FN Thomson Reuters Web of Science™ VR 1.0 PT J AU MEISEL, LV AF MEISEL, LV TI PERIMETER AREA ANALYSIS, THE SLIT-ISLAND METHOD AND THE FRACTAL CHARACTERIZATION OF METALLIC FRACTURE SURFACES SO JOURNAL OF PHYSICS D-APPLIED PHYSICS LA English DT Article ID DIMENSION; TOUGHNESS AB Two recent papers have raised serious questions regarding the fractal characterization of metallic fracture surfaces. The results of perimeter-area analysis and the slit-island method (SIM), in particular, are cast into doubt. In this paper perimeter-area and perimeter-yardstick analysis of rectifiable curves and of mathematically constructed, simple fractal curves are presented, in order to confront some of the questions raised. The results also serve to clarify various features of experimental fractal surface analysis. Although the present analysis cannot unambiguously resolve all the questions raised, strong support for the original fractal picture is presented and techniques for improving the SIM are suggested. RP MEISEL, LV (reprint author), CLOSE COMBAT ARMAMENT CTR,CTR RES DEV & ENGN,BENET LABS,WATERVLIET,NY 12189, USA. NR 12 TC 24 Z9 25 U1 1 U2 1 PU IOP PUBLISHING LTD PI BRISTOL PA TECHNO HOUSE, REDCLIFFE WAY, BRISTOL, ENGLAND BS1 6NX SN 0022-3727 J9 J PHYS D APPL PHYS JI J. Phys. D-Appl. Phys. PD JUN 14 PY 1991 VL 24 IS 6 BP 942 EP 952 DI 10.1088/0022-3727/24/6/020 PG 11 WC Physics, Applied SC Physics GA FT521 UT WOS:A1991FT52100020 ER PT J AU REDFIELD, RR BIRX, DL KETTER, N TRAMONT, E POLONIS, V DAVIS, C BRUNDAGE, JF SMITH, G JOHNSON, S FOWLER, A WIERZBA, T SHAFFERMAN, A VOLVOVITZ, F OSTER, C BURKE, DS AF REDFIELD, RR BIRX, DL KETTER, N TRAMONT, E POLONIS, V DAVIS, C BRUNDAGE, JF SMITH, G JOHNSON, S FOWLER, A WIERZBA, T SHAFFERMAN, A VOLVOVITZ, F OSTER, C BURKE, DS TI A PHASE-I EVALUATION OF THE SAFETY AND IMMUNOGENICITY OF VACCINATION WITH RECOMBINANT GP160 IN PATIENTS WITH EARLY HUMAN-IMMUNODEFICIENCY-VIRUS INFECTION SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Article ID SEROPOSITIVE INDIVIDUALS; HIV INFECTION; VIRAL ENVELOPE; LYMPHOCYTES-T; HTLV-III; AIDS; ANTIBODIES; TYPE-1; NEUTRALIZATION; GP120 AB Background. Despite multiple antiviral humoral and cellular immune responses, infection with the human immunodeficiency virus (HIV) results in a progressively debilitating disease. We hypothesized that a more effective immune response could be generated by post-infection vaccination with HIV-specific antigens. Methods. We performed a phase I trial of the safety and immunogenicity of a vaccine prepared from molecularly cloned envelope protein, gp160, in 30 volunteer subjects with HIV infection in Walter Reed stage 1 or 2. The vaccine was administered either on days 0, 30, and 120 or on days 0, 30, 60, 120, 150, and 180. HIV-specific humoral and cellular immune responses were measured; local and systemic reactions to vaccination, including general measures of immune function, were monitored. Results. In 19 of the 30 subjects both humoral and cellular immunity to HIV envelope proteins increased in response to vaccination with gp160. Seroconversion to selected envelope epitopes was observed, as were new T-cell proliferative responses to gp160. Response was associated with the CD4 cell count determined before vaccination (13 of 16 subjects [81 percent] with > 600 cells per milliliter responded, as compared with 6 of 14 [43 percent] with less-than-or-equal-to 600 cells per milliliter; P = 0.07) and with the number of injections administered (87 percent of subjects randomly assigned to receive six injections responded, as compared with 40 percent of those assigned to three injections; P = 0.02). Local reactions at the site of injection were mild. There were no adverse systemic reactions, including diminution of general in vitro or in vivo cellular immune function. After 10 months of follow-up, the mean CD4 count had not decreased in the 19 subjects who responded, but it had decreased by 7.3 percent in the 11 who did not respond. Conclusions. This gp160 vaccine is safe and immunogenic in volunteer patients with early HIV infection. Although it is too early to know whether this approach will be clinically useful, further scientific and therapeutic evaluation of HIV-specific vaccine therapy is warranted. Similar vaccines may prove to be effective for other chronic infections. C1 ISRAEL INST BIOL RES,DEPT BIOCHEM,IL-70450 NESS ZIONA,ISRAEL. HENRY M JACKSON FDN ADVANCEMENT MIL MED,ROCKVILLE,MD. MICROGENESYS INC,MERIDEN,CT. WALTER REED ARMY MED CTR,DEPT MED,INFECT DIS SERV,WASHINGTON,DC 20307. SRA TECHNOL INC,ROCKVILLE,MD. WALTER REED ARMY MED CTR,DIV RETROVIROL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DIV PREVENT MED,WASHINGTON,DC 20307. RP REDFIELD, RR (reprint author), WALTER REED ARMY MED CTR,DEPT RETROVIRAL RES,13 TAFT CT,ROCKVILLE,MD 20850, USA. OI /0000-0002-5704-8094 NR 54 TC 240 Z9 241 U1 1 U2 3 PU MASS MEDICAL SOC PI BOSTON PA 10 SHATTUCK, BOSTON, MA 02115 SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD JUN 13 PY 1991 VL 324 IS 24 BP 1677 EP 1684 DI 10.1056/NEJM199106133242401 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA FQ155 UT WOS:A1991FQ15500001 PM 1674589 ER PT J AU FARR, WD AF FARR, WD TI THE SOUTH INFLAMED - THE CASE OF WIRZ,HENRY SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Letter RP FARR, WD (reprint author), USA,SAN ANTONIO,TX, USA. NR 6 TC 0 Z9 0 U1 1 U2 1 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD JUN 12 PY 1991 VL 265 IS 22 BP 2960 EP 2960 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA FP635 UT WOS:A1991FP63500024 ER PT J AU XIE, JG RUEKGAUER, TE ARMSTRONG, RL PINNICK, RG AF XIE, JG RUEKGAUER, TE ARMSTRONG, RL PINNICK, RG TI EVAPORATIVE INSTABILITY IN PULSED LASER-HEATED DROPLETS SO PHYSICAL REVIEW LETTERS LA English DT Article ID EXPLOSIVE VAPORIZATION; BREAKDOWN THRESHOLDS; SUPERHEAT LIMIT; CO2-LASER; DYNAMICS; LIQUID; WATER AB First observations of an evaporative instability in absorptive dye (Nigrosin) doped water droplets heated by a pulsed Nd:YAlG laser (532 nm) are reported. Measurement of the instability thresholds at different dye concentrations shows an approximate inverse linear dependence on droplet absorption index, suggesting that the instability is caused by superheating of the droplet. The instability may trigger subsequent droplet deformation or disintegration; however, below a well-defined fluence threshold, complete recovery of the droplet occurs following laser excitation. A qualitative model based on Landau instability theory is used to describe the instability. C1 ATMOSPHER SCI LAB,WHITE SANDS MISSILE RANGE,NM 88002. RP XIE, JG (reprint author), NEW MEXICO STATE UNIV,DEPT PHYS,LAS CRUCES,NM 88003, USA. NR 17 TC 8 Z9 8 U1 0 U2 3 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0031-9007 J9 PHYS REV LETT JI Phys. Rev. Lett. PD JUN 10 PY 1991 VL 66 IS 23 BP 2988 EP 2991 DI 10.1103/PhysRevLett.66.2988 PG 4 WC Physics, Multidisciplinary SC Physics GA FP871 UT WOS:A1991FP87100013 ER PT J AU COWAN, DN BRUNDAGE, JF POMERANTZ, RS MILLER, RN BURKE, DS AF COWAN, DN BRUNDAGE, JF POMERANTZ, RS MILLER, RN BURKE, DS TI HIV-INFECTION AMONG MEMBERS OF THE UNITED-STATES-ARMY RESERVE COMPONENTS WITH MEDICAL AND HEALTH OCCUPATIONS SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Article ID MARITAL-STATUS; CANCER; RISK; MEN; AIDS; PREVALENCE AB Over 58 000 members of the US Army Reserve Components tested for human immunodeficiency virus (HIV) antibody had military or civilian medical occupations. The availability of HIV status and occupational information permits the assessment of prevalence and incidence of infection in this population. Levels of infection were not higher among women or among currently married men with medical occupations compared with those with nonmedical occupations. Prevalence and incidence were elevated among never-married men with either military or civilian medical occupations compared with never-married men with nonmedical occupations. Based on reported civilian occupation, male registered nurses and men with other medical occupations, excluding physicians and dentists, had a significantly higher prevalence of infection than men with nonmedical occupations. The patterns of infection suggest that the higher levels of infection found among never-married men with medical occupations may not be entirely due to occupational exposure. These findings may have applications in the design and interpretation of results of health care worker HIV surveillance programs. C1 WALTER REED ARMY MED CTR,DIV RETROVIROL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DIV PREVENT MED,WASHINGTON,DC 20307. RP COWAN, DN (reprint author), SRA TECHNOL INC,4700 KING ST,SUITE 300,ALEXANDRIA,VA 22302, USA. NR 25 TC 19 Z9 20 U1 2 U2 2 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD JUN 5 PY 1991 VL 265 IS 21 BP 2826 EP 2830 DI 10.1001/jama.265.21.2826 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA FN855 UT WOS:A1991FN85500031 PM 2033739 ER PT J AU OCKENHOUSE, CF KLOTZ, FW TANDON, NN JAMIESON, GA AF OCKENHOUSE, CF KLOTZ, FW TANDON, NN JAMIESON, GA TI USE OF ANTIIDIOTYPE ANTIBODIES TO ISOLATE SEQUESTRIN, A 270-KDA PROTEIN ON THE SURFACE OF MALARIA-INFECTED RED-CELLS THAT MEDIATES THEIR ADHERENCE TO GPIV (CD36) SO THROMBOSIS AND HAEMOSTASIS LA English DT Meeting Abstract C1 INST RES,WASHINGTON,DC. AMER RED CROSS,CELL BIOL LAB,ROCKVILLE,MD. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU F K SCHATTAUER VERLAG GMBH PI STUTTGART PA P O BOX 10 45 45, LENZHALDE 3, D-70040 STUTTGART, GERMANY SN 0340-6245 J9 THROMB HAEMOSTASIS JI Thromb. Haemost. PD JUN 5 PY 1991 VL 65 IS 6 BP 810 EP 810 PG 1 WC Hematology; Peripheral Vascular Disease SC Hematology; Cardiovascular System & Cardiology GA FZ966 UT WOS:A1991FZ96600452 ER PT J AU VELOSO, D CAMPBELL, G AF VELOSO, D CAMPBELL, G TI COMPUTERIZED IMMUNOBLOT ANALYSES OF THE DISTRIBUTION OF PREKALLIKREIN AND ITS ACTIVATION PRODUCTS IN NORMAL AND C1 INHIBITOR-DEFICIENT HUMAN PLASMAS SO THROMBOSIS AND HAEMOSTASIS LA English DT Meeting Abstract C1 USA,MED RES INST INFECT DIS,DIV MED,FREDERICK,MD 21702. GRAD HOSP PHILADELPHIA,PHILADELPHIA,PA 19146. NR 0 TC 1 Z9 1 U1 0 U2 0 PU F K SCHATTAUER VERLAG GMBH PI STUTTGART PA P O BOX 10 45 45, LENZHALDE 3, D-70040 STUTTGART, GERMANY SN 0340-6245 J9 THROMB HAEMOSTASIS JI Thromb. Haemost. PD JUN 5 PY 1991 VL 65 IS 6 BP 1316 EP 1316 PG 1 WC Hematology; Peripheral Vascular Disease SC Hematology; Cardiovascular System & Cardiology GA FZ966 UT WOS:A1991FZ96602253 ER PT J AU GERBER, N SEDNEY, R AF GERBER, N SEDNEY, R TI STUDY OF WAKE OPTICAL-PROPERTIES SO AIAA JOURNAL LA English DT Note RP GERBER, N (reprint author), USA,BALLIST RES LABS,DIV LAUNCH & FLIGHT,ABERDEEN PROVING GROUND,MD 21005, USA. NR 4 TC 0 Z9 0 U1 0 U2 0 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091 SN 0001-1452 J9 AIAA J JI AIAA J. PD JUN PY 1991 VL 29 IS 6 BP 1005 EP 1006 DI 10.2514/3.10694 PG 2 WC Engineering, Aerospace SC Engineering GA FU410 UT WOS:A1991FU41000026 ER PT J AU VIECHNICKI, DJ SLAVIN, MJ KLIMAN, MI AF VIECHNICKI, DJ SLAVIN, MJ KLIMAN, MI TI DEVELOPMENT AND CURRENT STATUS OF ARMOR CERAMICS SO AMERICAN CERAMIC SOCIETY BULLETIN LA English DT Article ID DYNAMIC YIELD RP VIECHNICKI, DJ (reprint author), USA,MAT TECHNOL LAB,WATERTOWN,MA 02172, USA. NR 20 TC 47 Z9 47 U1 1 U2 6 PU AMER CERAMIC SOC PI WESTERVILLE PA 735 CERAMIC PLACE, PO BOX 6136, WESTERVILLE, OH 43081-6136 SN 0002-7812 J9 AM CERAM SOC BULL JI Am. Ceram. Soc. Bull. PD JUN PY 1991 VL 70 IS 6 BP 1035 EP 1039 PG 5 WC Materials Science, Ceramics SC Materials Science GA FQ167 UT WOS:A1991FQ16700012 ER PT J AU BAKER, WJ HARGIS, JB DANESI, R LAROCCA, RV AF BAKER, WJ HARGIS, JB DANESI, R LAROCCA, RV TI THE EFFECT OF RHGM-CSF ON THE PROLIFERATION OF OSTEOGENIC-SARCOMA CELLS SO AMERICAN JOURNAL OF HEMATOLOGY LA English DT Article DE GM-CSF; OSTEOSARCOMA; CELL GROWTH ID COLONY-STIMULATING FACTOR; HEMATOPOIETIC GROWTH-FACTORS; TUMOR-CELLS; GM-CSF; CARCINOMA; LEUKEMIA; LINES AB Recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) promotes the growth of a variety of hematopoietic and nonhematopoietic cells, both benign and malignant. There is now evidence that osteoblast-like cells produce GM-CSF and their growth is stimulated by this cytokine in vitro. We have studied the effect of rhGM-CSF on DNA synthesis and cell proliferation in the human osteogenic sarcoma cell lines U-20S, G-292, MG-63, and HOS. RhGM-CSF stimulated a dose-dependent increase in radioactive thymidine incorporation in each of the four cell lines in the presence of serum-free media, and in two cell lines (HOS and U-20S) in the presence of fetal bovine serum (FBS). In addition, rhGM-CSF produced significant increases in cell proliferation in two cell lines (MG-63 and U-20S) in the presence of 2% FBS. These results suggest that GM-CSF may have an important role in the biology of human osteogenic sarcoma cells. The clinical implications of these findings merit further investigation. C1 WALTER REED ARMY MED CTR,DEPT MED,DIV HEMATOL ONCOL,WASHINGTON,DC 20307. NCI,CLIN ONCOL PROGRAM,MED BRANCH,BETHESDA,MD 20892. NR 17 TC 6 Z9 6 U1 0 U2 1 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0361-8609 J9 AM J HEMATOL JI Am. J. Hematol. PD JUN PY 1991 VL 37 IS 2 BP 84 EP 87 DI 10.1002/ajh.2830370205 PG 4 WC Hematology SC Hematology GA FM888 UT WOS:A1991FM88800004 PM 2069168 ER PT J AU PIERSON, JF HINER, WO AF PIERSON, JF HINER, WO TI TIME REQUIREMENTS ASSOCIATED WITH 3 PHARMACY INVENTORY-CONTROL METHODS SO AMERICAN JOURNAL OF HOSPITAL PHARMACY LA English DT Note C1 WALTER REED ARMY MED CTR,SERV PHARM,WASHINGTON,DC 20307. RP PIERSON, JF (reprint author), USA,MEDDAC,PHARM SERV,APO,NEW YORK,NY 09801, USA. NR 3 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC HEALTH-SYSTEM PHARMACISTS PI BETHESDA PA 7272 WISCONSIN AVE, BETHESDA, MD 20814 SN 0002-9289 J9 AM J HOSP PHARM JI Am. J. Hosp. Pharm. PD JUN PY 1991 VL 48 IS 6 BP 1259 EP 1260 PG 2 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA FN806 UT WOS:A1991FN80600022 PM 1858807 ER PT J AU SCHULZE, TL TAYLOR, RC TAYLOR, GC BOSLER, EM AF SCHULZE, TL TAYLOR, RC TAYLOR, GC BOSLER, EM TI LYME-DISEASE - A PROPOSED ECOLOGICAL INDEX TO ASSESS AREAS OF RISK IN THE NORTHEASTERN UNITED-STATES SO AMERICAN JOURNAL OF PUBLIC HEALTH LA English DT Article ID IXODES-DAMMINI ACARI; AMBLYOMMA-AMERICANUM ACARI; NEW-JERSEY; IXODIDAE; TICKS; USA; SPIROCHETE; DEER AB Background: Recent public awareness has resulted in a demand for information about ways to reduce the risk of acquiring Lyme disease. Methods: Twenty-two school properties and recreational areas within a Lyme disease endemic area of central Monmouth County, New Jersey were evaluated for risk of transmission using an ecological index on the suitability, amount, and access to Ixodes dammini habitat by target human populations and the abundance of infected adult ticks. Results: The characterization of tick habitat accurately predicted the elimination of 11 sites from concern. Of the remaining 11 sites, six were classified high risk and five as moderate risk. On-site tick surveys identified infected I. dammini adults at only four sites (three risk; one moderate risk). Conclusions: These results indicate that the use of selected ecological parameters provides a cost-effective method to rapidly identify areas at risk for Lyme disease transmission. C1 FREEHOLD TOWNSHIP HLTH DEPT,FREEHOLD,NJ. SUNY STONY BROOK,HLTH SCI CTR,NEW YORK STATE DEPT HLTH,STONY BROOK,NY 11794. USA,MED DEPT ACTIV,PREVENT MED SERV,ENVIRONM HLTH SECT,FT MONMOUTH,NJ 07703. RP SCHULZE, TL (reprint author), NEW JERSEY STATE DEPT HLTH,DIV EPIDEMIOL & DIS CONTROL,CN 369,3635 QUAKERBRIDGE RD,TRENTON,NJ 08625, USA. NR 11 TC 35 Z9 37 U1 0 U2 5 PU AMER PUBLIC HEALTH ASSN INC PI WASHINGTON PA 1015 FIFTEENTH ST NW, WASHINGTON, DC 20005 SN 0090-0036 J9 AM J PUBLIC HEALTH JI Am. J. Public Health PD JUN PY 1991 VL 81 IS 6 BP 714 EP 718 DI 10.2105/AJPH.81.6.714 PG 5 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA FV607 UT WOS:A1991FV60700008 PM 2029039 ER PT J AU SHANLEY, DJ DAUMKOWALSKI, R EMBRY, RL AF SHANLEY, DJ DAUMKOWALSKI, R EMBRY, RL TI ADENOID CYSTIC CARCINOMA OF THE AIRWAY - MR FINDINGS SO AMERICAN JOURNAL OF ROENTGENOLOGY LA English DT Letter ID TRACHEA RP SHANLEY, DJ (reprint author), TRIPLER ARMY MED CTR,HONOLULU,HI 96859, USA. NR 2 TC 1 Z9 1 U1 0 U2 0 PU AMER ROENTGEN RAY SOC PI RESTON PA 1891 PRESTON WHITE DR SUBSCRIPTION FULFILLMENT, RESTON, VA 22091 SN 0361-803X J9 AM J ROENTGENOL JI Am. J. Roentgenol. PD JUN PY 1991 VL 156 IS 6 BP 1321 EP 1322 PG 2 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA FM539 UT WOS:A1991FM53900059 PM 1851382 ER PT J AU MILLS, JN ELLIS, BA MCKEE, KT KSIAZEK, TG ORO, JGB MAIZTEGUI, JI CALDERON, GE PETERS, CJ CHILDS, JE AF MILLS, JN ELLIS, BA MCKEE, KT KSIAZEK, TG ORO, JGB MAIZTEGUI, JI CALDERON, GE PETERS, CJ CHILDS, JE TI JUNIN VIRUS ACTIVITY IN RODENTS FROM ENDEMIC AND NONENDEMIC LOCI IN CENTRAL ARGENTINA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID EXPERIMENTAL-INFECTION; PROGRESSIVE EXTENSION; HEMORRHAGIC-FEVER; ANTIBODIES; AREA AB Small mammals were trapped during a 21-month period at 27 farm sites in 15 localities within and beyond the known endemic area for Argentine hemorrhagic fever (AHF). Prevalence of Junin virus (JV) was assessed by antigen-capture enzyme immunoassay (ELISA) on samples of body fluids and/or organs from 3, 282 captured rodents. Infection in rodent populations was variable (0-3.7%) among localities but, in all cases, was lower than previously reported rates. Overall prevalence was 1.4% in the AHF epidemic area, 0.6% in the historic (currently low incidence of AHF) area, and 0.4% in two localities beyond the previously defined endemic area. These low values underestimate the actual prevalence of JV, as ELISA validation by virus isolation indicated a sensitivity of 30% and a specificity of 99%. Of 37 positive rodents, 28 (76%) were of two species: Calomys musculinus (23 animals) and C. laucha (5 animals). Antigen also was found in three Akodon azarae, four Bolomys obscurus, one Mus musculus, and one Oxymycterus rufus, and JV was isolated from two Oligoryzomys flavescens. Three of these rodent species (B. obscurus, O. flavescens, and O. rufus) have heretofore not been implicated in JV maintenance in the field. Evidence suggests that the AHF endemic area may continue to expand northward. C1 JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,DEPT IMMUNOL & INFECT DIS,615 N WOLFE ST,BALTIMORE,MD 21205. USA,MED RES INST INFECT DIS,FREDERICK,MD 21702. SALK INST,DIV GOVT SERV,SWIFTWATER,PA 18370. INST NACL ESTUDIOS VIROSIS HEMORRAG,RA-2700 PERGAMINO,BUENOS AIRES,ARGENTINA. RI Childs, James/B-4002-2012 NR 25 TC 50 Z9 54 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JUN PY 1991 VL 44 IS 6 BP 589 EP 597 PG 9 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA GA229 UT WOS:A1991GA22900005 PM 1650148 ER PT J AU KLEIN, TA LIMA, JBP TADA, MS AF KLEIN, TA LIMA, JBP TADA, MS TI COMPARATIVE SUSCEPTIBILITY OF ANOPHELINE MOSQUITOS TO PLASMODIUM-FALCIPARUM IN RONDONIA, BRAZIL SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID MALARIA; AREAS; STATE AB Five anopheline species, Anopheles deaneorum, An. albitarsis, An. triannulatus, An. oswaldoi, and An. mediopunctatus were compared to An. darlingi for susceptibility to infection by P. falciparum in Costa Marques, Rondonia, Brazil. Laboratory reared F1 An. darlingi and anopheline test species were allowed to feed at the same time on falciparum malaria patients who had gametocytes in their blood, and who had not yet been treated with quinine. Mosquitoes were dissected and examined for oocyts on day 9, and for sporozoites on days 16-20 after feeding. Anopheles mediopunctatus had higher mean numbers of oocysts and oocyst positive rates than An. darlingi. The oocyst positive rate and the mean number of oocysts in An. deaneorum and An. darlingi were similar. Anopheles triannulatus and An. oswaldoi had fewer oocysts than An. darlingi. The salivary gland sporozoite infection rate was similar for An. mediopunctatus and An. deaneorum and much lower for An. triannulatus and An. oswaldoi when compared to An. darlingi. Anopheles albitarsis developed oocysts, but sporozoites did not invade the salivary glands. In relative levels of susceptibility to P. falciparum, An. darlingi was equal to An. mediopunctatus which was greater than An. deaneorum, which was greater than An. triannulatus, which was greater than An. oswaldoi. C1 USA,MED RES UNIT BRAZIL,AMER CONSULATE RIO,APO,MIAMI,FL 34030. SECRETARIA ESTADADO RONDONIA,UNIDADE MISTA COSTA MARQUES,BR-78975 COSTA MARQUES,RONDONIA,BRAZIL. UNIV BRASILIA,BR-70910 BRASILIA,DF,BRAZIL. NR 16 TC 66 Z9 70 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JUN PY 1991 VL 44 IS 6 BP 598 EP 603 PG 6 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA GA229 UT WOS:A1991GA22900006 PM 1858963 ER PT J AU KLEIN, TA TADA, MS LIMA, JBP AF KLEIN, TA TADA, MS LIMA, JBP TI INFECTION OF ANOPHELES-DARLINGI FED ON PATIENTS WITH PLASMODIUM-FALCIPARUM BEFORE AND AFTER TREATMENT WITH QUININE OR QUININE PLUS TETRACYCLINE SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID CHLOROQUINE-RESISTANT; GAMETOCYTES; MALARIA AB Anopheles darlingi fed on eight falciparum malaria patients with gametocytes before and after treatment with quinine sulfate or quinine sulfate plus tetracycline became infected. Quinine and quinine plus tetracycline had no apparent sporontocidal or gametocytocidal effect on late stage immature and mature gametocytes. Plasmodium falciparum gametocytes are persistent and infected mosquitoes for up to 21 days after patients were treated with quinine plus tetracycline. Sporogonic development was similar for groups of mosquitoes fed before and after patients were treated with these schizontocides. The percentages of infected mosquitoes that developed salivary gland infections were also similar for groups of mosquitoes fed before and after treatment. Twenty-four hours after treatment with 45 mg of primaquine phosphate, falciparum malaria patients were not infective to An. darlingi. C1 SECRETARIA ESTADO RONDONIA,UNIDADE MISTA COSTA MARQUES,COSTA MARQUES,RONDONIA,BRAZIL. USA,MED RES UNIT BRAZIL,AMER CONSULATE RIO,APO,MIAMI,FL 34030. UNIV BRASILIA,BR-70910 BRASILIA,DF,BRAZIL. NR 19 TC 13 Z9 13 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JUN PY 1991 VL 44 IS 6 BP 604 EP 608 PG 5 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA GA229 UT WOS:A1991GA22900007 PM 1858964 ER PT J AU PROCELL, P BATHURST, IC LOWELL, G RUEBUSH, TK SKINNER, JC HIGHTOWER, AW COLLINS, WE AF PROCELL, P BATHURST, IC LOWELL, G RUEBUSH, TK SKINNER, JC HIGHTOWER, AW COLLINS, WE TI CELLULAR PROLIFERATIVE RESPONSES IN SQUIRREL-MONKEYS IMMUNIZED WITH RECOMBINANT AND SYNTHETIC PLASMODIUM-VIVAX CIRCUMSPOROZOITE PEPTIDES SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID FALCIPARUM-MALARIA; T-CELLS; VACCINE DEVELOPMENT; SPOROZOITES; PROTEIN; EPITOPE; ANTIBODIES; ANTIGEN; INTERFERON; SAFETY AB The role of circulating peripheral blood momonuclear cells (PBMC) in mediating protective immunity was examined during an immunization trial in Saimiri monkeys. Three engineered constructs representing different but overlapping regions of the circumsporozoite (CS) protein of Plasmodium vivax were used to immunize the Saimiri monkeys. Monkeys were randomly placed into three immunization groups: rPvCS2, rPvCS3, and LCV3 (representing three different but overlapping portions of the P. vivax CS protein) and two control groups: an alum adjuvant control group and an unimmunized control group. Collections of PBMC were made throughout the study at weeks 0, 2, 8, challenge (week 16), and two weeks after challenge. Proliferative responses to all immunogens and pokeweed mitogen were measured in all monkeys. Fourteen of 18 monkeys immunized with either rPvCS2 or rPvCS3 responded on the day of challenge to the appropriate immunogen with a stimulation index > 2. Immunization with LCV3, which represents the repeat region only, elicited a specific response in only one monkey. However, monkeys in both control groups also responded to rPvCS2 and rPvCS3, regardless of immunization, suggesting the presence of epitopes in rPvCS2 and rPvCS3 capable of associating with differing MHC antigens. Furthermore, the frequency of these cells in the periphery was increased by immunization, as demonstrated by a greater number of responding monkeys in the rPvCS2 and rPvCS3 immunized groups. C1 CTR DIS CONTROL,CTR INFECT DIS,DIV PARASIT DIS,OFF DIRECTOR,ATLANTA,GA 30333. CHIRON CORP,EMERYVILLE,CA 94608. WALTER REED ARMY MED CTR,DEPT IMMUNOL,WASHINGTON,DC 20307. RP PROCELL, P (reprint author), CTR DIS CONTROL,MALARIA BRANCH,ATLANTA,GA 30333, USA. NR 23 TC 6 Z9 6 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JUN PY 1991 VL 44 IS 6 BP 632 EP 639 PG 8 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA GA229 UT WOS:A1991GA22900010 PM 1858966 ER PT J AU KREUTZER, RD CORREDOR, A GRIMALDI, G GROGL, M ROWTON, ED YOUNG, DG MORALES, A MCMAHONPRATT, D GUZMAN, H TESH, RB AF KREUTZER, RD CORREDOR, A GRIMALDI, G GROGL, M ROWTON, ED YOUNG, DG MORALES, A MCMAHONPRATT, D GUZMAN, H TESH, RB TI CHARACTERIZATION OF LEISHMANIA-COLOMBIENSIS SP-N (KINETOPLASTIDA, TRYPANOSOMATIDAE), A NEW PARASITE INFECTING HUMANS, ANIMALS, AND PHLEBOTOMINE SAND FLIES IN COLOMBIA AND PANAMA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID SPECIES-SPECIFIC DETERMINANTS; MONOCLONAL-ANTIBODIES; AMAZONIAN BRAZIL; PSYCHODIDAE; DIPTERA; DONOVANI; AMERICA; STAGE AB Characterization of Leishmania colombiensis sp.n. is presented, which on the basis of biological and molecular criteria, appears to be a new member of the L. braziliensis complex. A total of nine isolates of the new parasite were made in Colombia and Panama between 1980 and 1986: two from human cases of cutaneous leishmaniasis, six from phlebotomine sand flies, and one from a sloth. Although most closely related to L. lainsoni, L. colombiensis sp.n. is clearly distinguishable from other members of the genus by its reactivity with monoclonal antibodies, isoenzyme electrophoresis, and restriction endonuclease fragment patterns of kinetoplast DNA (k-DNA). C1 YALE UNIV, SCH MED, DEPT EPIDEMIOL & PUBL HLTH, NEW HAVEN, CT 06510 USA. UNIV NACL COLOMBIA, FAC MED, SANTA FE DE BOGOTA, COLOMBIA. MINIST SALUD, INST NACL SALUD, SANTA FE DE BOGOTA, COLOMBIA. INST OSWALDO CRUZ, DEPT IMMUNOL, BR-20000 RIO DE JANEIRO, BRAZIL. WALTER REED ARMY MED CTR, DEPT ENTOMOL, WASHINGTON, DC 20307 USA. WALTER REED ARMY MED CTR, DIV EXPTL THERAPEUT, WASHINGTON, DC 20307 USA. UNIV FLORIDA, DEPT ENTOMOL & NEMATOL, GAINESVILLE, FL 32611 USA. RI Rowton, Edgar/A-4474-2012; Rowton, Edgar/A-1975-2011 OI Rowton, Edgar/0000-0002-1979-1485 FU NIAID NIH HHS [AI-21049, AI-23004, AI-20108] NR 29 TC 41 Z9 53 U1 0 U2 3 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA SN 0002-9637 EI 1476-1645 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JUN PY 1991 VL 44 IS 6 BP 662 EP 675 PG 14 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA GA229 UT WOS:A1991GA22900013 PM 1677544 ER PT J AU SANDLER, S AF SANDLER, S TI THE ROYAL-NAVY COASTAL CRAZE - TECHNOLOGICAL RESULTS OF STRATEGIC CONFUSION IN THE EARLY IRONCLAD ERA SO AMERICAN NEPTUNE LA English DT Article RP SANDLER, S (reprint author), USA JOHN F KENNEDY SPECIAL WARFARE CTR & SCH,FT BRAGG,NC, USA. NR 46 TC 2 Z9 2 U1 0 U2 0 PU PEABODY MUSEUM PI SALEM PA E INDIA MARINE HALL, SALEM, MA 01970 SN 0003-0155 J9 AM NEPTUNE JI Am. Neptune PD SUM PY 1991 VL 51 IS 3 BP 164 EP 172 PG 9 WC History SC History GA GP086 UT WOS:A1991GP08600004 ER PT J AU SINGH, K SHANKS, GD WILDE, H AF SINGH, K SHANKS, GD WILDE, H TI SEIZURES AFTER MEFLOQUINE SO ANNALS OF INTERNAL MEDICINE LA English DT Letter C1 ARMED FORCES RES INST MED SCI,BANGKOK 10400,THAILAND. CHULALONGKORN UNIV,BANGKOK 10400,THAILAND. RP SINGH, K (reprint author), BANGKOK GEN HOSP,BANGKOK 10400,THAILAND. NR 5 TC 10 Z9 10 U1 0 U2 0 PU AMER COLL PHYSICIANS PI PHILADELPHIA PA INDEPENDENCE MALL WEST 6TH AND RACE ST, PHILADELPHIA, PA 19106-1572 SN 0003-4819 J9 ANN INTERN MED JI Ann. Intern. Med. PD JUN 1 PY 1991 VL 114 IS 11 BP 994 EP 994 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA FM979 UT WOS:A1991FM97900026 PM 2024874 ER PT J AU CIOFFI, WG RUE, LW GRAVES, TA MCMANUS, WF MASON, AD PRUITT, BA AF CIOFFI, WG RUE, LW GRAVES, TA MCMANUS, WF MASON, AD PRUITT, BA TI PROPHYLACTIC USE OF HIGH-FREQUENCY PERCUSSIVE VENTILATION IN PATIENTS WITH INHALATION INJURY SO ANNALS OF SURGERY LA English DT Article; Proceedings Paper CT 102ND ANNUAL MEETING OF THE SOUTHERN SURGICAL ASSOC CY DEC 03-06, 1990 CL BOCA RATON, FL SP SO SURG ASSOC ID CONVENTIONAL MECHANICAL VENTILATION; END-EXPIRATORY PRESSURE; JET VENTILATION; RESPIRATORY-FAILURE; LUNG INJURY; BRONCHIAL-SECRETIONS; OSCILLATIONS; OXYGENATION; PNEUMONIA AB Death and the incidence of pneumonia are significantly increased in burn patients with inhalation injury, despite application of conventional ventilatory support techniques. The effect of high-frequency percussive ventilation on mortality rate, incidence of pulmonary infection, and barotrauma were studied in 54 burn patients with documented inhalation injury admitted between March 1987 and September 1990 as compared to an historic cohort treated between 1980 and 1984. All patients satisfied clinical criteria for mechanical ventilation. High-frequency percussive ventilation was initiated within 24 hours of intubation. The patients' mean age and burn size were 32.2 years and 47.8%, respectively (ranges, 15 to 88 years; 0% to 90%). The mean number of ventilator days was 15.3 +/- 16.7 (range, 1 to 150 days), with 26% of patients ventilated for more than 2 weeks. Fourteen patients (25.9%) developed pneumonia compared to an historic frequency of 45.8% (p < 0.005). Mortality rate was 18.5% (10 patients) with an expected historic number of deaths of 23 (95% confidence limits of 17 to 28 deaths). The documented improvement in survival rate and decrease in the incidence of pneumonia in patients treated with prophylactic high-frequency ventilation (HFV), as compared to a cohort of patients treated in the 7 years before the trial, indicates the importance of small airway patency in the pathogenesis of inhalation injury sequelae and supports further use and evaluation of HFV. RP CIOFFI, WG (reprint author), USA,INST SURG RES,FT SAM HOUSTON,TX 78234, USA. NR 22 TC 79 Z9 79 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0003-4932 J9 ANN SURG JI Ann. Surg. PD JUN PY 1991 VL 213 IS 6 BP 575 EP 582 PG 8 WC Surgery SC Surgery GA FQ682 UT WOS:A1991FQ68200007 PM 2039288 ER PT J AU WASUNNA, KMA WERE, JBO ROMIG, T REES, PH SHERWOOD, JA AF WASUNNA, KMA WERE, JBO ROMIG, T REES, PH SHERWOOD, JA TI BACTERIAL-INFECTION OF HYDATID CYST FOLLOWING ALBENDAZOLE TREATMENT SO ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY LA English DT Note ID TURKANA DISTRICT; DISEASE; PREVALENCE; KENYA C1 KENYA GOVT MED RES CTR,CLIN RES CTR,BOX 20778,NAIROBI,KENYA. USA,HOSP MED RES UNIT KENYA,NEW YORK,NY 09675. AFRICAN MED & RES FDN,NAIROBI,KENYA. NR 4 TC 4 Z9 4 U1 0 U2 0 PU W B SAUNDERS CO LTD PI LONDON PA 24-28 OVAL RD, LONDON, ENGLAND NW1 7DX SN 0003-4983 J9 ANN TROP MED PARASIT JI Ann. Trop. Med. Parasitol. PD JUN PY 1991 VL 85 IS 3 BP 369 EP 370 PG 2 WC Public, Environmental & Occupational Health; Parasitology; Tropical Medicine SC Public, Environmental & Occupational Health; Parasitology; Tropical Medicine GA GD131 UT WOS:A1991GD13100013 PM 1746988 ER PT J AU MCNESBY, KL FIFER, RA AF MCNESBY, KL FIFER, RA TI FOURIER-TRANSFORM INFRARED-SPECTROSCOPY OF NITRIC-OXIDE DURING EXPOSURE TO VACUUM ULTRAVIOLET-RADIATION SO APPLIED SPECTROSCOPY LA English DT Article DE INFRARED SPECTROSCOPY; ION CHEMISTRY; PHOTOIONIZATION AB The FT-IR spectrum of chemically pure (C.P.) NO was obtained while the gas was being irradiated by radiation at 121.5 nm. A novel cell design allows the ultraviolet radiation and the infrared probe beam to be co-linear. The exposure time of the gas to the UV radiation ranged from 0 to 100 minutes. Spectra were collected at evenly spaced time intervals during irradiation by the UV radiation. The composition of the gas changed as a function of irradiation time. Experimental results were compared with the calculated change in the composition of the gas by solving a set of simultaneous differential equations based on a kinetic model, giving good agreement. It is shown that the cell may also be used as an actinometer, and may be used as a check on the applicability of some rate equations to reacting systems. RP MCNESBY, KL (reprint author), USA,BALLIST RES LABS,SLCBR-IB-I,ABERDEEN PROVING GROUND,MD 21005, USA. NR 17 TC 0 Z9 0 U1 0 U2 1 PU SOC APPLIED SPECTROSCOPY PI FREDERICK PA PO BOX 1438, FREDERICK, MD 21701 SN 0003-7028 J9 APPL SPECTROSC JI Appl. Spectrosc. PD JUN PY 1991 VL 45 IS 5 BP 906 EP 910 DI 10.1366/0003702914336615 PG 5 WC Instruments & Instrumentation; Spectroscopy SC Instruments & Instrumentation; Spectroscopy GA FV083 UT WOS:A1991FV08300028 ER PT J AU MCQUAID, MJ SAUSA, RC AF MCQUAID, MJ SAUSA, RC TI ABSORPTION CROSS-SECTIONS OF GASEOUS DIMETHYLNITRAMINE AT SELECTED WAVELENGTHS BETWEEN 185 AND 325 NM SO APPLIED SPECTROSCOPY LA English DT Note DE UV SPECTROSCOPY; DIMETHYLNITRAMINE; ABSORPTION CROSS SECTIONS ID LASER PYROLYSIS C1 USA,BALLIST RES LABS,SLCBR IB-I,ABERDEEN PROVING GROUND,MD 21005. NR 14 TC 14 Z9 14 U1 1 U2 1 PU SOC APPLIED SPECTROSCOPY PI FREDERICK PA PO BOX 1438, FREDERICK, MD 21701 SN 0003-7028 J9 APPL SPECTROSC JI Appl. Spectrosc. PD JUN PY 1991 VL 45 IS 5 BP 916 EP 917 DI 10.1366/0003702914336507 PG 2 WC Instruments & Instrumentation; Spectroscopy SC Instruments & Instrumentation; Spectroscopy GA FV083 UT WOS:A1991FV08300030 ER PT J AU SAMLASKA, CP AF SAMLASKA, CP TI PROTEIN-C AND PROTEIN-S PLASMA-LEVELS IN PATIENTS WITH LIPODERMATOSCLEROSIS AND VENOUS ULCERATION SO ARCHIVES OF DERMATOLOGY LA English DT Letter ID SUPERFICIAL THROMBOPHLEBITIS; HYPERCOAGULABLE STATES; SKIN NECROSIS; DEFICIENCY; COUMARIN RP SAMLASKA, CP (reprint author), TRIPLER ARMY MED CTR,DERMATOL SERV,HONOLULU,HI 96859, USA. NR 9 TC 3 Z9 3 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0003-987X J9 ARCH DERMATOL JI Arch. Dermatol. PD JUN PY 1991 VL 127 IS 6 BP 908 EP 909 DI 10.1001/archderm.127.6.908 PG 2 WC Dermatology SC Dermatology GA FQ350 UT WOS:A1991FQ35000021 PM 1827973 ER PT J AU LEVINE, L ROSE, MS FRANCESCONI, RP NEUFER, PD SAWKA, MN AF LEVINE, L ROSE, MS FRANCESCONI, RP NEUFER, PD SAWKA, MN TI FLUID REPLACEMENT DURING SUSTAINED ACTIVITY IN THE HEAT - NUTRIENT SOLUTION VS WATER SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article ID EXERCISE; HYPOHYDRATION; TEMPERATURE; BEVERAGES AB This study examined the thermoregulatory and hydrational status of men during sustained activity in a hot-dry (37-degrees-C, 20% rh) environment while they consumed only a nutrient solution (nutrient), or consumed only colored, flavored water (control). Eleven heat acclimated young men attempted 24-h sustained activity experiments. These experiments consisted of alternating 45-min bouts of treadmill walking (410 W, approximately 30% Vo2max) and rest (including sedentary activity). Data were analyzed through 13 h (after 13 h subjects began to discontinue testing). No significant differences between trials were observed for metabolic rate, fluid intake, skin or rectal temperature, sweating rate, plasma volume (as indicated by hemoglobin concentration) or plasma glucose concentrations. By the 8th h plasma osmolality was higher and by the 11th h plasma free fatty acids were lower during the nutrient trial compared to the control. In separate experiments with nine different men, the gastric emptying rates of the nutrient solution and water were compared during exercise (55% Vo2max) in the heat (35-degrees-C, 20% rh). The gastric emptying rates of the nutrient solution and water were similar (approximately 20 ml . min-1). These data indicate that during 13 h of sustained activity in a hot environment, the nutrient solution and water provided similar thermoregulatory and hydrational benefits. RP LEVINE, L (reprint author), USA,ENVIRONM MED RES INST,KANSAS ST,NATICK,MA 01760, USA. NR 25 TC 8 Z9 8 U1 0 U2 1 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD JUN PY 1991 VL 62 IS 6 BP 559 EP 564 PG 6 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA FP096 UT WOS:A1991FP09600010 PM 1859343 ER PT J AU MONTROSE, CJ LITOVITZ, TA ELSON, EC AF MONTROSE, CJ LITOVITZ, TA ELSON, EC TI AUGMENTED TRANSCRIPTION BY ELECTROMAGNETIC-FIELD EXPOSURE - THE EXPERIMENTAL-TECHNIQUE AFFECTS THE MEASURED TRANSIENT-RESPONSE SO BIOELECTROCHEMISTRY AND BIOENERGETICS LA English DT Article AB The exposure of cells to relatively low intensity modulated microwaves or pulsed and low frequency electromagnetic fields results in a transient augmentation of transcriptional activity. One of the experimental methods for monitoring this involves measuring the incorporation of a radioactive tracer such as tritiated uridine into RNA. A previously described linear multi-step chemical reaction model that accounts for many of the principal features observed in such experiments is used to define a hypothetical "benchmark" system in terms of which a variety of protocols used in radioactive precursor uptake methods can be evaluated. C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. RP MONTROSE, CJ (reprint author), CATHOLIC UNIV AMER,VITREOUS STATE LAB,WASHINGTON,DC 20064, USA. NR 13 TC 2 Z9 2 U1 0 U2 0 PU ELSEVIER SCIENCE SA LAUSANNE PI LAUSANNE 1 PA PO BOX 564, 1001 LAUSANNE 1, SWITZERLAND SN 0302-4598 J9 BIOELECTROCH BIOENER JI Bioelectrochem. Bioenerg. PD JUN PY 1991 VL 25 IS 3 BP 383 EP 394 DI 10.1016/0302-4598(91)80004-M PG 12 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA FV927 UT WOS:A1991FV92700004 ER PT J AU HOWARD, SL AF HOWARD, SL TI PREDICTION OF THE ONSET ENERGY OF THE FINE-STRUCTURE TRANSITION IN NEON CHARGE-TRANSFER SO CANADIAN JOURNAL OF PHYSICS LA English DT Article ID CROSSED-BEAM TECHNIQUE AB Data from previous cross-beam experiments have demonstrated a low-energy onset of the endoergic fine-structure transition in the charge-transfer reaction of rare gases. Correlation of the spin-orbit energies within this group of the periodic table with the onset collision energy from these experiments is used to predict the onset energy for Ne. The correlation also shows that a three-dimensional model should be used to theoretically describe the intermediate R2+ instead of a one-dimensional model. RP HOWARD, SL (reprint author), USA,BALLIST RES LABS,ABERDEEN PROVING GROUND,MD 21005, USA. NR 13 TC 0 Z9 0 U1 0 U2 0 PU NATL RESEARCH COUNCIL CANADA PI OTTAWA PA RESEARCH JOURNALS, MONTREAL RD, OTTAWA ON K1A 0R6, CANADA SN 0008-4204 J9 CAN J PHYS JI Can. J. Phys. PD JUN PY 1991 VL 69 IS 6 BP 655 EP 657 PG 3 WC Physics, Multidisciplinary SC Physics GA FZ294 UT WOS:A1991FZ29400001 ER PT J AU MAEL, FA AF MAEL, FA TI CAREER CONSTRAINTS OF OBSERVANT JEWS SO CAREER DEVELOPMENT QUARTERLY LA English DT Article RP MAEL, FA (reprint author), USA,RES INST,ALEXANDRIA,VA, USA. NR 21 TC 3 Z9 3 U1 0 U2 1 PU AMER COUNSELING ASSOC PI ALEXANDRIA PA 5999 STEVENSON AVE, ALEXANDRIA, VA 22304-3300 SN 0889-4019 J9 CAREER DEV Q JI Career Dev. Q. PD JUN PY 1991 VL 39 IS 4 BP 341 EP 349 PG 9 WC Psychology, Applied SC Psychology GA FP960 UT WOS:A1991FP96000009 ER PT J AU DUFFY, P PHILLIPS, YY AF DUFFY, P PHILLIPS, YY TI CAFFEINE CONSUMPTION DECREASES THE RESPONSE TO BRONCHOPROVOCATION CHALLENGE WITH DRY GAS HYPERVENTILATION SO CHEST LA English DT Article ID COLD AIR; INHALED HISTAMINE; BRONCHIAL HYPERRESPONSIVENESS; INDUCED BRONCHOCONSTRICTION; ASTHMATIC SUBJECTS; THEOPHYLLINE; METHACHOLINE; RESPONSIVENESS; REACTIVITY; PHARMACOKINETICS AB Objective: To determine whether caffeine consumption affects bronchoprovocation challenge (BPC). Design: A prospective, double-blind, placebo-controlled, randomized, crossover trial. Patients: Eleven nonsmoking men, aged 18 to 42 years, with normal baseline spirometry and evidence of exercise-induced bronchospasm. Intervention: On three separate test days, each individual received, in random order, either placebo, 5 mg/kg caffeine, or 10 mg/kg caffeine, and then underwent BPC with eucapnic voluntary hyperventilation (EVH). Results: Caffeine (10 mg/kg) significantly reduced bronchoconstriction compared to placebo (p = 0.02). The reduction in bronchoconstriction correlated with the serum level of caffeine (p = 0.014). Conclusions: Caffeine decreases bronchoconstriction due to EVH. Caffeine should be eliminated from diet prior to BPC. C1 WALTER REED ARMY MED CTR,DEPT MED,WASHINGTON,DC 20307. NR 30 TC 24 Z9 25 U1 0 U2 3 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 SN 0012-3692 J9 CHEST JI Chest PD JUN PY 1991 VL 99 IS 6 BP 1374 EP 1377 DI 10.1378/chest.99.6.1374 PG 4 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA FP997 UT WOS:A1991FP99700013 PM 2036818 ER PT J AU SHANLEY, DJ BUCKNER, AB ALEXANDER, HG AF SHANLEY, DJ BUCKNER, AB ALEXANDER, HG TI UNUSUAL PELVIC ACTIVITY FOUND ON BONE-SCAN SO CLINICAL NUCLEAR MEDICINE LA English DT Article AB Normal renal uptake and excretion of radionuclide agents used for bone scintigraphy allow for gross visualization of the genitourinary system. The kidneys and urinary bladder can usually be identified on images from a bone scan, and retroperitoneal or pelvic masses may be suspected if abnormalities in the location or configuration of these organs are present. Further evaluation with other imaging modalities, such as CT or ultrasound, can provide important diagnostic information because of their ability to better define the regional anatomy. C1 TRIPLER ARMY MED CTR,DEPT RADIOL & NUCL MED,HONOLULU,HI 96859. NR 0 TC 4 Z9 4 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0363-9762 J9 CLIN NUCL MED JI Clin. Nucl. Med. PD JUN PY 1991 VL 16 IS 6 BP 453 EP 454 DI 10.1097/00003072-199106000-00019 PG 2 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA FR125 UT WOS:A1991FR12500019 PM 1868664 ER PT J AU JACOB, E SETTERSTROM, JA BACH, DE HEATH, JR MCNIESH, LM CIERNY, G AF JACOB, E SETTERSTROM, JA BACH, DE HEATH, JR MCNIESH, LM CIERNY, G TI EVALUATION OF BIODEGRADABLE AMPICILLIN ANHYDRATE MICROCAPSULES FOR LOCAL TREATMENT OF EXPERIMENTAL STAPHYLOCOCCAL OSTEOMYELITIS SO CLINICAL ORTHOPAEDICS AND RELATED RESEARCH LA English DT Article ID BONE-CEMENT; BEADS; GENTAMICIN; RELEASE AB Successful treatment of chronic osteomyelitis requires sustained high concentrations of antibiotics locally within the infected bone. The efficacy of biodegradable (poly-DL-lactide-co-glycolide) microspheres containing 30.7% ampicillin anhydrate for the local treatment of experimental staphylococcal osteomyelitis was evaluated in rabbits. In the initial experiment, antibiotic therapy was initiated immediately following injection of Staphylococcus aureus into the proximal tibial metaphysis. A single intramedullary injection of microencapsulated ampicillin (100 mg) prevented osteomyelitis in all seven animals tested and was as effective as a two-week course of parenteral ampicillin administration. When antibiotic therapy was delayed for seven days, osteomyelitis developed in four of eight animals treated locally with microencapsulated ampicillin and in six of eight animals that received parenteral ampicillin therapy. When antibiotic therapy was delayed for seven days and was preceded by debridement, all ten animals treated locally with microencapsulated ampicillin had sterile bone cultures. In contrast, seven of ten animals treated locally with unencapsulated ampicillin powder developed osteomyelitis. Biodegradable antibiotic-loaded microspheres may be of clinical benefit for the local treatment of chronic osteomyelitis. C1 UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. EMORY UNIV,SCH MED,ATLANTA,GA 30322. RP JACOB, E (reprint author), USA,INST DENT RES,WALTER REED ARMY MED CTR,WASHINGTON,DC 20307, USA. NR 18 TC 39 Z9 39 U1 0 U2 2 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0009-921X J9 CLIN ORTHOP RELAT R JI Clin. Orthop. Rel. Res. PD JUN PY 1991 IS 267 BP 237 EP 244 PG 8 WC Orthopedics; Surgery SC Orthopedics; Surgery GA FQ673 UT WOS:A1991FQ67300038 PM 2044286 ER PT J AU HOLLINGER, JO MARK, DE GOCO, P QUIGLEY, N DESVERREAUX, RW BACH, DE AF HOLLINGER, JO MARK, DE GOCO, P QUIGLEY, N DESVERREAUX, RW BACH, DE TI A COMPARISON OF 4 PARTICULATE BONE DERIVATIVES SO CLINICAL ORTHOPAEDICS AND RELATED RESEARCH LA English DT Article ID MATRIX; FIBROBLASTS; IMPLANTS AB Samples of four types of particulate bone matrix derivatives were prepared and surgically inserted into standardized critical-sized defects in calvariae of Long-Evans rats. Implantation of demineralized bone matrix (DBM), bone regenerative matrix, and two types of particulate chemosterilized, antigen-extracted, autolyzed, allogeneic (AAA) bone from endochondral (eAAA) and intramembranous (iAAA) sources will result in the regeneration of bone in orthotopic skull defects. The four preparations were tested in orthotopic, 8-mm calvarial wounds to compare the quantity of new bone that formed 28 days postimplantation. Quantitative computer imaging was used to measure roentgenographic gray levels and bone volume of new trabeculae (calcified plus osteoid). All experimental bone matrix derivatives produced more bone volume than the nontreated control wounds. Bone volume regenerated from iAAA was significantly less than eAAA and DBM-regenerated bone. C1 USA,INST DENT RES,WALTER REED ARMY MED CTR,DEPT PATHOL,WASHINGTON,DC 20307. USA,INST DENT RES,WALTER REED ARMY MED CTR,DEPT ORAL & MAXILLOFACIAL SURG,WASHINGTON,DC 20307. RP HOLLINGER, JO (reprint author), USA,INST DENT RES,WALTER REED ARMY MED CTR,DEPT PHYSIOL,WASHINGTON,DC 20307, USA. NR 25 TC 7 Z9 7 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0009-921X J9 CLIN ORTHOP RELAT R JI Clin. Orthop. Rel. Res. PD JUN PY 1991 IS 267 BP 255 EP 263 PG 9 WC Orthopedics; Surgery SC Orthopedics; Surgery GA FQ673 UT WOS:A1991FQ67300041 PM 2044287 ER PT J AU TAYLOR, AJ HULL, RW COYNE, PE WOOSLEY, RL ELIASSON, AH AF TAYLOR, AJ HULL, RW COYNE, PE WOOSLEY, RL ELIASSON, AH TI PENTAMIDINE-INDUCED TORSADES-DE-POINTES - SAFE COMPLETION OF THERAPY WITH INHALED PENTAMIDINE SO CLINICAL PHARMACOLOGY & THERAPEUTICS LA English DT Article ID ISETHIONATE C1 WALTER REED ARMY MED CTR,DEPT MED,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,CARDIOL INFECT DIS & PULM SERV,WASHINGTON,DC 20307. GEORGETOWN UNIV,DEPT PHARMACOL,WASHINGTON,DC 20007. NR 8 TC 12 Z9 12 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0009-9236 J9 CLIN PHARMACOL THER JI Clin. Pharmacol. Ther. PD JUN PY 1991 VL 49 IS 6 BP 698 EP 700 PG 3 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA FU272 UT WOS:A1991FU27200014 PM 2060258 ER PT J AU CARROUGHER, JG BARRILLEAUX, CN AF CARROUGHER, JG BARRILLEAUX, CN TI ESOPHAGEAL BEZOARS - THE SUCRALITH SO CRITICAL CARE MEDICINE LA English DT Article DE BEZOARS; ESOPHAGUS; SUCRALFATE; TUBE FEEDING; ENTERAL NUTRITION; INTUBATION; ENDOSCOPY ID SUCRALFATE BEZOAR C1 BROOKE ARMY MED CTR,DEPT MED,GASTROENTEROL SERV,FT SAM HOUSTON,TX 78234. RP CARROUGHER, JG (reprint author), BROOKE ARMY MED CTR,DEPT GASTROENTEROL,FT SAM HOUSTON,TX 78234, USA. NR 4 TC 21 Z9 21 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0090-3493 J9 CRIT CARE MED JI Crit. Care Med. PD JUN PY 1991 VL 19 IS 6 BP 837 EP 839 PG 3 WC Critical Care Medicine SC General & Internal Medicine GA FQ864 UT WOS:A1991FQ86400019 PM 1905212 ER PT J AU DAUM, PS BOWERS, WD TEJADA, J MOREHOUSE, D HAMLET, MP AF DAUM, PS BOWERS, WD TEJADA, J MOREHOUSE, D HAMLET, MP TI COOLING TO HEAT OF FUSION (HOF), FOLLOWED BY RAPID REWARMING, DOES NOT REDUCE THE INTEGRITY OF MICROVASCULAR CORROSION CASTS SO CRYOBIOLOGY LA English DT Article ID VASCULAR ENDOTHELIUM; ACUTE FROSTBITE; INJURY RP DAUM, PS (reprint author), USA,ENVIRONM MED RES INST,NATICK,MA 01760, USA. NR 17 TC 2 Z9 2 U1 0 U2 1 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0011-2240 J9 CRYOBIOLOGY JI Cryobiology PD JUN PY 1991 VL 28 IS 3 BP 294 EP 301 DI 10.1016/0011-2240(91)90035-M PG 8 WC Biology; Physiology SC Life Sciences & Biomedicine - Other Topics; Physiology GA FM734 UT WOS:A1991FM73400012 PM 1864085 ER PT J AU NACY, CA MELTZER, MS AF NACY, CA MELTZER, MS TI T-CELL-MEDIATED ACTIVATION OF MACROPHAGES SO CURRENT OPINION IN IMMUNOLOGY LA English DT Article ID TUMOR NECROSIS FACTOR; COLONY-STIMULATING FACTOR; MYCOBACTERIUM-AVIUM COMPLEX; L-ARGININE; GRANULOCYTE-MACROPHAGE; MURINE MACROPHAGES; IFN-GAMMA; INTERFERON-GAMMA; HUMAN-MONOCYTES; CYTO-TOXICITY AB Functionally diverse subpopulations of macrophages and lymphocytes, a wide array of stimulatory signals, and an enormous effector repertoire of activated macrophages keeps this field dynamically active. We review new advances in the identification of cytokines that interact to activate macrophages, and in the discovery of effector molecules used by activated macrophages to destroy their targets. RP NACY, CA (reprint author), WALTER REED ARMY MED CTR,CELLULAR IMMUNOL BRANCH,9620 MED CTR DR,SUITE 200,ROCKVILLE,MD 20850, USA. NR 50 TC 60 Z9 61 U1 0 U2 0 PU CURRENT BIOLOGY LTD PI LONDON PA 34-42 CLEVELAND STREET, LONDON, ENGLAND W1P 6LB SN 0952-7915 J9 CURR OPIN IMMUNOL JI Curr. Opin. Immunol. PD JUN PY 1991 VL 3 IS 3 BP 330 EP 335 DI 10.1016/0952-7915(91)90033-W PG 6 WC Immunology SC Immunology GA FV446 UT WOS:A1991FV44600009 PM 1910612 ER PT J AU BROWER, CF AF BROWER, CF TI SOPHISTICATED STRATEGIST - LINCOLN,GEORGE,A. AND THE DEFEAT OF JAPAN, 1944-45 SO DIPLOMATIC HISTORY LA English DT Article RP BROWER, CF (reprint author), US MIL ACAD,DEPT HIST,W POINT,NY 10996, USA. NR 42 TC 7 Z9 7 U1 0 U2 0 PU BLACKWELL SCIENCE INC PI CAMBRIDGE PA 238 MAIN ST, CAMBRIDGE, MA 02142 SN 0145-2096 J9 DIPLOMATIC HIST JI Dipl. Hist. PD SUM PY 1991 VL 15 IS 3 BP 317 EP 337 DI 10.1111/j.1467-7709.1991.tb00134.x PG 21 WC History SC History GA FX880 UT WOS:A1991FX88000001 ER PT J AU BRYANT, HU BERNTON, EW KENNER, JR HOLADAY, JW AF BRYANT, HU BERNTON, EW KENNER, JR HOLADAY, JW TI ROLE OF ADRENAL-CORTICAL ACTIVATION IN THE IMMUNOSUPPRESSIVE EFFECTS OF CHRONIC MORPHINE TREATMENT SO ENDOCRINOLOGY LA English DT Article ID OPIOID-PEPTIDES; CYTO-TOXICITY; MICE; GLUCOCORTICOIDS; SUPPRESSION; INHIBITION; MODULATION; RELEASE; STRESS AB Implantation of a 75-mg morphine pellet in sham-adrenalectomized male C3H/HeN mice resulted in significant elevations of serum corticosterone levels within 6 h. Corticosterone levels remained elevated (3- to 4-fold) for 72 h and had returned to normal by 120 h postimplantation. Within 48 h of pellet implantation, morphine-pelleted mice exhibited marked reductions in spleen (35%) and thymus weight (56%) relative to values in placebo-pelleted controls. In additon, adrenal hypertrophy was observed in the morphine-pelleted shams (50% increase in adrenal weight relative to placebo). The magnitude of splenic and thymic atrophy was reduced by about 50% in adrenalectomized morphine-pelleted mice (17% and 22% reductions, respectively) compared to that in adrenalectomized mice implanted with placebo pellets. Lymphocyte proliferative responses to the T-cell mitogen Concanavalin-A and the B-cell mitogen bacterial lipopolysaccharide were also significantly reduced in the morphine-pelleted sham mice. Morphine-induced suppression of Concanavalin-A- or lipopolysaccharide-stimulated lymphocyte proliferation was absent in adrenalectomized mice. Effects similar to adrenalectomy (e.g. lessening of magnitude of morphine-induced suppression of lymphoid organ weight and lymphocyte proliferation) were found in morphine-pelleted mice given the glucocorticoid receptor antagonist RU-486 at a dose of 10 mg/kg, twice daily. These studies imply that morphine-induced immunosuppression is at least in part mediated by the increase in serum corticosterone levels after implantation of the morphine pellet. C1 WALTER REED ARMY MED CTR,DEPT MED NEUROSCI,DIV NEUROPSYCHIAT,WASHINGTON,DC 20307. MEDICIS CORP,WASHINGTON,DC. RP BRYANT, HU (reprint author), ELI LILLY & CO,DEPT IMMUNOL PULM & LEUKOTRIENE RES,INDIANAPOLIS,IN 46285, USA. NR 36 TC 109 Z9 113 U1 0 U2 0 PU ENDOCRINE SOC PI BETHESDA PA 4350 EAST WEST HIGHWAY SUITE 500, BETHESDA, MD 20814-4110 SN 0013-7227 J9 ENDOCRINOLOGY JI Endocrinology PD JUN PY 1991 VL 128 IS 6 BP 3253 EP 3258 PG 6 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA FN112 UT WOS:A1991FN11200075 PM 2036988 ER PT J AU BRANNON, JM MYERS, TE GUNNISON, D PRICE, CB AF BRANNON, JM MYERS, TE GUNNISON, D PRICE, CB TI NONCONSTANT POLYCHLORINATED BIPHENYL PARTITIONING IN NEW-BEDFORD HARBOR SEDIMENT DURING SEQUENTIAL BATCH LEACHING SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Article ID DISPERSED ORGANIC POLYMERS; HYDROPHOBIC POLLUTANTS; NATURAL SEDIMENTS; INTERACTION-MODEL; FULVIC-ACIDS; SORPTION; WATER; SOLIDS; COEFFICIENTS; CONTAMINANTS AB Leaching of PCB-contaminated sediment from the New Bedford Harbor Superfund Site, New Bedford, MA, was conducted to assess the long-term mobilization of PCB. Sequential batch extraction of the sediment with distilled-deionized water resulted in a progressive increase in concentrations of PCB, dissolved organic carbon, and numbers of microorganisms in the extract. Sequential extraction with saline water produced extractant PCB concentrations that were relatively constant and significantly lower than those obtained with distilled-deionized water. The PCB mobilization pattern in distilled-deionized water extractant demonstrated dependence of PCB partitioning on ionic strength (as measured by conductivity). The dependency on ionic strength was related to release of sediment organic carbon as ionic strength decreased during sequential batch extraction. The data show that organic colloids and microparticulates mobilized by changes in ionic strength significantly facilitate the release of PCBs. RP BRANNON, JM (reprint author), USA,ENGINEER WATERWAYS EXPT STN,3909 HALLS FERRY RD,VICKSBURG,MS 39181, USA. NR 36 TC 26 Z9 28 U1 1 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0013-936X J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD JUN PY 1991 VL 25 IS 6 BP 1082 EP 1087 DI 10.1021/es00018a010 PG 6 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA FN925 UT WOS:A1991FN92500014 ER PT J AU MAGEE, RR BEACH, LR MITCHELL, TR AF MAGEE, RR BEACH, LR MITCHELL, TR TI LEADERSHIP SUCCESSION - TACTICS FOR CHANGE SO GROUP & ORGANIZATION STUDIES LA English DT Article ID ORGANIZATIONAL PERFORMANCE C1 UNIV ARIZONA,MCCLELLAND CHAIR MANAGEMENT & POLICY,TUCSON,AZ 85721. UNIV WASHINGTON,CARLSON CHAIR MANAGEMENT & ORG,SEATTLE,WA 98195. RP MAGEE, RR (reprint author), US MIL ACAD,DEPT BEHAV SCI & LEADERSHIP,W POINT,NY 10996, USA. NR 19 TC 3 Z9 3 U1 1 U2 3 PU SAGE SCIENCE PRESS PI THOUSAND OAKS PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 SN 0364-1082 J9 GROUP ORGAN STUD PD JUN PY 1991 VL 16 IS 2 BP 125 EP 142 DI 10.1177/105960119101600202 PG 18 WC Psychology, Applied; Management SC Psychology; Business & Economics GA FT375 UT WOS:A1991FT37500002 ER PT J AU HUHMAN, KL MOORE, TO FERRIS, CF MOUGEY, EH MEYERHOFF, JL AF HUHMAN, KL MOORE, TO FERRIS, CF MOUGEY, EH MEYERHOFF, JL TI ACUTE AND REPEATED EXPOSURE TO SOCIAL-CONFLICT IN MALE GOLDEN-HAMSTERS - INCREASES IN PLASMA POMC-PEPTIDES AND CORTISOL AND DECREASES IN PLASMA TESTOSTERONE SO HORMONES AND BEHAVIOR LA English DT Article ID MESOCRICETUS-AURATUS WATERHOUSE; STRESS-INDUCED SUPPRESSION; WILD BABOON; AGGRESSIVE BEHAVIOUR; AGONISTIC BEHAVIOR; FIGHTING BEHAVIOR; MALE RHESUS; MICE; GLUCOCORTICOIDS; HORMONES C1 WALTER REED ARMY MED CTR,DEPT MED NEUROSCI,DIV NEUROPSYCHIAT,WASHINGTON,DC 20307. UNIV MASSACHUSETTS,SCH MED,DEPT PHYSIOL,WORCESTER,MA 01605. FU NINDS NIH HHS [NS23557] NR 28 TC 98 Z9 99 U1 1 U2 7 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0018-506X J9 HORM BEHAV JI Horm. Behav. PD JUN PY 1991 VL 25 IS 2 BP 206 EP 216 DI 10.1016/0018-506X(91)90051-I PG 11 WC Behavioral Sciences; Endocrinology & Metabolism SC Behavioral Sciences; Endocrinology & Metabolism GA FP176 UT WOS:A1991FP17600007 PM 1648544 ER PT J AU PRIER, RE MCNEIL, JG BURGE, JR AF PRIER, RE MCNEIL, JG BURGE, JR TI INPATIENT PSYCHIATRIC MORBIDITY OF HIV-INFECTED SOLDIERS SO HOSPITAL AND COMMUNITY PSYCHIATRY LA English DT Article ID CONSULTATIONS AB To determine differences in inpatient psychiatric morbidity, a total of 573 soldiers seropositive for the human immunodeficiency virus (HIV) were matched with 2,266 seronegative soldiers by age, sex, race, marital status, military rank, length of active service, military occupation, and date of HIV test. An HIV-infected individual was seven times more likely to be hospitalized than an uninfected individual. The rate of total hospitalizations was 16 times higher for the HIV-infected soldiers. The median length of hospital stay was six days for the infected soldiers and four days for the control group. The incidence of psychosis, organic mental disorders, and adjustment disorder in the HIV-infected group was significantly higher. C1 WALTER REED ARMY MED CTR,DIV PREVENT MED,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DIV BIOMETR,WASHINGTON,DC 20307. RP PRIER, RE (reprint author), MONCRIEF ARMY COMMUNITY HOSP,DEPT PSYCHIAT,FT JACKSON,SC 29207, USA. NR 10 TC 8 Z9 8 U1 0 U2 0 PU AMER PSYCHIATRIC ASSOCIATION PI WASHINGTON PA 1400 K ST NW, WASHINGTON, DC 20005 SN 0022-1597 J9 HOSP COMMUNITY PSYCH PD JUN PY 1991 VL 42 IS 6 BP 619 EP 623 PG 5 WC Public, Environmental & Occupational Health; Psychiatry SC Public, Environmental & Occupational Health; Psychiatry GA FP201 UT WOS:A1991FP20100014 PM 1864573 ER PT J AU SWEZEY, RW PEREZ, RS ALLEN, JA AF SWEZEY, RW PEREZ, RS ALLEN, JA TI EFFECTS OF INSTRUCTIONAL STRATEGY AND MOTION PRESENTATION CONDITIONS ON THE ACQUISITION AND TRANSFER OF ELECTROMECHANICAL TROUBLESHOOTING SKILL SO HUMAN FACTORS LA English DT Article ID MAINTENANCE AB Three instructional strategy conditions and the presence or absence of visually presented motion during instruction were manipulated, and their effects on the acquisition and transfer of electromechanical troubleshooting performance were investigated. In this study use of visually presented motion during training (as opposed to static display presentation) was not found to enhance either maintenance performance or transfer on troubleshooting tasks. However, results indicated that subjects trained via a procedure-based training strategy performed more accurately, but slower, than did subjects whose training consisted of conceptual information concerning system structure and function for a reference performance task. When a transfer task was used as the criterion measure, results indicated that training that included conceptual information concerning a system's structure and/or function improved performance. Results thus suggested that some level of generic structure and functional knowledge is required for cross-domain transfer on cognitive troubleshooting tasks, and that this information should include both general procedures for troubleshooting and declarative information on the structure and function of the systems of interest. C1 INTERSCI AMER,STERLING,VA. USA,RES INST,ALEXANDRIA,VA. GEORGE MASON UNIV,FAIRFAX,VA 22030. NR 22 TC 18 Z9 18 U1 1 U2 1 PU HUMAN FACTORS SOC PI SANTA MONICA PA BOX 1369, SANTA MONICA, CA 90406 SN 0018-7208 J9 HUM FACTORS JI Hum. Factors PD JUN PY 1991 VL 33 IS 3 BP 309 EP 323 PG 15 WC Behavioral Sciences; Engineering, Industrial; Ergonomics; Psychology, Applied; Psychology SC Behavioral Sciences; Engineering; Psychology GA GC425 UT WOS:A1991GC42500006 ER PT J AU IACONOCONNORS, LC WELKOS, SL IVINS, BE DALRYMPLE, JM AF IACONOCONNORS, LC WELKOS, SL IVINS, BE DALRYMPLE, JM TI PROTECTION AGAINST ANTHRAX WITH RECOMBINANT VIRUS-EXPRESSED PROTECTIVE ANTIGEN IN EXPERIMENTAL-ANIMALS SO INFECTION AND IMMUNITY LA English DT Article ID BACILLUS-ANTHRACIS; VACCINIA VIRUS; INSECT CELLS; GUINEA-PIGS; BACULOVIRUS; VECTOR; TOXIN; ANTIBODIES; CLONING; GENE AB We previously described the cloning and expression of the protective antigen (PA) gene of Bacillus anthracis in both vaccinia virus and a baculovirus. The antigenicity of the PA products was characterized. PA expressed by the recombinant vaccinia viruses elicited a partial protective immune response against a lethal B. anthracis spore challenge in guinea pigs and mice. The WR strain vaccinia virus recombinant (WR-PA) protected 60% of male mice and 50% of guinea pigs. WR-PA elicited high anti-PA antibody titers in mice but not in guinea pigs. Connaught strain vaccinia virus recombinants failed to protect any immunized animals. PA purified from baculovirus recombinant-infected cultures plus adjuvant partially protected male CBA/J mice and completely protected female Hartley guinea pigs from challenge. Both the recombinant and nonrecombinant PA preparations combined with adjuvant elicited high anti-PA antibody titers in Hartley guinea pigs and CBA/J mice. These data demonstrate that the recombinant baculovirus- and vaccinia virus-produced PAs were immunogenic in both guinea pigs and mice, that the baculovirus-PA recombinant was a useful source of immunogenic PA, and that vaccinia virus-PA recombinants may be feasible live anthrax vaccine candidates worthy of consideration for further development as live vaccines. C1 USA,MED RES INST INFECT DIS,DIV BACTERIOL,FREDERICK,MD 21702. RP IACONOCONNORS, LC (reprint author), USA,MED RES INST INFECT DIS,DIV VIROL,FT DETRICK,FREDERICK,MD 21702, USA. NR 34 TC 48 Z9 49 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD JUN PY 1991 VL 59 IS 6 BP 1961 EP 1965 PG 5 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA FN775 UT WOS:A1991FN77500015 PM 1903769 ER PT J AU DRESSENDORFER, RH KEEN, CL WADE, CE CLAYBAUGH, JR TIMMIS, GC AF DRESSENDORFER, RH KEEN, CL WADE, CE CLAYBAUGH, JR TIMMIS, GC TI DEVELOPMENT OF RUNNERS ANEMIA DURING A 20-DAY ROAD RACE - EFFECT OF IRON SUPPLEMENTS SO INTERNATIONAL JOURNAL OF SPORTS MEDICINE LA English DT Article DE ANEMIA; IRON STATUS; HEMOGLOBIN; LONG-DISTANCE RUNNING ID GASTROINTESTINAL BLOOD-LOSS; DISTANCE RUNNERS; MARATHON RUNNERS; SERUM FERRITIN; DEFICIENCY; PERFORMANCE; HEMOGLOBIN; EXERCISE AB Intense training for long-distance running has been associated with reduced hemoglobin (Hb) levels and low iron stores. Whether iron supplementation helps prevent this "runner's anemia" remains controversial. To determine the relationship between iron status and the early stage of reduced Hb levels in male runners, we examined hematologic variables in 15 healthy men (ages 25 to 47 yrs) who ran twice their regular training distance in 20 days during a 500-km road race. Nine of the runners took iron-containing tablets which provided an average of 36 mg/d of iron, while the other six did not take iron supplements. Only one of the 15 subjects had a low Hb concentration (< 14 g/dl) before the race. After 10 days (285 km), low Hb levels (p < 0.001) were found in 12/15; six of these runners took iron supplements. However, following a 2-day rest period and five more days of running, only 5/15 and 7/15, respectively, had low Hb levels. Serum iron, ferritin, total iron binding capacity, and percent transferrin saturation values remained within normal limits and did not change significantly. Reticulocyte counts progressively increased, becoming 8-fold higher than at baseline (p < 0.001), irrespective of the use of iron supplements. "Runner's anemia" developed in 11/15 (73%) of the subjects, independently of their iron status and iron intake. The reductions in Hb were accompanied by parallel decreases in RBC count and hematocrit, and by a significant reticulocytosis. It was concluded that the development of low Hb levels in these runners was acute in origin, partly reversible with rest, not prevented by iron supplementation, and therefore probably due to a functional hemodilution. C1 UNIV CALIF DAVIS,DEPT INTERNAL MED,DAVIS,CA 95616. UNIV CALIF DAVIS,DEPT NUTR,DAVIS,CA 95616. TRIPLER ARMY MED CTR,DEPT CLIN INVEST,HONOLULU,HI 96859. LETTERMAN ARMY INST RES,DIV MIL TRAUMA RES,SAN FRANCISCO,CA 94129. WILLIAM BEAUMONT HOSP,DIV CARDIOVASC DIS,ROYAL OAK,MI 48072. NR 40 TC 10 Z9 10 U1 0 U2 1 PU GEORG THIEME VERLAG PI STUTTGART PA P O BOX 30 11 20, D-70451 STUTTGART, GERMANY SN 0172-4622 J9 INT J SPORTS MED JI Int. J. Sports Med. PD JUN PY 1991 VL 12 IS 3 BP 332 EP 336 DI 10.1055/s-2007-1024692 PG 5 WC Sport Sciences SC Sport Sciences GA FQ578 UT WOS:A1991FQ57800016 PM 1889946 ER PT J AU AMBRUS, JL HANEIWICH, S CHESKY, L MCFARLAND, P PETERS, MG ENGLER, RJ AF AMBRUS, JL HANEIWICH, S CHESKY, L MCFARLAND, P PETERS, MG ENGLER, RJ TI ABNORMAL RESPONSE TO A HUMAN B-CELL GROWTH-FACTOR IN PATIENTS WITH COMMON VARIABLE IMMUNODEFICIENCY (CVI) SO JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY LA English DT Article ID NECROSIS FACTOR-ALPHA; T-T HYBRIDOMA; LYMPHOCYTES-B; INOSITOL 1,4,5-TRISPHOSPHATE; HUMORAL IMMUNODEFICIENCY; VARIED IMMUNODEFICIENCY; INTERLEUKIN-2 RECEPTORS; FACTOR BCGF; DIFFERENTIATION; HYPOGAMMAGLOBULINEMIA AB Patients with common variable immunodeficiency (CVI) generally fail to produce antigen-specific IgG. We have identified a lymphokine called high molecular weight B cell growth factor (HMW BCGF) that expands an IgG-producing subpopulation of B cells. The B cells from 15 of 16 patients with CVI evaluated in this study failed to proliferate to HMW BCGF, although they proliferated normally to another BCGF, low molecular weight BCGF (LMW BCGF). Nevertheless, 11 patients had more than normal numbers of B cells expressing HMW BCGF receptors. The HMW BCGF receptors on the B cells of three patients with CVI studied were the same molecular weight as the normal HMW BCGF receptor. Examination of B cells from four patients with CVI for intracellular signals produced in normal B cells after stimulation with HMW BCGF revealed that B cells from patients with CVI failed to developed significant increases in cyclic adenosine monophosphate or phosphoinositides after HMW BCGF stimulation. However, cytoplasmic phosphoinositides in the B cells from all four patients with CVI were already increased above what is observed in normal B cells before stimulation with HMW BCGF (either freshly isolated or Staphylococcus aureus Cowan I-activated B cell). Thus, the failure of B cells from patients with CVI to respond to HMW BCGF may be related to their abnormal activation in vivo. Since HMW BCGF expands a subpopulation of memory B cells, the inability of CVI B cells to respond to HMW BCGF may contribute to their abnormal secondary responses to antigens. C1 NIAID,BETHESDA,MD 20892. MED UNIV S CAROLINA,CHARLESTON,SC 29425. WASHINGTON UNIV,SCH MED,DEPT INTERNAL MED,DIV GASTROENTEROL,ST LOUIS,MO 63110. WALTER REED ARMY MED CTR,DIV ALLERGY & IMMUNIZAT,WASHINGTON,DC 20307. RP AMBRUS, JL (reprint author), WASHINGTON UNIV,JEWISH HOSP ST LOUIS,SCH MED,DEPT MED,DIV RHEUMATOL,660 S EUCLID,CAMPUS BOX 8045,ST LOUIS,MO 63110, USA. NR 54 TC 4 Z9 4 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0091-6749 J9 J ALLERGY CLIN IMMUN JI J. Allergy Clin. Immunol. PD JUN PY 1991 VL 87 IS 6 BP 1138 EP 1149 DI 10.1016/0091-6749(91)92160-3 PG 12 WC Allergy; Immunology SC Allergy; Immunology GA FR066 UT WOS:A1991FR06600014 PM 1646248 ER PT J AU WHITE, CS AF WHITE, CS TI KINEMATIC HARDENING FOR NONPROPORTIONAL LOADING SO JOURNAL OF APPLIED MECHANICS-TRANSACTIONS OF THE ASME LA English DT Note C1 USA,MAT TECHNOL LAB,WATERTOWN,MA 02172. NR 4 TC 1 Z9 1 U1 0 U2 0 PU ASME-AMER SOC MECHANICAL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 SN 0021-8936 J9 J APPL MECH-T ASME JI J. Appl. Mech.-Trans. ASME PD JUN PY 1991 VL 58 IS 2 BP 580 EP 581 DI 10.1115/1.2897225 PG 2 WC Mechanics SC Mechanics GA HP716 UT WOS:A1991HP71600040 ER PT J AU DRISKELL, JE SALAS, E AF DRISKELL, JE SALAS, E TI GROUP DECISION-MAKING UNDER STRESS SO JOURNAL OF APPLIED PSYCHOLOGY LA English DT Article ID CRISIS; EXPECTATIONS; PERFORMANCE; STRATEGIES; BEHAVIOR; THREAT C1 USA,CTR TRAINING SYST,ORLANDO,FL. RP DRISKELL, JE (reprint author), FLORIDA MAXIMA CORP,2487 ALOMA AVE,WINTER PK,FL 32792, USA. NR 41 TC 76 Z9 79 U1 3 U2 26 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 SN 0021-9010 J9 J APPL PSYCHOL JI J. Appl. Psychol. PD JUN PY 1991 VL 76 IS 3 BP 473 EP 478 DI 10.1037//0021-9010.76.3.473 PG 6 WC Psychology, Applied; Management SC Psychology; Business & Economics GA FQ059 UT WOS:A1991FQ05900015 ER PT J AU RICE, BM TREVINO, SF AF RICE, BM TREVINO, SF TI AN INTERMOLECULAR H-O POTENTIAL FOR METHYL ROTATIONS IN SOLID NITROMETHANE SO JOURNAL OF CHEMICAL PHYSICS LA English DT Article AB A reliable determination of the (H-O) intermolecular potential by which molecules of nitromethane interact with each other is presented. This effort is based upon a very complete body of experimental information which is available on the crystal structure and the rotational properties of the methyl group of the molecule in the solid state. The crystal structure is known in the temperature range of 4-233 K. The rotational properties of the methyl group of the molecule have been studied by inelastic neutron scattering with which the energy levels, including the ground state tunnel splitting, have been measured in both the protonated and deuterated samples. These studies provide a most comprehensive characterization of any such similar molecular crystal. The measured properties are directly related to the intermolecular potential but the inversion of the underlying intermolecular potential from the measured properties has not been straight forward. We describe the application of the principle of maximum entropy in the determination of an intermolecular H-O potential. The resulting potential is of a novel character. At 3.5 GPa x-ray diffraction studies indicate that the equilibrium orientation of the methyl group in crystalline nitromethane is rotated 45-degrees from the position in the low-temperature ambient pressure form. Calculations of the potential energy as a function of methyl group orientation in crystalline nitromethane at a pressure of 3.5 GPa using the intermolecular potential described herein has reproduced this experimental observation. C1 AED,ARDEC,PICATINNY ARSENAL,NJ. NATL INST STAND & TECHNOL,GAITHERSBURG,MD. RP RICE, BM (reprint author), USA,BALLIST RES LABS,SLCBR IB I,ABERDEEN PROVING GROUND,MD 21005, USA. NR 14 TC 16 Z9 16 U1 0 U2 3 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-9606 J9 J CHEM PHYS JI J. Chem. Phys. PD JUN 1 PY 1991 VL 94 IS 11 BP 7478 EP 7485 DI 10.1063/1.460178 PG 8 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA FL837 UT WOS:A1991FL83700055 ER PT J AU KAIN, KC LANAR, DE AF KAIN, KC LANAR, DE TI DETERMINATION OF GENETIC-VARIATION WITHIN PLASMODIUM-FALCIPARUM BY USING ENZYMATICALLY AMPLIFIED DNA FROM FILTER-PAPER DISKS IMPREGNATED WITH WHOLE-BLOOD SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID CIRCUMSPOROZOITE PROTEIN; MEROZOITE INVASION; MALARIA; ANTIBODIES; ANTIGEN; PROBES; ERYTHROCYTES; VIVAX AB A new method which allows the enzymatic amplification of DNA extracted from whole blood dried on filter paper disks is presented. The method was used to study heterogeneity within an erythrocyte-binding antigen (EBA-175) of Plasmodium falciparum. Blood specimens from malaria-infected patients in Southeast Asia and Africa were spotted onto filter paper, dried, and transported for processing. P. falciparum DNA was extracted by boiling the filter paper disks in the presence of Chelex-100 ion-chelating resin, amplified by the polymerase chain reaction, and analyzed for the presence of genetic variation. In all cases examined, plasmodial DNA was successfully amplified and characterized from filter paper disks. Hybridization of the polymerase chain reaction products with internal probes demonstrated simultaneous infection with two strains of P. falciparum in two patients. This technique represents a sensitive and practical field method for the determination of genetic variation within P. falciparum and the study of molecular epidemiology. RP KAIN, KC (reprint author), WALTER REED ARMY MED CTR,DEPT IMMUNOL,WASHINGTON,DC 20307, USA. RI Lanar, David/B-3560-2011 NR 20 TC 116 Z9 119 U1 0 U2 4 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD JUN PY 1991 VL 29 IS 6 BP 1171 EP 1174 PG 4 WC Microbiology SC Microbiology GA FM520 UT WOS:A1991FM52000015 PM 1864936 ER PT J AU CARNAHAN, AM CHAKRABORTY, T FANNING, GR VERMA, D ALI, A JANDA, JM JOSEPH, SW AF CARNAHAN, AM CHAKRABORTY, T FANNING, GR VERMA, D ALI, A JANDA, JM JOSEPH, SW TI AEROMONAS-TROTA SP-NOV, AN AMPICILLIN-SUSCEPTIBLE SPECIES ISOLATED FROM CLINICAL SPECIMENS SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID HYDROPHILA; IDENTIFICATION; SOBRIA AB Previous DNA hybridization studies established 12 Aeromonas genospecies, from which nine phenotypic species have been proposed: Aeromonas hydrophila, A. sorbria, A. caviae, A. media, A. veronii, A. schubertii, A. salmonicida, A. eucrenophila, and A. jandaei. We have delineated a new Aeromonas genospecies, A. trota, on the basis of 13 strains isolated primarily from fecal specimens from southern and southeastern Asia. All strains were highly related to the proposed type strain, AH2 (ATCC 49657T): 51 to 100% (60-degrees-C) and 49 to 99% (75-degrees-C), with 0.2 to 2.2 divergence. AH2 was only 16 to 41% (60-degrees-C) related to all other Aeromonas type strains and DNA group definition strains. The unique profile of A. trota includes negative reactions for esculin hydrolysis, arabinose fermentation, and the Voges-Proskauer test, positive reactions for cellobiose fermentation, lysine decarboxylation, and citrate utilization, and susceptibility to ampicillin, as determined by the broth microdilution MIC method and the Bauer-Kirby disk diffusion method (10-mu-g). Nine of the A. trota strains were from a single study of 165 geographically diverse aeromonads. This finding questions the efficacy of screening fecal specimens for Aeromonas spp. with ampicillin-containing media and suggests a previously unrecognized prevalence of this new species. C1 UNIV MARYLAND,DEPT MICROBIOL,COLLEGE PK,MD 20742. UNIV WURZBURG,INST GENET & MIKROBIOL,W-8700 WURZBURG,GERMANY. CALIF DEPT HLTH SERV,MICROBIAL DIS LAB,BERKELEY,CA 94704. WALTER REED ARMY MED CTR,DIV PATHOL,WASHINGTON,DC 20307. NR 27 TC 102 Z9 107 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD JUN PY 1991 VL 29 IS 6 BP 1206 EP 1210 PG 5 WC Microbiology SC Microbiology GA FM520 UT WOS:A1991FM52000021 PM 1864939 ER PT J AU SHUSTER, JJ CANTOR, AB MCWILLIAMS, N POLE, JG CASTLEBERRY, RP MARCUS, R PICK, T SMITH, EI HAYES, FA AF SHUSTER, JJ CANTOR, AB MCWILLIAMS, N POLE, JG CASTLEBERRY, RP MARCUS, R PICK, T SMITH, EI HAYES, FA TI THE PROGNOSTIC-SIGNIFICANCE OF AUTOLOGOUS BONE-MARROW TRANSPLANT IN ADVANCED NEUROBLASTOMA SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Article ID ADVANCED NEURO-BLASTOMA C1 UNIV FLORIDA, GAINESVILLE, FL 32611 USA. VIRGINIA COMMONWEALTH UNIV, MED COLL VIRGINIA, RICHMOND, VA 23298 USA. UNIV ALABAMA, BIRMINGHAM, AL 35294 USA. BROOKE ARMY MED CTR, FT SAM HOUSTON, TX 78234 USA. OKLAHOMA UNIV HLTH SCI CTR, OKLAHOMA CITY, OK USA. ST JUDE CHILDRENS RES HOSP, MEMPHIS, TN 38101 USA. RP SHUSTER, JJ (reprint author), PEDIAT ONCOL GRP, STAT OFF, SUITE A, 2ND FLOOR, 4949 W PINE BLVD, ST LOUIS, MO 63108 USA. FU NCI NIH HHS [CA-29281, CA-31566, CA-29139] NR 11 TC 51 Z9 51 U1 0 U2 0 PU AMER SOC CLINICAL ONCOLOGY PI ALEXANDRIA PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA SN 0732-183X J9 J CLIN ONCOL JI J. Clin. Oncol. PD JUN PY 1991 VL 9 IS 6 BP 1045 EP 1049 PG 5 WC Oncology SC Oncology GA FP238 UT WOS:A1991FP23800021 PM 2033418 ER PT J AU GEISBERT, TW RHODERICK, JB JAHRLING, PB AF GEISBERT, TW RHODERICK, JB JAHRLING, PB TI RAPID IDENTIFICATION OF EBOLA VIRUS AND RELATED FILOVIRUSES IN FLUID SPECIMENS USING INDIRECT IMMUNOELECTRON MICROSCOPY SO JOURNAL OF CLINICAL PATHOLOGY LA English DT Note AB Recent filoviral outbreaks in animal primates have raised public awareness of the potential for filoviruses to become a public health concern; methods that efficiently identify these viruses are therefore of high priority. An indirect immunoelectron microscopy method, which uses homologous guinea pig polyclonal antiserum, successfully identified Ebola-related (Reston) virus particles in serum and tissue culture fluid specimens with infectivity titres of 300 plaque forming units (pfu) per ml or more. The sensitivity of this procedure is sufficient to show virus in most acute phase sera, and is equal to that of the antigen capture enzyme linked immunosorbent assay (ELISA). The immunoelectron microscopy fluid technique can differentiate among antigenically distinct filoviruses in less than three hours. It should be valuable in the rapid diagnosis of potential filoviral infections. RP GEISBERT, TW (reprint author), USA,MED RES INST INFECT DIS,DIV DIS ASSESSMENT,FT DETRICK,FREDERICK,MD 21702, USA. NR 4 TC 13 Z9 15 U1 1 U2 3 PU BRITISH MED JOURNAL PUBL GROUP PI LONDON PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON, ENGLAND WC1H 9JR SN 0021-9746 J9 J CLIN PATHOL JI J. Clin. Pathol. PD JUN PY 1991 VL 44 IS 6 BP 521 EP 522 DI 10.1136/jcp.44.6.521 PG 2 WC Pathology SC Pathology GA FQ452 UT WOS:A1991FQ45200021 PM 2066435 ER PT J AU SMITH, ER WAGNER, SE AF SMITH, ER WAGNER, SE TI LITTORAL ENVIRONMENT OBSERVATION PROGRAM SO JOURNAL OF COASTAL RESEARCH LA English DT Article DE BREAKING WAVES; COASTAL OBSERVATIONS; CURRENTS; NEARSHORE BERMS; SAND BYPASSING; SEDIMENT TRANSPORT; WIND AB The Littoral Environment Observation Program (LEO) was instituted in 1968 to provide low-cost data on waves, currents, and sand movements along beaches. The data base currently consists of over 350 sites in the United States. Data collected from the program has been beneficial for design and monitoring of numerous projects. LEO data are not as accurate as measured data, but the program can provide data in areas where instrumentation cannot be placed or where funds are not available, and efforts are being made to improve the accuracy of LEO data. Future modifications to the program include transfer of the data base to personal computers, inclusion of beach width and berm height in the observations, and improvements to measurement techniques. RP SMITH, ER (reprint author), USA,CTR COASTAL ENGN RES,WATERWAYS EXPT STN,VICKSBURG,MS 39180, USA. NR 10 TC 0 Z9 0 U1 0 U2 0 PU COASTAL EDUCATION & RESEARCH FOUNDATION PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 SN 0749-0208 J9 J COASTAL RES JI J. Coast. Res. PD SUM PY 1991 VL 7 IS 3 BP 595 EP 605 PG 11 WC Environmental Sciences; Geography, Physical; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Physical Geography; Geology GA FW195 UT WOS:A1991FW19500001 ER PT J AU NEELY, ES NEATHAMMER, R AF NEELY, ES NEATHAMMER, R TI LIFE-CYCLE MAINTENANCE COSTS BY FACILITY USE SO JOURNAL OF CONSTRUCTION ENGINEERING AND MANAGEMENT-ASCE LA English DT Article AB The U.S. Army Construction Engineering Research Laboratory, Champaign, Ill., has developed several data bases for determining life-cycle costs of building facilities by functional use. Four data bases have been implemented in a DOS environment for an embellished personal computer. The simplest data base contains average annual maintenance per square foot by building use. The second data base contains both yearly component replacement and annual reoccurring maintenance cost per square foot by building use. The third data base contains labor hours per square foot, equipment hours per square foot, and material cost per square foot by building age and building use. The most detailed data base contains labor hours per square foot, equipment hours per square foot, and material costs per square foot for each individual maintenance task. All data bases can be applied by any organization (cities, universities, corporations) for resource prediction. The data bases are currently being applied by several Army organizations, the Department of the Interior-Historical Preservation Council, Department of the Navy, ASTM (American Society for Testing Materials), and many private organizations. Contents and application of the data bases are described in this paper. RP NEELY, ES (reprint author), USA,CONSTRUT ENGN RES LAB,POB 4005,CHAMPAIGN,IL 61824, USA. NR 0 TC 6 Z9 6 U1 1 U2 3 PU ASCE-AMER SOC CIVIL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-9364 J9 J CONSTR ENG M ASCE JI J. Constr. Eng. Manage.