 12 WC Medicine, Legal SC Legal Medicine GA JY404 UT WOS:A1992JY40400017 PM 1629672 ER PT J AU BEHNEN, AP NELSON, LK AF BEHNEN, AP NELSON, LK TI ADDITIONAL APPLICATIONS OF DIGITAL IMAGE-PROCESSING TO FORENSIC DOCUMENT EXAMINATIONS SO JOURNAL OF FORENSIC SCIENCES LA English DT Article DE QUESTIONED DOCUMENTS; DIGITAL IMAGE PROCESSING; ELECTROSTATIC DETECTION APPARATUS (ESDA); IMAGE ENHANCEMENT; PHOTOGRAPHY; SIDE-LIGHTING; QUESTIONED DOCUMENT; CARBON FILM RIBBON; EDGE FRACTURE MATCH AB Two experimental applications of digital image processing to the examination of questioned documents are evaluated. First is a comparison of digital image processing, electrostatic detection apparatus (ESDA) processing, side lighting, and photography in the decipherment of indented writing. Best results are achieved by first utilizing the ESDA, then digitally enhancing the ESDA lift using a high-pass sharpening filter. The second application is the use of image processing equipment to make fracture match comparisons to associate carbon film typewriter ribbons with questioned typescript. Split-screen images and image overlays are found to be very effective techniques for this kind of examination. Wenderoth [1] and Baier et al. [2] have reported on image processing as it relates to questioned document examination. C1 USA,CRIME LAB,CONUS,FT GILLEM,GA 30050. NR 2 TC 3 Z9 3 U1 1 U2 2 PU AMER SOC TESTING MATERIALS PI W CONSHOHOCKEN PA 100 BARR HARBOR DR, W CONSHOHOCKEN, PA 19428-2959 SN 0022-1198 J9 J FORENSIC SCI JI J. Forensic Sci. PD MAY PY 1992 VL 37 IS 3 BP 797 EP 807 PG 11 WC Medicine, Legal SC Legal Medicine GA JY404 UT WOS:A1992JY40400019 ER PT J AU FIUZAT, AA MOUGHTON, DW AF FIUZAT, AA MOUGHTON, DW TI COMPARATIVE SURVEY OF 4 UNSATURATED SOIL FLOW EQUATIONS SO JOURNAL OF HYDRAULIC ENGINEERING-ASCE LA English DT Note C1 USA,CHICAGO,IL 60606. RP FIUZAT, AA (reprint author), ENVIRONM CONSULTING ENGINEERS INC,KNOXVILLE,TN 37933, USA. NR 8 TC 0 Z9 0 U1 0 U2 0 PU ASCE-AMER SOC CIVIL ENGINEERS PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-9429 J9 J HYDRAUL ENG-ASCE JI J. Hydraul. Eng.-ASCE PD MAY PY 1992 VL 118 IS 5 BP 786 EP 791 DI 10.1061/(ASCE)0733-9429(1992)118:5(786) PG 6 WC Engineering, Civil; Engineering, Mechanical; Water Resources SC Engineering; Water Resources GA HQ625 UT WOS:A1992HQ62500008 ER PT J AU TICEHURST, J RHODES, LL KRAWCZYNSKI, K ASHER, LVS ENGLER, WF MENSING, TL CAUDILL, JD SJOGREN, MH HOKE, CH LEDUC, JW BRADLEY, DW BINN, LN AF TICEHURST, J RHODES, LL KRAWCZYNSKI, K ASHER, LVS ENGLER, WF MENSING, TL CAUDILL, JD SJOGREN, MH HOKE, CH LEDUC, JW BRADLEY, DW BINN, LN TI INFECTION OF OWL MONKEYS (AOTUS-TRIVIRGATUS) AND CYNOMOLGUS MONKEYS (MACACA-FASCICULARIS) WITH HEPATITIS-E VIRUS FROM MEXICO SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID NON-B-HEPATITIS; TRANSMITTED NON-A; IMMUNE ELECTRON-MICROSCOPY; PUTATIVE CAUSATIVE VIRUS; EPIDEMIC NON-A; TRANSMISSION; PARTICLES; MORPHOLOGY; MARMOSETS; MACAQUES AB Owl and cynomolgus monkeys were inoculated with hepatitis E virus (HEV) to compare disease models and produce antibody and virus. By immune electron microscopy (IEM), all six owl monkeys were shown to have serologic responses manifested by unusually high levels of anti-HEV at 6 months, but only three developed hepatitis. Virus-related antigen in liver (HEVAg) was detected by immunofluorescence microscopy of biopsies from two of four owl monkeys; one with HEVAg also had HEV in acute-phase bile (detected by IEM) and feces (detected by infecting another owl monkey). In contrast, cynomolgus monkeys propagated HEV to higher levels and all five had hepatitis. Moderate-to-high levels of HEVAg correlated with detectable HEV in bile for both species. Thus, the value of using HEV-infected cynomolgus was confirmed. Owl monkeys were shown to be HEV-susceptible and sources of high-level anti-HEV; Sustained anti-HEV in these monkeys may also be useful for understanding immune responses. C1 ARMED FORCES INST PATHOL,AMER REGISTRY PATHOL,DEPT CELLULAR PATHOL,WASHINGTON,DC 20306. CTR DIS CONTROL,CTR INFECT DIS,DIV VIRAL DIS,HEPATITIS BRANCH,ATLANTA,GA 30333. WALTER REED ARMY MED CTR,DIV IMMUNOL,DEPT VIRAL DIS,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DIV PATHOL,DEPT VIRAL DIS,WASHINGTON,DC 20307. USA,MED RES INST INFECT DIS,DIV DIS ASSESSMENT,FREDERICK,MD 21701. USA,MED RES INST INFECT DIS,DIV ANIM RESOURCES,FREDERICK,MD 21701. RP TICEHURST, J (reprint author), WALTER REED ARMY MED CTR,DIV COMMUNICABLE DIS,DEPT VIRAL DIS,WASHINGTON,DC 20307, USA. RI Ticehurst, John/I-7532-2012 NR 48 TC 46 Z9 48 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD MAY PY 1992 VL 165 IS 5 BP 835 EP 845 PG 11 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA HQ275 UT WOS:A1992HQ27500008 PM 1569334 ER PT J AU HERWALDT, BL KAYE, ET LEPORE, TJ BERMAN, JD BADEN, HP AF HERWALDT, BL KAYE, ET LEPORE, TJ BERMAN, JD BADEN, HP TI SODIUM STIBOGLUCONATE (PENTOSTAM) OVERDOSE DURING TREATMENT OF AMERICAN CUTANEOUS LEISHMANIASIS SO JOURNAL OF INFECTIOUS DISEASES LA English DT Note ID MUCOSAL LEISHMANIASIS; ANTIMONY; EFFICACY AB A 27-year-old woman who acquired cutaneous leishmaniasis in Central America was inadvertently treated with 10 times the intended daily dose of the pentavalent antimonial compound sodium stibogluconate (Pentostam): 8500 mg (143 mg/kg) instead of 850 mg. The patient felt "wiped out" during the 4-h infusion of the drug. After the mistake in dosing was discovered, she was vigorously hydrated and carefully monitored in an intensive care unit for > 48 h. Her vital signs were stable, and no arrhythmias were noted. Her alanine aminotransferase level rose briefly to 2.4 times the upper limit of normal, and her white blood cell count briefly fell 43% to a low of 3700/mu-l. Her skin lesions subsequently healed without further therapy. Although sodium stibogluconate has been associated with a variety of side effects, in this case, a single high dose of the drug was tolerated without serious toxicity. C1 MASSACHUSETTS GEN HOSP,DEPT DERMATOL,BOSTON,MA 02114. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NANTUCKET COTTAGE HOSP,NANTUCKET,MA. RP HERWALDT, BL (reprint author), CTR DIS CONTROL,NATL CTR INFECT DIS,DIV PARASIT DIS,MAILSTOP F-13,1600 CLIFTON RD,ATLANTA,GA 30333, USA. NR 15 TC 9 Z9 9 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD MAY PY 1992 VL 165 IS 5 BP 968 EP 971 PG 4 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA HQ275 UT WOS:A1992HQ27500034 PM 1314873 ER PT J AU MISCH, DW BURNSIDE, DF CECIL, TL AF MISCH, DW BURNSIDE, DF CECIL, TL TI A NOVEL BIOASSAY SYSTEM FOR EVALUATING THE TOXICITY OF BACILLUS-THURINGIENSIS-ISRAELENSIS AGAINST MOSQUITO LARVAE SO JOURNAL OF INVERTEBRATE PATHOLOGY LA English DT Article DE BIOASSAY; MOSQUITO LARVAE; BACILLUS-THURINGIENSIS-ISRAELENSIS (L); ACUTE TOXICITY C1 LENOIR RHYNE COLL,DEPT BIOL,HICKORY,NC 28601. USA,BIOMED RES & DEV LAB,FREDERICK,MD 21701. RP MISCH, DW (reprint author), UNIV N CAROLINA,DEPT BIOL,COKER HALL,CB 3280,CHAPEL HILL,NC 27599, USA. NR 9 TC 3 Z9 3 U1 0 U2 1 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0022-2011 J9 J INVERTEBR PATHOL JI J. Invertebr. Pathol. PD MAY PY 1992 VL 59 IS 3 BP 286 EP 289 DI 10.1016/0022-2011(92)90134-P PG 4 WC Zoology SC Zoology GA HT457 UT WOS:A1992HT45700010 PM 1607671 ER PT J AU GINGRICH, JB NISALAK, A LATENDRESSE, JR SATTABONGKOT, J HOKE, CH POMSDHIT, J CHANTALAKANA, C SATAYAPHANTA, C UECHIEWCHARNKIT, K INNIS, BL AF GINGRICH, JB NISALAK, A LATENDRESSE, JR SATTABONGKOT, J HOKE, CH POMSDHIT, J CHANTALAKANA, C SATAYAPHANTA, C UECHIEWCHARNKIT, K INNIS, BL TI JAPANESE ENCEPHALITIS-VIRUS IN BANGKOK - FACTORS INFLUENCING VECTOR INFECTIONS IN 3 SUBURBAN COMMUNITIES SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE INSECTA; CULICIDAE; JAPANESE ENCEPHALITIS