FN Thomson Reuters Web of Science™ VR 1.0 PT J AU SCREMIN, OU SHIH, TM CORCORAN, KD AF SCREMIN, OU SHIH, TM CORCORAN, KD TI CEREBRAL-BLOOD-FLOW METABOLISM COUPLING AFTER ADMINISTRATION OF SOMAN AT NONTOXIC LEVELS SO BRAIN RESEARCH BULLETIN LA English DT Article DE SOMAN; ACETYLCHOLINESTERASE INHIBITORS; CEREBROVASCULAR CIRCULATION; CEREBRAL METABOLISM; CEREBRAL HYPEREMIA ID GLUCOSE-UTILIZATION; RAT; BRAIN; VASODILATATION; ACETYLCHOLINE; PHYSOSTIGMINE; INHIBITION AB The effect of soman, an irreversible organophosphorus cholinesterase inhibitor, on regional cerebral blood flow and glucose utilization were studied with a double-tracer, autoradiographic technique in rats. Soman was given at a subtoxic dose of 55-mu-g/kg SC and variables were measured 45 min later. No changes in arterial blood pressure or signs of toxicity were present in the animals studied. Soman induced a pronounced increase in cerebral blood flow. This change was not accompanied by an increase in cerebral metabolism, with exception of superior colliculi. Brain regions showing the more pronounced (greater than 200% over control) increases in blood flow were motor, sensory and temporal cortex, area 18a of the occipital cortex, claustrum, inferior colliculus and cerebellum. These findings differ from those previously reported for the carbamate cholinesterase inhibitor, physostigmine, and constitute the first demonstration of cerebrovascular effects for an organophosphorus cholinesterase inhibitor, soman, at nonsymptomatic doses. C1 USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010. RP SCREMIN, OU (reprint author), VET AFFAIRS MED CTR,151,2100 RIDGECREST DR SE,ALBUQUERQUE,NM 87108, USA. NR 22 TC 17 Z9 17 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0361-9230 J9 BRAIN RES BULL JI Brain Res. Bull. PD MAR PY 1991 VL 26 IS 3 BP 353 EP 356 DI 10.1016/0361-9230(91)90006-6 PG 4 WC Neurosciences SC Neurosciences & Neurology GA FD382 UT WOS:A1991FD38200006 PM 2049601 ER PT J AU SUPROCK, JF VINOPAL, JH SMITH, W AF SUPROCK, JF VINOPAL, JH SMITH, W TI EXTRACTION OF 4 CHLOROPHENOXY ACID HERBICIDES AND PICLORAM FROM SURFACE WIPES SO BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY LA English DT Article ID CHROMATOGRAPHY RP SUPROCK, JF (reprint author), USA,ENVIRONM HYG AGCY,DIV ORGAN ENVIRONM CHEM,ABERDEEN PROVING GROUND,MD 21010, USA. NR 5 TC 1 Z9 1 U1 0 U2 0 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0007-4861 J9 B ENVIRON CONTAM TOX JI Bull. Environ. Contam. Toxicol. PD MAR PY 1991 VL 46 IS 3 BP 392 EP 396 PG 5 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA EY267 UT WOS:A1991EY26700010 PM 2032004 ER PT J AU KUEHL, DT AF KUEHL, DT TI DOUBLE-SHOT YOUR GUNS AND GIVE EM HELL BRAGG,BRAXTON AND THE WAR IN MEXICO SO CIVIL WAR HISTORY LA English DT Article RP KUEHL, DT (reprint author), USA,WASHINGTON,DC 20310, USA. NR 29 TC 1 Z9 1 U1 0 U2 1 PU KENT STATE UNIV PRESS PI KENT PA KENT, OH 44242 SN 0009-8078 J9 CIVIL WAR HIST JI Civil War Hist. PD MAR PY 1991 VL 37 IS 1 BP 51 EP 65 PG 15 WC History SC History GA FB232 UT WOS:A1991FB23200003 ER PT J AU BURCHARTH, HF HOWELL, GL LIU, Z AF BURCHARTH, HF HOWELL, GL LIU, Z TI ON THE DETERMINATION OF CONCRETE ARMOR UNIT STRESSES INCLUDING SPECIFIC RESULTS RELATED TO DOLOSSE SO COASTAL ENGINEERING LA English DT Article ID DYNAMIC LOADING CONDITIONS; STRUCTURAL INTEGRITY AB Failures of rubble mound breakwaters armoured with complex types of unreinforced concrete armour units are often due to breakage. This happens when the stresses exceed the material strength. Sufficient parametric studies of the stresses are not yet available to produce design diagrams for structural integrity. The paper presents a general discussion of the problems related to stress determination and describes the results and the analyses of model tests with 200 kg and 200 g load-cell instrumented Dolosse. Static stresses, wave-generated stresses and stresses due to impacts were studied as well as model and scale effects. Moreover, some results from the Crescent City Prototype Dolosse study are presented and related to results from small-scale model tests. A preliminary design diagram for Dolosse is presented as well. C1 USA,COASTAL ENGN RES CTR,WATERWAYS EXPT STN,ARMY CORPS ENGN,VICKSBURG,MS 39180. RP BURCHARTH, HF (reprint author), AALBORG UNIV,DEPT CIVIL ENGN,SOHNGAARDSHOLMVEJ 57,DK-9000 AALBORG,DENMARK. NR 39 TC 5 Z9 5 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-3839 J9 COAST ENG JI Coast. Eng. PD MAR PY 1991 VL 15 IS 1-2 BP 107 EP 165 DI 10.1016/0378-3839(91)90044-H PG 59 WC Engineering, Civil; Engineering, Ocean SC Engineering GA FE785 UT WOS:A1991FE78500007 ER PT J AU VANDERHOFF, JA AF VANDERHOFF, JA TI SPECIES PROFILES IN SOLID-PROPELLANT FLAMES USING ABSORPTION AND EMISSION-SPECTROSCOPY SO COMBUSTION AND FLAME LA English DT Article ID TRANSITION-PROBABILITIES; COMBUSTION CHEMISTRY; FLUORESCENCE; LIFETIMES; OH AB A windowed strand burner with a propellant feed mechanism has been used to characterize the steady-state burning of two composite propellants, M-30 and HMXl, at moderate pressure. Both emission and absorption spectroscopy have yielded profile data on three important combustion species: OH, NH, and CN. Relative appearances of these three species are inferred from emission intensity profiles, and absolute concentration profiles are calculated from the absorption data. This is the first absolute determination of these combustion intermediates in a propellant flame. The concentration measurements for OH indicate that the propellant flame temperatures are about 200 and 100 K below adiabatic for M-30 and HMXl, respectively. A maximum value of 43 ppm NH is found for the M-30 propellant flame. Fluctuations in the flame front of HMXl compromised the determination of maximum concentrations for NH and CN. RP VANDERHOFF, JA (reprint author), USA,BALLIST RES LABS,DIV INTERIOR BALLIST,ABERDEEN PROVING GROUND,MD 21005, USA. NR 43 TC 12 Z9 12 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0010-2180 J9 COMBUST FLAME JI Combust. Flame PD MAR PY 1991 VL 84 IS 1-2 BP 73 EP 92 DI 10.1016/0010-2180(91)90039-E PG 20 WC Thermodynamics; Energy & Fuels; Engineering, Multidisciplinary; Engineering, Chemical; Engineering, Mechanical SC Thermodynamics; Energy & Fuels; Engineering GA FE940 UT WOS:A1991FE94000007 ER PT J AU DUNCAN, MB JABBARI, B ROSENBERG, ML AF DUNCAN, MB JABBARI, B ROSENBERG, ML TI GAZE-EVOKED VISUAL SEIZURES IN NONKETOTIC HYPERGLYCEMIA SO EPILEPSIA LA English DT Article DE NONKETOTIC HYPERGLYCEMIA; EPILEPTIC SEIZURES; REFLEX EPILEPSY ID NON-KETOTIC HYPERGLYCEMIA; ATTENTION; CORTEX AB Focal motor seizures are commonly a symptom of nonketotic hyperglycemia (NKH). Posture-induced motor seizures are less common but have been reported in some patients with this disorder. We report the first case of gaze-evoked sensory (visual) seizures in nonketotic hyperglycemia. Both seizures and ictal EEG findings disappeared shortly after hyperglycemia was corrected. C1 WALTER REED ARMY MED CTR, NEUROL SERV, NEUROPHYSIOL SECT, WARD 62, WASHINGTON, DC 20307 USA. WALTER REED ARMY MED CTR, NEUROPATHAMOL, WASHINGTON, DC 20307 USA. UNIFORMED SERV UNIV HLTH SCI, BETHESDA, MD 20814 USA. NR 18 TC 20 Z9 21 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0013-9580 EI 1528-1167 J9 EPILEPSIA JI Epilepsia PD MAR-APR PY 1991 VL 32 IS 2 BP 221 EP 224 DI 10.1111/j.1528-1157.1991.tb05248.x PG 4 WC Clinical Neurology SC Neurosciences & Neurology GA FE077 UT WOS:A1991FE07700010 PM 2004626 ER PT J AU SERABIAN, SM ANASTASI, RF AF SERABIAN, SM ANASTASI, RF TI OUT-OF-PLANE DEFLECTIONS OF METALLIC AND COMPOSITE PIN-LOADED COUPONS SO EXPERIMENTAL MECHANICS LA English DT Article ID ORTHOTROPIC PLATES; FAILURE ANALYSIS; BOLTED JOINTS; STRESSES; HOLES; STRENGTH; ELEMENT; DESIGN; MODE AB The projection shadow moire technique was employed to determine an out-of-plane contouring history of aluminum, [(+45/-45)]3s, [(0/90(3),0]s and [(0/90/+45/-45)]2s fiberglass epoxy pin-loaded specimens experimentally. The contouring interval was limited to 0.0254 mm by experimental concerns. Qualification of the projection shadow moire optical arrangement was initially accomplished by the out-of-plane contouring of a clamped, centrally loaded, circular aluminum plate. Experimental results indicate significant out-of-plane displacements in the bearing region of the coupon at load levels well below ultimate. Effects of material anisotropy could be seen in the fiber-oriented shape of the displacement contours. Comparisons with three-dimensional finite-element results indicate that experimental out-of-plane contours were significantly larger than their finite-element counterparts in the region above the pin for the [(+45/-45)]3s, [(0/90)3,O]s laminates. These deviations increased with increasing pin-load level. These variations could be attributed to linear-elastic through-thickness moduli assumptions as well as through-thickness finite-element mesh coarseness. RP SERABIAN, SM (reprint author), USA,SLCMT,MRS,MAT TECH LAB,ARSENAL ST,WATERTOWN,MA 02172, USA. NR 56 TC 1 Z9 1 U1 0 U2 0 PU SOC EXPERIMENTAL MECHANICS PI BETHEL PA 7 SCHOOL STREET, BETHEL, CT 06801 SN 0014-4851 J9 EXP MECH JI Exp. Mech. PD MAR PY 1991 VL 31 IS 1 BP 25 EP 32 DI 10.1007/BF02325719 PG 8 WC Materials Science, Multidisciplinary; Mechanics; Materials Science, Characterization & Testing SC Materials Science; Mechanics GA FH620 UT WOS:A1991FH62000005 ER PT J AU VUONO, CE AF VUONO, CE TI DESERT STORM AND THE FUTURE OF CONVENTIONAL FORCES SO FOREIGN AFFAIRS LA English DT Article RP VUONO, CE (reprint author), USA,WASHINGTON,DC 20310, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU COUNC FOREIGN RELAT INC PI NEW YORK PA 58 E 68TH ST, NEW YORK, NY 10021 SN 0015-7120 J9 FOREIGN AFF JI Foreign Aff. PD SPR PY 1991 VL 70 IS 2 BP 49 EP 68 DI 10.2307/20044709 PG 20 WC International Relations SC International Relations GA FG563 UT WOS:A1991FG56300004 ER PT J AU KADAKIA, SC COHAN, CF STARNES, EC AF KADAKIA, SC COHAN, CF STARNES, EC TI ESOPHAGEAL DILATION WITH POLYVINYL BOUGIES USING A GUIDEWIRE WITH MARKINGS WITHOUT THE AID OF FLUOROSCOPY SO GASTROINTESTINAL ENDOSCOPY LA English DT Article ID BALLOON CATHETER; GASTROINTESTINAL STENOSES; EDER-PUESTOW; DILATATION; STRICTURES; BENIGN; COMPLICATIONS C1 LETTERMAN ARMY MED CTR,SAN FRANCISCO,CA 94128. RP KADAKIA, SC (reprint author), BROOKE ARMY MED CTR,DEPT MED,GASTROENTEROL SERV,FT SAM HOUSTON,TX 78234, USA. NR 25 TC 19 Z9 19 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0016-5107 J9 GASTROINTEST ENDOSC JI Gastrointest. Endosc. PD MAR-APR PY 1991 VL 37 IS 2 BP 183 EP 187 DI 10.1016/S0016-5107(91)70682-2 PG 5 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA FG079 UT WOS:A1991FG07900015 PM 2032605 ER PT J AU SAUCIER, RT AF SAUCIER, RT TI FORMATION OF MIMA MOUNDS - A SEISMIC HYPOTHESIS - COMMENT SO GEOLOGY LA English DT Editorial Material RP SAUCIER, RT (reprint author), USA,ENGINEER WATERWAYS EXPT STN,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 0 TC 4 Z9 4 U1 0 U2 1 PU GEOLOGICAL SOC AMERICA PI BOULDER PA PO BOX 9140 3300 PENROSE PLACE, BOULDER, CO 80301 SN 0091-7613 J9 GEOLOGY JI Geology PD MAR PY 1991 VL 19 IS 3 BP 284 EP 284 DI 10.1130/0091-7613(1991)019<0284:CAROFO>2.3.CO;2 PG 1 WC Geology SC Geology GA EZ388 UT WOS:A1991EZ38800025 ER PT J AU XI, XX VENKATESAN, T LI, Q WU, XD INAM, A CHANG, CC RAMESH, R HWANG, DM RAVI, TS FINDIKOGLU, A HEMMICK, D ETEMAD, S MARTINEZ, JA WILKENS, B AF XI, XX VENKATESAN, T LI, Q WU, XD INAM, A CHANG, CC RAMESH, R HWANG, DM RAVI, TS FINDIKOGLU, A HEMMICK, D ETEMAD, S MARTINEZ, JA WILKENS, B TI PREPARATION OF THIN-FILM HIGH-TEMPERATURE SUPERCONDUCTORS SO IEEE TRANSACTIONS ON MAGNETICS LA English DT Article; Proceedings Paper CT 1990 APPLIED SUPERCONDUCTIVITY CONF CY SEP 24-28, 1990 CL SNOWMASS, CO SP TELEDYNE WAH CHANG ALBANY, US DOE, HYPRES, GEN DYNAM ID PULSED LASER DEPOSITION; HIGH-TC; GROWTH; EVAPORATION; DEVICES AB Fundamental issues in preparing high quality high T(c) YBa2Cu3O7-x thin films are addressed. The techniques of inverted cylindrical magnetron sputtering and pulsed laser deposition are chosen as successful examples to illustrate how the key problems can be solved. The fabrication of YBa2Cu3O7-x/PrBa2Cu3O7-x superlattices where superconductivity in a single unit cell layer of YBa2Cu3O7-x was observed demonstrates the state of the art of thin film deposition of high T(c) materials. Systematic variations of the deposition parameters result in changes of superconducting and structural properties of the films that correlate with their microwave and infrared characteristics. C1 BELLCORE,RED BANK,NJ 07701. UNIV CALIF LOS ALAMOS SCI LAB,ERDC,LOS ALAMOS,NM 87545. RP XI, XX (reprint author), RUTGERS STATE UNIV,DEPT PHYS,PISCATAWAY,NJ 08854, USA. RI Venkatesan, Thirumalai/E-1667-2013 NR 38 TC 32 Z9 33 U1 0 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9464 J9 IEEE T MAGN JI IEEE Trans. Magn. PD MAR PY 1991 VL 27 IS 2 BP 982 EP 989 DI 10.1109/20.133345 PN 2 PG 8 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA EY652 UT WOS:A1991EY65200043 ER PT J AU LI, Q XI, XX WU, XD INAM, A VADLAMANNATI, S RAMESH, R SHWARTZ, S HWANG, DM WILKENS, B MARTINEZ, JA MCLEAN, WL VENKATESAN, T AF LI, Q XI, XX WU, XD INAM, A VADLAMANNATI, S RAMESH, R SHWARTZ, S HWANG, DM WILKENS, B MARTINEZ, JA MCLEAN, WL VENKATESAN, T TI SUPERCONDUCTIVITY IN YBA2CU3O7/PRBA2CU3O7 SUPERLATTICES SO IEEE TRANSACTIONS ON MAGNETICS LA English DT Article; Proceedings Paper CT 1990 CONF ON APPLIED SUPERCONDUCTIVITY CY SEP 24-28, 1990 CL SNOWMASS, CO ID TRANSITION; CRYSTALS; FILMS AB High quality YBa2Cu3O7/PrBa2Cu3O7 superlattices with desired thickness of each component were fabricated by laser deposition. Superconductivity was studied by varying both YBa2Cu3O7 and PrBa2Cu3O7 layer thicknesses. The results indicated that an isolated single unit cell YBa2Cu3O7 layer (nominal thickness of 12 angstrom) is superconducting. The increase of T(c) from the lower value of a single unit cell layer to 90 K in thick films and the enhancement of T(c) for a given thickness of YBa2Cu3O7 when the PrBa2Cu3O7 layers decreased to less than approximately 30 angstrom could be attributed to the interlayer coupling effect. Superconducting transitions of superlattices in applied magnetic fields were studied. The interlayer coupling effect on vortices can be seen by comparing the transition curves in high magnetic fields of thick film, ultrathin film and superlattice. For the samples with very thin YBa2Cu3O7 layers, similar results to vortex-antivortex pair phase transition was observed by measuring the temperature dependence of resistance, magnetoresistance, and I-V curves, indicating a strong two dimensional behavior in very thin YBa2Cu3O7 films. C1 BELLCORE,RED BANK,NJ 07701. UNIV CALIF LOS ALAMOS SCI LAB,ERDC,LOS ALAMOS,NM 87545. RP LI, Q (reprint author), RUTGERS STATE UNIV,DEPT PHYS,PISCATAWAY,NJ 08854, USA. RI Venkatesan, Thirumalai/E-1667-2013 NR 14 TC 4 Z9 4 U1 0 U2 2 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9464 J9 IEEE T MAGN JI IEEE Trans. Magn. PD MAR PY 1991 VL 27 IS 2 BP 2472 EP 2475 DI 10.1109/20.133988 PN 3 PG 4 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA EY653 UT WOS:A1991EY65300201 ER PT J AU MCMILLAN, RW TRUSSELL, CW BOHLANDER, RA BUTTERWORTH, JC FORSYTHE, RE AF MCMILLAN, RW TRUSSELL, CW BOHLANDER, RA BUTTERWORTH, JC FORSYTHE, RE TI AN EXPERIMENTAL 225 GHZ PULSED COHERENT RADAR SO IEEE TRANSACTIONS ON MICROWAVE THEORY AND TECHNIQUES LA English DT Article ID DESIGN AB An experimental coherent pulsed radar operating at 225 GHz is described. This system uses a pulsed, phase-locked extended interaction oscillator transmitter and an f/4 (frequency divided by 4) subharmonic mixer pumped by a phase-locked Gunn oscillator as the receiver. A quasi-optical circular polarization duplexer combines transmitter and receiver signals into the same antenna. Results obtained with this system include the detection of targets out to ranges of 3.5 km and observation of Doppler spectra of trucks and tracked vehicles, including contributions from both body and tracks. C1 USA,COMMUN ELECTR COMMAND,CTR NIGHT VIS & ELECTROOPT,FT BELVOIR,VA 22060. FORSYTHE TECHNOL,ATLANTA,GA. RP MCMILLAN, RW (reprint author), GEORGIA INST TECHNOL,ATLANTA,GA 30332, USA. NR 18 TC 25 Z9 29 U1 2 U2 3 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9480 J9 IEEE T MICROW THEORY JI IEEE Trans. Microw. Theory Tech. PD MAR PY 1991 VL 39 IS 3 BP 555 EP 562 DI 10.1109/22.75300 PG 8 WC Engineering, Electrical & Electronic SC Engineering GA FB860 UT WOS:A1991FB86000023 ER PT J AU CHANH, TC HEWETSON, JF AF CHANH, TC HEWETSON, JF TI STRUCTURE-FUNCTION STUDIES OF T-2-MYCOTOXIN WITH A MONOCLONAL-ANTIBODY SO IMMUNOPHARMACOLOGY LA English DT Article DE T-2-MYCOTOXIN; MONOCLONAL ANTIBODY; STRUCTURE FUNCTION STUDIES ID IDIOTYPIC ANTIBODIES; T-2 AB A BALB/C murine monoclonal antibody (mAb) specific for the trichothecene mycotoxin T-2 was previously generated. The anti-T-2 antibody, designated HD11, can detect T-2 in the nanogram range employing an enzyme-linked immuno-sorbent assay. The HD11 antibody at a concentration of 1-mu-g/ml completely protected against the T-2-induced cytotoxicity of the human epidermoid carcinoma cell lines Hep-2 and KB. Fine specificity analysis was performed using 10 structurally related T-2 metabolites to inhibit the specific binding of HD11 to T-2 mycotoxin. The results suggest a binding specificity of the protective HD11 antibody for the bulky hydrophobic alkyl side chain at position R5 and the acetyl groups at positions R2 and R3 of the T-2 mycotoxin molecule. HD11 anti-T-2 mAb, which bound to the T-2 metabolite acetyl T-2 (with a substituted acetyl group at R1 position), efficiently neutralized its in vitro cytotoxicity. On the other hand, the cytotoxicity of T-2 metabolites neosalaniol and 3' OH HT-2, both of which lack the alkyl side chain at position R5 and which did not bind to HD11, was unaffected by HD11. C1 USA,MED RES INST INFECT DIS,FREDERICK,MD 21701. RP CHANH, TC (reprint author), SW FDN BIOMED RES,DEPT VIROL & IMMUNOL,POB 28147,SAN ANTONIO,TX 78228, USA. NR 7 TC 7 Z9 8 U1 1 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0162-3109 J9 IMMUNOPHARMACOLOGY JI Immunopharmacology PD MAR-APR PY 1991 VL 21 IS 2 BP 83 EP 89 DI 10.1016/0162-3109(91)90011-M PG 7 WC Immunology; Pharmacology & Pharmacy SC Immunology; Pharmacology & Pharmacy GA FL958 UT WOS:A1991FL95800002 PM 1880019 ER PT J AU SPERLING, LC AF SPERLING, LC TI INFLAMMATORY TINEA-CAPITIS (KERION) MIMICKING DISSECTING CELLULITIS - OCCURRENCE IN 2 ADOLESCENTS SO INTERNATIONAL JOURNAL OF DERMATOLOGY LA English DT Article ID ADULTS AB Tinea capitis is unusual in postpubertal individuals and is frequently misdiagnosed. In cases of inflammatory disease, prompt initiation of therapy is essential to prevent scarring and permanent hair loss. Two examples are presented to illustrate principles of evaluation and treatment. RP SPERLING, LC (reprint author), WALTER REED ARMY MED CTR,DERMATOL SERV,WASHINGTON,DC 20307, USA. NR 10 TC 24 Z9 25 U1 0 U2 0 PU DECKER PERIODICALS INC PI HAMILTON PA 4 HUGHSON STREET SOUTH PO BOX 620, LCD 1, HAMILTON ON L8N 3K7, CANADA SN 0011-9059 J9 INT J DERMATOL JI Int. J. Dermatol. PD MAR PY 1991 VL 30 IS 3 BP 190 EP 192 DI 10.1111/j.1365-4362.1991.tb03849.x PG 3 WC Dermatology SC Dermatology GA EZ235 UT WOS:A1991EZ23500007 PM 2037403 ER PT J AU CARTLAND, HE JOHNSON, TH AF CARTLAND, HE JOHNSON, TH TI SCALING OF THE ELECTRON-BEAM-PUMPED XENON CHLORIDE LASER SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID NOBLE-GAS HALIDES; XECL; EXCITATION; EMISSION; MIXTURES; HCL AB A comprehensive kinetics and extraction model of electron-beam-excited xenon chloride lasers is used to examine the feasibility of constructing a megajoule-class excimer laser. The ratio of small-signal gain to absorption scales nearly logarithmically with pump rate over the range studied, 10 kW/cm3 to 1 MW/cm3, and limits extraction efficiency to 20%-50%. Active volume dimensions are practically constrained to 1-2 m in length and to approximately 2 m in width, with efficient extraction possible for pulse lengths of 2-mu-s or less. Single modules operating in the technologically conservative, low-pump-power less-than-or-equal-to 100 kW/cm3) regime should be capable of producing pulse energies of 40 kJ. RP CARTLAND, HE (reprint author), US MIL ACAD,SCI RES LAB,W POINT,NY 10996, USA. NR 29 TC 0 Z9 0 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD MAR 1 PY 1991 VL 69 IS 5 BP 2815 EP 2825 DI 10.1063/1.348616 PG 11 WC Physics, Applied SC Physics GA FA705 UT WOS:A1991FA70500009 ER PT J AU DEFRANK, JJ CHENG, TC AF DEFRANK, JJ CHENG, TC TI PURIFICATION AND PROPERTIES OF AN ORGANOPHOSPHORUS ACID ANHYDRASE FROM A HALOPHILIC BACTERIAL ISOLATE SO JOURNAL OF BACTERIOLOGY LA English DT Article ID ENZYME AB A moderately halophilic bacterial isolate has been found to possess high levels of enzymatic activity against several highly toxic organophosphorus compounds. The predominant enzyme, designated organophosphorus acid anhydrase 2, has been purified 1,000-fold to homogeneity and characterized. The enzyme is a single polypeptide with a molecular weight of 60,000. With diisopropylfluorophosphate as a substrate, the enzyme has optimum activity at pH 8.5 and 50-degrees-C, and it is stimulated by manganese and cobalt. RP DEFRANK, JJ (reprint author), USA,CTR CHEM RES DEV & ENGN,DIV BIOTECHNOL,RES DIRECTORATE,ABERDEEN PROVING GROUND,MD 21010, USA. NR 15 TC 91 Z9 96 U1 2 U2 5 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0021-9193 J9 J BACTERIOL JI J. Bacteriol. PD MAR PY 1991 VL 173 IS 6 BP 1938 EP 1943 PG 6 WC Microbiology SC Microbiology GA FB988 UT WOS:A1991FB98800014 PM 2001997 ER PT J AU DRAKEFORD, MK PETTINE, KA BROOKSHIRE, L EBERT, F AF DRAKEFORD, MK PETTINE, KA BROOKSHIRE, L EBERT, F TI SPINAL NARCOTICS FOR POSTOPERATIVE ANALGESIA IN TOTAL JOINT ARTHROPLASTY - A PROSPECTIVE-STUDY SO JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME LA English DT Article ID POST-OPERATIVE PAIN; INTRATHECAL MORPHINE; EPIDURAL MORPHINE; RELIEF; UNDERTREATMENT; INJECTION; SULFATE AB Sixty patients who were scheduled to have an elective total hip or knee arthroplasty were randomly assigned to one of the three groups of twenty patients each before operation with spinal anesthesia. A double-blind technique was used throughout the study. The patients in Group 1 (control group) received hyperbaric 1 per cent tetracaine with epinephrine as the subarachnoid spinal anesthetic; the patients in Group II (morphine group), hyperbaric 1 per cent tetracaine with epinephrine and a single subarachnoid dose of Duramorph (morphine sulphate), 0.5 milligram; and those in Group III (Dilaudid group), hyperbaric 1 per cent tetracaine with epinephrine and a single subarachnoid dose of Dilaudid (hydromorphone hydrochloride), 0.002 milligram per kilogram of body weight. During the first twenty-four hours after the operation, the patients in Group II and Group III had significantly less pain compared with those in Group I. This was shown by the use of a visual linear-analog pain scale (p < 0.05), the patients' ratings of the quality of relief of pain (p < 0.02), and comparative measurements of the pain-altering medications that were used (p < 0.05). The patients in Group II and Group III did not have any more complications or side effects than those in Group I. There was no significant difference in the quality and duration of analgesia between Group II and Group III. C1 EISENHOWER ARMY MED CTR,FT GORDON,GA. NR 36 TC 24 Z9 26 U1 0 U2 1 PU JOURNAL BONE JOINT SURGERY INC PI NEEDHAM PA 20 PICKERING ST, NEEDHAM, MA 02192 SN 0021-9355 J9 J BONE JOINT SURG AM JI J. Bone Joint Surg.-Am. Vol. PD MAR PY 1991 VL 73A IS 3 BP 424 EP 428 PG 5 WC Orthopedics; Surgery SC Orthopedics; Surgery GA FD859 UT WOS:A1991FD85900013 PM 1705938 ER PT J AU TSENG, YCL BURMAN, KD LAHIRI, S ABDELRAHIM, MM DAVIS, JC WARTOFSKY, L AF TSENG, YCL BURMAN, KD LAHIRI, S ABDELRAHIM, MM DAVIS, JC WARTOFSKY, L TI THYROTROPIN MODULATES RECEPTOR-MEDIATED PROCESSING OF THE ATRIAL-NATRIURETIC-PEPTIDE RECEPTOR IN CULTURED THYROID-CELLS SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM LA English DT Article ID EPIDERMAL GROWTH-FACTOR; SMOOTH-MUSCLE CELLS; INSULIN DEGRADATION; INTERNALIZATION; RAT; METABOLISM; BINDING; HEART AB In a prior study of atrial natriuretic peptide (ANP) binding to cultured thyroid cells, we reported that at 4 C, more than 95% of bound ANP is recovered on cell membranes, with negligible ANP internalization observed. Since ANP binding was inhibited by TSH, we have further studied TSH effects on postbinding ANP processing to determine whether this phenomenon reflects enhanced endocytosis of the ANP-receptor complex. An ANP chase study was initiated by binding [I-125] ANP to thyroid cells at 4 C for 2 h, followed by incubation at 37 C. ANP processing was then traced by following I-125 activity at various time intervals in three fractions: cell surface membranes, incubation medium, and inside the cells. Radioactivity released into medium represented processed ANP rather than ANP dissociated from surface membranes, since prebound [I-125]ANP could not be competitively dissociated by a high concentration of ANP (1-mu-mol/L) at 37 C. Chase study results showed that prebound ANP quickly disappeared from cell membranes down to 34% by 30 min. Internalized ANP peaked at 10 min, with 21% of initial prebound ANP found inside the cells. At the same time, radioactivity recovered in incubation medium sharply increased between 10-30 min from 8% to 52%. Preincubation of cells with chloroquine (which blocks degradation of the ANP-receptor complex by inhibiting lysosomal hydrolase) caused a 146% increase in internalized [I-125]ANP by 30 min (39% compared to 15% control), while medium radioactivity decreased from 52% to 16%, suggesting that processing of the receptor complex is mediated via lysosomal enzymes. In chase studies employing cells pretreated with chloroquine, TSH stimulated the internalization rate of ANP-receptor complex. By 30 min, TSH significantly reduced the membrane-bound ANP, and the decrease was inversely correlated to the increase in internalized radioactivity. In the absence of ANP ligand, TSH also modulated receptor translocation, resulting in decreased receptor number on surface membrane. However, TSH did not affect ANP degradation on the basis of analysis by immunoprecipitation and high performance liquid chromatography. Taken together, these data suggest that TSH down-regulates ANP receptor on thyroid cell surface membranes, and that an ANP degradative pathway exists which is not mediated through receptor binding. C1 WALTER REED ARMY MED CTR, DEPT MED, WASHINGTON, DC 20307 USA. WALTER REED ARMY MED CTR, DEPT SURG, WASHINGTON, DC 20307 USA. WALTER REED ARMY MED CTR, DEPT CLIN INVEST, WASHINGTON, DC 20307 USA. UNIFORMED SERV UNIV HLTH SCI, DEPT MED, BETHESDA, MD 20814 USA. NR 24 TC 8 Z9 8 U1 0 U2 0 PU ENDOCRINE SOC PI CHEVY CHASE PA 8401 CONNECTICUT AVE, SUITE 900, CHEVY CHASE, MD 20815-5817 USA SN 0021-972X J9 J CLIN ENDOCR METAB JI J. Clin. Endocrinol. Metab. PD MAR PY 1991 VL 72 IS 3 BP 669 EP 674 PG 6 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA FA523 UT WOS:A1991FA52300022 PM 1847707 ER PT J AU CARNAHAN, A FANNING, GR JOSEPH, SW AF CARNAHAN, A FANNING, GR JOSEPH, SW TI AEROMONAS-JANDAEI (FORMERLY GENOSPECIES DNA GROUP-9 A-SOBRIA), A NEW SUCROSE-NEGATIVE SPECIES ISOLATED FROM CLINICAL SPECIMENS SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID MESOPHILIC AEROMONADS; DISEASE SPECTRUM; IDENTIFICATION; HYDROPHILA; ENTEROBACTERIACEAE; VIRULENCE; NOV AB A large numerical taxonomy study conducted in 1988 of 165 mostly clinical Aeromonas strains from diverse geographic sources produced a cluster (S = 84%, S(SM)) of four sucrose-negative strains that included the DNA definition strain for DNA group 9 A. sobria (CDC 0787-80). These four strains, together with five additional strains received in 1989, were subjected to DNA-DNA hybridization (hydroxyapatite, P-32, 60 and 75-degrees-C), and all eight strains were closely related to the ninth labeled DNA group 9 definition strain CDC 0787-80 (73 to 86% relatedness at 60-degrees-C and 68 to 80% relatedness at 75-degrees-C; percent divergence, 2.0 to 3.5). Type strains and DNA definition strains for all other established Aeromonas species were only 35 to 72% related (60-degrees-C) to CDC 0787-80. We propose the name Aeromonas jandaei for this highly related group of nine strains, formerly known as DNA group 9 A. sobria. The type strain was designated ATCC 49568 (CDC 0787-80). The nine strains were examined at 36-degrees-C and were found to be resistant to 0/129 (vibriostatic agent) and uniformly positive for oxidase, gas production from glucose, indole, lysine decarboxylase, arginine dihydrolase, o-nitrophenyl-beta-D-galactopyranoside, motility (25-degrees-C), nitrate reduction, citrate utilization, hemolysis on sheep blood agar, and growth in Trypticase soy broth with no added NaCl. They all fermented D-glucose, D-mannitol, and mannose but did not ferment sucrose, cellobiose, L-arabinose, inositol, salicin, or D-sorbitol. They were uniformly negative for esculin and urea hydrolysis, elastase production, ornithine decarboxylation, and the string test. The antibiogram of A. jandaei resembled that of other aeromonads (resistance to ampicillin and cephalothin), but it differed from most other aeromonads because of resistance to a single dilution of colistin and differed from clinical A. veronii biogroup sobria (formerly A. sobria) by its nearly uniform resistance to cephalothin. The esculin-, sucrose-, and cellobiose-negative and colistin-resistant profile distinguished A. jandaei from other Aeromonas species. These A. jandaei strains were isolated from blood (two strains), wounds (two strains), diarrheal stools (four strains), and a prawn (one strain). The blood and wound isolates, in particular, suggest that there is a possible clinical significance for this species and justify identification of and further research on this group of motile aeromonads. C1 UNIV MARYLAND,DEPT MICROBIOL,COLLEGE PK,MD 20742. WALTER REED ARMY MED CTR,DIV PATHOL,WASHINGTON,DC 20307. NR 28 TC 83 Z9 87 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD MAR PY 1991 VL 29 IS 3 BP 560 EP 564 PG 5 WC Microbiology SC Microbiology GA EY463 UT WOS:A1991EY46300028 PM 2037673 ER PT J AU JOSEPH, SW CARNAHAN, AM BRAYTON, PR FANNING, GR ALMAZAN, R DRABICK, C TRUDO, EW COLWELL, RR AF JOSEPH, SW CARNAHAN, AM BRAYTON, PR FANNING, GR ALMAZAN, R DRABICK, C TRUDO, EW COLWELL, RR TI AEROMONAS-JANDAEI AND AEROMONAS-VERONII DUAL INFECTION OF A HUMAN WOUND FOLLOWING AQUATIC EXPOSURE SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID MESOPHILIC AEROMONADS; SOBRIA; SUSCEPTIBILITY; ASSOCIATION; VIRULENCE AB Exudate removed from an infection that developed below the left eye of a 10-year-old male following a previously inflicted wound after aquatic exposure was cultured and revealed two different Aeromonas spp. Further characterization showed that one strain was phenotypically identical to Aeromonas veronii, while the other strain was confirmed by DNA hybridization analysis to be Aeromonas jandaei sp. nov. This is the first report of these more recently described aeromonads, thus far rarely reported from clinical disease, occurring simultaneously in a human infection. C1 UNIV MARYLAND,MARYLAND BIOTECHNOL INST,COLLEGE PK,MD 20742. WALTER REED ARMY MED CTR,DIV PATHOL,WASHINGTON,DC 20307. RP JOSEPH, SW (reprint author), UNIV MARYLAND,DEPT MICROBIOL,COLLEGE PK,MD 20742, USA. NR 25 TC 46 Z9 55 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD MAR PY 1991 VL 29 IS 3 BP 565 EP 569 PG 5 WC Microbiology SC Microbiology GA EY463 UT WOS:A1991EY46300029 PM 2037674 ER PT J AU SEAL, LA TOYAMA, PS FLEET, KM LERUD, KS HETH, SR MOORMAN, AJ WOODS, JC HILL, RB AF SEAL, LA TOYAMA, PS FLEET, KM LERUD, KS HETH, SR MOORMAN, AJ WOODS, JC HILL, RB TI COMPARISON OF STANDARD CULTURE METHODS, A SHELL VIAL ASSAY, AND A DNA PROBE FOR THE DETECTION OF HERPES-SIMPLEX VIRUS SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID LINKED IMMUNOSORBENT-ASSAY; CLINICAL SPECIMENS; RAPID DIAGNOSIS; CELL-CULTURE; INFECTIONS; ACYCLOVIR AB A nonradioactive, biotinylated herpes simplex virus (HSV) DNA probe, a shell vial (rabbit kidney cell) culture assay enhanced by a direct fluorescent (HSV monoclonal)-antibody stain at 16 to 20 h postinoculation, and conventional tube cultures with confirmation via HSV-specific (polyclonal antibody) immunoperoxidase assay were compared for 199 specimens. The predictive values of the positive results were 54.5% for the probe, 95.9% for the shell vial assay, and 100% for the conventional culture methods, while the predictive values of the negative tests were 68.1, 84.0, and 98.4%, respectively. We conclude that the DNA probe (sensitivity, 24.5%; specificity, 88.3%) and the shell vial assay (sensitivity, 66.2%; specificity, 98.4%) cannot be substituted for conventional tube culture techniques (sensitivity, 97.1%; specificity, 100%) in the routine identification of HSV in our laboratory. C1 TRIPLER ARMY MED CTR,AREA LAB SERV,HONOLULU,HI 96859. TRIPLER ARMY MED CTR,DEPT OBSTET & GYNECOL,HONOLULU,HI 96859. RP SEAL, LA (reprint author), TRIPLER ARMY MED CTR,DEPT PATHOL,HONOLULU,HI 96859, USA. NR 22 TC 5 Z9 6 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD MAR PY 1991 VL 29 IS 3 BP 650 EP 652 PG 3 WC Microbiology SC Microbiology GA EY463 UT WOS:A1991EY46300049 PM 1645373 ER PT J AU BRANSTROM, AA WARREN, RL AF BRANSTROM, AA WARREN, RL TI GENETIC-HETEROGENEITY IN STRAINS OF PSEUDOMONAS-AERUGINOSA FROM PATIENTS WITH CYSTIC-FIBROSIS - REPLY SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Letter ID PROBE C1 WALTER REED ARMY MED CTR,DEPT BACTERIAL DIS,DIV COMMUN DIS & IMMUNOL,WASHINGTON,DC 20307. RP BRANSTROM, AA (reprint author), WALTER REED ARMY MED CTR,DEPT BACTERIAL IMMUNOL,WASHINGTON,DC 20307, USA. NR 7 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD MAR PY 1991 VL 29 IS 3 BP 664 EP 665 PG 2 WC Microbiology SC Microbiology GA EY463 UT WOS:A1991EY46300056 ER PT J AU DIEHL, LF HOPPER, KD GIGUERE, J GRANGER, E LESAR, M AF DIEHL, LF HOPPER, KD GIGUERE, J GRANGER, E LESAR, M TI THE PATTERN OF INTRATHORACIC HODGKINS-DISEASE ASSESSED BY COMPUTED-TOMOGRAPHY SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Article ID CT C1 UNIFORMED SERV UNIV HLTH SCI,DEPT MED,BETHESDA,MD 20814. UNIFORMED SERV UNIV HLTH SCI,DEPT RADIOL,BETHESDA,MD 20814. FITZSIMMONS ARMY MED SERV,DEPT RADIOL,AURORA,CO. FITZSIMMONS ARMY MED SERV,HEMATOL ONCOL SERV,AURORA,CO. RP DIEHL, LF (reprint author), WALTER REED ARMY MED CTR,HEMATOL ONCOL SERV,WASHINGTON,DC 20307, USA. NR 17 TC 28 Z9 28 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0732-183X J9 J CLIN ONCOL JI J. Clin. Oncol. PD MAR PY 1991 VL 9 IS 3 BP 438 EP 443 PG 6 WC Oncology SC Oncology GA EZ656 UT WOS:A1991EZ65600012 PM 1999713 ER PT J AU YANCEY, MK BRADY, K READ, JA AF YANCEY, MK BRADY, K READ, JA TI SONOGRAPHIC EVIDENCE OF FETAL HYDROTHORAX AFTER INUTERO DEATH OF MONOZYGOTIC TWIN SO JOURNAL OF CLINICAL ULTRASOUND LA English DT Article ID PLEURAL EFFUSIONS; PREGNANCY; DECOMPRESSION C1 USA,MADIGAN MED CTR,DEPT OBSTET & GYNECOL,HSHJ OG,TACOMA,WA 98431. NR 13 TC 0 Z9 0 U1 0 U2 0 PU JOHN WILEY & SONS INC PI NEW YORK PA 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0091-2751 J9 J CLIN ULTRASOUND JI J. Clin. Ultrasound PD MAR-APR PY 1991 VL 19 IS 3 BP 162 EP 166 DI 10.1002/jcu.1870190307 PG 5 WC Acoustics; Radiology, Nuclear Medicine & Medical Imaging SC Acoustics; Radiology, Nuclear Medicine & Medical Imaging GA EY460 UT WOS:A1991EY46000006 PM 1849923 ER PT J AU SHEALL, IL AF SHEALL, IL TI REDUCING COSTS AND IMPROVING THE INDUSTRY - GOALS OF THE DREDGING RESEARCH-PROGRAM OF THE UNITED-STATES SO JOURNAL OF COASTAL RESEARCH LA English DT Article DE DISPOSAL SITES; DREDGED MATERIAL PLACEMENT; DREDGE PLANT EQUIPMENT; DREDGING OPERATIONS; DREDGING TECHNOLOGY TRANSFER; NAVIGATIONAL DREDGING AB The following is an overview of the U.S. Army Corps of Engineers Dredging Research Program conducted at the U.S. Army Engineer Waterways Experiment Station, Vicksburg, MS. The article consists of background information, the managerial structure and the specific work units of the Dredging Research Program. RP SHEALL, IL (reprint author), USA,ENGINEER WATERWAYS EXPT STN,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU COASTAL EDUCATION & RESEARCH FOUNDATION PI LAWRENCE PA 810 EAST 10TH STREET, LAWRENCE, KS 66044 SN 0749-0208 J9 J COASTAL RES JI J. Coast. Res. PD SPR PY 1991 VL 7 IS 2 BP 535 EP 542 PG 8 WC Environmental Sciences; Geography, Physical; Geosciences, Multidisciplinary SC Environmental Sciences & Ecology; Physical Geography; Geology GA FD868 UT WOS:A1991FD86800017 ER PT J AU BOGETTI, TA GILLESPIE, JW AF BOGETTI, TA GILLESPIE, JW TI 2-DIMENSIONAL CURE SIMULATION OF THICK THERMOSETTING COMPOSITES SO JOURNAL OF COMPOSITE MATERIALS LA English DT Article ID STRESSES AB An investigation into the two-dimensional cure simulation of thick thermo-setting composites is presented. Temperature and degree of cure distributions within arbitrary cross-sectional geometries are predicted as a function of the autoclave temperature history. The heat conduction equation for two-dimensional, transient anisotropic heat transfer is coupled to the cure kinetics of the thermosetting composite material. A heat generation term, expressed as a function of cure rate and the total heat of reaction, is introduced to account for the heat liberated during the curing process. A generalized boundary condition formulation is employed, enabling arbitrary temperature boundary conditions to be enforced straightforwardly. An incremental, transient finite difference solution scheme is implemented to solve the pertinent governing equations and boundary conditions. The boundary-fitted coordinate system (BFCS) transformation technique is combined with the Alternating Direction Explicit (ADE) finite difference method in the solution strategy. Complex gradients in temperature and degree of cure are predicted and the influence of the tool on the curing process is demonstrated. Correlation between experimentally measured and predicted through-the-thickness temperature profiles in glass/polyester laminates are presented for various arbitrary temperature cure cycle histories. Several typical glass/polyester and graphite/epoxy structural elements of arbitrary cross-section (ply-drop and angle bend) are analyzed to provide insight into the non-uniform curing process unique to thick-sections. Spatial gradients in degree of cure are shown to be strongly dependent on part geometry, thermal anisotropy, cure kinetics and the temperature cure cycle. These spatial gradients directly influence the quality and in-service performance of the finished component by inducing warpage and residual stress during the curing process. C1 UNIV DELAWARE,CTR COMPOSITE MAT,DEPT MECH ENGN,NEWARK,DE 19716. RP BOGETTI, TA (reprint author), USA,BALLIST RES LABS,ABERDEEN PROVING GROUND,MD 21005, USA. NR 29 TC 133 Z9 160 U1 2 U2 12 PU TECHNOMIC PUBL CO INC PI LANCASTER PA 851 NEW HOLLAND AVE, BOX 3535, LANCASTER, PA 17604 SN 0021-9983 J9 J COMPOS MATER JI J. Compos Mater. PD MAR PY 1991 VL 25 IS 3 BP 239 EP 273 PG 35 WC Materials Science, Composites SC Materials Science GA FD933 UT WOS:A1991FD93300002 ER PT J AU MEYER, CA KRANSDORF, MJ JELINEK, JS MOSER, RP AF MEYER, CA KRANSDORF, MJ JELINEK, JS MOSER, RP TI MR AND CT APPEARANCE OF NODULAR FASCIITIS SO JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY LA English DT Article DE BONES, NEOPLASMS; MUSCLES, NEOPLASMS; FASCIITIS, NODULAR; EXTREMITIES, NEOPLASMS; MAGNETIC RESONANCE IMAGING ID SOFT-TISSUE TUMORS; MASSES; BONE AB Nodular fasciitis is a common soft-tissue tumor that remains almost unreported in the radiology literature. We retrospectively reviewed all available imaging studies on three patients with nodular fasciitis studied by MR at our institution. The lesions were round to oval in configuration, ranging in size from 1 to 4.5 cm. Two were intramuscular and one was subcutaneous in location. Both intramuscular lesions were poorly defined on CT, with a tissue attenuation less than that of skeletal muscle. The single subcutaneous lesion was well defined by surrounding fat. Conversely, all lesions were well defined on MR, although the appearance was otherwise nonspecific and varied according to the histology of the lesion. Both intramuscular lesions were mucoid or cellular and were hyperintense to skeletal muscle on T1-weighted and hyperintense to fat on T2-weighted spin-echo (SE) MR images. The subcutaneous lesion was fibrous and markedly hypointense to skeletal muscle on all SE pulse sequences. Findings on three-phase bone scan, arteriography, and ultrasound are discussed. Because there are no unique radiologic findings in nodular fasciitis, this entity must be included in the preoperative differential diagnosis of small soft-tissue masses occurring in the extremities of young adults. C1 ARMED FORCES INST PATHOL,DEPT RADIOL PATHOL,WASHINGTON,DC 20306. WALTER REED ARMY MED CTR,DEPT RADIOL,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,DEPT RADIOL & NUCL MED,BETHESDA,MD 20814. PENN STATE UNIV,MILTON S HERSHEY MED CTR,DEPT RADIOL,HERSHEY,PA 17033. NR 11 TC 51 Z9 52 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0363-8715 J9 J COMPUT ASSIST TOMO JI J. Comput. Assist. Tomogr. PD MAR-APR PY 1991 VL 15 IS 2 BP 276 EP 279 DI 10.1097/00004728-199103000-00017 PG 4 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA FD779 UT WOS:A1991FD77900017 PM 2002108 ER PT J AU LEGREE, PJ GILLIS, PD AF LEGREE, PJ GILLIS, PD TI PRODUCT EFFECTIVENESS EVALUATION CRITERIA FOR INTELLIGENT TUTORING SYSTEMS SO JOURNAL OF COMPUTER-BASED INSTRUCTION LA English DT Article RP LEGREE, PJ (reprint author), USA,BEHAV & SOCIAL SCI RES INST,ATTN PERI IG,BLDG 41203,FT GORDON,GA 30905, USA. NR 12 TC 4 Z9 4 U1 1 U2 1 PU ADCIS INT HEADQUARTERS PI COLUMBUS PA 1601 WEST FIFTH AVE, SUITE 111, COLUMBUS, OH 43212 SN 0098-597X J9 J COMPUT-BASE INSTR PD SPR PY 1991 VL 18 IS 2 BP 57 EP 62 PG 6 WC Education & Educational Research SC Education & Educational Research GA FN430 UT WOS:A1991FN43000004 ER PT J AU GILLIS, PD PARK, OC AF GILLIS, PD PARK, OC TI ARTIFICIAL-INTELLIGENCE AND HUMAN LEARNING - INTELLIGENT COMPUTER-AIDED-INSTRUCTION - SELF,J SO JOURNAL OF COMPUTER-BASED INSTRUCTION LA English DT Book Review RP GILLIS, PD (reprint author), USA,RES INST,ALEXANDRIA,VA, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU ADCIS INT HEADQUARTERS PI COLUMBUS PA 1601 WEST FIFTH AVE, SUITE 111, COLUMBUS, OH 43212 SN 0098-597X J9 J COMPUT-BASE INSTR PD SPR PY 1991 VL 18 IS 2 BP 73 EP 74 PG 2 WC Education & Educational Research SC Education & Educational Research GA FN430 UT WOS:A1991FN43000008 ER PT J AU FEIN, HG BURMAN, KD DJUH, YY USALA, SJ BALE, AE WEINTRAUB, BD SMALLRIDGE, RC AF FEIN, HG BURMAN, KD DJUH, YY USALA, SJ BALE, AE WEINTRAUB, BD SMALLRIDGE, RC TI TIGHT LINKAGE OF THE HUMAN C-ERBA-BETA GENE WITH THE SYNDROME OF GENERALIZED THYROID-HORMONE RESISTANCE IS PRESENT IN MULTIPLE KINDREDS SO JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION LA English DT Article DE THYROID HORMONE RESISTANCE; THYROID HORMONE RECEPTOR; LINKAGE ANALYSIS; RESTRICTION FRAGMENT LENGTH POLYMORPHISMS ID CULTURED SKIN FIBROBLASTS; INAPPROPRIATE SECRETION; NUCLEAR-BINDING; RECEPTOR; TRIIODOTHYRONINE; MUTATION; PROTEIN AB Generalized thyroid hormone resistance recently was reported to map in a single kindred to the same chromosomal region as the c-erbA-beta gene, which codes for a putative thyroid hormone receptor. Restriction fragment length polymorphisms (RFLPs) of c-erbA-beta were linked with GTHR in three kindreds with variable neuropsychologic dysfunction; two unrelated kindreds have been reported to possess different single base mutations in the T3 binding domain of c-erbA-beta. In order to ascertain if tight linkage with c-erbA-beta could be generalized to other families with this syndrome, we performed RFLP analysis in a separate laboratory on an unrelated family with GTHR which lacks the neuropsychologic defects or short stature often associated with GTHR (Kindred WR). RFLPs were identified after Bam HI and Eco RV digestion of DNA from leukocytes from 14 family members. The Bam HI RFLPs were 2.8 and 5.3 kb bands, and the Eco RV RFLPs were 1.6 and 3.3 kb bands. These RFLPs cosegregated with the GTHR phenotype and 11 family members were informative when both RFLPs were employed. The logarithm of the odds ratio between GTHR and c-erbA-beta was 3.67, and therefore GTHR mapped to the c-erbA-beta locus in this kindred. Allelic-specific hybridization with a probe constructed to identify the C to A mutation at nucleotide position 1643 (previously identified in one other kindred) suggested that our family has a different c-erbA-beta abnormality. Although GTHR appears to be commonly associated with alterations in the human c-erbA-beta gene, different kindreds may inherit different genetic defects. C1 WALTER REED ARMY MED CTR,DEPT MED,WASHINGTON,DC 20307. E CAROLINA UNIV,DEPT MED,GREENVILLE,NC 27858. YALE UNIV,DEPT HUMAN GENET,NEW HAVEN,CT 06510. NIADDKD,MOLEC CELLULAR & NUTR ENDOCRINOL BRANCH,BETHESDA,MD 20892. RP FEIN, HG (reprint author), WALTER REED ARMY MED CTR,DEPT CLIN PHYSIOL,WASHINGTON,DC 20307, USA. NR 19 TC 12 Z9 12 U1 0 U2 0 PU EDITRICE KURTIS S R L PI MILANO PA VIA LUIGI ZOJA, 30-20153 MILANO, ITALY SN 0391-4097 J9 J ENDOCRINOL INVEST JI J. Endocrinol. Invest. PD MAR PY 1991 VL 14 IS 3 BP 219 EP 223 PG 5 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA FL247 UT WOS:A1991FL24700009 PM 1677017 ER PT J AU BAUMGARTNER, JC FALKLER, WA AF BAUMGARTNER, JC FALKLER, WA TI DETECTION OF IMMUNOGLOBULINS FROM EXPLANT CULTURES OF PERIAPICAL LESIONS SO JOURNAL OF ENDODONTICS LA English DT Article ID GRANULOMAS; CYSTS AB The presence of immunoreactive cells in periapical inflammatory lesions suggests that immune responses participate in the disease process. The purpose of this study was to determine the presence and concentration of immunoglobulins in the supernatant fluids of explant cultures of periapical lesions. Ninety periapical lesions that had been contiguous with the apex of a root were removed and maintained in explant cultures for 96 h. Tissue culture medium was replenished at 24, 48, 72, and 96 h. Double diffusion in agarose assays demonstrated the presence of IgG in 100% of the 24-h supernatant fluids and IgA in 65% of the 24-h supernatant fluids. However, IgM was not detected. Radial immunodiffusion assays were used to detect and quantitate IgG, IgA, and IgM in samples of 24-h supernatant fluids from 90 explant cultures. IgG was the predominant immunoglobulin followed by IgA. A radioimmunosorbent test was used to detect and quantitate IgE in samples of 24-h supernatant fluids from 90 explant cultures. Forty of the 90 supernatant fluids contained measurable IgE. All detected immunoglobulins decreased in concentration in daily supernatant fluids with time (24, 48, 72, and 96 h) in the culture. C1 WALTER REED ARMY MED CTR,INST DENT RES,MICROBIOL BRANCH,WASHINGTON,DC 20307. UNIV MARYLAND,SCH DENT,DEPT MICROBIOL,COLLEGE PK,MD 20742. NR 17 TC 6 Z9 6 U1 0 U2 2 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0099-2399 J9 J ENDODONT JI J. Endod. PD MAR PY 1991 VL 17 IS 3 BP 105 EP 110 DI 10.1016/S0099-2399(06)81739-5 PG 6 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA EZ662 UT WOS:A1991EZ66200003 PM 1940722 ER PT J AU BAUMGARTNER, JC STANLEY, HR SALOMONE, JL AF BAUMGARTNER, JC STANLEY, HR SALOMONE, JL TI ZEBRA-VI .1. SO JOURNAL OF ENDODONTICS LA English DT Article C1 WALTER REED ARMY MED CTR,INST DENT RES,MICROBIOL BRANCH,WASHINGTON,DC 20307. UNIV FLORIDA,COLL DENT,GAINESVILLE,FL 32611. RADAR DENT CLIN,FT MYERS,VA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0099-2399 J9 J ENDODONT JI J. Endod. PD MAR PY 1991 VL 17 IS 3 BP 135 EP 136 DI 10.1016/S0099-2399(06)81747-4 PG 2 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA EZ662 UT WOS:A1991EZ66200011 ER PT J AU CHOUDHRY, MY AF CHOUDHRY, MY TI COMPARISON OF MINUTE SMEARS OF LIPSTICK BY MICROSPECTROPHOTOMETRY AND SCANNING ELECTRON-MICROSCOPY ENERGY-DISPERSIVE SPECTROSCOPY SO JOURNAL OF FORENSIC SCIENCES LA English DT Article DE FORENSIC SCIENCE; LIPSTICK; MICROSCOPY; SPECTROSCOPIC ANALYSIS; SCANNING ELECTRON MICROSCOPY; BACKSCATTERED ELECTRON IMAGING; X-RAY MICROANALYSIS; MICROSPECTROPHOTOMETRY ID PERFORMANCE LIQUID-CHROMATOGRAPHY AB Minute lipstick smears are sometimes found as evidence on clothing, cigarette butts, bedding, and miscellaneous crime scene surfaces. Traditional techniques, such as visible-absorption spectroscopy, and paper and thin-layer chromatography, are not always suitable for comparison of the trace amounts of lipstick which usually occur in actual casework. Microspectrophotometry and scanning electron microscopy (SEM), in combination with energy-dispersive spectroscopy (EDS) were evaluated for comparison of minute lipstick samples. Microspectrophotometry proved very promising in differentiating lipstick samples of nearly the same color but with minor shade differences. Backscattered electron imaging followed by X-ray microanalysis was used as an additional method for discrimination purposes. Both of these techniques can rapidly analyze microscopic samples of lipstick. RP CHOUDHRY, MY (reprint author), USA,CRIMINAL INVEST LAB,CONUS,FOREST PK,GA 30050, USA. NR 10 TC 12 Z9 12 U1 2 U2 8 PU AMER SOC TESTING MATERIALS PI W CONSHOHOCKEN PA 100 BARR HARBOR DR, W CONSHOHOCKEN, PA 19428-2959 SN 0022-1198 J9 J FORENSIC SCI JI J. Forensic Sci. PD MAR PY 1991 VL 36 IS 2 BP 366 EP 375 PG 10 WC Medicine, Legal SC Legal Medicine GA FJ855 UT WOS:A1991FJ85500012 ER PT J AU DAILEY, JC AF DAILEY, JC TI A PRACTICAL TECHNIQUE FOR THE FABRICATION OF TRANSPARENT BITE MARK OVERLAYS SO JOURNAL OF FORENSIC SCIENCES LA English DT Article DE ODONTOLOGY; BITE MARKS; OVERLAYS AB A quick, inexpensive, and accurate technique for generating transparent overlays, using office photocopy machines, for use in bite mark case analysis is presented. The critical step in the fabrication process involves determination of the accuracy of the product produced by the photocopy machine. A reliable method for making such a determination is discussed. RP DAILEY, JC (reprint author), USA DENT ACT,WILLIAM BEAUMONT ARMY MED CTR,FT BLISS,TX 79920, USA. NR 6 TC 14 Z9 14 U1 1 U2 1 PU AMER SOC TESTING MATERIALS PI W CONSHOHOCKEN PA 100 BARR HARBOR DR, W CONSHOHOCKEN, PA 19428-2959 SN 0022-1198 J9 J FORENSIC SCI JI J. Forensic Sci. PD MAR PY 1991 VL 36 IS 2 BP 565 EP 570 PG 6 WC Medicine, Legal SC Legal Medicine GA FJ855 UT WOS:A1991FJ85500032 PM 2066731 ER PT J AU HORNBACH, DJ DENEKA, T MILLER, AC PAYNE, BS AF HORNBACH, DJ DENEKA, T MILLER, AC PAYNE, BS TI VARIATIONS IN THE RATE OF SEDIMENT ACCUMULATION IN A BACKWATER LAKE, POOL 2, MISSISSIPPI RIVER SO JOURNAL OF FRESHWATER ECOLOGY LA English DT Article ID NAVIGATION POOLS; HABITAT AB The rates of sediment deposition in a backwater lake were examined in the summers of 1987, 1988, and 1989 in River Lake (RM 826). To ascertain the spatial variation in sediment accretion, deposition was measured using PVC tubes (height:diameter ratio, 10:1 = 38.1:3.81 cm). Nine replicates were placed at each of three stations along each of three N/S transects of the lake for two-week periods. These transects were parallel to the flow of the river. In 1987 and 1988 the total dry weight and ash-free dry weight of the accumulated sediment was measured in a subsample of the traps. For 1987-1989, the volume of sediment was also assessed. Significant differences were found among transects and stations in the rates of deposition and in the percent organic matter in the deposited sediment. Temporal variation in sediment accretion in the 10:1 traps was noted with deposition being more pronounced in July and August. Analyses indicate that for the 10:1 traps there was a small negative correlation between sedimentation and mean river discharge and that the sediment accumulation as ash-free dry weight was positively correlated to the percent organic matter in the lake sediment. Deposition rates were highest in 1988, a drought year. To examine trap efficiency, for 6 weeks in 1988 and for 14 weeks in 1989 the sampling regimen was expanded to include 5:1 (15.2:3.81 cm) and 2:1 (15.2:7.62 cm) traps. Trap size had a significant effect upon the rate of sediment accretion. The 2:1 and 5:1 traps tended to give higher rates of sedimentation, probably because they sampled a greater proportion of the water column than the 10:1 traps. The 2:1 traps tend to give higher values than the 5:1 or 10:1 traps when weight (dry or ash-free) was used as a measure of sediment deposition but lower rates when volume was used as a measure of deposition. C1 USA,ENGINEER WATERWAYS EXPT STN,VICKSBURG,MS 39180. RP HORNBACH, DJ (reprint author), MACALESTER COLL,DEPT BIOL,ST PAUL,MN 55105, USA. NR 13 TC 2 Z9 2 U1 0 U2 5 PU OIKOS PUBL INC PI LA CROSSE PA PO BOX 2558, LA CROSSE, WI 54601 SN 0270-5060 J9 J FRESHWATER ECOL JI J. Freshw. Ecol. PD MAR PY 1991 VL 6 IS 1 BP 53 EP 60 DI 10.1080/02705060.1991.9665275 PG 8 WC Ecology; Limnology SC Environmental Sciences & Ecology; Marine & Freshwater Biology GA FJ434 UT WOS:A1991FJ43400006 ER PT J AU OLENICK, JG NAUMAN, RK JETT, M AF OLENICK, JG NAUMAN, RK JETT, M TI STAPHYLOCOCCAL ENTEROTOXIN-B - IMMUNOLABELING AND VISUALIZATION OF TARGET-CELLS SO JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY LA English DT Note DE IMMUNOFLUORESCENCE MICROSCOPY; STAPHYLOCOCCAL ENTEROTOXIN-B; MAST CELLS; LEUKOCYTES; IMMEDIATE HYPERSENSITIVITY ID HUMAN PERIPHERAL LYMPHOCYTES; CYSTEINYL LEUKOTRIENES; UNSENSITIZED MONKEYS; IMMUNE-RESPONSE; MEDIATORS; CHALLENGE; TOXIN; SEB AB Binding of staphylococcal enterotoxin B (SEB) to cultured cells and to tissue sections containing presumed target sites was detected by use of an immunofluorescence sandwich technique. A triple sandwich with successive incubations of SEB, rabbit anti-SEB, and fluorescein-conjugated goat anti-rabbit secondary antibody was applied to samples. Binding of SEB to rat basophilic leukemia (RBL) cells, mast cells of rat dorsal skin, and cells of leukocyte-enriched human plasma was observed. Our results point out and reinforce the reported involvement of SEB in various biological effects that appear to implicate leukocytes, either as mast cells residing in tissues or as white cells circulating in the bloodstream. C1 UNIV MARYLAND,SCH DENT,DEPT MICROBIOL,BALTIMORE,MD 21201. RP OLENICK, JG (reprint author), WALTER REED ARMY MED CTR,DEPT MOLEC PATHOL,WASHINGTON,DC 20307, USA. NR 25 TC 6 Z9 6 U1 0 U2 0 PU HISTOCHEMICAL SOC INC PI NEW YORK PA MT SINAI MEDICAL CENTER 19 EAST 98TH ST SUTIE 9G, NEW YORK, NY 10029 SN 0022-1554 J9 J HISTOCHEM CYTOCHEM JI J. Histochem. Cytochem. PD MAR PY 1991 VL 39 IS 3 BP 373 EP 377 PG 5 WC Cell Biology SC Cell Biology GA EX747 UT WOS:A1991EX74700014 PM 1993831 ER PT J AU WEEKS, DJ REEVE, TG DORNIER, LA FOBER, GW AF WEEKS, DJ REEVE, TG DORNIER, LA FOBER, GW TI INTER-CRITERION INTERVAL ACTIVITY AND THE RETENTION OF MOVEMENT INFORMATION - A TEST OF THE FORGETTING HYPOTHESIS FOR CONTEXTUAL INTERFERENCE EFFECTS SO JOURNAL OF HUMAN MOVEMENT STUDIES LA English DT Article DE CONTEXTUAL INTERFERENCE; MOTOR RETENTION; LINEAR POSITIONING; SPACING EFFECTS ID TERM MOTOR MEMORY; REPETITION; ACQUISITION; SKILL; CUES AB Two experiments evaluated a prediction derived from Lee and Magill's (1985) forgetting hypothesis. That is, forgetting between repetitions of goal-directed actions enhances recall. Although the forgetting hypothesis was developed to account for motor learning phenomena, the potential for cognitively interfering activity to enhance the short-term retention of movement information was considered. The effects of inserting cognitively interfering activity into the inter-criterion interval was examined for extent and location information in Experiments 1 and 2, respectively. Only recall of extent information was shown to benefit from the interfering activity. The implications of the results for studies employing motor-learning paradigms are discussed. C1 AUBURN UNIV,AUBURN,AL 36849. TEXAS TECH UNIV,LUBBOCK,TX 79409. USA,RES INST,WASHINGTON,DC 20310. RP WEEKS, DJ (reprint author), LAKEHEAD UNIV,SCH PHYS EDUC,MOTOR BEHAV LAB,THUNDER BAY P7B 5E1,ONTARIO,CANADA. NR 21 TC 1 Z9 1 U1 2 U2 4 PU TEVIOT-KIMPTON PUBLICATIONS PI EDINBURGH PA 82 GREAT KING STREET, EDINBURGH, MIDLOTHIAN, SCOTLAND EH3 6QU SN 0306-7297 J9 J HUM MOVEMENT STUD JI J. Hum. Movement Stud. PD MAR PY 1991 VL 20 IS 3 BP 101 EP 110 PG 10 WC Psychology, Experimental; Sport Sciences SC Psychology; Sport Sciences GA HE186 UT WOS:A1991HE18600001 ER PT J AU LANDE, RG AF LANDE, RG TI LAW AND THE MENTAL-HEALTH SYSTEM - CIVIL AND CRIMINAL ASPECTS - REISNER,C, SLOBOGIN,C SO JOURNAL OF LEGAL MEDICINE LA English DT Book Review RP LANDE, RG (reprint author), WALTER REED ARMY MED CTR,WASHINGTON,DC 20307, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU TAYLOR & FRANCIS PI BRISTOL PA 1900 FROST ROAD, SUITE 101, BRISTOL, PA 19007-1598 SN 0194-7648 J9 J LEGAL MED JI J. Legal Med. PD MAR PY 1991 VL 12 IS 1 BP 105 EP 110 PG 6 WC Law; Social Sciences, Biomedical SC Government & Law; Biomedical Social Sciences GA FH062 UT WOS:A1991FH06200004 ER PT J AU SCHMITZ, KM JIAO, KL SHARMA, R ANDERSON, WA RAJESWARAN, G ZHENG, LR COLE, MW LAREAU, RT AF SCHMITZ, KM JIAO, KL SHARMA, R ANDERSON, WA RAJESWARAN, G ZHENG, LR COLE, MW LAREAU, RT TI MICROSTRUCTURAL ANALYSIS OF PD-BASED OHMIC CONTACTS TO P-TYPE GAAS SO JOURNAL OF MATERIALS RESEARCH LA English DT Article AB As part of the investigation of the use of Pd-based ohmic contacts to p-type GaAs, cross-sectional transmission electron microscopy, Auger electron spectroscopy, and secondary ion mass spectroscopy were used to explore the uniformity at the metal/GaAs interface and its composition profile after ohmic contact formation. Comparisons were made among Au:Be, Au:Be/Pd, and Au/Pd contacts. Region of p+ were formed in n-type GaAs by a spin-on source which was rapid diffused at 950-degrees-C for 6 s or by ion implantation at a dose of 3 x 10(14) atoms/cm2 at 150 keV for 15 min. Metallizations were accomplished by evaporation with a base pressure of 3 x 10(-6) Torr. Sintering of the metallizations was done in a furnace at 350-degrees-C for 15 min. Cross-sectional transmission electron microscope studies revealed an absence of spiking when Be is present in the metallization scheme but a broad band diffused into GaAs. An improper metal/GaAs adhesion was observed when Pd is absent. Be assists in confining the reaction of Pd with GaAs and acts as a diffusion barrier to the p+ dopant. Electrical measurements, taken from transmission line and cross bridge Kelvin resistors, were best for the Pd/Au:Be, which yielded a contact resistance of 0.3-mu-OMEGA-cm2. C1 EASTMAN KODAK CO, CORP RES LAB, ROCHESTER, NY 14650 USA. USA, ELECTR TECHNOL & DEVICES LAB, FT MONMOUTH, NJ 07703 USA. RP SUNY BUFFALO, DEPT ELECT & COMP ENGN, CTR ELECTR & ELECTROOPT MAT, BUFFALO, NY 14260 USA. NR 8 TC 4 Z9 4 U1 0 U2 1 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA SN 0884-2914 EI 2044-5326 J9 J MATER RES JI J. Mater. Res. PD MAR PY 1991 VL 6 IS 3 BP 553 EP 559 DI 10.1557/JMR.1991.0553 PG 7 WC Materials Science, Multidisciplinary SC Materials Science GA FA769 UT WOS:A1991FA76900016 ER PT J AU LINTHICUM, KJ LOGAN, TM KONDIG, JP GORDON, SW BAILEY, CL AF LINTHICUM, KJ LOGAN, TM KONDIG, JP GORDON, SW BAILEY, CL TI LABORATORY BIOLOGY OF HYALOMMA-TRUNCATUM (ACARI, IXODIDAE) SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE ACARINA; HYALOMMA-TRUNCATUM; LABORATORY BIOLOGY; LIFE CYCLE ID CONGO HEMORRHAGIC-FEVER; LIFE-CYCLE; TICK; OVIPOSITION AB The life cycle of Hyalomma truncatum Koch (Acari:Ixodidae) required an average of 108 d at 26 +/- 1-degrees-C, 92-96% RH, and a 12:12 (L:D) photoperiod to complete. Mean weights of unfed larvae, nymphs, and females were 0.02, 0.19, and 11.1 mg, respectively. Weights of larvae, nymphs, and females increased 20-, 91-, and 48-fold, respectively, as a result of feeding on guinea pigs. All stages exhibited host-seeking behavior < 1 d after emergence. The mean (+/- SE) feeding period of larvae, nymphs, and adults was 3.8 (+/- 0.1), 7.7 (+/- 0.3), and 8.3 (+/- 0.3) d, respectively. Larvae and nymphs molted an average of 11.0 (+/- 0.3) and 30.7 (+/- 0.2) d after engorgement, respectively. The female/male sex ratio, as determined from emerged adults, was 1.4:1. Oviposition started an average of 11.9 (+/- 0.8) d after engorgement, and a mean of 6,701 eggs per female was deposited. A total of only 48% of the eggs eclosed after a mean incubation of 35 (+/- 1.1) d. Females converted 56% of their engorged weight into eggs and produced an average of 12,614 (+/- 2.0) eggs/g of engorged body weight. On the first day of oviposition, an egg < 24 h old weighed an average of 44.8 (+/- 1.5) mu-g. Egg weight was significantly (P < 0.01) lower during peak egg production (days 2-8 after onset of oviposition) than during reduced egg production (days 14-20 after onset of oviposition). RP LINTHICUM, KJ (reprint author), USA,INFECT DIS RES INST,DIV VIROL,DEPT ARBOVIRAL ENTOMOL,FT DETRICK,FREDERICK,MD 21702, USA. RI Gordon, Scott/B-8875-2011 NR 15 TC 12 Z9 13 U1 1 U2 1 PU ENTOMOL SOC AMER PI LANHAM PA 9301 ANNAPOLIS RD, LANHAM, MD 20706 SN 0022-2585 J9 J MED ENTOMOL JI J. Med. Entomol. PD MAR PY 1991 VL 28 IS 2 BP 280 EP 283 PG 4 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA FA263 UT WOS:A1991FA26300017 PM 2056512 ER PT J AU LOGAN, TM LINTHICUM, KJ DAVIES, FG BINEPAL, YS ROBERTS, CR AF LOGAN, TM LINTHICUM, KJ DAVIES, FG BINEPAL, YS ROBERTS, CR TI ISOLATION OF RIFT-VALLEY FEVER VIRUS FROM MOSQUITOS (DIPTERA, CULICIDAE) COLLECTED DURING AN OUTBREAK IN DOMESTIC-ANIMALS IN KENYA SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Note DE INSECTA; CULEX-ZOMBAENSIS; MANSONIA-AFRICANA; RIFT VALLEY FEVER VIRUS ID FIELD AB During an outbreak of Rift Valley fever (RVF) in livestock near Lake Naivasha, Rift Valley Province, Kenya, 61,347 mosquitoes (1,287 pools) collected in CO2-baited light traps yielded seven viral isolates. Five isolates of RVF virus were recovered from 18,831 Culex zombaensis Theobald and one from 14,439 Mansonia africana (Theobald). One isolate of a Bunyamwera group virus was recovered from 1,175 Aedes quasiunivittatus (Theobald). C1 USA,INFECT DIS MED RES INST,FREDERICK,MD 21702. VET RES LABS,KABETE,KENYA. RP LOGAN, TM (reprint author), USA,MED RES UNIT KENYA,BOX 401,APO,NEW YORK,NY 09675, USA. NR 16 TC 42 Z9 43 U1 2 U2 4 PU ENTOMOL SOC AMER PI LANHAM PA 9301 ANNAPOLIS RD, LANHAM, MD 20706 SN 0022-2585 J9 J MED ENTOMOL JI J. Med. Entomol. PD MAR PY 1991 VL 28 IS 2 BP 293 EP 295 PG 3 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA FA263 UT WOS:A1991FA26300021 PM 1676073 ER PT J AU GLASER, CG NAGY, WW AF GLASER, CG NAGY, WW TI RESTORATION OF CANINE DISOCCLUSION BY USING ETCHED PORCELAIN ONLAYS SO JOURNAL OF PROSTHETIC DENTISTRY LA English DT Article C1 USA,DENT ACTIV,DENT CLIN 1,FT DRUM,NY. NR 6 TC 2 Z9 2 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0022-3913 J9 J PROSTHET DENT JI J. Prosthet. Dent. PD MAR PY 1991 VL 65 IS 3 BP 338 EP 340 DI 10.1016/0022-3913(91)90221-H PG 3 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA EZ826 UT WOS:A1991EZ82600003 PM 2056451 ER PT J AU RENDER, PJ JENNINGS, DE AF RENDER, PJ JENNINGS, DE TI PORCELAIN-METAL PONTICS FOR REMOVABLE PARTIAL DENTURES SO JOURNAL OF PROSTHETIC DENTISTRY LA English DT Article AB A custom-made porcelain-fused-to-metal ring pontic for a removable partial denture may be color characterized and glazed by use of familiar procedures. The use of this type of pontic on removable partial dentures has the potential of superior esthetic results when replacing isolated maxillary anterior teeth. C1 USA,PROSTHODONT RESIDENCY PROGRAM,FT SAM HOUSTON,TX 78234. USA,PROSTHODONT CLIN,FT BRAGG,NC. NR 3 TC 1 Z9 1 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0022-3913 J9 J