-ASCE PD JUN PY 1991 VL 117 IS 2 BP 310 EP 320 DI 10.1061/(ASCE)0733-9364(1991)117:2(310) PG 11 WC Construction & Building Technology; Engineering, Industrial; Engineering, Civil SC Construction & Building Technology; Engineering GA FN172 UT WOS:A1991FN17200009 ER PT J AU BUDD, CS WELLER, RN KULILD, JC AF BUDD, CS WELLER, RN KULILD, JC TI A COMPARISON OF THERMOPLASTICIZED INJECTABLE GUTTA-PERCHA OBTURATION TECHNIQUES SO JOURNAL OF ENDODONTICS LA English DT Article ID MORPHOLOGY AB This study compared the quality of obturation of high- and low-temperature thermoplasticized injectable gutta-percha techniques and standard lateral condensation. A new model system was developed to more closely simulate the clinical environment. All obturations were performed in this same model which allowed direct comparisons between the different techniques. The resultant mass of gutta-percha was visually examined and graded for each obturation. Statistical analysis of the results indicated that both thermoplasticized injectable techniques were significantly better than lateral condensation. There was no significant difference between either of the thermoplastic obturation techniques. C1 USA,DENT ACTIV,ENDODONT RESIDENCY PROGRAM,FT GORDON,GA 30905. NR 18 TC 52 Z9 54 U1 0 U2 2 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0099-2399 J9 J ENDODONT JI J. Endod. PD JUN PY 1991 VL 17 IS 6 BP 260 EP 264 DI 10.1016/S0099-2399(06)81863-7 PG 5 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA FP240 UT WOS:A1991FP24000002 PM 1940750 ER PT J AU TRUMAN, KZ PETRUSKA, DJ NORMAN, CD AF TRUMAN, KZ PETRUSKA, DJ NORMAN, CD TI CREEP, SHRINKAGE, AND THERMAL EFFECTS ON MASS CONCRETE STRUCTURE SO JOURNAL OF ENGINEERING MECHANICS-ASCE LA English DT Article AB A nonlinear incremental structural analysis including thermal loads was performed on a lock monolith in order to assess the effects of creep, shrinkage, adiabatic temperature rise, and construction procedures with respect to tensile stresses and strains. Mass concrete structures are vulnerable to cracking as a result of high tensile stresses and strains due to thermal loads, material properties, and mechanical loads. The results of a parametric study considering upper and lower bounds on adiabatic temperature rise, creep, and shrinkage coupled with the incremental construction model are presented. Stress and strain history plots are shown and discussed with respect to typical locations within the monolith. The time history plots are essential in tracking the effects of the construction sequence. The results presented are used to give guidance for future analysis and designs of mass concrete structures. C1 WATERWAYS EXPT STN,VICKSBURG,MS 39180. RP TRUMAN, KZ (reprint author), WASHINGTON UNIV,DEPT CIVIL ENGN,ST LOUIS,MO 63130, USA. NR 10 TC 7 Z9 7 U1 1 U2 2 PU ASCE-AMER SOC CIVIL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-9399 J9 J ENG MECH-ASCE JI J. Eng. Mech.-ASCE PD JUN PY 1991 VL 117 IS 6 BP 1274 EP 1288 DI 10.1061/(ASCE)0733-9399(1991)117:6(1274) PG 15 WC Engineering, Mechanical SC Engineering GA FN169 UT WOS:A1991FN16900005 ER PT J AU BARKO, JW SMART, RM MCFARLAND, DG AF BARKO, JW SMART, RM MCFARLAND, DG TI INTERACTIVE EFFECTS OF ENVIRONMENTAL-CONDITIONS ON THE GROWTH OF SUBMERSED AQUATIC MACROPHYTES SO JOURNAL OF FRESHWATER ECOLOGY LA English DT Article ID INORGANIC CARBON; PLANTS; LIGHT; AVAILABILITY; ZONATION AB Variations in the growth of dioecious Hydrilla verticillata (L.f.) Royle and Vallisneria americana Michx. were examined in a greenhouse under each of two levels (low and high) of light availability, sediment fertility, and inorganic carbon supply. Under low light (ca. 125 uE/m2/s at midday), effects of sediment fertility and inorganic carbon availability on biomass production were relatively minor. Maximum biomass production in both species was achieved under high light (ca. 550 uE/m2/s at midday) on fertile sediment with a ten-fold increase in ambient CO2 supply. However, with other treatment combinations, biomass and morphological responses differed considerably between species. Biomass production in Hydrilla was most responsive to CO2 supply, while in Vallisneria, production was most responsive to sediment fertility. Shoot elongation in response to low light was much more pronounced in Hydrilla than in Vallisneria. Under high light, Hydrilla maximized shoot density (number) with an accompanying increase in biomass production. In Vallisneria, however, shoot (plant) density diminished with increased biomass production under both light levels. In nature, the outcome of competition between these two important submersed macrophyte species may be influenced significantly by interactions among the studied variables. C1 US FISH & WILDLIFE SERV,CTR ENVIRONM MANAGEMENT TECH,ONALASKA,WI 54650. RP BARKO, JW (reprint author), USA,ENGINEER WATERWAYS EXPT STN,ENVIRONM LAB,VICKSBURG,MS 39180, USA. NR 18 TC 27 Z9 31 U1 3 U2 13 PU OIKOS PUBL INC PI LA CROSSE PA PO BOX 2558, LA CROSSE, WI 54601 SN 0270-5060 J9 J FRESHWATER ECOL JI J. Freshw. Ecol. PD JUN PY 1991 VL 6 IS 2 BP 199 EP 207 DI 10.1080/02705060.1991.9665294 PG 9 WC Ecology; Limnology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA GB708 UT WOS:A1991GB70800011 ER PT J AU MAYNORD, ST AF MAYNORD, ST TI FLOW RESISTANCE OF RIPRAP SO JOURNAL OF HYDRAULIC ENGINEERING-ASCE LA English DT Article ID GRAVEL-BED RIVERS AB Flow-resistance coefficients are essential in determining both water-surface elevations and velocities that are used in many aspects of channel design. Channel boundaries requiring scour protection are often armored with riprap revetments that have roughness characteristics that differ from other channel boundaries. Resistance of flow over riprap boundaries is determined from flume data and is compared to the logarithmic and power-law equations. Results show that the power-law equation is applicable to intermediate scale roughness of riprapped surfaces. The logarithmic equation is applicable to small-scale roughness with K(s) on the order of 2D90. The power-law equation can be used for most riprap problems, which covers the range d/D90 from 3 to 30 without significant error. Use of particle size D90 gives slightly better results than use of D50. Strickler's equation is derived from the power-law equation and found to compare favorably with the results of other investigators. Results are applicable to riprap placed with a relatively smooth surface typical of projects constructed in dry conditions. RP MAYNORD, ST (reprint author), USA,HYDR LAB,WATERWAYS EXPT STN,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 23 TC 13 Z9 13 U1 1 U2 5 PU ASCE-AMER SOC CIVIL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-9429 J9 J HYDRAUL ENG-ASCE JI J. Hydraul. Eng.-ASCE PD JUN PY 1991 VL 117 IS 6 BP 687 EP 696 DI 10.1061/(ASCE)0733-9429(1991)117:6(687) PG 10 WC Engineering, Civil; Engineering, Mechanical; Water Resources SC Engineering; Water Resources GA FN171 UT WOS:A1991FN17100001 ER PT J AU INGRAM, JJ ABT, SR RICHARDSON, EV AF INGRAM, JJ ABT, SR RICHARDSON, EV TI SEDIMENT DISCHARGE COMPUTATION USING POINT-SAMPLED SUSPENDED-SEDIMENT DATA SO JOURNAL OF HYDRAULIC ENGINEERING-ASCE LA English DT Article AB A procedure, TSD (total sediment discharge), for computing total sediment discharge using point-sampled suspended-sediment data is presented and tested with field data. TSD was found to provide total sediment discharge estimates that are similar in magnitude to both turbulence flume measurements of total sediment discharge and modified Einstein procedure (MEP) estimates. Assessment of reviewed data sets highlight advantages for selecting the TSD procedure over the MEP. Advantages of the TSD procedure include realistic sediment discharge estimates, greater control in obtaining suspended-sediment samples, automatic sampling, the collection of near-continuous measurements, and time integration for determining the true sediment transport. Also, the use of suspended-sediment point samples enables less time in the field and lower sediment sampling costs. C1 COLORADO STATE UNIV,DEPT CIVIL ENGN,FT COLLINS,CO 80523. RP INGRAM, JJ (reprint author), USA,ENVIRONM LAB,WATERWAYS EXPT STN,VICKSBURG,MS 39180, USA. NR 21 TC 5 Z9 5 U1 1 U2 1 PU ASCE-AMER SOC CIVIL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-9429 J9 J HYDRAUL ENG-ASCE JI J. Hydraul. Eng.-ASCE PD JUN PY 1991 VL 117 IS 6 BP 758 EP 773 DI 10.1061/(ASCE)0733-9429(1991)117:6(758) PG 16 WC Engineering, Civil; Engineering, Mechanical; Water Resources SC Engineering; Water Resources GA FN171 UT WOS:A1991FN17100006 ER PT J AU MELLOUK, S GREEN, SJ NACY, CA HOFFMAN, SL AF MELLOUK, S GREEN, SJ NACY, CA HOFFMAN, SL TI IFN-GAMMA INHIBITS DEVELOPMENT OF PLASMODIUM-BERGHEI EXOERYTHROCYTIC STAGES IN HEPATOCYTES BY AN L-ARGININE-DEPENDENT EFFECTOR MECHANISM SO JOURNAL OF IMMUNOLOGY LA English DT Article ID MACROPHAGE CYTO-TOXICITY; TUMOR NECROSIS FACTOR; T-CELLS RECOGNIZE; ACTIVATED MACROPHAGES; NITROGEN-OXIDES; CIRCUMSPOROZOITE PROTEIN; MALARIA SPOROZOITES; MURINE MACROPHAGES; INTERFERON-GAMMA; KUPFFER CELLS AB Primary cultures of BALB/cJ hepatocytes treated with 10(3) U/ml rIFN-gamma consistently inhibited intracellular Plasmodium berghei liver schizont development by 50 to 70%. Monomethyl-L-arginine (N(G)MMLA), the competitive inhibitor of L-arginine as substrate for production of nitric oxides by hepatocytes, reversed the activity of IFN-gamma on these malaria-infected cells. Reversal of IFN-gamma activity by N(G)MMLA was dose dependent and was maximal at 0.5 mM N(G)MMLA. Depletion of L-arginine by addition of arginase to the culture medium blocked the capacity of IFN-gamma to inhibit parasite development in hepatocytes; addition of excess L-arginine to cultures treated with IFN-gamma in the presence of N(G)MMLA competitively restored IFN-gamma capacity to activate hepatocyte anti-parasite activity. TNF-alpha was neither required for IFN-gamma activity, nor effective at any concentration tested as an inhibitor of schizont development by itself in primary hepatocytes. These data strongly suggest that the action of IFN-gamma on P. berghei-infected hepatocytes is to induce the production of L-arginine-derived nitrogen oxides that are toxic for the intracellular parasite. C1 USN,MED RES INST,MALARIA PROGRAM,BETHESDA,MD 20852. UNIV MARYLAND,SCH MED,CTR VACCINE DEV,DEPT MED,DIV GEOG MED,BALTIMORE,MD 21201. WALTER REED ARMY MED CTR,DEPT CELLULAR IMMUNOL,WASHINGTON,DC 20307. NR 39 TC 160 Z9 161 U1 0 U2 1 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD JUN 1 PY 1991 VL 146 IS 11 BP 3971 EP 3976 PG 6 WC Immunology SC Immunology GA FN054 UT WOS:A1991FN05400041 PM 1903415 ER PT J AU BRYAN, JP SJOGREN, MH MACARTHY, P COX, B KAO, TC PERINE, PL AF BRYAN, JP SJOGREN, MH MACARTHY, P COX, B KAO, TC PERINE, PL TI DOSING SCHEDULE FOR RECOMBINANT HEPATITIS-B VACCINE SO JOURNAL OF INFECTIOUS DISEASES LA English DT Letter ID LONG C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. RP BRYAN, JP (reprint author), UNIFORMED SERV UNIV HLTH SCI,4301 JONES BRIDGE RD,BETHESDA,MD 20814, USA. NR 9 TC 3 Z9 4 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD JUN PY 1991 VL 163 IS 6 BP 1384 EP 1385 PG 2 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA FP534 UT WOS:A1991FP53400038 PM 1828076 ER PT J AU ROSENBERG, YJ WHITE, BD PAPERMASTER, SF ZACK, P JARLING, PB EDDY, GA BURKE, DS LEWIS, MG AF ROSENBERG, YJ WHITE, BD PAPERMASTER, SF ZACK, P JARLING, PB EDDY, GA BURKE, DS LEWIS, MG TI VARIATION IN LYMPHOCYTE-T ACTIVATION AND SUSCEPTIBILITY TO SIVPBJ-14-INDUCED ACUTE DEATH IN MACAQUES SO JOURNAL OF MEDICAL PRIMATOLOGY LA English DT Article; Proceedings Paper CT MEETING ON NONHUMAN PRIMATE MODELS FOR AIDS CY 1990 CL DELTA PRIMATE RES CTR, COVINGTON, LA HO DELTA PRIMATE RES CTR DE CD45RA; T-CELL SUBSETS; MACAQUE ID SIMIAN IMMUNODEFICIENCY VIRUS; RHESUS-MONKEYS; AIDS; CELLS; CHIMPANZEES; RETROVIRUS; INFECTION; MANGABEYS; INDUCTION; SUBSET AB In contrast to pig-tailed and cynomolgus macaques, which die in 6-10 days following infection with the SIV-PBj-14 isolate. only about 50% of rhesus succumbed to rapid disease. Using a CD45RA MAb that delineates memory (CD45RAlo), naive (CD45RAmed) and "activated" (CD45RAhi) T-cell subsets, it was seen that PBMC from pig-tailed and cynomolgus monkeys. unlike rhesus, have reduced CD4iCD8 ratios and a skewing of T cells towards CD45RAhi expression. Such preactivation of CD4+ cells could lead to enhanced viral replication and early death. C1 SO RES INST,BIRMINGHAM,AL 35255. USA,MED RES INST INFECT DIS,FREDERICK,MD 21701. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. RP ROSENBERG, YJ (reprint author), HENRY M JACKSON FDN,RES LAB,1500 E GUIDE DR,ROCKVILLE,MD 20850, USA. NR 17 TC 20 Z9 20 U1 0 U2 0 PU MUNKSGAARD INT PUBL LTD PI COPENHAGEN PA 35 NORRE SOGADE, PO BOX 2148, DK-1016 COPENHAGEN, DENMARK SN 0047-2565 J9 J MED PRIMATOL JI J. Med. Primatol. PD JUN PY 1991 VL 20 IS 4 BP 206 EP 210 PG 5 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA GK919 UT WOS:A1991GK91900013 PM 1682498 ER PT J AU ALBIZO, JM WARD, JR AF ALBIZO, JM WARD, JR TI SOMAN HYDROLYSIS CATALYZED BY HEPES BUFFER SO JOURNAL OF MOLECULAR CATALYSIS LA English DT Article AB The tertiary amine, N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid (HEPES) is a common buffer used in measuring the hydrolysis of neurotoxins such as the phosphonofluoridates soman and sarin. The hydrolysis of soman was monitored in the presence of various concentrations of HEPES at 25-degrees-C and pH = 7. The rate of hydrolysis of soman was linearly related to the concentration of HEPES present as free base in solution. The second-order rate for the HEPES catalysis was 1.6 X 10(-3) M-1 s-1, in contrast to a value of 10 M-1 s-1 for the hydroxide ion-catalyzed nucleophilic attack on soman. RP ALBIZO, JM (reprint author), USA,CTR CHEM RES DEV & ENGN,RES DIRECTORATE,ABERDEEN PROVING GROUND,MD 21010, USA. NR 10 TC 0 Z9 0 U1 1 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-5102 J9 J MOL CATAL PD JUN PY 1991 VL 66 IS 2 BP 191 EP 194 DI 10.1016/0304-5102(91)80012-R PG 4 WC Chemistry, Physical SC Chemistry GA FR615 UT WOS:A1991FR61500012 ER PT J AU SCHAUDIES, RP SATCHITHANANDAM, S CALVERT, RJ AF SCHAUDIES, RP SATCHITHANANDAM, S CALVERT, RJ TI ALTERATION IN LEVELS OF IMMUNOREACTIVE EPIDERMAL GROWTH-FACTOR IN THE GASTROINTESTINAL MUCOSA OF FISCHER RATS FED A DIET CONTAINING 10-PERCENT WHEAT BRAN SO JOURNAL OF NUTRITION LA English DT Article DE EPIDERMAL GROWTH FACTOR; DIETARY FIBER; COLON; RATS ID INDUCED INTESTINAL CARCINOGENESIS; INDUCED COLON CARCINOGENESIS; DEHYDRATED CITRUS FIBER; CELL-PROLIFERATION; FACTOR RECEPTORS; F344 RATS; DIMETHYLHYDRAZINE; CANCER; TUMORS; EGF AB This study evaluates the effect of dietary wheat bran on the levels of immunoreactive epidermal growth factor (EGF) in the gastrointestinal mucosa of Fischer 344 rats. Male rats were fed either a fiber-free diet or a diet containing 10% wheat bran (nine animals per group) for a period of 5 wk. The gastrointestinal tract of each animal was divided into four segments: proximal, middle and distal small intestine, and colon. Mucosa was removed by scraping, EGF was extracted by homogenization and the extracts were analyzed for immunoreactive rat EGF using a homologous RIA. Levels of immunoreactive EGF in all regions of the small intestine of Fischer rats were comparable to our previous measurements in Sprague-Dawley rats, and these levels were unaffected by diet. In contrast, the EGF levels in the colon of the Fischer rats were approximately fivefold greater than those of the Sprague-Dawley rats. These higher levels of immunoreactive EGF in the colon decreased 63% with the addition of 10% wheat bran to the diet (P < 0.02). These results represent the first demonstration of dietary fiber modulating the content of EGF in the gastrointestinal tract. C1 US FDA,DIV NUTR,WASHINGTON,DC 20204. RP SCHAUDIES, RP (reprint author), WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307, USA. NR 44 TC 6 Z9 6 U1 0 U2 0 PU AMER INST NUTRITION PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0022-3166 J9 J NUTR JI J. Nutr. PD JUN PY 1991 VL 121 IS 6 BP 800 EP 805 PG 6 WC Nutrition & Dietetics SC Nutrition & Dietetics GA FM509 UT WOS:A1991FM50900005 PM 2033465 ER PT J AU LAKHANI, H AF LAKHANI, H TI RETENTION COST-BENEFIT-ANALYSIS OF UNITED-STATES-ARMY JUNIOR OFFICERS - A MULTIDISCIPLINARY ANALYSIS SO JOURNAL OF POLITICAL & MILITARY SOCIOLOGY LA English DT Article ID JOB SATISFACTION; MILITARY; REENLISTMENT; TURNOVER; LIFE AB The objective of this research is to integrate and extend the existing analyses on satisfaction with military life and Army retention by estimating a system of simultaneous equations and performing a social cost-benefit analysis. Data from the Department of Defense's (1986) Survey of Officers (n = 1,452) are used to explain the interdependence of retention intentions and satisfaction with Army life of officers for four alternative sources of commissioning. The regression results reveal that retention can be improved by increasing satisfaction with military life, pay, and perceived chances of promotion. The satisfaction with military life is, however, related differently to different types of Army benefit variables for the four groups of officers so that a cafeteria type of benefit program is suggested. The parameter estimates for Army pay are used to estimate the annual incremental cost of retention, which, in turn, is related to the annual incremental social benefit of retaining an additional U.S. Military Academy (USMA) officer versus a Reserve Officers Training Corps (ROTC) officer. The results show that Army compensation policies to increase retention are cost-effective for both groups of officers, however, it is more cost-effective for the Army to retain the USMA officer. RP LAKHANI, H (reprint author), USA,INST RES,MANPOWER & PERSONNEL RES LAB,WASHINGTON,DC 20310, USA. NR 40 TC 8 Z9 8 U1 2 U2 5 PU JOURNAL POLITICAL MILITARY SOCIOLOGY PI DE KALB PA DEPT SOCIOLOGY, NORTHERN ILLINOIS UNIV, DE KALB, IL 60115-2854 SN 0047-2697 J9 J POLIT MIL SOCIOL JI J. Polit. Mil. Soc. PD SUM PY 1991 VL 19 IS 1 BP 1 EP 27 PG 27 WC Political Science; Sociology SC Government & Law; Sociology GA GV732 UT WOS:A1991GV73200001 ER PT J AU IVANHOE, JR ADRIAN, ED KRANTZ, WA AF IVANHOE, JR ADRIAN, ED KRANTZ, WA TI COUNTERACTING THE DARKENING EFFECT OF A METAL FRAMEWORK ON ACRYLIC RESIN DENTURE BASE MATERIAL SO JOURNAL OF PROSTHETIC DENTISTRY LA English DT Article C1 EMORY UNIV,SCH POSTGRAD DENT,ATLANTA,GA 30322. USA,DENTAC,PROSTHODONT RESIDENCY PROGRAM,FT GORDON,GA 30905. USA,REMOVABLE PROSTHODONT SERV,FT GORDON,GA 30905. NR 0 TC 1 Z9 1 U1 1 U2 1 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0022-3913 J9 J PROSTHET DENT JI J. Prosthet. Dent. PD JUN PY 1991 VL 65 IS 6 BP 859 EP 859 DI 10.1016/S0022-3913(05)80030-7 PG 1 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA FT823 UT WOS:A1991FT82300029 PM 2072337 ER PT J AU MCCARTNEY, JW AF MCCARTNEY, JW TI OSSEOINTEGRATED IMPLANT LOCATION SYMBOL SO JOURNAL OF PROSTHETIC DENTISTRY LA English DT Article C1 TRIPLER ARMY MED CTR,PROSTHODONT & MAXILLOFACIAL PROSTHET,HONOLULU,HI 96859. NR 2 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0022-3913 J9 J PROSTHET DENT JI J. Prosthet. Dent. PD JUN PY 1991 VL 65 IS 6 BP 860 EP 861 DI 10.1016/S0022-3913(05)80031-9 PG 2 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA FT823 UT WOS:A1991FT82300030 PM 2072338 ER PT J AU RUBAL, BJ MOODY, JM AF RUBAL, BJ MOODY, JM TI EFFECTS OF RESPIRATION ON SIZE AND FUNCTION OF THE ATHLETIC HEART SO JOURNAL OF SPORTS MEDICINE AND PHYSICAL FITNESS LA English DT Article DE RESPIRATION; HEART SIZE; ECHOCARDIOGRAPHY; STROKE VOLUME; SPONTANEOUS BREATHING; VENTRICULAR INTERDEPENDENCE AB This study compares the effects of quiet breathing on the heart structure and function of pentathlon athletes (n = 11) and a less-conditioned control group (n = 12). Two-dimensional echocardiography was employed to direct an M-mode beam through the heart to minimize measurement errors due to respiratory motion of the heart. Respiration was simultaneously recorded with M-mode echocardiograms from a minimum of five respiratory and an average of 25 cardiac cycles. Athletes had greater (p < 0.01) end-diastolic transverse dimensions (10%), and interventricular septal and left ventricular posterior wall thicknesses (25%). During inspiration right ventricular internal end-diastolic dimensions increased (8 vs 12%) and left ventricular end-diastolic dimension (LVIDd) decreased (7 vs 8%) in athletes and controls, respectively. Although significant reciprocal changes in LVIDd (p < 0.01) occurred during respiration, no respiratory change was noted in the transverse diameter of the heart, interventricular septal, posterior wall thickness, LV end-systolic volume or ejection fraction. Inspiration caused a 21% fall (p < 0.01) in LV stroke volume in both groups. Eighty-four to 92% of the inspiratory decrease in LV stroke volume in the subjects studied could be attributed to ventricular interdependence; no significant interaction was found between level of conditioning and respiration. RP RUBAL, BJ (reprint author), BROOKE ARMY MED CTR,DEPT MED,CARDIOL SERV,FT SAM HOUSTON,TX 78234, USA. NR 0 TC 2 Z9 2 U1 0 U2 0 PU EDIZIONI MINERVA MEDICA PI TURIN PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY SN 0022-4707 J9 J SPORT MED PHYS FIT JI J. Sports Med. Phys. Fit. PD JUN PY 1991 VL 31 IS 2 BP 257 EP 264 PG 8 WC Sport Sciences SC Sport Sciences GA GH444 UT WOS:A1991GH44400022 PM 1753734 ER PT J AU TRUMAN, KZ PETRUSKA, D FERHI, A FEHL, B AF TRUMAN, KZ PETRUSKA, D FERHI, A FEHL, B TI NONLINEAR, INCREMENTAL-ANALYSIS OF MASS-CONCRETE LOCK MONOLITH SO JOURNAL OF STRUCTURAL ENGINEERING-ASCE LA English DT Article AB Using the finite element code, ABAQUS, along with user-developed subroutines and experimentally derived material constants, an incremental construction analysis including thermal loads is performed on a pile-founded massconcrete lock and dam structure. The modeling, analysis technique, and algorithm involved in performing such an analysis is presented. The computer model is based upon a two-dimensional, nonlinear incremental analysis that includes the effects of creep, shrinkage, and aging Young's modulus. The presented algorithm is intended to provide a means of assessing a mass-concrete structures vulnerability to thermal stresses and possible cracking during the construction process. A discussion of the key assumptions and studies that were used in the development of the algorithm are presented. Results from the analyses of a typical lock monolith from the Melvin Price Locks and Dam on the Mississippi River at Alton, Ill. will also be presented to illustrate the usefulness of the algorithm. C1 USA CORPS ENGINEERS,ST LOUIS,MO 63103. RP TRUMAN, KZ (reprint author), WASHINGTON UNIV,DEPT CIVIL ENGN,ST LOUIS,MO 63130, USA. NR 6 TC 6 Z9 6 U1 2 U2 2 PU ASCE-AMER SOC CIVIL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-9445 J9 J STRUCT ENG-ASCE JI J. Struct. Eng.-ASCE PD JUN PY 1991 VL 117 IS 6 BP 1834 EP 1851 DI 10.1061/(ASCE)0733-9445(1991)117:6(1834) PG 18 WC Construction & Building Technology; Engineering, Civil SC Construction & Building Technology; Engineering GA FN174 UT WOS:A1991FN17400016 ER PT J AU SUKUMAR, K PERICH, MJ BOOBAR, LR AF SUKUMAR, K PERICH, MJ BOOBAR, LR TI BOTANICAL DERIVATIVES IN MOSQUITO-CONTROL - A REVIEW SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Review ID BIOLOGICALLY-ACTIVE CONSTITUENTS; NORTH-AMERICAN PLANTS; SEED KERNEL EXTRACTS; AEDES-AEGYPTI; VOLATILE OIL; LARVICIDAL ACTIVITY; HEMIZONIA-FITCHII; ALPHA-TERTHIENYL; LARVAE; CULICIDAE AB A review on the reported uses of chemicals derived from botanical sources is presented, along with the part of the plant used for extraction, the mosquito species studied and the bioactivity observed for 344 plant species. Examples of phytochemicals evaluated against mosquitoes as general toxicants, growth and reproduction inhibitors, repellents and ovipositional deterrents are given. The effects of mosquito species and life stage specificity, solvents used for extraction, phototoxic activity and the geographical source from where the plant compounds are derived are discussed. C1 USA,BIOMED RES & DEV LAB,FREDERICK,MD 21702. NR 129 TC 320 Z9 360 U1 1 U2 24 PU AMER MOSQUITO CONTROL ASSN INC PI LAKE CHARLES PA 707-A EAST PRIEN LAKE ROAD, PO BOX 5416, LAKE CHARLES, LA 70606-5416 SN 8756-971X J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD JUN PY 1991 VL 7 IS 2 BP 210 EP 237 PG 28 WC Entomology SC Entomology GA FX049 UT WOS:A1991FX04900009 PM 1680152 ER PT J AU KLEIN, TA LIMA, JB TANG, AT AF KLEIN, TA LIMA, JB TANG, AT TI HYBRIDIZATION EVIDENCE SUPPORTING SEPARATE SPECIES STATUS FOR ANOPHELES-ALBITARSUS AND ANOPHELES-DEANEORUM (DIPTERA, CULICIDAE) IN BRAZIL SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Note C1 USA,RES UNIT BRASILIA,AMER EMBASSY BRASILIA,MIAMI,FL 34030. UNIV BRASILIA,BR-70910 BRASILIA,DF,BRAZIL. NR 8 TC 7 Z9 7 U1 0 U2 0 PU AMER MOSQUITO CONTROL ASSN INC PI LAKE CHARLES PA 707-A EAST PRIEN LAKE ROAD, PO BOX 5416, LAKE CHARLES, LA 70606-5416 SN 8756-971X J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD JUN PY 1991 VL 7 IS 2 BP 301 EP 303 PG 3 WC Entomology SC Entomology GA FX049 UT WOS:A1991FX04900020 PM 1895089 ER PT J AU ROBERT, LL SCHNEIDER, I WIRTZ, RA AF ROBERT, LL SCHNEIDER, I WIRTZ, RA TI DEET AND PERMETHRIN AS PROTECTANTS AGAINST MALARIA-INFECTED AND UNINFECTED ANOPHELES-STEPHENSI MOSQUITOS SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Note ID PLASMODIUM-FALCIPARUM; SPOROZOITE; DIPTERA AB Deet and permethrin were evaluated as protectants against Plasmodium falciparum-infected, P. berghei-infected and uninfected Anopheles stephensi mosquitoes. Deet 50% effective dose (ED50) values were 3.2-mu-g/cm2 for P. falciparum-infected and 1.9-mu-g/cm2 for uninfected mosquitoes; permethrin values were 0.5-mu-g/cm2 and 0.6-mu-g/cm2, respectively. Deet ED50 values were 2.3-mu-g/cm2 for P. berghei-infected and 1.3-mu-g/cm2 for uninfected mosquitoes; the permethrin values were both 0.5-mu-g/cm2. There were no significant differences in the protective efficacy of deet or permethrin between malaria-infected and uninfected An. stephensi mosquitoes. RP ROBERT, LL (reprint author), WALTER REED ARMY MED CTR,DEPT ENTOMOL,WASHINGTON,DC 20307, USA. NR 17 TC 11 Z9 12 U1 0 U2 1 PU AMER MOSQUITO CONTROL ASSN INC PI LAKE CHARLES PA 707-A EAST PRIEN LAKE ROAD, PO BOX 5416, LAKE CHARLES, LA 70606-5416 SN 8756-971X J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD JUN PY 1991 VL 7 IS 2 BP 304 EP 306 PG 3 WC Entomology SC Entomology GA FX049 UT WOS:A1991FX04900021 PM 1895090 ER PT J AU SCHWARTZ, BF NELSON, RL AF SCHWARTZ, BF NELSON, RL TI DIAGNOSIS OF FETAL ANTERIOR ABDOMINAL-WALL DEFECTS BY USE OF ULTRASONOGRAPHY SO JOURNAL OF THE AMERICAN OSTEOPATHIC ASSOCIATION LA English DT Article DE OMPHALOCELE; GASTROSCHISIS; ANTERIOR ABDOMINAL WALL DEFECT; ULTRASONOGRAPHY; PENTALOGY-OF-CANTRELL; BECKWITH-WIEDEMANN SYNDROME AB Omphalocele and gastroschisis involve protrusion of intestine through a defect in the abdominal wall. It is important to differentiate between the two because of a difference in the incidence of associated anomalies and of chromosomal abnormalities. The distinguishing characteristics are the location of umbilical cord insertion, the echogenicity of the contents of the protruding mass and, usually, the presence or absence of a sac surrounding the mass. Early detection is critical so that decisions can be made about the possibility of surgical correction and the outcome of the pregnancy. We describe an omphalocele detected by ultrasonography in the 20th week of gestation during a routine prenatal check-up. RP SCHWARTZ, BF (reprint author), USA,2D INFANTRY DIV APO,SAN FRANCISCO,CA 96224, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER OSTEOPATHIC ASSN PI CHICAGO PA 142 EAST ONTARIO STREET, CHICAGO, IL 60611-2864 SN 0003-0287 J9 J AM OSTEOPATH ASSOC PD JUN PY 1991 VL 91 IS 6 BP 583 EP & PG 0 WC Medicine, General & Internal SC General & Internal Medicine GA FT821 UT WOS:A1991FT82100005 PM 1831447 ER PT J AU WALKER, CW AF WALKER, CW TI PERFORMANCE OF POLY-3-METHYLTHIOPHENE CATHODES IN LI/SO2 RECHARGEABLE CELLS SO JOURNAL OF THE ELECTROCHEMICAL SOCIETY LA English DT Article ID GLASSY-CARBON ELECTRODES; POLYTHIOPHENE FILMS; POLY(3-METHYLTHIOPHENE); MORPHOLOGY; CONDUCTIVITY AB Electrochemically formed, conducting poly 3-methylthiophene was used as a rechargeable cathode material in lithium/sulfur dioxide cells. Good capacity and very high volumetric energy density were obtained with thin (0.41-1.4-mu-m thick) cathodes in Li(SO2)3AlCl4 electrolyte. Recharge was achieved at potentials below 3.9 V, which should preclude the corrosive effects of formed chlorine. RP WALKER, CW (reprint author), USA,ELECTR TECHNOL & DEVICES LAB,LABCOM,DIV POWER SOURCES,FT MONMOUTH,NJ 07703, USA. NR 19 TC 5 Z9 5 U1 0 U2 1 PU ELECTROCHEMICAL SOC INC PI PENNINGTON PA 10 SOUTH MAIN STREET, PENNINGTON, NJ 08534 SN 0013-4651 J9 J ELECTROCHEM SOC JI J. Electrochem. Soc. PD JUN PY 1991 VL 138 IS 6 BP 1559 EP 1563 DI 10.1149/1.2085832 PG 5 WC Electrochemistry; Materials Science, Coatings & Films SC Electrochemistry; Materials Science GA FQ104 UT WOS:A1991FQ10400008 ER PT J AU MCLEOD, DG WEISS, RB STABLEIN, DM MUGGIA, FM PAULSON, DF ELLIS, JH SPAULDING, JT DONOHUE, JP AF MCLEOD, DG WEISS, RB STABLEIN, DM MUGGIA, FM PAULSON, DF ELLIS, JH SPAULDING, JT DONOHUE, JP TI STAGING RELATIONSHIPS AND OUTCOME IN EARLY STAGE TESTICULAR CANCER - A REPORT FROM THE TESTICULAR CANCER INTERGROUP STUDY SO JOURNAL OF UROLOGY LA English DT Article DE TESTIS; TESTICULAR NEOPLASMS; NEOPLASM STAGING ID ADJUVANT CHEMOTHERAPY; NODE DISSECTION; TESTIS CANCER; ORCHIECTOMY; CARCINOMA; SURVEILLANCE; RELAPSE; TUMORS AB The Testicular Cancer Intergroup Study entered surgically staged patients with nonseminomatous tumor and metastases limited to the regional lymph nodes into a previously reported cooperative trial of immediate versus delayed therapy for positive retroperitoneal node disease. Patients with negative nodes (stage I) were placed in an observation registry with specified treatment strategy upon relapse. Of 264 stage I cancer patients 27 (10.2%) had recurrence: 5 of these 27 patients died after recurrence of the testicular malignancies, while 4 other nontumor-related deaths have occurred. Pre-lymphadenectomy staging characteristics observed to predict significantly node positivity are the results of radiological examinations, presence of tumor invasion, vascular invasion and tumor histology. In a multiple logistic regression analysis with these variables, misclassification still occurs in more than a fourth of the patients. Future refinements in diagnosis may allow for better prediction of these patients at risk to have positive lymph nodes and ultimately recurrence. Presently, if assessment of nodal involvement is the objective, noninvasive procedures are not an adequate substitute for surgical staging with modified lymphadenectomy. C1 UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. EMMES CORP,POTOMAC,MD. UNIV SO CALIF,LOS ANGELES,CA 90089. UNIV CALIF SAN FRANCISCO,SAN FRANCISCO,CA 94143. DUKE UNIV,MED CTR,DURHAM,NC 27710. INDIANA UNIV,INDIANAPOLIS,IN 46204. RP MCLEOD, DG (reprint author), WALTER REED ARMY MED CTR,UROL SERV,WASHINGTON,DC 20307, USA. NR 21 TC 84 Z9 84 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-5347 J9 J UROLOGY JI J. Urol. PD JUN PY 1991 VL 145 IS 6 BP 1178 EP 1183 PG 6 WC Urology & Nephrology SC Urology & Nephrology GA FN923 UT WOS:A1991FN92300013 PM 1851890 ER PT J AU HANSBERRY, KL THOMPSON, IM BAUMAN, J DEPPE, S RODRIGUEZ, FR AF HANSBERRY, KL THOMPSON, IM BAUMAN, J DEPPE, S RODRIGUEZ, FR TI A PROSPECTIVE COMPARISON OF THROMBOEMBOLIC STOCKINGS, EXTERNAL SEQUENTIAL PNEUMATIC COMPRESSION STOCKINGS AND HEPARIN SODIUM DIHYDROERGOTAMINE MESYLATE FOR THE PREVENTION OF THROMBOEMBOLIC COMPLICATIONS IN UROLOGICAL SURGERY SO JOURNAL OF UROLOGY LA English DT Article DE THROMBOSIS; THROMBOEMBOLISM; THROMBOPHLEBITIS; DIHYDROERGOTAMINE; CLOTHING ID DEEP-VEIN THROMBOSIS; VENOUS THROMBOSIS; PULMONARY-EMBOLISM; RANDOMIZED TRIAL; PROPHYLAXIS; DIAGNOSIS; PLATELETS AB Deep venous thrombosis and pulmonary emboli are reported to occur in up to 66% of the patients undergoing a major urological operation. Thromboembolic stockings, external sequential pneumatic compression stockings and anticoagulant agents, such as heparin sodium plus dihydroergotamine mesylate, have been suggested to decrease the risk of deep venous thrombosis and pulmonary emboli. A total of 74 evaluable patients undergoing a major urological operation was randomized to receive either thromboembolic stockings, external sequential pneumatic compression stockings, or heparin plus dihydroergotamine as prophylaxis against deep venous thrombosis and pulmonary emboli. Indium-111-labeled platelet scans, performed preoperatively and on days 1, 3 and 6 postoperatively, were used to diagnose deep venous thrombosis and pulmonary emboli. Mean patient age was 63 years and all but 1 operation was performed for neoplastic disease. Deep venous thrombosis was detected in 5 of 25 patients (20%) with thromboembolic stockings, 3 of 24 (12.5%) with external sequential pneumatic compression stockings and 2 of 25 (8%) with heparin plus dihydroergotamine. There was no difference in blood loss or complications among the groups. Although statistical significance among the treatment groups was not reached in this study, the trend to a decrease in deep venous thrombosis and pulmonary emboli with external sequential pneumatic compression stockings and heparin plus dihydroergotamine, and an absence of an increase in morbidity in these groups supports the use of these modalities to decrease the morbidity and mortality of deep venous thrombosis and pulmonary emboli. C1 BROOKE ARMY MED CTR,DEPT SURG,RADIOL SERV,FT SAM HOUSTON,TX 78234. MERCY HOSP,DEPT INTENS CARE,PITTSBURGH,PA 15219. BROOKE ARMY MED CTR,DEPT SURG,UROL SERV,FT SAM HOUSTON,TX 78234. NR 18 TC 34 Z9 35 U1 0 U2 1 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-5347 J9 J UROLOGY JI J. Urol. PD JUN PY 1991 VL 145 IS 6 BP 1205 EP 1208 PG 4 WC Urology & Nephrology SC Urology & Nephrology GA FN923 UT WOS:A1991FN92300019 PM 2033693 ER PT J AU DUBEY, JP PORTER, SL HATTEL, AL KRADEL, DC TOPPER, MJ JOHNSON, L AF DUBEY, JP PORTER, SL HATTEL, AL KRADEL, DC TOPPER, MJ JOHNSON, L TI SARCOCYSTOSIS-ASSOCIATED CLINICAL ENCEPHALITIS IN A GOLDEN EAGLE (AQUILA-CHRYSAETOS) SO JOURNAL OF ZOO AND WILDLIFE MEDICINE LA English DT Article DE GOLDEN EAGLE; AQUILA-CHRYSAESTOS; SARCOCYSTIS; ENCEPHALITIS; SCHIZONTS; MEROZOITES; PROTOZOAN; PARASITE ID FALCATULA; PATHOGENESIS; BUDGERIGAR; PATHOLOGY AB A golden eagle (Aquila chrysaetos) had a slight head tilt for several months. After 18 mo in captivity, the eagle died and was necropsied. The main lesion was meningoencephalitis, characterized by necrosis of neuropil, vasculitis, and mononuclear cell infiltration. The parasite divided by schizogony. Numerous schizonts were associated with blood vessels, were approximately 10-20 x 6-15-mu-m, and contained up to 20 merozoites. The parasites stained positively with Sarcocystis cruzi antiserum but not with Toxoplasma gondii and Neospora caninum antisera. This is apparently the first report of Sarcocystis encephalitis in a raptorial bird. C1 WILDLIFE CTR VIRGINIA,WEYERS CAVE,VA 24486. USA,MED RES INST INFECT DIS,FT DETRICK,MD 21702. PENN STATE UNIV,ANIM DIAGNOST LAB,UNIVERSITY PK,PA 16802. JOHNS HOPKINS UNIV,DIV COMPARAT MED,BALTIMORE,MD 21205. RP DUBEY, JP (reprint author), USDA ARS,BELTSVILLE AGR RES CTR,INST LIVESTOCK & POULTRY SCI,ZOONOT DIS LAB,BELTSVILLE,MD 20705, USA. NR 8 TC 22 Z9 22 U1 1 U2 5 PU AMER ASSOC Z00 VETERINARIANS PI MEDIA PA 6 NORTH PENNELL ROAD, MEDIA, PA 19063 SN 1042-7260 J9 J ZOO WILDLIFE MED JI J. Zoo Wildl. Med. PD JUN PY 1991 VL 22 IS 2 BP 233 EP 236 PG 4 WC Veterinary Sciences SC Veterinary Sciences GA FY141 UT WOS:A1991FY14100009 ER PT J AU ANDERSON, GW LAWRENCE, WB LEE, JO YOUNG, M AF ANDERSON, GW LAWRENCE, WB LEE, JO YOUNG, M TI A RESTRAINT FOR OPHTHALMIC EXAMINATION OF UNANESTHETIZED RATS SO LABORATORY ANIMAL SCIENCE LA English DT Note RP ANDERSON, GW (reprint author), USA,MED RES INST INFECT DIS,FREDERICK,MD 21701, USA. NR 1 TC 2 Z9 2 U1 0 U2 0 PU AMER ASSOC LABORATORY ANIMAL SCIENCE PI CORDOVA PA 70 TIMBERCREEK DR, SUITE 5, CORDOVA, TN 38018 SN 0023-6764 J9 LAB ANIM SCI JI Lab. Anim. Sci. PD JUN PY 1991 VL 41 IS 3 BP 288 EP 290 PG 3 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA GF778 UT WOS:A1991GF77800018 PM 1658475 ER PT J AU REUBEN, JM GONIK, B LI, S LOO, L TURPIN, J AF REUBEN, JM GONIK, B LI, S LOO, L TURPIN, J TI INDUCTION OF CYTOKINES IN NORMAL PLACENTAL CELLS BY THE HUMAN-IMMUNODEFICIENCY-VIRUS SO LYMPHOKINE AND CYTOKINE RESEARCH LA English DT Article ID TUMOR NECROSIS FACTOR; FACTOR-ALPHA; MONONUCLEAR PHAGOCYTES; HTLV-III/LAV; INFANTS BORN; TYPE-1 HIV-1; KAPPA-B; INTERLEUKIN-1; EXPRESSION; INFECTION AB Placental cotyledon mononuclear cells (CMC) resemble peripheral blood monocytes/macrophages (MM) with respect to their expression of surface antigens and cellular function. CMC also express the CD4 antigen receptor and are thus susceptible to infection with the human immunodeficiency virus (HIV). When vertical transmission of HIV from mother to fetus occurs, the infection often remains latent until appropriate factors initiate the transcription of virus-specific mRNA. Cytokines, such as interleukin-1-beta (IL-1-beta), tumor necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6) which are produced by MM, up-regulate HIV expression in infected cells. The induction of cytokines in MM does not require active infection with HIV since heat-inactivated HIV (iHIV) and envelope gp120 caused cytokine secretion. We studied the ability of CMC from normal placentas to secrete these cytokines following stimulation with endotoxin, iHIV, recombinant GP160 and GAG55, and synthetic p17, HGP-30. Whereas CMC spontaneously secreted low levels of IL-1-beta and TNF-alpha, they constitutively secreted high levels of IL-6. All cytokine levels could be boosted by endotoxin. GP160, iHIV, and HGP-30 failed to augment cytokine levels above baseline. In contrast, GAG55 significantly boosted only TNF-alpha. The relevance of these findings is discussed with respect to the putative roles of cytokines in the immunoregulation of HIV in utero. C1 WALTER REED ARMY MED CTR, DEPT CELLULAR IMMUNOL, KEY W MED CTR, ROCKVILLE, MD 20850 USA. UNIV TEXAS, DEPT OBSTET GYNECOL & REPROD SCI, HOUSTON, TX 77030 USA. RP REUBEN, JM (reprint author), UNIV TEXAS, MD ANDERSON HOSP & TUMOR INST, DIV LAB MED, 1515 HOLCOMBE BLVD, HOUSTON, TX 77030 USA. FU NIAID NIH HHS [1 U01 AI 27551-02]; NICHD NIH HHS [1 R01 HD 26603-01] NR 37 TC 18 Z9 18 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0277-6766 J9 LYMPHOKINE CYTOK RES JI Lymphokine Cytokine Res. PD JUN PY 1991 VL 10 IS 3 BP 195 EP 199 PG 5 WC Biochemistry & Molecular Biology; Immunology SC Biochemistry & Molecular Biology; Immunology GA FV119 UT WOS:A1991FV11900007 PM 1883914 ER PT J AU SIZEMORE, DR FINK, PS OU, JT BARON, L KOPECKO, DJ WARREN, RL AF SIZEMORE, DR FINK, PS OU, JT BARON, L KOPECKO, DJ WARREN, RL TI TN5 MUTAGENESIS OF THE SALMONELLA-TYPHIMURIUM 100 KB PLASMID - DEFINITION OF NEW VIRULENCE REGIONS SO MICROBIAL PATHOGENESIS LA English DT Note DE SALMONELLA-TYPHIMURIUM; VIRULENCE-ASSOCIATED PLASMID; TN5 MUTAGENESIS; VIRTN5; SPLENOMEGALY; LD50 ID SERUM RESISTANCE; CRYPTIC PLASMID; CLONING; GENES C1 WALTER REED ARMY MED CTR,DEPT BACTERIAL IMMUNOL,WASHINGTON,DC 20307. WRIGHT STATE UNIV,DEPT BIOL,DAYTON,OH 45435. WRIGHT STATE UNIV,DEPT MICROBIOL & IMMUNOL,DAYTON,OH 45435. NR 19 TC 19 Z9 19 U1 0 U2 0 PU ACADEMIC PRESS LTD PI LONDON PA 24-28 OVAL RD, LONDON, ENGLAND NW1 7DX SN 0882-4010 J9 MICROB PATHOGENESIS JI Microb. Pathog. PD JUN PY 1991 VL 10 IS 6 BP 493 EP 499 DI 10.1016/0882-4010(91)90116-R PG 7 WC Immunology; Microbiology SC Immunology; Microbiology GA GH332 UT WOS:A1991GH33200010 PM 1665537 ER PT J AU HALE, TL AF HALE, TL TI GENETIC-BASIS OF VIRULENCE IN SHIGELLA SPECIES SO MICROBIOLOGICAL REVIEWS LA English DT Review ID CONGO RED BINDING; ENTEROINVASIVE ESCHERICHIA-COLI; INTESTINAL EPITHELIAL-CELLS; HEMOLYTIC-UREMIC SYNDROME; CULTURED MAMMALIAN-CELLS; POSITIVE REGULATOR GENE; OUTER-MEMBRANE PROTEIN; PLASMID ANTIGEN GENE; FLEXNERI O-ANTIGENS; SHIGA-LIKE TOXINS AB Shigella species and enteroinvasive strains of Escherichia coli cause disease by invasion of the colonic epithelium, and this invasive phenotype is mediated by genes carried on 180- to 240-kb plasmids. In addition, at least eight loci on the Shigella chromosome are necessary for full expression of virulence. The products of these genes can be classified as (i) virulence determinants that directly affect the ability of shigellae to survive in the intestinal tissues, e.g., the aerobactin siderophore (iucABCD and iutA), superoxide dismutase (sodB), and somatic antigen expression (rfa and rfb); (ii) cytotoxins that contribute to the severity of disease, e.g., the Shiga toxin (stx) and a putative analog of this toxin (flu); and (iii) regulatory loci that affect the expression of plasmid genes, e.g., ompR-envZ, which mediates response to changes in osmolarity,virR (osmZ), which mediates response to changes in temperature, and kcpA, which affects the translation of the plasmid virG (icsA) gene which is associated with intracellular bacterial mobility and intracellular bacterial spread. A single plasmid regulatory gene (virF) controls a virulence-associated plasmid regulon including virG (icsA) and two invasion-related loci, i.e., (i) ipaABCD, encoding invasion plasmid antigens that may be structural components of the Shigella invasion determinant; and (ii) invAKJH (mxi), which is necessary for insertion of invasion plasmid antigens into the outer membrane. RP HALE, TL (reprint author), WALTER REED ARMY MED CTR,DEPT ENTER INFECT,WASHINGTON,DC 20307, USA. NR 173 TC 252 Z9 265 U1 2 U2 5 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0146-0749 J9 MICROBIOL REV JI Microbiol. Rev. PD JUN PY 1991 VL 55 IS 2 BP 206 EP 224 PG 19 WC Microbiology SC Microbiology GA FP775 UT WOS:A1991FP77500002 PM 1886518 ER PT J AU NORTON, AR AF NORTON, AR TI LEBANON AFTER TAIF - IS THE CIVIL-WAR OVER SO MIDDLE EAST JOURNAL LA English DT Article C1 US MIL ACAD,W POINT,NY 10996. NR 14 TC 4 Z9 4 U1 0 U2 3 PU MIDDLE EAST INSTITUTE PI WASHINGTON PA 1761 N STREET NW, CIRCULATION DEPT, WASHINGTON, DC 20036-2882 SN 0026-3141 J9 MIDDLE EAST J JI Middle East J. PD SUM PY 1991 VL 45 IS 3 BP 457 EP 473 PG 17 WC Area Studies SC Area Studies GA KZ387 UT WOS:A1991KZ38700004 ER PT J AU MILHIZER, ER AF MILHIZER, ER TI MURDER WITHOUT INTENT - DEPRAVED-HEART MURDER UNDER MILITARY LAW SO MILITARY LAW REVIEW LA English DT Article RP MILHIZER, ER (reprint author), USA,JUDGE ADVOCATE GEN SCH,DIV CRIMINAL LAW,CHARLOTTESVILLE,VA 22901, USA. NR 24 TC 1 Z9 1 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD SUM PY 1991 VL 133 BP 205 EP 248 PG 44 WC Law SC Government & Law GA GJ782 UT WOS:A1991GJ78200004 ER PT J AU ROLPH, JW AF ROLPH, JW TI FACING THE PHOENIX - THE CIA AND THE POLITICAL DEFEAT OF THE UNITED-STATES IN VIETNAM - GRANT,Z SO MILITARY LAW REVIEW LA English DT Book Review RP ROLPH, JW (reprint author), USA,JUDGE ADVOCATE GEN SCH,DIV INT LAW,CHARLOTTESVILLE,VA 22901, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD SUM PY 1991 VL 133 BP 349 EP 354 PG 6 WC Law SC Government & Law GA GJ782 UT WOS:A1991GJ78200007 ER PT J AU EMSWILER, TK AF EMSWILER, TK TI STALAG LUFT-III - THE SECRET STORY - DURAND,AA SO MILITARY LAW REVIEW LA English DT Book Review RP EMSWILER, TK (reprint author), USA,JUDGE ADVOCATE GEN SCH,DIV ADM & CIVIL LAW,CHARLOTTESVILLE,VA 22901, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD SUM PY 1991 VL 133 BP 355 EP 361 PG 7 WC Law SC Government & Law GA GJ782 UT WOS:A1991GJ78200008 ER PT J AU BORCH, FL AF BORCH, FL TI OPERATION DRUMBEAT - GANNON,M SO MILITARY LAW REVIEW LA English DT Book Review RP BORCH, FL (reprint author), USA,JUDGE ADVOCATE GEN SCH,DIV CRIMINAL LAB,CHARLOTTESVILLE,VA 22901, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD SUM PY 1991 VL 133 BP 362 EP 364 PG 3 WC Law SC Government & Law GA GJ782 UT WOS:A1991GJ78200009 ER PT J AU BATTAFARANO, DF JEFFERIES, B MCALLISTER, CK KELLY, JW AF BATTAFARANO, DF JEFFERIES, B MCALLISTER, CK KELLY, JW TI THE LACK OF UTILITY OF THE LATEX AGGLUTINATION-TEST FOR DETECTION OF CANDIDA ANTIGEN IN THE DIAGNOSIS OF SYSTEMIC CANDIDIASIS SO MILITARY MEDICINE LA English DT Article AB The Ramco latex agglutination test in the diagnosis of systemic candidiasis was utilized for 11 serum samples from 10 patients with systemic candidiasis, 21 serum samples from patients colonized with Candida species, and 20 control serum samples from patients with stable medical problems and no evidence of Candida albicans infection. This study was double-blind and the results of the latex agglutination test did not influence the decision for antifungal therapy. Nine of 10 patients with systemic candidiasis had positive titers (greater-than-or-equal-to 1:4); however, these were determined only 1 to 5 days before culture positivity. Nine of 21 (43%) of colonized patients were falsely positive (greater-than-or-equal-to 1:4) and all of the control samples were negative. The Ramco latex agglutination test was unreliable and inconsistent in this small sample group to establish an early diagnosis of systemic candidiasis. C1 BROOKE ARMY MED CTR,MDI,HSHE,DEPT MED,INFECT DIS SERV,BEACH PAVIL,FT SAM HOUSTON,TX 78234. NR 0 TC 4 Z9 4 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUN PY 1991 VL 156 IS 6 BP 283 EP 285 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA FP778 UT WOS:A1991FP77800012 PM 1852278 ER PT J AU SZLYK, PC ROSE, MS FRANCESCONI, RP MATTHEW, W SCHILLING, JD WHANG, R AF SZLYK, PC ROSE, MS FRANCESCONI, RP MATTHEW, W SCHILLING, JD WHANG, R TI CARBOHYDRATE-ELECTROLYTE SOLUTIONS DURING FIELD TRAINING - AN OVERVIEW SO MILITARY MEDICINE LA English DT Review AB The rationale and methods of evaluating two carbohydrate-electrolyte solutions at a field training exercise in hot weather are presented in this overview. The carbohydrate-electrolyte solutions were formulated to produce a multipurpose replacement beverage which could satisfy diverse requirements of troops working in hot climates. Several uses of these beverages include replacement of electrolytes and fluid while in Mission Oriented Protective Posture IV, fluid replacement for mild heat casualties, and oral rehydration therapy for treatment of diarrheal losses. RP SZLYK, PC (reprint author), USA,ENVIRONM MED RES INST,DIV HEAT RES,NATICK,MA 01760, USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUN PY 1991 VL 156 IS 6 BP 305 EP 308 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA FP778 UT WOS:A1991FP77800017 PM 1852283 ER PT J AU STONG, GC MASON, KT AF STONG, GC MASON, KT TI MEDICAL EVACUATION IN A LOW INTENSITY CONFLICT ENVIRONMENT SO MILITARY MEDICINE LA English DT Article AB Medical evacuation is one of the major missions of the Medical Element, Joint Task Force-Bravo (ME-JTF-B) in Honduras, which operates in a low intensity conflict environment. ME-JTF-B conducted 10 missions during the primary author's deployment. Critical examination of these missions led to several performance improvements. The most important is that of deploying on all missions an emergency medical evaluation team with TACSAT (a field portable transmitter-receiver which can communicate via satellite over long distances). The second most important is that of close command and control of every mission by the hospital commander and the chief administrator. Other performance improvements are listed below. RP STONG, GC (reprint author), USA,ARMY MED CTR,DEPT PATHOL,FT RUCKER,AL 36362, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUN PY 1991 VL 156 IS 6 BP 308 EP 310 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA FP778 UT WOS:A1991FP77800018 PM 1852284 ER PT J AU GUNDERSON, CH WORTZEL, C AF GUNDERSON, CH WORTZEL, C TI IMPACT OF THE NEW FITNESS REGULATION FOR EPILEPSY SO MILITARY MEDICINE LA English DT Article AB In 1983, a new regulation was prepared, based on clinical reports published at that time, redefining the fitness standards for those applicants to the military who had experienced one or more seizures during childhood or early adult life. The most important change admitted those who had been free of seizures and off medications for 5 years or more and who had normal EEGs. Only 2 of 155 soldiers enlisted in 1986 and 1987 meeting these criteria were separated for seizure-related complaints. Both had problems during basic training and the diagnosis of recurrent epilepsy was tenuous in both. We conclude that the regulation change has given many young adults a chance to serve effectively in the Army without appreciable increase in medical or training costs. RP GUNDERSON, CH (reprint author), WALTER REED ARMY MED CTR,NEUROL SERV,WASHINGTON,DC 20307, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUN PY 1991 VL 156 IS 6 BP 315 EP 317 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA FP778 UT WOS:A1991FP77800021 PM 1852287 ER PT J AU LAPIANA, FG AF LAPIANA, FG TI MEDICAL UNITS - WHO SHOULD COMMAND SO MILITARY MEDICINE LA English DT Letter RP LAPIANA, FG (reprint author), USA,DIV OPHTHALMOL,WASHINGTON,DC 20310, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUN PY 1991 VL 156 IS 6 BP A9 EP A9 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA FP778 UT WOS:A1991FP77800007 PM 1852273 ER PT J AU MOORE, RG AF MOORE, RG TI MEDICAL UNITS - WHO SHOULD COMMAND SO MILITARY MEDICINE LA English DT Letter RP MOORE, RG (reprint author), USA,DEPT COMMANDER CLIN SERV,WASHINGTON,DC 20310, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD JUN PY 1991 VL 156 IS 6 BP A8 EP A8 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA FP778 UT WOS:A1991FP77800005 ER PT J AU OMEARA, NT SOLAND, RM AF OMEARA, NT SOLAND, RM TI OPTIMAL STRATEGIES FOR PROBLEMS OF SIMULTANEOUS ATTACK AGAINST AN AREA DEFENSE WITHOUT IMPACT-POINT PREDICTION SO NAVAL RESEARCH LOGISTICS LA English DT Article ID PREALLOCATED PREFERENTIAL DEFENSE AB An area to be defended consists of separated point targets. These targets are subject to an attack in which the offensive weapons are assumed to arrive simultaneously. The defense has area defenders, each of which is capable of intercepting any attacker. The defense has no impact-point prediction; that is, it has no knowledge of any attacker's destination prior to allocation of area interceptors. For a given attack, the defense wishes to allocate its interceptors to maximize the total expected survival value of the targets. For a given attack size, the offense seeks a strategy to minimize total expected surviving value against best defense. We determine an optimal defensive strategy directly and develop an algorithm to determine an optimal attack and the optimal value of the min-max problem. A dynamic programming technique is used to obtain integer solutions, and illustrative computational results are provided. C1 GEORGE WASHINGTON UNIV,SCH ENGN & APPL SCI,DEPT OPERAT RES,WASHINGTON,DC 20052. RP OMEARA, NT (reprint author), USA,STRATEG DEF COMMAND,ARLINGTON,VA 22215, USA. NR 17 TC 3 Z9 3 U1 0 U2 0 PU JOHN WILEY & SONS INC PI NEW YORK PA 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0894-069X J9 NAV RES LOG JI Nav. Res. Logist. PD JUN PY 1991 VL 38 IS 3 BP 289 EP 302 DI 10.1002/1520-6750(199106)38:3<289::AID-NAV3220380302>3.0.CO;2-Q PG 14 WC Operations Research & Management Science SC Operations Research & Management Science GA FG592 UT WOS:A1991FG59200001 ER PT J AU FINE, BJ AF FINE, BJ TI FIELD-DEPENDENCE AND EXTROVERSION - UNIVARIATE OR MULTIVARIATE RESEARCH ORIENTATION SO PERCEPTUAL AND MOTOR SKILLS LA English DT Article ID EYSENCK RP FINE, BJ (reprint author), USA,ENVIRONM MED RES INST,NATICK,MA 01760, USA. NR 16 TC 5 Z9 5 U1 0 U2 0 PU PERCEPTUAL MOTOR SKILLS PI MISSOULA PA PO BOX 9229, MISSOULA, MT 59807 SN 0031-5125 J9 PERCEPT MOTOR SKILL JI Percept. Mot. Skills PD JUN PY 1991 VL 72 IS 3 BP 1044 EP 1046 PN 1 PG 3 WC Psychology, Experimental SC Psychology GA FV007 UT WOS:A1991FV00700057 ER PT J AU KANT, GJ WRIGHT, WL ROBINSON, TN DANGELO, CP AF KANT, GJ WRIGHT, WL ROBINSON, TN DANGELO, CP TI EFFECTS OF MK-801 ON LEARNING AND MEMORY AS ASSESSED USING A NOVEL WATER MAZE SO PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR LA English DT Article DE MK-801; N-METHYL-D-ASPARTATE (NMDA); WATER MAZE; LEARNING; MEMORY ID LONG-TERM POTENTIATION; METHYL-D-ASPARTATE; LINKED HEMOGLOBIN SOLUTION; RECEPTOR ANTAGONISTS; NMDA RECEPTORS; RATS; PERFORMANCE; ACQUISITION; ANTICONVULSANT; IMPAIRMENT AB The effects of the NMDA receptor antagonist MK-801 {(+)-10,11-dihydro-5-methyl-5H-dibenzo [a,d]-cyclohepten-5,10 imine hydrogen maleate} on learning and memory were assessed using a water maze. The maze was a traditional type of maze with alleys and choices between various paths, but set inside a pool of water to a height of 25 cm. Different mazes could be configured by altering the arrangement of open vs. closed doors. Both the time required to reach an out-of-the-water exit platform and the errors made during the swim from start to finish were recorded. Learning was assessed during the first 10 to 20 trials in a new maze configuration, while memory was tested after the maze was well learned. Three experiments, some with several phases, were performed. These experiments compared the effects of 0.1 mg/kg of either (+)-MK-801, or (-)-MK-801 vs. saline on learning new maze configurations as well as swimming well-learned mazes. Neither of the MK-801 isomers impaired performance of a previously learned maze. (+)-MK-801 clearly slowed learning of new mazes as measured by both maze completion time and errors committed, while (-)-MK-801 had a significant but smaller effect on learning. Rats given (+)- or (-)-MK-801 (0.1 mg/kg) for 16 days while learning one maze and then challenged to learn a new maze without drug administration performed no differently on the new maze than controls, suggesting that the acute effect of MK-801 on learning is not long lasting. RP KANT, GJ (reprint author), WALTER REED ARMY MED CTR,DEPT MED NEUROSCI,WASHINGTON,DC 20307, USA. NR 29 TC 46 Z9 46 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0091-3057 J9 PHARMACOL BIOCHEM BE JI Pharmacol. Biochem. Behav. PD JUN PY 1991 VL 39 IS 2 BP 479 EP 485 DI 10.1016/0091-3057(91)90212-K PG 7 WC Behavioral Sciences; Neurosciences; Pharmacology & Pharmacy SC Behavioral Sciences; Neurosciences & Neurology; Pharmacology & Pharmacy GA FZ846 UT WOS:A1991FZ84600038 PM 1946588 ER PT J AU SLINEY, DH KRUEGER, RR TROKEL, SL RAPPAPORT, KD AF SLINEY, DH KRUEGER, RR TROKEL, SL RAPPAPORT, KD TI PHOTOKERATITIS FROM 193NM ARGON-FLUORIDE LASER-RADIATION SO PHOTOCHEMISTRY AND PHOTOBIOLOGY LA English DT Article; Proceedings Paper CT SPECIAL SYMP AT THE 18TH ANNUAL MEETING OF THE AMERICAN SOC FOR PHOTOBIOLOGY : LASERS IN MEDICINE CY JUN, 1990 CL VANCOUVER, CANADA SP AMER SOC PHOTOBIOL ID ULTRAVIOLET-RADIATION; EXCIMER LASER; CORNEA; DAMAGE; ENDOTHELIUM; RABBIT AB The threshold for photokeratitis at 193 nm was obtained for the rabbit cornea using an ArF excimer laser. Because ablation occurs at a level below that for photokeratitis, it was necessary to expose the cornea to a lengthy series of low-energy exposures. It is concluded that the 193 nm photons have such a shallow penetration depth, being limited to the outermost epithelial cells, that classical photokeratitis occurs from the fluorescence emitted at the corneal epithelial absorption site. An intact tear film may helpe to protect the cornea from low-level, scattered 193 nm laser radiation. C1 MCGILL UNIV,MONTREAL H3A 1B1,QUEBEC,CANADA. COLUMBIA PRESBYTERIAN MED CTR,HARKNESS EYE INST,NEW YORK,NY 10032. RP SLINEY, DH (reprint author), USA,ENVIRONM HYG AGCY,DIV LASER MICROWAVE,ABERDEEN PROVING GROUND,MD 21010, USA. NR 27 TC 17 Z9 17 U1 0 U2 1 PU AMER SOC PHOTOBIOLOGY PI AUGUSTA PA BIOTECH PARK, 1021 15TH ST, SUITE 9, AUGUSTA, GA 30901-3158 SN 0031-8655 J9 PHOTOCHEM PHOTOBIOL JI Photochem. Photobiol. PD JUN PY 1991 VL 53 IS 6 BP 739 EP 744 PG 6 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA FN605 UT WOS:A1991FN60500003 PM 1886933 ER PT J AU VANDERBEEK, CJ KES, PH AF VANDERBEEK, CJ KES, PH TI DISLOCATION-MEDIATED FLUX CREEP IN BI2SR2CACU2O8+DELTA SO PHYSICAL REVIEW B LA English DT Article ID HIGH-TC SUPERCONDUCTORS; SINGLE-CRYSTAL BI2SR2CACU2O8; II SUPERCONDUCTORS; IRREVERSIBILITY LINE; PENETRATION DEPTH; LATTICE; FLOW; DEPENDENCE; FIELD; FILM AB We have investigated the possible role of two-dimensional vortex-lattice defects in thermally assisted flux flow for the very anisotropic high-temperature superconductor Bi2Sr2CaCu2O8+delta (Bi-Sr-Ca-Cu-O). At low current densities, this mechanism, which we shall refer to as plastic flux creep, is expected to prevail over creep of elastically correlated flux bundles, or elastic creep. It is assumed that vortices are pinned by oxygen vacancies, for which the elementary interaction is obtained. Measurements of the ac susceptibility in an applied dc field, B(c1) < mu-0H < 0.2B(c2), carried out using a sufficiently low driving-field amplitude, were performed on a Bi-Sr-Ca-Cu-O single-crystalline sample It is shown that under the above assumptions the experimental data may be consistently interpreted. The field dependence of the activation barrier is explained. Furthermore, the irreversibility line is reproduced, as well as the shape of the ac-susceptibility transition. Deviations from the plastic-flux-creep model can be qualitatively understood using a criterion describing the crossover to elastic flux creep. C1 UNIV CALIF LOS ALAMOS SCI LAB,ERDC,LOS ALAMOS,NM 87545. RP VANDERBEEK, CJ (reprint author), LEIDEN STATE UNIV,KAMERLINGH ONNES LAB,POB 9506,2312 AV LEIDEN,NETHERLANDS. NR 44 TC 140 Z9 140 U1 1 U2 3 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0163-1829 J9 PHYS REV B JI Phys. Rev. B PD JUN 1 PY 1991 VL 43 IS 16 BP 13032 EP 13041 DI 10.1103/PhysRevB.43.13032 PN A PG 10 WC Physics, Condensed Matter SC Physics GA FP631 UT WOS:A1991FP63100042 ER PT J AU LITTLEFIELD, DL AF LITTLEFIELD, DL TI FINITE CONDUCTIVITY EFFECTS ON THE MHD INSTABILITIES IN UNIFORMLY ELONGATING PLASTIC JETS SO PHYSICS OF FLUIDS A-FLUID DYNAMICS LA English DT Article AB The effect of finite electrical conductivity on the stability of perfectly plastic jets is considered. Application of the analysis to shaped-charge jets is of primary interest. The jet is assumed to be uniformly elongating and axisymmetric. An axial electric current is introduced in the jet at time t = 0 and permitted to diffuse over time. After base solutions to the relevant governing equations are calculated, the stability characteristics of the jet are determined using linear perturbation theory. Solutions to the first-order equations indicate that disturbances in the magnetic field and pressure distributions vary significantly depending on the conductivity. The growth rate in the boundary perturbation, however, demonstrates that jets of finite conductivity are only slightly more stable than equivalent jets of infinite conductivity. The behavior of these instabilities is discussed in terms of the applicable physical mechanisms. RP LITTLEFIELD, DL (reprint author), USA,BALLIST RES LABS,ABERDEEN PROVING GROUND,MD 21005, USA. NR 9 TC 9 Z9 13 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0899-8213 J9 PHYS FLUIDS A-FLUID PD JUN PY 1991 VL 3 IS 6 BP 1666 EP 1673 DI 10.1063/1.857945 PG 8 WC Mechanics; Physics, Fluids & Plasmas SC Mechanics; Physics GA FN767 UT WOS:A1991FN76700020 ER PT J AU GRAHAM, DO AF GRAHAM, DO TI SDI - SOME PROGRESS BETTER THAN NONE SO POLICY REVIEW LA English DT Letter RP GRAHAM, DO (reprint author), USA,ARLINGTON,VA 22209, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU HERITAGE FOUNDATION PI WASHINGTON PA 214 MASSACHUSETTS AVE NE, WASHINGTON, DC 20002 SN 0146-5945 J9 POLICY REV JI Policy Rev. PD SUM PY 1991 VL 57 BP 91 EP 92 PG 2 WC Political Science SC Government & Law GA GL818 UT WOS:A1991GL81800026 ER PT J AU FAVA, M LITTMAN, A HALPERIN, P PRATT, E DREWS, FR OLESHANSKY, M KNAPIK, J THOMPSON, C BIELENDA, C AF FAVA, M LITTMAN, A HALPERIN, P PRATT, E DREWS, FR OLESHANSKY, M KNAPIK, J THOMPSON, C BIELENDA, C TI PSYCHOLOGICAL AND BEHAVIORAL BENEFITS OF A STRESS TYPE-A BEHAVIOR REDUCTION PROGRAM FOR HEALTHY MIDDLE-AGED ARMY OFFICERS SO PSYCHOSOMATICS LA English DT Article ID DISEASE; POPULATION AB Twenty army officers who participated in a stress/type A behavior reduction program and a comparison group of 17 officer nonparticipants volunteered to undergo a battery of psychological and behavioral tests before and after the program. Following the program, participants displayed a significantly greater reduction in average daily caloric intake and levels of perceived stress, anxiety, hostility, depression, psychological distress, and type A behavior as compared to the officers who did not participate in it. Given the fact that most of these psychological and behavioral factors have been found in previous studies to be related to an increased risk for coronary artery disease, it seems that the changes reported by the participants in the program are potentially healthful. C1 USA,COLL WAR,CARLISLE,PA. MASSACHUSETTS GEN HOSP,DEPT PREVENT MED,BOSTON,MA 02114. RP FAVA, M (reprint author), MASSACHUSETTS GEN HOSP,DEPT PSYCHIAT ACC-815,BOSTON,MA 02114, USA. NR 15 TC 17 Z9 17 U1 2 U2 3 PU AMER PSYCHIATRIC ASSOCIATION PI WASHINGTON PA 1400 K ST NW, WASHINGTON, DC 20005 SN 0033-3182 J9 PSYCHOSOMATICS JI Psychosomatics PD SUM PY 1991 VL 32 IS 3 BP 337 EP 342 PG 6 WC Psychiatry; Psychology SC Psychiatry; Psychology GA FU214 UT WOS:A1991FU21400012 PM 1882025 ER PT J AU MEYER, CA MIRVIS, SE WOLF, AL THOMPSON, RK GUTIERREZ, MA AF MEYER, CA MIRVIS, SE WOLF, AL THOMPSON, RK GUTIERREZ, MA TI ACUTE TRAUMATIC MIDBRAIN HEMORRHAGE - EXPERIMENTAL AND CLINICAL OBSERVATIONS WITH CT SO RADIOLOGY LA English DT Article DE BRAIN, CT; BRAIN, HEMORRHAGE; BRAIN, INFARCTION; BRAIN, INJURIES; MENINGES, INJURIES ID BRAIN-STEM HEMORRHAGE; DIFFUSE AXONAL INJURY; COMPUTERIZED-TOMOGRAPHY; HEAD TRAUMA; MR; LESIONS; SCANS AB Traumatic brain stem hemorrhage (TBH) after blunt head impact is an uncommon injury and has historically been associated with high mortality. Retrospective clinical review identified 64 patients with TBH admitted during a 5-year period. Complete imaging and clinical records for 45 of these patients demonstrated that TBH could be categorized into three groups. The most frequent site of hemorrhage, in 31 (69%) of 45 patients (group 1), was the midline rostral anterior brain stem, posterior to the interpeduncular cistern, and this injury was associated with a 71% survival rate. This pattern was also associated with a predominantly anterior site of head and/or face impact. Eight (18%) patients (group 2) had miscellaneous foci of acute brain stem hemorrhage, with seven (88%) surviving. Six (13%) patients (group 3) had brain stem hemorrhage associated with transtentorial herniation and brain stem compression, with 100% mortality. Experimental findings in a canine model and clinical results indicate that the anterior rostral midbrain is a common site of TBH and appears to arise from sudden craniocaudal displacement of the brain at impact. Survival is unexpectedly high with this location of traumatic midbrain hemorrhage. C1 MARYLAND INST EMERGENCY MED SERV SYST,DEPT RADIOL,22 S GREENE ST,BALTIMORE,MD 21202. MARYLAND INST EMERGENCY MED SERV SYST,DEPT NEUROSURG,BALTIMORE,MD 21202. WALTER REED ARMY MED CTR,DEPT RADIOL,WASHINGTON,DC 20307. UNIV MARYLAND,MED CTR,DIV NEUROSURG,BALTIMORE,MD 21201. NR 31 TC 14 Z9 14 U1 0 U2 0 PU RADIOLOGICAL SOC NORTH AMER PI EASTON PA 20TH AND NORTHAMPTON STS, EASTON, PA 18042 SN 0033-8419 J9 RADIOLOGY JI Radiology PD JUN PY 1991 VL 179 IS 3 BP 813 EP 818 PG 6 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA FM910 UT WOS:A1991FM91000045 PM 2027997 ER PT J AU KIM, BJ GEE, CS BANDY, JT HUANG, CS AF KIM, BJ GEE, CS BANDY, JT HUANG, CS TI HAZARDOUS-WASTE TREATMENT TECHNOLOGIES SO RESEARCH JOURNAL OF THE WATER POLLUTION CONTROL FEDERATION LA English DT Review ID CONTAMINATED SOIL; FIELD DEMONSTRATION; REMEDIATION; BIOREMEDIATION; INCINERATION; SITE; PENTACHLOROPHENOL; DETOXIFICATION; COMBUSTION; OXIDATION RP KIM, BJ (reprint author), USA,CONSTRUCT ENGN RES LAB,POB 4005,CHAMPAIGN,IL 61824, USA. NR 166 TC 7 Z9 7 U1 0 U2 0 PU WATER ENVIRONMENT FEDERATION PI ALEXANDRIA PA 601 WYTHE ST, ALEXANDRIA, VA 22314-1994 SN 1047-7624 J9 RES J WATER POLLUT C PD JUN PY 1991 VL 63 IS 4 BP 501 EP 509 PG 9 WC Environmental Sciences; Limnology; Water Resources SC Environmental Sciences & Ecology; Marine & Freshwater Biology; Water Resources GA FR368 UT WOS:A1991FR36800034 ER PT J AU COHEN, SH SEGARS, RA AF COHEN, SH SEGARS, RA TI THIN SECTIONING OF CARBONACEOUS ADSORBENT SPHERES FOR VISUALIZATION BY LIGHT-MICROSCOPY AND SCANNING ELECTRON-MICROSCOPY SO SCANNING MICROSCOPY LA English DT Article DE SCANNING ELECTRON MICROSCOPY; LIGHT MICROSCOPY; ULTRAMICROTOMY; CARBONACEOUS ADSORBENT SPHERES; XE-340; XE-347; XE-348; SURFACE AREA; GAS ADSORPTION AB Three different types of Rohm and Haas carbonaceous adsorbent spheres (XE-340, XE-347 and XE-348) were prepared for light and scanning electron microscopy by embedding in resin and by thin sectioning. Spurr's low viscosity resin, because or its penetrating and wetting ability, contributed to the production of the most uniform and artifact free thin sections. In addition to thin sectioning, gas adsorption surface area measurements were made on batches of each type of sphere. There was an apparent relationship between the surface area measurements of 417.8 m2/g for XE-340, 583.4 m2/g for XE-347 and 752.9 m2/g for XE-348 and the microstructural appearances of the internal morphologies of each type of sphere. RP COHEN, SH (reprint author), USA,NATICK RES DEV & ENERGY LABS,SCI & ADV TECH LAB,NATICK,MA 01760, USA. NR 2 TC 1 Z9 1 U1 0 U2 2 PU SCANNING MICROSCOPY INT PI CHICAGO PA PO BOX 66507, AMF O'HARE, CHICAGO, IL 60666 SN 0891-7035 J9 SCANNING MICROSCOPY JI Scanning Microsc. PD JUN PY 1991 VL 5 IS 2 BP 363 EP 367 PG 5 WC Microscopy SC Microscopy GA GC670 UT WOS:A1991GC67000008 ER PT J AU BERNARD, EF HASE, T AF BERNARD, EF HASE, T TI GROWING AND INSITU PROCESSING OF CELLS ON BEEM CAPSULE CAPS FOR SCANNING ELECTRON-MICROSCOPY SO SCANNING MICROSCOPY LA English DT Article DE AIDS VIRUS; BEEM CAPSULE CAP; CELL CULTURE; COLIBACILLI; ERYTHROCYTE SICKLING; GONOCOCCI; HUMAN POLYMORPHONUCLEAR LEUKOCYTES; INSITU PROCESSING; LEISHMANIA; MOUSE SPLENIC CELLS; TRYPANOSOMA ID LIGHT AB A simple technique for processing cells grown on BEEM capsule caps for scanning electron microscopic (SEM) observation is described. The cells adhere to a substratum on the inner surface of caps coated with either an egg white-polyvinylpyrrolidone solution or a polylysine solution in the case of eukaryotic cells and an agar solution in the case of bacteria. The adhering cells are cultured and then processed in situ for SEM observation. Electron micrographs revealed details of the shape of the cells growing on the surface of the substrate. The technique seems to be particularly well suited for observing sequential morphological changes of cells, bacteria, and protozoa cultured under a specified experimental condition as well as of interactions between cells and parasitic microorganisms. C1 WALTER REED ARMY MED CTR,DEPT ULTRASTRUCTURAL PATHOL,DIV PATHOL,WASHINGTON,DC 20307. NR 4 TC 1 Z9 1 U1 0 U2 1 PU SCANNING MICROSCOPY INT PI CHICAGO PA PO BOX 66507, AMF O'HARE, CHICAGO, IL 60666 SN 0891-7035 J9 SCANNING MICROSCOPY JI Scanning Microsc. PD JUN PY 1991 VL 5 IS 2 BP 595 EP 599 PG 5 WC Microscopy SC Microscopy GA GC670 UT WOS:A1991GC67000028 PM 1947942 ER PT J AU ADVANI, AH THADHANI, NN GREBE, HA HEAPS, R COFFIN, C KOTTKE, T AF ADVANI, AH THADHANI, NN GREBE, HA HEAPS, R COFFIN, C KOTTKE, T TI DYNAMIC MODELING OF SELF PROPAGATING HIGH-TEMPERATURE SYNTHESIS OF TITANIUM CARBIDE CERAMICS SO SCRIPTA METALLURGICA ET MATERIALIA LA English DT Article ID COMBUSTION C1 UNIV TEXAS,DEPT MET & MAT ENGN,EL PASO,TX 79968. NEW MEXICO INST MIN & TECHNOL,SOCORRO,NM 87801. USA,BALLIST