VIRUS; THAILAND ID CULEX-TRITAENIORHYNCHUS; MOSQUITOS; ANTIBODIES; THAILAND AB An unexpected outbreak of Japanese encephalitis (JE) in Bangkok in 1985 led us to investigate the vector ecology of urban JE from January 1986 to June 1987 at three suburban sites that displayed a wide range of factors imputed to influence JE transmission. Culex tritaeniorhynchus Giles and Cx. gelidus Theobald, suspected vectors, comprised 71-96% of all mosquitoes collected by CO2-baited CDC traps at the three sites. Mean of mosquito abundance per two trap-nights per month ranged from 28 to 5,728 mosquitoes at the sites of lowest and highest abundance, respectively. Cx. tritaeniorhynchus yielded more JE isolates (n = 16) than Cx. gelidus (n = 7), but the minimum infection rates of the two species (number of JE isolates per 1,000 mosquitoes tested; MIR, 0.17 and 0.47, respectively) were comparable and covaried with vector abundance. Moreover, the proportion of sentinel pigs that had JE antibodies generally increased proportionately with vector abundance at the sites. Vector abundance was high in monsoon (May-October), moderate in transition (March-April and November-December), and low in dry (January-February) seasons. Mosquitoes collected in monsoon seasons yielded 96% of the JE isolates, whereas 4 and 0% of the isolates were obtained from transition and dry season collections, respectively. More pigs seroconverted in monsoon and transition seasons than in dry seasons. Indices of JE transmission activity (vector abundance, pig seroconversions, and MIRs) increased proportionately with rainfall. Despite higher indices at the site of greatest vector abundance than elsewhere, the risk of human infection appeared greatest at the site with moderate vector abundance because of its greater human population density. C1 USA,MED COMPONENT,ARMED FORCES RES INST MED SCI,BANGKOK,THAILAND. RI Latendresse, John/A-9215-2009 NR 19 TC 31 Z9 35 U1 0 U2 2 PU ENTOMOL SOC AMER PI LANHAM PA 9301 ANNAPOLIS RD, LANHAM, MD 20706 SN 0022-2585 J9 J MED ENTOMOL JI J. Med. Entomol. PD MAY PY 1992 VL 29 IS 3 BP 436 EP 444 PG 9 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA HR477 UT WOS:A1992HR47700008 PM 1320699 ER PT J AU SOLBERG, VB NEIDHARDT, K SARDELIS, MR HILDEBRANDT, C HOFFMANN, FJ BOOBAR, LR AF SOLBERG, VB NEIDHARDT, K SARDELIS, MR HILDEBRANDT, C HOFFMANN, FJ BOOBAR, LR TI QUANTITATIVE-EVALUATION OF SAMPLING METHODS FOR IXODES-DAMMINI AND AMBLYOMMA-AMERICANUM (ACARI, IXODIDAE) SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE ACARINA; IXODES-DAMMINI; AMBLYOMMA-AMERICANUM; TICK SAMPLING METHODS ID LONE-STAR TICKS; LYME-DISEASE; NEW-JERSEY; NEW-YORK; TRAPS AB Three tick-sampling methods (dry ice-baited tick traps, cloth drags, and ambulatory human host) were evaluated to determine which technique yielded the greatest capture of host-seeking stages of Ixodes dammini Spielman, Clifford, Piesman & Corwin and Amblyomma americanum (L.). The most reliable method, catching more stages and significantly more numbers of I. dammini and A. americanum, was dry ice-baited tick traps. There were no significant differences between the drag and human-host methods for any stage of ticks (I. dammini and A. americanum) collected. The numbers of ticks caught during the study were 5,052 by dry ice-baited tick traps, 199 by cloth drags, and 89 by ambulatory human host. RP SOLBERG, VB (reprint author), USA,BIOMED RES & DEV LAB,BLDG 568,FREDERICK,MD 21702, USA. NR 18 TC 26 Z9 27 U1 1 U2 15 PU ENTOMOL SOC AMER PI LANHAM PA 9301 ANNAPOLIS RD, LANHAM, MD 20706 SN 0022-2585 J9 J MED ENTOMOL JI J. Med. Entomol. PD MAY PY 1992 VL 29 IS 3 BP 451 EP 456 PG 6 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA HR477 UT WOS:A1992HR47700010 PM 1625293 ER PT J AU DURDEN, LA BEST, TL WILSON, N HILTON, CD AF DURDEN, LA BEST, TL WILSON, N HILTON, CD TI ECTOPARASITIC MITES (ACARI) OF SYMPATRIC BRAZILIAN FREE-TAILED BATS AND BIG BROWN BATS IN ALABAMA SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE ARACHNIDA; ACARI; ECTOPARASITES; BATS AB Seven species of mites were recovered from 133 Brazilian free-tailed bats, Tadarida brasiliensis, and 94 big brown bats, Eptesicus fuscus, from February through November 1990 in colonies that shared roosting space in east-central Alabama. The macronyssid Chiroptonyssus robustipes (Ewing) was the most common mite on T. brasiliensis (964 mites, 87% of bats infested) and on E. fuscus (109 mites, 29% of bats infested). However, C. robustipes normally is a specific parasite of T. brasiliensis. The macronyssids Steatonyssus ceratognathus (Ewing) and S. occidentalis (Ewing) were recovered from both species of bats in low numbers. S. ceratognathus is not a typical parasite of either species of bat, but S. occidentalis normally is specific to E. fuscus. Predictably, S. occidentalis was most frequently collected from E. fuscus (16 mites, 9% of bats infested), but two specimens were recovered from T. brasiliensis. Five specimens of the laelapid Androlaelaps casalis (Berlese) (a mite that is frequently associated with rodents) and one specimen of the myobiid mite Ewingana (Doreyana) longa (Ewing) (a specific ectoparasite of T. brasiliensis) were also recovered from T. brasiliensis. Singletons of the rosensteiniids Mydopholeus sp. and Nycteriglyphites pennsylvanicus Fain, Lukoschus & Whitaker were the only additional mites collected from E. fuscus; both of these mites have previously been collected from bats or their guano but are recorded here from Alabama for the first With respect to ectoparasite cross-infestations, E. fuscus appears to be at greater risk sharing roosts with T. brasiliensis. This is highlighted by the comparatively large numbers of C. robustipes that occurred on E. fuscus and the low numbers of S. occidentalis n T. brasiliensis. Although mites were the only arthropods recovered from bats in this study, a separate survey in 1991 revealed that the bat bug Cimex adjunctus Barber infested some other colonies of T. brasiliensis and E. fuscus in Alabama. C1 AUBURN UNIV,DEPT ZOOL & WILDLIFE SCI,AUBURN,AL 36849. AUBURN UNIV,ALABAMA AGR EXPT STN,AUBURN,AL 36849. UNIV NO IOWA,DEPT BIOL,CEDAR FALLS,IA 50614. RP DURDEN, LA (reprint author), USA,MED RES INST INFECT DIS,DEPT ARBOVIRAL ENTOMOL,DIV VIROL,FREDERICK,MD 21702, USA. NR 35 TC 11 Z9 12 U1 1 U2 6 PU ENTOMOL SOC AMER PI LANHAM PA 9301 ANNAPOLIS RD, LANHAM, MD 20706 SN 0022-2585 J9 J MED ENTOMOL JI J. Med. Entomol. PD MAY PY 1992 VL 29 IS 3 BP 507 EP 511 PG 5 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA HR477 UT WOS:A1992HR47700018 PM 1625301 ER PT J AU SCHULZE, TL TAYLOR, GC VASVARY, LM SIMMONS, W JORDAN, RA AF SCHULZE, TL TAYLOR, GC VASVARY, LM SIMMONS, W JORDAN, RA TI EFFECTIVENESS OF AN AERIAL APPLICATION OF CARBARYL IN CONTROLLING IXODES-DAMMINI (ACARI, IXODIDAE) ADULTS IN A HIGH-USE RECREATIONAL AREA IN NEW-JERSEY SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE ARACHNIDA; IXODES-DAMMINI; ACARICIDES; TICK CONTROL ID AMBLYOMMA-AMERICANUM ACARI; LYME-DISEASE; POPULATIONS AB Lyme disease risk reduction through the control of the principal tick vector, Ixodes dammini Spielman, Clifford, Piesman & Corwin, has become a major issue facing public health agencies in many endemic states. Where large tracts of land are involved, established methods of I. dammini control are impractical. An aerial application of carbaryl directed against fall populations of I. dammini adults resulted in 93.8% control after 96 h. Control persisted through the following spring. The usefulness of aerial applications may be limited to areas where logistic constraints obviate the use of conventional ground applications. C1 USA,MEDDAC,ENVIRONM HLTH SECT,PREVENT MED SERV,FT MONMOUTH,NJ 07703. RUTGERS STATE UNIV,RUTGERS COOPERAT EXTENS,NEW BRUNSWICK,NJ 