PROSTHET DENT JI J. Prosthet. Dent. PD MAR PY 1991 VL 65 IS 3 BP 452 EP 453 DI 10.1016/0022-3913(91)90242-O PG 2 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA EZ826 UT WOS:A1991EZ82600024 PM 2056469 ER PT J AU NUSCA, MJ AF NUSCA, MJ TI LOW REYNOLDS-NUMBER NAVIER-STOKES SIMULATION FOR ROTATING LIQUID-FILLED CONTAINERS SO JOURNAL OF SPACECRAFT AND ROCKETS LA English DT Article ID VISCOUS-LIQUID AB Three-dimensional, steady, laminar, incompressible Navier-Stokes equations are solved using an implicit finite-difference scheme based on successive over-relaxation. These low Reynolds number numerical simulations are used to predict the behavior of liquids undergoing steady spin and steady precession at a fixed precession angle. Low Reynolds number simulations are applicable to slowly spinning vehicles or highly viscous liquid payloads. The liquid is contained in a fully filled axisymmetric container; the particular geometry examined in this paper is a right-circular cylinder with flat or rounded endcaps. Numerical predictions of viscous and pressure moments due to the liquid fill at low Reynolds number are reported. These moments tend to increase the precession angle and reduce the spin rate of the container. Liquid-induced roll and side (yaw) moments are computed as functions of endcap height to cylinder radius (0 less-than-or-equal-to e/a less-than-or-equal-to 1), cylinder half-height to radius (0.5 less-than-or-equal-to c/a less-than-or-equal-to 4), Reynolds number (20 less-than-or-equal-to Re less-than-or-equal-to 3 x 10(2)), ratio of precession to spin rate (0.05 less-than-or-equal-to tau less-than-or-equal-to 0.95), and precession angle (alpha-c = 2 deg). For a given cylinder, rounded endcaps can decrease the resonant liquid-induced moment by about 20% and shift the resonance to a smaller Reynolds number (for fixed precessional frequency). Thus, rounded endcaps can produce flight stability for some projectiles with highly viscous liquid payloads. RP NUSCA, MJ (reprint author), USA,BALLIST RES LABS,DIV LAUNCH & FLIGHT,ABERDEEN PROVING GROUND,MD 21005, USA. NR 19 TC 0 Z9 0 U1 0 U2 1 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091 SN 0022-4650 J9 J SPACECRAFT ROCKETS JI J. Spacecr. Rockets PD MAR-APR PY 1991 VL 28 IS 2 BP 152 EP 157 DI 10.2514/3.26223 PG 6 WC Engineering, Aerospace SC Engineering GA FT142 UT WOS:A1991FT14200005 ER PT J AU LEMLEY, PV WELCH, MJ AF LEMLEY, PV WELCH, MJ TI A CORRELATION BETWEEN MUSCULAR STRENGTH AND HYDROXYPROLINE CONCENTRATION IN HUMAN PATELLAR TENDON SO JOURNAL OF SPORTS MEDICINE AND PHYSICAL FITNESS LA English DT Article DE HYDROXYPROLINE; CONNECTIVE TISSUE; COLLAGEN AB The connective tissue of the knee is frequently injured by athletes, especially those involved in contact sports. It would be important in the prevention of injury as well as the strategy of physical fitness training to know whether the connective tissue is modified in response to athletic stress or training. The potential modification investigated was variability in the concentration of hydroxyproline, a post-translationally modified imino acid found principally in collagen protein. A correlation was sought between this variability and the leg strength parameters torque (expressed as ft-lbs), torque/body weight and work (expressed as ft-lbs). In a preliminary study of five subjects, no correlation was found between hydroxyproline concentration of the patellar tendon and any of the leg strength parameters. These results suggest that this modification of the collagen in connective tissue does not occur in response to athletic stress or training, but rather, for the small number of subjects investigated, appeared to be relatively constant across a range of leg strengths. RP LEMLEY, PV (reprint author), USA,MED RES INST INFECT DIS,DIV PATHOPHYSIOL,FREDERICK,MD 21701, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU EDIZIONI MINERVA MEDICA PI TURIN PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY SN 0022-4707 J9 J SPORT MED PHYS FIT JI J. Sports Med. Phys. Fit. PD MAR PY 1991 VL 31 IS 1 BP 104 EP 107 PG 4 WC Sport Sciences SC Sport Sciences GA FL604 UT WOS:A1991FL60400016 PM 1861475 ER PT J AU METZ, S AF METZ, S TI EISENHOWER AND THE PLANNING OF AMERICAN GRAND STRATEGY SO JOURNAL OF STRATEGIC STUDIES LA English DT Review RP METZ, S (reprint author), US ARMY COMMAND & GEN STAFF COLL,NATL SECUR AFFAIRS,FT LEAVENWORTH,KS 66027, USA. NR 41 TC 7 Z9 7 U1 0 U2 0 PU FRANK CASS CO LTD PI LONDON PA 11 GAINSBOROUGH ROAD, LONDON, ENGLAND E11 1RS SN 0140-2390 J9 J STRATEGIC STUD JI J. Strateg. Stud. PD MAR PY 1991 VL 14 IS 1 BP 49 EP 71 DI 10.1080/01402399108437439 PG 23 WC International Relations; Political Science SC International Relations; Government & Law GA FU618 UT WOS:A1991FU61800003 ER PT J AU JENSEN, PS RICHTERS, J USSERY, T BLOEDAU, L DAVIS, H AF JENSEN, PS RICHTERS, J USSERY, T BLOEDAU, L DAVIS, H TI CHILD PSYCHOPATHOLOGY AND ENVIRONMENTAL-INFLUENCES - DISCRETE LIFE EVENTS VERSUS ONGOING ADVERSITY SO JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY LA English DT Article DE STRESS; PARENTAL PSYCHOPATHOLOGY; CHILD PSYCHOPATHOLOGY; CHILDRENS SYMPTOMATOLOGY ID ETIOLOGIC FACTORS; STRESS; ADOLESCENCE; DEPRESSION; DISORDERS; DISEASES; BEHAVIOR AB Patterns of exposure to distinct types of life stressors were compared between 134-children attending a military child psychiatric clinic and a matched military community control sample. Compared with the community sample, clinic-referred children had experienced significantly higher levels of normative stressful events as well as events confounded with their own adjustment and events related to parental psychosocial functioning. Differences in levels of normative stressful events were no longer significant, however, when controlling for events related to parental functioning. Ratings of stressful events during the past year significantly underestimated the lifetime stress exposure differences between clinic and community control children. Although normative stressful events, parent-related events, and parent symptomatology ratings were significantly related to child behavior problem ratings, normative stressful events did not contribute to predictions of child behavior problems beyond the variance attributable to parent-related events and parent symptomatology. Implications of these findings for life stress and child maladjustment research are discussed. C1 WALTER REED ARMY MED CTR,DEPT MILITARY PSYCHIAT,WASHINGTON,DC 20307. MED COLL GEORGIA,AUGUSTA,GA 30912. RP JENSEN, PS (reprint author), NIMH,CHILD & ADOLESCENT DISORDERS RES BRANCH,ROOM 10-104,ROCKVILLE,MD 20857, USA. OI Richters, John/0000-0002-6780-1828; Jensen, Peter/0000-0003-2387-0650 NR 42 TC 36 Z9 36 U1 0 U2 2 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0890-8567 J9 J AM ACAD CHILD PSY JI J. Am. Acad. Child Adolesc. Psychiatr. PD MAR PY 1991 VL 30 IS 2 BP 303 EP 309 DI 10.1097/00004583-199103000-00021 PG 7 WC Psychology, Developmental; Pediatrics; Psychiatry SC Psychology; Pediatrics; Psychiatry GA FB921 UT WOS:A1991FB92100021 PM 2016236 ER PT J AU SHELTON, RM AF SHELTON, RM TI PEMPHIGUS FOLIACEUS ASSOCIATED WITH ENALAPRIL SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Note ID CAPTOPRIL C1 BROOKE ARMY MED CTR,DEPT DERMATOL,FT SAM HOUSTON,TX 78234. NR 5 TC 16 Z9 16 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD MAR PY 1991 VL 24 IS 3 BP 503 EP 504 DI 10.1016/S0190-9622(08)80079-5 PG 2 WC Dermatology SC Dermatology GA EZ742 UT WOS:A1991EZ74200027 PM 2061454 ER PT J AU MCCOLLOUGH, ML GRIMWOOD, RE GRABSKI, WJ AF MCCOLLOUGH, ML GRIMWOOD, RE GRABSKI, WJ TI DOMINANT DYSTROPHIC EPIDERMOLYSIS-BULLOSA WITH INTRAEPIDERMAL TYPE-VII COLLAGEN SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY LA English DT Letter C1 WILFORD HALL USAF MED CTR,SAN ANTONIO,TX. RP MCCOLLOUGH, ML (reprint author), BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234, USA. NR 1 TC 5 Z9 5 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0190-9622 J9 J AM ACAD DERMATOL JI J. Am. Acad. Dermatol. PD MAR PY 1991 VL 24 IS 3 BP 512 EP 512 DI 10.1016/S0190-9622(08)80088-6 PG 1 WC Dermatology SC Dermatology GA EZ742 UT WOS:A1991EZ74200036 PM 2061461 ER PT J AU MAGNON, GJ ROBERT, LL KLINE, DL ROBERTS, LW AF MAGNON, GJ ROBERT, LL KLINE, DL ROBERTS, LW TI REPELLENCY OF 2 DEET FORMULATIONS AND AVON SKIN-SO-SOFT AGAINST BITING MIDGES (DIPTERA, CERATOPOGONIDAE) IN HONDURAS SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Article ID CULICOIDES; JACKET AB Two U.S. military issue deet repellent formulations (75% deet liquid and 33% deet lotion) and Avon Skin-So-Soft(R) were tested against ceratopogonid midges under field conditions in Honduras. Test subjects were U.S. military personnel deployed to Honduras for training. Culicoides furens accounted for 96.3% of all midges collected. The liquid and lotion formulations of deet and Avon Skin-So-Soft provided 97.9, 95.9 and 71.4% protection, respectively, compared with the untreated control. Both deet formulations provided significantly better protection (P < 0.05) than Avon Skin-So-Soft. The latter provided protection by trapping the midges in the oily film and not by repelling the insects as did the deet formulations. C1 WALTER REED ARMY MED CTR,DEPT ENTOMOL,WASHINGTON,DC 20307. USDA ARS,MED & VET ENTOMOL RES LAB,GAINESVILLE,FL 32604. NR 10 TC 14 Z9 15 U1 0 U2 4 PU AMER MOSQUITO CONTROL ASSN INC PI LAKE CHARLES PA 707-A EAST PRIEN LAKE ROAD, PO BOX 5416, LAKE CHARLES, LA 70606-5416 SN 8756-971X J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD MAR PY 1991 VL 7 IS 1 BP 80 EP 82 PG 3 WC Entomology SC Entomology GA FG768 UT WOS:A1991FG76800016 PM 2045813 ER PT J AU LOGAN, TM LINTHICUM, KJ THANDE, PC WAGATEH, JN NELSON, GO ROBERTS, CR AF LOGAN, TM LINTHICUM, KJ THANDE, PC WAGATEH, JN NELSON, GO ROBERTS, CR TI EGG HATCHING OF AEDES-MOSQUITOS DURING SUCCESSIVE FLOODINGS IN A RIFT-VALLEY FEVER ENDEMIC AREA IN KENYA SO JOURNAL OF THE AMERICAN MOSQUITO CONTROL ASSOCIATION LA English DT Note AB Floodwater Aedes breeding habitats in central Kenya were sequentially flooded to determine the numbers of mosquito eggs hatching during each flooding. Approximately 90% of the larvae sampled during 4 floodings emerged during the initial flooding. The number of Aedes eggs hatching during the second flooding was lowest of all 4 floodings, and no significant differences in the amount of egg hatching during floodings 3 and 4 were seen. Unhatched Aedes eggs were present in soil samples collected after the final flooding. The possible implications of these findings with regard to Rift Valley fever virus control are discussed. RP LOGAN, TM (reprint author), USA,MED RES UNIT KENYA,BOX 401,APO,NEW YORK,NY 09675, USA. NR 11 TC 14 Z9 15 U1 0 U2 4 PU AMER MOSQUITO CONTROL ASSN INC PI LAKE CHARLES PA 707-A EAST PRIEN LAKE ROAD, PO BOX 5416, LAKE CHARLES, LA 70606-5416 SN 8756-971X J9 J AM MOSQUITO CONTR JI J. Am. Mosq. Control Assoc. PD MAR PY 1991 VL 7 IS 1 BP 109 EP 112 PG 4 WC Entomology SC Entomology GA FG768 UT WOS:A1991FG76800022 PM 2045800 ER PT J AU LIPP, LJ AF LIPP, LJ TI DESIGN CONSIDERATION OF EXPANDER HEADS FOR VIBRATION SYSTEMS .1. NATURAL FREQUENCY EQUATIONS FOR SQUARE, CONSTANT THICKNESS EXPANDER HEADS SO JOURNAL OF THE IES LA English DT Article DE EXPANDER HEAD; VIBRATION TEST FIXTURE; TEST FIXTURE RESONANCE; TEST FIXTURE DAMPING AB Vibration testing, particularly when performed in reliability test chambers, is very costly. Design considerations for vibration expander heads that will accept several test specimens for simultaneous testing are discussed in this report. Well-designed expander heads will provide more meaningful results and reduce test time and costs through maximum utilization of test hardware. This article, the first of a three-part series, discusses natural frequency equations for square, constant thickness expander heads. Parts II and III will cover damping equations for square, constant thickness expander heads and the inverted truncated pyramid expander head. Complete derivations accompany each expander head equation. RP LIPP, LJ (reprint author), USA,ARMAMENT MUNIT & CHEM COMMAND,ABERDEEN PROVING GROUND,MD 21010, USA. NR 0 TC 0 Z9 0 U1 2 U2 2 PU INST ENVIRONMENTAL SCI PI MT PROSPECT PA 940 E NORTHWEST HIGHWAY, MT PROSPECT, IL 60056 SN 1052-2883 J9 J IES JI J. IES PD MAR-APR PY 1991 VL 34 IS 2 BP 45 EP 55 PG 11 WC Engineering, Environmental; Environmental Sciences; Instruments & Instrumentation SC Engineering; Environmental Sciences & Ecology; Instruments & Instrumentation GA FJ726 UT WOS:A1991FJ72600004 ER PT J AU FRANCESCONI, RP HUBBARD, RW LEVA, NM ANDERSON, RC GOWENLOCK, L AF FRANCESCONI, RP HUBBARD, RW LEVA, NM ANDERSON, RC GOWENLOCK, L TI POTASSIUM-DEFICIENCY IN RATS - EFFECTS ON ACUTE THERMAL TOLERANCE SO JOURNAL OF THERMAL BIOLOGY LA English DT Article DE INDEXES OF HEAT INJURY; HEAT STRESS; HYPERTHERMIA ID FLUID REPLACEMENT; HEAT EXPOSURE; WORK; EXERCISE; HEATSTROKE; ABILITY; MODEL; CHLORPROMAZINE; HYPERTHERMIA; RESPONSES AB 1. Three groups (N = 12/group) of rats (475 g) were fed a nutritionally complete (C), potassium-deficient (-K), or potassium-supplemented (+K) diet for 14 days, followed by passive exposure (unrestrained) to heat stress (41.5-degrees-C) until core temperature reached 42.5-42.6-degrees-C. 2. Circulating K+ levels were significantly (P < 0.01) reduced in the -K group before and after exposure to the severe heat stress. 3. Mean thermal tolerance was 178 min for the C and 149 min for the +K groups (P = NS), but was significantly (P < 0.01) reduced in the -K group (86 min). 4. Despite similar rates of water loss (0.20, 0.18, 0.17 g/min, respectively), rates of heat gain were significantly different among the 3 groups (0.024, 0.032, 0.055-degrees-C/min, P < 0.01). 5. These results suggest that factors other than evaporative heat dissipation, perhaps metabolic heat production, may be contributing to the decreased thermal tolerance in the -K group. RP FRANCESCONI, RP (reprint author), USA,ENVIRONM MED RES INST,DIV HEAT RES,NATICK,MA 01760, USA. NR 29 TC 4 Z9 4 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0306-4565 J9 J THERM BIOL JI J. Therm. Biol. PD MAR PY 1991 VL 16 IS 2 BP 77 EP 82 DI 10.1016/0306-4565(91)90002-J PG 6 WC Biology; Zoology SC Life Sciences & Biomedicine - Other Topics; Zoology GA FC282 UT WOS:A1991FC28200002 ER PT J AU MICHAEL, NL MORROW, P MOSCA, J VAHEY, M BURKE, DS REDFIELD, RR AF MICHAEL, NL MORROW, P MOSCA, J VAHEY, M BURKE, DS REDFIELD, RR TI INDUCTION OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 EXPRESSION IN CHRONICALLY INFECTED-CELLS IS ASSOCIATED PRIMARILY WITH A SHIFT IN RNA SPLICING PATTERNS SO JOURNAL OF VIROLOGY LA English DT Article ID LONG TERMINAL REPEAT; NF-KAPPA-B; TUMOR NECROSIS FACTOR; VIRAL MESSENGER-RNA; REV GENE-PRODUCT; HTLV-III; T-CELLS; HIV-1; ACTIVATION; SEQUENCE AB We have analyzed the kinetics of human immunodeficiency virus type 1 (HIV-1) RNA induction in chronically infected T cells and promonocytes. A substantial amount of spliced mRNAs and assembled virions was found in resting cells. Induction increased the steady-state level of total HIV-1 RNA by 4-fold but increased the level of unspliced transcripts by 25-fold. This increase in unspliced RNA was reflected in the amount of virus seen by electron microscopy. These data suggest a mechanism for the induction of HIV-1 RNA in chronically infected cells involving a shift in splicing greatly favoring the stability of unspliced viral RNA with only a modest increase in total viral RNA. Analysis of the relative abundance of transcript classes is critical to the measurement of HIV-1 viral replication kinetics. C1 WALTER REED ARMY MED CTR,DIV RETROVIROL,WASHINGTON,DC 20307. SRA TECHNOL,ROCKVILLE,MD 20850. HENRY M JACKSON FDN,ROCKVILLE,MD 20850. RP MICHAEL, NL (reprint author), WALTER REED ARMY MED CTR,DEPT RETROVIRAL RES,13 TAFT COURT SUITE 200,WASHINGTON,DC 20307, USA. NR 41 TC 78 Z9 78 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0022-538X J9 J VIROL JI J. Virol. PD MAR PY 1991 VL 65 IS 3 BP 1291 EP 1303 PG 13 WC Virology SC Virology GA EY750 UT WOS:A1991EY75000028 PM 1995944 ER PT J AU HOLMAN, RA LIPPMANN, TC ONEILL, PV HATHAWAY, K AF HOLMAN, RA LIPPMANN, TC ONEILL, PV HATHAWAY, K TI VIDEO ESTIMATION OF SUBAERIAL BEACH PROFILES SO MARINE GEOLOGY LA English DT Article AB A technique is presented that allows estimation of the subaerial beach profile using video imagery. Using either a shadow from a pole or the light from a narrow slit, a line can be "drawn" across the beach at a known origin and angle. When viewed from the longshore direction, the line will appear as a visible beach profile that can be digitized from the image and the ground coordinates of the profile uniquely determined. The theoretical pixel vertical footprint is about one thousandth of the range from the camera, or, for a typical camera, about 10 cm at the 100 m range. Accuracies can be up to +/- 1/2 pixel, or +/- 5 cm at this range. A field test, using a fire hose as a proxy for the shadow, proved the technique, with an average accuracy of +/- 68% of the theoretical footprint size being found. The success of this technique suggests that profile data may be routinely collected using an automated system without the need for a survey team, thus allowing the ready collection of long time series for climatological studies. C1 USA,CORPS ENGINEERS,WATERWAYS EXPT STN,COASTAL ENGN RES CTR FIELD RES FACIL,KITTY HAWK,NC 27949. RP HOLMAN, RA (reprint author), OREGON STATE UNIV,COLL OCEANOG,ADM BLDG 104,CORVALLIS,OR 97331, USA. NR 5 TC 31 Z9 31 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0025-3227 J9 MAR GEOL JI Mar. Geol. PD MAR PY 1991 VL 97 IS 1-2 BP 225 EP 231 DI 10.1016/0025-3227(91)90028-3 PG 7 WC Geosciences, Multidisciplinary; Oceanography SC Geology; Oceanography GA FJ676 UT WOS:A1991FJ67600012 ER PT J AU BEATTY, JH SHIFLET, GJ AF BEATTY, JH SHIFLET, GJ TI STRAIN DISTRIBUTION EFFECTS ON THE LOW-CYCLE FATIGUE BEHAVIOR OF FE-C-MO STEELS SO METALLURGICAL TRANSACTIONS A-PHYSICAL METALLURGY AND MATERIALS SCIENCE LA English DT Article ID DUAL-PHASE STEELS; TI-MN ALLOYS; CARBON-STEEL; STRESS; PRECIPITATION; AUSTENITE AB The strain distributions obtained from monotonic finite element method (FEM) calculations have been employed to model the low-cycle fatigue (LCF) behavior of Fe-C-Mo dual-phase steels. The microstructures considered have a continuous ferrite matrix (with Mo2C precipitates) surrounding martensite packets. Two microstructural parameters have been controlled: (1) the volume fraction of martensite and (2) the strength of the ferrite matrix. The FEM approximations show that highly strained regions dominate LCF lifetimes. The experimentally observed reductions in plastic strain life for increasing martensite volume fractions are described using M-epsilon, the strain magnification factor, which is obtained from the FEM analyses. Strengthening the ferrite matrix or reducing the volume fraction of martensite reduces M-epsilon. The cyclic softening observed is qualitatively correlated with FEM predictions of increasing plastic strain in the martensite as the ferrite strength increases. The overall cyclic hardening-softening behavior results from the combination of ferritic hardening combined with martensitic softening. C1 UNIV VIRGINIA, DEPT MAT SCI, CHARLOTTESVILLE, VA 22901 USA. RP USA, MAT TECHNOL LAB, WATERTOWN, MA 02172 USA. NR 25 TC 5 Z9 5 U1 0 U2 3 PU MINERALS METALS MATERIALS SOC PI WARRENDALE PA 184 THORN HILL RD, WARRENDALE, PA 15086 USA SN 0360-2133 J9 METALL TRANS A PD MAR PY 1991 VL 22 IS 3 BP 675 EP 683 DI 10.1007/BF02670290 PG 9 WC Materials Science, Multidisciplinary SC Materials Science GA EZ837 UT WOS:A1991EZ83700011 ER PT J AU WELKOS, SL AF WELKOS, SL TI PLASMID-ASSOCIATED VIRULENCE FACTORS OF NONTOXIGENIC (PX01-) BACILLUS-ANTHRACIS SO MICROBIAL PATHOGENESIS LA English DT Article DE NONTOXIGENIC BACILLUS-ANTHRACIS; PX02; PLASMID; POLY-D-GLUTAMIC ACID CAPSULE; TRANSPOSON MUTAGENESIS; MOUSE ID PROTECTIVE ANTIGEN GENE; STREPTOCOCCUS-FAECALIS; INSERTIONAL MUTAGENESIS; TRANSPOSON TN917; CAPSULE PLASMID; TOXIN; ENCAPSULATION; SUBTILIS; CLONING; THURINGIENSIS RP WELKOS, SL (reprint author), USA,MED RES INST INFECT DIS,DIV BACTERIOL,FREDERICK,MD 21702, USA. NR 45 TC 72 Z9 76 U1 1 U2 6 PU ACADEMIC PRESS LTD PI LONDON PA 24-28 OVAL RD, LONDON, ENGLAND NW1 7DX SN 0882-4010 J9 MICROB PATHOGENESIS JI Microb. Pathog. PD MAR PY 1991 VL 10 IS 3 BP 183 EP 198 DI 10.1016/0882-4010(91)90053-D PG 16 WC Immunology; Microbiology SC Immunology; Microbiology GA FU409 UT WOS:A1991FU40900002 PM 1654495 ER PT J AU OU, JT BARON, LS AF OU, JT BARON, LS TI STRAIN DIFFERENCES IN EXPRESSION OF VIRULENCE BY THE 90 KILOBASE PAIR VIRULENCE PLASMID OF SALMONELLA SEROVAR TYPHIMURIUM SO MICROBIAL PATHOGENESIS LA English DT Note DE TYPHIMURIUM; VIRULENCE PLASMID; VIRULENCE EXPRESSION; STRAIN DIFFERENCES; TN5 TAGGING; MOUSE TEST ID INSERTION MUTAGENESIS; LOCALIZATION; DETERMINANTS; RESISTANCE; SEQUENCES; CLONING; REGION; GENES C1 WALTER REED ARMY MED CTR,DEPT BACTERIAL IMMUNOL,WASHINGTON,DC 20307. RP OU, JT (reprint author), CHANG GUNG MED COLL,DEPT MICROBIOL & IMMUNOL,TAOYUAN,TAIWAN. NR 25 TC 20 Z9 20 U1 0 U2 0 PU ACADEMIC PRESS LTD PI LONDON PA 24-28 OVAL RD, LONDON, ENGLAND NW1 7DX SN 0882-4010 J9 MICROB PATHOGENESIS JI Microb. Pathog. PD MAR PY 1991 VL 10 IS 3 BP 247 EP 251 DI 10.1016/0882-4010(91)90058-I PG 5 WC Immunology; Microbiology SC Immunology; Microbiology GA FU409 UT WOS:A1991FU40900007 PM 1654496 ER PT J AU CONNOR, MJ AF CONNOR, MJ TI RESOLVING CHILD-SUPPORT ISSUES BEYOND THE SCOPE OF AR 608-99 SO MILITARY LAW REVIEW LA English DT Article RP CONNOR, MJ (reprint author), USA,JUDGE ADVOCATE GEN SCH,DIV ADM & CIVIL LAW,CHARLOTTESVILLE,VA 22901, USA. NR 14 TC 2 Z9 2 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD SPR PY 1991 VL 132 BP 67 EP 97 PG 31 WC Law SC Government & Law GA FR094 UT WOS:A1991FR09400004 ER PT J AU POTTORFF, JP AF POTTORFF, JP TI CONTEMPORARY APPLICATIONS OF THE SOLDIERS AND SAILORS CIVIL RELIEF ACT SO MILITARY LAW REVIEW LA English DT Article RP POTTORFF, JP (reprint author), USA,JUDGE ADVOCATE GEN SCH,DIV & CIVIL LAW,CHARLOTTESVILLE,VA 22901, USA. NR 7 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD SPR PY 1991 VL 132 BP 115 EP 140 PG 26 WC Law SC Government & Law GA FR094 UT WOS:A1991FR09400006 ER PT J AU INGOLD, BP DUNLAP, ML AF INGOLD, BP DUNLAP, ML TI WHEN JOHNNY (JOANNY) COMES MARCHING HOME - JOB SECURITY FOR THE RETURNING SERVICE MEMBER UNDER THE VETERANS REEMPLOYMENT RIGHTS ACT SO MILITARY LAW REVIEW LA English DT Article C1 USN,AIR STN,FALLEN,NV. RP INGOLD, BP (reprint author), USA,JUDGE ADVOCATE GEN SCH,DIV ADM & CIVIL LAW,CHARLOTTESVILLE,VA 22901, USA. NR 9 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD SPR PY 1991 VL 132 BP 175 EP 202 PG 28 WC Law SC Government & Law GA FR094 UT WOS:A1991FR09400008 ER PT J AU INGOLD, BP AF INGOLD, BP TI THE DEPARTMENT OF VETERANS AFFAIRS HOME LOAN GUARANTY PROGRAM - FRIEND OR FOE SO MILITARY LAW REVIEW LA English DT Article RP INGOLD, BP (reprint author), USA,JUDGE ADVOCATE GEN SCH,DIV ADM & CIVIL LAW,CHARLOTTESVILLE,VA 22901, USA. NR 21 TC 1 Z9 1 U1 0 U2 2 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD SPR PY 1991 VL 132 BP 231 EP 264 PG 34 WC Law SC Government & Law GA FR094 UT WOS:A1991FR09400010 ER PT J AU MULLIKEN, SK AF MULLIKEN, SK TI WHEN DOES THE SELLER OWE THE BROKER A COMMISSION - A DISCUSSION OF THE LAW AND WHAT IT TEACHES ABOUT LISTING AGREEMENTS SO MILITARY LAW REVIEW LA English DT Article RP MULLIKEN, SK (reprint author), USA,JUDGE ADVOCATE GEN SCH,DIV ADM & CIVIL LAW,CHARLOTTESVILLE,VA 22901, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU JUDGE ADVOCATE GENERALS SCHOOL PI CHARLOTTESVILLE PA US ARMY, CHARLOTTESVILLE, VA 22903-1781 SN 0026-4040 J9 MIL LAW REV JI Milit. Law Rev. PD SPR PY 1991 VL 132 BP 265 EP 287 PG 23 WC Law SC Government & Law GA FR094 UT WOS:A1991FR09400011 ER PT J AU COTTER, F LAPIANA, FG AF COTTER, F LAPIANA, FG TI EYE CASUALTY REDUCTION BY EYE ARMOR SO MILITARY MEDICINE LA English DT Article AB The wearing of 2-mm thick polycarbonate eye armor would have prevented 39% (49 of 126) of the eye injuries included in the cases of injuries sustained by our forces in Vietnam collected by the Wound Data and Munitions Effectiveness Team. RP COTTER, F (reprint author), WALTER REED ARMY MED CTR,DEPT SURG,OPHTHALMOL SERV,WASHINGTON,DC 20307, USA. NR 0 TC 19 Z9 19 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAR PY 1991 VL 156 IS 3 BP 126 EP 128 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA FB001 UT WOS:A1991FB00100007 PM 1901973 ER PT J AU SMITH, GP AF SMITH, GP TI FORMULA FOR SUCCESS - THE ROLE OF THE MSC OFFICER AND THE UNITED-STATES-ARMY DENTAL-CARE SYSTEM SO MILITARY MEDICINE LA English DT Article AB The Army dental care system has seen significant improvements since the Dental Reform Bill of 1977-1978. This bill initiated changes that improved the management and the productivity of the dental care system. Among the many improvements initiated by these reforms was the addition of a Medical Service Corps (MSC) officer as the executive officer. This has been most noteworthy in the successful management of Dental Activities (DENTAC) and Area Dental Labs on Army installations. The job of DENTAC executive officer has become very prestigious and one of the best assignments an MSC officer can receive during his military career. The alliance between the Dental Corps and the MSC officer has been highly successful and rewarding to both parties. The object of this paper is threefold: (a) to review how the dental organization operated before the Reform Bill; (b) to discuss the present role of the dental Executive Officer; and (c) to provide recommendations for the future role of the MSC officer within the Dental Corps. RP SMITH, GP (reprint author), USA,DENT ACTIV,FT BENNING,GA 31905, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD MAR PY 1991 VL 156 IS 3 BP 134 EP 136 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA FB001 UT WOS:A1991FB00100010 PM 1901975 ER PT J AU CHAMBERS, JP HARTGRAVES, SL MURPHY, MR WAYNER, MJ KUMAR, N VALDES, JJ AF CHAMBERS, JP HARTGRAVES, SL MURPHY, MR WAYNER, MJ KUMAR, N VALDES, JJ TI EFFECTS OF 3 REPUTED CARBOXYLESTERASE INHIBITORS UPON RAT SERUM ESTERASE-ACTIVITY SO NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS LA English DT Article; Proceedings Paper CT SYMP ON ANIMAL-TO-HUMAN EXTRAPOLATION : ISSUES AND OPPORTUNITIES CY MAR 13-15, 1990 CL SAN ANTONIO, TX SP UNIV TEXAS SAN ANTONIO, COLL SCI & ENGN, DIV LIFE SCI, USAF, DIV HUMAN SYST, MED READINESS ADV DEV OFF, USAF, SCH AEROSP MED, DIV RADIAT SCI, SYST RES LAB, USN, MED RES & DEV COMMAND DE ESTERASE; CARBOXYLESTERASE; ORGANOPHOSPHATES; PARANITROPHENYL; NAPHTHYL; CARBOXYLESTERASE INHIBITORS ID LIVER ESTERASE; PIG-LIVER; IDENTIFICATION; ENZYME; FORMS AB Rats have very high endogenous levels of serum carboxylesterase (CAE) compared to primates. This difference accounts for the lower sensitivity of rats to toxic organophosphates, which interact with CAE instead of the more critical acetylcholinesterase. Pretreatment of rats with CAE inhibitors potentiates the effects of organophosphates. In this study, the effects of three putative CAE inhibitors, 2-(o-Cresyl)-4H-1:3:2-benzodioxaphosphorin-2-oxide (CBDP), bis-p-nitrophenyl-phosphate (BNPP), and tetraisopropyl pyrophosphoramide (Iso-OMPA), on the hydrolysis of several commercially available substrates were determined. Respective kinetic constants K(m) and V(max) were derived and effects of inhibitors compared using saturating amounts of substrate. Data presented here indicate significant differences in substrate affinity (K(m)), reactivity (V(max)), as well as effects of inhibitors. CBDP inhibits hydrolysis of specific naphthyl and paranitrophenyl esters at relatively low concentrations (1-10-mu-M). In contrast, significantly higher concentrations (mM) of BNPP and Iso-OMPA were required for inhibition of serum esterase activity. Of the inhibitors tested, Iso-OMPA in general exhibited the smallest inhibitory effect on ester hydrolysis. Although inhibition of hydrolysis of specific paranitrophenyl and naphthyl esters occurred in the presence of similar amounts of CBDP, the degree of inhibition differed significantly (50-75% vs. > 90%, respectively). These data suggest that there exists in rat serum, a pool of naphthyl ester esterase activity that is very sensitive ex vivo (> 90% inhibition) to CBDP and may be very useful in validating a rodent model for soman toxicity. C1 USA,CTR CHEM RES DEV & ENGN,DIV BIOTECHNOL,ABERDEEN PROVING GROUND,MD 21010. USAF,SCH AEROSP MED,BROOKS AFB,TX 78235. RP CHAMBERS, JP (reprint author), UNIV TEXAS,BRAIN RES LAB BIOCHEM,SAN ANTONIO,TX 78285, USA. FU NIGMS NIH HHS [GM07717] NR 17 TC 6 Z9 7 U1 0 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0149-7634 J9 NEUROSCI BIOBEHAV R JI Neurosci. Biobehav. Rev. PD SPR PY 1991 VL 15 IS 1 BP 85 EP 88 DI 10.1016/S0149-7634(05)80096-X PG 4 WC Behavioral Sciences; Neurosciences SC Behavioral Sciences; Neurosciences & Neurology GA FC484 UT WOS:A1991FC48400014 PM 2052204 ER PT J AU MCCARTHY, JF GARDNER, H WOLFE, MJ SHUGART, LR AF MCCARTHY, JF GARDNER, H WOLFE, MJ SHUGART, LR TI DNA ALTERATIONS AND ENZYME-ACTIVITIES IN JAPANESE MEDAKA (ORYZIAS-LATIPES) EXPOSED TO DIETHYLNITROSAMINE SO NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS LA English DT Article; Proceedings Paper CT SYMP ON ANIMAL-TO-HUMAN EXTRAPOLATION : ISSUES AND OPPORTUNITIES CY MAR 13-15, 1990 CL SAN ANTONIO, TX SP UNIV TEXAS SAN ANTONIO, COLL SCI & ENGN, DIV LIFE SCI, USAF, DIV HUMAN SYST, MED READINESS ADV DEV OFF, USAF, SCH AEROSP MED, DIV RADIAT SCI, SYST RES LAB, USN, MED RES & DEV COMMAND DE MEDAKA; GENOTOXICITY; DNA ALTERATIONS; DETOXIFYING ACTIVITIES; DNA STRAND BREAKS; 5'-METHYLDEOXYCYTIDINE; FLOW CYTOMETERY; DIETHYLNITROSAMINE ID QUANTITATION; ASSAY AB Several molecular and biochemical markers of genotoxicity were adapted for measurement in the medaka, and were used to describe the effects of treatment of the organism with diethylnitrosamine (DEN). DEN treatment inhibited the activity of a detoxication enzyme activity (ethoxyresorufin-O-deethylase) and increased the activity of glutathione-S-transferase. This pattern of response has been described in preneoplastic rodent cells. No O6-ethyl guanine adducts were detected, and a slight, but statistically significant, increase in DNA strand breaks was observed. These results are consistent with the hypothesis that prolonged exposure to high levels of DEN induced alkyltransferase activity which enzymatically removes any O6-ethyl guanine adducts but does not result in strand breaks or hypomethylation of the DNA such as might be expected from excision repair of chemically modified DNA. C1 USA,BIOMED RES & DEV LAB,DIV HLTH EFFECTS RES,FT DETRICK,MD 21701. EXPTL PATHOL LABS INC,HERNDON,VA 22070. RP MCCARTHY, JF (reprint author), OAK RIDGE NATL LAB,DIV ENVIRONM SCI,POB 2008-6036,OAK RIDGE,TN 37831, USA. NR 15 TC 6 Z9 7 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0149-7634 J9 NEUROSCI BIOBEHAV R JI Neurosci. Biobehav. Rev. PD SPR PY 1991 VL 15 IS 1 BP 99 EP 102 DI 10.1016/S0149-7634(05)80099-5 PG 4 WC Behavioral Sciences; Neurosciences SC Behavioral Sciences; Neurosciences & Neurology GA FC484 UT WOS:A1991FC48400017 PM 2052206 ER PT J AU DOCTOR, BP RAVEH, L WOLFE, AD MAXWELL, DM ASHANI, Y AF DOCTOR, BP RAVEH, L WOLFE, AD MAXWELL, DM ASHANI, Y TI ENZYMES AS PRETREATMENT DRUGS FOR ORGANOPHOSPHATE TOXICITY SO NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS LA English DT Article; Proceedings Paper CT SYMP ON ANIMAL-TO-HUMAN EXTRAPOLATION : ISSUES AND OPPORTUNITIES CY MAR 13-15, 1990 CL SAN ANTONIO, TX SP UNIV TEXAS SAN ANTONIO, COLL SCI & ENGN, DIV LIFE SCI, USAF, DIV HUMAN SYST, MED READINESS ADV DEV OFF, USAF, SCH AEROSP MED, DIV RADIAT SCI, SYST RES LAB, USN, MED RES & DEV COMMAND DE ACETYLCHOLINESTERASE; ORGANOPHOSPHATE TOXICITY; ENZYMES AS PRETREATMENT DRUGS; SOMAN; SCAVENGER; ESTERASE; BUTYRYLCHOLINESTERASE; CARBOXYLESTERASE; VX; MEPQ ID FETAL BOVINE SERUM; ACETYLCHOLINESTERASE PROPHYLAXIS; BRAIN BARRIER; BLOOD; PURIFICATION; MICE AB We have successfully demonstrated that exogenously administered acetyl- or butyrylcholinesterase (AChE, BChE respectively) will sequester organophosphates (OPs) before they reach their physiological targets. In addition, a third enzyme, endogenous carboxylesterase is known to be capable of scavenging OPs. In these studies, we have administered AChE and BChE to three different species of animals (mice, marmosets and monkeys) which were challenged with three different OPs (VX, MEPQ and soman). Results obtained from these systematic studies demonstrate that: (a) a quantitative linear correlation exists between blood AChE levels and the protection afforded by exogenously administered ChEs in animals challenged with OP, (b) approximately one mole of either AChE or BChE sequesters one mole of OP, (c) such prophylactic measures are sufficient to protect animals against OPs without the administration of any supportive drugs. Thus the OP dose, the blood-level of esterase, the ratio of the circulating enzyme to OP challenge, and the rate of reaction between them determine the overall efficacy of an enzyme as a pretreatment drug. The biochemical mechanism underlying the sequestration of various OPs by the use of exogenously administered scavenging esterases is the same in all species of animals studied. Therefore, the extrapolation of the results obtained by the use of ChE prophylaxis in animals to humans should be more reliable and effective than extrapolating the results from currently used multidrug antidotal modalities. C1 USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010. ISRAEL INST BIOL RES,IL-70450 NESS ZIONA,ISRAEL. RP DOCTOR, BP (reprint author), WALTER REED ARMY MED CTR,DIV BIOCHEM,WASHINGTON,DC 20307, USA. NR 18 TC 87 Z9 89 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0149-7634 J9 NEUROSCI BIOBEHAV R JI Neurosci. Biobehav. Rev. PD SPR PY 1991 VL 15 IS 1 BP 123 EP 128 DI 10.1016/S0149-7634(05)80103-4 PG 6 WC Behavioral Sciences; Neurosciences SC Behavioral Sciences; Neurosciences & Neurology GA FC484 UT WOS:A1991FC48400021 PM 2052184 ER PT J AU MAXWELL, DM BRECHT, KM AF MAXWELL, DM BRECHT, KM TI THE ROLE OF CARBOXYLESTERASE IN SPECIES VARIATION OF OXIME PROTECTION AGAINST SOMAN SO NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS LA English DT Article; Proceedings Paper CT SYMP ON ANIMAL-TO-HUMAN EXTRAPOLATION : ISSUES AND OPPORTUNITIES CY MAR 13-15, 1990 CL SAN ANTONIO, TX SP UNIV TEXAS SAN ANTONIO, COLL SCI & ENGN, DIV LIFE SCI, USAF, DIV HUMAN SYST, MED READINESS ADV DEV OFF, USAF, SCH AEROSP MED, DIV RADIAT SCI, SYST RES LAB, USN, MED RES & DEV COMMAND DE OXIME PROTECTION; SOMAN; CARBOXYLESTERASE; SPECIES VARIATION ID INCLUDING MAN; GUINEA-PIG; HI-6; INHIBITION; TABUN; CHOLINESTERASE; REACTIVATION; RAT; PHARMACOKINETICS; PRIMATES AB Oxime protection against soman, a highly toxic anticholinesterase agent, was examined in mice and guinea pigs. The maximal protection produced by the oximes PAM and HI-6 varied as much as 6-fold between these species. Since endogenous carboxylesterase (CaE) is known to be an important determinant of species variation in soman toxicity, the protection of PAM and HI-6 against soman was also measured in animals whose endogenous CaE was inhibited with cresylbenzodioxaphosphorin oxide. In CaE-inhibited animals the soman LD50 values were similar in unprotected mice and guinea pigs (10.2 vs. 12.2-mu-g/kg) and oxime-protected mice and guinea pigs (38.1 vs. 40.3-mu-g/kg for PAM; 159 vs. 151-mu-g/kg for HI-6). The levels of oxime protection observed in CaE-inhibited animals agreed with previous experiments in other species that have no endogenous plasma CaE. The 4-5 times greater in vivo protection against soman of HI-6 vs. PAM in CaE-inhibited animals correlated with in vitro experiments in which HI-6 produced 3-5 times more oxime reactivation of soman-inhibited AChE than PAM. RP MAXWELL, DM (reprint author), USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010, USA. NR 32 TC 37 Z9 37 U1 0 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0149-7634 J9 NEUROSCI BIOBEHAV R JI Neurosci. Biobehav. Rev. PD SPR PY 1991 VL 15 IS 1 BP 135 EP 139 DI 10.1016/S0149-7634(05)80105-8 PG 5 WC Behavioral Sciences; Neurosciences SC Behavioral Sciences; Neurosciences & Neurology GA FC484 UT WOS:A1991FC48400023 PM 2052186 ER PT J AU MATTHEW, CB AF MATTHEW, CB TI ANTICHOLINERGICS - EFFECTS ON THERMOREGULATION AND PERFORMANCE IN RATS SO NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS LA English DT Article; Proceedings Paper CT SYMP ON ANIMAL-TO-HUMAN EXTRAPOLATION : ISSUES AND OPPORTUNITIES CY MAR 13-15, 1990 CL SAN ANTONIO, TX SP UNIV TEXAS SAN ANTONIO, COLL SCI & ENGN, DIV LIFE SCI, USAF, DIV HUMAN SYST, MED READINESS ADV DEV OFF, USAF, SCH AEROSP MED, DIV RADIAT SCI, SYST RES LAB, USN, MED RES & DEV COMMAND DE ANTICHOLINERGIC; ANTICHOLINESTERASE; RAT; MODEL; NICOTINIC; MUSCARINIC; EXERCISE; TEMPERATURE REGULATION; HYPERTHERMIA ID HEAT-STRESSED RAT; PRETREATMENT DRUG; ATROPINE; PHYSOSTIGMINE; TRIHEXYPHENIDYL; APROPHEN; DIAZEPAM; COMBINATION; ANTAGONISTS; SCOPOLAMINE AB Atropine (AT) induces a dose-dependent increase in rate of rise of core temperature (heating rate) in sedentary heat-stressed rats, a muscarinic anticholinergic (MA) effect which is quantitatively similar to the increase in heating rate seen in heat-exposed men after equivalent atropine dose. In the heat-stressed rat, scopolamine (S) was found to have 16 x the MA effect of AT and, in the present study, aprophen (AP) and trihexyphenidyl (THP) manifested 0.067 x and 0.061 x the MA effect of AT. In rats exercising on a treadmill (11 m/min, 6-degrees incline, 26-degrees-C), physostigmine (PH) administration resulted in reduced endurance and increased heating rate, both of which were attenuated following AT administration-hypothesized to be a nicotinic anticholinergic (NA) effect. Optimum doses of anticholinergics to reverse the PH-induced decrements were: AT-200-mu-g/kg, S-8-16-mu-g/kg, AP-3000-mu-g/kg, and THP-800-mu-g/kg. These optimum NA doses for AT, S, and AP were the same as those predicted from their MA potency relative to AT in heat-stressed rats. However, it should be noted that 800-mu-g/kg of THP is only 1/4 of the expected 3200-mu-g/kg dose of THP based on MA equivalence to AT. Relative MA activities and optimum doses in PH-treated exercising rats appear to be due to differential MA and NA activities. Thus, a combination of both sedentary heat-stressed and exercising rat models may be useful in predicting relative cholinergic effects of new drugs with both MA and NA effects in man. RP MATTHEW, CB (reprint author), USA,ENVIRONM MED RES INST,KANSAS ST,NATICK,MA 01760, USA. NR 33 TC 10 Z9 11 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0149-7634 J9 NEUROSCI BIOBEHAV R JI Neurosci. Biobehav. Rev. PD SPR PY 1991 VL 15 IS 1 BP 141 EP 146 DI 10.1016/S0149-7634(05)80106-X PG 6 WC Behavioral Sciences; Neurosciences SC Behavioral Sciences; Neurosciences & Neurology GA FC484 UT WOS:A1991FC48400024 PM 2052187 ER PT J AU DMELLO, GD SIDELL, FR AF DMELLO, GD SIDELL, FR TI A MODEL FOR CARBAMATE AND ORGANOPHOSPHATE-INDUCED EMESIS IN HUMANS SO NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS LA English DT Article; Proceedings Paper CT SYMP ON ANIMAL-TO-HUMAN EXTRAPOLATION : ISSUES AND OPPORTUNITIES CY MAR 13-15, 1990 CL SAN ANTONIO, TX SP UNIV TEXAS SAN ANTONIO, COLL SCI & ENGN, DIV LIFE SCI, USAF, DIV HUMAN SYST, MED READINESS ADV DEV OFF, USAF, SCH AEROSP MED, DIV RADIAT SCI, SYST RES LAB, USN, MED RES & DEV COMMAND DE PHYSOSTIGMINE; SARIN; EMESIS; HUMANS; MARMOSETS ID PHYSOSTIGMINE; MONKEYS; SOMAN; TOXICITY; DRUG AB In human volunteers, studies to assess the adverse effects of the carbamate anticholinesterase physostigmine showed that the intramuscular dose observed to induce emesis in 50% of subjects tested (ED50) was 28.1 (23.5-120.7)-mu-g/kg. This dose reduced whole blood cholinesterase (ChE) activity to 60% of control values. Studies in marmosets to assess the behavioural toxicology of physostigmine showed that the corresponding ED50 and ChE activity values were 34.3 (21.5-55.8)-mu-g/kg and 66% respectively. Sarin was also shown to induce emesis in marmosets, but only at doses that reduced erythrocyte ChE activity to 12% of control values. These data seem also to correspond with reports of organophosphate poisoning in humans. It is concluded that the marmoset may be a very good model of both carbamate and organophosphate-induced emesis in humans. C1 USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010. RP DMELLO, GD (reprint author), CHEM DEF ESTAB,DIV BIOL,SALISBURY SP4 0JQ,WILTS,ENGLAND. NR 26 TC 5 Z9 5 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0149-7634 J9 NEUROSCI BIOBEHAV R JI Neurosci. Biobehav. Rev. PD SPR PY 1991 VL 15 IS 1 BP 179 EP 184 DI 10.1016/S0149-7634(05)80112-5 PG 6 WC Behavioral Sciences; Neurosciences SC Behavioral Sciences; Neurosciences & Neurology GA FC484 UT WOS:A1991FC48400030 PM 1904998 ER PT J AU KANT, GJ SHIH, TM BERNTON, EW FEIN, HG SMALLRIDGE, RC MOUGEY, EH AF KANT, GJ SHIH, TM BERNTON, EW FEIN, HG SMALLRIDGE, RC MOUGEY, EH TI EFFECTS OF SOMAN ON NEUROENDOCRINE AND IMMUNE FUNCTION SO NEUROTOXICOLOGY AND TERATOLOGY LA English DT Article DE SOMAN; NEUROENDOCRINE; IMMUNE; RAT; PROLACTIN; GROWTH HORMONE; ACTH; CORTICOSTERONE; METOCLOPRAMIDE; CLONIDINE ID PITUITARY CYCLIC-AMP; CHOLINERGIC DRUGS; GROWTH-HORMONE; RAT-BRAIN; CORTICOSTERONE; PROLACTIN; INTOXICATION; STIMULATION; INHIBITION; SECRETION AB We have previously reported that plasma growth hormone (GH) and prolactin levels were markedly decreased in rats two weeks following a single dose (100-mu-g/kg, SC) of soman. We have now conducted additional experiments to attempt to determine whether neuroendocrine responses to physiological or pharmacological challenge are altered in rat survivors of soman exposure, and whether immune function, which can be affected by circulating hormones, is altered in the soman-exposed rats. In the present study, basal prolactin levels were not significantly lower in the soman-treated rats although prolactin increases in response to physiological or pharmacological challenge were attenuated. Also, basal growth hormone levels in soman survivors were similar to control levels in 2 of 3 experiments in the present report. In the third experiment, growth hormone levels were lower in soman-treated animals. Endocrine abnormalities appeared to be related to the severity of soman insult as assessed by changes in body weight following exposure. Both ACTH and prolactin responses to stress were impaired in a severely affected subpopulation of soman survivors. The thymus, an important immune organ, was decreased in weight in severely affected soman survivors, but other tests of immune function did not show differences between control and soman-exposed rats. C1 WALTER REED ARMY MED CTR,DEPT CLIN PHYSIOL,WASHINGTON,DC 20307. USA,MED RES INST CHEM DEF,BIOCHEM PHARMACOL BRANCH,ABERDEEN PROVING GROUND,MD 21010. RP KANT, GJ (reprint author), WALTER REED ARMY MED CTR,DEPT MED NEUROSCI,WASHINGTON,DC 20307, USA. NR 30 TC 10 Z9 10 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0892-0362 J9 NEUROTOXICOL TERATOL JI Neurotoxicol. Teratol. PD MAR-APR PY 1991 VL 13 IS 2 BP 223 EP 228 DI 10.1016/0892-0362(91)90014-N PG 6 WC Neurosciences; Toxicology SC Neurosciences & Neurology; Toxicology GA FD442 UT WOS:A1991FD44200014 PM 1646383 ER PT J AU WHITE, WL GLOVER, AT BUCKNER, AB AF WHITE, WL GLOVER, AT BUCKNER, AB TI EFFECT OF BLINKING ON TEAR ELIMINATION AS EVALUATED BY DACRYOSCINTIGRAPHY SO OPHTHALMOLOGY LA English DT Article ID FLOW AB To document the change in drainage of tears that occurs with blinking, the authors evaluated 17 lacrimal systems of 12 individuals with dacryoscintigraphy. A significant difference in tear drainage was found by keeping the eyelids closed during the first 2 minutes after drop placement (P < 0.03), but not from 2 to 5 minutes (P > 0.4). Retardation of tear drainage after droplet placement can be achieved by simple eyelid closure for 2 minutes. C1 BROOKE ARMY MED CTR,OPHTHALMOL SERV,FT SAM HOUSTON,TX 78234. TRIPLER ARMY MED CTR,DEPT NUCL SCI,HONOLULU,HI 96859. NR 13 TC 14 Z9 14 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0161-6420 J9 OPHTHALMOLOGY JI Ophthalmology PD MAR PY 1991 VL 98 IS 3 BP 367 EP 369 PG 3 WC Ophthalmology SC Ophthalmology GA FA654 UT WOS:A1991FA65400022 PM 2023758 ER PT J AU WALTERS, CP AF WALTERS, CP TI REMOVING THE AUTOMATIC TARGET RECOGNITION PERFORMANCE EVALUATION BOTTLENECK - THE C2NVEO AUTOSPEC FACILITY SO OPTICAL ENGINEERING LA English DT Article DE SIGNAL AND IMAGE PROCESSING; AUTOMATIC TARGET RECOGNITION AB The near-real-time end-to-end evaluation of automatic target recognizers has been a reality in the laboratory environment for several years. Depending on the reliability of ground truth data, i.e., target location and sensor location in three dimensions and sensor pointing angle, field test evaluations could also be conducted at near real-time rates. End-to-end evaluations, however, are inadequate for producing the quantity and quality of data needed for understanding both successes and failures of automatic recognition. The C2NVEO has developed a facility, called AUTO-SPEC, for the expressed purpose of extracting intermediate data from processors. Once extracted, the data are stored in a relational database for subsequent analysis. The facility includes both the hardware and a number of software tools, developed at C2NVEO, designed to allow ready access to ground truth data, images, metrics, processor parameters, processor intermediate decisions, and processor final decisions. This paper presents the structure of the system and demonstrations of the tools developed. RP WALTERS, CP (reprint author), USA,CECOMS,CTR NIGHT VIS & ELECTROOPT,AMSEL RD NV V LET,FT BELVOIR,VA 22060, USA. NR 3 TC 4 Z9 4 U1 0 U2 0 PU SOC PHOTO-OPT INSTRUM ENG PI BELLINGHAM PA PO BOX 10, BELLINGHAM, WA 98227-0010 SN 0091-3286 J9 OPT ENG JI Opt. Eng. PD MAR PY 1991 VL 30 IS 3 BP 247 EP 253 DI 10.1117/12.55806 PG 7 WC Optics SC Optics GA FA811 UT WOS:A1991FA81100001 ER PT J AU NOAH, PV NOAH, MA SCHROEDER, J CHERNICK, J AF NOAH, PV NOAH, MA SCHROEDER, J CHERNICK, J TI BACKGROUND CHARACTERIZATION TECHNIQUES FOR TARGET DETECTION USING SCENE METRICS AND PATTERN-RECOGNITION SO OPTICAL ENGINEERING LA English DT Article DE IR IMAGE ANALYSIS; TARGET DETECTION; TARGET EVALUATION; AUTONOMOUS HOMING MUNITIONS; IMAGE METRICS; PERFORMANCE EVALUATION ID TEXTURE AB The U. S. Army has a requirement to develop systems for the detection and identification of ground targets in a clutter environment. Autonomous Homing Munitions (AHM) using infrared, visible, millimeter wave and other sensors are being investigated for this application. Advanced signal processing and computational approaches using pattern recognition and artificial intelligence techniques combined with multisensor data fusion have the potential to meet the Army's requirements for next generation AHM. In a complex background scene the "problem" is as much one of clutter rejection as it is target detection. This work applies statistical pattern recognition approaches to background clutter characterization for target detection and identification. These techniques are used to evaluate a set of image metrics applied to infrared terrain clutter scenes. C1 USA,MAT SYST ANAL ACT,ABERDEEN PROVING GROUND,MD 21005. RP NOAH, PV (reprint author), ONTAR CORP,129 UNIV RD,BROOKLINE,MA 02146, USA. NR 11 TC 3 Z9 3 U1 0 U2 1 PU SOC PHOTO-OPT INSTRUM ENG PI BELLINGHAM PA PO BOX 10, BELLINGHAM, WA 98227-0010 SN 0091-3286 J9 OPT ENG JI Opt. Eng. PD MAR PY 1991 VL 30 IS 3 BP 254 EP 258 DI 10.1117/12.55807 PG 5 WC Optics SC Optics GA FA811 UT WOS:A1991FA81100002 ER PT J AU BACH, DE NEWHOUSE, RF BOICE, GW AF BACH, DE NEWHOUSE, RF BOICE, GW TI SIMULTANEOUS ORTHOGNATHIC SURGERY AND CERVICOMENTAL LIPOSUCTION - CLINICAL AND SURVEY RESULTS SO ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS LA English DT Article ID SUCTION LIPECTOMY; AUGMENTATION; MUSCLE; NECK AB Adjunctive soft tissue surgical procedures to enhance facial esthetics can be performed simultaneously with orthognathic surgery. Submental-submandibular liposuction was performed with orthognathic surgical procedures in 22 patients from April 1989 to May 1990. Patients ranged in age from 18 to 48 years. Fourteen patients had submental and eight patients had both submental and infralobular incisions. The average estimated amount of fat removed was 40 to 50 cc. In this series of patients there was a marked improvement in facial esthetics. Liposuction created greater definition of the submandibular region and a more distinct jawline, with an improved cervicomental angle. Patients appeared younger. No significant complications occurred, and patient satisfaction was high. A survey of oral and maxillofacial surgery training programs in the United States was conducted to determine experiences with liposuction. Survey results are presented. Our survey results are consistent with our clinical experiences with this procedure. RP BACH, DE (reprint author), TRIPLER ARMY MED CTR,DENT ACT,ORAL & MAXILLOFACIAL SURG SERV,HONOLULU,HI 96859, USA. NR 13 TC 2 Z9 2 U1 1 U2 3 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 1079-2104 J9 ORAL SURG ORAL MED O JI Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. PD MAR PY 1991 VL 71 IS 3 BP 262 EP 266 DI 10.1016/0030-4220(91)90296-O PG 5 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA FB695 UT WOS:A1991FB69500002 PM 2011346 ER PT J AU BURKOT, TR DA, ZW GEYSEN, HM WIRTZ, RA SAUL, A AF BURKOT, TR DA, ZW GEYSEN, HM WIRTZ, RA SAUL, A TI FINE SPECIFICITIES OF MONOCLONAL-ANTIBODIES AGAINST THE PLASMODIUM-FALCIPARUM CIRCUMSPOROZOITE PROTEIN - RECOGNITION OF BOTH REPETITIVE AND NONREPETITIVE REGIONS SO PARASITE IMMUNOLOGY LA English DT Article DE CIRCUMSPOROZOITE PROTEIN; PLASMODIUM-FALCIPARUM; MONOCLONAL ANTIBODIES ID HUMAN MALARIA PARASITE; BLOOD STAGES; SHARES DETERMINANTS; CS PROTEIN; SPOROZOITES; ANTIGEN; TRANSMISSION; SEQUENCE; INVITRO; DOMAINS AB The fine specificities of 6 monoclonal antibodies (MoAbs) raised against the circumsporozoite (CS) protein of the human malaria parasite, Plasmodium falciparum, were defined by their binding to a series of overlapping octapeptides corresponding to the 7G8 variant of the CS protein. The precise specificities of the MoAbs to the immunodominant NANP repeat region were elucidated by their binding to all possible 4, 5, 6, 7 and 8 amino acid peptides in this region. All 6 MoAbs recognized the NANP repeats. In addition all MoAb bound to nonrepetitive sites with 4 of the 6 MoAbs recognizing known functional sites outside the repeat region including sites required for T cell recognition and hepatocyte invasion. Antibody pressure may therefore be responsible for generating the epitope variation observed at T cell sites. The multiple specificities for all the MoAbs suggests that the repeat region may act as an internal immunological 'smokescreen' by competing more effectively for antibody binding compared to single epitope copy functional sites located outside the repeat region. C1 COMMONWEALTH SERUM LABS,PARKVILLE,VIC 3052,AUSTRALIA. WALTER REED ARMY MED CTR,DEPT ENTOMOL,WASHINGTON,DC 20307. RP BURKOT, TR (reprint author), QUEENSLAND INST MED RES,TROP HLTH PROGRAM,HERSTON,QLD 4006,AUSTRALIA. RI Burkot, Thomas/C-6838-2013; Saul, Allan/I-6968-2013 OI Saul, Allan/0000-0003-0665-4091 NR 23 TC 29 Z9 29 U1 0 U2 2 PU BLACKWELL SCIENCE LTD PI OXFORD PA OSNEY MEAD, OXFORD, OXON, ENGLAND OX2 0EL SN 0141-9838 J9 PARASITE IMMUNOL JI Parasite Immunol. PD MAR PY 1991 VL 13 IS 2 BP 161 EP 170 DI 10.1111/j.1365-3024.1991.tb00272.x PG 10 WC Immunology; Parasitology SC Immunology; Parasitology GA FF102 UT WOS:A1991FF10200005 PM 2052404 ER PT J AU WEISSE, ME BASS, JW JARRETT, RV VINCENT, JM AF WEISSE, ME BASS, JW JARRETT, RV VINCENT, JM TI NONANTHRAX BACILLUS INFECTIONS OF THE CENTRAL-NERVOUS-SYSTEM SO PEDIATRIC INFECTIOUS DISEASE JOURNAL LA English DT Article DE BACILLUS-SPP; MENINGITIS; NEONATAL; MENINGOMYELOCELE ID CEREUS MENINGITIS; CEREBROSPINAL-FLUID; SERIOUS INFECTIONS; BACTEREMIA; PATIENT; SHUNTS; CANCER RP WEISSE, ME (reprint author), TRIPLER ARMY MED CTR,DEPT PEDIAT,HONOLULU,HI 96859, USA. NR 32 TC 16 Z9 16 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0891-3668 J9 PEDIATR INFECT DIS J JI Pediatr. Infect. Dis. J. PD MAR PY 1991 VL 10 IS 3 BP 243 EP 246 DI 10.1097/00006454-199103000-00014 PG 4 WC Immunology; Infectious Diseases; Pediatrics SC Immunology; Infectious Diseases; Pediatrics GA FC019 UT WOS:A1991FC01900014 PM 1904148 ER PT J AU KULLAMA, LK BALARAMAN, V CLAYBAUGH, JR ICHIMURA, WM PICHOFF, BE NAKAMURA, KT AF KULLAMA, LK BALARAMAN, V CLAYBAUGH, JR ICHIMURA, WM PICHOFF, BE NAKAMURA, KT TI DIFFERENTIAL ONTOGENY OF INVITRO VASCULAR-RESPONSES TO 3 CATEGORIES OF CALCIUM-CHANNEL ANTAGONISTS IN RATS SO PEDIATRIC RESEARCH LA English DT Article ID SMOOTH-MUSCLE; RECEPTOR-SITES; ENTRY BLOCKERS; BLOCKING-DRUGS; BINDING-SITES; AORTA; DIHYDROPYRIDINE; NITRENDIPINE; CONTRACTIONS; APPEARANCE AB We examined the ontogeny of relaxation responses to three categories of calcium channel antagonists, represented by verapamil, diltiazem, and nifedipine, for both potential-operated (KCl-mediated) and receptor-operated channels [norepinephrine (NE)-mediated] in rat thoracic aorta. Aortic rings from 2- to 3-d, 1-wk, and 12-wk-old Sprague Dawley rats were mounted in an organ bath, bathed in Krebs' solution, and connected to a force-displacement transducer to measure isometric tension. Endothelium intact vessels at optimal passive force were exposed to a single ED50 of isotonic KCl or NE, equilibrium contraction was measured, then vessels were washed and exposed for 30 min to 1-mu-M verapamil, 1-mu-M diltiazem, or 0.1-mu-M nifedipine, followed by another dose of KCl or NE. Verapamil and diltiazem demonstrated significant (p < 0.05) age-related increases in effectiveness for blocking KCl-mediated contraction [(% reduction of control contraction +/- SEM) (Verapamil: 2-3 d, 67.7 +/- 4.2; 1 wk, 72.5 +/- 1.8; 12 wk, 89.5 +/- 1.0. Diltiazem: 2-3 d, 64.6 +/- 2.9; 1 wk, 73.5 +/- 3.0; 12 wk, 83.1 +/- 1.8]. Nifedipine was equally effective at all ages: 2-3 d, 85.6 +/- 1.3; 1 wk, 90.0 +/- 1.6; and 12 wk, 91.3 +/- 1.4. Verapamil and diltiazem also showed significant age-related increases in effectiveness for blocking NE-mediated contraction (Verapamil: 2-3 d, 6.2 +/- 3.9; 1 wk, 28.0 +/- 4.8; 12 wk, 44.1 +/- 6.0. Diltiazem: 2-3 d, 8.0 +/- 3.1; 1 wk, 20.5 +/- 3.9; 12 wk, 46.5 +/- 4.8). Again, nifedipine was equally effective at all ages: 2-3 d, 42.0 +/- 6.8; 1 wk, 35.8 +/- 3.9; and 12 wk, 37.5 +/- 3.2. In summary, for the categories of calcium channel antagonists that interact at the phenylalkylamine (verapamil) and benzothiazepine (diltiazem) binding sites, there were age-related increases in effectiveness for blocking both potential-operated and receptor-operated channels. However, for nifedipine, which binds to the 1,4-dihydropyridine binding site, no maturational change was observed. These results suggest that the ontogeny of calcium channel antagonists' function may vary depending on the site of binding within the calcium channel. C1 KAPIOLANI MED CTR WOMEN & CHILDREN,DEPT PEDIAT,1319 PUNAHOU ST,RM 731,HONOLULU,HI 96826. TRIPLER ARMY MED CTR,DEPT CLIN INVEST,HONOLULU,HI 96859. TRIPLER ARMY MED CTR,DEPT PEDIAT,HONOLULU,HI 96859. NR 23 TC 4 Z9 4 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0031-3998 J9 PEDIATR RES JI Pediatr. Res. PD MAR PY 1991 VL 29 IS 3 BP 278 EP 281 DI 10.1203/00006450-199103000-00011 PG 4 WC Pediatrics SC Pediatrics GA EZ993 UT WOS:A1991EZ99300011 PM 1851981 ER PT J AU VEZZOLI, GC WALSH, PJ SHOGA, MA AF VEZZOLI, GC WALSH, PJ SHOGA, MA TI INTERPRETATION OF RECENT TRANSIENT ON-STATE DATA IN THIN CHALCOGENIDE GLASS AND NBO2 THRESHOLD SWITCHING MATERIAL SO PHILOSOPHICAL MAGAZINE B-PHYSICS OF CONDENSED MATTER STATISTICAL MECHANICS ELECTRONIC OPTICAL AND MAGNETIC PROPERTIES LA English DT Article ID POLYCRYSTALLINE NBO2; SEMICONDUCTOR; DECAY AB Recent measurements studying the on-regime of the transient on-state characteristics (TONC) of a thin amorphous semiconductor chalcogenide threshold switch, employing precisely balanced circuitry and isolated device voltage determination, have shown that the low-current subregime known as the blocked on-state develops when the decreasing ramp voltage rate dV/dt is equal to -7 x 10(-3) V ns-1. For a more rapid ramp rate of approximately -21 x 10(-3) V ns-1 the blocked on-state does not develop and the I-V curve will display metal-like behaviour. We have also observed TONCs for polycrystalline and single crystal NbO2. In this paper we present a band model based on amphoteric charged defects which gives a good description of these transient I-V characteristics and of the general switch-on and switch-off behaviour in thin films of these materials. The band model assumes equal densities of amphoteric charged defects in the off-state which allow localized conduction in the donor and acceptor bands of the defects simultaneous with extended-state band conduction. In the onstate, the charged trapping states are converted to their neutral counterparts. The defects may arise in a number of ways including Mott-Street dangling bonds, Kastner valence-alternation pairs, and Wauliewkicz intrinsic native vacancies. The switching to the on-state is essentially a Mott-Anderson transition. C1 FAIRLEIGH DICKINSON UNIV,DEPT ELECT ENGN,TEANECK,NJ 07666. HUGHES AIRCRAFT CO,LOS ANGELES,CA 90009. RUTGERS STATE UNIV,DEPT ELECT ENGN,SOLID STATE GRP,PISCATAWAY,NJ 08855. EXCITON SCIENCE INC,GARDEN GROVE,CA 92640. RP VEZZOLI, GC (reprint author), USA,MAT TECHNOL LAB,DIV EMERGING MAT,MAT RES BRANCH,WATERTOWN,MA 02172, USA. NR 31 TC 7 Z9 8 U1 0 U2 6 PU TAYLOR & FRANCIS LTD PI LONDON PA ONE GUNDPOWDER SQUARE, LONDON, ENGLAND EC4A 3DE SN 0141-8637 J9 PHILOS MAG B JI Philos. Mag. B-Phys. Condens. Matter Stat. Mech. Electron. Opt. Magn. Prop. PD MAR PY 1991 VL 63 IS 3 BP 739 EP 755 DI 10.1080/13642819108225983 PG 17 WC Materials Science, Multidisciplinary; Mechanics; Physics, Applied; Physics, Condensed Matter SC Materials Science; Mechanics; Physics GA FF207 UT WOS:A1991FF20700010 ER PT J AU ELSMORE, TF KANT, GJ BAUMAN, RA AF ELSMORE, TF KANT, GJ BAUMAN, RA TI EFFECTS OF SUSTAINED AVOIDANCE ESCAPE ON DEMAND FOR FOOD SO PHYSIOLOGY & BEHAVIOR LA English DT Article DE STRESS; CHRONIC STRESS; AVOIDANCE; ESCAPE; ECONOMICS; FEEDING; CIRCADIAN RHYTHMS; RATS ID CHRONIC STRESS; CORTICOSTERONE; PROLACTIN; BINDING AB Rats were concurrently exposed to a sustained avoidance/escape (SAE) procedure and a procedure for assessing demand for food. In the sustained SAE procedure, signalled shock avoidance/escape trials were presented at varying intervals averaging five minutes. The shock could be avoided by pulling on a ceiling chain early in the trial, or escaped by pulling on the chain later in the trial. Demand curves for food were generated by requiring 1, 5, 10, 20, 40, 80, 160, and 320 lever presses for each food pellet on successive days. The demand curve procedure was introduced after either brief (3 or 5 days) or extended (21 or 23 days) exposure to SAE. Following brief exposure to SAE, SAE animals showed decreased food intake and less elasticity of demand relative to non-SAE controls. Following extended exposure to SAE, these effects were diminished or absent. C1 WALTER REED ARMY MED CTR,DEPT MED NEUROSCI,WASHINGTON,DC 20307. NR 14 TC 6 Z9 6 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0031-9384 J9 PHYSIOL BEHAV JI Physiol. Behav. PD MAR PY 1991 VL 49 IS 3 BP 621 EP 624 DI 10.1016/0031-9384(91)90288-Y PG 4 WC Psychology, Biological; Behavioral Sciences SC Psychology; Behavioral Sciences GA FE047 UT WOS:A1991FE04700032 PM 2062940 ER PT J AU KANT, GJ BAUMAN, RA PASTEL, RH MYATT, CA CLOSSERGOMEZ, E DANGELO, CP AF KANT, GJ BAUMAN, RA PASTEL, RH MYATT, CA CLOSSERGOMEZ, E DANGELO, CP TI EFFECTS OF CONTROLLABLE VS UNCONTROLLABLE STRESS ON CIRCADIAN TEMPERATURE RHYTHMS SO PHYSIOLOGY & BEHAVIOR LA English DT Article DE CIRCADIAN RHYTHM; TEMPERATURE; STRESS; FEEDING ID LOCOMOTOR-ACTIVITY; BODY-TEMPERATURE; RAT; HYPERTHERMIA; DEPRESSION; BINDING AB The effects of sustained stress on body temperature were investigated in rats implanted with mini-transmitters that permitted remote measurement of body temperature. Temperature was first monitored during control conditions. Following the control period, rats were either shaped to avoid/escape signalled around-the-clock intermittent footshock (controllable stress) or yoked to the controlling rats such that the controlling rat and the yoked rat received shock of the same duration, but only the controlling rat could terminate shock by pulling a ceiling chain. Under control conditions, rats demonstrated regular rhythms in body temperature which averaged 1 degree higher during the 12-h dark cycle than the light cycle. Stress disrupted the rhythm and markedly decreased the night-day difference in temperature, especially in the yoked rats in which almost no difference between light and dark cycle temperature was seen. The disruption was most marked for the first days of stress. A regular temperature rhythm was reestablished following about 5 days of stress although the stress condition continued. Leverpressing for food was also affected by the stress conditions with both stress groups leverpressing less than controls and the uncontrollable stress group pressing less than the controllable stress group. These data offer additional evidence of the increased pathophysiological effects of uncontrollable as compared to controllable stress. RP KANT, GJ (reprint author), WALTER REED ARMY MED CTR,DEPT MED NEUROSCI,WASHINGTON,DC 20307, USA. NR 26 TC 47 Z9 47 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0031-9384 J9 PHYSIOL BEHAV JI Physiol. Behav. PD MAR PY 1991 VL 49 IS 3 BP 625 EP 630 DI 10.1016/0031-9384(91)90289-Z PG 6 WC Psychology, Biological; Behavioral Sciences SC Psychology; Behavioral Sciences GA FE047 UT WOS:A1991FE04700033 PM 2062941 ER PT J AU VINSON, RP COLLETTE, RP AF VINSON, RP COLLETTE, RP TI MAXILLARY SINUS HYPOPLASIA MASQUERADING AS CHRONIC SINUSITIS SO POSTGRADUATE MEDICINE LA English DT Article AB Maxillary sinus hypoplasia is a common condition that may be misdiagnosed as chronic sinusitis. Although hypoplasia can usually be seen on conventional sinus films, computed tomography may be necessary, as in the cases described by the authors in this article. C1 USA,MARTIN COMMUNITY HOSP,DEPT OTOLARYNOL HEAD & NECK SURG,OTOLARYNGOL SERV,FT BENNING,GA 31905. GEN DISPENSARY 543,TAEGU,SOUTH KOREA. NR 6 TC 4 Z9 4 U1 0 U2 0 PU MCGRAW HILL HEALTHCARE PUBLICATIONS PI MINNEAPOLIS PA 4530 WEST 77TH ST, MINNEAPOLIS, MN 55435-5000 SN 0032-5481 J9 POSTGRAD MED JI Postgrad. Med. PD MAR PY 1991 VL 89 IS 4 BP 189 EP 190 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA FB285 UT WOS:A1991FB28500022 PM 2000352 ER PT J AU SMYTHE, JA COPPEL, RL DAY, KP MARTIN, RK ODUOLA, AMJ KEMP, DJ ANDERS, RF AF SMYTHE, JA COPPEL, RL DAY, KP MARTIN, RK ODUOLA, AMJ KEMP, DJ ANDERS, RF TI STRUCTURAL DIVERSITY IN THE PLASMODIUM-FALCIPARUM MEROZOITE SURFACE ANTIGEN-2 SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA LA English DT Article DE MALARIA; PROTEIN POLYMORPHISMS; REPEAT SEQUENCES ID GENE; PRECURSOR; SEQUENCE; MALARIA; IDENTIFICATION; GLYCOPROTEIN; POLYMORPHISM; PROTEINS; REPEATS AB Antigens associated with the surface of merozoites of the malaria parasite Plasmodium falciparum are directly accessible to immune attack and therefore are prime vaccine candidates. We have previously shown that one of the two known merozoite surface antigens (merozoite surface antigen 2; MSA-2) exhibits considerable sequence and antigenic diversity in different isolates. The sequences of MSA-2 from three isolates revealed a central domain composed of repeats that vary in number, length, and sequence, flanked in turn by nonrepetitive variable sequences and by conserved N-and C-terminal domains. We report here the sequences of a further four MSA-2 alleles, containing repetitive sequences that are related but not identical to each other. The seven alleles of MSA-2 can be divided into two distinct allele families on the basis of nonrepetitive sequences. Hybridization studies with repeat probes indicated that all of the 44 P. falciparum isolates examined contained repeat regions similar to those defined in known MSA-2 sequences. C1 ROYAL MELBOURNE HOSP,WALTER & ELIZA HALL INST MED RES,PARKVILLE,VIC 3050,AUSTRALIA. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. UNIV IBADAN,IBADAN,NIGERIA. RI Coppel, Ross/A-6626-2008; Day, Karen/F-3697-2015 OI Coppel, Ross/0000-0002-4476-9124; Day, Karen/0000-0002-6115-6135 NR 23 TC 145 Z9 151 U1 0 U2 0 PU NATL ACAD SCIENCES PI WASHINGTON PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 SN 0027-8424 J9 P NATL ACAD SCI USA JI Proc. Natl. Acad. Sci. U. S. A. PD MAR PY 1991 VL 88 IS 5 BP 1751 EP 1755 DI 10.1073/pnas.88.5.1751 PG 5 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA FA140 UT WOS:A1991FA14000033 PM 2000383 ER PT J AU ARTENSTEIN, AW HICKS, CB GOODWIN, BS HILLIARD, JK AF ARTENSTEIN, AW HICKS, CB GOODWIN, BS HILLIARD, JK TI HUMAN INFECTION WITH B-VIRUS FOLLOWING A NEEDLESTICK INJURY SO REVIEWS OF INFECTIOUS DISEASES LA English DT Review ID HERPESVIRUS-SIMIAE; IDENTIFICATION; COLONIES; MONKEYS; SIMPLEX; COMMON AB A 26-year-old veterinary technician who became infected with B virus at the site of a needle-stick injury is described. After the patient was treated with intravenous acyclovir, all cultures became negative for B virus and have remained so during treatment with oral acyclovir. The literature on infections due to B virus in humans is reviewed, and a detailed discussion of the various aspects of this simian herpesvirus is presented. C1 WALTER REED ARMY MED CTR,DIV VET MED,WASHINGTON,DC 20307. SW FDN BIOMED RES,SAN ANTONIO,TX 78284. RP ARTENSTEIN, AW (reprint author), WALTER REED ARMY MED CTR,DEPT MED,INFECT DIS SERV,WASHINGTON,DC 20307, USA. NR 41 TC 41 Z9 41 U1 0 U2 1 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0162-0886 J9 REV INFECT DIS PD MAR-APR PY 1991 VL 13 IS 2 BP 288 EP 291 PG 4 WC Immunology; Microbiology SC Immunology; Microbiology GA FD047 UT WOS:A1991FD04700017 PM 1645881 ER PT J AU BROWN, JE ECHEVERRIA, P LINDBERG, AA AF BROWN, JE ECHEVERRIA, P LINDBERG, AA TI DIGALACTOSYL-CONTAINING GLYCOLIPIDS AS CELL-SURFACE RECEPTORS FOR SHIGA TOXIN OF SHIGELLA-DYSENTERIAE-1 AND RELATED CYTOTOXINS OF ESCHERICHIA-COLI SO REVIEWS OF INFECTIOUS DISEASES LA English DT Article; Proceedings Paper CT WORKSHOP ON INVASIVE DIARRHEAS, SHIGELLOSIS, AND DYSENTERY CY DEC 07-09, 1988 CL MAHIDOL UNIV, SALAYA CAMPUS, BANGKOK, THAILAND SP HARVARD INST INT HLTH, JOHNS HOPKINS SCH HYGIENE & TROP MED, DEPT INT HLTH, NEW ENGLAND MED CTR, DIV GEOG MED & INFECTIOUS DIS HO MAHIDOL UNIV, SALAYA CAMPUS ID SHIGELLA-DYSENTERIAE 1; P-BLOOD-GROUP; HELA-CELLS; GLOBOTRIOSYL CERAMIDE; PATHOGENESIS; BINDING; DIARRHEA; GLOBOTRIAOSYLCERAMIDE; IDENTIFICATION; PROTEIN AB Purified glycolipids containing galactose-alpha(1-4)galactose bind with Shiga toxin of Shigella dysenteriae 1 and Shiga-like toxins of Escherichia coli with high specificity in both thin-layer chromatograms and glycolipid-coated microtiter plates. These glycolipids appear to be the natural cell surface receptors for this class of bacterial toxins since artificial glycoconjugates block cytotoxicity as well as binding of I-125-labeled toxin. Cell lines lacking these glycolipids are refractory to toxin action. Assays in which synthetic glycoconjugates and purified glycolipids are used as capture reagents have been developed for the detection of the toxins. C1 ARMED FORCES RES INST MED SCI,BANGKOK,THAILAND. KAROLINSKA INST,HUDDINGE UNIV HOSP,DEPT CLIN BACTERIOL,S-14186 HUDDINGE,SWEDEN. NR 36 TC 24 Z9 24 U1 0 U2 1 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0162-0886 J9 REV INFECT DIS PD MAR-APR PY 1991 VL 13 SU 4 BP S298 EP S303 PG 6 WC Immunology; Microbiology SC Immunology; Microbiology GA FD059 UT WOS:A1991FD05900015 PM 2047653 ER PT J AU ECHEVERRIA, P SETHABUTR, O PITARANGSI, C AF ECHEVERRIA, P SETHABUTR, O PITARANGSI, C TI MICROBIOLOGY AND DIAGNOSIS OF INFECTIONS WITH SHIGELLA AND ENTEROINVASIVE ESCHERICHIA-COLI SO REVIEWS OF INFECTIOUS DISEASES LA English DT Article; Proceedings Paper CT WORKSHOP ON INVASIVE DIARRHEAS, SHIGELLOSIS, AND DYSENTERY CY DEC 07-09, 1988 CL MAHIDOL UNIV, SALAYA CAMPUS, BANGKOK, THAILAND SP HARVARD INST INT HLTH, JOHNS HOPKINS SCH HYGIENE & TROP MED, DEPT INT HLTH, NEW ENGLAND MED CTR, DIV GEOG MED & INFECTIOUS DIS HO MAHIDOL UNIV, SALAYA CAMPUS ID ENDEMIC DIARRHEAL DISEASE; THAI CHILDREN; VIRULENCE; PLASMID; DYSENTERY; PATHOGENS; ENTEROPATHOGENS; AEROMONAS; FEATURES; FLEXNERI AB The etiology of dysentery in Thailand and the existing methods of diagnosing infections with Shigella and enteroinvasive Escherichia coli (EIEC) are reviewed. The four Shigella species (S. dysenteriae, S. flexneri, S. boydii, and S. sonnei) are classically identified by culture of fecal specimens on selective media and testing of isolates for agglutination in species-specific antisera. DNA probes have been used to identify both lactose-fermenting and non-lactose-fermenting EIEC as well as Shigella isolates that do not agglutinate in antisera. These DNA probes are not necessary for the identification of Shigella if a competent bacteriology laboratory with shigella antisera is available. In Thailand Shigella and EIEC are isolated more often from children > 2 years of age than from younger children. The clinical illness associated with EIEC infections is similar to shigellosis. Fewer children with EIEC infections than with shigellosis, however, have occult blood in stool (36% vs. 82%) and more than 10 fecal leukocytes per high-power field (36% vs. 67%). Standard bacteriologic methods and testing of E. coli isolates for hybridization with the shigella/EIEC probe are currently the most sensitive means of diagnosing infections caused by these enteric pathogens. A more rapid method of identifying Shigella and EIEC infections in a situation where a bacteriology laboratory is not available will probably involve immunologic assays. C1 ARMED FORCES RES INST MED SCI,DEPT BACTERIOL,BANGKOK,THAILAND. NR 43 TC 34 Z9 36 U1 0 U2 3 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0162-0886 J9 REV INFECT DIS PD MAR-APR PY 1991 VL 13 SU 4 BP S220 EP S225 PG 6 WC Immunology; Microbiology SC Immunology; Microbiology GA FD059 UT WOS:A1991FD05900002 PM 2047641 ER PT J AU TAYLOR, DN BODHIDATTA, L ECHEVERRIA, P AF TAYLOR, DN BODHIDATTA, L ECHEVERRIA, P TI EPIDEMIOLOGIC ASPECTS OF SHIGELLOSIS AND OTHER CAUSES OF DYSENTERY IN THAILAND SO REVIEWS OF INFECTIOUS DISEASES LA English DT Article; Proceedings Paper CT WORKSHOP ON INVASIVE DIARRHEAS, SHIGELLOSIS, AND DYSENTERY CY DEC 07-09, 1988 CL MAHIDOL UNIV, SALAYA CAMPUS, BANGKOK, THAILAND SP HARVARD INST INT HLTH, JOHNS HOPKINS SCH HYGIENE & TROP MED, DEPT INT HLTH, NEW ENGLAND MED CTR, DIV GEOG MED & INFECTIOUS DIS HO MAHIDOL UNIV, SALAYA CAMPUS ID ENTEROINVASIVE ESCHERICHIA-COLI; DIARRHEAL DISEASE; RISK-FACTORS; CHILDREN; ENTEROPATHOGENS; INFECTIONS; BANGLADESH; PATHOGENS AB Nearly 20% of children seen in the outpatient department of Children's Hospital in Bangkok, Thailand, for diarrheal disease had bloody diarrhea. Shigella species and enteroinvasive Escherichia coli-isolated from 13% and 2% of children with diarrhea, respectively-were the most frequent causes of bloody diarrhea. Campylobacter species and nontyphoidal Salmonella species were also isolated frequently but were much less often associated with bloody diarrhea. Shigella species were rarely isolated from patients who did not have diarrhea, while Campylobacter and Salmonella species were isolated frequently from well children. None of the species isolated always caused bloody diarrhea. Studies on infection with Campylobacter suggest that natural immunity may prevent bloody diarrhea and in fact may eventually prevent all disease due to this organism. Studies of endemic Shigella flexneri and epidemic Shigella dysenteriae 1 in Thailand have shown that immunity may also explain an age-related decrease in rates of S. flexneri infection but not in rates of S. dysenteriae 1 isolation. C1 ARMED FORCES RES INST MED SCI,DEPT BACTERIOL,BANGKOK,THAILAND. NR 28 TC 16 Z9 16 U1 2 U2 3 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0162-0886 J9 REV INFECT DIS PD MAR-APR PY 1991 VL 13 SU 4 BP S226 EP S230 PG 5 WC Immunology; Microbiology SC Immunology; Microbiology GA FD059 UT WOS:A1991FD05900003 PM 2047642 ER PT J AU ASCHER, DP BASH, MC ZBICK, C WHITE, C AF ASCHER, DP BASH, MC ZBICK, C WHITE, C TI STOMATOCOCCUS-MUCILAGINOSUS CATHETER-RELATED INFECTION IN AN ADOLESCENT WITH OSTEOSARCOMA SO SOUTHERN MEDICAL JOURNAL LA English DT Article ID ENDOCARDITIS C1 WALTER REED ARMY MED CTR,DEPT CLIN MICROBIOL,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,DEPT PEDIAT INFECT DIS,BETHESDA,MD 20814. NR 12 TC 10 Z9 10 U1 0 U2 0 PU SOUTHERN MEDICAL ASSN PI BIRMINGHAM PA 35 LAKESHORE DR PO BOX 190088, BIRMINGHAM, AL 35219 SN 0038-4348 J9 SOUTHERN MED J JI South.Med.J. PD MAR PY 1991 VL 84 IS 3 BP 409 EP 410 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA FC892 UT WOS:A1991FC89200031 PM 2000540 ER PT J AU PACE, JG ROBINSON, NA MIURA, GA MATSON, CF GEISBERT, TW WHITE, JD AF PACE, JG ROBINSON, NA MIURA, GA MATSON, CF GEISBERT, TW WHITE, JD TI TOXICITY AND KINETICS OF [H-3] MICROCYSTIN-LR IN ISOLATED PERFUSED RAT LIVERS SO TOXICOLOGY AND APPLIED PHARMACOLOGY LA English DT Article ID ALGA MICROCYSTIS-AERUGINOSA; CYCLIC HEPTAPEPTIDE TOXINS; INVITRO; LR; CYANOBACTERIA; MICROSOMES; METABOLISM; CLEARANCE; PEPTIDE; INVIVO RP PACE, JG (reprint author), USA,MED RES INST INFECT DIS,DIV PATHOPHYSIOL,FT DETRICK,FREDERICK,MD 21702, USA. NR 24 TC 26 Z9 27 U1 0 U2 0 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0041-008X J9 TOXICOL APPL PHARM JI Toxicol. Appl. Pharmacol. PD MAR 1 PY 1991 VL 107 IS 3 BP 391 EP 401 DI 10.1016/0041-008X(91)90303-V PG 11 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA EZ947 UT WOS:A1991EZ94700001 PM 2000630 ER PT J AU MARSDEN, PD BADARO, R NETTO, EM CASLER, JD AF MARSDEN, PD BADARO, R NETTO, EM CASLER, JD TI SPONTANEOUS CLINICAL RESOLUTION WITHOUT SPECIFIC TREATMENT IN MUCOSAL LEISHMANIASIS SO TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE LA English DT Note C1 WALTER REED ARMY MED CTR,DEPT OTOLARYNGEAL,WASHINGTON,DC. UNIV BAHIA,IMMUNOL LAB,SALVADOR,BRAZIL. RP MARSDEN, PD (reprint author), UNIV BRASILIA,BR-70910 BRASILIA,DF,BRAZIL. RI Netto, Eduardo/D-1432-2013 OI Netto, Eduardo/0000-0003-1691-6761 NR 3 TC 5 Z9 5 U1 0 U2 0 PU ROYAL SOC TROPICAL MEDICINE PI LONDON PA MANSON HOUSE 26 PORTLAND PLACE, LONDON, ENGLAND W1N 4EY SN 0035-9203 J9 T ROY SOC TROP MED H JI Trans. Roy. Soc. Trop. Med. Hyg. PD MAR-APR PY 1991 VL 85 IS 2 BP 221 EP 221 DI 10.1016/0035-9203(91)90030-3 PG 1 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA FN691 UT WOS:A1991FN69100022 PM 1887476 ER PT J AU LEWIS, RM LEE, HW SEE, AF PARRISH, DB MOON, JS KIM, DJ COSGRIFF, TM AF LEWIS, RM LEE, HW SEE, AF PARRISH, DB MOON, JS KIM, DJ COSGRIFF, TM TI CHANGES IN POPULATIONS OF IMMUNE EFFECTOR-CELLS DURING THE COURSE OF HEMORRHAGIC-FEVER WITH RENAL SYNDROME SO TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID LYMPHOCYTE-T SUBSETS; HEMORRHAGIC-FEVER; MEDIATED-IMMUNITY; VIRUS; INFECTION; HANTAAN AB To characterize the immune response in haemorrhagic fever with renal syndrome, serial changes in immune effector cells were measured in 14 patients. Significant findings included initial elevations of all major leucocyte populations, increases in suppressor T cells and B cells, decreases in helper/suppressor cell ratios, and a dramatic increase in activated T cells. These changes were most marked in severely ill patients. Changes reverted to normal over approximately one week. C1 CAPITAL ARMY HOSP, SEOUL, SOUTH KOREA. USA, MED RES INST INFECT DIS, DIV MED, FREDERICK, MD 21701 USA. UNIV KOREA, INST VIRAL DIS, SEOUL, SOUTH KOREA. NR 20 TC 16 Z9 18 U1 1 U2 1 PU ROYAL SOC TROPICAL MEDICINE PI LONDON PA MANSON HOUSE 26 PORTLAND PLACE, LONDON, ENGLAND W1N 4EY SN 0035-9203 J9 T ROY SOC TROP MED H JI Trans. Roy. Soc. Trop. Med. Hyg. PD MAR-APR PY 1991 VL 85 IS 2 BP 282 EP 286 DI 10.1016/0035-9203(91)90058-7 PG 5 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA FN691 UT WOS:A1991FN69100044 PM 1679572 ER PT J AU BOSLEGO, JW TRAMONT, EC CHUNG, RC MCCHESNEY, DG CIAK, J SADOFF, JC PIZIAK, MV BROWN, JD BRINTON, CC WOOD, SW BRYAN, JR AF BOSLEGO, JW TRAMONT, EC CHUNG, RC MCCHESNEY, DG CIAK, J SADOFF, JC PIZIAK, MV BROWN, JD BRINTON, CC WOOD, SW BRYAN, JR TI EFFICACY TRIAL OF A PARENTERAL GONOCOCCAL PILUS VACCINE IN MEN SO VACCINE LA English DT Article DE NEISSERIA-GONORRHOEAE; NEISSERIA-GONORRHOEAE PILI; INHIBITION OF ATTACHMENT; LOCAL ANTIBODIES ID NEISSERIA-GONORRHOEAE; ESCHERICHIA-COLI; MONOCLONAL-ANTIBODIES; IMMUNOLOGIC CONTROL; OUTER-MEMBRANE; SUCKLING PIGS; TYPHOID FEVER; IMMUNIZATION; PROTECTION; VARIANTS AB A randomized, placebo-controlled, double-blind efficacy trial of a purified gonococcal pilus vaccine composed of a single pilus type was tested in 3123 men and 127 women volunteers. Either 100-mu-g of vaccine or a placebo was given intradermally on day 1 and day 14. Each group was evenly matched with respect to age, sex, prior history of a sexually transmitted disease, sexual exposure during the study and attrition from the study. None of the women volunteers acquired gonorrhoea during the trial. In the male volunteers, 108 vaccine and 102 placebo recipients acquired gonorrhoea 15 days or later after the initial immunization. Vaccines developed a sustained ELISA antibody response to homologous and heterologous pili, but the latter titres were approximately 40% as high as the homologous pilus antibody rises. There were, however, no increases in inhibition of attachment antibody (IEA) titres. Local antibodies (semen) against homologous and heterologous strains were also elicited (ELISA). The vaccine was safe and did not alter the clinical expression of disease. This gonococcal pilus vaccine composed of a single pilus type failed to protect men against gonococcal urethritis. C1 WALTER REED ARMY MED CTR,DEPT BACTERIAL DIS,DIV COMMUNICABLE DIS & IMMUNOL,WASHINGTON,DC 20307. UNIV PITTSBURGH,PITTSBURGH,PA 15260. NR 47 TC 83 Z9 85 U1 0 U2 1 PU BUTTERWORTH-HEINEMANN LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB SN 0264-410X J9 VACCINE JI Vaccine PD MAR PY 1991 VL 9 IS 3 BP 154 EP 162 DI 10.1016/0264-410X(91)90147-X PG 9 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA EZ099 UT WOS:A1991EZ09900002 PM 1675029 ER PT J AU VEENSTRA, JN NOLEN, SL AF VEENSTRA, JN NOLEN, SL TI INSITU SEDIMENT OXYGEN-DEMAND IN 5 SOUTHWESTERN UNITED-STATES LAKES SO WATER RESEARCH LA English DT Note DE SEDIMENT OXYGEN DEMAND; LAKES; DISSOLVED OXYGEN; SEDIMENTS; BENTHIC RESPIROMETER; INSITU SOD AB In situ sediment oxygen demand (SOD) was measured for five southwestern lakes from 1985 to 1988. Age, morphometry and trophic states varied among the lakes but all were thermally stratified and had anoxic hypolimnia during summer months. SOD measurements were obtained with a hemispherical, sealed chamber-type benthic respirometer fitted with a submersible recirculation pump and a sensor package for recording dissolved oxygen, temperature, conductivity and pH. SOD measurements were obtained at between two and four sites on most lakes. Temperature corrected values ranged from 0.34 to 9.02 g O2/m2.day. These data significantly expand the currently limited accessible SOD data base for Southwestern lakes. C1 USA CORPS ENGINEERS,TULSA,OK 74121. RP VEENSTRA, JN (reprint author), OKLAHOMA STATE UNIV,SCH CIVIL ENGN,STILLWATER,OK 74078, USA. NR 20 TC 22 Z9 24 U1 0 U2 4 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0043-1354 J9 WATER RES JI Water Res. PD MAR PY 1991 VL 25 IS 3 BP 351 EP 354 DI 10.1016/0043-1354(91)90016-J PG 4 WC Engineering, Environmental; Environmental Sciences; Water Resources SC Engineering; Environmental Sciences & Ecology; Water Resources GA FD213 UT WOS:A1991FD21300015 ER PT J AU MARSHALL, WJ AF MARSHALL, WJ TI DETERMINING HAZARD DISTANCES FROM NON-GAUSSIAN LASERS SO APPLIED OPTICS LA English DT Article ID BEAMS; DIVERGENCE; ORDER AB A simple method is presented for determining the nominal ocular hazard distance from non-Gaussian laser beams. The simplified method currently used for laser safety calculations when determining the laser beam diameter as a function of distance produces errors in the near field. The irradiance or radiant exposure of multimode and non-Gaussian laser beams in the near field may be calculated more precisely by the use of a simple proposed relationship with easily determined parameters. RP MARSHALL, WJ (reprint author), USA,ENVIRONM HYG AGCY,DIV LASER MICROWAVE,ABERDEEN PROVING GROUND,MD 21010, USA. NR 13 TC 5 Z9 5 U1 0 U2 0 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0003-6935 J9 APPL OPTICS JI Appl. Optics PD FEB 20 PY 1991 VL 30 IS 6 BP 696 EP 698 PG 3 WC Optics SC Optics GA EX560 UT WOS:A1991EX56000013 PM 20582045 ER PT J AU MIRANDA, MEG WHITE, ME DAYRIT, MM HAYES, CG KSIAZEK, TG BURANS, JP AF MIRANDA, MEG WHITE, ME DAYRIT, MM HAYES, CG KSIAZEK, TG BURANS, JP TI SEROEPIDEMIOLOGICAL STUDY OF FILOVIRUS RELATED TO EBOLA IN THE PHILIPPINES SO LANCET LA English DT Letter C1 USN,MED RES UNIT 2,SANTA CRUZ,PHILIPPINES. USA,INST INFECT DIS,FREDERICK,MD 21701. DEPT HLTH,TROP MED RES INST,MANILA,PHILIPPINES. RP MIRANDA, MEG (reprint author), DEPT HLTH,FIELD EPIDEMIOL TRAINING PROGRAM,MANILA,PHILIPPINES. NR 8 TC 40 Z9 43 U1 1 U2 10 PU LANCET LTD PI LONDON PA 42 BEDFORD SQUARE, LONDON, ENGLAND WC1B 3SL SN 0140-6736 J9 LANCET JI Lancet PD FEB 16 PY 1991 VL 337 IS 8738 BP 425 EP 426 DI 10.1016/0140-6736(91)91199-5 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA EX605 UT WOS:A1991EX60500028 PM 1671441 ER PT J AU SCHWARTZ, BL DEUTSCH, LH COHEN, C WARDEN, D DEUTSCH, SI AF SCHWARTZ, BL DEUTSCH, LH COHEN, C WARDEN, D DEUTSCH, SI TI MEMORY FOR TEMPORAL-ORDER IN SCHIZOPHRENIA SO BIOLOGICAL PSYCHIATRY LA English DT Article ID DORSOLATERAL PREFRONTAL CORTEX; CARD SORTING TEST; PHYSIOLOGIC DYSFUNCTION; AFFECTIVE-DISORDERS; INFORMATION; ATTENTION; RECALL; IMPAIRMENTS AB Memory for temporal order information was examined in patients with chronic schizophrenia using the recency discrimination task. In this task, subject were shown a pair of previously studied words and were asked to choose which one of the two words they had seen more recently. In addition, subjects performed the Wisconsin Card Sorting Test (WCST). The results showed that schizophrenic patients differed from normal control subjects in their performance on the recency discrimination task. In addition, for schizophrenic patients, performance on the recency discrimination task was inversely related to the number of perseverative errors on the WCST. These results provide further evidence of prefrontal-type cognitive deficits in schizophrenia. C1 GEORGETOWN UNIV,SCH MED,WASHINGTON,DC. JOHNS HOPKINS UNIV,SCH MED,DEPT PSYCHIAT,BALTIMORE,MD 21205. WALTER REED ARMY MED CTR,DEPT PSYCHIAT,WASHINGTON,DC 20307. NR 43 TC 65 Z9 65 U1 0 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0006-3223 J9 BIOL PSYCHIAT JI Biol. Psychiatry PD FEB 15 PY 1991 VL 29 IS 4 BP 329 EP 339 DI 10.1016/0006-3223(91)90218-B PG 11 WC Neurosciences; Psychiatry SC Neurosciences & Neurology; Psychiatry GA EZ690 UT WOS:A1991EZ69000003 PM 1674663 ER PT J AU TROMBETTA, LP FEIGL, FJ ZETO, RJ AF TROMBETTA, LP FEIGL, FJ ZETO, RJ TI POSITIVE CHARGE GENERATION IN METAL-OXIDE-SEMICONDUCTOR CAPACITORS SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID INDUCED PARAMAGNETIC DEFECTS; ELECTRON-SPIN RESONANCE; SILICON DIOXIDE; MOS STRUCTURES; HOLE TRAPS; INTERFACE; SIO2; RADIATION; SIO2-FILMS; CENTERS AB This work examines the electrical behavior of metal-oxide-semiconductor capacitors in which positive charge has been generated in the silicon dioxide layer using either avalanche hole injection, avalanche electron injection, or Fowler-Nordheim Tunneling injection. It is concluded on the basis of flatband voltage measurements made as a function of time following charge injection that two distinct species of positive charge are generated in the oxide layer, depending on the nature of charge generation. In particular, avalanche hole injection results in the generation of trapped holes, while avalanche electron injection and Fowler-Nordheim Tunneling result in so-called "slow-states" or anomalous positive charge centers. The electrical behavior of these two species is discussed. In addition, interface trap density measurements following avalanche hole injection show that both a background level of interface traps and a peak at approximately 0.8 eV above the valence band edge build with time following injection. Further, the dependence of the interface trap density on injection fluence and time supports a model in which a neutral species is released from the bulk of the oxide during hole injection and subsequently generates an interface defect. C1 LEHIGH UNIV,SHERMAN FAIRCHILD LAB SOLID STATE PHYS,BETHLEHEM,PA 18015. USA,LABCOM,FT MONMOUTH,NJ 07703. RP TROMBETTA, LP (reprint author), UNIV HOUSTON,DEPT ELECT ENGN,HOUSTON,TX 77004, USA. NR 33 TC 100 Z9 100 U1 1 U2 6 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD FEB 15 PY 1991 VL 69 IS 4 BP 2512 EP 2521 DI 10.1063/1.348689 PG 10 WC Physics, Applied SC Physics GA EZ664 UT WOS:A1991EZ66400105 ER PT J AU EDWARDS, AH JONES, KA AF EDWARDS, AH JONES, KA TI MOLECULAR-ORBITAL CALCULATIONS ON METHYL ALKYLS AND HYDRIDES USED IN THE ORGANOMETALLIC VAPOR-PHASE EPITAXY OF SOME III-V-SEMICONDUCTOR FILMS .1. SO JOURNAL OF CHEMICAL PHYSICS LA English DT Article ID MAIN-GROUP ELEMENTS; GALLIUM COMPOUNDS; RAMAN-SPECTRA; BASIS-SETS; GAAS; GROWTH; SPECTROSCOPY; INSITU; TRIMETHYLGALLIUM; AMMONIA AB We report ab initio and semiempirical calculations of the equilibrium geometries, bond strengths, and vibrational spectra of NH3, PH3, AsH3, (CH3)3Al, (CH3)3Ga, (CH3)3In, N(CH3)3, P(CH3)3, As(CH3)3, and some of their derived adducts as a function of basis set and of self-consistent field approximation. We compare our results to recent IR and Raman data, and to standard thermochemical data. We obtain very good agreement with experimental geometries, good agreement with experimental bond strengths, and only fair agreement (10%-20%) with experimental vibrational spectra. We argue that this purely theoretical approach is, with qualification, appropriate for predicting thermochemical parameters for gas-phase reactions that occur in organometallic vapor phase epitaxy of III-V semiconductor thin films. We expect to make reasonable predictions for barriers to chemical reactions, while use of our predictions of free energies will probably require care. C1 USA,ELECTR TECHNOL & DEVICES LAB,FT MONMOUTH,NJ 07703. RP EDWARDS, AH (reprint author), UNIV N CAROLINA,DEPT ELECT ENGN,CHARLOTTE,NC 28223, USA. NR 50 TC 29 Z9 29 U1 0 U2 3 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-9606 J9 J CHEM PHYS JI J. Chem. Phys. PD FEB 15 PY 1991 VL 94 IS 4 BP 2894 EP 2905 DI 10.1063/1.459811 PG 12 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA EY070 UT WOS:A1991EY07000058 ER PT J AU BROWN, ND PHILLIPS, LR LEADER, H CHIANG, PK AF BROWN, ND PHILLIPS, LR LEADER, H CHIANG, PK TI ISOLATION AND IDENTIFICATION OF BETA-HYDROXYETHYLAPROPHEN - A URINARY METABOLITE OF APROPHEN IN RATS SO JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS LA English DT Note AB The metabolism of the anticholinergic drug aprophen was studied in rats after oral administration via stomach intubation. Beta-Hydroxyethylaprophen, a major urinary metabolite of aprophen, was isolated and identified by normal-phase high-performance liquid chromatography and electron ionization mass spectrometry. More than 22% of the parent drug was recovered and quantified over a 72-h collection period. Results show that 2,2-diphenylpropionic acid, another major metabolite of aprophen which lacks anti-cholinergic properties, was also isolated and identified in this study. Experiments are currently underway to synthesize and test the anticholinergic properties of beta-hydroxyethylaprophen in mammals. C1 US FDA,DIV BIOCHEM & BIOPHYS,BETHESDA,MD 20892. RP BROWN, ND (reprint author), WALTER REED ARMY MED CTR,DIV BIOCHEM,WASHINGTON,DC 20307, USA. NR 6 TC 1 Z9 1 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-4347 J9 J CHROMATOGR-BIOMED JI J. Chromatogr.-Biomed. Appl. PD FEB 15 PY 1991 VL 563 IS 2 BP 466 EP 471 DI 10.1016/0378-4347(91)80057-J PG 6 WC Chemistry, Analytical SC Chemistry GA FB508 UT WOS:A1991FB50800027 PM 2056011 ER PT J AU COMISO, JC WADHAMS, P KRABILL, WB SWIFT, RN CRAWFORD, JP TUCKER, WB AF COMISO, JC WADHAMS, P KRABILL, WB SWIFT, RN CRAWFORD, JP TUCKER, WB TI TOP BOTTOM MULTISENSOR REMOTE-SENSING OF ARCTIC SEA ICE SO JOURNAL OF GEOPHYSICAL RESEARCH-OCEANS LA English DT Article ID THICKNESS DISTRIBUTION; FRAM STRAIT; MICROWAVE; SUMMER; ZONE AB The Arctic sea ice cover has been studied using near simultaneous observations by passive and active (synthetic aperture radar, SAR) microwave sensors, upward looking and sidescan sonars, a lidar profilometer, and an infrared sensor. Data from two aircraft and a submarine over an approximately 100 km track of central Arctic sea ice were registered and analyzed to evaluate the characteristics of the ice cover and the utility of each sensor in ice studies. The results of comparative and correlation analyses are as follows. The probability density functions of ice draft from sonar and elevation from lidar were found to be almost identical when isostasy is taken into account. This result suggests that the basic ice thickness distribution can be derived from the surface topography measurements alone. Reasonable correlation was found between SAR backscatter and ice draft (or elevation) especially when scales were adjusted such that 15-20 SAR pixels were averaged. However, surface roughness derived directly from standard deviations in the lidar elevation data was found to be poorly correlated to the SAR backscatter. These results indicate that the SAR values are affected more by scattering from the ice than from the snow-covered surface. The active and passive microwave sensors are shown to generally complement each other as the two sensors are especially sensitive to different physical properties of the sea ice. Undeformed first-year ice showed low backscatter values but high brightness temperatures while some multilayer ice showed high backscatter values and low brightness temperature. However, surfaces identified as multiyear ice by the passive system have a large spread in the unaveraged SAR backscatter, indicating limitations when using a one-channel SAR for ice type identification at the highest resolution. Also, ridged ice identified by sonar and SAR data covers a large range of passive microwave emissivity, suggesting considerable variability in the age and salinity of this type of ice. Significant variations (about 0.11) in the minimum emissivity of consolidated multilayer ice are observed in different regions of the Arctic using the high-resolution (30 m) passive microwave data. This suggests that regional variations in texture and scattering characteristics of multiyear ice in the Arctic are present, likely influenced by different histories of formation of the ice in different regions. C1 CALTECH,JET PROP LAB,PASADENA,CA 91109. NASA,GODDARD SPACE FLIGHT CTR,EG & G WASHINGTON ANALYT,GREENBELT,MD 20771. USA,CORPS ENGINEERS,COLD REG RES & ENGN LAB,HANOVER,NH 03755. UNIV CAMBRIDGE,SCOTT POLAR RES INST,CAMBRIDGE CB2 1ER,ENGLAND. RP COMISO, JC (reprint author), NASA,GODDARD SPACE FLIGHT CTR,HYDROSPHER PROC LAB,CODE 971,GREENBELT,MD 20771, USA. NR 27 TC 47 Z9 47 U1 0 U2 11 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 SN 0148-0227 J9 J GEOPHYS RES-OCEANS JI J. Geophys. Res.-Oceans PD FEB 15 PY 1991 VL 96 IS C2 BP 2693 EP 2709 DI 10.1029/90JC02466 PG 17 WC Oceanography SC Oceanography GA EY608 UT WOS:A1991EY60800014 ER PT J AU FINBLOOM, DS HOOVER, DL MELTZER, MS AF FINBLOOM, DS HOOVER, DL MELTZER, MS TI BINDING OF RECOMBINANT HIV COAT PROTEIN GP120 TO HUMAN MONOCYTES SO JOURNAL OF IMMUNOLOGY LA English DT Article ID HUMAN-IMMUNODEFICIENCY-VIRUS; MONONUCLEAR PHAGOCYTES; ENVELOPE GLYCOPROTEIN; AIDS RETROVIRUS; INFECTION; CD4; RECEPTOR; CELLS; MACROPHAGES AB Inasmuch as the exact level of CD4 Ag expression on macrophages is controversial and because HIV may interact with macrophages in a manner different from that on T cells, we analyzed the binding of gp120 to freshly isolated and cultured monocytes. rgp120 was iodinated using the lactoperoxidase method to a sp. act. of 600 Ci/mmol. Highly purified monocytes (> 90%) were isolated from the leukapheresed blood of normal volunteers by Ficoll-Hypaque sedimentation followed by countercurrent centrifugal elutriation and cultured 7 days in DMEM supplemented with 1000 U/ml macrophage CSF in 10% human serum. Whereas MOLT/4 cells consistently bound freshly prepared I-125-rgp120 at 80% specificity with 5100 +/- 700 mol/cell, MCSF cultured monocytes bound rgp120 at only 0 to 20% specificity and 420 +/- 200 mol/cell. Most of the radioactivity bound by these cells could not be blocked by the addition of unlabeled rgp120. In contrast, the U937 myeloid cell line bound rgp120 with 50% specificity and about 2500 mol/cell. Whereas the antibody OKT4a (anti-CD4) blocked 80% of the binding on MOLT/4 cells and 50% on U937 cells, binding was only inhibited on the average of 6% on cultured monocytes. When soluble rCD4 was used as an inhibitor, binding to MOLT/4 cells was blocked by 80%. In contrast, binding to cultured monocytes was inhibited by 28%. HIV infectivity was blocked by similar concentrations of OKT4a. These observations suggest that although most binding of gp120 to cultured monocytes is not to the CD4 determinant, several hundred molecules do bind to a CD4-like molecule which promotes virus entry and replication. C1 WALTER REED ARMY MED CTR,DEPT CELLULAR IMMUNOL,WASHINGTON,DC 20307. RP FINBLOOM, DS (reprint author), US FDA,CTR BIOL EVALUAT & RES,DIV CYTOKINE BIOL,8800 ROCKVILLE PIKE,BETHESDA,MD 20892, USA. NR 24 TC 38 Z9 38 U1 0 U2 0 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD FEB 15 PY 1991 VL 146 IS 4 BP 1316 EP 1321 PG 6 WC Immunology SC Immunology GA EW681 UT WOS:A1991EW68100036 PM 1991970 ER PT J AU CHOCK, SP RHEE, SG TANG, LC SCHMAUDERCHOCK, EA AF CHOCK, SP RHEE, SG TANG, LC SCHMAUDERCHOCK, EA TI LINKING PHOSPHOLIPASE-A2 TO PHOSPHOLIPID TURNOVER AND PROSTAGLANDIN SYNTHESIS IN MAST-CELL GRANULES SO EUROPEAN JOURNAL OF BIOCHEMISTRY LA English DT Article ID SECRETORY GRANULE; ARACHIDONIC-ACID; BOVINE BRAIN; FATTY-ACIDS; RAT-BRAIN; PHOSPHATIDYLINOSITOL; ACTIVATION; PURIFICATION; INOSITOL; MEMBRANE AB Rapid incorporation of exogenous arachidonic acid into phospholipid has been detected in conjunction with eicosanoid synthesis by purified mast cell granules [Chock, S. P. & Schmauder-Chock, E. A. (1988) Biochem. Biophys. Res. Commun. 156, 1308-1315]. The species of phospholipid formed has now been identified primarily as phosphatidylinositol. A calcium-dependent phospholipase A2 has also been detected in the secretory granule. This enzyme, like the cyclooxygenase [Schmauder-Chock, E. A. & Chock, S. P. (1989) J. Histochem. Cytochem. 37, 1319-1328], appears to bind tightly to the granule matrix components. It is heat resistant and requires millimolar concentrations of calcium for optimal activity. It prefers phosphatidylinositol over phosphatidylcholine as substrate. Since the granule contains a large amount of phospholipid, the action of this phospholipase A2 can provide the required substrate for the arachidonic acid cascade. These findings provide the basis for linking phospholipase A2 to the production of eicosanoids during granule exocytosis. Since the granule also contains both an active acylating system that can rapidly reacylate lysophosphatidylinositol to form phosphatidylinositol, and an active phospholipase A2 which hydrolyzes phosphatidylinositol, a rapid turnover involving the fatty acid at the sn-2 position of phosphatidylinositol may occur. These findings are consistent with our postulation that the secretory granule is the source and/or the cause of many of the early biochemical events associated with the process of stimulus-secretion coupling. C1 WALTER REED ARMY MED CTR,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307. NHLBI,BIOCHEM LAB,BETHESDA,MD 20892. ARMED FORCES RADIOBIOL RES INST,DEPT EXPTL HEMATOL,BETHESDA,MD 20814. NR 59 TC 15 Z9 15 U1 0 U2 0 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0014-2956 J9 EUR J BIOCHEM JI Eur. J. Biochem. PD FEB 14 PY 1991 VL 195 IS 3 BP 707 EP 713 DI 10.1111/j.1432-1033.1991.tb15757.x PG 7 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA EY552 UT WOS:A1991EY55200016 PM 1900237 ER PT J AU KERKAM, K VINEY, C KAPLAN, D LOMBARDI, S AF KERKAM, K VINEY, C KAPLAN, D LOMBARDI, S TI LIQUID CRYSTALLINITY OF NATURAL SILK SECRETIONS SO NATURE LA English DT Article ID PHYSICAL-PROPERTIES; FIBROIN; POLYMERS; TEXTURES; MODULATION AB NATURAL silk exhibits a strength and stiffness similar to, and a toughness up to ten times greater than, that of artificial high-performance fibres 1-5. These exceptional tensile properties, the optical birefringence of some silk secretions 6-9 and the molecular order exhibited by some synthetic polypeptides in solution 10 all suggest that natural silk secretions might form liquid-crystalline phases. We have now used polarized-light microscopy to study the secretions from major ampullae of spiders (Nephila clavipes) and from silk glands of silkworms (Bombyx mori). As the concentration is increased by evaporation of water, nematic liquid-crystalline microstructures develop. We deduce that natural silk secretions become liquid crystalline after leaving the gland but before solidifying into a fibre, thus promoting global molecular alignment in the fibre. Our hand-drawn fibres from droplets of secretion, as well as sheared thin films, show a banded microstructure which is indicative of a periodic variation in the direction of molecular alignment. Both B. mori and N. clavipes, on the other hand, have apparently developed processing routes that ensure uniform molecular alignment: the threads and draglines, respectively, of these species do not show banded microstructures. C1 UNIV WASHINGTON, DEPT MAT SCI & ENGN FB10, SEATTLE, WA 98195 USA. USA, CTR RES DEV & ENGN, NATICK, MA 01760 USA. NR 30 TC 129 Z9 140 U1 5 U2 57 PU NATURE PUBLISHING GROUP PI LONDON PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND SN 0028-0836 EI 1476-4687 J9 NATURE JI Nature PD FEB 14 PY 1991 VL 349 IS 6310 BP 596 EP 598 DI 10.1038/349596a0 PG 3 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA EX570 UT WOS:A1991EX57000054 ER PT J AU ZIEGLER, EJ FISHER, CJ SPRUNG, CL STRAUBE, RC SADOFF, JC FOULKE, GE WORTEL, CH FINK, MP DELLINGER, RP TENG, NNH ALLEN, IE BERGER, HJ KNATTERUD, GL LOBUGLIO, AF SMITH, CR AF ZIEGLER, EJ FISHER, CJ SPRUNG, CL STRAUBE, RC SADOFF, JC FOULKE, GE WORTEL, CH FINK, MP DELLINGER, RP TENG, NNH ALLEN, IE BERGER, HJ KNATTERUD, GL LOBUGLIO, AF SMITH, CR TI TREATMENT OF GRAM-NEGATIVE BACTEREMIA AND SEPTIC SHOCK WITH HA-1A HUMAN MONOCLONAL-ANTIBODY AGAINST ENDOTOXIN - A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL SO NEW ENGLAND JOURNAL OF MEDICINE LA English DT Article ID MUTANT ESCHERICHIA-COLI; IGG ANTIBODY; LIPID-A; PROTECTION; SEPSIS; CORE; J5 AB Background. HA-1A is a human monoclonal IgM antibody that binds specifically to the lipid A domain of endotoxin and prevents death in laboratory animals with gram-negative bacteremia and endotoxemia. Methods. To evaluate the efficacy and safety of HA-1A, we conducted a randomized, double-blind trial in patients with sepsis and a presumed diagnosis of gram-negative infection. The patients received either a single 100-mg intravenous dose of HA-1A (in 3.5 g of albumin) or placebo (3.5 g of albumin). Other interventions, including the administration of antibiotics and fluids, were not affected by the study protocol. Results. Of 543 patients with sepsis who were treated, 200 (37 percent) had gram-negative bacteremia as proved by blood culture. For the patients with gram-negative bacteremia followed to death or day 28, there were 45 deaths among the 92 recipients of placebo (49 percent) and 32 deaths among the 105 recipients of HA-1A (30 percent; P = 0.014). For the patients with gram-negative bacteremia and shock at entry, there were 27 deaths among the 47 recipients of placebo (57 percent) and 18 deaths among the 54 recipients of HA-1A (33 percent; P = 0.017). Analyses that stratified according to the severity of illness at entry showed improved survival with HA-1A treatment in both severely ill and less severely ill patients. Of the 196 patients with gram-negative bacteremia who were followed to hospital discharge or death, 45 of the 93 given placebo (48 percent) were discharged alive, as compared with 65 of the 103 treated with HA-1A (63 percent; P = 0.038). No benefit of treatment with HA-1A was demonstrated in the 343 patients with sepsis who did not prove to have gram-negative bacteremia. For all 543 patients with sepsis who were treated, the mortality rate was 43 percent among the recipients of placebo and 39 percent among those given HA-1A (P = 0.24). All patients tolerated HA-1A well, and no anti-HA-1A antibodies were detected. Conclusions. HA-1A is safe and effective for the treatment of patients with sepsis and gram-negative bacteremia. C1 UNIV HOSP CLEVELAND,CTR CRIT CARE RES,DIV PULM & CRIT CARE MED,2074 ABINGTON RD,CLEVELAND,OH 44106. UNIV CALIF SAN DIEGO,DEPT MED,SAN DIEGO,CA 92103. CASE WESTERN RESERVE UNIV,DEPT MED,CLEVELAND,OH 44106. UNIV MIAMI,DEPT MED,MIAMI,FL 33152. CENTOCOR INC,DIV RES & DEV,MALVERN,PA. WALTER REED ARMY MED CTR,DEPT BACTERIAL DIS,WASHINGTON,DC 20307. UNIV CALIF DAVIS,SACRAMENTO MED CTR,DEPT MED,SACRAMENTO,CA 95817. UNIV AMSTERDAM,ACAD MED CTR,CTR HEMOSTASIS THROMBOSIS & ATHEROSCLEROSIS RES,1105 AZ AMSTERDAM,NETHERLANDS. UNIV AMSTERDAM,ACAD MED CTR,DEPT INTENS CARE,1105 AZ AMSTERDAM,NETHERLANDS. UNIV MASSACHUSETTS,DEPT SURG,WORCESTER,MA 01605. BAYLOR UNIV,DEPT MED,HOUSTON,TX 77030. STANFORD UNIV,DEPT OBSTET & GYNECOL,STANFORD,CA 94305. STANFORD UNIV,CANC BIOL RES LAB,STANFORD,CA 94305. MARYLAND MED RES INST,BALTIMORE,MD. UNIV ALABAMA,DEPT MED,BIRMINGHAM,AL 35294. NR 25 TC 1215 Z9 1228 U1 4 U2 20 PU MASS MEDICAL SOC PI BOSTON PA 10 SHATTUCK, BOSTON, MA 02115 SN 0028-4793 J9 NEW ENGL J MED JI N. Engl. J. Med. PD FEB 14 PY 1991 VL 324 IS 7 BP 429 EP 436 DI 10.1056/NEJM199102143240701 PG 8 WC Medicine, General & Internal SC General & Internal Medicine GA EX363 UT WOS:A1991EX36300001 PM 1988827 ER PT J AU SMITH, RT ZOLTANI, CK KLEM, GJ COLEMAN, MW AF SMITH, RT ZOLTANI, CK KLEM, GJ COLEMAN, MW TI RECONSTRUCTION OF TOMOGRAPHIC-IMAGES FROM SPARSE DATA SETS BY A NEW FINITE-ELEMENT MAXIMUM-ENTROPY APPROACH SO APPLIED OPTICS LA English DT Article AB A new algorithm for the reconstruction of tomographic images from sparse data sets is presented. A finite element technique was devised to solve the constrained optimization problem which resulted from the analysis using the maximum entropy formalism. The improvement in reconstruction image quality over conventional techniques is illustrated by several examples. C1 USA,BALLIST RES LAB,ABERDEEN PROVING GROUND,MD 21006. RP SMITH, RT (reprint author), MILLERSVILLE UNIV,DEPT MATH,MILLERSVILLE,PA 17551, USA. NR 13 TC 20 Z9 21 U1 0 U2 1 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0003-6935 J9 APPL OPTICS JI Appl. Optics PD FEB 10 PY 1991 VL 30 IS 5 BP 573 EP 582 PG 10 WC Optics SC Optics GA EW645 UT WOS:A1991EW64500007 PM 20582027 ER PT J AU DECUSATIS, C DAS, P LITYNSKI, DM AF DECUSATIS, C DAS, P LITYNSKI, DM TI ACOUSTO-ELECTRO-OPTIC PHASE GRATINGS FOR OPTICAL SIGNAL-PROCESSING APPLICATIONS SO APPLIED OPTICS LA English DT Article ID MODULATION AB Electrooptic and acoustooptic phase gratings perform many useful operations and often compete with each other for similar applications. Using piezoelectric crystals, it is possible to generate a simultaneous acousto-electro-optic (AEO) grating, which has advantages over applying either effect separately. The AEO effect using surface acoustic waves and electrooptic interdigital transducers is discussed. Coupled mode theory has been used to analyze the resulting diffraction effects, and experimental results in both the Bragg and Raman-Nath regimes are reported. The device can perform fundamental operations such as convolution, correlation, and optical matrix processing. We propose AEO components for use in spread spectrum systems, hybrid optical bistability, and adaptive phased array antenna control. C1 US MIL ACAD,DEPT ELECT ENGN,W POINT,NY 10996. RENSSELAER POLYTECH INST,DEPT ELECT COMP & SYST ENGN,TROY,NY 12180. RP DECUSATIS, C (reprint author), IBM CORP,DIV DATA SYST,MS 463,NEIGHBORHOOD RD,KINGSTON,NY 12401, USA. NR 28 TC 4 Z9 4 U1 0 U2 1 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0003-6935 J9 APPL OPTICS JI Appl. Optics PD FEB 10 PY 1991 VL 30 IS 5 BP 583 EP 596 PG 14 WC Optics SC Optics GA EW645 UT WOS:A1991EW64500008 PM 20582028 ER PT J AU HOWARD, SL AF HOWARD, SL TI CHARGE-TRANSFER REACTION OF HELIUM-IONS WITH NITROGEN SO CHEMICAL PHYSICS LETTERS LA English DT Article ID LASER-INDUCED FLUORESCENCE; CROSSED-BEAM; ENERGIES; N-2 AB The charge-transfer reaction of helium ions with nitrogen molecules was investigated in order to gain insight into the role of vibrational-energy transfer in reaction dynamics. This paper presents kinematic data at moderate energies of the charge-transfer reaction of He+ with N2(X 1-SIGMA-g+, upsilon = 0). The preferred reaction channels were formation of electronically excited N2+ (A 2-PI-u+) via a direct mechanism and from highly scattered ground-state N2+ (X 2-SIGMA-g+, upsilon = 0-4) with contribution from N2+ (B 2-SIGMA-u+) produced via impulsive mechanism. RP HOWARD, SL (reprint author), USA,BALLIST RES LABS,ABERDEEN PROVING GROUND,MD 21005, USA. NR 13 TC 1 Z9 1 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0009-2614 J9 CHEM PHYS LETT JI Chem. Phys. Lett. PD FEB 8 PY 1991 VL 177 IS 1 BP 1 EP 3 DI 10.1016/0009-2614(91)90165-6 PG 3 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA EZ614 UT WOS:A1991EZ61400001 ER PT J AU FUNG, KY CARR, LW AF FUNG, KY CARR, LW TI EFFECTS OF COMPRESSIBILITY ON DYNAMIC STALL SO AIAA JOURNAL LA English DT Note C1 NASA,AMES RES CTR,USA,AEROFLIGHTDYNAM DIRECTORATE,MOFFETT FIELD,CA 94035. NASA,AMES RES CTR,FLUID DYNAM RES BRANCH,MOFFETT FIELD,CA 94035. RP FUNG, KY (reprint author), UNIV ARIZONA,DEPT AEROSP & MECH ENGN,TUCSON,AZ 85721, USA. NR 13 TC 4 Z9 4 U1 0 U2 0 PU AMER INST AERONAUT ASTRONAUT PI RESTON PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091 SN 0001-1452 J9 AIAA J JI AIAA J. PD FEB PY 1991 VL 29 IS 2 BP 306 EP 308 DI 10.2514/3.10578 PG 3 WC Engineering, Aerospace SC Engineering GA FA441 UT WOS:A1991FA44100019 ER PT J AU SOMMERVILLE, DR AF SOMMERVILLE, DR TI CRITICAL TRANSPORT VELOCITY IN 2-PHASE, HORIZONTAL PIPE-FLOW SO AICHE JOURNAL LA English DT Note ID SLURRIES RP SOMMERVILLE, DR (reprint author), USA,CTR CHEM RES DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010, USA. NR 10 TC 2 Z9 2 U1 0 U2 0 PU AMER INST CHEMICAL ENGINEERS PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 SN 0001-1541 J9 AICHE J JI AICHE J. PD FEB PY 1991 VL 37 IS 2 BP 274 EP 276 DI 10.1002/aic.690370214 PG 3 WC Engineering, Chemical SC Engineering GA EX550 UT WOS:A1991EX55000013 ER PT J AU REDFIELD, R BIRX, D POLONIS, V DAVIS, C VIRANI, N JOHNSON, S SHAFFERMAN, A SMITH, G OSTER, C TRAMONT, E BURKE, D AF REDFIELD, R BIRX, D POLONIS, V DAVIS, C VIRANI, N JOHNSON, S SHAFFERMAN, A SMITH, G OSTER, C TRAMONT, E BURKE, D TI ACTIVE IMMUNIZATION OF RECOMBINANT PRODUCED GP-160 IN PATIENTS WITH EARLY HIV-INFECTION - PHASE-1 TRIAL IMMUNOGENICITY AND TOXICITY SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,DIV RETROVIROL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD FEB PY 1991 VL 7 IS 2 BP 136 EP 136 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA EY300 UT WOS:A1991EY30000024 ER PT J AU BENVENISTE, R HEIDECKER, G HENDERSON, L POWELL, P LEWIS, M HU, SL MORTON, W EDDY, G BURKE, D SHAFFERMAN, A AF BENVENISTE, R HEIDECKER, G HENDERSON, L POWELL, P LEWIS, M HU, SL MORTON, W EDDY, G BURKE, D SHAFFERMAN, A TI PATHOGENESIS AND VACCINE STUDIES IN SIV AND TYPE D RETROVIRUS-INFECTED MACAQUES SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract C1 NCI,BETHESDA,MD 20892. PROGRAM RESOURCES INC,FREDERICK,MD. USA,MED RES INST INFECT DIS,FREDERICK,MD 21701. ONCOGEN,SEATTLE,WA. WASHINGTON PRIMATE RES CTR,SEATTLE,WA. JACKSON FDN,RES LAB,ROCKVILLE,MD. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. ISRAEL INST BIOL RES,IL-70450 NESS ZIONA,ISRAEL. RI Hu, Shiu-Lok/A-3196-2008 OI Hu, Shiu-Lok/0000-0003-4336-7964 NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD FEB PY 1991 VL 7 IS 2 BP 159 EP 160 PG 2 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA EY300 UT WOS:A1991EY30000066 ER PT J AU LEWIS, MG BIRX, DL ZACK, PM VAHEY, MA REDFIELD, RR BURKE, DS JAHRLING, PB AF LEWIS, MG BIRX, DL ZACK, PM VAHEY, MA REDFIELD, RR BURKE, DS JAHRLING, PB TI ELEVATED LEVELS OF CIRCULATING INTERLEUKIN-6 ARE ASSOCIATED WITH INFECTION WITH AN ACUTELY FATAL SIMIAN IMMUNODEFICIENCY VIRUS ISOLATE (SIVSM/PBJ) SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract C1 USA,MED RES INST INFECT DIS,SO RES INST,FREDERICK,MD 21701. USA,MED RES INST INFECT DIS,DIV DIS ASSESSMENT,FREDERICK,MD 21701. WRAIR,DIV RETROVIROL,ROCKVILLE,MD 20850. NR 0 TC 1 Z9 1 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD FEB PY 1991 VL 7 IS 2 BP 163 EP 163 PG 1 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA EY300 UT WOS:A1991EY30000072 ER PT J AU MICHAEL, NL MORROW, P VAHEY, MT MOSCA, J REDFIELD, RR AF MICHAEL, NL MORROW, P VAHEY, MT MOSCA, J REDFIELD, RR TI INDUCTION OF HIV-1 EXPRESSION IN CHRONICALLY-INFECTED CELLS IS ASSOCIATED PRIMARILY WITH A SHIFT IN RNA SPLICING SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,DEPT RETROVIRAL RES,ROCKVILLE,MD 20850. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD FEB PY 1991 VL 7 IS 2 BP 182 EP 183 PG 2 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA EY300 UT WOS:A1991EY30000109 ER PT J AU DUNN, JF AF DUNN, JF TI OSGOOD-SCHLATTER DISEASE - REPLY SO AMERICAN FAMILY PHYSICIAN LA English DT Letter RP DUNN, JF (reprint author), USA,HLTH CLIN,FT MCPHERSON,GA, USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU AMER ACAD FAMILY PHYSICIANS PI KANSAS CITY PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 SN 0002-838X J9 AM FAM PHYSICIAN JI Am. Fam. Physician PD FEB PY 1991 VL 43 IS 2 BP 405 EP 405 PG 1 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA EV963 UT WOS:A1991EV96300005 ER PT J AU ROBERTSON, WG AF ROBERTSON, WG TI EARLY,JUBAL RAID ON WASHINGTON, 1864 - COOLING,BF SO AMERICAN HISTORICAL REVIEW LA English DT Book Review RP ROBERTSON, WG (reprint author), USA COMMAND & GEN STAFF COLL,FT LEAVENWORTH,KS 66027, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU AMER HISTORICAL REVIEW PI WASHINGTON PA 400 A ST SE, WASHINGTON, DC 20003 SN 0002-8762 J9 AM HIST REV JI Am. Hist. Rev. PD FEB PY 1991 VL 96 IS 1 BP 264 EP 265 DI 10.2307/2164217 PG 2 WC History SC History GA EZ341 UT WOS:A1991EZ34100204 ER PT J AU BILELLO, JF OHAIR, KC KIRBY, WC MOORE, JW AF BILELLO, JF OHAIR, KC KIRBY, WC MOORE, JW TI INTRAOSSEOUS INFUSION OF DOBUTAMINE AND ISOPROTERENOL SO AMERICAN JOURNAL OF DISEASES OF CHILDREN LA English DT Article AB Intraosseous infusion has been advocated as an emergency route in sick infants and children when intravenous access is not readily obtainable. Dobutamine hydrochloride and isoproterenol hydrochloride are useful emergency drugs that have been studied when administered into the bone marrow. In a swine model, we compared the physiologic responses (heart rate, arterial pressure, and cardiac output) of dobutamine and isoproterenol infusions delivered intravenously and intraosseously during 20-minute intervals. We observed statistically significant effects of both dobutamine and isoproterenol delivered by the intraosseous route. In addition, the effects resulting from intraosseous infusion were statistically similar to those resulting from intravenous administration of these drugs. We conclude that the intraosseous infusion of dobutamine and isoproterenol is an effective and useful method for emergency administration of these medications. C1 WALTER REED ARMY MED CTR,PEDIAT CARDIOL SECT,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT PEDIAT,WASHINGTON,DC 20307. WILLIAM BEAUMONT ARMY MED CTR,DEPT PEDIAT,EL PASO,TX 79920. WILLIAM BEAUMONT ARMY MED CTR,DEPT CLIN INVEST,EL PASO,TX 79920. NR 24 TC 8 Z9 8 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0002-922X J9 AM J DIS CHILD JI Am. J. Dis. Child. PD FEB PY 1991 VL 145 IS 2 BP 165 EP 167 PG 3 WC Pediatrics SC Pediatrics GA EX226 UT WOS:A1991EX22600013 PM 1994681 ER PT J AU CHILDS, JE GLASS, GE KSIAZEK, TG ROSSI, CA ORO, JGB LEDUC, JW AF CHILDS, JE GLASS, GE KSIAZEK, TG ROSSI, CA ORO, JGB LEDUC, JW TI HUMAN-RODENT CONTACT AND INFECTION WITH LYMPHOCYTIC CHORIOMENINGITIS AND SEOUL VIRUSES IN AN INNER-CITY POPULATION SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID HEMORRHAGIC-FEVER; RAT-POPULATIONS; HANTAAN VIRUS; UNITED-STATES; BALTIMORE; MARYLAND; HANTAVIRUS; ANTIBODY AB We collected 1180 sera and 1363 questionnaires with information on demography, rodent exposure, and history of travel from persons visiting a sexually transmitted disease (STD) clinic in Baltimore between 1986-1988. Serological tests for two rodent-borne viruses detected antibodies to lymphocytic choriomeningitis virus (LCMV) in 54 individuals (4.70%; n = 1149) and antibodies to Seoul virus (SEOV) in three persons (0.25%; n = 1180). Antibody prevalence to LCMV increased with age, but there were no racial or sexual differences. Neutralization tests and questionnaire responses implicated a domestic, rat-borne hantavirus as the source of SEOV antibody. Self-reported human-rodent contact indicated more exposure to house mice than rats within residences, although rats were more commonly sighted on streets. Infections with rodent-borne viruses were rare compared to the high rates of reported contact. C1 USA,MED RES INST INFECT DIS,DIV DIS ASSESSMENT,FREDERICK,MD 21701. SALK INST,DIV GOVT SERV,SWIFTWATER,PA. RP CHILDS, JE (reprint author), JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,DEPT IMMUNOL & INFECT DIS,615 N WOLFE,BALTIMORE,MD 21205, USA. RI Childs, James/B-4002-2012 NR 22 TC 77 Z9 81 U1 0 U2 2 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD FEB PY 1991 VL 44 IS 2 BP 117 EP 121 PG 5 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA FF797 UT WOS:A1991FF79700001 PM 1672798 ER PT J AU GRANT, CL HEWITT, AD JENKINS, TF AF GRANT, CL HEWITT, AD JENKINS, TF TI EXPERIMENTAL COMPARISON OF EPA AND USATHAMA DETECTION AND QUANTITATION CAPABILITY ESTIMATORS SO AMERICAN LABORATORY LA English DT Article ID DETECTION LIMITS AB This paper examines the compatibility of two common estimators of low concentration measurement capability for environmental studies: the method detection limit (MDL) specified by the U.S. EPA, and the certified reporting limit (CRL) specified by the U.S. Army Toxic and Hazardous Materials Agency (USATHAMA). C1 USA,COLD REG RES & ENGN LAB,GEOCHEM SCI BRANCH,HANOVER,NH 03755. RP GRANT, CL (reprint author), UNIV NEW HAMPSHIRE,DEPT CHEM,DURHAM,NH 03824, USA. NR 18 TC 21 Z9 21 U1 0 U2 0 PU INT SCIENTIFIC COMMUN INC PI SHELTON PA PO BOX 870, 30 CONTROLS DRIVE, SHELTON, CT 06484-0870 SN 0044-7749 J9 AM LAB JI Am. Lab. PD FEB PY 1991 VL 23 IS 3 BP 15 EP 33 PG 19 WC Chemistry, Analytical; Instruments & Instrumentation SC Chemistry; Instruments & Instrumentation GA EW751 UT WOS:A1991EW75100001 ER PT J AU HEYES, MP BREW, BJ MARTIN, A PRICE, RW SALAZAR, AM SIDTIS, JJ YERGEY, JA MOURADIAN, MM SADLER, AE KEILP, J RUBINOW, D MARKEY, SP AF HEYES, MP BREW, BJ MARTIN, A PRICE, RW SALAZAR, AM SIDTIS, JJ YERGEY, JA MOURADIAN, MM SADLER, AE KEILP, J RUBINOW, D MARKEY, SP TI QUINOLINIC ACID IN CEREBROSPINAL-FLUID AND SERUM IN HIV-1 INFECTION - RELATIONSHIP TO CLINICAL AND NEUROLOGICAL STATUS SO ANNALS OF NEUROLOGY LA English DT Article ID AIDS DEMENTIA COMPLEX; METHYL-D-ASPARTATE; IMMUNE-DEFICIENCY SYNDROME; CENTRAL NERVOUS-SYSTEM; RAT-BRAIN; HUNTINGTONS-DISEASE; ALZHEIMERS-DISEASE; TRYPTOPHAN; BLOOD AB Quinolinic acid is an "excitotoxic" metabolite and an agonist of N-methyl-D-aspartate receptors. Of patients infected with human immunodeficiency virus type 1 (HIV-1) who were neurologically normal or exhibited only equivocal and subclinical signs of the acquired immunodeficiency syndrome (AIDS) dementia complex, concentrations of quinolinic acid in cerebrospinal fluid (CSF) were increased twofold in patients in the early stages of disease (Walter Reed stages 1 and 2) and averaged 3.8 times above normal in later-stage patients (Walter Reed stages 4 through 6). However, in patients with either clinically overt AIDS dementia complex, aseptic meningitis, opportunistic infections, or neoplasms, CSF levels were elevated over 20-fold and generally paralleled the severity of cognitive and motor dysfunction. CSF concentrations of quinolinic acid were significantly correlated to the severity of the neuropsychological deficits. After treatment of AIDS dementia complex with zidovudine and treatment of the opportunistic infections with specific antimicrobial therapies, CSF levels of quinolinic acid decreased in parallel with clinical neurological improvement. By analysis of the relationship between levels of quinolinic acid in the CSF and serum and integrity of the blood-brain barrier, as measured by the CSF: serum albumin ratio, it appears that CSF levels of quinolinic acid may be derived predominantly from intracerebral sources and perhaps from the serum. While quinolinic acid may be another "marker" of host- and virus-mediated events in the brain, the established excitotoxic effects of quinolinic acid and the magnitude of the increases in CSF levels of the acid raise the possibility that quinolinic acid plays a direct role in the pathogenesis of brain dysfunction associated with HIV-1 infection. C1 NIMH,BIOL PSYCHIAT BRANCH,BETHESDA,MD 20892. MEM SLOAN KETTERING CANC CTR,DEPT NEUROL,NEW YORK,NY 10021. MIL MED CONSORTIUM APPL RETROVIRUS RES,WASHINGTON,DC. NIAAA,CLIN SCI LAB,ANALYT CHEM SECT,ROCKVILLE,MD 20852. NINCDS,EXPTL THERAPEUT BRANCH,BETHESDA,MD 20892. UNIFORM SERV UNIV HLTH SCI,WALTER REED ARMY MED CTR,DEPT NEUROL,WASHINGTON,DC. RP HEYES, MP (reprint author), NIMH,CLIN SCI LAB,ANALYT BIOCHEM SECT,BLDG 10,ROOM 3D40,BETHESDA,MD 20892, USA. RI martin, alex/B-6176-2009; Brew, Bruce/J-6513-2012; OI Mouradian, M. Maral/0000-0002-9937-412X FU NINDS NIH HHS [NS-25701] NR 35 TC 520 Z9 529 U1 3 U2 7 PU LITTLE BROWN CO PI BOSTON PA 34 BEACON STREET, BOSTON, MA 02108-1493 SN 0364-5134 J9 ANN NEUROL JI Ann. Neurol. PD FEB PY 1991 VL 29 IS 2 BP 202 EP 209 DI 10.1002/ana.410290215 PG 8 WC Clinical Neurology; Neurosciences SC Neurosciences & Neurology GA EW939 UT WOS:A1991EW93900014 PM 1826418 ER PT J AU BARTLETT, MS QUEENER, SF TIDWELL, RR MILHOUS, WK BERMAN, JD ELLIS, WY SMITH, JW AF BARTLETT, MS QUEENER, SF TIDWELL, RR MILHOUS, WK BERMAN, JD ELLIS, WY SMITH, JW TI 8-AMINOQUINOLINES FROM WALTER-REED-ARMY-INSTITUTE FOR RESEARCH FOR TREATMENT AND PROPHYLAXIS OF PNEUMOCYSTIS PNEUMONIA IN RAT MODELS SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY LA English DT Article ID CARINII PNEUMONIA; CLINDAMYCIN; PRIMAQUINE; EFFICACY AB Three 8-aminoquinolines from the Walter Reed Army Institute for Research (WRAIR), WR6026, WR238605, and WR242511, strongly inhibited Pneumocystis carinii growth in vitro at 1-mu-g/ml. This activity was similar to that of primaquine. In rat therapy models, the WRAIR compounds affected Pneumocystis pneumonia at doses as low as 0.25 mg/kg (WR242511) or 0.5 mg/kg (WR6026 and WR238605). At these doses, primaquine alone was ineffective as therapy. In a rat prophylaxis model, all three WRAIR 8-aminoquinolines were extremely effective at daily doses of 0.57 mg/kg, showing activity greater than that of primaquine at this dosage and comparable to that of trimethoprim-sulfamethoxazole at 50/250 mg/kg. C1 UNIV N CAROLINA,CHAPEL HILL,NC 27599. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. RP BARTLETT, MS (reprint author), INDIANA UNIV,SCH MED,INDIANAPOLIS,IN 46202, USA. FU NIAID NIH HHS [N01-AI-72647, N01-AI-72648, UO1-AI-25859] NR 13 TC 44 Z9 44 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0066-4804 J9 ANTIMICROB AGENTS CH JI Antimicrob. Agents Chemother. PD FEB PY 1991 VL 35 IS 2 BP 277 EP 282 PG 6 WC Microbiology; Pharmacology & Pharmacy SC Microbiology; Pharmacology & Pharmacy GA EV742 UT WOS:A1991EV74200014 PM 2024961 ER PT J AU BARNETT, BB BURNS, NJ PARK, KJ DAWSON, MI KENDE, M SIDWELL, RW AF BARNETT, BB BURNS, NJ PARK, KJ DAWSON, MI KENDE, M SIDWELL, RW TI ANTIVIRAL IMMUNOTOXINS - ANTIBODY-MEDIATED DELIVERY OF GELONIN INHIBITS PICHINDE VIRUS-REPLICATION INVITRO SO ANTIVIRAL RESEARCH LA English DT Article DE IMMUNOTOXIN; GELONIN; PICHINDE VIRUS; ANTIVIRAL; ARENAVIRUS; TARGETED DELIVERY ID INACTIVATING PROTEINS GELONIN; HIV-INFECTED CELLS; MONOCLONAL-ANTIBODY; A-CHAIN; CONJUGATE; INVIVO AB Immunotoxins were produced and evaluated for antiviral activity against Pichinde virus, a member of the family Arenaviridae. Immunoglobulins were conjugated to the ribosome-inactivating protein, gelonin, through a disulfide linkage to form the immunotoxins. Immunotoxins were produced utilizing monoclonal antibodies, immunoglobulin-binding proteins and hyperimmune sera. An immunotoxin consisting of hyperimmune rabbit sera conjugated with gelonin displayed strong antiviral activity against Pichinde virus, as did a protein G-gelonin indirect immunotoxin in combination with nonconjugated hyperimmune sera. Hyperimmune rabbit sera conjugated with gelonin caused no detectable cytotoxicity in noninfected Vero cells as measured by [H-3]leucine incorporation. The 50% effective dose for the immunotoxin was 0.018-mu-M compared with 86-mu-M for ribavirin. C1 UTAH STATE UNIV,DEPT ANIM DAIRY & VET SCI,LOGAN,UT 84322. SRI INT,MENLO PK,CA 94025. CTR INFECT DIS,FT COLLINS,CO. USA,MED RES INST INFECT DIS,FREDERICK,MD 21701. RP BARNETT, BB (reprint author), UTAH STATE UNIV,DEPT BIOL,LOGAN,UT 84322, USA. NR 22 TC 14 Z9 14 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-3542 J9 ANTIVIR RES JI Antiviral Res. PD FEB PY 1991 VL 15 IS 2 BP 125 EP 138 DI 10.1016/0166-3542(91)90030-U PG 14 WC Pharmacology & Pharmacy; Virology SC Pharmacology & Pharmacy; Virology GA FE419 UT WOS:A1991FE41900004 PM 1650165 ER PT J AU HURST, CJ SCHAUB, SA SOBSEY, MD FARRAH, SR GERBA, CP ROSE, JB GOYAL, SM LARKIN, EP SULLIVAN, R TIERNEY, JT OBRIEN, RT SAFFERMAN, RS MORRIS, ME WELLINGS, FM LEWIS, AL BERG, G BRITTON, PW WINTER, JA AF HURST, CJ SCHAUB, SA SOBSEY, MD FARRAH, SR GERBA, CP ROSE, JB GOYAL, SM LARKIN, EP SULLIVAN, R TIERNEY, JT OBRIEN, RT SAFFERMAN, RS MORRIS, ME WELLINGS, FM LEWIS, AL BERG, G BRITTON, PW WINTER, JA TI MULTILABORATORY EVALUATION OF METHODS FOR DETECTING ENTERIC VIRUSES IN SOILS SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY LA English DT Article ID WASTE-WATER; SURVIVAL; ENTEROVIRUSES; SLUDGE AB Two candidate methods for the recovery and detection of viruses in soil were subjected to round robin comparative testing by members of the American Society for Testing and Materials D19:24:04:04 Subcommittee Task Group. Selection of the methods, designated ''Berg'' and ''Goyal,'' was based on results of an initial screening which indicated that both met basic criteria considered essential by the task group. Both methods utilized beef extract solutions to achieve desorption and recovery of viruses from representative soils: a fine sand soil, an organic muck soil, a sandy loam soil, and a clay loam soil. One of the two methods, Goyal, also used a secondary concentration of resulting soil eluant via low-pH organic flocculation to achieve a smaller final assay volume. Evaluation of the two methods was simultaneously performed in replicate by nine different laboratories. Each of the produced samples was divided into portions, and these were respectively subjected to quantitative viral plaque assay by both the individual, termed independent, laboratory which had done the soil processing and a single common reference laboratory, using a single cell line and passage level. The Berg method seemed to produce slightly higher virus recovery values; however, the differences in virus assay titers for samples produced by the two methods were not statistically significant (P less-than-or-equal-to 0.05) for any one of the four soils. Despite this lack of a method effect, there was a statistically significant laboratory effect exhibited by assay titers from the independent versus reference laboratories for two of the soils, sandy loam and clay loam. C1 UNIV CINCINNATI,DEPT CIVIL & ENVIRONM ENGN,CINCINNATI,OH 45221. US FDA,CINCINNATI,OH 45226. EPIDEMIOL RES CTR,TAMPA,FL 33614. UNIV MINNESOTA,COLL VET MED,VET DIAGNOST LAB,ST PAUL,MN 55108. UNIV ARIZONA,DEPT MICROBIOL & IMMUNOL,TUCSON,AZ 85721. UNIV N CAROLINA,DEPT ENVIRONM SCI & ENGN,CHAPEL HILL,NC 27514. USA,BIOMED RES & DEV LAB,FREDERICK,MD 21701. UNIV FLORIDA,DEPT MICROBIOL,GAINESVILLE,FL 32611. NEW MEXICO STATE UNIV,DEPT BIOL,LAS CRUCES,NM 88003. RP HURST, CJ (reprint author), US EPA,CINCINNATI,OH 45268, USA. NR 10 TC 8 Z9 8 U1 0 U2 1 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0099-2240 J9 APPL ENVIRON MICROB JI Appl. Environ. Microbiol. PD FEB PY 1991 VL 57 IS 2 BP 395 EP 401 PG 7 WC Biotechnology & Applied Microbiology; Microbiology SC Biotechnology & Applied Microbiology; Microbiology GA EV647 UT WOS:A1991EV64700010 PM 1849712 ER PT J AU MCNESBY, KL CHABALOWSKI, CF FIFER, RA AF MCNESBY, KL CHABALOWSKI, CF FIFER, RA TI APPROXIMATION TO TRUE PEAK ABSORBENCY FROM OBSERVED PEAK ABSORBENCY FOR GAS-PHASE FOURIER-TRANSFORM SPECTROSCOPY SO APPLIED OPTICS LA English DT Article AB We have developed an approximation that provides a fast reasonably accurate estimate of the halfwidth at halfheight of a single pressure-broadened line. RP MCNESBY, KL (reprint author), USA,BALLIST RES LABS,ABERDEEN PROVING GROUND,MD 21005, USA. NR 4 TC 0 Z9 0 U1 0 U2 0 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0003-6935 J9 APPL OPTICS JI Appl. Optics PD FEB 1 PY 1991 VL 30 IS 4 BP 378 EP 379 PG 2 WC Optics SC Optics GA EW644 UT WOS:A1991EW64400009 PM 20581999 ER PT J AU WILLIAMS, DH COGAN, JL AF WILLIAMS, DH COGAN, JL TI ESTIMATION OF VISIBILITY FROM SATELLITE IMAGERY SO APPLIED OPTICS LA English DT Article ID SURFACE ALBEDO; CONTRAST REDUCTION; ATMOSPHERE; SCATTERING; RETRIEVAL; AFRICA AB This work examines methods for estimating visibility from satellite imagery, which employ information from the spatial and frequency domains. Properties of luminance and contrast images are derived and compared in both domains. In the past, contrast has traditionally been employed to measure the effects of atmospheric attenuation on visibility. However, the derived results show that the luminance image in either domain contains all the necessary information to calculate standard visibility parameters. Two methods are presented which estimate representative parameters. C1 USA,ATMOSPHER SCI LAB,WHITE SANDS MISSILE RANGE,NM 88002. RP WILLIAMS, DH (reprint author), UNIV TEXAS,DEPT ELECT ENGN,EL PASO,TX 79968, USA. NR 20 TC 3 Z9 3 U1 0 U2 1 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0003-6935 J9 APPL OPTICS JI Appl. Optics PD FEB 1 PY 1991 VL 30 IS 4 BP 414 EP 419 PG 6 WC Optics SC Optics GA EW644 UT WOS:A1991EW64400017 PM 20582007 ER PT J AU JOHNSON, RA STANLEY, AE AF JOHNSON, RA STANLEY, AE TI GC MS AND FT-IR SPECTRA OF METHOXYMETHANOL SO APPLIED SPECTROSCOPY LA English DT Article DE LASER; GC MS; GC FT-IR; LIGHTPIPE ID PULSED HF; METHANOL; LASER; DECOMPOSITION; PHOTOLYSIS AB In the course of recent investigations of the laser-induced reactions of the alkyl alcohols, irradiations of methanol in the gas phase with a carbon dioxide (infrared) laser produced very interesting results. The principal product of the reaction, formaldehyde, spontaneously reacted with excess methanol to form methoxymethanol, a molecule about which very little is known. Initially, due to the presence of excess reactant still in the sample cell, the infrared spectra displayed the bands of the mixtures of both methanol and methoxymethanol, enabling this laboratory to report only the combined infrared spectra with three infrared bands assigned to methoxymethanol. Additional research utilizing hyphenated chromatographic/spectroscopic techniques significantly advanced this effort. A gas chromatograph interfaced with a mass selective detector (GC/MS) and another gas chromatograph interfaced to a gold-plated lightpipe (GC/FT-IR) enabled the recording of both mass and infrared spectra, respectively. After extensive and innovative research efforts, which included the use of novel subambient temperature lightpipe studies, this laboratory recorded the infrared spectra of isolated methoxymethanol, a scientific first. Research in this area is ongoing. This paper reports the experimental parameters and techniques as well as infrared and mass spectra of all molecules investigated, including methoxymethanol, formaldehyde, and methanol, including one deuterated species. C1 USA,MISSILE COMMAND,AMSMI RD WS CM,HUNTSVILLE,AL 35898. NR 17 TC 11 Z9 11 U1 3 U2 11 PU SOC APPLIED SPECTROSCOPY PI FREDERICK PA PO BOX 1438, FREDERICK, MD 21701 SN 0003-7028 J9 APPL SPECTROSC JI Appl. Spectrosc. PD FEB PY 1991 VL 45 IS 2 BP 218 EP 222 DI 10.1366/0003702914337551 PG 5 WC Instruments & Instrumentation; Spectroscopy SC Instruments & Instrumentation; Spectroscopy GA EX852 UT WOS:A1991EX85200013 ER PT J AU WRIGHT, DC LENNOX, JL JAMES, WD OSTER, CN TRAMONT, EC AF WRIGHT, DC LENNOX, JL JAMES, WD OSTER, CN TRAMONT, EC TI GENERALIZED CHRONIC DERMATOPHYTOSIS IN PATIENTS WITH HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-I INFECTION AND CD4 DEPLETION SO ARCHIVES OF DERMATOLOGY LA English DT Letter RP WRIGHT, DC (reprint author), WALTER REED ARMY MED CTR, DEPT MED, DERMATOL SERV, WALTER REED RETROVIRUS RES GRP, WASHINGTON, DC 20307 USA. RI Lennox, Jeffrey/D-1654-2014 OI Lennox, Jeffrey/0000-0002-2064-5565 NR 5 TC 0 Z9 0 U1 0 U2 1 PU AMER MEDICAL ASSOC PI CHICAGO PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA SN 0003-987X EI 1538-3652 J9 ARCH DERMATOL JI Arch. Dermatol. PD FEB PY 1991 VL 127 IS 2 BP 265 EP 266 DI 10.1001/archderm.127.2.265 PG 2 WC Dermatology SC Dermatology GA EX080 UT WOS:A1991EX08000022 ER PT J AU SINOFF, SE AF SINOFF, SE TI SEIZURES FOLLOWING CAROTID ENDARTERECTOMY SO ARCHIVES OF NEUROLOGY LA English DT Letter RP SINOFF, SE (reprint author), WALTER REED ARMY MED CTR, NEUROL SERV, WASHINGTON, DC 20307 USA. NR 8 TC 0 Z9 0 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60654-0946 USA SN 0003-9942 J9 ARCH NEUROL-CHICAGO JI Arch. Neurol. PD FEB PY 1991 VL 48 IS 2 BP 131 EP 131 PG 1 WC Clinical Neurology SC Neurosciences & Neurology GA EX214 UT WOS:A1991EX21400001 PM 1993002 ER PT J AU ROBBINS, SH CONLY, MA OETTINGER, J AF ROBBINS, SH CONLY, MA OETTINGER, J TI COLD-INDUCED GRANULOCYTE AGGLUTINATION - A CAUSE OF PSEUDOLEUKOPENIA SO ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE LA English DT Article ID AGGREGATION; BLOOD AB Transient cold agglutination of her granulocytes developed in a 60-year-old woman with a left upper lobe pneumonia during the acute phase of her illness. This phenomenon was manifested by pseudogranulocytopenia, multiple clumps of granulocytes on her peripheral blood smear, and abnormal distribution of granulocytes and monocytes on the white blood cell histogram when measured on an automated hematology analyzer (Coulter S-Plus IV, Coulter Electronics Inc, Hialeah, Fla). The cause is postulated to be an IgM autoantibody directed against components of the granulocyte membranes. Spurious leukopenia is encountered infrequently with automated hematology analyzers. Cold-induced granulocyte agglutination should be recognized as a potential cause of pseudogranulocytopenia so that white blood cell counts can be accurately reported and unnecessary evaluation of patients for leukopenia can be avoided. C1 KELLER ARMY HOSP,DEPT PATHOL,W POINT,NY. KELLER ARMY HOSP,DEPT PRIMARY CARE & COMMUNITY MED,W POINT,NY. RP ROBBINS, SH (reprint author), ANNE ARUNDEL MED CTR,DEPT PATHOL,ANNAPOLIS,MD, USA. NR 9 TC 24 Z9 24 U1 0 U2 0 PU COLLEGE AMER PATHOLOGISTS PI NORTHFIELD PA C/O KIMBERLY GACKI, 325 WAUKEGAN RD, NORTHFIELD, IL 60093-2750 SN 0003-9985 J9 ARCH PATHOL LAB MED JI Arch. Pathol. Lab. Med. PD FEB PY 1991 VL 115 IS 2 BP 155 EP 157 PG 3 WC Medical Laboratory Technology; Medicine, Research & Experimental; Pathology SC Medical Laboratory Technology; Research & Experimental Medicine; Pathology GA EX232 UT WOS:A1991EX23200016 PM 1992982 ER PT J AU FORTE, VA DEVINE, JA CYMERMAN, A AF FORTE, VA DEVINE, JA CYMERMAN, A TI A LATEX MASK FOR COLLECTION OF EXPIRED GASES FROM GOATS SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE LA English DT Note ID VENTILATORY RESPONSES; CHRONIC HYPOXIA; HIGH-ALTITUDE; ACCLIMATIZATION; ADAPTATION AB A latex respiratory mask was developed to collect expired gas from goats in studies of ventilatory adaptation to high altitude The snouts of 15 animals were dimensioned by taking girth measurements. The procedure requires a rough positive mold of wood which is repeadly submerged into latex, then slowly rotated upon removal until skim-like layers form a mask. A supporting harness is attached to the mask by use of three flat straps connected by Dot fasteners. A period of several hours per day for up to 2 weeks may be necessary to allow the animal to become accustomed to wearing the mask. RP FORTE, VA (reprint author), USA,ENVIRONM MED RES INST,KANSAS ST,NATICK,MA 01760, USA. NR 9 TC 0 Z9 0 U1 0 U2 0 PU AEROSPACE MEDICAL ASSOC PI ALEXANDRIA PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 SN 0095-6562 J9 AVIAT SPACE ENVIR MD JI Aviat. Space Environ. Med. PD FEB PY 1991 VL 62 IS 2 BP 176 EP 178 PG 3 WC Public, Environmental & Occupational Health; Medicine, General & Internal; Sport Sciences SC Public, Environmental & Occupational Health; General & Internal Medicine; Sport Sciences GA EV191 UT WOS:A1991EV19100015 PM 2001217 ER PT J AU TOTH, JP SNYDER, AP AF TOTH, JP SNYDER, AP TI DETECTION OF 1,3,5-TRIAZINE DERIVATIVES IN CROP SAMPLES BY THERMOLYSIS ATMOSPHERIC-PRESSURE IONIZATION TANDEM MASS-SPECTROMETRY SO BIOLOGICAL MASS SPECTROMETRY LA English DT Article ID CHEMICAL IONIZATION; TRIPLE QUADRUPOLES; BIO-POLYMERS; CYROMAZINE; PYROLYSIS; MELAMINE AB Pulsed pyrolysis (Py) in combination with atmospheric pressure ionization (API) and tandem mass spectrometry was investigated as a method for detecting 1,3,5-triazine pesticide residues in agricultural matrices with minimal sample preparation. Analytes investigated were thermally stable and produced Py-API mass spectra that contained essentially only the protonated molecule. Collision-induced dissociation yielded daughter ions attributable to cleavage of the triazine ring. Limits of detection for analytes in crop samples ranged from 10(-1) to 10(2) mg residue per kilogram of substrate, depending on the nature of both analyte and substrate. C1 USA,CTR CHEM RES DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010. RP TOTH, JP (reprint author), UNIV FLORIDA,DEPT FOOD SCI & HUMAN NUTR,GAINESVILLE,FL 32611, USA. NR 16 TC 6 Z9 6 U1 0 U2 1 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 1052-9306 J9 BIOL MASS SPECTROM JI Biol. Mass Spectrom. PD FEB PY 1991 VL 20 IS 2 BP 70 EP 74 DI 10.1002/bms.1200200205 PG 5 WC Biophysics; Spectroscopy SC Biophysics; Spectroscopy GA FB152 UT WOS:A1991FB15200004 ER PT J AU LAWLOR, BA NEWHOUSE, PA BALKIN, TJ MOLCHAN, SE MELLOW, AM MURPHY, DL SUNDERLAND, T AF LAWLOR, BA NEWHOUSE, PA BALKIN, TJ MOLCHAN, SE MELLOW, AM MURPHY, DL SUNDERLAND, T TI A PRELIMINARY-STUDY OF THE EFFECTS OF NIGHTTIME ADMINISTRATION OF THE SEROTONIN AGONIST, M-CPP, ON SLEEP ARCHITECTURE AND BEHAVIOR IN HEALTHY-VOLUNTEERS SO BIOLOGICAL PSYCHIATRY LA English DT Article ID SLOW-WAVE SLEEP; META-CHLOROPHENYLPIPERAZINE; NEURO-ENDOCRINE; 5-HT2 RECEPTORS; HUMAN-BRAIN; ANTAGONIST; TRAZODONE; SITES; RATS; MCPP AB The effects of m-chlorophenylpiperazine (m-CPP) (0.5 mg/kg) on sleep architecture and behavior were examined in six healthy volunteers following a single oral dose of the drug in a randomized, double-blind, placebo-controlled study. m-CPP reduced total sleep time (TST) and sleep efficiency in all subjects. Slow-wave sleep (SWS) and rapid-eye-movement (REM) sleep were decreased and stage 1 sleep was prolonged in a majority of subjects. Prominent behavioral and psychological effects were reported in five out of six subjects following m-CPP (but not following placebo) that interfered with sleep. The sleep disruption and behavioral activation following nighttime administration of m-CPP contrasts with the sedative properties of its parent compound, trazodone, suggesting that the hypnotic effect of trazodone is not related to the agonist profile of its metabolite, m-CPP. C1 WALTER REED ARMY MED CTR,DEPT BEHAV BIOL,WASHINGTON,DC 20307. NIMH,CLIN SCI LAB,BETHESDA,MD 20892. UNIV MICHIGAN,DEPT PSYCHIAT,ANN ARBOR,MI 48109. UNIV VERMONT,COLL MED,DEPT PSYCHIAT,NEUROSCI RES UNIT,BURLINGTON,VT. RP LAWLOR, BA (reprint author), CUNY MT SINAI SCH MED,DEPT PSYCHIAT,DIV GERIATR PSYCHIAT,1 GUSTAVE L LEVY PL,NEW YORK,NY 10029, USA. RI Newhouse, Paul/J-4597-2014 NR 26 TC 42 Z9 44 U1 1 U2 3 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0006-3223 J9 BIOL PSYCHIAT JI Biol. Psychiatry PD FEB 1 PY 1991 VL 29 IS 3 BP 281 EP 286 DI 10.1016/0006-3223(91)91290-8 PG 6 WC Neurosciences; Psychiatry SC Neurosciences & Neurology; Psychiatry GA EX037 UT WOS:A1991EX03700010 PM 2015332 ER PT J AU PRUITT, BA AF PRUITT, BA TI INFECTION AND THE BURN PATIENT - REPLY SO BRITISH JOURNAL OF SURGERY LA English DT Letter RP PRUITT, BA (reprint author), USA,INST SURG RES,FT SAM HOUSTON,TX 78234, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU BLACKWELL SCIENCE LTD PI OXFORD PA OSNEY MEAD, OXFORD, OXON, ENGLAND OX2 0EL SN 0007-1323 J9 BRIT J SURG JI Br. J. Surg. PD FEB PY 1991 VL 78 IS 2 BP 248 EP 248 PG 1 WC Surgery SC Surgery GA FA059 UT WOS:A1991FA05900041 ER PT J AU DILLON, TM BURTON, WDS AF DILLON, TM BURTON, WDS TI ACUTE TOXICITY OF PCB CONGENERS TO DAPHNIA-MAGNA AND PIMEPHALES-PROMELAS SO BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY LA English DT Article ID POLYCHLORINATED BIPHENYL CONGENERS; CHLORINATED HYDROCARBONS; AQUEOUS SOLUBILITY; WATER; SYSTEMS C1 UNIV TENNESSEE,GRAD PROGRAM ECOL,KNOXVILLE,TN 37996. RP DILLON, TM (reprint author), USA,ENGINEER WATERWAYS EXPT STN,ENVIRONM LAB,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 21 TC 11 Z9 11 U1 1 U2 3 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0007-4861 J9 B ENVIRON CONTAM TOX JI Bull. Environ. Contam. Toxicol. PD FEB PY 1991 VL 46 IS 2 BP 208 EP 215 PG 8 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA ET714 UT WOS:A1991ET71400007 PM 1902128 ER PT J AU GLASS, GE KORCH, GW GOMEZ, JE CHILDS, JE AF GLASS, GE KORCH, GW GOMEZ, JE CHILDS, JE TI USING EXOTIC ANTIGENS TO MEASURE REPRODUCTION AND DISPERSAL IN PEROMYSCUS-LEUCOPUS SO CANADIAN JOURNAL OF ZOOLOGY-REVUE CANADIENNE DE ZOOLOGIE LA English DT Note AB Free-ranging female white-footed mice, Peromyscus leucopus, were inoculated with a series of exotic (not encountered in the environment) antigens to evaluate the utility of maternally transferred antibodies in identifying offspring under field conditions. Inoculated females suffered no apparent effects from the antigens, and their survival, growth, and reproductive success did not differ from those of uninoculated, control females. Six of nine marked females produced seven offspring. These offspring dispersed an average of 64 m from their mothers' centers of activity. Recruitment rates per adult female were similar to those reported for nest box studies. The exotic antigen technique appears to be a feasible method for studying the population biology of secretive small mammals. C1 USA,ENVIRONM HYG AGCY,DIV PEST MANAGEMENT PESTICIDE MONITORING,ABERDEEN PROVING GROUND,MD 21010. RP GLASS, GE (reprint author), JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,DEPT IMMUNOL & INFECT DIS,615 N WOLFE ST,BALTIMORE,MD 21205, USA. RI Childs, James/B-4002-2012 NR 6 TC 0 Z9 0 U1 0 U2 2 PU NATL RESEARCH COUNCIL CANADA PI OTTAWA PA RESEARCH JOURNALS, MONTREAL RD, OTTAWA ON K1A 0R6, CANADA SN 0008-4301 J9 CAN J ZOOL JI Can. J. Zool.-Rev. Can. Zool. PD FEB PY 1991 VL 69 IS 2 BP 528 EP 530 DI 10.1139/z91-079 PG 3 WC Zoology SC Zoology GA FC982 UT WOS:A1991FC98200039 ER PT J AU FITZPATRICK, TM COVELLI, HD TENHOLDER, MF AF FITZPATRICK, TM COVELLI, HD TENHOLDER, MF TI THE ACUTE AND INSIDIOUS ONSET OF PULMONARY METASTATIC TRANSITIONAL CELL-CARCINOMA SO CHEST LA English DT Note ID TUMOR EMBOLI; BLADDER; LUNG AB Transitional cell carcinoma is a common urologic neoplasm. Although pulmonary metastases from this tumor are often not appreciated clinically, they are frequently documented in autopsy studies. Therefore, the clinical recognition of this condition can be problematic. To illustrate this point, we present three patients with progressive unexplained dyspnea and histories of transitional cell carcinoma. Since ineffective and possibly detrimental therapeutic approaches may be initiated, a high index of suspicion for pulmonary metastatic embolization must be maintained. Early histologic identification of these metastatic emboli and initiation of effective chemotherapy may prove beneficial for improved quality of life. C1 PULM CONSULTANTS CENT INDIANA,ANDERSON,IN. UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. VET ADM MED CTR,SERV PULM DIS,AUGUSTA,GA 30904. RP FITZPATRICK, TM (reprint author), WALTER REED ARMY MED CTR,PULM DIS SERV,WD 77,WASHINGTON,DC 20307, USA. NR 13 TC 4 Z9 4 U1 0 U2 0 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 SN 0012-3692 J9 CHEST JI Chest PD FEB PY 1991 VL 99 IS 2 BP 498 EP 500 DI 10.1378/chest.99.2.498 PG 3 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA EW488 UT WOS:A1991EW48800050 PM 1989817 ER PT J AU SHANLEY, DJ LUYCKX, BA HAGGERTY, MF MURPHY, TF AF SHANLEY, DJ LUYCKX, BA HAGGERTY, MF MURPHY, TF TI SPONTANEOUS PNEUMOTHORAX IN AIDS PATIENTS WITH RECURRENT PNEUMOCYSTIS-CARINII PNEUMONIA DESPITE AEROSOLIZED PENTAMIDINE PROPHYLAXIS SO CHEST LA English DT Note AB Aerosolized pentamidine prophylaxis for Pneumocystis carinii pneumonia in patients with the acquired immunodeficiency syndrome (AIDS) may predispose these patients to recurrent apical Pneumocystis infection. Bullous changes and pulmonary cysts develop in the lung apices due to repeated episodes of inflammation and cytotoxic effects of HIV on pulmonary macrophages. These changes progress despite prophylaxis against recurrent Pneumocystis infection with aerosolized pentamidine, increasing the risk of spontaneous pneumothorax. Two cases are presented of bilateral pneumothoraces in patients with AIDS and recurrent P carinii pneumonia despite aerosolized pentamidine prophylaxis. Patients receiving aerosolized pentamidine prophylaxis for Pneumocystis pneumonia appear to have an increased risk of pneumothorax due to recurrent apical infections with P carinii. RP SHANLEY, DJ (reprint author), TRIPLER ARMY MED CTR,DEPT RADIOL,HONOLULU,HI 96859, USA. NR 8 TC 18 Z9 18 U1 0 U2 0 PU AMER COLL CHEST PHYSICIANS PI NORTHBROOK PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 SN 0012-3692 J9 CHEST JI Chest PD FEB PY 1991 VL 99 IS 2 BP 502 EP 504 DI 10.1378/chest.99.2.502 PG 3 WC Critical Care Medicine; Respiratory System SC General & Internal Medicine; Respiratory System GA EW488 UT WOS:A1991EW48800052 PM 1989819 ER PT J AU YANG, ZQ ZHANG, TM ZHANG, MY ZHENG, ZM HU, ZJ QU, CF XIANG, JM HUGGINS, JW COSGRIFF, TM SMITH, JI AF YANG, ZQ ZHANG, TM ZHANG, MY ZHENG, ZM HU, ZJ QU, CF XIANG, JM HUGGINS, JW COSGRIFF, TM SMITH, JI TI INTERRUPTION STUDY OF VIREMIA OF PATIENTS WITH HEMORRHAGIC-FEVER WITH RENAL SYNDROME IN THE FEBRILE PHASE SO CHINESE MEDICAL JOURNAL LA English DT Article ID RIBAVIRIN AB Kinetic changes of viremia were observed in 287 cases of hemorrhagic fever with renal syndrome (HFRS) in whom ribavirin was administered with double blind random control studied by means of virus isolation, indirect immunofluorescence assay and enzyme-linked immunosorbent assay. The positive rate of viremia was 79.7% (Sp = 3%) and positive rate of HERS IgM was 85% (Sp = 3.1%) before treatment. Viremia could be interrupted by ribavirin as in the ribavirin treated group, the viremia positive rate decreased, duration of viremia was shortened, viral antigen products, virus titer and HFRS IgG antibody level were reduced as compared with the control group. This showed that viremia was very frequent in patients in the febrile phase and ribavirin is an effective antiviral drug in HFRS during the febrile phase. Dosage and course of treatment of this drug are discussed. C1 USA,MED RES INST INFECT DIS,FREDERICK,MD 21701. RP YANG, ZQ (reprint author), HUBEI MED COLL,VIRUS RES INST,WUHAN 430071,PEOPLES R CHINA. NR 15 TC 7 Z9 9 U1 1 U2 5 PU CHINESE MEDICAL ASSOCIATION PI BEIJING PA 42 DONGSI XIDAJIE, BEIJING 100710, PEOPLES R CHINA SN 0366-6999 J9 CHINESE MED J-PEKING JI Chin. Med. J. PD FEB PY 1991 VL 104 IS 2 BP 149 EP 153 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA FA919 UT WOS:A1991FA91900012 PM 1678691 ER PT J AU DOOLEY, DP COX, RA LOONEY, DJ AF DOOLEY, DP COX, RA LOONEY, DJ TI EFFECT OF A RECOMBINANT HIV GP160 VACCINE ON MONOKINE PRODUCTION SO CLINICAL AND EXPERIMENTAL IMMUNOLOGY LA English DT Article DE AIDS; MONOKINES; GP160; INTERLEUKIN-1; TUMOR NECROSIS FACTOR-ALPHA ID TUMOR NECROSIS FACTOR; HUMAN IMMUNODEFICIENCY VIRUS; T-CELL CLONE; FACTOR-ALPHA; MONONUCLEAR PHAGOCYTES; GENE-EXPRESSION; BLOOD MONOCYTES; SYNDROME AIDS; TNF-ALPHA; INTERLEUKIN-1 AB An investigation was undertaken to determine whether a recombinant gp 160 envelope protein, which is currently being evaluted as a vaccine for AIDS, induces or modulates the production of tumour necrosis factor-alpha (TNF-alpha) or interleukin-1-beta (IL-1-beta). Incubation of monocytes from healthy, HIV-seronegative persons with 0.0001-1.0-mu-g of the recombinant vaccine did not result in the secretion of TNF-alpha or IL-1-beta, nor did the recombinant product augment or suppress monokine production by lipopolysaccharide (LPS) stimulated monocytes. The vaccine was also without a stimulatory or modulatory effect upon TNF-alpha or IL-1-beta secretion by monocytes from a patient with the AIDS-related complex (ARC) and from the monocytic THP-1 cell line. The lack of effect of gp 160 on monokine production has important implications for its efficacy as a vaccine for AIDS. C1 SAN ANTONIO STATE CHEST HOSP,DEPT RES IMMUNOL,SAN ANTONIO,TX 78223. BROOKE ARMY MED CTR,INFECT DIS SERV,FT SAM HOUSTON,TX 78234. WALTER REED ARMY MED CTR,DIV RETROVIROL,WASHINGTON,DC 20307. NR 40 TC 1 Z9 1 U1 0 U2 0 PU BLACKWELL SCIENCE LTD PI OXFORD PA OSNEY MEAD, OXFORD, OXON, ENGLAND OX2 0EL SN 0009-9104 J9 CLIN EXP IMMUNOL JI Clin. Exp. Immunol. PD FEB PY 1991 VL 83 IS 2 BP 192 EP 196 PG 5 WC Immunology SC Immunology GA EV433 UT WOS:A1991EV43300002 PM 1993354 ER PT J AU WARD, FT ANDERSON, JH JELINEK, J ANDERSON, DW AF WARD, FT ANDERSON, JH JELINEK, J ANDERSON, DW TI LOCALIZATION OF METASTATIC ADRENAL-CORTICAL CARCINOMA ITH GA-67 SO CLINICAL NUCLEAR MEDICINE LA English DT Article ID LUNG; MECHANISMS; TUMORS AB Data are limited on the localization of Ga-67 in primary or metastatic adrenal cortical carcinoma. We report the localization of Ga-67 to pathologically confirmed adrenal cortical carcinoma metastatic to the lung. A review of the literature revealed four patients have previously been reported to have metastatic adrenal cortical carcinoma detected on Ga-67 scan. Gallium imaging may be useful in the evaluation of patients with adrenal cortical carcinoma. SPECT imaging should further improve lesion resolution and localization. C1 WALTER REED ARMY MED CTR,DEPT RADIOL,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,DEPT PATHOL,WASHINGTON,DC 20307. RP WARD, FT (reprint author), WALTER REED ARMY MED CTR,DEPT MED,HEMATOL ONCOL SERV,WASHINGTON,DC 20307, USA. NR 17 TC 4 Z9 4 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0363-9762 J9 CLIN NUCL MED JI Clin. Nucl. Med. PD FEB PY 1991 VL 16 IS 2 BP 117 EP 119 DI 10.1097/00003072-199102000-00011 PG 3 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA EW616 UT WOS:A1991EW61600011 PM 2004492 ER PT J AU SULLIVAN, CA FRANCIS, GL BAIN, MW HARTZ, J AF SULLIVAN, CA FRANCIS, GL BAIN, MW HARTZ, J TI MUNCHAUSEN-SYNDROME BY PROXY - 1990 A PORTENT FOR PROBLEMS SO CLINICAL PEDIATRICS LA English DT Article C1 WALTER REED ARMY MED CTR,DEPT PEDIAT,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT CHILD & ADOLESCENT PSYCHIAT,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT SOCIAL SERV,WASHINGTON,DC 20307. NR 11 TC 10 Z9 10 U1 0 U2 0 PU WESTMINSTER PUBL INC PI GLEN HEAD PA 708 GLEN COVE AVE, GLEN HEAD, NY 11545 SN 0009-9228 J9 CLIN PEDIATR JI Clin. Pediatr. PD FEB PY 1991 VL 30 IS 2 BP 112 EP 116 DI 10.1177/000992289103000213 PG 5 WC Pediatrics SC Pediatrics GA FE797 UT WOS:A1991FE79700012 PM 2007302 ER PT J AU ZEIGLER, D LYNCH, SA MUIR, J BENJAMIN, J MAX, M AF ZEIGLER, D LYNCH, SA MUIR, J BENJAMIN, J MAX, M TI TRANSDERMAL CLONIDINE VS PLACEBO IN PAINFUL DIABETIC NEUROPATHY SO CLINICAL PHARMACOLOGY & THERAPEUTICS LA English DT Meeting Abstract C1 NIDR,BETHESDA,MD 20892. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0009-9236 J9 CLIN PHARMACOL THER JI Clin. Pharmacol. Ther. PD FEB PY 1991 VL 49 IS 2 BP 132 EP 132 PG 1 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA EZ620 UT WOS:A1991EZ62000037 ER PT J AU KINSELLA, JP GERSTMANN, DR DELEMOS, RA AF KINSELLA, JP GERSTMANN, DR DELEMOS, RA TI CEREBRAL BLOOD-FLOW FOLLOWING PREMATURE DELIVERY IN A NONHUMAN PRIMATE MODEL OF HYALINE-MEMBRANE DISEASE SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 USA,FITZSIMONS MED CTR,AURORA,CO. SW FDN BIOMED RES,SAN ANTONIO,TX 78284. NR 0 TC 0 Z9 0 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 SN 0009-9279 J9 CLIN RES JI Clin. Res. PD FEB PY 1991 VL 39 IS 1 BP A72 EP A72 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA ET786 UT WOS:A1991ET78600396 ER PT J AU UYEHARA, CFT PICHOFF, BE NAKAMURA, KT AF UYEHARA, CFT PICHOFF, BE NAKAMURA, KT TI OXYGEN EXPOSURE ENHANCES AIRWAY REACTIVITY IN NEWBORN GUINEA-PIGS SO CLINICAL RESEARCH LA English DT Meeting Abstract C1 KAPIOLANI MED CTR,HONLULU,HI. TRIPLER ARMY MED CTR,HONOLULU,HI. NR 0 TC 1 Z9 1 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 SN 0009-9279 J9 CLIN RES JI Clin. Res. PD FEB PY 1991 VL 39 IS 1 BP A43 EP A43 PG 1 WC Medicine, Research & Experimental SC Research & Experimental Medicine GA ET786 UT WOS:A1991ET78600239 ER PT J AU TYLER, PS LEVY, M RAYMOND, L AF TYLER, PS LEVY, M RAYMOND, L TI INVESTIGATION OF THE CONDITIONS FOR CRACK-PROPAGATION AND ARREST UNDER CATHODIC POLARIZATION BY RISING STEP LOAD BEND TESTING SO CORROSION LA English DT Article DE CRACK ARREST; CRACK PROPAGATION; HYDROGEN EMBRITTLEMENT; KISCC; STRESS CORROSION CRACKING AB The effects of potential step polarization and hydrogen overpotential on crack propagation and crack arrest are investigated for T-250 maraging steel (yield strength = 1708 MPa [248 ksi]) and PH 13-8 (UNS(1) S13800) steel (yield strength = 1467 MPa [213 ksi]). The critical stress intensity threshold for hydrogen-assisted cracking, K(ISCC), measured as a function of potential using a rising step load bend (RSL-B) technique, is compared to K(ISCC) vs potential curves by other investigators. Both materials showed an increase in K(ISCC) with increasing potential. A fractographic examination of specimens tested at different potentials revealed distinct changes in the fracture mechanism as a function of potential that are explained in terms of the decohesion model for hydrogen-assisted cracking. The crack arrest and propagation experiments reveal that the crack tip responds instantly to changes in the hydrogen activity, ie., step polarization. The ability to arrest and restart crack propagation by stepping the applied potential at a constant applied stress intensity is demonstrated, proving that K(ISCC) is a direct function of the hydrogen overpotential at the crack tip. C1 USA,MAT TECH LAB,SLCMT,MCM,SB,WATERTOWN,MA 02172. LRA LABS INC,IRVINE,CA 92714. RP TYLER, PS (reprint author), IBM CORP,HWY 52 & 37TH ST NW,ROCHESTER,MN 55901, USA. NR 22 TC 7 Z9 7 U1 0 U2 1 PU NATL ASSN CORROSION ENG PI HOUSTON PA 1440 SOUTH CREEK DRIVE, HOUSTON, TX 77084-4906 SN 0010-9312 J9 CORROSION JI Corrosion PD FEB PY 1991 VL 47 IS 2 BP 82 EP 87 PG 6 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA FX700 UT WOS:A1991FX70000001 ER PT J AU HEPPNER, DG EDELMAN, R AF HEPPNER, DG EDELMAN, R TI TREATMENT OF GASTROINTESTINAL INFECTIONS SO CURRENT OPINION IN GASTROENTEROLOGY LA English DT Article AB The treatment of gastrointestinal infections during 1989 and 1990 advanced on three fronts: first, recognition of the increased prevalence of drug-resistant enteric pathogens and the consequent need to reevaluate optimal therapy; second, the growing role of the quinolones, particularly ciprofloxacin, in the treatment of enteric fevers; and third, the continuing efforts to find more effective therapy for acquired immunodeficiency syndrome (AIDS) patients with diarrhea. RP HEPPNER, DG (reprint author), WALTER REED ARMY MED CTR,DEPT IMMUNOL,WASHINGTON,DC 20307, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU RAPID SCIENCE PUBLISHERS PI LONDON PA 2-6 BOUNDARY ROW, LONDON, ENGLAND SE1 8NH SN 0267-1379 J9 CURR OPIN GASTROEN JI Curr. Opin. Gastroenterol. PD FEB PY 1991 VL 7 IS 1 BP 116 EP 122 DI 10.1097/00001574-199102000-00020 PG 7 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA FC090 UT WOS:A1991FC09000019 ER PT J AU SURR, RK FABRY, DA AF SURR, RK FABRY, DA TI COMPARISON OF 3 HEARING-AID FITTINGS USING THE SPEECH-INTELLIGIBILITY RATING (SIR) TEST SO EAR AND HEARING LA English DT Article ID NATIONAL-ACOUSTIC-LABORATORIES; LOW-FREQUENCY AMPLIFICATION; SELECTION; PERCEPTION AB This study compared the effects of three different hearing aids on subjective ratings of speech intelligibility. Insertion gain measurements on KEMAR indicated that the hearing aid fittings differed primarily in midfrequency gain. The test passages of the Speech Intelligibility Rating Test (SIR) were recorded onto tape through each hearing aid. The processed passages were presented monaurally to 13 subjects with hearing loss limited to frequencies above 2000 Hz. They rated five passages through each frequency response (FR) in a randomized order. Each subject was retested within 2 or 3 days to assess test-retest reliability. Results indicated that the FR with the most midfrequency amplification did not differ significantly from the aid with the least amount of midfrequency gain. However, the FR with intermediate midfrequency gain received significantly lower ratings than did FR with most gain. Examination of the data from individual subjects indicated that the SIR results did not show differences among the FRs for the majority of subjects. RP SURR, RK (reprint author), WALTER REED ARMY MED CTR,CTR ARMY AUDIOL & SPEECH,WASHINGTON,DC 20307, USA. NR 17 TC 5 Z9 5 U1 2 U2 2 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0196-0202 J9 EAR HEARING JI Ear Hear. PD FEB PY 1991 VL 12 IS 1 BP 32 EP 38 DI 10.1097/00003446-199102000-00004 PG 7 WC Audiology & Speech-Language Pathology; Otorhinolaryngology SC Audiology & Speech-Language Pathology; Otorhinolaryngology GA EY223 UT WOS:A1991EY22300003 PM 2026286 ER PT J AU RAY, R CLARK, OE FORD, KW KNIGHT, KR HARRIS, LW BROOMFIELD, CA AF RAY, R CLARK, OE FORD, KW KNIGHT, KR HARRIS, LW BROOMFIELD, CA TI A NOVEL TERTIARY PYRIDOSTIGMINE DERIVATIVE [3-(N,N-DIMETHYLCARBAMYLOXY)-1-METHYL-DELTA-3-TETRAHYDROPYRIDINE] - ANTICHOLINESTERASE PROPERTIES AND EFFICACY AGAINST SOMAN SO FUNDAMENTAL AND APPLIED TOXICOLOGY LA English DT Article; Proceedings Paper CT SYMP AT THE 29TH ANNUAL MEETING OF THE SOC OF TOXICOLOGY : APPLICATION OF PHARMACOKINETICS IN DEVELOPMENT TOXICITY RISK ASSESSMENT CY FEB 12-16, 1990 CL MIAMI BEACH, FL SP SOC TOXICOL, REPRODUCT & DEV SPECIALTY SECT ID ACETYLCHOLINESTERASE; INHIBITION; SYSTEM RP RAY, R (reprint author), USA,MED RES INST CHEM DEF,BIOCHEM PHARMACOL BRANCH,ABERDEEN PROVING GROUND,MD 21010, USA. NR 14 TC 11 Z9 11 U1 0 U2 0 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0272-0590 J9 FUND APPL TOXICOL JI Fundam. Appl. Toxicol. PD FEB PY 1991 VL 16 IS 2 BP 267 EP 274 DI 10.1016/0272-0590(91)90111-G PG 8 WC Toxicology SC Toxicology GA EX314 UT WOS:A1991EX31400010 PM 2055358 ER PT J AU VALANIS, KC PETERS, JF AF VALANIS, KC PETERS, JF TI AN ENDOCHRONIC PLASTICITY THEORY WITH SHEAR-VOLUMETRIC COUPLING SO INTERNATIONAL JOURNAL FOR NUMERICAL AND ANALYTICAL METHODS IN GEOMECHANICS LA English DT Article AB Thermodynamic and physical principles are applied in conjunction with the concepts of endochronic plasticity to develop a theory of constitutive behaviour of soils with dilatant capability. Three separate constitutive models are derived within the framework of the proposed theory, all capable of accounting for shear-volume coupling of soil within the context of endochronic plasticity. One specific model is singled out as the most appropriate on the basis of its analytical simplicity and the plausibility of its thermodynamic and physical foundations. A simple example is worked out for the purpose of illustration. C1 USA,ENGINEER WATERWAYS EXPT STN,VICKSBURG,MS 39180. RP VALANIS, KC (reprint author), ENDOCHRONICS INC,VANCOUVER,WA 98665, USA. NR 17 TC 16 Z9 18 U1 1 U2 2 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0363-9061 J9 INT J NUMER ANAL MET JI Int. J. Numer. Anal. Methods Geomech. PD FEB PY 1991 VL 15 IS 2 BP 77 EP 102 DI 10.1002/nag.1610150202 PG 26 WC Engineering, Geological; Materials Science, Multidisciplinary; Mechanics SC Engineering; Materials Science; Mechanics GA EZ090 UT WOS:A1991EZ09000001 ER PT J AU COWIE, JG TULER, FR AF COWIE, JG TULER, FR TI COMPARISON OF SHEAR AND TENSILE FRACTURE IN HIGH-STRENGTH ALUMINUM-ALLOYS SO INTERNATIONAL JOURNAL OF FRACTURE LA English DT Article AB A comparison was made between tensile (mode I) and shear (mode II) fracture characteristics in high strength aluminium alloys (7075-T6 and 6061-T651) using a relatively new mode II fracture specimen to evaluate the critical stress intensity factor. The enlarged plastic zone during mode II fracture required that an increased specimen thickness be used for determining K(IIc) under a purely plane strain condition. Plane stress conditions prevailed in the mode II fracture of 7075-T6 with a specimen thickness less than 10 mm, while plane strain controlled mode II fracture at a thickness of 10 mm or greater. Fractographic analysis revealed a distinctive difference in the micromechanisms responsible for crack extension. Small dimples were observed only on the mode II fracture surfaces, resulting from a microvoid nucleation fracture mechanism. The mode I fracture surfaces showed a mixed distribution of dimple sizes resulting from a void growth fracture mechanism. Comparing the critical stress intensity factors, the shear mode of failure exhibited a substantially higher value than the tensile mode, resulting from the effect of the sign and magnitude of the hydrostatic stress state on the microvoid nucleation event. Zero hydrostatic tension in the mode II loading configuration helps delay microvoid nucleation, increasing the apparent toughness. The high hydrostatic tension resulting from a mode I loading configuration enhances microvoid nucleation which promotes crack propagation at relatively lower stress intensity factors. C1 USA,MAT TECHNOL LAB,MET RES BRANCH,WATERTOWN,MA 02172. RP COWIE, JG (reprint author), WORCESTER POLYTECH INST,DEPT MECH ENGN,WORCESTER,MA 01609, USA. NR 17 TC 11 Z9 11 U1 1 U2 2 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 0376-9429 J9 INT J FRACTURE JI Int. J. Fract. PD FEB 1 PY 1991 VL 47 IS 3 BP 229 EP 239 PG 11 WC Materials Science, Multidisciplinary; Mechanics SC Materials Science; Mechanics GA EZ286 UT WOS:A1991EZ28600005 ER PT J AU DRESSENDORFER, RH WADE, CE CLAYBAUGH, J CUCINELL, SA TIMMIS, GC AF DRESSENDORFER, RH WADE, CE CLAYBAUGH, J CUCINELL, SA TIMMIS, GC TI EFFECTS OF 7 SUCCESSIVE DAYS OF UNACCUSTOMED PROLONGED EXERCISE ON AEROBIC PERFORMANCE AND TISSUE-DAMAGE IN FITNESS JOGGERS SO INTERNATIONAL JOURNAL OF SPORTS MEDICINE LA English DT Article DE JOGGING; TISSUE DAMAGE; MYOGLOBIN; CREATINE KINASE; HEMOGLOBIN; VO2MAX ID ACUTE EXERTIONAL RHABDOMYOLYSIS; MARATHON RUNNERS; RENAL-FUNCTION; MUSCLE DAMAGE; RESPONSES; MYOGLOBINEMIA; HYPERVOLEMIA; INDICATORS; POWER; RACE AB The effects of 7 successive days of prolonged jogging on aerobic performance and biochemical markers of muscle and red blood cell damage were examined in 10 moderately fit men, ages 27 +/- 2 yr (mean +/- SE). The subjects jogged for 2 h per day at 78 +/- 4% of maximal heart rates and covered a total of 129 +/- 2 km, nearly eight times their regular weekly training distance. At baseline, maximal oxygen uptake (VO2max) during treadmill tests averaged 3.45 +/- 0.24 L/min, or 44.7 +/- 1.4 ml/kg/min. On follow-up tests 2d after the week of increased training, VO2max (3.56 +/- 0.17 L/min) and treadmill performance were not significantly improved. Body weight declined from 79.5 +/- 4.6 kg to 77.8 +/- 4.4 kg (p < 0.05) because of reduced body fatness (16.8 +/- 2.3% to 13.6 +/- 1.7%, p < 0.05). Weight-adjusted VO2max increased to 46.4 +/- 2.0 ml/kg/min (p < 0.05). However, heart rate and systolic blood pressure were not significantly changed at rest, or during submaximal and maximal treadmill exercise. Mean hemoglobin concentration at treadmill testing declined from 14.9 +/- 0.3 g/dl to 13.3 +/- 0.3 g/dl (p < 0.05). Leg muscle soreness, especially in the thigh region, persisted in all subjects after 3 d. Soreness was accompanied by chronic elevations (p < 0.05) in serum levels of myoglobin, creatine kinase (CK), lactic dehydrogenase (LD), aminoaspartate, and the isoenzymes CK-MB and LD1,2. Serum haptoglobin levels after jogging fell from 86 +/- 9 mg/dl to 60 +/- 8 mg/dl (p < 0.05), suggestive of foot-strike hemolysis. It was concluded that leg muscle fibers and red blood cells were damaged by the unaccustomed high training distance. The reduction in hemoglobin concentration may have attenuated potential training effects on aerobic performance by decreasing the oxygen carrying capacity of the blood. The intensified training did not promote a short-term gain in cardiovascular fitness. C1 TRIPLER ARMY MED CTR,DEPT CLIN INVEST,HONOLULU,HI 96859. WILLIAM BEAUMONT HOSP,DIV CARDIOVASC DIS,ROYAL OAK,MI 48072. LETTERMAN ARMY INST RES,DIV MIL TRAUMA RES,SAN FRANCISCO,CA 94129. NR 38 TC 21 Z9 22 U1 0 U2 3 PU GEORG THIEME VERLAG PI STUTTGART PA P O BOX 30 11 20, D-70451 STUTTGART, GERMANY SN 0172-4622 J9 INT J SPORTS MED JI Int. J. Sports Med. PD FEB PY 1991 VL 12 IS 1 BP 55 EP 61 DI 10.1055/s-2007-1024656 PG 7 WC Sport Sciences SC Sport Sciences GA EZ570 UT WOS:A1991EZ57000012 PM 2030061 ER PT J AU VONHOFF, DD GREEN, SJ NEIDHART, JA FABIAN, C BUDD, T BOYD, JF OSBORNE, CK AF VONHOFF, DD GREEN, SJ NEIDHART, JA FABIAN, C BUDD, T BOYD, JF OSBORNE, CK TI PHASE-II STUDY OF L-ALANOSINE (NSC-153353) IN PATIENTS WITH ADVANCED BREAST-CANCER - A SOUTHWEST ONCOLOGY GROUP-STUDY SO INVESTIGATIONAL NEW DRUGS LA English DT Note DE PHASE-II; L-ALANOSINE; BREAST CANCER C1 UNIV TEXAS,HLTH SCI CTR,SAN ANTONIO,TX 78284. SW ONCOL GRP,CTR BIOSTAT,SEATTLE,WA. UNIV NEW MEXICO,ALBUQUERQUE,NM 87131. UNIV KANSAS,MED CTR,KANSAS CITY,KS 66103. CLEVELAND CLIN EDUC FDN,CLEVELAND,OH 44106. BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234. FU NCI NIH HHS [CA-22433, CA-04919, CA-22411] NR 5 TC 5 Z9 5 U1 0 U2 1 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 0167-6997 J9 INVEST NEW DRUG JI Invest. New Drugs PD FEB PY 1991 VL 9 IS 1 BP 87 EP 88 PG 2 WC Oncology; Pharmacology & Pharmacy SC Oncology; Pharmacology & Pharmacy GA EZ122 UT WOS:A1991EZ12200016 PM 2026487 ER PT J AU BLAT, CE NICOLLIAN, EH POINDEXTER, EH AF BLAT, CE NICOLLIAN, EH POINDEXTER, EH TI MECHANISM OF NEGATIVE-BIAS-TEMPERATURE INSTABILITY SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID HIGH ELECTRIC-FIELDS; SI-SIO2 INTERFACE; PB CENTERS; STRESS AB Although negative-bias-temperature instability in metal-oxide-semiconductor integrated circuits has been minimized empirically, the exact mechanism is unknown. We argue in this paper that the mechanism of negative-bias-temperature instability can be modeled by a first-order electrochemical reaction between hydrogenated trivalent silicon, a neutral water-related species located in the oxide near the Si-SiO2 interface, and holes at the silicon surface to form neutral trivalent silicon and a positively charged water-related species. To show that such a reaction describes the phenomenon, we show that (1) water must be present in the oxide near the Si-SiO2 interface, (2) induced interface and oxide-fixed charge densities are equal, (3) the saturation interface-trap and oxide-fixed charge densities depend on the initial hole concentration at the silicon surface or aging field, (4) the buildup of these charge densities follows first-order reaction kinetics, and (5) time constants for this charge buildup are independent of aging field. The measurements which are done to demonstrate these features combine room-temperature charge measurement using the Q-C method with current measurements during accelerated aging. C1 MICROELECTR CTR N CAROLINA,RES TRIANGLE PK,NC 27709. USA,FT MONMOUTH,NJ 07703. RP BLAT, CE (reprint author), UNIV N CAROLINA,CHARLOTTE,NC 28223, USA. NR 15 TC 190 Z9 197 U1 2 U2 10 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD FEB 1 PY 1991 VL 69 IS 3 BP 1712 EP 1720 DI 10.1063/1.347217 PG 9 WC Physics, Applied SC Physics GA EW671 UT WOS:A1991EW67100089 ER PT J AU FREUND, BJ SHIZURU, EM HASHIRO, GM CLAYBAUGH, JR AF FREUND, BJ SHIZURU, EM HASHIRO, GM CLAYBAUGH, JR TI HORMONAL, ELECTROLYTE, AND RENAL RESPONSES TO EXERCISE ARE INTENSITY DEPENDENT SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE ATRIAL NATRIURETIC PEPTIDE; VASOPRESSIN; ALDOSTERONE; PLASMA RENIN ACTIVITY; URINARY RESPONSES; EXERCISE INTENSITY ID ATRIAL NATRIURETIC FACTOR; RENIN-ACTIVITY; PLASMA-RENIN; VASOPRESSIN; ALDOSTERONE; RELEASE; HEMORRHAGE; PEPTIDE; VOLUME; MEN AB Previous work indicates that the magnitude and direction of renal responses to exercise depend on the exercise intensity. To examine mechanisms responsible for these findings, renal and hormonal responses were studied in eight healthy male subjects (29.6 +/- 1.9 yr) before and immediately after four 20-min bouts of submaximal exercise (cycle ergometry) at work loads representing 25, 40, 60, and 80% of maximal oxygen consumption. Urine flow, osmotic clearance, glomerular filtration rate, and sodium excretion (U(Na)+V) all tended to rise at the 25% work load but were markedly reduced at the higher work intensities. Changes in urine flow paralleled changes in glomerular filtration rate (r = 0.91). Plasma vasopressin (ADH), aldosterone, and plasma renin activity tended to increase progressively with increases in work load, with the increases for all hormones reaching statistical significance when the level of exercise reached greater-than-or-equal-to 60% of maximal oxygen consumption. However, atrial natriuretic peptide was elevated (P < 0.05) at all work loads from > 1.6-fold of control levels at the 25% work load to > 7-fold at the 80% work load. The increase in urine flow (6 of 8 subjects) and U(Na)+V (7 of 8 subjects) may be due to the increase in atrial natriuretic peptide and/or a 10% suppression (P < 0.05) of ADH at the 25% work load. Despite ADH being elevated (P < 0.05) 1.8- and 4.5-fold at the 60 and 80% work loads, average free water clearance increased (P < 0.05) by 0.5 and 1.2 ml/min and urinary osmolality decreased (P < 0.05) by 29.7 and 24.3 mosmol/kg, respectively, indicating that during high-intensity exercise the concentrating capability of the kidney may be impaired. RP FREUND, BJ (reprint author), TRIPLER ARMY MED CTR,DEPT CLIN INVEST,HSHK-CI FREUND BLDG,40 1ST FLOOR,HONOLULU,HI 96859, USA. NR 29 TC 85 Z9 88 U1 0 U2 4 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 8750-7587 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD FEB PY 1991 VL 70 IS 2 BP 900 EP 906 PG 7 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA EX526 UT WOS:A1991EX52600056 PM 1827109 ER PT J AU HERMANSKY, SJ STOHS, SJ ELDEEN, ZM ROCHE, VF MEREISH, KA AF HERMANSKY, SJ STOHS, SJ ELDEEN, ZM ROCHE, VF MEREISH, KA TI EVALUATION OF POTENTIAL CHEMOPROTECTANTS AGAINST MICROCYSTIN-LR HEPATOTOXICITY IN MICE SO JOURNAL OF APPLIED TOXICOLOGY LA English DT Article DE MICROCYSTIN-LR; HEPATOTOXICITY; CHEMOPROTECTION; CYCLOSPORINE-A; RIFAMPIN; SILYMARIN ID ISOLATED RAT HEPATOCYTES; LIPID-PEROXIDATION; CYCLOSPORIN-A; TOXIC PEPTIDE; MOUSE-LIVER; VITAMIN-E; AERUGINOSA; INHIBITION; CELLS; GLUTATHIONE AB Microcystin-LR (MCLR) is a potent cyclic heptapeptide hepatotoxin produced by the blue-green algae, Microcystis aeruginosa. Toxic blooms of this cyanobacteria have been reported throughout the temperate world. In spite of the potential economic loss and health hazard posed by this toxin, few studies on the development of an antidote have been conducted. Thus, a number of biologically active compounds were tested in mice for effectiveness in preventing the toxicity of a lethal dose of MCLR (100-mu-g kg-1). Efficacy was evaluated based upon the percentage of surviving mice, time to death and serum lactate dehydrogenase activity 45 min after treatment with the toxin. The biologically active compounds were separated into groups based upon proposed mechanisms of action. Enzyme induction by phenobarbital but not by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) resulted in partial protection against toxicity. Calcium channel blockers, free-radical scavengers and water-soluble antioxidants produced little protection against toxicity. The membrane-active antioxidants vitamin E and silymarin, as well as glutathione and the monoethyl ester of glutathione, produced significant protection from lethality. Rifampin and cyclosporin-A, both immunosuppressive and membrane-active agents, which also block the bile acid uptake system of hepatocytes, produced complete protection from the toxicity of MCLR. Thus, lipophilic antioxidants provide partial protection against MCLR toxicity while cyclosporin-A nd rifampin are highly effective and potentially useful antidotes. The toxicity of MCLR may depend upon stimulation of the immune system and may be mediated by membrane alterations. C1 CREIGHTON UNIV,SCH PHARM & ALLIED HLTH PROFESS,OMAHA,NE 68178. USA,MED RES INST INFECT DIS,FREDERICK,MD 21701. NR 54 TC 74 Z9 77 U1 1 U2 7 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0260-437X J9 J APPL TOXICOL JI J. Appl. Toxicol. PD FEB PY 1991 VL 11 IS 1 BP 65 EP 74 DI 10.1002/jat.2550110112 PG 10 WC Toxicology SC Toxicology GA EW024 UT WOS:A1991EW02400011 PM 1902496 ER PT J AU STRETCH, RH AF STRETCH, RH TI PSYCHOSOCIAL READJUSTMENT OF CANADIAN VIETNAM VETERANS SO JOURNAL OF CONSULTING AND CLINICAL PSYCHOLOGY LA English DT Note ID TRAUMATIC STRESS DISORDER; COMBAT C1 USA,MED RES & DEV COMMAND,FT DETRICK,MD. NR 7 TC 7 Z9 7 U1 0 U2 0 PU AMER PSYCHOLOGICAL ASSOC PI WASHINGTON PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 SN 0022-006X J9 J CONSULT CLIN PSYCH JI J. Consult. Clin. Psychol. PD FEB PY 1991 VL 59 IS 1 BP 188 EP 189 DI 10.1037/0022-006X.59.1.188 PG 2 WC Psychology, Clinical SC Psychology GA EV987 UT WOS:A1991EV98700025 PM 2002137 ER PT J AU SMITH, KJ NEAFIE, RC SKELTON, HG BARRETT, TL GRAHAM, JH LUPTON, GP AF SMITH, KJ NEAFIE, RC SKELTON, HG BARRETT, TL GRAHAM, JH LUPTON, GP TI MAJOCCHIS GRANULOMA SO JOURNAL OF CUTANEOUS PATHOLOGY LA English DT Article ID MICROSPORUM-AUDOUINII; INFECTION; DERMATOPHYTOSIS; HOST AB Majocchi's granuloma (nodular granulomatous perifolliculitis) is a well recognized but uncommon infection of dermal and subcutaneous tissue by fungal organisms (dermatophytes) usually limited to the superficial epidermis. The organism usually associated with Majocchi's granuloma is Trichophyton rubrum; however, other dermatophytes including T. mentagrophytes (variety granulosum), T. epilans, T. violaceum, M. audouinii, M. gypseum, M. ferrugineum, and M. canis may be the causative agent. A review of 17 cases revealed not only the variety of possible organisms but also a marked variation from the usual hyphal forms. The morphologic variations including yeast forms, bizarre hyphae, mucinous coatings, and the Splendore-Hoeppeli phenomenon may be factors which allow the dermatophytes to persist and grow in an abnormal location. Also, there is evidence that Majocchi's granuloma may occur in two distinct groups of patients. C1 ARMED FORCES INST PATHOL,DEPT DERMATOPATHOL,WASHINGTON,DC 20306. ARMED FORCES INST PATHOL,DEPT INFECT & PARASIT DIS,WASHINGTON,DC 20306. SCRIPPS CLIN & RES FDN,DEPT PATHOL,LA JOLLA,CA 92037. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 19 TC 39 Z9 41 U1 0 U2 1 PU MUNKSGAARD INT PUBL LTD PI COPENHAGEN PA 35 NORRE SOGADE, PO BOX 2148, DK-1016 COPENHAGEN, DENMARK SN 0303-6987 J9 J CUTAN PATHOL JI J. Cutan. Pathol. PD FEB PY 1991 VL 18 IS 1 BP 28 EP 35 DI 10.1111/j.1600-0560.1991.tb00598.x PG 8 WC Dermatology; Pathology SC Dermatology; Pathology GA EZ143 UT WOS:A1991EZ14300006 PM 2022763 ER PT J AU SALASCHE, SJ GRABSKI, WJ AF SALASCHE, SJ GRABSKI, WJ TI COMPLICATIONS OF FLAPS SO JOURNAL OF DERMATOLOGIC SURGERY AND ONCOLOGY LA English DT Article ID PROPHYLACTIC ANTIBIOTICS; NECROSIS; HEMATOMA; SURGERY AB Flaps are susceptible to the same complications as side-to-side closures. However, as the blood supply to a flap is more precarious, the complication may have a more dire effect. This article catalogues the various acute complications with an emphasis on early recognition and management. C1 HARVARD UNIV,SCH MED,BOSTON,MA 02115. BROOKE ARMY MED CTR,DERMATOL SURG UNIT,FT SAM HOUSTON,TX 78234. NR 25 TC 9 Z9 9 U1 0 U2 0 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0148-0812 J9 J DERMATOL SURG ONC PD FEB PY 1991 VL 17 IS 2 BP 132 EP 140 PG 9 WC Oncology; Dermatology; Surgery SC Oncology; Dermatology; Surgery GA FB650 UT WOS:A1991FB65000003 PM 2002158 ER PT J AU LOUSHINE, RJ WELLER, RN BELLIZZI, R KULILD, JC AF LOUSHINE, RJ WELLER, RN BELLIZZI, R KULILD, JC TI A 2-DAY DECOMPRESSION - A CASE-REPORT OF A MAXILLARY 1ST MOLAR SO JOURNAL OF ENDODONTICS LA English DT Article ID LESIONS AB A case report of a maxillary first molar is presented in which a drainage tube from a decompression procedure was removed 2 days following placement. The oral surgeon who removed the tube scheduled the patient for surgical enucleation of the large periapical lesion. The surgical appointment was subsequently cancelled and routine endodontic follow-up showed continued osseous repair at 3, 6, and 12 months. The decompression of a large periapical lesion is a conservative alternative to surgical enucleation. C1 USA,DENT ACTIV,ENDODONT RESIDENCY PROGRAM,FT GORDON,GA 30905. RP LOUSHINE, RJ (reprint author), USA,DENT ACTIV,FT BENNING,GA, USA. NR 10 TC 5 Z9 5 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0099-2399 J9 J ENDODONT JI J. Endod. PD FEB PY 1991 VL 17 IS 2 BP 85 EP 87 DI 10.1016/S0099-2399(06)81614-6 PG 3 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA EV488 UT WOS:A1991EV48800008 PM 1919408 ER PT J AU WARD, JR HOVANEC, JW ALBIZO, JM SZAFRANIEC, LL BEAUDRY, WT AF WARD, JR HOVANEC, JW ALBIZO, JM SZAFRANIEC, LL BEAUDRY, WT TI DECOMPOSITION OF PHOSPHONOFLUORIDATES ON GLASS SO JOURNAL OF FLUORINE CHEMISTRY LA English DT Article ID HYDROLYSIS AB Neat droplets of O,O-diisopropylphosphorofluoridate (DFP) and O-1,2,2-trimethylpropyl methylphosphonofluoridate (Soman) decompose on glass. In thirty hours at room temperature over 40% of the Soman has been decomposed while nearly 15% of the DFP has been degraded. NMR spectroscopic analysis of the Soman showed that Soman decomposed exclusively by scission of the P-F bond to form O-1,2,2-trimethylpropyl methylphosphonic acid. The rate of decomposition of the two organophosphorus fluorine substrates is proportional to the rate of hydrolysis. The results are consistent with earlier studies which showed that silica or magnesia promoted the decomposition of sarin (O-2-propylisopropyl methylphosphonofluoridate). The rate of decomposition on glass is accelerated in the presence of high humidity. RP WARD, JR (reprint author), USA,CTR CHEM RES DEV & ENGN,RES DIRECTORATE,ABERDEEN PROVING GROUND,MD 21010, USA. NR 6 TC 7 Z9 7 U1 1 U2 7 PU ELSEVIER SCIENCE SA LAUSANNE PI LAUSANNE 1 PA PO BOX 564, 1001 LAUSANNE 1, SWITZERLAND SN 0022-1139 J9 J FLUORINE CHEM JI J. Fluor. Chem. PD FEB PY 1991 VL 51 IS 2 BP 277 EP 282 DI 10.1016/S0022-1139(00)80297-3 PG 6 WC Chemistry, Inorganic & Nuclear; Chemistry, Organic SC Chemistry GA FA927 UT WOS:A1991FA92700012 ER PT J AU FISHER, RS VANDRIESSCHE, W AF FISHER, RS VANDRIESSCHE, W TI K+ SECRETION ACROSS FROG-SKIN - INDUCTION BY REMOVAL OF BASOLATERAL CL- SO JOURNAL OF GENERAL PHYSIOLOGY LA English DT Article ID CORTICAL COLLECTING DUCT; APICAL MEMBRANE; POTASSIUM-TRANSPORT; ISOLATED EPITHELIA; INTRACELLULAR PH; SODIUM-TRANSPORT; RANA-TEMPORARIA; SEROSAL CL; CHANNELS; VOLUME AB We examined the development of K+ secretion after removing Cl- from the basolateral surface of isolated skins of Rana temporaria using noise analysis. K+ secretion was defined by the appearance of a Lorentzian component in the power density spectrum (PDS) when Ba2+ was present in the apical bath (0.5 mM). No Lorentzians were observed when tissues were bathed in control, NaCl Ringer solution. Replacement of basolateral Cl- by gluconate, nitrate, or SO4= (0-Cl(b)) yielded Lorentzians with corner frequencies near 25 Hz, and plateau values (S(o)) that were used to estimate the magnitude of K+ secretion through channels in the apical cell membranes of the principal cells. The response was reversible and reproducible. In contrast, removing apical Cl- did not alter the PDS. Reduction of basolateral Cl- to 11.5 mM induced Lorentzians, but with lower values of S(o). Inhibition of Na+ transport with amiloride or by omitting apical Na+ depressed K+ secretion but did not prevent its appearance in response to 0-Cl(b). Using microelectrodes, we observed depolarization of the intracellular voltage concomitant with increased resistance of the basolateral membrane after 0-Cl(b). Basolateral application of Ba2+ to depolarize cells also induced K+ secretion. Because apical conductance and channel density are unchanged after 0-Cl(b), we conclude that K+ secretion is "induced" simply by an increase of the electrical driving force for K+ exit across this membrane. Repolarization of the apical membrane after 0-Cl(b) eliminated K+ secretion, while further depolarization increased the magnitude of the secretory current. The cell depolarization after 0-Cl(b) is most likely caused directly by a decrease of the basolateral membrane K+ conductance. Ba2+-induced Lorentzians also were elicited by basolateral hypertonic solutions but with lower values of S(o), indicating that cell shrinkage per se could not entirely account for the response to 0-Cl(b) and that the effects of 0-Cl(b) may be partly related to a fall of intracellular Cl-. C1 CATHOLIC UNIV LEUVEN,FYSIOL LAB,B-3000 LOUVAIN,BELGIUM. RP FISHER, RS (reprint author), WALTER REED ARMY MED CTR,DEPT NEPHROL,WASHINGTON,DC 20307, USA. NR 40 TC 9 Z9 9 U1 3 U2 3 PU ROCKEFELLER UNIV PRESS PI NEW YORK PA 222 E 70TH STREET, NEW YORK, NY 10021 SN 0022-1295 J9 J GEN PHYSIOL JI J. Gen. Physiol. PD FEB PY 1991 VL 97 IS 2 BP 219 EP 243 DI 10.1085/jgp.97.2.219 PG 25 WC Physiology SC Physiology GA EW553 UT WOS:A1991EW55300003 PM 2016579 ER PT J AU PRZYBELSKI, RJ MALCOLM, DS BURRIS, DG WINSLOW, RM AF PRZYBELSKI, RJ MALCOLM, DS BURRIS, DG WINSLOW, RM TI CROSS-LINKED HEMOGLOBIN SOLUTION AS A RESUSCITATIVE FLUID AFTER HEMORRHAGE IN THE RAT SO JOURNAL OF LABORATORY AND CLINICAL MEDICINE LA English DT Article ID STROMA-FREE HEMOGLOBIN; POLYMERIZED PYRIDOXYLATED HEMOGLOBIN; BLOOD SUBSTITUTE; O-2 CARRIER; HEMODILUTION; EFFICACY; SHOCK AB Intramolecularly (alpha-alpha) cross-linked hemoglobin has been reported to have oxygen transport properties similar to those of whole blood. The present study evaluated the efficacy of diaspirin alpha-alpha cross-linked hemoglobin solution as a resuscitation fluid, with heart rate, mean arterial pressure, and transcutaneous oxygen tension as the study parameters. Rats were bled and approximately one third of their total blood volume (20 ml/kg) was removed while they were anesthetized; they were then resuscitated with 14% hemoglobin solution. Animals that received either 10 ml/kg (n = 10) or 20 ml/kg (n = 10) of hemoglobin solution responded quickly and positively to the infusions: mean arterial pressures (which had dropped to less 40% of prehemorrhage levels) returned to baseline within 2 minutes of initiating infusion; by 4 minutes, the mean arterial pressures of the hemoglobin-infused groups were significantly higher (p less-than-or-equal-to 0.05) than those in both the autologous shed blood (n = 8) and lactated Ringer's (n = 10) groups. The heart rate and transcutaneous oxygen tension responses in both the half-volume and full-volume replacement hemoglobin groups matched the response to autologous shed blood throughout the hour observation. The favorable hemodynamic response to infusion of cross-linked hemoglobin solution after hemorrhage suggest that this material is comparable to autologous shed blood and superior to lactated Ringer's solution as a resuscitative fluid as assessed in this model. C1 UNIFORMED SERV UNIV HLTH SCI,DEPT SURG,4301 JONES BRIDGE RD,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,MED RES FELLOWSHIP PROGRAM,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT SURG,WASHINGTON,DC 20307. LETTERMAN ARMY INST RES,DIV BLOOD RES,SAN FRANCISCO,CA 94129. NR 53 TC 95 Z9 95 U1 1 U2 3 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0022-2143 J9 J LAB CLIN MED JI J. Lab. Clin. Med. PD FEB PY 1991 VL 117 IS 2 BP 143 EP 151 PG 9 WC Medical Laboratory Technology; Medicine, General & Internal; Medicine, Research & Experimental SC Medical Laboratory Technology; General & Internal Medicine; Research & Experimental Medicine GA EX656 UT WOS:A1991EX65600010 PM 1993856 ER PT J AU JENSEN, PS XENAKIS, SN WOLF, P BAIN, MW AF JENSEN, PS XENAKIS, SN WOLF, P BAIN, MW TI THE MILITARY FAMILY SYNDROME REVISITED - BY THE NUMBERS SO JOURNAL OF NERVOUS AND MENTAL DISEASE LA English DT Article ID PSYCHOPATHOLOGY RATING-SCALES; CHILD-BEHAVIOR PROFILE; INTERRATER AGREEMENT; AGED 6-11; PREVALENCE AB Because concerns have been raised about high levels of psychopathology in military children, the authors used standardized psychopathology rating scales to survey 213 six-to twelve-year-old children of military parents and their parents. Results from children's symptom self-reports, as well as from teachers' ratings of children, indicated that children's symptom levels were at levels consistent with national norms. In contrast, parents' (especially mothers') ratings of children were significantly higher than national norms, as were parents' ratings of their own symptoms. Also, parents' own symptom reports showed somewhat stronger relationships with life stressors presumably affecting the child than did the children's and teachers' reports. Results suggest that parents' reports of children's symptoms may be mediated by the effects of military life stressors on the parents, but these stressors do not necessarily result in higher symptoms in the children. Overall results do not support the notion that levels of psychopathology are greatly increased in children of military parents. Further studies of military families should address the effects of rank and socioeconomic status, housing, and the current impact of life stressors on the parents as well as the children in order to avoid drawing erroneous conclusions about parts or all of the military community. C1 EISENHOWER ARMY MED CTR,DEPT PSYCHIAT & NEUROL,FT GORDON,GA. USA,MED DEPT ACTIV,CAMP ZAMA,JAPAN. USA,MED DEPT ACTIV,FT CAMPELL,KY. RP JENSEN, PS (reprint author), WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT MIL PSYCHIAT,WASHINGTON,DC 20307, USA. NR 27 TC 32 Z9 32 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-3018 J9 J NERV MENT DIS JI J. Nerv. Ment. Dis. PD FEB PY 1991 VL 179 IS 2 BP 102 EP 107 PG 6 WC Clinical Neurology; Psychiatry SC Neurosciences & Neurology; Psychiatry GA EX951 UT WOS:A1991EX95100007 PM 1990071 ER PT J AU MELENDEZ, V PEGGINS, JO BREWER, TG THEOHARIDES, AD AF MELENDEZ, V PEGGINS, JO BREWER, TG THEOHARIDES, AD TI DETERMINATION OF THE ANTIMALARIAL ARTEETHER AND ITS DEETHYLATED METABOLITE DIHYDROARTEMISININ IN PLASMA BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH REDUCTIVE ELECTROCHEMICAL DETECTION SO JOURNAL OF PHARMACEUTICAL SCIENCES LA English DT Article ID DECOMPOSITION PRODUCTS; QINGHAOSU; BLOOD; DIHYDROQINGHAOSU; ARTEMISININ; ELECTRODES; ACID AB A rapid, sensitive, and specific reversed-phase HPLC method using reductive electrochemical detection has been developed for the determination of arteether and its omicron-dealkylated metabolite dihydroartemisinin (DQHS) in plasma. The internal standard assay was validated between 25 and 1000 ng/mL, with a coefficient of variation of < 10% for both intra- and interday accuracy and precision. An assay for determination of arteether only, using the n-propyl ether of DQHS as internal standard, was also developed and validated from 5-500 ng/mL. A new automated sample deoxygenation and injection system is used to greatly increase sample throughput. These methods have been used to study the pharmacokinetics of arteether after intravenous and intramuscular administration. C1 WALTER REED ARMY MED CTR,DEPT PHARMACOL,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307. NR 22 TC 87 Z9 88 U1 0 U2 3 PU AMER PHARMACEUTICAL ASSN PI WASHINGTON PA 2215 CONSTITUTION AVE NW, WASHINGTON, DC 20037 SN 0022-3549 J9 J PHARM SCI JI J. Pharm. Sci. PD FEB PY 1991 VL 80 IS 2 BP 132 EP 138 DI 10.1002/jps.2600800209 PG 7 WC Chemistry, Medicinal; Chemistry, Multidisciplinary; Pharmacology & Pharmacy SC Pharmacology & Pharmacy; Chemistry GA EW661 UT WOS:A1991EW66100008 PM 2051315 ER PT J AU BUTEL, EM CAMPBELL, JC DIFIORE, PM AF BUTEL, EM CAMPBELL, JC DIFIORE, PM TI CROWN MARGIN DESIGN - A DENTAL SCHOOL SURVEY SO JOURNAL OF PROSTHETIC DENTISTRY LA English DT Article ID TO-METAL RESTORATIONS; TOOTH PREPARATION; CERAMIC CROWNS; PORCELAIN; DISTORTION; FIT; CONFIGURATIONS AB A survey of dental schools in the United States and Puerto Rico was conducted concerning ceramometal crown margin design. The crown margin designs taught most often were the flat shoulder, the 45-degree bevel shoulder, and the chamfer. C1 USA,ADV EDUC PROGRAM GEN DENT,FT BRAGG,NC. USA,FIXED PROSTHET & MENTOR ADV EDUC PROGRAM GEN DENT,FT BRAGG,NC. USA,ENDODONT & MENTOR ADV EDUC PROGRAM GEN DENT,FT BRAGG,NC. NR 16 TC 5 Z9 5 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0022-3913 J9 J PROSTHET DENT JI J. Prosthet. Dent. PD FEB PY 1991 VL 65 IS 2 BP 303 EP 305 DI 10.1016/0022-3913(91)90179-Z PG 3 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA EV971 UT WOS:A1991EV97100023 PM 2051369 ER PT J AU NELSON, MW KOTWAL, KR SEVEDGE, SR AF NELSON, MW KOTWAL, KR SEVEDGE, SR TI CHANGES IN VERTICAL DIMENSION OF OCCLUSION IN CONVENTIONAL AND MICROWAVE PROCESSING OF COMPLETE DENTURES SO JOURNAL OF PROSTHETIC DENTISTRY LA English DT Article AB An investigation was made to compare the increase in vertical dimension of occlusion in complete dentures after processing with conventional and microwave procedures. Lucitone-characterized denture base material was used for 15 sets of complete dentures cured conventionally. Justi-characterized acrylic resin and microliquid were used for 15 sets of complete dentures cured by the microwave procedure. The results of the study showed increases in vertical dimension of occlusion in both methods under 1 mm, which is considered technically acceptable. However, a statistically significant larger increase was present in the microwave technique. C1 USA,DENT ACT,WALTER REED ARMY MED CTR,REMOVABLE PROSTHODONT SERV,WASHINGTON,DC 20310. USA,GRAD PROSTHODONT,WASHINGTON,DC 20310. NR 19 TC 11 Z9 12 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0022-3913 J9 J PROSTHET DENT JI J. Prosthet. Dent. PD FEB PY 1991 VL 65 IS 2 BP 306 EP 308 DI 10.1016/0022-3913(91)90180-5 PG 3 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA EV971 UT WOS:A1991EV97100024 PM 2051370 ER PT J AU ROBERTSON, WG AF ROBERTSON, WG TI FIGHTING FOR THE CONFEDERACY - THE PERSONAL RECOLLECTIONS OF ALEXANDER,EDWARD,PORTER - GALLAGHER,GW SO JOURNAL OF SOUTHERN HISTORY LA English DT Book Review RP ROBERTSON, WG (reprint author), USA COMMAND & GEN STAFF COLL,FT LEAVENWORTH,KS 66027, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU SOUTHERN HISTORICAL ASSN PI ATHENS PA UNIV GEORGIA HISTORY DEPT, ATHENS, GA 30602 SN 0022-4642 J9 J SOUTHERN HIST JI J. South. Hist. PD FEB PY 1991 VL 57 IS 1 BP 118 EP 119 DI 10.2307/2209900 PG 2 WC History SC History GA EY224 UT WOS:A1991EY22400030 ER PT J AU DUBEY, JP COSENZA, SF LIPSCOMB, TP TOPPER, MJ SPEER, CA HOBAN, LD DAVIS, SW KINCAID, AL SEELY, JC MARRS, GE AF DUBEY, JP COSENZA, SF LIPSCOMB, TP TOPPER, MJ SPEER, CA HOBAN, LD DAVIS, SW KINCAID, AL SEELY, JC MARRS, GE TI ACUTE SARCOCYSTOSIS-LIKE DISEASE IN A DOG SO JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION LA English DT Article ID NEOSPORA-CANINUM; DIAGNOSIS C1 MIDCTY VET CLIN,LA PLATA,MD 20646. USAF,INST PATHOL,DEPT VET PATHOL,WASHINGTON,DC 20306. USA,MED RES INST INFECT DIS,DIV PATHOL,FT DETRICK,MD 21702. GLYMONT VET CLIN,INDIANHEAD,MD 20640. MONTANA STATE UNIV,BOZEMAN,MT 59717. VET DIAGNOST SERV,BALTIMORE,MD 21227. PATHCO INC,RES TRIANGLE PK,NC 27709. ROCHE BIOMED LABS,BURLINGTON,NC 27215. RP DUBEY, JP (reprint author), USDA ARS,BELTSVILLE AGR RES CTR,INST LIVESTOCK & POULTRY SCI,ZOONOT DIS LAB,BELTSVILLE,MD 20705, USA. NR 8 TC 11 Z9 11 U1 0 U2 0 PU AMER VETERINARY MEDICAL ASSOC PI SCHAUMBURG PA 1931 N MEACHAM RD SUITE 100, SCHAUMBURG, IL 60173-4360 SN 0003-1488 J9 J AM VET MED ASSOC JI J. Am. Vet. Med. Assoc. PD FEB 1 PY 1991 VL 198 IS 3 BP 439 EP 443 PG 5 WC Veterinary Sciences SC Veterinary Sciences GA EV491 UT WOS:A1991EV49100025 PM 1901306 ER PT J AU DAMATO, JJ OBRYEN, BN FULLER, SA ROBERTS, CR REDFIELD, RR BURKE, DS AF DAMATO, JJ OBRYEN, BN FULLER, SA ROBERTS, CR REDFIELD, RR BURKE, DS TI RESOLUTION OF INDETERMINATE HIV-1 TEST DATA USING THE DEPARTMENT-OF-DEFENSE HIV-1 TESTING PROGRAM SO LABORATORY MEDICINE LA English DT Article AB The Department of Defense HIV-1 Test Program was designed to provide timely, accurate, and cost-effective HIV-1 testing services for military personnel. This program incorporated a comprehensive quality assurance and quality improvement program in conjunction with large-scale commercial contracts. Definitive diagnostic data were provided for all sera, and nondiagnostic data were resolved as either reactive or nonreactive using the described guidelines and test system. The program used Food and Drug Administration (FDA)-approved HIV-1 ELISA and Western blot methodologies in conjunction with CBre3 recombinant protein and radioimmuno-precipitation (RIPA) assays. The program has evaluated over 4.7 million serum samples. The ELISA repeat reactive rate was approximately 0.6%, and when Western blot and CBre3 tests were