RES LABS,ABERDEEN PROVING GROUND,MD 21005. RP ADVANI, AH (reprint author), UNIV TEXAS,INST MFG & MAT MANAGEMENT,EL PASO,TX 79968, USA. NR 13 TC 7 Z9 7 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0956-716X J9 SCRIPTA METALL MATER JI Scr. Metall. Materialia PD JUN PY 1991 VL 25 IS 6 BP 1447 EP 1452 DI 10.1016/0956-716X(91)90431-Y PG 6 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA FP093 UT WOS:A1991FP09300040 ER PT J AU ZUKAS, WX CRAVEN, KJ WENTWORTH, SE AF ZUKAS, WX CRAVEN, KJ WENTWORTH, SE TI EFFECTS OF ALUMINUM-OXIDE SURFACES ON EPOXY CURE REACTIONS SO SURFACE AND INTERFACE ANALYSIS LA English DT Article; Proceedings Paper CT INTERNATIONAL CONF ON ADHESION AND SURFACE ANALYSIS CY APR 03-05, 1990 CL LOUGHBOROUGH UNIV, LOUGHBOROUGH, ENGLAND HO LOUGHBOROUGH UNIV RP ZUKAS, WX (reprint author), USA,MAT TECHNOL LAB,WATERTOWN,MA 02172, USA. NR 5 TC 4 Z9 4 U1 1 U2 1 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0142-2421 J9 SURF INTERFACE ANAL JI Surf. Interface Anal. PD JUN PY 1991 VL 17 IS 7 BP 530 EP 532 DI 10.1002/sia.740170722 PG 3 WC Chemistry, Physical SC Chemistry GA FV520 UT WOS:A1991FV52000021 ER PT J AU ROTHMAN, RB BYKOV, V MAHBOUBI, A LONG, JB JIANG, Q PORRECA, F DECOSTA, BR JACOBSON, AE RICE, KC HOLADAY, JW AF ROTHMAN, RB BYKOV, V MAHBOUBI, A LONG, JB JIANG, Q PORRECA, F DECOSTA, BR JACOBSON, AE RICE, KC HOLADAY, JW TI INTERACTION OF BETA-FUNALTREXAMINE WITH [H-3] CYCLOFOXY BINDING IN RAT-BRAIN - FURTHER EVIDENCE THAT BETA-FNA ALKYLATES THE OPIOID RECEPTOR COMPLEX SO SYNAPSE LA English DT Article DE BETA-FNA; OPIOID RECEPTORS; ALKYLATING AGENTS; [H-3][D-ALA2,D-LEU5] ENKEPHALIN; CYCLOFOXY ID POSITRON EMISSION TOMOGRAPHY; SITE INTERACTIONS INVITRO; 2-SITE ALLOSTERIC MODEL; KAPPA-OPIATE RECEPTOR; MU-RECOGNITION SITE; GUINEA-PIG BRAIN; DELTA-RECEPTOR; ENANTIOSPECIFIC ACYLATION; FENTANYL ISOTHIOCYANATE; LEUCINE-H-3 ENKEPHALIN AB beta-Funaltrexamine (beta-FNA) is an alkylating derivative of naltrexone. In addition to acting as an irreversible inhibitor of mu-receptor-mediated physiological effects, intracerebroventricular (i.c.v.) administration of beta-FNA to rat attenuates the ability of selective delta receptor antagonists and naloxone to reverse delta receptor-mediated effects. Moreover, recent work demonstrated that i.c.v. administration of beta-FNA alters the conformation of the opioid receptor complex, as inferred by a decrease in the Bmax of the lower affinity [H-3][D-ala2,D-leu5]enkephalin binding site. Consistent with the decreased potency of naloxone as an inhibitor of delta receptor mediated effects, beta-FNA doubled the naloxone IC50 for displacing [H-3][D-ala2,D-leu5]enkephalin from its lower affinity binding site. These data collectively support the hypothesis that the opioid receptor complex postulated to mediate mu-delta interactions in vivo is identical to the opioid receptor complex as defined by vitro ligand binding studies. A direct prediction of this hypothesis is that beta-FNA should increase the Kd of antagonists for the mu binding site (mu-cx) of the receptor complex. The data reported in this paper demonstrate that beta-FNA doubled the IC50 of the potent narcotic antagonist, 6-desoxy-6-beta-fluoronaltrexone (cycloFOXY) for displacing [H-3][D-ala2,D-leu5]enkephalin from its lower affinity binding site, and doubled the Kd of [H-3]cycloFOXY for its mu binding site, providing additional data that the mu binding site labeled by [H-3]cycloFOXY is the mu binding site of the opioid receptor complex. beta-FNA also altered the kappa binding site labeled by [H-3]cycloFOXY, and when administered intrathecally to mice, beta-FNA produced a longlasting antinociception in the acetic acid writhing test. C1 WALTER REED ARMY MED CTR,DIV MED NEUROSCI,NEUROPHARMACOL BRANCH,WASHINGTON,DC 20307. UNIV ARIZONA,COLL MED,DEPT PHARMACOL,TUCSON,AZ 85724. NIDDK,MED CHEM LAB,DRUG DESIGN & SYNTHESIS SECT,BETHESDA,MD 20892. MEDICIS CORP,NEW YORK,NY 10017. RP ROTHMAN, RB (reprint author), NIDDK,MED CHEM LAB,RECEPTOR STUDIES UNIT,BETHESDA,MD 20892, USA. NR 62 TC 26 Z9 26 U1 0 U2 1 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0887-4476 J9 SYNAPSE JI Synapse PD JUN PY 1991 VL 8 IS 2 BP 86 EP 99 DI 10.1002/syn.890080203 PG 14 WC Neurosciences SC Neurosciences & Neurology GA FN214 UT WOS:A1991FN21400002 PM 1652797 ER PT J AU SHIRAKO, Y NIKLASSON, B DALRYMPLE, JM STRAUSS, EG STRAUSS, JH AF SHIRAKO, Y NIKLASSON, B DALRYMPLE, JM STRAUSS, EG STRAUSS, JH TI STRUCTURE OF THE OCKELBO VIRUS GENOME AND ITS RELATIONSHIP TO OTHER SINDBIS VIRUSES SO VIROLOGY LA English DT Article ID NUCLEOTIDE-SEQUENCE; SUBGENOMIC RNA; KARELIAN FEVER; NEONATAL MICE; MUTATIONS; REGION; ENCEPHALOMYELITIS; NEUROVIRULENCE; PATHOGENESIS; ALPHAVIRUSES C1 CALTECH,DIV BIOL,PASADENA,CA 91125. NATL BACTERIOL LAB,DEPT VIROL,S-10521 STOCKHOLM,SWEDEN. NATL DEF RES ESTAB FAO-5,S-17290 SUNDBYBERG,SWEDEN. USA,MED RES INST INFECT DIS,DIV VIROL,FREDERICK,MD 21702. FU NIAID NIH HHS [AI 10793] NR 48 TC 67 Z9 71 U1 0 U2 2 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0042-6822 J9 VIROLOGY JI Virology PD JUN PY 1991 VL 182 IS 2 BP 753 EP 764 DI 10.1016/0042-6822(91)90616-J PG 12 WC Virology SC Virology GA FM141 UT WOS:A1991FM14100034 PM 1673813 ER PT J AU JAMES, WP KIM, KW AF JAMES, WP KIM, KW TI A DISTRIBUTED DYNAMIC WATERSHED MODEL - REPLY SO WATER RESOURCES BULLETIN LA English DT Discussion C1 CORPS ENGINEERS,WATERWAYS EXPT STN,VICKSBURG,MS 39180. RP JAMES, WP (reprint author), TEXAS A&M UNIV SYST,COLLEGE STN,TX 77843, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER WATER RESOURCES ASSOC PI HERNDON PA 950 HERNDON PARKWAY SUITE 300, HERNDON, VA 22070-5528 SN 0043-1370 J9 WATER RESOUR BULL JI Water Resour. Bull. PD JUN PY 1991 VL 27 IS 3 BP 551 EP 551 PG 1 WC Engineering, Civil; Geosciences, Multidisciplinary; Water Resources SC Engineering; Geology; Water Resources GA GR495 UT WOS:A1991GR49500021 ER PT J AU WARREN, WL RONG, FC POINDEXTER, EH KANICKI, J GERARDI, GJ AF WARREN, WL RONG, FC POINDEXTER, EH KANICKI, J GERARDI, GJ TI LOW-TEMPERATURE ELECTRON-SPIN-RESONANCE INVESTIGATIONS OF SILICON PARAMAGNETIC DEFECTS IN SILICON-NITRIDE SO APPLIED PHYSICS LETTERS LA English DT Article ID DANGLING-BOND CENTERS; AMORPHOUS-SILICON; CORRELATION-ENERGY; 1ST OBSERVATION; FILMS; ILLUMINATION; CHARGE; STATES AB We have reproduced and extended some recently reported electron spin resonance (ESR) measurements related to the nature of the dominant charge traps in silicon nitride. We detected defect centers at low temperatures using ESR, in both as-deposited and ultraviolet-irradiated silicon nitride powders and films prepared by low-pressure chemical vapor deposition (LPCVD). Only two silicon dangling bond defects were observed in the silicon nitride, one at g = 2.003 (.Si= N3), and the other at g = 2.005 (.Si= Si3). The signal intensity at g = 2.003 is by far the dominant signal in the LPCVD films and powders subjected to UV illumination; the signal at g = 2.005 is only about 3% of its intensity. These results support the idea that there is just one dominant silicon paramagnetic center (.Si = N3), which is responsible for charge trapping in silicon nitride. C1 USA,ELECTR TECHNOL & DEVICES LAB,FT MONMOUTH,NJ 07703. IBM CORP,THOMAS J WATSON RES CTR,DIV RES,YORKTOWN HTS,NY 10598. WILLIAM PATERSON STATE COLL,DEPT CHEM,WAYNE,NJ 07470. RP WARREN, WL (reprint author), SANDIA NATL LABS,DIV ELECTR PROPERTIES MAT,ALBUQUERQUE,NM 87185, USA. RI Kanicki, Jerzy/E-2753-2016 OI Kanicki, Jerzy/0000-0002-3649-8360 NR 29 TC 7 Z9 7 U1 0 U2 1 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD MAY 27 PY 1991 VL 58 IS 21 BP 2417 EP 2419 DI 10.1063/1.104889 PG 3 WC Physics, Applied SC Physics GA FM820 UT WOS:A1991FM82000033 ER PT J AU DENSLOW, ND ANDERS, JC OBRIEN, TW AF DENSLOW, ND ANDERS, JC OBRIEN, TW TI BOVINE MITOCHONDRIAL RIBOSOMES POSSESS A HIGH-AFFINITY BINDING-SITE FOR GUANINE-NUCLEOTIDES SO JOURNAL OF BIOLOGICAL CHEMISTRY LA English DT Article ID INITIAL CHARACTERIZATION; MAMMALIAN MITOCHONDRIA; LIVER-MITOCHONDRIA; ELONGATION-FACTORS; ESCHERICHIA-COLI; MESSENGER-RNA; PROTEIN; IDENTIFICATION; TRANSLOCATION; COMPLEX AB Mammalian mitochondrial ribosomes possess a binding site for guanine nucleotides. GTP binds in unit stoichiometry and with high affinity (K(d) = 15.3 +/- 2.8 nM) to the small subunit of bovine mitochondrial ribosomes. This binding activity survives high salt washes, indicating that the nucleotide binds to an integral site within this subunit. GDP also binds to the small subunit with high affinity (K(d) = 17 +/- 5.8 nm) and in unit stoichiometry. The GTP binding activity can be competed with GDP but not appreciably by other nucleotides, indicating that both GTP and GDP bind specifically and to the same site. The non-hydrolyzable analogs of GTP, guanylyl-5'-imidophosphate, and guanylyl-(beta-gamma-methylene)-diphosphonate also bind to the small subunit, but with reduced affinity. These results indicate that mammalian mitochondrial ribosomes, unlike other ribosomes, are able to interact directly with guanosine triphosphate, suggesting that the bound GTP may be involved in a novel regulatory mechanism in mitochondrial protein synthesis. C1 WALTER REED ARMY MED CTR,DEPT IMMUNOL,WASHINGTON,DC 20307. RP DENSLOW, ND (reprint author), UNIV FLORIDA,J HILLIS MILLER HLTH CTR,COLL MED,DEPT BIOCHEM & MOLEC BIOL,BOX J-245,GAINESVILLE,FL 32610, USA. FU NIGMS NIH HHS [GM-15438] NR 26 TC 31 Z9 32 U1 0 U2 0 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0021-9258 J9 J BIOL CHEM JI J. Biol. Chem. PD MAY 25 PY 1991 VL 266 IS 15 BP 9586 EP 9590 PG 5 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA FM459 UT WOS:A1991FM45900040 PM 2033053 ER PT J AU MEIN, CE FLYNN, HW AF MEIN, CE FLYNN, HW TI RECOGNITION AND REMOVAL OF THE POSTERIOR CORTICAL VITREOUS DURING VITREORETINAL SURGERY FOR IMPENDING MACULAR HOLE SO AMERICAN JOURNAL OF OPHTHALMOLOGY LA English DT Article AB Vitreoretinal surgery for impending macular hole includes recognition and removal of the posterior cortical vitreous. Previously described surgical techniques for removal of cortical vitreous used either rigid instruments (a tapered extrusion needle or a barbed microvitreoretinal blade) or a short fenestrated soft-tipped suction needle. We used a technique with the cannulated extrusion needle that detects the presence of the posterior cortical vitreous and facilitates safe removal of this layer from the retina. Although this technique is most useful when performing vitrectomy for impending macular hole, it may also be used during vitrectomy for other conditions with uncertain detachment of the posterior cortical vitreous. C1 UNIV MIAMI,SCH MED,BASCOM PALMER EYE INST,DEPT OPHTHALMOL,POB 016880,MIAMI,FL 33101. BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234. NR 5 TC 31 Z9 31 U1 0 U2 0 PU OPHTHALMIC PUBL CO PI CHICAGO PA 77 WEST WACKER DR, STE 660, CHICAGO, IL 60601 SN 0002-9394 J9 AM J OPHTHALMOL JI Am. J. Ophthalmol. PD MAY 15 PY 1991 VL 111 IS 5 BP 611 EP 613 PG 3 WC Ophthalmology SC Ophthalmology GA FK067 UT WOS:A1991FK06700013 PM 2021171 ER PT J AU SMALL, GW CARPENTER, SE KALTENBACH, TF KROUTIL, RT AF SMALL, GW CARPENTER, SE KALTENBACH, TF KROUTIL, RT TI DISCRIMINANT-ANALYSIS TECHNIQUES FOR THE IDENTIFICATION OF ATMOSPHERIC POLLUTANTS FROM PASSIVE FOURIER-TRANSFORM INFRARED INTERFEROGRAMS SO ANALYTICA CHIMICA ACTA LA English DT Article DE INFRARED SPECTROMETRY; DISCRIMINANT ANALYSIS TECHNIQUES; ATMOSPHERIC POLLUTANTS ID PATTERN-RECOGNITION AB Discriminant analysis techniques are developed for the detection of analyte signals directly from passive Fourier transform infrared (FT-IR) interferograms. The interferograms are preprocessed through the use of digital filters to isolate the spectral frequencies associated with a targeted analyte band. Subsequent application of the discriminant results in a yes/no decision regarding the presence of the analyte. Interferograms collected by a mobile FT-IR remote sensor are used in developing this methodology. Simplex optimization, coupled with a novel objective function, is found to produce the optimum discriminant for the prediction of the presence of the test analyte, SF6. The developed discriminant is able to detect low levels of SF6, while exhibiting a false alarm rate of less than 1%. This discriminant-based detection scheme can be implemented through the use of only a short interferogram segment, thereby decreasing the size of the interferogram that must be collected. This reduction in data collection requirements has great potential impact in the design of future FT-IR remote sensors. C1 USA,CTR CHEM RES DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010. RP SMALL, GW (reprint author), UNIV IOWA,DEPT CHEM,IOWA CITY,IA 52242, USA. NR 18 TC 15 Z9 15 U1 1 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0003-2670 J9 ANAL CHIM ACTA JI Anal. Chim. Acta PD MAY 15 PY 1991 VL 246 IS 1 BP 85 EP 102 DI 10.1016/S0003-2670(00)80667-4 PG 18 WC Chemistry, Analytical SC Chemistry GA FP098 UT WOS:A1991FP09800010 ER PT J AU WHITTEN, WB RAMSEY, JM ARNOLD, S BRONK, BV AF WHITTEN, WB RAMSEY, JM ARNOLD, S BRONK, BV TI SINGLE-MOLECULE DETECTION LIMITS IN LEVITATED MICRODROPLETS SO ANALYTICAL CHEMISTRY LA English DT Article ID LASER-INDUCED FLUORESCENCE; HYDRODYNAMICALLY FOCUSED FLOWS; ELECTRODYNAMIC BALANCE; LIGHT-SCATTERING; PARTICLES; PHYCOERYTHRIN; SPHERES; SIZE AB Laser-excited fluorescence from electrodynamically levitated microdroplets is used to detect small numbers of rhodamine-6G molecules. The small sample volume, typically a few picoliters reduces the background due to solvent and impurity Raman and fluorescence emission. With 514.5-nm excitation from an argon ion laser, as few as 12 molecules have been detected in glycerol-water droplets. Our present detection limit, due to variations in the impurity concentration in the blanks, corresponds to a signal-to-noise ratio of 3 for a single molecule of rhodamine-6G contained in a 1-pL volume (droplet diameter of congruent-to 12-mu-m). C1 POLYTECH INST NEW YORK,DEPT PHYS,BROOKLYN,NY 11201. USA,CTR CHEM RES DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010. RP WHITTEN, WB (reprint author), OAK RIDGE NATL LAB,DIV ANALYT CHEM,OAK RIDGE,TN 37831, USA. NR 28 TC 88 Z9 88 U1 0 U2 5 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0003-2700 J9 ANAL CHEM JI Anal. Chem. PD MAY 15 PY 1991 VL 63 IS 10 BP 1027 EP 1031 DI 10.1021/ac00010a019 PG 5 WC Chemistry, Analytical SC Chemistry GA FL305 UT WOS:A1991FL30500021 ER PT J AU MORENOSANCHEZ, R HOGUE, BA BRAVO, C NEWMAN, AH BASILE, AS CHIANG, PK AF MORENOSANCHEZ, R HOGUE, BA BRAVO, C NEWMAN, AH BASILE, AS CHIANG, PK TI INHIBITION OF SUBSTRATE OXIDATION IN MITOCHONDRIA BY THE PERIPHERAL-TYPE BENZODIAZEPINE RECEPTOR LIGAND AHN-086 SO BIOCHEMICAL PHARMACOLOGY LA English DT Article ID BINDING-SITES; RAT-BRAIN; SUBCELLULAR-DISTRIBUTION; H-3 RO5-4864; RO 5-4864; LOCALIZATION; DEHYDROGENASE; TRANSPORT; MEMBRANE; KIDNEY AB The effects, of the benzodiazepines RO5-4864, AHN 086, PK 11195 and clonazepam on respiration of mitochondria from heart, kidney, and liver were studied. ADP-stimulated respiration of heart mitochondria was the most sensitive to inhibition by AHN 086; clonazepam was not inhibitory. Several respiratory chain segment activities of submitochondrial particles were insensitive to AHN 086, except for NADH oxidase which was partially inhibited. However, in contrast to submitochondrial particles, the succinate-cytochrome c oxidoreductase activity in intact mitochondria was inhibited by AHN 086, suggesting an effect at the substrate transport level. Phosphate-induced, succinate-dependent swelling was also inhibited by AHN 086 it was not affected by clonazepam. Uncoupled ATP hydrolysis was partially inhibited by RO5-4864, AHN 086, and clonazepam. It is suggested that there is an unspecific inhibition of NADH oxidase and ATP hydrolysis by these benzodiazepines and a specific inhibition on oxidizable substrate transport by the peripheral-type benzodiazepine AHN 086. C1 NIH,GERONTOL RES CTR,BALTIMORE,MD 21224. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NIDDK,BETHESDA,MD 20892. RP MORENOSANCHEZ, R (reprint author), INST NACL CARDIOL,DEPT BIOQUIM,JUAN BADIANO 1 TLALPAN,MEXICO CITY 14080,DF,MEXICO. OI Moreno-Sanchez, Rafael/0000-0002-9587-7184 NR 40 TC 35 Z9 35 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0006-2952 J9 BIOCHEM PHARMACOL JI Biochem. Pharmacol. PD MAY 15 PY 1991 VL 41 IS 10 BP 1479 EP 1484 DI 10.1016/0006-2952(91)90564-L PG 6 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA FF861 UT WOS:A1991FF86100011 PM 1850277 ER PT J AU KALTER, DC GREENHOUSE, JJ ORENSTEIN, JM SCHNITTMAN, SM GENDELMAN, HE MELTZER, MS AF KALTER, DC GREENHOUSE, JJ ORENSTEIN, JM SCHNITTMAN, SM GENDELMAN, HE MELTZER, MS TI EPIDERMAL LANGERHANS CELLS ARE NOT PRINCIPAL RESERVOIRS OF VIRUS IN HIV DISEASE SO JOURNAL OF IMMUNOLOGY LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; HTLV-III/LAV INFECTION; T-CELL; LYMPHOCYTES-T; LYMPH-NODES; MONONUCLEAR PHAGOCYTES; INSITU HYBRIDIZATION; PERIPHERAL-BLOOD; PRIMARY TARGET; III INFECTION AB Several reports implicate Langerhans cells of skin as susceptible targets, reservoirs, and vectors for transmission of HIV: 1) numbers of Langerhans cells in skin of HIV-infected patients were decreased about 50% of that in control skin; 2) as many as 30% of Langerhans cells in the skin of HIV-infected patients were morphologically abnormal; 3) viral particles typical for HIV were identified in or around 2 to 5% of these cells; and 4) infectious HIV was isolated from skin biopsies of infected patients. These results were consistent with similar observations of HIV-infected macrophages in such tissues as brain, lung, and lymph node. Despite these findings, other investigators find no evidence for virus infection in the epidermis of HIV-infected patients by any of several immunohistochemical or ultrastructural criteria. To address this controversy, we obtained skin from 28 HIV-seropositive subjects at various clinical stages by full thickness biopsy or suction blister. Samples were analyzed by transmission electron microscopy for presence of HIV virions, by immunofluorescent staining for viral proteins, by in situ hybridization for HIV-specific mRNA, by polymerase chain reaction amplification of virus-specific DNA, and by direct virus isolation by coculture of epidermis onto monocyte target cells. By any of these techniques, demonstration of HIV in the epidermis of infected patients was equivocal and even then, infrequent. In contrast, viral DNA was detected from the dermis of the same skin samples (26 of 28 samples). Moreover, the number and morphology of Langerhans cells in skin of infected patients were within normal limits, regardless of stage of disease. These studies in toto suggest that a role for Langerhans cells as a principal viral reservoir or vector of transmission is highly unlikely. C1 HENRY M JACKSON FDN,ROCKVILLE,MD 20850. WALTER REED ARMY MED CTR,DIV COMMUNICABLE DIS & IMMUNOL,DEPT CELLULAR IMMUNOL,ROCKVILLE,MD 20850. NIAID,IMMUNOREGULAT LAB,BETHESDA,MD 20892. GEORGE WASHINGTON UNIV,SCH MED,DEPT PATHOL,WASHINGTON,DC 20007. NR 57 TC 56 Z9 56 U1 0 U2 0 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD MAY 15 PY 1991 VL 146 IS 10 BP 3396 EP 3404 PG 9 WC Immunology SC Immunology GA FL836 UT WOS:A1991FL83600017 PM 2026871 ER PT J AU NOSTEN, F TERKUILE, F CHONGSUPHAJAISIDDHI, T LUXEMBURGER, C WEBSTER, HK EDSTEIN, M PHAIPUN, L THEW, KL WHITE, NJ AF NOSTEN, F TERKUILE, F CHONGSUPHAJAISIDDHI, T LUXEMBURGER, C WEBSTER, HK EDSTEIN, M PHAIPUN, L THEW, KL WHITE, NJ TI MEFLOQUINE-RESISTANT FALCIPARUM-MALARIA ON THE THAI-BURMESE BORDER SO LANCET LA English DT Article ID PLASMODIUM-FALCIPARUM; CLINICAL-TRIAL; PHARMACOKINETICS; HALOFANTRINE; CHILDREN AB Mefloquine is the treatment of choice for uncomplicated multiresistant falciparum malaria, and in combination with sulphadoxine and pyrimethamine (MSP) at a single dose of 15/30/1.5 mg/kg, respectively, has been used in Thailand for the past 6 years. In 1985-86, MSP cured over 98% of 5192 patients with falciparum malaria on the Thai-Burmese border. 4 years later we studied the efficacy of MSP in 395 patients at the same location. The cure rate at 28 days was 70.8% (95% Cl 67-77.2%). The proportion of early treatment failures (in whom parasitaemia did not clear) had risen from 0.27 to 3.7% (p < 0.0001). Failure rates were 50% in children under 6 years old, 29% in the 6-15 age group, and 19% in adults (p < 0.001). Patients with early treatment failure were retreated with 25 mg/kg mefloquine, but 27% had a further recrudescence of infection within 28 days. The mean (95% Cl) serum mefloquine concentration at the time of first recrudescence was 638 (546-730) ng/ml, a value previously associated with successful treatment. Mefloquine concentrations were no lower in those with recrudescent infections than in age-matched successfully treated patients, suggesting that pharmacokinetic factors were not responsible for the high treatment-failure rate. Plasmodium falciparum has developed resistance to mefloquine rapidly, despite the addition of sulphadoxine and pyrimethamine and strict control of drug administration. The MSP combination should now be abandoned. C1 MAHIDOL UNIV,FAC TROP MED,420-6 RAJVITHI RD,BANGKOK 10400,THAILAND. UNIV AMSTERDAM,ACAD MED CTR,INFECT DIS & TROP MED UNIT,1105 AZ AMSTERDAM,NETHERLANDS. MED SAN FRONTIERES,PARIS,FRANCE. ARMED FORCES RES INST MED SCI,USA MED COMPONENT,BANGKOK,THAILAND. SHOKLO MALARIA RES UNIT,MAE SOD,THAILAND. JOHN RADCLIFFE HOSP,NUFFIELD DEPT CLIN MED,OXFORD OX3 9DU,ENGLAND. RI White, Nicholas/I-4629-2012; OI Nosten, Francois/0000-0002-7951-0745 FU Wellcome Trust NR 17 TC 204 Z9 207 U1 1 U2 4 PU LANCET LTD PI LONDON PA 42 BEDFORD SQUARE, LONDON, ENGLAND WC1B 3SL SN 0140-6736 J9 LANCET JI Lancet PD MAY 11 PY 1991 VL 337 IS 8750 BP 1140 EP 1143 DI 10.1016/0140-6736(91)92798-7 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA FL124 UT WOS:A1991FL12400015 PM 1674024 ER PT J AU LESLIE, DR BEAUDRY, WT SZAFRANIEC, LL ROHRBAUGH, DK AF LESLIE, DR BEAUDRY, WT SZAFRANIEC, LL ROHRBAUGH, DK TI MECHANISTIC IMPLICATIONS OF PYROPHOSPHATE FORMATION IN THE OXIDATION OF O,S-DIMETHYL PHOSPHORAMIDOTHIOATE SO JOURNAL OF ORGANIC CHEMISTRY LA English DT Article ID ALKYL THIOLSULFINATE ESTERS; PERACID OXIDATION; S-OXIDE; CHEMISTRY; ANHYDRIDES C1 USA,CTR CHEM RES DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010. RP LESLIE, DR (reprint author), DEF SCI & TECHNOL ORG,MAT RES LAB,POB 50,ASCOT,VIC 3032,AUSTRALIA. NR 17 TC 10 Z9 10 U1 0 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0022-3263 J9 J ORG CHEM JI J. Org. Chem. PD MAY 10 PY 1991 VL 56 IS 10 BP 3459 EP 3462 DI 10.1021/jo00010a055 PG 4 WC Chemistry, Organic SC Chemistry GA FL744 UT WOS:A1991FL74400055 ER PT J AU ROSCELLI, JD BASS, JW PANG, L AF ROSCELLI, JD BASS, JW PANG, L TI GUILLAIN-BARRE-SYNDROME AND INFLUENZA VACCINATION IN THE US-ARMY, 1980-1988 SO AMERICAN JOURNAL OF EPIDEMIOLOGY LA English DT Article DE IMMUNIZATION; INFLUENZA; POLYRADICULONEURITIS; VACCINATION; VACCINES ID UNITED-STATES AB An increased incidence of Guillain-Barre syndrome (polyradiculoneuritis) occurred in individuals who received the A/New Jersey (swine) influenza vaccine in 1976-1977. A retrospective study encompassing the years 1980-1988 was conducted to determine if the US Army's mass influenza vaccination program has been associated with an increased incidence of Guillain-Barre syndrome in active duty soldiers during the study years. No temporally related increase in Guillain-Barre syndrome was found during the study years. C1 TRIPLER ARMY MED CTR,DEPT PEDIAT,POB 330,HONOLULU,HI 96859. TRIPLER ARMY MED CTR,DEPT PREVENT MED,HONOLULU,HI 96859. NR 4 TC 58 Z9 61 U1 0 U2 1 PU AMER J EPIDEMIOLOGY PI BALTIMORE PA 624 N BROADWAY RM 225, BALTIMORE, MD 21205 SN 0002-9262 J9 AM J EPIDEMIOL JI Am. J. Epidemiol. PD MAY 1 PY 1991 VL 133 IS 9 BP 952 EP 955 PG 4 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA FM760 UT WOS:A1991FM76000011 PM 2028981 ER PT J AU BAVARO, SM AF BAVARO, SM TI OCCUPATIONAL-THERAPY AND OBSESSIVE-COMPULSIVE DISORDER SO AMERICAN JOURNAL OF OCCUPATIONAL THERAPY LA English DT Article DE MODELS, THEORETICAL; OCCUPATIONAL THERAPY SERVICES C1 USA,FITZSIMONS ARMY MED CTR,AURORA,CO. NR 8 TC 3 Z9 3 U1 1 U2 2 PU AMER OCCUPATION THERAPY ASSN PI ROCKVILLE PA 1383 PICCARD DRIVE PO BOX ROCKVILLE, MD 20850-4375 SN 0272-9490 J9 AM J OCCUP THER JI Am. J. Occup. Ther. PD MAY PY 1991 VL 45 IS 5 BP 456 EP 458 PG 3 WC Rehabilitation SC Rehabilitation GA FH399 UT WOS:A1991FH39900009 PM 2048627 ER PT J AU RYAN, JB WHEELER, JH HOPKINSON, WJ ARCIERO, RA KOLAKOWSKI, KR AF RYAN, JB WHEELER, JH HOPKINSON, WJ ARCIERO, RA KOLAKOWSKI, KR TI QUADRICEPS CONTUSIONS - WEST POINT UPDATE SO AMERICAN JOURNAL OF SPORTS MEDICINE LA English DT Article AB A 3 year study of 117 quadriceps contusions in West Point cadets was undertaken to document the effectiveness of a three-phased therapy program to return these young athletes to full activity with a normal knee range of motion and without recurrence of injury. The treatment protocol of this study was modeled after the 1973 West Point study of Jackson and Feagin with two major changes: 1) resting the injured leg in flexion (versus extension) and 2) emphasizing early flexion exercises (versus extension). Classification of contusions was based on knee range of motion at 12 to 24 hours after the injury (mild, > 90-degrees; moderate, 45-degrees to 90-degrees; severe, < 45-degrees). The average disability time was 13 days for mild, 19 days for moderate, and 21 days for severe contusions. Myositis ossificans developed in 9% of cadets and was associated with five risk factors (knee motion less than 120-degrees, injury occurring during football, previous quadriceps injury, delay in treatment greater than 3 days, and ipsilateral knee effusion). RP RYAN, JB (reprint author), US MIL ACAD,KELLER ARMY HOSPS,ORTHOPAED SERV,W POINT,NY 10996, USA. NR 0 TC 50 Z9 54 U1 1 U2 5 PU AMER ORTHOPAEDIC SOC SPORT MED PI WALTHAM PA 230 CALVARY STREET, WALTHAM, MA 02154 SN 0363-5465 J9 AM J SPORT MED JI Am. J. Sports Med. PD MAY-JUN PY 1991 VL 19 IS 3 BP 299 EP 304 DI 10.1177/036354659101900316 PG 6 WC Orthopedics; Sport Sciences SC Orthopedics; Sport Sciences GA FN986 UT WOS:A1991FN98600015 PM 1867338 ER PT J AU GUZZI, LM KUCERA, RF LILLIS, P HORNSTEIN, EH AF GUZZI, LM KUCERA, RF LILLIS, P HORNSTEIN, EH TI CASE-REPORT - HUMAN GAMMA-GLOBULIN USE IN THE TREATMENT OF SEVERE THROMBOCYTOPENIA ASSOCIATED WITH SARCOIDOSIS SO AMERICAN JOURNAL OF THE MEDICAL SCIENCES LA English DT Article DE SARCOIDOSIS; THROMBOCYTOPENIA; GAMMA-GLOBULIN ID AUTOIMMUNE HEMOLYTIC-ANEMIA; INTRAVENOUS IMMUNOGLOBULIN; GAMMA-GLOBULINS; THERAPY; IGG; CORTICOSTEROIDS; CHILDHOOD; PURPURA AB Thrombocytopenia associated with sarcoidosis is an uncommon, yet potentially lethal, complication. The traditional treatment for the thrombocytopenia has been steroid therapy followed by splenectomy if steroid therapy fails. The use of human immunoglobulin as a potential therapy in a patient afflicted with thrombocytopenia and sarcoidosis is reviewed. C1 DWIGHT D EISENHOWER ARMY MED CTR,DEPT MED,FT GORDON,GA 30905. NR 20 TC 6 Z9 6 U1 0 U2 1 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0002-9629 J9 AM J MED SCI JI Am. J. Med. Sci. PD MAY PY 1991 VL 301 IS 5 BP 331 EP 334 DI 10.1097/00000441-199105000-00008 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA FJ982 UT WOS:A1991FJ98200008 PM 1708650 ER PT J AU ANDERSON, GW ROSEBROCK, JA JOHNSON, AJ JENNINGS, GB PETERS, CJ AF ANDERSON, GW ROSEBROCK, JA JOHNSON, AJ JENNINGS, GB PETERS, CJ TI INFECTION OF INBRED RAT STRAINS WITH RIFT-VALLEY FEVER VIRUS - DEVELOPMENT OF A CONGENIC RESISTANT STRAIN AND OBSERVATIONS ON AGE-DEPENDENCE OF RESISTANCE SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID PATHOGENESIS; RVF AB A congenic rat strain (WF.LEW) was derived from the susceptible Wistar-Furth (WF) (background strain) and the resistant LEW (donor strain) inbred strains and was used to evaluate the phenotypic expression of a dominant Mendelian gene that confers resistance to fatal hepatic disease caused by the ZH501 strain of Rift Valley fever virus (RVFV). Resistance to hepatic disease developed gradually with age, with full expression at approximately 10 weeks in the WF.LEW and LEW rat strains. The ZH501 strain caused fatal hepatitis in WF rats regardless of age. However, resistance to the SA75 RVFV strain (relatively non-pathogenic for adult rats), was age- and dose-dependent in both WF and LEW rats. The resistance gene transferred to the newly derived WF.LEW congenic rat strain appears to amplify age-dependent resistance of adult rats, resulting in protection against fatal hepatic disease caused by the virulent ZH501 strain. The congenic rat strain will be a valuable asset in elucidating the mechanism of resistance to Rift Valley fever virus governed by the dominant Mendelian gene. C1 USA,MED RES INST INFECT DIS,DIV DIS ASSESSMENT,FREDERICK,MD 21702. NR 21 TC 19 Z9 20 U1 0 U2 1 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD MAY PY 1991 VL 44 IS 5 BP 475 EP 480 PG 6 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA FW270 UT WOS:A1991FW27000003 PM 2063951 ER PT J AU CHILDS, GE BOUDREAU, EF WIMONWATTRATEE, T PANG, L MILHOUS, WK AF CHILDS, GE BOUDREAU, EF WIMONWATTRATEE, T PANG, L MILHOUS, WK TI INVITRO AND CLINICAL CORRELATES OF MEFLOQUINE RESISTANCE OF PLASMODIUM-FALCIPARUM IN EASTERN THAILAND SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID DRUG SUSCEPTIBILITY; ANTI-MALARIAL; PYRIMETHAMINE; SULFADOXINE; FAILURE; ISOLATE; QUININE; CLONES AB A series of isolates of Plasmodium falciparum from eastern Thailand was collected prior to and after treatment failure with mefloquine. Patterns of drug sensitivity to standard and new antimalarials were characterized by using an in vitro assay based on the inhibition of schizont maturation. In vitro levels of mefloquine sensitivity of isolates were correlated with clinical treatment failures. In vitro parasite resistance to mefloquine is defined as an inhibitory dose-50 value greater than 20 nM. For isolates collected prior to treatment, there was no significant difference in mefloquine sensitivity patterns between subsequent successes and failures, suggesting that mefloquine treatment failures could not be predicted based on in vitro sensitivity of pretreatment isolates. A series of paired isolates were collected both prior to treatment with mefloquine and after recrudescence. Recrudescent isolates showed significant decreases in sensitivity to mefloquine, WR 194965, enpiroline, and halofantrine; no significant changes in sensitivity to amodiaquine, qinghaosu, and pyrimethamine; and an increase in sensitivity to chloroquine. C1 USA,MED COMPONENT,ARMED FORCES RES INST MED SCI,BANGKOK,THAILAND. WALTER REED ARMY MED CTR,DEPT EXPTL THERAPEUT,WASHINGTON,DC 20307. NR 26 TC 31 Z9 31 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD MAY PY 1991 VL 44 IS 5 BP 553 EP 559 PG 7 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA FW270 UT WOS:A1991FW27000013 PM 2063958 ER PT J AU GEER, DA ARNAUD, G BEITLER, A HOLCOMB, J HOMAN, J JAMES, L MARTIN, D MCWHIRT, E NAPOLI, P AF GEER, DA ARNAUD, G BEITLER, A HOLCOMB, J HOMAN, J JAMES, L MARTIN, D MCWHIRT, E NAPOLI, P TI COLONIC VOLVULUS - THE ARMY MEDICAL-CENTER EXPERIENCE 1983-1987 SO AMERICAN SURGEON LA English DT Article ID SIGMOID COLON; CECAL VOLVULUS; MORTALITY AB Colonic volvulus was first described in 1836 by von Rokitansky. The condition has been a formidable one, fraught with innumerable complications responsible for many deaths. Even with advances in surgical technology, mortalities have remained high. Often the diagnosis is delayed for hours or even days after presentation, and serious concomitant systemic diseases are often present. Treatment has been controversial, particularly the role of elective resection following successful nonoperative reduction. The Army Medical Center experience with colonic volvulus from 1983 through 1987 is reviewed. Fifty-four patients at the eight medical centers carried this diagnosis. Their presenting signs and symptoms are discussed. The Army patients are compared and contrasted with reviews presented in the surgical literature, and conclusions are made to give guidelines for diagnosis and treatment. C1 KIMBROUGH ARMY COMMUNITY HOSP,DEPT SURG,FT GEORGE G MEADE,MD. WALTER REED ARMY MED CTR,DEPT SURG,WASHINGTON,DC 20307. FITZSIMONS ARMY MED CTR,DEPT SURG,AURORA,CO 80045. WILLIAM BEAUMONT ARMY MED CTR,DEPT SURG,EL PASO,TX 79920. LETTERMAN ARMY MED CTR,DEPT SURG,SAN FRANCISCO,CA 94129. BROOKES ARMY MED CTR,DEPT SURG,SAN ANTONIO,TX. DWIGHT D EISENHOWER ARMY MED CTR,DEPT SURG,AUGUSTA,GA. MADIGAN ARMY MED CTR,DEPT SURG,TACOMA,WA 98431. TRIPLER ARMY MED CTR,DEPT SURG,HONOLULU,HI 96859. NR 32 TC 12 Z9 13 U1 0 U2 0 PU SOUTHEASTERN SURGICAL CONGRESS PI ATLANTA PA 1776 PEACHTREE RD, NW., SUITE 410N, ATLANTA, GA 30309-2352 SN 0003-1348 J9 AM SURGEON JI Am. Surg. PD MAY PY 1991 VL 57 IS 5 BP 295 EP 300 PG 6 WC Surgery SC Surgery GA FP104 UT WOS:A1991FP10400007 PM 2039127 ER PT J AU STRONG, WE AF STRONG, WE TI EPIDURAL ABSCESS ASSOCIATED WITH EPIDURAL CATHETERIZATION - A RARE EVENT - REPORT OF 2 CASES WITH MARKEDLY DELAYED PRESENTATION SO ANESTHESIOLOGY LA English DT Note DE ANESTHESIA TECHNIQUES, EPIDURAL; COMPLICATIONS, INFECTIONS; PAIN, REFLEX SYMPATHETIC DYSTROPHY; HERPES ZOSTER ID VARICELLA-ZOSTER; HERPES-ZOSTER RP STRONG, WE (reprint author), BROOKE ARMY MED CTR,DEPT SURG,ANESTHESIA & OPERAT SERV,FT SAM HOUSTON,TX 78234, USA. NR 16 TC 73 Z9 74 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0003-3022 J9 ANESTHESIOLOGY JI Anesthesiology PD MAY PY 1991 VL 74 IS 5 BP 943 EP 946 DI 10.1097/00000542-199105000-00024 PG 4 WC Anesthesiology SC Anesthesiology GA FJ905 UT WOS:A1991FJ90500024 PM 2021214 ER PT J AU TAYLOR, DN SANCHEZ, JL CANDLER, W THORNTON, S MCQUEEN, C ECHEVERRIA, P AF TAYLOR, DN SANCHEZ, JL CANDLER, W THORNTON, S MCQUEEN, C ECHEVERRIA, P TI TREATMENT OF TRAVELERS DIARRHEA - CIPROFLOXACIN PLUS LOPERAMIDE COMPARED WITH CIPROFLOXACIN ALONE - A PLACEBO-CONTROLLED, RANDOMIZED TRIAL SO ANNALS OF INTERNAL MEDICINE LA English DT Article ID ENTEROPATHOGENIC ESCHERICHIA-COLI; ADHERENCE; THERAPY AB Objective: To compare the safety and efficacy of loperamide used in combination with ciprofloxacin or ciprofloxacin alone for the treatment of travelers' diarrhea. Design: Double-blind, placebo-controlled, randomized clinical trial. Setting: United States Army hospital in Egypt. Participants: United States military personnel with travelers' diarrhea (n = 104) during a military exercise in November 1989. Persons who were noncompliant, had bloody diarrhea, or had received antidiarrheal medications before entry into the study were excluded. Interventions: All participants with travelers' diarrhea were treated with ciprofloxacin, 500 mg twice daily for 3 days. Fifty of these patients were randomly assigned to receive loperamide, a 4-mg first dose and 2 mg for every loose stool (as much as 16 mg/d), and 54 were randomly assigned to receive placebo. Measurements: Enterotoxigenic Escherichia coli was isolated from 57% of patients; Shigella and Salmonella, seen in 4% and 2% of patients, respectively, were not common. Main Results: After 24 hours, the symptoms of 82% of patients in the ciprofloxacin and loperamide group compared with 67% in the ciprofloxacin and placebo group had improved or fully recovered (odds ratio, 2.3; 95% CI, 0.8 to 6.3; P = 0.08). After 48 hours, the symptoms of 90% of both groups had improved or fully recovered. The mean number of stools for those receiving loperamide was not much lower than those who did not receive loperamide after 24 hours (1.9 +/- 0.2 [SE] compared with 2.6 +/- 0.2) or 48 hours (3.1 +/- 0.3 compared with 4.0 +/- 0.3) of treatment (P = 0.19). Conclusions: In a region where enterotoxigenic E. coli was the predominant cause of travelers' diarrhea, loperamide combined with ciprofloxacin was not better than treatment with ciprofloxacin alone. Loperamide appeared to have some benefit in the first 24 hours of treatment in patients infected with enterotoxigenic E. coli. Both regimens were safe. C1 USN,RES UNIT 3,CAIRO,EGYPT. WALTER REED ARMY MED CTR,DIV PREVENT MED,DEPT FIELD STUDIES,WASHINGTON,DC 20307. ARMED FORCES RES INST MED SCI,BANGKOK,THAILAND. RP TAYLOR, DN (reprint author), WALTER REED ARMY MED CTR,DIV COMMUN DIS & IMMUNOL,ENTER INFECT BRANCH,WASHINGTON,DC 20307, USA. NR 16 TC 91 Z9 92 U1 0 U2 0 PU AMER COLL PHYSICIANS PI PHILADELPHIA PA INDEPENDENCE MALL WEST 6TH AND RACE ST, PHILADELPHIA, PA 19106-1572 SN 0003-4819 J9 ANN INTERN MED JI Ann. Intern. Med. PD MAY 1 PY 1991 VL 114 IS 9 BP 731 EP 734 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA FJ117 UT WOS:A1991FJ11700004 PM 2012354 ER PT J AU MEAD, JR BURGER, RA YONK, LJ COOMBS, J WARREN, RP KENDE, M HUGGINS, J SIDWELL, RW AF MEAD, JR BURGER, RA YONK, LJ COOMBS, J WARREN, RP KENDE, M HUGGINS, J SIDWELL, RW TI EFFECT OF HUMAN, RECOMBINANT INTERLEUKIN-2 ON PUNTA TORO VIRUS-INFECTIONS IN C57BL/6 MICE SO ANTIVIRAL RESEARCH LA English DT Article DE PUNTA TORO VIRUS; PHLEBOVIRUS; BUNYAVIRIDAE; INTERLEUKIN-2; IMMUNE RESPONSE ID HERPES-SIMPLEX VIRUS; GENITAL-INFECTION; INVIVO; IMMUNITY; RIBAVIRIN AB The effect of human recombinant interleukin-2 (rIL-2) on Punta Toro virus (PTV) infection was investigated in C57BL/6 mice. Immunologic and viral parameters were assessed after mice were treated i.p. with rIL-2 for 5 days. Treatment of mice with 25000 and 12500 units/mouse of rIL-2 resulted in significant inhibition of the disease as indicated by increases in survival of mice as well as decreases in liver and serum virus titers. Serum glutamic oxalic acid and pyruvic acid transaminase levels were also lowered indicating reduced liver damage. Murine IL-2 production returned to normal or above-normal levels in rIL-2 treated mice. Natural killer cell activity was also moderately stimulated by rIL-2 treatment. Significant amounts of interferon were not detected in the sera of treated mice. Weight gain and survival rates were similar for both toxicity and normal controls indicating that rIL-2 treatments had no toxic effect. C1 UTAH STATE UNIV,DEPT ANIM DAIRY & VET SCI,LOGAN,UT 84322. UTAH STATE UNIV,DEPT BIOL,LOGAN,UT 84322. UTAH STATE UNIV,DEV CTR HANDICAPPED PERSONS,LOGAN,UT 84322. USA,MED RES INST INFECT DIS,FREDERICK,MD 21701. NR 24 TC 10 Z9 10 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-3542 J9 ANTIVIR RES JI Antiviral Res. PD MAY PY 1991 VL 15 IS 4 BP 331 EP 340 DI 10.1016/0166-3542(91)90014-I PG 10 WC Pharmacology & Pharmacy; Virology SC Pharmacology & Pharmacy; Virology GA FU439 UT WOS:A1991FU43900006 PM 1719936 ER PT J AU MEHM, WJ DILLARD, TA BERG, BW DOOLEY, JW RAJAGOPAL, KR AF MEHM, WJ DILLARD, TA BERG, BW DOOLEY, JW RAJAGOPAL, KR TI ACCURACY OF OXYHEMOGLOBIN SATURATION MONITORS DURING SIMULATED ALTITUDE EXPOSURE OF MEN WITH CHRONIC OBSTRUCTIVE PULMONARY-DISEASE SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Article ID PULSE OXIMETERS; AIR-TRAVEL; CLINICAL-EVALUATION AB Patients with chronic obstructive pulmonary disease (COPD) are at risk for hypoxemia during air travel. We assessed the comparative performance of oxyhemoglobin saturation (%O2Hb) monitors on these patients during hypobaric exposure. We measured %O2Hb by arterial catheter blood co-oximetry (COOX) and compared these values to those from a transmittance ear oximeter and a reusable digital pulse oximeter. Additionally, we examined the effect of oxygen supplementation (4 L/min) on %O2Hb. A total of 18 ambulatory males with severe COPD were exposed to 8,000 ft (565 mm Hg) in a hypobaric chamber. Multiple measures of %O2Hb were made with each monitor at sea level and at 8,000 ft, with and without supplemental oxygen. By COOX, %O2Hb fell at altitude to clinically significant levels, and was subsequently corrected with supplemental oxygen. Saturations measured by the transmittance ear oximeter were very close to the COOX, underestimating the true value by only 0.6% at altitude (p < 0.05), while the reusable digital pulse oximeter over-estimated %O2Hb alinearly by a mean of 3.8% at altitude. C1 ARMED FORCES INST PATHOL,DIV ALTITUDE & HYPERBAR PHYSIOL,WASHINGTON,DC 20306. WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT MED,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,DEPT MED,BETHESDA,MD 20814. NR 21 TC 17 Z9 17 U1 0 U2 1 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD MAY PY 1991 VL 62 IS 5 BP 418 EP 421 PG 4 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA FJ997 UT WOS:A1991FJ99700007 PM 2053906 ER PT J AU BERENBERG, JL AF BERENBERG, JL TI RESPONSE TO TREATMENT OF BREAST-CANCER SO BREAST CANCER RESEARCH AND TREATMENT LA English DT Article DE ADJUVANT CHEMOTHERAPY; BREAST CARCINOMA; JAPANESE; LOCALLY ADVANCED BREAST CANCER; PROGNOSTIC VARIABLES ID SURGICAL ADJUVANT BREAST; INDEPENDENT PROGNOSTIC FACTOR; DNA FLOW-CYTOMETRY; HER-2 NEU ONCOGENE; S-PHASE FRACTION; ESTROGEN-RECEPTOR; COMBINATION CHEMOTHERAPY; BOWEL PROJECT; AMERICAN-COLLEGE; EARLY RECURRENCE AB Variability in outcome of breast carcinoma among different racial groups has been identified between Japanese and Caucasians and between Caucasians and Blacks living in the United States. These differences are not fully explained by population differences of the known prognostic variables nodal involvement and tumor hormonal receptor status. Further elucidation of the differences in outcome should include a careful examination of other prognostic variables. These include tumor size, nuclear and histologic grade, and indicators of cell proliferation (labelling index and flow cytometric measures of S phase and DNA ploidy). More recent studies indicate that growth factor regulation, oncogene amplification (HER-2/neu) and expression, and cathepsin D levels may help to further identify prognostic subgroups. A review of the literature does not provide an answer to the question of whether there are population differences in response to standard treatments. Differences in drug distribution, elimination, and metabolism which could be related to genetic or dietary factors are intriguing hypotheses to explain why differences may exist. Careful, well controlled studies to answer these questions are urgently needed. C1 TRIPLER ARMY MED CTR,HEMATOL ONCOL SERV,HONOLULU,HI 96859. RP BERENBERG, JL (reprint author), CANC RES CTR HAWAII,1236 LAUHALA ST,HONOLULU,HI 96813, USA. NR 59 TC 2 Z9 2 U1 0 U2 0 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 0167-6806 J9 BREAST CANCER RES TR JI Breast Cancer Res. Treat. PD MAY PY 1991 VL 18 SU 1 BP S147 EP S155 DI 10.1007/BF02633548 PG 9 WC Oncology SC Oncology GA FM811 UT WOS:A1991FM81100031 PM 1651792 ER PT J AU HOWARD, SL WANG, JM ROCKWOOD, AL AF HOWARD, SL WANG, JM ROCKWOOD, AL TI OBSERVATION OF TRANSLATIONAL-TO-VIBRATIONAL ENERGY-TRANSFER IN CHARGE-TRANSFER REACTIONS OF CO+ WITH CO USING CROSSED-BEAM TECHNIQUES SO CANADIAN JOURNAL OF PHYSICS LA English DT Article ID MOLECULAR-BEAM; ION; COLLISIONS; EXCHANGE; EXCITATION; RESONANCE; DYNAMICS AB The crossed-beam method was used to investigate the charge-transfer reaction of CO+ (X 2-SIGMA+, v = 0) with CO (X 1-SIGMA+, v = 0). Scattering of CO+ demonstrates that several vibrational states are populated. At a collisional energy of 1.1 eV, transfer of translational energy to vibrational energy is shown to occur by changes of an even number of vibrational quanta. C1 WUHAN INST PHYS, WUHAN, PEOPLES R CHINA. PACIFIC NW LAB, RICHLAND, WA 99352 USA. RP HOWARD, SL (reprint author), USA, BALLIST RES LABS, SLCBR IB I, ABERDEEN PROVING GROUND, MD 21005 USA. NR 19 TC 0 Z9 0 U1 0 U2 0 PU NATL RESEARCH COUNCIL CANADA PI OTTAWA PA RESEARCH JOURNALS, MONTREAL RD, OTTAWA ON K1A 0R6, CANADA SN 0008-4204 J9 CAN J PHYS JI Can. J. Phys. PD MAY PY 1991 VL 69 IS 5 BP 581 EP 583 PG 3 WC Physics, Multidisciplinary SC Physics GA FV213 UT WOS:A1991FV21300007 ER PT J AU HOWARD, SL AF HOWARD, SL TI VIBRATIONAL-ENERGY TRANSFER IN SYMMETRICAL N-2 CHARGE-TRANSFER SO CANADIAN JOURNAL OF PHYSICS LA English DT Article ID FINE-STRUCTURE TRANSITIONS; DIFFERENTIAL CROSS-SECTIONS; MOLECULAR-BEAM; INTERMEDIATE ENERGIES; ION; COLLISIONS; DYNAMICS; EXCHANGE; AR; NO AB Results of the crossed-beam investigation of the symmetric charge-transfer reaction of N2+ (X 2-SIGMA-g, v = 0) with N2 (X 1-SIGMA-g, v = 0) near 10 eV collision energy showed a symmetrically resonant channel with DELTA v = 0 as well as a series of inelastically scattered channels. Upon deconvolution to remove the DELTA v = 0 contribution, the inelastic DELTA v = 1, 2, and 4 channels were readily observed. RP HOWARD, SL (reprint author), USA,BALLIST RES LABS,ABERDEEN PROVING GROUND,MD 21005, USA. NR 27 TC 2 Z9 2 U1 0 U2 2 PU NATL RESEARCH COUNCIL CANADA PI OTTAWA PA RESEARCH JOURNALS, MONTREAL RD, OTTAWA ON K1A 0R6, CANADA SN 0008-4204 J9 CAN J PHYS JI Can. J. Phys. PD MAY PY 1991 VL 69 IS 5 BP 584 EP 587 PG 4 WC Physics, Multidisciplinary SC Physics GA FV213 UT WOS:A1991FV21300008 ER PT J AU TIMMONS, JH HEIRONIMUS, JD AF TIMMONS, JH HEIRONIMUS, JD TI CEREBRAL INFARCT AFTER ANEURYSM CLIPPING - COMPLEMENTARY ROLE OF COMPUTED-TOMOGRAPHY AND FUNCTIONAL BRAIN-SCAN SO CLINICAL NUCLEAR MEDICINE LA English DT Note C1 BROOKE ARMY MED CTR,DEPT RADIOL,NUCL MED SERV,FT SAM HOUSTON,TX 78234. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0363-9762 J9 CLIN NUCL MED JI Clin. Nucl. Med. PD MAY PY 1991 VL 16 IS 5 BP 367 EP 368 DI 10.1097/00003072-199105000-00017 PG 2 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA FK844 UT WOS:A1991FK84400017 PM 2054994 ER PT J AU SHAPIRO, TA WERE, JBO DANSO, K NELSON, DJ DESJARDINS, RE PAMPLIN, CL AF SHAPIRO, TA WERE, JBO DANSO, K NELSON, DJ DESJARDINS, RE PAMPLIN, CL TI PHARMACOKINETICS AND METABOLISM OF ALLOPURINOL RIBOSIDE SO CLINICAL PHARMACOLOGY & THERAPEUTICS LA English DT Article ID XANTHINE-OXIDASE; RIBONUCLEOSIDE; OXIPURINOL; KINETICS AB There are no safe and effective oral drugs to treat leishmaniasis and Chagas' disease. The safety, pharmacokinetics, and metabolism of single and multiple oral doses of allopurinol riboside, an investigational antiparasitic agent, were evaluated in a randomized, double-blinded, placebo-controlled study in 32 healthy male volunteers, at levels up to 25 mg/kg q.i.d. for 13 doses. No significant toxicity was detected. Allopurinol riboside peaks in plasma 1.6 hours after administration, has an elimination half-life of 3 hours, and steady-state concentrations in the therapeutic range. However, in contrast to preclinical studies in dogs (plasma levels proportional to oral doses up to 200 mg/kg), we found that plasma levels were unexpectedly low and did not rise with increasing dose. Furthermore, allopurinol and oxypurinol (unanticipated metabolites) were detected at levels proportional to the dose of allopurinol riboside. We present a model that includes incomplete absorption, metabolism of residual drug by enteric flora, and absorption of bacterial metabolites to explain these findings in humans. C1 WELLCOME RES LABS,RES TRIANGLE PK,NC 27709. WALTER REED ARMY MED CTR,DIV EXPTL THERAPEUT,SILVER SPRING,MD. RP SHAPIRO, TA (reprint author), JOHNS HOPKINS UNIV,SCH MED,DIV CLIN PHARMACOL,403 HUNTERIAN,725 N WOLFE ST,BALTIMORE,MD 21205, USA. FU NCRR NIH HHS [MO 1 RR 000035-24] NR 19 TC 14 Z9 14 U1 0 U2 1 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0009-9236 J9 CLIN PHARMACOL THER JI Clin. Pharmacol. Ther. PD MAY PY 1991 VL 49 IS 5 BP 506 EP 514 PG 9 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA FP117 UT WOS:A1991FP11700004 PM 2029827 ER PT J AU SIEMINSKI, GC AF SIEMINSKI, GC TI COUCHING OUR CUTTING WITH COMPASSION SO COLLEGE COMPOSITION AND COMMUNICATION LA English DT Article RP SIEMINSKI, GC (reprint author), US MIL ACAD,ENGLISH,W POINT,NY 10996, USA. NR 4 TC 0 Z9 0 U1 0 U2 0 PU NATL COUNC TEACH ENG PI URBANA PA 1111 KENYON RD, URBANA, IL 61801 SN 0010-096X J9 COLL COMPOS COMMUN JI Coll. Compost. Commun. PD MAY PY 1991 VL 42 IS 2 BP 211 EP 217 DI 10.2307/358200 PG 7 WC Literature SC Literature GA FK679 UT WOS:A1991FK67900005 ER PT J AU FORCH, BE MIZIOLEK, AW AF FORCH, BE MIZIOLEK, AW TI LASER-BASED IGNITION OF H-2 O-2 AND D-2 O-2 PREMIXED GASES THROUGH RESONANT MULTIPHOTON EXCITATION OF H AND D ATOMS NEAR 243 NM SO COMBUSTION AND FLAME LA English DT Article ID OXYGEN-ATOM; PHOTOCHEMICAL IGNITION; OPTOGALVANIC DETECTION; HYDROGEN; FLAMES; IONIZATION RP FORCH, BE (reprint author), USA,BALLIST RES LABS,DIV INTERIOR BALLIST,IGNIT & COMBUST BRANCH,ABERDEEN PROVING GROUND,MD 21005, USA. NR 23 TC 26 Z9 28 U1 0 U2 2 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0010-2180 J9 COMBUST FLAME JI Combust. Flame PD MAY PY 1991 VL 85 IS 1-2 BP 254 EP 262 DI 10.1016/0010-2180(91)90192-E PG 9 WC Thermodynamics; Energy & Fuels; Engineering, Multidisciplinary; Engineering, Chemical; Engineering, Mechanical SC Thermodynamics; Energy & Fuels; Engineering GA FN965 UT WOS:A1991FN96500020 ER PT J AU BUEHLER, DA MERSMANN, TJ FRASER, JD SEEGAR, JKD AF BUEHLER, DA MERSMANN, TJ FRASER, JD SEEGAR, JKD TI DIFFERENCES IN DISTRIBUTION OF BREEDING, NONBREEDING, AND MIGRANT BALD EAGLES ON THE NORTHERN CHESAPEAKE BAY SO CONDOR LA English DT Article DE ABUNDANCE; BALD EAGLE; CHESAPEAKE BAY; DISTRIBUTION; HABITAT; HALIAEETUS-LEUCOCEPHALUS; MARYLAND; MIGRATION; POPULATION DYNAMICS AB We compared the distributions of resident breeding, resident nonbreeding, and northern and southern migrant Bald Eagles (Haliaeetus leucocephalus) on the northern Chesapeake Bay from 1984-1988. Breeding eagles were dispersed throughout most of the study area and were resident all year. Dispersion of Chesapeake nonbreeding eagles was similar to the dispersion of breeding birds on the northern Chesapeake in summer and winter. Chesapeake nonbreeding eagles moved throughout most of the bay, less-than-or-equal-to 5% of radiotagged eagles were off the bay during any month. Radio-tagged northern migrants arrived in late fall (xBAR = 21 December, n = 7, range = 61 days) and departed in early spring (xBAR = 27 March, n = 14, range = 43 days). In contrast to local eagles, northern migrants were concentrated almost exclusively on Aberdeen Proving Ground, Maryland. Radio-tagged southern migrants arrived throughout April-August (cBAR = 6 June, n = 11, range = 94 days) and departed from June-October (xBAR = 3 September, n = 22, range = 119 days). Southern migrants were more dispersed than the northern migrants but less dispersed than the resident eagles. Northern Chesapeake eagle abundance peaked twice annually; in winter (e.g., 261 eagles, December 1987), due to the presence of northern eagles, and in summer (e.g., 604 eagles, August 1988), due to the presence of southern birds. C1 USA,CTR CHEM RES DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010. RP BUEHLER, DA (reprint author), VIRGINIA POLYTECH INST & STATE UNIV,DEPT FISHERIES & WILDLIFE SCI,BLACKSBURG,VA 24061, USA. NR 22 TC 15 Z9 16 U1 1 U2 5 PU COOPER ORNITHOLOGICAL SOC PI LAWRENCE PA ORNITHOLOGICAL SOC NORTH AMER PO BOX 1897, LAWRENCE, KS 66044-8897 SN 0010-5422 J9 CONDOR JI Condor PD MAY PY 1991 VL 93 IS 2 BP 399 EP 408 DI 10.2307/1368956 PG 10 WC Ornithology SC Zoology GA FN966 UT WOS:A1991FN96600019 ER PT J AU SHAY, SS EGGLI, D JOHNSON, LF AF SHAY, SS EGGLI, D JOHNSON, LF TI SIMULTANEOUS ESOPHAGEAL PH MONITORING AND SCINTIGRAPHY DURING THE POSTPRANDIAL PERIOD IN PATIENTS WITH SEVERE REFLUX ESOPHAGITIS SO DIGESTIVE DISEASES AND SCIENCES LA English DT Article DE PH MONITORING; SCINTIGRAPHY; REFLUX ESOPHAGITIS ID GASTROESOPHAGEAL REFLUX; CLEARANCE; SCINTISCAN; DISEASE; ACID AB To compare reflux events detected by intraesophageal pH monitoring with that of scintigraphy, we simultaneously performed both techniques along with esophageal manometry in nine patients with severe reflux esophagitis. Two hundred eighteen reflux events were detected in the recumbent posture after a meal during a 40-min interval. Both techniques simultaneously detected only 23% of all reflux events. Scintigraphy alone detected 61% of all reflux events as opposed to 16% for pH monitoring. Of those reflux events diagnosed only by scintigraphy, more occurred while the intraesophageal pH was < 4 (ie, during an acid-clearing interval) than while the intraesophageal pH was > 4 (ie, when intragastric contents were neutralized by the meal). Most reflux events occurred during periods of stable, but low LES pressure. While reflux events diagnosed by scintigraphy significantly decreased during the second of two 20-min postprandial intervals, those by pH monitoring tended to increase. That simultaneous scintigraphy and pH monitoring agreed on less than 1/3 of all reflux events not only underscores the fact that both techniques measured different physical components of the esophageal refluxate (ie, volume vs acid concentration, respectively), but also were influenced by different physiologic events such as the ingestion of a meal, gastric emptying, and esophageal acid clearance. C1 WALTER REED ARMY MED CTR,DEPT RADIOL,NUCL MED SERV,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,DEPT MED,DIV DIGEST DIS,BETHESDA,MD 20814. RP SHAY, SS (reprint author), WALTER REED ARMY MED CTR,DEPT MED,GASTROENTEROL SERV,BOX 608,WASHINGTON,DC 20307, USA. NR 17 TC 38 Z9 38 U1 0 U2 2 PU PLENUM PUBL CORP PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 SN 0163-2116 J9 DIGEST DIS SCI JI Dig. Dis. Sci. PD MAY PY 1991 VL 36 IS 5 BP 558 EP 564 DI 10.1007/BF01297019 PG 7 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA FL221 UT WOS:A1991FL22100004 PM 2022155 ER PT J AU BLANEY, SM BALIS, FM POPLACK, DG AF BLANEY, SM BALIS, FM POPLACK, DG TI CURRENT PHARMACOLOGICAL TREATMENT APPROACHES TO CENTRAL-NERVOUS-SYSTEM LEUKEMIA SO DRUGS LA English DT Article ID DOSE CYTOSINE-ARABINOSIDE; ACUTE LYMPHOBLASTIC-LEUKEMIA; CANCER-STUDY-GROUP; CEREBROSPINAL-FLUID; MENINGEAL LEUKEMIA; INTRAVENOUS METHOTREXATE; INTRATHECAL METHOTREXATE; CLINICAL PHARMACOLOGY; LYMPHOCYTIC-LEUKEMIA; CHILDHOOD LEUKEMIA AB Significant advances in the treatment and prevention of meningeal leukaemia have been made in the past 3 decades. This progress has resulted from the development of innovative approaches to treatment as well as a better understanding of the pharmacokinetics and pharmacodynamics of the commonly used antileukaemic agents. Intrathecal therapy, via the intralumbar or intraventricular route, is a form of regional therapy that results in the delivery of very high drug concentrations to the principal target tumour site (the meninges) using a relatively small drug dose, thereby minimising both systemic drug exposure and systemic toxicity. The dosage and schedules, clinical pharmacology and toxicities of the commonly used intrathecal agents, methotrexate and cytarabine (cytosine arabinoside; Ara-C) are discussed in detail. Another approach which has been used to overcome the poor penetration of antileukaemic drugs into the CNS has been the use of high-dose systemic therapy. This strategy has been successfully applied in the treatment of meningeal leukaemia using both high-dose methotrexate and high-dose cytarabine. The clinical pharmacology, toxicities, and potential limitations of this approach are outlined. Finally, new agents that are currently undergoing clinical evaluation and future directions for research are also discussed. C1 NCI,PEDIAT BRANCH,LEUKEMIA BIOL SECT,BLDG 10,ROOM 13N240,BETHESDA,MD 20892. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 64 TC 26 Z9 27 U1 0 U2 1 PU ADIS INTERNATIONAL LTD PI AUCKLAND PA 41 CENTORIAN DR, PRIVATE BAG 65901, MAIRANGI BAY, AUCKLAND 10, NEW ZEALAND SN 0012-6667 J9 DRUGS JI Drugs PD MAY PY 1991 VL 41 IS 5 BP 702 EP 716 DI 10.2165/00003495-199141050-00003 PG 15 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA FP408 UT WOS:A1991FP40800003 PM 1712705 ER PT J AU HEWITT, AD CRAGIN, JH AF HEWITT, AD CRAGIN, JH TI ACID DIGESTION FOR SEDIMENTS, SLUDGES, SOILS, AND SOLID-WASTES - A PROPOSED ALTERNATIVE TO EPA SW846 METHOD-3050 - COMMENT SO ENVIRONMENTAL SCIENCE & TECHNOLOGY LA English DT Letter ID MICROWAVE-OVEN; ANTIMONY RP HEWITT, AD (reprint author), COLD REG RES & ENGN LAB,HANOVER,NH 03755, USA. NR 15 TC 12 Z9 12 U1 0 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0013-936X J9 ENVIRON SCI TECHNOL JI Environ. Sci. Technol. PD MAY PY 1991 VL 25 IS 5 BP 985 EP 986 DI 10.1021/es00017a025 PG 2 WC Engineering, Environmental; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA FK083 UT WOS:A1991FK08300031 ER PT J AU LI, J ZHU, JD APPIAH, A MCCUTCHAN, TF LONG, GW MILHOUS, WK HOLLINGDALE, MR AF LI, J ZHU, JD APPIAH, A MCCUTCHAN, TF LONG, GW MILHOUS, WK HOLLINGDALE, MR TI PLASMODIUM-BERGHEI - QUANTITATION OF INVITRO EFFECTS OF ANTIMALARIAL-DRUGS ON EXOERYTHROCYTIC DEVELOPMENT BY A RIBOSOMAL-RNA PROBE SO EXPERIMENTAL PARASITOLOGY LA English DT Article DE PLASMODIUM-BERGHEI; MALARIA; RIBOSOMAL-RNA PROBE; MALARIAL CHEMOTHERAPY; INVITRO DRUG ASSAY; RIBOSOMAL RNA (RIBOSOMAL-RNA); EXOERYTHROCYTIC (EE); 50-PERCENT INHIBITORY CONCENTRATION (IC50); PRIMAQUINE (PQ) PYRIMETHAMINE (PYR); CHLOROQUINE (CQ); STANDARD SALINE CITRATE (SSC) ID STAGE; POPULATIONS; CULTIVATION; SPOROZOITES; FALCIPARUM; DIAGNOSIS; CULTURE; MALARIA C1 BIOMED RES INST, ROCKVILLE, MD 20852 USA. NIAID, PARASIT DIS LAB, BETHESDA, MD 20892 USA. USN, DEPT INFECT DIS, DIV MALARIA, BETHESDA, MD 20814 USA. WALTER REED ARMY MED CTR, DEPT PARASITOL, DIV EXPTL THERAPEUT, WASHINGTON, DC 20307 USA. RP LI, J (reprint author), SECOND MIL MED UNIV, 594 XIANG YIN RD, SHANGHAI, PEOPLES R CHINA. NR 21 TC 13 Z9 13 U1 0 U2 1 PU ACADEMIC PRESS INC ELSEVIER SCIENCE PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA SN 0014-4894 EI 1090-2449 J9 EXP PARASITOL JI Exp. Parasitol. PD MAY PY 1991 VL 72 IS 4 BP 450 EP 458 DI 10.1016/0014-4894(91)90091-A PG 9 WC Parasitology SC Parasitology GA FK855 UT WOS:A1991FK85500013 PM 2026219 ER PT J AU ROGERS, KR CAO, CJ VALDES, JJ ELDEFRAWI, AT ELDEFRAWI, ME AF ROGERS, KR CAO, CJ VALDES, JJ ELDEFRAWI, AT ELDEFRAWI, ME TI ACETYLCHOLINESTERASE FIBEROPTIC BIOSENSOR FOR DETECTION OF ANTICHOLINESTERASES SO FUNDAMENTAL AND APPLIED TOXICOLOGY LA English DT Article ID ELECTRODE; ENZYME C1 UNIV MARYLAND,SCH MED,DEPT PHARMACOL & EXPTL THERAPEUT,BALTIMORE,MD 21201. USA,CTR RES DEV & ENGN,EDGEWOOD,MD 21010. FU NIEHS NIH HHS [ES 02594] NR 28 TC 76 Z9 77 U1 0 U2 8 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0272-0590 J9 FUND APPL TOXICOL JI Fundam. Appl. Toxicol. PD MAY PY 1991 VL 16 IS 4 BP 810 EP 820 DI 10.1016/0272-0590(91)90166-2 PG 11 WC Toxicology SC Toxicology GA FJ691 UT WOS:A1991FJ69100017 PM 1909249 ER PT J AU MCDONNELL, M AF MCDONNELL, M TI DIFFERENT VIEWS - DIGITAL IMAGE WARPING SO IEEE COMPUTER GRAPHICS AND APPLICATIONS LA English DT Letter RP MCDONNELL, M (reprint author), USA,ENGN TOPO LABS,WASHINGTON,DC 20310, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU IEEE COMPUTER SOC PI LOS ALAMITOS PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1264 SN 0272-1716 J9 IEEE COMPUT GRAPH JI IEEE Comput. Graph. Appl. PD MAY PY 1991 VL 11 IS 3 BP 4 EP 5 PG 2 WC Computer Science, Software Engineering SC Computer Science GA FL270 UT WOS:A1991FL27000002 ER PT J AU FOLKES, PA TAYSINGLARA, M BUCHWALD, W NEWMAN, P POLI, L AF FOLKES, PA TAYSINGLARA, M BUCHWALD, W NEWMAN, P POLI, L TI ANALYTICAL VOLTAGE DEPENDENCE OF AN UNSATURATED MESFETS GATE CAPACITANCE SO IEEE ELECTRON DEVICE LETTERS LA English DT Article ID GAAS; MODEL AB Using a one-dimensional gradual channel analysis we derive an analytical expression for the gate-source capacitance of an unsaturated MESFET as a function of the applied drain and gate voltages. Experimental measurements of the dependence of the gate-source capacitance on drain voltage show good agreement with theory when the device is biased below saturation. As the MESFET is biased into saturation the measured capacitance decreases with increasing drain voltage at a slightly faster rate than that predicted by the gradual channel theory due to high-field effects. These results show that the derived analytical expression may be useful for the analysis of the characteristics of MESFET's that are biased in the linear region. RP FOLKES, PA (reprint author), USA,ELECTR TECHNOL & DEVICES LAB,FT MONMOUTH,NJ 07703, USA. NR 10 TC 3 Z9 3 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0741-3106 J9 IEEE ELECTR DEVICE L JI IEEE Electron Device Lett. PD MAY PY 1991 VL 12 IS 5 BP 215 EP 217 DI 10.1109/55.79560 PG 3 WC Engineering, Electrical & Electronic SC Engineering GA FJ400 UT WOS:A1991FJ40000008 ER PT J AU SMITH, RE MOLTER, LA DUTTA, M AF SMITH, RE MOLTER, LA DUTTA, M TI EVALUATION OF REFRACTIVE-INDEX APPROXIMATIONS USED FOR MODE DETERMINATION IN MULTIPLE QUANTUM-WELL SLAB WAVE-GUIDES SO IEEE JOURNAL OF QUANTUM ELECTRONICS LA English DT Letter AB Approximations commonly used to determine the effective indexes of the guided modes of optical waveguides formed using multiple quantum well materials are compared to the exact solutions in the slab waveguide model. Modeling the quantum well region as a single homogeneous layer with an average index of refraction is shown to produce results in close agreement with exact values of the effective index. A geometrically weighted average of the indexes provides the most accurate approximation for typical values of index and layer thickness of GaAs-Al(x)Ga(1-x)As quantum well waveguides. C1 USA,ELECT TECHNOL & DEVICES LAB,FT MONMOUTH,NJ 07703. RP SMITH, RE (reprint author), SWARTHMORE COLL,DEPT ENGN,SWARTHMORE,PA 19081, USA. NR 5 TC 14 Z9 14 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9197 J9 IEEE J QUANTUM ELECT JI IEEE J. Quantum Electron. PD MAY PY 1991 VL 27 IS 5 BP 1119 EP 1122 DI 10.1109/3.83363 PG 4 WC Engineering, Electrical & Electronic; Optics; Physics, Applied SC Engineering; Optics; Physics GA FW125 UT WOS:A1991FW12500003 ER PT J AU KUSTERS, JA VIG, JR AF KUSTERS, JA VIG, JR TI HYSTERESIS IN QUARTZ RESONATORS - A REVIEW SO IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL LA English DT Review ID PHASE AB The frequency versus temperature and pressure versus temperature characteristics of quartz crystal resonators do not repeat exactly upon temperature cycling, i.e., resonators exhibit "hysteresis." The subject of hysteresis is reviewed. The subject has been studied only sporadically until recently. A search of the literature has revealed only about a dozen papers in the Proceedings of the Annual Symposium on Frequency Control, a couple of contract reports, and a few other papers that deal with the subject. Books dealing with oscillators either do not mention the subject at all, or devote only a few sentences to the phenomenon. The causes of hysteresis are not well understood. The evidence to date is inconclusive. The mechanisms that can cause hysteresis include: strain changes, changes in the quartz, contamination redistribution, oscillator circuitry hysteresis, and apparent hysteresis due to thermal gradients. C1 USA,LABCOM,ELECTR TECHNOL & DEVICES LAB,FT MONMOUTH,NJ 07703. RP KUSTERS, JA (reprint author), HEWLETT PACKARD CO,SANTA CLARA DIV,5301 STEVENS CREEK BLVD,SANTA CLARA,CA 95052, USA. OI Vig, John/0000-0002-2378-0113 NR 54 TC 12 Z9 12 U1 0 U2 4 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0885-3010 J9 IEEE T ULTRASON FERR JI IEEE Trans. Ultrason. Ferroelectr. Freq. Control PD MAY PY 1991 VL 38 IS 3 BP 281 EP 290 DI 10.1109/58.79613 PG 10 WC Acoustics; Engineering, Electrical & Electronic SC Acoustics; Engineering GA FJ072 UT WOS:A1991FJ07200016 PM 18267585 ER PT J AU VIG, JR AF VIG, JR TI ON ACOUSTIC SENSOR SENSITIVITY SO IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL LA English DT Letter AB Acoustic sensor sensitivity expressed as frequency change per unit of measured can result in the erroneous conclusion that higher frequency sensors are superior to lower frequency ones. It is argued that, when compared on the bases of reproducibility and resolution capability, "good" low frequency sensors are superior to "good" high frequency ones. RP VIG, JR (reprint author), USA,SLCET EQ,ELECTR TECHNOL & DEVICES LAB,FT MONMOUTH,NJ 07703, USA. OI Vig, John/0000-0002-2378-0113 NR 4 TC 7 Z9 7 U1 1 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0885-3010 J9 IEEE T ULTRASON FERR JI IEEE Trans. Ultrason. Ferroelectr. Freq. Control PD MAY PY 1991 VL 38 IS 3 BP 311 EP 311 DI 10.1109/58.79617 PG 1 WC Acoustics; Engineering, Electrical & Electronic SC Acoustics; Engineering GA FJ072 UT WOS:A1991FJ07200020 PM 18267589 ER PT J AU TESSLER, A SAETHER, E AF TESSLER, A SAETHER, E TI A COMPUTATIONALLY VIABLE HIGHER-ORDER THEORY FOR LAMINATED COMPOSITE PLATES SO INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN ENGINEERING LA English DT Article ID MIXED VARIATIONAL THEOREM; TRANSVERSE-SHEAR; REFINED THEORY AB A variational higher-order theory involving all transverse strain and stress components is proposed for the analysis of laminated composite plates. Derived from three-dimensional elasticity with emphasis on developing a viable computational methodology, the theory is well suited for finite element approximations as it incorporates both C0 and C-1 continuous kinematic fields and Poisson boundary conditions. From the theory, a simple three-node stretching-bending finite element is developed and applied to the problem of cylindrical bending of a symmetric carbon/epoxy laminate for which an exact solution is available. Both the analytic and finite element results were found to be in excellent agreement with the exact solution for a wide range of the length-to-thickness ratio. The proposed higher-order theory has the same computational advantages as first-order shear-deformable theories. The present methodology, however, provides greater predictive capabilities, especially, for thick-section composites. RP TESSLER, A (reprint author), USA,MECH & STRUCT BRANCH,MAT TECHNOL LAB,WATERTOWN,MA 02172, USA. RI Tessler, Alexander/A-4729-2009 NR 30 TC 27 Z9 28 U1 0 U2 2 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0029-5981 J9 INT J NUMER METH ENG JI Int. J. Numer. Methods Eng. PD MAY PY 1991 VL 31 IS 6 BP 1069 EP 1086 DI 10.1002/nme.1620310604 PG 18 WC Engineering, Multidisciplinary; Mathematics, Interdisciplinary Applications SC Engineering; Mathematics GA FK372 UT WOS:A1991FK37200003 ER PT J AU HO, VB KRANSDORF, MJ JELINEK, JS KIM, CK AF HO, VB KRANSDORF, MJ JELINEK, JS KIM, CK TI DORSAL DEFECT OF THE PATELLA - MR FEATURES SO JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY LA English DT Article DE PATELLA; KNEE, ABNORMALITIES; MAGNETIC RESONANCE IMAGING; COMPUTED TOMOGRAPHY AB Dorsal defect of the patella (DDP) is a benign lesion with characteristic radiologic features. We describe the MR appearance of a typical DDP and a healed DDP as seen in two patients. The classic CT appearance is also described. C1 ARMED FORCES INST PATHOL,DEPT RADIOL PATHOL,WASHINGTON,DC 20306. WALTER REED ARMY MED CTR,DEPT RADIOL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT ORTHOPED,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,DEPT RADIOL & NUCL MED,BETHESDA,MD 20814. NR 7 TC 14 Z9 14 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0363-8715 J9 J COMPUT ASSIST TOMO JI J. Comput. Assist. Tomogr. PD MAY-JUN PY 1991 VL 15 IS 3 BP 474 EP 476 DI 10.1097/00004728-199105000-00025 PG 3 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA FM318 UT WOS:A1991FM31800024 PM 2026814 ER PT J AU BAUMGARTNER, JC FALKLER, WA AF BAUMGARTNER, JC FALKLER, WA TI REACTIVITY OF IGG FROM EXPLANT CULTURES OF PERIAPICAL LESIONS WITH IMPLICATED MICROORGANISMS SO JOURNAL OF ENDODONTICS LA English DT Article ID BLACK-PIGMENTED BACTEROIDES; LINKED IMMUNOSORBENT-ASSAY; ROOT-CANAL INFECTIONS; APICAL PERIODONTITIS; ENDODONTALIS AB The presence of IgG in periapical inflammatory lesions suggests that immune responses participate in the disease process. The purpose of this investigation was to study the reactivity of IgG from the supernatant fluids of explant cultures of periapical lesions with microorganisms implicated in infections of endodontic origin. Ninety periapical lesions that had been contiguous with the apex of a root were removed and maintained in explant cultures. A dotenzyme-linked immunosorbent assay (dot-ELISA) was used to demonstate the presence of IgG in the supernatant fluids of the explant cultures reactive with a panel of microorganisms associated with infections of endodontic origin. The percentages of reactivity by dot-ELISA follow: Bacteroides intermedius (84%), B. buccae (12%), Porphyromonas (Bacteroides) gingivalis (50%), P. endodontalis (58%), P. asaccharolyticus (17%), Peptostreptococcus micros (44%), P. anaerobius (26%), Eubacterium alactolyticum (34%), Fusobacterium nucleatum (14%), and Actinomyces israelii (6%). At least one of the three species of B. intermedius, P. gingivalis, or P. endodontalis tested gave a positive dot-ELISA with 89% of the supernatant fluids from explant cultures of periapical lesions. A lack of cross reactivity of IgG in supernatant fluids from explants of periapical lesions was demonstrated for the four strains of black-pigmented Bacteroides/Porphyromonas by dot-ELISA. C1 WALTER REED ARMY MED CTR,INST DENT RES,MICROBIOL BRANCH,WASHINGTON,DC 20307. UNIV MARYLAND,SCH DENT,DEPT MICROBIOL,COLLEGE PK,MD 20742. NR 19 TC 11 Z9 11 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0099-2399 J9 J ENDODONT JI J. Endod. PD MAY PY 1991 VL 17 IS 5 BP 207 EP 212 PG 6 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA FK200 UT WOS:A1991FK20000001 PM 1940739 ER PT J AU SHIELDS, FD THACKSTON, EL AF SHIELDS, FD THACKSTON, EL TI DESIGNING TREATMENT BASIN DIMENSIONS TO REDUCE COST SO JOURNAL OF ENVIRONMENTAL ENGINEERING-ASCE LA English DT Note C1 USA,WATERWAYS EXPT STN,VICKSBURG,MS 39180. VANDERBILT UNIV,DEPT CIVIL & ENVIRONM ENGN,NASHVILLE,TN 37240. RP SHIELDS, FD (reprint author), USDA ARS,NATL SEDIMENTAT LAB,BOX 1157,OXFORD,MS 38655, USA. NR 2 TC 3 Z9 3 U1 1 U2 1 PU ASCE-AMER SOC CIVIL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-9372 J9 J ENVIRON ENG-ASCE JI J. Environ. Eng.-ASCE PD MAY-JUN PY 1991 VL 117 IS 3 BP 381 EP 386 DI 10.1061/(ASCE)0733-9372(1991)117:3(381) PG 6 WC Engineering, Environmental; Engineering, Civil; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA FN173 UT WOS:A1991FN17300009 ER PT J AU TRANT, CM AF TRANT, CM TI DESCRIPTION OF THE ABRASION FURROW IN HANGING SO JOURNAL OF FORENSIC SCIENCES LA English DT Letter RP TRANT, CM (reprint author), TRIPLER ARMY MED CTR,HONOLULU,HI 96859, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC TESTING MATERIALS PI W CONSHOHOCKEN PA 100 BARR HARBOR DR, W CONSHOHOCKEN, PA 19428-2959 SN 0022-1198 J9 J FORENSIC SCI JI J. Forensic Sci. PD MAY PY 1991 VL 36 IS 3 BP 634 EP 634 PG 1 WC Medicine, Legal SC Legal Medicine GA FP610 UT WOS:A1991FP61000008 PM 1856633 ER PT J AU SELAVKA, CM AF SELAVKA, CM TI POPPY SEED INGESTION AS A CONTRIBUTING FACTOR TO OPIATE-POSITIVE URINALYSIS RESULTS - THE PACIFIC PERSPECTIVE SO JOURNAL OF FORENSIC SCIENCES LA English DT Article; Proceedings Paper CT 42ND ANNUAL MEETING OF THE AMERICAN ACADEMY OF FORENSIC SCIENCES CY FEB 19-24, 1990 CL CINCINNATI, OH SP AMER ACAD FORENS SCI DE TOXICOLOGY; OPIATES; POPPY SEEDS; MORPHINE; CODEINE; UNKNOWING INGESTION; DRUG TESTING ID MORPHINE; CODEINE; CONSUMPTION; URINE AB The possible contribution of poppy seed foods to positive opiate urinalysis results, especially from foods available in the Pacific Rim area, has recently become an issue for the U.S. Army Forensic Toxicology Drug Testing Laboratory in Hawaii. To assess the likelihood of this possible contribution, seven different poppy seed food products were consumed by male and female volunteers, and urine specimens were collected at time increments up to either 24 or 72 h. Specimens were evaluated for opiates using Roache Abuscreen radioimmunoassay (RIA), and all RIA positive specimens were analyzed for morphine and codeine using gas chromatography/mass spectrometry (GC-MS). Poppy seed cake, bagels, muffins, and rolls did not contain sufficient quantities of poppy seeds to give rise to opiate positive specimens by U.S. Department of Defense (DOD) GC-MS cutoff levels (morphine = 4000 ng/mL, codeine = 2000 ng/mL), although a number of specimens were positive by National Institute on Drug Abuse (NIDA) cutoff levels (morphine and codeine = 300 ng/mL). However, ingestion of poppy seed streusel or Danish pastry led to confirmed morphine and codeine positive specimens, irrespective of the use of DOD or NIDA confirmation cutoff values. In addition, significant amounts of codeine were observed in a number of these specimens. These findings argue against the unqualified application of previously published quantitative guidelines for eliminating poppy seed ingestion as a possible cause for a positive opiate urinalysis result. RP SELAVKA, CM (reprint author), TRIPLER ARMY MED CTR,FORENS TOXICOL DRUG TESTING LAB,HONOLULU,HI 96859, USA. NR 9 TC 41 Z9 42 U1 0 U2 1 PU AMER SOC TESTING MATERIALS PI W CONSHOHOCKEN PA 100 BARR HARBOR DR, W CONSHOHOCKEN, PA 19428-2959 SN 0022-1198 J9 J FORENSIC SCI JI J. Forensic Sci. PD MAY PY 1991 VL 36 IS 3 BP 685 EP 696 PG 12 WC Medicine, Legal SC Legal Medicine GA FP610 UT WOS:A1991FP61000014 PM 1856638 ER PT J AU HORTON, RA NELSON, LK AF HORTON, RA NELSON, LK TI AN EVALUATION OF THE USE OF LASER-INDUCED INFRARED LUMINESCENCE TO DIFFERENTIATE WRITING INKS SO JOURNAL OF FORENSIC SCIENCES LA English DT Article; Proceedings Paper CT 42ND ANNUAL MEETING OF THE AMERICAN ACADEMY OF FORENSIC SCIENCES CY FEB 19-24, 1990 CL CINCINNATI, OH SP AMER ACAD FORENS SCI DE QUESTIONED DOCUMENTS; INKS; LUMINESCENCE; INK DIFFERENTIATION AB An examination of 56 inks with an argon-ion laser revealed the laser will sometimes stimulate infrared luminescence in inks which did not produce infrared luminescence under the video spectral comparator (VSC-1). This infrared luminescence was always at a higher range (usually 830 to 900 nm) than that found under the VSC-1. This indicates that laser-induced infrared luminescence may be a useful tool in differentiating between inks which otherwise appear similar. RP HORTON, RA (reprint author), USA,CRIME LAB,CONUS,FT GILLEM,GA 30050, USA. NR 5 TC 6 Z9 6 U1 0 U2 1 PU AMER SOC TESTING MATERIALS PI W CONSHOHOCKEN PA 100 BARR HARBOR DR, W CONSHOHOCKEN, PA 19428-2959 SN 0022-1198 J9 J FORENSIC SCI JI J. Forensic Sci. PD MAY PY 1991 VL 36 IS 3 BP 838 EP 843 PG 6 WC Medicine, Legal SC Legal Medicine GA FP610 UT WOS:A1991FP61000030 ER PT J AU GARBRECHT, J BRUNNER, G AF GARBRECHT, J BRUNNER, G TI HYDROLOGIC CHANNEL-FLOW ROUTING FOR COMPOUND SECTIONS SO JOURNAL OF HYDRAULIC ENGINEERING-ASCE LA English DT Article ID ACCURACY CRITERIA; PARAMETERS AB An efficient channel-flow routing scheme for large drainage networks with compound sections and for continuous long-term simulation is often needed for sediment and water-quality investigations. A Muskingum-Cunge channel-flow routing scheme is adopted for this purpose. Main channel and overbank flow in compound cross sections are decoupled and routed separately to quantify the different flow characteristics in each channel portion. A variable time step is introduced to increase the efficiency of the numerical scheme. The adaptations of the channel-flow routing scheme are tested against hydraulic channel-flow routing using the DAMBRK model. Test conditions consist of several hypothetical flood hydrographs in long prismatic channels with significant overbank storage. For the tested cases, hydrograph peak and time to peak are, on the average, within 4% of the results from hydraulic routing. Simulated hydrograph shapes are consistent with expectations, and hydrograph distortions, resulting from overbank flood plains, are well reproduced. Furthermore, execution time of the numerical scheme is generally more than one order of magnitude faster than the benchmark hydraulic routing. C1 USA,CORPS ENGINEERS,CTR HYDRO ENGN,ST DAVIS,CA 95616. RP GARBRECHT, J (reprint author), USDA,ARS,WATER QUAL & WATERSHED RES LAB,POB 1430,DURANT,OK 74702, USA. NR 27 TC 15 Z9 15 U1 0 U2 0 PU ASCE-AMER SOC CIVIL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-9429 J9 J HYDRAUL ENG-ASCE JI J. Hydraul. Eng.