08903. MONMOUTH CTY HLTH DEPT,FREEHOLD,NJ 07728. ENVIRONM CONNECT INC,FREEHOLD,NJ 07728. RP SCHULZE, TL (reprint author), NEW JERSEY STATE DEPT HLTH,DIV EPIDEMIOL & COMMUNICABLE DIS CONTROL,CN 369,TRENTON,NJ 08625, USA. NR 12 TC 26 Z9 26 U1 0 U2 4 PU ENTOMOL SOC AMER PI LANHAM PA 9301 ANNAPOLIS RD, LANHAM, MD 20706 SN 0022-2585 J9 J MED ENTOMOL JI J. Med. Entomol. PD MAY PY 1992 VL 29 IS 3 BP 544 EP 547 PG 4 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA HR477 UT WOS:A1992HR47700022 PM 1625304 ER PT J AU DURDEN, LA LINTHICUM, KJ AF DURDEN, LA LINTHICUM, KJ TI EFFICIENT LABORATORY MAINTENANCE OF BLOOD-FEEDING MESOSTIGMATID MITES (ACARI) SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Note DE ARACHNIDA; MESOSTIGMATA; LABORATORY COLONIZATION; SUCKLING MICE AB A technique is described for colonizing hematophagous mesostigmatid (= gamasid) mites under laboratory conditions. The apparatus consisted of a 473-ml (1 pint) Mason jar with sterilized surgical gauze and corrugated card placed inside on the bottom; these functioned as absorbent and mite bedding materials, respectively. A suckling mouse was placed onto the surgical gauze for 2-24 h to provide a food source for the mites. Stickem adhesive was smeared along the inside neck of the jar, which had a tight-fitting but ventilated screw-cap lid. The apparatus rested in a petri dish filled with water. This system provided excellent containment of the mites. RP DURDEN, LA (reprint author), USA,MED RES INST INFECT DIS,DEPT ARBOVIRAL ENTOMOL,DIV VIROL,FREDERICK,MD 21702, USA. NR 23 TC 2 Z9 2 U1 0 U2 0 PU ENTOMOL SOC AMER PI LANHAM PA 9301 ANNAPOLIS RD, LANHAM, MD 20706 SN 0022-2585 J9 J MED ENTOMOL JI J. Med. Entomol. PD MAY PY 1992 VL 29 IS 3 BP 564 EP 566 PG 3 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA HR477 UT WOS:A1992HR47700026 PM 1625308 ER PT J AU LIN, AJ LI, LQ ANDERSEN, SL KLAYMAN, DL AF LIN, AJ LI, LQ ANDERSEN, SL KLAYMAN, DL TI ANTIMALARIAL ACTIVITY OF NEW DIHYDROARTEMISININ DERIVATIVES .5. SUGAR ANALOGS SO JOURNAL OF MEDICINAL CHEMISTRY LA English DT Article ID ARTEMISININ; INVITRO; DRUG AB A series of dihydroartemisinin derivatives containing a sugar moiety was prepared in the search for analogues with good water solubility and high antimalarial activity. The preparation of the new compounds were achieved by treatment of dihydroartemisinin (2) with chlorotrimethylsilane in pyridine solution at -10-degrees-C to give a nearly quantitative Yield of 10-0-(trimethylsilyl)dihydroartemisinin (3), which was then condensed with 1-hydroxypolyacetylated sugars 5 to give dihydroartemisinin derivatives 7a-d. Deacetylation of intermediates 7 gave the desired sugar derivatives 8. The resulting derivatives, tested in vitro against Plasmodium falciparum, were found to be more effective against W-2 than D-6 clones and were not cross-resistant with existing antimalarials. Trimethylsilylated compound 3 is more effective than derivatives 7a-d, which possess activity comparable to or better than that of artemisinin itself. Deacetylated compounds 8a-d were substantially less active than 7 in both cell lines. In P. berghei-infected mice, 7a-c showed 5/5, 2/5, and 3/5 cures, respectively, at 320 mg/kg per day X 3, whereas 7d showed no activity at the same dosage. However, 7d did prolong the life span in 3/5 of the infected mice at 640 mg/kg per day X 3 dose level. Trimethylsilylated compound 3 was also the most effective among the compounds studied, with 5/5 cures at 80 mg/kg per day X 3. The deacetylated sugar derivatives 8a-d showed only slight in vivo antimalarial activity. RP LIN, AJ (reprint author), WALTER REED ARMY MED CTR,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307, USA. NR 24 TC 39 Z9 40 U1 0 U2 7 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0022-2623 J9 J MED CHEM JI J. Med. Chem. PD MAY 1 PY 1992 VL 35 IS 9 BP 1639 EP 1642 DI 10.1021/jm00087a021 PG 4 WC Chemistry, Medicinal SC Pharmacology & Pharmacy GA HT158 UT WOS:A1992HT15800021 PM 1578492 ER PT J AU GOYETTE, TM MCCORMICK, RI DELUCIA, FC EVERITT, HO AF GOYETTE, TM MCCORMICK, RI DELUCIA, FC EVERITT, HO TI COLLISIONS AND ROTATIONAL SPECTROSCOPY SO JOURNAL OF MOLECULAR SPECTROSCOPY LA English DT Article ID CO-HE; PRESSURE; EXCITATION C1 USA,RES OFF,RES TRIANGLE PK,NC 27709. RP GOYETTE, TM (reprint author), OHIO STATE UNIV,DEPT PHYS,COLUMBUS,OH 43210, USA. RI Everitt, Henry/L-7118-2013 OI Everitt, Henry/0000-0002-8141-3768 NR 28 TC 9 Z9 9 U1 0 U2 0 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0022-2852 J9 J MOL SPECTROSC JI J. Mol. Spectrosc. PD MAY-JUN PY 1992 VL 153 IS 1-2 BP 324 EP 339 DI 10.1016/0022-2852(92)90481-3 PG 16 WC Physics, Atomic, Molecular & Chemical; Spectroscopy SC Physics; Spectroscopy GA HT478 UT WOS:A1992HT47800030 ER PT J AU JACOB, RA PIANALTO, FS AGEE, RE AF JACOB, RA PIANALTO, FS AGEE, RE TI CELLULAR ASCORBATE DEPLETION IN HEALTHY-MEN SO JOURNAL OF NUTRITION LA English DT Article DE VITAMIN-C; ASCORBIC ACID; NUTRITIONAL STATUS ASSESSMENT; FERTILITY; HUMANS ID VITAMIN-C STATUS; BLOOD COMPONENTS; ACID; LEUKOCYTES; PLASMA AB To clarify the relationship of plasma ascorbic acid to cellular ascorbic acid levels, we determined plasma, lymphocyte, buccal cell and semen ascorbic acid in eight healthy men consuming controlled ascorbic acid intakes of 5, 10, 20, 60 or 250 mg/d over 13 wk while living in a metabolic unit. Levels of ascorbic acid in all four specimen types were significantly lower during the three lowest intakes (5, 10, or 20 mg/d) compared with the 60 or 250 mg/d intakes, but only plasma and lymphocyte ascorbic acid levels discriminated between these intakes unequivocally and with no overlap. Priority for maintenance of intracellular lymphocyte ascorbic acid was indicated by rapid repletion of lymphocytes compared with plasma and semen at 60 mg/d intake. Strong correlations of plasma with lymphocyte ascorbic acid within individuals indicated that plasma levels would reliably reflect low lymphocyte levels in nutrition monitoring surveys. Buccal cell ascorbic acid may be useful as a noninvasive screening test for ascorbic acid deficiency. Semen and sperm qualities were unchanged despite an average decline in semen ascorbic acid to 24% of baseline. Short-term ascorbic acid depletion in healthy men did not adversely affect sperm qualities related to fertility nor did moderate supplementation improve them. C1 USA,LETTERMAN ARMY MED CTR,DEPT SURG,UROL SERV,SAN FRANCISCO,CA 94129. RP JACOB, RA (reprint author), USDA ARS,WESTERN HUMAN NUTR RES CTR,SAN FRANCISCO,CA 94129, USA. NR 21 TC 46 Z9 46 U1 0 U2 0 PU AMER INST NUTRITION PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0022-3166 J9 J NUTR JI J. Nutr. PD MAY PY 1992 VL 122 IS 5 BP 1111 EP 1118 PG 8 WC Nutrition & Dietetics SC Nutrition & Dietetics GA HQ253 UT WOS:A1992HQ25300009 PM 1564563 ER PT J AU MADIGAN, WP KATZ, NNK AF MADIGAN, WP KATZ, NNK TI OCULAR TORSION-DIRECT MEASUREMENT WITH INDIRECT OPHTHALMOSCOPE AND PROTRACTOR SO JOURNAL OF PEDIATRIC OPHTHALMOLOGY & STRABISMUS LA English DT Article AB Objective measurement of the optic nerve head (ONH)-foveal angle, representing the torsional status of 40 eyes in 20 normal patients, was performed by fundus photography and compared to a method utilizing an indirect ophthalmoscope and protractor described herein. Photography established a mean ONH-foveal angle of 7.03-degrees (SD 2.94-degrees). Comparison with the indirect/protractor method revealed a mean difference of 1.10-degrees (SD 0.99) with a range of 0-degrees to 4-degrees between methods. The indirect/protractor method seems to provide a rapid, inexpensive, and accurate method of determining the degree of ocular torsion when compared to the fundus photograph method which requires greater patient cooperation and investment in time and