performed with the specified criteria, nondiagnostic Western blot data were reduced from 10% to 1%. The remaining nondiagnostic serum samples were analyzed with the third confirmatory procedure, RIPA, which successfully resolved all but 19 samples (0.0004%). These remaining samples were eventually resolved when additional serum samples were retested as previously described. The overall HIV-1 prevalence was determined to be 0.33/1,000, and the program at an average test cost of $4.55 successfully identified over 2,500 infected individuals. This testing program, which required the analysis of two separate specimens, had a false-positive rate estimated at 1 in 1,000,000. RP DAMATO, JJ (reprint author), ARMED FORCES INST PATHOL,WALTER REED ARMY INST RES,DIV RETROVIROL,WASHINGTON,DC 20307, USA. OI /0000-0002-5704-8094 NR 0 TC 10 Z9 11 U1 0 U2 0 PU AMER SOC CLIN PATHOLOGISTS PI CHICAGO PA 2100 W HARRISON ST, CHICAGO, IL 60612 SN 0007-5027 J9 LAB MED JI Lab. Med. PD FEB PY 1991 VL 22 IS 2 BP 107 EP 113 PG 7 WC Medical Laboratory Technology SC Medical Laboratory Technology GA ET619 UT WOS:A1991ET61900006 ER PT J AU MEGLIN, AJ BIEDLINGMAIER, JF MIRVIS, SE AF MEGLIN, AJ BIEDLINGMAIER, JF MIRVIS, SE TI 3-DIMENSIONAL COMPUTERIZED-TOMOGRAPHY IN THE EVALUATION OF LARYNGEAL INJURY SO LARYNGOSCOPE LA English DT Article AB A comparison of diagnostic information obtained from the physical examination, conventional two-dimensional axial computerized tomography scanning (2-D CT), and three-dimensional display computerized tomography (3-D CT) was performed in five patients sustaining laryngeal trauma. Four patients had laryngeal fractures and one patient had an incompletely ossified thyroid cartilage (normal variant) simulating a fracture by 2-D CT. Three-dimensional display computerized tomography was found superior to conventional 2-D CT in assessing the presence and nature of the laryngeal injuries while correctly identifying the anatomic variant. C1 WALTER REED ARMY MED CTR,DEPT DIAGNOST RADIOL,WASHINGTON,DC 20307. UNIV MARYLAND HOSP,DIV OTOLARYNGOL,BALTIMORE,MD 21201. MARYLAND INST EMERGENCY MED SERV SYST,DEPT DIAGNOST RADIOL,BALTIMORE,MD. NR 3 TC 27 Z9 27 U1 0 U2 0 PU LARYNGOSCOPE CO PI ST LOUIS PA 10 S BROADWAY 14TH FLOOR, ST LOUIS, MO 63102-1741 SN 0023-852X J9 LARYNGOSCOPE JI Laryngoscope PD FEB PY 1991 VL 101 IS 2 BP 202 EP 207 PG 6 WC Medicine, Research & Experimental; Otorhinolaryngology SC Research & Experimental Medicine; Otorhinolaryngology GA EX029 UT WOS:A1991EX02900018 PM 1992274 ER PT J AU BULUSU, S AXENROD, T LIANG, B YUAN, L AF BULUSU, S AXENROD, T LIANG, B YUAN, L TI AN NMR-STUDY OF THE HYDROXYLAMINE-INDUCED DENITRATION OF NITROCELLULOSE, NITROAMYLOSE AND SOME MODEL MONOSACCHARIDE NITRATE ESTERS SO MAGNETIC RESONANCE IN CHEMISTRY LA English DT Article DE TRINITROCELLULOSE; TRINITROAMYLOSE; MONOSACCHARIDE NITRATES; HYDROXYLAMINE DENITRATION; N-15-O-C-H-1 SHIFT CORRELATIONS ID NUCLEAR MAGNETIC-RESONANCE; CELLULOSE NITRATES; C-13; SPECTROSCOPY; SPECTRA AB The previously known method of partial denitration of trinitrocellulose by hydroxylamine in pyridine was further investigated by NMR and applied to trinitroamylose and several other monosaccharide nitrates to study its selectivity. The sites of denitration were determined in each case using C-13 and N-15 NMR and, in most cases, by 2D homo- and hetero-nuclear (N-15-O-C-H-1 and C-13-H-1) chemical shift correlations. The results indicate that denitration of the polysaccharide nitrates is a highly regiospecific reaction occurring at the 2-position only, whereas with the monosaccharide nitrates denitration takes place with less selectivity, at the 4-position predominantly, and to a lesser extent at the 3-position. C1 CUNY CITY COLL,DEPT CHEM,NEW YORK,NY 10031. USA,CTR DEV & ENGN,ARMAMENTS RES,PICATINNY ARSENAL,NJ 07806. NR 20 TC 0 Z9 0 U1 2 U2 5 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0749-1581 J9 MAGN RESON CHEM JI Magn. Reson. Chem. PD FEB PY 1991 VL 29 IS 2 BP 168 EP 177 DI 10.1002/mrc.1260290214 PG 10 WC Chemistry, Multidisciplinary; Chemistry, Physical; Spectroscopy SC Chemistry; Spectroscopy GA EX933 UT WOS:A1991EX93300013 ER PT J AU BLUM, G OTT, M CROSS, A HACKER, J AF BLUM, G OTT, M CROSS, A HACKER, J TI VIRULENCE DETERMINANTS OF ESCHERICHIA-COLI O6 EXTRAINTESTINAL ISOLATES ANALYZED BY SOUTHERN HYBRIDIZATIONS AND DNA LONG-RANGE MAPPING TECHNIQUES SO MICROBIAL PATHOGENESIS LA English DT Article DE ESCHERICHIA-COLI SEROTYPE O6; EXTRAINTESTINAL ISOLATES; VIRULENCE FACTORS; GENE PROBES; DNA LONG RANGE MAPPING; EPIDEMIOLOGY ID URINARY-TRACT INFECTIONS; S-FIMBRIAL ADHESIN; GEL-ELECTROPHORESIS; MANNOSE-RESISTANT; TYPE-1C FIMBRIAE; HEMOLYSIN GENES; EXPRESSION; STRAINS; PLASMID; IDENTIFICATION C1 UNIV WURZBURG,INST GENET & MIKROBIOL,RONTGENRING 11,W-8700 WURZBURG,GERMANY. WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,WASHINGTON,DC 20307. NR 48 TC 24 Z9 24 U1 0 U2 0 PU ACADEMIC PRESS LTD PI LONDON PA 24-28 OVAL RD, LONDON, ENGLAND NW1 7DX SN 0882-4010 J9 MICROB PATHOGENESIS JI Microb. Pathog. PD FEB PY 1991 VL 10 IS 2 BP 127 EP 136 DI 10.1016/0882-4010(91)90073-J PG 10 WC Immunology; Microbiology SC Immunology; Microbiology GA FN888 UT WOS:A1991FN88800005 PM 1679907 ER PT J AU FORSYTHE, MA AF FORSYTHE, MA TI PROFESSIONAL NURSE INFORMATION DAY - A RECRUITMENT STRATEGY FOR REGISTERED NURSES SO MILITARY MEDICINE LA English DT Article AB The shortage of and demand for professional registered nurses is growing at an ever-increasing rate. Military facilities must consider alternative strategies for recruiting these professionals into their staffs even in the midst of worsening budget and personnel constraints. One idea is reported here that proved successful for a medical center overseas with no money expenditure. Recommendations for repetitions of a similar program are included. RP FORSYTHE, MA (reprint author), USA,MEDDAC,BOX 59,FT SILL,OK 73503, USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD FEB PY 1991 VL 156 IS 2 BP 58 EP 59 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA EX583 UT WOS:A1991EX58300004 PM 1900589 ER PT J AU HOOD, CH AF HOOD, CH TI THE UNITED-STATES-ARMY MEDICAL DEPARTMENT IN LOW-INTENSITY CONFLICT SO MILITARY MEDICINE LA English DT Article AB For 30 years, in rural Texas, rural Kentucky, and in the Army, I have observed a variety of efforts aimed at changing people's health. Recently I participated in one large effort (USNS MERCY), commanded a second (MED EL, JTF-Bravo, Honduras), was "neighbor" and visitor to a third (Medical Assistance Team in El Salvador), and had staff level interface with others (Ahuas Tara 88, Fuertes Caminos 88, and Special Operating Forces Humanitarian Assistance Team, all in Honduras). This article speaks to the philosophies which I believe drive, or should drive, these initiatives. Other articles will explore individual iterations. RP HOOD, CH (reprint author), USA,ACAD HLTH SCI,FT SAM HOUSTON,TX 78234, USA. NR 0 TC 2 Z9 2 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD FEB PY 1991 VL 156 IS 2 BP 64 EP 67 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA EX583 UT WOS:A1991EX58300006 PM 2002889 ER PT J AU BORSAYTRINDLE, LA PASS, CM GILZEAN, SM AF BORSAYTRINDLE, LA PASS, CM GILZEAN, SM TI UNPLANNED PREGNANCY AMONG ACTIVE-DUTY ARMY FEMALES AS A READINESS ISSUE SO MILITARY MEDICINE LA English DT Article AB Unplanned pregnancy creates significant problems for active-duty female soldiers and also elicits concern among military leaders when planning for mobilization. The purpose of this three-group comparative survey is to ascertain probable reasons for unplanned pregnancy occurrence that will be useful in developing appropriate interventions directed at decreasing the incidence of such pregnancies. Active-duty female soldiers (n = 112) in-processing at a large military installation responded to a 41-item questionnaire focused on respondents' reproductive histories, beliefs and knowledge about contraception, and contraceptive use. Descriptive statistics, the Kruskal-Wallis One-Way Analysis of Variance, and Chi-Square non-parametric statistical tests were used for analysis of the data. Findings revealed that when compared to the two post-adolescent groups, the adolescent female soldiers reported: (a) a greater number of sexual partners, (b) greater frequency of intercourse, (c) less knowledge about the reproductive cycle, and (d) greater non-use of any birth control method. RP BORSAYTRINDLE, LA (reprint author), USA,NURSE CORPS,CPT,FT GORDON,GA 30905, USA. NR 0 TC 14 Z9 14 U1 1 U2 4 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD FEB PY 1991 VL 156 IS 2 BP 82 EP 86 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA EX583 UT WOS:A1991EX58300011 PM 1900595 ER PT J AU DRABICK, JJ HORNING, VL LENNOX, JL COYNE, PE OSTER, CN KNIGHT, RD DILLARD, TA FULLER, SA DAMATO, JJ BURKE, DS AF DRABICK, JJ HORNING, VL LENNOX, JL COYNE, PE OSTER, CN KNIGHT, RD DILLARD, TA FULLER, SA DAMATO, JJ BURKE, DS TI A RETROSPECTIVE ANALYSIS OF DISEASES ASSOCIATED WITH INDETERMINATE HIV WESTERN-BLOT PATTERNS SO MILITARY MEDICINE LA English DT Article AB Some individuals possess antibodies which react to HIV-1 Western blot proteins in patterns not diagnostic for HIV infection. A retrospective chart review of patients exhibiting such indeterminate HIV Western blots was performed in comparison to a control cohort of sex-and age-matched individuals from the same population of HIV-negative blots to determine if such blots were associated with any specific disease states. Twenty such patients with 25 indeterminate blots among them were found in a total population of 816 (2.5%). GAG-only (core) Western blots comprised the majority 84% (21/25). An indeterminate blot was statistically associated with Hashimoto's thyroiditis (p < 0.01) and non-Hodgkin's lymphoma (p < 0.05). Kikuchi's disease and malignant histiocytosis were associated but the numbers were too small to reach statistical significance. The possibility that these disease are caused by novel retroviruses, cross-reactive with HIV-1, is discussed in lieu of these findings. RP DRABICK, JJ (reprint author), WALTER REED ARMY MED CTR,INFECT DIS SERV,WASHINGTON,DC 20307, USA. RI Lennox, Jeffrey/D-1654-2014; OI Lennox, Jeffrey/0000-0002-2064-5565; /0000-0002-5704-8094 NR 0 TC 10 Z9 10 U1 0 U2 1 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD FEB PY 1991 VL 156 IS 2 BP 93 EP 96 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA EX583 UT WOS:A1991EX58300013 PM 1900597 ER PT J AU VOORHIS, DL DILLON, S FORMAL, SB ISBERG, RR AF VOORHIS, DL DILLON, S FORMAL, SB ISBERG, RR TI AN O-ANTIGEN CAN INTERFERE WITH THE FUNCTION OF THE YERSINIA-PSEUDOTUBERCULOSIS INVASION PROTEIN SO MOLECULAR MICROBIOLOGY LA English DT Article ID ESCHERICHIA-COLI K-12; CULTURED MAMMALIAN-CELLS; SHIGELLA-FLEXNERI; MOLECULAR-CLONING; EPITHELIAL-CELLS; PLASMID; DETERMINANTS; LIPOPOLYSACCHARIDE; PENETRATION; SALMONELLA AB Escherichia coli strains harbouring the Yersinia pseudotuberculosis inv gene are able to enter cultured mammalial cells. We show here that this property is not shared by all enteric bacteria, since Shigella flexneri 2a cured of its virulence-associated plasmid and harbouring the inv gene is unable to enter mammalian cells efficiently. Mapping studies showed that the region of the chromosome responsible for this phenotype includes rfaB, a locus involved in the production of O antigen. S. flexneri 2a strains that express O antigen were unable to enter mammalian cells, even though invasin was efficiently expressed and localized, showing that this structure interferes with invasin activity. The O antigen either masks invasin or sterically hinders the ability of the mammalian cell receptor to bind this protein. C1 TUFTS UNIV,SCH MED,DEPT MOLEC BIOL & MICROBIOL,136 HARRISON AVE,BOSTON,MA 02111. TUFTS UNIV,SCH MED,HOWARD HUGHES MED INST,BOSTON,MA 02111. WALTER REED ARMY MED CTR,DEPT ENTER INFECT,WASHINGTON,DC 20307. FU NIAID NIH HHS [R01-AI23538] NR 38 TC 13 Z9 13 U1 2 U2 6 PU BLACKWELL SCIENCE LTD PI OXFORD PA OSNEY MEAD, OXFORD, OXON, ENGLAND OX2 0EL SN 0950-382X J9 MOL MICROBIOL JI Mol. Microbiol. PD FEB PY 1991 VL 5 IS 2 BP 317 EP 325 DI 10.1111/j.1365-2958.1991.tb02112.x PG 9 WC Biochemistry & Molecular Biology; Microbiology SC Biochemistry & Molecular Biology; Microbiology GA EZ838 UT WOS:A1991EZ83800010 PM 1710312 ER PT J AU BOUCHARD, CS CHACKO, B CUPPLES, HP CAVANAGH, HD MATHERS, WD AF BOUCHARD, CS CHACKO, B CUPPLES, HP CAVANAGH, HD MATHERS, WD TI SURGICAL-TREATMENT FOR A CASE OF POSTOPERATIVE PSEUDALLESCHERIA BOYDII ENDOPHTHALMITIS SO OPHTHALMIC SURGERY AND LASERS LA English DT Article ID PETRIELLIDIUM-BOYDII; ALLESCHERIA-BOYDII; INVITRO AB Pseudallescheria boydii (P. boydii) is an uncommon ocular pathogen which previously has been identified in only 10 of 905 fungal isolates identified by the Sid Richardson Microbiology Laboratory at the Cullen Eye Institute of Baylor College of Medicine. Furthermore, only one case of postoperative P. boydii endophthalmitis1 and four cases of endogenous P. boydii endophthalmitis have been reported.2.5 Three of the four patients with endogenous endophthalmitis died within 4 weeks of diagnosis. We describe a second case of postoperative endophthalmitis due to this fungus. The infection was successfully eradicated following vitrectomy, corneoscleral resection, and patch graft, in addition to intraocular, topical, and oral antifungal medication. Although in vitro sensitivities are variable, P. boydii is known to be relatively resistant to amphotericin B. This points to the importance of proper cultures and sensitivities when treating cases of suspected fungal endophthalmitis. Unfortunately, the patient's eye became phthisical 6 months following the initial intervention. C1 GEORGETOWN UNIV,MED CTR,CTR SIGHT,WASHINGTON,DC 20007. BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234. RP BOUCHARD, CS (reprint author), LOYOLA UNIV,MED CTR,DEPT OPHTHALMOL,2160 S FIRST AVE,MAYWOOD,IL 60152, USA. NR 15 TC 8 Z9 8 U1 0 U2 0 PU SLACK INC PI THOROFARE PA 6900 GROVE RD, THOROFARE, NJ 08086 SN 0022-023X J9 OPHTHALMIC SURG LAS JI Ophthalmic Surg. Lasers PD FEB PY 1991 VL 22 IS 2 BP 98 EP 101 PG 4 WC Ophthalmology; Surgery SC Ophthalmology; Surgery GA FC955 UT WOS:A1991FC95500009 PM 2038484 ER PT J AU BENNETT, LF AF BENNETT, LF TI KNOWLEDGE-BASED EVALUATION OF THE SEGMENTATION COMPONENT IN AUTOMATIC PATTERN-RECOGNITION SYSTEMS SO OPTICAL ENGINEERING LA English DT Article DE PATTERN RECOGNITION; REAL-TIME IMAGING SYSTEMS; FORWARD-LOOKING INFRARED IMAGERY; IMAGE SEGMENTATION; SEGMENTATION ACCURACY; TRUTHING PROCEDURES; ERROR MEASURES; ALGORITHM EVALUATION ID SCENE SEGMENTATION; ERROR MEASURES; MODEL AB Advances in segmentation algorithm design can be guided by the development of uniform methods for segmentation accuracy measurement. A representative set of approaches to segmentation accuracy measurement is presented, and performance is demonstrated on a prototype set of segmented imagery. Unlike the evaluation of the detection and classification phases of the automatic target recognition (ATR) process, segmentation evaluation remains an ill-defined problem in the absence of an absolute, correct segmentation reference. A dynamic assessment of image truth from multiple sources can reduce the uncertainty of the target reference. We describe two approaches to the measurement of segmentation accuracy that make use of internal characteristics of the image in the target reference. These measures begin to demonstrate that the truthing procedure in real-time systems is not necessarily a single-pass reference to a prior model of image truth, but an evolving set of criteria utilizing information from the unprocessed image and from intermediate stages of the segmentation process. Sample measures based on an independent determination of image truth, i.e., hand segmentation of the target regions by the human operator or the manipulation of models of expected target configuration, are also presented. The form of the sample measures can be optimized and integrated into a dynamic truthing process to achieve real-time management of the segmentation phase in ATR systems. RP BENNETT, LF (reprint author), USA,COMMUN ELECTR COMMAND,CTR NIGHT VIS & ELECTROOPT,AMSEL RD NV SPD,FT BELVOIR,VA 22060, USA. NR 22 TC 1 Z9 4 U1 0 U2 0 PU SOC PHOTO-OPT INSTRUM ENG PI BELLINGHAM PA PO BOX 10, BELLINGHAM, WA 98227-0010 SN 0091-3286 J9 OPT ENG JI Opt. Eng. PD FEB PY 1991 VL 30 IS 2 BP 154 EP 165 DI 10.1117/12.55782 PG 12 WC Optics SC Optics GA EX618 UT WOS:A1991EX61800004 ER PT J AU JUTAMULIA, S STORTI, GM SEIDERMAN, WM LINDMAYER, J GREGORY, DA AF JUTAMULIA, S STORTI, GM SEIDERMAN, WM LINDMAYER, J GREGORY, DA TI INFRARED SIGNAL-PROCESSING USING A LIQUID-CRYSTAL TELEVISION SO OPTICAL ENGINEERING LA English DT Article DE LIQUID CRYSTAL TELEVISION; INFRARED SIGNAL PROCESSING; INFRARED SCENE SIMULATOR; COMPACT JOINT TRANSFORM CORRELATOR; ELECTRON TRAPPING MATERIALS ID CORRELATOR AB The ability of an inexpensive liquid crystal television to modulate both coherent and incoherent infrared light is reported. Experiments demonstrating light modulation for wavelengths between 0.8-mu-m and 1.1-mu-m have been performed. Potential applications to dynamic IR scene simulators, compact joint transform correlators, and novel electron trapping processors are described. C1 USA, MISSILE COMMAND, RES DIRECTORATE, REDSTONE ARSENAL, AL 35898 USA. RP JUTAMULIA, S (reprint author), QUANTEX CORP, 2 RES COURT, ROCKVILLE, MD 20850 USA. NR 16 TC 4 Z9 4 U1 0 U2 0 PU SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS PI BELLINGHAM PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA SN 0091-3286 EI 1560-2303 J9 OPT ENG JI Opt. Eng. PD FEB PY 1991 VL 30 IS 2 BP 178 EP 182 DI 10.1117/12.55785 PG 5 WC Optics SC Optics GA EX618 UT WOS:A1991EX61800007 ER PT J AU LIN, AJ AF LIN, AJ TI SYNTHESIS OF 1-(2-PYRIDINE-1-OXIDE)-2-(1-METHYL-2-PYRIDINIUM)-ETHANE CHLORIDE SO ORGANIC PREPARATIONS AND PROCEDURES INTERNATIONAL LA English DT Note RP LIN, AJ (reprint author), WALTER REED ARMY MED CTR,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307, USA. NR 3 TC 0 Z9 0 U1 0 U2 0 PU ORGANIC PREP PROCEDURES INC PI NEWTON HIGHLANDS PA PO BOX 9, NEWTON HIGHLANDS, MA 02161 SN 0030-4948 J9 ORG PREP PROCED INT JI Org. Prep. Proced. Int. PD FEB PY 1991 VL 23 IS 1 BP 114 EP 115 PG 2 WC Chemistry, Organic SC Chemistry GA EW370 UT WOS:A1991EW37000006 ER PT J AU WISWELL, TE AF WISWELL, TE TI EARLY INTUBATION AND MAS - REPLY SO PEDIATRICS LA English DT Letter RP WISWELL, TE (reprint author), WALTER REED ARMY MED CTR,NEWBORN MED SERV,WASHINGTON,DC 20307, USA. NR 3 TC 0 Z9 0 U1 0 U2 0 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD, ELK GROVE VILLAGE, IL 60007-1098 SN 0031-4005 J9 PEDIATRICS JI Pediatrics PD FEB PY 1991 VL 87 IS 2 BP 269 EP 269 PG 1 WC Pediatrics SC Pediatrics GA EW342 UT WOS:A1991EW34200035 ER PT J AU WAGAMAN, JD BARABASZ, AF BARABASZ, M AF WAGAMAN, JD BARABASZ, AF BARABASZ, M TI FLOTATION REST AND IMAGERY IN THE IMPROVEMENT OF COLLEGIATE BASKETBALL PERFORMANCE SO PERCEPTUAL AND MOTOR SKILLS LA English DT Article C1 WASHINGTON STATE UNIV,HYPNOSIS & RESTRICTED ENVIRONM STIMULAT LAB,CLEVELAND HALL,PULLMAN,WA 99164. USA,FT SAM HOUSTON,TX 78234. NR 7 TC 11 Z9 11 U1 0 U2 1 PU PERCEPTUAL MOTOR SKILLS PI MISSOULA PA PO BOX 9229, MISSOULA, MT 59807 SN 0031-5125 J9 PERCEPT MOTOR SKILL JI Percept. Mot. Skills PD FEB PY 1991 VL 72 IS 1 BP 119 EP 122 DI 10.2466/PMS.72.1.119-122 PG 4 WC Psychology, Experimental SC Psychology GA FD072 UT WOS:A1991FD07200025 ER PT J AU MEREISH, KA BUNNER, DL RAGLAND, DR CREASIA, DA AF MEREISH, KA BUNNER, DL RAGLAND, DR CREASIA, DA TI PROTECTION AGAINST MICROCYSTIN-LR-INDUCED HEPATOTOXICITY BY SILYMARIN - BIOCHEMISTRY, HISTOPATHOLOGY, AND LETHALITY SO PHARMACEUTICAL RESEARCH LA English DT Article DE ALANINE AMINOTRANSFERASE; FLAVONOID; HEPATIC NECROSIS; HEPATOTOXIN; LACTATE DEHYDROGENASE; MICROCYSTIN-LR; SILYMARIN; SORBITOL DEHYDROGENASE ID LIPID-PEROXIDATION; PEPTIDE TOXIN; AERUGINOSA; HEPATOCYTES; RATS; INVITRO; INVIVO; ACTIN AB Microcystin-LR, a cyclic heptapeptide synthesized by the blue-green algae, Microcystis aeruginosa, is a potent hepatotoxin. Pathological examination of livers from mice and rats that reveived microcystin-LR revealed severe, peracute, diffuse, centrilobular hepatocellular necrosis, and hemorrhage. These changes were correlated with increased serum activities of sorbitol dehydrogenase, alanine aminotransferase, and lactate dehydrogenase. Pretreatment of either rats or mice with a single dose of silymarin, a flavonolignane isolated from the wild artichoke (Silybum marianum L. Gaertn), completely abolished the lethal effects, pathological changes, and significantly decreased the levels of serum enzymes induced by microcystin-LR intoxication. C1 USA,MED RES INST INFECT DIS,DIV PATHOL,FREDERICK,MD 21702. USA,MED RES INST INFECT DIS,DIV PATHOPHYSIOL,FREDERICK,MD 21702. RP MEREISH, KA (reprint author), USA,MED RES INST INFECT DIS,DIV MED,FT DETRICK,FREDERICK,MD 21702, USA. NR 21 TC 74 Z9 76 U1 2 U2 7 PU PLENUM PUBL CORP PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 SN 0724-8741 J9 PHARMACEUT RES JI Pharm. Res. PD FEB PY 1991 VL 8 IS 2 BP 273 EP 277 DI 10.1023/A:1015868809990 PG 5 WC Chemistry, Multidisciplinary; Pharmacology & Pharmacy SC Chemistry; Pharmacology & Pharmacy GA EX006 UT WOS:A1991EX00600025 PM 1902564 ER PT J AU RAMESH, R RAVI, TS HWANG, DM CHANG, CC INAM, A VENKATESAN, T WU, XD MUENCHAUSEN, RE FOLTYN, S NOGAR, NS AF RAMESH, R RAVI, TS HWANG, DM CHANG, CC INAM, A VENKATESAN, T WU, XD MUENCHAUSEN, RE FOLTYN, S NOGAR, NS TI MICROSTRUCTURAL EVOLUTION OF LASER DEPOSITED SUPERCONDUCTING Y-BA-CU-O FILMS - EFFECT OF DEPOSITION RATE SO PHYSICA C LA English DT Article ID SRTIO3 AB The microstructure of laser deposited, superconducting Y-Ba-Cu-O thin films grown on [001] SrTiO3 substrates has been characterized as a function of laser pulse rate. Over a range of deposition rates from 1-150 angstrom/s, the films consist mainly of the c-axis oriented epitaxial, YBa2Cu3O7-x phase with a high density of polytypoidic stacking defects. High transport critical current densities, J(c), are attributed to the retention of the primarily c-axis oriented microstructure along with the distribution of stacking defects that provide good flux pinning. At higher deposition rates we observe new growth directions, specifically the a,b-axis and the [103] growth directions are favored. We conclude that within the deposition rate range of 1-150 angstrom/s, there is no significant fundamental change in microstructure except for outgrowth formation. Therefore, we are optimistic that much higher rates can be attained in the near future, although controlling the outgrowth formation may be difficult. C1 RUTGERS STATE UNIV,PISCATAWAY,NJ 08854. UNIV CALIF LOS ALAMOS SCI LAB,ERDC,LOS ALAMOS,NM 87545. RP RAMESH, R (reprint author), BELLCORE,RED BANK,NJ 07701, USA. RI Venkatesan, Thirumalai/E-1667-2013 NR 16 TC 22 Z9 22 U1 0 U2 3 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0921-4534 J9 PHYSICA C JI Physica C PD FEB 1 PY 1991 VL 173 IS 3-4 BP 163 EP 172 DI 10.1016/0921-4534(91)90364-5 PG 10 WC Physics, Applied SC Physics GA EY245 UT WOS:A1991EY24500006 ER PT J AU WALKER, EH AF WALKER, EH TI MARIC,MILEVA RELATIVISTIC ROLE SO PHYSICS TODAY LA English DT Letter C1 USA,BALLIST RES LABS,ABERDEEN PROVING GROUND,MD 21005. RP WALKER, EH (reprint author), WALKER CANC RES INST,EDGEWOOD,MD, USA. NR 38 TC 0 Z9 0 U1 1 U2 1 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0031-9228 J9 PHYS TODAY JI Phys. Today PD FEB PY 1991 VL 44 IS 2 BP 122 EP 124 DI 10.1063/1.2810013 PG 3 WC Physics, Multidisciplinary SC Physics GA EX276 UT WOS:A1991EX27600029 ER PT J AU CONLEY, J JUARBE, C PATOW, CA ANGEL, MF AF CONLEY, J JUARBE, C PATOW, CA ANGEL, MF TI METASTATIC MELANOMA TO THE FACIAL-NERVE SO PLASTIC AND RECONSTRUCTIVE SURGERY LA English DT Article C1 WALTER REED ARMY MED CTR,DEPT OTOLARYNGOL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT HEAD & NECK SURG,WASHINGTON,DC 20307. COLUMBIA PRESBYTERIAN MED CTR,NEW YORK,NY 10032. ST VINCENTS HOSP & MED CTR,HEAD & NECK SURG SERV,NEW YORK,NY 10011. UNIV VIRGINIA,DEPT PLAST SURG,CHARLOTTESVILLE,VA 22903. NR 5 TC 4 Z9 4 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0032-1052 J9 PLAST RECONSTR SURG JI Plast. Reconstr. Surg. PD FEB PY 1991 VL 87 IS 2 BP 341 EP 345 DI 10.1097/00006534-199102000-00018 PG 5 WC Surgery SC Surgery GA EV356 UT WOS:A1991EV35600018 PM 1989027 ER PT J AU KROENKE, K AF KROENKE, K TI CHRONIC FATIGUE SYNDROME - IS IT REAL SO POSTGRADUATE MEDICINE LA English DT Article ID EPSTEIN-BARR VIRUS; FREQUENCY; SYMPTOMS; CARE AB Because the exact cause of chronic fatigue syndrome is still unknown, management can be a frustrating proposition for both patient and physician. Each case should be carefully evaluated for possible organic and psychiatric factors. Dr Kroenke reviews the current controversy over etiology and suggests an approach to management. C1 WALTER REED ARMY MED CTR,FELLOWSHIP PROGRAM GEN INTERNAL MED,WASHINGTON,DC 20307. RP KROENKE, K (reprint author), UNIFORMED SERV UNIV HLTH SCI,DEPT MED,4301 JONES BRIDGE RD,BETHESDA,MD 20814, USA. NR 22 TC 8 Z9 8 U1 0 U2 0 PU MCGRAW HILL HEALTHCARE PUBLICATIONS PI MINNEAPOLIS PA 4530 WEST 77TH ST, MINNEAPOLIS, MN 55435-5000 SN 0032-5481 J9 POSTGRAD MED JI Postgrad. Med. PD FEB 1 PY 1991 VL 89 IS 2 BP 44 EP & PG 0 WC Medicine, General & Internal SC General & Internal Medicine GA EW731 UT WOS:A1991EW73100009 PM 1990396 ER PT J AU PRIDHAM, KF LYTTON, D CHANG, AS RUTLEDGE, D AF PRIDHAM, KF LYTTON, D CHANG, AS RUTLEDGE, D TI EARLY POSTPARTUM TRANSITION - PROGRESS IN MATERNAL IDENTITY AND ROLE ATTAINMENT SO RESEARCH IN NURSING & HEALTH LA English DT Article ID PARENTS BELIEFS; SELF-EFFICACY; SUPPORT; INFANT; BIRTH C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. BONIFACE GEN HOSP,WINNIPEG,MANITOBA,CANADA. RP PRIDHAM, KF (reprint author), UNIV WISCONSIN,SCH NURSING,DEPT FAMILY MED & PRACTICE,600 HIGHLAND AVE,MADISON,WI 53706, USA. NR 42 TC 15 Z9 15 U1 2 U2 3 PU JOHN WILEY & SONS INC PI NEW YORK PA 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0160-6891 J9 RES NURS HEALTH JI Res. Nurs. Health PD FEB PY 1991 VL 14 IS 1 BP 21 EP 31 DI 10.1002/nur.4770140105 PG 11 WC Nursing SC Nursing GA EW217 UT WOS:A1991EW21700003 PM 2017579 ER PT J AU COLBECK, SC AF COLBECK, SC TI THE LAYERED CHARACTER OF SNOW COVERS SO REVIEWS OF GEOPHYSICS LA English DT Review ID WETTING FRONT ADVANCE; WATER-FLOW; DRY SNOW; MICROWAVE; METAMORPHISM; MELTWATER; SIMULATION; GROWTH; MEDIA; MODEL AB Snow studies have generally ignored the layered nature of snow covers. Having achieved a good understanding of the properties and processes in homogeneous snow, snow scientists should develop more insight into the evolution of the layers and their effects on overall snow response. Many of the outstanding problems in snow studies can only be solved by dealing with snow as a layered medium. The various mechanisms by which layers are generated, their effects, and some of the outstanding research problems are described here. RP COLBECK, SC (reprint author), USA,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. OI Tranter, Martyn/0000-0003-2071-3094 NR 98 TC 99 Z9 103 U1 1 U2 12 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 SN 8755-1209 J9 REV GEOPHYS JI Rev. Geophys. PD FEB PY 1991 VL 29 IS 1 BP 81 EP 96 DI 10.1029/90RG02351 PG 16 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA EY103 UT WOS:A1991EY10300004 ER PT J AU GRAHAM, CP AF GRAHAM, CP TI THE BRAZILIAN SPACE PROGRAM - AN OVERVIEW SO SPACE POLICY LA English DT Article RP GRAHAM, CP (reprint author), US MIL ACAD,DEPT GEOG & ENVIRONM ENGN,W POINT,NY 10996, USA. NR 8 TC 0 Z9 0 U1 0 U2 0 PU BUTTERWORTH-HEINEMANN LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB SN 0265-9646 J9 SPACE POLICY JI Space Policy PD FEB PY 1991 VL 7 IS 1 BP 72 EP 76 DI 10.1016/0265-9646(91)90048-M PG 5 WC International Relations; Social Sciences, Interdisciplinary SC International Relations; Social Sciences - Other Topics GA EX860 UT WOS:A1991EX86000009 ER PT J AU SHIH, TM WHALLEY, CE VALDES, JJ AF SHIH, TM WHALLEY, CE VALDES, JJ TI A COMPARISON OF CHOLINERGIC EFFECTS OF HI-6 AND PRALIDOXIME-2-CHLORIDE (2-PAM) IN SOMAN POISONING SO TOXICOLOGY LETTERS LA English DT Article DE SOMAN; 2-PAM; HI-6; ATROPINE; ACETYLCHOLINE; CHOLINESTERASE; CHOLINE UPTAKE; MUSCARINIC RECEPTOR BINDING; PROTECTIVE RATIO; CHOLINE; ORGANOPHOSPHATE ID BRAIN ACETYLCHOLINE; RAT-BRAIN; HS-6; CHOLINESTERASE; REACTIVATION; OXIMES; ATROPINE; BLOOD; AREAS; INTOXICATION AB The effects of HI-6 and pralidoxime chloride (2-PAM) on soman-induced lethality, time to death and several cholinergic parameters in rats were compared to understand the beneficial action of HI-6. Treatment with atropine sulfate (ATS) or HI-6 alone protected against 1.2 and 2.5 LD50S of soman respectively, whereas 2-PAM or methylated atropine (AMN) alone afforded no protection. Addition of ATS, but not AMN, to HI-6-treated rats enhanced the protection from 2.5 to 5.5 LD50s. HI-6 increased the time-to-death, while 2-PAM had no effect; a combination of HI-6 and ATS provided the most significant increase in time-to-death. Cholinesterase (ChE) activity was not altered in any tissue by ATS, HI-6 or 2-PAM treatment individually, but was markedly inhibited in all tissues by 100-mu-g/kg of soman. In soman-poisoned rats, the HI-6, but not the 2-PAM, group had significantly higher levels of ChE in blood and other peripheral tissues than did the group given soman alone. Neither HI-6 nor 2-PAM affected soman-inhibited ChE in the brain. Additional ATS treatment had no effect on ChE activity. HI-6 and 2-PAM neither modified baseline brain acetylcholine (ACh) or choline (Ch) levels nor protected against soman-induced ACh or Ch elevation. 2-PAM exhibited a 4-fold more potent in vitro inhibition of H-3-quinuclidinyl benzilate (H-3-QNB) binding and sodium-dependent high-affinity Ch uptake (HACU) than did HI-6 in brain tissues. The findings that 2-PAM is a more potent in vitro inhibitor of muscarinic receptor binding and HACU than HI-6, and yet neither elevates ChE activity in the periphery nor protects rats against soman poisoning, indicate the importance of higher ChE activity in the periphery of HI-6-treated rats. Maintenance by HI-6 of a certain amount of active ChE in the periphery appears to be important for survival after soman exposure. C1 DEV & ENGN CTR,CHEM RES,ABERDEEN PROVING GROUND,MD. RP SHIH, TM (reprint author), USA,MED RES INST CHEM DEF,SGRD UV PB,ABERDEEN PROVING GROUND,MD 21010, USA. NR 73 TC 53 Z9 54 U1 0 U2 3 PU ELSEVIER SCI IRELAND LTD PI CLARE PA CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE, IRELAND SN 0378-4274 J9 TOXICOL LETT JI Toxicol. Lett. PD FEB PY 1991 VL 55 IS 2 BP 131 EP 147 PG 17 WC Toxicology SC Toxicology GA EZ226 UT WOS:A1991EZ22600001 PM 1998202 ER PT J AU CAUCHI, MR HENCHAL, EA WRIGHT, PJ AF CAUCHI, MR HENCHAL, EA WRIGHT, PJ TI THE SENSITIVITY OF CELL-ASSOCIATED DENGUE VIRUS PROTEINS TO TRYPSIN AND THE DETECTION OF TRYPSIN-RESISTANT FRAGMENTS OF THE NONSTRUCTURAL GLYCOPROTEIN NS1 SO VIROLOGY LA English DT Article ID WEST NILE VIRUS; NEW-GUINEA-C; AMINO-ACID SEQUENCE; YELLOW-FEVER VIRUS; STRUCTURAL PROTEINS; NUCLEOTIDE-SEQUENCE; MEMBRANE-PROTEIN; MONOCLONAL-ANTIBODIES; TYPE-2 VIRUS; GENOME C1 MONASH UNIV,DEPT MICROBIOL,CLAYTON,VIC 3168,AUSTRALIA. WALTER REED ARMY MED CTR,DEPT VIRUS DIS,WASHINGTON,DC 20307. NR 29 TC 22 Z9 22 U1 1 U2 1 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0042-6822 J9 VIROLOGY JI Virology PD FEB PY 1991 VL 180 IS 2 BP 659 EP 667 DI 10.1016/0042-6822(91)90079-Q PG 9 WC Virology SC Virology GA ET825 UT WOS:A1991ET82500020 PM 1824904 ER PT J AU PRICE, RW AF PRICE, RW TI WEAPON SYSTEM RELIABILITY AND MAINTAINABILITY - INCREASING THEIR VISIBILITY WITH DECISION MAKERS SO PROCEEDINGS ANNUAL RELIABILITY AND MAINTAINABILITY SYMPOSIUM LA English DT Article; Proceedings Paper CT 1991 ANNUAL SYMP ON RELIABILITY AND MAINTAINABILITY CY JAN 29-31, 1991 CL ORLANDO, FL SP IEEE, AMER SOC QUAL CONTROL, SOC RELIAB ENGINEERS, SOC LOGIST ENGINEERS, SYST SAFETY SOC, INST IND ENGINEERS DE COMMUNICATION; IMPACT; MANAGEMENT; WEAPON SYSTEM; DECISION MAKERS; EXECUTIVE AB Army R&M engineers have traditionally used the technical language of their profession in communicating with management and senior executives. This may be a key factor in weapon system R&M receiving less consideration at top decision levels than cost, schedule and performance. Visibility with top Army executives is enhanced by documenting the value added or return on investment associated with a system's R&M characteristics. Numerical values of reliability and maintainability are not nearly as important as their actual meaning to the decision maker and ultimate user. Translation of technical R&M terminology into non-technical concepts and language appears to increase the likelihood of attracting senior decision maker attention. Two areas of universal understanding among Army executives are impacts on combat capability and on operating and support (O&S) costs. During times of restricted funding, improved R&M offers one of the few ways to improve these, or at least sustain present levels. Relating R&M requirements and performance to these areas helps insure a common base of understanding and increases visibility of R&M during the decision process. Further investigation is needed to find and refine new ways of effectively communicating R&M information to top decision makers. Such refinement should focus on improving communication for increased visibility and on resolving conflicts arising from these approaches. Such conflict may otherwise erase benefits gained if confusion is introduced elsewhere in the decision process. RP PRICE, RW (reprint author), USA,COMBINED ARMS SUPPORT COMMAND,FT LEE,VA 23801, USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0149-144X J9 P ANNU REL MAINT SYM JI Proc. Annu. Reliab. Maintainab. Symp. PD JAN 29 PY 1991 IS SYM BP 82 EP 84 DI 10.1109/ARMS.1991.154418 PG 3 WC Engineering, Multidisciplinary; Engineering, Industrial SC Engineering GA HK383 UT WOS:A1991HK38300014 ER PT J AU HARTMAN, JA WHITT, JH AF HARTMAN, JA WHITT, JH TI R-AND-M TASK REQUIREMENTS FOR RESEARCH-AND-DEVELOPMENT PROGRAMS SO PROCEEDINGS ANNUAL RELIABILITY AND MAINTAINABILITY SYMPOSIUM LA English DT Article; Proceedings Paper CT 1991 ANNUAL SYMP ON RELIABILITY AND MAINTAINABILITY CY JAN 29-31, 1991 CL ORLANDO, FL SP IEEE, AMER SOC QUAL CONTROL, SOC RELIAB ENGINEERS, SOC LOGIST ENGINEERS, SYST SAFETY SOC, INST IND ENGINEERS DE R-AND-M TASKS; R-AND-M LESSONS LEARNED; R-AND-M PROGRAM; REVIEW; RESEARCH AND DEVELOPMENT AB This paper discusses the U.S. Army Strategic Defense Command (USASDC) approach to the definition and implementation of Reliability and Maintainability (R&M) programs for Research and Development (R&D) efforts. The method the Command employs to monitor and track R&M program implementation is described. Lessons learned from previous programs implemented at the Command are identified and their application is discussed. Presented are R&M task requirements for a typical R&D program. The applications of R&M planning, task requirements, and program reviews discussed in this report will assist in the development and implementation of an effective R&M program for R&D efforts. The application of lessons learned from field experiences are already producing effective results. RP HARTMAN, JA (reprint author), USA,STRATGG DEF COMMAND,POB 1500,HUNTSVILLE,AL 35807, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0149-144X J9 P ANNU REL MAINT SYM JI Proc. Annu. Reliab. Maintainab. Symp. PD JAN 29 PY 1991 IS SYM BP 161 EP 167 PG 7 WC Engineering, Multidisciplinary; Engineering, Industrial SC Engineering GA HK383 UT WOS:A1991HK38300026 ER PT J AU MARION, GM INTRONE, DS VANCLEVE, K AF MARION, GM INTRONE, DS VANCLEVE, K TI THE STABLE ISOTOPE GEOCHEMISTRY OF CACO3 ON THE TANANA RIVER FLOODPLAIN OF INTERIOR ALASKA, USA - COMPOSITION AND MECHANISMS OF FORMATION SO CHEMICAL GEOLOGY LA English DT Article ID PEDOGENIC CARBONATE; MOJAVE-DESERT; SOIL; PRECIPITATION; DISSOLUTION; CALIFORNIA; CHEMISTRY; DEPOSITS; CLIMATE; DIOXIDE AB On the river floodplains of interior Alaska, forests exist on calcareous, alluvial soils. The objectives of this study were to determine the stable C-13 and O-18 isotopic composition of CaCO3 along a plant primary successional sequence (250 yr.) and to examine possible mechanisms controlling the formation of CaCO3 in these floodplain soils. Soil samples were analyzed from duplicate plots of three successional stages: open shrub (Stage III, 4 yr. old), young balsam poplar-alder (Stage V, 30 yr. old), and mature white spruce (Stage VIII, 170-250 yr. old). The early stages of plant succession showed little variation in the mean soil delta-C-13-PDB (-4.3 to -4.0 parts per thousand), while the Stage-VIII sites showed the greatest carbon depletion (delta-C-13-PDB = -7.9 to -6.2 parts per thousand). The mean soil delta-O-18-PDB-values ranged from -16.3 to -14.6 parts per thousand. These low delta-O-18-values reflect, in part, the very depleted meteoric precipitation (delta-O-18-PDB = -50.3 parts per thousand) for this cold, continental site. A few surface "salt crust" samples showed significant enrichment in both C and O isotopes. Six calcite-bearing rock samples from the Alaska Range, the source of the alluvial parent material, fell into two classes with means for delta-C-13-PDB of -0.2 and -5.2 parts per thousand and means for delta-O-18-PDB of -14.6 and -18.7 parts per thousand, respectively. The early Stage-III profiles showed little variation in isotopic composition with soil depth, suggesting that the CaCO3 was primarily inherited with the alluvial material and was not formed in situ. Surface evaporation of water played a minor role and transpirational loss of water played a major role in altering the isotopic composition of soil CaCO3 along the successional sequence. There was no evidence supporting freezing as a mechanism controlling soil CaCO3 precipitation. Over the 170-250-yr.-old plant successional sequence, the biotic factor significantly altered the isotopic composition of soil CaCO3. C1 UNIV ALASKA,FOREST SOILS LAB,FAIRBANKS,AK 99775. SAN DIEGO STATE UNIV,DEPT BIOL,SAN DIEGO,CA 92182. RP MARION, GM (reprint author), USA,CORPS ENGINEERS,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 41 TC 24 Z9 29 U1 0 U2 2 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0009-2541 J9 CHEM GEOL JI Chem. Geol. PD JAN 25 PY 1991 VL 86 IS 2 BP 97 EP 110 DI 10.1016/0168-9622(91)90056-3 PG 14 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA EX319 UT WOS:A1991EX31900002 ER PT J AU WU, XD MUENCHAUSEN, RE NOGAR, NS PIQUE, A EDWARDS, R WILKENS, B RAVI, TS HWANG, DM CHEN, CY AF WU, XD MUENCHAUSEN, RE NOGAR, NS PIQUE, A EDWARDS, R WILKENS, B RAVI, TS HWANG, DM CHEN, CY TI EPITAXIAL YTTRIA-STABILIZED ZIRCONIA ON (1102)SAPPHIRE FOR YB2CU3O7-DELTA THIN-FILMS SO APPLIED PHYSICS LETTERS LA English DT Article ID SILICON; GROWTH; DEPOSITION AB Epitaxial yttria-stabilized zirconia (YSZ) films were deposited on (1102BAR1) sapphire by pulsed laser deposition. The films are formed in a cubic phase with the a axis normal to the substrate surface. Ion beam (2.8 MeV He++) channeling measurements shows that the YSZ films are highly crystalline with a channeling minimum yield of 8%. The epitaxial relationship between the film and substrate is further confirmed by a cross-section transmission electron microscopy study. Epitaxial YBa2Cu3O7-delta thin films deposited on YSZ/sapphire have T(c) and J(c) of up to 89 K and 1 x 10(6) A/cm2 at 77 K, respectively. C1 UNIV CALIF LOS ALAMOS SCI LAB,ERDC,DIV CHEM & LASER SCI,LOS ALAMOS,NM 87545. NEOCERA INC,NEW BRUNSWICK,NJ 08901. BELLCORE,RED BANK,NJ 07701. RP WU, XD (reprint author), UNIV CALIF LOS ALAMOS SCI LAB,ERDC,DIV MAT SCI & TECHNOL,LOS ALAMOS,NM 87545, USA. NR 17 TC 71 Z9 73 U1 0 U2 5 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD JAN 21 PY 1991 VL 58 IS 3 BP 304 EP 306 DI 10.1063/1.104669 PG 3 WC Physics, Applied SC Physics GA ET681 UT WOS:A1991ET68100033 ER PT J AU GILBERT, MD SCHNEIDER, NS MACKNIGHT, WJ AF GILBERT, MD SCHNEIDER, NS MACKNIGHT, WJ TI MECHANISM OF THE DICYANDIAMIDE EPOXIDE REACTION SO MACROMOLECULES LA English DT Article ID SYSTEMS; RESINS; CURE AB A mechanism is proposed for the dicyandiamide (dicy) cure of epoxy resins based on the analysis of products formed by the reaction of a monofunctional epoxide with dicy and with cyanamide. Products were isolated from the uncatalyzed reaction mixtures using preparatory liquid chromatography and were characterized by FTIR, NMR, mass spectrometry, and elemental analysis. Both linear dicy/epoxide adducts and cyclical species were identified and the mechanism of the cyclization reaction was delineated. A mechanism for carbonyl generation during the later stages of cure was also found. C1 UNIV MASSACHUSETTS,DEPT POLYMER SCI & ENGN,AMHERST,MA 01003. RP GILBERT, MD (reprint author), USA,MAT TECHNOL LAB,POLYMER RES BRANCH,WATERTOWN,MA 02172, USA. NR 14 TC 70 Z9 71 U1 4 U2 28 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0024-9297 J9 MACROMOLECULES JI Macromolecules PD JAN 21 PY 1991 VL 24 IS 2 BP 360 EP 369 DI 10.1021/ma00002a004 PG 10 WC Polymer Science SC Polymer Science GA EU814 UT WOS:A1991EU81400004 ER PT J AU SINGLER, RE WILLINGHAM, RA NOEL, C FRIEDRICH, C BOSIO, L ATKINS, E AF SINGLER, RE WILLINGHAM, RA NOEL, C FRIEDRICH, C BOSIO, L ATKINS, E TI THERMOTROPIC LIQUID-CRYSTALLINE POLY(ORGANOPHOSPHAZENE) SO MACROMOLECULES LA English DT Article ID X-RAY-DIFFRACTION; THERMAL TRANSITION BEHAVIOR; SIDE-CHAIN POLYMERS; PHASE-TRANSITIONS; PAIRED MESOGENS; POLY(DICHLOROPHOSPHAZENE); POLYSILOXANES; PHOSPHAZENES AB The liquid crystalline behavior of a poly(organophosphazene) with two 2-(((4-n-butylphenyl)-azo)phenoxy)ethoxy side chains per phosphorus atom has been investigated by differential scanning calorimetry, polarized optical microscopy, and X-ray diffraction. On cooling from the isotropic liquid (above 185-degrees-C) a viscous mesophase is first observed which shows the characteristic focal conic texture typical of low molar mass smectic A phases. As the temperature falls below 160-155-degrees-C, a smectic C-like mesophase appears. In these structures, pairs of side chains decorate the backbone at ca. 2.45-angstrom intervals, and this congestion can be relieved in the cis-trans (2(1) helix) conformation when the stacking periodicity becomes 4.9-angstrom. In the smectic phases it is likely that the backbone disorders sufficiently to allow the mesogenic side groups to stack and, aided by the flexible spacer, allow the creation of layers perpendicular to the stacking direction. In the smectic A phase, the layer thickness is ca. 25.5-angstrom, which implies a "bilayer" structure in which the side chains would overlap in an antiparallel interdigitated structure. The smectic A-smectic C transition involves expansion in the plane orthogonal to the polymer chains. The interpenetration of the side groups disappears but the side chains tilt down with respect to the normal to the layer planes to stack closer. Below 150-145-degrees-C the sample crystallizes and in the oriented form can be indexed on an orthorhombic unit cell with alpha = 35.7-angstrom. b = 17.85-angstrom, and c (fiber axis) = 9.85-angstrom. This doubling of the 4.9-angstrom chain repeat has been reported for other polyphosphazene structures and can arise from alternating perturbations of the side chains or a change in the backbone conformation. C1 LAB PHYSICOCHIM STRUCT & MACROMOLEC,F-75231 PARIS 05,FRANCE. UNIV BRISTOL,HH WILLS PHYS LAB,BRISTOL BS8 1TL,AVON,ENGLAND. LAB PHYS LIQUIDES & ELECTROCHIM,F-75231 PARIS 05,FRANCE. RP SINGLER, RE (reprint author), USA,MAT TECHNOL LAB,POLYMER RES BRANCH,WATERTOWN,MA 02172, USA. NR 37 TC 41 Z9 42 U1 0 U2 3 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0024-9297 J9 MACROMOLECULES JI Macromolecules PD JAN 21 PY 1991 VL 24 IS 2 BP 510 EP 516 DI 10.1021/ma00002a026 PG 7 WC Polymer Science SC Polymer Science GA EU814 UT WOS:A1991EU81400026 ER PT J AU HACKER, HD OHARA, M AF HACKER, HD OHARA, M TI FLOTATION DEVICES TO FACILITATE AMBLYOPIA THERAPY SO AMERICAN JOURNAL OF OPHTHALMOLOGY LA English DT Letter RP HACKER, HD (reprint author), BROOKE ARMY MED CTR,DEPT SURG,OPHTHALMOL SERV,FT SAM HOUSTON,TX 78234, USA. NR 2 TC 3 Z9 3 U1 0 U2 0 PU OPHTHALMIC PUBL CO PI CHICAGO PA 77 WEST WACKER DR, STE 660, CHICAGO, IL 60601 SN 0002-9394 J9 AM J OPHTHALMOL JI Am. J. Ophthalmol. PD JAN 15 PY 1991 VL 111 IS 1 BP 110 EP 111 PG 2 WC Ophthalmology SC Ophthalmology GA EQ346 UT WOS:A1991EQ34600024 PM 1985475 ER PT J AU WHITE, WL HOLLSTEN, DA AF WHITE, WL HOLLSTEN, DA TI A NEW INSTRUMENT FOR USE IN EVISCERATION SO AMERICAN JOURNAL OF OPHTHALMOLOGY LA English DT Letter C1 BROOKE ARMY MED CTR,DEPT SURG,OPHTHALMOL SERV,FT SAM HOUSTON,TX 78234. NR 2 TC 0 Z9 0 U1 0 U2 0 PU OPHTHALMIC PUBL CO PI CHICAGO PA 77 WEST WACKER DR, STE 660, CHICAGO, IL 60601 SN 0002-9394 J9 AM J OPHTHALMOL JI Am. J. Ophthalmol. PD JAN 15 PY 1991 VL 111 IS 1 BP 115 EP 116 PG 2 WC Ophthalmology SC Ophthalmology GA EQ346 UT WOS:A1991EQ34600028 PM 1985479 ER PT J AU MCLANE, GF MEYYAPPAN, M COLE, MW WRENN, C AF MCLANE, GF MEYYAPPAN, M COLE, MW WRENN, C TI MAGNETRON REACTIVE ION ETCHING OF GAAS - RESIDUAL DAMAGE STUDY SO JOURNAL OF APPLIED PHYSICS LA English DT Article AB Residual damage of GaAs samples etched in a magnetron reactive ion etcher has been studied. Aligned yields from ion channeling measurements show that the amount of dechanneling in the etched samples is virtually identical to that of an unetched control sample, which indicates low concentration of disorder. Transmission electron microscopy reveals that the surface morphology of etched samples is extremely good with defects in the form of small dislocation loops of 20-40 angstrom diam. It is shown that magnetron reactive ion etching is capable of yielding high etch rates with little surface damage. C1 SCI RES ASSOCIATES INC,POB 1058,GLASTONBURY,CT 06033. VITRON INC,EATONTOWN,NJ 07724. USA,ELECTR TECHNOL & DEVICES LAB,FT MONMOUTH,NJ 07703. NR 9 TC 13 Z9 13 U1 0 U2 0 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD JAN 15 PY 1991 VL 69 IS 2 BP 695 EP 697 DI 10.1063/1.347351 PG 3 WC Physics, Applied SC Physics GA EU225 UT WOS:A1991EU22500021 ER PT J AU NEIFELD, RA POTENZIANI, E SINCLAIR, WR HILL, WT TURNER, B PINKAS, A AF NEIFELD, RA POTENZIANI, E SINCLAIR, WR HILL, WT TURNER, B PINKAS, A TI PROPERTIES OF THE ABLATION PROCESS FOR EXCIMER LASER ABLATION OF Y1BA2CU3O7 SO JOURNAL OF APPLIED PHYSICS LA English DT Note ID THIN-FILMS; HIGH-TC AB The process of excimer laser ablation has been studied while varying the laser fluence from 0.237 to 19.1 J/cm2. Ion time-of-flight, total charge, target etch depth per pulse, and etch volume per pulse have been measured. Results indicate a maximum ablation volume and minimum ionization fraction occur near 5 J/cm2. Several of the parameters measured vary rapidly in the 1-5 J/cm2 range. Variation in these parameters strongly influences the properties of films grown by this technique. C1 MARTIN GOFFMAN ASSOCIATES,EDISON,NJ 08820. UNIV MARYLAND,INST PHYS SCI & TECHNOL,COLLEGE PK,MD 20742. RP NEIFELD, RA (reprint author), USA,ELECTR TECHNOL & DEVICES LAB,FT MONMOUTH,NJ 07703, USA. NR 11 TC 15 Z9 15 U1 0 U2 0 PU AMER INST PHYSICS PI MELVILLE PA CIRCULATION & FULFILLMENT DIV, 2 HUNTINGTON QUADRANGLE, STE 1 N O 1, MELVILLE, NY 11747-4501 USA SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD JAN 15 PY 1991 VL 69 IS 2 BP 1107 EP 1109 DI 10.1063/1.347380 PG 3 WC Physics, Applied SC Physics GA EU225 UT WOS:A1991EU22500092 ER PT J AU JENSEN, JO ADAMS, GF CHABALOWSKI, CF AF JENSEN, JO ADAMS, GF CHABALOWSKI, CF TI ABINITIO STUDY OF THE ELECTRONIC MAGNETIC CIRCULAR-DICHROISM SPECTRUM IN ACETYLENE - THE B[-X AND 1 1B2[-X TRANSITIONS SO JOURNAL OF CHEMICAL PHYSICS LA English DT Article ID UV SPECTRUM; EXCITED-STATES AB This study utilizes a newly implemented method based on first-order perturbation theory for calculating the electronic magnetic circular dichroism (MCD) spectra in molecules. As an initial application, the MCD band maxima have been calculated for the B approximately(1 1B(u))<--X approximately(1 1A(g)) and 1 1B2<--X approximately(1 1A1) electronic transitions in the trans and cis bent conformations (respectively) of acetylene. The band intensity is assumed to come entirely from the B0 term in the MCD equations of Stephens, which explicitly includes a first-order perturbation correction to the two electronic states involved in the transition. The wave functions are determined using ab initio quantum chemical techniques including state averaged CASSCF and multireference CI. There has been speculation that the 1 1B2<--X approximately band system might overlap the B approximately<--X approximately, and be part of the reason for the diffuse nature of the spectrum in the 185-170 nm region. This study considers this claim. The current calculations predict MCD band maxima for the 0-0 and 1-0 vibrational bands in the B approximately<--X approximately to be DELTA-epsilon(max)-0 = -3.48 and -5.82, respectively, while experiment gives -0.8 and -1.6. This is 10(3) times larger than the largest band maximum [DELTA-epsilon(max)-0(3-0) = -0.0037] calculated for the 1 1B2<--X approximately transition. This study also finds the absorption oscillator strengths for the B approximately<--X approximately to be a factor of 60 larger than that found in the 1 1B2<--X approximately. Thus while these results do predict both the B approximately<--X approximately and 1 1B2<--X approximately transitions to lie in the same spectral region, they do not support the hypothesis that the 1 1B2<--X approximately is a major contributor to either the absorption or MCD intensity in the 185-170 nm region. C1 USA,BALLIST RES LABS,SLCBR IB I,ABERDEEN PROVING GROUND,MD 21005. RP JENSEN, JO (reprint author), CHEM RES DEV & ENGN CTR,SMCCR RSP C,ABERDEEN PROVING GROUND,MD 21010, USA. NR 27 TC 2 Z9 2 U1 1 U2 2 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-9606 J9 J CHEM PHYS JI J. Chem. Phys. PD JAN 15 PY 1991 VL 94 IS 2 BP 1333 EP 1345 PG 13 WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical SC Chemistry; Physics GA EU592 UT WOS:A1991EU59200060 ER PT J AU HUMPHREY, M MOSCA, J BAKER, JR DRABICK, JJ CARR, FE BURKE, DS WARTOFSKY, L DJUH, YY BURMAN, KD AF HUMPHREY, M MOSCA, J BAKER, JR DRABICK, JJ CARR, FE BURKE, DS WARTOFSKY, L DJUH, YY BURMAN, KD TI ABSENCE OF RETROVIRAL SEQUENCES IN GRAVES-DISEASE SO LANCET LA English DT Note ID THYROID EPITHELIAL-CELLS; SARCOMA-VIRUS AB An earlier report of HIB-1 gene sequences in thyroid cell genomic DNA from patients with Graves' disease prompted use of the polymerase chain reaction technique to identify such sequences in Graves' disease thyroid tissue and in white blood-cells from these patients. We were unable to confirm the existence of HIV-1-related DNA sequences in Graves' specimens. C1 WALTER REED ARMY MED CTR,DEPT MED & CLIN INVEST,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DIV RETROVIROL DIS,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DIV BACTERIAL DIS,WASHINGTON,DC 20307. RP HUMPHREY, M (reprint author), WALTER REED ARMY MED CTR,KYLE METAB UNIT,ENDOCRINE METAB SERV,WASHINGTON,DC 20307, USA. OI /0000-0002-5704-8094 NR 9 TC 37 Z9 37 U1 0 U2 3 PU LANCET LTD PI LONDON PA 42 BEDFORD SQUARE, LONDON, ENGLAND WC1B 3SL SN 0140-6736 J9 LANCET JI Lancet PD JAN 5 PY 1991 VL 337 IS 8732 BP 17 EP 18 DI 10.1016/0140-6736(91)93335-7 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA EQ604 UT WOS:A1991EQ60400009 PM 1670652 ER PT J AU COHEN, MD MATHER, B AF COHEN, MD MATHER, B TI SULFATE ATTACK ON CONCRETE - RESEARCH NEEDS SO ACI MATERIALS JOURNAL LA English DT Article DE ACCELERATED TESTS; CEMENT PASTES; CONCRETES; DURABILITY; ETTRINGITE; FAILURE CRITERIA; GYPSUM; MAGNESIUM SULFATE; POZZOLANS; SODIUM SULFATE; SULFATE ATTACK; TRANSITION ZONE ID EXPANSIVE CEMENTS; SILICA FUME; SCHOOLS; THOUGHT; MORTARS AB The mechanism of sulfate attack on portland cement concrete is not well understood. This has limited the confidence that can be placed in and hence the reliability of existing standard tests and models to predict performance and service life of concrete subjected to sulfate attack. A systematic research effort on sulfate attack is necessary to establish five criteria. This would lead both to better understanding of the sulfate attack mechanism and to developing more reliable standard tests and better models to predict performance and service life. The objective of this paper is to present and discuss these five criteria. In addition, an approach for assessing the influence of pozzolans, or other cementing materials, on concrete performance and service life in sulfate environment is presented. C1 USA,ENGN WATERWAYS EXPT STN,STRUCT LAB,VICKSBURG,MS. RP COHEN, MD (reprint author), PURDUE UNIV,CIVIL ENGN,W LAFAYETTE,IN 47907, USA. NR 46 TC 103 Z9 108 U1 2 U2 16 PU AMER CONCRETE INST PI FARMINGTON HILLS PA 38800 INTERNATIONAL WAY, COUNTRY CLUB DRIVE, PO BOX 9094, FARMINGTON HILLS, MI 48333-9094 SN 0889-325X J9 ACI MATER J JI ACI Mater. J. PD JAN-FEB PY 1991 VL 88 IS 1 BP 62 EP 69 PG 8 WC Construction & Building Technology; Materials Science, Multidisciplinary SC Construction & Building Technology; Materials Science GA EX081 UT WOS:A1991EX08100009 ER PT J AU SHUELY, WJ INCE, BS AF SHUELY, WJ INCE, BS TI RHEOLOGICAL PROPERTIES OF HIGH-MOLECULAR-WEIGHT POLY[(METHYL METHACRYLATE)-CO-ETHYLACRYLATE-CO-BUTYLACRYLATE] SOLUTIONS - INFLUENCE OF POLYMER SOLVENT INTERACTIONS SO ACS SYMPOSIUM SERIES LA English DT Review ID SWELL AB The effects of polymer-solvent interactions on rheological viscoelastic properties is being investigated. Relatively small volume fractions, 0.02-0.06, of an ultra high molecular weight rheological processing aid, terpolymer poly(methylmethacrylate-co-ethylacrylate-co-butylacrylate), poly (MMA/EA/BA), form polymer solutions in the semidilute regime. Over 30 solutions were formulated to define several interaction categories. Polymer-solvent interactions were characterized by several methods: polymer cohesion phase diagram coordinates, limiting viscosity number, proton donating strength, and solubility with control homopolymers. Rheological measurements included steady shear first normal stress difference, apparent viscosity, hysteresis, transient, dynamic viscosity and storage and loss moduli. Relationships between degree or type of interaction and rheological properties have been formulated. RP SHUELY, WJ (reprint author), USA,SMCCR,RSC-P,ABERDEEN PROVING GROUND,MD 21010, USA. NR 12 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 SN 0097-6156 J9 ACS SYM SER PY 1991 VL 462 BP 286 EP 300 PG 15 WC Chemistry, Multidisciplinary SC Chemistry GA FR199 UT WOS:A1991FR19900017 ER PT J AU WHITBURN, KD DUNNE, CP AF WHITBURN, KD DUNNE, CP TI EVALUATION OF STABILIZERS FOR SYNTHETIC VESICLES AND MILK-FAT GLOBULES UNDER DRYING STRESS SO ACS SYMPOSIUM SERIES LA English DT Review ID LARGE UNILAMELLAR VESICLES; MEMBRANE; DIPALMITOYLPHOSPHATIDYLCHOLINE; DEHYDRATION; TREHALOSE; LIPOSOMES; FUSION AB Dipalmitoylphosphatidylcholine (DPPC) vesicles in aqueous buffer, prepared by sonication and controlled fusion, were characterized by differential scanning calorimetry (DSC) analysis. Size variations in vesicle preparations during fusion were analyzed by spectroturbidity measurements and laser scattering analysis. Inasmuch as the measured turbidity of a vesicle preparation was shown to be directly proportional to the concentration of the phospholipid in the vesicled form, the relative quantity of vesicles remaining after applying a drying and rehydration procedure was estimated from turbidity measurements taken before and after drying. A parameter, eta-R, the rehydration efficiency, was defined in terms of turbidity changes to express the resilience of vesicles to the drying-induced stress. Values of eta-R were determined for vesicles dried and rehydrated in the presence of candidate preservatives, including carbohydrates and metal ions. Disaccharides stabilized dried phospholipid vesicles better than monosaccharides; polyols were destabilizing at all studied concentrations, and metal ions were midly stabilizing only at low concentrations. Extracts of milk fat globules (MFG) from whole milk were analyzed for their resilience toward drying-induced rupture in the absence and presence of candidate preservatives by the spectroturbidimetric method. Of the studied additives, maltodextrin M-100 (a hydrolyzed corn starch) was found to be the most effective stabilizer. Analogous studies of dried diluted whole milk samples, in which the major contributor to sample turbidity was due to the component MFGs, indicated that the best single stabilizing additive toward drying-induced rupture of MFGs is maltodextrin M-100. C1 USA, NATICK RES & DEV LABS, CTR DEV ENGN, NATICK, MA 01760 USA. RP WHITBURN, KD (reprint author), FRAMINGHAM STATE COLL, DEPT CHEM & FOOD SCI, FRAMINGHAM, MA 01701 USA. NR 22 TC 0 Z9 0 U1 1 U2 1 PU AMER CHEMICAL SOC PI WASHINGTON PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN 0097-6156 J9 ACS SYM SER JI ACS Symp. Ser. PY 1991 VL 448 BP 161 EP 181 PG 21 WC Chemistry, Multidisciplinary SC Chemistry GA EV850 UT WOS:A1991EV85000013 ER PT J AU VELAGAPUDI, R HARTER, JG BRUECKNER, R PECK, CC AF VELAGAPUDI, R HARTER, JG BRUECKNER, R PECK, CC TI PHARMACOKINETIC PHARMACODYNAMIC MODELS IN ANALGESIC STUDY DESIGN SO ADVANCES IN PAIN RESEARCH AND THERAPY LA English DT Editorial Material C1 WALTER REED ARMY MED CTR,PILOT DRUG EVALUAT STAFF,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307. US FDA,CTR DRUG EVALUAT & RES,ROCKVILLE,MD 20857. RP VELAGAPUDI, R (reprint author), WALTER REED ARMY MED CTR,DIV BIOPHARMACEUT,WASHINGTON,DC 20307, USA. NR 2 TC 1 Z9 1 U1 0 U2 1 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0146-0722 J9 ADV PAIN RES THER JI Adv. Pain Res. Ther. PY 1991 VL 18 BP 559 EP 562 PG 4 WC Neurosciences SC Neurosciences & Neurology GA FD808 UT WOS:A1991FD80800039 ER PT J AU CARLON, HR GUELTA, MA GERBER, BV AF CARLON, HR GUELTA, MA GERBER, BV TI SOME CANDIDATE REPLACEMENT MATERIALS FOR DIOCTYL PHTHALATE IN HOT SMOKE AEROSOL PENETROMETER MACHINES SO AEROSOL SCIENCE AND TECHNOLOGY LA English DT Article AB For many decades dioctyl phthalate (DOP), a common industrial material, has been used by the U.S. Army and other agencies to simulate aerosol behavior in nondestructive gas mask and filter serviceability testing, and for related test purposes. Techniques are completely standardized. But DOP is now considered to be a potentially hazardous material. The research reported here, which was performed using ATI Q-127 and TDA-100 "hot smoke" aerosol penetrometer test machines, identified relatively innocuous, inexpensive replacement materials for DOP. One of these, a synthetic hydrocarbon (poly-alpha olefin [PAO]), can be used to replace DOP directly with minimum impact upon existing hardware and procedures. Of more than two dozen candidate replacement materials that were tested, isostearic acid and oleic acid also performed well as DOP replacements. All three materials also show promise for cold smoke testing applications. C1 OPTIMETRICS INC,ANN ARBOR,MI 48105. RP CARLON, HR (reprint author), USA,CTR CHEM RES DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010, USA. NR 13 TC 4 Z9 4 U1 1 U2 1 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0278-6826 J9 AEROSOL SCI TECH JI Aerosol Sci. Technol. PY 1991 VL 14 IS 2 BP 233 EP 246 DI 10.1080/02786829108959486 PG 14 WC Engineering, Chemical; Engineering, Mechanical; Environmental Sciences; Meteorology & Atmospheric Sciences SC Engineering; Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA EY671 UT WOS:A1991EY67100008 ER PT J AU SUTHERLAND, RA KHANNA, RK AF SUTHERLAND, RA KHANNA, RK TI OPTICAL-PROPERTIES OF ORGANIC-BASED AEROSOLS PRODUCED BY BURNING VEGETATION SO AEROSOL SCIENCE AND TECHNOLOGY LA English DT Article ID RESIDENTIAL WOOD SMOKE; PARTICLES; CONSTANTS; CARBON; FIRES; COMBUSTION; POTASSIUM; REGION; AREA; SIZE AB The real and imaginary refractive indexes of organic-based nonvolatile aerosols produced by burning vegetation are reported for the infrared spectral region. The data were obtained by an iterative Kramers-Kronig analysis of the transmission spectra (2-25-mu-m) obtained from thin-film samples deposited on a KBr substrate immersed directly in the smoke plumes of small-scale test fires. The results include samples from fires fueled by lawn grass, alfalfa, mesquite, tumbleweed, pine needles, and mixed twigs, leaves, and weeds. The most significant characteristics of all spectra are as follows: (a) strong absorptions in the 3-5-mu-m region owing to condensed water and CH3/CH2 groups of aliphatic hydrocarbons; (b) characteristic peaks in the 6-, 8-, and 10-mu-m regions owing to skeletal modes of aromatic and terpenic groups; and (c) relatively little absorption in the 10-12-mu-m region. The imaginary refractive index of all samples is comparable (approximately 0.10-0.30) in the 3-5- and 8-10-mu-m regions and is 3-10 times lower in the 10-12-mu-m region. In the 3-5-mu-m region, most of the absorption takes place in the interval between 3 and 4-mu-m as opposed to the 4-5-mu-m interval which shows significantly less absorption. It is also noteworthy that there is insignificant absorption in the 2.0-2.5-mu-m window region. Results are significantly different from values for elemental carbon which are known to be relatively wavelength independent in these spectral regions and of magnitude between approximately 0.50 and 1.0 for the imaginary index. Theoretical calculations, assuming particle sizes in the Rayleigh scattering regime, yields a mass extinction coefficient (m2/g) for the organic smokes on the order of approximately 0.20 for the 8-10-mu-m region and as high as 0.40 at 3-mu-m to near zero at 5-mu-m in the 3-5-mu-m window. C1 UNIV MARYLAND,DEPT CHEM & BIOCHEM,COLLEGE PK,MD 20742. RP SUTHERLAND, RA (reprint author), USA,ATMOSPHER SCI LAB,DIV ATMOSPHER RES,WHITE SANDS MISSILE RANGE,NM 88002, USA. NR 30 TC 23 Z9 24 U1 0 U2 6 PU ELSEVIER SCIENCE INC PI NEW YORK PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 SN 0278-6826 J9 AEROSOL SCI TECH JI Aerosol Sci. Technol. PY 1991 VL 14 IS 3 BP 331 EP 342 DI 10.1080/02786829108959495 PG 12 WC Engineering, Chemical; Engineering, Mechanical; Environmental Sciences; Meteorology & Atmospheric Sciences SC Engineering; Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA FE759 UT WOS:A1991FE75900005 ER PT J AU MEYERHOFF, JL MOUGEY, EH MOORE, TO FERRIS, CF HUHMAN, KL AF MEYERHOFF, JL MOUGEY, EH MOORE, TO FERRIS, CF HUHMAN, KL TI PITUITARY, ADRENOCORTICAL, AND GONADAL RESPONSES TO ACUTE AND REPEATED AGONISTIC ENCOUNTERS IN MALE GOLD HAMSTERS SO AGGRESSIVE BEHAVIOR LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. UNIV MASSACHUSETTS,SCH MED,WORCESTER,MA 01605. NR 0 TC 0 Z9 0 U1 1 U2 1 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0096-140X J9 AGGRESSIVE BEHAV JI Aggressive Behav. PY 1991 VL 17 IS 2 BP 85 EP 86 PG 2 WC Behavioral Sciences; Psychology, Multidisciplinary SC Behavioral Sciences; Psychology GA FA659 UT WOS:A1991FA65900038 ER PT J AU HUHMAN, KL MOORE, TO MEYERHOFF, JL AF HUHMAN, KL MOORE, TO MEYERHOFF, JL TI BEHAVIORAL CONSEQUENCES OF REPEATED EXPOSURE TO DEFEAT IN MALE GOLDEN-HAMSTERS SO AGGRESSIVE BEHAVIOR LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0096-140X J9 AGGRESSIVE BEHAV JI Aggressive Behav. PY 1991 VL 17 IS 2 BP 106 EP 107 PG 2 WC Behavioral Sciences; Psychology, Multidisciplinary SC Behavioral Sciences; Psychology GA FA659 UT WOS:A1991FA65900065 ER PT J AU GAITHER, NS HULL, RW WORTHAM, DC YOST, WJ JELINEK, J AF GAITHER, NS HULL, RW WORTHAM, DC YOST, WJ JELINEK, J TI PULMONARY VENOUS OBSTRUCTION - UTILITY OF TRANSESOPHAGEAL ECHOCARDIOGRAPHY SO AMERICAN HEART JOURNAL LA English DT Note ID DISEASE C1 WALTER REED ARMY MED CTR,DEPT RADIOL,WASHINGTON,DC 20307. RP GAITHER, NS (reprint author), WALTER REED ARMY MED CTR,DEPT MED,CARDIOL