-ASCE PD MAY PY 1991 VL 117 IS 5 BP 629 EP 642 DI 10.1061/(ASCE)0733-9429(1991)117:5(629) PG 14 WC Engineering, Civil; Engineering, Mechanical; Water Resources SC Engineering; Water Resources GA FH667 UT WOS:A1991FH66700006 ER PT J AU HIRSCH, VM ZACK, PM VOGEL, AP JOHNSON, PR AF HIRSCH, VM ZACK, PM VOGEL, AP JOHNSON, PR TI SIMIAN IMMUNODEFICIENCY VIRUS-INFECTION OF MACAQUES - END-STAGE DISEASE IS CHARACTERIZED BY WIDESPREAD DISTRIBUTION OF PROVIRAL DNA IN TISSUES SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID T-CELL; PERIPHERAL-BLOOD; III INFECTION; HTLV-III/LAV; ANEMIA VIRUS; LYMPH-NODES; AIDS; RETROVIRUS; LENTIVIRUS; MONKEYS AB Four simian immunodeficiency virus (SIV)-infected macaques in the terminal stages of AIDS were studied. Easily detectable unintegrated proviral DNA was present in nearly every tissue (lymphoid and nonlymphoid) examined. SIV-specific immunohistochemistry revealed that macrophages or macrophage-like cells were the predominant reservoirs for SIV. High burdens of infectious SIV were also characteristic of end-stage disease. At the molecular level, sequence analyses of molecular clones derived directly from tissue demonstrated that SIV, like other RNA viruses, exists as a mixture of closely related genomes. Viruses derived by cocultivation seemed to be selected for their ability to grow in tissue culture and did not represent the wide spectrum of genotypes in tissues. These data indicate that SIV-induced immunodeficiency is a complex, multisystem disease and that SIV replication, in addition to impairing the immune system, may have direct deleterious effects on multiple organ systems. C1 GEORGETOWN UNIV,DEPT MICROBIOL,DIV MOLEC VIROL & IMMUNOL,RETROVIRAL PATHOGENESIS SECT,WASHINGTON,DC 20007. USA,MED RES INST INFECT DIS,DIV PATHOL,FREDERICK,MD 21701. RP HIRSCH, VM (reprint author), NIAID,INFECT DIS LAB,TWINBROOK 2,12441 PARKLAWN DR,ROCKVILLE,MD 20852, USA. RI Johnson, Philip/A-6892-2009 FU NIAID NIH HHS [AI-72623] NR 42 TC 84 Z9 84 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD MAY PY 1991 VL 163 IS 5 BP 976 EP 988 PG 13 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA FH745 UT WOS:A1991FH74500007 PM 2019773 ER PT J AU CRYZ, SJ CROSS, AS SADOFF, JC WEGMANN, A QUE, JU FURER, E AF CRYZ, SJ CROSS, AS SADOFF, JC WEGMANN, A QUE, JU FURER, E TI SAFETY AND IMMUNOGENICITY OF ESCHERICHIA-COLI O-18 O-SPECIFIC POLYSACCHARIDE (O-PS)-TOXIN-A AND O-PS-CHOLERA TOXIN CONJUGATE VACCINES IN HUMANS SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID PSEUDOMONAS-AERUGINOSA; LIPOPOLYSACCHARIDE; BACTEREMIA; ANTIBODIES; INFECTION; KLEBSIELLA; MORTALITY; ANTIGENS; K1 AB O-specific polysaccharide (O-PS) isolated from serotype 18 Escherichia coli lipopolysaccharide (LPS) was covalently coupled to either Pseudomonas aeruginosa toxin A (TA) or cholera toxin (CT). The conjugates were nontoxic and nonpyrogenic. The conjugates were well tolerated on parenteral administration to human volunteers, with only mild, transient local reactions reported. Immunization engendered an IgG antibody response to both the O-PS and carrier protein. Anti-LPS antibody promoted the uptake and killing of an E. coli O18 strain bearing the K1 capsule by human polymorphonuclear leukocytes, which was complement dependent. Antibody to carrier protein neutralized the activity of native TA or CT in cell culture assays. Passively transferred IgG isolated from the serum of immunized donors provided a significant (P < .01) degree of protection against fatal experimental E. coli O18 sepsis in mice. This study illustrates the potential use of such conjugates as vaccines against E. coli extraintestinal infections. C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. RP CRYZ, SJ (reprint author), SWISS SERUM & VACCINE INST,POB 2707,CH-3001 BERN,SWITZERLAND. NR 32 TC 13 Z9 13 U1 0 U2 2 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD MAY PY 1991 VL 163 IS 5 BP 1040 EP 1045 PG 6 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA FH745 UT WOS:A1991FH74500016 PM 1708398 ER PT J AU CRYZ, SJ FURER, E SADOFF, JC FREDEKING, T QUE, JU CROSS, AS AF CRYZ, SJ FURER, E SADOFF, JC FREDEKING, T QUE, JU CROSS, AS TI PRODUCTION AND CHARACTERIZATION OF A HUMAN HYPERIMMUNE INTRAVENOUS IMMUNOGLOBULIN AGAINST PSEUDOMONAS-AERUGINOSA AND KLEBSIELLA SPECIES SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID TRANSFERABLE ENZYMATIC RESISTANCE; GRAM-NEGATIVE BACTEREMIA; CARE UNIT PATIENTS; NOSOCOMIAL INFECTIONS; BACTERIAL-INFECTIONS; ESCHERICHIA-COLI; CEPHALOSPORINS; IMMUNOGENICITY; PNEUMONIAE; HOSPITALS AB A hyperimmune globulin for intravenous use (H-IVIG) was prepared from the plasma of donors immunized with Pseudomonas aeruginosa and Klebsiella vaccines. H-IVIG preparations contained substantially higher IgG antibody levels to all nine P. aeruginosa vaccine antigens and to 22 of the 24 Klebsiella vaccine antigens than did commercial IVIG. The H-IVIG was more effective at promoting the opsonophagocytic killing of P. aeruginosa and Klebsiella vaccine serotype strains than normal IVIG. The H-IVIG neutralized > 20 times more toxin A than commercial IVIG. Only the H-IVIG offered significant protection against Klebsiella K2 sepsis. The H-IVIG provided significantly better protection against six of the eight P. aeruginosa vaccine serotypes than normal IVIG when compared in a murine burn wound sepsis model. The H-IVIG also protected mice against an Enterobacter aerogenes challenge, whereas normal IVIG was ineffective. C1 WALTER REED ARMY MED CTR, WASHINGTON, DC 20307 USA. ANTIBODY SYST LTD, BEDFORD, TX USA. RP CRYZ, SJ (reprint author), SWISS SERUM & VACCINE INST, POB 2707, CH-3001 BERN, SWITZERLAND. NR 37 TC 30 Z9 31 U1 0 U2 0 PU OXFORD UNIV PRESS INC PI CARY PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA SN 0022-1899 EI 1537-6613 J9 J INFECT DIS JI J. Infect. Dis. PD MAY PY 1991 VL 163 IS 5 BP 1055 EP 1061 PG 7 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA FH745 UT WOS:A1991FH74500018 PM 1902245 ER PT J AU TAYLOR, DN KIEHLBAUCH, JA TEE, W PITARANGSI, C ECHEVERRIA, P AF TAYLOR, DN KIEHLBAUCH, JA TEE, W PITARANGSI, C ECHEVERRIA, P TI ISOLATION OF GROUP-2 AEROTOLERANT CAMPYLOBACTER SPECIES FROM THAI CHILDREN WITH DIARRHEA SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID JEJUNI INFECTION; HUMAN-SERUM; FEATURES; COLI; DISEASE; SALMONELLA; FILTRATION; ENTERITIS; SHIGELLA; STRAINS AB Campylobacter species were isolated from 93 (15%) of 631 Thai children with diarrhea using the membrane filter technique on nonselective blood agar incubated at 37-degrees-C. Campylobacter jejuni was isolated from 62 (10%), Campylobacter coli from 14 (2%), and atypical campylobacters from 17 (3%). The 17 atypical strains were first characterized biochemically and by dot blot DNA hybridization. Catalase-negative strains also were characterized by DNA hybridization and ribotype pattern. One strain was a catalase-negative "Campylobacter upsaliensis" and another was a nitrate-negative Campylobacter jejuni doylei. Fifteen isolates were aerotolerant strains most closely resembling Campylobacter cryaerophila or "C. upsaliensis" by dot hybridization. These aerotolerant strains, designated group 2 ("Campylobacter butzleri"), had ribotypes distinct from C. cryaerophila and have previously been shown to be related by DNA hybridization at the species level to the group 2 aerotolerant Campylobacter type strain (D2686). Group 2 aerotolerant Campylobacter were the atypical Campylobacter species most frequently isolated from Thai children with diarrhea. C1 WALTER REED ARMY MED CTR,DEPT BACTERIAL DIS,WASHINGTON,DC 20307. CTR DIS CONTROL,CTR INFECT DIS,ENTER DIS LAB,ATLANTA,GA 30333. FAIRFIELD HOSP,VICTORIA,AUSTRALIA. ARMED FORCES RES INST MED SCI,DEPT BACTERIOL,BANGKOK,THAILAND. NR 29 TC 78 Z9 78 U1 0 U2 1 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD MAY PY 1991 VL 163 IS 5 BP 1062 EP 1067 PG 6 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA FH745 UT WOS:A1991FH74500019 PM 2019754 ER PT J AU BROWN, AE DANCE, DAB SUPUTTAMONGKOL, Y CHAOWAGUL, W KONGCHAREON, S WEBSTER, HK WHITE, NJ AF BROWN, AE DANCE, DAB SUPUTTAMONGKOL, Y CHAOWAGUL, W KONGCHAREON, S WEBSTER, HK WHITE, NJ TI IMMUNE CELL ACTIVATION IN MELIOIDOSIS - INCREASED SERUM LEVELS OF INTERFERON-GAMMA AND SOLUBLE INTERLEUKIN-2 RECEPTORS WITHOUT CHANGE IN SOLUBLE CD8 PROTEIN SO JOURNAL OF INFECTIOUS DISEASES LA English DT Note AB To evaluate immune cell activation in patients with melioidosis, serum samples were assayed for interferon-gamma (IFN-gamma), soluble interleukin-2 receptors (sIL-2R), and soluble CD8 protein (sCD8). Forty patients with sepsis (23 fatal cases, 17 survivors) and 13 with localized disease were studied during acute illness; 12 additional patients were studied after discharge while on maintenance antimicrobial therapy. Serum concentrations of IFN-gamma and sIL-2R were greatly elevated, but sCD8 concentrations were not. These levels increased with disease severity and were associated with fatal outcomes. Macrophage activation by high concentrations of the cytokine IFN-gamma may contribute to pathophysiology and death in septicemic patients. Both IFN-gamma and sIL-2R seem to be predictive of outcome in patients with severe melioidosis and may prove useful in detection of relapse. C1 MAHIDOL UNIV,FAC TROP MED,BANGKOK 10700,THAILAND. SAPPASITPRASONG HOSP,UBON RATCHATHANI,THAILAND. UNIV OXFORD,NUFFIELD DEPT CLIN MED,TROP MED UNIT,OXFORD,ENGLAND. RP BROWN, AE (reprint author), ARMED FORCES RES INST MED SCI,DEPT IMMUNOL,315-6 RAJVITHI RD,BANGKOK 10400,THAILAND. RI White, Nicholas/I-4629-2012 FU Wellcome Trust NR 14 TC 27 Z9 27 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD MAY PY 1991 VL 163 IS 5 BP 1145 EP 1148 PG 4 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA FH745 UT WOS:A1991FH74500033 PM 1902247 ER PT J AU MOYER, MP GENDELMAN, HE AF MOYER, MP GENDELMAN, HE TI HIV REPLICATION AND PERSISTENCE IN HUMAN GASTROINTESTINAL CELLS CULTURED INVITRO SO JOURNAL OF LEUKOCYTE BIOLOGY LA English DT Article DE ACQUIRED IMMUNE DEFICIENCY SYNDROME (AIDS); VIRUS PERSISTENCE; VIRUS LATENCY; CELL CULTURE MODELS; KAPOSIS SARCOMA ID HUMAN IMMUNODEFICIENCY VIRUS; LONG-TERM CULTURE; KAPOSIS SARCOMA; AIDS; INFECTION; ENTEROPATHY; RETROVIRUS; DISEASE; MARKERS; CRYPTS AB Epithelial and submucosal mesenchymal (SM) cells from normal human small intestine and colon could be directly infected by several strains of the human immunodeficiency virus (HIV). Macrophage-derived virus strains were more potent than the HTLVIIIB prototype strain. Persistent release of virus over several months implies that the human gastrointestinal tract may serve as a site for primary infection and as a reservoir for the virus. Furthermore, HIV infection of SM cells may be an in vitro model of Kaposi's sarcoma. C1 UNIV TEXAS,HLTH SCI CTR,DEPT MICROBIOL,CTR HUMAN CELL BIOTECHNOL,SAN ANTONIO,TX 78284. UNIFORMED SERV UNIV HLTH SCI,HENRY M JACKSON FDN,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,DEPT CELLULAR IMMUNOL,HIV IMMUNOPATHOGENESIS PROGRAM,WASHINGTON,DC 20307. RP MOYER, MP (reprint author), UNIV TEXAS,HLTH SCI CTR,DEPT SURG,CTR HUMAN CELL BIOTECHNOL,7703 FLOYD CURL DR,SAN ANTONIO,TX 78284, USA. FU NIDDK NIH HHS [DK40625] NR 43 TC 21 Z9 21 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0741-5400 J9 J LEUKOCYTE BIOL JI J. Leukoc. Biol. PD MAY PY 1991 VL 49 IS 5 BP 499 EP 504 PG 6 WC Cell Biology; Hematology; Immunology SC Cell Biology; Hematology; Immunology GA FH273 UT WOS:A1991FH27300010 PM 2016570 ER PT J AU PETRARCA, V BEIER, JC ONYANGO, F KOROS, J ASIAGO, C KOECH, DK ROBERTS, CR AF PETRARCA, V BEIER, JC ONYANGO, F KOROS, J ASIAGO, C KOECH, DK ROBERTS, CR TI SPECIES COMPOSITION OF THE ANOPHELES-GAMBIAE COMPLEX (DIPTERA, CULICIDAE) AT 2 SITES IN WESTERN KENYA SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE INSECTA; ANOPHELES-GAMBIAE COMPLEX; MALARIA; KENYA ID IMMUNOSORBENT-ASSAY ELISA; KISUMU AREA; SPOROZOITE DETECTION; OMS-43 FENITROTHION; GILES COMPLEX; ARABIENSIS; DIFFERENTIATION; TRANSMISSION; ANTIBODIES; MOSQUITOS AB At two sites in the Kisumu area of western Kenya, the species composition of the Anopheles gambiae complex was determined by analysis of ovarian polytene chromosomes. Of 1,915 females, 26.1% were An. arabiensis Patton and 73.9% were An. gambiae Giles; one arabiensis x gambiae hybrid was identified. No major differences in the proportions of An. arabiensis and An. gambiae were observed between sites or between years. The ratio of An. arabiensis / An. gambiae was 6.7:1 (n = 231) in cow-baited traps, 0.2:1 (n = 1,525) in indoor resting samples, and 0.5:1 (n = 145) in all-night human bait catches. The proportion of An. arabiensis decreased progressively from 50.0% to 8.3% (n = 1,129) during 11 wk from September to November 1987; this change was correlated negatively with night temperature and positively with temperature range. In cow-baited traps, 97.4% (n = 194) of An. arabiensis were cow-fed and 95.8% (n = 1,054) of An. gambiae from indoor resting collections were human-fed. In indoor collections, 37.2% (n = 215) of An. arabiensis were cow-fed and 23.1% (n = 26) of An. gambiae from cow traps were human-fed. This demonstrates post-blood-feeding endophily by An. arabiensis and suggests post-blood-feeding exophily by An. gambiae. Malaria infection rates were higher for An. gambiae than for An. arabiensis by a ratio of 3:1 in 1986 (by Plasmodium falciparum ELISA) and 2.3:1 in 1987 (by dissection). Despite the higher proportion of infective An. gambiae, both species in this area serve as efficient vectors through their remarkably stable contact with the human population as demonstrated by their blood feeding and resting behavior. C1 KENYA GOVT MED RES CTR,NAIROBI,KENYA. USA,MED RES UNIT,APO,NEW YORK,NY 09675. JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,DEPT IMMUNOL & INFECT DIS,BALTIMORE,MD 21205. RP PETRARCA, V (reprint author), UNIV ROME LA SAPIENZA,IST PARASSITOL,PIAZZALE ALDO MORO 5,I-00185 ROME,ITALY. NR 25 TC 60 Z9 61 U1 0 U2 3 PU ENTOMOL SOC AMER PI LANHAM PA 9301 ANNAPOLIS RD, LANHAM, MD 20706 SN 0022-2585 J9 J MED ENTOMOL JI J. Med. Entomol. PD MAY PY 1991 VL 28 IS 3 BP 307 EP 313 PG 7 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA FK857 UT WOS:A1991FK85700003 PM 1875359 ER PT J AU LINTHICUM, KJ LOGAN, TM BAILEY, CL GORDON, SW PETERS, CJ MONATH, TP OSORIO, J FRANCY, DB MCLEAN, RG LEDUC, JW GRAHAM, RR JAHRLING, PB MOULTON, JR DOHM, DJ AF LINTHICUM, KJ LOGAN, TM BAILEY, CL GORDON, SW PETERS, CJ MONATH, TP OSORIO, J FRANCY, DB MCLEAN, RG LEDUC, JW GRAHAM, RR JAHRLING, PB MOULTON, JR DOHM, DJ TI VENEZUELAN EQUINE ENCEPHALOMYELITIS VIRUS-INFECTION IN AND TRANSMISSION BY THE TICK AMBLYOMMA-CAJENNENSE (ARACHNIDA, IXODIDAE) SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE ARACHNIDA; VENEZUELAN EQUINE ENCEPHALOMYELITIS; AMBLYOMMA-CAJENNENSE; ALPHAVIRUS ID HYALOMMA-TRUNCATUM; FEVER VIRUS; DISAPPEARANCE; KOCH AB To assess a possible role of ticks as the maintenance host for epizootic strains of Venezuelan equine encephalomyelitis (VEE) virus, laboratory experiments were conducted to determine if ticks could become infected, maintain, and transmit the virus. Larval and nymphal Amblyomma cajennense (F.) and larval Dermacentor nitens Neumann ticks were exposed to epizootic VEE virus (Trinidad donkey strain) by allowing them to feed on viremic guinea pigs (strain 13). In A. cajennense, transstadial transmission was observed from larvae to nymphs and adults. Horizontal viral transmission to a mammalian host was accomplished by nymphs. Infection rates in nymphs and adults were 2% (42/2,750) and 4% (9/244), respectively, after ingestion of virus as larvae. Virus was detected in A. cajennense adult ticks for up to 171 d after infection in the larval stage. A. cajennense, exposed as nymphs, ingested virus but did not become infected (0/164 after 10 d after taking an infective bloodmeal). No virus was detected in D. nitens 7 d after exposure. These findings suggest that A. cajennense potentially could be involved in an interepizootic maintenance cycle of epizootic VEE viral strains. RP LINTHICUM, KJ (reprint author), USA,MED RES INST INFECT DIS,DEPT ARBOVIRAL ENTOMOL,DIV VIROL,FT DETRICK,FREDERICK,MD 21702, USA. RI Gordon, Scott/B-8875-2011 NR 21 TC 21 Z9 21 U1 0 U2 1 PU ENTOMOL SOC AMER PI LANHAM PA 9301 ANNAPOLIS RD, LANHAM, MD 20706 SN 0022-2585 J9 J MED ENTOMOL JI J. Med. Entomol. PD MAY PY 1991 VL 28 IS 3 BP 405 EP 409 PG 5 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA FK857 UT WOS:A1991FK85700016 PM 1875367 ER PT J AU ROBERT, LL HALLAM, JA SEELEY, DC ROBERTS, LW WIRTZ, RA AF ROBERT, LL HALLAM, JA SEELEY, DC ROBERTS, LW WIRTZ, RA TI COMPARATIVE SENSITIVITY OF 4 ANOPHELES (DIPTERA, CULICIDAE) TO 5 REPELLENTS SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE INSECTA; ANOPHELES SPP; REPELLENTS ID MOSQUITO REPELLENTS; AEDES-AEGYPTI; PERMETHRIN; ALBIMANUS; QUADRIMACULATUS; PSYCHODIDAE; EFFICACY; DEET AB Five repellents were evaluated against Anopheles albimanus Wiedemann, An. freeborni Aitken, An. gambiae Giles, and An. stephensi Liston, using a "free choice," dose-response testing procedure on rabbits. Overall, deet was the most effective repellent based on effective dosages (ED50's and ED95's), except against An. albimanus. An. albimanus was significantly more tolerant to deet compared with dimethyl phthalate or ethyl hexanediol. Permethrin was effective against all four anopheline species at the ED50 levels; however, the ED95 values were higher compared with the other repellents. There were significant differences in sensitivity of some of the four species to all the repellents tested, except dimethyl phthalate and indalone. The variability in the response of these anopheline species to repellents confirm that the extrapolation of repellent data from one anopheline species to another is unreliable and that comprehensive tests are needed for each species. RP ROBERT, LL (reprint author), WALTER REED ARMY MED CTR,DEPT ENTOMOL,DIV COMMUNICABLE DIS & IMMUNOL,WASHINGTON,DC 20307, USA. NR 20 TC 19 Z9 22 U1 0 U2 1 PU ENTOMOL SOC AMER PI LANHAM PA 9301 ANNAPOLIS RD, LANHAM, MD 20706 SN 0022-2585 J9 J MED ENTOMOL JI J. Med. Entomol. PD MAY PY 1991 VL 28 IS 3 BP 417 EP 420 PG 4 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA FK857 UT WOS:A1991FK85700018 PM 1875369 ER PT J AU WILSON, LY FAMINI, GR AF WILSON, LY FAMINI, GR TI USING THEORETICAL DESCRIPTORS IN QUANTITATIVE STRUCTURE-ACTIVITY-RELATIONSHIPS - SOME TOXICOLOGICAL INDEXES SO JOURNAL OF MEDICINAL CHEMISTRY LA English DT Article ID SOLVATION ENERGY RELATIONSHIPS; SOLUBILITY PROPERTIES; BIOLOGICAL MEDIA; ORGANIC NONELECTROLYTES; FISH TOXICITY; PI-STAR; POLYMERS; PARAMETERS; POLLUTANTS; MOLECULES AB The application of computational techniques to medicinal chemistry is growing at a tremendous rate. Quantitative structure-activity relationships (QSAR), which relate biological and toxicological activities to structural features, have been employed widely to correlate structure to activity. A difficulty of this approach has been nonuniformity of parameter sets and the inability to examine contributions across properties and data sets. Linear solvation energy relationships (LSER) developed by Kamlet and Taft circumvent many of the difficulties and successfully utilize a single set of parameters for a wide range of physical, chemical and biological properties. We have replaced the LSER solvato-chromatic parameters with theoretically determined parameters to permit better a priori prediction of properties. Comparison of the two parameter sets for five biological activities is presented, showing the excellent fit of the theoretically determined parameters. C1 USA,CTR CHEM RES DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010. RP WILSON, LY (reprint author), LOMA LINDA UNIV RIVERSIDE,DEPT CHEM,RIVERSIDE,CA 92515, USA. NR 34 TC 105 Z9 128 U1 2 U2 14 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0022-2623 J9 J MED CHEM JI J. Med. Chem. PD MAY PY 1991 VL 34 IS 5 BP 1668 EP 1674 DI 10.1021/jm00109a021 PG 7 WC Chemistry, Medicinal SC Pharmacology & Pharmacy GA FL859 UT WOS:A1991FL85900021 PM 2033592 ER PT J AU MCHALE, KA LENHART, MK AF MCHALE, KA LENHART, MK TI TREATMENT OF RESIDUAL CLUBFOOT DEFORMITY THE BEAN-SHAPED FOOT BY OPENING WEDGE MEDIAL CUNEIFORM OSTEOTOMY AND CLOSING WEDGE CUBOID OSTEOTOMY - CLINICAL REVIEW AND CADAVER CORRELATIONS SO JOURNAL OF PEDIATRIC ORTHOPAEDICS LA English DT Article DE BEAN-SHAPED FOOT; CLUBFOOT; RECURRENT CLUBFOOT; RELAPSED CLUBFOOT; RESIDUAL CLUBFOOT; REVISION CLUBFOOT AB Six patients (seven feet) previously treated surgically for clubfoot had a "bean-shaped" foot. Opening wedge medial cuneiform and closing wedge cuboid osteotomies were done, resulting in good resolution of the prominent midfoot supination and forefoot adductus without significant soft tissue dissection and invasion of growing areas in the foot. Cadaver reproductions show that the cuboid closing wedge is responsible for the change in the midfoot, whereas the cuboid and cuneiform osteotomies both contribute to the change in the forefoot. RP MCHALE, KA (reprint author), WALTER REED ARMY MED CTR,DEPT ORTHOPED SURG,WASHINGTON,DC 20307, USA. NR 0 TC 34 Z9 35 U1 0 U2 1 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0271-6798 J9 J PEDIATR ORTHOPED JI J. Pediatr. Orthop. PD MAY-JUN PY 1991 VL 11 IS 3 BP 374 EP 381 PG 8 WC Orthopedics; Pediatrics SC Orthopedics; Pediatrics GA FG794 UT WOS:A1991FG79400017 PM 2056088 ER PT J AU LILLEY, JS ARSZMAN, JH AF LILLEY, JS ARSZMAN, JH TI SCARFED NOZZLES FOR THRUST-VECTOR ADJUSTMENT SO JOURNAL OF PROPULSION AND POWER LA English DT Article AB This paper presents the results of an investigation into the utilization of scarfed nozzles for thrust-vector adjustment. The investigation was conducted to determine the feasibility of utilizing scarfed nozzles on tactical missiles employing multiple strap-on solid rocket boosters. This approach offers an effective and low-cost method for aligning the thrust vector with the missile center of gravity. The use of such nozzles provides a means of minimizing the impact of booster-to-booster performance variation on missile angular velocity while having a minimal impact on individual booster performance. A previously developed scarfed nozzle performance-prediction computer code served as the primary theoretical analysis tool. This code was utilized to conduct an extensive parametric study that characterized the influence of scarfed nozzle geometry and nozzle operating pressure on the direction and magnitude of the thrust vector. The influence of scarfed nozzle geometry on the thrust vector was also experimentally investigated by statically firing specially designed solid rocket motors that employed scarfed nozzles. The data from the experimental motor firing were compared to performance predictions generated by the theoretical model. Design implications and concept limitations are addressed. RP LILLEY, JS (reprint author), USA,MISSILE COMMAND,PROP DIRECTORATE,REDSTONE ARSENAL,AL 35898, USA. NR 3 TC 1 Z9 1 U1 1 U2 1 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091 SN 0748-4658 J9 J PROPUL POWER JI J. Propul. Power PD MAY-JUN PY 1991 VL 7 IS 3 BP 382 EP 388 DI 10.2514/3.23338 PG 7 WC Engineering, Aerospace SC Engineering GA FU462 UT WOS:A1991FU46200011 ER PT J AU SOMMERS, RJ AF SOMMERS, RJ TI THE UNION-ARMY, 1861-1865 - ORGANIZATION AND OPERATIONS, VOL 1, THE EASTERN THEATER - WELCHER,FJ SO JOURNAL OF SOUTHERN HISTORY LA English DT Book Review RP SOMMERS, RJ (reprint author), USA,INST MIL HIST,WASHINGTON,DC 20310, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOUTHERN HISTORICAL ASSN PI ATHENS PA UNIV GEORGIA HISTORY DEPT, ATHENS, GA 30602 SN 0022-4642 J9 J SOUTHERN HIST JI J. South. Hist. PD MAY PY 1991 VL 57 IS 2 BP 333 EP 335 DI 10.2307/2210442 PG 3 WC History SC History GA FL718 UT WOS:A1991FL71800029 ER PT J AU WAKEFIELD, PE JAMES, WD SAMLASKA, CP MELTZER, MS AF WAKEFIELD, PE JAMES, WD SAMLASKA, CP MELTZER, MS TI TUMOR-NECROSIS-FACTOR SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Review ID INDUCED ANTIGEN EXPRESSION; SHOCK-SYNDROME TOXIN-1; FACTOR TNF-ALPHA; PHASE-I TRIAL; FACTOR CACHECTIN; HUMAN KERATINOCYTES; INTERFERON-GAMMA; CUTANEOUS INFLAMMATION; KAPOSIS SARCOMA; HUMAN-MONOCYTES AB Tumor necrosis factor is important in systemic and cutaneous defense, homeostasis, and many disease states. The numerous and diverse effects of tumor necrosis factor are best understood when considered as concentration-dependent, with normal homeostasis progressing to defense followed by toxic effects. Understanding tumor necrosis factor is important for the dermatologist as more studies appear in our literature and potential clinical uses of tumor necrosis factor (and possible anti-tumor necrosis factor agents) are realized. C1 WALTER REED ARMY MED CTR,DEPT CELLULAR IMMUNOL,WASHINGTON,DC 20307. TRIPLER ARMY MED CTR,DERMATOL SERV,HONOLULU,HI 96859. RP WAKEFIELD, PE (reprint author), WALTER REED ARMY MED CTR,DERMATOL SERV,WASHINGTON,DC 20307, USA. NR 110 TC 74 Z9 77 U1 0 U2 4 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD MAY PY 1991 VL 24 IS 5 BP 675 EP 685 DI 10.1016/0190-9622(91)70102-8 PN 1 PG 11 WC Dermatology SC Dermatology GA FJ266 UT WOS:A1991FJ26600001 PM 1869638 ER PT J AU SMITH, KJ SKELTON, HG JAMES, WD BARRETT, TL ANDERSON, DW ANGRITT, P AF SMITH, KJ SKELTON, HG JAMES, WD BARRETT, TL ANDERSON, DW ANGRITT, P TI ANGIOSARCOMA ARISING IN KAPOSIS-SARCOMA (PLEOMORPHIC KAPOSIS-SARCOMA) IN A PATIENT WITH HUMAN-IMMUNODEFICIENCY-VIRUS DISEASE SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Note C1 ARMED FORCES INST PATHOL,DEPT DERMATOPATHOL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. SCRIPPS CLIN & RES FDN,AIDS REGISTRY,LA JOLLA,CA 92037. WALTER REED ARMY MED CTR,DEPT DERMATOL,WASHINGTON,DC 20307. NR 9 TC 7 Z9 7 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD MAY PY 1991 VL 24 IS 5 BP 790 EP 792 DI 10.1016/S0190-9622(08)80375-1 PN 1 PG 3 WC Dermatology SC Dermatology GA FJ266 UT WOS:A1991FJ26600028 PM 1869659 ER PT J AU LIPP, LJ AF LIPP, LJ TI DESIGN CONSIDERATION OF EXPANDER HEADS FOR VIBRATION TESTING .2. DAMPING EQUATIONS FOR SQUARE, CONSTANT THICKNESS EXPANDER HEADS SO JOURNAL OF THE IES LA English DT Article DE EXPANDER HEAD; VIBRATION TEST FIGURE; TEST FIXTURE RESONANCE; TEST FIXTURE DAMPING RP LIPP, LJ (reprint author), USA,ARMAMENT MUNIT & CHEM COMMAND,ABERDEEN PROVING GROUND,MD 21010, USA. NR 0 TC 0 Z9 0 U1 1 U2 1 PU INST ENVIRONMENTAL SCI PI MT PROSPECT PA 940 E NORTHWEST HIGHWAY, MT PROSPECT, IL 60056 SN 1052-2883 J9 J IES JI J. IES PD MAY-JUN PY 1991 VL 34 IS 3 BP 23 EP 29 PG 7 WC Engineering, Environmental; Environmental Sciences; Instruments & Instrumentation SC Engineering; Environmental Sciences & Ecology; Instruments & Instrumentation GA FU978 UT WOS:A1991FU97800002 ER PT J AU BOWDEN, CM POSTAN, A INGUVA, R AF BOWDEN, CM POSTAN, A INGUVA, R TI INVARIANT PULSE-PROPAGATION AND SELF-PHASE MODULATION IN DENSE MEDIA SO JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICS LA English DT Article ID MIRRORLESS OPTICAL BISTABILITY; LOCAL-FIELD CORRECTION; 2-LEVEL ATOMS; INDUCED TRANSPARENCY; TRANSITION; SUPERFLUORESCENCE; SYSTEM AB Analytical solutions for the slowly varying phase as well as the field amplitude are obtained for invariant pulse propagation in resonant absorbing media consisting of interacting two-level atoms. Such media, having many atoms within a cubic wavelength, have been shown to exhibit large frequency chirps in pulse propagation owing to near-dipole-dipole interactions. Departures from hyperbolic-secant pulse envelopes and pulse areas other than 2-pi have been shown to occur in invariant pulse propagation. We show that self-phase modulation results from the near-dipole-dipole interactions and can cause strong modification of pulse shapes, including temporal narrowing and multipulse behavior. C1 NASA,GEORGE C MARSHALL SPACE FLIGHT CTR,HUNTSVILLE,AL 35812. RP BOWDEN, CM (reprint author), USA,MISSILE COMMAND,CTR RES DEV & ENGN,AMSMI RD WS,WEAPONS SCI DIRECTORATE,REDSTONE ARSENAL,AL 35898, USA. NR 15 TC 41 Z9 42 U1 0 U2 3 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0740-3224 J9 J OPT SOC AM B JI J. Opt. Soc. Am. B-Opt. Phys. PD MAY PY 1991 VL 8 IS 5 BP 1081 EP 1084 DI 10.1364/JOSAB.8.001081 PG 4 WC Optics SC Optics GA FL116 UT WOS:A1991FL11600024 ER PT J AU BENARYEH, Y BOWDEN, CM AF BENARYEH, Y BOWDEN, CM TI QUANTUM FLUCTUATIONS IN INTRINSIC BISTABILITY OF A 2-LEVEL SYSTEM SO JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICS LA English DT Article ID MIRRORLESS OPTICAL BISTABILITY; SQUEEZED STATES; RESONANCE FLUORESCENCE; LIGHT; ATOMS; NOISE; ABSORPTION; GENERATION; 1ST-ORDER; MODEL AB The quantum fluctuations in intrinsic bistability of a two-level system are calculated by means of Einstein relations. All the second moments of the dipole operators are calculated, and the statistical properties of the reaction field are studied. It is found that quantum noise that is above the standard quantum limit is inherent in the reaction field. C1 USA,MISSILE COMMAND,CTR RES DEV & ENGN,RES DIRECTORATE,REDSTONE ARSENAL,AL 35898. RP BENARYEH, Y (reprint author), TECHNION ISRAEL INST TECHNOL,DEPT PHYS,IL-32000 HAIFA,ISRAEL. NR 40 TC 4 Z9 4 U1 0 U2 1 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0740-3224 J9 J OPT SOC AM B JI J. Opt. Soc. Am. B-Opt. Phys. PD MAY PY 1991 VL 8 IS 5 BP 1168 EP 1173 DI 10.1364/JOSAB.8.001168 PG 6 WC Optics SC Optics GA FL116 UT WOS:A1991FL11600037 ER PT J AU MCLANE, GF MEYYAPPAN, M LEE, H BUCKWALD, W AF MCLANE, GF MEYYAPPAN, M LEE, H BUCKWALD, W TI MAGNETRON ENHANCED ETCHING OF GAAS SO JOURNAL OF VACUUM SCIENCE & TECHNOLOGY A-VACUUM SURFACES AND FILMS LA English DT Article; Proceedings Paper CT 37TH NATIONAL SYMP OF THE AMERICAN VACUUM SOC CY OCT 08-12, 1990 CL TORONTO, CANADA SP AMER VACUUM SOC ID ION; DAMAGE; PLASMA; CF4; CHEMISTRY AB Magnetron reactive ion etching of GaAs in a freon-12 discharge has been studied. Electrical characteristics of the etched samples were investigated by current-voltage and capacitance-voltage measurements on Schottky diodes. The ideality factors were found to be close to that of the control sample. Magnetron etching causes no apparent change in the carrier concentration profile. Magnetron enhancement is shown to yield high etch rates with minimal residual damage to the wafer. C1 SCI RES ASSOCIATES INC,GLASTONBURY,CT 06033. RP MCLANE, GF (reprint author), USA,ELECTR TECHNOL & DEVICES LAB,FT MONMOUTH,NJ 07703, USA. NR 18 TC 11 Z9 11 U1 0 U2 1 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0734-2101 J9 J VAC SCI TECHNOL A JI J. Vac. Sci. Technol. A-Vac. Surf. Films PD MAY-JUN PY 1991 VL 9 IS 3 BP 935 EP 938 DI 10.1116/1.577550 PN 1 PG 4 WC Materials Science, Coatings & Films; Physics, Applied SC Materials Science; Physics GA FR761 UT WOS:A1991FR76100110 ER PT J AU QADRI, SB AF QADRI, SB TI X-RAY CHARACTERIZATION OF (ZN,CD)TE CDTE STRAINED LAYER SUPERLATTICES SO JOURNAL OF VACUUM SCIENCE & TECHNOLOGY A-VACUUM SURFACES AND FILMS LA English DT Article; Proceedings Paper CT 37TH NATIONAL SYMP OF THE AMERICAN VACUUM SOC CY OCT 08-12, 1990 CL TORONTO, CANADA SP AMER VACUUM SOC AB The structural properties of molecular beam epitaxially (MBE) grown (Zn,Cd)Te/CdTe superlattices on InSb substrates have been investigated using x-ray double crystal rocking curves and topographs. The value of unit cell parameters a perpendicular-to and a parallel-to have been obtained for (Zn,Cd)Te layers from the theta/2-theta-scans of (004) and (444) reflections and their relaxed parameters calculated. Rocking curve measurements show that for (004) reflection the full-width at half-maximum (FWHM) of the superlattice is significantly reduced when compared with that for ZnCdTe layer of comparable Zn composition. The narrow rocking curves for the central and the satellite peaks suggest that the interfaces are very sharp and the superlattice periods do not fluctuate. RP QADRI, SB (reprint author), USA,NAVAL RES LAB,WASHINGTON,DC 20375, USA. NR 4 TC 0 Z9 0 U1 0 U2 1 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0734-2101 J9 J VAC SCI TECHNOL A JI J. Vac. Sci. Technol. A-Vac. Surf. Films PD MAY-JUN PY 1991 VL 9 IS 3 BP 954 EP 956 DI 10.1116/1.577555 PN 1 PG 3 WC Materials Science, Coatings & Films; Physics, Applied SC Materials Science; Physics GA FR761 UT WOS:A1991FR76100114 ER PT J AU DEAN, BE JOHNSON, CJ MCDEVITT, SC NEUGEBAUER, GT SEPICH, JL DOBBYN, RC KURIYAMA, M ELLSWORTH, J VYDYANATH, HR KENNEDY, JJ AF DEAN, BE JOHNSON, CJ MCDEVITT, SC NEUGEBAUER, GT SEPICH, JL DOBBYN, RC KURIYAMA, M ELLSWORTH, J VYDYANATH, HR KENNEDY, JJ TI CORRELATION OF HGCDTE EPILAYER DEFECTS WITH UNDERLYING SUBSTRATE DEFECTS BY SYNCHROTRON X-RAY TOPOGRAPHY SO JOURNAL OF VACUUM SCIENCE & TECHNOLOGY B LA English DT Article; Proceedings Paper CT 1990 US WORKSHOP ON THE PHYSICS AND CHEMISTRY OF MERCURY CADMIUM TELLURIDE AND NOVEL INFRARED DETECTOR MATERIALS CY OCT 02-04, 1990 CL SAN FRANCISCO, CA SP COMMUNICAT ELECTRON COMMAND CTR NIGHT VIS & ELECTRO OPT, USN, OFF NAVAL TECHNOL, ASAF, OFF SCI RES, AMER VACUUM SOC ID DIFFRACTION IMAGING TOPOGRAPHY; GROWTH; RADIATION AB Synchrotron x-ray topography studies have been conducted at the National Synchhrotron Light Source at Brookhaven National Laboratory to correlate defects in HcCdTe epilayers with those in underlying CdTe family substrates. Infrared detectors have been fabricated on these epilayers to investigate the performance impact of specific defects. This paper describes synchrotron x-ray facilities and methods. Images of substrates and epilayer are discussed and mapping of epolayer/substrate defects, such as microtwins, subgrain boundaries and slip lines, is demonstrated. Efforts to map detector array performance to epilayer and substrate topographs are described. C1 NATL INST STAND & TECHNOL,GAITHERSBURG,MD 20899. AEROJET ELECTROSYST CO,AZUSA,CA 91702. USA,CECOM,CNVEO,FT BELVOIR,VA 22060. RP DEAN, BE (reprint author), II-VI INC,SAXONBURG,PA 16056, USA. NR 14 TC 5 Z9 5 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 1071-1023 J9 J VAC SCI TECHNOL B JI J. Vac. Sci. Technol. B PD MAY-JUN PY 1991 VL 9 IS 3 BP 1840 EP 1846 DI 10.1116/1.585809 PG 7 WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology; Physics, Applied SC Engineering; Science & Technology - Other Topics; Physics GA FR866 UT WOS:A1991FR86600072 ER PT J AU DUBOIS, DR ECKELS, KH TICEHURST, J BINN, LN TIMCHAK, RL BARVIR, DA RANKIN, CT ONEILL, SP AF DUBOIS, DR ECKELS, KH TICEHURST, J BINN, LN TIMCHAK, RL BARVIR, DA RANKIN, CT ONEILL, SP TI LARGE-SCALE PURIFICATION OF INACTIVATED HEPATITIS-A VIRUS BY CENTRIFUGATION IN NONIONIC GRADIENTS SO JOURNAL OF VIROLOGICAL METHODS LA English DT Note DE HEPATITIS-A VIRUS; HEPATITIS-A VACCINE; CENTRIFUGATION; PURIFICATION ID PARTICLES; DENSITY; CSCL AB Formalin-inactivated hepatitis A virus (HAV) can be purified for vaccine preparation by centrifugation in Renografin-76 (diatrizoate meglumine and diatrizoate sodium) gradients. Both continuous-flow rate-zonal and isopycnic methods were used for the separation of a major antigen component from minor antigen and host protein. The major antigen component, which appeared to contain complete virions by electron microscopy, could be recovered from gradients and accounted for approximately one third of the total antigen in the starting material. The HAV-specific purified antigen could be enriched 200-300-fold by either centrifugation procedure. The purified HAV antigen, when adsorbed to alum and inoculated into mice, was found to be highly immunogenic. C1 WALTER REED ARMY MED CTR,DIV COMMUNICABLE DIS & IMMUNOL,WASHINGTON,DC 20307. ELECTRONUCLEONICS INC,SILVER SPRING,MD. RI Ticehurst, John/I-7532-2012 NR 12 TC 7 Z9 7 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-0934 J9 J VIROL METHODS JI J. Virol. Methods PD MAY PY 1991 VL 32 IS 2-3 BP 327 EP 334 DI 10.1016/0166-0934(91)90062-5 PG 8 WC Biochemical Research Methods; Biotechnology & Applied Microbiology; Virology SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Virology GA FU983 UT WOS:A1991FU98300020 PM 1651954 ER PT J AU CUTTNER, J MICK, R BUDMAN, DR MAYER, RJ LEE, EJ HENDERSON, ES WEISS, RB PACIUCCI, PA SOBOL, R DAVEY, F BLOOMFIELD, C SCHIFFER, C AF CUTTNER, J MICK, R BUDMAN, DR MAYER, RJ LEE, EJ HENDERSON, ES WEISS, RB PACIUCCI, PA SOBOL, R DAVEY, F BLOOMFIELD, C SCHIFFER, C TI PHASE-III TRIAL OF BRIEF INTENSIVE TREATMENT OF ADULT ACUTE LYMPHOCYTIC-LEUKEMIA COMPARING DAUNORUBICIN AND MITOXANTRONE - A CALGB STUDY SO LEUKEMIA LA English DT Article ID ACUTE LYMPHOBLASTIC-LEUKEMIA; THERAPY; ASPARAGINASE; INDUCTION; CANCER AB This paper reports a study of the Cancer and Leukemia Group B (CALGB) comparing daunorubicin (DNR) or mitoxantrone (DHAD) in induction followed by multidrug intensification over 8 months in adult patients with acute lymphocytic leukemia (ALL). A total of 164 newly diagnosed patients were randomly assigned to either DNR or DHAD plus vincristine, prednisone and methotrexate given intravenously (i.v.) and interthecally (i.t.). Patients received four more intensification courses of chemotherapy and then all therapy was stopped. Central nervous system (CNS) prophylaxis consisted of nine infusions of intermediate dose methotrexate (MTX) and intrathecal MTX. DHAD and DNR were equally effective in producing complete remissions (63 and 65%, respectively). The estimated median remission duration is 10.2 and 12.3 months for the DHAD and DNR arms, respectively (p = 0.56). This study was stopped earlier than planned when it became apparent that remission duration for both arms was shorter than seen in our prior study in which all patients received more than 1 year of maintenance therapy. The estimated median survival is 18.3 and 20.6 months for the DHAD and DNR arms, respectively (p = 0.90). Younger patients and patients with a pre-treatment white blood count of less than 30 000/mu-l had a significantly longer remission duration and survival. Eleven per cent of patients who achieved a complete remission have had a CNS relapse to date, which is not different from the rate in our prior study using cranial irradiation and i.t. MTX, implying that intermediate dose MTX with i.t. MTX may be as effective as cranial irradiation and i.t. MTX. This study suggests that some form of maintenance chemotherapy is required for the eradication of residual leukemia cells. C1 UNIV CHICAGO,MED CTR,CHICAGO,IL 60637. N SHORE UNIV HOSP,MANHASSET,NY 11030. HARVARD UNIV,SCH PUBL HLTH,BOSTON,MA 02115. UNIV MARYLAND,CTR CANC,BALTIMORE,MD 21201. NEW YORK STATE DEPT HLTH,ROSWELL PK MEM INST,BUFFALO,NY 14263. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. UNIV CALIF SAN DIEGO,LA JOLLA,CA 92093. SUNY HLTH SCI CTR,SYRACUSE,NY. RP CUTTNER, J (reprint author), MT SINAI MED CTR,DIV HEMATOL,1 GUSTAVE L LEVY PL,BOX 1079,NEW YORK,NY 10029, USA. FU NCI NIH HHS [CA 04457, CA 07968-26, CA 33601] NR 17 TC 62 Z9 62 U1 0 U2 0 PU STOCKTON PRESS PI BASINGSTOKE PA HOUNDMILLS, BASINGSTOKE, HAMPSHIRE, ENGLAND RG21 6XS SN 0887-6924 J9 LEUKEMIA JI Leukemia PD MAY PY 1991 VL 5 IS 5 BP 425 EP 431 PG 7 WC Oncology; Hematology SC Oncology; Hematology GA FQ559 UT WOS:A1991FQ55900012 PM 2033963 ER PT J AU PARKS, AR THOMAS, ED AF PARKS, AR THOMAS, ED TI PHYSICAL SCALE MODELING VERIFICATION WITH SHIPBOARD TRIALS SO MATERIALS PERFORMANCE LA English DT Article AB The U.S. Navy has investigated and implemented design improvements for shipboard impressed current cathodic protection systems. Laboratory scale model testing was used to achieve an improved, two-zone system design. The redesigned system was installed aboard a test ship and data were gathered during sea trials to assess performance. Data acquired shipboard were correlated to laboratory work to assess the accuracy of the scale model design technique. RP PARKS, AR (reprint author), USA,NAVAL SEA SYST COMMAND,WASHINGTON,DC 20362, USA. NR 0 TC 7 Z9 11 U1 0 U2 0 PU NATL ASSN CORROSION ENG PI HOUSTON PA 1440 SOUTH CREEK DRIVE, HOUSTON, TX 77084-4906 SN 0094-1492 J9 MATER PERFORMANCE JI Mater. Perform. PD MAY PY 1991 VL 30 IS 5 BP 26 EP 29 PG 4 WC Materials Science, Characterization & Testing SC Materials Science GA FM304 UT WOS:A1991FM30400010 ER PT J AU SCHEIDLER, M AF SCHEIDLER, M TI TIME RATES OF GENERALIZED STRAIN TENSORS .1. COMPONENT FORMULAS SO MECHANICS OF MATERIALS LA English DT Article AB Hill derived a simple component formula for the material time derivative of a generalized Lagrangian strain tensor. We examine Hill's dervation in detail and explain why it is generally valid only when the principal stretches are distinct. We then give a proof of Hill's formula which is valid for any C2 motion and any C1 strain measure. Our proof is based on a component form of the chain rule for a tensor-valued function of a time-dependent symmetric tensor. This result is also used to derive component formulas for the Jaumann rate of a generalized Eulerian strain tensor. Finally, we apply the general formulas to the logarithmic strain tensors. RP SCHEIDLER, M (reprint author), USA,BALLIST RES LABS,ABERDEEN PROVING GROUND,MD 21005, USA. NR 0 TC 26 Z9 27 U1 0 U2 4 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-6636 J9 MECH MATER JI Mech. Mater. PD MAY PY 1991 VL 11 IS 3 BP 199 EP 210 DI 10.1016/0167-6636(91)90002-H PG 12 WC Materials Science, Multidisciplinary; Mechanics SC Materials Science; Mechanics GA FQ023 UT WOS:A1991FQ02300002 ER PT J AU SCHEIDLER, M AF SCHEIDLER, M TI TIME RATES OF GENERALIZED STRAIN TENSORS .2. APPROXIMATE BASIS-FREE FORMULAS SO MECHANICS OF MATERIALS LA English DT Article AB Utilizing the component formulas derived in Part I, we obtain approximate basis-free formulas for the material time derivative of a generalized Lagrangian strain tensor and for the Jaumann rate of a generalized Eulerian strain tensor. These formulas provide good approximations when the shear strains are small, regardless of the volumetric strain and the strain rate. We also derive explicit bounds for the error in the approximate formulas. By applying our general results to the logarithmic strain tensors, we obtain improved versions of approximate basis-free formulas due to Hill and Gurtin and Spear. RP SCHEIDLER, M (reprint author), USA,BALLIST RES LABS,ABERDEEN PROVING GROUND,MD 21005, USA. NR 0 TC 5 Z9 5 U1 1 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0167-6636 J9 MECH MATER JI Mech. Mater. PD MAY PY 1991 VL 11 IS 3 BP 211 EP 219 DI 10.1016/0167-6636(91)90003-I PG 9 WC Materials Science, Multidisciplinary; Mechanics SC Materials Science; Mechanics GA FQ023 UT WOS:A1991FQ02300003 ER PT J AU CARDELLO, AV DARSCH, G FITZGERALD, C GLEASON, SD TEIXEIRA, R AF CARDELLO, AV DARSCH, G FITZGERALD, C GLEASON, SD TEIXEIRA, R TI NUTRIENT, WASTE MANAGEMENT, AND HYGIENE SYSTEMS FOR CHEMICAL PROTECTIVE SUITS SO MILITARY MEDICINE LA English DT Article AB Current United States military chemical protective ensembles do not provide for feeding, removing body wastes, or ensuring the hygiene of troops operating in a contaminated environment. As part of a nuclear-biological-chemical life support demonstration program, systems were developed to provide these capabilities. The nutrient system consisted of foods packaged in tube dispensers and a delivery system compatible with North Atlantic Treaty Organization respirators. The waste management/hygiene systems consisted of waste collection and hygiene items incorporated into a retractable-arm suit design with integrated airlock. A field demonstration of the systems resulted in successful use by armored vehicle personnel, high, positive user feedback, and only minor functional problems. RP CARDELLO, AV (reprint author), USA,NATICK RES DEV & ENGN CTR,NATICK,MA 01760, USA. NR 0 TC 2 Z9 2 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAY PY 1991 VL 156 IS 5 BP 211 EP 215 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA FL572 UT WOS:A1991FL57200001 PM 2057069 ER PT J AU ROSEN, LN MOGHADAM, LZ AF ROSEN, LN MOGHADAM, LZ TI PATTERNS OF SEASONAL CHANGE IN MOOD AND BEHAVIOR - AN EXAMPLE FROM A STUDY OF MILITARY WIVES SO MILITARY MEDICINE LA English DT Article AB Three hundred ninety-seven Army wives located in Germany, California, and Texas answered a series of questions on seasonal changes in mood and behaviour as part of a general health survey. Subjects living in Germany reported significantly more symptoms associated with winter seasonal affective disorder than those living in Texas or California. RP ROSEN, LN (reprint author), WALTER REED ARMY MED CTR,DEPT MIL PSYCHIAT,5GRD UWI A,WASHINGTON,DC 20307, USA. NR 0 TC 5 Z9 5 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAY PY 1991 VL 156 IS 5 BP 228 EP 230 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA FL572 UT WOS:A1991FL57200005 PM 2057073 ER PT J AU MAURER, PK GEORGE, ED AF MAURER, PK GEORGE, ED TI SUBARACHNOID HEMORRHAGE DUE TO INTRACRANIAL ANEURYSM - CURRENT MANAGEMENT SO MILITARY MEDICINE LA English DT Article AB Intracranial aneurysms cause in excess of 28,000 subarachnoid hemorrhages per year in North America. The combined mortality and morbidity from aneurysmal subarachnoid hemorrhage exceeds 40%, and therefore yields a remarkably high toll of human and economic loss. As a lesion that is treatable, even curable at particular stages, management decisions are critical. In spite of significant advances in surgical technique, the mortality rate remains high. Erroneous diagnosis in good-grade patients significantly contributes to the lack of improvement in current statistics. Diagnosis and subsequent contemporary management is discussed. RP MAURER, PK (reprint author), WALTER REED ARMY MED CTR,NEUROSURG SERV,WASHINGTON,DC 20307, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAY PY 1991 VL 156 IS 5 BP 236 EP 239 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA FL572 UT WOS:A1991FL57200008 PM 2057076 ER PT J AU CHAPMAN, WHH FOLEY, KT LEE, YTM AF CHAPMAN, WHH FOLEY, KT LEE, YTM TI PULMONARY-EMBOLISM FROM A VENOUS THROMBOSIS DISTAL TO THE POPLITEAL VEIN SO MILITARY MEDICINE LA English DT Article AB A case of pulmonary embolism from a venous thrombosis distal to the popliteal vein is reported. This occurred despite venographic and ultrasound verification that the thrombus had not extended to the popliteal vein. The medical literature supports expectant treatment of "calf-only" venous thrombi. Our case clearly demonstrates that clinically significant pulmonary emboli can arise from calf vein thrombi without popliteal involvement. C1 TRIPLER ARMY MED CTR,DEPT SURG,HONOLULU,HI 96859. NR 0 TC 4 Z9 4 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAY PY 1991 VL 156 IS 5 BP 252 EP 254 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA FL572 UT WOS:A1991FL57200013 PM 2057079 ER PT J AU LEIDIG, GA AF LEIDIG, GA TI CLINICAL, ECHOCARDIOGRAPHIC, AND ELECTROCARDIOGRAPHIC RESOLUTION OF HIV-RELATED CARDIOMYOPATHY SO MILITARY MEDICINE LA English DT Article AB Congestive cardiomyopathy has been described in 18% (25/141) of studied patients with acquired immunodeficiency syndrome (AIDS) or AIDS-related complex, and myocarditis has been suspected as the etiology in 70% (14/20) of patients studied. In previous reports the cardiomyopathy has either been asymptomatic or has been progressive and directly caused significant patient mortality and morbidity. We report a patient with human immunodeficiency virus (HIV)-related cardiomyopathy due to a presumed myocarditis which caused life-threatening congestive heart failure and ventricular fibrillation. This patient's course was unique in that she had clinical, echocardiographic, and electrocardiographic resolution of her cardiomyopathy. This report adds new knowledge to the etiology and prognosis of patients with HIV-related cardiomyopathy. C1 KELLER ARMY COMMUNITY HOSP,DEPT INTERNAL MED,W POINT,NY 10996. NR 0 TC 5 Z9 5 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAY PY 1991 VL 156 IS 5 BP 260 EP 261 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA FL572 UT WOS:A1991FL57200016 PM 2057082 ER PT J AU ROSENBERG, ML JABBARI, B AF ROSENBERG, ML JABBARI, B TI MIOSIS AND INTERNAL OPHTHALMOPLEGIA AS A MANIFESTATION OF PARTIAL SEIZURES SO NEUROLOGY LA English DT Article ID UNILATERAL PUPILLARY DILATATION AB We present a patient whose only physical manifestation of a partial sensory seizure was bilateral pupillary constriction and internal ophthalmoplegia. The onset and offset of of each attack corresponded distinctly with an electroencephalographic discharge of the left temporo-occipital region. We propose involvement of a cortical pupillary constrictive center in the temporal-occipital area. C1 UNIFORMED SERV UNIV HLTH SCI,DEPT SURG,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,NEUROL SERV,WASHINGTON,DC 20307. RP ROSENBERG, ML (reprint author), UNIFORMED SERV UNIV HLTH SCI,DEPT NEUROL,4301 JONES BRIDGE RD,BETHESDA,MD 20814, USA. NR 11 TC 5 Z9 5 U1 0 U2 0 PU LITTLE BROWN CO PI BOSTON PA 34 BEACON STREET, BOSTON, MA 02108-1493 SN 0028-3878 J9 NEUROLOGY JI Neurology PD MAY PY 1991 VL 41 IS 5 BP 737 EP 739 PG 3 WC Clinical Neurology SC Neurosciences & Neurology GA FK928 UT WOS:A1991FK92800026 PM 1902918 ER PT J AU MAURER, PK ELLENBOGEN, RG ECKLUND, J SIMONDS, GR VANDAM, B ONDRA, SL AF MAURER, PK ELLENBOGEN, RG ECKLUND, J SIMONDS, GR VANDAM, B ONDRA, SL TI CERVICAL SPONDYLOTIC MYELOPATHY - TREATMENT WITH POSTERIOR DECOMPRESSION AND LUQUE RECTANGLE BONE FUSION SO NEUROSURGERY LA English DT Article DE CERVICAL MYELOPATHY; CERVICAL SPINE; CERVICAL SPONDYLOSIS; LAMINECTOMY; SPINAL STABILIZATION ID SURGICAL TREATMENT; NATURAL-HISTORY; SPINAL-CORD; STABILIZATION; COMPRESSION; DISEASE AB Cervical spondylotic myelopathy appears to result from a combination of factors. The two major components are 1) compressive forces resulting from narrowing of the spinal canal, and 2) dynamic forces owing to mobility of the cervical spine. There is substantial evidence to suggest that the repetitive trauma to the spinal cord that is sustained with movement in a spondylotic canal may be a major cause of progressive myelopathy. Utilization of extensive anterior procedures that remove the disease ventral features as well as eliminate the dynamic forces owing to the accompanying fusion have grown in popularity. Cervical laminectomy enlarges the spinal canal, but does not reduce the dynamic forces affecting the spinal cord, and may actually increase cervical mobility, leading to a perpetuation of the myelopathy. The authors propose the combination of posterior decompression and Luque rectangle bone fusion to deal with both the compressive and the dynamic factors that lead to cervical spondylotic myelopathy. Ten patients who had advanced myelopathy underwent the combined procedures. Nine of the 10 experienced significant neurological improvement, and the 10th has had no progression. The combination of posterior decompression and Luque rectangle bone fusion may offer a simple, safe, and effective alternative treatment for cervical spondylotic myelopathy. C1 WALTER REED ARMY MED CTR,DIV ORTHOPED SURG,WASHINGTON,DC 20307. RP MAURER, PK (reprint author), WALTER REED ARMY MED CTR,DIV NEUROSURG,NEUROSURG SERV 5C,WASHINGTON,DC 20307, USA. NR 32 TC 28 Z9 28 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0148-396X J9 NEUROSURGERY JI Neurosurgery PD MAY PY 1991 VL 28 IS 5 BP 680 EP 684 PG 5 WC Clinical Neurology; Surgery SC Neurosciences & Neurology; Surgery GA FJ828 UT WOS:A1991FJ82800007 PM 1876246 ER PT J AU CULBERTSON, RJ BURNS, FC FRANZEN, W LOWDER, LJ RICCA, JJ GONZALES, A AF CULBERTSON, RJ BURNS, FC FRANZEN, W LOWDER, LJ RICCA, JJ GONZALES, A TI PERFORMANCE EVALUATION OF ION-IMPLANTED CUTTING TOOLS AND DIES SO NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS LA English DT Article; Proceedings Paper CT 11TH INTERNATIONAL CONF ON THE APPLICATION OF ACCELERATORS IN RESEARCH AND INDUSTRY CY NOV 05-08, 1990 CL DENTON, TX ID WEAR AB The relative performance of ion-implanted and unimplanted machine tool taps, inserts, and punch-die sets was compared using blind tests. Performance of the tools, defined as the number of parts machined to within specifications, was evaluated under actual and simulated production conditions; relative performance was obtained by dividing the average performance of implanted tools by the average performance of unimplanted tools. The tools were implanted with a combination of 80 keV N+ and N2+. Implanted high speed steel taps exhibited performance by factors 1.5 to more than 4 as compared to unimplanted taps. Implanted TiN-coated metal cutting carbide inserts exhibited performance from factors of 2-4, and the performance factors of nitrogen-implanted punch-die sets ranged from 2.0 to 2.6. C1 CORPUS CHRISTI ARMY DEPOT,CORPUS CHRISTI,TX 78419. RP CULBERTSON, RJ (reprint author), USA,MAT TECHNOL LAB,WATERTOWN,MA 02172, USA. NR 12 TC 33 Z9 33 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0168-583X J9 NUCL INSTRUM METH B JI Nucl. Instrum. Methods Phys. Res. Sect. B-Beam Interact. Mater. Atoms PD MAY PY 1991 VL 56-7 BP 652 EP 655 DI 10.1016/0168-583X(91)96117-4 PN 1 PG 4 WC Instruments & Instrumentation; Nuclear Science & Technology; Physics, Atomic, Molecular & Chemical; Physics, Nuclear SC Instruments & Instrumentation; Nuclear Science & Technology; Physics GA FQ888 UT WOS:A1991FQ88800166 ER PT J AU THOMSON, GM AF THOMSON, GM TI X-RAY-FLUORESCENCE FOR HEAVY-METAL DUST ALARMS IN THE INDUSTRIAL WORKPLACE SO NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS LA English DT Article; Proceedings Paper CT 11TH INTERNATIONAL CONF ON THE APPLICATION OF ACCELERATORS IN RESEARCH AND INDUSTRY CY NOV 05-08, 1990 CL DENTON, TX AB A new X-ray fluorescence (XRF) device for the analysis of dense particle-bearing aerosols at the worksite has been developed. It provides values of the mass concentration M of each element Z > 22 held in aerosols typical of "smokestack" or acute occupational exposures (mg/m3-g/m3) on-site and in-time for corrective action before extensive harm to workers or the environment occurs. In operation the monitor irradiates the dispersed aerosol directly with the output of an interchangeable anode X-ray tube. The energy and number of returning XRF photons are used to identify the respective energies and abundances of the heavier elements contained within the aerosol. To date several specific apparatus configurations have been evaluated, mainly by comparing their relative sensitivities and minimum measurable mass concentrations as derived from data acquired with simulated target aerosols. These results are discussed along with the general principles behind the device, the target simulation, and the measurements themselves. RP THOMSON, GM (reprint author), USA,BALLIST RES LABS,ABERDEEN PROVING GROUND,MD 21005, USA. NR 2 TC 2 Z9 2 U1 0 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0168-583X J9 NUCL INSTRUM METH B JI Nucl. Instrum. Methods Phys. Res. Sect. B-Beam Interact. Mater. Atoms PD MAY PY 1991 VL 56-7 BP 730 EP 733 DI 10.1016/0168-583X(91)95014-5 PN 2 PG 4 WC Instruments & Instrumentation; Nuclear Science & Technology; Physics, Atomic, Molecular & Chemical; Physics, Nuclear SC Instruments & Instrumentation; Nuclear Science & Technology; Physics GA FQ890 UT WOS:A1991FQ89000014 ER PT J AU AGEE, FJ AF AGEE, FJ TI NEW CAPABILITIES FOR THE AURORA FLASH X-RAY MACHINE SO NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS LA English DT Article; Proceedings Paper CT 11TH INTERNATIONAL CONF ON THE APPLICATION OF ACCELERATORS IN RESEARCH AND INDUSTRY CY NOV 05-08, 1990 CL DENTON, TX ID BREMSSTRAHLUNG AB A series of recent upgrades enable the Aurora flash X-ray machine to provide a wide variety of different radiation pulses. The original design gives a single gamma-ray pulse with 50 ns risetime and 135 ns width that irradiates a volume of around 1 m3 with up to 50 krad (Si). The upgrades allow for two pulses with arbitrary separation in time, each with half the output. The pulse widths can be shortened to around 30 ns (with reduced energy), and the risetime can be reduced to 10 ns. These upgrades are discussed in some detail. Other upgrades are described elsewhere: the moderate energy bremsstrahlung option is described by J.A. Anderson et al. [Nucl. Instr. and Meth. B40/41 (1989) 1189]; the high power microwave option is described by G.A. Huttlin et al. [IEEE Trans. Plasma Sci. PS-18 (1990) 618 and other papers in this series]. RP AGEE, FJ (reprint author), USA,LAB COMMAND,HARRY DIAMOND LABS,ADELPHI,MD 20783, USA. NR 8 TC 3 Z9 3 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0168-583X J9 NUCL INSTRUM METH B JI Nucl. Instrum. Methods Phys. Res. Sect. B-Beam Interact. Mater. Atoms PD MAY PY 1991 VL 56-7 BP 1063 EP 1067 DI 10.1016/0168-583X(91)95097-W PN 2 PG 5 WC Instruments & Instrumentation; Nuclear Science & Technology; Physics, Atomic, Molecular & Chemical; Physics, Nuclear SC Instruments & Instrumentation; Nuclear Science & Technology; Physics GA FQ890 UT WOS:A1991FQ89000097 ER PT J AU RUFFIN, PB MO, G SUNG, CC AF RUFFIN, PB MO, G SUNG, CC TI WINDING TENSION AND TEMPERATURE-DEPENDENCE OF SIGNAL LOSSES IN A WOUND FIBER SO OPTICAL ENGINEERING LA English DT Article DE FIBER OPTICS, MICROBENDING LOSS; STRESS-INDUCED ABSORPTION AB The excess signal loss in precision-wound optical fiber is measured as a function of the winding tension and the environmental temperature. Since the heat treatment of the wound fiber reduces the signal loss, the residual loss is attributed to the bending loss mechanism caused by the crossovers. A theoretical model is constructed to relate the distortion of the fiber to that of the buffer and is expressed in terms of the winding tension. Various mechanisms for the enhanced distortion at low temperature in current literature are examined along with the experimental data. The calculation is compared with the data with quantitative agreement. C1 UNIV ALABAMA,DEPT PHYS,HUNTSVILLE,AL 35899. RP RUFFIN, PB (reprint author), USA,MISSILE COMMAND,CTR RD&E,REDSTONE ARSENAL,AL 35898, USA. NR 14 TC 0 Z9 0 U1 0 U2 0 PU SOC PHOTO-OPT INSTRUM ENG PI BELLINGHAM PA PO BOX 10, BELLINGHAM, WA 98227-0010 SN 0091-3286 J9 OPT ENG JI Opt. Eng. PD MAY PY 1991 VL 30 IS 5 BP 517 EP 523 DI 10.1117/12.55841 PG 7 WC Optics SC Optics GA FK496 UT WOS:A1991FK49600003 ER PT J AU BOREMAN, GD JAMES, AB COSTANZO, CR AF BOREMAN, GD JAMES, AB COSTANZO, CR TI SPATIAL HARMONIC DISTORTION - A TEST FOR FOCAL PLANE NONLINEARITY SO OPTICAL ENGINEERING LA English DT Article DE FOCAL PLANES; DETECTOR ARRAYS; CHARGE-COUPLED DEVICES; CHARGE-TRANSFER DEVICES; NONLINEARITY; NONUNIFORMITY; HARMONIC DISTORTION; FLAT-FIELD TEST ID NONUNIFORMITY AB A new measurement technique for focal plane linearity was investigated experimentally. The spatial harmonic distortion test consists of projecting spatial sine waves of irradiance onto a focal plane by means of a Young's fringe technique. If the detectors in the array have a linear responsivity, a sinusoidal input waveform is mapped to a sinusoidal output. However, if the detectors in the array have a nonlinear responsivity (i.e., saturation), then the output waveform will exhibit harmonic distortion. When the Fourier transform of the array data is taken, the content at the second and third harmonics of the original sine-wave spatial frequency indicates the amount of nonlinearity in the aggregate array response. Measurement results are included for two focal planes: a vidicon tube camera and a solid-state charge-injection device (CID) camera. The minimum harmonic distortion measured was 3%. The sensitivity of this test is limited ultimately by the amount of spatial nonuniformity. Numerical and analytical models are given that indicate the minimum detectable harmonic distortion is in the range of a few percent. This test also allows measurement of the spatial-frequency dependence of the nonlinearity, a quantity that is not accessible with the usual flat-field techniques for linearity assessment. C1 USA,CTR NIGHT VIS & ELECTROOPT,DIV INFRARED TECHNOL,FT BELVOIR,VA 22060. RP BOREMAN, GD (reprint author), UNIV CENT FLORIDA,CTR RES ELECTROOPT & LASERS,DEPT ELECT ENGN,ORLANDO,FL 32816, USA. NR 8 TC 2 Z9 2 U1 0 U2 0 PU SOC PHOTO-OPT INSTRUM ENG PI BELLINGHAM PA PO BOX 10, BELLINGHAM, WA 98227-0010 SN 0091-3286 J9 OPT ENG JI Opt. Eng. PD MAY PY 1991 VL 30 IS 5 BP 609 EP 614 DI 10.1117/12.55832 PG 6 WC Optics SC Optics GA FK496 UT WOS:A1991FK49600014 ER PT J AU DOWLING, JP SCULLY, MO DEMARTINI, F AF DOWLING, JP SCULLY, MO DEMARTINI, F TI RADIATION-PATTERN OF A CLASSICAL DIPOLE IN A CAVITY SO OPTICS COMMUNICATIONS LA English DT Article ID INHIBITED SPONTANEOUS EMISSION; QUANTUM ELECTRODYNAMICS; MICROSCOPIC CAVITY; ATOM; DECAY AB We present a classical model for the radiation patterns of atomic dipoles confined in a cavity which makes use of the image method and antenna theory. C1 USA,MISSILE COMMAND,OPT GRP,RES DIRECTORATE,REDSTONE ARSENAL,AL 35398. UNIV NEW MEXICO,CTR ADV STUDIES,ALBUQUERQUE,NM 87131. UNIV NEW MEXICO,DEPT PHYS & ASTRON,ALBUQUERQUE,NM 87131. UNIV ROME LA SAPIENZA,DIPARTMENTO FIS,I-00185 ROME,ITALY. RP DOWLING, JP (reprint author), MAX PLANCK INST QUANTUM OPT,W-8046 GARCHING,GERMANY. RI DOWLING, JONATHAN/L-2749-2013 NR 25 TC 46 Z9 46 U1 0 U2 8 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0030-4018 J9 OPT COMMUN JI Opt. Commun. PD MAY 1 PY 1991 VL 82 IS 5-6 BP 415 EP 419 DI 10.1016/0030-4018(91)90351-D PG 5 WC Optics SC Optics GA FM519 UT WOS:A1991FM51900001 ER PT J AU NACY, CA MEIEROVICS, AI BELOSEVIC, M GREEN, SJ AF NACY, CA MEIEROVICS, AI BELOSEVIC, M GREEN, SJ TI TUMOR-NECROSIS-FACTOR-ALPHA - CENTRAL REGULATORY CYTOKINE IN THE INDUCTION OF MACROPHAGE ANTIMICROBIAL ACTIVITIES SO PATHOBIOLOGY LA English DT Article; Proceedings Paper CT 1990 ANNUAL CONF OF THE UPPER RHINE UNIVERSITIES CY SEP 06-08, 1990 CL FREIBURG, FED REP GER DE CYTOKINES; LEISHMANIA; MACROPHAGES; RESISTANCE; INFECTION; INTRACELLULAR KILLING; ACTIVATION ID L-ARGININE; ACTIVATED MACROPHAGES; INTERFERON-GAMMA; CUTANEOUS LEISHMANIASIS; NITRIC-OXIDE; FACTOR TNF; IFN-GAMMA; LYMPHOKINES; RESISTANCE; INFECTION AB Expression of activated macrophage resistance to infection requires the cooperative interaction of interferon-gamma (IFN-gamma) and either interleukin-2 (IL-2), interleukin-4 or granulocyte/macrophage-colony-stimulating factor: no single cytokine is effective. For IFN-gamma and IL-2, the effector activity can be suppressed by the presence of anti-tumor necrosis factor-alpha (TNF-alpha) antibodies in the reaction mixture. IFN-gamma and IL-2, only in combination, induce TNF-alpha-specific mRNA and secretion of this cytokine by macrophages. Development of intracellular killing activity by activated macrophages also requires the autocrine effects of TNF-alpha. IFN-gamma provides the first signal for the production of nitric oxide (NO), the effector molecule for intracellular destruction of parasites. When IFN-gamma-treated cells are infected with pathogens, they are stimulated to make TNF-alpha. Expression of intracellular killing, as well as production of NO, is inhibited by anti-TNF-alpha antibody. C1 WALTER REED ARMY MED CTR,DIV CELLULAR IMMUNOL,WASHINGTON,DC 20307. RI Belosevic, Miodrag/C-6729-2008 OI Belosevic, Miodrag/0000-0002-6412-8236 NR 16 TC 66 Z9 67 U1 0 U2 0 PU KARGER PI BASEL PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND SN 1015-2008 J9 PATHOBIOLOGY JI Pathobiology PD MAY-JUN PY 1991 VL 59 IS 3 BP 182 EP 184 DI 10.1159/000163640 PG 3 WC Cell Biology; Pathology SC Cell Biology; Pathology GA FP846 UT WOS:A1991FP84600012 PM 1909141 ER PT J AU WISWELL, TE HACHEY, WE AF WISWELL, TE HACHEY, WE TI MULTIPLE SITE BLOOD CULTURES IN THE INITIAL EVALUATION FOR NEONATAL SEPSIS DURING THE 1ST WEEK OF LIFE SO PEDIATRIC INFECTIOUS DISEASE JOURNAL LA English DT Article DE BLOOD CULTURE; SEPSIS NEONATORUM; BACTEREMIA ID DIAGNOSIS AB We present the first investigation that examines the usefulness of multiple site blood cultures in the initial evaluation for neonatal sepsis during the first week of life. Two sets of blood cultures (1 aerobic and 1 anaerobic bottle/set; BACTEC(R), NR 6A/7A) from different sites were obtained from 460 inborn infants who were evaluated for possible sepsis. From 0.5 to 1 ml of blood was inoculated into each blood culture bottle. In 18 infants the use of multiple site blood cultures yielded important information. In 8 of these neonates bacteremia was confirmed whereas in 10 cases contamination from skin flora was documented. We could identify no instances in which the delay in antibiotic therapy while the second set of blood cultures was obtained contributed to an adverse outcome. We conclude that multiple site blood cultures are useful in the initial evaluation for suspected sepsis during the first week of life. RP WISWELL, TE (reprint author), WALTER REED ARMY MED CTR,DEPT PEDIAT,NEONATOL SERV,WASHINGTON,DC 20307, USA. NR 20 TC 22 Z9 23 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0891-3668 J9 PEDIATR INFECT DIS J JI Pediatr. Infect. Dis. J. PD MAY PY 1991 VL 10 IS 5 BP 365 EP 369 DI 10.1097/00006454-199105000-00004 PG 5 WC Immunology; Infectious Diseases; Pediatrics SC Immunology; Infectious Diseases; Pediatrics GA FL892 UT WOS:A1991FL89200004 PM 2067886 ER PT J AU KIRBY, WC AF KIRBY, WC TI TURNER SYNDROME - REPLY SO PEDIATRICS LA English DT Letter RP KIRBY, WC (reprint author), WALTER REED ARMY MED CTR,WASHINGTON,DC 20307, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD, ELK GROVE VILLAGE, IL 60007-1098 SN 0031-4005 J9 PEDIATRICS JI Pediatrics PD MAY PY 1991 VL 87 IS 5 BP 745 EP 745 PG 1 WC Pediatrics SC Pediatrics GA FL115 UT WOS:A1991FL11500035 ER PT J AU ROSCELLI, JD AF ROSCELLI, JD TI URINARY-TRACT INFECTIONS SO PEDIATRICS LA English DT Letter ID INFANTS RP ROSCELLI, JD (reprint author), TRIPLER ARMY MED CTR,PEDIAT NEPHROL,HONOLULU,HI 96859, USA. NR 3 TC 0 Z9 0 U1 0 U2 0 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD, ELK GROVE VILLAGE, IL 60007-1098 SN 0031-4005 J9 PEDIATRICS JI Pediatrics PD MAY PY 1991 VL 87 IS 5 BP 745 EP 746 PG 2 WC Pediatrics SC Pediatrics GA FL115 UT WOS:A1991FL11500036 PM 2020532 ER PT J AU BABKOFF, H CASPY, T MIKULINCER, M SING, HC AF BABKOFF, H CASPY, T MIKULINCER, M SING, HC TI MONOTONIC AND RHYTHMIC INFLUENCES - A CHALLENGE FOR SLEEP-DEPRIVATION RESEARCH SO PSYCHOLOGICAL BULLETIN LA English DT Review ID TERM RECOGNITION MEMORY; COGNITIVE PERFORMANCE; SUSTAINED OPERATIONS; MILITARY PERFORMANCE; CIRCADIAN-RHYTHMS; TASK; TIME; WORK; VIGILANCE; RECOVERY AB There are both monotonic and rhythmic factors in the patterns of change seen in physiological, psychological, and performance variables during sleep deprivation. These monotonic and rhythmic factors can be orthogonal, or they may interact with each other, with various task variables, or both. The importance of separating the rhythmic from the monotonic factors and of elucidating their interactions is discussed. Experimental methods and types of analysis appropriate to evaluating these factors are examined, with special emphasis on the complex demodulation time series analysis applied to group or individual subject data. The discussion is accompanied by data illustrations. It is suggested that sleep deprivation research should be designed so as to generate physiological and behavioral data that include information on both monotonic and rhythmic factors, the nature and extent of their interaction, and how they interrelate with systematically manipulated independent variables. C1 WALTER REED ARMY MED CTR,DEPT BEHAV BIOL,WASHINGTON,DC 20307. RP BABKOFF, H (reprint author), BAR ILAN UNIV,DEPT PSYCHOL,IL-52100 RAMAT GAN,ISRAEL. NR 128 TC 37 Z9 43 U1 1 U2 3 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 SN 0033-2909 J9 PSYCHOL BULL JI Psychol. Bull. PD MAY PY 1991 VL 109 IS 3 BP 411 EP 428 DI 10.1037/0033-2909.109.3.411 PG 18 WC Psychology; Psychology, Multidisciplinary SC Psychology GA FK217 UT WOS:A1991FK21700005 PM 2062980 ER PT J AU CELMINS, A AF CELMINS, A TI A PRACTICAL APPROACH TO NONLINEAR FUZZY REGRESSION SO SIAM JOURNAL ON SCIENTIFIC AND STATISTICAL COMPUTING LA English DT Article DE FUZZY NONLINEAR MODELS; FUZZY DATA; FUZZY REGRESSION; LEAST SQUARES; CONICAL MEMBERSHIP FUNCTION ID LINEAR-REGRESSION; MODEL AB This paper presents a new method of mathematical modeling in an uncertain environment. The uncertainties of data and model are treated using concepts of fuzzy set theory. The model fitting principle is the minimization of a least squares objective function. A practical modeling procedure is obtained by restricting the type of data and parameter fuzziness to conical membership functions. Under this restriction, the model fitting problem can be solved numerically with the aid of any least squares software for regression with implicit constraint equations. The paper contains a short discussion of the geometry of fuzzy point and function spaces with conical membership functions, and illustrates the application of fuzzy regression with an example from terminal ballistics. RP CELMINS, A (reprint author), USA,BALLIST RES LABS,ABERDEEN PROVING GROUND,MD 21005, USA. NR 16 TC 27 Z9 28 U1 0 U2 1 PU SIAM PUBLICATIONS PI PHILADELPHIA PA 3600 UNIV CITY SCIENCE CENTER PH#382-9800, PHILADELPHIA, PA 19104-2688 SN 0196-5204 J9 SIAM J SCI STAT COMP PD MAY PY 1991 VL 12 IS 3 BP 521 EP 546 PG 26 WC Mathematics, Applied SC Mathematics GA FH213 UT WOS:A1991FH21300004 ER PT J AU PARRAVICINI, GP RESCA, L GRAFT, RD LOHRMANN, DJ AF PARRAVICINI, GP RESCA, L GRAFT, RD LOHRMANN, DJ TI INTERVALLEY INTERFERENCE AND LATTICE-RELAXATION IN DX CENTERS SO SOLID STATE COMMUNICATIONS LA English DT Article ID SHALLOW-DEEP INSTABILITIES; DOPED ALXGA1-XAS X=0; IMPURITY LEVELS; MULTIVALLEY SEMICONDUCTORS; COMPREHENSIVE ANALYSIS; RECURSION METHOD; GREEN-FUNCTION; GAAS; GA1-XALXAS; RESONANCE AB We present a model of the DX center in Ga(1-x)Al(x)As linking lattice relaxation to electronic intervalley interference among conduction-band L-minima. This accounts for both the electronic characteristics of the DX center and the barriers for electron emission/recapture, as functions of the alloy concentration. Accurate calculations (initially on the unrelaxed electronic system) with the recursion method are suggested, along with experiments on peculiar Ga(1-x)Al(x)As quantum wells and superlattices; these may reveal suppression and regeneration of the DX center by varying the Ga(1-x)Al(x)As well thickness, hence interchanging the GAMMA- and L-states through quantum confinement. C1 DIPARTIMENTO FIS A VOLTA,I-27100 PAVIA,ITALY. CATHOLIC UNIV AMER,DEPT PHYS,WASHINGTON,DC 20064. USA,CTR NIGHT VIS & ELECTROOPT,FT BELVOIR,VA 22060. NR 23 TC 4 Z9 4 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0038-1098 J9 SOLID STATE COMMUN JI Solid State Commun. PD MAY PY 1991 VL 78 IS 7 BP 655 EP 657 PG 3 WC Physics, Condensed Matter SC Physics GA FP664 UT WOS:A1991FP66400017 ER PT J AU TEJAISAVADHARM, P KEERATITHAKUL, D WATT, G WEBSTER, HK EDSTEIN, MD AF TEJAISAVADHARM, P KEERATITHAKUL, D WATT, G WEBSTER, HK EDSTEIN, MD TI MEASUREMENT OF CIPROFLOXACIN IN HUMAN PLASMA, WHOLE-BLOOD, AND ERYTHROCYTES BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY SO THERAPEUTIC DRUG MONITORING LA English DT Article DE CIPROFLOXACIN; FLUOROQUINOLONE; MALARIA; HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY ID SERUM; URINE; PHARMACOKINETICS; METABOLITES; MALARIA AB A simple, rapid, and accurate high-performance liquid chromatographic method using fluorescence detection is described for the measurement of ciprofloxacin in plasma, whole blood, and erythrocytes. Ciprofloxacin and the internal standard difloxacin were separated on a mu-Bondapak C18 column (30 cm x 3.9 mm inside diameter, 10-mu-m particle size), using a mobile phase of 0.1 M phosphate buffer (pH 2.5):acetonitrile (75:25, vol/vol). The retention times were 5.1 min for ciprofloxacin and 7.9 min for difloxacin. The compounds were extracted from the three biological fluids using protein precipitation followed by a single-step liquid-liquid extraction. The assay is precise, with interassay coefficients of variation of less-than-or-equal-to 9.1% and an accuracy of less-than-or-equal-to 7.4% at 0.5 and 5.0-mu-g/ml (n = 5). The mean extraction recoveries of ciprofloxacin in plasma, whole blood, and erythrocytes were 84.4, 63.9, and 48.0%. The limit of detection for ciprofloxacin is 25 ng/ml. Ciprofloxacin concentrations in the three biological fluids were measured in patients with uncomplicated falciparum malaria to demonstrate the application of the method. C1 ARMED FORCES RES INST MED SCI,DEPT IMMUNOL & BIOCHEM,315-6 RAJAVITHI RD,BANGKOK 10400,THAILAND. ARMED FORCES