equipment. The ONH-foveal angle varies widely among normal individuals (0-degrees to 16-degrees). Variation between left and right eyes of the same individual was not significant (1.15-degrees, SD 1.39-degrees), and if greater than 4-degrees, probably represents cyclovertical muscle dysfunction or restrictive orbitopathy. The converse, however, may not always be true as individuals with less than 4-degrees difference between eyes may have cyclovertical muscle imbalance. RP MADIGAN, WP (reprint author), WALTER REED ARMY MED CTR,OPHTHALMOL SERV,WASHINGTON,DC 20307, USA. NR 0 TC 20 Z9 21 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 SN 0191-3913 J9 J PEDIATR OPHTHALMOL JI J. Pediatr. Ophthalmol. Strabismus. PD MAY-JUN PY 1992 VL 29 IS 3 BP 171 EP 174 PG 4 WC Ophthalmology; Pediatrics SC Ophthalmology; Pediatrics GA JE702 UT WOS:A1992JE70200008 PM 1432502 ER PT J AU ADRIAN, ED IVANHOE, JR KRANTZ, WA AF ADRIAN, ED IVANHOE, JR KRANTZ, WA TI TRAJECTORY SURGICAL GUIDE STENT FOR IMPLANT PLACEMENT SO JOURNAL OF PROSTHETIC DENTISTRY LA English DT Article AB This article describes a new implant placement surgical guide that gives both implant location and trajectory to the surgeon. Radiopaque markers are placed on diagnostic dentures and a lateral cephlometric radiograph is made that shows the osseous anatomy at the symphysis and the anterior tooth location. The ideal implant location and trajectory data are transferred to a surgical stent that programs the angle and location of the fixtures at time of surgery. The stent has the additional benefit of acting as an occlusion rim, a mouth prop, and tongue retractor. Use of this stent has resulted in consistently programming the placement of implant fixtures that are prosthodontically ideal. C1 USA,DENTAC,REMOVABLE PROSTHODONT SERV,FT GORDON,GA 30905. EMORY UNIV,SCH POSTGRAD DENT,DEPT PROSTHODONT,ATLANTA,GA 30322. NR 5 TC 15 Z9 15 U1 0 U2 1 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0022-3913 J9 J PROSTHET DENT JI J. Prosthet. Dent. PD MAY PY 1992 VL 67 IS 5 BP 687 EP 691 DI 10.1016/0022-3913(92)90172-7 PG 5 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA HR466 UT WOS:A1992HR46600023 PM 1527757 ER PT J AU BASS, RA PLUMMER, KD ANDERSON, EF AF BASS, RA PLUMMER, KD ANDERSON, EF TI THE EFFECT OF A SURFACE DISINFECTANT ON A DENTAL CAST SO JOURNAL OF PROSTHETIC DENTISTRY LA English DT Article ID IMPRESSIONS; IMMERSION AB This study determined the effect of a disinfectant solution on dental casts. Stone samples were immersed in a disinfectant solution and in control solutions. The results indicate that a saturated calcium sulfate (clear slurry) solution with 0.525% sodium hypochlorite was an effective disinfectant and acted without damage to the dental cast. C1 USA,DENT ACT,DENT CORPS,ADV EDUC PROGRAM GEN DENT,FT HOOD,TX. NR 9 TC 6 Z9 6 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0022-3913 J9 J PROSTHET DENT JI J. Prosthet. Dent. PD MAY PY 1992 VL 67 IS 5 BP 723 EP 725 DI 10.1016/0022-3913(92)90179-E PG 3 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA HR466 UT WOS:A1992HR46600030 PM 1527764 ER PT J AU NETTI, CA ALBRIGHT, MD JONES, TK AF NETTI, CA ALBRIGHT, MD JONES, TK TI COMPOSITE RESIN BUTTONS USED TO DIRECT FORCES APPLIED TO TEETH BY REMOVABLE ORTHODONTIC DEVICES SO JOURNAL OF PROSTHETIC DENTISTRY LA English DT Article AB Limited orthodontic treatment prior to preparing and making prosthodontic restorations will often enhance the final outcome. A technique using grooved acid-etch composite resin buttons bonded to teeth will increase the effectiveness of removable orthondontic devices. C1 USA,DENTAC,DEPT ORTHODONT,FT RILEY,KS. USA,OIC ERLANGEN DENT CLIN,NURNBERG,GERMANY. RP NETTI, CA (reprint author), USA,AREA DENT LAB,DEPT FIXED PROSTHODONT,FT SAM HOUSTON,TX 78234, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0022-3913 J9 J PROSTHET DENT JI J. Prosthet. Dent. PD MAY PY 1992 VL 67 IS 5 BP 729 EP 731 DI 10.1016/0022-3913(92)90181-9 PG 3 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA HR466 UT WOS:A1992HR46600032 PM 1527765 ER PT J AU BLOODWORTH, KE HUNTER, JF AF BLOODWORTH, KE HUNTER, JF TI A METHOD OF FABRICATING INTERIM FIXED PARTIAL DENTURE MATRICES SO JOURNAL OF PROSTHETIC DENTISTRY LA English DT Article RP BLOODWORTH, KE (reprint author), USA,DENT CORPS,DENT ACT,FT ORP,CA 93941, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0022-3913 J9 J PROSTHET DENT JI J. Prosthet. Dent. PD MAY PY 1992 VL 67 IS 5 BP 733 EP 734 DI 10.1016/0022-3913(92)90184-C PG 2 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA HR466 UT WOS:A1992HR46600035 PM 1527768 ER PT J AU GUIDOS, BJ WEINACHT, P DOLLING, DS AF GUIDOS, BJ WEINACHT, P DOLLING, DS TI NAVIER-STOKES COMPUTATIONS FOR POINTED, SPHERICAL, AND FLAT TIPPED SHELL AT MACH-3 SO JOURNAL OF SPACECRAFT AND ROCKETS LA English DT Article ID FLOW AB A computational fluid dynamics study is described and results are shown for a tangent ogive-cylinder model with pointed, spherical, and flat nosetips at Mach number 2.95. The flow conditions simulate wind-tunnel tests conducted at the Princeton University Gas Dynamics Laboratory. The primary objective is to compare the computational and experimental results and assess the accuracy of the computational approach. Two thin-layer Navier-Stokes computational techniques are used in conjunction to compute the flowfields of interest. The first method computes the flow in the vicinity of the blunt nosetip and provides inflow conditions for the second method, which computes the flow over the remainder of the body, excluding the base region. Most of the comparisons of the nosetip flow structure, surface pressure distribution, and turbulent boundary-layer velocity profiles are within the measurement accuracy. C1 UNIV TEXAS,DEPT AEROSP ENGN & ENGN MECH,AUSTIN,TX 78758. RP GUIDOS, BJ (reprint author), USA,BALLIST RES LABS,COMPUTAT AERODYNAM BRANCH,ABERDEEN PROVING GROUND,MD 21005, USA. NR 20 TC 3 Z9 3 U1 0 U2 0 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091 SN 0022-4650 J9 J SPACECRAFT ROCKETS JI J. Spacecr. Rockets PD MAY-JUN PY 1992 VL 29 IS 3 BP 305 EP 311 DI 10.2514/3.26352 PG 7 WC Engineering, Aerospace SC Engineering GA HZ095 UT WOS:A1992HZ09500002 ER PT J AU DANBERG, JE NIETUBICZ, CJ AF DANBERG, JE NIETUBICZ, CJ TI PREDICTED FLIGHT PERFORMANCE OF BASE-BLEED PROJECTILES SO JOURNAL OF SPACECRAFT AND ROCKETS LA English DT Article AB Current Army programs are applying a base-bleed concept to achieve increased range for projectiles. Base bleed is a technique in which low-speed mass is injected into the base region to reduce base drag and extend range. The U.S. Army Ballistic Research Laboratory is developing an engineering computational model capable of predicting the flight performance. The model analyzes three problem elements: a solid propellant gas generator, the effect of injection on the aerodynamic drag, and trajectory computations. Because each element is time dependent, all three must be solved simultaneously. The analysis is based on experimental and numerical data generated for the M864 base-bleed projectile. Navier-Stokes computations for the near wake region have been performed on the Army's Cray X-MP/48 supercomputer. The results were used to correlate base pressure change with injection rate, gas temperature, and Mach number. These results provide critical data for the analysis. The mass generation analysis is combined with the effect of mass injection on base pressure to obtain the projectile base drag at each step of a two-dimensional, point-mass trajectory computation. Computed results are in reasonable agreement with the flight data. Ranges are predicted within 4.2%. RP DANBERG, JE (reprint author), USA,BALLIST RES LABS,ABERDEEN PROVING GROUND,MD 21005, USA. NR 17 TC 4 Z9 