SERV,WASHINGTON,DC 20307, USA. NR 7 TC 7 Z9 8 U1 0 U2 0 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0002-8703 J9 AM HEART J JI Am. Heart J. PD JAN PY 1991 VL 121 IS 1 BP 203 EP 205 DI 10.1016/0002-8703(91)90978-Q PN 1 PG 3 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA EQ993 UT WOS:A1991EQ99300031 PM 1985366 ER PT J AU RYALS, BD AF RYALS, BD TI MAJOR CONGENITAL NEUROLOGIC MALFORMATIONS SO AMERICAN JOURNAL OF DISEASES OF CHILDREN LA English DT Letter RP RYALS, BD (reprint author), WALTER REED ARMY MED CTR,DEPT CHILD NEUROL,WASHINGTON,DC 20307, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0002-922X J9 AM J DIS CHILD JI Am. J. Dis. Child. PD JAN PY 1991 VL 145 IS 1 BP 30 EP 30 PG 1 WC Pediatrics SC Pediatrics GA ER340 UT WOS:A1991ER34000005 PM 1985425 ER PT J AU WISWELL, TE AF WISWELL, TE TI MAJOR CONGENITAL NEUROLOGIC MALFORMATIONS - REPLY SO AMERICAN JOURNAL OF DISEASES OF CHILDREN LA English DT Letter RP WISWELL, TE (reprint author), WALTER REED ARMY MED CTR,DEPT PEDIAT,NEONATOL SERV,WASHINGTON,DC 20307, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0002-922X J9 AM J DIS CHILD JI Am. J. Dis. Child. PD JAN PY 1991 VL 145 IS 1 BP 30 EP 30 PG 1 WC Pediatrics SC Pediatrics GA ER340 UT WOS:A1991ER34000006 ER PT J AU RUFF, ME SOUTHGATE, WM WOOD, BP AF RUFF, ME SOUTHGATE, WM WOOD, BP TI RADIOLOGICAL CASE OF THE MONTH - NEONATAL APPENDICITIS WITH PERFORATION SO AMERICAN JOURNAL OF DISEASES OF CHILDREN LA English DT Note C1 TRIPLER ARMY MED CTR,DEPT PEDIAT,HONOLULU,HI 96859. NR 11 TC 10 Z9 10 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0002-922X J9 AM J DIS CHILD JI Am. J. Dis. Child. PD JAN PY 1991 VL 145 IS 1 BP 111 EP 112 PG 2 WC Pediatrics SC Pediatrics GA ER340 UT WOS:A1991ER34000026 PM 1985420 ER PT J AU MEADE, P MCDONNELL, B FELLOWS, D HOLTZMULLER, KC RUNKE, L AF MEADE, P MCDONNELL, B FELLOWS, D HOLTZMULLER, KC RUNKE, L TI ENTEROLITHS CAUSING INTERMITTENT OBSTRUCTION IN A PATIENT WITH CROHNS-DISEASE SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Article AB Calcified enteroliths as a cause of intermittent small bowel obstruction is an uncommon clinical entity. The pathophysiological mechanism involves stasis of intestinal contents and has been associated with Meckel's diverticulum, tuberculosis, and regional enteritis. This case describes prophylactic operative intervention in a symptomatic patient with enteroliths as a result of Crohn's disease. C1 TRIPLER ARMY MED CTR,GASTROENTEROL SERV,TRIPLER AMC,HI 96859. RP MEADE, P (reprint author), TRIPLER ARMY MED CTR,GEN SURG SERV,TRIPLER AMC,HI 96859, USA. NR 17 TC 3 Z9 4 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0002-9270 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD JAN PY 1991 VL 86 IS 1 BP 96 EP 98 PG 3 WC Gastroenterology & Hepatology SC Gastroenterology & Hepatology GA EU732 UT WOS:A1991EU73200021 PM 1986562 ER PT J AU MICOZZI, MS OLEARY, CA AF MICOZZI, MS OLEARY, CA TI SURVIVING FIELDWORK - A REPORT OF THE ADVISORY PANEL ON HEALTH AND SAFETY IN FIELDWORK - HOWELL,N SO AMERICAN JOURNAL OF HUMAN BIOLOGY LA English DT Book Review C1 UNIV PENN,DEPT ANTHROPOL,PHILADELPHIA,PA 19104. RP MICOZZI, MS (reprint author), WALTER REED ARMY MED CTR,ARMED FORCES INST PATHOL,NATL MUSEUM HLTH & MED,WASHINGTON,DC 20307, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 1042-0533 J9 AM J HUM BIOL JI Am. J. Hum. Biol. PY 1991 VL 3 IS 4 BP 405 EP 406 DI 10.1002/ajhb.1310030411 PG 2 WC Anthropology; Biology SC Anthropology; Life Sciences & Biomedicine - Other Topics GA GB903 UT WOS:A1991GB90300010 ER PT J AU CHARNEY, DI GOUGE, SF AF CHARNEY, DI GOUGE, SF TI CHEMICAL PERITONITIS SECONDARY TO INTRAPERITONEAL VANCOMYCIN SO AMERICAN JOURNAL OF KIDNEY DISEASES LA English DT Article DE PERITONEAL DIALYSIS; CHEMICAL PERITONITIS; VANCOMYCIN RP CHARNEY, DI (reprint author), BROOKE ARMY MED CTR,DEPT MED NEPHROL SERV,SAN ANTONIO,TX 78234, USA. NR 6 TC 21 Z9 21 U1 1 U2 1 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0272-6386 J9 AM J KIDNEY DIS JI Am. J. Kidney Dis. PD JAN PY 1991 VL 17 IS 1 BP 76 EP 79 PG 4 WC Urology & Nephrology SC Urology & Nephrology GA ER339 UT WOS:A1991ER33900014 PM 1986571 ER PT J AU GLASS, AR AF GLASS, AR TI USE OF BETA-BLOCKERS IN THYROTOXIC PATIENTS WITH HEART-FAILURE SO AMERICAN JOURNAL OF MEDICINE LA English DT Letter RP GLASS, AR (reprint author), WALTER REED ARMY MED CTR,WASHINGTON,DC 20307, USA. NR 4 TC 0 Z9 0 U1 0 U2 1 PU EXCERPTA MEDICA INC PI NEW YORK PA 245 WEST 17TH STREET, NEW YORK, NY 10011 SN 0002-9343 J9 AM J MED JI Am. J. Med. PD JAN PY 1991 VL 90 IS 1 BP 136 EP 137 DI 10.1016/0002-9343(91)90527-5 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA ET987 UT WOS:A1991ET98700030 PM 1670906 ER PT J AU LABBATE, LA SHEARER, G WALDREP, DA AF LABBATE, LA SHEARER, G WALDREP, DA TI A CASE OF RECURRENT PREMENSTRUAL PSYCHOSIS SO AMERICAN JOURNAL OF PSYCHIATRY LA English DT Letter ID EPILEPSY C1 TRIPLER ARMY MED CTR,HONOLULU,HI 96859. NR 5 TC 5 Z9 5 U1 0 U2 0 PU AMER PSYCHIATRIC ASSOCIATION PI WASHINGTON PA 1400 K ST NW, WASHINGTON, DC 20005 SN 0002-953X J9 AM J PSYCHIAT JI Am. J. Psychiat. PD JAN PY 1991 VL 148 IS 1 BP 147 EP 147 PG 1 WC Psychiatry SC Psychiatry GA EQ124 UT WOS:A1991EQ12400051 PM 1984698 ER PT J AU KNAPIK, JJ BAUMAN, CL JONES, BH HARRIS, JM VAUGHAN, L AF KNAPIK, JJ BAUMAN, CL JONES, BH HARRIS, JM VAUGHAN, L TI PRESEASON STRENGTH AND FLEXIBILITY IMBALANCES ASSOCIATED WITH ATHLETIC INJURIES IN FEMALE COLLEGIATE ATHLETES SO AMERICAN JOURNAL OF SPORTS MEDICINE LA English DT Article AB One hundred thirty-eight female collegiate athletes, participating in eight weightbearing varsity sports, were administered preseason strength and flexibility tests and followed for injuries during their sports seasons. Strength was measured as the maximal isokinetic torque of the right and left knee flexors and knee extensors at 30 and 180 deg/sec. Flexibility was measured as the active range of motion of several lower body joints. An athletic trainer evaluated and recorded injuries occurring to the athletes in practice or competition. Forty percent of the women suffered one or more injuries. Athletes experienced more lower extremity injuries if they had: 1) a right knee flexor 15% stronger than the left knee flexor at 180 deg/sec; 2) a right hip extensor 15% more flexible than the left hip extensor; 3) a knee flexor/knee extensor ratio of less than 0.75 at 180 deg/sec. There was a trend for higher injury rates to be associated with knee flexor or hip extensor imbalances of 15% or more on either side of the body. These data demonstrate that specific strength and flexibility imbalances are associated with lower extremity injuries in female collegiate athletes. RP KNAPIK, JJ (reprint author), USA,ENVIRONM MED RES INST,NATICK,MA 01760, USA. NR 0 TC 280 Z9 288 U1 2 U2 48 PU AMER ORTHOPAEDIC SOC SPORT MED PI WALTHAM PA 230 CALVARY STREET, WALTHAM, MA 02154 SN 0363-5465 J9 AM J SPORT MED JI Am. J. Sports Med. PD JAN-FEB PY 1991 VL 19 IS 1 BP 76 EP 81 DI 10.1177/036354659101900113 PG 6 WC Orthopedics; Sport Sciences SC Orthopedics; Sport Sciences GA EV643 UT WOS:A1991EV64300013 PM 2008935 ER PT J AU WONGSRICHANALAI, C PORNSILAPATIP, J NAMSIRIPONGPUN, V WEBSTER, HK LUCCINI, A PANSAMDANG, P WILDE, H PRASITTISUK, M AF WONGSRICHANALAI, C PORNSILAPATIP, J NAMSIRIPONGPUN, V WEBSTER, HK LUCCINI, A PANSAMDANG, P WILDE, H PRASITTISUK, M TI ACRIDINE-ORANGE FLUORESCENT MICROSCOPY AND THE DETECTION OF MALARIA IN POPULATIONS WITH LOW-DENSITY PARASITEMIA SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID CENTRIFUGED PARASITES; RAPID DIAGNOSIS; HEMATOPARASITES AB Detection of low-density malaria parasites with Giemsa-stained thick smears (G-TS) requires time and experience and becomes impractical with high sample loads. Acridine orange fluorescent microscopy (AO/FM) of capillary centrifuged blood may offer an alternative technique. We compared AO/FM readings with G-TS in 290 specimens from asymptomatic people in Thai villages endemic for malaria. AO/FM specimens were prepared in modified capillary tubes coated with acridine orange (Quantitative Buffy Coat or "QBC tubes") and examined under a fluorescent microscope. Twenty-three (85.2%) of the 27 specimens found positive by G-TS had under 100 parasites/mu-l blood (< 35 parasites/200 microscopic fields). The overall AO/FM sensitivity was 78.9% [range: 66.7% (10/15) - 86.7% (13/15)]. For Plasmodium falciparum, regardless of stages, the sensitivities varied from 66.7% (8/12) to 91.7% (11/12). AO/FM performed better for P. falciparum than for Plasmodium vivax and for asexual than for sexual stages of the parasite. However, the species- and stage-specific results must be interpreted with caution because of the small sample sizes and very low parasite densities involved. The test specificity was 96.6% [range: 95.6% (263/275) - 97.1% (263/271)]. These levels of accuracy plus the known advantages of AO/FM suggest that the test, supplemented with G-TS to improve species and stage differentiation, is also useful for screening low-density parasitemias. C1 THAI RED CROSS SOC,QUEEN SAOVABNA MEM INST,BANGKOK,THAILAND. PRA POKKLAO PROVINCIAL HOSP,CHANTHABURI,THAILAND. MINIST PUBL HLTH,DIV MALARIA,BANGKOK,THAILAND. PROGRAM APPROPRIATE TECHNOL HLTH DIATECH,BANGKOK,THAILAND. RP WONGSRICHANALAI, C (reprint author), ARMED FORCES RES INST MED SCI,DEPT IMMUNOL & BIOCHEM,315-6 RAJVITHI RD,BANGKOK 10400,THAILAND. NR 6 TC 33 Z9 33 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JAN PY 1991 VL 44 IS 1 BP 17 EP 20 PG 4 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA EY659 UT WOS:A1991EY65900003 PM 1996735 ER PT J AU BROWN, AE WEBSTER, HK KRINCHAI, K GORDON, DM WIRTZ, RA PERMPANICH, B AF BROWN, AE WEBSTER, HK KRINCHAI, K GORDON, DM WIRTZ, RA PERMPANICH, B TI CHARACTERISTICS OF NATURAL ANTIBODY-RESPONSES TO THE CIRCUMSPOROZOITE PROTEIN OF PLASMODIUM-VIVAX SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE LA English DT Article ID FALCIPARUM-MALARIA; IMMUNODOMINANT EPITOPE; SPOROZOITE; PARASITES; INFECTION AB The antibody response to the prototype circumsporozoite (CS) protein of Plasmodium vivax (CSPV) was studied in Thai soldiers experiencing occupational malaria. Seventy-four (65%) of 114 men followed during assignment to a malaria transmission area developed blood-stage infection with P. vivax. IgG antibodies against the central repeat region of the CSPV protein were quantitated by ELISA using the recombinant protein, NS1(81) V20, as the capture antigen. One quarter of the subjects had detectable anti-CSPV antibodies at the beginning of the study. CSPV antibody seroconversion was documented in 16 of 26 subjects assessed during their first observed episodes of vivax malaria. This antibody response was of moderate magnitude, fell off after the first week post-diagnosis and appeared, at the low levels observed, to be unassociated with protection. Continued assessment of anti-CSPV antibody after subjects left the transmission area found no increase associated with relapse of P. vivax. These findings indicate that CS antibody responses to P. vivax during occupational malaria share many characteristics with responses to P. falciparum. C1 WALTER REED ARMY MED CTR,DEPT IMMUNOL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT ENTOMOL,WASHINGTON,DC 20307. RP BROWN, AE (reprint author), ARMED FORCES RES INST MED SCI,BANGKOK,THAILAND. NR 23 TC 15 Z9 15 U1 0 U2 0 PU AMER SOC TROP MED & HYGIENE PI MCLEAN PA 8000 WESTPARK DRIVE SUITE 130, MCLEAN, VA 22101 SN 0002-9637 J9 AM J TROP MED HYG JI Am. J. Trop. Med. Hyg. PD JAN PY 1991 VL 44 IS 1 BP 21 EP 27 PG 7 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA EY659 UT WOS:A1991EY65900004 PM 1996736 ER PT J AU MORSE, BC CHUANG, AH RUNNER, RR MCPHERSON, JC MCPHERSON, JC AF MORSE, BC CHUANG, AH RUNNER, RR MCPHERSON, JC MCPHERSON, JC TI THERMAL-SHOCK [COLD SHOCK] OF RED-BLOOD-CELLS FROM MINIPIGS, RATS AND OLD BANK BLOOD SO AMERICAN ZOOLOGIST LA English DT Meeting Abstract C1 EISENHOWER ARMY MED CTR,DEPT CLIN INVEST,FT GORDON,GA. MED COLL GEORGIA,AUGUSTA,GA 30912. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC ZOOLOGISTS PI LAWRENCE PA 1041 NEW HAMPSHIRE ST, LAWRENCE, KS 66044 SN 0003-1569 J9 AM ZOOL JI Am. Zool. PY 1991 VL 31 IS 5 BP A77 EP A77 PG 1 WC Zoology SC Zoology GA GV285 UT WOS:A1991GV28500303 ER PT J AU NOVAK, TJ QUINNDOGGETT, K AF NOVAK, TJ QUINNDOGGETT, K TI 2-(DIPHENYLACETYL)-1,3-INDANEDIONE-1-HYDRAZONE (DIPAIN) DERIVATIVES FOR DETECTION OF TRICHOTHECENE MYCOTOXINS SO ANALYTICAL LETTERS LA English DT Article DE DIRECT TEST; SENSOR COATINGS; FLUORESCENCE; 2-(DIPHENYLACETYL)-1,3-INDANEDIONE-1-HYDRAZONE DERIVATIVES; CELLULOSE; T-2 TOXIN; HT-2 DIACETOXYSCIRPENOL; NEOSOLANIOL; FUSARENON-X AB 2-(Diphenylacetyl)-1,3-indanedione-1-hydrazone and its derivatives where the NH2 has been replaced by a substituted NH or an imino group give fluorescence enhancement with trichothecene mycotoxins. Absolute amounts of T-2 toxin as low as 50 ng are detectable. Detection limits for HT-2, Diacetoxyscirpenol, Neosolaniol, and Fusarenon-X range from 0.1 to 4-mu-g. The advantage in using 2-(diphenylacetyl)-1,3-indanedione-1-hydrazone (DIPAIN) derivatives for the detection of trichothecene mycotoxins is that response time is based on the rate of formation of a molecular association complex between the toxin and the detector reagent rather than on the chemical reactivity of the toxin. Hence, sensitive detection or mycotoxins can be achieved simply and rapidly at 25-degrees-C. Since DIPAIN derivatives have been found to be direct-acting reagents capable of detecting droplets of dissolved trichothecenes, it is speculated that they may be useful as coatings in optical waveguide devices or in other devices that are developed as field detectors for aerosols that contain trichothecene mycotoxins. The DIPAIN reagents may also be used in kits that are designed to detect surface contamination by trichothecene mycotoxins. RP NOVAK, TJ (reprint author), USA,CTR DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010, USA. NR 8 TC 2 Z9 2 U1 1 U2 4 PU MARCEL DEKKER INC PI NEW YORK PA 270 MADISON AVE, NEW YORK, NY 10016 SN 0003-2719 J9 ANAL LETT JI Anal. Lett. PY 1991 VL 24 IS 6 BP 913 EP 924 PG 12 WC Chemistry, Analytical SC Chemistry GA FW299 UT WOS:A1991FW29900002 ER PT J AU NOVAK, TJ HENDERSON, VD PARSONS, JA AF NOVAK, TJ HENDERSON, VD PARSONS, JA TI 4,4'-BIS(DIMETHYLAMINO)THIOBENZOPHENONE AS A 2-CHLOROETHYLETHYLSULFIDE VAPOR-SENSING COATING FOR OPTICAL BASED MICROSENSORS SO ANALYTICAL LETTERS LA English DT Article DE 4,4'-BIS(DIMETHYLAMINO)THIOBENZOPHENONE; 2-CHLOROETHYLETHYLSULFIDE; MICROSENSOR COATING; ALUMINA; CHROMOGENIC VAPOR DETECTION AB The chromogenic detector reagent, 4,4'-bis(dimethylamino)thiobenzophenone (TMK), has been studied as a solid-state coating for sensing 2-chloroethylethylsulfide (CEES) vapor. The type of solid reaction support is a critical factor affecting both the stability and performance of the coating; alumina is the preferred support. When monitored with a fiber-optic spectrophotometer, the TMK coating on an alumina support was found capable of detecting CEES at concentrations down to the low ppm level. Unstabilized TMK coatings were found to be highly susceptible to photodegradation. Photostability was improved significantly by including 2,6-di-tert-butylphenol in the coating formulation. C1 GEO CENTERS INC,FT WASHINGTON,MD 20744. RP NOVAK, TJ (reprint author), USA,CTR DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010, USA. NR 4 TC 3 Z9 3 U1 0 U2 0 PU MARCEL DEKKER INC PI NEW YORK PA 270 MADISON AVE, NEW YORK, NY 10016 SN 0003-2719 J9 ANAL LETT JI Anal. Lett. PY 1991 VL 24 IS 6 BP 925 EP 934 PG 10 WC Chemistry, Analytical SC Chemistry GA FW299 UT WOS:A1991FW29900003 ER PT J AU DOWLING, JP SCHLEICH, WP WHEELER, JA AF DOWLING, JP SCHLEICH, WP WHEELER, JA TI INTERFERENCE IN PHASE-SPACE SO ANNALEN DER PHYSIK LA English DT Review ID SQUEEZED STATES; CORRESPONDENCE PRINCIPLE; PHOTON DISTRIBUTION; NUMBER STATES; OSCILLATIONS; MECHANICS; PHYSICS; APPROXIMATIONS; LIGHT AB A central problem in quantum mechanics is the calculation of the overlap, that is, the scalar product between two quantum states. In the semiclassical limit (Bohr's correspondence principle) we visualize tb is quantity as the area of overlap between two bands in phase space. In the case of more than one overlap the contributing amplitudes have to be combined with a phase difference again determined by an area in phase space. In this sense the familiar double-slit interference experiment is generalized to an interference in phase space. We derive this concept by the WKB approximation, illustrate it by the example of Franck-Condon transitions in diatomic molecules, and compare it with and contrast it to Wigner's concept of pseudo-probabilities in phase space. C1 PRINCETON UNIV,DEPT PHYS,PRINCETON,NJ 08544. MAX PLANCK INST QUANTUM OPT,W-8046 GARCHING,GERMANY. RP DOWLING, JP (reprint author), USA,MISSILE COMMAND,AMSMI RD WS,REDSTONE ARSENAL,AL 35898, USA. RI DOWLING, JONATHAN/L-2749-2013 NR 111 TC 42 Z9 42 U1 0 U2 2 PU JOHANN AMBROSIUS BARTH VERLAG PI HEIDELBERG PA IM WEIHER 10, D-69121 HEIDELBERG, GERMANY SN 0003-3804 J9 ANN PHYS-LEIPZIG JI Ann. Phys.-Leip. PY 1991 VL 48 IS 7 BP 423 EP 478 PG 56 WC Physics, Multidisciplinary SC Physics GA GU633 UT WOS:A1991GU63300001 ER PT J AU LAVEN, RD SHAW, RB DOUGLAS, PP DIERSING, VE AF LAVEN, RD SHAW, RB DOUGLAS, PP DIERSING, VE TI POPULATION-STRUCTURE OF THE RECENTLY REDISCOVERED HAWAIIAN SHRUB TETRAMOLOPIUM-ARENARIUM (ASTERACEAE) SO ANNALS OF THE MISSOURI BOTANICAL GARDEN LA English DT Article AB A demographic monitoring study was initiated in the sole known population of Tetramolopium arenarium, a taxon that was considered extinct until recently rediscovered on the Pohakuloa Training Area, Island of Hawaii, Hawaii. Spatial distribution, size structures, fife history stage structure and reproductive output were determined for the population. This sole population is restricted to a 100 m by 300 m area along a mesic ridge system and is comprised of 134 individuals. Size class frequency distributions are bell-shaped with the population dominated by large individuals. In spite of large flower and seed production, interpretation of these distributions reveals that this species is either on the verge of extinction or that episodic establishment is necessary to ensure the long-term persistence of this rare taxon. In order to safeguard this species, we recommend that military operations and hunting activity be restricted and that the area be fenced to exclude feral animals. C1 COLORADO STATE UNIV,DEPT RANGE SCI,FT COLLINS,CO 80523. USA,CORPS ENGINEERS,CTR ENGN & HOUSING SUPPORT CEHSC FN,FT BELVOIR,VA 22060. RP LAVEN, RD (reprint author), COLORADO STATE UNIV,DEPT FOREST SCI,FT COLLINS,CO 80523, USA. NR 14 TC 2 Z9 3 U1 1 U2 2 PU MISSOURI BOTANICAL GARDEN PI ST LOUIS PA 2345 TOWER GROVE AVENUE, ST LOUIS, MO 63110 SN 0026-6493 J9 ANN MO BOT GARD JI Ann. Mo. Bot. Gard. PY 1991 VL 78 IS 4 BP 1073 EP 1080 DI 10.2307/2399744 PG 8 WC Plant Sciences SC Plant Sciences GA GQ641 UT WOS:A1991GQ64100013 ER PT J AU WARTOFSKY, L AF WARTOFSKY, L TI USE OF SENSITIVE TSH ASSAY TO DETERMINE OPTIMAL THYROID-HORMONE THERAPY AND AVOID OSTEOPOROSIS SO ANNUAL REVIEW OF MEDICINE LA English DT Review DE THYROTROPIN; HYPERTHYROIDISM; BONE MINERAL ID L-THYROXINE; SUBCLINICAL HYPERTHYROIDISM; BONE-DENSITY; THYROTROPIN; LEVOTHYROXINE AB Reported deleterious effects of thyroid hormone on bone mineral density have alarmed clinicians and patients alike because of the potential risks of osteoporosis and fracture. The known adverse effects of excessive thyroid hormones on bone are briefly reviewed, with distinction made between the status and potential consequences of replacement versus suppressive therapy. Employing the newer ultrasensitive TSH assay, management guidelines are offered to the clinician that should minimize risks of osteopenia in patients taking thyroid hormone. C1 UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. RP WARTOFSKY, L (reprint author), WALTER REED ARMY MED CTR,ENDOCRINE METAB SERV,WASHINGTON,DC 20307, USA. NR 16 TC 24 Z9 24 U1 0 U2 1 PU ANNUAL REVIEWS INC PI PALO ALTO PA 4139 EL CAMINO WAY, PO BOX 10139, PALO ALTO, CA 94303-0139 SN 0066-4219 J9 ANNU REV MED JI Annu. Rev. Med. PY 1991 VL 42 BP 341 EP 345 DI 10.1146/annurev.med.42.1.341 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA FE086 UT WOS:A1991FE08600033 PM 2035978 ER PT J AU MORREY, JD WARREN, RP OKLEBERRY, KM BURGER, RA CHIRIGOS, MA SIDWELL, RW AF MORREY, JD WARREN, RP OKLEBERRY, KM BURGER, RA CHIRIGOS, MA SIDWELL, RW TI EFFECT OF IMEXON TREATMENT ON FRIEND-VIRUS COMPLEX INFECTION USING GENETICALLY DEFINED MICE AS A MODEL FOR HIV-1 INFECTION SO ANTIVIRAL RESEARCH LA English DT Article DE IMEXON; AIDS; HIV-1; FRIEND VIRUS; MODEL; GENETICALLY ID MURINE LEUKEMIA VIRUSES; CELLS AB Imexon (4-imino-1,4-diazobicyclo-3.1.0-hexan-2-one) was moderately effective in the treatment of a retroviral infection in a genetically defined murine model. The animal model consisted of a Friend virus complex (FV) infection in a hybrid mouse strain, (B10.A x A/WySn)F1, which has similarities with acquired immune deficiency syndrome (AIDS). Intraperitoneal imexon initiated 1 or 3 days after FV inoculation and continued through 13 days after inoculation significantly reduced splenomegaly, splenic cell-free virus titers and viral RNA. Viral infectious centers/10(6) splenocytes and FV titers in the plasma were reduced, though not to a statistically significant level. The effect of imexon on survival was not statistically significant which suggested that the antiviral effects were only transiently effective. Phytohemagglutinin-induced blastogenesis and percent of total T cells, T helper cells and T suppressor/cytotoxic cells in the spleens were increased, and the percentage of B cells decreased by imexon treatment of both FV-infected and uninfected mice. The splenic natural killer cell activity and interleukin-1 production were not markedly affected. Virus specific neutralizing antibody developed in both imexon- and placebo-treated FV-infected mice, although titers were lower in the imexon-treated animals. C1 USA,MED RES INST INFECT DIS,FREDERICK,MD 21701. RP MORREY, JD (reprint author), UTAH STATE UNIV,AIDS RES PROGRAM,LOGAN,UT 84322, USA. FU NIAID NIH HHS [N01-AI-72662] NR 24 TC 10 Z9 10 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0166-3542 J9 ANTIVIR RES JI Antiviral Res. PD JAN PY 1991 VL 15 IS 1 BP 51 EP 66 DI 10.1016/0166-3542(91)90040-X PG 16 WC Pharmacology & Pharmacy; Virology SC Pharmacology & Pharmacy; Virology GA EX760 UT WOS:A1991EX76000005 PM 2036000 ER PT J AU ORSKOV, I WACHSMUTH, IK TAYLOR, DN ECHEVERRIA, P ROWE, B SAKAZAKI, R ORSKOV, F AF ORSKOV, I WACHSMUTH, IK TAYLOR, DN ECHEVERRIA, P ROWE, B SAKAZAKI, R ORSKOV, F TI 2 NEW ESCHERICHIA-COLI O-GROUPS - O172 FROM SHIGA-LIKE TOXIN II-PRODUCING STRAINS (EHEC) AND O173 FROM ENTEROINVASIVE ESCHERICHIA-COLI (EIEC) SO APMIS LA English DT Article DE ESCHERICHIA-COLI; SHIGA-LIKE TOXIN-II; NEW ESCHERICHIA-COLI O-GROUPS; ENTEROINVASIVE ESCHERICHIA-COLI; ANTIGEN CROSS REACTIONS AB Two Escherichia coli strains were established as antigenic test strains for two new O groups, O172 and O173. The O172 strain (EHEC) which produces >> Shiga-like << toxin II (verocytotoxin 2) was isolated from a case of haemorrhagic colitis while the enteroinvasive O173 strain (EIEC) originated from a child with diarrhoea. C1 ARMED FORCES RES INST MED SCI,BANGKOK,THAILAND. NATL INST HLTH,ENTEROBACTERIOL LABS,TOKYO 141,JAPAN. CENT PUBL HLTH LAB,DIV ENTER PATHOGENS,LONDON NW9 5HT,ENGLAND. CTR DIS CONTROL,ATLANTA,GA 30333. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. RP ORSKOV, I (reprint author), STATENS SERUM INST,WHO,COLLABORAT CTR REFERENCE & RES ESCHERICHIA,ARTILLERIVEJ 5,DK-2300 COPENHAGEN,DENMARK. NR 6 TC 18 Z9 19 U1 0 U2 0 PU MUNKSGAARD INT PUBL LTD PI COPENHAGEN PA 35 NORRE SOGADE, PO BOX 2148, DK-1016 COPENHAGEN, DENMARK SN 0903-4641 J9 APMIS JI APMIS PD JAN PY 1991 VL 99 IS 1 BP 30 EP 32 PG 3 WC Immunology; Microbiology; Pathology SC Immunology; Microbiology; Pathology GA EY365 UT WOS:A1991EY36500005 PM 1704241 ER PT J AU MCNESBY, KL FIFER, RA AF MCNESBY, KL FIFER, RA TI ROTATIONAL TEMPERATURE ESTIMATION OF CO AT HIGH-TEMPERATURES BY GRAPHICAL METHODS USING FT-IR SPECTROMETRY SO APPLIED SPECTROSCOPY LA English DT Article DE FLAME SPECTROSCOPY; INFRARED; ANALYTICAL METHODS ID FOURIER-TRANSFORM SPECTROMETRY; LIMITED INSTRUMENT RESOLUTION; ABSORBANCE MEASUREMENTS; ERRORS; LINES; BAND AB Rotational temperatures are obtained from gas-phase Fourier transformed infrared spectra of CO with the use of graphical methods over the temperature range 302 to 773 K. Peak absorbances of individual rovibrational transitions are corrected for instrumental distortion and are then fit to a Boltzmann distribution to obtain the rotational temperature of the gas. A solution to the convolution integral for FT-IR spectrometry is obtained by numerical integration. The equation relating observed peak absorbance, A(obs), to true peak absorbance, A(pm), ranging from one to five true peak absorbance units for triangularly apodized spectra is: A(pm) alpha A(obs)1.818rho-1.748 where the resolution parameter, rho, is equal to 1/(2-DELTA-gamma-m), gamma-m is the half-width at half-height (HWHH) of the absorption line in question, and DELTA is the maximum optical retardation of the interferometer (here equal to 1 cm). In all cases, temperatures obtained by graphical analysis yielded gas temperatures within 10% of the actual temperatures. Experiments were also conducted to determine the CO rotational temperature in a premixed, low-pressure (64 Torr) CH4/N2O flame. CO temperatures for the premixed flame ranged from 1500 to 1700 K, indicating a large transferral of heat from the flame to the burner chamber. RP MCNESBY, KL (reprint author), USA,BALLIST RES LABS,ABERDEEN PROVING GROUND,MD 21005, USA. NR 21 TC 1 Z9 1 U1 2 U2 4 PU SOC APPLIED SPECTROSCOPY PI FREDERICK PA PO BOX 1438, FREDERICK, MD 21701 SN 0003-7028 J9 APPL SPECTROSC JI Appl. Spectrosc. PD JAN PY 1991 VL 45 IS 1 BP 61 EP 67 DI 10.1366/0003702914337911 PG 7 WC Instruments & Instrumentation; Spectroscopy SC Instruments & Instrumentation; Spectroscopy GA EV359 UT WOS:A1991EV35900012 ER PT J AU STANLEY, AE TURNER, JB AF STANLEY, AE TURNER, JB TI SAMPLE ADSORPTION ON STAINLESS-STEEL SAMPLING VALVES SO APPLIED SPECTROSCOPY LA English DT Article DE GC; GC/MS; GAS SAMPLING VALVE C1 AUGUSTA COLL,CHEM & PHYS,AUGUSTA,GA 30904. RP STANLEY, AE (reprint author), USA,AMSMI RD RE QP,MISSILE COMMAND,REDSTONE ARSENAL,AL 35898, USA. NR 3 TC 1 Z9 1 U1 0 U2 0 PU SOC APPLIED SPECTROSCOPY PI FREDERICK PA PO BOX 1438, FREDERICK, MD 21701 SN 0003-7028 J9 APPL SPECTROSC JI Appl. Spectrosc. PD JAN PY 1991 VL 45 IS 1 BP 133 EP 133 DI 10.1366/0003702914337696 PG 1 WC Instruments & Instrumentation; Spectroscopy SC Instruments & Instrumentation; Spectroscopy GA EV359 UT WOS:A1991EV35900025 ER PT J AU SMITH, KJ SKELTON, HG JAMES, WD LUPTON, GP AF SMITH, KJ SKELTON, HG JAMES, WD LUPTON, GP TI PARAPOXVIRUS INFECTIONS ACQUIRED AFTER EXPOSURE TO WILDLIFE SO ARCHIVES OF DERMATOLOGY LA English DT Article ID ORF AB The histopathologic and electron microscopic findings in two patients with skin lesions that developed after exposure to deer and other wildlife were consistent with a parapoxviral infection. Human infections that were morphologically similar to Parapoxvirus infection have been previously described concerning exposure to cervids (deer and related animals). Ours are the first reported cases in which viral particles were demonstrated by electron microscopy. C1 ARMED FORCES INST PATHOL,DEPT DERMATOPATHOL,WASHINGTON,DC 20306. WALTER REED ARMY MED CTR,DEPT DERMATOL,WASHINGTON,DC 20307. NR 11 TC 12 Z9 12 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0003-987X J9 ARCH DERMATOL JI Arch. Dermatol. PD JAN PY 1991 VL 127 IS 1 BP 79 EP 82 DI 10.1001/archderm.127.1.79 PG 4 WC Dermatology SC Dermatology GA ET990 UT WOS:A1991ET99000011 PM 1846068 ER PT J AU OZER, MN SHANNON, SR AF OZER, MN SHANNON, SR TI RENAL SONOGRAPHY IN ASYMPTOMATIC PERSONS WITH SPINAL-CORD INJURY - A COST-EFFECTIVENESS ANALYSIS SO ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION LA English DT Article DE COST BENEFIT ANALYSIS; KIDNEY DISEASES; SPINAL CORD INJURIES ID ULTRASOUND AB A prospective study was undertaken to determine the cost effectiveness of the screening ultrasound examination during the annual check-up of persons with spinal cord injury (SCI). Fifty-two patients, who were otherwise free of illness at the time of examination, were questioned for a history of genitourinary (GU) symptoms and evaluated with a plain film KUB, 24-hour creatinine clearance determination, and and renal ultrasound. In those 36 patients without histories of GU symptoms, renal ultrsound alone discovered no treatable pathology. Of the 16 patients with histories of GU symptoms, renal ultrasound did not show treatable disease in in 13%. Effectiveness of the annual SCI follow-up may be maintained in the demonstration of treatable disease by the selective use of renal sonography only in those patients with histories of GU symptoms. C1 WALTER REED ARMY MED CTR,DEPT PHYS MED & REHABIL,WASHINGTON,DC 20307. RP OZER, MN (reprint author), HUNTER H MCGUIRE VET ADM MED CTR,SCI SERV,RICHMOND,VA, USA. NR 8 TC 8 Z9 8 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0003-9993 J9 ARCH PHYS MED REHAB JI Arch. Phys. Med. Rehabil. PD JAN PY 1991 VL 72 IS 1 BP 35 EP 37 PG 3 WC Rehabilitation; Sport Sciences SC Rehabilitation; Sport Sciences GA ET653 UT WOS:A1991ET65300009 PM 1898695 ER PT J AU BECKER, WK CIOFFI, WG MCMANUS, AT KIM, SH MCMANUS, WF MASON, AD PRUITT, BA AF BECKER, WK CIOFFI, WG MCMANUS, AT KIM, SH MCMANUS, WF MASON, AD PRUITT, BA TI FUNGAL BURN WOUND-INFECTION - A 10-YEAR EXPERIENCE SO ARCHIVES OF SURGERY LA English DT Article; Proceedings Paper CT 10TH ANNIVERSARY MEETING OF THE SURGICAL INFECTION SOC CY JUN 14-16, 1990 CL CINCINNATI, OH SP SURG INFECT SOC ID ASPERGILLOSIS AB To evaluate our experience with fungal burn wound infection, we performed a 10-year review for comparison with our experience with bacterial burn wound infection. During the study period, a marked decline occurred in bacterial wound infection but not in fungal wound infection. Patients with either bacterial or fungal burn wound infection had massive injury, with burn size averaging greater than 50% of the total body surface area. Factors that appear to have markedly reduced bacterial burn wound infection, including patient isolation, topical chemotherapeutic agents, and burn wound excision, do not appear to have had a similar effect on fungal wound infection. The mechanism of spread and colonization of fungi, and the lack of effective topical chemotherapeutic antifungal agents, may explain in part our findings. RP BECKER, WK (reprint author), USA,INST SURG RES,FT SAM HOUSTON,TX 78234, USA. NR 27 TC 72 Z9 74 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0004-0010 J9 ARCH SURG-CHICAGO JI Arch. Surg. PD JAN PY 1991 VL 126 IS 1 BP 44 EP 48 PG 5 WC Surgery SC Surgery GA ER433 UT WOS:A1991ER43300007 PM 1985634 ER PT J AU WAYMACK, JP FERNANDES, G CAPPELLI, PJ BURLESON, DG GUZMAN, RF MASON, AD PRUITT, BA AF WAYMACK, JP FERNANDES, G CAPPELLI, PJ BURLESON, DG GUZMAN, RF MASON, AD PRUITT, BA TI ALTERATIONS IN HOST DEFENSE ASSOCIATED WITH ANESTHESIA AND BLOOD-TRANSFUSIONS .2. EFFECT ON RESPONSE TO ENDOTOXIN SO ARCHIVES OF SURGERY LA English DT Article; Proceedings Paper CT 10TH ANNIVERSARY MEETING OF THE SURGICAL INFECTION SOC CY JUN 14-16, 1990 CL CINCINNATI, OH SP SURG INFECT SOC ID IMMUNE FUNCTION; SURGERY AB The effect of blood transfusions and anesthesia on host response to endotoxin was evaluated in multiple Lewis rat models. The rats were randomized to receive A'Sogaloff Cancer institute rat blood, pentobarbital sodium, or lactated Ringer's solution and, at either 2 or 7 days following administration of these agents, were challenged with intravenous endotoxin. Neither blood transfusions nor anesthesia altered mortality when administered 2 days before endotoxin challenge. However, blood transfusions administered 7 days before endotoxin challenge were found to prolong survival, to prevent endotoxin-induced alterations in T-lymphocyte subsets, and to decrease plasma tumor necrosis factor levels. In conclusion, blood transfusions appear to depress immune function in a beneficial manner in endotoxin shock. C1 UNIV TEXAS,HLTH SCI CTR,DEPT IMMUNOL,SAN ANTONIO,TX 78284. RP WAYMACK, JP (reprint author), USA,INST SURG RES,FT SAM HOUSTON,TX 78234, USA. NR 14 TC 19 Z9 19 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0004-0010 J9 ARCH SURG-CHICAGO JI Arch. Surg. PD JAN PY 1991 VL 126 IS 1 BP 59 EP 62 PG 4 WC Surgery SC Surgery GA ER433 UT WOS:A1991ER43300009 PM 1985635 ER PT J AU CIOFFI, WG BURLESON, DG JORDAN, BS BECKER, WK MCMANUS, WF MASON, AD PRUITT, BA AF CIOFFI, WG BURLESON, DG JORDAN, BS BECKER, WK MCMANUS, WF MASON, AD PRUITT, BA TI EFFECTS OF GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR IN BURN PATIENTS SO ARCHIVES OF SURGERY LA English DT Article; Proceedings Paper CT 10TH ANNIVERSARY MEETING OF THE SURGICAL INFECTION SOC CY JUN 14-16, 1990 CL CINCINNATI, OH SP SURG INFECT SOC ID HUMAN GM-CSF; MAJOR PHYSIOLOGICAL CHEMOATTRACTANTS; ENHANCED OXIDATIVE-METABOLISM; SEVERE THERMAL-INJURY; SUPPRESSOR T-CELLS; PLASMINOGEN-ACTIVATOR; PRIMES NEUTROPHILS; IMMUNE-RESPONSE; B-CELL; INVITRO AB We studied the effects of granulocyte-macrophage colony-stimulating factor in burn patients. Serial measurements of granulocyte oxidative function were obtained in treated patients and in a group of controls matched for age and total burn size. The administration of granulocyte-macrophage colony-stimulating factor resulted in a 50% increase in mean leukocyte counts. Both groups showed significant baseline increases in granulocytic cytosolic oxidative function. Treated patients showed normal stimulated cytosolic oxidative function, which was significantly depressed compared with that of untreated patients. Myeloperoxidase activity was increased in treated patients during the first postburn week but then declined to normal levels. Untreated patients had a significant increase in myeloperoxidase activity for the first 3 weeks following injury. Untreated patients exhibited a significant decrease in superoxide activity during the second 3 weeks following injury. Treated patients demonstrated normal superoxide activity. C1 USA,INST SURG RES,FT SAM HOUSTON,TX 78234. NR 39 TC 29 Z9 32 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0004-0010 J9 ARCH SURG-CHICAGO JI Arch. Surg. PD JAN PY 1991 VL 126 IS 1 BP 74 EP 79 PG 6 WC Surgery SC Surgery GA ER433 UT WOS:A1991ER43300012 PM 1845929 ER PT B AU CHANG, SKW GONZALEZ, RR AF CHANG, SKW GONZALEZ, RR BE Geshwiler, M TI AIR VELOCITY MAPPING OF ENVIRONMENTAL TEST CHAMBERS SO ASHRAE TRANSACTIONS 1991, VOL 97, PT 1 SE ASHRAE TRANSACTIONS LA English DT Proceedings Paper CT 1991 Winter Meeting of the American-Society-of-Heating-Refrigerating-and-Air-Conditioning-Engineers -Incorporated CY JAN 19-23, 1991 CL NEW YORK, NY SP AMER SOC HEATING REFRIGERATING & AIR CONDITIONING ENGINEERS INC C1 USA,ENVIRONM MED RES INST,DIV MIL ERGONOM,NATICK,MA 01760. NR 0 TC 2 Z9 2 U1 0 U2 0 PU AMER SOC HEATING, REFRIGERATING AND AIR-CONDITIONING ENGS PI ATLANTA PA 1791 TULLIE CIRCLE NE, ATLANTA, GA 30329 J9 ASHRAE TRAN PY 1991 VL 97 BP 31 EP 37 PN 1 PG 7 WC Construction & Building Technology; Engineering, Mechanical SC Construction & Building Technology; Engineering GA BA38X UT WOS:A1991BA38X00006 ER PT B AU UNDERWOOD, DM CRAWFORD, RR AF UNDERWOOD, DM CRAWFORD, RR BE Geshwiler, M TI DYNAMIC NONLINEAR MODELING OF A HOT-WATER-TO-AIR HEAT-EXCHANGER FOR CONTROL APPLICATIONS SO ASHRAE TRANSACTIONS 1991, VOL 97, PT 1 SE ASHRAE TRANSACTIONS LA English DT Proceedings Paper CT 1991 Winter Meeting of the American-Society-of-Heating-Refrigerating-and-Air-Conditioning-Engineers -Incorporated CY JAN 19-23, 1991 CL NEW YORK, NY SP AMER SOC HEATING REFRIGERATING & AIR CONDITIONING ENGINEERS INC C1 USA,CONSTRUCT ENGN RES LAB,CHAMPAIGN,IL. NR 0 TC 2 Z9 2 U1 0 U2 0 PU AMER SOC HEATING, REFRIGERATING AND AIR-CONDITIONING ENGS PI ATLANTA PA 1791 TULLIE CIRCLE NE, ATLANTA, GA 30329 J9 ASHRAE TRAN PY 1991 VL 97 BP 149 EP 155 PN 1 PG 7 WC Construction & Building Technology; Engineering, Mechanical SC Construction & Building Technology; Engineering GA BA38X UT WOS:A1991BA38X00020 ER PT B AU JONCICH, DM AF JONCICH, DM BE Geshwiler, M TI ACTIVE SOLAR THERMAL-ENERGY SYSTEMS IN THE UNITED-STATES-ARMY - STANDARDIZATION FOR MAXIMUM PERFORMANCE AND RELIABILITY SO ASHRAE TRANSACTIONS 1991, VOL 97, PT 1 SE ASHRAE TRANSACTIONS LA English DT Proceedings Paper CT 1991 Winter Meeting of the American-Society-of-Heating-Refrigerating-and-Air-Conditioning-Engineers -Incorporated CY JAN 19-23, 1991 CL NEW YORK, NY SP AMER SOC HEATING REFRIGERATING & AIR CONDITIONING ENGINEERS INC C1 USA,CONSTRUCT ENGN RES LAB,CHAMPAIGN,IL. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC HEATING, REFRIGERATING AND AIR-CONDITIONING ENGS PI ATLANTA PA 1791 TULLIE CIRCLE NE, ATLANTA, GA 30329 J9 ASHRAE TRAN PY 1991 VL 97 BP 189 EP 193 PN 1 PG 5 WC Construction & Building Technology; Engineering, Mechanical SC Construction & Building Technology; Engineering GA BA38X UT WOS:A1991BA38X00026 ER PT J AU MCCONKEY, IHK CASE, MP AF MCCONKEY, IHK CASE, MP BE Geshwiler, M TI ARTIFICIAL-INTELLIGENCE AS AN INTEGRATION TECHNOLOGY SO ASHRAE TRANSACTIONS 1991, VOL 97, PT 2 SE ASHRAE TRANSACTIONS LA English DT Proceedings Paper CT 1991 Annual Meeting of the American-Society-of-Heating-Refrigerating-and-Air-Conditioning-Engineers -Incorporated CY JUN 22-26, 1991 CL INDIANAPOLIS, IN SP AMER SOC HEATING REFRIGERATING & AIR CONDITIONING ENGINEERS INC C1 USA,CONSTRUCT ENGN LAB,CHAMPAIGN,IL. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER SOC HEATING, REFRIGERATING AND AIR-CONDITIONING ENGS PI ATLANTA PA 1791 TULLIE CIRCLE NE, ATLANTA, GA 30329 J9 ASHRAE TRAN PY 1991 VL 97 BP 761 EP 767 PN 2 PG 7 WC Construction & Building Technology; Engineering, Mechanical SC Construction & Building Technology; Engineering GA BA38Y UT WOS:A1991BA38Y00090 ER PT B AU SOHN, CW AF SOHN, CW BE Geshwiler, M TI FIELD PERFORMANCE OF AN ICE HARVESTER STORAGE COOLING SYSTEM SO ASHRAE TRANSACTIONS 1991, VOL 97, PT 2 SE ASHRAE TRANSACTIONS LA English DT Proceedings Paper CT 1991 Annual Meeting of the American-Society-of-Heating-Refrigerating-and-Air-Conditioning-Engineers -Incorporated CY JUN 22-26, 1991 CL INDIANAPOLIS, IN SP AMER SOC HEATING REFRIGERATING & AIR CONDITIONING ENGINEERS INC C1 USA,CONSTRUCT ENGN RES LAB,CHAMPAIGN,IL. NR 0 TC 11 Z9 11 U1 0 U2 0 PU AMER SOC HEATING, REFRIGERATING AND AIR-CONDITIONING ENGS PI ATLANTA PA 1791 TULLIE CIRCLE NE, ATLANTA, GA 30329 J9 ASHRAE TRAN PY 1991 VL 97 BP 1187 EP 1193 PN 2 PG 7 WC Construction & Building Technology; Engineering, Mechanical SC Construction & Building Technology; Engineering GA BA38Y UT WOS:A1991BA38Y00132 ER PT J AU HEWITT, AD CRAGIN, JH AF HEWITT, AD CRAGIN, JH TI CONTAMINATION OF AQUEOUS SAMPLES WITH FORMATE AND ACETATE FROM AMBIENT AIR SO ATMOSPHERIC ENVIRONMENT PART A-GENERAL TOPICS LA English DT Article DE FORMATE; ACETATE; VAPOR DIFFUSION; GAS LIQUID INTERFACE; AMBIENT EXPOSURE; SAMPLE CONTAMINATION ID REMOTE AREAS; ACETIC-ACIDS; PRECIPITATION; WORLD; SITE AB A sensitive ion chromatographic technique with detection limits of 1.9 and 6.2-mu-g l-1 has been developed for the determination of formate and acetate ions, respectively, in aqueous solution. Using this technique, uncovered aqueous solutions have been found to absorb the corresponding acids readily from ambient air at rates of approximately 0.02-0.1 nM cm-2 h-1. Consequently, to prevent vapor diffusion and subsequent contamination of environmental samples with these organic acids, casual exposure to ambient air, particularly in a laboratory, should be minimized. RP HEWITT, AD (reprint author), USA,COLD REG RES & ENGN LAB,HANOVER,NH 03755, USA. NR 11 TC 4 Z9 4 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0004-6981 J9 ATMOS ENVIRON A-GEN PY 1991 VL 25 IS 2 BP 453 EP 457 DI 10.1016/0960-1686(91)90315-X PG 5 WC Environmental Sciences; Meteorology & Atmospheric Sciences SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA EZ975 UT WOS:A1991EZ97500025 ER PT J AU RUBEL, GO AF RUBEL, GO TI PARTITIONING OF PARTIALLY SOLUBLE VOLATILES BETWEEN THE VAPOR AND LIQUID AEROSOL PHASE SO ATMOSPHERIC ENVIRONMENT PART A-GENERAL TOPICS LA English DT Article DE HENRYS LAW; AEROSOL; VAPOR PARTIAL PRESSURE ID ATMOSPHERE AB A model is derived predicting the partition of partially soluble volatile compound between the vapor and liquid aerosol phase. In the present model the activity of the volatile compound in the aerosol phase is described by Henry's Law for concentrations less than or equal to its solubility. It is shown that the partitioning of the volatile compound is dependent on two parameters: the aerosol to initial vapor mole concentration ratio, and the ratio of Henry's Law constant to initial vapor partial pressure. Representative calculations for a series of partially soluble volatile organic compounds show that the organic compounds favorably partition toward the vapor phase for most realistic aerosol mass concentrations. RP RUBEL, GO (reprint author), USA,MUNIT & CHEM COMMAND,CTR CHEM RES DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010, USA. NR 6 TC 4 Z9 4 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0004-6981 J9 ATMOS ENVIRON A-GEN PY 1991 VL 25 IS 5-6 BP 1009 EP 1012 DI 10.1016/0960-1686(91)90142-T PG 4 WC Environmental Sciences; Meteorology & Atmospheric Sciences SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences GA FF359 UT WOS:A1991FF35900017 ER PT J AU ASHANI, Y SHAPIRA, S LEVY, D WOLFE, AD DOCTOR, BP RAVEH, L AF ASHANI, Y SHAPIRA, S LEVY, D WOLFE, AD DOCTOR, BP RAVEH, L TI BUTYRYLCHOLINESTERASE AND ACETYLCHOLINESTERASE PROPHYLAXIS AGAINST SOMAN POISONING IN MICE SO BIOCHEMICAL PHARMACOLOGY LA English DT Article ID ENZYME AB Human butyrylcholinesterase (BChE, EC 3.1.1.8) or acetylcholinesterase (AChE, EC 3.1.1.7) from fetal bovine serum (FBS), administered i.v. in mice, sequestered at approximately 1:1 stoichiometry the highly toxic anti-ChE organophosphate, 1,2,2-trimethylpropyl methyl-fluorophosphonate (soman). A quantitative linear correlation was demonstrated between blood-ChE levels and the protection conferred by exogeneously administered ChE. Results presented here demonstrate that either human BChE or FBS-AChE is an effective prophylactic measure sufficient to protect mice from multiple LD50S of soman without the administration of post-treatment supportive drugs. C1 WALTER REED ARMY MED CTR,DIV BIOCHEM,WASHINGTON,DC 20307. RP ASHANI, Y (reprint author), ISRAEL INST BIOL RES,POB 19,IL-70450 NESS ZIONA,ISRAEL. NR 13 TC 107 Z9 109 U1 0 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0006-2952 J9 BIOCHEM PHARMACOL JI Biochem. Pharmacol. PD JAN 1 PY 1991 VL 41 IS 1 BP 37 EP 41 DI 10.1016/0006-2952(91)90008-S PG 5 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA EQ414 UT WOS:A1991EQ41400006 PM 1986743 ER PT J AU AKYEL, Y HUNT, EL GAMBRILL, C VARGAS, C AF AKYEL, Y HUNT, EL GAMBRILL, C VARGAS, C TI IMMEDIATE POSTEXPOSURE EFFECTS OF HIGH-PEAK-POWER MICROWAVE PULSES ON OPERANT-BEHAVIOR OF WISTAR RATS SO BIOELECTROMAGNETICS LA English DT Article DE SCHEDULE-CONTROLLED PERFORMANCE; REFLECTOR ANTENNA; DOSE DEPENDENCY; PULSED-MICROWAVES EFFECTS; HIGH-POWER MICROWAVES ID RADIATION AB Behavioral effects of high-peak-power microwave pulses on Wistar rats were studied by operant schedules. Each of twelve rats that had been trained to press a lever to receive food pellets was assigned randomly in groups of four to three different schedules of reinforcement: fixed-ratio (FR), variable-interval (VI), and differential-reinforcement-of-low-rates (DRL). After achieving a steady baseline performance, each animal was exposed for 10 min to 1.25-GHz microwave radiation at 1-MW peak-power (10-mu-s pulse width). Each pulse produced a peak whole-body SA and SAR of 2.1 J/kg and 0.21 MW/kg. Total doses (SAs) were set to 0.50, 1.5, 4.5, and 14 kJ/kg by adjusting the pulse-repetition rate. The corresponding time-averaged whole-body SARs were 0.84, 2.5, 7.6, and 23 W/kg. A microwave-transparent animal holder was used to keep the animal's body axis parallel to the E-field. Exposures at the highest dose caused an average colonic temperature rise of 2.5-degrees-C and these animals failed to respond at all for about 13 minutes after the exposure. Their colonic temperatures had decreased to 1.1-degrees-C, or less, above their pre-exposure (normal) temperature level when they began to respond. The FR and VI animals failed to reach their baseline levels of performance thereafter, while those on the DRL schedule displayed variable effects. No behavioral effects were found at the lower dose levels. It is concluded that the behavioral perturbations produced by pulsed microwave irradiation were thermal in nature. C1 WALTER REED ARMY MED CTR,DEPT MICROWAVE RES,WASHINGTON,DC 20307. RP AKYEL, Y (reprint author), ERC BIOSERV CORP,MONTGOMERY EXECUT CTR SUITE 222,6 MONTGOMERY VILLAGE AVE,GAITHERSBURG,MD 20879, USA. NR 15 TC 8 Z9 8 U1 0 U2 1 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0197-8462 J9 BIOELECTROMAGNETICS JI Bioelectromagnetics PY 1991 VL 12 IS 3 BP 183 EP 195 DI 10.1002/bem.2250120306 PG 13 WC Biology; Biophysics SC Life Sciences & Biomedicine - Other Topics; Biophysics GA FM271 UT WOS:A1991FM27100005 PM 1854355 ER PT J AU ROGERS, KR VALDES, JJ ELDEFRAWI, ME AF ROGERS, KR VALDES, JJ ELDEFRAWI, ME TI EFFECTS OF RECEPTOR CONCENTRATION, MEDIA PH AND STORAGE ON NICOTINIC RECEPTOR-TRANSMITTED SIGNAL IN A FIBEROPTIC BIOSENSOR SO BIOSENSORS & BIOELECTRONICS LA English DT Article DE NICOTINIC ACETYLCHOLINE RECEPTOR; BIOSENSOR; FIBEROPTIC; IMMOBILIZED RECEPTOR; FITC-NEUROTOXINS ID ACETYLCHOLINE-RECEPTOR; PROTEIN; SENSOR AB The optical signal generated by a nicotinic acetylcholine receptor (nAChR)-based optical biosensor was dependent on the density of toxin binding sites (i.e. receptors) immobilized on the surface of the fiber. The maximum density of nAChR receptors adsorbed on the optic fibers, measured using [I-125]-alpha-bungarotoxin (the alpha-neurotoxin of the Bungarus snake venom) binding, was 6.2 pmol of receptor sites per fiber. Incubation time, that was required for maximal noncovalent immobilization of the receptor protein on the fiber, was < 10 min. Immobilization of the nAChR protein on the quartz fiber was affected by pH of the medium, with pH 3.5 as the optimal. Stored in phosphate buffered saline (PBS) or in a dry nitrogen atmosphere, the nAChR optical sensor showed no loss of activity over the first 3 days, then showed a slow but gradual loss in activity (45% over the next 30 days). C1 UNIV MARYLAND,SCH MED,DEPT PHARMACOL & EXPTL THERAPEUT,655 W BALTIMORE ST,BALTIMORE,MD 21201. USA,CTR CHEM RES DEV & ENGN,DIV BIOTECHNOL,EDGEWOOD,MD 21010. NR 14 TC 27 Z9 28 U1 0 U2 0 PU ELSEVIER ADVANCED TECHNOLOGY PI OXFORD PA OXFORD FULFILLMENT CENTRE THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB SN 0956-5663 J9 BIOSENS BIOELECTRON JI Biosens. Bioelectron. PY 1991 VL 6 IS 1 BP 1 EP 8 DI 10.1016/0956-5663(91)85001-D PG 8 WC Biophysics; Biotechnology & Applied Microbiology; Chemistry, Analytical; Electrochemistry; Nanoscience & Nanotechnology SC Biophysics; Biotechnology & Applied Microbiology; Chemistry; Electrochemistry; Science & Technology - Other Topics GA FF429 UT WOS:A1991FF42900001 PM 2049167 ER PT J AU ROGERS, KR ELDEFRAWI, ME MENKING, DE THOMPSON, RG VALDES, JJ AF ROGERS, KR ELDEFRAWI, ME MENKING, DE THOMPSON, RG VALDES, JJ TI PHARMACOLOGICAL SPECIFICITY OF A NICOTINIC ACETYLCHOLINE-RECEPTOR OPTICAL SENSOR SO BIOSENSORS & BIOELECTRONICS LA English DT Article DE NICOTINIC ACETYLCHOLINE RECEPTOR; FIBER OPTIC BIOSENSOR; FLUORESCEIN TAGGED TOXINS ID NAJA-NIGRICOLLIS ALPHA-TOXIN; TRITIATED ALPHA-NEUROTOXIN; TORPEDO ELECTRIC ORGANS; MEMBRANE FRAGMENTS; GLUCOSE SENSOR; BINDING; BIOSENSORS; CHANNEL; ELECTROPHORUS; BUNGAROTOXIN AB The pharmacological specificity of a nicotinic acetylcholine receptor (nAChR) optical biosensor was investigated using three fluorescein isothiocyanate (FITC)-tagged neurotoxic peptides that vary in the reversibility of their receptor inhibition: alpha-bungarotoxin (alpha-BGT), alpha-Naja toxin (alpha-NT), and alpha-conotoxin (GI) (alpha-CNTX). Kinetic analysis of the time course of binding of FITC-neurotoxins to the nAChR-coated fiber gave association rate constants (k +1) of 8.4 x 10(6) M-1 min-1 for FITC-alpha-BGT, 6.0 x 10(6) M-1 min-1 for FITC-alpha-NT and 1.4 x 10(6) M-1 min-1 for FITC-alpha-CNTX. The dissociation rate constants (k -1) for the three neurotoxins were 7.9 x 10(-3) min-1, 4.8 x 10(-2) min-1 and 8.0 x 10(-1) min-1 for FITC-alpha-BGT, FITC-alpha-NT and FITC-alpha-CNTX, respectively. The equilibrium dissociation constant (K(d)) values for the three toxins, calculated from these rare constants, were similar to published values obtained from tissue responses or ligand binding assays. The optical signal generated by FITC-alpha-NT binding to the nAChR-coated fiber was effectively quenched by agonists and antagonists of the nAChR but not by most of the tested agonists and antagonists of muscarinic cholinergic, adrenergic, glutamatergic, serotonergic, dopaminergic or GABAergic receptors. Interestingly, 5-hydroxy-tryptamine, haloperidol and (+)cis-methyldioxolane gave significant inhibition of FITC-alpha-NT binding to the immobilized receptor. Equilibrium constants of inhibition (K(i)) for d-tubocurarine (d-TC) and carbamylcholine (carb) were determined from competition studies using FITC-alpha-CNTX. FITC-alpha-NT or FITC-alpha-BGT as probes for receptor occupancy. When the more reversible probe FITC-alpha-CNTX was used, the K(i) value for d-TC was an order of magnitude lower than those determined using the less reversible probes. K(i) values for carb, however, were independent of the FITC-toxin probe used. C1 UNIV MARYLAND,DEPT PHARMACOL & EXPTL THERAPEUT,BALTIMORE,MD 21201. USA,CTR RES DEV & ENGN,DIV BIOTECHNOL,EDGEWOOD,MD 21010. NR 38 TC 24 Z9 24 U1 0 U2 0 PU ELSEVIER ADVANCED TECHNOLOGY PI OXFORD PA OXFORD FULFILLMENT CENTRE THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB SN 0956-5663 J9 BIOSENS BIOELECTRON JI Biosens. Bioelectron. PY 1991 VL 6 IS 6 BP 507 EP 516 DI 10.1016/0956-5663(91)85048-2 PG 10 WC Biophysics; Biotechnology & Applied Microbiology; Chemistry, Analytical; Electrochemistry; Nanoscience & Nanotechnology SC Biophysics; Biotechnology & Applied Microbiology; Chemistry; Electrochemistry; Science & Technology - Other Topics GA FY203 UT WOS:A1991FY20300005 PM 1910671 ER PT J AU ANDREAS, EL AF ANDREAS, EL TI USING SCINTILLATION AT 2 WAVELENGTHS TO MEASURE PATH-AVERAGED HEAT FLUXES IN FREE-CONVECTION SO BOUNDARY-LAYER METEOROLOGY LA English DT Article ID INDEX-STRUCTURE PARAMETER; BOUNDARY-LAYER; REFRACTIVE-INDEX; TURBULENCE STRUCTURE; INNER SCALE; TEMPERATURE; BEHAVIOR; SIMILARITY; MOISTURE; HUMIDITY AB Local free convection scaling is one of the obvious triumphs of boundary-layer similarity theory. In free convection, there is no dynamic velocity scale; the sensible and latent heat fluxes, therefore, scale directly with the temperature and humidity structure parameters C(t)2 and C(q)2. By using scintillation to measure the refractive index structure parameter C(n)2 at two electromagnetic (EM) wavelengths, we can obtain C(t)2 and C(q)2 and, thus, in effect, measure path-averaged values of the sensible and latent heat fluxes. Here I describe this so-called two-wavelength method for free convection, derive quantitative guidelines for optimizing the method, and evaluate its potential accuracy. I show that the two-wavelength method works best when one EM wavelength is in the visible or infrared region and the other is in the millimeter or radio region. When the Bowen ratio is between -5 and -0.1 or between 0.1 and 5, the expected accuracy of the measured fluxes is +/- 10-20% - typical of what is possible with eddy-correlation measurements. With the two-wavelength method, however, the fluxes represent spatial averages. RP ANDREAS, EL (reprint author), USA,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 37 TC 15 Z9 15 U1 0 U2 0 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 0006-8314 J9 BOUND-LAY METEOROL JI Bound.-Layer Meteor. PD JAN PY 1991 VL 54 IS 1-2 BP 167 EP 182 DI 10.1007/BF00119418 PG 16 WC Meteorology & Atmospheric Sciences SC Meteorology & Atmospheric Sciences GA EW110 UT WOS:A1991EW11000010 ER PT J AU CHANG, FCT AF CHANG, FCT TI EFFECTS OF PENTOBARBITAL ON RESPIRATORY FUNCTIONAL DYNAMICS IN CHRONICALLY INSTRUMENTED GUINEA-PIGS SO BRAIN RESEARCH BULLETIN LA English DT Article DE SODIUM PENTOBARBITAL; RESPIRATION; CHRONIC SINGLE UNIT RECORDING; DIAPHRAGMATIC EMG; GUINEA PIGS ID FOCAL COLD BLOCK; EXPIRATORY NEURONS; BOTZINGER COMPLEX; MEDULLA; CAT; AWAKE; PROJECTIONS; REFLEX AB Respiratory effects of sodium pentobarbital (35 mg/kg; IP) were studied in guinea pigs chronically instrumented to permit concurrent recordings of bulbar respiratory-related units (RRUs), diaphragmatic electromyogram (DEMG), and electrocorticogram (ECoG). RRU activities were recorded from either the Botzinger Complex (BOT; expiratory) or Nucleus para-Ambiguus (NpA; inspiratory). Pentobarbital-induced changes in respiratory-related activities were evaluated before, throughout the course of, and during recovery from, anesthesia. The most notable development following pentobarbital was a state of progressive bradypnea which was accompanied by a variety of complex changes in the amplitude and temporal attributes of RRU, DEMG and ECoG activities. As anesthetic effects progressed, the activity profiles of both BOT and NpA units underwent striking transformations from a behavioral and state-dependent wakefulness pattern to an activity profile characterized by i) a significantly augmented RRU cycle duration, burst duration and spike frequency; and, ii) an alteration to the pattern of within-burst spike frequency modulation. Along with changes in RRU activity, pentobarbital also produced a marked attenuation of the amplitudes of diaphragmatic activity as well as a discrete, time-dependent alteration in the amplitude and spectral characters of ECoG activities. Differences in BOT and NpA unit responses to alveolar CO2 loading (ramp; 2% and 5%) across wakefulness and anesthesia states were also considerable. In addition to a depressed responsiveness to CO2, the temporal attributes of BOT and NpA activity profiles also indicated an asymmetrical change under pentobarbital anesthesia. Taken together, these findings indicate that pentobarbital causes not only a fundamental alteration in bulbar rhythmogenic mechanisms, but also a differential influence on bulbar respiratory system components that are involved in the definition of the shape and the amplitude of central respiratory drive. In conclusion, this study offers, for the first time, direct evidence from physiologically and structurally intact preparations that the functional dynamics of respiratory system components are profoundly altered during pentobarbital anesthesia. RP CHANG, FCT (reprint author), USA,MED RES INST CHEM DEF,DIV PATHOPHYSIOL,NEUROTOXICOL BRANCH,ABERDEEN PROVING GROUND,MD 21010, USA. NR 31 TC 7 Z9 7 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0361-9230 J9 BRAIN RES BULL JI Brain Res. Bull. PD JAN PY 1991 VL 26 IS 1 BP 123 EP 132 DI 10.1016/0361-9230(91)90196-Q PG 10 WC Neurosciences SC Neurosciences & Neurology GA EV214 UT WOS:A1991EV21400013 PM 1901751 ER PT J AU HARTMAN, KR TRICHE, TJ KINSELLA, TJ MISER, JS AF HARTMAN, KR TRICHE, TJ KINSELLA, TJ MISER, JS TI PROGNOSTIC VALUE OF HISTOPATHOLOGY IN EWINGS-SARCOMA - LONG-TERM FOLLOW-UP OF DISTAL EXTREMITY PRIMARY TUMORS SO CANCER LA English DT Article ID PERIPHERAL NEUROECTODERMAL TUMORS; COMBINED MODALITY THERAPY; YOUNG-ADULTS; BONE; NEUROEPITHELIOMA; CHILDHOOD; CHILDREN; MAINTENANCE; DIAGNOSIS AB The pathologic material from 56 patients diagnosed initially as Ewing's sarcoma of the distal extremity and treated on National Cancer Institute protocols between 1968 and 1984 was reviewed and correlated with clinical outcome. Histologically, the tumors were categorized, based on recent pathologic criteria, into three diagnostic groups: (1) typical Ewing's sarcoma, (2) atypical Ewing's sarcoma, and (3) other (predominantly peripheral neuroepithelioma [PN]). Thirty-two patients (57%) had typical Ewing's, 13 (23%) were atypical, and 11 (20%) were in the "other" diagnostic category (seven [13%] PN, two primitive rhabdomyosarcoma, one primitive sarcoma of bone, and one synovial cell sarcoma). No cases of metastatic neuroblastoma, osteosarcoma, or lymphoma were found. Forty-five patients had localized disease at diagnosis; 11 had metastases. Patients with typical Ewing's sarcoma were less likely to have metastatic disease at the time of diagnosis. Only two of 32 patients with typical Ewing's sarcoma had metastases compared with nine of 24 patients in the two other groups. The pattern of relapse was also different in these other groups compared with typical Ewing's patients; five patients developed lymp node metastases and two patients developed brain metastases. Although the presence of metastatic disease at diagnosis was a strong negative prognostic factor, our histologic grouping was independently prognostic of clinical outcome in patients with localized disease. Patients with typical osseous Ewing's sarcoma had an improved overall survival (P2 = 0.03) and patients with other tumors (neither typical nor atypical Ewing's sarcoma) had a poorer disease-free survival (P2 = 0.02). Since no generally accepted histopathologic prognostic criteria exist for Ewing's sarcoma, the potential value of our proposed classification should be evaluated in a larger retrospective and a prospective study. C1 UNIV SO CALIF,CHILDRENS HOSP LOS ANGELES,DEPT PATHOL & LAB MED,4650 SUNSET BLVD,LOS ANGELES,CA 90027. WALTER REED ARMY MED CTR,DIV PEDIAT HEMATOL ONCOL,WASHINGTON,DC 20307. UNIV WISCONSIN,CTR CLIN CANC,MADISON,WI 53706. MAYO CLIN & MAYO FDN,DEPT PEDIAT,ROCHESTER,MN 55905. NR 34 TC 62 Z9 62 U1 0 U2 1 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0008-543X J9 CANCER JI Cancer PD JAN 1 PY 1991 VL 67 IS 1 BP 163 EP 171 DI 10.1002/1097-0142(19910101)67:1<163::AID-CNCR2820670128>3.0.CO;2-Y PG 9 WC Oncology SC Oncology GA EQ089 UT WOS:A1991EQ08900027 PM 1985713 ER PT J AU ROSSIN, J PETERSEN, E TEVAULT, D LAMONTAGNE, R ISAACSON, L AF ROSSIN, J PETERSEN, E TEVAULT, D LAMONTAGNE, R ISAACSON, L TI EFFECTS OF ENVIRONMENTAL WEATHERING ON THE PROPERTIES OF ASC-WHETLERITE SO CARBON LA English DT Article DE ASC; EDS; WEATHERING; WHETLERITE; XPS AB Activated, impregnated carbon from a radial flow air purification filter was separated into fractions after the filter had been exposed to shipboard environmental conditions for 21 months. Carbon samples from the discrete filter locations were analyzed using surface analysis methods. Breakthrough times of the segregated carbon fractions were recorded for a cyanogen chloride challenge. The inlet portion of the filter was most severely affected by the weathering. For carbon removed from the filter inlet, the weathering process caused impregnants to leach from the granules and form metal sulfates, presumably by reaction with atmospheric SO(x). No sulfur was detected on carbon samples removed from the center and outlet portions of the filter; however, a significant fraction of the chromium (VI) impregnant had been reduced to chromium(III). In all cases, breakthrough times recorded for a cyanogen chloride challenge were significantly less than that recorded for the unweathered carbon sample. C1 USN,RES LAB,WASHINGTON,DC 20375. GEOCENTERS INC,FT WASHINGTON,MD 20744. RP ROSSIN, J (reprint author), USA,CHEM RED DEV & ENGN CTR,AIR PURIFICAT BRANCH,ABERDEEN PROVING GROUND,MD 21010, USA. NR 8 TC 16 Z9 16 U1 1 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0008-6223 J9 CARBON JI Carbon PY 1991 VL 29 IS 2 BP 197 EP 205 DI 10.1016/0008-6223(91)90070-Y PG 9 WC Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA EW765 UT WOS:A1991EW76500009 ER PT J AU ROSSIN, JA MORRISON, RW AF ROSSIN, JA MORRISON, RW TI SPECTROSCOPIC ANALYSIS AND PERFORMANCE OF AN EXPERIMENTAL COPPER-ZINC IMPREGNATED, ACTIVATED CARBON SO CARBON LA English DT Article DE WHETLERITE; ACTIVATED CARBON; HYDROGEN CYANIDE ID HYDROGEN-CYANIDE; CHARCOAL AB An experimental copper/zinc/silver/triethylenediamine-impregnated, activated carbon formulation has been developed for removal of hydrogen cyanide from streams of air. The material consists of a zinc phase highly concentrated at the external surface of the granule and a copper phase distributed throughout the granule. This material performed well when first exposed to a hydrogen cyanide feed. Following prolonged humid exposure, cyanogen, a reaction product of hydrogen cyanide, broke through the carbon bed prematurely. The premature cyanogen breakthrough was attributed to the migration of copper to the external surface of the carbon granule. Results of this paper demonstrate the importance of the impregnant distribution within the granule on the carbon's performance against a hydrogen cyanide feed. C1 USA,CRDEC,ABERDEEN PROVING GROUND,MD 21010. RP ROSSIN, JA (reprint author), GEOCENTERS INC,FT WASHINGTON,MD 20744, USA. NR 13 TC 20 Z9 22 U1 2 U2 6 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0008-6223 J9 CARBON JI Carbon PY 1991 VL 29 IS 7 BP 887 EP 892 DI 10.1016/0008-6223(91)90164-E PG 6 WC Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA GF179 UT WOS:A1991GF17900010 ER PT J AU KARWACKI, CJ STICKEL, GA AF KARWACKI, CJ STICKEL, GA TI INFLUENCE OF MOISTURE-CONTENT ON THE BREAKTHROUGH BEHAVIOR OF PERFLUOROISOBUTENE SO CARBON LA English DT Letter DE ACTIVATED CARBON; PERFLUOROISOBUTENE; MOISTURE CONTENT RP KARWACKI, CJ (reprint author), USA,CTR CHEM RES DEV & ENGN,SMCCR,PPC,ABERDEEN PROVING GROUND,MD 21010, USA. NR 7 TC 2 Z9 2 U1 1 U2 4 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0008-6223 J9 CARBON JI Carbon PY 1991 VL 29 IS 8 BP 1292 EP 1294 DI 10.1016/0008-6223(91)90050-S PG 3 WC Chemistry, Physical; Materials Science, Multidisciplinary SC Chemistry; Materials Science GA GP949 UT WOS:A1991GP94900029 ER PT J AU PREWITT, KC WORTHAM, DC BANKS, AK AF PREWITT, KC WORTHAM, DC BANKS, AK TI CORONARY ANGIOPLASTY FOLLOWING CARDIAC TRANSPLANTATION - A CASE-REPORT AND REVIEW OF THE LITERATURE SO CATHETERIZATION AND CARDIOVASCULAR DIAGNOSIS LA English DT Article DE CORONARY ANGIOPLASTY; CARDIAC TRANSPLANTATION; CORONARY ARTERY DISEASE ID ARTERIOSCLEROSIS; DISEASE; PATIENT AB A 23-year-old man underwent successful percutaneous transluminal coronary angioplasty of a severe stenosis of the left anterior descending artery 25 months after orthotopic heart transplantation. Four months later restenosis of the same lesion was treated by repeat PTCA. Angiography 11 months later showed no restenosis. In selected cases, PTCA may be useful in treating allograft coronary disease. RP PREWITT, KC (reprint author), WALTER REED ARMY MED CTR,DEPT MED,CARDIOL SERV,WASHINGTON,DC 20307, USA. NR 11 TC 1 Z9 1 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0098-6569 J9 CATHETER CARDIO DIAG JI Catheter. Cardiovasc. Diagn. PD JAN PY 1991 VL 22 IS 1 BP 25 EP 27 DI 10.1002/ccd.1810220106 PG 3 WC Cardiac & Cardiovascular Systems SC Cardiovascular System & Cardiology GA ER658 UT WOS:A1991ER65800005 PM 1995170 ER PT J AU BETLYON, JW AF BETLYON, JW TI CULTS OF THE DEAD IN ANCIENT-ISRAEL AND UGARIT - LEWIS,TJ SO CATHOLIC BIBLICAL QUARTERLY LA English DT Book Review RP BETLYON, JW (reprint author), US ARMY INFANTRY TRAINING CTR,FT BENNING,GA 31905, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU CATHOLIC BIBLICAL ASSN AMER PI WASHINGTON PA CATHOLIC UNIV AMERICA 620 MICHIGAN AVE, NE, WASHINGTON, DC 20064 SN 0008-7912 J9 CATH BIBLICAL QUART JI Cathol. Biblic. Q. PD JAN PY 1991 VL 53 IS 1 BP 108 EP 110 