RES INST MED SCI,DEPT MED,BANGKOK 10400,THAILAND. NR 15 TC 14 Z9 14 U1 0 U2 4 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0163-4356 J9 THER DRUG MONIT JI Ther. Drug Monit. PD MAY PY 1991 VL 13 IS 3 BP 263 EP 267 DI 10.1097/00007691-199105000-00014 PG 5 WC Medical Laboratory Technology; Pharmacology & Pharmacy; Toxicology SC Medical Laboratory Technology; Pharmacology & Pharmacy; Toxicology GA FU322 UT WOS:A1991FU32200014 PM 1926283 ER PT J AU WISLER, JA DULANEY, MD PELLICORE, LS LENZ, DE AF WISLER, JA DULANEY, MD PELLICORE, LS LENZ, DE TI TRANSPORT OF CYANIDE INTO GUINEA-PIG CARDIAC MITOCHONDRIA SO TOXICOLOGY LETTERS LA English DT Article DE CYANIDE; ANION TRANSPORT; ACTIVE TRANSPORT; CARDIAC MITOCHONDRIA; CYANIDE TOXICITY; GUINEA PIG ID RABBIT AB The transport of cyanide (CN) into cells has been presumed to be by passive diffusion. Recently, there have been reports that CN, in the form of an anion, may enter the cell by active or facilitated transport. To characterize the mechanism(s) and kinetics of CN movement across the cell membrane, we measured the rate of (CN)-C-14 (Na salt) uptake into guinea-pig mitochondria. Initial velocities of CN movement into mitochondria were determined at time points ranging from 10-100 msec and at CN concentrations ranging from 1-mu-M-10 mM using a rapid filtration device. A Hofstee plot of the data suggests that an active or facilitated transport predominates at lower CN concentrations (< 10-mu-M), whereas passive diffusion of CN predominates at higher CN concentrations. The kinetic constants for the active phase transport were J(max) = 0.9 pmol/ms and K(t) = 14-mu-M. These results suggest that a large portion of CN movement across the cell membrane is due to an active or facilitated transport phenomenon. C1 USA,MED RES INST CHEM DEF,BIOCHEM PHARMACOL BRANCH,ABERDEEN PROVING GROUND,MD 21010. NR 17 TC 3 Z9 3 U1 0 U2 3 PU ELSEVIER SCI IRELAND LTD PI CLARE PA CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE, IRELAND SN 0378-4274 J9 TOXICOL LETT JI Toxicol. Lett. PD MAY PY 1991 VL 56 IS 3 BP 275 EP 281 DI 10.1016/0378-4274(91)90156-Z PG 7 WC Toxicology SC Toxicology GA FN017 UT WOS:A1991FN01700004 PM 2035175 ER PT J AU SMALL, GW KALTENBACH, TF KROUTIL, RT AF SMALL, GW KALTENBACH, TF KROUTIL, RT TI RAPID SIGNAL-PROCESSING TECHNIQUES FOR FOURIER-TRANSFORM INFRARED REMOTE-SENSING SO TRAC-TRENDS IN ANALYTICAL CHEMISTRY LA English DT Article ID PATTERN-RECOGNITION; INTERFEROGRAMS AB A description is given of digital filtering and pattern recognition methods that implement an automated detection algorithm for passive Fourier transform infrared (FTIR) remote sensing data. The digital filtering step allows spectral information to be extracted from the interferogram data without the use of the Fourier transform. The detection is performed with only a 76-point segment of the FTIR interferogram, thereby simplifying the data collection requirements of the spectrometer. C1 USA,CTR CHEM RES DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010. RP SMALL, GW (reprint author), UNIV IOWA,DEPT CHEM,IOWA CITY,IA 52242, USA. NR 13 TC 15 Z9 15 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0165-9936 J9 TRAC-TREND ANAL CHEM JI Trac-Trends Anal. Chem. PD MAY PY 1991 VL 10 IS 5 BP 149 EP 155 DI 10.1016/0165-9936(91)85117-A PG 7 WC Chemistry, Analytical SC Chemistry GA FP147 UT WOS:A1991FP14700008 ER PT J AU SHERWOOD, JA OSTER, CN ADOYOADOYO, M BEIER, JC GACHIHI, GS NYAKUNDI, PM BALLOU, WR BRANDLINGBENNETT, AD SCHWARTZ, IK WERE, JBO WIRTZ, RA SCHNEIDER, I ROBERTS, CR YOUNG, JF GROSS, M CHULAY, JD AF SHERWOOD, JA OSTER, CN ADOYOADOYO, M BEIER, JC GACHIHI, GS NYAKUNDI, PM BALLOU, WR BRANDLINGBENNETT, AD SCHWARTZ, IK WERE, JBO WIRTZ, RA SCHNEIDER, I ROBERTS, CR YOUNG, JF GROSS, M CHULAY, JD TI SAFETY AND IMMUNOGENICITY OF A PLASMODIUM-FALCIPARUM SPOROZOITE VACCINE - BOOSTING OF ANTIBODY-RESPONSE IN A POPULATION WITH PRIOR NATURAL EXPOSURE TO MALARIA SO TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID NATURALLY ACQUIRED ANTIBODIES; T-CELL EPITOPE; CIRCUMSPOROZOITE PROTEIN; ESCHERICHIA-COLI; SURFACE-ANTIGEN; EFFICACY; IMMUNITY; MICE AB Recombinant sporozoite vaccine or placebo were administered once to 25 volunteers from an area endemic for malaria. Antibody to R32tet32 rose in 9 of 15 receiving vaccine and remained elevated in 6 for 6 months. Mean absorbance increase was 0.43 +/- 0.40 with vaccine, 0.01 +/- 0.23 with placebo, and 0.72 +/- 0.19 in responders. Six non-responders had significantly lower pre-immunization levels (0.07 +/- 0.05) than responders (0.39 +/- 0.25). There was an association between an increase in immunofluorescence (n = 4) and an increase in absorbence (n = 9) among vaccine recipients (n = 15). Vaccine-induced increase in antibody to natural circumsporozoite antigen was indicated by increases in immunofluorescence and by increases in circumsporozoite precipitation score in 2 of the 5 responders with highest antibody increase measured by enzyme-linked immunosorbent assay. Response to subunit sporozoite vaccine paralleled response to prior natural sporozoite exposure and was significant and prolonged in a population with prior natural exposure to malaria. C1 KENYA GOVT MED RES CTR,CLIN RES CTR,NAIROBI,KENYA. KENYA MED RES,BIOMED SCI RES CTR,NAIROBI,KENYA. WALTER REED ARMY MED CTR,DEPT IMMUNOL,DIV COMMUNICABLE DIS & IMMUNOL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT ENTOMOL,WASHINGTON,DC 20307. CTR DIS CONTROL,DIV PARASIT DIS,ATLANTA,GA 30333. SK&F LABS,KING OF PRUSSIA,PA. RP SHERWOOD, JA (reprint author), USA,MED RES UNIT,BOX 30137,NAIROBI,KENYA. NR 21 TC 16 Z9 16 U1 0 U2 0 PU ROYAL SOC TROPICAL MEDICINE PI LONDON PA MANSON HOUSE 26 PORTLAND PLACE, LONDON, ENGLAND W1N 4EY SN 0035-9203 J9 T ROY SOC TROP MED H JI Trans. Roy. Soc. Trop. Med. Hyg. PD MAY-JUN PY 1991 VL 85 IS 3 BP 336 EP 340 DI 10.1016/0035-9203(91)90281-3 PG 5 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA FU718 UT WOS:A1991FU71800005 PM 1949134 ER PT J AU BOWMAN, JS JAFFERS, G WAYMACK, JP AF BOWMAN, JS JAFFERS, G WAYMACK, JP TI REUTILIZATION OF A TRANSPLANTED KIDNEY - A CASE-REPORT SO TRANSPLANTATION LA English DT Note C1 USA,INST SURG RES,DEPT SURG TRANSPLANTAT,JOINT MIL MED COMMAND SAN ANTONIO,SAN ANTONIO,TX 78236. NR 3 TC 4 Z9 5 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0041-1337 J9 TRANSPLANTATION JI Transplantation PD MAY PY 1991 VL 51 IS 5 BP 1124 EP 1125 PG 2 WC Immunology; Surgery; Transplantation SC Immunology; Surgery; Transplantation GA FM344 UT WOS:A1991FM34400038 PM 1851583 ER PT J AU VENKATESAN, M FERNANDEZPRADA, C BUYSSE, JM FORMAL, SB HALE, TL AF VENKATESAN, M FERNANDEZPRADA, C BUYSSE, JM FORMAL, SB HALE, TL TI VIRULENCE PHENOTYPE AND GENETIC-CHARACTERISTICS OF THE T32-ISTRATI SHIGELLA-FLEXNERI-2A VACCINE STRAIN SO VACCINE LA English DT Article DE SHIGELLA-FLEXNERI; T32-ISTRATI; VADIZEN; ATTENUATION ID ENTEROINVASIVE ESCHERICHIA-COLI; SHIGELLA-FLEXNERI 2A; CONGO RED BINDING; PLASMID GENES; CELL INVASION; IDENTIFICATION; PROTEIN; SEQUENCE; LOCUS; ANTIGENS AB The T32-ISTRATI strain, which has been used as an oral attenuated Shigella flexneri 2a vaccine, has lost the invasive phenotype due to a spontaneous deletion in the shigella virulence plasmid. This deletion has eliminated three plasmid loci (ipaBCDA, invA and virG) that are necessary for production of a positive Sereny test by Shigella species. Virulence in the Sereny test was reconstituted in the T32-ISTRATI strain by the conjugal transfer of an intact 140 MDa virulence plasmid from S. flexneri 5. The T32-ISTRATI vaccine is safe when given orally in multiple doses of 50-100 x 10(9) organisms, and both homologous and heterologous protection has been reported in large Romanian and Chinese field trials. Although the protective antigen(s) in this vaccine have not been identified, the potential use of non-invasive plasmid deletion mutants as living shigella vaccines is illustrated by the T32-ISTRATI vaccine. C1 WALTER REED ARMY MED CTR,DEPT BACTERIAL IMMUNOL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT ENTER INFECT,WASHINGTON,DC 20307. NR 29 TC 25 Z9 29 U1 0 U2 1 PU BUTTERWORTH-HEINEMANN LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB SN 0264-410X J9 VACCINE JI Vaccine PD MAY PY 1991 VL 9 IS 5 BP 358 EP 363 DI 10.1016/0264-410X(91)90064-D PG 6 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA FH523 UT WOS:A1991FH52300014 PM 1872021 ER PT J AU RONISH, RH DINIEGA, BM KELLEY, PW SJOGREN, MH ARDAY, DR ARONSON, NE HOKE, CH PETRUCCELLI, BP AF RONISH, RH DINIEGA, BM KELLEY, PW SJOGREN, MH ARDAY, DR ARONSON, NE HOKE, CH PETRUCCELLI, BP TI IMMUNOGENICITY ACHIEVED BY THE INTRADERMAL HEPATITIS-B VACCINATION PROGRAM FOR US-ARMY SOLDIERS IN KOREA SO VACCINE LA English DT Article DE HEPATITIS-B; INTRADERMAL VACCINATION; IMMUNOGENICITY; MILITARY ID CELL RABIES VACCINE; HOMOSEXUAL MEN; VIRUS-VACCINE; EFFICACY; IMMUNIZATION; TRIAL AB Hepatitis B virus (HBV) infections are a significant threat to the 30 000 US Army soldiers stationed in South Korea. Hepatitis B surface antigen carrier rates in some Korean populations may run as high as 15%, and HBV incidence estimates for US soldiers in Korea have ranged from 0.6 to 6% per year. In response to this threat, on 1 October 1986 the US Army instituted a mandatory three-dose (0, 30-60, and 60 + days), 0.1 ml per dose, intradermal (i.d.) immunization regimen for all soldiers bound for permanent assignments in Korea. Although shown to be immunogenic in experimental studies, the i.d. route had never been attempted on as large a scale as in this operational setting. During September 1987, an evaluation of programme compliance and immune response was conducted. For those who received three doses according to schedule, antibody response was similar to that reported by previous controlled trials that used the i.d. approach. The three-dose i.d. series appeared to provide protective antibody levels in at least 67% of soldiers, but, consistent with previous trials, antibody levels were approximately one-half those obtained following intramuscular vaccination. We conclude that, as a cost-reduction strategy, wide-scale use of intradermal hepatitis B vaccine may be useful in situations characterized by short-term increased HBV infection risk. C1 WALTER REED ARMY MED CTR,DEPT MED,WASHINGTON,DC 20307. SECOND INFANTRY DIV,DIV SURGEONS OFF,TONGDUCHON,PEOPLES R CHINA. RP RONISH, RH (reprint author), WALTER REED ARMY MED CTR,DIV PREVENT MED,EPIDEMIOL CONSULTANT SERV,WASHINGTON,DC 20307, USA. NR 17 TC 7 Z9 7 U1 0 U2 1 PU BUTTERWORTH-HEINEMANN LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB SN 0264-410X J9 VACCINE JI Vaccine PD MAY PY 1991 VL 9 IS 5 BP 364 EP 368 DI 10.1016/0264-410X(91)90065-E PG 5 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA FH523 UT WOS:A1991FH52300015 PM 1872022 ER PT J AU WASSEF, NM MATYAS, GR ALVING, CR AF WASSEF, NM MATYAS, GR ALVING, CR TI COMPLEMENT-DEPENDENT PHAGOCYTOSIS OF LIPOSOMES BY MACROPHAGES - SUPPRESSIVE EFFECTS OF STEALTH LIPIDS SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS LA English DT Article ID MEDIATED ENDOCYTOSIS; IMMUNE DAMAGE; GANGLIOSIDES; ANTIBODIES RP WASSEF, NM (reprint author), WALTER REED ARMY MED CTR,DEPT MEMBRANE BIOCHEM,WASHINGTON,DC 20307, USA. NR 24 TC 41 Z9 41 U1 0 U2 1 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0006-291X J9 BIOCHEM BIOPH RES CO JI Biochem. Biophys. Res. Commun. PD APR 30 PY 1991 VL 176 IS 2 BP 866 EP 874 DI 10.1016/S0006-291X(05)80266-9 PG 9 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA FK023 UT WOS:A1991FK02300048 PM 2025298 ER PT J AU RICKMAN, LS GORDON, DM WISTAR, R KRZYCH, U GROSS, M HOLLINGDALE, MR EGAN, JE CHULAY, JD HOFFMAN, SL AF RICKMAN, LS GORDON, DM WISTAR, R KRZYCH, U GROSS, M HOLLINGDALE, MR EGAN, JE CHULAY, JD HOFFMAN, SL TI USE OF ADJUVANT CONTAINING MYCOBACTERIAL CELL-WALL SKELETON, MONOPHOSPHORYL LIPID-A, AND SQUALANE IN MALARIA CIRCUMSPOROZOITE PROTEIN VACCINE SO LANCET LA English DT Article ID PLASMODIUM-FALCIPARUM; PHASE-I; MURABUTIDE AB Human immune responses to modern synthetic and recombinant peptide vaccines administered with the standard adjuvant, aluminum hydroxide, tend to be poor, hence the search for better adjuvants. Antibody responses to a Plasmodium falciparum circumsporozoite (CS) protein vaccine, R32NS1(81), administered with an adjuvant containing cell-wall skeleton of mycobacteria and monophosphoryl lipid A in squalane (MPL/CWS) have been compared to responses to the same immunogen administered with aluminum hydroxide. 2 weeks after the third dose the following indices were greater in the 5 patients who received MPL/CWS than in controls (p < 0.05): the geometric mean concentration (2.0 vs 25.4-mu-g/ml) and avidity index of antibodies to the P falciparum CS protein by ELISA, the geometric mean titre to P falciparum sporozoites by IFAT (1/115 vs 1/1600), and the geometric mean inhibition of sporozoite invasion of hepatoma cells in vitro (37.6 vs 90.3%). For R32NS1(81) MPL/CWS is superior to aluminum hydroxide as an adjuvant, and the data support the evaluation of this complex as an adjuvant for other vaccines. C1 USN, MED RES INST,DEPT INFECT DIS,MALARIA PROGRAM, 12300 WASHINGTON AVE, ROCKVILLE, MD 20852 USA. BIOMED RES INST, ROCKVILLE, MD USA. SMITHKLINE BEECHAM, DEPT MOLEC GENET, KING OF PRUSSIA, PA USA. WALTER REED ARMY MED CTR, DEPT IMMUNOL, WASHINGTON, DC 20307 USA. NATL NAVAL MED CTR, DIV INFECT DIS, BETHESDA, MD 20814 USA. NR 18 TC 65 Z9 65 U1 0 U2 0 PU LANCET LTD PI LONDON PA 42 BEDFORD SQUARE, LONDON, ENGLAND WC1B 3SL SN 0140-6736 J9 LANCET JI Lancet PD APR 27 PY 1991 VL 337 IS 8748 BP 998 EP 1001 DI 10.1016/0140-6736(91)92659-P PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA FJ135 UT WOS:A1991FJ13500003 PM 1673211 ER PT J AU HOFFMAN, SL NUSSENZWEIG, V SADOFF, JC NUSSENZWEIG, RS AF HOFFMAN, SL NUSSENZWEIG, V SADOFF, JC NUSSENZWEIG, RS TI PROGRESS TOWARD MALARIA PREERYTHROCYTIC VACCINES SO SCIENCE LA English DT Editorial Material ID CIRCUMSPOROZOITE PROTEIN; EPITOPE C1 NYU MED CTR,DEPT PATHOL,NEW YORK,NY 10016. NYU MED CTR,KAPLAN CANC CTR,NEW YORK,NY 10016. WALTER REED ARMY MED CTR,DIV COMMUNICABLE DIS & IMMUNOL,WASHINGTON,DC 20307. NYU,SCH MED,DEPT MED & MOLEC PARASITOL,NEW YORK,NY 10010. RP HOFFMAN, SL (reprint author), USN,MED RES INST,BETHESDA,MD 20889, USA. NR 29 TC 38 Z9 38 U1 0 U2 1 PU AMER ASSOC ADVANCEMENT SCIENCE PI WASHINGTON PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 SN 0036-8075 J9 SCIENCE JI Science PD APR 26 PY 1991 VL 252 IS 5005 BP 520 EP 521 DI 10.1126/science.2020852 PG 2 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA FJ127 UT WOS:A1991FJ12700034 PM 2020852 ER PT J AU ROBERTS, WL DOCTOR, BP FOSTER, JD ROSENBERRY, TL AF ROBERTS, WL DOCTOR, BP FOSTER, JD ROSENBERRY, TL TI BOVINE BRAIN ACETYLCHOLINESTERASE PRIMARY SEQUENCE INVOLVED IN INTERSUBUNIT DISULFIDE LINKAGES SO JOURNAL OF BIOLOGICAL CHEMISTRY LA English DT Article ID HUMAN-ERYTHROCYTE ACETYLCHOLINESTERASE; TORPEDO ELECTRIC ORGAN; STRUCTURAL CHARACTERIZATION; MOLECULAR-FORMS; CHOLINESTERASE; PROTEINS; IDENTIFICATION; DOMAIN; ANCHOR; BONDS AB Three distinct classes of membrane-bound acetylcholinesterases (AChEs) have been identified. A12 AChE is composed of 12 catalytic subunits that are linked to noncatalytic collagen-like subunits through intersubunit disulfide bonds. G2 AChE is localized in membranes by a glycoinositol phospholipid covalently linked to the C-terminal amino acid. Brain G4 AChE involves two catalytic subunits linked by a direct intersubunit disulfide bond while the other two are disulfide-linked to a membrane-binding 20-kDa noncatalytic subunit. Molecular cloning studies have so far failed to find evidence of more than one AChE gene in any organism although alternative splicing of torpedo AChE mRNA results in different C-terminal sequences for the A12 and G2 AChE forms. Support for a single bovine AChE gene is provided in this report by amino acid sequencing of the N-terminal domains from the G2 erythrocyte, G4 fetal serum, and G4 brain AChE. Comparison of the 38-amino acid sequences reveals virtually complete identity among the three AChE forms. Additional extensive identity between the fetal serum and brain AChEs was demonstrated by sequencing several brain AChE peptides isolated by high performance liquid chromatography after trypsin digestion of nitro-cellulose blots of brain AChE catalytic subunits. Cysteines involved in intersubunit disulfide linkages in brain AChE were reduced selectively with dithiothreitol in the absence of denaturants and radioalkylated with iodoacetamide. The observed sequence of the major radiolabeled tryptic peptide was C*SDL, where C* was the radioalkylated cysteine residue. This sequence is precisely the same as that observed at the C terminus of fetal bovine serum AChE and shows close homology to the C-terminal sequence of torpedo A12 AChE. We conclude that the mammalian brain G4 AChEs utilize the same exon splicing pattern as the A12 AChEs and that factors other than the primary sequence of the AChE catalytic subunits dictate assembly with either the collagen-like or the 20-kDa noncatalytic subunits. C1 CASE WESTERN RESERVE UNIV,DEPT PHARMACOL,CLEVELAND,OH 44106. WALTER REED ARMY MED CTR,DIV BIOCHEM,WASHINGTON,DC 20307. FU NINDS NIH HHS [NS16577] NR 30 TC 50 Z9 50 U1 0 U2 0 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0021-9258 J9 J BIOL CHEM JI J. Biol. Chem. PD APR 25 PY 1991 VL 266 IS 12 BP 7481 EP 7487 PG 7 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA FJ342 UT WOS:A1991FJ34200027 PM 2019579 ER PT J AU KROBER, MS STRACENER, CE BASS, JW AF KROBER, MS STRACENER, CE BASS, JW TI DECREASED MEASLES ANTIBODY-RESPONSE AFTER MEASLES-MUMPS-RUBELLA VACCINE IN INFANTS WITH COLDS SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Note ID INTERFERON-PRODUCTION AB We examined the possibility that the common cold or afebrile upper respiratory tract infection might interfere with successful immunization in children who receive standard measles-mumps-rubella vaccine. Infants 15 to 18 months of age presenting at our well-child clinics for routine examination and immunizations were divided into two groups. Those infants with a history and physical findings of upper respiratory tract infection were compared with healthy control group infants who did not have upper respiratory tract infections, and who did not have a history of upper respiratory tract infection symptoms within the previous month. Both groups were studied for their serologic response to measles-mumps-rubella vaccination. Prevaccination serum samples were obtained prior to vaccine administration and postvaccination serum samples were obtained 6 to 8 weeks later. Measles antibody was measured in these serum samples by an indirect fluorescein-tagged antibody test. Ten (21%) of 47 infants with colds failed to develop measles antibody, while only one (2%) of 51 well infants failed to develop antibody. We conclude that infants with colds have a significant seroconversion failure rate associated with measles vaccine administration and that this may be the cause of some primary measles vaccine failures. C1 TRIPLER ARMY MED CTR,DEPT PEDIAT,HONOLULU,HI 96859. RP KROBER, MS (reprint author), MADIGAN ARMY MED CTR,DEPT PEDIAT,BOX 295,TACOMA,WA 98431, USA. NR 18 TC 38 Z9 39 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD APR 24 PY 1991 VL 265 IS 16 BP 2095 EP 2096 DI 10.1001/jama.265.16.2095 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA FG907 UT WOS:A1991FG90700027 PM 2013930 ER PT J AU BRUCE, CW STROMBERG, TF GURTON, KP MOZER, JB AF BRUCE, CW STROMBERG, TF GURTON, KP MOZER, JB TI TRANS-SPECTRAL ABSORPTION AND SCATTERING OF ELECTROMAGNETIC-RADIATION BY DIESEL SOOT SO APPLIED OPTICS LA English DT Article ID OPTICAL-PROPERTIES; PARTICLES; SMOKE; AGGREGATION; DIMENSION; DIFFUSION; AEROSOLS; CARBON AB The mass density normalized absorption and total scattering coefficients have been measured using in situ techniques at selected wavelengths from the visible to approximately 1 cm for soot generated by the open combustion of diesel fuel. Particle morphologies are complex although similar to those of soots of other hydrocarbons and methods of generation. An ellipsoidal model has been applied as an approximation to the often multiconnected, chainlike aerosol and then compared with the measured results. The experimental results show an approximate (lambda)-1 dependence over more than five decades of wavelength data. There is only general agreement with the simplified calculations in this feature as well as in the magnitude. C1 NEW MEXICO STATE UNIV,DEPT PHYS,LAS CRUCES,NM 88003. RP BRUCE, CW (reprint author), USA,ATMOSPHER SCI LAB,WHITE SANDS MISSILE RANGE,NM 88002, USA. NR 40 TC 49 Z9 49 U1 2 U2 6 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0003-6935 J9 APPL OPTICS JI Appl. Optics PD APR 20 PY 1991 VL 30 IS 12 BP 1537 EP 1546 PG 10 WC Optics SC Optics GA FJ906 UT WOS:A1991FJ90600017 PM 20700316 ER PT J AU CARR, FE GALLOWAY, RJ REID, AH KASEEM, LL DHILLON, G FEIN, HG SMALLRIDGE, RC AF CARR, FE GALLOWAY, RJ REID, AH KASEEM, LL DHILLON, G FEIN, HG SMALLRIDGE, RC TI THYROTROPIN-RELEASING-HORMONE REGULATION OF THYROTROPIN BETA-SUBUNIT GENE-EXPRESSION INVOLVES INTRACELLULAR CALCIUM AND PROTEIN-KINASE-C SO BIOCHEMISTRY LA English DT Article ID RAT PITUITARY-CELLS; EPIDERMAL GROWTH-FACTOR; MESSENGER-RNA SEQUENCES; PROLACTIN GENE; PHORBOL ESTER; GH3 CELLS; TUMOR CELLS; PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE; TRANSCRIPTION FACTOR; FLANKING SEQUENCES AB Our previous studies demonstrated TRH stimulation of TSH-beta-gene expression in rat pituitary cell cultures and GH3 tumor cells in a transient expression assay. To begin to characterize the gene-proximal elements of the pathways involved in TRH stimulation of TSH-beta-gene transcription, we examined the effects of factors that increase intracellular calcium concentration, [Ca2+]i, or activate protein kinase C on TSH-beta-promoter activity in transfected GH3 cells. TPA, a tumor-promoting phorbol ester, stimulated a dose-dependent increase in TSH-beta-promoter activity at 8 h similar to TRH (2-3-fold). TPA did stimulate protein kinase C activation without [Ca2+] mobilization. The calcium ionophore ionomycin increased cytoplasmic free [Ca2+] by stimulating both calcium influx and release from internal stores without affecting protein kinase C. Ionomycin also stimulated a dose-dependent increase (2-fold) in TSH-beta-promoter activity at 8 h. However, the voltage-dependent Ca2+ channel agonist Bay K 8644, which increased influx of extracellular calcium, had little or no effect on TSH-beta-gene expression until 48 h (5-fold). Similar effects on prolactin/mRNA levels were observed in these cells. Effects of these factors were not additive, suggesting a common pathway(s) to stimulate gene expression. Inhibition of intracellular calcium mobilization by treatment with 8-(N,N-diethylamino)octyl 3,4,5-trimethoxybenzoate (TMB-8) inhibited ionomycin effects on gene expression without affecting phorbol ester activity, and, conversely, inhibition of protein kinase C activity by 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine dihydrochloride (H-7) or TPA desensitization blocked TPA effects without affecting ionomycin activity. However, TRH stimulation of TSH-beta-gene expression was inhibited by decreasing both calcium mobilization and protein kinase C activity. These effects were mediated through the same 180 bp DNA sequence in the 5'-flanking region of the rat TSH-beta-subunit gene. These results strongly suggest that both protein kinase C and [Ca2+] mobilization are important factors in mediating TRH-induced TSH-beta-gene expression. C1 WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT CLIN PHYSIOL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT MED NEUROSCI,WASHINGTON,DC 20307. NR 67 TC 19 Z9 19 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0006-2960 J9 BIOCHEMISTRY-US JI Biochemistry PD APR 16 PY 1991 VL 30 IS 15 BP 3721 EP 3728 DI 10.1021/bi00229a019 PG 8 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA FG730 UT WOS:A1991FG73000019 PM 1707668 ER PT J AU BIRENZVIGE, A KRISHNAN, PN FAMINI, GR STURDIVAN, LM MORRIS, RE AF BIRENZVIGE, A KRISHNAN, PN FAMINI, GR STURDIVAN, LM MORRIS, RE TI TEACHING OLD DOGS NEW TRICKS - APPLYING NEW STATISTICAL TECHNIQUES TO MOLECULAR-ORBITAL CALCULATIONS SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,CTR CHEM RES & DEV,ABERDEEN PROVING GROUND,MD 21010. COPPIN STATE COLL,DEPT NAT SCI,BALTIMORE,MD 21216. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 14 PY 1991 VL 201 BP 8 EP COMP PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA FG893 UT WOS:A1991FG89301372 ER PT J AU MAYER, JM GREENBERGER, M STOTE, RE WRIGHT, JR RESLEWIC, PA KAPLAN, DL AF MAYER, JM GREENBERGER, M STOTE, RE WRIGHT, JR RESLEWIC, PA KAPLAN, DL TI BIODEGRADATION METHODOLOGY AND DEGRADATION KINETICS OF POLYMER-FILMS SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,CTR RES DEV & ENGN,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 14 PY 1991 VL 201 BP 9 EP BIOT PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA FG893 UT WOS:A1991FG89300424 ER PT J AU FAMINI, GR KRISHNAN, PN MORRIS, RE BIRENZVIGE, A AF FAMINI, GR KRISHNAN, PN MORRIS, RE BIRENZVIGE, A TI ROTATIONAL BARRIERS IN POLYMERS USING SEMIEMPIRICAL MOLECULAR-ORBITAL THEORY SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,CTR DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010. COPPIN STATE COLL,DEPT NAT SCI,BALTIMORE,MD 21216. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 14 PY 1991 VL 201 BP 13 EP POLY PN 2 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA FG894 UT WOS:A1991FG89400829 ER PT J AU BRUCCATO, C WONG, S KAPLAN, DL GROSS, RA AF BRUCCATO, C WONG, S KAPLAN, DL GROSS, RA TI STUDIES ON A POLY(BETA-HYDROXYALKANOATE) DEPOLYMERASE ENZYME FROM PENICILLIUM-FUNICULOSUM SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,NATICK RD&E CTR,NATICK,MA 01760. UNIV LOWELL,DEPT CHEM,LOWELL,MA 01854. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 14 PY 1991 VL 201 BP 23 EP BIOT PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA FG893 UT WOS:A1991FG89300438 ER PT J AU JALALIHERAVI, M ZUTAUT, SE MCMANUS, SP MCDONALD, JK AF JALALIHERAVI, M ZUTAUT, SE MCMANUS, SP MCDONALD, JK TI THEORETICAL TREATMENT OF THE TOPOCHEMICAL POLYMERIZATION OF DIACETYLENES SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 UNIV ALABAMA,DEPT CHEM,HUNTSVILLE,AL 35899. USA,MISSILE RES & DEV COMMAND,RES DIRECTORATE,REDSTONE ARSENAL,AL 35809. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 14 PY 1991 VL 201 BP 23 EP POLY PN 2 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA FG894 UT WOS:A1991FG89400839 ER PT J AU GIANNOS, SA SHAH, D KAPLAN, DL MEYER, J MCCARTHY, SP GROSS, RA AF GIANNOS, SA SHAH, D KAPLAN, DL MEYER, J MCCARTHY, SP GROSS, RA TI POLY(GLUTAMIC ACID) OBTAINED FROM BACTERIAL FERMENTATION SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,NATICK RD&E CTR,NATICK,MA 01760. UNIV LOWELL,DEPT CHEM,LOWELL,MA 01854. UNIV LOWELL,DEPT PLAST ENGN,LOWELL,MA 01854. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 14 PY 1991 VL 201 BP 24 EP BIOT PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA FG893 UT WOS:A1991FG89300439 ER PT J AU KIM, DY RATTO, J BLUMSTEIN, RB AF KIM, DY RATTO, J BLUMSTEIN, RB TI PHASE-BEHAVIOR OF CHITOSAN-NYLON4 BLENDS - A DSC INVESTIGATION SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 UNIV LOWELL,DEPT CHEM,POLYMER SCI PROGRAM,LOWELL,MA 01850. USA,CTR RES DEV & ENVIRONM,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 14 PY 1991 VL 201 BP 40 EP POLY PN 2 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA FG894 UT WOS:A1991FG89400856 ER PT J AU HUDSON, SM WEI, YC MEYER, JM KAPLAN, DL AF HUDSON, SM WEI, YC MEYER, JM KAPLAN, DL TI THE CROSS-LINKING OF CHITOSAN FIBERS AND FILMS SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 N CAROLINA STATE UNIV,FIBER & POLYMER SCI PROGRAM,RALEIGH,NC 27695. USA,NATICK RES CTR,BIOTECHNOL BRANCH,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 14 PY 1991 VL 201 BP 53 EP CELL PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA FG893 UT WOS:A1991FG89300654 ER PT J AU MUNAVALLI, S ROSSMAN, DI ROHRBAUGH, DK FERGUSON, CP AF MUNAVALLI, S ROSSMAN, DI ROHRBAUGH, DK FERGUSON, CP TI GRIGNARD-REAGENT FACILITATED SYNTHESIS OF UNSYMMETRICAL DISULFIDES SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,CRDEC,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 14 PY 1991 VL 201 BP 53 EP ORGN PN 2 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA FG894 UT WOS:A1991FG89400156 ER PT J AU MUNAVALLI, S ROSSMAN, DI ROHRBAUGH, DK FERGUSON, CP AF MUNAVALLI, S ROSSMAN, DI ROHRBAUGH, DK FERGUSON, CP TI UNSYMMETRICAL DISULFIDES VIA THIAPHILIC ADDITION-ELIMINATION SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,CRDEC,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 14 PY 1991 VL 201 BP 54 EP ORGN PN 2 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA FG894 UT WOS:A1991FG89400157 ER PT J AU HONG, SS AMEMYA, Y VENKATRAMAN, BV PATIL, PN SHAMS, G ROMSTEDT, K FELLER, D HSU, FL MILLER, DD AF HONG, SS AMEMYA, Y VENKATRAMAN, BV PATIL, PN SHAMS, G ROMSTEDT, K FELLER, D HSU, FL MILLER, DD TI SYNTHESIS AND BIOLOGICAL-ACTIVITIES NAPHTHAZOLINE AND MEDETOMIDINE ANALOGS SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 OHIO STATE UNIV,COLL PHARM,DIV MED CHEM & PHARMACOGNOSY,COLUMBUS,OH 43210. OHIO STATE UNIV,COLL PHARM,DIV PHARMACOL,COLUMBUS,OH 43210. USA,ABERDEEN PROVING GROUND,MD 21021. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 14 PY 1991 VL 201 BP 58 EP MEDI PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA FG893 UT WOS:A1991FG89302473 ER PT J AU HSU, FL SZAFRANIEC, LL BEAUDRY, WT BISHOP, JE BANKS, HD AF HSU, FL SZAFRANIEC, LL BEAUDRY, WT BISHOP, JE BANKS, HD TI SYNTHETIC STUDIES OF 3-FLUOROFENTANYL SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,CTR CHEM RES DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 1 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 14 PY 1991 VL 201 BP 58 EP ORGN PN 2 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA FG894 UT WOS:A1991FG89400161 ER PT J AU ROGERS, KR ANIS, N VALDES, JJ ELDEFRAWI, ME AF ROGERS, KR ANIS, N VALDES, JJ ELDEFRAWI, ME TI FIBER OPTIC BIOSENSORS FOR RAPID DETECTION OF ANTICHOLINESTERASES SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 UNIV MARYLAND,SCH MED,DEPT PHARMACOL & EXPTL THERAPEUT,BALTIMORE,MD 21201. USA,CTR RES DEV & ENGN,DIV BIOTECHNOL,EDGEWOOD,MD. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 14 PY 1991 VL 201 BP 65 EP AGRO PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA FG893 UT WOS:A1991FG89300144 ER PT J AU MACKAY, RA GOODE, MT STOPA, PJ ZULICH, AW AF MACKAY, RA GOODE, MT STOPA, PJ ZULICH, AW TI LIGHT ADDRESSABLE POTENTIOMETRIC SENSOR BASED DETECTION OF TOXINS AND PATHOGENS SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,CTR CHEM RES DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 1 Z9 1 U1 2 U2 2 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 14 PY 1991 VL 201 BP 69 EP ENVR PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA FG893 UT WOS:A1991FG89301452 ER PT J AU BHATTACHARJEE, AK SADOFF, JC COLLINS, H CROSS, AS ALI, HK BIEBER, MM NELSON, NHT AF BHATTACHARJEE, AK SADOFF, JC COLLINS, H CROSS, AS ALI, HK BIEBER, MM NELSON, NHT TI SYNTHESIS AND CHARACTERIZATION OF GENTIOBIOSE HEPTAACETATE CONJUGATE VACCINES THAT PRODUCE ENDOTOXIN NEUTRALIZING ANTIBODIES SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 STANFORD UNIV,MED CTR,SCH MED,CANC BIOL RES LAB,STANFORD,CA 94305. WALTER REED ARMY MED CTR,DEPT BACTERIAL DIS,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 14 PY 1991 VL 201 BP 73 EP CARB PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA FG893 UT WOS:A1991FG89300596 ER PT J AU PAGANO, S KRISHNAN, PN BIRENZVIGE, A NESBITT, F AF PAGANO, S KRISHNAN, PN BIRENZVIGE, A NESBITT, F TI XPS ANALYSIS OF METALLIC IMPREGNANTS ON ACTIVATED-CHARCOAL SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 NASA,GODDARD SPACE FLIGHT CTR,GREENBELT,MD 20771. USA,CTR CHEM RES DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010. COPPIN STATE COLL,DEPT NAT SCI,BALTIMORE,MD 21216. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 14 PY 1991 VL 201 BP 89 EP COLL PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA FG893 UT WOS:A1991FG89301110 ER PT J AU KEITH, JA STOCKWELL, SA FLETCHER, MR NAPIER, K DONNLEY, TS KAPLAN, DL AF KEITH, JA STOCKWELL, SA FLETCHER, MR NAPIER, K DONNLEY, TS KAPLAN, DL TI CHARACTERIZATION OF MYTILUS-EDULIS MATRIX PROTEINS AND THE INFLUENCE OF TEMPERATURE ON CRYSTALLIZATION OF CACO3 UNDER MONOLAYERS SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,CTR RES DEV & ENGN,NATICK,MA 01760. USA,MAT TECHNOL LABS,WATERTOWN,MA 02172. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 14 PY 1991 VL 201 BP 92 EP IEC PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA FG893 UT WOS:A1991FG89301843 ER PT J AU AVERBACH, BL CONDON, MJ NAKASHIMA, M AF AVERBACH, BL CONDON, MJ NAKASHIMA, M TI CHITOSAN-COPPER COMPLEXES SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,CTR RD&E,SOLDIER SCI DIRECTORATE,NATICK,MA 01760. MIT,DEPT MAT SCI,CAMBRIDGE,MA 02139. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 14 PY 1991 VL 201 BP 105 EP IEC PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA FG893 UT WOS:A1991FG89301856 ER PT J AU DALVIE, D SUNDBERG, RJ CORDERO, J MUSALLAM, HA AF DALVIE, D SUNDBERG, RJ CORDERO, J MUSALLAM, HA TI IMIDAZOLIUM, PYRIDINIUM AND IMIDAZO[1,2-A]PYRIDINIUM SALTS AS REVERSIBLE INHIBITORS OF ACETYLCHOLINESTERASE SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 UNIV VIRGINIA,DEPT CHEM,CHARLOTTESVILLE,VA 22901. WALTER REED ARMY MED CTR,DEPT MED CHEM,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 14 PY 1991 VL 201 BP 108 EP MEDI PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA FG893 UT WOS:A1991FG89302523 ER PT J AU MAYER, JM GREENBERGER, M STOTE, RE BALL, DH KAPLAN, DL AF MAYER, JM GREENBERGER, M STOTE, RE BALL, DH KAPLAN, DL TI PRODUCTION, DERIVATIZATION AND EVALUATION OF BIODEGRADABLE POLYMER-FILMS SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,CTR RES DEV & ENGN,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 14 PY 1991 VL 201 BP 141 EP IEC PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA FG893 UT WOS:A1991FG89301889 ER PT J AU DURST, HD CAMERON, KP ANTHONY, JS FORD, MS FREUDENBERGER, S AF DURST, HD CAMERON, KP ANTHONY, JS FORD, MS FREUDENBERGER, S TI POTENTIAL USE OF A MOBILE MASS-SPECTROMETER IN POLLUTION PREVENTION SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,CTR CHEM RES DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010. SCI & TECHNOL CORP,HAMPTON,VA 23666. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 14 PY 1991 VL 201 BP 147 EP ENVR PN 1 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA FG893 UT WOS:A1991FG89301529 ER PT J AU VANDERHOFF, JW PARK, JM SEGALL, I HONG, SH AF VANDERHOFF, JW PARK, JM SEGALL, I HONG, SH TI SMALL-PARTICLE-SIZE POLY(ALKYLAMINOALKYL METHACRYLATE-CO-ALKYL METHACRYLATE) LATEXES SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 LEHIGH UNIV,INST EMULS POLYMERS,BETHLEHEM,PA 18015. LEHIGH UNIV,DEPT CHEM,BETHLEHEM,PA 18015. USA,CTR CHEM RES DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 14 PY 1991 VL 201 BP 161 EP PMSE PN 2 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA FG894 UT WOS:A1991FG89401327 ER PT J AU SAMUELSON, LA MILLER, P GALOTTI, DM MARX, KA KUMAR, J TRIPATHY, SK KAPLAN, DL AF SAMUELSON, LA MILLER, P GALOTTI, DM MARX, KA KUMAR, J TRIPATHY, SK KAPLAN, DL TI SURFACE SPECIFIC RECOGNITION OF FLUORESCENT CONJUGATED STREPTAVIDIN-PHYCOERYTHRIN PROTEINS ONTO BIOTIN LIPID LB MONOLAYER FILMS SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,NATICK RES & DEV LABS,BIOTECHNOL BRANCH,NATICK,MA 01760. UNIV LOWELL,DEPT CHEM,LOWELL,MA 01854. UNIV LOWELL,DEPT PHYS,LOWELL,MA 01854. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 14 PY 1991 VL 201 BP 162 EP POLY PN 2 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA FG894 UT WOS:A1991FG89400970 ER PT J AU MUNAVALLI, S ROSSMAN, DI AARON, HS FERGUSON, CP ROHRBAUGH, DK AF MUNAVALLI, S ROSSMAN, DI AARON, HS FERGUSON, CP ROHRBAUGH, DK TI A CONVENIENT METHOD FOR THE INTRODUCTION OF THE TRIFLUOROMETHYLTHIO GROUP SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 USA,CRDEC,SMCCR RSC O,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 14 PY 1991 VL 201 BP 167 EP ORGN PN 2 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA FG894 UT WOS:A1991FG89400269 ER PT J AU BRUNO, F AKKARA, JA SAMUELSON, LA MANDAL, BK KAPLAN, DL MARX, KA TRIPATHY, SK AF BRUNO, F AKKARA, JA SAMUELSON, LA MANDAL, BK KAPLAN, DL MARX, KA TRIPATHY, SK TI ENZYME CATALYZED POLYMERIZATION OF PHENOL DERIVATIVES ON A LANGMUIR-BLODGETT TROUGH SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 UNIV LOWELL,DEPT CHEM,LOWELL,MA 01854. USA,NATICK RES & DEV LABS,BIOTECHNOL BRANCH,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 14 PY 1991 VL 201 BP 186 EP POLY PN 2 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA FG894 UT WOS:A1991FG89400994 ER PT J AU VANDERHOFF, JW PARK, JM SEGALL, I HONG, SH AF VANDERHOFF, JW PARK, JM SEGALL, I HONG, SH TI EMULSION COPOLYMERIZATION OF POLY(ALKYLAMINOALKYL METHACRYLATE-COALKYL METHACRYLATE) SO ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY LA English DT Meeting Abstract C1 LEHIGH UNIV,INST EMULS POLYMERS,BETHLEHEM,PA 18015. LEHIGH UNIV,DEPT CHEM,BETHLEHEM,PA 18015. USA,CTR CHEM RES DEV & ENGN,RES DIRECTORATE,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0065-7727 J9 ABSTR PAP AM CHEM S JI Abstr. Pap. Am. Chem. Soc. PD APR 14 PY 1991 VL 201 BP 317 EP POLY PN 2 PG 0 WC Chemistry, Multidisciplinary SC Chemistry GA FG894 UT WOS:A1991FG89401125 ER PT J AU GREGORY, DA LOUDIN, JA KIRSCH, JC TAM, EC YU, FTS AF GREGORY, DA LOUDIN, JA KIRSCH, JC TAM, EC YU, FTS TI USING THE HYBRID MODULATING PROPERTIES OF LIQUID-CRYSTAL TELEVISION SO APPLIED OPTICS LA English DT Article ID PHASE-ONLY MODULATION; CORRELATOR AB The phase modulating capabilities of a commercially available liquid crystal television (LCTV) have been investigated and applied to the joint transform optical correlator architecture. Operating the LCTV in a phase modulating mode requires a much smaller coherent light source while still producing a good joint transform power spectrum and good correlation signals. C1 PENN STATE UNIV,UNIVERSITY PK,PA 16802. RP GREGORY, DA (reprint author), USA,MISSILE COMMAND,REDSTONE ARSENAL,AL 35898, USA. NR 11 TC 42 Z9 42 U1 0 U2 0 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0003-6935 J9 APPL OPTICS JI Appl. Optics PD APR 10 PY 1991 VL 30 IS 11 BP 1374 EP 1378 PG 5 WC Optics SC Optics GA FH779 UT WOS:A1991FH77900013 PM 20700293 ER PT J AU CHOI, KK DUTTA, M MOERKIRK, RP KUAN, CH IAFRATE, GJ AF CHOI, KK DUTTA, M MOERKIRK, RP KUAN, CH IAFRATE, GJ TI APPLICATION OF SUPERLATTICE BANDPASS-FILTERS IN 10 MU-M INFRARED DETECTION SO APPLIED PHYSICS LETTERS LA English DT Article ID ELECTRON AB Recently, experimental evidence has revealed that the energy distribution of the dark current in a typical multiple quantum well GaAs infrared detector is extremely broad, in contrast to the narrowly distributed photocurrent. In this letter, we present the current transfer ratio of an infrared hot-electron transistor with a superlattice collector filter. From the current transfer characteristics, we demonstrate that the superlattice is able to collect electrons with specific energy against a broad background. The energy filtering characteristics can be attributed to the underlying band structure of the superlattice. When the filter is applied to infrared radiation detection, the detectivity of the transistor is improved. C1 PRINCETON UNIV,DEPT ELECT ENGN,PRINCETON,NJ 08544. USA,RES OFF,RES TRIANGLE PK,NC 27709. RP CHOI, KK (reprint author), USA,ELECTR TECHNOL & DEVICES LAB,FT MONMOUTH,NJ 07703, USA. RI Choi, Kwong-Kit/K-9205-2013 NR 9 TC 12 Z9 12 U1 0 U2 1 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD APR 8 PY 1991 VL 58 IS 14 BP 1533 EP 1535 DI 10.1063/1.105169 PG 3 WC Physics, Applied SC Physics GA FF231 UT WOS:A1991FF23100027 ER PT J AU MCCANN, UD RICAURTE, GA AF MCCANN, UD RICAURTE, GA TI MAJOR METABOLITES OF (+/-)3,4-METHYLENEDIOXYAMPHETAMINE (MDA) DO NOT MEDIATE ITS TOXIC EFFECTS ON BRAIN-SEROTONIN NEURONS SO BRAIN RESEARCH LA English DT Note DE SEROTONIN; NEUROTOXICITY; METHYLENEDIOXYAMPHETAMINE; AMPHETAMINE; ALPHA-METHYLDOPA ID RAT-BRAIN; 3,4-METHYLENEDIOXYMETHAMPHETAMINE MDMA; PARA-CHLOROAMPHETAMINE; TERMINALS; METHAMPHETAMINE; AMPHETAMINE; DOPAMINE; METHYLENEDIOXYMETHAMPHETAMINE; 5,6-DIHYDROXYTRYPTAMINE; 6-HYDROXYDOPAMINE AB The two major metabolites of (+/-)3,4-methylenedioxyamphetamine (MDA), alpha-methyldopamine (alpha-MeDA) and 3-O-methyl-alpha-methyldopamine (3-O-Me-alpha-MeDA), were administered to rats intracerebroventricularly and into brain parenchyma. In addition, their precursors, (alpha-MeDOPA and 3-O-Me-alpha-MeDOPA, respectively) were administered systemically, individually and in combination. None of these treatments produced a lasting depletion of brain serotonin (5-HT). These findings suggest that neither of MDA's major metabolites mediate its toxic effects on 5-HT neurons and that either a minor metabolite is responsible or that alternate mechanisms are involved. C1 JOHNS HOPKINS MED INST,DEPT NEUROL,BALTIMORE,MD 21224. WALTER REED ARMY MED CTR,DEPT BEHAV BIOL,WASHINGTON,DC 20307. NR 30 TC 42 Z9 42 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0006-8993 J9 BRAIN RES JI Brain Res. PD APR 5 PY 1991 VL 545 IS 1-2 BP 279 EP 282 DI 10.1016/0006-8993(91)91297-E PG 4 WC Neurosciences SC Neurosciences & Neurology GA FJ128 UT WOS:A1991FJ12800036 PM 1860050 ER PT J AU MCQUAID, MJ MIZIOLEK, AW SAUSA, RC MERROW, CN AF MCQUAID, MJ MIZIOLEK, AW SAUSA, RC MERROW, CN TI PHOTODISSOCIATION OF DIMETHYLNITRAMINE AT 248 NM SO JOURNAL OF PHYSICAL CHEMISTRY LA English DT Article ID PREDISSOCIATIVE LIFETIMES; LASER PYROLYSIS; GAS-PHASE; 266 NM; OH; STATE; OD AB The production of OH A2-SIGMA+, OH X2-PI(i), NO2 A2B2, NO2 X2A1, and NO X2-PI following dimethylnitramine (DMNA) photolysis at 248 nm has been investigated by using laser-induced fluorescence and emission spectroscopies. NO2 A2B2, NO2 X2A1, and OH X2-PI(i) are formed via monophotonic, unimolecular pathways. The quantum yields for NO2 X2A1 and OH X2-PI(i), production are estimated to be 0.15 and 0.004, respectively. The unimolecular production of NO X2-PI (upsilon" = 0) was not observed, implying its quantum yield is < 0.001. OH A2-SIGMA+ is formed via a two-photon, unimolecular process. These results are compared with previous studies investigating the thermal and photochemical decomposition of DMNA. C1 USA,BALLIST RES LAB,SLCBR-IB-I,ABERDEEN PROVING GROUND,MD 21005. USA,CTR CHEM RES DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010. NR 29 TC 22 Z9 22 U1 2 U2 4 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0022-3654 J9 J PHYS CHEM-US JI J. Phys. Chem. PD APR 4 PY 1991 VL 95 IS 7 BP 2713 EP 2718 DI 10.1021/j100160a018 PG 6 WC Chemistry, Physical SC Chemistry GA FE953 UT WOS:A1991FE95300018 ER PT J AU MCNEIL, JG BRUNDAGE, JF GARDNER, LI WANN, ZF RENZULLO, PO REDFIELD, RR BURKE, DS MILLER, RN AF MCNEIL, JG BRUNDAGE, JF GARDNER, LI WANN, ZF RENZULLO, PO REDFIELD, RR BURKE, DS MILLER, RN TI TRENDS OF HIV SEROCONVERSION AMONG YOUNG-ADULTS IN THE UNITED-STATES-ARMY, 1985 TO 1989 SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Article ID HTLV-III; INFECTION; AIDS; MEN; ANTIBODIES; TESTS AB Because soldiers in the US Army are recurrently tested for the presence of antibody to the human immunodeficiency virus (HIV), HIV seroconversion rates can be directly measured. From November 1985 through October 1989, 429 HIV seroconversions were detected among 718 780 soldiers who contributed 1 088 447 person-years of follow-up time (HIV seroconversion rate, 0.39 per 1000 person-years). Period-specific seroconversion rates declined significantly, from 0.49 per 1000 person-years (November 1985 through October 1987) to 0.33 per 1000 person-years (November 1987 through October 1988) to 0.29 per 1000 person-years (November 1988 through October 1989). The HIV seroconversion risk among active-duty soldiers was significantly associated with race/ethnic group, age, gender, and marital status. Based on these trends, we estimate that approximately 220 soldiers (95% confidence interval, 160 to 297 soldiers) were infected with HIV during 1989 and 1990, with potentially fewer in future years. C1 SRA TECHNOL,ALEXANDRIA,VA. WALTER REED ARMY MED CTR,DIV RETROVIROL,WASHINGTON,DC 20307. RP MCNEIL, JG (reprint author), WALTER REED ARMY MED CTR,DEPT EPIDEMIOL,DIV PREVENT MED,WASHINGTON,DC 20307, USA. NR 29 TC 20 Z9 20 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD APR 3 PY 1991 VL 265 IS 13 BP 1709 EP 1714 DI 10.1001/jama.265.13.1709 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA FD659 UT WOS:A1991FD65900027 PM 2002572 ER PT J AU SANDLER, S AF SANDLER, S TI MILITARY PLANNING FOR THE DEFENSE OF THE UNITED-KINGDOM, 1814-1870 - PARTRIDGE,MS SO AMERICAN HISTORICAL REVIEW LA English DT Book Review RP SANDLER, S (reprint author), JOHN F KENNEDY SPECIAL WARFARE CTR & SCH,FT BRAGG,NC, USA. NR 1 TC 0 Z9 0 U1 1 U2 1 PU AMER HISTORICAL REVIEW PI WASHINGTON PA 400 A ST SE, WASHINGTON, DC 20003 SN 0002-8762 J9 AM HIST REV JI Am. Hist. Rev. PD APR PY 1991 VL 96 IS 2 BP 513 EP 513 DI 10.2307/2163279 PG 1 WC History SC History GA FK335 UT WOS:A1991FK33500067 ER PT J AU HOUSE, JM AF HOUSE, JM TI CONSCRIPTS AND DESERTERS - THE ARMY AND FRENCH SOCIETY DURING THE REVOLUTION AND EMPIRE - FORREST,A SO AMERICAN HISTORICAL REVIEW LA English DT Book Review RP HOUSE, JM (reprint author), USA,CTR MIL HIST,WASHINGTON,DC 20310, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU AMER HISTORICAL REVIEW PI WASHINGTON PA 400 A ST SE, WASHINGTON, DC 20003 SN 0002-8762 J9 AM HIST REV JI Am. Hist. Rev. PD APR PY 1991 VL 96 IS 2 BP 529 EP 529 DI 10.2307/2163304 PG 1 WC History SC History GA FK335 UT WOS:A1991FK33500092 ER PT J AU CANCIO, LC AF CANCIO, LC TI STRESS AND TRANCE IN FREEFALL PARACHUTING - A PILOT-STUDY SO AMERICAN JOURNAL OF CLINICAL HYPNOSIS LA English DT Article ID MULTIPLE PERSONALITIES; SKIN-CONDUCTANCE; SELF-HYPNOSIS; EEG-ALPHA; HYPNOTIZABILITY; DISORDER; IMAGERY; ENHANCEMENT; PERFORMANCE RP CANCIO, LC (reprint author), USA,DIV AIRBORNE 82D,1ST BRIGADE,FT BRAGG,NC 28307, USA. NR 45 TC 9 Z9 11 U1 1 U2 3 PU AMER SOC CLIN HYPNOSIS PI DES PLAINES PA 2200 EAST DEVON AVE SUITE 291, DES PLAINES, IL 60018 SN 0002-9157 J9 AM J CLIN HYPN JI Am. J. Clin. Hypn. PD APR PY 1991 VL 33 IS 4 BP 225 EP 234 PG 10 WC Psychology, Clinical SC Psychology GA FE140 UT WOS:A1991FE14000002 PM 2024614 ER PT J AU WEISS, JC DOUGHTY, RA LAMPE, R AF WEISS, JC DOUGHTY, RA LAMPE, R TI THE PEDIATRIC PROGRAM DIRECTOR - AN ANALYSIS OF THE ROLE AND ITS PROBLEMS SO AMERICAN JOURNAL OF DISEASES OF CHILDREN LA English DT Article AB A questionnaire designed to elicit information about the work environment, knowledge, and stresses of pediatric residency program directors was mailed to the 235 member programs of the Association of Pediatric Program Directors (APPD). At the time that the 187 respondents (80% return rate) assumed responsibility for their training programs, many rated their knowledge of various aspects of residency program administration as "poor." The respondents indicated that a lack of time, the pressures of too many other academic responsibilities, and a fear of not "filling" all positions in the National Intern Matching Program created much personal stress. Most program directors felt that educational conferences designed to teach educational methods, and administrative skills, and provide technical information knowledge necessary for residency program supervision would be beneficial. C1 ALFRED I DUPONT INST,DEPT PEDIAT,WILMINGTON,DE 19899. WALTER REED ARMY MED CTR,DEPT PEDIAT,WASHINGTON,DC. RP WEISS, JC (reprint author), THOMAS JEFFERSON UNIV,JEFFERSON MED COLL,DEPT PEDIAT,1025 WALNUT ST,PHILADELPHIA,PA 19107, USA. NR 8 TC 6 Z9 6 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0002-922X J9 AM J DIS CHILD JI Am. J. Dis. Child. PD APR PY 1991 VL 145 IS 4 BP 449 EP 452 PG 4 WC Pediatrics SC Pediatrics GA FE884 UT WOS:A1991FE88400014 PM 2012030 ER PT J AU SARNO, AP AF SARNO, AP TI THE SIGNIFICANCE OF AMNIOTIC-FLUID VOLUME DURING INTRAPARTUM FETAL ACOUSTIC STIMULATION SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY LA English DT Article DE AMNIOTIC FLUID VOLUME; FETAL HEART RATE; FETAL ACOUSTIC STIMULATION AB The relationship of intrapartum fluid volume to the fetal response to acoustic stimulation was investigated in 112 patients who were in the latent phase of labor. Amniotic fluid volume appears to play an insignificant role in the genesis of fetal heart rate decelerations that occur after fetal acoustic stimulation, regardless of the amount of amniotic fluid present. C1 UNIV SO CALIF,LOS ANGELES CTY MED CTR,WOMENS HOSP,DEPT OBSTET & GYNECOL,DIV MATERNAL FETAL MED,LOS ANGELES,CA 90033. RP SARNO, AP (reprint author), TRIPLER ARMY MED CTR,DEPT OBSTET & GYNECOL,HONOLULU,HI 96859, USA. NR 3 TC 3 Z9 3 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0002-9378 J9 AM J OBSTET GYNECOL JI Am. J. Obstet. Gynecol. PD APR PY 1991 VL 164 IS 4 BP 1100 EP 1101 PG 2 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA FG945 UT WOS:A1991FG94500024 PM 2014832 ER PT J AU HINKES, MJ AF HINKES, MJ TI REGIONAL ATLAS OF BONE-DISEASE - MANN,RW, MURPHY,SP SO AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY LA English DT Book Review RP HINKES, MJ (reprint author), USA,CENT IDENTIFICAT LAB,FT SHAFTER,HI, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0002-9483 J9 AM J PHYS ANTHROPOL JI Am. J. Phys. Anthropol. PD APR PY 1991 VL 84 IS 4 BP 497 EP 498 DI 10.1002/ajpa.1330840416 PG 2 WC Anthropology; Evolutionary Biology SC Anthropology; Evolutionary Biology GA FD934 UT WOS:A1991FD93400015 ER PT J AU SAENZ, RE DERODRIGUEZ, CG JOHNSON, CM BERMAN, JD AF SAENZ, RE DERODRIGUEZ, CG JOHNSON, CM BERMAN, JD TI EFFICACY AND TOXICITY OF PENTOSTAM AGAINST PANAMANIAN MUCOSAL LEISHMANIASIS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID SODIUM STIBOGLUCONATE AB We tested the World Health Organization (WHO) recommended treatment for mucosal leishmaniasis in 16 Panamanians with disease due to Leishmania braziliensis panamensis. Disease was mild in this population because it was limited to the nasal mucosa and only one patient had septal perforation. The patients were administered 20 mg antimony (in the form of Pentostam) per kg intravenously each day for 28 days. Ten patients completed therapy and were cured at 12 month follow-up. Three patients completed therapy, healed their lesions, but relapsed at the six or 12 month follow-up. Three patients terminated therapy prematurely because of liver enzyme elevations in conjunction with either EKG abnormalities or musculoskeletal complaints; none of these patients were healed. This study indicates that in patients with mild mucosal leishmaniasis, the WHO regimen is curative in 77% patients who complete treatment and in 63% of all patients. C1 SANTO TOMAS HOSP,PANAMA CITY,PANAMA. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. RP SAENZ, RE (reprint author), GORGAS MEM LAB,PANAMA CITY,PANAMA. NR 9 TC 22 Z9 23 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD APR PY 1991 VL 44 IS 4 BP 394 EP 398 PG 5 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA FQ879 UT WOS:A1991FQ87900006 PM 1645930 ER PT J AU UDOMSANGPETCH, R BROWN, AE SMITH, CD WEBSTER, HK AF UDOMSANGPETCH, R BROWN, AE SMITH, CD WEBSTER, HK TI ROSETTE FORMATION BY PLASMODIUM-COATNEYI-INFECTED RED-BLOOD-CELLS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID ERYTHROCYTES; MALARIA; CYTOADHERENCE AB Animal models are needed for the study of cytoadherence in falciparum malaria. Red blood cell (RBC) rosette formation is one type of cytoadherence and appears to be associated with knob formation, endothelial cell adhesion and sequestration of Plasmodium-infected RBCs. Since Plasmodium coatneyi-infected RBCs develop knobs and sequester, we hypothesized that they also form rosettes. RBCs from P. coatneyi-infected rhesus monkeys (Macaca-mulatta) were collected, allowed to mature overnight in vitro and found to form rosettes as hypothesized. This observation adds to the known falciparum-like characteristics of P. coatneyi, and suggests that the Macaca mulatta-P. coatneyi model may be appropriate for pathophysiologic studies of cytoadherence. C1 USA,MED COMPONENT,ARMED FORCES RES INST MED SCI,BANGKOK,THAILAND. RP UDOMSANGPETCH, R (reprint author), MAHIDOL UNIV,FAC SCI,DEPT PATHOBIOL,BANGKOK 10700,THAILAND. NR 11 TC 32 Z9 33 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD APR PY 1991 VL 44 IS 4 BP 399 EP 401 PG 3 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA FQ879 UT WOS:A1991FQ87900007 PM 1904195 ER PT J AU PARRISH, JD HEINS, DC BAKER, JA AF PARRISH, JD HEINS, DC BAKER, JA TI REPRODUCTIVE SEASON, CLUTCH PARAMETERS AND OOCYTE SIZE OF THE JOHNNY DARTER ETHEOSTOMA-NIGRUM FROM SOUTHWESTERN MISSISSIPPI SO AMERICAN MIDLAND NATURALIST LA English DT Article ID MULTIPLE CLUTCHES; PERCIDAE; GROWTH AB Reproductive period, clutch size, clutch mass and oocyte size of the johnny darter Etheostoma nigrum were studied in Mississippi near the southern extreme of its range. Spawning occurred during mid-March to mid-May. Clutch size varied from 54-192 ova in females 34-52 mm standard length. The mean diameter of mature oocytes adjusted for female size was 0.99 mm, and ripening oocytes averaged 1.19 mm in diam. Etheostoma nigrum spawns about 1 mo earlier in Mississippi than in most of its range which extends N into Canada. Clutch sizes vary among populations of the johnny darter; however, insufficient data exist to establish a geographical pattern of variation. Comparisons of clutch sizes must be made with caution and propagule sizes cannot be compared due to lack of standardization in methodology. C1 US ARMY ENGINEER WATERWAYS EXPTL STN,ENVIRONM LAB,VICKSBURG,MS 39180. RP PARRISH, JD (reprint author), TULANE UNIV,DEPT ECOL EVOLUT & ORGANISMAL BIOL,NEW ORLEANS,LA 70118, USA. NR 21 TC 10 Z9 10 U1 0 U2 4 PU AMER MIDLAND NATURALIST PI NOTRE DAME PA UNIV NOTRE DAME, NOTRE DAME, IN 46556 SN 0003-0031 J9 AM MIDL NAT JI Am. Midl. Nat. PD APR PY 1991 VL 125 IS 2 BP 180 EP 186 DI 10.2307/2426221 PG 7 WC Biodiversity Conservation; Ecology SC Biodiversity & Conservation; Environmental Sciences & Ecology GA FP088 UT WOS:A1991FP08800002 ER PT J AU LEE, MS WAKEFIELD, PE KONZELMAN, JL JAMES, WD AF LEE, MS WAKEFIELD, PE KONZELMAN, JL JAMES, WD TI ORAL INSERTABLE PROSTHETIC DEVICE AS AN AID IN TREATING ORAL ULCERS SO ARCHIVES OF DERMATOLOGY LA English DT Article ID LUPUS-ERYTHEMATOSUS RP LEE, MS (reprint author), WALTER REED ARMY MED CTR,WASHINGTON,DC 20307, USA. NR 8 TC 13 Z9 13 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0003-987X J9 ARCH DERMATOL JI Arch. Dermatol. PD APR PY 1991 VL 127 IS 4 BP 479 EP 480 DI 10.1001/archderm.127.4.479 PG 2 WC Dermatology SC Dermatology GA FF033 UT WOS:A1991FF03300003 PM 2006873 ER PT J AU SCHEROKMAN, B VUKELJA, SJ MAY, E AF SCHEROKMAN, B VUKELJA, SJ MAY, E TI ANGIOFOLLICULAR LYMPH-NODE HYPERPLASIA AND PERIPHERAL NEUROPATHY - CASE-REPORT AND LITERATURE-REVIEW SO ARCHIVES OF INTERNAL MEDICINE LA English DT Review ID CASTLEMANS DISEASE; MONOCLONAL GAMMOPATHY; MEDIASTINUM AB A man with multicentric angiofollicular lymph node hyperplasia and a polyclonal gammopathy developed a debilitating sensory-motor peripheral neuropathy that resolved with plasmapheresis and immunosuppressive therapy. Fourteen similar cases have been reported in the literature; however, to our knowledge, this is the first report of successful treatment with plasmapheresis. Severe peripheral neuropathy usually occurs in the setting of multicentric, plasma cell-type disease with hypergammaglobulinemia and is often responsive to immunosuppressive therapy. C1 WALTER REED ARMY MED CTR,HEMATOL SERV,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,NEUROL SERV,WASHINGTON,DC 20307. RP SCHEROKMAN, B (reprint author), UNIFORMED SERV UNIV HLTH SCI,DEPT NEUROL,4301 JONES BRIDGE RD,BETHESDA,MD 20889, USA. NR 18 TC 9 Z9 9 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0003-9926 J9 ARCH INTERN MED JI Arch. Intern. Med. PD APR PY 1991 VL 151 IS 4 BP 789 EP 790 DI 10.1001/archinte.151.4.789 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA FF779 UT WOS:A1991FF77900029 PM 1849398 ER PT J AU BACH, DE BURGESS, LPA ZISLIS, T QUIGLEY, N HOLLINGER, JO AF BACH, DE BURGESS, LPA ZISLIS, T QUIGLEY, N HOLLINGER, JO TI CRANIAL, ILIAC, AND DEMINERALIZED FREEZE-DRIED BONE-GRAFTS OF THE MANDIBLE IN DOGS SO ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY LA English DT Article ID INDUCED OSTEOGENESIS; ENDOCHONDRAL BONE; FACIAL DEFECTS; AUTOGRAFTS; REPAIR; TRANSPLANTATION; RECONSTRUCTION; ALLOGRAFTS; SURGERY; MATRIX AB Both autogenous bone grafts and demineralized freeze-dried allogeneic bone implants were evaluated for mandibular reconstruction. Four-centimeter segmental defects of the midbody of the edentulous mandible were reconstructed in 36 dogs, with specimens recovered at 3 and 6 months and quantitatively compared for total and new bone by histomorphometric analysis. Autogenous grafts consisted of corticocancellous cranial block (CB), corticocancellous iliac block (IB), and particulate cancellous iliac marrow (PM). The allogeneic bone was demineralized and freeze-dried, and consisted of particulate cortical endochondral bone (FP), cranial cortical block (FCB), and iliac cortical block (FIB). Clinically and histomorphometrically, results appeared to indicate that (1) CB compared favorably with IB at 3 and 6 months for total bone, but IB showed a trend for more new bone formation at 6 months, a trend that may be due to the thicker cortical component of CB, which requires longer time periods to remodel than the cancellous rich IB; (2) FP failed to achieve bony union at 3 months, with inadequate rates of new bone formation; and (3) FCB and FIB compared favorably for total bone with CB and IB at 6 months, although new bone for autogenous CB and IB was 26.9% and 45.4%, while new bone for allogeneic FCB and FIB represented only 7.9% and 17.4%. C1 USA,WALTER REED ARMY INST RES,INST DENT RES,WASHINGTON,DC 20310. WALTER REED ARMY MED CTR,OTOLARYNGOL HEAD & NECK SURG SERV,WASHINGTON,DC 20307. NR 49 TC 5 Z9 6 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0886-4470 J9 ARCH OTOLARYNGOL JI Arch. Otolaryngol. Head Neck Surg. PD APR PY 1991 VL 117 IS 4 BP 390 EP 395 PG 6 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA FF344 UT WOS:A1991FF34400006 PM 2007007 ER PT J AU HEMLER, DE WARD, WK KARSTETTER, KW BRYANT, PM AF HEMLER, DE WARD, WK KARSTETTER, KW BRYANT, PM TI SAPHENOUS NERVE ENTRAPMENT CAUSED BY PES ANSERINE BURSITIS MIMICKING STRESS-FRACTURE OF THE TIBIA SO ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION LA English DT Note DE BURSITIS; INJURIES; SAPHENOUS AB Numerous studies have addressed saphenous nerve entrapment at the level of the adductor canal. In this case, we report an entrapment syndrome located further distally occurring as part of an athletic overuse injury. Distal tibial pain, initially managed as a stress fracture, resolved when a pes anserine bursitis was treated. This was associated with return of saphenous nerve potentials along the tibia. C1 FITZSIMONS ARMY MED CTR,PHYS THERAPY SERV,AURORA,CO 80045. WALTER REED ARMY MED CTR,PHYS MED & REHABIL SERV,WASHINGTON,DC 20307. FITZSIMONS ARMY MED CTR,PODIATRY SERV,AURORA,CO 80045. RP HEMLER, DE (reprint author), FITZSIMONS ARMY MED CTR,PHYS MED & REHABIL SERV,AURORA,CO 80045, USA. NR 10 TC 15 Z9 16 U1 0 U2 1 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0003-9993 J9 ARCH PHYS MED REHAB JI Arch. Phys. Med. Rehabil. PD APR PY 1991 VL 72 IS 5 BP 336 EP 337 PG 2 WC Rehabilitation; Sport Sciences SC Rehabilitation; Sport Sciences GA FF342 UT WOS:A1991FF34200015 PM 2009053 ER PT J AU FLETCHER, JE JIANG, MS GONG, QH SMITH, LA AF FLETCHER, JE JIANG, MS GONG, QH SMITH, LA TI SNAKE-VENOM CARDIOTOXINS AND BEE VENOM MELITTIN ACTIVATE PHOSPHOLIPASE-C ACTIVITY IN PRIMARY CULTURES OF SKELETAL-MUSCLE SO BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE LA English DT Article DE FATTY ACIDS; DIACYLGLYCEROL; CYTOTOXINS; PHOSPHOLIPASE-A2; PHOSPHOLIPASE-C ID MALIGNANT HYPERTHERMIA; COBRA VENOMS; HEMOLYSIS; MEMBRANE; CELLS; ERYTHROCYTES AB The effects of cardiotoxin fractions from Naja naja kaouthia and Naja naja atra snake venoms and synthetic melittin peptide were examined on lipolytic activity in red blood cells and primary skeletal muscle cultures. Both native cardiotoxin fractions caused considerable production of free fatty acids in red blood cells. This production was abolished when the fractions were first treated with p-bromophenacyl bromide to reduce the venom phospholipase A2 activity contamination. In equine and human primary cultures of skeletal muscle, the N. n. kaouthia cardiotoxin (10-mu-M) and melittin (2-mu-M) caused a breakdown of phospholipids and production of free fatty acids and diacylglycerol in the absence of lysophospholipid formation. Additionally, melittin at higher concentrations (10-mu-M) caused triglyceride breakdown. These studies do not support the suggestion that snake venom cardiotoxins and melittin selectively activate endogenous phospholipase A2 activity. Instead, the toxins primarily activate endogenous phospholipase C activity and, in the case of melittin at high concentrations, triglyceride lipase activity. C1 USA,MED RES INST INFECT DIS,DEPT TOXINOL,DIV PATHOL,FREDERICK,MD 21701. RP FLETCHER, JE (reprint author), HAHNEMANN UNIV,DEPT ANESTHESIOL,PHILADELPHIA,PA 19102, USA. NR 27 TC 35 Z9 35 U1 0 U2 0 PU NATL RESEARCH COUNCIL CANADA PI OTTAWA PA RESEARCH JOURNALS, MONTREAL RD, OTTAWA ON K1A 0R6, CANADA SN 0829-8211 J9 BIOCHEM CELL BIOL JI Biochem. Cell Biol. PD APR PY 1991 VL 69 IS 4 BP 274 EP 281 PG 8 WC Biochemistry & Molecular Biology; Cell Biology SC Biochemistry & Molecular Biology; Cell Biology GA FJ185 UT WOS:A1991FJ18500011 PM 2054159 ER PT J AU MOORE, DH HAYWARD, IJ TUCKER, FS LUKEY, B AF MOORE, DH HAYWARD, IJ TUCKER, FS LUKEY, B TI HI-6 AND 2-PAM IN SHEEP - PHARMACOKINETICS AND EFFECTS ON MUSCLE-TISSUE FOLLOWING INTRAMUSCULAR INJECTION SO BIOPHARMACEUTICS & DRUG DISPOSITION LA English DT Article DE HI-6; 2-PAM; PHARMACOKINETICS; SHEEP; INTRAMUSCULAR; IRRITANCY ID RABBITS; PIGS AB The pharmacokinetics of 2-PAM, a component of the current nerve agent antidote therapy for U.S. military forces was compared to the pharmacokinetics of another acetylcholinesterase reactivator HI-6. Additionally, the effects of these compounds on muscle tissue following intramuscular injection was examined. Plasma concentrations of the oximes were determined by HPLC. Plasma concentration-time profiles for both oximes fit a one-compartment open model with first-order absorption and elimination. The results demonstrate that the half-time of absorption of the two oximes are nearly the same while the maximum plasma concentration of HI-6 was significantly higher than that for 2-PAM. Musculoirritancy was assessed on the basis of quantitative histological examinations of the injection sites and by the measurement of serum creatinine phosphokinase. Comparison of the scores from the histological sections demonstrate no difference between the two oximes. Serum creatinine phosphokinase values were elevated following injections of HI-6, but were not consistently elevated following the 2-PAM injections. RP MOORE, DH (reprint author), USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010, USA. NR 18 TC 13 Z9 13 U1 1 U2 1 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0142-2782 J9 BIOPHARM DRUG DISPOS JI Biopharm. Drug Dispos. PD APR PY 1991 VL 12 IS 3 BP 223 EP 232 DI 10.1002/bdd.2510120307 PG 10 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA FG451 UT WOS:A1991FG45100006 PM 2059672 ER PT J AU SHIH, TM AF SHIH, TM TI CHOLINERGIC ACTIONS OF DIAZEPAM AND ATROPINE SULFATE IN SOMAN POISONING SO BRAIN RESEARCH BULLETIN LA English DT Article DE SOMAN; DIAZEPAM; ATROPINE SULFATE; CHOLINESTERASE ACTIVITY; ACETYLCHOLINE; CHOLINE; CONVULSIONS; ANTICONVULSANT; DRUG INTERACTION; CHOLINERGIC EFFECTS ID GAMMA-AMINOBUTYRIC ACID; CEREBRAL CORTICAL SLICES; RAT-BRAIN; INDUCED CONVULSIONS; CHOLINESTERASE INHIBITION; ACETYLCHOLINE-RELEASE; NERVE AGENTS; TOXICITY; AREAS; PRETREATMENT AB The effectiveness of diazepam alone or in the presence of atropine sulfate in reversing soman-induced convulsions, inhibition of blood and brain cholinesterase (ChE) activity, and elevation of brain acetylcholine (ACh) and choline (Ch) concentrations in rats was studied. Diazepam (5 mg/kg, IM) blocked the convulsive activity of soman (100-mu-g/kg, SC) whereas atropine sulfate (12 mg/kg, IM) did not. Inclusion of atropine sulfate enhanced the anticonvulsant effects of diazepam. Neither diazepam nor atropine sulfate alone affected ChE activity in the blood and brain of rats, nor did they alone, or in combination, reverse the ChE inhibition induced by soman. Diazepam by itself caused an increase in ACh concentrations in the striatum and a decrease in Ch concentrations in the cortex and striatum. On the other hand, atropine sulfate produced a decrease in ACh and an increase in Ch concentrations in these two brain regions. With combined treatment, diazepam reversed the effect of atropine sulfate on brain ACh and Ch concentrations. Diazepam attenuated the soman-induced elevation of ACh and Ch concentrations in most of the brain regions studied, while atropine sulfate did not. Only when diazepam was given concurrently with atropine sulfate did the elevated brain ACh or Ch concentrations induced by soman return to normal. These results suggest that the anticonvulsant activity of diazepam in soman poisoning may be partially related to its action on presynaptic cholinergic mechanism. RP SHIH, TM (reprint author), USA,MED RES INST CHEM DEF,BIOCHEM PHARMACOL BRANCH,ABERDEEN PROVING GROUND,MD 21010, USA. NR 75 TC 27 Z9 27 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0361-9230 J9 BRAIN RES BULL JI Brain Res. Bull. PD APR PY 1991 VL 26 IS 4 BP 565 EP 573 PG 9 WC Neurosciences SC Neurosciences & Neurology GA FL893 UT WOS:A1991FL89300012 PM 1868356 ER PT J AU DALY, SF AF DALY, SF TI FRACTURE AND BREAKUP OF RIVER ICE COVER - DISCUSSION SO CANADIAN JOURNAL OF CIVIL ENGINEERING LA English DT Discussion RP DALY, SF (reprint author), USA,COLD REG RES & ENGN LAB,HANOVER,NH 03755, USA. NR 4 TC 0 Z9 0 U1 0 U2 0 PU NATL RESEARCH COUNCIL CANADA PI OTTAWA PA RESEARCH JOURNALS, MONTREAL RD, OTTAWA ON K1A 0R6, CANADA SN 0315-1468 J9 CAN J CIVIL ENG JI Can. J. Civ. Eng. PD APR PY 1991 VL 18 IS 2 BP 337 EP 338 PG 2 WC Engineering, Civil SC Engineering GA FK698 UT WOS:A1991FK69800022 ER PT J AU WARD, FT KELLEY, JA ROTH, JS LOMBARDO, FA WEISS, RB LEYLANDJONES, B CHUN, HG AF WARD, FT KELLEY, JA ROTH, JS LOMBARDO, FA WEISS, RB LEYLANDJONES, B CHUN, HG TI A PHASE-I BIOAVAILABILITY AND PHARMACOKINETIC STUDY OF HEXAMETHYLENE BISACETAMIDE (NSC-95580) ADMINISTERED VIA NASOGASTRIC TUBE SO CANCER RESEARCH LA English DT Article ID DIFFERENTIATING AGENT; LEUKEMIA-CELLS; METABOLITES; INDUCTION; INFUSION; INDUCERS; PLASMA; TRIAL; LINE AB A Phase I clinical trial and pharmacological study of nasogastrically administered hexamethylene bisacetamide, a polar-planar compound with in vitro differentiating activity, was conducted in 14 adult patients with refractory cancer. Hexamethylene bisacetamide was administered as a 5% (w/v) solution via a nasogastric or gastrostomy tube every 4 h for 5 days, followed in 21 days by a 5-day continuous i.v. infusion at the same daily dose. Parenteral drug administration was then continued at the same interval in the absence of disease progression or unacceptable toxicity. Three patients each were treated at doses of 12 and 24 g/m2/day, while eight patients received a dose of 30 g/m2/day. Toxicity was comparable for both routes of drug administration at the above doses. Nasogastrically administered hexamethylene bisacetamide was well tolerated at the lower doses, whereas neurotoxicity and nausea and vomiting were the major, but manageable, toxicities at 30 g/m2/day. Metabolic acidosis, renal dysfunction, mucositis, and thrombocytopenia were the other commonly observed drug toxicities at this dose. No objective tumor responses were observed. Hexamethylene bisacetamide was rapidly absorbed from the gastrointestinal tract with a mean measured bioavailability of 99 +/- 15%. Pharmacokinetic parameters for hexamethylene bisacetamide and plasma concentrations of the two major metabolites, N-acetyl-1,6-diaminohexane and 6-acetamidohexanoic acid, were similar for either route of administration in individual patients. Hexamethylene bisacetamide exhibited apparent monoexponential plasma elimination after either nasogastric or parenteral administration with 27 to 60% of the administered dose being excreted in the urine as parent compound. Based on its demonstrated complete bioavailability and tolerability, nasogastric administration of hexamethylene bisacetamide can be directly and safely substituted for the comparable i.v. dose. C1 WALTER REED ARMY MED CTR,DEPT MED,HEMATOL ONCOL SERV,WASHINGTON,DC 20307. NCI,DIV CANC TREATMENT,CANC THERAPY EVALUAT PROGRAM,INVEST DRUG BRANCH,BETHESDA,MD 20892. NCI,DIV CANC TREATMENT,DEV THERAPEUT PROGRAM,MED CHEM LAB,BETHESDA,MD 20892. NR 24 TC 13 Z9 13 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA PUBLIC LEDGER BLDG, SUITE 816, 150 S. INDEPENDENCE MALL W., PHILADELPHIA, PA 19106 SN 0008-5472 J9 CANCER RES JI Cancer Res. PD APR 1 PY 1991 VL 51 IS 7 BP 1803 EP 1810 PG 8 WC Oncology SC Oncology GA FE041 UT WOS:A1991FE04100009 PM 2004365 ER PT J AU JAROS, DL AF JAROS, DL TI CLOSING HAZARDOUS LANDFILLS SO CIVIL ENGINEERING LA English DT Article RP JAROS, DL (reprint author), USA,CORP ENGINEERS,MISSOURI RIVER DIV,OMAHA,NE 68102, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASCE-AMER SOC CIVIL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0885-7024 J9 CIVIL ENG JI Civil Eng. PD APR PY 1991 VL 61 IS 4 BP 65 EP 67 PG 3 WC Engineering, Civil SC Engineering GA FD403 UT WOS:A1991FD40300019 ER PT J AU SHANLEY, DJ BUCKNER, AB ALEXANDER, HG AF SHANLEY, DJ BUCKNER, AB ALEXANDER, HG TI THE SCINTIGRAPHIC DUODENAL CUT-OFF SIGN IN ACUTE-PANCREATITIS SO CLINICAL NUCLEAR MEDICINE LA English DT Article ID CT; SONOGRAPHY AB Acute pancreatitis is a dreaded complication of biliary calculus disease, and several radiographic signs have been reported in association with this condition. We report a new sign demonstrated on hepatobiliary scintigraphy, the duodenal cut off sign, seen in a patient being evaluated for stone disease and later found to have acute pancreatitis. Hepatobiliary scans are commonly performed during the initial evaluation of patients with suspected calculus disease, and visualization of this sign may indicate to the clinician that he is dealing with a more serious condition. RP SHANLEY, DJ (reprint author), TRIPLER ARMY MED CTR,DEPT RADIOL & NUCL MED,HONOLULU,HI 96859, USA. NR 7 TC 1 Z9 1 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0363-9762 J9 CLIN NUCL MED JI Clin. Nucl. Med. PD APR PY 1991 VL 16 IS 4 BP 223 EP 225 DI 10.1097/00003072-199104000-00001 PG 3 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA FF513 UT WOS:A1991FF51300001 PM 2044313 ER PT J AU CROSS, AS OPAL, SM PALARDY, JE BODMER, MW SADOFF, JC AF CROSS, AS OPAL, SM PALARDY, JE BODMER, MW SADOFF, JC TI THE EFFICACY OF COMBINATION IMMUNOTHERAPY IN EXPERIMENTAL PSEUDOMONAS SEPSIS SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 BROWN UNIV,PROVIDENCE,RI 02912. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. CELLTECH LTD,SLOUGH,ENGLAND. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0009-9279 J9 CLIN RES JI Clin. Res. PD APR PY 1991 VL 39 IS 2 BP A214 EP A214 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA FH323 UT WOS:A1991FH32300421 ER PT J AU DIEMER, MM COOPER, GS HARVEY, J JEFFERS, DJ NOEL, GL AF DIEMER, MM COOPER, GS HARVEY, J JEFFERS, DJ NOEL, GL TI TAKING A SEXUAL HISTORY - EVALUATION OF RESIDENTS SKILLS SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,DEPT MED,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0009-9279 J9 CLIN RES JI Clin. Res. PD APR PY 1991 VL 39 IS 2 BP A616 EP A616 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA FH323 UT WOS:A1991FH32302734 ER PT J AU DOMLOGEHULTSCH, N BENSON, P GAMMON, WR YANCEY, KB AF DOMLOGEHULTSCH, N BENSON, P GAMMON, WR YANCEY, KB TI AN ATYPICAL BULLOUS SKIN-DISEASE (BSD) PATIENT WITH ANTIBASEMENT MEMBRANE ZONE (BMZ) ANTIBODIES RECOGNIZING SEPARATE EPITOPES IN 1M NACL SPLIT SKIN (SSS) SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. UNIV N CAROLINA,CHAPEL HILL,NC 27514. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0009-9279 J9 CLIN RES JI Clin. Res. PD APR PY 1991 VL 39 IS 2 BP A477 EP A477 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA FH323 UT WOS:A1991FH32301907 ER PT J AU DRABICK, J BHATTACHARJEE, A ALVING, C SCHWARTZ, G SADOFF, J CROSS, A AF DRABICK, J BHATTACHARJEE, A ALVING, C SCHWARTZ, G SADOFF, J CROSS, A TI REACTOGENICITY OF A PANEL OF ANTI-LIPID-A REAGENTS WITH LIPID-A AND ITS COMPONENTS SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,DEPT BACTERIAL DIS,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT BIOCHEM,WASHINGTON,DC 20307. NR 0 TC 1 Z9 1 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0009-9279 J9 CLIN RES JI Clin. Res. PD APR PY 1991 VL 39 IS 2 BP A175 EP A175 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA FH323 UT WOS:A1991FH32300202 ER PT J AU GONG, R ABRAMS, JR WADE, CE GOUGE, SF SOLIMANDO, DA LOOMIS, R GILDENGORIN, V WHITAKER, WR LINDBERG, JS AF GONG, R ABRAMS, JR WADE, CE GOUGE, SF SOLIMANDO, DA LOOMIS, R GILDENGORIN, V WHITAKER, WR LINDBERG, JS TI COMPARISON OF HYPERTONIC SALINE SOLUTIONS WITH AND WITHOUT DEXTRAN IN THE TREATMENT OF DIALYSIS-INDUCED HYPOTENSION (DIH) SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 LETTERMAN ARMY MED CTR,SAN FRANCISCO,CA 94129. INST RES,SAN FRANCISCO,CA. BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0009-9279 J9 CLIN RES JI Clin. Res. PD APR PY 1991 VL 39 IS 2 BP A456 EP A456 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA FH323 UT WOS:A1991FH32301797 ER PT J AU HENNESSEY, PTG AF HENNESSEY, PTG TI COMMON SYMPTOMS AS MARKERS FOR ALCOHOLISM SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,GEN MED SVC,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0009-9279 J9 CLIN RES JI Clin. Res. PD APR PY 1991 VL 39 IS 2 BP A576 EP A576 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA FH323 UT WOS:A1991FH32302497 ER PT J AU JACKSON, S TSENG, YL LAHIRI, S DAVIS, JC BURMAN, KD WARTOFSKY, L AF JACKSON, S TSENG, YL LAHIRI, S DAVIS, JC BURMAN, KD WARTOFSKY, L TI ENDOTHELIN AND THE THYROID - TISSUE RECEPTORS AND CLINICAL CORRELATES SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0009-9279 J9 CLIN RES JI Clin. Res. PD APR PY 1991 VL 39 IS 2 BP A207 EP A207 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA FH323 UT WOS:A1991FH32300380 ER PT J AU KARK, JA KARK, RAP ANDERSON, L SALAZAR, AM ESTELLA, E AF KARK, JA KARK, RAP ANDERSON, L SALAZAR, AM ESTELLA, E TI NEUROLOGIC DIAGNOSIS IN EXERTIONAL HEAT ILLNESS SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. USN,MED CLIN BRANCH,MARINE CORP RECRUIT DEPOT,PARRIS ISL,SC. UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0009-9279 J9 CLIN RES JI Clin. Res. PD APR PY 1991 VL 39 IS 2 BP A412 EP A412 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA FH323 UT WOS:A1991FH32301536 ER PT J AU KARK, JA GARDNER, JW HETZEL, DP JARMULOWICZ, MA LARKIN, TJ FRANCIS, LFD ANDERSON, L ESTELLA, E AF KARK, JA GARDNER, JW HETZEL, DP JARMULOWICZ, MA LARKIN, TJ FRANCIS, LFD ANDERSON, L ESTELLA, E TI FEVER IN CLASSIFICATION OF EXERTIONAL HEAT INJURY SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,DIV MED,WASHINGTON,DC 20307. BRANCH CLIN,DEPT NURSING,PARRIS ISL,SC. USN HOSP,DEPT INTERNAL MED,BEAUFORT,SC. UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0009-9279 J9 CLIN RES JI Clin. Res. PD APR PY 1991 VL 39 IS 2 BP A143 EP A143 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA FH323 UT WOS:A1991FH32300011 ER PT J AU KROENKE, K LUCAS, CA BOGGI, JO ROSENBERG, M HERBERS, JE WEHRLE, PA SCHEROKMAN, BJ AF KROENKE, K LUCAS, CA BOGGI, JO ROSENBERG, M HERBERS, JE WEHRLE, PA SCHEROKMAN, BJ TI THE DIZZY PATIENT - WHO GETS BETTER SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 UNIFORMED SERV UNIV HLTH SCI,DEPT MED,BETHESDA,MD 20814. UNIFORMED SERV UNIV HLTH SCI,DEPT NEUROL,BETHESDA,MD 20814. UNIFORMED SERV UNIV HLTH SCI,DEPT OPHTHALMOL,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 2 Z9 2 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0009-9279 J9 CLIN RES JI Clin. Res. PD APR PY 1991 VL 39 IS 2 BP A579 EP A579 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA FH323 UT WOS:A1991FH32302515 ER PT J AU LANDRY, FJ PHILLIPS, YY PARKER, JM AF LANDRY, FJ PHILLIPS, YY PARKER, JM TI OUTCOME OF CARDIOPULMONARY-RESUSCITATION IN THE INTENSIVE-CARE SETTING SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,DEPT MED,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0009-9279 J9 CLIN RES JI Clin. Res. PD APR PY 1991 VL 39 IS 2 BP A580 EP A580 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA FH323 UT WOS:A1991FH32302518 ER PT J AU LEYDEN, JJ MCGINLEY, KJ SMITH, KJ JAMES, WD AF LEYDEN, JJ MCGINLEY, KJ SMITH, KJ JAMES, WD TI STAPHYLOCOCCUS-AUREUS COLONIZATION OF MULTIPLE SITES IN HIV POSITIVE PATIENTS SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 UNIV PENN,SCH MED,DEPT DERMATOL,PHILADELPHIA,PA 19104. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0009-9279 J9 CLIN RES JI Clin. Res. PD APR PY 1991 VL 39 IS 2 BP A565 EP A565 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA FH323 UT WOS:A1991FH32302433 ER PT J AU MALIK, A EGAN, JE SEDEGAH, M MASON, C HOFFMAN, SL AF MALIK, A EGAN, JE SEDEGAH, M MASON, C HOFFMAN, SL TI IMMUNIZATION OF HUMANS WITH RADIATION ATTENUATED SPOROZOITES INDUCES CYTOTOXIC-T LYMPHOCYTES (CTL) AGAINST THE PLASMODIUM-FALCIPARUM CIRCUMSPOROZOITE PROTEIN SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 USN,BETHESDA,MD. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0009-9279 J9 CLIN RES JI Clin. Res. PD APR PY 1991 VL 39 IS 2 BP A328 EP A328 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA FH323 UT WOS:A1991FH32301059 ER PT J AU MCQUEEN, C BOEDEKER, E GOMEZ, J FLEMING, E WOLF, M LE, M BROWN, W AF MCQUEEN, C BOEDEKER, E GOMEZ, J FLEMING, E WOLF, M LE, M BROWN, W TI PRIMARY INFECTION WITH ENTEROADHERENT ESCHERICHIA-COLI (RDEC-1) RESULTS IN AN ENHANCED IMMUNOLOGICAL RESPONSE AND PROTECTION AGAINST CHALLENGE SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. VET ADM MED CTR,DENVER,CO 80220. UNIV COLORADO,MED CTR,DENVER,CO 80202. NR 0 TC 1 Z9 1 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0009-9279 J9 CLIN RES JI Clin. Res. PD APR PY 1991 VL 39 IS 2 BP A442 EP A442 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA FH323 UT WOS:A1991FH32301714 ER PT J AU OMORI, DM SIMMONS, JO MEIER, NJ AF OMORI, DM SIMMONS, JO MEIER, NJ TI PENDING LABS FOLLOWING HOSPITAL DISCHARGE SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,DEPT MED,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. BROOKE ARMY MED CTR,SAN ANTONIO,TX. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0009-9279 J9 CLIN RES JI Clin. Res. PD APR PY 1991 VL 39 IS 2 BP A606 EP A606 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA FH323 UT WOS:A1991FH32302675 ER PT J AU WESTERVELT, P TROWBRIDGE, DB GENDELMAN, HE RATNER, L AF WESTERVELT, P TROWBRIDGE, DB GENDELMAN, HE RATNER, L TI REGULATION OF SILENT AND PRODUCTIVE HIV-1 INFECTION IN PRIMARY MONOCYTES BY 2 DISTINCT GENETIC-DETERMINANTS SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 WASHINGTON UNIV,SCH MED,DEPT MED,ST LOUIS,MO 63110. WASHINGTON UNIV,SCH MED,DEPT MOLEC MICROBIOL,ST LOUIS,MO 63110. WALTER REED ARMY RES INST,ROCKVILLE,MD. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0009-9279 J9 CLIN RES JI Clin. Res. PD APR PY 1991 VL 39 IS 2 BP A283 EP A283 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA FH323 UT WOS:A1991FH32300827 ER PT J AU YUAN, CM NGUYEN, J SPANDE, H PAMNANI, MB AF YUAN, CM NGUYEN, J SPANDE, H PAMNANI, MB TI EFFECTS OF ORAL ARGININE ON BLOOD-PRESSURE IN RENIN DEPENDENT HYPERTENSION IN RATS SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,NEPHROL SERV,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. NR 0 TC 1 Z9 1 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 USA SN 0009-9279 J9 CLIN RES JI Clin. Res. PD APR PY 1991 VL 39 IS 2 BP A379 EP A379 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA FH323 UT WOS:A1991FH32301345 ER PT J AU MOLLOY, M PEURA, DA AF MOLLOY, M PEURA, DA TI STRESS RELATED MUCOSAL DAMAGE - INCIDENCE, PATHOGENESIS, AND STRATEGIES FOR MANAGEMENT - REPLY SO COMPLICATIONS IN SURGERY LA English DT Letter RP MOLLOY, M (reprint author), USA,IRELAND HOSP,DEPT SURG,FT KNOX,KY 40121, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SCP COMMUNICATIONS INC PI NEW YORK PA 134 W 29TH ST, NEW YORK, NY 10001-5304 SN 1053-749X J9 COMPLICATION SURG JI Complicat. Surg. PD APR PY 1991 VL 10 IS 4 BP 6 EP 6 PG 1 WC Surgery SC Surgery GA FG085 UT WOS:A1991FG08500003 ER PT J AU CARR, LW CHANDRASEKHARA, MS AF CARR, LW CHANDRASEKHARA, MS TI A STUDY OF COMPRESSIBILITY EFFECTS ON DYNAMIC STALL OF RAPIDLY PITCHING AIRFOILS SO COMPUTER PHYSICS COMMUNICATIONS LA English DT Article AB Results of recent experimental studies into the effect of compressibility on dynamic stall of oscillating airfoils are reviewed. Stroboscopic schlieren images of the strongly unsteady flow field are presented, showing the development of the dynamic stall vortex, and its progression down the airfoil. The effect of varying free-stream Mach number, and frequency of oscillation of the airfoil are demonstrated, and examples of local supersonic flow are presented, including the presence of a shock near the leading edge of the airfoil. C1 USA,AEROFLIGHTDYNAM DIRECTORATE,AVSCOM,MOFFETT FIELD,CA 94035. NASA,NAVAL POSTGRAD SCH,JOINT INST AERONAUT,DEPT AERONAUT & ASTRONAUT,MONTEREY,CA 94943. RP CARR, LW (reprint author), NASA,AMES RES CTR,FLUID MECH LAB,MOFFETT FIELD,CA 94035, USA. NR 9 TC 1 Z9 1 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0010-4655 J9 COMPUT PHYS COMMUN JI Comput. Phys. Commun. PD APR PY 1991 VL 65 IS 1-3 BP 62 EP 68 DI 10.1016/0010-4655(91)90155-E PG 7 WC Computer Science, Interdisciplinary Applications; Physics, Mathematical SC Computer Science; Physics GA FM805 UT WOS:A1991FM80500009 ER PT J AU BJORNSON, DC OSTER, CN HINER, WO TRAMONT, EC AF BJORNSON, DC OSTER, CN HINER, WO TRAMONT, EC TI THE RELATIONSHIP BETWEEN OUTPATIENT DRUG COSTS AND DISEASE PROGRESSION IN THE HUMAN IMMUNODEFICIENCY VIRUS-INFECTED POPULATION SO DICP-THE ANNALS OF PHARMACOTHERAPY LA English DT Article ID MEDICAL-CARE COSTS; UNITED-STATES; HIV INFECTION; AIDS; CLASSIFICATION; IMPACT AB As the foucs of the management of human immunodeficiency virus (HIV) infection turns from the treatment of AIDS to the entire continuum of the disease, projection of long-term healthcare costs becomes increasingly important. Rather than a fulminant disease treated primarily inside the hospital, HIV infection will become a chronic condition requiring years of outpatient monitoring and pharmacologic intervention with attending increases in pharmacy costs. The objective of this study was to characterize outpatient drug costs by Walter Reed (WR) disease stage in order to estimate the association of disease progression and outpatient prescription drug costs. We hypothesized that there was an association between HIV disease progression, measured by the WR Staging Classification System, and outpatient prescription drug costs. Outpatient drug costs were summarized for 190 HIV-positive patients during a three-month period who presented at Walter Reed Army Medical Center for staging and follow-up. The overall median cost per day per patient for all stages was $3.21 (range $0.01-53.45) with wide variation between patients. Daily costs for patients in WR stage V were the greatest (median $9.26). There was a significant association between WR stage of disease and outpatient drug costs (Spearman rho = 0.51, t = 6.9, df = 188, p < 0.001). The association was not completely linear because costs in WR stage VI were less than WR stages IV or V. Annual extrapolated outpatient drug costs for these 190 patients would be nearly $0.5 million. C1 WALTER REED ARMY MED CTR,INFECT DIS SERV,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,PHARM SERV,WASHINGTON,DC 20307. RP BJORNSON, DC (reprint author), WALTER REED ARMY MED CTR,HIV RES PROGRAM,WASHINGTON,DC 20307, USA. NR 12 TC 3 Z9 3 U1 1 U2 1 PU HARVEY WHITNEY BOOKS CO PI CINCINNATI PA PO BOX 42696, CINCINNATI, OH 45242 SN 0012-6578 J9 DICP ANN PHARMAC PD APR PY 1991 VL 25 IS 4 BP 414 EP 417 PG 4 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA FH024 UT WOS:A1991FH02400017 PM 1926913 ER PT J AU HAN, SY KIM, TJ ADIGUZEL, I AF HAN, SY KIM, TJ ADIGUZEL, I TI XPLANNER - A KNOWLEDGE-BASED DECISION SUPPORT SYSTEM FOR FACILITY MANAGEMENT AND PLANNING SO ENVIRONMENT AND PLANNING B-PLANNING & DESIGN LA English DT Article AB A case study is reported of the design, implementation, and evaluation of a knowledge-based decision support system, XPLanner. XPLanner integrates an expert system with optimization modeling technique, database management system, and interactive user interface to create a comprehensive decision aid for facility management and planning by the US Army. It is believed that integrating the expert system with the modeling and data management capabilities of decision support systems can create a computer system which effectively supports the combination of rational and heuristic paradigms which characterize the problem-solving approach to planning. C1 UNIV ILLINOIS,DEPT URBAN & REG PLANNING,CHAMPAIGN,IL 61820. USA,CORPS ENGINEERS,CONSTRUCT ENGN RES LAB,CHAMPAIGN,IL 61821. RP HAN, SY (reprint author), KYUNG HEE UNIV,DEPT PUBL ADM,SUWON 449701,SOUTH KOREA. NR 19 TC 5 Z9 5 U1 0 U2 3 PU PION LTD PI LONDON PA 207 BRONDESBURY PARK, LONDON, ENGLAND NW2 5JN SN 0265-8135 J9 ENVIRON PLANN B JI Environ. Plan. B-Plan. Des. PD APR PY 1991 VL 18 IS 2 BP 205 EP 224 DI 10.1068/b180205 PG 20 WC Environmental Studies SC Environmental Sciences & Ecology GA FR560 UT WOS:A1991FR56000009 ER PT J AU GRODOWITZ, MJ STEWART, RM COFRANCESCO, AF AF GRODOWITZ, MJ STEWART, RM COFRANCESCO, AF TI POPULATION-DYNAMICS OF WATER-HYACINTH AND THE BIOLOGICAL-CONTROL AGENT NEOCHETINA-EICHHORNIAE (COLEOPTERA, CURCULIONIDAE) AT A SOUTHEAST TEXAS LOCATION SO ENVIRONMENTAL ENTOMOLOGY LA English DT Article DE INSECTA; CURCULIONIDAE; BIOLOGICAL CONTROL; WATER-HYACINTH AB Population dynamics of waterhyacinth, Eichhornia crassipes ((Martinus) Solms-Laubach), and a biological control agent, the weevil Neochetina eichhorniae (Warner), were quantified at a site in Wallisville, Tex., during 1987 and 1988. A decline of waterhyacinth occurred that was most pronounced during the 1988 growing season. Changes included decreases in (1) living above water biomass/m2 (almost-equal-to -57%), (2) living below water biomass/m2 (almost-equal-to -39%), (3) number of living leaves/plant (almost-equal-to -50%), and (4) weight/plant (-40%). Associated with these decreases was a 1.5-fold increase in plant density. The waterhyacinth was severely damaged by N. eichhorniae. Highest numbers of N. eichhorniae adults (> 55 weevils/m2) occurred in samples collected 15 September 1987. Decreases in the number of weevils for both sexes followed. Declines approached 8 weevils/m2 per month for the following 5 mo. Numbers of pupae per square meter decreased during 1987 by 7.3 pupae/m2 per month. Larval density increased during the winter months with highest larval density noted during December and January. This peak was followed by decreases in third instars of almost-equal-to 80%. Increases in the number of adults and third instars occurred during the 1988 growing season, however, pupal density remained low (near 0) thereafter. Environmental factors that contributed to the waterhyacinth declines included a drought, nutrient conditions, intermittent freezing temperatures, as well as sustained N. eichhorniae herbivory. RP GRODOWITZ, MJ (reprint author), USA,CORPS ENGINEERS,USDA ARS,AQUAT PLANT MANAGEMENT LAB,WATERWAYS EXPT,VICKSBURG,MS 39180, USA. NR 19 TC 9 Z9 9 U1 1 U2 4 PU ENTOMOL SOC AMER PI LANHAM PA 9301 ANNAPOLIS RD, LANHAM, MD 20706 SN 0046-225X J9 ENVIRON ENTOMOL JI Environ. Entomol. PD APR PY 1991 VL 20 IS 2 BP 652 EP 660 PG 9 WC Entomology SC Entomology GA FH315 UT WOS:A1991FH31500038 ER PT J AU QIGUI, L MINGDA, Z HUMPEL, M AF QIGUI, L MINGDA, Z HUMPEL, M TI INVESTIGATIONS ON THE INVITRO METABOLISM OF 5 SYNTHETIC 19-NORPROGESTINS USING HEPATOCYTE SUSPENSIONS ISOLATED FROM 5 LABORATORY-ANIMAL SPECIES SO EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS LA English DT Article DE 19-NORPROGESTINS (NORETHISTERONE, NET; LEVONORGESTREL, LN; GESTODENE, GEST; NET-3-OXIME, NETO; NORGESTIMATE, NGM); HEPATOCYTES; INVITRO METABOLISM; RAT; GUINEA PIG; RABBIT; DOG (BEAGLE); CYNOMOLGUS MONKEY ID RAT AB Five synthetic progestins of the 19-nortestosterone type (norethisterone, NET; levonorgestrel, LN; gestodene, GEST; NET-3-oxime, NETO; norgestimate, NGM) were investigated in the in vitro hepatocyte model. Radiolabelled progestins were added to hepatocyte suspensions (3 x 10(6) cells/ml) freshly prepared from female rat, guinea pig, rabbit, dog (beagle) and cynomolgus monkey. Drug level decreases (NET, LN, GEST) and prodrug conversions (NETO, NGM) were followed by radiochromatography (HPLC) for 60 min. In the case of NET and NETO the conversion into ethinyl estradiol (EE2) was quantified by RIA after HPLC separation. Half-lives of drug level decreases (t1/2), areas under the curves (AUC) and metabolic clearance rates (MCR) were estimated for all progestins. For NETO and NGM the percentages of conversion into NET and LN were calculated, respectively, and levels of EE2 determined in the case of NET and NETO. Rat hepatocytes showed an extremely high metabolic activity towards NET, LN and GEST resulting in t1/2 values of below 2 min. Respective values for rabbit hepatocytes ranged from 5-8 min, whereas half-lives calculated for liver cells from guinea pig, dog and monkey were generally above 30 min. A drastic increase in t1/2 was found for NETO (as compared to NET) in hepatocytes from rat, rabbit and monkey but not from guinea pig. Dog hepatocytes degraded NETO about 3 times more rapidly than NET. NGM was degraded much faster than LN in hepatocytes from all species except the rat. Liver cells from guinea pig and dog seem to be able to metabolize the 3-oxime group much more rapidly than hepatocytes from the other animal species. The lowest degree of prodrug conversion of 4% was observed for NGM and dog hepatocytes. Elevated EE2 levels were found in all experiments with NET and NETO. Results of NET, LN and GEST were compared with published in vivo experiments. No correlations were found for t1/2, MCR, and AUC. C1 SCHERING AG,MUELLERSTR 170-178,W-1000 BERLIN 65,GERMANY. TONJI MED UNIV,FAMILY PLANNING RES INST,WUHAN,PEOPLES R CHINA. WALTER REED ARMY MED CTR,DEPT PHARMACOL,WASHINGTON,DC 20307. NR 23 TC 2 Z9 2 U1 0 U2 4 PU MEDECINE ET HYGIENE PI CHENE BOURG PA 46, CHEMIN DE LA MOUSSE, CHENE BOURG, SWITZERLAND SN 0378-7966 J9 EUR J DRUG METAB PH JI Eur. J. Drug Metabol. Pharmacokinet. PD APR-JUN PY 1991 VL 16 IS 2 BP 93 EP 102 PG 10 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA GH488 UT WOS:A1991GH48800002 PM 1936077 ER PT J AU FUGATE, DS THOMSON, JD CHRISTENSEN, KP AF FUGATE, DS THOMSON, JD CHRISTENSEN, KP TI AN IRREDUCIBLE FRACTURE-DISLOCATION OF A LESSER TOE - A CASE-REPORT SO FOOT & ANKLE LA English DT Article AB Lesser toe dislocations are unusual injuries that are amenable to closed reduction in most cases. We present a case of an isolated lesser toe fracture-dislocation that required an open reduction due to soft tissue interposition. RP FUGATE, DS (reprint author), TRIPLER ARMY MED CTR,ORTHOPED SERV,HONOLULU,HI 96859, USA. NR 0 TC 8 Z9 8 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0198-0211 J9 FOOT ANKLE PD APR PY 1991 VL 11 IS 5 BP 317 EP 318 PG 2 WC Orthopedics SC Orthopedics GA FJ703 UT WOS:A1991FJ70300009 PM 2037272 ER PT J AU STEMLER, FW TEZAKREID, TM MCCLUSKEY, MP KAMINSKIS, A CORCORAN, KD SHIH, ML STEWART, JR WADE, JV HAYWARD, IJ AF STEMLER, FW TEZAKREID, TM MCCLUSKEY, MP KAMINSKIS, A CORCORAN, KD SHIH, ML STEWART, JR WADE, JV HAYWARD, IJ TI PHARMACOKINETICS AND PHARMACODYNAMICS OF OXIMES IN UNANESTHETIZED PIGS SO FUNDAMENTAL AND APPLIED TOXICOLOGY LA English DT Article ID CHOLINESTERASE; PRALIDOXIME RP STEMLER, FW (reprint author), USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010, USA. NR 25 TC 10 Z9 10 U1 0 U2 3 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0272-0590 J9 FUND APPL TOXICOL JI Fundam. Appl. Toxicol. PD APR PY 1991 VL 16 IS 3 BP 548 EP 558 DI 10.1016/0272-0590(91)90094-K PG 11 WC Toxicology SC Toxicology GA FE983 UT WOS:A1991FE98300015 PM 1855625 ER PT J AU SAUCIER, RT AF SAUCIER, RT TI GEOARCHAEOLOGICAL EVIDENCE OF STRONG PREHISTORIC EARTHQUAKES IN THE NEW MADRID (MISSOURI) SEISMIC ZONE SO GEOLOGY LA English DT Article AB Sand blows and fissures that cover > 10500 km2 in northeastern Arkansas and southeastern Missouri attest to the severity of the 1811-1812 earthquake series in the New Madrid seismic zone. However, except for one occurrence near New Madrid, Mossouri, the region has been devoid of any evidence of other major shocks for at least 1.3 ka prior to 1811 and possibly for > 9 ka. Stratigraphic relations and radiocarbon dating at a recently excavated archaeological site near East Prairie, Missouri, have revealed liquefaction phenomena attributable to a shock dated to within about 100 yr prior to A.D. 539 and a probable second one dated between about A.D. 539 and 991. RP SAUCIER, RT (reprint author), USA,ENGN WATERWAYS EXPT STN,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 12 TC 39 Z9 40 U1 1 U2 3 PU GEOLOGICAL SOC AMERICA PI BOULDER PA PO BOX 9140 3300 PENROSE PLACE, BOULDER, CO 80301 SN 0091-7613 J9 GEOLOGY JI Geology PD APR PY 1991 VL 19 IS 4 BP 296 EP 298 DI 10.1130/0091-7613(1991)019<0296:GEOSPE>2.3.CO;2 PG 3 WC Geology SC Geology GA FE841 UT WOS:A1991FE84100002 ER PT J AU CHAPMAN, C BOSSCHER, J REMMENGA, S PARK, R BARNHILL, D AF CHAPMAN, C BOSSCHER, J REMMENGA, S PARK, R BARNHILL, D TI A TECHNIQUE FOR MANAGING TERMINALLY ILL OVARIAN-CARCINOMA PATIENTS SO GYNECOLOGIC ONCOLOGY LA English DT Article ID PERCUTANEOUS ENDOSCOPIC GASTROSTOMY; TOTAL PARENTERAL-NUTRITION; SMALL BOWEL OBSTRUCTION; CANCER-PATIENTS; PAIN; MANAGEMENT; ANALGESIA C1 WALTER REED ARMY MED CTR,DEPT OBSTET & GYNECOL,GYNECOL ONCOL SERV,WASHINGTON,DC 20307. RP CHAPMAN, C (reprint author), WALTER REED ARMY MED CTR,DEPT OBSTET & GYNECOL,WASHINGTON,DC 20307, USA. NR 12 TC 14 Z9 14 U1 0 U2 0 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0090-8258 J9 GYNECOL ONCOL JI Gynecol. Oncol. PD APR PY 1991 VL 41 IS 1 BP 88 EP 91 DI 10.1016/0090-8258(91)90262-4 PG 4 WC Oncology; Obstetrics & Gynecology SC Oncology; Obstetrics & Gynecology GA FN284 UT WOS:A1991FN28400017 PM 1902811 ER PT J AU COZZA, KL HALES, RE AF COZZA, KL HALES, RE TI PSYCHIATRY IN THE ARMY - A BRIEF HISTORICAL-PERSPECTIVE AND CURRENT DEVELOPMENTS SO HOSPITAL AND COMMUNITY PSYCHIATRY LA English DT Article ID STATES MILITARY PERSONNEL; TOBACCO USE; PREVALENCE; FAMILY; COMMUNITY; ALCOHOL; HEALTH AB A brief historical review of military psychiatry in the United States Army is presented, focusing on the development of psychiatric treatment of soldiers with acute stress reactions. The authors outline the current roles of the military psychiatrist during peace-time and war, including direct care provider, consultant, and administrator, and discuss the contributions of military psychiatry to the civilian sector in the areas of crisis intervention, community psychiatry, family psychiatry, and substance abuse prevention and treatment. C1 PACIFIC PRESBYTERIAN MED CTR,SAN FRANCISCO,CA 94115. LETTERMAN ARMY MED CTR,DEPT CLIN INVEST,SAN FRANCISCO,CA 94129. RP COZZA, KL (reprint author), WALTER REED ARMY MED CTR,DEPT PSYCHIAT,WASHINGTON,DC 20307, USA. NR 36 TC 5 Z9 5 U1 0 U2 0 PU AMER PSYCHIATRIC ASSOCIATION PI WASHINGTON PA 1400 K ST NW, WASHINGTON, DC 20005 SN 0022-1597 J9 HOSP COMMUNITY PSYCH PD APR PY 1991 VL 42 IS 4 BP 413 EP 418 PG 6 WC Public, Environmental & Occupational Health; Psychiatry SC Public, Environmental & Occupational Health; Psychiatry GA FD969 UT WOS:A1991FD96900015 PM 2050356 ER PT J AU PODLESAK, TF CARTER, JL MCMURRAY, JA AF PODLESAK, TF CARTER, JL MCMURRAY, JA TI DEMONSTRATION OF COMPACT SOLID-STATE OPENING AND CLOSING SWITCH UTILIZING GTOS IN SERIES SO IEEE TRANSACTIONS ON ELECTRON DEVICES LA English DT Article AB A compact opening and closing solid-state switch has been designed, constructed, and demonstrated. The switch has successfully repetitively switched over 4 MW of peak power and yet measures only 0.45 m by 0.12 m by 0.32 m and has a mass of 13 kg. The switch uses commercially available gate turn-off thyristors (GTO's), arranged in series to enable the collected devices to switch a voltage five times the rating of an individual device. This differs from previous arrangements of GTO's in series, where the applied voltage did not exceed the rated voltage of one device. The former arrangement was only one device working with one or more backups. The system uses exclusively commercially available components, yet takes advantage of state-of-the-art components. These include multilayer ceramic capacitors, which are arrayed to produce a snubber capacitor, and small high-voltage isolated power transformers that protect each of the seven GTO stages from breakdown damage via their power supplies. Each stage was controlled via a fiber-optic link, and turn-on and turn-off times were adjustable for each of the seven stages. System dV/dt (exceeded 1 kV/mu-s and system di/dt exceed 200 A/mu-s, for both turn-on and turn-off. The system was only limited, in the amount of power it could switch, by thermal considerations. A much higher power could be switched if there had been advanced cooling. The cooling devices were quite modest, in that this was only a demonstration of the principle. More sophisticated cooling could produce a much more powerful system. Although the GTO's used are small, and the same results could be obtained with one single large device, it is the researcher's intent to array these same large devices in a similar manner, in order to produce an opening and closing switch capable of repetitively switching tens of kilovolts and tens of megawatts peak power. C1 VITRON,EATONTOWN,NJ. RP PODLESAK, TF (reprint author), USA,ELECTR TECHNOL & DEVICES LAB,FT MONMOUTH,NJ 07703, USA. NR 1 TC 2 Z9 2 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9383 J9 IEEE T ELECTRON DEV JI IEEE Trans. Electron Devices PD APR PY 1991 VL 38 IS 4 BP 706 EP 711 DI 10.1109/16.75193 PG 6 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA FC049 UT WOS:A1991FC04900006 ER PT J AU SERCARZ, E KRZYCH, U AF SERCARZ, E KRZYCH, U TI THE DISTINCTIVE SPECIFICITY OF ANTIGEN-SPECIFIC SUPPRESSOR T-CELLS SO IMMUNOLOGY TODAY LA English DT Review ID EGG-WHITE LYSOZYME; EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; MYELIN BASIC-PROTEIN; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; LACTATE-DEHYDROGENASE-B; BOVINE SERUM-ALBUMIN; BETA-GALACTOSIDASE; IMMUNE-RESPONSES; INVITRO INDUCTION; FINE SPECIFICITY AB Although suppressor T cells have been cloned in only a few instances, the existence of a functional cadre of T cells that acts to downregulate the immune response is well documented. In this review Eli Sercarz and Urszula Krzych describe studies on suppressor T-cell (T(S)-cell) specificity that provide some support for the conclusion that the T(S) cell is a distinctive cell type with an expressed repertoire that is different from that expressed by helper T (T(H)) cells. They go on to explore the interaction between cells recognizing T(S)-cell-inducing determinants (SDs) and T(H)-cell-inducing determinants (HDs), and their relationship to immunogenicity and Ir gene effects. C1 WALTER REED ARMY MED CTR,DEPT IMMUNOL,WASHINGTON,DC 20307. RP SERCARZ, E (reprint author), UNIV CALIF LOS ANGELES,DEPT MICROBIOL & MOLEC GENET,LOS ANGELES,CA 90024, USA. FU NCI NIH HHS [CA-24442]; NIAID NIH HHS [AI-11183] NR 72 TC 94 Z9 95 U1 0 U2 2 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB SN 0167-5699 J9 IMMUNOL TODAY JI Immunol. Today PD APR PY 1991 VL 12 IS 4 BP 111 EP 118 DI 10.1016/0167-5699(91)90094-A PG 8 WC Immunology SC Immunology GA FH078 UT WOS:A1991FH07800005 PM 1711854 ER PT J AU BERZINS, K PERLMANN, H WAHLIN, B EKRE, HP HOGH, B PETERSEN, E WELLDE, B SCHOENBECHLER, M WILLIAMS, J CHULAY, J PERLMANN, P AF BERZINS, K PERLMANN, H WAHLIN, B EKRE, HP HOGH, B PETERSEN, E WELLDE, B SCHOENBECHLER, M WILLIAMS, J CHULAY, J PERLMANN, P TI PASSIVE-IMMUNIZATION OF AOTUS MONKEYS WITH HUMAN-ANTIBODIES TO THE PLASMODIUM-FALCIPARUM ANTIGEN PF155 RESA SO INFECTION AND IMMUNITY LA English DT Article ID INHIBIT MEROZOITE INVASION; MALARIA VACCINES; ERYTHROCYTES; SEQUENCES; INVITRO; SERA AB In order to assess the protective effects of anti-Pf155/RESA antibodies of different specificities in vivo, passive immunizations of Aotus monkeys were performed. Antibodies reactive with the Pf155/RESA repeat sequences (EENV) 2 and EENVEHDA were isolated from the immunoglobulin G (IgG) fraction of a pool of plasmas from Liberia by affinity chromatography on synthetic peptides. The two fractions of antibodies differed in specificity but displayed similar capacities to inhibit merozoite invasion in Plasmodium falciparum in vitro cultures. Four groups of monkeys (named groups I to IV) were injected with (i) 160 mg of total control IgG, (ii) 2 mg of IgG affinity purified on (EENV) 2, (iii) 2 mg of IgG affinity purified on EENVEHDA, and (iv) 160 mg of total immune IgG, respectively. The monkeys were then challenged with P. falciparum-infected erythrocytes, and the levels of parasitemia and hematocrits as well as other serological parameters were determined daily. Although all groups developed parasitemia, groups II and IV tended to show lower mean daily levels. Three monkeys of group II and two monkeys (each) of groups III and IV self cured the infections, but so did one monkey from the group treated with control IgG (group I). The serum levels of transfused antibodies were low at the peak of parasitemia, suggesting that clearance of parasites was mediated by immune responses mounted by the monkeys. The results indicate that antibodies to epitopes formed by repeats of Pf155/RESA may depress P. falciparum parasitemias and thus that immunogens based on such repeats should be suitable components in a subunit vaccine against asexual stages of P. falciparum. C1 KABIBIOPHARM,RES & DEV IMMUNOBIOL,S-11287 STOCKHOLM,SWEDEN. KAROLINSKA INST,DEPT INFECT DIS,S-11489 STOCKHOLM,SWEDEN. LIBERIAN INST BIOMED RES,MALARIA RES UNIT,CHARLESVILLE,LIBERIA. WALTER REED ARMY MED CTR,DEPT IMMUNOL,WASHINGTON,DC 20307. RP BERZINS, K (reprint author), UNIV STOCKHOLM,DEPT IMMUNOL,S-10691 STOCKHOLM,SWEDEN. NR 30 TC 40 Z9 40 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0019-9567 J9 INFECT IMMUN JI Infect. Immun. PD APR PY 1991 VL 59 IS 4 BP 1500 EP 1506 PG 7 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA FD915 UT WOS:A1991FD91500039 PM 2004828 ER PT J AU KRAEMER, WJ GORDON, SE FLECK, SJ MARCHITELLI, LJ MELLO, R DZIADOS, JE FRIEDL, K HARMAN, E MARESH, C FRY, AC AF KRAEMER, WJ GORDON, SE FLECK, SJ MARCHITELLI, LJ MELLO, R DZIADOS, JE FRIEDL, K HARMAN, E MARESH, C FRY, AC TI ENDOGENOUS ANABOLIC HORMONAL AND GROWTH-FACTOR RESPONSES TO HEAVY RESISTANCE EXERCISE IN MALES AND FEMALES SO INTERNATIONAL JOURNAL OF SPORTS MEDICINE LA English DT Article DE GROWTH HORMONE; INSULIN-LIKE GROWTH FACTOR-I; TESTOSTERONE; ANAEROBIC EXERCISE; SOMATOMEDINS; RESISTANCE EXERCISE; BLOOD LACTATE ID HUMAN SKELETAL-MUSCLE; SERUM TESTOSTERONE; MEN; WOMEN; YOUNG; STRENGTH; PLASMA AB To examine endogenous anabolic hormonal responses to two different types of heavy resistance exercise protocols (HREPs), eight male and eight female subjects performed two randomly assigned protocols (i. e. P-1 and P-2) on separate days. Each protocol consisted of eight identically ordered exercises carefully designed to control for load, rest period length, and total work (J) effects. P-1 utilized a 5 RM load, 3-min rest periods and had lower total work than P-2. P-2 utilized a 10 RM load, 1-min rest periods and had a higher total work than P-1. Whole blood lactate and serum glucose, human growth hormone (hGH), testosterone (T), and somatomedin-C [SM-C] (i. e. insulin-like growth factor 1, IGF-1) were determined pre-exercise, mid-exercise (i. e. after 4 of the 8 exercises), and at 0, 5, 15, 30, and 60 min post-exercise. Males demonstrated significant (p < 0.05) increases above rest in serum T values, and all serum concentrations were greater than corresponding female values. Growth hormone increases in both males and females following the P-2 HREP were significantly greater at all timepoints than corresponding P-1 values. Females exhibited significantly higher pre-exercise hGH levels compared to males. The P-1 exercise protocol did not result in any hGH increases in females. SM-C demonstrated random significant increases above rest in both males and females in response to both HREPs. These data suggest that the hormonal response patterns to HREPs are variable and in females differ from those in males due to significantly higher pre-exercise and exercise-induced serum T levels in males and higher pre-exercise serum hGH concentrations in females. C1 UNIV CONNECTICUT,DEPT PHYSIOL & NEUROBIOL,STORRS,CT 06259. US OLYMP COMM,SPORT SCI PROGRAM,COLORADO SPRINGS,CO 80909. USA,ENVIRONM MED RES INST,DIV EXERCISE PHYSIOL,NATICK,MA 01760. UNIV CONNECTICUT,EXERCISE SCI PROGRAM,STORRS,CT 06259. RP KRAEMER, WJ (reprint author), PENN STATE UNIV,CTR SPORTS MED,GREENBERG SPORTS COMPLEX,UNIVERSITY PK,PA 16802, USA. OI Friedl, Karl/0000-0002-3134-8427 NR 34 TC 292 Z9 295 U1 3 U2 23 PU GEORG THIEME VERLAG PI STUTTGART PA P O BOX 30 11 20, D-70451 STUTTGART, GERMANY SN 0172-4622 J9 INT J SPORTS MED JI Int. J. Sports Med. PD APR PY 1991 VL 12 IS 2 BP 228 EP 235 DI 10.1055/s-2007-1024673 PG 8 WC Sport Sciences SC Sport Sciences GA FM573 UT WOS:A1991FM57300012 PM 1860749 ER PT J AU NEUFER, PD SAWKA, MN YOUNG, AJ QUIGLEY, MD LATZKA, WA LEVINE, L AF NEUFER, PD SAWKA, MN YOUNG, AJ QUIGLEY, MD LATZKA, WA LEVINE, L TI HYPOHYDRATION DOES NOT IMPAIR SKELETAL-MUSCLE GLYCOGEN RESYNTHESIS AFTER EXERCISE SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE CARBOHYDRATE METABOLISM; DEHYDRATION; MUSCLE WATER; RECOVERY FROM EXERCISE ID CARBOHYDRATE INGESTION; PROLONGED EXERCISE; HEAT ACCLIMATION; DYNAMIC EXERCISE; WATER; REPLETION; TISSUES; REST AB The purpose of this investigation was to examine the effects of moderate hypohydration (HY) on skeletal muscle glycogen resynthesis after exhaustive exercise. On two occasions, eight males completed 2 h of intermittent cycle ergometer exercise (4 bouts of 17 min at 60% and 3 min at 80% of maximal O2 consumption/10 min rest) to reduce muscle glycogen concentrations (control values 711 +/- 41-mu-mol/g dry wt). During one trial, cycle exercise was followed by several hours of light upper body exercise in the heat without fluid replacement to induce HY (-5% body wt); in the second trial, sufficient water was ingested during the upper body exercise and heat exposure to maintain euhydration (EU). In both trials, 400 g of carbohydrate were ingested at the completion of exercise and followed by 15 h of rest while the desired hydration level was maintained. Muscle biopsy samples were obtained from the vastus lateralis immediately after intermittent cycle exercise (T1) and after 15 h or rest (T2). During the HY trial, the muscle water content was lower (P < 0.05) at T1 and T2 (288 +/- 9 and 265 +/- 5 ml/100 g dry wt, respectively; NS) than during EU (313 +/- 8 and 301 +/- 4 ml/100 g dry wt, respectively; NS). Muscle glycogen concentration was not significantly different during EU and HY at T1 (200 +/- 35 vs. 251 +/- 50-mu-mol/g dry wt) or T2 (452 +/- 34 vs. 491 +/- 35-mu-mol/g dry wt). These data indicate that, despite reduced water content during the first 15 h after heavy exercise, skeletal muscle glycogen resynthesis is not impaired. C1 USA,ENVIRONM MED RES INST,DIV THERMAL PHYSIOL & MED,KANSAS ST,NATICK,MA 01760. NR 31 TC 22 Z9 23 U1 1 U2 1 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 8750-7587 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD APR PY 1991 VL 70 IS 4 BP 1490 EP 1494 PG 5 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA FF832 UT WOS:A1991FF83200008 PM 2055825 ER PT J AU HANKE, DW NELSON, ME BASKIN, SI AF HANKE, DW NELSON, ME BASKIN, SI TI CARDIOTONIC DRUGS INHIBIT PURIFIED MAMMALIAN ACETYLCHOLINESTERASE SO JOURNAL OF APPLIED TOXICOLOGY LA English DT Article DE CARDIOTONIC DRUGS; ORGANOPHOSPHONATE; VX; OXIME; PURIFIED MAMMALIAN ACETYLCHOLINESTERASE; REACTIVATION ID FETAL BOVINE SERUM; OUABAIN; DISSOCIATION; PURIFICATION; ENZYME; ATPASE AB Oxime- and non-oxime-related drugs, as well as cardionic drugs (CDs), have been used to treat the effects of organophosphorus (OP) poisoning. We conducted our experiments to determine what effects CDs may have on acetylcholinesterase (AChE), and how CDs interact with other treatment drugs as well as with OP-inhibited AChE. True AChE (EC 3.1.1.7) was purified from fetal bovine serum, and enzyme activity was measured according to Ellman et al. The CDs coumingine, cassaine, proscillaridin and convallatoxin were incubated with AChE at 550-mu-M at pH 7.6 and 25-degrees-C. The CD ouabain was incubated with AChE at 500-mu-M. The CDs inhibited AChE by 97%, 89%, 10%, 7% and 6%, respectively. The mean AChE activities for these experiments, except for ouabian, were significantly different (P = 0.05) from their controls, as determined by the two-tailed Student's t-test. In a separate experiment, the oxime TMB-4.2Br (100-mu-M), which did not inhibit AChE, increased the inhibitory effect of proscillaridin from 4% to 11% (a 3.7-fold increase). When AChE was inhibited 39% with 37 nM VX, the addition of proscillaridin increased the inhibition to 51% (a 1.3-fold increase). When TMB-4 was added to the proscillaridin- and VX-inhibited AChE mixture, the inhibition decreased from 50% to 32% (a 0.37-fold decrease), whereas TMB-4 alone added to VX-inhibited AChE decreased the inhibition from 39% to 24% (a 0.38-fold decrease). The results show that TMB-4 increases the inhibition of AChE by proscillaridin. However, TMB-4 decreases the inhibition of AChE by VX and proscillaridin combined. The inhibition of AChE by the CDs alone may help in part to account for the cardiac parasympathetic response of CDs. C1 USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010. US EPA,OFF PESTICIDES & TOX SUBSTANCES,WASHINGTON,DC 20460. NR 26 TC 4 Z9 4 U1 0 U2 1 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0260-437X J9 J APPL TOXICOL JI J. Appl. Toxicol. PD APR PY 1991 VL 11 IS 2 BP 119 EP 124 DI 10.1002/jat.2550110209 PG 6 WC Toxicology SC Toxicology GA FC706 UT WOS:A1991FC70600008 PM 2061549 ER PT J AU FRICKE, RF JORGE, J AF FRICKE, RF JORGE, J TI METHYLTHIAZOLIDINE-4-CARBOXYLATE FOR TREATMENT OF ACUTE T-2 TOXIN EXPOSURE SO JOURNAL OF APPLIED TOXICOLOGY LA English DT Article DE GLUTATHIONE; L-CYSTEINE PRODRUGS; METHYLTHIAZOLIDINE-4-CARBOXYLATE; T-2 TOXIN; TRICHOTHECENE MYCOTOXINS ID TRICHOTHECENE MYCOTOXINS; GLUTATHIONE DISULFIDE; PROTECTIVE AGENTS; PROTEIN-SYNTHESIS; OXIDATIVE STRESS; GUINEA-PIGS; L-CYSTEINE; RAT; HEPATOCYTES; PRODRUGS AB The effect of T-2 toxin on hepatic glutathione content and the protective effect of 2-methyl-thiazolidine-4-carboxylate (MTCA), an L-cysteine prodrug, were studied in mice. Acute exposure to T-2 toxin (4 mg kg-1, s.c.) resulted in a progressive decrease in glutathione content, reaching a minimum 6-8 h after toxin administration. Because T-2 toxin caused decreased food consumption, a condition known to deplete hepatic glutathione, glutathione was measured in both fed and fasted control and toxin-treated mice. Glutathione content (mu-mol g-1 tissue) was 9.01 +/- 0.66 (control) and 4.26 +/- 0.41 (toxin) for fed mice, 4.45 +/- 0.39 (control) and 2.45 +/- 0.26 (toxin) for 16-h fasted mice, and 7.18 +/- 0.26 (control) and 3.76 +/- 0.65 (toxin) for mice fed before, but fasted after exposure to toxin. In all cases, toxin treatment resulted in significant decreases in glutathione content compared to controls. Treatment of T-2-intoxicated mice with MTCA (750 mg kg-1, i.p.) not only maintained glutathione content at control levels or higher but significantly improved survival as well. Therefore, the toxicity and lethality of T-2 toxin may be associated with decreased hepatic glutathione content, since MTCA maintained glutathione content and improved survival. C1 USA,MED RES INST INFECT DIS,FREDERICK,MD 21701. NR 32 TC 8 Z9 8 U1 1 U2 4 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0260-437X J9 J APPL TOXICOL JI J. Appl. Toxicol. PD APR PY 1991 VL 11 IS 2 BP 135 EP 140 DI 10.1002/jat.2550110212 PG 6 WC Toxicology SC Toxicology GA FC706 UT WOS:A1991FC70600011 PM 2061552 ER PT J AU OHARA, TM SHEPPARD, MA CLARKE, EC BORZELLECA, JF GENNINGS, C CONDIE, LW AF OHARA, TM SHEPPARD, MA CLARKE, EC BORZELLECA, JF GENNINGS, C CONDIE, LW TI A CCL4/CHCL3 INTERACTION STUDY IN ISOLATED HEPATOCYTES - NONINDUCED AND PHENOBARBITAL-PRETREATED CELLS SO JOURNAL OF APPLIED TOXICOLOGY LA English DT Article DE CARBON TETRACHLORIDE; CHLOROFORM; INTERACTION; RESPONSE SURFACE METHODOLOGY ID CARBON-TETRACHLORIDE TOXICITY; ISOLATED RAT HEPATOCYTES; CHLOROFORM; HEPATOTOXICITY; INVIVO; INVITRO; MODEL AB The purpose of this study was to evaluate an isolated hepatocyte model for predicting the in vivo hepatotoxicity of carbon tetrachloride (CCl4) and chloroform (CHCl3), alone and in combination. Response surface methodology (RSM) was used to analyze and describe the data. The interaction was evaluated for % initial K+ (cell injury) and % LDH leakage (cell death) in non-induced (untreated) and phenobarbital-pretreated suspended hepatocytes. CCl4 and CHCl3 were delivered alone and in combination in dimethyl sulfoxide (DMSO) to suspended hepatocytes. The maximum observed no-effect level (MONEL) for CCl4 in non-induced cells was 1.0 mM (LDH and K+). In induced cells, the MONEL was 0.25 mM (K+) and 0.5 mM (LDH). The MONEL for CHCl3 in non-induced cells was 5.0 mM (LDH and K+) and in induced cells was 0.5 mM (K+) and 1.0 mM (LDH). Phenobarbital pretreatment enhanced the toxicity of both CCl4 and CHCl3, alone and in combination. RSM analysis of the % initial K+ and % LDH for CCl4 and CHCl3 in combination in non-induced and induced cells showed a greater than additive interaction. The isolated hepatocyte model appears to be a promising system for evaluating the toxicity of chemical mixtures and predicting their in vivo effects. C1 VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,DEPT PHARMACOL & TOXICOL,BOX 613,RICHMOND,VA 23298. VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,DEPT BIOSTAT,RICHMOND,VA 23298. USA,DUGWAY PROVING GROUND,UT 84022. NR 26 TC 4 Z9 4 U1 0 U2 1 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0260-437X J9 J APPL TOXICOL JI J. Appl. Toxicol. PD APR PY 1991 VL 11 IS 2 BP 147 EP 154 DI 10.1002/jat.2550110214 PG 8 WC Toxicology SC Toxicology GA FC706 UT WOS:A1991FC70600013 PM 2061553 ER PT J AU HABLE, M STERN, C ASOWATA, C WILLIAMS, K AF HABLE, M STERN, C ASOWATA, C WILLIAMS, K TI THE DETERMINATION OF NITROAROMATICS AND NITRAMINES IN GROUND AND DRINKING-WATER BY WIDE-BORE CAPILLARY GAS-CHROMATOGRAPHY SO JOURNAL OF CHROMATOGRAPHIC SCIENCE LA English DT Article AB A method has been developed to determine the concentration of nitroaromatics and nitramines in drinking water at levels below those previously achieved by gas chromatography. The nitroaromatics and nitramines are extracted from water using toluene and isoamyl acetate, respectively. The extracts are analyzed via a gas chromatograph equipped with a DB-1301 widebore fused-silica capillary column and an electron capture detector. Method detection limits of 0.003-mu-g/L for 2,6-dinitrotoluene (2,6-DNT), 0.04-mu-g/L for 2,4-dinitrotoluene (2,4-DNT), 0.06-mu-g/L for 2,4,6-trinitrotoluene (TNT), 0.3-mu-g/L for cyclotrimethylenetrinitramine (RDX), and 6.0-mu-g/L for cyclotetramethylenetetranitramine (HMX) have been obtained using this method. RP HABLE, M (reprint author), USA,ENVIRONM HYG AGCY,DIV ORGAN ENVIRONM CHEM,ABERDEEN PROVING GROUND,MD 21010, USA. NR 11 TC 43 Z9 43 U1 1 U2 1 PU PRESTON PUBLICATIONS INC PI NILES PA 7800 MERRIMAC AVE PO BOX 48312, NILES, IL 60648 SN 0021-9665 J9 J CHROMATOGR SCI JI J. Chromatogr. Sci. PD APR PY 1991 VL 29 IS 4 BP 131 EP 135 PG 5 WC Biochemical Research Methods; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA FF058 UT WOS:A1991FF05800001 PM 1874908 ER PT J AU BAKER, WJ ROYER, GL WEISS, RB AF BAKER, WJ ROYER, GL WEISS, RB TI CYTARABINE AND NEUROLOGIC TOXICITY SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Review ID DOSE CYTOSINE-ARABINOSIDE; ACUTE NONLYMPHOCYTIC LEUKEMIA; CENTRAL NERVOUS-SYSTEM; ACUTE MYELOGENOUS LEUKEMIA; ACUTE LYMPHOBLASTIC-LEUKEMIA; ACUTE MYELOID-LEUKEMIA; NON-HODGKINS LYMPHOMA; REFRACTORY ACUTE-LEUKEMIA; MYELIN BASIC-PROTEIN; POOR-RISK PATIENTS C1 WALTER REED ARMY MED CTR,MED ONCOL SECT,WASHINGTON,DC 20307. UPJOHN CO,KALAMAZOO,MI 49001. UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. FU NCI NIH HHS [CA-26806] NR 124 TC 153 Z9 155 U1 2 U2 5 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0732-183X J9 J CLIN ONCOL JI J. Clin. Oncol. PD APR PY 1991 VL 9 IS 4 BP 679 EP 693 PG 15 WC Oncology SC Oncology GA FD863 UT WOS:A1991FD86300020 PM 1648599 ER PT J AU GAWRYCH, GW AF GAWRYCH, GW TI THE EGYPTIAN MILITARY DEFEAT OF 1967 SO JOURNAL OF CONTEMPORARY HISTORY LA English DT Article RP GAWRYCH, GW (reprint author), US ARMY COMMAND GENERAL STAFF COLL,DEPT MIL HIST,LEVENWORTH,KS, USA. NR 41 TC 0 Z9 0 U1 0 U2 0 PU SAGE PUBLICATIONS LTD PI LONDON PA 6 BONHILL STREET, LONDON, ENGLAND EC2A 4PU SN 0022-0094 J9 J CONTEMP HIST JI J. Contemp. Hist. PD APR PY 1991 VL 26 IS 2 BP 277 EP 305 DI 10.1177/002200949102600205 PG 29 WC History SC History GA FM391 UT WOS:A1991FM39100005 ER PT J AU BAUMGARTNER, JC FALKLER, WA AF BAUMGARTNER, JC FALKLER, WA TI BIOSYNTHESIS OF IGG IN PERIAPICAL LESION EXPLANT CULTURES SO JOURNAL OF ENDODONTICS LA English DT Article ID ADULT PERIODONTITIS; IMMUNOGLOBULINS AB The presence of immunoglobulins has been demonstrated in periapical inflammatory lesions associated with endodontic disease. The purpose of this study was to determine if IgG is synthesized in vitro in explant cultures of untreated periapical inflammatory lesions and to determine the level of IgG in isolated samples. Periapical lesions associated with infected root canals were removed from the roots and cultured in tissue culture medium containing tritiated amino acids. Supernatant fluids from the explant tissue cultures were passed through staphylococcal protein A affinity columns to isolate IgG. When the staphylococcal protein A eluents (24-h samples) from six periapical lesions were used in double diffusion in agarose assays, the presence of IgG was demonstrated in all the samples. Radial immunodiffusion assays to quantitate the IgG in staphylococcal protein A eluents showed that the levels of IgG detected in each successive daily supernatant fluid always decreased or else fell below the lower limits of detection. The in vitro biosynthesis of IgG in explant cultures of periapical lesions was demonstrated by the incorporation of tritiated amino acids into isolated IgG. C1 WALTER REED ARMY MED CTR,INST DENT RES,MICROBIOL BRANCH,WASHINGTON,DC 20307. UNIV MARYLAND,SCH DENT,DEPT MICROBIOL,BALTIMORE,MD 21201. NR 16 TC 2 Z9 2 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0099-2399 J9 J ENDODONT JI J. Endod. PD APR PY 1991 VL 17 IS 4 BP 143 EP 146 PG 4 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA FE561 UT WOS:A1991FE56100001 PM 1940731 ER PT J AU BAUMGARTNER, JC STANLEY, HR SALOMONE, JL AF BAUMGARTNER, JC STANLEY, HR SALOMONE, JL TI ZEBRA-VI .2. SO JOURNAL OF ENDODONTICS LA English DT Article C1 WALTER REED ARMY MED CTR,INST DENT RES,WASHINGTON,DC 20307. UNIV FLORIDA,COLL DENT,GAINESVILLE,FL 32611. RADER DENT CLIN,FT MYERS,VA. NR 10 TC 1 Z9 1 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0099-2399 J9 J ENDODONT JI J. Endod. PD APR PY 1991 VL 17 IS 4 BP 182 EP 185 PG 4 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA FE561 UT WOS:A1991FE56100010 PM 1940738 ER PT J AU TEZDUYAR, TE SHIH, R AF TEZDUYAR, TE SHIH, R TI NUMERICAL EXPERIMENTS ON DOWNSTREAM BOUNDARY OF FLOW PAST CYLINDER SO JOURNAL OF ENGINEERING MECHANICS-ASCE LA English DT Article AB The influence of the location of the downstream boundary on unsteady incompressible flow solutions is investigated in a series of numerical experiments performed for flow past a circular cylinder at Reynolds number 100. The governing equations are the velocity-pressure formulation of the Navier-Stokes equations, and at the downstream boundary the traction-free condition is imposed. Temporally periodic flow fields obtained by using computational domains with various lengths are compared. It is observed that as far as the near-field solution, the Strouhal number, and the lift and drag coefficients are concerned, the downstream boundary can be placed as close as 14.5 diameters from the center of the cylinder with virtually no difference in the solution. Furthermore, only third-digit variations in the Strouhal number and the lift and drag coefficients and very minor changes in the near-field solution are observed when the downstream boundary is brought as close as 6.5 diameters from the center of the cylinder. Bringing the downstream boundary closer than this seems to result in more significant changes in the solution. In particular, if the distance is 2.6 diameters or closer, the solution becomes symmetric and steady. C1 UNIV MINNESOTA,MINNESOTA SUPERCOMP INST,MINNEAPOLIS,MN 55455. UNIV MINNESOTA,ARMY HIGH PERFORMANCE COMP RES CTR,MINNEAPOLIS,MN 55455. RP TEZDUYAR, TE (reprint author), UNIV MINNESOTA,DEPT AEROSP ENGN & MECH,MINNEAPOLIS,MN 55455, USA. RI Tezduyar, Tayfun/F-6134-2012 OI Tezduyar, Tayfun/0000-0001-8707-3162 NR 6 TC 23 Z9 25 U1 0 U2 1 PU ASCE-AMER SOC CIVIL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-9399 J9 J ENG MECH-ASCE JI J. Eng. Mech.-ASCE PD APR PY 1991 VL 117 IS 4 BP 854 EP 871 DI 10.1061/(ASCE)0733-9399(1991)117:4(854) PG 18 WC Engineering, Mechanical SC Engineering GA FD692 UT WOS:A1991FD69200009 ER PT J AU PETERS, JF AF PETERS, JF TI INSTABILITY OF ANTIGRANULOCYTES MATERIALS WITH NONASSOCIATED FLOW - DISCUSSION SO JOURNAL OF ENGINEERING MECHANICS-ASCE LA English DT Discussion RP PETERS, JF (reprint author), USA,ENGN WTRWAYS,EXPT STN,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 0 TC 8 Z9 8 U1 0 U2 0 PU ASCE-AMER SOC CIVIL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-9399 J9 J ENG MECH-ASCE JI J. Eng. Mech.-ASCE PD APR PY 1991 VL 117 IS 4 BP 934 EP 936 DI 10.1061/(ASCE)0733-9399(1991)117:4(934) PG 3 WC Engineering, Mechanical SC Engineering GA FD692 UT WOS:A1991FD69200016 ER PT J AU DIECKMANN, GS SPINDLER, M LANGE, MA ACKLEY, SF EICKEN, H AF DIECKMANN, GS SPINDLER, M LANGE, MA ACKLEY, SF EICKEN, H TI ANTARCTIC SEA ICE - A HABITAT FOR THE FORAMINIFER NEOGLOBOQUADRINA-PACHYDERMA SO JOURNAL OF FORAMINIFERAL RESEARCH LA English DT Article ID WEDDELL SEA; PACK-ICE; ABUNDANCE AB The pelagic foraminifer Neogloboquadrina pachyderma (Ehrenberg, 1861) occurs in new ice, congelation ice, and the underlying water column of the Weddell Sea. Neogloboquadrina pachyderma is incorporated into the ice in large numbers at the time of its formation. The average number of foraminifers per liter of ice was 87 and numbers ranged between 0 and 1,075. Sea ice contained 70 times more foraminifers per unit volume than the underlying water column and on an areal basis the sea ice cover has approximately the same number of specimens as 60 m of underlying water column. The foraminifera are usually incorporated into the ice when it is being formed dynamically and are thus subsequently associated mainly with granular ice. Many foraminifers are able to survive and grow in the ice where algal biomass in winter is high compared to the water column, perhaps indicating an overwintering strategy. Arctic sea ice, on the other hand, is practically devoid of foraminifers. These observations may have implications for paleoceanographers who use N. pachyderma as a tool to reconstruct past surface water conditions. C1 USA,COLD REG RES & ENGN LAB,HANOVER,NH 03755. RP DIECKMANN, GS (reprint author), ALFRED WEGENER INST POLAR & MARINE RES,COLUMBUSSTR,W-2850 BREMERHAVEN,GERMANY. RI Dieckmann, Gerhard/B-4307-2010; Eicken, Hajo/M-6901-2016 NR 35 TC 38 Z9 40 U1 0 U2 14 PU CUSHMAN FOUNDATION FORAMINIFERAL RES PI CAMBRIDGE PA MUSEUM COMPARATIVE ZOOLOGY, DEPT INVERTEBRATE PALEONTOLOGY 26 OXFORD ST, HARVARD UNIV, CAMBRIDGE, MA 02138 SN 0096-1191 J9 J FORAMIN RES JI J. Foraminifer. Res. PD APR PY 1991 VL 21 IS 2 BP 182 EP 189 PG 8 WC Paleontology SC Paleontology GA FM987 UT WOS:A1991FM98700006 ER PT J AU MYLER, CA BRADSHAW, WM COSMOS, MG AF MYLER, CA BRADSHAW, WM COSMOS, MG TI USE OF WASTE ENERGETIC MATERIALS AS A FUEL SUPPLEMENT IN UTILITY BOILERS SO JOURNAL OF HAZARDOUS MATERIALS LA English DT Article AB Waste energetic material produced during the manufacture of explosives has been considered a by-product waste which must be disposed of. Methods such as open burning or open detonation pose potential environmental risks while disposal in specially designed hazardous waste incinerators is costly. No current method capitalizes on these materials' inherent energy capacity. Efforts to utilize these wastes as supplements to fuel oil are under way. Laboratory and bench scale operations verify the principle while economic analysis shows a positive advantage using this approach. Pilot scale testing is in progress to develop fuel mixing/feeding procedures and to determine fuel mixture energy parameters. RP MYLER, CA (reprint author), USA,TOXIC & HAZARDOUS MAT AGCY,ABERDEEN PROVING GROUND,MD 21010, USA. NR 0 TC 4 Z9 4 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0304-3894 J9 J HAZARD MATER JI J. Hazard. Mater. PD APR PY 1991 VL 26 IS 3 BP 333 EP 342 DI 10.1016/0304-3894(91)85028-L PG 10 WC Engineering, Environmental; Engineering, Civil; Environmental Sciences SC Engineering; Environmental Sciences & Ecology GA FN021 UT WOS:A1991FN02100005 ER PT J AU MAYNORD, ST RUFF, JF ABT, SR AF MAYNORD, ST RUFF, JF ABT, SR TI RIPRAP DESIGN - CLOSURE SO JOURNAL OF HYDRAULIC ENGINEERING-ASCE LA English DT Discussion RP MAYNORD, ST (reprint author), USA ENGN,WATERWAYS EXPT STN,HYDR LAB,POB 631,VICKSBURG,MS 39180, USA. NR 2 TC 0 Z9 0 U1 0 U2 1 PU ASCE-AMER SOC CIVIL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-9429 J9 J HYDRAUL ENG-ASCE JI J. Hydraul. Eng.-ASCE PD APR PY 1991 VL 117 IS 4 BP 542 EP 544 DI 10.1061/(ASCE)0733-9429(1991)117:4(542.3) PG 3 WC Engineering, Civil; Engineering, Mechanical; Water Resources SC Engineering; Water Resources GA FD066 UT WOS:A1991FD06600014 ER PT J AU TACKET, CO LOSONSKY, G TAYLOR, DN BARON, LS KOPECKO, D CRYZ, S LEVINE, MM AF TACKET, CO LOSONSKY, G TAYLOR, DN BARON, LS KOPECKO, D CRYZ, S LEVINE, MM TI LACK OF IMMUNE-RESPONSE TO THE VI COMPONENT OF A VI-POSITIVE VARIANT OF THE SALMONELLA-TYPHI LIVE ORAL VACCINE STRAIN TY21A IN HUMAN STUDIES SO JOURNAL OF INFECTIOUS DISEASES LA English DT Note ID IMMUNOGENICITY; CARRIERS; MUTANT; SAFETY; FEVER AB New typhoid vaccines have been sought to replace the reactogenic parenteral whole cell vaccines. Both Ty21a, a live oral attenuated Vi-negative Salmonella typhi vaccine strain, and parenteral Vi polysaccharide vaccine are safe and efficacious in field trials. To achieve potentially greater protective efficacy, a derivative of Ty21a that expresses Vi polysaccharide was prepared and its safety and immunogenicity assessed in 27 adult volunteers. The volunteers received either one dose of 5 x 10(5), 5 x 10(7), or 5 x 10(9) cfu or three doses of 5 x 10(9) cfu of lyophilized vaccine and were observed for adverse effects on a research isolation ward. The vaccine was well tolerated; however, at the highest dose, 13% of volunteers had mild diarrhea. Serial blood cultures were negative for the vaccine strain. Vaccine was shed in the stool of most volunteers at the higher doses for 1-4 days. No serum antibodies to Vi, circulating cells secreting antibody to Vi, or jejunal fluid antibodies to Vi were detected in any volunteer. C1 WALTER REED ARMY MED CTR,DEPT MICROBIOL & IMMUNOL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT BACTERIAL DIS,WASHINGTON,DC 20307. SWISS SERUM & VACCINE INST,BERN,SWITZERLAND. RP TACKET, CO (reprint author), UNIV MARYLAND,SCH MED,DEPT MED,CTR VACCINE DEV,10 S PINE ST,BALTIMORE,MD 21201, USA. NR 15 TC 25 Z9 25 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD APR PY 1991 VL 163 IS 4 BP 901 EP 904 PG 4 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA FD939 UT WOS:A1991FD93900042 PM 2010645 ER PT J AU DOMLOGEHULTSCH, N BENSON, P GAMMON, WR YANCEY, KB AF DOMLOGEHULTSCH, N BENSON, P GAMMON, WR YANCEY, KB TI AN ATYPICAL BULLOUS SKIN-DISEASE (BSD) PATIENT WITH ANTIBASEMENT MEMBRANE ZONE (BMZ) ANTIBODIES RECOGNIZING SEPARATE EPITOPES IN 1M NACL SPLIT SKIN (SSS) SO JOURNAL OF INVESTIGATIVE DERMATOLOGY LA English DT Meeting Abstract C1 UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. UNIV N CAROLINA,CHAPEL HILL,NC 27514. NR 0 TC 0 Z9 0 U1 0 U2 0 PU BLACKWELL PUBLISHING INC PI MALDEN PA 350 MAIN ST, MALDEN, MA 02148 USA SN 0022-202X J9 J INVEST DERMATOL JI J. Invest. Dermatol. PD APR PY 1991 VL 96 IS 4 BP 553 EP 553 PG 1 WC Dermatology SC Dermatology GA FE591 UT WOS:A1991FE59100154 ER PT J AU LEYDEN, JJ MCGINLEY, KJ SMITH, KJ JAMES, WD AF LEYDEN, JJ MCGINLEY, KJ SMITH, KJ JAMES, WD TI STAPHYLOCOCCUS-AUREUS COLONIZATION OF MULTIPLE SITES IN HIV POSITIVE PATIENTS SO JOURNAL OF INVESTIGATIVE DERMATOLOGY LA English DT Meeting Abstract C1 UNIV PENN,SCH MED,DEPT DERMATOL,PHILADELPHIA,PA 19104. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 4 Z9 4 U1 0 U2 0 PU BLACKWELL PUBLISHING INC PI MALDEN PA 350 MAIN ST, MALDEN, MA 02148 USA SN 0022-202X J9 J INVEST DERMATOL JI J. Invest. Dermatol. PD APR PY 1991 VL 96 IS 4 BP 572 EP 572 PG 1 WC Dermatology SC Dermatology GA FE591 UT WOS:A1991FE59100271 ER PT J AU KLAYMAN, DL LIN, AJ MCCALL, JW WANG, SY TOWNSON, S GROGL, M KINNAMON, KE AF KLAYMAN, DL LIN, AJ MCCALL, JW WANG, SY TOWNSON, S GROGL, M KINNAMON, KE TI 2-ACETYLPYRIDINE THIOSEMICARBAZONES .13. DERIVATIVES WITH ANTIFILARIAL ACTIVITY SO JOURNAL OF MEDICINAL CHEMISTRY LA English DT Article ID ANTI-MALARIAL AGENTS; ONCOPELTUS-FASCIATUS; INHIBITORS; INVITRO; ECDYSIS; MODEL AB Several members of a series of 2-acetylpyridine thiosemicarbazones possess in vivo and in vitro macrofilaricidal properties. The most promising of the group tested is N4-(2-aminophenyl)-2-[1-(2-pyridinyl)ethylidene]-hydrazinecarbothioamide (4), which suppressed 100% of the macrofilariae of Brugia pahangi and 94% of those of Acanthocheilonema viteae in the jird at a dose of 25 mg/kg per day x 5. Compounds 4 and 14 were also shown to inactivate or kill Onchocerca gutturosa and Onchocerca volvulus adult worms as measured by the loss of their motility or the inhibition of the conversion by the worms of the dye MTT to formazan. C1 UNIV GEORGIA,COLL VET MED,ATHENS,GA 30602. CAB INT INST PARASITOL,ST ALBANS AL4 0XU,ENGLAND. UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. RP KLAYMAN, DL (reprint author), WALTER REED ARMY MED CTR,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307, USA. NR 16 TC 22 Z9 22 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0022-2623 J9 J MED CHEM JI J. Med. Chem. PD APR PY 1991 VL 34 IS 4 BP 1422 EP 1425 DI 10.1021/jm00108a027 PG 4 WC Chemistry, Medicinal SC Pharmacology & Pharmacy GA FG776 UT WOS:A1991FG77600027 PM 2016717 ER PT J AU GLANTZ, DM AF GLANTZ, DM TI OBSERVING THE SOVIETS - U.S.-ARMY ATTACHES IN EASTERN-EUROPE DURING THE 1930S SO JOURNAL OF MILITARY HISTORY LA English DT Article RP GLANTZ, DM (reprint author), USA,CTR COMBINED ARMS,SOVIET ARMY STUDIES OFF,FT LEAVENWORTH,KS 66027, USA. NR 55 TC 1 Z9 1 U1 0 U2 0 PU VIRGINIA MILITARY INST PI LEXINGTON PA LEXINGTON, VA 24450 SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD APR PY 1991 VL 55 IS 2 BP 153 EP 183 DI 10.2307/1985893 PG 31 WC History SC History GA FH415 UT WOS:A1991FH41500002 ER PT J AU DREA, EJ AF DREA, EJ TI READING EACH OTHERS MAIL - JAPANESE COMMUNICATION INTELLIGENCE, 1920-1941 SO JOURNAL OF MILITARY HISTORY LA English DT Article RP DREA, EJ (reprint author), USA,CTR MIL HIST,STAFF SUPPORT BRANCH,WASHINGTON,DC 20310, USA. NR 34 TC 2 Z9 2 U1 0 U2 0 PU VIRGINIA MILITARY INST PI LEXINGTON PA LEXINGTON, VA 24450 SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD APR PY 1991 VL 55 IS 2 BP 185 EP 205 DI 10.2307/1985894 PG 21 WC History SC History GA FH415 UT WOS:A1991FH41500003 ER PT J AU COOPER, J AF COOPER, J TI SOLDIERS AND SCHOLARS - THE US-ARMY AND THE USES OF MILITARY HISTORY 1865-1920 - REARDON,C SO JOURNAL OF MILITARY HISTORY LA English DT Book Review RP COOPER, J (reprint author), USA,INST MIL HIST,WASHINGTON,DC 20310, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU VIRGINIA MILITARY INST PI LEXINGTON PA LEXINGTON, VA 24450 SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD APR PY 1991 VL 55 IS 2 BP 257 EP 258 DI 10.2307/1985915 PG 2 WC History SC History GA FH415 UT WOS:A1991FH41500025 ER PT J AU GLANTZ, DM AF GLANTZ, DM TI ICEBREAKER - WHO STARTED WORLD-WAR-II - SUVOROV,V SO JOURNAL OF MILITARY HISTORY LA English DT Book Review RP GLANTZ, DM (reprint author), USA,CTR COMBINED ARMS,SOVIET ARMY STUDIES OFF,FT LEAVENWORTH,KS 66027, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU VIRGINIA MILITARY INST PI LEXINGTON PA LEXINGTON, VA 24450 SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD APR PY 1991 VL 55 IS 2 BP 263 EP 264 DI 10.2307/1985920 PG 2 WC History SC History GA FH415 UT WOS:A1991FH41500030 ER PT J AU DURIG, JR GEYER, TJ KIM, YH KALASINSKY, VF MCDONALD, JK AF DURIG, JR GEYER, TJ KIM, YH KALASINSKY, VF MCDONALD, JK TI FAR-INFRARED SPECTRA AND ABINITIO CALCULATIONS OF NITROSYL CHLORIDE SO JOURNAL OF MOLECULAR STRUCTURE LA English DT Article ID CONSTANTS; FIELD AB The far-infrared spectra of (ON35Cl)-Cl-35 and (ON37Cl)-Cl-37 were recorded from 20 to 100 cm-1 at a resolution of 0.004 cm-1. Thirteen pure rotational Q branches were assigned for each molecule in the ground vibrational state from which the rotational constants A and the distortion constants DELTA-K and phi-K were obtained utilizing previously reported values of the constants B and C from microwave studies. Rotational Q branches were also observed for both molecules in two vibrationally excited states. Ab initio calculations up to those using fourth-order perturbation (MP4) with configuration interaction utilizing the 6-31G* basis set were carried out. Optimized geometries obtained at this level are compared with those obtained with smaller basis sets without configuration interaction and with the experimentally determined values. Force constants were calculated which are compared with the values previously reported. The potential energy distributions and quartic distortion constants were obtained at all levels of ab initio calculations up to MP2/6-31G*. C1 MISSISSIPPI STATE UNIV,DEPT CHEM,MISSISSIPPI STATE,MS 39762. USA,MISSILE COMMAND,AMSMI RD RE QP,REDSTONE ARSENAL,AL 35898. RP DURIG, JR (reprint author), UNIV S CAROLINA,DEPT CHEM,COLUMBIA,SC 29208, USA. NR 18 TC 12 Z9 12 U1 1 U2 4 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-2860 J9 J MOL STRUCT JI J. Mol. Struct. PD APR PY 1991 VL 244 BP 103 EP 115 DI 10.1016/0022-2860(91)80151-S PG 13 WC Chemistry, Physical SC Chemistry GA FH594 UT WOS:A1991FH59400009 ER PT J AU TAYLOR, T HAWKINS, DR FORREST, TJ CHUNG, H AF TAYLOR, T HAWKINS, DR FORREST, TJ CHUNG, H TI PHARMACOKINETICS OF PYRIDOSTIGMINE IN DOGS SO JOURNAL OF PHARMACEUTICAL SCIENCES LA English DT Article ID PROTECTION; PRETREATMENT; DRUG; NEOSTIGMINE; PLASMA; SOMAN; TIME AB The pharmacokinetics of the cholinesterase inhibitor pyridostigmine has been studied in six male Beagle dogs after iv infusion and after oral doses as an immediate-release syrup and as an extended-release tablet, all at a level of approximately 0.6 mg/kg. Pyridostigmine was characterized as a drug of relatively long terminal half-life (8.3 h +/- 2.1 SD), low systemic clearance (13 mL/min/kg +/- 1 SD) and high volumes of distribution (Vd-lambda-z, 8.7 L/kg +/- 1.9 SD and Vd(ss), 3.9 L/kg +/- 0.9 SD). The ratio of mean residence times in tissues and plasma was > 4, indicating a high affinity of peripheral tissues for the drug. This ratio was about twofold higher in three of the dogs than in the others. Pyridostigmine was slowly and incompletely bioavailable in these dogs; the systemic availability was 44.4% +/- 4.3 SD from the syrup and 33.6% +/- 9.5 SD from the tablet. Pyridostigmine disposition in these dogs was largely determined by distribution processes. C1 WALTER REED ARMY MED CTR,DIV EXPT THERAPEUT,WASHINGTON,DC 20307. RP TAYLOR, T (reprint author), HUNTINGDON RES CTR,DEPT METAB & PHARMACOKINET,HUNTINGDON PE18 6ES,CAMBS,ENGLAND. NR 21 TC 7 Z9 7 U1 0 U2 0 PU AMER PHARMACEUTICAL ASSN PI WASHINGTON PA 2215 CONSTITUTION AVE NW, WASHINGTON, DC 20037 SN 0022-3549 J9 J PHARM SCI JI J. Pharm. Sci. PD APR PY 1991 VL 80 IS 4 BP 353 EP 356 DI 10.1002/jps.2600800414 PG 4 WC Chemistry, Medicinal; Chemistry, Multidisciplinary; Pharmacology & Pharmacy SC Pharmacology & Pharmacy; Chemistry GA FF977 UT WOS:A1991FF97700013 PM 1865335 ER PT J AU LANKFORD, RJ CHRISTENSEN, LC AF LANKFORD, RJ CHRISTENSEN, LC TI PIN-RETAINED, RESIN-BONDED FIXED PARTIAL DENTURES SO JOURNAL OF PROSTHETIC DENTISTRY LA English DT Article AB This article describes a technique to enhance resistance form in the construction of anterior resin-bonded fixed partial dentures. The technique is simple and conserves tooth structure. It uses a cingulum pin when an opposing axial groove cannot be adequately incorporated into the preparation. C1 USA,DENT CORPS,WASHINGTON,DC 20310. NR 3 TC 5 Z9 6 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0022-3913 J9 J PROSTHET DENT JI J. Prosthet. Dent. PD APR PY 1991 VL 65 IS 4 BP 469 EP 470 DI 10.1016/0022-3913(91)90280-A PG 2 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA FE185 UT WOS:A1991FE18500003 PM 2066879 ER PT J AU DRISCOLL, CF WOOLSEY, G FERGUSON, WM AF DRISCOLL, CF WOOLSEY, G FERGUSON, WM TI COMPARISON OF EXOTHERMIC RELEASE DURING POLYMERIZATION OF 4 MATERIALS USED TO FABRICATE INTERIM RESTORATIONS SO JOURNAL OF PROSTHETIC DENTISTRY LA English DT Article ID TEMPORARY AB Four materials commonly used to make resin crown and fixed partial denture interim restorations (poly)methylmethacrylate, vinyl ethylmethacrylate, visible-light activated resin, and a Bis-acryl composite resin) were studied to evaluate their heat-producing capabilities. All four materials, despite manufacturers' claims, created a rise in temperature during polymerization. Poly(methylmethacrylate)'s temperature increases were significantly higher than those of the other three materials and visible-light activated resin had temperature increases that were significantly lower than those of the other three products. Dentists must be aware of all potential heat-producing sources to minimize thermal injury to the hard and soft tissues of the oral cavity during the fabrication of interim crowns and fixed partial dentures. C1 USA,PROSTHODONT,FT LEAVENWORTH,MS. USA,PROSTHODONT,FT HOOD,TX. NR 8 TC 21 Z9 23 U1 2 U2 2 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0022-3913 J9 J PROSTHET DENT JI J. Prosthet. Dent. PD APR PY 1991 VL 65 IS 4 BP 504 EP 506 DI 10.1016/0022-3913(91)90289-9 PG 3 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA FE185 UT WOS:A1991FE18500012 PM 2066887 ER PT J AU ADRIAN, ED KRANTZ, WA IVANHOE, JR TURNER, KA AF ADRIAN, ED KRANTZ, WA IVANHOE, JR TURNER, KA TI A SILICONE OBTURATOR FOR THE ACCESS CANAL IN AN IMPLANT-RETAINED FIXED PROSTHESIS SO JOURNAL OF PROSTHETIC DENTISTRY LA English DT Article C1 USA,REMOVABLE PROSTHODONT SERV,FT GORDON,GA 30905. USA,PROSTHODONT RESIDENCY PROGRAM,FT GORDON,GA 30905. EMORY UNIV,SCH POSTGRAD DENT,DENT PROSTHODONT,ATLANTA,GA 30322. NR 1 TC 8 Z9 8 U1 0 U2 1 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0022-3913 J9 J PROSTHET DENT JI J. Prosthet. Dent. PD APR PY 1991 VL 65 IS 4 BP 597 EP 597 DI 10.1016/0022-3913(91)90306-H PG 1 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA FE185 UT WOS:A1991FE18500029 PM 2066903 ER PT J AU PLUMMER, KD AF PLUMMER, KD TI TECHNIQUE TO AID IN FABRICATION OF RADIATION CARRIERS SO JOURNAL OF PROSTHETIC DENTISTRY LA English DT Article C1 USA,FT HOOD,TX. NR 2 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0022-3913 J9 J PROSTHET DENT JI J. Prosthet. Dent. PD APR PY 1991 VL 65 IS 4 BP 600 EP 600 DI 10.1016/0022-3913(91)90308-J PG 1 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA FE185 UT WOS:A1991FE18500031 PM 2066905 ER PT J AU STILES, BG MIDDLEBROOK, JL AF STILES, BG MIDDLEBROOK, JL TI EPITOPE MAPPING OF SNAKE-VENOM PHOSPHOLIPASES-A2 WITH PSEUDEXIN MONOCLONAL-ANTIBODIES SO JOURNAL OF PROTEIN CHEMISTRY LA English DT Article DE PHOSPHOLIPASE-A2; EPITOPE MAPPING; CROSS-REACTIVITY; MONOCLONAL ANTIBODIES ID BELLIED BLACK SNAKE; AMINO-ACID; PSEUDECHIS-PORPHYRIACUS; CRYSTAL-STRUCTURE; CROTALUS-ATROX; RESOLUTION; SEQUENCE; SUBUNIT; EVOLUTIONARY; NEUROTOXINS AB Fifteen different monoclonal antibodies, developed against a pseudexin A, B, and C mixture, were screened for linear epitope recognition. Peptides (9-mers) spanning pseudexin B were synthesized on alanine-derivatized polyethylene pins and subsequently probed with antibody. Four antibodies recognized linear epitopes of pseudexin A, pseudexin B, and also nonidentical sequences found in other phospholipases A2 (PLA2s) as determined by enzyme-linked immunosorbent assays. Three antibodies recognized a highly conserved site important in calcium binding and the interlocking of dimeric forms of PLA2. Antibodies neutralizing lethal or enzymatic effects of PLA2 did not recognize linear epitopes. RP STILES, BG (reprint author), USA,MED RES INST INFECT DIS,DIV PATHOPHYSIOL,DEPT TOXINOL,FREDERICK,MD 21701, USA. NR 31 TC 6 Z9 6 U1 0 U2 0 PU PLENUM PUBL CORP PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 SN 0277-8033 J9 J PROTEIN CHEM JI J. Protein Chem. PD APR PY 1991 VL 10 IS 2 BP 193 EP 204 DI 10.1007/BF01024784 PG 12 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA FN776 UT WOS:A1991FN77600009 PM 1718309 ER PT J AU PETRALI, JP MAXWELL, DM LENZ, DE MILLS, KR AF PETRALI, JP MAXWELL, DM LENZ, DE MILLS, KR TI EFFECT OF AN ANTICHOLINESTERASE COMPOUND ON THE ULTRASTRUCTURE AND FUNCTION OF THE RAT BLOOD-BRAIN-BARRIER - A REVIEW AND EXPERIMENT SO JOURNAL OF SUBMICROSCOPIC CYTOLOGY AND PATHOLOGY LA English DT Review DE ANTICHOLINESTERASE; BLOOD-BRAIN BARRIER; ENDOTHELIAL CELL; ULTRASTRUCTURE ID CHOLINESTERASE; ANTIBODIES; TRANSPORT AB Soman, an organophosphorous irreversible inhibitor of acetylcholinesterase, was studied for its effect on the rat blood-brain barrier (BBB) during the first 24 h of intoxication. Young adult male Sprague-Dawley rats, injected with Evans blue-dye and surviving a subsequent single convulsive dose of soman (114-mu-g/kg, 0.9LD50), presented focal and diffuse penetration of dye in areas of brain normally considered protected by the BBB. Invasion was widest during the first hour when signs of excitation, respiratory distress and convulsions peaked and was absent at 24 h. During this time period, cholinesterase inhibition, as measured by enzyme assay, persisted in brain and blood at 10% and 6% of control values respectively. Brains of nonconvulsing animals and animals pretreated with nembutal (45 mg/kg, I.P.) or with diazepam (10 mg/kg, I.P.) were free of extravasated dye. A ranking of dye-breached brain areas suggested that cerebellar and cerebral cortex were most frequently involved while brain stem was rarely stained. Ultrastructural analysis of breached areas with horseradish peroxidase as a tracer molecule, revealed that the probable subcellular mechanism of the induced breach was enhanced vesicular transport, a mechanism similarly described for seizure. Consequences of the breach were emphasized with the detection of significantly elevated levels of an exogenously administered quaternary compound, 3H-hexamethonium. These findings present additional evidence that an anticholinesterase-induced breach of the rat blood-brain barrier is convulsive dependent, demonstrates BBB mechanisms similar to that of seizure, and can allow CNS penetration of blood-borne drugs and circulatory proteins that normally would be slowed or excluded by an intact BBB. A brief review of the known effects of anticholinesterase compounds on the BBB is presented in the introduction. RP PETRALI, JP (reprint author), USA,MRICD,COMPARAT PATHOL BRANCH,BIOCHEM & PHARMACOL BRANCH,ABERDEEN PROVING GROUND,MD, USA. NR 15 TC 37 Z9 37 U1 1 U2 2 PU EDITRICE COMPOSITORI BOLOGNA PI BOLOGNA PA VIA STALINGRADO 97/2, I-40128 BOLOGNA, ITALY SN 1122-9497 J9 J SUBMICR CYTOL PATH JI J. Submicrosc. Cytol. Pathol. PD APR PY 1991 VL 23 IS 2 BP 331 EP 338 PG 8 WC Pathology SC Pathology GA FH458 UT WOS:A1991FH45800018 PM 2070359 ER PT J AU SCHOMER, PD BUCHTA, E HIRSCH, KW AF SCHOMER, PD BUCHTA, E HIRSCH, KW TI DECIBEL ANNOYANCE REDUCTION OF LOW-FREQUENCY BLAST ATTENUATING WINDOWS SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA LA English DT Article ID HUMAN RESPONSE; NOISE AB In this study, the acoustical benefits of improved, blast noise reducing retrofit windows are determined using the methods of paired-comparison testing with panels of subjects. The results show that the retrofit windows reduce the received indoor C-weighted SEL by about 7 dB. The retrofit windows result in about a 14-dB improvement in terms of community response. Further, a regression line is fit to the indoor measured blast CSEL and their correspondingly equivalent control noise ASEL. The slope of this line is 2.5, indicating that a 1-dB change in CSEL corresponds to about 2.5-dB change in control ASEL. This corresponds to the result one would get if one used loudness to describe both indoor signals instead of describing the control (indoors) using ASEL and the blast (outdoors) using a variety of descriptors such as peak, CSEL or FSEL, etc. C1 INST LARMSCHUTZ,DUSSELDORF,GERMANY. RP SCHOMER, PD (reprint author), USA,CONSTRUCT ENGN RES LABS,CHAMPAIGN,IL 61820, USA. NR 12 TC 2 Z9 2 U1 0 U2 2 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0001-4966 J9 J ACOUST SOC AM JI J. Acoust. Soc. Am. PD APR PY 1991 VL 89 IS 4 BP 1708 EP 1713 DI 10.1121/1.401004 PN 1 PG 6 WC Acoustics; Audiology & Speech-Language Pathology SC Acoustics; Audiology & Speech-Language Pathology GA FE640 UT WOS:A1991FE64000020 ER PT J AU SOLANA, RP GENNINGS, C CARTER, WH ANDERSON, D LENNOX, WJ CARCHMAN, RA HARRIS, LW AF SOLANA, RP GENNINGS, C CARTER, WH ANDERSON, D LENNOX, WJ CARCHMAN, RA HARRIS, LW TI EFFICACY COMPARISON OF 2 CHOLINOLYTICS, SCOPOLAMINE AND AZAPROPHEN, WHEN USED IN CONJUNCTION WITH PHYSOSTIGMINE AND PYRIDOSTIGMINE FOR PROTECTION AGAINST ORGANOPHOSPHATE EXPOSURE SO JOURNAL OF THE AMERICAN COLLEGE OF TOXICOLOGY LA English DT Article ID SOMAN; INHIBITION; SECRETION; ATROPINE AB Pretreatment with either pyridostigmine (PYR) or physostigmine (PHY) followed by atropine-oxime therapy is very effective in reducing the lethality of organophosphorus nerve agents. The therapeutic efficacy of scopolamine (SCP) versus azaprophen (AZA), when used in conjunction with PHY and PYR (PHY/PYR) combination pretreatment, was evaluated in guinea pigs challenged with 2 half-lethal doses of soman. Maximum postsoman decrement of rotarod performance was measured. Response surface methodology was employed to describe the relationship between the decrement and the PHY/PYR dosages. Results show that AZA is a more effective pretreatment adjunct at the behavioral