5 U1 1 U2 1 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091 SN 0022-4650 J9 J SPACECRAFT ROCKETS JI J. Spacecr. Rockets PD MAY-JUN PY 1992 VL 29 IS 3 BP 366 EP 372 DI 10.2514/3.26360 PG 7 WC Engineering, Aerospace SC Engineering GA HZ095 UT WOS:A1992HZ09500010 ER PT J AU CHASTEN, CP LU, LW DRISCOLL, GC AF CHASTEN, CP LU, LW DRISCOLL, GC TI PRYING AND SHEAR IN END-PLATE CONNECTION DESIGN SO JOURNAL OF STRUCTURAL ENGINEERING-ASCE LA English DT Article ID BEHAVIOR AB Seven large, extended end-plate connections with eight tension bolts were fabricated and tested to failure at the Fritz Engineering Laboratory. Lehigh University. At least one connection failed by bolt fracture, weld fracture, or plate shear fracture. Experimental results led to concerns for bolt prying forces and end-plate shear forces. Finite element analysis models, using shell elements for the end plate and beam flanges and plane-stress elements for the beam web, were developed for the connections. Elastic and inelastic finite element solutions were obtained by using the ADINA program to provide predictions of the magnitude of shear force in the plate projection and the increases in bolt force due to prying action. The analytically predicted bolt forces were compared with the experimentally measured forces and reasonable agreement was found. Simple design rules, which complement the current design procedures for unstiffened end-plate connections, are presented. C1 LEHIGH UNIV,CTR ADV TECH LARGE STRUCT SYST,BETHLEHEM,PA 18015. RP CHASTEN, CP (reprint author), USA,CORPS ENGINEERS,WATERWAYS EXPT STN,VICKSBURG,MS 39180, USA. NR 19 TC 14 Z9 19 U1 0 U2 0 PU ASCE-AMER SOC CIVIL ENGINEERS PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-9445 J9 J STRUCT ENG-ASCE JI J. Struct. Eng.-ASCE PD MAY PY 1992 VL 118 IS 5 BP 1295 EP 1311 DI 10.1061/(ASCE)0733-9445(1992)118:5(1295) PG 17 WC Construction & Building Technology; Engineering, Civil SC Construction & Building Technology; Engineering GA HQ237 UT WOS:A1992HQ23700009 ER PT J AU DOWLING, JP AF DOWLING, JP TI SONIC BAND-STRUCTURE IN FLUIDS WITH PERIODIC DENSITY VARIATIONS SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Article ID SPONTANEOUS EMISSION AB In direct analogy to the electronic band structure found in semiconductors and the photonic bands for light in a medium with a periodic dielectric constant, a periodic density variation in a fluid can give rise to sonic frequency passbands and band gaps. Hence, a fluid medium can be constructed that prohibits sound propagation at certain frequencies while allowing practically free propagation at others. The effect of a sonic band medium on a monopole acoustic source is discussed in a simple one-dimensional model. In particular, the complete quenching of radiated power is seen for a harmonic radiator at a frequency that corresponds to a band gap-in analogy with a similar effect that is predicted for the atomic emission of electromagnetic waves in a photonic band structure. The ability to construct a medium that selectively prohibits sound propagation and emission in a certain range of frequencies, while allowing transmission and enhanced radiation rates at others, could have interesting practical applications. RP DOWLING, JP (reprint author), USA,MISSILE COMMAND,CTR RES DEV & ENGN,AMSMI,RD,WS,ST,REDSTONE ARSENAL,AL 35898, USA. RI DOWLING, JONATHAN/L-2749-2013 NR 13 TC 53 Z9 53 U1 1 U2 6 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0001-4966 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD MAY PY 1992 VL 91 IS 5 BP 2539 EP 2543 DI 10.1121/1.402990 PG 5 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA HT688 UT WOS:A1992HT68800006 ER PT J AU VENKATESAN, V DAS, K FOUNTAIN, GG RUDDER, RA POSTHILL, JB MARKUNAS, RJ AF VENKATESAN, V DAS, K FOUNTAIN, GG RUDDER, RA POSTHILL, JB MARKUNAS, RJ TI EFFECT OF THIN INTERFACIAL SIO2-FILMS ON METAL CONTACTS TO B-DOPED DIAMOND FILMS SO JOURNAL OF THE ELECTROCHEMICAL SOCIETY LA English DT Article ID CHEMICAL-VAPOR-DEPOSITION; PLASMA; ELECTRONICS AB The effect of thin interfacial films Of SiO2 (approximately 20 angstrom) on the electrical characteristics of metal contacts fabricated on Polycrystalline and homoepitaxial diamond films has been studied. The diamond films were grown using plasma-enhanced chemical vapor deposition techniques. In order to minimize the effect of defects and/or hydrogen on the metal contact characteristics, these films were annealed at 950-degrees-C for 30 min. Metal-semiconductor contacts were formed by electron-beam evaporation of Al on both as-received and annealed polycrystalline films, whereas, Au metallization was used for the homoepitaxial film. Active diode areas were defined by a standard photolithographic process. It has been demonstrated in this investigation that, in certain cases, the introduction of a thin SiO2 film at the interface between the metal and the diamond semiconductor film allows the fabrication of a rectifying contact that is not obtainable without the interfacial film. C1 RES TRIANGLE INST,RES TRIANGLE PK,NC 27709. RP VENKATESAN, V (reprint author), USA,CTR ELECTR MAT,KOBE STEEL RES LABS,RES TRIANGLE PK,NC 27709, USA. NR 27 TC 9 Z9 9 U1 0 U2 1 PU ELECTROCHEMICAL SOC INC PI PENNINGTON PA 10 SOUTH MAIN STREET, PENNINGTON, NJ 08534 SN 0013-4651 J9 J ELECTROCHEM SOC JI J. Electrochem. Soc. PD MAY PY 1992 VL 139 IS 5 BP 1445 EP 1449 DI 10.1149/1.2069428 PG 5 WC Electrochemistry; Materials Science, Coatings & Films SC Electrochemistry; Materials Science GA HU228 UT WOS:A1992HU22800046 ER PT J AU GALBICKA, G AF GALBICKA, G TI THE DYNAMICS OF BEHAVIOR SO JOURNAL OF THE EXPERIMENTAL ANALYSIS OF BEHAVIOR LA English DT Editorial Material ID REINFORCEMENT; CONTINGENCY RP GALBICKA, G (reprint author), WALTER REED ARMY MED CTR,WASHINGTON,DC 20307, USA. NR 27 TC 7 Z9 7 U1 1 U2 1 PU SOC EXP ANALYSIS BEHAVIOR INC PI BLOOMINGTON PA INDIANA UNIV DEPT PSYCHOLOGY, BLOOMINGTON, IN 47405 SN 0022-5002 J9 J EXP ANAL BEHAV JI J. Exp. Anal. Behav. PD MAY PY 1992 VL 57 IS 3 BP 243 EP 248 DI 10.1901/jeab.1992.57-243 PG 6 WC Psychology, Biological; Behavioral Sciences; Psychology, Experimental SC Psychology; Behavioral Sciences GA HU533 UT WOS:A1992HU53300001 PM 16812654 ER PT J AU LIPP, LJ AF LIPP, LJ TI METHODOLOGY OF DEVELOPING A COMBINED ENVIRONMENTAL-STRESS SCHEDULE FOR RELIABILITY GROWTH TESTING .1. DETERMINING THE ENVIRONMENTAL STRESSES FROM AN OPERATIONAL MODE SUMMARY MISSION PROFILE (OMS/MP) SO JOURNAL OF THE IES LA English DT Article DE TEST TAILORING; RELIABILITY GROWTH; MISSION PROFILES AB This article, the first of a three-part series, describes how to develop an environmental test schedule for military, ground-mobile equipment installed on a tracked vehicle based on the user's mission profile. The test schedules combine both operational and storage environmental stresses. Part I describes the equipment to be tested, provides a general overview of its mission profiles, and identifies appropriate climatic conditions. Part II discusses the complexities of the tracked-vehicle vibration environment, including research conducted in the Arizona desert and the Alaskan arctic. Part III compares test profiles based on excluding benign environmental phases with profiles that include benign stress conditions. RP LIPP, LJ (reprint author), USA,ARMAMENT MUNIT & CHEM COMMAND,ABERDEEN PROVING GROUND,MD 21010, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU INST ENVIRONMENTAL SCI PI MT PROSPECT PA 940 E NORTHWEST HIGHWAY, MT PROSPECT, IL 60056 SN 1052-2883 J9 J IES JI J. IES PD MAY-JUN PY 1992 VL 35 IS 3 BP 45 EP 49 PG 5 WC Engineering, Environmental; Environmental Sciences; Instruments & Instrumentation SC Engineering; Environmental Sciences & Ecology; Instruments & Instrumentation GA JA790 UT WOS:A1992JA79000005 