PG 3 WC Religion SC Religion GA EZ558 UT WOS:A1991EZ55800020 ER PT B AU BERNTON, E DAVE, J AF BERNTON, E DAVE, J BE MELTZER, MS MANTOVANI, A TI PROLACTIN, GROWTH-HORMONE, AND IMMUNE HOMEOSTASIS SO CELLULAR AND CYTOKINE NETWORKS IN TISSUE IMMUNITY SE PROGRESS IN LEUKOCYTE BIOLOGY LA English DT Proceedings Paper CT 27TH ANNUAL MEETING OF THE SOC FOR LEUKOCYTE BIOLOGY CY OCT 14-18, 1990 CL HERAKLION, GREECE SP SOC LEUKOCYTE BIOL RP BERNTON, E (reprint author), WALTER REED ARMY MED CTR,DEPT MED NEUROSCI,DIV NEUROPSYCHIAT,NEUROPHARMACOL BRANCH,WASHINGTON,DC 20307, USA. NR 0 TC 1 Z9 1 U1 0 U2 0 PU WILEY-LISS, INC PI NEW YORK PA NEW YORK BN 0-471-56097-9 J9 PROG LEUC B PY 1991 VL 11 BP 69 EP 75 PG 7 WC Immunology SC Immunology GA BU85E UT WOS:A1991BU85E00010 ER PT B AU MELTZER, MS BACA, LM TURPIN, JA KALTER, DC DIEFFENBACH, C FRIEDMAN, RM GENDELMAN, HE AF MELTZER, MS BACA, LM TURPIN, JA KALTER, DC DIEFFENBACH, C FRIEDMAN, RM GENDELMAN, HE BE MELTZER, MS MANTOVANI, A TI SUBVERSION OF THE CYTOKINE NETWORK OF T-CELL-MACROPHAGE INTERACTION BY THE HUMAN-IMMUNODEFICIENCY-VIRUS SO CELLULAR AND CYTOKINE NETWORKS IN TISSUE IMMUNITY SE PROGRESS IN LEUKOCYTE BIOLOGY LA English DT Proceedings Paper CT 27TH ANNUAL MEETING OF THE SOC FOR LEUKOCYTE BIOLOGY CY OCT 14-18, 1990 CL HERAKLION, GREECE SP SOC LEUKOCYTE BIOL RP MELTZER, MS (reprint author), WALTER REED ARMY MED CTR,DEPT CELL IMMUNOL,ROCKVILLE,MD 20850, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-LISS, INC PI NEW YORK PA NEW YORK BN 0-471-56097-9 J9 PROG LEUC B PY 1991 VL 11 BP 205 EP 212 PG 8 WC Immunology SC Immunology GA BU85E UT WOS:A1991BU85E00030 ER PT B AU KALTER, DC GENDELMAN, HE MELTZER, MS AF KALTER, DC GENDELMAN, HE MELTZER, MS BE MELTZER, MS MANTOVANI, A TI ROLE OF LEUKOCYTE ADHESINS IN THE INFECTION OF MONOCYTES AND T-CELLS BY THE HUMAN IMMUNODEFICIENCY VIRUS-1 (HIV) SO CELLULAR AND CYTOKINE NETWORKS IN TISSUE IMMUNITY SE PROGRESS IN LEUKOCYTE BIOLOGY LA English DT Proceedings Paper CT 27TH ANNUAL MEETING OF THE SOC FOR LEUKOCYTE BIOLOGY CY OCT 14-18, 1990 CL HERAKLION, GREECE SP SOC LEUKOCYTE BIOL RP KALTER, DC (reprint author), WALTER REED ARMY MED CTR,HM JACKSON FDN,ROCKVILLE,MD 20850, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-LISS, INC PI NEW YORK PA NEW YORK BN 0-471-56097-9 J9 PROG LEUC B PY 1991 VL 11 BP 213 EP 219 PG 7 WC Immunology SC Immunology GA BU85E UT WOS:A1991BU85E00031 ER PT B AU GREEN, SJ FORTIER, AH CRAWFORD, RM MELTZER, MS NACY, CA AF GREEN, SJ FORTIER, AH CRAWFORD, RM MELTZER, MS NACY, CA BE MELTZER, MS MANTOVANI, A TI FRANCISELLA-TULARENSIS IS SUSCEPTIBLE TO NITROGEN-OXIDES PRODUCED BY CYTOKINE-ACTIVATED MURINE MACROPHAGES SO CELLULAR AND CYTOKINE NETWORKS IN TISSUE IMMUNITY SE PROGRESS IN LEUKOCYTE BIOLOGY LA English DT Proceedings Paper CT 27TH ANNUAL MEETING OF THE SOC FOR LEUKOCYTE BIOLOGY CY OCT 14-18, 1990 CL HERAKLION, GREECE SP SOC LEUKOCYTE BIOL RP GREEN, SJ (reprint author), WALTER REED ARMY MED CTR,DEPT CELL IMMUNOL,9620 MED CTR DR,ROCKVILLE,MD 20850, USA. NR 0 TC 2 Z9 2 U1 0 U2 0 PU WILEY-LISS, INC PI NEW YORK PA NEW YORK BN 0-471-56097-9 J9 PROG LEUC B PY 1991 VL 11 BP 235 EP 240 PG 6 WC Immunology SC Immunology GA BU85E UT WOS:A1991BU85E00034 ER PT B AU NACY, CA NELSON, BJ GREEN, SJ MEIEROVICS, AI AF NACY, CA NELSON, BJ GREEN, SJ MEIEROVICS, AI BE MELTZER, MS MANTOVANI, A TI CYTOKINE NETWORKS AND REGULATION OF MACROPHAGE ANTIMICROBIAL ACTIVITIES SO CELLULAR AND CYTOKINE NETWORKS IN TISSUE IMMUNITY SE PROGRESS IN LEUKOCYTE BIOLOGY LA English DT Proceedings Paper CT 27TH ANNUAL MEETING OF THE SOC FOR LEUKOCYTE BIOLOGY CY OCT 14-18, 1990 CL HERAKLION, GREECE SP SOC LEUKOCYTE BIOL RP NACY, CA (reprint author), WALTER REED ARMY MED CTR,DEPT CELLULAR IMMUNOL,9620 MED CTR DR,ROCKVILLE,MD 20850, USA. NR 0 TC 3 Z9 3 U1 0 U2 0 PU WILEY-LISS, INC PI NEW YORK PA NEW YORK BN 0-471-56097-9 J9 PROG LEUC B PY 1991 VL 11 BP 271 EP 276 PG 6 WC Immunology SC Immunology GA BU85E UT WOS:A1991BU85E00040 ER PT B AU LEIBY, DA FORTIER, AH SCHREIBER, RD NACY, CA AF LEIBY, DA FORTIER, AH SCHREIBER, RD NACY, CA BE MELTZER, MS MANTOVANI, A TI REGULATION OF MURINE INFECTIONS WITH FRANCISELLA-TULARENSIS (LVS) BY ALTERING THE ACTIVITY OF TH1 AND TH2 CELL-POPULATIONS WITH ANTI-CYTOKINE ANTIBODIES SO CELLULAR AND CYTOKINE NETWORKS IN TISSUE IMMUNITY SE PROGRESS IN LEUKOCYTE BIOLOGY LA English DT Proceedings Paper CT 27TH ANNUAL MEETING OF THE SOC FOR LEUKOCYTE BIOLOGY CY OCT 14-18, 1990 CL HERAKLION, GREECE SP SOC LEUKOCYTE BIOL RP LEIBY, DA (reprint author), WALTER REED ARMY MED CTR,DEPT CELLULAR IMMUNOL,ROCKVILLE,MD 20850, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILEY-LISS, INC PI NEW YORK PA NEW YORK BN 0-471-56097-9 J9 PROG LEUC B PY 1991 VL 11 BP 277 EP 282 PG 6 WC Immunology SC Immunology GA BU85E UT WOS:A1991BU85E00041 ER PT J AU DHILLON, GS KOENIG, ML AF DHILLON, GS KOENIG, ML TI EVIDENCE THAT METABOLICALLY ACTIVE SYNAPTOSOMES LACK FUNCTIONAL CYCLIC AMP-DEPENDENT PROTEIN-KINASE SO CELLULAR SIGNALLING LA English DT Article DE SYNAPTOSOMES; CEREBRAL CORTEX; ADENYLATE CYCLASE; CYCLIC AMP-DEPENDENT PROTEIN KINASE ID PIG CEREBRAL-CORTEX; RAT CORTICAL SYNAPTOSOMES; CELL-FREE PREPARATIONS; ADENYLATE-CYCLASE; BRAIN SYNAPTOSOMES; GENERATING SYSTEMS; ENDOGENOUS DOPAMINE; CALCIUM CHANNELS; RELEASE; PHOSPHORYLATION AB Cyclic adenosine monophosphate (cAMP)-mediated signal transduction was evaluated in synaptosomes prepared from rat brain cortex. Adenylate cyclase was responsive to known adenylate cyclase stimulators including peptides (CRH and VIP), catecholamines (norepinephrine and isoproterenol) and ligands that directly stimulate adenylate cyclase (forskolin). Cyclic AMP accumulation also increased approximately 2 to 3-fold, but none of the agonists was able significantly to activate cyclic AMP-dependent protein kinase (A-kinase) in cortical synaptosomes. However, in parallel studies with slices prepared from rat brain cortex, adenylate cyclase activity, cAMP accumulation and A-kinase activity were all stimulated by CRH, VIP, norepinephrine, isoproterenol and forskolin. These data suggest that, in intact synaptosomes, either the cellular machinery which facilitates binding of cAMP to the regulatory subunit of A-kinase is missing or the cAMP produced by adenylate cyclase is not accessible to A-kinase. C1 WALTER REED ARMY MED CTR,DEPT MED NEUROSCI,DIV NEUROPSYCHIAT,WASHINGTON,DC 20307. NR 57 TC 1 Z9 1 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0898-6568 J9 CELL SIGNAL JI Cell. Signal. PY 1991 VL 3 IS 5 BP 425 EP 434 DI 10.1016/0898-6568(91)90073-4 PG 10 WC Cell Biology SC Cell Biology GA GN970 UT WOS:A1991GN97000006 PM 1760253 ER PT J AU WELLINGTON, DR MITCHELL, WR AF WELLINGTON, DR MITCHELL, WR TI INVITRO CYTOTOXICITY OF CERTAIN MUNITION NITROAROMATIC COMPOUNDS SO CHEMOSPHERE LA English DT Article ID CYTO-TOXICITY; DINITROTOLUENES; INDUCTION; CELLS; ASSAY AB Neutral red (NR) uptake assays in the rat liver hepatoma H4IIE cell line were employed to compare the cytotoxicities of the explosive 2,4,6-trinitrotoluene, four of the principal nitroaromatic pollutants associated with its manufacture, and monoamines with the potential to be formed from the compounds in the environment. The assay system was responsive to all munition associated compounds tested and their corresponding amines. The order of cytotoxicity for the nitroaromatic compounds in vitro was 1,3,5-trinitrobenzene > 2,4,6-trinitrotoluene > 1,3-dinitrobenzene > 2,4- and 2,6-dinitrotoluenes and was in general agreement with that of other systems used for munition toxicity screening. Most of the amino nitroaromatic compounds were similar to each other in their cytotoxic potency, and most were less toxic than their nitroaromatic analogues. C1 USA,BIOMED RES & DEV LAB,DIV HLTH EFFECTS RES,FT DETRICK,FREDERICK,MD 21702. NR 34 TC 28 Z9 28 U1 2 U2 3 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0045-6535 J9 CHEMOSPHERE JI Chemosphere PY 1991 VL 23 IS 3 BP 363 EP 373 DI 10.1016/0045-6535(91)90190-O PG 11 WC Environmental Sciences SC Environmental Sciences & Ecology GA GL916 UT WOS:A1991GL91600010 ER PT J AU OTHOUDT, RA GIESY, JP GRZYB, KR VERBRUGGE, DA HOKE, RA DRAKE, JB ANDERSON, D AF OTHOUDT, RA GIESY, JP GRZYB, KR VERBRUGGE, DA HOKE, RA DRAKE, JB ANDERSON, D TI EVALUATION OF THE EFFECTS OF STORAGE TIME ON THE TOXICITY OF SEDIMENTS SO CHEMOSPHERE LA English DT Article AB With the need to collect large numbers of sediment samples and the limited number of laboratory personnel it would be beneficial to be able to store samples longer than the currently suggested 14 day period. Using D. magna and C. tentans bioassays, sediments from six locations in the North American Great Lakes were evaluated to see if length of storage at 4-degrees-C had an effect on toxicity over a 112 day period. No statistical difference was observed over this time period. C1 ASCI CORP,DULUTH,MN 55804. USA,ST PAUL DIST CORPS ENGINEERS,ST PAUL,MN 55101. RP OTHOUDT, RA (reprint author), MICHIGAN STATE UNIV,INST ENVIRONM TOXICOL,PESTICIDE RES CTR,DEPT FISHERIES & WILDLIFE,E LANSING,MI 48824, USA. NR 5 TC 14 Z9 14 U1 1 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0045-6535 J9 CHEMOSPHERE JI Chemosphere PY 1991 VL 22 IS 9-10 BP 801 EP 807 DI 10.1016/0045-6535(91)90238-9 PG 7 WC Environmental Sciences SC Environmental Sciences & Ecology GA FW206 UT WOS:A1991FW20600001 ER PT J AU VERBRUGGE, DA OTHOUDT, RA GRZYB, KR HOKE, RA DRAKE, JB GIESY, JP ANDERSON, D AF VERBRUGGE, DA OTHOUDT, RA GRZYB, KR HOKE, RA DRAKE, JB GIESY, JP ANDERSON, D TI CONCENTRATIONS OF INORGANIC AND ORGANIC CONTAMINANTS IN SEDIMENTS OF 6 HARBORS ON THE NORTH-AMERICAN GREAT-LAKES SO CHEMOSPHERE LA English DT Article ID DETROIT RIVER AB Samples of surficial sediments were collected from six different harbors on the North American Great Lakes in May of 1989. Concentrations of 12 metals, 17 pesticides, total PCBs, chlorinated naphthalenes, cyanide and total and unionized ammonia were determined. The sediments were also characterized for moisture content, particle size, total organic carbon content, pH, COD, total solids, total volatile solids. C1 MICHIGAN STATE UNIV,INST ENVIRONM TOXICOL,E LANSING,MI 48824. USA,ST PAUL DIST CORPS ENGINEERS,ST PAUL,MN 55101. RP VERBRUGGE, DA (reprint author), MICHIGAN STATE UNIV,PESTICIDE RES CTR,DEPT FISHERIES & WILDLIFE,E LANSING,MI 48824, USA. RI Hoke, Robert/F-4943-2010 NR 21 TC 9 Z9 9 U1 0 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0045-6535 J9 CHEMOSPHERE JI Chemosphere PY 1991 VL 22 IS 9-10 BP 809 EP 820 DI 10.1016/0045-6535(91)90239-A PG 12 WC Environmental Sciences SC Environmental Sciences & Ecology GA FW206 UT WOS:A1991FW20600002 ER PT J AU DESPIRITO, J KNAPTON, JD AF DESPIRITO, J KNAPTON, JD TI ELECTRICAL IGNITION OF LIQUID PROPELLANT FOR USE IN GUNS SO COMBUSTION SCIENCE AND TECHNOLOGY LA English DT Article RP DESPIRITO, J (reprint author), USA,BALLIST RES LABS,ATTN SLCBR-IB-B,ABERDEEN PROVING GROUND,MD 21005, USA. NR 22 TC 0 Z9 1 U1 0 U2 1 PU GORDON BREACH SCI PUBL LTD PI READING PA C/O STBS LTD PO BOX 90, READING, BERKS, ENGLAND RG1 8JL SN 0010-2202 J9 COMBUST SCI TECHNOL JI Combust. Sci. Technol. PY 1991 VL 76 IS 4-6 BP 251 EP 263 DI 10.1080/00102209108951712 PG 13 WC Thermodynamics; Energy & Fuels; Engineering, Multidisciplinary; Engineering, Chemical SC Thermodynamics; Energy & Fuels; Engineering GA FU459 UT WOS:A1991FU45900005 ER PT J AU CROSIER, RB AF CROSIER, RB TI SYMMETRY IN MIXTURE EXPERIMENTS SO COMMUNICATIONS IN STATISTICS-THEORY AND METHODS LA English DT Article DE BLOCKING; CENTRAL COMPOSITE DESIGN; CENTROID; GEOMETRY; RESPONSE SURFACE DESIGN; ROTATABLE DESIGN; UNIFORM SHELL DESIGN ID DESIGNS; MODELS AB Two types of symmetry can arise when the proportions of mixture components are constrained by upper and lower bounds. These two types of symmetry are shown to be useful for blocking first-order designs, as well as for finding the centroid of the experimental region. Orthogonal blocking of first-order mixture designs provides a method of including process variables in the mixture experiment, with the mixture terms orthogonal to the process factors. Symmetric regions are used to develop spherical and rotatable response surface designs for mixtures. The central composite design and designs based on the icosahedron and the dodecahedron are given for four-component mixtures. The uniform shell designs are three-level designs when applied to mixture experiments. C1 USA,CTR DEV & ENGN,ABERDEEN PROVING GROUND,MD 21010. NR 19 TC 3 Z9 3 U1 0 U2 1 PU MARCEL DEKKER INC PI NEW YORK PA 270 MADISON AVE, NEW YORK, NY 10016 SN 0361-0926 J9 COMMUN STAT THEORY JI Commun. Stat.-Theory Methods PY 1991 VL 20 IS 5-6 BP 1911 EP 1935 DI 10.1080/03610929108830608 PG 25 WC Statistics & Probability SC Mathematics GA GC061 UT WOS:A1991GC06100028 ER PT J AU MAXWELL, DM THOMSEN, RH BASKIN, SI AF MAXWELL, DM THOMSEN, RH BASKIN, SI TI SPECIES-DIFFERENCES IN THE NEGATIVE INOTROPIC EFFECT OF ACETYLCHOLINE AND SOMAN IN RAT, GUINEA-PIG, AND RABBIT HEARTS SO COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY LA English DT Article ID MUSCARINIC CHOLINERGIC RECEPTORS; HIGH-AFFINITY; INHIBITION; ADENOSINE; MECHANISM AB 1. Acetylcholine reduced atrial contractions by 82.5% in guinea pig, 50.8% in rat, and 41.5% in rabbit. 2. The EC50 values for the negative inotropic effect of acetylcholine were 3.3 x 10(-7) M in rat and guinea pig atria and 4.1 x 10(-6) M in rabbit atria. 3. There was no correlation between the species differences in the negative inotropic effect of acetylcholine in atria and the density or affinity of acetylcholinesterase or muscarinic receptors. 4. Inhibition of atrial acetylcholinesterase with soman reduced the EC50 of acetylcholine three-fold in all species, but did not change the maximal inotropic effect of acetylcholine. 5. Species differences in the negative inotropic effect of acetylcholine may be caused by differences in the coupling between myocardial muscarinic receptors and the ion channels that mediate negative inotropy. RP MAXWELL, DM (reprint author), USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010, USA. NR 37 TC 4 Z9 4 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0742-8413 J9 COMP BIOCHEM PHYS C JI Comp. Biochem. Physiol. C-Pharmacol. Toxicol. Endocrinol. PY 1991 VL 100 IS 3 BP 591 EP 595 DI 10.1016/0742-8413(91)90045-U PG 5 WC Biochemistry & Molecular Biology; Endocrinology & Metabolism; Toxicology; Zoology SC Biochemistry & Molecular Biology; Endocrinology & Metabolism; Toxicology; Zoology GA GU724 UT WOS:A1991GU72400044 PM 1687557 ER PT J AU LESKOVAC, V THEOHARIDES, AD AF LESKOVAC, V THEOHARIDES, AD TI HEPATIC-METABOLISM OF ARTEMISININ DRUGS .1. DRUG-METABOLISM IN RAT-LIVER MICROSOMES SO COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY LA English DT Article ID QINGHAOSU ARTEMISININ; ANTIMALARIAL DRUG; DIHYDROQINGHAOSU; DERIVATIVES; CHEMISTRY AB 1. In this communication, metabolism of the semisynthetic antimalarial drugs of the artemisinin class (beta-arteether, beta-artelinic acid and dihydroartemisinin) in rat liver microsomes, is reported. 2. Dihydroartemisinin was the major early metabolite of arteether (57%) and artelinic acid (80%); in addition, arteether was hydroxylated in the positions 9-alpha- and 2-alpha- of the molecule. 3. Dihydroartemisinin was further metabolized by extensive hydroxylation of its molecule; we were able to identify four hydroxylated derivatives of DQHS, but not the exact positions of the hydroxyl groups. 4. The rates of NADPH-supported metabolism of arteether, artelinic acid and dihydroartemisinin in rat liver microsomes were: 4.0, 2.5 and 1.3 nmol/min/mg of microsomal protein, respectively. 5. The apparent affinity constants of arteether and artelinic acid for the microsomal metabolizing system, calculated from the rates of product formation, were 0.54 mM and 0.33 mM (for arteether) and 0.11 mM (for artelinic acid), respectively. The appearance of two affinity constants indicated that arteether was metabolized by two different isoenzymes of cytochrome P-450 in rat liver microsomes. C1 WALTER REED ARMY MED CTR,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307. NR 17 TC 50 Z9 51 U1 0 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0742-8413 J9 COMP BIOCHEM PHYS C JI Comp. Biochem. Physiol. C-Pharmacol. Toxicol. Endocrinol. PY 1991 VL 99 IS 3 BP 383 EP 390 DI 10.1016/0742-8413(91)90261-Q PG 8 WC Biochemistry & Molecular Biology; Endocrinology & Metabolism; Toxicology; Zoology SC Biochemistry & Molecular Biology; Endocrinology & Metabolism; Toxicology; Zoology GA GA846 UT WOS:A1991GA84600024 PM 1685412 ER PT J AU LESKOVAC, V THEOHARIDES, AD AF LESKOVAC, V THEOHARIDES, AD TI HEPATIC-METABOLISM OF ARTEMISININ DRUGS .2. METABOLISM OF ARTEETHER IN RAT-LIVER CYTOSOL SO COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY LA English DT Article ID QINGHAOSU ARTEMISININ; ANTIMALARIAL DRUG AB 1. In this communication, in vitro metabolism of a semisynthetic antimalarial drug arteether in rat liver cytosol is reported. 2. Whenever C-14-labeled arteether was mixed with rat liver cytosol, a crude postmicrosomal fraction of liver cell homogenates, an appearance of three major C-14-labeled metabolites was always attested: deoxy-dihydroartemisinin, AEM-1 (Baker et al., 1988) and metabolite MW286. 3. Transformation of arteether into deoxyDQHS was catalyzed by an enzyme present in the rat liver cytosol, whose activity depended on the presence of NAD+/NADH and a low molecular, dialyzable factor present in the cytosol. The maximal activity of this enzyme was 0.31 nmol of deoxyDQHS formed/min/mg of cytosolic protein. 4. AEM-1 and metabolite mol. wt 286 have been formed directly from arteether by a chemical interaction of the drug with the cytosolic fraction, probably in a non-enzymatic reaction. 5. Taking together the in vitro data of arteether metabolism in rat liver cytosol, presented in this communication, and in vitro data in rat liver microsomes, presented in the preceding communication (Leskovac and Theoharides, 1991), we were able to postulate an integral pathway of Phase I metabolism of arteether in a whole rat liver cell. C1 WALTER REED ARMY MED CTR,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307. NR 11 TC 43 Z9 43 U1 0 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0742-8413 J9 COMP BIOCHEM PHYS C JI Comp. Biochem. Physiol. C-Pharmacol. Toxicol. Endocrinol. PY 1991 VL 99 IS 3 BP 391 EP 396 DI 10.1016/0742-8413(91)90262-R PG 6 WC Biochemistry & Molecular Biology; Endocrinology & Metabolism; Toxicology; Zoology SC Biochemistry & Molecular Biology; Endocrinology & Metabolism; Toxicology; Zoology GA GA846 UT WOS:A1991GA84600025 PM 1685413 ER PT J AU ULIN, RR YOUNG, TD AF ULIN, RR YOUNG, TD TI CONVENTIONAL ARMS-CONTROL AND DISARMAMENT - LESSONS FROM THE INTERWAR PERIOD SO COMPARATIVE STRATEGY LA English DT Article RP ULIN, RR (reprint author), USA,WAR COLL,INST STRATEG STUDIES,CARLISLE,PA 17013, USA. NR 20 TC 0 Z9 0 U1 0 U2 0 PU TAYLOR & FRANCIS PI BRISTOL PA 1900 FROST ROAD, SUITE 101, BRISTOL, PA 19007-1598 SN 0149-5933 J9 COMP STRATEGY PY 1991 VL 10 IS 3 BP 205 EP 215 DI 10.1080/01495939108402844 PG 11 WC International Relations; Political Science SC International Relations; Government & Law GA FX175 UT WOS:A1991FX17500001 ER PT J AU GHIORSE, SR JURTA, RM AF GHIORSE, SR JURTA, RM TI EFFECTS OF LOW-FREQUENCY VIBRATION PROCESSING ON CARBON EPOXY LAMINATES SO COMPOSITES LA English DT Article DE COMPOSITE MATERIALS; PROCESSING; VACUUM BAGGING; VIBRATION ASSISTANCE; VOID CONTENT; LAMINATE DENSITY; CARBON FIBERS; EPOXY RESIN AB Low frequency vibration was applied during the pre-gellation period of the cure cycle of vacuum-bagged carbon/epoxy unidirectional tape, (0/90)4s laminated plates. Decreased void content in excess of 50% and increased laminate densification of 0.5% were measured. Data also indicated an approximate 10% increase in size of the remaining voids. C1 USA,MAT TECHNOL LAB,MAT SCI BRANCH,WATERTOWN,MA 02172. RP GHIORSE, SR (reprint author), USA,MAT TECHNOL LAB,COMPOSITES DEV BRANCH,WATERTOWN,MA 02172, USA. NR 10 TC 9 Z9 9 U1 0 U2 3 PU BUTTERWORTH-HEINEMANN LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB SN 0010-4361 J9 COMPOSITES JI Composites PD JAN PY 1991 VL 22 IS 1 BP 3 EP 8 DI 10.1016/0010-4361(91)90097-Z PG 6 WC Materials Science, Composites SC Materials Science GA EZ080 UT WOS:A1991EZ08000001 ER PT J AU TESSLER, A AF TESSLER, A TI A HIGHER-ORDER PLATE-THEORY WITH IDEAL FINITE-ELEMENT SUITABILITY SO COMPUTER METHODS IN APPLIED MECHANICS AND ENGINEERING LA English DT Article ID REFINED THEORY; SHEAR AB A variational tenth-order theory for stretching and bending of orthotropic elastic plates is proposed which lends itself perfectly to finite element formulations based upon C-0 and C-1-continuous displacement approximations. The deformations due to all strain and stress components are accounted. The theory is derived from three-dimensional elasticity via a modified virtual work statement based upon independent displacement and transverse strain expansions through the thickness. The transverse displacement employs a special parabolic form while the in-plane displacements are taken to be linear. The issues of thickness-expansion related inconsistencies in the transverse shear strains and the transverse normal stress are resolved by the enforcement of physical stress boundary conditions and variationally consistent 'weak' transverse strain compatibility. The resulting transverse shear strains are parabolic, while the transverse normal strain varies cubically across the plate thickness. The variational principle yields seven equations of motion and exclusively Poisson-type edge boundary conditions. A qualitative assessment of the theory is carried out for the problem of static equilibrium involving an infinite plate under a sinusoidal normal pressure. A simple three-node plate element is then developed comparable in computational efficiency to its Mindlin-theory counterpart but which enables accurate computation of all displacement, strain and stress components for a wide range of the plate span-to-thickness ratio. RP TESSLER, A (reprint author), USA, MAT TECHNOL LAB, MECH & STRUCT BRANCH, WATERTOWN, MA 02172 USA. RI Tessler, Alexander/A-4729-2009 NR 25 TC 18 Z9 18 U1 0 U2 1 PU ELSEVIER SCIENCE SA PI LAUSANNE PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND SN 0045-7825 EI 1879-2138 J9 COMPUT METHOD APPL M JI Comput. Meth. Appl. Mech. Eng. PD JAN PY 1991 VL 85 IS 2 BP 183 EP 205 DI 10.1016/0045-7825(91)90132-P PG 23 WC Engineering, Multidisciplinary; Mathematics, Interdisciplinary Applications; Mechanics SC Engineering; Mathematics; Mechanics GA EX180 UT WOS:A1991EX18000003 ER PT J AU RICHARDSON, JD WHEELER, TJ AF RICHARDSON, JD WHEELER, TJ TI A 2-LAYERED INTERFACE ARCHITECTURE SO COMPUTER STANDARDS & INTERFACES LA English DT Article DE DATABASES; DATABASE MANAGEMENT SYSTEMS; DATA MODELS; INTERFACES; LANGUAGES; OBJECT-ORIENTED AB The problems of interfacing to external subsystems and using multiple paradigms in a single software system center on resolving the impedance mismatch (the differences in the data models and thought patterns of each paradigm) and how to reflect the differences across the language boundary. One technique is to build an interface between the two paradigms. The interface should strive to resolve the mismatches while providing access to those language features valuable to the problem solution. This means that semantic issues as well as syntactic issues must be addressed. Features of the implementation languages that contribute to the mismatch need to be identified and examined in order to develop a solution. This paper describes a two-layer architecture based upon the idea of abstract interfaces. This architecture appears to provide a basis for interfacing programming languages to object databases which addresses the semantic gap, or impedance mismatch, between the two as well as the syntactic differences. C1 MONMOUTH COLL,USA,CECOM,CTR SOFTWARE ENGN,CS DEPT,SOFTWARE ENGN RES GRP,LONG BRANCH,NJ 07764. NR 10 TC 0 Z9 0 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0920-5489 J9 COMP STAND INTER JI Comput. Stand. Interfaces PY 1991 VL 13 IS 1-3 BP 151 EP 154 DI 10.1016/0920-5489(91)90023-S PG 4 WC Computer Science, Hardware & Architecture; Computer Science, Software Engineering SC Computer Science GA GL214 UT WOS:A1991GL21400022 ER PT J AU HAN, SY KIM, THJ ADIGUZEL, I AF HAN, SY KIM, THJ ADIGUZEL, I TI INTEGRATION OF PROGRAMMING-MODELS AND EXPERT SYSTEMS - AN APPLICATION TO FACILITY PLANNING AND MANAGEMENT SO COMPUTERS ENVIRONMENT AND URBAN SYSTEMS LA English DT Article ID OPERATIONAL-RESEARCH AB The purpose of this paper is to examine possible benefits of combining mathematical programming models and expert systems. This paper discusses the relationship between operations research, decision support systems and expert systems. To demonstrate the feasibility of coupling expert systems with other existing computer techniques, this paper also discusses the design and development of an automated computer system, XPlanner. XPlanner is a knowledge-based decision support system which integrates an expert system with an integer optimization model and a database management system. XPlanner is developed to aid decision making in the area of facility planning management. C1 UNIV ILLINOIS,DEPT URBAN & REG PLANNING,URBANA,IL 61801. KYUNG HEE UNIV,SEOUL,SOUTH KOREA. USA,CORPS ENGINEERS,CONSTRUCT ENGN RES LAB,WASHINGTON,DC 20310. NR 16 TC 2 Z9 2 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0198-9715 J9 COMPUT ENVIRON URBAN JI Comput. Environ. Urban Syst. PY 1991 VL 15 IS 3 BP 189 EP 201 DI 10.1016/0198-9715(91)90008-2 PG 13 WC Computer Science, Interdisciplinary Applications; Engineering, Environmental; Environmental Studies; Geography; Operations Research & Management Science SC Computer Science; Engineering; Environmental Sciences & Ecology; Geography; Operations Research & Management Science GA GQ921 UT WOS:A1991GQ92100008 ER PT J AU ROBERTSON, JS SIEGMANN, WL JACOBSON, MJ AF ROBERTSON, JS SIEGMANN, WL JACOBSON, MJ TI OS21FD - A MICROCOMPUTER IMPLEMENTATION OF THE PARABOLIC EQUATION FOR PREDICTING UNDERWATER SOUND-PROPAGATION SO COMPUTERS & GEOSCIENCES LA English DT Article DE OCEAN ACOUSTICS; SOUND PROPAGATION; NUMERICAL MODELING; PARABOLIC APPROXIMATION; FINITE DIFFERENCES AB Underwater acoustic signals are powerful scientific tools for probing large regions of the ocean which would otherwise be inaccessible. Oceanographers and other scientists use acoustic energy as a mechanism to examine the structure of ocean regions for a variety of purposes. Predicting the behavior of sound in different types of ocean environments is an extraordinarily difficult problem which has been studied intensely for many decades. The parabolic approximation, introduced to the oceanographic community more than a decade ago has proven to be a powerful and effective ocean acoustics propagation model. Whereas these models were once exclusively run on mainframe computers, the advent of fast microcomputer chips, together with operating systems that can exploit the powerful features of these chips, now makes personal computers an attractive tool for performing many propagation prediction computations. This paper describes a full-featured version of one such widely used underwater acoustic propagation model which runs on PCs under the OS/2 operating system. C1 RENSSELAER POLYTECH INST,DEPT MATH SCI,TROY,NY 12180. RP ROBERTSON, JS (reprint author), US MIL ACAD,DEPT MATH SCI,W POINT,NY 10996, USA. NR 5 TC 2 Z9 2 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0098-3004 J9 COMPUT GEOSCI JI Comput. Geosci. PY 1991 VL 17 IS 6 BP 731 EP 757 DI 10.1016/0098-3004(91)90058-L PG 27 WC Computer Science, Interdisciplinary Applications; Geosciences, Multidisciplinary SC Computer Science; Geology GA GB192 UT WOS:A1991GB19200001 ER PT J AU SHIEH, LS ZHANG, JL COLEMAN, NP AF SHIEH, LS ZHANG, JL COLEMAN, NP TI OPTIMAL DIGITAL REDESIGN OF CONTINUOUS-TIME CONTROLLERS SO COMPUTERS & MATHEMATICS WITH APPLICATIONS LA English DT Article AB This paper proposes a new optimal digital redesign technique for finding a dynamic digital control law from the available analog counterpart and simultaneously minimizing a quadratic performance index. The proposed technique can be applied to a system with a more general class of reference inputs, and the developed digital regulator can be implemented using low cost microcomputers. C1 USA,CTR ARMAMENT,DOVER,NJ 07806. RP SHIEH, LS (reprint author), UNIV HOUSTON,DEPT ELECT ENGN,UNIV PK,HOUSTON,TX 77204, USA. NR 9 TC 16 Z9 16 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0898-1221 J9 COMPUT MATH APPL JI Comput. Math. Appl. PY 1991 VL 22 IS 1 BP 25 EP 35 DI 10.1016/0898-1221(91)90022-V PG 11 WC Mathematics, Applied SC Mathematics GA FP845 UT WOS:A1991FP84500003 ER PT J AU ECHEVERRY, D IBBS, CW KIM, S AF ECHEVERRY, D IBBS, CW KIM, S TI A KNOWLEDGE-BASED APPROACH TO SUPPORT THE GENERATION OF CONSTRUCTION SCHEDULES SO COMPUTERS & STRUCTURES LA English DT Article; Proceedings Paper CT 1ST INTERNATIONAL CONF ON THE APPLICATION OF ARTIFICIAL INTELLIGENCE TECHNIQUES TO CIVIL AND STRUCTURAL ENGINEERING ( CIVIL-COMP 89 ) CY SEP 20-22, 1989 CL CITY UNIV, LONDON, ENGLAND HO CITY UNIV AB Computerized support of the task of generating construction schedules is currently limited to provide a network representation of activities manually defined and sequenced. This definition of the activities, their characteristics (resource allocation, duration, etc.), and their sequencing demands substantial expertise and is time consuming. This research work attempts to provide intelligent support to the construction scheduler. A Knowledge-Based Systems approach is used, which involves three major phases: (1) knowledge acquisition from experts; (2) formalization of the elicited knowledge; and (3) production of a prototype Knowledge-Based System. An extensive program of interaction with industry expert schedulers is described here. The status of the computer implementation work is discussed as well. C1 UNIV CALIF BERKELEY,DEPT CIVIL ENGN,BERKELEY,CA 94720. USA,CERL,CHAMPAIGN,IL. RP ECHEVERRY, D (reprint author), UNIV ILLINOIS,DEPT CIVIL ENGN,URBANA,IL 61801, USA. NR 9 TC 1 Z9 1 U1 0 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0045-7949 J9 COMPUT STRUCT JI Comput. Struct. PY 1991 VL 40 IS 1 BP 59 EP 66 DI 10.1016/0045-7949(91)90457-W PG 8 WC Computer Science, Interdisciplinary Applications; Engineering, Civil SC Computer Science; Engineering GA FW313 UT WOS:A1991FW31300010 ER PT J AU SANTIAGO, JM BHATTACHARYA, S AF SANTIAGO, JM BHATTACHARYA, S TI SENSITIVITY OF PLATE RESPONSE CALCULATIONS TO BLAST LOAD DEFINITION SO COMPUTERS & STRUCTURES LA English DT Article; Proceedings Paper CT 8TH ADINA CONF ( AUTOMATIC DYNAMIC INCREMENTAL NONLINEAR ANALYSIS ) CY JUL 17-19, 1991 CL MIT, CAMBRIDGE, MA HO MIT AB The ADINA program has been used with three progressively more accurate loading functions to model the dynamic response of a plate. The calculations simulated the response of a 19 mm thick aluminum plate, clamped over a circular opening 914 mm in diameter, subjected to the blast from an explosive charge suspended 645 mm over its center. The loading functions were based on prior hydrocode calculations of the detonation flow using successively refined computational grids. The influence of clamped edge conditions on the response was bracketed by allowing no sliding and frictionless sliding. Calculations were performed using a linear analysis, a material nonlinear analysis with kinematic hardening plasticity, and a combined material and geometric nonlinear analysis. The deflection histories obtained with the three methods of analysis using the three progressively refined loading functions for the two bracketing boundary conditions were compared. The response was found to be sensitive principally to the total impulse delivered to the plate, though the influence of loading details was detected. Despite a significant amount of plasticity, the deflections were predominantly influenced by the strong coupling between the membrane and transverse deformations, resulting in the response being noticeably affected by boundary modeling and indicating a need to use the geometric nonlinear method of analysis. RP SANTIAGO, JM (reprint author), USA,BALLIST RES LABS,ABERDEEN PROVING GROUND,MD 21005, USA. NR 5 TC 1 Z9 1 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0045-7949 J9 COMPUT STRUCT JI Comput. Struct. PY 1991 VL 40 IS 2 BP 375 EP 392 DI 10.1016/0045-7949(91)90363-Q PG 18 WC Computer Science, Interdisciplinary Applications; Engineering, Civil SC Computer Science; Engineering GA FW554 UT WOS:A1991FW55400019 ER PT J AU ALVING, CR SWARTZ, GM AF ALVING, CR SWARTZ, GM TI ANTIBODIES TO CHOLESTEROL, CHOLESTEROL CONJUGATES, AND LIPOSOMES - IMPLICATIONS FOR ATHEROSCLEROSIS AND AUTOIMMUNITY SO CRITICAL REVIEWS IN IMMUNOLOGY LA English DT Article ID C5B-9 COMPLEMENT COMPLEX; MONOCLONAL-ANTIBODIES; LIPID-A; CRYSTALLINE CHOLESTEROL; MODEL MEMBRANES; SPECIFICITY; PROGESTERONE; PHOSPHATIDYLCHOLINE; AUTOANTIBODIES; TESTOSTERONE AB Polyclonal and monoclonal antibodies to cholesterol are readily induced by injecting cholesterol-loaded liposomes containing lipid A as an adjuvant. Analysis of the literature reveals that conjugates of cholesterol, and conjugates of analogues of cholesterol, with heterologous proteins or lipids have been used as antigens in various studies since 1925, and this has led to successful development of immunoassays for steroid hormones. It is concluded that cholesterol is a highly immunogenic molecule. The ability of monoclonal antibodies to cholesterol to react with liposomes containing cholesterol to cause complement-dependent immune damage to the liposomes is strongly influenced by the lipid composition of the liposomes, the amount of cholesterol in the liposomes, and the reaction temperature. The antibodies also react with crystalline cholesterol in a solid-phase ELISA and, depending on the particular monoclonal antibody, immune reactivity may or may not be observed with cholesterol esters, cholesterol analogues, or steroid hormones. Analysis by ELISA has revealed that virtually all normal human sera contain varying levels of naturally occurring IgG and IgM autoantibodies to cholesterol. Naturally occurring autoantibodies to cholesterol are also observed in pigs, but not in guinea pigs. Possible implications of these investigations for theories of immune mechanisms that may have beneficial or detrimental roles in processes of aging, atherosclerosis, and vascular diseases are discussed. RP ALVING, CR (reprint author), WALTER REED ARMY MED CTR,DEPT MEMBRANE BIOCHEM,WASHINGTON,DC 20307, USA. NR 90 TC 71 Z9 71 U1 1 U2 1 PU BEGELL HOUSE INC PI NEW YORK PA 79 MADISON AVE, SUITE 1205, NEW YORK, NY 10016-7892 SN 1040-8401 J9 CRIT REV IMMUNOL JI Crit. Rev. Immunol. PY 1991 VL 10 IS 5 BP 441 EP 453 PG 13 WC Immunology SC Immunology GA EV442 UT WOS:A1991EV44200004 PM 2021426 ER PT J AU ELLIOTT, RM SCHMALJOHN, CS COLLETT, MS AF ELLIOTT, RM SCHMALJOHN, CS COLLETT, MS TI BUNYAVIRIDAE GENOME STRUCTURE AND GENE-EXPRESSION SO CURRENT TOPICS IN MICROBIOLOGY AND IMMUNOLOGY LA English DT Article ID VALLEY FEVER VIRUS; SNOWSHOE HARE BUNYAVIRUS; S-RNA SEGMENT; NUCLEOTIDE-SEQUENCE ANALYSIS; SPOTTED WILT VIRUS; RENAL SYNDROME HFRS; PUNTA TORO VIRUS; MESSENGER-RNA; UUKUNIEMI VIRUS; HANTAAN VIRUS C1 MEDIMMUNE INC, GAITHERSBURG, MD 20878 USA. USA, MED RES INST INFECT DIS, DIV VIROL, FREDERICK, MD 21701 USA. RP ELLIOTT, RM (reprint author), UNIV GLASGOW, INST VIROL, CHURCH ST, GLASGOW G11 5JR, SCOTLAND. NR 142 TC 132 Z9 145 U1 4 U2 9 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0070-217X J9 CURR TOP MICROBIOL JI Curr. Top. Microbiol. Immunol. PY 1991 VL 169 BP 91 EP 141 PG 51 WC Immunology; Microbiology SC Immunology; Microbiology GA FZ790 UT WOS:A1991FZ79000004 PM 1935231 ER PT J AU KELLY, M SIEGEL, MA BALCIUNAS, BA KONZELMAN, JL AF KELLY, M SIEGEL, MA BALCIUNAS, BA KONZELMAN, JL TI ORAL MANIFESTATIONS OF HUMAN-IMMUNODEFICIENCY-VIRUS INFECTION SO CUTIS LA English DT Article ID EPSTEIN-BARR VIRUS; HAIRY LEUKOPLAKIA; AIDS AB Oral candidiasis, herpetic lesions, oral mucosal warts, human immunodeficiency virus-associated gingivitis and periodontitis, Kaposi's sarcoma, hairy leukoplakia, and non-Hodgkin's lymphoma are oral manifestations of infection by the human immunodeficiency virus. This paper will explain how to identify these lesions, their significance, and recommended treatments. C1 WALTER REED ARMY MED CTR,JACKSON FDN,HIV PROGRAM,WASHINGTON,DC 20307. RP KELLY, M (reprint author), UNIV MARYLAND,SCH DENT,DEPT ORAL MED & DIAGNOST SCI,666 W BALTIMORE ST,BALTIMORE,MD 21201, USA. NR 16 TC 0 Z9 0 U1 0 U2 0 PU EXCERPTA MEDICA INC PI NEW YORK PA 245 WEST 17TH STREET, NEW YORK, NY 10011 SN 0011-4162 J9 CUTIS JI Cutis PD JAN PY 1991 VL 47 IS 1 BP 44 EP 49 PG 6 WC Dermatology SC Dermatology GA ER606 UT WOS:A1991ER60600006 PM 1993402 ER PT J AU ANDERSON, DR HARRIS, LW LENNOX, WJ SOLANA, RP AF ANDERSON, DR HARRIS, LW LENNOX, WJ SOLANA, RP TI EFFECTS OF SUBACUTE PRETREATMENT WITH CARBAMATE TOGETHER WITH ACUTE ADJUNCT PRETREATMENT AGAINST NERVE AGENT EXPOSURE SO DRUG AND CHEMICAL TOXICOLOGY LA English DT Article ID SOMAN; PYRIDOSTIGMINE; PROTECTION; CHOLINESTERASE; PHYSOSTIGMINE; ACETYLCHOLINE; RATS AB Visual observations were made to compare the pretreatment benefits of subacute (75-mu-g/hr, sc) and acute (146-mu-g/kg, im, at 30 min) deliveries of physostigmine salicylate (Phy) against 2 or 5 LD50s (60 or 150-mu-g/kg, sc) of soman in guinea pigs; scopolamine, 80-mu-g/kg, im, was given routinely at 30 min. In a second set of studies, pretreatment with subacute carbamate [sc, Phy 36-mu-g/hr or pyridostigmine (Pyr), 50-mu-g/hr] and acute adjunct (im, scopolamine, 0.48 mg/kg, or trihexyphenidyl, 2 mg/kg) at 30 min, was used against soman (5 LD50s, sc) and VX (18.4-mu-g/kg, sc; 2 LD50s); atropine (16 mg/kg, im) and 2-PAM (25 mg/kg, im) were given at 1 min post soman. In all studies, lethality, % convulsing, convulsive/subconvulsive score, and recovery time were noted. Subacute dosing for 7 days was done via 14-day osmotic minipumps (OMPs). Results of the first set of studies indicate that subacute and acute deliveries of Phy give essentially comparable protection against 2 or 5 LD50s of soman. The second set of studies show that against soman, the adjuncts scopolamine and trihexyphenidyl when compared, and the carbamates, Phy and Pyr when compared, gave similar protective benefits as indicated by all four monitored measures of toxicity. Phy with either adjunct provided excellent protection against VX induced mortality and convulsions. With both carbamates, trihexyphenidyl gave similar protective benefits against VX. Scopolamine, however, under the conditions used herein, failed to act beneficially with Pyr against VX. RP ANDERSON, DR (reprint author), USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010, USA. NR 16 TC 12 Z9 12 U1 0 U2 0 PU MARCEL DEKKER INC PI NEW YORK PA 270 MADISON AVE, NEW YORK, NY 10016 SN 0148-0545 J9 DRUG CHEM TOXICOL JI Drug Chem. Toxicol. PY 1991 VL 14 IS 1-2 BP 1 EP 19 DI 10.3109/01480549109017866 PG 19 WC Chemistry, Multidisciplinary; Pharmacology & Pharmacy; Toxicology SC Chemistry; Pharmacology & Pharmacy; Toxicology GA FV876 UT WOS:A1991FV87600001 PM 1889370 ER PT J AU ROMANO, JA TERRY, MR MURROW, ML MAYS, MZ AF ROMANO, JA TERRY, MR MURROW, ML MAYS, MZ TI PROTECTION FROM LETHALITY AND BEHAVIORAL INCAPACITATION RESULTING FROM INTOXICATION BY SOMAN (PINACOLYL METHYLPHOSPHONO FLUORIDATE) AND TREATMENT WITH ATROPINE SULFATE AND 2-PAM CHLORIDE IN THE GUINEA-PIG, CAVIA-PORCELLUS SO DRUG AND CHEMICAL TOXICOLOGY LA English DT Article ID PHYSOSTIGMINE; PRETREATMENT; RATS AB The lethal and incapacitating effects of the toxic organophosphorus (OP) agent, soman were evaluated in guinea pigs. The protective effects of the standard therapies atropine sulfate (ATR) and pralidoxime chloride (2-PAM) in minimizing or reducing soman-produced lethality and incapacitation (evaluated using a modification of the rat conditioned avoidance procedure) were also studied. At 0.75 and 1.5 LD50 soman was extremely toxic and fast-acting; its effects appeared within five minutes, and its lethal effects occurred within the first three hours. Therapeutic combinations of ATR (64 or 128 mg/kg) and 2-PAM (25 or 100 mg/kg) protected animals from the lethality of soman, but not from its incapacitating effects. However, therapeutic treatment with ATR and 2-PAM also produced a behavioral toxicity in its own right, an effect which lasted for at least three hours in the guinea pig. This behavioral toxicity was lessened by reducing ATR dosage from 128 to 64 mg/kg, but 2-PAM dosage did not influence the behavioral toxicity of the treatment combinations within the range of dosages studied. RP ROMANO, JA (reprint author), USA,MED RES INST CHEM DEF,DIV DRUG ASSESSMENT,ABERDEEN PROVING GROUND,MD 21010, USA. NR 26 TC 7 Z9 7 U1 0 U2 1 PU MARCEL DEKKER INC PI NEW YORK PA 270 MADISON AVE, NEW YORK, NY 10016 SN 0148-0545 J9 DRUG CHEM TOXICOL JI Drug Chem. Toxicol. PY 1991 VL 14 IS 1-2 BP 21 EP 44 DI 10.3109/01480549109017867 PG 24 WC Chemistry, Multidisciplinary; Pharmacology & Pharmacy; Toxicology SC Chemistry; Pharmacology & Pharmacy; Toxicology GA FV876 UT WOS:A1991FV87600002 PM 1889376 ER PT J AU ROBINSON, M BERCZ, JP RINGHAND, HP CONDIE, LW PARNELL, MJ AF ROBINSON, M BERCZ, JP RINGHAND, HP CONDIE, LW PARNELL, MJ TI 10-DAY AND 90-DAY TOXICITY STUDIES OF 1,2-DICHLOROBENZENE ADMINISTERED BY ORAL GAVAGE TO SPRAGUE-DAWLEY RATS SO DRUG AND CHEMICAL TOXICOLOGY LA English DT Article AB Ten- and ninety-day toxicity studies of 1,2-dichlorobenzene (DCB) were conducted in male and female Sprague-Dawley rats to meet the needs of the U.S. Environmental Protection Agency for toxicity data on this chemical for use in their determination of possible health risks related to human exposure. 1,2-Dichlorobenzene was administered at doses of 37.5, 75, 150, and 300 mg/kg/day (10-day), and 25, 100, and 400 mg/kg/day (90-day) in corn oil by oral gavage; control animals received corn oil. At time of sacrifice, gross necropsies were performed and selected tissues were weighed and prepared for histological evaluation. Blood was taken for hematology and clinical chemistries. In the 10-day study, exposure of 300 mg DCB/kg body weight to male rats resulted in a statistically significant decrease in final body weight, organ weights (heart, kidneys, spleen, testes, and thymus), and relative organ weights (spleen and thymus). A significant increase in absolute and relative liver weights was also noted in this dose group. Males also displayed significant increases in water consumption (300 mg/kg group), ALT (300 mg/kg) and leukocyte count (150 and 300 mg/kg). A significant increase in the incidence of hepatocellular necrosis was seen in the 300 mg/kg group of males compared to controls. In the 90-day study, male rats exposed to 400 mg DCB/kg displayed a statistically significant decrease in body weight, organ weight (spleen), and relative organ weight (spleen). The absolute weights of kidney and liver and the relative weights for heart, kidney, liver, lung, brain, and testes were increased significantly for this dose group. The absolute and relative weights of both the kidney and liver were significantly increased in the female 400 mg/kg dose group. The only clinical chemistry parameters statistically different than control were increased ALT (100 and 400 mg/kg groups), BUN and total bilirubin in the male 400 mg/kg group and total bilirubin in the 400 mg/kg female group. Histopathological evaluation showed hepatocellular lesions associated with DCB treatment which included centrolobular degeneration and hypertrophy, and single cell necrosis in male and females receiving 400 mg DCB/kg. The NOAEL observed in this study is 25 mg/kg/day. C1 USA,DUGWAY PROVING GROUND,DUGWAY PROVING GROUND,UT 84022. USAF,AEROSP MED RES LAB,WRIGHT PATTERSON AFB,OH 45433. RP ROBINSON, M (reprint author), US EPA,HLTH EFFECTS RES LAB,DIV ENVIRONM TOXICOL,26 W MARTIN LUTHER KING DR,CINCINNATI,OH 45268, USA. NR 16 TC 9 Z9 10 U1 1 U2 1 PU MARCEL DEKKER INC PI NEW YORK PA 270 MADISON AVE, NEW YORK, NY 10016 SN 0148-0545 J9 DRUG CHEM TOXICOL JI Drug Chem. Toxicol. PY 1991 VL 14 IS 1-2 BP 83 EP 112 DI 10.3109/01480549109017870 PG 30 WC Chemistry, Multidisciplinary; Pharmacology & Pharmacy; Toxicology SC Chemistry; Pharmacology & Pharmacy; Toxicology GA FV876 UT WOS:A1991FV87600005 PM 1889379 ER PT J AU HARRIS, LW TALBOT, BG LENNOX, WJ ANDERSON, DR SOLANA, RP AF HARRIS, LW TALBOT, BG LENNOX, WJ ANDERSON, DR SOLANA, RP TI PHYSOSTIGMINE (ALONE AND TOGETHER WITH ADJUNCT) PRETREATMENT AGAINST SOMAN, SARIN, TABUN AND VX INTOXICATION SO DRUG AND CHEMICAL TOXICOLOGY LA English DT Article ID BRAIN ACETYLCHOLINE; PROTECTION; ATROPINE; RATS; CHOLINESTERASE; SCOPOLAMINE; AGENTS AB A pretreatment for organophosphorus (OP) anticholinesterase (e.g., soman) intoxication should prevent lethality and convulsions (CNV) at 2 LD50s and be behavioral-decrement-free when given alone. Behavioral-deficit-free pretreatment regimens (PRGs) for guinea pigs consisted of Physostigmine (0.15 mg/kg, im) and adjunct. Adjuncts [mg/kg, im] tested were akineton [0.25], aprophen [8], trihexyphenidyl [2], atropine [16], azaprophen [5], benactyzine [1.25], cogentin [4], dextromethorphan [7.5], ethopropazine [12], kemadrin [1], memantine [5], promethazine [5], scopolamine [0.08] and vontrol [2]. PRGs were given 30 min before soman (60 ug/kg, sc; 2 LD50s) or other OP agents. Animals were then observed and graded for signs of intoxication, including CNV at 7 time points and at 24 hr. Physostigmine alone reduced the incidence of CNV and lethality induced by 2 LD50s of soman by 42 and 60%, respectively. All of the PRGs tested abolished lethality and 12 shortened recovery time to 2 hr or less. Also, PRGs including azaprophen or atropine prevented CNV. When selected PRGs were tested against intoxication by sarin, tabun or VX, the efficacy was generally superior to that for soman. The data show that several PRGs are effective against soman intoxication in guinea pigs. RP HARRIS, LW (reprint author), USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010, USA. NR 30 TC 28 Z9 29 U1 0 U2 1 PU MARCEL DEKKER INC PI NEW YORK PA 270 MADISON AVE, NEW YORK, NY 10016 SN 0148-0545 J9 DRUG CHEM TOXICOL JI Drug Chem. Toxicol. PY 1991 VL 14 IS 3 BP 265 EP 281 DI 10.3109/01480549109002189 PG 17 WC Chemistry, Multidisciplinary; Pharmacology & Pharmacy; Toxicology SC Chemistry; Pharmacology & Pharmacy; Toxicology GA GC059 UT WOS:A1991GC05900004 PM 1935706 ER PT J AU MOORE, DH WALL, HG AF MOORE, DH WALL, HG TI THE EFFECTS OF EXERCISE FOLLOWING EXPOSURE TO BIS(TRIFLUOROMETHYL) DISULFIDE SO DRUG AND CHEMICAL TOXICOLOGY LA English DT Article ID POLYTETRAFLUOROETHYLENE PTFE; INHALATION; TOXICITY; PRODUCTS; RATS AB Bis(trifluoromethyl) disulfide (TFD) was originally designed for use as an agricultural fumigant. Inhalation of toxic doses of TFD results in varying degrees of pulmonary edema. The purpose of this study was to determine if exhaustive exercise would potentiate the toxic effects of TFD. One group of treadmill-acclimated rats was exercised to exhaustion following a 10-minute whole-body exposure to TFD. A second group was similarly exposed but not exercised. Two other groups of rats were sham exposed; one was exercised while one remained sedentary following the sham exposure. Twenty-four hours after exposure, the animals were sacrificed; the lungs were removed and weighed, and a portion was collected for histopathologic examination. The remaining lung tissue was allowed to dry to constant weight. There was no difference in endurance times between exposed and sham-exposed rats. There was a significant increase in the amount of pulmonary edema and associated pulmonary pathology in rats exercised following exposure to TFD. Eleven of twelve animals exercised following exposure to TFD and three of twelve animals which remained sedentary following exposure died by 24 hours. The degree of pulmonary pathology in all rats exposed to TFD was profound. RP MOORE, DH (reprint author), USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010, USA. NR 17 TC 1 Z9 1 U1 0 U2 1 PU MARCEL DEKKER INC PI NEW YORK PA 270 MADISON AVE, NEW YORK, NY 10016 SN 0148-0545 J9 DRUG CHEM TOXICOL JI Drug Chem. Toxicol. PY 1991 VL 14 IS 4 BP 343 EP 352 DI 10.3109/01480549109011638 PG 10 WC Chemistry, Multidisciplinary; Pharmacology & Pharmacy; Toxicology SC Chemistry; Pharmacology & Pharmacy; Toxicology GA GX320 UT WOS:A1991GX32000002 PM 1811957 ER PT J AU WOODARD, CL LUKEY, BJ AF WOODARD, CL LUKEY, BJ TI MMB-4 PHARMACOKINETICS IN RABBITS AFTER INTRAVENOUS AND INTRAMUSCULAR ADMINISTRATION SO DRUG METABOLISM AND DISPOSITION LA English DT Article RP WOODARD, CL (reprint author), USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010, USA. NR 4 TC 5 Z9 5 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0090-9556 J9 DRUG METAB DISPOS JI Drug Metab. Dispos. PD JAN-FEB PY 1991 VL 19 IS 1 BP 283 EP 284 PG 2 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA EU675 UT WOS:A1991EU67500050 PM 1673416 ER PT J AU HIGGINS, RC JENKINS, DL LEWIS, RP AF HIGGINS, RC JENKINS, DL LEWIS, RP TI TOTAL QUALITY MANAGEMENT IN THE CLASSROOM - LISTEN TO YOUR CUSTOMERS SO ENGINEERING EDUCATION LA English DT Article RP HIGGINS, RC (reprint author), USA,SCH ENGN & LOGIST,DEPT ENGN,TEXARKANA,TX, USA. NR 0 TC 1 Z9 1 U1 1 U2 1 PU AMER SOC ENG EDUC PI WASHINGTON PA 1818 N STREET,NW SUITE 600, WASHINGTON, DC 20036 SN 0022-0809 J9 ENG EDUC PD JAN-FEB PY 1991 VL 81 IS 1 BP 12 EP 14 PG 3 WC Education, Scientific Disciplines; Engineering, Multidisciplinary SC Education & Educational Research; Engineering GA EV663 UT WOS:A1991EV66300002 ER PT B AU MYLER, CA SISK, W AF MYLER, CA SISK, W BE SAYLER, GS FOX, R BLACKBURN, JW TI BIOREMEDIATION OF EXPLOSIVES CONTAMINATED SOILS (SCIENTIFIC QUESTIONS ENGINEERING REALITIES) SO ENVIRONMENTAL BIOTECHNOLOGY FOR WASTE TREATMENT SE ENVIRONMENTAL SCIENCE RESEARCH LA English DT Proceedings Paper CT SYMP ON ENVIRONMENTAL BIOTECHNOLOGY : MOVING FROM THE FLASK TO THE FIELD CY OCT 17-19, 1990 CL KNOXVILLE, TN SP INT TECHNOL, AMER CYANAMID, USAF, OFF SCI RES, UNIV TENNESSEE, WASTE MANAGEMENT RES & EDUC INST, OAK RIDGE WASTE MANAGEMENT ASSOC RP MYLER, CA (reprint author), USA,TOX & HAZARDOUS MAT AGCY,ABERDEEN PROVING GROUND,MD 21010, USA. NR 0 TC 32 Z9 32 U1 0 U2 0 PU PLENUM PRESS DIV PLENUM PUBLISHING CORP PI NEW YORK PA NEW YORK BN 0-306-43943-3 J9 ENVIR SCI R PY 1991 VL 41 BP 137 EP 146 PG 10 WC Environmental Sciences SC Environmental Sciences & Ecology GA BT23V UT WOS:A1991BT23V00013 ER PT J AU MAJOR, MA ROSENBLATT, DH BOSTIAN, KA AF MAJOR, MA ROSENBLATT, DH BOSTIAN, KA TI THE OCTANOL WATER PARTITION-COEFFICIENT OF METHYLMERCURIC CHLORIDE AND METHYLMERCURIC HYDROXIDE IN PURE WATER AND SALT-SOLUTIONS SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY LA English DT Note DE OCTANOL WATER PARTITION COEFFICIENT; METHYLMERCURY; KOW AB The 1-octanol/water partition coefficient (K(ow)) of methylmercury was determined at pH 7 in water and in aqueous solutions ranging from 0.0003 to 0.6000 M in sodium chloride. It was also determined over a pH range of 2 to 10 with a fixed sodium chloride concentration of 0.0045 M. In these experiments, K(ow) was seen to increase with increasing chloride concentrations in the range 0.0 to 0.075 M and to decrease with increasing pH above 7. Results were similar whether low levels of methylmercuric chloride or methylmercuric hydroxide were used as the starting materials. Partitioning was not affected by changes in ionic strength. C1 USA,MED RES INST INFECT DIS,FREDERICK,MD 21701. RP MAJOR, MA (reprint author), USA,BIOMED RES & DEV LAB,FREDERICK,MD 21701, USA. NR 11 TC 27 Z9 28 U1 8 U2 16 PU SETAC PRESS PI PENSACOLA PA 1010 NORTH 12TH AVE, PENSACOLA, FL 32501-3370 SN 0730-7268 J9 ENVIRON TOXICOL CHEM JI Environ. Toxicol. Chem. PY 1991 VL 10 IS 1 BP 5 EP 8 DI 10.1897/1552-8618(1991)10[5:TWPCOM]2.0.CO;2 PG 4 WC Environmental Sciences; Toxicology SC Environmental Sciences & Ecology; Toxicology GA EU280 UT WOS:A1991EU28000002 ER PT J AU TAYLOR, DN BLASER, MJ AF TAYLOR, DN BLASER, MJ TI THE EPIDEMIOLOGY OF HELICOBACTER-PYLORI INFECTION SO EPIDEMIOLOGIC REVIEWS LA English DT Review ID CAMPYLOBACTER-LIKE ORGANISMS; PEPTIC-ULCER DISEASE; PLACEBO-CONTROLLED TRIAL; UREA BREATH TEST; TO-PERSON TRANSMISSION; GASTRIC METAPLASIA; DUODENAL-ULCER; GASTRODUODENAL DISEASE; ANTIBODY PREVALENCE; NONULCER DYSPEPSIA C1 DEPT VET AFFAIRS MED CTR,NASHVILLE,TN. VANDERBILT UNIV,MED CTR,SCH MED,DEPT INFECT DIS,NASHVILLE,TN 37232. RP TAYLOR, DN (reprint author), WALTER REED ARMY MED CTR,DEPT ENTER INFECT,WASHINGTON,DC 20307, USA. NR 127 TC 456 Z9 466 U1 2 U2 13 PU JOHNS HOPKINS UNIV SCHOOL HYGIENE PUB HEALTH PI BALTIMORE PA 111 MARKET PLACE, STE 840, BALTIMORE, MD 21202-6709 SN 0193-936X J9 EPIDEMIOL REV JI Epidemiol. Rev. PY 1991 VL 13 BP 42 EP 59 PG 18 WC Public, Environmental & Occupational Health SC Public, Environmental & Occupational Health GA GY359 UT WOS:A1991GY35900003 PM 1765119 ER PT B AU SAWKA, MN LATZKA, WA PANDOLF, KB AF SAWKA, MN LATZKA, WA PANDOLF, KB BE Vanderwoude, LHV Meijs, PJM Vandergrinten, BA Deboer, YA TI UPPER-BODY EXERCISE - APPLICATION FOR WHEELCHAIR PROPULSION AND SPINAL-CORD INJURED POPULATIONS SO ERGONOMICS OF MANUAL WHEELCHAIR PROPULSION : STATE OF THE ART LA English DT Proceedings Paper CT WORKSHOP ON ERGONOMICS OF MANUAL WHEELCHAIR PROPULSION CY OCT 17-19, 1991 CL AMSTERDAM, NETHERLANDS SP COMMISS EUROPEAN COMMUNITIES, COMAC-BME, CONCERTED ACT MOBIL RESTORAT PARAL, YSED PERSONS, VRIJE UNIV AMSTERDAM, FAC HUMAN MOVEMENT SCI RP SAWKA, MN (reprint author), USA,ENVIRONM MED RES INST,NATICK,MA 01760, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU I O S PRESS PI AMSTERDAM PA AMSTERDAM BN 90-5199-118-5 PY 1991 BP 151 EP 162 PG 12 WC Ergonomics; Mechanics; Rehabilitation SC Engineering; Mechanics; Rehabilitation GA BY54H UT WOS:A1991BY54H00013 ER PT J AU WARTOFSKY, L GLINOER, D SOLOMON, B LAGASSE, R AF WARTOFSKY, L GLINOER, D SOLOMON, B LAGASSE, R TI DIFFERENCES AND SIMILARITIES IN THE TREATMENT OF DIFFUSE GOITER IN EUROPE AND THE UNITED-STATES SO EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY LA English DT Article; Proceedings Paper CT INTERNATIONAL THYROID SYMP ON THE 150TH ANNIVERSARY OF BASEDOWS DISEASE CY MAY 02-06, 1990 CL HALLE, GER DEM REP ID GRAVES-DISEASE; HYPERTHYROIDISM AB In two separate studies, members of the American Thyroid Association (ATA), and the European Thyroid Association (ETA) were surveyed by questionnaire on their management of Graves' disease. The aim was to determine how expert clinical thyroidologists employ three different therapies which are available for this disorder. Herein we summarize, compare and contrast similarities and differences in the results of these surveys. For the index patient, radioiodine (RAI) was the therapy of choice for 69% of ATA respondents but only 22% of ETA respondents. In contrast, only 30.5% of ATA respondents chose antithyroid drugs as first line therapy compared to 77% of ETA respondents. There was consensus on the relative lack of a role for thyroidectomy. The implication of these differing approaches to the treatment of hyperthyroidism due to Graves' disease are discussed. C1 UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. UNIV LIBRE BRUXELLES,HOP ST PIERRE,B-1000 BRUSSELS,BELGIUM. UNIV LIBRE BRUXELLES,FAC MED,ECOLE SANTE PUBL,B-1050 BRUSSELS,BELGIUM. RP WARTOFSKY, L (reprint author), WALTER REED ARMY MED CTR,ENDOCRINE METAB SERV,WASHINGTON,DC 20307, USA. NR 5 TC 17 Z9 18 U1 0 U2 0 PU JOHANN AMBROSIUS BARTH VERLAG PI HEIDELBERG PA IM WEIHER 10, D-69121 HEIDELBERG, GERMANY SN 0232-7384 J9 EXP CLIN ENDOCRINOL JI Exp. Clin. Endocrinol. PY 1991 VL 97 IS 2-3 BP 243 EP 251 PG 9 WC Endocrinology & Metabolism SC Endocrinology & Metabolism GA FP446 UT WOS:A1991FP44600023 PM 1717298 ER PT J AU MCCLEAN, MD AF MCCLEAN, MD TI LIP MUSCLE-REFLEX AND INTENTIONAL RESPONSE LEVELS IN A SIMPLE SPEECH TASK SO EXPERIMENTAL BRAIN RESEARCH LA English DT Article DE REFLEX; FACIAL; SENSORIMOTOR; SPEECH; LIPS; HUMAN ID SOMATOSENSORY EVOKED-POTENTIALS; PERIORAL REFLEX; STRETCH REFLEX; MOTOR CORTEX; MOVEMENT; MONKEY; CONTRACTION; MODULATION; NERVE; GAIN AB Sensorimotor integration in human lip muscle was studied by recording muscle activity while subjects produced simple speech utterances in response to mechanical stimulation. On each trial subjects were instructed either to produce the syllable "pa" or not respond when they detected movement of a small paddle held between the lips. Mechanical stimuli were adequate to elicit reflexes over poststimulus intervals of 15-30 ms (R1) and 30-50 ms (R2). EMG recordings were obtained from upper and lower lip muscles, and EMG levels were calculated for individual trials over several poststimulus time intervals. The independent effects of stimulus magnitude, prestimulus EMG, and reaction time on poststimulus response levels were assessed using multiple regression analysis. R1 and R2 levels were positively correlated with stimulus magnitude, but stimulus magnitude had little modulating effect on intentional lip muscle responses. Both reflex and intentional response levels showed positive associations with prestimulus EMG level. Instructional set had significant modulating effects on reflex responses in 9 of 10 subjects, but the nature of these effects varied among subjects. These various findings are discussed in relation to similar studies on limb motor systems and lip motor control for speech. RP MCCLEAN, MD (reprint author), WALTER REED ARMY MED CTR,CTR AUDIOL & SPEECH,WASHINGTON,DC 20307, USA. NR 39 TC 9 Z9 9 U1 0 U2 0 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0014-4819 J9 EXP BRAIN RES JI Exp. Brain Res. PY 1991 VL 87 IS 3 BP 662 EP 670 PG 9 WC Neurosciences SC Neurosciences & Neurology GA GT668 UT WOS:A1991GT66800020 PM 1783035 ER PT J AU ZOLTANI, CK BICEN, AF AF ZOLTANI, CK BICEN, AF TI VISUALIZATION OF FAN-SPREADING IN 2-PHASE JET FLOWS SO EXPERIMENTS IN FLUIDS LA English DT Note C1 IMPERIAL COLL SCI TECHNOL & MED,LONDON SW7 2BX,ENGLAND. RP ZOLTANI, CK (reprint author), USA,BALLIST RES LABS,ABERDEEN PROVING GROUND,MD 21005, USA. NR 3 TC 1 Z9 1 U1 0 U2 0 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0723-4864 J9 EXP FLUIDS JI Exp. Fluids PY 1991 VL 10 IS 5 BP 299 EP 300 PG 2 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA EY952 UT WOS:A1991EY95200010 ER PT J AU KAPPES, SF KIM, SS TANNER, PJ WILLIAMS, RJ COHN, LF AF KAPPES, SF KIM, SS TANNER, PJ WILLIAMS, RJ COHN, LF TI EMPLOYING EXPERT SYSTEM TECHNOLOGIES TO REAL-PROPERTY MANAGEMENT DECISION-MAKING (FINAL REPORT) SO EXPERT SYSTEMS WITH APPLICATIONS LA English DT Database Review RP KAPPES, SF (reprint author), CONSTRUCT ENGN RES LAB,CHAMPAIGN,IL, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0957-4174 J9 EXPERT SYST APPL JI Expert Syst. Appl. PY 1991 VL 3 IS 2 BP 298 EP 298 PG 1 WC Computer Science, Artificial Intelligence; Engineering, Electrical & Electronic; Operations Research & Management Science SC Computer Science; Engineering; Operations Research & Management Science GA GA436 UT WOS:A1991GA43600018 ER PT J AU KIM, HJ TAUB, IA AF KIM, HJ TAUB, IA TI SPECIFIC DEGRADATION OF MYOSIN IN MEAT BY BROMELAIN SO FOOD CHEMISTRY LA English DT Note AB The specificity of bromelain and papain for degradation of actin and myosin in meat was compared. Meat was treated with 0.1% enzyme for 0-60 min at 24-degrees-C and proteins, extracted with 6M urea containing 2% sodium dodecylsulfate (SDS) solution, were separated by SDS-polyacrylamide gel electrophoresis (PAGE). The profile of the extracted proteins clearly indicated that papain degrades myosin and actin at similar rates, whereas bromelain degrades myosin preferentially. This distinction could be useful in the development of freeze-dried meat products in which toughening of the meat due to the formation of high molecular weight aggregates from myosin cross-linking is minimized. RP KIM, HJ (reprint author), USA,NATICK RES & DEV LABS,CTR DEV & ENGN,FOOD ENGN DIRECTORATE,NATICK,MA 01760, USA. NR 15 TC 15 Z9 15 U1 1 U2 8 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB SN 0308-8146 J9 FOOD CHEM JI Food Chem. PY 1991 VL 40 IS 3 BP 337 EP 343 DI 10.1016/0308-8146(91)90117-7 PG 7 WC Chemistry, Applied; Food Science & Technology; Nutrition & Dietetics SC Chemistry; Food Science & Technology; Nutrition & Dietetics GA FF159 UT WOS:A1991FF15900009 ER PT J AU TANG, LC AF TANG, LC TI HUMAN ERYTHROCYTE AS A MODEL FOR INVESTIGATING MUSCARINIC AGONISTS AND ANTAGONISTS SO GENERAL PHARMACOLOGY LA English DT Article ID CENTRAL NERVOUS-SYSTEM; ACETYLCHOLINE-RECEPTOR; BINDING; RAT; IDENTIFICATION; BENZILATE; MEMBRANES; PROFILE; BRAIN AB 1. Human erythrocyte muscarinic receptor is further classified as M1 subtype by its binding of [H-3]pirenzepine (a specific M1 antagonist). Conversely, binding of [H3]piperidinyl AF-DX116 ( a specific M2 antagonist) is not detected. 2. There are high correlations between the binding efficacies of 25 known or putative cholinergic agents using either human erythrocyte membrane or mouse caudate homogenate. Also the in vitro data corresponds satisfactorily with in vivo data measuring the protective effect of these compounds against organophosphate poisoning. 3. The human erythrocyte membrane is an efficient model for investigating cholinergic agonists and antagonists. RP TANG, LC (reprint author), WALTER REED ARMY MED CTR,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307, USA. NR 23 TC 8 Z9 8 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0306-3623 J9 GEN PHARMACOL JI Gen. Pharmacol. PY 1991 VL 22 IS 3 BP 485 EP 490 DI 10.1016/0306-3623(91)90010-4 PG 6 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA FF884 UT WOS:A1991FF88400010 PM 1869021 ER PT J AU FRICKE, RF JORGE, J AF FRICKE, RF JORGE, J TI BENEFICIAL EFFECT OF DEXAMETHASONE IN DECREASING THE LETHALITY OF ACUTE T-2 TOXICOSIS SO GENERAL PHARMACOLOGY LA English DT Article ID TOXIN; RAT; METABOLITES AB 1. Steroidal and non-steroidal anti-inflammatory agents were evaluated for effectiveness for treatment of acute T-2 toxicosis in mice. 2. Non-steroidal agents, indomethacin, phenylbutazone, and acetylsalicylic acid, either were ineffective, or potentiated the lethality of T-2 toxin. 3. Of the anti-inflammatory steroids tested. dexamethasone was the most effective. 4. Dexamethasone was administered before, at the same time as, or after injection of T-2 toxin. 5. As the time between toxin exposure and treatment was increased, there was a corresponding increase in lethality. 