deficit-free doses tested, AZA or SCP is as effective with PHY alone as with a PHY/PYR combination. Thus, PYR adds essentially nothing to the carbamate combination against soman-induced behavioral deficit. C1 VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,DEPT BIOSTAT,RICHMOND,VA 23298. VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,DEPT PHARMACOL TOXICOL,RICHMOND,VA 23298. RP SOLANA, RP (reprint author), USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010, USA. NR 14 TC 5 Z9 5 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0730-0913 J9 J AM COLL TOXICOL JI J. Am. Coll. Toxicol. PD APR PY 1991 VL 10 IS 2 BP 215 EP 222 PG 8 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA GN779 UT WOS:A1991GN77900001 ER PT J AU ORMISTON, RA AF ORMISTON, RA TI ROTOR-FUSELAGE DYNAMICS OF HELICOPTER AIR AND GROUND RESONANCE SO JOURNAL OF THE AMERICAN HELICOPTER SOCIETY LA English DT Article AB An analytical investigation of the air- and ground-resonance characteristics of simplified hingeless-rotor helicopter configurations was undertaken. The objectives were to identify and interpret the unique characteristics of coupled rotor-body modes that determine air-resonance stability characteristics, as contrasted to ground-resonance phenomena. The study examined the influence on air-resonance stability of unusual rotor-body modal characteristics such as nonoscillatory body modes. The results indicate that air-resonance instability does not require distinct coalescences of lead-lag and rotor-body modal frequencies, and unusual rotor-body frequency characteristics do not significantly alter the occurrence of air-resonance instability or the effectiveness of aeroelastic couplings. The character of air-resonance and flap-lag instabilities was found to change significantly at high rotor speeds for high-Lock number and low-inertia configurations. It was found that the rotor-body modes that participate in both air and ground resonance can be related to one another. RP ORMISTON, RA (reprint author), USA,AEROFLIGHTDYNAM DIRECTORATE,AVSCOM,DIV ROTORCRAFT DYNAM,MOFFETT FIELD,CA, USA. NR 18 TC 8 Z9 10 U1 0 U2 0 PU AMER HELICOPTER SOC INC PI ALEXANDRIA PA 217 N WASHINGTON ST, ALEXANDRIA, VA 22314 SN 0002-8711 J9 J AM HELICOPTER SOC JI J. Am. Helicopter Soc. PD APR PY 1991 VL 36 IS 2 BP 3 EP 20 PG 18 WC Engineering, Aerospace SC Engineering GA FK440 UT WOS:A1991FK44000001 ER PT J AU KRASNOWSKI, BR ROTENBERGER, KM SPENCE, WW AF KRASNOWSKI, BR ROTENBERGER, KM SPENCE, WW TI A DAMAGE TOLERANCE METHOD FOR HELICOPTER DYNAMIC COMPONENTS SO JOURNAL OF THE AMERICAN HELICOPTER SOCIETY LA English DT Article AB The helicopter community's growing interest in damage tolerance design and substantiation stems from existing military requirements and new commercial requirements. This interest is reinforced by the successful application of damage tolerance philosophy to fixed-wing structures. Experience in damage tolerance comes mainly from its application to the simple geometries of cracks in large, thin shells, which are common for fixed-wing structures, ship's hulls, and pressure vessels. Rigorous application of damage tolerance methodology to complex structural geometry and complex loading, which are characteristic of helicopter components, requires expensive and time-consuming research and development efforts. This paper presents a simplified engineering approach to damage tolerance substantiation of metallic structures based on the concept of equivalent structure. This approach allows the user of replace complex structures, their loadings, the geometry of the crack plane and the crack itself with simplified counterparts for which the elements of the crack growth model are known, documented, and verified. One result of using the simplification criteria is moderate conservatism in the crack growth predictions. The proposed approach is illustrated by its application to the analysis of a rod end bearing housing for the AH-1S main rotor pitch link. Crack growth testing was conducted for the critical cross sections, which were identified by analysis. The predicted crack growth was verified by the tests. C1 USA,AVIAT SYST COMMAND,ST LOUIS,MO. RP KRASNOWSKI, BR (reprint author), BELL HELICOPTER TEXTRON INC,FT WORTH,TX 76101, USA. NR 26 TC 5 Z9 5 U1 0 U2 0 PU AMER HELICOPTER SOC INC PI ALEXANDRIA PA 217 N WASHINGTON ST, ALEXANDRIA, VA 22314 SN 0002-8711 J9 J AM HELICOPTER SOC JI J. Am. Helicopter Soc. PD APR PY 1991 VL 36 IS 2 BP 52 EP 60 PG 9 WC Engineering, Aerospace SC Engineering GA FK440 UT WOS:A1991FK44000005 ER PT J AU BUEHLER, DA MERSMANN, TJ FRASER, JD SEEGAR, JKD AF BUEHLER, DA MERSMANN, TJ FRASER, JD SEEGAR, JKD TI NONBREEDING BALD EAGLE COMMUNAL AND SOLITARY ROOSTING BEHAVIOR AND ROOST HABITAT ON THE NORTHERN CHESAPEAKE BAY SO JOURNAL OF WILDLIFE MANAGEMENT LA English DT Article ID NORTHWEST; OREGON AB We studied roosting behavior and habitat use of nonbreeding bald eagles (Haliaeetus leucocephalus) on the northern Chesapeake Bay during 1986-89. In summer and winter, 11 and 13 communal roosts, respectively, and many solitary roosts were used simultaneously in the 3,426-km2 study area. Radio-tagged eagles roosted solitarily with differing frequency by season (60, 21, 39, and 44% of 81 eagle nights in summer, fall, winter, and spring, respectively) (P < 0.05). Roost trees, predominantly oaks (Quercus spp.) or yellow poplars (Liriodendron tulipifera), were larger in diameter and provided greater conopy cover than random trees (P < 0.05). Roost sites had snags present more often than did random sites (P < 0.01). Most roosts (86%) were in woodlots > 40 ha, and none were in human-developed habitat. In contrast, only 23% of random sites were in woodlots > 40 ha, and 9% were in developed areas. Roosts were farther from human development than were random sites (P < 0.05); 57% of the roosts were found on public lands, compared to only 20% of the random sites (P < 0.001). Winter roost sites were protected from prevailing northerly winds more often than were summer sites (P < 0.05). We prescribe a 1,360-m-wide shoreline management zone that extends 1,400 m inland to encompass roost sites and provide a buffer from human disturbance. C1 VIRGINIA POLYTECH INST & STATE UNIV,DEPT FISHERIES & WILDLIFE SCI,BLACKSBURG,VA 24061. USA,CTR CHEM RES DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010. NR 22 TC 18 Z9 18 U1 0 U2 3 PU WILDLIFE SOC PI BETHESDA PA 5410 GROSVENOR LANE, BETHESDA, MD 20814-2197 SN 0022-541X J9 J WILDLIFE MANAGE JI J. Wildl. Manage. PD APR PY 1991 VL 55 IS 2 BP 273 EP 281 DI 10.2307/3809150 PG 9 WC Ecology; Zoology SC Environmental Sciences & Ecology; Zoology GA FL596 UT WOS:A1991FL59600010 ER PT J AU BUEHLER, DA MERSMANN, TJ FRASER, JD SEEGAR, JKD AF BUEHLER, DA MERSMANN, TJ FRASER, JD SEEGAR, JKD TI EFFECTS OF HUMAN ACTIVITY ON BALD EAGLE DISTRIBUTION ON THE NORTHERN CHESAPEAKE BAY SO JOURNAL OF WILDLIFE MANAGEMENT LA English DT Article ID RESPONSES AB We determined the relationship between bald eagle (Haliaeetus leucocephalus) distribution and human activity on the northern Chesapeake Bay shoreline during 1985-89. Only 55 of 1,117 locations of radio-tagged eagles (4.9%) occurred in the developed land-cover type (greater-than-or-equal-to 4 buildings/4 ha), although 18.2% of potential eagle habitat was developed (chi-2 = 428.9, 4 df, P < 0.001). Eagle use of the shoreline was inversely related to building density (chi-2 = 22.1, P < 0.001) and directly related to the development set-back distance (chi-2 = 5.3, P = 0.02). Few eagles used shoreline segments with boats or pedestrians nearby (P < 0.001). Only 360 of 2,532 segments (14.2%) had neither human activity nor shoreline development. Eagle flush distances because of approaching boats were greater in winter than in summer (xBAR = 264.9 vs. 175.5 m, respectively, P = 0.001), but were similar for adult and immature eagles (xBAR = 203.7 vs. 228.6 m, respectively, P = 0.38). Of 2,472 km of shoreline on the northern Chesapeake, 894 km (36.2%) appears to be too developed to be suitable for eagle use, and an additional 996 km (40.3%) had buildings within 500 m, thereby reducing eagle use. The projected increase in developed land in Maryland (74%) and Virginia (80%) from 1978 to 2020 is likely to determine the future of the bald eagle population on the northern Chesapeake Bay. C1 VIRGINIA POLYTECH INST & STATE UNIV,DEPT FISHERIES & WILDLIFE SCI,BLACKSBURG,VA 24061. USA,CTR CHEM RES DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010. NR 9 TC 33 Z9 34 U1 0 U2 16 PU WILDLIFE SOC PI BETHESDA PA 5410 GROSVENOR LANE, BETHESDA, MD 20814-2197 SN 0022-541X J9 J WILDLIFE MANAGE JI J. Wildl. Manage. PD APR PY 1991 VL 55 IS 2 BP 282 EP 290 DI 10.2307/3809151 PG 9 WC Ecology; Zoology SC Environmental Sciences & Ecology; Zoology GA FL596 UT WOS:A1991FL59600011 ER PT J AU PERLSTEIN, RS MOUGEY, EH JACKSON, WE NETA, R AF PERLSTEIN, RS MOUGEY, EH JACKSON, WE NETA, R TI INTERLEUKIN-1 AND INTERLEUKIN-6 ACT SYNERGISTICALLY TO STIMULATE THE RELEASE OF ADRENOCORTICOTROPIC HORMONE INVIVO SO LYMPHOKINE AND CYTOKINE RESEARCH LA English DT Article ID PITUITARY-TUMOR CELLS; FREELY-MOVING RATS; INTRACEREBROVENTRICULAR INJECTION; RECOMBINANT INTERLEUKIN-1; IMMUNOREGULATORY FEEDBACK; GLUCOCORTICOID HORMONES; MULTIPLE HORMONES; IL-1; SECRETION; GROWTH AB Interleukin-1 (IL-1) and interleukin-6 (IL-6) share a number of biological functions. Because IL-1 induces IL-6 in vivo, the extent to which IL-6 mediates the effects of IL-1 has come under investigation. The stimulation of the hypothalamic-pituitary-adrenal axis by IL-1 and IL-6 is a critical component of the inflammatory response. The present study was designed to compare the effects of recombinant human IL-1-alpha (rhIL-1-alpha) and recombinant human IL-6 (rhIL-6) administered in combination and alone on the release of adrenocorticotropic hormone (ACTH) in mice. We have demonstrated that the administration of rhIL-6 alone does not duplicate the stimulatory effect of rhIL-1-alpha on ACTH release. On the other hand, suboptimal amounts of rhIL-1-alpha and rhIL-6 synergize to induce an early (30-60 min) ACTH response and produce a later (2-3 h) response that is similar to the one observed after rhIL-1-alpha is administered alone. These results suggest that the 2-3 h response to rhIL-1-alpha may be dependent on synergy with the endogenous IL-6 it induces systemically and in the central nervous system (including the hypothalamus and the pituitary gland). C1 WALTER REED ARMY MED CTR,DEPT MED NEUROSCI,NEUROENDOCRINOL & NEUROCHEM BRANCH,WASHINGTON,DC 20307. RP PERLSTEIN, RS (reprint author), ARMED FORCES RADIOBIOL RES INST,DEPT EXPTL HEMATOL,BETHESDA,MD 20889, USA. NR 50 TC 81 Z9 82 U1 0 U2 1 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0277-6766 J9 LYMPHOKINE CYTOK RES JI Lymphokine Cytokine Res. PD APR PY 1991 VL 10 IS 1-2 BP 141 EP 146 PG 6 WC Biochemistry & Molecular Biology; Immunology SC Biochemistry & Molecular Biology; Immunology GA FL932 UT WOS:A1991FL93200022 PM 1651767 ER PT J AU KUMAR, A ODEH, A GHORBEL, F SPONG, M AF KUMAR, A ODEH, A GHORBEL, F SPONG, M TI ROBOTIC CORROSION INSPECTION CRAWLER SO MATERIALS PERFORMANCE LA English DT Article AB Inspection of corrosion damage to underground and building piping systems is required to make repair decisions. It is difficult to inspect and diagnose the outside of underground piping because the pipe is usually enclosed in casing or insulation. Emphasis of this research is on internal inspection and corrosion status assessment of gas, water, and steam pipes. Prototype designs of the robotic corrosion inspection crawler were investigated based on kinematic principles. The crawler is designed to negotiate right-angle turns and carry optical video and corrosion inspection probes. The crawler travels inside small-diameter pipes and automatically produces a permanent record of the corrosion status for further analysis and decision making. This article summarizes prototype designs and laboratory testing of the robotic corrosion inspection crawler system. RP KUMAR, A (reprint author), USA,CORPS ENGINEERS,CONSTRUCT ENGN RES LAB,POB 4005,CHAMPAIGN,IL 61824, USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU NATL ASSN CORROSION ENG PI HOUSTON PA 1440 SOUTH CREEK DRIVE, HOUSTON, TX 77084-4906 SN 0094-1492 J9 MATER PERFORMANCE JI Mater. Perform. PD APR PY 1991 VL 30 IS 4 BP 29 EP 32 PG 4 WC Materials Science, Characterization & Testing SC Materials Science GA FH568 UT WOS:A1991FH56800010 ER PT J AU ILBACK, NG FRIMAN, G CRAWFORD, DJ NEUFELD, HA AF ILBACK, NG FRIMAN, G CRAWFORD, DJ NEUFELD, HA TI EFFECTS OF TRAINING ON METABOLIC RESPONSES AND PERFORMANCE CAPACITY IN STREPTOCOCCUS-PNEUMONIAE INFECTED-RATS SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE LA English DT Article DE CARBOHYDRATE METABOLISM; ENDURANCE TRAINING; FAT METABOLISM; PERFORMANCE CAPACITY; PNEUMOCOCCAL INFECTION; RAT ID KETONE-BODY METABOLISM; SALMONELLA-TYPHIMURIUM; INSULIN SECRETION; SKELETAL-MUSCLE; ANTECEDENT DIET; EXERCISE; MYOCARDIUM; MICE; GLUCONEOGENESIS; STARVATION AB These experiments were designed to study whether endurance training prior to Streptococcus pneumoniae infection in rats (N = 15 in each group) alters lethality, performance capacity, and related energy metabolism. A 5-d.wk-1, 4-wk-long pre-infection training program with gradually increasing swim time caused no protection from lethality (48% at 72 h post-inoculation), but performance capacity increased by 68% (P < 0.01). The catabolic responses as evidenced by changes in insulin and glucagon levels were less pronounced. Mobilization of free fatty acids increased twofold (P < 0.01), and improved ketonemic adaptation (47%, P < 0.01) occurred with concomitant saved carcass, liver, and skeletal muscle glycogen contents (P < 0.01). This shift from carbohydrate toward fat metabolism during exercise as a result of training was also reflected by 21% lower (P < 0.01) blood lactate levels. It was concluded that the improved metabolic status, characterizing the trained as compared with the untrained host, is partly preserved during ongoing acute gram-positive bacterial infection. C1 USA,MED RES INST INFECT DIS,FREDERICK,MD 21701. UNIV UPPSALA,ACAD HOSP,DEPT INFECT DIS,S-75105 UPPSALA,SWEDEN. RP ILBACK, NG (reprint author), SWEDISH NATL FOOD ADM,TOXICOL LAB,POB 622,S-75126 UPPSALA,SWEDEN. NR 37 TC 18 Z9 18 U1 0 U2 1 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0195-9131 J9 MED SCI SPORT EXER JI Med. Sci. Sports Exerc. PD APR PY 1991 VL 23 IS 4 BP 422 EP 427 PG 6 WC Sport Sciences SC Sport Sciences GA FG529 UT WOS:A1991FG52900006 PM 2056899 ER PT J AU GELNOVATCH, VG AF GELNOVATCH, VG TI PROGNOSTICATIONS FROM THE EDGE SO MICROWAVE JOURNAL LA English DT Article RP GELNOVATCH, VG (reprint author), USA,LABCOM,ELECTR TECHNOL & DEVICES LAB,FT MONMOUTH,NJ 07703, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU HORIZON HOUSE-MICROWAVE PI NORWOOD PA 685 CANTON ST, NORWOOD, MA 02062 SN 0192-6225 J9 MICROWAVE J JI Microw. J. PD APR PY 1991 VL 34 IS 4 BP 26 EP & PG 0 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA FH125 UT WOS:A1991FH12500002 ER PT J AU BABBITT, R LENZING, E WILBER, W RACHLIN, A AF BABBITT, R LENZING, E WILBER, W RACHLIN, A TI FABRICATION AND EVALUATION OF SUPERCONDUCTING DEVICES SO MICROWAVE JOURNAL LA English DT Article RP BABBITT, R (reprint author), USA,ELECTR TECHNOL & DEVICES LAB,LABCOM,FT MONMOUTH,NJ 07703, USA. NR 10 TC 1 Z9 1 U1 0 U2 0 PU HORIZON HOUSE-MICROWAVE PI NORWOOD PA 685 CANTON ST, NORWOOD, MA 02062 SN 0192-6225 J9 MICROWAVE J JI Microw. J. PD APR PY 1991 VL 34 IS 4 BP 40 EP & PG 0 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA FH125 UT WOS:A1991FH12500004 ER PT J AU CARMICHAEL, L PERLMAN, B RHODES, D AF CARMICHAEL, L PERLMAN, B RHODES, D TI MHDL - BRIDGING THE DESIGN AND COMMUNICATION GAP SO MICROWAVE JOURNAL LA English DT Note AB A common, high level means to describe component and system behavior, define specifications and exchange data is needed to complement the microwave/mm-wave monolithic integrated circuits (MMIC) program. A new DARPA funded Phase 3 effort is underway to develop a MMIC hardware description language (MHDL) to satisfy this need. The development of MHDL is key to establishing microwave analog hardware specification and description capabilities that complement the digitally-oriented VHSIC hardware description language (VHDL). RP CARMICHAEL, L (reprint author), USA,LABCOM,ELECTR TECHNOL & DEVICES LAB,FT MONMOUTH,NJ 07703, USA. NR 1 TC 0 Z9 0 U1 0 U2 1 PU HORIZON HOUSE-MICROWAVE PI NORWOOD PA 685 CANTON ST, NORWOOD, MA 02062 SN 0192-6225 J9 MICROWAVE J JI Microw. J. PD APR PY 1991 VL 34 IS 4 BP 76 EP & PG 0 WC Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA FH125 UT WOS:A1991FH12500005 ER PT J AU KNAPIK, J STAAB, J BAHRKE, M REYNOLDS, K VOGEL, J OCONNOR, J AF KNAPIK, J STAAB, J BAHRKE, M REYNOLDS, K VOGEL, J OCONNOR, J TI SOLDIER PERFORMANCE AND MOOD STATES FOLLOWING A STRENUOUS ROAD MARCH SO MILITARY MEDICINE LA English DT Article AB Eighty-nine soldiers performed a maximal effort 20-km road march, carrying a total load of 46 kg. Compared to pre-march values, post-march marksmanship accuracy decreased 26% for number of target hits and 33% for distance from the centroid of the target. Maximal grenade throw distance decreased 9%, but there was no change in maximal vertical jump height. The Profile of Mood States questionnaire revealed an 82% increase in self-reported fatigue and 38% decrease in vigor. Significant decrements in some aspects of military performance occur when soldiers march rapidly with heavy loads over long distances. RP KNAPIK, J (reprint author), USA,TECHNOL RES INST,DIV EXERCISE PHYSIOL,NATICK,MA 01760, USA. NR 0 TC 23 Z9 23 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD APR PY 1991 VL 156 IS 4 BP 197 EP 200 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA FG528 UT WOS:A1991FG52800012 PM 2030843 ER PT J AU HALLIDAY, AW VUKELJA, SJ AF HALLIDAY, AW VUKELJA, SJ TI NEUROLOGIC MANIFESTATIONS OF VITAMIN-B-12 DEFICIENCY IN A MILITARY HOSPITAL SO MILITARY MEDICINE LA English DT Article AB Although it is well recognized that patients with cobalamin (vitamin B-12) deficiency can develop neuropsychiatric problems, primary care physicians do not frequently realize that patients presenting with only vague neurologic complaints can have vitamin B-12 deficiency as the etiology. During a 1-year period, six patients presented to the Neurology Clinic at Brooke Army Medical Center, Fort Sam Houston, Texas, after evaluation at the primary care level for their neurologic complaints. All six had cobalamin deficiency, and none were anemic. Military primary care physicians should be aware of the various neurologic presentations of these patients. RP HALLIDAY, AW (reprint author), BROOKE ARMY MED CTR,NEUROL SERV,FT SAM HOUSTON,TX 78234, USA. NR 0 TC 3 Z9 3 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD APR PY 1991 VL 156 IS 4 BP 201 EP 204 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA FG528 UT WOS:A1991FG52800013 PM 2030844 ER PT J AU MARSHALL, VM COPPEL, RL MARTIN, RK ODUOLA, AMJ ANDERS, RF KEMP, DJ AF MARSHALL, VM COPPEL, RL MARTIN, RK ODUOLA, AMJ ANDERS, RF KEMP, DJ TI A PLASMODIUM-FALCIPARUM MSA-2 GENE APPARENTLY GENERATED BY INTRAGENIC RECOMBINATION BETWEEN THE 2 ALLELIC FAMILIES SO MOLECULAR AND BIOCHEMICAL PARASITOLOGY LA English DT Note ID MEROZOITE SURFACE-ANTIGENS; POLYMERASE; PRECURSOR; PROTEINS; MALARIA; DNA C1 ROYAL MELBOURNE HOSP,WALTER & ELIZA HALL INST MED RES,PARKVILLE,VIC 3050,AUSTRALIA. UNIV IBADAN,IBADAN,NIGERIA. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. RI Coppel, Ross/A-6626-2008 OI Coppel, Ross/0000-0002-4476-9124 NR 10 TC 43 Z9 43 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-6851 J9 MOL BIOCHEM PARASIT JI Mol. Biochem. Parasitol. PD APR PY 1991 VL 45 IS 2 BP 349 EP 351 DI 10.1016/0166-6851(91)90104-E PG 3 WC Biochemistry & Molecular Biology; Parasitology SC Biochemistry & Molecular Biology; Parasitology GA FC458 UT WOS:A1991FC45800020 PM 2038365 ER PT J AU NORTHAM, RS SINGER, HS AF NORTHAM, RS SINGER, HS TI POSTENCEPHALITIC ACQUIRED TOURETTE-LIKE SYNDROME IN A CHILD SO NEUROLOGY LA English DT Note C1 WALTER REED ARMY MED CTR,DEPT CHILD NEUROL,WASHINGTON,DC 20307. JOHNS HOPKINS UNIV,SCH MED,DEPT NEUROL,BALTIMORE,MD 21205. JOHNS HOPKINS UNIV,SCH MED,DEPT PEDIAT,BALTIMORE,MD 21205. FU NICHD NIH HHS [HD 25806]; NINDS NIH HHS [NS 27327] NR 8 TC 25 Z9 26 U1 0 U2 0 PU LITTLE BROWN CO PI BOSTON PA 34 BEACON STREET, BOSTON, MA 02108-1493 SN 0028-3878 J9 NEUROLOGY JI Neurology PD APR PY 1991 VL 41 IS 4 BP 592 EP 593 PG 2 WC Clinical Neurology SC Neurosciences & Neurology GA FG377 UT WOS:A1991FG37700026 PM 1849241 ER PT J AU SHAVES, M BARNHILL, D BOSSCHER, J REMMENGA, S HAHN, M PARK, R AF SHAVES, M BARNHILL, D BOSSCHER, J REMMENGA, S HAHN, M PARK, R TI INDWELLING EPIDURAL CATHETERS FOR PAIN CONTROL IN GYNECOLOGIC CANCER-PATIENTS SO OBSTETRICS AND GYNECOLOGY LA English DT Article ID MORPHINE; MANAGEMENT AB Seven patients with severe pain caused by an advanced, incurable gynecologic malignancy were treated with an indwelling epidural catheter connected to an implantable subcutaneous port through which morphine was infused. There were few major complications associated with insertion or maintenance of the system. The average usage was 60 days, although the system functioned continuously for 6 months in one patient. Pain distribution in these women ranged from the upper abdomen to the lower extremities. All patients, including one with liver metastases, reported good to excellent pain control with the epidural narcotics. Two subjects with upper abdominal pain occasionally required supplemental oral oxycodone, but the other five patients had adequate pain relief with the epidural system alone. The indwelling epidural system provides excellent analgesia for patients with advanced, incurable gynecologic cancer. C1 WALTER REED ARMY MED CTR,DEPT ANESTHESIA & OPERAT SERV,PAIN MANAGEMENT SECT,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT OBSTET & GYNECOL,GYNECOL ONCOL SERV,WASHINGTON,DC 20307. NR 10 TC 7 Z9 7 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0029-7844 J9 OBSTET GYNECOL JI Obstet. Gynecol. PD APR PY 1991 VL 77 IS 4 BP 642 EP 644 PG 3 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA FD561 UT WOS:A1991FD56100032 PM 2002993 ER PT J AU VINCENT, JM WACK, RP PERSON, DA BASS, JW AF VINCENT, JM WACK, RP PERSON, DA BASS, JW TI PERTUSSIS AS THE CAUSE OF RECURRENT BRADYCARDIA IN A YOUNG INFANT SO PEDIATRIC INFECTIOUS DISEASE JOURNAL LA English DT Note DE PERTUSSIS; BRADYCARDIA ID DIAGNOSIS RP VINCENT, JM (reprint author), TRIPLER ARMY MED CTR,DEPT PEDIAT,HONOLULU,HI 96859, USA. NR 13 TC 9 Z9 10 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0891-3668 J9 PEDIATR INFECT DIS J JI Pediatr. Infect. Dis. J. PD APR PY 1991 VL 10 IS 4 BP 340 EP 342 DI 10.1097/00006454-199104000-00019 PG 3 WC Immunology; Infectious Diseases; Pediatrics SC Immunology; Infectious Diseases; Pediatrics GA FF988 UT WOS:A1991FF98800019 PM 2062635 ER PT J AU SHANLEY, DJ MULLIGAN, ME AF SHANLEY, DJ MULLIGAN, ME TI OSTEOSARCOMA WITH ISOLATED METASTASES TO THE PLEURA SO PEDIATRIC RADIOLOGY LA English DT Note AB Osteosarcoma is the most common primary skeletal malignancy of childhood, typically occurring between the ages of 10 and 20. The classic radiographic appearance is that of a mixeds lytic and sclerotic lesion originating in the metaphysis of the long bones with cortical destruction, periostitis, and an associated soft tissue mass. Metastatic disease to the lungs is an important prognostic indicator and is found in the majority of patients dying of the disease [1]. We present a child with osteosarcoma of the distal femur who developed extensive metastatic disease involvings the chest pleura bilaterally with no other sites of involvement. RP SHANLEY, DJ (reprint author), TRIPLER ARMY MED CTR,DEPT RADIOL,HONOLULU,HI 96859, USA. NR 2 TC 7 Z9 7 U1 0 U2 0 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0301-0449 J9 PEDIATR RADIOL JI Pediatr. Radiol. PD APR PY 1991 VL 21 IS 3 BP 226 EP 226 DI 10.1007/BF02011054 PG 1 WC Pediatrics; Radiology, Nuclear Medicine & Medical Imaging SC Pediatrics; Radiology, Nuclear Medicine & Medical Imaging GA FF522 UT WOS:A1991FF52200018 PM 2047165 ER PT J AU BALARAMAN, V WILSON, CM NAKAMURA, KT PERKINS, TA EASA, D MELISH, M AF BALARAMAN, V WILSON, CM NAKAMURA, KT PERKINS, TA EASA, D MELISH, M TI SEVERE NEONATAL HEPATITIS-A (HAV) INFECTION IN THE NEWBORN SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 UNIV HAWAII,KAPIOLANI MED CTR,TRIPLER ARMY MED CTR,DEPT PEDIAT,HONOLULU,HI. NR 0 TC 0 Z9 0 U1 0 U2 1 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1991 VL 29 IS 4 BP A279 EP A279 PN 2 PG 1 WC Pediatrics SC Pediatrics GA FE038 UT WOS:A1991FE03801655 ER PT J AU BEACHY, JC WEISMAN, LE AF BEACHY, JC WEISMAN, LE TI THE EFFECT OF ASPHYXIA ON GROUP-B STREPTOCOCCAL (GBS) INFECTION IN THE SUCKLING RAT SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 UNIFORMED SERV UNIV HLTH SCI,DEPT PEDIAT,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,DEPT PEDIAT,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1991 VL 29 IS 4 BP A280 EP A280 PN 2 PG 1 WC Pediatrics SC Pediatrics GA FE038 UT WOS:A1991FE03801658 ER PT J AU BECKER, JA ASCHER, DP WAECKER, NJ YODER, B WEISSE, M FAJARDO, JE FISCHER, GW AF BECKER, JA ASCHER, DP WAECKER, NJ YODER, B WEISSE, M FAJARDO, JE FISCHER, GW TI THE POOR SENSITIVITY OF URINE LATEX AGGLUTINATION TESTING IN NEONATES WITH GROUP-B STREPTOCOCCAL BACTEREMIA SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. NR 0 TC 1 Z9 1 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1991 VL 29 IS 4 BP A280 EP A280 PN 2 PG 1 WC Pediatrics SC Pediatrics GA FE038 UT WOS:A1991FE03801659 ER PT J AU BENT, RC WISWELL, TE AF BENT, RC WISWELL, TE TI COMPARISON OF MECHANICAL SUCTION TECHNIQUES FOR MECONIUM IN THE INVITRO PIGLET TRACHEA SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1991 VL 29 IS 4 BP A204 EP A204 PN 2 PG 1 WC Pediatrics SC Pediatrics GA FE038 UT WOS:A1991FE03801203 ER PT J AU FILDES, RD ATKINS, JL AF FILDES, RD ATKINS, JL TI SUBSTANCE P(SP) MEDIATES DECREASED FLUID REABSORPTION IN STRAIGHT PORTIONS OF RABBIT PROXIMAL TUBULE BY SP RECEPTOR INDEPENDENT MECHANISMS SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. GEORGETOWN UNIV,MED CTR,WASHINGTON,DC 20007. RI Atkins, James/B-3577-2011 NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1991 VL 29 IS 4 BP A342 EP A342 PN 2 PG 1 WC Pediatrics SC Pediatrics GA FE038 UT WOS:A1991FE03802034 ER PT J AU PICHOFF, BE UVEHARA, CFT NAKAMURA, KT AF PICHOFF, BE UVEHARA, CFT NAKAMURA, KT TI EFFECT OF THE CALCIUM AGONIST BAY K-8644 ON GUINEA-PIG AIRWAY SMOOTH-MUSCLE FUNCTION DURING DEVELOPMENT SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 UNIV HAWAII,TRIPLER ARMY MED CTR,RAPIOLANI MED CTR,DEPT PEDS,HONOLULU,HI 96822. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1991 VL 29 IS 4 BP A63 EP A63 PN 2 PG 1 WC Pediatrics SC Pediatrics GA FE038 UT WOS:A1991FE03800364 ER PT J AU STEVENS, EL SOUTHGATE, WM NAKAMURA, KT AF STEVENS, EL SOUTHGATE, WM NAKAMURA, KT TI LASIX RELAXES AIRWAY SMOOTH-MUSCLE IN FETAL AND ADULT GUINEA-PIGS SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 UNIV HAWAII,TRIPLER ARMY MED CTR,KAPIOLANI MED CTR,HONOLULU,HI 96822. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1991 VL 29 IS 4 BP A66 EP A66 PN 2 PG 1 WC Pediatrics SC Pediatrics GA FE038 UT WOS:A1991FE03800382 ER PT J AU UVEHARA, CFT PICHOFF, BE EASA, D NAKAMURA, KT AF UVEHARA, CFT PICHOFF, BE EASA, D NAKAMURA, KT TI HYPEROXIA INCREASES AIRWAY REACTIVITY IN NEWBORN GUINEA-PIGS SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 UNIV HAWAII,KAPIOLANI MED CTR,TRIPLER ARMY MED CTR,DEPT PEDIAT,HONOLULU,HI 96822. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1991 VL 29 IS 4 BP A378 EP A378 PN 2 PG 1 WC Pediatrics SC Pediatrics GA FE038 UT WOS:A1991FE03802250 ER PT J AU WEISSE, ME SEAL, LA PERSON, DA AF WEISSE, ME SEAL, LA PERSON, DA TI CHOLESTYRAMINE INCREASES RECOVERY OF VIRUS IN TISSUE-CULTURE SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 TRIPLER ARMY MED CTR,DEPT PEDIAT,HONOLULU,HI 96859. TRIPLER ARMY MED CTR,DEPT PATHOL,HONOLULU,HI 96859. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1991 VL 29 IS 4 BP A188 EP A188 PN 2 PG 1 WC Pediatrics SC Pediatrics GA FE038 UT WOS:A1991FE03801108 ER PT J AU WISWELL, TE HACHEY, WE AF WISWELL, TE HACHEY, WE TI EARLY MANAGEMENT OF THE MECONIUM ASPIRATION SYNDROME (MAS) WITH 3-METHODS OF HIGH-FREQUENCY VENTILATION OR CONVENTIONAL VENTILATION (CV) - A RANDOMIZED, PROSPECTIVE TRIAL SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1991 VL 29 IS 4 BP A335 EP A335 PN 2 PG 1 WC Pediatrics SC Pediatrics GA FE038 UT WOS:A1991FE03801992 ER PT J AU WISWELL, TE BLEY, JA AF WISWELL, TE BLEY, JA TI VENTILATION OF SURFACTANT-DEFICIENT RABBITS WITH A REVOLUTIONARY PNEUMATIC HIGH-FREQUENCY OSCILLATORY VENTILATOR COMPARED WITH CONVENTIONAL MECHANICAL VENTILATION SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1991 VL 29 IS 4 BP A335 EP A335 PN 2 PG 1 WC Pediatrics SC Pediatrics GA FE038 UT WOS:A1991FE03801991 ER PT J AU WISWELL, TE MCCREDY, R AF WISWELL, TE MCCREDY, R TI OUTCOME OF ASYMPTOMATIC TERM GESTATION NEONATES WHOSE MOTHERS RECEIVED INTRAPARTUM ANTIBIOTICS SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1991 VL 29 IS 4 BP A239 EP A239 PN 2 PG 1 WC Pediatrics SC Pediatrics GA FE038 UT WOS:A1991FE03801416 ER PT J AU WISWELL, TE HENLEY, MA AF WISWELL, TE HENLEY, MA TI INTRATRACHEAL SUCTIONING, SYSTEMIC INFECTION, AND THE MECONIUM ASPIRATION SYNDROME (MAS) SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1991 VL 29 IS 4 BP A239 EP A239 PN 2 PG 1 WC Pediatrics SC Pediatrics GA FE038 UT WOS:A1991FE03801415 ER PT J AU WISWELL, TE CURTIS, J DOBEK, AS ZIERDT, CH AF WISWELL, TE CURTIS, J DOBEK, AS ZIERDT, CH TI STAPHYLOCOCCAL-AUREUS COLONIZATION FOLLOWING NEONATAL CIRCUMCISION - IS THERE DEVICE DEPENDENCY SO PEDIATRIC RESEARCH LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NIH,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD APR PY 1991 VL 29 IS 4 BP A126 EP A126 PN 2 PG 1 WC Pediatrics SC Pediatrics GA FE038 UT WOS:A1991FE03800734 ER PT J AU SKOOG, SJ BELMAN, AB AF SKOOG, SJ BELMAN, AB TI PRIMARY VESICOURETERAL REFLUX IN THE BLACK-CHILD SO PEDIATRICS LA English DT Article DE VUR, VESICOURETERAL REFLUX; UTI, URINARY TRACT INFECTION ID URINARY-TRACT; MANAGEMENT AB Primary vesicoureteral reflux is a polygenic abnormality due to a deficiency of the ureterovesical junction which allows urine in the bladder to ascend into the ureter and kidney. Fifty-one black children with primary vesicoureteral reflux were evaluated and treated at Children's Hospital from 1976 to 1986. The results of the evaluation and treatment were compared with those of 493 white patients with primary vesicoureteral reflux seen during the same time interval. The general approach to management was nonsurgical. There were no radical differences in the mode of presentation, age at presentation and age at resolution. The distribution of reflux by maximum grade was not affected by race. Overall, 19 (37%) black children experienced spontaneous resolution of reflux. The mean duration of reflux in black children who had spontaneous resolution was 14.6 months. This duration was statistically significantly shorter than that in white patients with spontaneous resolution of vesicoureteral reflux (P < .005). Surgical correction was believed to be required in 8 (16%) patients and 8 (16%) were lost to follow-up. Renal scarring demonstrated by intravenous pyelogram or renal scan was initially present in 12 (23%) black patients compared with 65 (13%) white patients. This was due to a higher percentage of renal scarring in black girls which was not explained by distribution of grades of reflux. There was no progression of scarring in our black patients, whereas 3 (0.6%) white patients had progression of scarring. Although vesicoureteral reflux is rarely seen in black patients (9% of series), it has similar demographic features. Renal scarring is more frequent in black girls, but one can anticipate a faster rate of spontaneous resolution than in the white population. C1 CHILDRENS HOSP,NATL MED CTR,DEPT PEDIAT UROL,111 MICHIGAN AVE NW,WASHINGTON,DC 20010. WALTER REED ARMY MED CTR,PEDIAT UROL SECT,WASHINGTON,DC 20307. NR 18 TC 16 Z9 17 U1 0 U2 0 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD, ELK GROVE VILLAGE, IL 60007-1098 SN 0031-4005 J9 PEDIATRICS JI Pediatrics PD APR PY 1991 VL 87 IS 4 BP 538 EP 543 PG 6 WC Pediatrics SC Pediatrics GA FF727 UT WOS:A1991FF72700017 PM 2011432 ER PT J AU KIRBY, WC AF KIRBY, WC TI TURNER SYNDROME AND PARTIAL ANOMALOUS PULMONARY VENOUS DRAINAGE - REPLY SO PEDIATRICS LA English DT Letter RP KIRBY, WC (reprint author), WALTER REED ARMY MED CTR,WASHINGTON,DC 20307, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD, ELK GROVE VILLAGE, IL 60007-1098 SN 0031-4005 J9 PEDIATRICS JI Pediatrics PD APR PY 1991 VL 87 IS 4 BP 584 EP 585 PG 2 WC Pediatrics SC Pediatrics GA FF727 UT WOS:A1991FF72700035 ER PT J AU STEVENS, SB MORRISON, CA ALLIK, TH RHEINGOLD, AL HAGGERTY, BS AF STEVENS, SB MORRISON, CA ALLIK, TH RHEINGOLD, AL HAGGERTY, BS TI NALA(MOO4)2 AS A LASER HOST MATERIAL SO PHYSICAL REVIEW B LA English DT Article ID CRYSTAL-FIELD ANALYSIS; RARE-EARTH IONS; LANTHANUM TRIFLUORIDE; ND-YAG AB Crystallographic and optical properties of NaLa(MoO4)2 are presented. The positions of the Stark levels are reported for the [LS]J manifolds of Nd3+ and Er3+ up to the absorption edge in this host material. A least-squares fit to the data was performed to obtain the crystal-field parameters. For Nd3+ the following crystal-field parameters were obtained: B20 = 519, B40 = -695, B44 = 964, B60 = -190, and B64 = 673 + i384 cm-1, with a root-mean-square (rms) deviation of 7.7 cm-1. For Er3+ we obtained B20 = 422, B40 = -507, B44 = 839, B60 = -116, and B64 = 409 + i158 cm-1, with a rms deviation of 4.8 cm-1. Intensity calculations based on fits to the experimental data yield line-to-line and multiplet branching ratios. The results of this investigation indicate that Er3+:NaLa(MoO4)2 and Nd3+:NaLa(MoO4)2 show promise as diode-pumped laser materials. C1 SCI APPLICAT INT CORP,MCLEAN,VA 22102. UNIV DELAWARE,DEPT CHEM,NEWARK,DE 19716. RP STEVENS, SB (reprint author), USA,HARRY DIAMOND LABS,LAB COMMAND,ADELPHI,MD 20783, USA. NR 33 TC 71 Z9 74 U1 0 U2 2 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0163-1829 J9 PHYS REV B JI Phys. Rev. B PD APR 1 PY 1991 VL 43 IS 10 BP 7386 EP 7394 DI 10.1103/PhysRevB.43.7386 PN A PG 9 WC Physics, Condensed Matter SC Physics GA FE549 UT WOS:A1991FE54900002 ER PT J AU OWENS, FJ AF OWENS, FJ TI MICROWAVE-ABSORPTION BY VORTEX CORES IN THE HIGH-TEMPERATURE SUPERCONDUCTOR YBA2CU3O7-X SO PHYSICAL REVIEW B LA English DT Note ID HIGH-TC SUPERCONDUCTORS; OXIDES AB Direct absorption measurements of microwave energy having energy less than the superconducting gap in the granular composites of the 90-K superconductor YBa2Cu3O1-x as a function of dc magnetic-field strength between 0.1 and 1.0 T reveal a nonlinearly increasing absorption of microwave energy with increasing field strength. The absorption can be detected in regions of the T-H phase diagram in which thermally activated flux flow does not occur. The temperature and field dependences of the absorption are different from those for low-magnetic-field absorption (H < 0.06 T) and are shown to be consistent with the behavior expected by the absorption of microwave energy by normal carriers at the cores of vortices in type-II superconducting materials. C1 USA, CTR ARMAMENT RES & DEV, PICATINNY, NJ 07806 USA. RP OWENS, FJ (reprint author), CUNY HUNTER COLL, DEPT PHYS, 695 PK AVE, NEW YORK, NY 10021 USA. NR 16 TC 8 Z9 8 U1 0 U2 0 PU AMER PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1098-0121 EI 1550-235X J9 PHYS REV B JI Phys. Rev. B PD APR 1 PY 1991 VL 43 IS 10 BP 8631 EP 8633 DI 10.1103/PhysRevB.43.8631 PN B PG 3 WC Physics, Condensed Matter SC Physics GA FE551 UT WOS:A1991FE55100068 ER PT J AU BAUER, DM FINCH, DC MCGOUGH, KP BENSON, CJ FINSTUEN, K ALLISON, SC AF BAUER, DM FINCH, DC MCGOUGH, KP BENSON, CJ FINSTUEN, K ALLISON, SC TI A COMPARATIVE-ANALYSIS OF SEVERAL CRUTCH-LENGTH ESTIMATION TECHNIQUES SO PHYSICAL THERAPY LA English DT Article DE CRUTCHES; GAIT; ORTHOPEDIC EQUIPMENT AB The purpose of this study was to determine which of several crutch-fitting techniques best predicts ideal crutch length. One hundred seven active-duty military volunteers were measured for crutches using each of the following methods: (1) axillary fold to heel in the supine position, (2) olecranon to opposite third fingertip, (3) olecranon to opposite fifth fingertip, (4) 77% of height, (5) height minus 16 in (40.6 cm), (6) 77% of arm span, and (7) arm span minus 16 in (40.6 cm). The subject's self-reported heights and their actual measured heights were both used in calculations involving height. Ideal crutch length was determined by an experienced orthopedic physical therapist, with placement of the axillary pad 2.5 in (6.4 cm) below the axillary fold. Mean squared error indices were then computed as the average of the squared deviations of the technique measurements from the ideal crutch length. Of the techniques studied, the two involving minor arithmetical adjustments to the subjects' self-reported height were found to be good predictors: 77% of height and height minus 16 in (40.6 cm). The poorest predictor was axilla to heel in the supine position. Finally, two additional length estimates were derived using linear regression analyses. These estimates provided the best overall predictions based on actual height and reported height. A quick-reference table for crutch-length estimates based on patient heights was developed from these regression results. C1 BAYLOR UNIV,USA,ACAD HLTH SCI,DIV MED & SURG,PHYS THERAPY BRANCH,GRAD PROGRAM PHYS THERAPY,FT SAM HOUSTON,TX 78234. MCDONALD ARMY COMMUNITY HOSP,FT EUSTIS,VA 23604. WINN ARMY COMMUNITY HOSP,FT STEWART,GA 31314. US MIL ACAD,KELLER ARMY HOSP,W POINT,NY 10996. NR 18 TC 9 Z9 9 U1 0 U2 0 PU AMER PHYS THER ASSN PI ALEXANDRIA PA 1111 N FAIRFAX ST, ALEXANDRIA, VA 22314 SN 0031-9023 J9 PHYS THER JI Phys. Ther. PD APR PY 1991 VL 71 IS 4 BP 294 EP 300 PG 7 WC Orthopedics; Rehabilitation SC Orthopedics; Rehabilitation GA FF142 UT WOS:A1991FF14200007 PM 2008452 ER PT J AU SEIZINGER, BR SMITH, DI FILLINGKATZ, MR NEUMANN, H GREEN, JS CHOYKE, PL ANDERSON, KM FREIMAN, RN KLAUCK, SM WHALEY, J DECKER, HJH HSIA, YE COLLINS, D HALPERIN, J LAMIELL, JM OOSTRA, B WAZIRI, MH GORIN, MB SCHERER, G DRABKIN, HA ARONIN, N SCHINZEL, A MARTUZA, RL GUSELLA, JF HAINES, JL AF SEIZINGER, BR SMITH, DI FILLINGKATZ, MR NEUMANN, H GREEN, JS CHOYKE, PL ANDERSON, KM FREIMAN, RN KLAUCK, SM WHALEY, J DECKER, HJH HSIA, YE COLLINS, D HALPERIN, J LAMIELL, JM OOSTRA, B WAZIRI, MH GORIN, MB SCHERER, G DRABKIN, HA ARONIN, N SCHINZEL, A MARTUZA, RL GUSELLA, JF HAINES, JL TI GENETIC FLANKING MARKERS REFINE DIAGNOSTIC-CRITERIA AND PROVIDE INSIGHTS INTO THE GENETICS OF VONHIPPEL LINDAU DISEASE SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE HEREDITARY TUMOR SYNDROME; RENAL CELL CARCINOMA; PHEOCHROMOCYTOMA; BRAIN TUMORS; TUMOR SUPPRESSOR GENE ID RENAL-CELL CARCINOMA; TRANSLOCATION; LOCALIZATION; NEUROFIBROMATOSIS; CHROMOSOME-3; LINKAGE AB Von Hippel Lindau disease (VHL) is a hereditary syndrome, associated with tumors and cysts in multiple organ systems, whose expression and age of onset are highly variable. The availability of a genetic test for the early and reliable detection of individuals carrying the defective gene would be beneficial for VHL patients and their relatives, since many of the manifestations of VHL can be successfully treated if detected in their early stages, while the complications of undetected disease can be devastating. We have previously shown that the VHL gene maps to chromosome 3p. To provide genetic markers for the development of a reliable diagnostic test, and to further narrow and eventually clone the VHL defect, we have generated DNA markers for chromosome 3p. With these markers, we have performed a multipoint genetic linkage analysis in 28 VHL pedigrees, comprising 470 individuals, 164 of whom were affected with VHL. Here we report the identification of tightly linked markers, including flanking markers that bracket the VHL gene to a small region on chromosome 3p25-p26. This finding has several major implications. While visceral cysts of the kidney, pancreas, and epididymis are commonly found in VHL and are considered diagnostic criteria for this disorder, they also occur in the general population. The presence of cysts, unaccompanied by other more typical lesions such as retinal and cerebellar hemangioblastoma, may therefore represent a major diagnostic problem, leading to errors in the assessment of disease status. The application of flanking markers for the VHL gene for presymptomatic diagnostic testing confirms that epididymal cysts are indeed not suitable as a diagnostic criterion in this disorder. Pheochromocytomas occur nonuniformly in VHL families and may also be associated with other hereditary tumor syndromes; our genetic studies imply that the phenotype in VHL families with and without pheochromocytomas is caused by defects within the same gene. The absence or presence of this tumor type is therefore due to the pleiotropic expression of a single gene rather than to the existence of several different genes for VHL. The region on chromosome 3p13-p14 known to contain several chromosomal translocation breakpoints in families with "pure familial renal cell carcinoma" is quite proximal to the VHL locus in 3p25-p26 we have identified. Chromosome 3p may therefore contain two loci for renal cell carcinoma: one gene (or genes) in 3p13-p14 and the VHL gene in 3p25-p26, whose aberration is also associated with other typical manifestations of VHL. Since renal cell carcinoma, pheochromocytoma, and visceral cysts can occur sporadically even in young people and may also be associated with other tumor syndromes, the availability of flanking markers for the VHL gene will be useful in identifying VHL gene carriers, particularly among those individuals at risk in whom these are the only manifestations of disease. The isolation and characterization of the VHL gene, based on the identification of flanking markers, will have important implications for diagnosis and treatment of patients with VHL, as well as for a much larger number of individuals having the sporadic counterparts of VHL-associated tumor types. C1 MASSACHUSETTS GEN HOSP,NEUROSURG SERV,BOSTON,MA 02114. MASSACHUSETTS GEN HOSP,MOLEC NEUROGENET LAB,BOSTON,MA 02114. HARVARD UNIV,SCH MED,BOSTON,MA 02115. WAYNE STATE UNIV,DEPT MOLEC BIOL & GENET,DETROIT,MI 48202. UNIV LOUISVILLE,DEPT NEUROL,LOUISVILLE,KY 40202. UNIV FREIBURG,DEPT MED,W-7800 FREIBURG,GERMANY. UNIV FREIBURG,INST GENET,W-7800 FREIBURG,GERMANY. MEM UNIV NEWFOUNDLAND,DEPT COMMUNITY MED,ST JOHNS A1B 3V6,NEWFOUNDLAND,CANADA. UNIV PITTSBURGH,INST EYE & EAR,DEPT OPHTHALMOL,PITTSBURGH,PA 15213. UNIV KANSAS,MED CTR,DEPT MED,KANSAS CITY,KS 66103. UNIV HAWAII,DEPT GENET,HONOLULU,HI 96826. UNIV HAWAII,DEPT PEDIAT,HONOLULU,HI 96826. MT SINAI MED CTR,DEPT NEUROL,NEW YORK,NY 10029. BROOKE ARMY MED CTR,CRIT CARE SERV,FT SAM HOUSTON,TX 78234. ERASMUS UNIV,DEPT CLIN GENET,3000 DR ROTTERDAM,NETHERLANDS. UNIV IOWA HOSP & CLIN,DEPT PEDIAT,IOWA CITY,IA 52242. UNIV COLORADO,DEPT MED,DENVER,CO 80262. UNIV ZURICH,DEPT HUMAN GENET,CH-8006 ZURICH,SWITZERLAND. UNIV MASSACHUSETTS,DEPT MED,WORCESTER,MA 01655. RP SEIZINGER, BR (reprint author), MASSACHUSETTS GEN HOSP,MOLEC NEUROONCOL LAB,BOSTON,MA 02114, USA. RI Haines, Jonathan/C-3374-2012 FU NCI NIH HHS [R0I-CA49455]; NINDS NIH HHS [R0I NS22224] NR 33 TC 118 Z9 119 U1 0 U2 1 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD APR PY 1991 VL 88 IS 7 BP 2864 EP 2868 DI 10.1073/pnas.88.7.2864 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA FE864 UT WOS:A1991FE86400053 PM 2011596 ER PT J AU WESTERVELT, P GENDELMAN, HE RATNER, L AF WESTERVELT, P GENDELMAN, HE RATNER, L TI IDENTIFICATION OF A DETERMINANT WITHIN THE HUMAN IMMUNODEFICIENCY VIRUS-1 SURFACE ENVELOPE GLYCOPROTEIN CRITICAL FOR PRODUCTIVE INFECTION OF PRIMARY MONOCYTES SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE MACROPHAGE; TROPISM; 3RD VARIABLE DOMAIN OF GP120; CD4 ID HTLV-III; MOLECULAR CLONE; AIDS VIRUS; T-CELL; RECEPTOR; RETROVIRUS; TYPE-1; GENE; CD4; PATHOGENESIS AB Profound differences exist in the replicative capacities of various human immunodeficiency virus 1 isolates in primary human monocytes. To investigate the molecular basis for these differences, recombinant full-length clones were constructed by reciprocal DNA fragment exchange between a molecular clone derived from a monocyte-tropic isolate (ADA) and portions of two full-length clones incapable of infection or replication in primary monocyte cultures (HXB2 and NL4-3). Virions derived from proviral clones that contained ADA sequences encoding vpu and the N and C termini of the surface envelope glycoprotein (gp120) were incapable of replication in monocytes. However, a 283-base-pair ADA sequence encoding amino acids 240-333 of the mature gp120 protein conferred the capacity for high-level virus replication in primary monocytes. The predicted amino acid sequence of this ADA clone differed from NL4-3 and HXB2 at 22 of 94 residues in this portion of gp120, which includes the entire third variable domain. Only 2 of 11 residues implicated in CD4 binding are located in this region of gp120 and are identical in HXB2, NL4-3, and ADA. Alignment of the ADA sequence with published amino acid sequences of three additional monocyte-replicative and three monocyte-nonreplicative clones indicates 6 discrete residues with potential involvement in conferring productive human immunodeficiency virus 1 infection of primary monocytes. C1 WASHINGTON UNIV,SCH MED,DEPT MED,660 S EUCLID AVE,ST LOUIS,MO 63110. WASHINGTON UNIV,SCH MED,DEPT MOLEC MICROBIOL,ST LOUIS,MO 63110. WALTER REED ARMY MED CTR,DEPT CELLULAR IMMUNOL,HIV IMMUNOPATHOGENESIS PROGRAM,WASHINGTON,DC 20307. HENRY M JACKSON FDN ADV MIL MED,ROCKVILLE,MD 20850. FU NIAID NIH HHS [5T32AI07172, AI 24745] NR 44 TC 273 Z9 273 U1 0 U2 2 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD APR PY 1991 VL 88 IS 8 BP 3097 EP 3101 DI 10.1073/pnas.88.8.3097 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA FG913 UT WOS:A1991FG91300028 PM 2014229 ER PT J AU OCKENHOUSE, CF KLOTZ, FW TANDON, NN JAMIESON, GA AF OCKENHOUSE, CF KLOTZ, FW TANDON, NN JAMIESON, GA TI SEQUESTRIN, A CD36 RECOGNITION PROTEIN ON PLASMODIUM-FALCIPARUM MALARIA-INFECTED ERYTHROCYTES IDENTIFIED BY ANTIIDIOTYPE ANTIBODIES SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE ERYTHROCYTE MEMBRANE; SEQUESTRATION; MOLECULAR MIMICRY; CYTOADHERENCE ID MEMBRANE GLYCOPROTEIN; MONOCLONAL-ANTIBODY; CYTOADHERENCE; RECEPTOR; EXPRESSION; SURFACE; MONOCYTES; INVITRO AB The CD36 molecule expressed by human endothelial cells is a receptor for the adhesion of erythrocytes infected with the human malaria parasite Plasmodium falciparum. A CD36-specific monoclonal antibody, OKM8, inhibits the adhesion of malaria-infected erythrocytes (IRBC) to purified CD36 and cells expressing CD36. Monospecific polyclonal anti-idiotype (anti-Id) antibodies, raised against monoclonal antibody OKM8, expressed determinants molecularly mimicking the CD36 binding domain for the adhesion of IRBC. Purified rabbit anti-Id antibodies reacted with the surface of IRBC by immunofluorescence, directly supported the adhesion of wild-type P. falciparum malaria isolates, and inhibited IRBC cytoadherence to melanoma cells. An almost-equal-to 270-kDa protein was immunoprecipitated by the anti-Id antibodies from surface-labeled and metabolically labeled IRBC and was competitively inhibited by soluble CD36. These results support the hypothesis that CD36 is a receptor and the almost-equal-to 270-kDa protein, sequestrin, is a complementary ligand involved in the adhesion of IRBC to host-cell endothelium. Sequestrin is a candidate malaria vaccine antigen, and anti-Id antibodies that recognize this molecule may be useful for passive immunotherapy of cerebral and severe P. falciparum malaria. C1 AMER RED CROSS,CELL BIOL LAB,ROCKVILLE,MD 20855. WALTER REED ARMY MED CTR,IMMUNOL BRANCH,WASHINGTON,DC 20307. RP OCKENHOUSE, CF (reprint author), WALTER REED ARMY MED CTR,DEPT MED,WASHINGTON,DC 20307, USA. FU NHLBI NIH HHS [HL40858] NR 16 TC 98 Z9 99 U1 1 U2 1 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD APR PY 1991 VL 88 IS 8 BP 3175 EP 3179 DI 10.1073/pnas.88.8.3175 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA FG913 UT WOS:A1991FG91300044 PM 1707534 ER PT J AU MALIK, A EGAN, JE HOUGHTEN, RA SADOFF, JC HOFFMAN, SL AF MALIK, A EGAN, JE HOUGHTEN, RA SADOFF, JC HOFFMAN, SL TI HUMAN CYTOTOXIC LYMPHOCYTES-T AGAINST THE PLASMODIUM-FALCIPARUM CIRCUMSPOROZOITE PROTEIN SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE MALARIA; SPOROZOITE; TRANSFECTION; PROTECTIVE IMMUNITY; VACCINE ID MALARIA SPOROZOITES; CELLS; EPITOPE; VIRUS; SPECIFICITY; PARASITE; ANTIGEN; GENE AB Cytotoxic T lymphocytes (CTL) against the circumsporozoite (CS) protein of malaria sporozoites protect against malaria in rodents. Although there is interest in developing human vaccines that induce CTL against the Plasmodium falciparum CS protein, humans have never been shown to produce CTL against any Plasmodium species protein or other parasite protein. We report that when peripheral blood mononuclear cells (PBMC) from three of four volunteers immunized with irradiated P. falciparum sporozoites were stimulated in vitro with a recombinant vaccinia virus expressing the P. falciparum CS protein or a peptide including only amino acids 368-390 of the P. falciparum CS protein [CS-(368-390)], the PBMC lysed autologous Epstein-Barr virus-transformed B cells transfected with the P. falciparum CS protein gene or incubated with CS-(368-390) tricosapeptide. Activity was antigen specific, genetically restricted, and dependent on CD8+ T cells. In one volunteer, seven peptides reflecting amino acids 311-400 were tested, and, as in B10.BR mice, CTL activity was only associated with the CS-(368-390) peptide. Development of an assay for studying human CTL against the CS and other malaria proteins and a method for constructing target cells by direct gene transfection provide a foundation for studying the role of CTL in protection against malaria. C1 USN,MED RES INST,MALARIA PROGRAM,BETHESDA,MD 20889. TORREY PINES INST MOLEC STUDIES,SAN DIEGO,CA 92121. WALTER REED ARMY MED CTR,DIV COMMUNICABLE DIS & IMMUNOL,WASHINGTON,DC 20307. NR 27 TC 147 Z9 147 U1 1 U2 3 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD APR PY 1991 VL 88 IS 8 BP 3300 EP 3304 DI 10.1073/pnas.88.8.3300 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA FG913 UT WOS:A1991FG91300070 PM 1707538 ER PT J AU REUSS, M AF REUSS, M TI THE CONTROL OF NATURE - MCPHEE,J SO TECHNOLOGY AND CULTURE LA English DT Book Review RP REUSS, M (reprint author), USA,CORPS ENGINEERS,WASHINGTON,DC 20310, USA. NR 1 TC 0 Z9 0 U1 0 U2 1 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0040-165X J9 TECHNOL CULT JI Technol. Cult. PD APR PY 1991 VL 32 IS 2 BP 405 EP 407 DI 10.2307/3105724 PG 3 WC History & Philosophy Of Science SC History & Philosophy of Science GA FQ874 UT WOS:A1991FQ87400015 ER PT J AU CHANH, TC SIWAK, EB HEWETSON, JF AF CHANH, TC SIWAK, EB HEWETSON, JF TI ANTI-IDIOTYPE-BASED VACCINES AGAINST BIOLOGICAL TOXINS SO TOXICOLOGY AND APPLIED PHARMACOLOGY LA English DT Article ID B SURFACE-ANTIGEN; T-2 TOXIN; MONOCLONAL-ANTIBODIES; IMMUNE-RESPONSE; INTERNAL IMAGE; MICE; VIRUS; IMMUNIZATION; ENHANCEMENT; PROTECTION C1 USA,MED RES INST INFECT DIS,FREDERICK,MD 21701. RP CHANH, TC (reprint author), SW FDN BIOMED RES,DEPT VIROL & IMMUNOL,SAN ANTONIO,TX 78284, USA. NR 33 TC 14 Z9 14 U1 0 U2 2 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0041-008X J9 TOXICOL APPL PHARM JI Toxicol. Appl. Pharmacol. PD APR PY 1991 VL 108 IS 2 BP 183 EP 193 DI 10.1016/0041-008X(91)90109-R PG 11 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA FG044 UT WOS:A1991FG04400001 PM 2017749 ER PT J AU SMALLRIDGE, RC CARR, FE FEIN, HG AF SMALLRIDGE, RC CARR, FE FEIN, HG TI DIISOPROPYLFLUOROPHOSPHATE (DFP) REDUCES SERUM PROLACTIN, THYROTROPIN, LUTEINIZING-HORMONE, AND GROWTH-HORMONE AND INCREASES ADRENOCORTICOTROPIN AND CORTICOSTERONE IN RATS - INVOLVEMENT OF DOPAMINERGIC AND SOMATOSTATINERGIC AS WELL AS CHOLINERGIC PATHWAYS SO TOXICOLOGY AND APPLIED PHARMACOLOGY LA English DT Article ID CORTICOTROPIN-RELEASING HORMONE; HYPOPHYSEAL PORTAL BLOOD; CYCLIC-AMP ACCUMULATION; PITUITARY TUMOR-CELLS; ESTROGEN-TREATED RATS; THYROID-HORMONE; NOREPINEPHRINE STIMULATE; PLASMA PROLACTIN; AFTERNOON SURGE; FEMALE RATS C1 WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307. RP SMALLRIDGE, RC (reprint author), WALTER REED ARMY MED CTR,DEPT CLIN PHYSIOL,DIV MED,WASHINGTON,DC 20307, USA. NR 53 TC 37 Z9 37 U1 0 U2 0 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0041-008X J9 TOXICOL APPL PHARM JI Toxicol. Appl. Pharmacol. PD APR PY 1991 VL 108 IS 2 BP 284 EP 295 DI 10.1016/0041-008X(91)90118-X PG 12 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA FG044 UT WOS:A1991FG04400010 PM 1673267 ER PT J AU PIERCE, DE BURNS, RP DAUPLAISE, HM MIZERKA, LJ AF PIERCE, DE BURNS, RP DAUPLAISE, HM MIZERKA, LJ TI THERMAL-DESORPTION SPECTROSCOPY OF SPUTTERED MOSX FILMS SO TRIBOLOGY TRANSACTIONS LA English DT Article; Proceedings Paper CT 45TH ANNUAL MEETING OF THE SOC TRIBOLOGISTS AND LUBRICATION ENGINEERS CY MAY 07-10, 1990 CL DENVER, CO SP SOC TRIBOLOGISTS & LUBRICAT ENGINEERS ID MOLYBDENUM-DISULFIDE SURFACES; SINGLE-CRYSTAL SURFACES; ADSORPTION AB Thermal desorption spectroscopy (TDS) is introduced as a diagnostic tool for determining the thermal stability of solid lubricant films. In particular, TDS revealed the temperatures at which various decomposition processes occurred as sputtered films were heated in vacuum. The primary film decomposition products detected were SO2 beginning at about 425K, and S2 beginning at about 1150K. A close relationship between water desorption beginning about 400K and SO2 desorption exists in the temperature range 400k-800-K. Besides chemical decomposition products, a significant amount of argon trapped in the film during the sputtering process is released at various temperatures. TDS results for sputtered films were compared with results for burnished films and with thermo-gravimetric (TGA) analysis, water adsorption, and other relevant studies of molybdenum disulfide found in the literature. TDS also showed that N+ ion-beam modification of sputtered films resulted in a decrease in desorption of SO2. Along with TDS, X-ray photoelectron spectroscopy (XPS) was used to study the effect of heating on the solid lubricant films. In addition, scanning electron microscopy (SEM), wavelength dispersive spectroscopy (WDS), and Rutherford backscattering spectroscopy (RBS) were used to characterize the samples. C1 RADC,ESOC,BEDFORD,MA. USA,MAT TECHNOL LAB,WATERTOWN,MA 02172. RP PIERCE, DE (reprint author), UNIV ILLINOIS,CHICAGO,IL 60680, USA. NR 43 TC 7 Z9 7 U1 0 U2 2 PU SOC TRIBOLOGISTS & LUBRICATION ENGINEERS PI PARK RIDGE PA 838 BUSSE HIGHWAY, PARK RIDGE, IL 60068 SN 0569-8197 J9 TRIBOL T JI Tribol. Trans. PD APR PY 1991 VL 34 IS 2 BP 205 EP 214 DI 10.1080/10402009108982028 PG 10 WC Engineering, Mechanical SC Engineering GA FG321 UT WOS:A1991FG32100007 ER PT J AU MCGEE, T KRAUS, N COMPERATORE, C NICOL, T AF MCGEE, T KRAUS, N COMPERATORE, C NICOL, T TI SUBCORTICAL AND CORTICAL COMPONENTS OF THE MLR GENERATING-SYSTEM SO BRAIN RESEARCH LA English DT Article DE AUDITORY EVOKED POTENTIAL; MIDDLE LATENCY RESPONSE; GENERATOR; GUINEA PIG; MEDIAL GENICULATE BODY; AUDITORY CORTEX; RETICULAR FORMATION; INFERIOR COLLICULUS ID AUDITORY EVOKED-POTENTIALS; MIDDLE-LATENCY RESPONSES; BRAIN-STEM; GUINEA-PIG; CAT; LESIONS; SLEEP; DEAFNESS; PATIENT; AGNOSIA AB The contributions of the auditory thalamo-cortical pathway, mesencephalic reticular formation, and inferior colliculus to the surface recorded auditory middle latency response (MLR) were assessed by selective inactivation of these areas with lidocaine. Evoked responses were recorded simultaneously from these areas and from the cortical surface. Lidocaine-induced changes were compared across recording sites. In the guinea pig, surface components measured from over the temporal lobe (waves A, B and C) and the midline (waves M- and M+) have been previously shown to reflect the activity of two distinct generating mechanisms. Effects of lidocaine injections corresponded to selective changes in components from these two systems. Injections in the medial geniculate body (MGB) were associated with total disruption of surface potentials measured over the temporal lobe, auditory cortex (AC) responses, and local activity in MGB. Thus the thalamo-cortical pathway appears to be important for the generation of MLRs recorded from the surface of the temporal lobe. These injections generally did not alter the surface midline responses or activity obtained from either the mesencephalic reticular formation (mRF) or the inferior colliculus (IC). Lidocaine injections within AC did not alter the basic response morphology of surface potentials, nor were significant changes measured within AC. Lidocaine injections into the mRF produced changes in all surface temporal potentials, the M+ midline surface potential, and in local potentials recorded from MGB and mRF. Injections into the IC changed surface and subcortical responses at all sites. This was the only injection to affect activity at the latency of surface midline wave, M-. This wave may be the animal analogue for human wave Na. Control experiments indicated that the effects observed were specific to the neural inactivation of target areas. The MLR generating system appears to consist of contributions and interactions from multiple areas including the auditory thalamo-cortical pathway, mRF and IC. The animal model and experimental strategy described appear promising for linking the contributions from specific brain areas to surface MLR waves. C1 USA,AEROMED RES LAB,FT RUCKER,AL 36360. RP MCGEE, T (reprint author), NORTHWESTERN UNIV,FRANCES SEARLE BLDG,2299 SHERIDAN RD,EVANSTON,IL 60208, USA. FU NIDCD NIH HHS [DC00264] NR 61 TC 62 Z9 62 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0006-8993 J9 BRAIN RES JI Brain Res. PD MAR 29 PY 1991 VL 544 IS 2 BP 211 EP 220 DI 10.1016/0006-8993(91)90056-2 PG 10 WC Neurosciences SC Neurosciences & Neurology GA FG196 UT WOS:A1991FG19600005 PM 2039939 ER PT J AU CRAMER, CJ AF CRAMER, CJ TI THE FLUOROPHOSPHORANYL SERIES - THEORETICAL INSIGHTS INTO RELATIVE STABILITIES AND LOCALIZATION OF SPIN SO JOURNAL OF THE AMERICAN CHEMICAL SOCIETY LA English DT Article ID MOLECULAR-ORBITAL METHODS; ABINITIO CONFIGURATION-INTERACTION; ELECTRON CORRELATION-ENERGY; PHOSPHORANYL RADICALS; ORGANOPHOSPHONATE BIODEGRADATION; PERTURBATION-THEORY; RESONANCE-SPECTRA; WAVE-FUNCTIONS; BASIS SET; CONSTANTS AB The nine isomeric local minima within the complete fluorophosphoranyl series (H(n)PF4-n., n = 0-4) have been investigated at the UHF/6-31G* and higher levels. Quantitative analysis of fluorine apicophilicity and hyperconjugative effects within the trigonal-bipyramidal series is presented. The ability of atomic orbitals on axially disposed fluorine atoms to participate in either a hyperconjugative donor or acceptor role is quite limited in comparison to analogous opportunities for equatorially disposed fluorine atoms. Decomposition of metathesis energy changes into apicophilic and hyperconjugative components permits rational evaluation of the corresponding equilibria. Localization of spin density is accomplished efficiently by using the calculated MP2/6-311G** electron density. Fermi contact integrals derived therefrom allow for highly accurate prediction of isotropic hyperfine coupling constants after application of a small scaling factor. Techniques alternatively using s-orbital spin density for such predictions are far less satisfactory. RP CRAMER, CJ (reprint author), USA, CTR CHEM RES DEV & ENGN, RES DIRECTORATE, DIV PHYS, ABERDEEN PROVING GROUND, MD 21010 USA. RI Cramer, Christopher/B-6179-2011 OI Cramer, Christopher/0000-0001-5048-1859 NR 78 TC 47 Z9 47 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0002-7863 J9 J AM CHEM SOC JI J. Am. Chem. Soc. PD MAR 27 PY 1991 VL 113 IS 7 BP 2439 EP 2447 DI 10.1021/ja00007a014 PG 9 WC Chemistry, Multidisciplinary SC Chemistry GA FD837 UT WOS:A1991FD83700014 ER PT J AU RAO, DVGLN ARANDA, FJ ROACH, JF REMY, DE AF RAO, DVGLN ARANDA, FJ ROACH, JF REMY, DE TI 3RD-ORDER, NONLINEAR OPTICAL INTERACTIONS OF SOME BENZPORPHYRINS SO APPLIED PHYSICS LETTERS LA English DT Article AB We measured third-order, nonlinear optical susceptibility chi(3) for a series of tetrabenzporphyrins in solution in tetrahydrofuran at 532 nm using degenerate four-wave mixing with picosecond pulses and obtained values of molecular second hyperpolarizability . The corresponding macroscopic chi(3) values calculated for nine compounds with different substituent groups are four to five orders larger than CS2. For five of the compounds the chi(3) values are in the range 1.2-2.8 X 10(-8) esu. Our experiments indicate that the nonlinearity is predominately electronic in origin with a response time faster than the 15 ps resolution of our system. C1 USA,CTR DEV & ENGN,NATICK,MA 01760. RP RAO, DVGLN (reprint author), UNIV MASSACHUSETTS,DEPT PHYS,AMHERST,MA 01003, USA. RI Rao, Devulapalli/L-8863-2015 NR 12 TC 121 Z9 124 U1 0 U2 1 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD MAR 25 PY 1991 VL 58 IS 12 BP 1241 EP 1243 DI 10.1063/1.104323 PG 3 WC Physics, Applied SC Physics GA FD368 UT WOS:A1991FD36800006 ER PT J AU BLANCK, RR BELL, WH AF BLANCK, RR BELL, WH TI MEDICAL SUPPORT FOR AMERICAN TROOPS IN THE PERSIAN GULF SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Editorial Material RP BLANCK, RR (reprint author), USA,FALLS CHURCH,VA 22041, USA. NR 0 TC 14 Z9 14 U1 0 U2 0 PU MASS MEDICAL SOC PI BOSTON PA 10 SHATTUCK, BOSTON, MA 02115 SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD MAR 21 PY 1991 VL 324 IS 12 BP 857 EP 859 DI 10.1056/NEJM199103213241228 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA FC442 UT WOS:A1991FC44200035 PM 1997865 ER PT J AU GASSER, RA MAGILL, AJ OSTER, CN TRAMONT, EC AF GASSER, RA MAGILL, AJ OSTER, CN TRAMONT, EC TI THE THREAT OF INFECTIOUS-DISEASE IN AMERICANS RETURNING FROM OPERATION DESERT STORM SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Article ID CONGO HEMORRHAGIC-FEVER; SAUDI-ARABIA; CUTANEOUS LEISHMANIASIS; NOSOCOMIAL OUTBREAK; TYPHOID-FEVER; WILD ANIMALS; CLINICAL EFFICACY; DRUG-RESISTANCE; WESTERN REGION; KUWAIT C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. RP GASSER, RA (reprint author), WALTER REED ARMY MED CTR,INFECT DIS SERV,WASHINGTON,DC 20307, USA. NR 89 TC 40 Z9 40 U1 0 U2 0 PU MASS MEDICAL SOC PI BOSTON PA 10 SHATTUCK, BOSTON, MA 02115 SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD MAR 21 PY 1991 VL 324 IS 12 BP 859 EP 864 DI 10.1056/NEJM199103213241229 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA FC442 UT WOS:A1991FC44200036 PM 1997866 ER PT J AU BENTON, BJ CHANG, FCT HEWETSON, JF AF BENTON, BJ CHANG, FCT HEWETSON, JF TI REVERSAL OF SAXITOXIN-INDUCED CARDIORESPIRATORY FAILURE BY BURRO IGG ANTIBODY AND OXYGEN-THERAPY SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,MED RES INST CHEM DEF,DIV PATHOPHYSIOL,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 1 Z9 1 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1478 EP A1478 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55700117 ER PT J AU BOWERSOX, SL HARRIS, LW ANDERSON, DR PASTELAK, AM VANDERPOOL, BA LENNOX, WJ AF BOWERSOX, SL HARRIS, LW ANDERSON, DR PASTELAK, AM VANDERPOOL, BA LENNOX, WJ TI ACETYLCHOLINESTERASE INHIBITION AND ANTI-SOMAN EFFICACY OF HOMOLOGS OF PHYSOSTIGMINE SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1599 EP A1599 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55700826 ER PT J AU BRUGH, SA DAVE, JR BERNTON, E RHODES, CS BURBELO, PD YAMADA, Y CHIANG, PK AF BRUGH, SA DAVE, JR BERNTON, E RHODES, CS BURBELO, PD YAMADA, Y CHIANG, PK TI MOLECULAR MIMICRY OF THE ACTION OF INSULIN IN PROMOTING CELLULAR OBESITY IN 3T3-L1 FIBROBLASTS BY AN INDIRECT INHIBITOR OF METHYLATION, 3-DEAZAADENOSINE SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NIDR,BETHESDA,MD 20892. NR 1 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1664 EP A1664 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55701210 ER PT J AU CARRYL, O SJOGREN, R GARCIA, F AF CARRYL, O SJOGREN, R GARCIA, F TI RICIN INDUCES INCREASED K+ CONDUCTANCE IN RABBIT ILEAL SMOOTH-MUSCLE SO FASEB JOURNAL LA English DT Meeting Abstract C1 UNIFORMED SERV UNIV HLTH SCI,SCH MED,DEPT MED,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,DEPT MED,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1736 EP A1736 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55701627 ER PT J AU CHIANG, PK BRUGH, SA GORDON, RK ESTRADA, JS BURBELO, PD YAMADA, Y AF CHIANG, PK BRUGH, SA GORDON, RK ESTRADA, JS BURBELO, PD YAMADA, Y TI SPECIFIC ACTIVATION OF THE COLLAGEN-IV PROMOTER-ENHANCER IN F9 TERATOCARCINOMA CELLS BY 3-DEAZAADENOSINE ANALOGS SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NIDR,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1650 EP A1650 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55701128 ER PT J AU DOCTOR, BP CASTRO, C DELAHOZ, D FINGER, A GOLD, G HIVELEY, H MAXWELL, D MCMASTER, S SOLANA, R WOLFE, AD WOODARD, C AF DOCTOR, BP CASTRO, C DELAHOZ, D FINGER, A GOLD, G HIVELEY, H MAXWELL, D MCMASTER, S SOLANA, R WOLFE, AD WOODARD, C TI PROTECTION OF MONKEYS AGAINST SOMAN TOXICITY USING ACETYLCHOLINESTERASE AS A PRETREATMENT DRUG SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1599 EP A1599 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55700825 ER PT J AU DONG, CR WANG, XJ XIANG, JM COSGRIFF, TM AF DONG, CR WANG, XJ XIANG, JM COSGRIFF, TM TI KINETIC CHANGES OF COAGULATION-ANTICOAGULATION AND FIBRINOLYTIC SYSTEM OF PATIENTS WITH EPIDEMIC HEMORRHAGIC-FEVER SO FASEB JOURNAL LA English DT Meeting Abstract C1 HUBEI MED COLL,WUHAN CITY,PEOPLES R CHINA. USA,MED RES INST INFECT DIS,FREDERICK,MD 21701. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1628 EP A1628 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55700997 ER PT J AU EDWARDS, JSA KING, N FULCO, CS ASKEW, EW AF EDWARDS, JSA KING, N FULCO, CS ASKEW, EW TI FOOD-INTAKE AND ACCEPTABILITY OF UNACCLIMATIZED US SOLDIERS LIVING AND WORKING AT ALTITUDE SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1666 EP A1666 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55701218 ER PT J AU IANNOLI, P LUND, N PEARCE, FJ AF IANNOLI, P LUND, N PEARCE, FJ TI RELATIONSHIP OF MEAN ARTERIAL-PRESSURE (MAP) TO HEPATIC TISSUE PO2 (HPO2) AND ETHANOL CLEARANCE (CLETOH) DURING GRADED HEMORRHAGE SO FASEB JOURNAL LA English DT Meeting Abstract C1 UNIV ROCHESTER,SCH MED & DENT,ROCHESTER,NY 14642. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1502 EP A1502 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55700256 ER PT J AU KAMIMORI, GH PENETAR, DM CHAMBERLAIN, AC BRUNHART, GE BRUNHART, AE AF KAMIMORI, GH PENETAR, DM CHAMBERLAIN, AC BRUNHART, GE BRUNHART, AE TI THE EFFECTS OF 48 HOURS OF SLEEP-DEPRIVATION ON CAFFEINE (CAF) PHARMACOKINETICS (PK) IN MAN SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,DEPT BEHAV BIOL,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1567 EP A1567 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55700641 ER PT J AU KIANG, JG LITTEN, RZ AF KIANG, JG LITTEN, RZ TI HEAT-INDUCED HEAT-SHOCK PROTEIN 70KD PRODUCTION AND ITS EFFECT ON CYTOSOLIC FREE [CA2+] IN HUMAN EPIDERMOID A-431 CELLS SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,DEPT CLIN PHYSIOL,DIV MED,WASHINGTON,DC 20307. NIAAA,ROCKVILLE,MD 20852. NR 0 TC 1 Z9 1 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1618 EP A1618 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55700938 ER PT J AU MATYAS, GR FISHMAN, PH AF MATYAS, GR FISHMAN, PH TI ENDOGENOUS GANGLIOSIDES DO NOT MODULATE BUT ARE MODULATED BY CELL-GROWTH IN MURINE 3T3 CELLS SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,DEPT MEMBRANE BIOCHEM,WASHINGTON,DC 20307. NINCDS,LMCN,MEMBRANE BIOCHEM SECT,BETHESDA,MD 20892. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1547 EP A1547 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55700521 ER PT J AU MOORE, RJ PATTON, JF ASKEW, EW MELLO, RP AF MOORE, RJ PATTON, JF ASKEW, EW MELLO, RP TI EFFECTS OF DIETARY CARBOHYDRATE INTAKE ON PERCEPTUAL RESPONSES TO PROLONGED LOAD-CARRIAGE EXERCISE SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1657 EP A1657 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55701164 ER PT J AU MUNDIE, TG DODD, KT AF MUNDIE, TG DODD, KT TI THE RELATIONSHIP OF TREADMILL SPEED AND GRADE ON OXYGEN-CONSUMPTION DURING INCREMENTAL EXERCISE IN SHEEP SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,DEPT RESP RES,WASHINGTON,DC 20307. NR 0 TC 1 Z9 1 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1657 EP A1657 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55701166 ER PT J AU TOWNSEND, AT KIRBY, AW POPE, CD LANOUE, BA TAPIA, TA LOPEZ, JB ESPEJO, R AF TOWNSEND, AT KIRBY, AW POPE, CD LANOUE, BA TAPIA, TA LOPEZ, JB ESPEJO, R TI EFFECT OF PHOTOPERIOD ON BLOOD ACETYLCHOLINESTERASE ACTIVITY AND MELATONIN IN ADULT CATS SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,AEROMED RES LAB,FT RUCKER,AL 36360. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1599 EP A1599 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55700829 ER PT J AU VELOSO, D DENNY, S MCKEE, K HOCHSTEIN, DH AF VELOSO, D DENNY, S MCKEE, K HOCHSTEIN, DH TI IRREVERSIBLE SHOCK IN ENDOTOXIN-TREATED RHESUS MACAQUES CORRELATES WITH PROLONGED HIGH PLASMA-LEVELS OF TUMOR-NECROSIS-FACTOR (TNF) SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,MED RES INST INFECT DIS,FREDERICK,MD 21702. NIH,CBER,BETHESDA,MD 20892. NR 0 TC 2 Z9 2 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1619 EP A1619 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55700944 ER PT J AU VILLANUEVA, C PEARCE, F WIESMANN, W AF VILLANUEVA, C PEARCE, F WIESMANN, W TI L-NG-NITRO ARGININE (L-NOARG) ARRESTS THE PROGRESS OF DECOMPENSATION DURING HEMORRHAGIC-SHOCK SO FASEB JOURNAL LA English DT Meeting Abstract C1 ESCUELA MED MIL,MEXICO CITY,MEXICO. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1502 EP A1502 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55700259 ER PT J AU WIESMANN, W VILLANUEVA, C PEARCE, F AF WIESMANN, W VILLANUEVA, C PEARCE, F TI EFFECT OF DEFEROXAMINE-CONJUGATE (DFOC) ON THE RATE OF DECOMPENSATION DURING HEMORRHAGIC-SHOCK (HS) SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. ESCUELA MED MIL,MEXICO CITY,MEXICO. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1503 EP A1503 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55700262 ER PT J AU WOLFE, AD MAXWELL, DM RAVEH, L ASHANI, Y DOCTOR, BP AF WOLFE, AD MAXWELL, DM RAVEH, L ASHANI, Y DOCTOR, BP TI INVIVO DETOXIFICATION OF ORGANOPHOSPHATE IN MARMOSETS BY FETAL BOVINE SERUM ACETYLCHOLINESTERASE SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010. ISRAEL INST BIOL RES,IL-70450 NESS ZIONA,ISRAEL. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 19 PY 1991 VL 5 IS 6 BP A1599 EP A1599 PN 3 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FE557 UT WOS:A1991FE55700827 ER PT J AU LAUGHLIN, T WAAG, D WILLIAMS, J MARRIE, T AF LAUGHLIN, T WAAG, D WILLIAMS, J MARRIE, T TI Q-FEVER - FROM DEER TO DOG TO MAN SO LANCET LA English DT Letter C1 USA,MED RES INST INFECT DIS,DIV BACTERIOL,FREDERICK,MD 21701. NIAID,BETHESDA,MD 20892. DALHOUSIE UNIV,DEPT MED,HALIFAX B3H 2Y9,NS,CANADA. DALHOUSIE UNIV,DEPT MICROBIOL,HALIFAX B3H 2Y9,NS,CANADA. RP LAUGHLIN, T (reprint author), MONCTON CITY HOSP,DEPT FAMILY PRACTICE,MONCTON,NB,CANADA. NR 2 TC 24 Z9 26 U1 0 U2 1 PU LANCET LTD PI LONDON PA 42 BEDFORD SQUARE, LONDON, ENGLAND WC1B 3SL SN 0140-6736 J9 LANCET JI Lancet PD MAR 16 PY 1991 VL 337 IS 8742 BP 676 EP 677 DI 10.1016/0140-6736(91)92494-M PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA FB730 UT WOS:A1991FB73000039 PM 1672016 ER PT J AU SJOGREN, MH HOKE, CH BINN, LN ECKELS, KH DUBOIS, DR TSUCHIDA, A OAKS, S MARCHWICKI, R LEDNAR, W CHLOUPEK, R TICEHURST, J BANCROFT, WH AF SJOGREN, MH HOKE, CH BINN, LN ECKELS, KH DUBOIS, DR TSUCHIDA, A OAKS, S MARCHWICKI, R LEDNAR, W CHLOUPEK, R TICEHURST, J BANCROFT, WH TI IMMUNOGENICITY OF AN INACTIVATED HEPATITIS-A VACCINE SO ANNALS OF INTERNAL MEDICINE LA English DT Note ID NEUTRALIZING ANTIBODY; VIRUS C1 USA,MAT DEV ACT,FREDERICK,MD 21701. RP SJOGREN, MH (reprint author), WALTER REED ARMY MED CTR,DEPT VIRUS DIS,WASHINGTON,DC 20307, USA. RI Ticehurst, John/I-7532-2012 NR 5 TC 38 Z9 39 U1 0 U2 3 PU AMER COLL PHYSICIANS PI PHILADELPHIA PA INDEPENDENCE MALL WEST 6TH AND RACE ST, PHILADELPHIA, PA 19106-1572 SN 0003-4819 J9 ANN INTERN MED JI Ann. Intern. Med. PD MAR 15 PY 1991 VL 114 IS 6 BP 470 EP 471 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA FB640 UT WOS:A1991FB64000007 PM 1994794 ER PT J AU RUAN, KH STILES, BG ATASSI, MZ AF RUAN, KH STILES, BG ATASSI, MZ TI THE SHORT-NEUROTOXIN-BINDING REGIONS ON THE ALPHA-CHAIN OF HUMAN AND TORPEDO-CALIFORNICA ACETYLCHOLINE-RECEPTORS SO BIOCHEMICAL JOURNAL LA English DT Article ID COMPREHENSIVE SYNTHETIC APPROACH; EXTRACELLULAR PART; SEA SNAKE; 3-DIMENSIONAL STRUCTURE; HUMAN-HEMOGLOBIN; ANTIGENIC SITES; FULL PROFILE; ERABUTOXIN-B; LOCALIZATION; PROTEIN AB The continuous regions for short-neurotoxin binding on the alpha-chains of Torpedo californica (electric ray) and human acetylcholine receptors (AChR) were localized by reaction of I-125-labelled cobrotoxin (Cot) and erabutoxin b (Eb) with synthetic overlapping peptides spanning the entire extracellular part of the respective alpha-chains. On Torpedo AChR, five Cot-binding regions were found to reside within peptides alpha-1-16, alpha-23-38/alpha-34-49 overlap, alpha-100-115, alpha-122-138 and alpha-194-210. The Eb-binding regions were localized within peptides alpha-23-38/alpha-34-49/alpha-45-60 overlap, alpha-100-115 and alpha-122-138. The main binding activity for both toxins resided within region alpha-122-138. In previous studies we had shown that the binding of long alpha-neurotoxins [alpha-bungarotoxin (Bgt) and cobratoxin (Cbt)] involved the same regions on Torpedo AChR as well as an additional region within residues alpha-182-198. Thus region alpha-182-198, which is the strongest binding region for long neurotoxins on Torpedo AChR, was not a binding region for short neurotoxins. On human AChR, peptide alpha-122-138 possessed the highest activity with both toxins, and lower activity was found in the overlap alpha-23-38/alpha-34-49/alpha-45-60 and in peptide alpha-194-210. In addition, peptides alpha-100-115 and alpha-56-71 showed strong and medium binding activities to Eb, but low activity to Cot, whereas peptide alpha-1-16 exhibited low binding to Cot and no binding to Eb. Comparison with previous studies indicated that, for human AChR, the binding regions of short and long neurotoxins were essentially the same. The finding that the region within residues alpha-122-138 of both human and Torpedo AChR possessed the highest binding activity with short neurotoxins indicated that this region constitutes a universal binding site for long and short neurotoxins on AChR from various species. C1 BAYLOR UNIV,DEPT BIOCHEM,1 BAYLOR PLAZA,HOUSTON,TX 77030. USA,MED RES INST INFECT DIS,FREDERICK,MD 21701. FU NINDS NIH HHS [NS 26280] NR 44 TC 47 Z9 47 U1 0 U2 0 PU PORTLAND PRESS PI LONDON PA 59 PORTLAND PLACE, LONDON, ENGLAND W1N 3AJ SN 0264-6021 J9 BIOCHEM J JI Biochem. J. PD MAR 15 PY 1991 VL 274 BP 849 EP 854 PN 3 PG 6 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA FD379 UT WOS:A1991FD37900031 PM 2012611 ER PT J AU DOW, N AF DOW, N TI CD8/CD57 LYMPHOCYTOSIS IN COMMON VARIABLE IMMUNODEFICIENCY SO BLOOD LA English DT Letter RP DOW, N (reprint author), WALTER REED ARMY MED CTR,DEPT PATHOL,WASHINGTON,DC 20307, USA. NR 3 TC 1 Z9 1 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0006-4971 J9 BLOOD JI Blood PD MAR 15 PY 1991 VL 77 IS 6 BP 1400 EP 1401 PG 2 WC Hematology SC Hematology GA FB731 UT WOS:A1991FB73100041 PM 1705840 ER PT J AU HOWARD, SL AF HOWARD, SL TI ANALYSIS OF THE ENERGY WINDOW FOR THE QUANTUM-STATE AND ANGULAR SCATTERING SPECIFICITY IN AR+ CHARGE-TRANSFER WITH N2 SO CHEMICAL PHYSICS LETTERS LA English DT Article ID CROSSED-MOLECULAR-BEAM; INTERMEDIATE ENERGIES; REACTION DYNAMICS; TO-STATE; N-2 AB Previous kinematic analysis of the charge-transfer reaction of Ar+ with N2 has shown an energy window near 1 eV collision energy where quantum-specific and angular-specific scattering is observed. Reactant energy and angular distributions were used to determine the center-of-mass energy distribution from the nominal center-of-mass energies previously reported. The resultant distributions show that the maximum width of the energy "window" is 0.31 eV with a median collision energy of 0.91 eV rather than a width of 0.9 eV with a median energy near 1 eV as previously reported. RP HOWARD, SL (reprint author), USA,BALLIST RES LABS,ABERDEEN PROVING GROUND,MD 21005, USA. NR 18 TC 3 Z9 3 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0009-2614 J9 CHEM PHYS LETT JI Chem. Phys. Lett. PD MAR 15 PY 1991 VL 178 IS 1 BP 65 EP 68 DI 10.1016/0009-2614(91)85054-Z PG 4 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA FB896 UT WOS:A1991FB89600011 ER PT J AU BAKER, CJ HOYT, RW JONES, TE ASKEW, EW AF BAKER, CJ HOYT, RW JONES, TE ASKEW, EW TI VOLUNTARY CONSUMPTION OF A CARBOHYDRATE (CHO) SUPPLEMENT BY SOLDIERS DURING A WINTER CLIMB ON MOUNT RAINIER SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,INST ENVIRONM MED,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1128 EP A1128 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55001218 ER PT J AU BLANCHARD, LA KOLKA, MA STEPHENSON, LA AF BLANCHARD, LA KOLKA, MA STEPHENSON, LA TI COMPARISON OF RECTAL (TRE), ESOPHAGEAL (TES) AND PILL TEMPERATURE (TP) AS A CIRCADIAN CORE TEMPERATURE (TC) INDICATOR IN HUMANS SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. NR 0 TC 3 Z9 3 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1125 EP A1125 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55001203 ER PT J AU BOYLE, T JETT, M AF BOYLE, T JETT, M TI STAPHYLOCOCCAL ENTEROTOXIN-B (SEB) ALTERS ARACHIDONATE METABOLISM IN HUMAN LUNG-CELLS SO FASEB JOURNAL LA English DT Meeting Abstract C1 GEORGETOWN UNIV,DEPT CHEM,WASHINGTON,DC 20057. WALTER REED ARMY MED CTR,DIV PATHOL,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1158 EP A1158 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55001393 ER PT J AU CALVERT, RJ SATCHITHANANDAM, S SCHAUDIES, RP AF CALVERT, RJ SATCHITHANANDAM, S SCHAUDIES, RP TI CONSUMPTION OF DIETARY-FIBERS WITH DIFFERENT POTENTIALS TO ALTER COLONIC CARCINOGENESIS DIFFERENTIALLY AFFECTS COLONIC LUMINAL IMMUNOREACTIVE EGF LEVELS IN RATS SO FASEB JOURNAL LA English DT Meeting Abstract C1 US EPA,WASHINGTON,DC 20460. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1083 EP A1083 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55000963 ER PT J AU CAPACIO, BR HARRIS, LW ANDERSON, DR LENNOX, WJ GALES, V DAWSON, JS AF CAPACIO, BR HARRIS, LW ANDERSON, DR LENNOX, WJ GALES, V DAWSON, JS TI ASSESSMENT OF ANTICONVULSANT-INDUCED MOTOR-PERFORMANCE DECREMENT IN RATS SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,MED RES INST,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1212 EP A1212 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55001709 ER PT J AU DHILLON, GS KOSTKA, P AF DHILLON, GS KOSTKA, P TI CORTICOTROPIN RELEASING HORMONE - PUTATIVE NEUROMODULATOR IN THE CANINE MYENTERIC PLEXUS SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 1 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1238 EP A1238 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55001863 ER PT J AU FORTE, VA FULCO, CS MEADOWS, PL GONZALEZ, J CYMERMAN, A AF FORTE, VA FULCO, CS MEADOWS, PL GONZALEZ, J CYMERMAN, A TI PULMONARY-FUNCTION IN SMOKERS AND NONSMOKERS AT HIGH-ALTITUDE SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,INST ENVIRONM MED,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1128 EP A1128 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55001222 ER PT J AU FULCO, CS FRIEDL, KE CYMERMAN, A AF FULCO, CS FRIEDL, KE CYMERMAN, A TI THE USE OF DUAL-ENERGY X-RAY ABSORPTIOMETRY (DEXA) FOR THE ASSESSMENT OF BODY-COMPOSITION BEFORE AND AFTER AN ALTITUDE EXPOSURE SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,INST ENVIRONM MED,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1127 EP A1127 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55001216 ER PT J AU GORDON, RK STEELE, LN REAVES, CB DUERRE, JA AF GORDON, RK STEELE, LN REAVES, CB DUERRE, JA TI EFFECT OF S-ADENOSYLMETHIONINE (ADOMET) ON THE MEMBRANE FLUIDITY OF HL-60 CELLS SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. UNIV N DAKOTA,SCH MED,GRAND FORKS,ND 58202. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1053 EP A1053 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55000797 ER PT J AU GUO, ZM LIU, CT PETERS, CJ AF GUO, ZM LIU, CT PETERS, CJ TI POSSIBLE INVOLVEMENT OF CEREBROSPINAL-FLUID BETA-ENDORPHIN IN THE PATHOGENESIS OF PICHINDE VIRAL-INFECTION IN GUINEA-PIGS SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,MED RES INST INFECT DIS,FT DETRICK,MD 21702. NR 3 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1225 EP A1225 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55001788 ER PT J AU HOYT, RW JONES, TE SCHWARTZ, R SCHOENE, RB SCHOELLER, DA ASKEW, EW CYMERMAN, A AF HOYT, RW JONES, TE SCHWARTZ, R SCHOENE, RB SCHOELLER, DA ASKEW, EW CYMERMAN, A TI DOUBLY LABELED WATER (DLW) MEASUREMENT OF HUMAN ENERGY-EXPENDITURE (EE) DURING A WINTER CLIMB ON MT RAINIER SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,INST ENVIRONM MED,NATICK,MA 01760. UNIV WASHINGTON,DEPT MED,SEATTLE,WA 98195. UNIV CHICAGO,CTR CLIN NUTR,CHICAGO,IL 60637. NR 0 TC 1 Z9 1 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1127 EP A1127 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55001214 ER PT J AU JARBOE, D REID, R KODAK, J NAUSS, J CASSELS, F CARTER, J DEAL, C BOEDEKER, E AF JARBOE, D REID, R KODAK, J NAUSS, J CASSELS, F CARTER, J DEAL, C BOEDEKER, E TI IDENTIFICATION AND LOCALIZATION OF T-CELL EPITOPES OF CFA/I USING LYMPHOCYTE-PROLIFERATION TO SYNTHETIC PEPTIDES PRODUCED BY MULTIPLE PEPTIDE-SYNTHESIS SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. RI Carter, John Mark/K-2485-2015 OI Carter, John Mark/0000-0001-8251-4168 NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1362 EP A1362 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55002578 ER PT J AU JONES, TE HOYT, RW HNILCKA, J SCHOELLER, DA SCHOENE, RB ASKEW, EW CYMERMAN, A AF JONES, TE HOYT, RW HNILCKA, J SCHOELLER, DA SCHOENE, RB ASKEW, EW CYMERMAN, A TI DEUTERIUM-OXIDE (H2O)-H2 MEASUREMENT OF WATER-INTAKE DURING A WINTER CLIMB ON MT RAINIER SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,INST ENVIRONM MED,NATICK,MA 01760. UNIV WASHINGTON,DEPT MED,SEATTLE,WA 98195. UNIV CHICAGO,CTR CLIN NUTR,CHICAGO,IL 60637. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1127 EP A1127 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55001217 ER PT J AU KIM, IK KWON, OJ BROWN, ND CHIANG, PK GORDON, RK AF KIM, IK KWON, OJ BROWN, ND CHIANG, PK GORDON, RK TI DECARBOXYLATION OF S-ADENOSYLHOMOCYSTEINE SO FASEB JOURNAL LA English DT Meeting Abstract C1 CATHOLIC UNIV SEOUL,COLL MED,DEPT BIOCHEM,SEOUL,SOUTH KOREA. WALTER REED ARMY MED CTR,DIV BIOCHEM,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1210 EP A1210 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55001699 ER PT J AU KING, A INNIS, B CAUDLE, L KULYANARUJ, S PATTANAPANYASAT, K NISALAK, A AF KING, A INNIS, B CAUDLE, L KULYANARUJ, S PATTANAPANYASAT, K NISALAK, A TI B-CELLS ARE THE PRINCIPAL CIRCULATING MONONUCLEAR-CELLS INFECTED BY DENGUE VIRUS SO FASEB JOURNAL LA English DT Meeting Abstract C1 ARMED FORCES RES INST MED SCI,BANGKOK,THAILAND. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A988 EP A988 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55000415 ER PT J AU KOLKA, MA STEPHENSON, LA AF KOLKA, MA STEPHENSON, LA TI CHEST AND FOREARM BLOOD-FLOW RESPONSES DURING EXERCISE IN A WARM ENVIRONMENT SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1400 EP A1400 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55002802 ER PT J AU KOSTKA, P GORDON, RK CHIANG, PK DHILLON, GS AF KOSTKA, P GORDON, RK CHIANG, PK DHILLON, GS TI ADENYLATE-CYCLASE ACTIVITY IN SMOOTH-MUSCLE PLASMALEMMA - EFFECT OF INHIBITION OF MEMBRANE-BOUND MG2+-ATPASE SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1238 EP A1238 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55001861 ER PT J AU LAPLACA, MC MEYERHOFF, JL REPASI, RT YOURICK, DL AF LAPLACA, MC MEYERHOFF, JL REPASI, RT YOURICK, DL TI NOREPINEPHRINE-STIMULATED PHOSPHATIDYLINOSITOL METABOLISM IN CORTEX OF AUDIOGENICALLY SEIZURE SENSITIVE DBA/2 AND NORMAL C57BL/6 MICE SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,DEPT MED NEUROSCI,WASHINGTON,DC 20307. NR 1 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1211 EP A1211 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55001704 ER PT J AU LEMLEY, PV RIVERA, VR AMANATIDES, P HEWETSON, JF POLI, MA AF LEMLEY, PV RIVERA, VR AMANATIDES, P HEWETSON, JF POLI, MA TI CHARACTERIZATION OF POLYCLONAL AND MONOCLONAL ANTI-RICIN IMMUNOGLOBULIN INVITRO AND INVIVO SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,MED RES INST INFECT DIS,FREDERICK,MD 21701. NR 0 TC 1 Z9 1 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1206 EP A1206 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55001677 ER PT J AU LIU, CT PEARSON, MA PARKER, GW AF LIU, CT PEARSON, MA PARKER, GW TI APPLICATIONS OF A TELEMETRIC SYSTEM FOR REMOTE MONITORING OF PHYSIOLOGICAL FUNCTIONS IN CONSCIOUS RHESUS-MONKEYS SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,MED RES INST INFECT DIS,FREDERICK,MD 21702. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1141 EP A1141 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55001295 ER PT J AU MALIK, A EGAN, JE HOFFMAN, SL AF MALIK, A EGAN, JE HOFFMAN, SL TI CYTOTOXIC LYMPHOCYTE-T AGAINST THE PLASMODIUM-FALCIPARUM CIRCUMSPOROZOITE PROTEIN SO FASEB JOURNAL LA English DT Meeting Abstract C1 USN,MED RES INST,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1376 EP A1376 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55002658 ER PT J AU MATTHEW, C AF MATTHEW, C TI AMBIENT-TEMPERATURE EFFECTS OF PHYSOSTIGMINE IN EXERCISING RATS SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1401 EP A1401 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55002808 ER PT J AU MAYORGA, MA MATYAS, GR WILHELMSEN, CL BANKS, RE ALVING, CR AF MAYORGA, MA MATYAS, GR WILHELMSEN, CL BANKS, RE ALVING, CR TI ACUTE RESPIRATORY INJURY INDUCED BY ENDOTRACHEALLY INSTILLED SNAKE-VENOM PHOSPHOLIPASE-A2 (PLA2) SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1268 EP A1268 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55002035 ER PT J AU MOODY, JM RUBAL, BJ BAILEY, SR KONO, A AF MOODY, JM RUBAL, BJ BAILEY, SR KONO, A TI EFFECTS OF AMYL NITRITE INHALATION (ANI) ON CARDIAC DYNAMICS - IMPLICATIONS FOR BEDSIDE DIAGNOSIS SO FASEB JOURNAL LA English DT Meeting Abstract C1 BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234. USAF,BROOKS AFB,TX 78235. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1437 EP A1437 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55003015 ER PT J AU NASEEM, SM PACE, JG AF NASEEM, SM PACE, JG TI EFFECTS OF RICIN ON MACROMOLECULAR-SYNTHESIS AND ARACHIDONIC-ACID METABOLISM IN CULTURED MACROPHAGES SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,MED RES INST INFECT DIS,FREDERICK,MD 21702. NR 0 TC 0 Z9 0 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1272 EP A1272 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55002060 ER PT J AU RUBAL, BJ MOODY, JM BAILEY, SR AF RUBAL, BJ MOODY, JM BAILEY, SR TI BARORECEPTOR SENSITIVITY IN SUPINE MAN FOLLOWING INHALATION OF AMYL NITRITE SO FASEB JOURNAL LA English DT Meeting Abstract C1 BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234. UNIV TEXAS,HLTH SCI CTR,SAN ANTONIO,TX 78284. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1414 EP A1414 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55002883 ER PT J AU SHIPPEE, R BOOSALIS, M MCCLAIN, C BECKER, W WATIWAT, S AF SHIPPEE, R BOOSALIS, M MCCLAIN, C BECKER, W WATIWAT, S TI EFFECT OF TOPICAL SILVER SULFADIAZINE ON PLASMA COOPER, ZINC AND SILVER CONCENTRATIONS IN A BURN RAT MODEL SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,INST SURG RES,FT SAM HOUSTON,TX 78234. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1313 EP A1313 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55002295 ER PT J AU SZLYK, PC SILS, IV MAHNKE, RB ARMSTRONG, LE AF SZLYK, PC SILS, IV MAHNKE, RB ARMSTRONG, LE TI HEAT TOLERANCE IN PRIOR EXERTIONAL HEATSTROKE PATIENTS SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 15 PY 1991 VL 5 IS 5 BP A1400 EP A1400 PN 2 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC550 UT WOS:A1991FC55002801 ER PT J AU KRUEGER, RR SLINEY, DH TROKEL, SL AF KRUEGER, RR SLINEY, DH TROKEL, SL TI PHOTOKERATITIS FROM SUBABLATIVE EXPOSURE OF 193NM EXCIMER LASER-LIGHT SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 COLUMBIA PRESBYTERIAN MED CTR,HARKNESS EYE INST,NEW YORK,NY 10032. USA,ENVIRONM HYG AGCY,DIV LASER MICROWAVE,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 721 EP 721 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76200278 ER PT J AU BILLOCK, VA HARDING, TH AF BILLOCK, VA HARDING, TH TI THE NUMBER AND TUNING OF CHANNELS RESPONSIBLE FOR THE INDEPENDENT DETECTION OF TEMPORAL-MODULATION SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE LA English DT Meeting Abstract C1 USA,AEROMED RES LAB,FT RUCKER,AL 36360. NR 1 TC 3 Z9 3 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0404 J9 INVEST OPHTH VIS SCI JI Invest. Ophthalmol. Vis. Sci. PD MAR 15 PY 1991 VL 32 IS 4 BP 840 EP 840 PG 1 WC Ophthalmology SC Ophthalmology GA FC762 UT WOS:A1991FC76200849 ER PT J AU TUCKER, WB GRENFELL, TC ONSTOTT, RG PEROVICH, DK GOW, AJ SHUCHMAN, RA SUTHERLAND, LL AF TUCKER, WB GRENFELL, TC ONSTOTT, RG PEROVICH, DK GOW, AJ SHUCHMAN, RA SUTHERLAND, LL TI MICROWAVE AND PHYSICAL-PROPERTIES OF SEA ICE IN THE WINTER MARGINAL ICE-ZONE SO JOURNAL OF GEOPHYSICAL RESEARCH-OCEANS LA English DT Article ID FREQUENCIES; PARAMETERS AB Surface-based active and passive microwave measurements were made in conjunction with ice property measurements for several distinct ice types in the Fram Strait during March and April 1987. Synthetic aperture radar imagery downlinked from an aircraft was used to select study sites. The surface-based radar scattering cross section and emissivity spectra generally support previously inferred qualitative relationships between ice types, exhibiting expected separation between young, first-year and multiyear ice. Gradient ratios, calculated for both active and passive data, appear to allow clear separation of ice types when used jointly. Surface flooding of multiyear floes, resulting from excessive loading and perhaps wave action, causes both active and passive signatures to resemble those of first-year ice. This effect could possibly cause estimates of ice type percentages in the marginal ice zone to be in error when derived from aircraft- or satellite-borne sensors. C1 UNIV WASHINGTON,DEPT ATMOSPHER SCI,AK-40,SEATTLE,WA 98195. ENVIRONM RES INST MICHIGAN,ANN ARBOR,MI 48107. RP TUCKER, WB (reprint author), USA,COLD REG RES & ENGN LAB,LYME RD,HANOVER,NH 03755, USA. NR 19 TC 33 Z9 35 U1 0 U2 1 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 SN 0148-0227 J9 J GEOPHYS RES-OCEANS JI J. Geophys. Res.-Oceans PD MAR 15 PY 1991 VL 96 IS C3 BP 4573 EP 4587 DI 10.1029/90JC02269 PG 15 WC Oceanography SC Oceanography GA FC252 UT WOS:A1991FC25200005 ER PT J AU HAMMACK, J SCHEFFNER, N SEGUR, H AF HAMMACK, J SCHEFFNER, N SEGUR, H TI A NOTE ON THE GENERATION AND NARROWNESS OF PERIODIC RIP CURRENTS SO JOURNAL OF GEOPHYSICAL RESEARCH-OCEANS LA English DT Article ID WAVES AB Periodic rip currents on a wide planar beach are generated in the laboratory by shoaling water waves that are periodic in time and in two spatial directions: one normal (x direction) and one parallel (y direction) to the shoreline. These short-crested waves propagate in water of uniform depth with nearly permanent form. They are described analytically by a family of solutions of the Kadomtsev-Petviashvili (KP) equation (KP solutions of genus 2). During shoaling, genus 2 waves retain their spatial pattern past breaking, and they quickly generate periodic rip currents along the beach with a spacing of one-half the y wavelength of the incident waves. KP theory also provides a plausible explanation and prediction for the narrow widths, relative to their longshore spacing, of rip currents generated in this manner. An estimate of their widths is one-half the x wavelength of the incident waves. C1 USA,COASTAL ENGN RES CTR,ENGINEER WATERWAYS EXPT STN,VICKSBURG,MS 39180. UNIV COLORADO,PROGRAM APPL MATH,BOULDER,CO 80309. RP HAMMACK, J (reprint author), UNIV FLORIDA,DEPT AEROSP ENGN MECH & ENGN SCI,GAINESVILLE,FL 32611, USA. NR 15 TC 13 Z9 13 U1 0 U2 0 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 SN 0148-0227 J9 J GEOPHYS RES-OCEANS JI J. Geophys. Res.-Oceans PD MAR 15 PY 1991 VL 96 IS C3 BP 4909 EP 4914 DI 10.1029/90JC02304 PG 6 WC Oceanography SC Oceanography GA FC252 UT WOS:A1991FC25200029 ER PT J AU NELSON, BJ RALPH, P GREEN, SJ NACY, CA AF NELSON, BJ RALPH, P GREEN, SJ NACY, CA TI DIFFERENTIAL SUSCEPTIBILITY OF ACTIVATED MACROPHAGE CYTOTOXIC EFFECTOR REACTIONS TO THE SUPPRESSIVE EFFECTS OF TRANSFORMING GROWTH FACTOR-BETA-1 SO JOURNAL OF IMMUNOLOGY LA English DT Article ID KILL LEISHMANIA-TROPICA; FACTOR TYPE-BETA; INTRACELLULAR DESTRUCTION; ANTIMICROBIAL ACTIVITIES; PERITONEAL-MACROPHAGES; CYTOKINE PRODUCTION; TUMOR CYTOTOXICITY; INTERFERON-GAMMA; IFN-GAMMA; CELLS AB We examined the effects of TGF-beta-1 on induction of several activated macrophage antimicrobial activities against the protozoan parasite Leishmania, and on induction of tumoricidal activity against the fibrosarcoma tumor target 1023. TGF-beta by itself did not affect the viability of either the intracellular or extracellular target in concentrations up to 200 ng/ml. As little as 1 ng/ml TGF-beta, however, suppressed more than 70% of the intracellular killing activity of macrophages treated with lymphokines. In contrast, more than 100 ng/ml TGF-beta was required to suppress intracellular killing by cells activated with an equivalent amount of recombinant IFN-gamma. Addition of TGF-beta for up to 30 min after exposure to activation factors significantly reduced macrophage killing of intracellular parasites. Pretreatment of macrophages with TGF-beta was even more effective: treatment of cells with TGF-beta for 4 h before addition of activation factors abolished all macrophage intracellular killing activity. Regardless of treatment sequence, however, TGF-beta had absolutely no effect, at any concentration tested, on activated macrophage resistance to infection induced by lymphokines or by the cooperative interaction of IFN-gamma and IL-4. Effects of TGF-beta on tumoricidal activity of activated macrophages was intermediate to that of its effects on intracellular killing or resistance to infection. Lymphokine-induced tumor cytotoxicity was marginally (25%) affected by TGF-beta; 200 ng/ml was able to suppress IFN-gamma-induced tumoricidal activity by 40%. Thus, TGF-beta dramatically suppressed certain activated macrophage cytotoxic effector reactions, but was only partially or not at all effective against others, even when the same activation agent (IFN-gamma) was used. The biochemical target for TGF-beta suppressive activity in these reactions may be the pathway for nitric oxide production from L-arginine, because TGF-beta also inhibited the generation of nitric oxide by cytokine-activated macrophages. C1 WALTER REED ARMY MED CTR, DEPT CELLULAR IMMUNOL, WASHINGTON, DC 20307 USA. CETUS CORP, EMERYVILLE, CA 94608 USA. NR 41 TC 136 Z9 137 U1 0 U2 0 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD MAR 15 PY 1991 VL 146 IS 6 BP 1849 EP 1857 PG 9 WC Immunology SC Immunology GA FC439 UT WOS:A1991FC43900019 PM 1900875 ER PT J AU DOYLE, FM AF DOYLE, FM TI BERMAN, LIGHTEN UP SO LIBRARY JOURNAL LA English DT Letter RP DOYLE, FM (reprint author), HQ TRADOC,FT MONROE LIB & INTERN TRAINING CTR,FT MONROE,VA, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU BOWKER MAGAZINE GROUP CAHNERS MAGAZINE DIVISION PI NEW YORK PA 249 W 17TH ST, NEW YORK, NY 10011 SN 0363-0277 J9 LIBR J JI Libr. J. PD MAR 15 PY 1991 VL 116 IS 5 BP 12 EP 12 PG 1 WC Information Science & Library Science SC Information Science & Library Science GA FC046 UT WOS:A1991FC04600009 ER PT J AU YU, FTS WU, SD MAYERS, A RAJAN, SM GREGORY, DA AF YU, FTS WU, SD MAYERS, A RAJAN, SM GREGORY, DA TI COLOR HOLOGRAPHIC STORAGE IN LINBO3 SO OPTICS COMMUNICATIONS LA English DT Article AB Experimental demonstrations of real-time color holographic storage in LiNbO3 using a "white light" laser are presented. The geometry of the recording setup and wavelength crosstalk are discussed. C1 USA,MISSILE COMMAND RES DIRECTORATE,REDSTONE ARSENAL,AL 35898. RP YU, FTS (reprint author), PENN STATE UNIV,DEPT ELECT ENGN,UNIVERSITY PK,PA 16802, USA. NR 5 TC 8 Z9 8 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0030-4018 J9 OPT COMMUN JI Opt. Commun. PD MAR 15 PY 1991 VL 81 IS 6 BP 348 EP 352 DI 10.1016/0030-4018(91)90596-6 PG 5 WC Optics SC Optics GA FF993 UT WOS:A1991FF99300003 ER PT J AU RICH, DH KSENDZOV, A TERHUNE, RW GRUNTHANER, FJ WILSON, BA SHEN, H DUTTA, M VERNON, SM DIXON, TM AF RICH, DH KSENDZOV, A TERHUNE, RW GRUNTHANER, FJ WILSON, BA SHEN, H DUTTA, M VERNON, SM DIXON, TM TI POLARIZED-CATHODOLUMINESCENCE STUDY OF UNIAXIAL AND BIAXIAL STRESS IN GAAS/SI SO PHYSICAL REVIEW B LA English DT Note ID HETEROEPITAXIAL GAAS; GALLIUM-ARSENIDE; SI; PHOTOLUMINESCENCE; SILICON; RELIEF AB The strain-induced splitting of the heavy-hole (hh) and light-hole (lh) valence bands for 4-mu-m-thick GaAs/Si is examined on a microscopic scale using linear polarized-cathodoluminescence imaging and spectroscopy. The energies and intensities of the hh- and lh-exciton luminescence are quantitatively analyzed to determine spatial variations in the stress tensor. The results indicate that regions near and far from the microcracks are primarily subject to uniaxial and biaxial tensile stresses, respectively. The transition region where biaxial stress gradually converts to uniaxial stress is analyzed, and reveals a mixing of lh and hh characters in the strain-split bands. C1 USA,ELECTR TECHNOL & DEVICES LAB,FT MONMOUTH,NJ 07703. GEOCENTERS INC,NJ OPERAT,LAKE HOPATCONG,NJ 07849. SPIRE CORP,BEDFORD,MA 01730. RP RICH, DH (reprint author), CALTECH,JET PROP LAB,CTR SPACE MICROELECTR TECHNOL,4800 OAK GROVE DR,PASADENA,CA 91109, USA. NR 19 TC 34 Z9 34 U1 0 U2 1 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0163-1829 J9 PHYS REV B JI Phys. Rev. B PD MAR 15 PY 1991 VL 43 IS 8 BP 6836 EP 6839 DI 10.1103/PhysRevB.43.6836 PG 4 WC Physics, Condensed Matter SC Physics GA FC704 UT WOS:A1991FC70400079 ER PT J AU AGNEW, JW FREUND, BJ DUBOSE, DA MCKAY, JM HASHIRO, GM AF AGNEW, JW FREUND, BJ DUBOSE, DA MCKAY, JM HASHIRO, GM TI THE ROLE OF ATRIAL NATRIURETIC PEPTIDE(ANP) IN COLD-INDUCED DIURESIS (CID) SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,INST ENVIRONM MED,NATICK,MA 01760. TRIPLER ARMY MED CTR,HONOLULU,HI 96859. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 11 PY 1991 VL 5 IS 4 BP A394 EP A394 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC207 UT WOS:A1991FC20700134 ER PT J AU ASHANI, Y BROMBERG, A SAXENA, A HUR, RS BRADY, DR GENTRY, MK WOLFE, AD DOCTOR, BP AF ASHANI, Y BROMBERG, A SAXENA, A HUR, RS BRADY, DR GENTRY, MK WOLFE, AD DOCTOR, BP TI MONOCLONAL-ANTIBODIES AS PROBES OF ACETYLCHOLINESTERASE FUNCTION SO FASEB JOURNAL LA English DT Meeting Abstract C1 ISRAEL INST BIOL RES,IL-70450 NESS ZIONA,ISRAEL. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 11 PY 1991 VL 5 IS 4 BP A465 EP A465 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC207 UT WOS:A1991FC20700544 ER PT J AU ASSAAD, A NOLD, J PETRALI, J MOORE, D MITCHELTREE, L CORCORAN, K PHILLIPS, K AF ASSAAD, A NOLD, J PETRALI, J MOORE, D MITCHELTREE, L CORCORAN, K PHILLIPS, K TI PULMONARY PATHOLOGICAL ALTERATIONS IN SHEEP EXPOSED TO A LETHAL DOSE OF PHOSGENE SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010. NR 1 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 11 PY 1991 VL 5 IS 4 BP A484 EP A484 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC207 UT WOS:A1991FC20700654 ER PT J AU BROWN, ND BUTLER, DL KATZHENDLER, J DOCTOR, BP CHIANG, PK AF BROWN, ND BUTLER, DL KATZHENDLER, J DOCTOR, BP CHIANG, PK TI THYMOPENTIN PENTAPEPTIDES ANTAGONIZE THE NICOTINIC ACTIVITY OF (+)-ANATOXIN-A ON GUINEA-PIG ILEUM SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 11 PY 1991 VL 5 IS 4 BP A857 EP A857 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC207 UT WOS:A1991FC20702826 ER PT J AU CADARETTE, BS PRUSACZYK, WK SAWKA, MN AF CADARETTE, BS PRUSACZYK, WK SAWKA, MN TI INFLUENCE OF PYRIDOSTIGMINE BROMIDE ON HUMAN THERMOREGULATION DURING COLD-WATER IMMERSION SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,INST ENVIRONM MED,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 11 PY 1991 VL 5 IS 4 BP A393 EP A393 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC207 UT WOS:A1991FC20700132 ER PT J AU CARETTI, DM SZLYK, PC SILS, IV AF CARETTI, DM SZLYK, PC SILS, IV TI INFLUENCE OF TRAINING ON VENTILATORY PATTERNS AND ENTRAINMENT SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 11 PY 1991 VL 5 IS 4 BP A766 EP A766 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC207 UT WOS:A1991FC20702298 ER PT J AU CHATTERJEE, S JETT, M AF CHATTERJEE, S JETT, M TI GLYCOSPHINGOLIPIDS - THE PUTATIVE RECEPTOR FOR STAPHYLOCOCCUS-AUREUS ENTEROTOXIN-B IN HUMAN PROXIMAL TUBULAR CELLS SO FASEB JOURNAL LA English DT Meeting Abstract C1 JOHNS HOPKINS UNIV,DEPT PEDIAT,BALTIMORE,MD 21205. WALTER REED ARMY MED CTR,DIV PATHOL,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 11 PY 1991 VL 5 IS 4 BP A822 EP A822 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC207 UT WOS:A1991FC20702621 ER PT J AU COWAN, FM BROOMFIELD, CA SMITH, WJ AF COWAN, FM BROOMFIELD, CA SMITH, WJ TI INHIBITION OF SULFUR MUSTARD-INCREASED PROTEASE ACTIVITY BY NIACINAMIDE, N-ACETYL-L-CYSTEINE OR DEXAMETHASONE SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,ABERDEEN PROVING GROUND,MD 21010. NR 1 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 11 PY 1991 VL 5 IS 4 BP A828 EP A828 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC207 UT WOS:A1991FC20702658 ER PT J AU DAVIS, VO MYERS, TL LOWENSOHN, HS CALDWELL, RW AF DAVIS, VO MYERS, TL LOWENSOHN, HS CALDWELL, RW TI CARDIOVASCULAR AND PULMONARY EFFECTS OF BETA-ARTEETHER SO FASEB JOURNAL LA English DT Meeting Abstract C1 MED COLL GEORGIA,AUGUSTA,GA 30912. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 11 PY 1991 VL 5 IS 4 BP A493 EP A493 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC207 UT WOS:A1991FC20700708 ER PT J AU DECOSTER, MA HUNTER, JC HUGHES, J TORTELLA, FC AF DECOSTER, MA HUNTER, JC HUGHES, J TORTELLA, FC TI NEUROPROTECTIVE MECHANISMS OF THE NOVEL KAPPA-OPIOID CI-977 SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,MED NEUROSCI RES DEPT,WASHINGTON,DC 20307. PARKE DAVIS RES UNIT,CAMBRIDGE CB2 2QB,ENGLAND. NR 1 TC 3 Z9 3 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 11 PY 1991 VL 5 IS 4 BP A474 EP A474 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC207 UT WOS:A1991FC20700597 ER PT J AU DODD, KT MUNDIE, TG LAGUTCHIK, MS SHARPNACK, DD RIPPLE, GR AF DODD, KT MUNDIE, TG LAGUTCHIK, MS SHARPNACK, DD RIPPLE, GR TI THE EFFECTS OF PULMONARY CONTUSION ON CARDIOPULMONARY FUNCTION IN SHEEP SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,DEPT RESP RES,WASHINGTON,DC 20307. NR 0 TC 2 Z9 2 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 11 PY 1991 VL 5 IS 4 BP A537 EP A537 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC207 UT WOS:A1991FC20700965 ER PT J AU DUBOSE, DA AGNEW, JW AF DUBOSE, DA AGNEW, JW TI EFFECTS OF SEASONAL CHANGE ON BASAL AND EXERCISE LEVELS OF PLASMA FIBRONECTIN (PF) SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 11 PY 1991 VL 5 IS 4 BP A767 EP A767 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC207 UT WOS:A1991FC20702301 ER PT J AU DURKOT, MJ BRYDA, C FRANCESCONI, R DEGARAVILLA, L AF DURKOT, MJ BRYDA, C FRANCESCONI, R DEGARAVILLA, L TI THE EFFECTS OF A SELECTIVE ADENOSINE ANTAGONIST ON CARDIOVASCULAR, THERMOREGULATORY AND EXERCISE PERFORMANCE IN THE HEAT SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. NOVO,PHARMACEUT,BALTIMORE,MD 21224. NR 0 TC 1 Z9 1 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 11 PY 1991 VL 5 IS 4 BP A765 EP A765 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC207 UT WOS:A1991FC20702292 ER PT J AU FRANCESCONI, RP HUBBARD, RW LEVA, NM ANDERSON, BC GOWENLOCK, L AF FRANCESCONI, RP HUBBARD, RW LEVA, NM ANDERSON, BC GOWENLOCK, L TI POTASSIUM (K+) DEFICIENCY - EFFECTS ON INDEXES OF HEAT EXERCISE INJURY AND TISSUE ELECTROLYTE HOMEOSTASIS SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 11 PY 1991 VL 5 IS 4 BP A768 EP A768 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC207 UT WOS:A1991FC20702309 ER PT J AU GAO, YC PEARCE, F WIESMANN, W AF GAO, YC PEARCE, F WIESMANN, W TI ISOLATION OF RAT CORTICAL TUBULAR CELLS - FUNCTIONAL AND METABOLIC ASSESSMENT SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 11 PY 1991 VL 5 IS 4 BP A738 EP A738 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC207 UT WOS:A1991FC20702134 ER PT J AU GENTRY, MK HUR, R BRADY, DR ASHANI, Y DOCTOR, BP AF GENTRY, MK HUR, R BRADY, DR ASHANI, Y DOCTOR, BP TI ISOLATION AND CHARACTERIZATION OF MONOCLONAL-ANTIBODIES WHICH INHIBIT ACETYLCHOLINESTERASES FROM VARIOUS SPECIES AND SOURCES SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. ISRAEL INST BIOL RES,IL-70450 NESS ZIONA,ISRAEL. NR 2 TC 1 Z9 1 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 11 PY 1991 VL 5 IS 4 BP A464 EP A464 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC207 UT WOS:A1991FC20700543 ER PT J AU HEWETSON, JF RIVERA, VR CREASIA, DA LEMLEY, PV RIPPY, MK POLI, MA AF HEWETSON, JF RIVERA, VR CREASIA, DA LEMLEY, PV RIPPY, MK POLI, MA TI PROTECTION OF MICE FROM INHALED RICIN EXPOSURE BY VACCINATION WITH RICIN OR BY PASSIVE TREATMENT WITH HETEROLOGOUS ANTIBODY SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,MED RES INST INFECT DIS,FREDERICK,MD 21701. NR 0 TC 1 Z9 1 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 11 PY 1991 VL 5 IS 4 BP A508 EP A508 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC207 UT WOS:A1991FC20700794 ER PT J AU JOHNSON, JP GRILLO, FG AF JOHNSON, JP GRILLO, FG TI EFFECTS OF BREFELDIN A ON NA+ TRANSPORT IN A-6 CELLS SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 2 Z9 2 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 11 PY 1991 VL 5 IS 4 BP A691 EP A691 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC207 UT WOS:A1991FC20701862 ER PT J AU KRAKAUER, T KRAKAUER, H AF KRAKAUER, T KRAKAUER, H TI A METHOD FOR THE QUANTITATIVE-ANALYSIS AND STANDARDIZATION OF INTERLEUKIN-1 BIOACTIVITY SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,MED RES INST INFECT DIS,FREDERICA,MD 21702. HLTH CARE FINANCING ADM,BALTIMORE,MD 21207. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 11 PY 1991 VL 5 IS 4 BP A623 EP A623 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC207 UT WOS:A1991FC20701464 ER PT J AU LAGUTCHIK, MS MUNDIE, TG DODD, KT MARTIN, DG AF LAGUTCHIK, MS MUNDIE, TG DODD, KT MARTIN, DG TI PRIOR ISOFLURANE ANESTHESIA DOES NOT ALTER MAXIMAL OXYGEN-CONSUMPTION IN SHEEP SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 1 Z9 1 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 11 PY 1991 VL 5 IS 4 BP A764 EP A764 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC207 UT WOS:A1991FC20702284 ER PT J AU MARTENS, ME AF MARTENS, ME TI GLUCOSE-METABOLISM AND NAD+ CONTENT IN CULTURED HUMAN EPIDERMAL-KERATINOCYTES EXPOSED TO SULFUR MUSTARD (HD) SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,MED RES INST INFECT DIS,BIOCHEM PHARMACOL BRANCH,FREDERICK,MD 21701. NR 0 TC 4 Z9 4 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 11 PY 1991 VL 5 IS 4 BP A823 EP A823 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC207 UT WOS:A1991FC20702629 ER PT J AU MCNEIL, J MUNDIE, T RIPPLE, G JACKSON, B MARTIN, D AF MCNEIL, J MUNDIE, T RIPPLE, G JACKSON, B MARTIN, D TI ERRORS OF UTILIZING CARBON-MONOXIDE UPTAKE TO DETERMINE RED-CELL MASS SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,DEPT RESP RES,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 11 PY 1991 VL 5 IS 4 BP A686 EP A686 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC207 UT WOS:A1991FC20701836 ER PT J AU MEIER, HL AF MEIER, HL TI THE KINETICS OF 2,2'-DICHLORODIETHYL SULFIDE (SULFUR MUSTARD, HD) DEPENDENT CELL-DEATH SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,CHEM DEF RES INST,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 11 PY 1991 VL 5 IS 4 BP A553 EP A553 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC207 UT WOS:A1991FC20701062 ER PT J AU MORETON, JE ROBLES, L MILLER, K SPREGHN, H TAYLOR, JP TORTELLA, FC AF MORETON, JE ROBLES, L MILLER, K SPREGHN, H TAYLOR, JP TORTELLA, FC TI EFFECTS OF THE SELECTIVE KAPPA OPIOID AGONIST PD117302 ON EEG, NEUROLOGIC AND BEHAVIORAL RECOVERY AFTER 4-VESSEL CEREBRAL-ISCHEMIA IN THE UNANESTHETIZED RAT SO FASEB JOURNAL LA English DT Meeting Abstract C1 UNIV MARYLAND,SCH PHARM,BALTIMORE,MD 21201. WALTER REED ARMY MED CTR,DIV NEUROPSYCHIAT,NEUROPHARMACOL BRANCH,WASHINGTON,DC 20307. NR 0 TC 2 Z9 2 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 11 PY 1991 VL 5 IS 4 BP A862 EP A862 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC207 UT WOS:A1991FC20702859 ER PT J AU PANDOLF, KB GANGE, RW LATZKA, WA BLANK, IH YOUNG, AJ SAWKA, MN AF PANDOLF, KB GANGE, RW LATZKA, WA BLANK, IH YOUNG, AJ SAWKA, MN TI HUMAN THERMOREGULATORY RESPONSES DURING COLD-WATER IMMERSION AFTER ARTIFICIALLY-INDUCED SUNBURN SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,INST ENVIRONM MED,NATICK,MA 01760. MASSACHUSETTS GEN HOSP,WELLMAN LABS PHOTOMED,BOSTON,MA 02114. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 11 PY 1991 VL 5 IS 4 BP A393 EP A393 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC207 UT WOS:A1991FC20700133 ER PT J AU QIAN, C LIU, CT PETERS, CJ AF QIAN, C LIU, CT PETERS, CJ TI INCREASE OF PLATELET-ACTIVATING-FACTOR (PAF) IN HEART AND LUNG OF PICHINDE VIRUS-INFECTED GUINEA-PIGS SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,MED RES INST INFECT DIS,FT DETRICK,MD 21702. NR 2 TC 1 Z9 1 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 11 PY 1991 VL 5 IS 4 BP A895 EP A895 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC207 UT WOS:A1991FC20703050 ER PT J AU SAXENA, A ASHANI, Y BRADY, DR GENTRY, MK HUR, RS HIVELY, H LARRISON, R DOCTOR, BP AF SAXENA, A ASHANI, Y BRADY, DR GENTRY, MK HUR, RS HIVELY, H LARRISON, R DOCTOR, BP TI ISOLATION AND PARTIAL CHARACTERIZATION OF AN ACTIVE STABLE MONOMERIC FORM OF FETAL BOVINE SERUM ACETYLCHOLINESTERASE SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 1 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 11 PY 1991 VL 5 IS 4 BP A430 EP A430 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC207 UT WOS:A1991FC20700343 ER PT J AU SEIKEN, GL SCHAUDIES, RP AF SEIKEN, GL SCHAUDIES, RP TI TISSUE-LEVELS OF EGF IN ACUTE-RENAL-FAILURE IN RATS SO FASEB JOURNAL LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,DEPT NEPHROL,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 11 PY 1991 VL 5 IS 4 BP A909 EP A909 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC207 UT WOS:A1991FC20703131 ER PT J AU SMITH, WJ COWAN, FM BROOMFIELD, CA AF SMITH, WJ COWAN, FM BROOMFIELD, CA TI INCREASED PROTEOLYTIC ACTIVITY IN HUMAN EPITHELIAL-CELLS FOLLOWING EXPOSURE TO SULFUR MUSTARD SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,ABERDEEN PROVING GROUND,MD 21010. NR 0 TC 16 Z9 16 U1 0 U2 1 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 11 PY 1991 VL 5 IS 4 BP A828 EP A828 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC207 UT WOS:A1991FC20702656 ER PT J AU TAYLOR, TJ PARKER, GW KHOSLA, RC SAVIOLAKIS, GA AF TAYLOR, TJ PARKER, GW KHOSLA, RC SAVIOLAKIS, GA TI PLASMA ENDOTHELIN LEVELS DURING ACUTE HEMODYNAMIC-CHANGES INDUCED BY PALYTOXIN AND ENDOTOXIN SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,MED RES INST INFECT DIS,FREDERICK,MD 21702. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 11 PY 1991 VL 5 IS 4 BP A399 EP A399 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC207 UT WOS:A1991FC20700165 ER PT J AU UYEHARA, CFT SIM, HH EICHINGER, MR CLAYBAUGH, JR AF UYEHARA, CFT SIM, HH EICHINGER, MR CLAYBAUGH, JR TI VASOPRESSIN, RENIN, ALDOSTERONE, AND PULMONARY HEMODYNAMIC-RESPONSES TO ACUTE EUCAPNIC HYPOXIA IN NEWBORN PIGLETS SO FASEB JOURNAL LA English DT Meeting Abstract C1 TRIPLER ARMY MED CTR,HONOLULU,HI 96859. KAPIOLANI MED CTR,HONOLULU,HI. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 11 PY 1991 VL 5 IS 4 BP A374 EP A374 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC207 UT WOS:A1991FC20700018 ER PT J AU WALLUM, TE LIU, CT PETERS, CJ AF WALLUM, TE LIU, CT PETERS, CJ TI INHIBITION OF NA+/K+-ATPASE ACTIVITY IN KIDNEYS OF PICHINDE VIRUS-INFECTED STRAIN-13 GUINEA-PIGS SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,MED RES INST INFECT DIS,FREDERICK,MD 21701. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 11 PY 1991 VL 5 IS 4 BP A908 EP A908 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC207 UT WOS:A1991FC20703126 ER PT J AU WANNEMACHER, RW THOMPSON, WL DINTERMAN, RE AF WANNEMACHER, RW THOMPSON, WL DINTERMAN, RE TI USE OF LACTULOSE FOR PROPHYLAXIS TREATMENT OF RICIN (RCA60) INTOXICATION SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,MED RES INST INFECT DIS,FREDERICK,MD 21701. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 11 PY 1991 VL 5 IS 4 BP A822 EP A822 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC207 UT WOS:A1991FC20702624 ER PT J AU WELLNER, RB PATTON, LL HOLMES, MJ LEWIS, RL AF WELLNER, RB PATTON, LL HOLMES, MJ LEWIS, RL TI MAITOTOXIN (MTX) STIMULATES K+ TRANSPORT IN A HUMAN SALIVARY EPITHELIAL-CELL LINE (HSG-PA) SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,MED RES INST INFECT DIS,FREDERICK,MD 21701. UNIV N CAROLINA,CHAPEL HILL,NC 27599. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 11 PY 1991 VL 5 IS 4 BP A821 EP A821 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC207 UT WOS:A1991FC20702617 ER PT J AU YOUNG, AJ SAWKA, MN BURGOON, PW LEVINE, L QUIGLEY, MD LATZKA, WA PANDOLF, KB AF YOUNG, AJ SAWKA, MN BURGOON, PW LEVINE, L QUIGLEY, MD LATZKA, WA PANDOLF, KB TI THE ROLE OF THERMAL FACTORS IN TRAINING-INDUCED ADAPTATIONS OF METABOLIC RESPONSES TO EXERCISE SO FASEB JOURNAL LA English DT Meeting Abstract C1 USA,ENVIRONM MED RES INST,NATICK,MA 01760. NR 0 TC 0 Z9 0 U1 0 U2 0 PU FEDERATION AMER SOC EXP BIOL PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 SN 0892-6638 J9 FASEB J JI Faseb J. PD MAR 11 PY 1991 VL 5 IS 4 BP A661 EP A661 PN 1 PG 1 WC Biochemistry & Molecular Biology; Biology; Cell Biology SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology GA FC207 UT WOS:A1991FC20701688 ER PT J AU KLEMER, A BARKO, J AF KLEMER, A BARKO, J TI EFFECTS OF MIXING AND SILICA ENRICHMENT ON PHYTOPLANKTON SEASONAL SUCCESSION SO HYDROBIOLOGIA LA English DT Article DE PHYTOPLANKTON; SUCCESSION; MIXING; SILICA; ENRICHMENT; NUTRIENTS; NITROGEN; PHOSPHORUS; CARBON; CARBON DIOXIDE; BICARBONATE; LIGHT; TRANSPARENCY; CRYPTOPHYTES; DIATOMS; BLUE GREEN ALGAE; CYANOPHYTES; DINOFLAGELLATES; GREENS; DOMINANCE ID BLUE-GREEN-ALGAE; GROWTH-RATE; WATER; POPULATION; DYNAMICS; NITROGEN; CARBON; LAKES AB During the summer of 1983, cryptophytes, diatoms, cyanophytes, and the dinoflagellate, Ceratium hirundinella were most prominant among the phytoplankton of Eau Galle Reservoir. In the open water, cryptophytes and diatoms peaked in the spring, cyanophytes were most successful in the early summer, and Ceratium was dominant from mid-July until early August. In general, the sequence of events corresponded quite closely to the model of seasonal succession developed by the Plankton Ecology Group of the International Society of Limnology. To a large extent, the same pattern held in four experimental water columns. Departures from the model involved the roles of specific nutrients in diatom and cyanophyte periodicity. Diatoms began to yield to cyanophytes in late spring despite intermittent mixing and silica enrichment. Although capable of buoyancy regulation and thus well adapted to stable water columns, cyanophytes had greater increases in biomass in mixed columns, and in those columns, were most successful during a period of intermittent mixing. Cyanophyte success varied inversely with TN:TP ratios during the period of intermittent mixing, but not subsequently. By mid-July, Ceratium dominated the phytoplankton of every column except that of a mixed column in which conditions favored cyanophytes and large diatom species. C1 WATERWAYS EXPT STN,ENVIRONM LAB,VICKSBURG,MS 39180. RP KLEMER, A (reprint author), UNIV MINNESOTA,DEPT BIOL,DULUTH,MN 55812, USA. NR 36 TC 9 Z9 10 U1 3 U2 10 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 0018-8158 J9 HYDROBIOLOGIA JI Hydrobiologia PD MAR 8 PY 1991 VL 210 IS 3 BP 171 EP 181 DI 10.1007/BF00034675 PG 11 WC Marine & Freshwater Biology SC Marine & Freshwater Biology GA FF637 UT WOS:A1991FF63700002 ER PT J AU ASHLEY, PR TUMOLILLO, TA AF ASHLEY, PR TUMOLILLO, TA TI CHANNEL WAVE-GUIDES IN ELECTROOPTIC POLYMERS USING A PHOTOPOLYMER CLADDING TECHNIQUE SO APPLIED PHYSICS LETTERS LA English DT Article AB Reported here is a new fabrication technique for forming channel waveguides in organic electro-optic (EO) polymer materials. The process uses projection printing to directly expose inverted ridge channel patterns in a UV curing optical epoxy cladding layer. This technique is noncontact, requires no post processing, minimizes wall roughness, and can be used with any spin coatable EO polymer. Single-mode channel waveguides have been demonstrated and characterized as well as phase modulator devices. C1 UNIV ALABAMA,DEPT PHYS,HUNTSVILLE,AL 35899. RP ASHLEY, PR (reprint author), USA,MISSILE COMMAND,CTR RES DEV & ENGN,WEAPONS SCI DIRECTORATE,REDSTONE ARSENAL,AL 35898, USA. NR 11 TC 12 Z9 14 U1 0 U2 3 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD MAR 4 PY 1991 VL 58 IS 9 BP 884 EP 886 DI 10.1063/1.105210 PG 3 WC Physics, Applied SC Physics GA FA938 UT WOS:A1991FA93800003 ER PT J AU JALALIHERAVI, M MCMANUS, SP ZUTAUT, SE MCDONALD, JK AF JALALIHERAVI, M MCMANUS, SP ZUTAUT, SE MCDONALD, JK TI A THEORETICAL INVESTIGATION OF THE ELECTRONIC-PROPERTIES AND STRUCTURE OF SOME MODEL POLY(DIACETYLENES) SO MACROMOLECULES LA English DT Article ID NONLINEAR OPTICAL-PROPERTIES; POLYDIACETYLENE; POLYMERS; PARAMETERS; TRANSITION; MOLECULES AB The electronic properties of some model poly(diacetylenes) were investigated by using AM1 and, to a limited extent, MNDO and PM3 semiempirical SCF-MO methods. The capped-bond option allowed for simulation of polymer structures but the option has limitations when computing electronic properties of conjugated polymers. With optimized geometries, AM1-computed structures for poly(diacetylene) models favor the enyne structure. The chemical and electronic effects of substituents on the structure of the polymer backbone were investigated, and the Koopman ionization potential and bandgap were computed and discussed. The changes in HOMO and LUMO energies as a function of nonplanarity along the backbone were also calculated. The bandgaps of some diacetylene monomers and several oligomers were computed for comparison with experimental values of diacetylene monomers and polymers. Finally, some AM1 calculations are included showing variations in geometry, atomic charge, and bandgap with chain length in a series of oligomeric diacetylenes. C1 UNIV ALABAMA,DEPT CHEM,HUNTSVILLE,AL 35899. USA,MISSILE COMMAND,CTR RES DEV & ENGN,RES DIRECTORATE,REDSTONE ARSENAL,AL 35898. NR 32 TC 7 Z9 7 U1 0 U2 3 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0024-9297 J9 MACROMOLECULES JI Macromolecules PD MAR 4 PY 1991 VL 24 IS 5 BP 1055 EP 1063 DI 10.1021/ma00005a013 PG 9 WC Polymer Science SC Polymer Science GA FA473 UT WOS:A1991FA47300013 ER PT J AU FRIEDL, KE VOGEL, JA AF FRIEDL, KE VOGEL, JA TI LOOKING FOR A FEW GOOD GENERALIZED BODY-FAT EQUATIONS SO AMERICAN JOURNAL OF CLINICAL NUTRITION LA English DT Letter ID DUAL-PHOTON ABSORPTIOMETRY; DENSITY; MASS; MEN RP FRIEDL, KE (reprint author), USA,RIEM,DIV EXERCISE PHYSIOL,NATICK,MA 01760, USA. OI Friedl, Karl/0000-0002-3134-8427 NR 12 TC 3 Z9 3 U1 0 U2 0 PU AMER SOC CLIN NUTRITION INC PI BETHESDA PA 9650 ROCKVILLE PIKE SUBSCRIPTIONS, RM L-2310, BETHESDA, MD 20814-3998 SN 0002-9165 J9 AM J CLIN NUTR JI Am. J. Clin. Nutr. PD MAR PY 1991 VL 53 IS 3 BP 795 EP 796 PG 2 WC Nutrition & Dietetics SC Nutrition & Dietetics GA FA644 UT WOS:A1991FA64400037 PM 2000836 ER PT J AU GENDRON, BP AF GENDRON, BP TI LOXOSCELES ENVENOMATION - REPLY SO AMERICAN JOURNAL OF EMERGENCY MEDICINE LA English DT Letter RP GENDRON, BP (reprint author), USA,MADIGAN MED CTR,TACOMA,WA, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0735-6757 J9 AM J EMERG MED JI Am. J. Emerg. Med. PD MAR PY 1991 VL 9 IS 2 BP 203 EP 203 DI 10.1016/0735-6757(91)90195-P PG 1 WC Emergency Medicine SC Emergency Medicine GA EZ760 UT WOS:A1991EZ76000027 ER PT J AU DIBISCEGLIE, AM ORDER, SE KLEIN, JL WAGGONER, JG SJOGREN, MH KUO, G HOUGHTON, M CHOO, QL HOOFNAGLE, JH AF DIBISCEGLIE, AM ORDER, SE KLEIN, JL WAGGONER, JG SJOGREN, MH KUO, G HOUGHTON, M CHOO, QL HOOFNAGLE, JH TI THE ROLE OF CHRONIC VIRAL-HEPATITIS IN HEPATOCELLULAR-CARCINOMA IN THE UNITED-STATES SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Article ID NON-B-HEPATITIS; NON-A; AMERICAN PATIENTS; VIRUS; LIVER; ANTIGEN; ASSOCIATION; TRANSFUSION; INFECTION; FEATURES AB Although hepatocellular carcinoma is a relatively uncommon tumor in the United States, it is quite common in sub-Saharan Africa and the Far East, where most cases are associated with infection with the hepatitis B virus. We have studied 99 American patients with hepatocellular carcinoma for evidence of hepatitis B or hepatitis C viral infection and compared these findings to those in a group of matched controls with other cancers. The two groups differed in proportion, with hepatitis B surface antigen in serum being significantly higher in patients with hepatocellular carcinoma (7% vs. 0%, p = 0.009). Antibody to hepatitis C virus was also found more frequently in patients with hepatocellular carcinoma (13% vs. 2%, p = 0.002). The relative risk for hepatocellular carcinoma in hepatitis B surface antigen-positive patients was calculated to be 17.3 and for antibody to hepatitis C virus to be 7.3. The attributable fraction of cases related to the hepatitis B surface antigen carrier state was 6.7% and for patients infected with the hepatitis C virus was 11.4%. Approximately three quarters of cases of hepatocellular carcinoma did not have evidence of either hepatitis C or hepatitis B virus infection. These findings provide strong evidence that hepatitis C virus infection is associated with the development of hepatocellular carcinoma, and in the United States may even play a more important role than the hepatitis B virus. C1 JOHNS HOPKINS UNIV HOSP,DEPT RADIAT ONCOL,BALTIMORE,MD 21205. WALTER REED ARMY MED CTR,VIRUS DIS SECT,WASHINGTON,DC 20307. CHIRON CORP,EMERYVILLE,CA. RP DIBISCEGLIE, AM (reprint author), NIADDKD,LIVER DIS SECT,DIGEST DIS BRANCH,BLDG 10,ROOM 4D 52,BETHESDA,MD 20892, USA. NR 22 TC 123 Z9 123 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD MAR PY 1991 VL 86 IS 3 BP 335 EP 338 PG 4 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA FB763 UT WOS:A1991FB76300018 PM 1847790 ER PT J AU TURNER, GH LOBNER, T PATRICK, J AF TURNER, GH LOBNER, T PATRICK, J TI PHARMACEUTICAL SERVICES REQUIRED DURING SETUP OF AN ARMY COMBAT SUPPORT HOSPITAL SO AMERICAN JOURNAL OF HOSPITAL PHARMACY LA English DT Article RP TURNER, GH (reprint author), USA,47TH COMBAT SUPPORT HOSP,OPERAT DESERT STORM,APO,NEW YORK,NY 09657, USA. NR 0 TC 4 Z9 4 U1 0 U2 0 PU AMER SOC HEALTH-SYSTEM PHARMACISTS PI BETHESDA PA 7272 WISCONSIN AVE, BETHESDA, MD 20814 SN 0002-9289 J9 AM J HOSP PHARM JI Am. J. Hosp. Pharm. PD MAR PY 1991 VL 48 IS 3 BP 533 EP 535 PG 3 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA EZ524 UT WOS:A1991EZ52400027 PM 2029003 ER PT J AU MURPHY, TP AF MURPHY, TP TI MACROVASCULAR SENSORINEURAL HEARING-LOSS SO AMERICAN JOURNAL OF OTOLOGY LA English DT Article ID DURAL ARTERIOVENOUS-MALFORMATIONS; VASCULAR LOOP; COMPRESSION; ANEURYSM; NERVE AB Sensorineural hearing loss (SNHL) has many etiologies including vascular sources. Vascular causes of SNHL can occur at the microvascular level. Macrovascular level may be described as arising from vessels proximal to the labyrinthine artery or those vessels that can be visualized without the aid of a microscope. Otologic symptomatology and diagnostic evaluation of the SNHL may reveal a macroscopic vascular source. Representative cases of macrovascular sensorineural hearing loss due to aneurysm, arteriovenous malformation, and vertebrosbasilar artery dolichoectasia are presented. C1 BROOKE ARMY MED CTR,DEPT OTOLARYNGOL,FT SAM HOUSTON,TX 78234. NR 22 TC 8 Z9 10 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0192-9763 J9 AM J OTOL JI Am. J. Otol. PD MAR PY 1991 VL 12 IS 2 BP 88 EP 92 PG 5 WC Otorhinolaryngology SC Otorhinolaryngology GA FD796 UT WOS:A1991FD79600003 PM 2053611 ER PT J AU GERSCH, HA AF GERSCH, HA TI CUMULANT EXPANSIONS IN STATISTICAL AND QUANTUM PHYSICS SO AMERICAN JOURNAL OF PHYSICS LA English DT Article AB Two examples are given of the use of cumulant expansions for systems of particles with hard-core two-body interactions. One of these, in classical statistical mechanics, is shown to lead to virial coefficients. An analogous procedure in quantum mechanics produces energy level shifts due to hard-core interactions that are expressed in terms of the t matrix. C1 US MIL ACAD,DEPT PHYS,W POINT,NY 10996. NR 5 TC 0 Z9 0 U1 0 U2 1 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0002-9505 J9 AM J PHYS JI Am. J. Phys. PD MAR PY 1991 VL 59 IS 3 BP 273 EP 277 DI 10.1119/1.16576 PG 5 WC Education, Scientific Disciplines; Physics, Multidisciplinary SC Education & Educational Research; Physics GA EZ353 UT WOS:A1991EZ35300019 ER PT J AU TURELL, MJ ROSSI, CA AF TURELL, MJ ROSSI, CA TI POTENTIAL FOR MOSQUITO TRANSMISSION OF ATTENUATED STRAINS OF RIFT-VALLEY FEVER VIRUS SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID CULEX-PIPIENS; VECTOR; EGYPT AB Studies were conducted to determine if two attenuated strains of Rift Valley fever (RVF) virus could be transmitted by Culex pipiens mosquitoes. Both strains (RVF MP 12 and T1) replicated in and were transmitted by female Cx. pipiens after intrathoracic inoculation. Mosquitoes also became infected with and transmitted the RVF MP 12 strain after ingesting virus from a blood-soaked cotton pledget. However, because of the low viremias produced in infected animals, it is unlikely that mosquitoes would become infected by feeding on an animal inoculated with either of these viruses. Although both strains were transmitted by mosquitoes after intrathoracic inoculation, there was no evidence of reversion to a virulent virus. RP TURELL, MJ (reprint author), USA,MED RES INST INFECT DIS,FREDERICK,MD 21702, USA. NR 15 TC 11 Z9 11 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD MAR PY 1991 VL 44 IS 3 BP 278 EP 282 PG 5 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA FN791 UT WOS:A1991FN79100006 PM 2035749 ER PT J AU DEMCHAK, CC AF DEMCHAK, CC TI ARMED SERVICES AND SOCIETY - EDMONDS,M SO AMERICAN POLITICAL SCIENCE REVIEW LA English DT Book Review RP DEMCHAK, CC (reprint author), US MIL ACAD,W POINT,NY 10996, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU AMER POLITICAL SCI ASSN PI WASHINGTON PA 1527 NEW HAMPSHIRE N W, WASHINGTON, DC 20036 SN 0003-0554 J9 AM POLIT SCI REV JI Am. Polit. Sci. Rev. PD MAR PY 1991 VL 85 IS 1 BP 282 EP 284 DI 10.2307/1962914 PG 3 WC Political Science SC Government & Law GA FE995 UT WOS:A1991FE99500051 ER PT J AU SNAPPER, JR BUTTERFIELD, MJ RAYBURN, DB LEFFERTS, PL AF SNAPPER, JR BUTTERFIELD, MJ RAYBURN, DB LEFFERTS, PL TI EFFECTS OF REPETITIVE BOLUS INJECTIONS OF ZYMOSAN-ACTIVATED PLASMA ON LUNG-MECHANICS AND AIRWAY RESPONSIVENESS IN AWAKE SHEEP SO AMERICAN REVIEW OF RESPIRATORY DISEASE LA English DT Article ID PHORBOL-MYRISTATE ACETATE; AEROSOL HISTAMINE; INJURY; ENDOTOXIN; MEDIATORS AB We studied the pulmonary effects of repetitive bolus injections of autologous zymosan-activated plasma (ZAP) in nine chronically instrumented awake sheep. Aerosol histamine responsiveness was determined 1 h before and 4.5 h after the first bolus injection of ZAP. Each sheep received in the pulmonary artery a total of eight 5-ml bolus injections of ZAP separated by 30 min. On a separate day, with the order of experimentation varied to avoid sequential bias, six of the nine sheep also received "control" plasma (plasma prepared in the identical fashion as ZAP but not incubated with zymosan). "Control" plasma caused reproducible transient increases in pulmonary artery pressure, but it did not cause alterations in any of the other measured variables. Repetitive bolus injections of ZAP caused reproducible alterations in lung mechanics, pulmonary hemodynamics, lung fluid and solute exchange, oxygenation, and peripheral leukocyte counts. The increases in thromboxane-B2 concentrations in lung lymph and plasma were greatest after the first bolus injection of ZAP, with the magnitude of these changes diminishing on succeeding injections of ZAP. Aerosol histamine responsiveness did not increase after the eight bolus injections of ZAP. C1 VANDERBILT UNIV,MED CTR,SCH MED,DEPT MED,CTR LUNG RES,NASHVILLE,TN 37232. WALTER REED ARMY MED CTR,DEPT RESP RES,WASHINGTON,DC 20307. FU NHLBI NIH HHS [HL-19153, HL-27274] NR 26 TC 2 Z9 2 U1 0 U2 0 PU AMER LUNG ASSOC PI NEW YORK PA 1740 BROADWAY, NEW YORK, NY 10019 SN 0003-0805 J9 AM REV RESPIR DIS JI Am. Rev. Respir. Dis. PD MAR PY 1991 VL 143 IS 3 BP 578 EP 584 PG 7 WC Respiratory System SC Respiratory System GA FA931 UT WOS:A1991FA93100022 PM 2001069 ER PT J AU SNYDER, AP SHOFF, DB EICEMAN, GA BLYTH, DA PARSONS, JA AF SNYDER, AP SHOFF, DB EICEMAN, GA BLYTH, DA PARSONS, JA TI DETECTION OF BACTERIA BY ION MOBILITY SPECTROMETRY SO ANALYTICAL CHEMISTRY LA English DT Note ID FECAL COLIFORMS; WATER; ENUMERATION; IDENTIFICATION; ASSAY C1 NEW MEXICO STATE UNIV,DEPT CHEM,LAS CRUCES,NM 88003. GEOCENTERS INC,FT WASHINGTON,MD 20744. RP SNYDER, AP (reprint author), USA,CTR DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010, USA. NR 34 TC 31 Z9 33 U1 1 U2 10 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0003-2700 J9 ANAL CHEM JI Anal. Chem. PD MAR 1 PY 1991 VL 63 IS 5 BP 526 EP 529 DI 10.1021/ac00005a028 PG 4 WC Chemistry, Analytical SC Chemistry GA FA188 UT WOS:A1991FA18800030 PM 2064011 ER PT J AU KRAMER, KK THOMASSEN, T EVAUL, J AF KRAMER, KK THOMASSEN, T EVAUL, J TI INTRAOCULAR IRRIGATING SOLUTIONS - A CLINICAL-STUDY OF BSS PLUS AND DEXTROSE BICARBONATE LACTATED RINGERS SOLUTION SO ANNALS OF OPHTHALMOLOGY LA English DT Article ID CORNEAL ENDOTHELIUM; PHACOEMULSIFICATION AB Intraocular irrigating solutions of varying compositions and costs are available for cataract surgery. We studied preoperative and two months postoperative extracapsular cataract extraction and intraocular lens implant corneal endothelial cell size in two groups. One group had received an intraoperative irrigating solution of lactated Ringer's with dextrose and bicarbonate. The other irrigating solution was BSS Plus which differs chiefly in the presence of glutathione. A nonstatistically significant trend in favor of BSS Plus was observed. C1 UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. RP KRAMER, KK (reprint author), WALTER REED ARMY MED CTR,DEPT CLIN INVEST,OPHTHALMOL SERV,HSHL-SI,ROOM 1F15,WASHINGTON,DC 20307, USA. NR 18 TC 7 Z9 8 U1 0 U2 0 PU AMER SOC CONTEMPORARY OPHTHALMOLOGY PI SKOKIE PA 4711 GOLF RD, SUITE 408, SKOKIE, IL 60076-1242 SN 0003-4886 J9 ANN OPHTHALMOL JI Ann. Ophthalmol. PD MAR PY 1991 VL 23 IS 3 BP 101 EP 105 PG 5 WC Ophthalmology SC Ophthalmology GA FD010 UT WOS:A1991FD01000004 PM 2039173 ER PT J AU BREGMAN, DK HODGES, T LAPIANA, FG AF BREGMAN, DK HODGES, T LAPIANA, FG TI ANTIGRANULOCYTES CELL TUMOR OF THE EYELID SO ANNALS OF OPHTHALMOLOGY LA English DT Article AB We present a case of granular cell tumor of the eyelid. Although commonly reported elsewhere in the body, this entity rarely occurs in the ocular adnexa. C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. NR 3 TC 3 Z9 3 U1 0 U2 0 PU AMER SOC CONTEMPORARY OPHTHALMOLOGY PI SKOKIE PA 4711 GOLF RD, SUITE 408, SKOKIE, IL 60076-1242 SN 0003-4886 J9 ANN OPHTHALMOL JI Ann. Ophthalmol. PD MAR PY 1991 VL 23 IS 3 BP 106 EP 107 PG 2 WC Ophthalmology SC Ophthalmology GA FD010 UT WOS:A1991FD01000005 PM 1645506 ER PT J AU COHEN, AJ THOMPSON, L EDWARDS, FH BELLAMY, RF AF COHEN, AJ THOMPSON, L EDWARDS, FH BELLAMY, RF TI PRIMARY CYSTS AND TUMORS OF THE MEDIASTINUM SO ANNALS OF THORACIC SURGERY LA English DT Article ID MEDIAN STERNOTOMY; MASSES; MANAGEMENT; RESECTION AB A retrospective analysis was performed on 230 patients with primary cysts and tumors of the mediastinum seen at our institution from January 1944 to April 1989. We divided these patients into two groups. Group 1 was seen before 1970 and group 2 was seen from January 1970 to April 1989. There was a significant increase in the prevalence of malignancy in group 2 (47.2% versus 17.1%; p < 0.0001) due to an increase in the number of lymphomas (22.6% versus 3.5%; p < 0.001) and malignant neurogenic tumors (6.8% versus 1.1%; p = 0.0528). There was a significant increase in the number of malignant tumors in the anterior (59.5% versus 30.9%; p = 0.0022) and paravertebral (28.5% versus 2.8%; p = 0.0027) compartments in group 2. More patients with these tumors were symptomatic in group 2 (63.6% versus 5%; p = 0.0422). There was an increase of ancillary diagnostic studies performed to evaluate these tumors (76.0% versus 34.5%; p = 0.0422). Logistic regression analysis identified date of presentation (p < 0.005), symptoms (p < 0.01), size (p < 0.005), and the anterior mediastinal compartment (p < 0.005) as preoperative predictors of malignancy. The surgical approach to these tumors included more median sternotomy (30.1% versus 10.7%; p = 0.0008), anterior mediastinotomy, and cervical mediastinoscopy in group 2 (1.1% versus 17.5%; p = 0.0002). Long-term results support surgical resection in benign lesions and an aggressive multimodality approach to malignant lesions. C1 WALTER REED ARMY MED CTR,DEPT THORAC SURG,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,DEPT SURG,BETHESDA,MD 20814. NR 21 TC 55 Z9 59 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0003-4975 J9 ANN THORAC SURG JI Ann. Thorac. Surg. PD MAR PY 1991 VL 51 IS 3 BP 378 EP 386 PG 9 WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery SC Cardiovascular System & Cardiology; Respiratory System; Surgery GA FB017 UT WOS:A1991FB01700005 PM 1998414 ER PT J AU MEADE, P MOAD, J FELLOWS, D ADAMS, CW AF MEADE, P MOAD, J FELLOWS, D ADAMS, CW TI CARCINOSARCOMA OF THE LUNG WITH HYPERTROPHIC PULMONARY OSTEOARTHROPATHY SO ANNALS OF THORACIC SURGERY LA English DT Article AB Carcinosarcoma of the lung is a rare malignancy. Endobronchial and parenchymal variant are classically described. Clinicopathological features are often related to anatomical location, as is the case for most lung neoplasms. This case report details the surgical management of a carcinosarcoma in a patient seen with pulmonary osteoarthropathy. C1 TRIPLER ARMY MED CTR,DEPT ANAT PATHOL,HONOLULU,HI 96859. TRIPLER ARMY MED CTR,DEPT CARDIOTHORAC SURG,HONOLULU,HI 96859. TRIPLER ARMY MED CTR,DEPT RADIOL,HONOLULU,HI 96859. RP MEADE, P (reprint author), TRIPLER ARMY MED CTR,DEPT SURG,GEN SURG SERV,HONOLULU,HI 96859, USA. NR 9 TC 13 Z9 14 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0003-4975 J9 ANN THORAC SURG JI Ann. Thorac. Surg. PD MAR PY 1991 VL 51 IS 3 BP 488 EP 490 PG 3 WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery SC Cardiovascular System & Cardiology; Respiratory System; Surgery GA FB017 UT WOS:A1991FB01700028 PM 1998434 ER PT J AU SMEE, DF HUFFMAN, JH GESSAMAN, AC HUGGINS, JW SIDWELL, RW AF SMEE, DF HUFFMAN, JH GESSAMAN, AC HUGGINS, JW SIDWELL, RW TI PROPHYLACTIC AND THERAPEUTIC ACTIVITIES OF 7-THIA-8-OXOGUANOSINE AGAINST PUNTA-TORO VIRUS-INFECTIONS IN MICE SO ANTIVIRAL RESEARCH LA English DT Article DE PHLEBOVIRUS; NUCLEOSIDE; INTERFERON INDUCER ID INTERFERON-INDUCING PROPERTIES; SEMLIKI FOREST VIRUS; ENCEPHALOMYOCARDITIS VIRUS; ANTIVIRAL ACTIVITY; INDUCTION; RIBAVIRIN; INDUCERS; INVITRO AB The biological response modifier 7-thia-8-oxoguanosine was evaluated in mice against the hepatotropic Adames strain of Punta Toro virus. When administered intraperitoneally in divided doses, significant protection from death was conferred at doses of 50 and 100 mg/kg/day given 24 and 17 h pre-virus inoculation, 25-100 mg/kg/day administered 4 h pre- and 3 h post-virus challenge, and 12.5 to 100 mg/kg/day administered 24 and 31 h after virus inoculation. These doses preventing death reduced liver icterus scores, serum alanine aminotransferase and aspartate aminotransferase levels, and liver and serum virus titers relative to placebo controls. Full daily doses administered at 24 h were somewhat less protective to mice than divided daily doses starting at the same time. The initiation of treatment could be delayed as late as 36 h after virus inoculation, resulting in complete protection from mortality at 100 mg/kg/day. This prevention of death occurred despite the acute nature of the infection which resulted in deaths by 96 h in the placebo-treated controls. These results show that 7-thia-8-oxoguanosine has both prophylactic and therapeutic potential as an anti-Phlebovirus agent. Interferon induction appears to be the reason for antiviral activity in this model, since up to 10000 units of interferon/ml were induced in mice 1 h after treatment with 100 mg 7-thia-8-oxo-guanosine per kg, and antibody to interferon-alpha/beta administered shortly after treatment with the nucleoside negated the antiviral effect. C1 USA,MED RES INST INFECT DIS,DIV VIROL,FT DETRICK,MD. RP SMEE, DF (reprint author), UTAH STATE UNIV,DEPT ANIM DAIRY & VET SCI,ANTIVIRAL PROGRAM,LOGAN,UT 84322, USA. NR 20 TC 27 Z9 27 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-3542 J9 ANTIVIR RES JI Antiviral Res. PD MAR-APR PY 1991 VL 15 IS 3 BP 229 EP 239 DI 10.1016/0166-3542(91)90069-4 PG 11 WC Pharmacology & Pharmacy; Virology SC Pharmacology & Pharmacy; Virology GA FN038 UT WOS:A1991FN03800006 PM 1716090 ER PT J AU PESCERODRIGUEZ, RA FIFER, RA AF PESCERODRIGUEZ, RA FIFER, RA TI APPLICATIONS OF FOURIER-TRANSFORM INFRARED PHOTOACOUSTIC-SPECTROSCOPY TO SOLID-PROPELLANT CHARACTERIZATION SO APPLIED SPECTROSCOPY LA English DT Article DE FOURIER TRANSFORM INFRARED SPECTROSCOPY; SOLID PROPELLANTS; PLASTICIZER DEPLETION; GRAPHITE ANALYSIS AB Fourier transform infrared photoacoustic spectroscopy (FT-IR/PAS) has been used to examine surfaces of composite solid propellants. Depletion of crystalline energetic material from extruded surfaces, and of plasticizer from aged surfaces, has been documented. In addition, a method has been developed to determine the mass per unit area of graphite on coated propellant surfaces. RP PESCERODRIGUEZ, RA (reprint author), USA,BALLIST RES LAB,ABERDEEN PROVING GROUND,MD 21005, USA. NR 9 TC 8 Z9 8 U1 1 U2 1 PU SOC APPLIED SPECTROSCOPY PI FREDERICK PA PO BOX 1438, FREDERICK, MD 21701 SN 0003-7028 J9 APPL SPECTROSC JI Appl. Spectrosc. PD MAR-APR PY 1991 VL 45 IS 3 BP 417 EP 419 DI 10.1366/0003702914337074 PG 3 WC Instruments & Instrumentation; Spectroscopy SC Instruments & Instrumentation; Spectroscopy GA FE161 UT WOS:A1991FE16100014 ER PT J AU SPERLING, LC AF SPERLING, LC TI MULTIPLE ECCRINE HIDROCYSTOMAS - A NONSURGICAL TREATMENT - REPLY SO ARCHIVES OF DERMATOLOGY LA English DT Letter RP SPERLING, LC (reprint author), WALTER REED ARMY MED CTR,DERMATOL SERV,WASHINGTON,DC 20307, USA. NR 2 TC 3 Z9 3 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0003-987X J9 ARCH DERMATOL JI Arch. Dermatol. PD MAR PY 1991 VL 127 IS 3 BP 423 EP 424 PG 2 WC Dermatology SC Dermatology GA FA772 UT WOS:A1991FA77200024 ER PT J AU REED, WW DIEHL, LF AF REED, WW DIEHL, LF TI LEUKOPENIA, NEUTROPENIA, AND REDUCED HEMOGLOBIN LEVELS IN HEALTHY AMERICAN BLACKS SO ARCHIVES OF INTERNAL MEDICINE LA English DT Article ID BLOOD-CELL VALUES; UNITED-STATES; ANEMIA; CRITERIA; ADULTS; WHITE AB Hematologic profiles of 462 persons, mostly active-duty service members, were studied to determine whether hematologic differences between blacks and whites exist in a healthy population. Whites had significantly greater mean concentrations of leukocytes (6.73 vs 5.95 x 10(9)/L), neutrophils (3.96 vs 3.16 x 10(9)/L), and hemoglobin (153 vs 135 g/L for men, 147 vs 125 g/L for women). The mean differences were largely due to relatively symmetric shifts in the frequency distributions for these cell concentrations. No significant correlation was found between neutrophil count and morbidity from infection as measured by a standardized questionnaire. The use of separate hematologic reference values for blacks and whites should be considered. C1 WALTER REED ARMY MED CTR,DEPT MED,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,DEPT MED,BETHESDA,MD 20814. NR 27 TC 77 Z9 78 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0003-9926 J9 ARCH INTERN MED JI Arch. Intern. Med. PD MAR PY 1991 VL 151 IS 3 BP 501 EP 505 DI 10.1001/archinte.151.3.501 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA FA768 UT WOS:A1991FA76800011 PM 2001132 ER PT J AU RACINE, CH AHLSTRAND, GM AF RACINE, CH AHLSTRAND, GM TI THAW RESPONSE OF TUSSOCK-SHRUB TUNDRA TO EXPERIMENTAL ALL-TERRAIN VEHICLE DISTURBANCES IN SOUTH-CENTRAL ALASKA SO ARCTIC LA English DT Article DE ALL-TERRAIN VEHICLES; TUNDRA DISTURBANCE; PERMAFROST THAW; EXPERIMENTAL TRAFFIC; ALASKA; WRANGELL-ST ELIAS NATIONAL PARK; SOUTH-CENTRAL ALASKA ID SOIL AB The vehicle-induced subsurface thaw response in a tussock tundra area was experimentally measured in relation to increasing traffic (10, 50 and 150 passes) applied by different types of lightweight (100-450 kg) all-terrain vehicles (ATVs) compared with a heavier (1200 kg) tracked Weasel (M-29) at four different times during the thaw season: 1) early June, 2) early September, 3) at weekly intervals for 10 weeks from mid-June to early September, and 4) in late July of two successive years. Two years later, in August 1987, three frost-table profiles were constructed for each of 144 test lanes 30 m long by probing at 10 cm intervals along three horizontal reference lines. The test site in south-central Alaska is underlain by "warm" permafrost with a 35 cm thick organic horizon over an ice-rich mineral soil. Early in the thaw season when thaw depths are 10-20 cm, traffic by ATVs can produce as much or more subsurface thaw than a heavier Weasel. Later, in September, the Weasel produced more thaw than the ATVs. Traffic intensity (number of passes) also had a greater effect on thaw response in the spring than in the fall. The thaw response produced by traffic driven at weekly intervals throughout the summer was greater than that produced by traffic confined to early June or September. The downward progression of thaw from May to September results in changing soil moisture levels, bearing strengths and compressibility of the organic and mineral soil horizons. C1 NATL PK SERV,ALASKA REG OFF,ANCHORAGE,AK 99503. RP RACINE, CH (reprint author), USA,COLD REG RES & ENGN LAB,HANOVER,NH 03755, USA. NR 12 TC 9 Z9 9 U1 0 U2 4 PU ARCTIC INST N AMER PI CALGARY PA UNIV OF CALGARY 2500 UNIVERSITY DRIVE NW 11TH FLOOR LIBRARY TOWER, CALGARY AB T2N 1N4, CANADA SN 0004-0843 J9 ARCTIC JI Arctic PD MAR PY 1991 VL 44 IS 1 BP 31 EP 37 PG 7 WC Environmental Sciences; Geography, Physical SC Environmental Sciences & Ecology; Physical Geography GA FE778 UT WOS:A1991FE77800005 ER PT J AU ROTHBERG, JM AF ROTHBERG, JM TI STRESS AND SUICIDE IN THE UNITED-STATES-ARMY - EFFECTS OF RELOCATION ON SERVICE MEMBERS MENTAL-HEALTH SO ARMED FORCES & SOCIETY LA English DT Article ID MILITARY FAMILY; IMMIGRATION; PERSONNEL; RATES AB The evidence from sociological and epidemiological studies indicates that people who migrate or move their residence tend to have higher rates of suicide than nonmovers. The periodic reassignment and relocation of soldiers places them, in theory, at higher risk for suicide. There are no prior reports of the relationship between Army moves and suicides. The findings of the current report are that the correlation of moves and suicide is not present for the majority of the soldiers but is present for the youngest third of the Army population. Some aspects of the individual and social dynamics that may influence the relation between relocation and suicide are provided, and some issues about the applicability of status-integration theory to relocation-related suicides are raised. C1 UNIFORMED SERV UNIV HLTH SCI,PSYCHIAT,BETHESDA,MD 20814. RP ROTHBERG, JM (reprint author), WALTER REED ARMY MED CTR,DEPT MIL PSYCHIAT,WASHINGTON,DC 20307, USA. NR 27 TC 10 Z9 10 U1 0 U2 4 PU TRANSACTION PERIOD CONSORTIUM PI NEW BRUNSWICK PA DEPT 3091 RUTGERS-THE STATE UNIV OF NJ, NEW BRUNSWICK, NJ 08903 SN 0095-327X J9 ARMED FORCES SOC JI Armed Forces Soc. PD SPR PY 1991 VL 17 IS 3 BP 449 EP 458 DI 10.1177/0095327X9101700307 PG 10 WC Political Science; Sociology SC Government & Law; Sociology GA HB509 UT WOS:A1991HB50900007 ER PT J AU KAIN, KC ORLANDI, PA LANAR, DE AF KAIN, KC ORLANDI, PA LANAR, DE TI UNIVERSAL PROMOTER FOR GENE-EXPRESSION WITHOUT CLONING - EXPRESSION-PCR SO BIOTECHNIQUES LA English DT Article ID PLASMODIUM-FALCIPARUM; OVERLAP EXTENSION; MESSENGER-RNAS; SEQUENCE; MUTAGENESIS; TRANSLATION; POLYMERASE; ANTIGEN; LEADER AB We present a rapid and simple system called expression-PCR (E-PCR) for in vitro synthesis of functional protein from genomic or plasmid DNA. A universal promoter was developed containing an untranslated leader sequence from alfalfa mosaic virus directly downstream from the T7 bacteriophage promoter. When this universal promoter is spliced to a DNA segment, it produces a suitable template for in vitro transcription and translation. The DNA to be expressed is first amplified by the PCR using a 5'-primer that incorporates an area homologous to the 3'-end of the universal promoter. The universal promoter and this DNA fragment are mixed and re-amplified in a reaction analogous to splicing by overlap extension, generating a recombinant DNA template that can be transcribed and translated in vitro without further processing. Unlike standard methods for in vitro transcription and translation, E-PCR is not dependent upon specialized transcription vectors, cloning, plasmid isolation and purification, or restriction enzyme sites. This approach has been used to synthesize and examine the biological activity of malaria proteins that are vaccine candidates for Plasmodium falciparum. E-PCR represents a significant improvement over current in vitro expression systems, most notably in its time savings, versatility of gene expression and its compatibility with rapid PCR-based site-directed mutagenesis procedures. RP KAIN, KC (reprint author), WALTER REED ARMY MED CTR,DEPT IMMUNOL,WASHINGTON,DC 20307, USA. RI Lanar, David/B-3560-2011 NR 19 TC 52 Z9 53 U1 1 U2 6 PU EATON PUBLISHING CO PI NATICK PA 154 E. CENTRAL ST, NATICK, MA 01760 SN 0736-6205 J9 BIOTECHNIQUES JI Biotechniques PD MAR PY 1991 VL 10 IS 3 BP 366 EP & PG 0 WC Biochemical Research Methods; Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA FB926 UT WOS:A1991FB92600017 PM 2064773 ER EF