ER PT J AU CHYLEK, P NGO, D PINNICK, RG AF CHYLEK, P NGO, D PINNICK, RG TI RESONANCE STRUCTURE OF COMPOSITE AND SLIGHTLY ABSORBING SPHERES SO JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION LA English DT Article ID STIMULATED RAMAN-SCATTERING; PARTIAL-WAVE RESONANCES; 2 DIELECTRIC SPHERES; MIE SCATTERING; ELECTROMAGNETIC SCATTERING; INHOMOGENEOUS-MEDIUM; OPTICAL RESONANCES; LIQUID DROPLETS; FIELD; MICRODROPLETS AB Using optical levitation of individual 3-10-mu-m droplets, we investigate the resonance structure of the light intensity scattered at an angle of approximately 90-degrees by a dielectric droplet, a slightly absorbing droplet, and composite inhomogeneous droplets. We find in all the cases that the resonance structures of dielectric, weakly absorbing, and composite inhomogeneous spheres are almost identical for the imaginary part of the refractive index (or of an effective refractive index for the case of a composite sphere) smaller than 10(-5). Thus a small amount of highly absorbing material dispersed in a dielectric sphere does not destroy its resonance characteristics. C1 SUNY ALBANY,DEPT ATMOSPHER SCI,ALBANY,NY 12222. NEW MEXICO STATE UNIV,DEPT PHYS,LAS CRUCES,NM 88003. SUNY ALBANY,ATMOSPHER SCI RES CTR,ALBANY,NY 12222. ATMOSPHER SCI LAB,WHITE SANDS MISSILE RANGE,NM 88002. RP CHYLEK, P (reprint author), DALHOUSIE UNIV,DEPT PHYS & OCEANOG,ATMOSPHER SCI PROGRAM,HALIFAX B3H 3J5,NS,CANADA. NR 32 TC 22 Z9 22 U1 0 U2 0 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0740-3232 J9 J OPT SOC AM A JI J. Opt. Soc. Am. A-Opt. Image Sci. Vis. PD MAY PY 1992 VL 9 IS 5 BP 775 EP 780 DI 10.1364/JOSAA.9.000775 PG 6 WC Optics SC Optics GA HQ478 UT WOS:A1992HQ47800015 ER PT J AU DURKOT, MJ FRANCESCONI, R HUBBARD, R AF DURKOT, MJ FRANCESCONI, R HUBBARD, R TI THE RELATIONSHIP OF PLASMA-CATECHOLAMINES TO PERIPHERAL-BLOOD FLOW AND THERMOREGULATION DURING EXERCISE IN THE HEAT SO JOURNAL OF THERMAL BIOLOGY LA English DT Article DE BLOOD FLOW; THERMOREGULATION; EXERCISE; CATECHOLAMINES; EXHAUSTION ID RAT; HYPERTHERMIA; CIRCULATION; RESPONSES AB 1. Male rats (350 g) were exercised to exhaustion in a climatic chamber (30-degrees-C) on a motor-driven treadmill (11 m/min, 6-degrees incline) to determine the role of adrenergic hormonal activity in the control of blood flow during exercise in the heat. 2. During exercise, significant (P < 0.05) increases occurred in both central and peripheral temperature and blood pressure, metabolic rate and plasma corticosterone. Epinephrine and norepinephrine were only moderately increased. However, at exhaustion both peripheral temperature and blood pressure decreased while the plasma catecholamines levels were significantly (P < 0.05) elevated. 3. We concluded that as the rat approaches hyperthermic exhaustion, a catecholamine-induced vasoconstriction of the tail contributed to sustaining central blood pressure and cardiac output at the expense of peripheral temperature regulation. RP DURKOT, MJ (reprint author), USA,ENVIRONM MED RES INST,SGRD,UE,EPC,NATICK,MA 01760, USA. NR 31 TC 2 Z9 2 U1 0 U2 3 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0306-4565 J9 J THERM BIOL JI J. Therm. Biol. PD MAY PY 1992 VL 17 IS 3 BP 155 EP 159 DI 10.1016/0306-4565(92)90027-D PG 5 WC Biology; Zoology SC Life Sciences & Biomedicine - Other Topics; Zoology GA JD690 UT WOS:A1992JD69000005 ER PT J AU ROLLINGS, RS PITTMAN, DW AF ROLLINGS, RS PITTMAN, DW TI FIELD INSTRUMENTATION AND PERFORMANCE MONITORING OF RIGID PAVEMENTS SO JOURNAL OF TRANSPORTATION ENGINEERING-ASCE LA English DT Article AB This paper reviews some of the past instrumentation and performance measuring used by the U.S. Army Corps of Engineers to develop its rigid-pavement design procedures, and it will consider two areas where future studies could improve our understanding of rigid pavement performance. Results of instrumental model tests and full-scale traffic tests gave confidence in the Westergaard edge-loaded analytical model to calculate design stresses. This model has been the backbone of the design concept for more than 40 years, and it continues to serve the Corps well. Also, performance measurements of joints developed the concept of joint load transfer that allowed more economical design of pavements and that also defined standards of joint design. There are still challenges facing the Corps, where instrumentation and performance measurements in the field can help develop better design standards. The actual effects of temperature and moisture gradients on rigid-pavement performance and bonding in rigid-pavement overlays remain poor and could be improved by field measurements. RP ROLLINGS, RS (reprint author), USA,DIV PAVEMENT SYST,VICKSBURG,MS 39180, USA. NR 0 TC 5 Z9 5 U1 0 U2 0 PU ASCE-AMER SOC CIVIL ENGINEERS PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-947X J9 J TRANSP ENG-ASCE JI J. Transp. Eng.-ASCE PD MAY-JUN PY 1992 VL 118 IS 3 BP 361 EP 370 DI 10.1061/(ASCE)0733-947X(1992)118:3(361) PG 10 WC Engineering, Civil; Transportation Science & Technology SC Engineering; Transportation GA HQ629 UT WOS:A1992HQ62900002 ER PT J AU OFFNER, PJ RIVARA, FP MAIER, RV AF OFFNER, PJ RIVARA, FP MAIER, RV TI THE IMPACT OF MOTORCYCLE HELMET USE SO JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE LA English DT Article; Proceedings Paper CT 51ST ANNUAL SESSION OF THE AMERICAN ASSOC FOR THE SURGERY OF TRAUMA CY SEP 11-14, 1991 CL PHILADELPHIA, PA SP AMER ASSOC SURG TRAUMA ID INJURY SEVERITY SCORE; TRAUMA; COST; CHARGES; LAWS AB Mandatory motorcycle helmet-use legislation is supported by the high morbidity of motorcycle trauma and its cost to society. Opponents argue, however, that the majority of motorcycle trauma morbidity and costs are the result of injuries to body regions other than the head. Previous data do not address this argument because they fail to control for differences in non-head injury severity (i.e., kinetic impact) between helmeted and unhelmeted patients. This study investigates the impact of helmet use on the morbidity and cost of motorcycle trauma, after controlling for non-head injuries. A retrospective review of all patients admitted to Harborview Medical Center with motorcycle trauma from 1/1/85 to 1/1/90 was performed. Non-head injury severity was determined by calculating an ISS that did not include head injury. This non-head ISS was used to control for injury severity below the neck. Four hundred twenty-five patients were identified. Stratified analysis showed that helmet use decreased the need for and duration of mechanical ventilation, the length of ICU stay, the need for rehabilitation, and prevented head injury. Costs of acute care were significantly less in helmeted patients. Regression analysis, controlling for age, gender, and blood alcohol level (as well as non-head injury severity), confirmed that acute costs were 40% less with helmet use. C1 UNIV WASHINGTON,SCH PUBL HLTH & COMMUNITY MED,DEPT EPIDEMIOL,SEATTLE,WA 98195. UNIV WASHINGTON,SCH MED,DEPT PEDIAT,SEATTLE,WA 98195. UNIV WASHINGTON,SCH MED,DEPT SURG,SEATTLE,WA 98195. RP OFFNER, PJ (reprint author), BROOKE ARMY MED CTR,DEPT SURG,CRIT CARE SERV,FT SAM HOUSTON,TX 78234, USA. NR 27 TC 39 Z9 39 U1 1 U2 4 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 1079-6061 J9 J TRAUMA JI J. Trauma-Injury Infect. Crit. Care PD MAY PY 1992 VL 32 IS 5 BP 636 EP 642 DI 10.1097/00005373-199205000-00016 PG 7 WC Critical Care Medicine; Surgery SC General & Internal Medicine; Surgery GA HW811 UT WOS:A1992HW81100016 PM 1588653 ER PT J AU COSTABILE, RA SKOOG, S RADOWICH, M AF COSTABILE, RA SKOOG, S RADOWICH, M TI TESTICULAR VOLUME ASSESSMENT IN THE ADOLESCENT WITH A VARICOCELE SO JOURNAL OF UROLOGY LA English DT Article DE ADOLESCENCE; TESTIS; VARICOCELE; ULTRASONIC DIAGNOSIS ID BLOOD-FLOW; REPAIR; TEMPERATURE; REVERSAL; TESTIS AB Testicular growth arrest is the main criterion for performing varicocele ligation in the adolescent population. Previous assessments concerning significant size discrepancy range from 0.5 to 5 cm.3, a 10-fold difference. We prospectively assessed testicular size in 22 male adolescents (ages 9 to 19 years) with varicoceles, and compared testicular volume as measured by ultrasound and Prader orchidometer in 19 of these patients. The accuracy of ultrasound for this purpose was evaluated by blinded ultrasonic measurements of models of known volume and a standard deviation of +/- 1.6 cm.3 was found. Using a size discrepancy of greater than 2 cm.3 as the criterion for growth arrest, 4 of 17 patients (24%) with growth arrest would have been missed with the Prader orchidometer alone. Testicular volumetric assessment by ultrasound accurately measured volumetric differences of greater than 2 cm.3 and can be used to determine growth arrest in the male adolescent with a varicocele. C1 WALTER REED ARMY MED CTR,DEPT UROL,WASHINGTON,DC 20307. NR 23 TC 63 Z9 68 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-5347 J9 J UROLOGY JI J. Urol. PD MAY PY 1992 VL 147 IS 5 BP 1348 EP 1350 PG 3 WC Urology & Nephrology SC Urology & Nephrology GA HR463 UT WOS:A1992HR46300052 PM 1569681 ER PT J AU MEYYAPPAN, M MCLANE, GF LEE, HS ECKART, D NAMAROFF, M SASSERATH, J AF MEYYAPPAN, M MCLANE, GF LEE, HS ECKART, D NAMAROFF, M SASSERATH, J TI MAGNETRON REACTIVE ION ETCHING OF GAAS IN SICL4 SO JOURNAL OF VACUUM SCIENCE & TECHNOLOGY B LA English DT Note ID DAMAGE; SURFACE AB Magnetron reactive ion etching of GaAs was investigated for the first time in a SiCl4 plasma as a function of process parameters such as pressure and power density. The etch rate of GaAs is found to be much faster than the figures reported for conventional (unmagnetized) reactive ion etching. Vertical sidewalls and smooth surface morphology were obtained under the reported experimental conditions. Schottky diodes were fabricated on etched samples to assess the extent of residual damage. The ideality factor and barrier height of the etched samples were found to be close to those of an unetched control sample. The results indicate that SiCl4 magnetron etching has promise for use in GaAs device fabrication. C1 USA,ELECTR TECHNOL & DEVICES LAB,FT MONMOUTH,NJ 07703. MAT RES CORP,ORANGEBURG,NY 10962. RP MEYYAPPAN, M (reprint author), SCI RES ASSOCIATES INC,GLASTONBURY,CT 06033, USA. NR 16 TC 8 Z9 8 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 1071-1023 J9 J VAC SCI TECHNOL B JI J. Vac. Sci. Technol. B PD MAY-JUN PY 1992 VL 10 IS 3 BP 1215 EP 1217 DI 10.1116/1.585890 PG 3 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Physics, Applied SC Engineering; Science & Technology - Other Topics; Physics GA HZ485 UT WOS:A1992HZ48500026 ER PT J AU FELDMAN, AD AF FELDMAN, AD TI SYSTEMS-ANALYSIS APPLICATIONS AT THE HYDROLOGIC ENGINEERING CENTER SO JOURNAL OF WATER RESOURCES PLANNING AND MANAGEMENT-ASCE LA English DT Article AB In the broadest sense of systems analysis, the Hydrologic Engineering Center (HEC) has been actively applying systems analysis techniques since its inception in 1964. HEC's basic systems analysis method has been the simulation of watershed and river basin processes. Several other systems analysis activities are an outgrowth of that basic simulation capability: automated parameter estimation algorithms, synthetic streamflow generation, network analysis, branch-and-bound search techniques, numerical methods, risk and uncertainty analysis, and expert systems. Systems analysis at the HEC has been an approach to problem solving as much as the actual technical methods. This philosophy of problem solving can be likened to a local hardware store's approach to do-it-yourself home repair. The hardware store personnel make a genuine effort to understand the homeowner's problem; then, they offer tools, supplies, and advice to solve the problem. Examples of these systems analysis techniques and their application to hydrologic engineering problem solving are presented in this paper. RP FELDMAN, AD (reprint author), USA,CORPS ENGINEERS,CTR HYDROL ENGN,DIV RES,DAVIS,CA 95616, USA. NR 20 TC 3 Z9 3 U1 1 U2 2 PU ASCE-AMER SOC CIVIL ENGINEERS PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-9496 J9 J WATER RES PL-ASCE JI J. Water Resour. Plan. Manage.-ASCE PD MAY-JUN PY 1992 VL 118 IS 3 BP 249 EP 261 DI 10.1061/(ASCE)0733-9496(1992)118:3(249) PG 13 WC Engineering, Civil; Water Resources SC Engineering; Water Resources GA HQ223 UT WOS:A1992HQ22300005 ER PT J AU CLEMENT, J LEDUC, J TOMIYAMA, T LEE, HW AF CLEMENT, J LEDUC, J TOMIYAMA, T LEE, HW TI SCREENING OF EUROPEAN HANTAVIRUS NEPHROPATHY (HVN) WITH HIGH-DENSITY PARTICLE AGGLUTINATION (HDPA) SO KIDNEY INTERNATIONAL LA English DT Meeting Abstract C1 MILITARY HOSP,BRUSSELS,BELGIUM. USA,MED RES INST INFECT DIS,FREDERICK,MD 21701. UNIV TOKYO,BRANCH HOSP,TOKYO 113,JAPAN. INST VIRAL DIS,SEOUL,SOUTH KOREA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU BLACKWELL SCIENCE INC PI MALDEN PA 350 MAIN ST, MALDEN, MA 02148 SN 0085-2538 J9 KIDNEY INT JI Kidney Int. PD MAY PY 1992 VL 41 IS 5 BP 1431 EP 1432 PG 2 WC Urology & Nephrology SC Urology & Nephrology GA HQ647 UT WOS:A1992HQ64700044 ER PT J AU COOK, JE WENGER, CB KOLKA, MA AF COOK, JE WENGER, CB KOLKA, MA TI CHRONIC PYRIDOSTIGMINE BROMIDE ADMINISTRATION - SIDE-EFFECTS AMONG SOLDIERS WORKING IN A DESERT ENVIRONMENT SO MILITARY MEDICINE LA English DT Article AB The side effects of chronic pyridostigmine bromide administration were studied in seven male soldiers performing moderate-intensity exercise in a desert environment. A 2-week, double-blind, placebo-controlled crossover design was employed in which pyridostigmine was administered for 7 consecutive days (30 mg orally, t.i.d.). Four hours each day were spent in the heat (42-degrees-C, 20% relative humidity); 2 hours rest followed by 2 hours moderate exercise (40% maximal aerobic power). Each day, subjects completed four symptom questionnaires and received three focused physical examinations. Symptoms reported did not differ between treatment groups except for fewer headaches during pyridostigmine treatment. Soldiers were unable to distinguish the effects of pyridostigmine from placebo. Pyridostigmine was associated with lower resting diastolic blood pressure (approximately 4 mmHg, p < 0.05), smaller pupil diameter (approximately 0.5 mm, p < 0.01), decreased handgrip strength (approximately 3%, p < 0.05), and higher final rectal temperature (approximately 0.1-degrees-C, p < 0. 01). Effects of this magnitude are not likely to appreciably limit performance. We conclude that chronic pyridostigmine administration does not negatively impact on soldiers' ability to perform physical work over repeated days in a desert environment. RP COOK, JE (reprint author), USA,ENVIRONM MED RES INST,DIV THERMAL PHYSIOL & MED,NATICK,MA 01760, USA. NR 0 TC 46 Z9 46 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAY PY 1992 VL 157 IS 5 BP 250 EP 254 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA HT318 UT WOS:A1992HT31800014 PM 1630657 ER PT J AU DARRIGRAND, A REYNOLDS, K JACKSON, R HAMLET, M ROBERTS, D AF DARRIGRAND, A REYNOLDS, K JACKSON, R HAMLET, M ROBERTS, D TI EFFICACY OF ANTIPERSPIRANTS ON FEET SO MILITARY MEDICINE LA English DT Article AB Nineteen male soldiers participated in a study of the effectiveness of two antiperspirants (aluminum chlorohydrate and aluminum zirconium tetrachlorohydrex glycine) in reducing foot-sweat accumulation and injuries. Each subject was tested before and after antiperspirant application, with a 1-hour treadmill march at 5.6 km/hour in a warm environment. Both antiperspirants decreased (p < 0.05) foot-sweat accumulation over 50%. There was also a tendency, although not statistically significant, for subjects to incur fewer blisters with antiperspirant use. However, the antiperspirants also increased (p < 0.05) the incidence of irritant dermatitis. Nevertheless, these data suggest that the application of antiperspirants to the feet has merit in reducing serious foot injuries (blisters, trench foot) exacerbated by wet feet. RP DARRIGRAND, A (reprint author), USA,ENVIRONM MED RES INST,DIV RES PROG & OPS,NATICK,MA 01760, USA. NR 0 TC 12 Z9 12 U1 0 U2 2 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAY PY 1992 VL 157 IS 5 BP 256 EP 259 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA HT318 UT WOS:A1992HT31800016 PM 1630659 ER PT J AU GUNDERSON, CH LEHMANN, CR SIDELL, FR JABBARI, B AF GUNDERSON, CH LEHMANN, CR SIDELL, FR JABBARI, B TI NERVE AGENTS - A REVIEW SO NEUROLOGY LA English DT Review ID BIOLOGICAL WARFARE; CHEMICAL WEAPONS; MEDICAL DEFENSE; ATROPINE; SARIN C1 WALTER REED ARMY MED CTR,NEUROL SERV,WASHINGTON,DC 20307. USA,MED MAT DEV ACT,FREDERICK,MD 21701. USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010. RP GUNDERSON, CH (reprint author), UNIFORMED SERV UNIV HLTH SCI,DEPT NEUROL,4301 JONES BRIDGE RD,BETHESDA,MD 20814, USA. NR 25 TC 86 Z9 88 U1 0 U2 9 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0028-3878 J9 NEUROLOGY JI Neurology PD MAY PY 1992 VL 42 IS 5 BP 946 EP 950 PG 5 WC Clinical Neurology SC Neurosciences & Neurology GA HT665 UT WOS:A1992HT66500002 PM 1315942 ER PT J AU DIAZ, JM URBAN, ES SCHIFFMAN, JS PETERSON, AC AF DIAZ, JM URBAN, ES SCHIFFMAN, JS PETERSON, AC TI POSTIRRADIATION NEUROMYOTONIA AFFECTING TRIGEMINAL NERVE DISTRIBUTION - AN UNUSUAL PRESENTATION SO NEUROLOGY LA English DT Note ID OCULAR NEUROMYOTONIA; RADIATION-THERAPY; PLEXOPATHY; MOTOR AB We describe two patients who developed neuromyotonia of the floor of the mouth after irradiation of a motor branch (V3) of the trigeminal nerve. The neuromyotonia manifested as sustained muscle contraction due to peripheral nerve dysfunction. The neuromyotonia in both patients was controlled with carbamazepine. Radiation-exposed nerves can become symptomatic months or years after completion of radiation therapy. C1 WALTER REED ARMY MED CTR,NEUROL SERV,WASHINGTON,DC 20307. LETTERMAN ARMY MED CTR,OPHTHALMOL SERV,PRESIDIO OF SAN FRANCISCO,CA. IOWA CLIN,CEDAR RAPIDS,IA. RP DIAZ, JM (reprint author), WILLIAM BEAUMONT ARMY MED CTR,DEPT MED,NEUROL SERV,FT BLISS,TX 79920, USA. NR 9 TC 24 Z9 24 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0028-3878 J9 NEUROLOGY JI Neurology PD MAY PY 1992 VL 42 IS 5 BP 1102 EP 1104 PG 3 WC Clinical Neurology SC Neurosciences & Neurology GA HT665 UT WOS:A1992HT66500032 PM 1579234 ER PT J AU WALTON, TL AF WALTON, TL TI WAVE REFLECTION FROM NATURAL BEACHES SO OCEAN ENGINEERING LA English DT Article ID SURFACE GRAVITY-WAVES AB The reflection of wave energy from natural beaches is a quantity that is rarely measured. This paper addresses the question as to whether the reflected wave energy from a beach is an important component of energy flux from an engineering point of view. Wave run-up and wave set-up are important nearshore processes in which wave reflection appears to play a major role and, consequently, the prediction of reflected wave energy from the offshore forcing irregular wave train energy at natural beaches is a first step in a better understanding of these processes. The present paper reports on wave reflection measurements at two natural beaches with different characteristics. The issue of wave reflection is addressed via separation of input and output signals using coincident pressure and velocity measurements. In the present limited analysis, reflected wave energy was not found to be significant. RP WALTON, TL (reprint author), USA,CORPS ENGINEERS,COASTAL ENGN RES CTR,USAE,WATERWAYS EXPT STN,VICKSBURG,MS 39180, USA. NR 20 TC 8 Z9 8 U1 1 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0029-8018 J9 OCEAN ENG JI Ocean Eng. PD MAY PY 1992 VL 19 IS 3 BP 239 EP 258 DI 10.1016/0029-8018(92)90027-2 PG 20 WC Engineering, Marine; Engineering, Civil; Engineering, Ocean; Oceanography SC Engineering; Oceanography GA JA915 UT WOS:A1992JA91500002 ER PT J AU HOWARD, OMZ DEAN, M YOUNG, H RAMSBURG, M TURPIN, JA MICHIEL, DF KELVIN, DJ LEE, L FARRAR, WL AF HOWARD, OMZ DEAN, M YOUNG, H RAMSBURG, M TURPIN, JA MICHIEL, DF KELVIN, DJ LEE, L FARRAR, WL TI CHARACTERIZATION OF A CLASS-3 TYROSINE KINASE SO ONCOGENE LA English DT Article ID COLONY-STIMULATING FACTOR; SIGNAL TRANSDUCTION; CATALYTIC DOMAINS; CELL-LINES; EXPRESSION; GENE; IDENTIFICATION; ACTIVATION; SEQUENCE; P56LCK AB In an effort to identify unique tyrosine kinases found in human leukemia cell lines, we utilized polymerase chain reaction (PCR) technology and degenerate oligonucleotide primers to produce a cDNA library of kinase catalytic domains found in the human monocytic cell line AML-193. This search yielded a member of the class 3 tyrosine kinases closely related to the murine kinase FD-22. Previous work has identified this kinase as JAK1. This class of tyrosine kinases is characterized by being ubiquitously expressed, lacking both a ligand-binding domain and a SH2 domain, while containing a second domain similar to a degenerate kinase domain. Our studies focused on the further characterization of this class 3 tyrosine kinase using Northern blot analysis to demonstrate an increase in steady-state mRNA by interferon-gamma in human monocytes. A human-hamster somatic cell hybrid panel and linkage mapping was used to assign JAK1 (aml-116) to human chromosome 1. C1 NCI,FREDERICK CANC RES & DEV CTR,VIRAL CARCINOGENESIS LAB,FREDERICK,MD 21701. NCI,FREDERICK CANC RES & DEV CTR,BIOL RESPONSE MODIFIERS PROGRAM,FREDERICK,MD 21701. WALTER REED ARMY MED CTR,DEPT CELLULAR IMMUNOL,WASHINGTON,DC 20307. RP HOWARD, OMZ (reprint author), NCI,PROGRAM RESOURCES INC DYNCORP,FREDERICK CANC RES & DEV CTR,FREDERICK,MD 21701, USA. RI Dean, Michael/G-8172-2012; Howard, O M Zack/B-6117-2012 OI Dean, Michael/0000-0003-2234-0631; Howard, O M Zack/0000-0002-0505-7052 FU NCI NIH HHS [N01-CO-74102] NR 28 TC 14 Z9 14 U1 0 U2 0 PU STOCKTON PRESS PI BASINGSTOKE PA HOUNDMILLS, BASINGSTOKE, HAMPSHIRE, ENGLAND RG21 6XS SN 0950-9232 J9 ONCOGENE JI Oncogene PD MAY PY 1992 VL 7 IS 5 BP 895 EP 900 PG 6 WC Biochemistry & Molecular Biology; Oncology; Cell Biology; Genetics & Heredity SC Biochemistry & Molecular Biology; Oncology; Cell Biology; Genetics & Heredity GA HP642 UT WOS:A1992HP64200008 PM 1373877 ER PT J AU KUMAR, BVKV MAHALANOBIS, A SONG, SW SIMS, SRF EPPERSON, JF AF KUMAR, BVKV MAHALANOBIS, A SONG, SW SIMS, SRF EPPERSON, JF TI MINIMUM SQUARED ERROR SYNTHETIC DISCRIMINANT FUNCTIONS SO OPTICAL ENGINEERING LA English DT Article DE INFORMATION PROCESSING; SYNTHETIC DISCRIMINANT FUNCTION; MATCHED FILTERS ID SELECTION; FILTERS AB A new synthetic discriminant function (SDF) design approach is presented that yields the best approximation of arbitrary output correlation shapes in the minimum squared error (MSE) sense. We term such filters as MSE-SDFs. Simulation results are presented to illustrate the advantages of MSE-SDFs. Also, we show that MSE-SDFs generalize minimum average correlation energy filters. C1 MARTIN MARIETTA ELECTR SYST,ORLANDO,FL 32828. USA,MISSILE COMMAND,CTR RES DEV & ENGN,REDSTONE ARSENAL,AL 35898. UNIV ALABAMA,DEPT MATH SCI,HUNTSVILLE,AL 35899. RP KUMAR, BVKV (reprint author), CARNEGIE MELLON UNIV,DEPT ELECT & COMP ENGN,PITTSBURGH,PA 15213, USA. NR 14 TC 26 Z9 26 U1 0 U2 2 PU SOC PHOTO-OPT INSTRUM ENG PI BELLINGHAM PA PO BOX 10, BELLINGHAM, WA 98227-0010 SN 0091-3286 J9 OPT ENG JI Opt. Eng. PD MAY PY 1992 VL 31 IS 5 BP 915 EP 922 PG 8 WC Optics SC Optics GA HU370 UT WOS:A1992HU37000006 ER EF