6. In conclusion. steroidal. but not non-steroidal, anti-inflammatory agents were effective in decreasing T-2 toxin-induced lethality. C1 USA,MED RES INST INFECT DIS,FREDERICK,MD 21701. NR 25 TC 2 Z9 2 U1 1 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0306-3623 J9 GEN PHARMACOL JI Gen. Pharmacol. PY 1991 VL 22 IS 6 BP 1087 EP 1091 DI 10.1016/0306-3623(91)90582-Q PG 5 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA GT695 UT WOS:A1991GT69500016 PM 1810806 ER PT J AU CHAMBERS, FB MARCUS, MG THOMPSON, LS AF CHAMBERS, FB MARCUS, MG THOMPSON, LS TI MASS BALANCE OF WEST GULKANA GLACIER SO GEOGRAPHICAL REVIEW LA English DT Article ID SCALE ATMOSPHERIC CIRCULATION; WASHINGTON; USA AB Annual and longer-term mass-balance calculations provide a means to relate glacier behavior to climate. Selected representative glaciers are monitored for this purpose. West Gulkana Glacier, in the eastern Alaska Range, was among the glaciers mapped during the 1957-58 International Geophysical Year. It was remapped in 1986, after which twenty-nine-year mass balance was calculated. Annual budgets were also calculated for 1985-86 and 1986-87 glacier years. The three-decade record shows steady retreat and mass loss in the glacier's transitional marine-continental climate zone. West Gulkana Glacier is regionally representative of small, low-elevation valley systems. Caution must be exercised in relating its climatic responses to glaciers situated above 1,800 m. C1 US MIL ACAD,W POINT,NY 10996. ARIZONA STATE UNIV,GEOG,TEMPE,AZ 85287. RP CHAMBERS, FB (reprint author), UNIV CALIF DAVIS,GEOG,DAVIS,CA 95616, USA. NR 34 TC 4 Z9 4 U1 0 U2 1 PU GEOGRAPHICAL REVIEW PI NEW YORK PA SUITE 600 156 FIFTH AVENUE, NEW YORK, NY 10010 SN 0016-7428 J9 GEOGR REV JI Geogr. Rev. PD JAN PY 1991 VL 81 IS 1 BP 70 EP 86 DI 10.2307/215177 PG 17 WC Geography SC Geography GA FH124 UT WOS:A1991FH12400005 ER PT J AU JAROS, DL AF JAROS, DL TI CERCLA LANDFILL CLOSURES - CONSTRUCTION CONSIDERATIONS SO GEOTEXTILES AND GEOMEMBRANES LA English DT Article AB A properly functioning cover over an uncontrolled landfill which is regulated under the Comprehensive Environmental Response Compensation and Liability Act (CERCLA) depends on both a well-engineered cover design and prudent construction practices. This paper focuses on several geosynthetic construction issues which ultimately impact the performance of the final constructed cover. Preparation and placement issues related to subgrade preparation, geosynthetic placement, cover soil placement and test sections are presented. Storage and seaming of the geosynthetics are discussed. Construction quality control and quality assurance programs are emphasized. In addition, relevant design issues pertaining to settlements, interface friction, and rigid-nonrigid connections are discussed. Although these issues apply to all landfills, this paper is based on experience gained from design, review and construction oversight of CERCLA landfill covers by the US Army Corps of Engineers. RP JAROS, DL (reprint author), USA,CORPS ENGINEERS,MISSOURI RIVER DIV,POB 103,DOWNTOWN STN,OMAHA,NE 68101, USA. NR 0 TC 0 Z9 0 U1 0 U2 1 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB SN 0266-1144 J9 GEOTEXT GEOMEMBRANES JI Geotext. Geomembr. PY 1991 VL 10 IS 5-6 BP 393 EP 402 DI 10.1016/0266-1144(91)90032-R PG 10 WC Engineering, Geological; Geosciences, Multidisciplinary SC Engineering; Geology GA GQ340 UT WOS:A1991GQ34000003 ER PT J AU LETTERIE, GS HIBBERT, ML RAMIREZ, EJ AF LETTERIE, GS HIBBERT, ML RAMIREZ, EJ TI EXPECTANT MANAGEMENT OF ABNORMAL CONCENTRATIONS OF HUMAN CHORIONIC-GONADOTROPIN DURING THE 1ST-TRIMESTER OF PREGNANCY SO GYNECOLOGIC AND OBSTETRIC INVESTIGATION LA English DT Note DE HUMAN CHORIONIC GONADOTROPIN; EXPECTANT MANAGEMENT AB Abnormal serum human chorionic gonadotropin (hCG) levels during the first trimester may be associated with a nonviable intrauterine pregnancy or ectopic pregnancy. With the availability of sensitive hCG assays, expectant management of these patients may provide a viable alternative to surgery. To evaluate this approach, we managed 20 patients with low levels of serum hCG expectantly using serial hCG monitoring and clinical examination only. Serum hCG concentrations were followed to levels of < 10 mIU/ml. Peak levels of serum hCG ranged from 72 to 5,685 mIU/ml. Duration of expectant management ranged from 7 to 97 days. No patient required intervention due to acute symptoms. These data suggest that a select group of patients with decreasing hCG concentrations may be managed expectantly without undue morbidity thereby avoiding surgical intervention. RP LETTERIE, GS (reprint author), TRIPLER ARMY MED CTR,DEPT OBSTET & GYNECOL,REPROD ENDOCRINOL SERV,HONOLULU,HI 96859, USA. NR 5 TC 14 Z9 14 U1 0 U2 0 PU KARGER PI BASEL PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND SN 0378-7346 J9 GYNECOL OBSTET INVES JI Gynecol.Obstet.Invest. PY 1991 VL 31 IS 3 BP 176 EP 178 PG 3 WC Obstetrics & Gynecology SC Obstetrics & Gynecology GA FM663 UT WOS:A1991FM66300011 PM 2071058 ER PT B AU SJOGREN, MH COLICHON, A AF SJOGREN, MH COLICHON, A BE GERIN, JL PURCELL, RH RIZZETTO, M TI HEPATITIS-B AND DELTA-HEPATITIS INFECTION IN PERU SO HEPATITIS DELTA VIRUS SE PROGRESS IN CLINICAL AND BIOLOGICAL RESEARCH LA English DT Proceedings Paper CT 3RD INTERNATIONAL SYMP ON HEPATITIS DELTA VIRUS CY OCT 26-28, 1989 CL WASHINGTON, DC SP GEORGETOWN UNIV, MED CTR, NIAID, NIH, OSPEDALE MOLINETTE, ABBOTT LAB, IMMUNO, SCHERING PLOUGH, SK&F, SORIN BIOMEDICA, WELLCOME FDN RP SJOGREN, MH (reprint author), WALTER REED ARMY MED CTR,DEPT VIRUS DIS,WASHINGTON,DC 20307, USA. NR 0 TC 6 Z9 7 U1 0 U2 1 PU WILEY-LISS, INC PI NEW YORK PA NEW YORK BN 0-471-56073-1 J9 PROG CLIN BIOL RES JI Prog.Clin.Biol.Res. PY 1991 VL 364 BP 97 EP 104 PG 8 WC Medicine, Research & Experimental; Virology SC Research & Experimental Medicine; Virology GA BT15R UT WOS:A1991BT15R00011 PM 2020727 ER PT J AU BAUER, FA WEAR, DJ ANGRITT, P LO, SC AF BAUER, FA WEAR, DJ ANGRITT, P LO, SC TI MYCOPLASMA-FERMENTANS (INCOGNITUS STRAIN) INFECTION IN THE KIDNEYS OF PATIENTS WITH ACQUIRED-IMMUNODEFICIENCY-SYNDROME AND ASSOCIATED NEPHROPATHY - A LIGHT MICROSCOPIC, IMMUNOHISTOCHEMICAL, AND ULTRASTRUCTURAL-STUDY SO HUMAN PATHOLOGY LA English DT Article DE MYCOPLASMA; VIRUS-LIKE INFECTIOUS AGENT; ACQUIRED IMMUNODEFICIENCY SYNDROME; ACQUIRED IMMUNODEFICIENCY SYNDROME-ASSOCIATED NEPHROPATHY ID HIV-ASSOCIATED NEPHROPATHY; RENAL-DISEASE; AGENT VLIA; AIDS; VIRUS; IDENTIFICATION; MARKERS C1 ARMED FORCES INST PATHOL,DEPT INFECT & PARASIT DIS PATHOL,WASHINGTON,DC 20306. ARMED FORCES INST PATHOL,AMER REGISTRY PATHOL,WASHINGTON,DC 20306. WALTER REED ARMY MED CTR,DEPT PATHOL,WASHINGTON,DC 20307. NR 21 TC 76 Z9 76 U1 0 U2 0 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0046-8177 J9 HUM PATHOL JI Hum. Pathol. PD JAN PY 1991 VL 22 IS 1 BP 63 EP 69 DI 10.1016/0046-8177(91)90063-U PG 7 WC Pathology SC Pathology GA ET395 UT WOS:A1991ET39500011 PM 1985080 ER PT J AU MENA, H RIBAS, JL PEZESHKPOUR, GH COWAN, DN PARISI, JE AF MENA, H RIBAS, JL PEZESHKPOUR, GH COWAN, DN PARISI, JE TI HEMANGIOPERICYTOMA OF THE CENTRAL-NERVOUS-SYSTEM - A REVIEW OF 94 CASES SO HUMAN PATHOLOGY LA English DT Article DE HEMANGIOPERICYTOMA; HEMANGIOPERICYTIC MENINGIOMA; ANGIOBLASTIC MENINGIOMA; CENTRAL NERVOUS SYSTEM; NEOPLASM ID INTRACRANIAL HEMANGIOPERICYTOMA; ANGIOBLASTIC MENINGIOMA; MENINGEAL HEMANGIOPERICYTOMA; FEATURES; HEMANGIOBLASTOMAS; RESECTION; PATHOLOGY; CULTURE C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. RP MENA, H (reprint author), ARMED FORCES INST PATHOL,DEPT NEUROPATHOL,WASHINGTON,DC 20306, USA. NR 44 TC 164 Z9 181 U1 1 U2 4 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0046-8177 J9 HUM PATHOL JI Hum. Pathol. PD JAN PY 1991 VL 22 IS 1 BP 84 EP 91 DI 10.1016/0046-8177(91)90067-Y PG 8 WC Pathology SC Pathology GA ET395 UT WOS:A1991ET39500015 PM 1985083 ER PT J AU FARB, A BANKS, AK ROBINOWITZ, M FISTEL, S VIRMANI, R AF FARB, A BANKS, AK ROBINOWITZ, M FISTEL, S VIRMANI, R TI PERCUTANEOUS TRANSLUMINAL CORONARY ANGIOPLASTY GUIDEWIRE-INDUCED CORONARY-ARTERY DISSECTION WITHOUT BALLOON INFLATION SO HUMAN PATHOLOGY LA English DT Article DE CORONARY ARTERY; DISSECTION; ANGIOPLASTY; PATHOLOGY ID STENOSIS C1 ARMED FORCES INST PATHOL,DEPT CARDIOVASC PATHOL,WASHINGTON,DC 20306. WALTER REED ARMY MED CTR,DIV CARDIOL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT PATHOL,WASHINGTON,DC 20307. NR 9 TC 1 Z9 1 U1 0 U2 1 PU W B SAUNDERS CO PI PHILADELPHIA PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA 19106-3399 SN 0046-8177 J9 HUM PATHOL JI Hum. Pathol. PD JAN PY 1991 VL 22 IS 1 BP 97 EP 98 DI 10.1016/0046-8177(91)90070-6 PG 2 WC Pathology SC Pathology GA ET395 UT WOS:A1991ET39500018 PM 1985086 ER PT J AU ANDRISANI, D FUNG, TK SCHIERMAN, J KUHL, FP AF ANDRISANI, D FUNG, TK SCHIERMAN, J KUHL, FP TI A NONLINEAR HELICOPTER TRACKER USING ATTITUDE MEASUREMENTS SO IEEE TRANSACTIONS ON AEROSPACE AND ELECTRONIC SYSTEMS LA English DT Article AB Discussed here are extended Kalman filter based trackers for maneuvering helicopters that use body angle and rotor tip path plane angle measurements in addition to the usual radar position measurements. Improvements were found in tracker performance when the body rotation and rotor tip path plane degrees of freedom were modeled within the extended Kalman filter. Tracker performance was further improved when measurements of body angles and rotor tip-path-plane angles were made available to the tracker. C1 USA,ARNAMENT ENGN CTR & RES DEV,PICATINNY ARSENAL,NJ 07806. RP ANDRISANI, D (reprint author), PURDUE UNIV,SCH AERONAUT & ASTRONAUT,W LAFAYETTE,IN 47907, USA. NR 9 TC 14 Z9 14 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9251 J9 IEEE T AERO ELEC SYS JI IEEE Trans. Aerosp. Electron. Syst. PD JAN PY 1991 VL 27 IS 1 BP 40 EP 47 DI 10.1109/7.68146 PG 8 WC Engineering, Aerospace; Engineering, Electrical & Electronic; Telecommunications SC Engineering; Telecommunications GA EY693 UT WOS:A1991EY69300005 ER PT J AU BENO, JH WELDON, WF AF BENO, JH WELDON, WF TI ACTIVE CURRENT MANAGEMENT FOR FOUR-RAIL RAILGUNS SO IEEE TRANSACTIONS ON MAGNETICS LA English DT Article; Proceedings Paper CT 5TH SYMP ON ELECTROMAGNETIC LAUNCHER TECHNOLOGY CY APR 03-05, 1990 CL SANDESTIN, FL AB A system of auxiliary conductors designed to reduce current density peaks in railgun rails for four-rail, round-bore railguns is described. The effects on rail current density and projectile force are discussed. Railgun cross-sectional designs are presented for round-bore, four-rail railguns which operate at lower peak current densities and develop greater projectile forces than conventional two-rail, round-bore railguns. C1 UNIV TEXAS,CTR ELECTROMECH,AUSTIN,TX 78758. RP BENO, JH (reprint author), USA,WASHINGTON,DC 20310, USA. NR 2 TC 3 Z9 3 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9464 J9 IEEE T MAGN JI IEEE Trans. Magn. PD JAN PY 1991 VL 27 IS 1 BP 39 EP 44 DI 10.1109/20.100990 PG 6 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA ER831 UT WOS:A1991ER83100007 ER PT J AU BENO, JH AF BENO, JH TI 3-DIMENSIONAL RAIL-CURRENT DISTRIBUTION NEAR THE ARMATURE OF SIMPLE, SQUARE-BORE, 2-RAIL RAILGUNS SO IEEE TRANSACTIONS ON MAGNETICS LA English DT Article; Proceedings Paper CT 5TH SYMP ON ELECTROMAGNETIC LAUNCHER TECHNOLOGY CY APR 03-05, 1990 CL SANDESTIN, FL AB Vector potential is solved as a three dimensional, boundary value problem for a conductor geometry consisting of square-bore railgun rails and a stationary armature. Conductors are infinitely conducting and perfect contact is assumed between rails and the armature. From the vector potential solution, surface current distribution is inferred. RP BENO, JH (reprint author), USA,WASHINGTON,DC 20310, USA. NR 12 TC 1 Z9 1 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9464 J9 IEEE T MAGN JI IEEE Trans. Magn. PD JAN PY 1991 VL 27 IS 1 BP 106 EP 111 DI 10.1109/20.101003 PG 6 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA ER831 UT WOS:A1991ER83100020 ER PT J AU MCNAB, IR FLETCHER, JS SUCOV, EW RUSTAN, PL HUEBSCHMAN, ML AF MCNAB, IR FLETCHER, JS SUCOV, EW RUSTAN, PL HUEBSCHMAN, ML TI THUNDERBOLT SO IEEE TRANSACTIONS ON MAGNETICS LA English DT Article; Proceedings Paper CT 5TH SYMP ON ELECTROMAGNETIC LAUNCHER TECHNOLOGY CY APR 03-05, 1990 CL SANDESTIN, FL AB The Thunderbolt program is being conducted by the Westinghouse Marine Division in Sunnyvale, CA, with funding from the Strategic Defense Initiative Organization's Innovation Science and Technology Office, and managed by the RAEV Division of the Defense Nuclear Agency. The facility will provide 60 MJ of energy at 21 kV from capacitor banks for powering breech-fed or distributed energy railgun electromagnetic launchers. After discharge from the capacitor banks, the energy pulse is shaped with room temperature solenoidal inductors, with switching being provided by D- and E-sized ignitrons. Fast recharging of the capacitor banks could permit repetitive operation. A screened room provides protection for the control and data acquisition equipment, while a single-point grounding scheme protects against ground loops. A substantial foundation provides support for the catch tank, while high-vacuum equipment will permit operation at high velocities with the round bore railgun. Preinjection of the test projectiles to velocities of about 1 km/s is provided by a helium gas gun to minimize damage to the breech section of the railgun. In addition to providing more details on Thunderbolt, this paper describes operating experience and results obtained with a subscale launcher (SUVAC II) at the Westinghouse R&D Center in Pittsburgh, PA. Data obtained at this facility has led to the selection of materials and operating techniques for Thunderbolt. C1 WESTINGHOUSE RES & DEV CTR,PITTSBURGH,PA. USAF,SDIO,IST,WASHINGTON,DC 20330. USA,SDIO,IST,WASHINGTON,DC 20310. RP MCNAB, IR (reprint author), WESTINGHOUSE ELECT CORP,SUNNYVALE,CA, USA. NR 6 TC 17 Z9 17 U1 1 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9464 J9 IEEE T MAGN JI IEEE Trans. Magn. PD JAN PY 1991 VL 27 IS 1 BP 130 EP 135 DI 10.1109/20.101008 PG 6 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA ER831 UT WOS:A1991ER83100025 ER PT J AU GRZESIK, RG MITCHELL, DE SEBASTIAN, JH CHIN, IW KOSTAKIS, SA AF GRZESIK, RG MITCHELL, DE SEBASTIAN, JH CHIN, IW KOSTAKIS, SA TI E/M LAUNCHER VIBRATION AND ACCELERATION DATA-ANALYSIS SO IEEE TRANSACTIONS ON MAGNETICS LA English DT Article; Proceedings Paper CT 5TH SYMP ON ELECTROMAGNETIC LAUNCHER TECHNOLOGY CY APR 03-05, 1990 CL SANDESTIN, FL AB Acquired acceleration curves for projectiles electromagnetically launched out of the non-stiff, (epoxy fiber wrapped copper rails) 50mm Benet barrel were very noisy and difficult to interpret. The cause for the noise was assumed to be the induced vibration from the barrel and projectile. Standard numerical smoothing techniques were not deemed plausible candidates for mathematical analysis because using them alone would have resulted in curves which would have been superficially smoothed over, concealing possibly interesting transient responses and/or distorting valuable acceleration data. The barrel low frequency vibrations were too interwoven with the acceleration signal and could not be extracted non-intrusively, and the high frequency barrel vibrations were not apparent. The projectile vibrations turned out to be negligible being on the order of magnitude of the accelerometer's background noise. A low pass filter was sufficiently used to extract the influence of the noise from the acquired data resulting in curves that were smoothed with a clear perspective and understanding of the physical system underlying the cause of the noise. The part of the oscillatory acceleration signal that remained was accounted for by the forces from the injector and the current pulse in the rails. This was quantitatively verified with break fiber data using Newtonian mechanics and qualitatively compared to injector-only tests which used the relatively stiff ceramic Agate barrel. The Benet barrel was also tested under impulse and oscillatory conditions. In the first experiment, a hammer pulse induced a vibration in the barrel and a PCB Piezotronics accelerometer of appropriate range detected the induced vibration. Variation of impulse location on the barrel clearly showed time dependance of the resonant frequencies. In the second experiment, a membrane vibrated the barrel and projectile at specified frequencies. The induced resonant frequency depends on the physical dimensions of the barrel and projectile and depends on the velocity of the propagating wave through the component materials. The analytical approach involved the use of standard Fourier transforms linked with the analysis of barrel and projectile vibrational mode possibilities. The experimental setups are described in detail and the data is plotted with a comparison to theoretical expectations. C1 USA,ARDEC,PICATINNY ARSENAL,NJ 07806. RP GRZESIK, RG (reprint author), PARKER KINET DESIGNS INC,BLDG 329,PICATINNY ARSENAL,NJ 07806, USA. NR 3 TC 0 Z9 0 U1 1 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9464 J9 IEEE T MAGN JI IEEE Trans. Magn. PD JAN PY 1991 VL 27 IS 1 BP 147 EP 151 DI 10.1109/20.101012 PG 5 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA ER831 UT WOS:A1991ER83100029 ER PT J AU BANNISTER, KA BURTON, L DRYSDALE, WH AF BANNISTER, KA BURTON, L DRYSDALE, WH TI STRUCTURAL DESIGN ISSUES FOR ELECTROMAGNETIC PROJECTILES SO IEEE TRANSACTIONS ON MAGNETICS LA English DT Article; Proceedings Paper CT 5TH SYMP ON ELECTROMAGNETIC LAUNCHER TECHNOLOGY CY APR 03-05, 1990 CL SANDESTIN, FL AB Many structural design issues associated with electromagnetic launch of projectiles will respond to the same techniques as are used for conventional gun launch. The methods used to assess and manage the loads associated with the axial propulsive force (tapered sabots), with rapid propulsive rise time (dynamic finite element analysis), and with transverse balloting loads (coupled projectile/gun models) are interpreted for high velocity, electromagnetically accelerated projectiles. Finally some conclusions from these conventional interior ballistic technologies are offered for the EM designer. RP BANNISTER, KA (reprint author), USA,BALLIST RES LAB,ABERDEEN PROVING GROUND,MD 21005, USA. NR 6 TC 1 Z9 1 U1 0 U2 0 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9464 J9 IEEE T MAGN JI IEEE Trans. Magn. PD JAN PY 1991 VL 27 IS 1 BP 464 EP 469 DI 10.1109/20.101077 PG 6 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA ER831 UT WOS:A1991ER83100094 ER PT J AU ZIELINSKI, AE GARNER, JM AF ZIELINSKI, AE GARNER, JM TI MASS STABILIZED PROJECTILE DESIGNS FOR ELECTROMAGNETIC LAUNCH SO IEEE TRANSACTIONS ON MAGNETICS LA English DT Article; Proceedings Paper CT 5TH SYMP ON ELECTROMAGNETIC LAUNCHER TECHNOLOGY CY APR 03-05, 1990 CL SANDESTIN, FL AB A dual density Rodman cone, with 1/d = 7, has been found to be attractive for electromagnetic launch and may have adequate terminal ballistic performance. Stable flight is achieved from the correct distribution of mass within the projectile body. The design provides some flexibility for the armature in that all the armature mass is used for aerodynamic stability. Furthermore, the acceleration can be supported by a simple one-piece armature. A bore rider, which is less than 10% of the total mass, is needed for in-bore stability and structural support at the tungsten/aluminum interface. Work to date has focused on small caliber applications, but substantial gains can be achieved when the bore size is increased to cannon caliber. General design principles are presented for a mass stabilized projectile. This paper addresses nearly all aspects of launch, flight, and terminal effects as a function of bore size. Flight and terminal effects are computed from curve fits to existing experimental data. RP ZIELINSKI, AE (reprint author), USA,BALLIST RES LABS,LABCOM,ABERDEEN PROVING GROUND,MD 21005, USA. NR 8 TC 1 Z9 1 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9464 J9 IEEE T MAGN JI IEEE Trans. Magn. PD JAN PY 1991 VL 27 IS 1 BP 515 EP 520 DI 10.1109/20.101086 PG 6 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA ER831 UT WOS:A1991ER83100103 ER PT J AU ZIELINSKI, AE AF ZIELINSKI, AE TI DESIGN LIMITATIONS FOR SMALL CALIBER ELECTROMAGNETIC SABOTED ROD PROJECTILES SO IEEE TRANSACTIONS ON MAGNETICS LA English DT Article; Proceedings Paper CT 5TH SYMP ON ELECTROMAGNETIC LAUNCHER TECHNOLOGY CY APR 03-05, 1990 CL SANDESTIN, FL AB In any application of electromagnetic launch, the armature package must conform to the barrel and provide the desired terminal performance. Finned long rod projectiles have proven to be viable candidates for both flight bodies and terminal effectiveness. This paper describes the criteria necessary for integrating a solid armature with a conventional type finned rod. An initial design is presented for a rod projectile, launched from a 15.24 mm (.60 caliber) augmented railgun with a sinusoidal driving current. Other designs are assessed in order to explore improvements and scalability to other bore diameters. We evaluate the final armature design considering: launch, flight, and terminal effects. Ohmic heating, structural limitations, and barrel parameters are also discussed. Flight and aerodynamic data are scaled from existing finned rod projectile data bases to calculate horizontal flat-trajectory performance. Finally, terminal effects are incorporated for a simple rolled homogeneous armor (RHA) target. RP ZIELINSKI, AE (reprint author), USA,BALLIST RES LABS,LABCOM,ABERDEEN PROVING GROUND,MD 21005, USA. NR 9 TC 3 Z9 3 U1 1 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0018-9464 J9 IEEE T MAGN JI IEEE Trans. Magn. PD JAN PY 1991 VL 27 IS 1 BP 521 EP 526 DI 10.1109/20.101087 PG 6 WC Engineering, Electrical & Electronic; Physics, Applied SC Engineering; Physics GA ER831 UT WOS:A1991ER83100104 ER PT J AU BALLATO, A KOSINSKI, J LUKASZEK, T AF BALLATO, A KOSINSKI, J LUKASZEK, T TI LITHIUM TETRABORATE TRANSDUCERS SO IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL LA English DT Article ID PIEZOELECTRIC PLATES; FIELD EXCITATION; ADMITTANCE AB Lithium tetraborate is a tetragonal material of considerable promise for frequency control and signal processing applications. It exhibits piezoelectric coupling values that fall between those of lithium niobate and quartz, but possesses orientations for which the temperature coefficient of frequency and delay time is zero for bulk and surface acoustic waves. The properties of two doubly rotated bulk wave resonator orientations having both first- and second-order temperature coefficients equal to zero are discussed. These are suitable for shear and compressional wave transducers in applications where very low temperature sensitivity is required simultaneously with moderately strong piezocoupling coefficients. C1 USA,RES & DEV LABS,FT MONMOUTH,NJ 07703. RP BALLATO, A (reprint author), USA,ELECTR TECHNOL & DEVICES LAB,FT MONMOUTH,NJ 07703, USA. NR 32 TC 7 Z9 7 U1 0 U2 1 PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2394 SN 0885-3010 J9 IEEE T ULTRASON FERR JI IEEE Trans. Ultrason. Ferroelectr. Freq. Control PD JAN PY 1991 VL 38 IS 1 BP 62 EP 66 DI 10.1109/58.67836 PG 5 WC Acoustics; Engineering, Electrical & Electronic SC Acoustics; Engineering GA EP653 UT WOS:A1991EP65300008 PM 18267558 ER PT J AU PICCOLI, M SANTONI, G SANTONI, A FRATI, L HERBERMAN, RB CHIRIGOS, MA AF PICCOLI, M SANTONI, G SANTONI, A FRATI, L HERBERMAN, RB CHIRIGOS, MA TI INHIBITION OF NK-CELL GENERATION BY CORYNEBACTERIUM PARVUM SO IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY LA English DT Article ID NATURAL-KILLER CELLS; LARGE GRANULAR LYMPHOCYTES; BONE-MARROW; EFFECTOR-CELLS; SUPPRESSOR CELLS; MOUSE NK; MICE; SPLEEN; MACROPHAGES; LYMPHOKINE AB Treatment of mice with Corynebacterium parvum (Cp) resulted in a substantial decrease of splenic NK activity associated with a reduced number of LGL. Cp also inhibited in vitro augmentation of NK cytotoxicity by IFN or IL-2 as well as generation of LAK activity. Localization experiments by using radiolabelled LGL indicated that the lower number of LGL in the spleen was not attributable to a Cp-induced alteration of LGL homing. Finally Cp was found to affect the ability of bone marrow cells to reconstitute NK activity in lethally irradiated mice, indicating that it can interfere with development of NK cells from bone marrow progenitors. C1 UNIV MACERATA,INST FORENS SCI,MACERATA,SPAIN. UNIV ROME LA SAPIENZA,DEPT EXPTL MED,I-00185 ROME,ITALY. PITTSBURGH CANC INST,PITTSBURGH,PA. USA,MED RES INST INFECT DIS,FREDERICK,MD 21701. OI Santoni, Giorgio/0000-0003-2757-7064 NR 40 TC 2 Z9 2 U1 0 U2 0 PU MARCEL DEKKER INC PI NEW YORK PA 270 MADISON AVE, NEW YORK, NY 10016 SN 0892-3973 J9 IMMUNOPHARM IMMUNOT JI Immunopharmacol. Immunotoxicol. PY 1991 VL 13 IS 4 BP 513 EP 529 DI 10.3109/08923979109019720 PG 17 WC Immunology; Pharmacology & Pharmacy; Toxicology SC Immunology; Pharmacology & Pharmacy; Toxicology GA GW222 UT WOS:A1991GW22200004 PM 1723083 ER PT J AU PARK, OC AF PARK, OC TI RESEARCH ON INSTRUCTION - DESIGN AND EFFECTS - DIJKSTRA,S, VANHOUTWOLTERS,BHAM, VANDERSIJDE,PC SO INSTRUCTIONAL SCIENCE LA English DT Book Review RP PARK, OC (reprint author), USA,BEHAV & SOCIAL SCI RES INST,5001 EISENHOWER AVE,ALEXANDRIA,VA 22333, USA. NR 4 TC 0 Z9 0 U1 0 U2 0 PU KLUWER ACADEMIC PUBL PI DORDRECHT PA SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS SN 0020-4277 J9 INSTR SCI JI Instr. Sci. PY 1991 VL 20 IS 4 BP 345 EP 347 PG 3 WC Education & Educational Research; Psychology, Educational SC Education & Educational Research; Psychology GA GQ673 UT WOS:A1991GQ67300006 ER PT J AU OLSON, AK GOERIG, AC CAVATAIO, RE LUCIANO, J AF OLSON, AK GOERIG, AC CAVATAIO, RE LUCIANO, J TI THE ABILITY OF THE RADIOGRAPH TO DETERMINE THE LOCATION OF THE APICAL FORAMEN SO INTERNATIONAL ENDODONTIC JOURNAL LA English DT Article AB An in-vitro radiographic study of human teeth was performed in order to evaluate the ability of radiographs to determine the location of the apical foramen. The tip of an endodontic file was positioned at the apical foramen of each canal in 117 extracted human teeth (213 canals) and in 56 teeth (92 canals) still within the alveolus of dried jaw specimens. Parallel radiographs were taken in a bucco-lingual plane of all teeth. The tip of the instrument appeared to be at the root surface (apical foramen) in 82 per cent of canals. There was no significant difference in results between the teeth radiographed in the alveolus of dried jaw specimens and extracted teeth when the radiographs were evaluated under a stereomicroscope. C1 USA,DENT ACTIV,FT CAMPBELL,KY. NR 0 TC 33 Z9 37 U1 0 U2 0 PU BLACKWELL SCIENCE LTD PI OXFORD PA OSNEY MEAD, OXFORD, OXON, ENGLAND OX2 0EL SN 0143-2885 J9 INT ENDOD J JI Int. Endod. J. PD JAN PY 1991 VL 24 IS 1 BP 28 EP 35 DI 10.1111/j.1365-2591.1991.tb00867.x PG 8 WC Dentistry, Oral Surgery & Medicine SC Dentistry, Oral Surgery & Medicine GA EU697 UT WOS:A1991EU69700005 PM 1917086 ER PT J AU MORENOSANCHEZ, R BRAVO, C GUTIERREZ, J NEWMAN, AH CHIANG, PK AF MORENOSANCHEZ, R BRAVO, C GUTIERREZ, J NEWMAN, AH CHIANG, PK TI RELEASE OF CA-2+ FROM HEART AND KIDNEY MITOCHONDRIA BY PERIPHERAL-TYPE BENZODIAZEPINE RECEPTOR LIGANDS SO INTERNATIONAL JOURNAL OF BIOCHEMISTRY LA English DT Article ID BINDING-SITES; RAT-BRAIN; AUTORADIOGRAPHIC LOCALIZATION; OXIDATIVE-PHOSPHORYLATION; SUBCELLULAR-DISTRIBUTION; MEMBRANE-PERMEABILITY; CALCIUM CHANNELS; INNER MEMBRANE; INHIBITION; DIMINUTION AB 1. The effect of the benzodiazepines Ro5-4864, AHN 086 and clonazepam on the release of Ca2+ from rat heart and kidney mitochondria was studied. 2. The peripheral-type benzodiazepines Ro5-4864 and AHN 086 induced Ca2+ release which was blocked by Mg2+ whereas the central-type benzodiazepine clonazepam was ineffective. 3. An associated collapse of membrane potential and swelling were also induced by AHN 086 in the presence of Ca2+. 4. However, no oxidation of pyridine nucleotides or increased rate or respiration were observed. 5. Release of Sr2+ was induced by AHN 086 in the absence of inorganic phosphate but not in its presence. 6. These data are discussed in the context of the current hypotheses on the mechanism of mitochondrial Ca2+ release. C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. RP MORENOSANCHEZ, R (reprint author), INST NACL CARDIOL,DEPT BIOQUIM,MEXICO CITY 014080,DF,MEXICO. OI Moreno-Sanchez, Rafael/0000-0002-9587-7184 NR 43 TC 22 Z9 22 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0020-711X J9 INT J BIOCHEM JI Int. J. Biochem. PY 1991 VL 23 IS 2 BP 207 EP 213 DI 10.1016/0020-711X(91)90191-O PG 7 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA EN936 UT WOS:A1991EN93600011 PM 1847885 ER PT J AU FARZANEH, NK WALDEN, TL HEARING, VJ GERSTEN, DM AF FARZANEH, NK WALDEN, TL HEARING, VJ GERSTEN, DM TI COMPARISON OF THE METABOLIC-FATE AND TISSUE DISTRIBUTION OF B700, AN ALBUMIN-LIKE MELANOMA-SPECIFIC ANTIGEN WITH SERUM-ALBUMIN IN NORMAL AND TUMOR-BEARING MICE SO INTERNATIONAL JOURNAL OF BIOCHEMISTRY LA English DT Article ID MURINE B-16 MELANOMA; MALIGNANT-MELANOMA; BINDING-PROTEIN; GROWTH; INVIVO AB 1. B700, a murine melanoma antigen, is a member of the serum albumin protein family, being closely related to murine serum albumin (MSA). 2. We have studied and compared the metabolic fate and anatomic distribution of radioiodinated B700 and MSA administered to semisyngeneic naive and tumor-bearing mice. 3. Labelled material from both proteins is excreted primarily into urine. 4. The rate of excretion of the two proteins is markedly different, with B700 having a shorter half-life in the body. 5. Despite their similar molecular weights, intact B700 represents approx. 30% of the radioactivity in the urine but only 4% of the MSA in the urine is intact. 6. These studies demonstrate that the host can readily distinguish between very similar normal (MSA) and tumor-associated (B700) molecules and process them differently. 7. Similar findings of differential fate and distribution have been reported in comparing other albuminoid molecules [Dueland S., Blomhoff R. and Pedersen J. I. (1990) Biochem. J. 267, 721-725]. C1 GEORGETOWN UNIV,SCH MED,DEPT PATHOL,WASHINGTON,DC 20007. USA,RADIOBIOL RES INST,DEPT RADIAT BIOCHEM,BETHESDA,MD 20814. NCI,CELL BIOL LAB,BETHESDA,MD 20892. NR 25 TC 2 Z9 2 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0020-711X J9 INT J BIOCHEM JI Int. J. Biochem. PY 1991 VL 23 IS 12 BP 1385 EP 1391 DI 10.1016/0020-711X(91)90279-V PG 7 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA GP203 UT WOS:A1991GP20300006 PM 1761148 ER PT J AU CHIRIGOS, MA USSERY, MA BLACK, PL AF CHIRIGOS, MA USSERY, MA BLACK, PL TI IMEXON AND BIOLOGICAL RESPONSE MODIFIERS IN MURINE MODELS OF AIDS SO INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY LA English DT Article ID IMMUNE-DEFICIENCY SYNDROME; NATURAL-KILLER CELLS; INTERFERON-ALPHA; LEUKEMIA-VIRUS; MICE AB The Rauscher murine leukemia retrovirus system provides an in vivo model of the human acquired immune deficiency syndrome for testing the ability of antiviral agents and biological response modifiers (BRM) to suppress viremia and retroviral disease. In the present report we examined three agents in the Rauscher retrovirus model: imexon, Ampligen and poly[I,C]-LC. Imexon reduced splenomegaly, viremia, and serum reverse transcriptase levels even when treatment was not initiated until 7 days after virus infection. Imexon also significantly prolonged the survival of infected mice. Thus it proved to be an effective antiviral agent in this system, although imexon did not completely eliminate retroviral infection in treated mice. Poly[I,C]-LC and Ampligen had immunomodulatory effects. Both of these BRM augmented the cytolytic activity of splenic natural killer (NK) cells in infected animals when treatment was initiated 24 h after infection. Poly[I,C]-LC had antiretroviral activity when administered on this schedule. In order to examine the role of NK cell augmentation in the antiviral activity of poly[I,C]-LC, we attempted to deplete NK activity by treatment with rabbit antibody to asialo GM1, a ganglioside on the surface of murine NK cells. Combined treatment of infected mice with poly[I,C]-LC and anti-asialo GM, decreased the antiviral activity of poly[I,C]-LC. This finding suggests that NK cells may be involved in the antiviral effect of this BRM. C1 US FDA,DIV ANTIVIRAL DRUG PROD,HFD-530,ROCKVILLE,MD 20857. USA,INFECT DIS RES INST,FREDERICK,MD 21702. SO RES INST,FREDERICK RES CTR,FREDERICK,MD 21701. FU PHS HHS [1U01A125617] NR 23 TC 3 Z9 3 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0192-0561 J9 INT J IMMUNOPHARMACO JI Int. J. Immunopharmacol. PY 1991 VL 13 SU 1 BP 33 EP 41 DI 10.1016/0192-0561(91)90122-N PG 9 WC Immunology; Pharmacology & Pharmacy SC Immunology; Pharmacology & Pharmacy GA HP981 UT WOS:A1991HP98100005 PM 1823906 ER PT J AU BIRX, DL REDFIELD, RR AF BIRX, DL REDFIELD, RR TI HIV VACCINE THERAPY SO INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY LA English DT Article ID SEROPOSITIVE INDIVIDUALS; LYMPHOCYTES-T; ANTIBODIES; COMPLEX; CELLS; AIDS AB The immunoregulatory mechanisms responsible for effective the in vivo post-infection control of HIV are unknown. In the setting of natural HIV infection, host-directed immune responses directed against gp120 are minimal. This includes poor gp120 epitope specific antibody responses to C1, C2 and C3; lack of T-cell recognition and proliferation to gp120; and minimal envelope cytotoxic T-cell responses. The historical important of anti-envelope responses in the control of other viral pathogens, coupled with the paucity of anti-envelope responses elicited as a consequence of HIV infection, formed the basis for our rationale to pursued a research program which focused on post-infection vaccination utilizing HIV enveloped derived products. Recently we have demonstrated the scientific feasibility of post-infection vaccination with an HIV envelope based vaccine to broaden host-directed HIV-specific immune responses to include seroconversion to gp120 C1, C2 and C3; the induction of T-cell recognition to gp160; and cytotoxic T-cell responses to envelope peptides. The in vivo safety and immunogenicity of the product in adult patients with early HIV infection has been demonstrated. An expanded phase II trial with rgp160 (MGS) is ongoing to examine the potential role of HIV-specific vaccine therapy to alter the natural history of HIV infection. Finally, we are exploring the value of post-infection immunization in defining specific immune responses and their in vivo HIV immunoregulatory relevance. C1 WALTER REED ARMY MED CTR,DEPT RETROVIRAL RES,ROCKVILLE,MD 20850. NR 11 TC 5 Z9 5 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0192-0561 J9 INT J IMMUNOPHARMACO JI Int. J. Immunopharmacol. PY 1991 VL 13 SU 1 BP 129 EP 132 DI 10.1016/0192-0561(91)90134-S PG 4 WC Immunology; Pharmacology & Pharmacy SC Immunology; Pharmacology & Pharmacy GA HP981 UT WOS:A1991HP98100017 PM 1823904 ER PT J AU SORENSEN, BR KIMSEY, KD SILSBY, GF SCHEFFLER, DR SHERRICK, TM DEROSSET, WS AF SORENSEN, BR KIMSEY, KD SILSBY, GF SCHEFFLER, DR SHERRICK, TM DEROSSET, WS TI HIGH-VELOCITY PENETRATION OF STEEL TARGETS SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING LA English DT Article AB Researchers at the U.S. Army Ballistic Research Laboratory (BRL) have conducted a combined experimental and numerical research program in high-velocity penetration aimed at increasing the understanding of penetration mechanics over the striking velocity range between 1.5 and 4 km/s. A judicious combination of ballistic tests and large-scale simulations have been used to evaluate the performance of a family of both monolithic and segmented penetrators against semi-infinite rolled homogeneous armor (RHA). The results of the experimental and numerical programs are discussed. RP SORENSEN, BR (reprint author), USA,BALLIST RES LABS,ABERDEEN PROVING GROUND,MD 21005, USA. NR 0 TC 42 Z9 46 U1 0 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0734-743X J9 INT J IMPACT ENG JI Int. J. Impact Eng. PY 1991 VL 11 IS 1 BP 107 EP 119 DI 10.1016/0734-743X(91)90034-D PG 13 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA FF932 UT WOS:A1991FF93200007 ER PT J AU WALTERS, WP SEGLETES, SB AF WALTERS, WP SEGLETES, SB TI AN EXACT SOLUTION OF THE LONG ROD PENETRATION EQUATIONS SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING LA English DT Article AB An exact solution is presented for the long rod penetration equations first formulated by Alekseevski in 1966 and independently by Tate in 1967. This analytical solution allows a faster and easier solution of the penetration equations, since stability considerations associated with any numerically integrated solutions are avoided. Additionally, an analytical solution provides greater insight into the penetration mechanism than a comparable numerically integrated solution. RP WALTERS, WP (reprint author), USA,BALLIST RES LABS,ABERDEEN PROVING GROUND,MD 21005, USA. NR 0 TC 8 Z9 9 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0734-743X J9 INT J IMPACT ENG JI Int. J. Impact Eng. PY 1991 VL 11 IS 2 BP 225 EP 231 DI 10.1016/0734-743X(91)90008-4 PG 7 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA FX753 UT WOS:A1991FX75300008 ER PT J AU KIDD, JA AF KIDD, JA TI THE EFFECT OF FLEXURAL STRAIN ON THE TRANSMISSIVITY OF OPTICAL FIBER SO INTERNATIONAL JOURNAL OF MECHANICAL SCIENCES LA English DT Article AB Four different multimode optical fibers were tested to obtain the following correlations: (1) signal power with bend radius, (2) strain with bend radius and (3) signal power with strain. The data are presented numerically, graphically and mathematically. Graded index multimode and step index multimode fibers are discussed. The mechanism for the attenuation of light in optical fiber as a result of macrobending is examined. Three of the tested fibers demonstrated a consistent relationship between flexural strain and light transmissivity and could potentially be inlaid within a curved composite material system for use as the principal component in a stress or strain transducer. RP KIDD, JA (reprint author), USA,MAT TECHNOL LAB,MAT TESTING & EVALUAT BRANCH,WATERTOWN,MA 02172, USA. NR 7 TC 1 Z9 1 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0020-7403 J9 INT J MECH SCI JI Int. J. Mech. Sci. PY 1991 VL 33 IS 2 BP 101 EP 113 DI 10.1016/0020-7403(91)90060-G PG 13 WC Engineering, Mechanical; Mechanics SC Engineering; Mechanics GA FA943 UT WOS:A1991FA94300003 ER PT J AU KING, JW KASSEL, RJ AF KING, JW KASSEL, RJ TI DIMENSIONAL RESPONSE OF THE INTEGRATED MOLECULAR TRANSFORM SO INTERNATIONAL JOURNAL OF QUANTUM CHEMISTRY LA English DT Article ID TOPOLOGICAL INDEXES AB The integrated molecular transform provides a unitary chemical structure index that is useful in quantitative structure-activity/property studies. The transform is generated by a Fourier operation on any one of several different matrices of structure representation, e.g., adjacency, bond count, distance between bonded atoms (termed 2-dimensional [2-D]), and distance between all atoms in a molecule (termed 3-dimensional [3-D]). In this study, the integrated transforms based on bond count and 2-D and 3-D structure matrices have been generated and used to correlate an enthalpy function and heats of formation in a series of linear and branched hydrocarbons; these indices were also compared with the 3-D Wiener number and Randic branching indices for the series. For the linear regression model, the branching and 3-D Wiener indices correlate the enthalpy function best, but the 2-D molecular transform is most appropriate for heats of formation. A normalized linear model shows that the 3-D Wiener number and 2-D molecular transform are most appropriate for the former data, whereas the latter is most effectively correlated with the 2-D molecular transform. For reasons not clear, the 3-D molecular transform is a less suitable index for the noted thermodynamic functions in this series. C1 USA, CTR CHEM RES DEV & ENGN, ABERDEEN PROVING GROUND, MD 21010 USA. NR 16 TC 2 Z9 2 U1 0 U2 0 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0020-7608 EI 1097-461X J9 INT J QUANTUM CHEM JI Int. J. Quantum Chem. PY 1991 VL 40 SU 18 BP 289 EP 297 DI 10.1002/qua.560400726 PG 9 WC Chemistry, Physical; Mathematics, Interdisciplinary Applications; Physics, Atomic, Molecular & Chemical SC Chemistry; Mathematics; Physics GA GT389 UT WOS:A1991GT38900023 ER PT J AU ARMONDA, RA CARPENTER, MB AF ARMONDA, RA CARPENTER, MB TI DISTRIBUTION OF CHOLINERGIC PALLIDAL NEURONS IN THE SQUIRREL-MONKEY (SAIMIRI-SCIUREUS) BASED UPON CHOLINE-ACETYLTRANSFERASE SO JOURNAL FUR HIRNFORSCHUNG LA English DT Article DE CHOLINE ACETYLTRANSFERASE; GLOBUS PALLIDUS; STRIATUM; SUBSTANTIA INNOMINATA; SOMAL AREAS AND CELL MORPHOLOGY ID NUCLEUS BASALIS CH4; RAT NEOSTRIATUM; GLOBUS PALLIDUS; HUMAN-BRAIN; IMMUNOCYTOCHEMISTRY; ORGANIZATION; PROJECTIONS; INNERVATION; TERMINALS; FOREBRAIN AB The distribution of cells immunoreactive to choline acetyltransferase (ChAT-IR) in, and around the globus pallidus were studied in the squirrel monkey. Intrinsic pallidal ChAT-IR neurons in the globus pallidus were most numerous in ventrocaudal regions of the lateral pallidal segment (LPS) and in the oral pole of the medial pallidal segment (MPS). Smaller numbers of ChAT-positive cells were seen in portions of the medullary laminae of the pallidum. Computer measurements of somal areas of ChAT-IR cells in the globus pallidus, substantia innominata and putamen were made. Morphological features and somal areas of ChAT-IR cells in the globus pallidus and in the Ch4 group of the substantia innominata were strikingly similar. Cholinergic pallidal neurons appear to be part of the Ch4 cell group and have similar widespread cortical projections. The smaller cholinergic neurons in the striatum are considered to be intrinsic neurons which primarily act upon spiny striatal projection neurons. The possible local interaction of pallidal cholinergic neurons upon GABAergic neurons is unknown. C1 WALTER REED ARMY MED CTR,DEPT SURG,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,F EDWARD HEBERT SCH MED,DEPT ANAT,BETHESDA,MD 20814. RP CARPENTER, MB (reprint author), 4301 JONES BRIDGE RD,BETHESDA,MD 20814, USA. FU NINDS NIH HHS [NS-26658] NR 28 TC 3 Z9 3 U1 0 U2 0 PU AKADEMIE VERLAG GMBH PI BERLIN PA MUHLENSTRASSE 33-34, D-13187 BERLIN, GERMANY SN 0021-8359 J9 J HIRNFORSCH PY 1991 VL 32 IS 3 BP 357 EP 367 PG 11 WC Neurosciences SC Neurosciences & Neurology GA GU796 UT WOS:A1991GU79600007 PM 1779134 ER PT J AU BIRX, DL RHOADS, JL WRIGHT, JC BURKE, DS REDFIELD, RR AF BIRX, DL RHOADS, JL WRIGHT, JC BURKE, DS REDFIELD, RR TI IMMUNOLOGICAL PARAMETERS IN EARLY-STAGE HIV-SEROPOSITIVE SUBJECTS ASSOCIATED WITH VACCINE RESPONSIVENESS SO JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY LA English DT Article DE MULTIPLE VACCINE ANTIGENS; IMMUNOLOGICAL PARAMETERS; EARLY-STAGE HIV; T-CELLS; B-CELLS; FUNCTIONAL ASSAYS; VACCINE RESPONSE ID ACQUIRED IMMUNODEFICIENCY SYNDROME; IMMUNE-DEFICIENCY SYNDROME; B-CELL GROWTH; VIRUS-INFECTION; SYNDROME AIDS; ACTIVATION; DIFFERENTIATION; MONOCYTE; MACROPHAGES; SUPPRESSION AB Twenty-one asymptomatic HIV-seropositive subjects and 20 HIV-seronegative controls were assessed for their serologic response to multiple live attenuated viral, protein (toxoid), and polysaccharide vaccine antigens. Extensive in vivo and in vitro immunologic evaluations were performed. Factors predictive of immunogen responsiveness by HIV-seropositive patients were found by correlating vaccine responses with results of T- and B-cell functional assays. Eleven HIV-seropositive patients (HIV nonresponsive-NR) responded to only one of three vaccines used for analysis (meningococcus, group C; adenovirus 4, 7; and diphtheria-tetanus) compared with the normals, of whom 100% responded to two or more of the same immunogens. Ten HIV-seropositive patients (HIV responsive-R) responded equivalently to normals. The HIV NR group had distinctive immunologic abnormalities predictive of their poor immunogen responsiveness. These included defects in the T-cell helper function despite normalization of T cell number and defective T-cell suppression of Epstein-Barr virus (EBV) in vitro (HIV NR, 30% suppression; HIV R, 73% suppression; and normals, 95% suppression of EBV-driven immunoglobulin production in vitro). The B cells of the HIV NR groups were also abnormal in vivo. The HIV NR patients' B cells were larger and had increased native response to B-cell growth factor evidenced by increased thymidine incorporation. (HIV-NR, 10,232 +/- 3,003 cpm; HIV R, 5,432 +/- 1,125; normal, 402 +/- 11. HIV NR/HIV R, p < 0.05; HIV NR/N, p < 0.001). In addition, there was a significant increase in the production of spontaneous immunoglobulin within 24 h of culture in vitro in the HIV NR group [HIV NR, 279 (168,463); HIV R, 124 (27,214); normals, 7 (4,12), geometric mean of plaque-forming cells, 95% confidence intervals]. These in vitro abnormalities suggest significant immunologic dysregulation in early-stage asymptomatic HIV-infected patients. C1 WALTER REED ARMY MED CTR,DIV RETROVIROL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT MED,WASHINGTON,DC 20307. NR 35 TC 23 Z9 23 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 1077-9450 J9 J ACQ IMMUN DEF SYND JI J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. PY 1991 VL 4 IS 2 BP 188 EP 196 PG 9 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA EU101 UT WOS:A1991EU10100014 PM 1824786 ER PT J AU PHILLIPS, I HYAMS, KC MORAN, AY GOTUZZO, E SANCHEZ, J ROBERTS, CR AF PHILLIPS, I HYAMS, KC MORAN, AY GOTUZZO, E SANCHEZ, J ROBERTS, CR TI HTLV-I COINFECTION IN A HIV-1-INFECTED PERUVIAN POPULATION SO JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY LA English DT Letter ID CELL LEUKEMIA-VIRUS; HOMOSEXUAL MEN; INFECTION; TRINIDAD; AIDS; HIV C1 HOSP NACL GUILLERMO ALMENARA IRIGOYEN,LIMA,PERU. UNIV PERUANA CAYETANO HEREDIA,LIMA,PERU. WALTER REED ARMY MED CTR,SILVER SPRING,MD. RP PHILLIPS, I (reprint author), USN,MED RES INST DETACHMENT,LIMA,PERU. NR 9 TC 13 Z9 14 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 1077-9450 J9 J ACQ IMMUN DEF SYND JI J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. PY 1991 VL 4 IS 3 BP 301 EP 302 PG 2 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA EY269 UT WOS:A1991EY26900016 PM 1992107 ER PT J AU GENDELMAN, HE BACA, LM KUBRAK, C TURPIN, JA SILVERMAN, R FRIEDMAN, R MELTZER, MS AF GENDELMAN, HE BACA, LM KUBRAK, C TURPIN, JA SILVERMAN, R FRIEDMAN, R MELTZER, MS TI REGULATION OF IFN-ALPHA IN HIV-INFECTED CELLS - INVESTIGATIONS OF MECHANISMS OF ANTIVIRAL ACTIVITY AND IFN PRODUCTION SO JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,ROCKVILLE,MD. HENRY M JACKSON FDN,ROCKVILLE,MD. UNIFORMED SERV UNIV HLTH SCI,BETHESDA,MD 20814. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 1077-9450 J9 J ACQ IMMUN DEF SYND JI J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. PY 1991 VL 4 IS 3 BP 333 EP 333 PG 1 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA EY269 UT WOS:A1991EY26900081 ER PT J AU MAYERS, D MCCUTCHAN, FE SANDERSBUELL, E MERRITT, L FOWLER, AF RUIZ, NM BURKE, DS AF MAYERS, D MCCUTCHAN, FE SANDERSBUELL, E MERRITT, L FOWLER, AF RUIZ, NM BURKE, DS TI MOLECULAR CHARACTERIZATION OF HIV-1 VARIANTS ARISING AFTER PROLONGED ZIDOVUDINE (AZT) THERAPY SO JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY LA English DT Meeting Abstract C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. HENRY M JACKSON FDN,ROCKVILLE,MD. SRA LABS INC,ROCKVILLE,MD. NR 0 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 1077-9450 J9 J ACQ IMMUN DEF SYND JI J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. PY 1991 VL 4 IS 3 BP 343 EP 343 PG 1 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA EY269 UT WOS:A1991EY26900105 ER PT J AU WHITE, EL BUCKHEIT, RW PARKER, WB ROSS, LJ GERMANY, JM SHANNON, WM CHIRIGOS, MA AF WHITE, EL BUCKHEIT, RW PARKER, WB ROSS, LJ GERMANY, JM SHANNON, WM CHIRIGOS, MA TI TIBO DERIVATIVES ARE POTENT INHIBITORS OF HIV-1 REVERSE-TRANSCRIPTASE WITH HETEROPOLYMER TEMPLATES SO JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY LA English DT Meeting Abstract C1 USA,MED RES INST INFECT DIS,FREDERICK,MD 21701. SO RES INST,KETTERING MEYER LAB,BIRMINGHAM,AL 35255. NR 1 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 1077-9450 J9 J ACQ IMMUN DEF SYND JI J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. PY 1991 VL 4 IS 3 BP 359 EP 359 PG 1 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA EY269 UT WOS:A1991EY26900142 ER PT J AU DIGIOVANNI, C BERLIN, F CASTERELLA, P REDFIELD, RR HIKEN, M FALCK, A MALIN, HM GAGLIANO, S SCHAERF, F ROBERTS, C AF DIGIOVANNI, C BERLIN, F CASTERELLA, P REDFIELD, RR HIKEN, M FALCK, A MALIN, HM GAGLIANO, S SCHAERF, F ROBERTS, C TI PREVALENCE OF HIV ANTIBODY AMONG A GROUP OF PARAPHILIC SEX OFFENDERS SO JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY LA English DT Article DE PARAPHILIA; SEX OFFENDERS; SEXUAL BEHAVIOR; HIV PREVALENCE; HIV TRANSMISSION ID INFECTION; CHILD AB Serum specimens from 77 paraphilic sex offenders in treatment at a major community-based sexual disorders clinic were examined for human immunodeficiency virus (HIV) infection. In addition to their paraphilic ("sexually deviant") activities, most patients had also had nonparaphilic sexual contacts with consenting adult partners. These patients had engaged in a variety of sexual behaviors that involved real or potential exchange of body fluids. In spite of that fact, data analysis revealed that none of the 77 paraphilic patients was seropositive for HIV infection as assessed by recombinant enzyme-linked immunosorbent assay (ELISA). C1 WALTER REED ARMY MED CTR, DEPT RETROVIRAL RES, WASHINGTON, DC 20307 USA. WALTER REED ARMY MED CTR, DEPT DIAGNOST RETROVIROL, WASHINGTON, DC 20307 USA. JOHNS HOPKINS UNIV HOSP, DEPT PSYCHIAT, BALTIMORE, MD 21205 USA. USN HOSP, DEPT MED, OAKLAND, CA USA. RP DIGIOVANNI, C (reprint author), NATL NAVAL MED CTR, RETROVIRAL DIS STUDY GRP, BOX 1376, BETHESDA, MD 20814 USA. NR 10 TC 0 Z9 0 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 1077-9450 J9 J ACQ IMMUN DEF SYND JI J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. PY 1991 VL 4 IS 6 BP 633 EP 637 PG 5 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA FM102 UT WOS:A1991FM10200013 PM 2023104 ER PT J AU RHOADS, JL BIRX, DL WRIGHT, DC BRUNDAGE, JF BRANDT, BL REDFIELD, RR BURKE, DS AF RHOADS, JL BIRX, DL WRIGHT, DC BRUNDAGE, JF BRANDT, BL REDFIELD, RR BURKE, DS TI SAFETY AND IMMUNOGENICITY OF MULTIPLE CONVENTIONAL IMMUNIZATIONS ADMINISTERED DURING EARLY HIV-INFECTION SO JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY LA English DT Article DE IMMUNIZATIONS; HIV; IMMUNOGENICITY ID IMMUNE-DEFICIENCY SYNDROME; ACQUIRED IMMUNODEFICIENCY SYNDROME; LYMPHADENOPATHY-ASSOCIATED VIRUS; PERSISTENT GENERALIZED LYMPHADENOPATHY; ANTIBODY-RESPONSES; HOMOSEXUAL MEN; AIDS; INFLUENZA; DISEASE; ABNORMALITIES AB Twenty-one asymptomatic adults who had recently received multiple polysaccharide, live viral, and protein-derived vaccines were identified as being infected with human immunodeficiency virus (HIV). The mean subject age was 24 years (range 18-33); 20 of 21 (95%) were male. The mean T4 count was 523/mm3 with a mean T4/T8 ratio of 0.6. Serologic responses to immunization with meningococcus group C, adenovirus types 4 and 7, tetanus, and diphtheria were evaluated for the HIV seropositive subjects and were compared with the responses of similarly vaccinated age-, sex-, and race-matched HIV-seronegative controls. Significantly fewer (p < 0.03) HIV subjects responded to meningococcus C (bactericidal antibody) and adenovirus 4 (neutralizing antibody) vaccines than did normals; the HIV-infected subjects who did respond produced functional antibody comparable to that of normals. Booster responses of HIV subjects to tetanus and diphtheria were comparable to those of normals. HIV-infected vaccine nonresponders did not differ from HIV-infected responders in total white blood cell, T4, T4/T8, total serum IgG, or delayed-type hypersensitivity skin test reactivity. All HIV subjects had negative cultures for live vaccine viruses (rubella, measles, adenovirus, and poliovirus). Postimmunization, no clinically apparent adverse reactions to vaccination were detected. C1 WALTER REED ARMY MED CTR,DIV RETROVIROL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DIV PREVENT MED,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT MED,WASHINGTON,DC 20307. OI /0000-0002-5704-8094 NR 32 TC 12 Z9 12 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 1077-9450 J9 J ACQ IMMUN DEF SYND JI J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. PY 1991 VL 4 IS 7 BP 724 EP 731 PG 8 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA FR760 UT WOS:A1991FR76000011 PM 1675680 ER PT J AU MOULTON, JM STEMPEL, RR BACCHETTI, P TEMOSHOK, L MOSS, AR AF MOULTON, JM STEMPEL, RR BACCHETTI, P TEMOSHOK, L MOSS, AR TI RESULTS OF A ONE YEAR LONGITUDINAL-STUDY OF HIV ANTIBODY-TEST NOTIFICATION FROM THE SAN-FRANCISCO-GENERAL-HOSPITAL COHORT SO JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY LA English DT Article DE HIV; ANTIBODY TESTING; PSYCHOLOGICAL REACTIONS; ARC ID HOMOSEXUAL MEN; AIDS; GAY AB We examined the psychological impact of HIV antibody testing in 107 homosexual men in San Francisco. Seventy-eight percent of the seropositives but only 43% of the seronegatives correctly anticipated their results. Twelve months after notification (but not earlier), notified seropositives reported significantly greater increases in total distress than nonnotified controls. However, notified seronegatives demonstrated significantly lower levels of hopelessness than nonnotified controls at every follow-up assessment. Thus, knowledge of HIV antibody status appears to dispel a sense of gloom in persons who incorrectly believe themselves to be infected with HIV, but does not appear to induce significant distress in those whose expectation of a positive result is confirmed. Both groups reported lower distress than men with ARC or AIDS, suggesting that distress was related more to symptomatology than knowing antibody status. These results suggest the benefits of HIV testing for the considerable proportion of seronegative subjects believing themselves to be seropositive and should be weighted against the more limited induction of distress in seropositives who receive confirmation of their test result expectation. The benefits of testing are also supported by increasing knowledge of the usefulness of early intervention in HIV disease. C1 UNIV CALIF SAN FRANCISCO,DEPT EPIDEMIOL & BIOSTAT,SAN FRANCISCO,CA 94143. WALTER REED ARMY MED CTR,WALTER REED RETROVIRAL RES GRP,WASHINGTON,DC 20307. RP MOULTON, JM (reprint author), LETTERMAN ARMY MED CTR,DEPT PSYCHIAT,SAN FRANCISCO,CA 94129, USA. FU NIMH NIH HHS [1-T32 MH18261-01, MH 39344] NR 25 TC 22 Z9 22 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 1077-9450 J9 J ACQ IMMUN DEF SYND JI J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. PY 1991 VL 4 IS 8 BP 787 EP 794 PG 8 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA FX686 UT WOS:A1991FX68600008 PM 1856791 ER PT J AU LONGINI, IM CLARK, WS GARDNER, LI BRUNDAGE, JF AF LONGINI, IM CLARK, WS GARDNER, LI BRUNDAGE, JF TI THE DYNAMICS OF CD4+ LYMPHOCYTE-T DECLINE IN HIV-INFECTED INDIVIDUALS - A MARKOV MODELING APPROACH SO JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY LA English DT Article DE LYMPHOCYTES-T; STAGES OF INFECTION; NATURAL HISTORY; MARKOV MODEL; OPPORTUNISTIC INFECTION; INCUBATION PERIOD ID IMMUNODEFICIENCY VIRUS TYPE-1; UNITED-STATES-ARMY; AIDS; HEMOPHILIA; COUNTS; COHORT; EPIDEMIC; ADULTS; TIME AB We modeled the decline of CD4+ T-lymphocytes (T4 cells) in HIV-infected individuals with a continuous-time Markov process. The model partitions the HIV infection period into six progressive T4-cell count intervals (states), followed by a seventh state: a definitive HIV-infection end point, i.e., AIDS diagnosis or Walter Reed stage 6 (opportunistic infections). The Markov model was used to estimate the state-specific progression rates from data as functions of important progression cofactors. We applied the model to data on 1,796 HIV-positive individuals in the U.S. Army. The estimated mean waiting time from seroconversion to when the T4-cell count persistently drops below 500/mm3, but is greater than 349/mm3, is 4.1 years, and the waiting time to a T4-cell count of less than 200/mm3 is estimated at 8.0 years. The estimated rate of T4-cell decline was higher for HIV-infected individuals with initially high numbers of T4 cells, but the estimated rate of decline remains relatively uniform when the T4-cell count dropped persistently below 500/mm3. The opportunistic infection incubation period, i.e., the time from seroconversion to opportunistic infection diagnosis, is estimated at 9.6 years. Age is found to be an important cofactor. The estimated mean opportunistic infection incubation periods are 11.1, 10.0, and 8.9 years for the youngest (less-than-or-equal-to 25 years old), the middle (26-30 years old), and the oldest (greater-than-or-equal-to 30 years old) age groups, respectively. Moreover, we found that the rate of progression is the same for all three age groups when T4-cell counts are greater-than-or-equal-to 500/mm3, but it is faster for the two older age groups when T4-cell are < 500/mm3. C1 WALTER REED ARMY MED CTR,DEPT EPIDEMIOL,DIV PREVENT MED,WASHINGTON,DC 20307. RP LONGINI, IM (reprint author), EMORY UNIV,SCH PUBL HLTH,DIV BIOSTAT,ATLANTA,GA 30322, USA. NR 27 TC 112 Z9 114 U1 0 U2 2 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 1077-9450 J9 J ACQ IMMUN DEF SYND JI J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. PY 1991 VL 4 IS 11 BP 1141 EP 1147 PG 7 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA GN380 UT WOS:A1991GN38000010 PM 1684387 ER PT J AU MCCUTCHAN, FE SANDERSBUELL, E OSTER, CW REDFIELD, RR HIRA, SK PERINE, PL UNGAR, BLP BURKE, DS AF MCCUTCHAN, FE SANDERSBUELL, E OSTER, CW REDFIELD, RR HIRA, SK PERINE, PL UNGAR, BLP BURKE, DS TI GENETIC COMPARISON OF HUMAN-IMMUNODEFICIENCY-VIRUS (HIV-1) ISOLATES BY POLYMERASE CHAIN-REACTION SO JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY LA English DT Article DE PCR TYPING; HIV-1; GENETIC VARIATION ID NUCLEOTIDE-SEQUENCE; DIVERSITY; TYPE-1; AMPLIFICATION AB Amplification of DNA by polymerase chain reaction (PCR) is influenced by the homology of oligonucleotide primers with the DNA template. We have developed a procedure, termed anchored PCR, whereby nucleotide sequence alterations in the template can be directly related to the quantity of amplified product. Genetic variation in the human immunodeficiency virus HIV-1 has been studied using anchored PCR. In four field isolates of the virus, the 3'LTR was compared both by PCR analysis of DNA from virus cultures and DNA sequencing. DNA templates that matched the primers varied less than threefold in PCR product yield, whereas significant 3' end primer-template mispairing decreased PCR product 10- to 100-fold. Using these guidelines for genetic variability manifested through PCR, 40 PCR primers encompassing the GAG, ENV, and 3' LTR segments of the genome were used to compare sequential HIV-1 isolates from six patients. Some primers were apparently located in genomic regions without significant interisolate variability, as they yielded equivalent amounts of amplified DNA from all the isolates. The quantity of amplified DNA obtained with other primers varied 10- to 100-fold among patients, but was consistent for sequential isolates from an individual patients. Two African HIV-1 isolates were readily distinguished from a panel of North American isolates by the same method. Systematic classification of HIV-1 genetic variants may be possible by anchored PCR. C1 UNIV TEACHING HOSP,LUSAKA,ZAMBIA. UNIFORMED SERV UNIV HLTH SCI,DIV TROP PUBL HLTH,BETHESDA,MD 20814. WALTER REED ARMY MED CTR,DIV RETROVIROL,WASHINGTON,DC 20307. RP MCCUTCHAN, FE (reprint author), HENRY M JACKSON FDN ADVANCEMENT MIL MED RES LAB,1500 E GUDE DR,ROCKVILLE,MD 20850, USA. OI /0000-0002-5704-8094 NR 18 TC 24 Z9 24 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 1077-9450 J9 J ACQ IMMUN DEF SYND JI J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. PY 1991 VL 4 IS 12 BP 1241 EP 1250 PG 10 WC Immunology; Infectious Diseases SC Immunology; Infectious Diseases GA GR659 UT WOS:A1991GR65900010 PM 1941529 ER PT J AU KRAEMER, WJ PATTON, JF KNUTTGEN, HG HANNAN, CJ KETTLER, T GORDON, SE DZIADOS, JE FRY, AC FRYKMAN, PN HARMAN, EA AF KRAEMER, WJ PATTON, JF KNUTTGEN, HG HANNAN, CJ KETTLER, T GORDON, SE DZIADOS, JE FRY, AC FRYKMAN, PN HARMAN, EA TI EFFECTS OF HIGH-INTENSITY CYCLE EXERCISE ON SYMPATHOADRENAL-MEDULLARY RESPONSE PATTERNS SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE PROENKEPHALINS; OPIOID PEPTIDES; EPINEPHRINE; NOREPINEPHRINE; ANAEROBIC EXERCISE; SKELETAL MUSCLE MORPHOLOGY ID PROENKEPHALIN PEPTIDE-F; CATECHOLAMINE RESPONSES; PLASMA-CATECHOLAMINE; PROLONGED EXERCISE; BETA-ENDORPHIN; BLOOD LACTATE; EPINEPHRINE; ENKEPHALIN; ERGOMETER; CELLS AB Plasma proenkephalin peptide F immunoreactivity and catecholamines were examined on separate days in nine healthy males before and after maximal exercise to exhaustion at four intensities [36, 55, 73 and 100% of maximal leg power (MLP)] by use of a computerized cycle ergometer. The mean duration of 36, 55, 73, and 100% MLP was 3.31, 0.781, 0.270, and 0.1 min, respectively. All intensities were greater than those eliciting peak O2 uptake for the individual subjects. Blood samples were obtained before, immediately after exercise, and 5 and 15 min after exercise. Significant (P < 0.05) increases in plasma peptide F immunoreactivity (i.e., from mean resting value of 0.18 to 0.43 pmol/ml) were observed immediately after exercise at 36% MLP. Significant increases in plasma epinephrine were observed immediately after exercise at 36% MLP (i.e., from mean resting value of 2.22 to 3.11 pmol/ml) and 55% MLP (i.e., from mean resting value of 1.67 to 2.98 pmol/ml) and 15 min after exercise at 100% MLP (i.e., from mean resting value of 1.92 to 3.88 mpol/ml). Significant increases for plasma norepinephrine were observed immediately after exercise (36, 55, 73, and 100% MLP), 5 min after exercise (36, 55, and 73% MLP), and 15 min after exercise (36% MLP). Increases in whole blood lactate were observed in all points after exercise for 36, 55, and 73% MLP and 5 min after exercise for 100% MLP. These data show that brief high-intensity exercise results in differential response patterns of catecholamines and proenkephalin peptide F immunoreactivity. C1 USA,ENVIRONM MED RES INST,DIV EXERCISE PHYSIOL,NATICK,MA 01760. MADIGAN ARMY MED CTR,DEPT CLIN INVEST,TACOMA,WA 98431. RP KRAEMER, WJ (reprint author), PENN STATE UNIV,CTR SPORTS MED,GREENBERG SPORTS COMPLEX,UNIVERSITY PK,PA 16802, USA. NR 36 TC 28 Z9 28 U1 0 U2 2 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 8750-7587 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD JAN PY 1991 VL 70 IS 1 BP 8 EP 14 PG 7 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA ER676 UT WOS:A1991ER67600002 PM 2010413 ER PT J AU KNAPIK, J MEREDITH, C JONES, B FIELDING, R YOUNG, V EVANS, W AF KNAPIK, J MEREDITH, C JONES, B FIELDING, R YOUNG, V EVANS, W TI LEUCINE METABOLISM DURING FASTING AND EXERCISE SO JOURNAL OF APPLIED PHYSIOLOGY LA English DT Article DE LEUCINE FLUX; LEUCINE OXIDATION; UREA; PROTEIN TURNOVER; EXERTION ID KETO ACID DEHYDROGENASE; RAT SKELETAL-MUSCLE; AMINO-ACIDS; PROLONGED EXERCISE; FATTY-ACIDS; OXIDATION; HUMANS; GLUCOSE; PERFORMANCE; DIAPHRAGMS AB Whole body leucine kinetics were examined in seven healthy young men while in a 14-h postabsorptive state (PAS) and after a 3.5-day fast (FS). Subjects received a primed constant intravenous infusion of L-[1-C-13]leucine while resting for 3 h and then while exercising on a cycle ergometer at 45% maximal O2 uptake to exhaustion. Blood samples drawn during isotopic steady state were analyzed for C-13 enrichment of leucine and alpha-ketoisocaproic acid, and expired gas samples were analyzed for CO-2-(C-13). Resting leucine flux was higher in the FS, and there was a slight increase in leucine oxidation. During exercise, leucine flux did not differ between PAS and FS but leucine oxidation rose markedly. In the FS, leucine oxidation was 25 +/- 7 (SD)-mu-mol.kg-1.h-1 at rest and rose to 75 +/- 21-mu-mol.kg-1.h-1 during exercise; in the PAS, oxidation was 20 +/- 5-mu-mol.kg-1.h-1 at rest and 52 +/- 17-mu-mol.kg-1.h-1 during exercise. These data indicate that the high rate of leucine oxidation previously found during exercise was increased further by a 3.5-day fast. C1 MIT,CLIN RES CTR,CAMBRIDGE,MA 02139. TUFTS UNIV,USDA,HUMAN NUTR RES CTR AGING,BOSTON,MA 02111. SHRINERS BURN INST,BOSTON,MA 02114. RP KNAPIK, J (reprint author), USA,ENVIRONM MED RES INST,NATICK,MA 01760, USA. FU NCRR NIH HHS [RR-88]; NIDDK NIH HHS [DK-15856] NR 33 TC 41 Z9 43 U1 1 U2 5 PU AMER PHYSIOLOGICAL SOC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 8750-7587 J9 J APPL PHYSIOL JI J. Appl. Physiol. PD JAN PY 1991 VL 70 IS 1 BP 43 EP 47 PG 5 WC Physiology; Sport Sciences SC Physiology; Sport Sciences GA ER676 UT WOS:A1991ER67600006 PM 2010401 ER PT J AU DODD, KT GROSS, DR AF DODD, KT GROSS, DR TI 3-DIMENSIONAL TISSUE DEFORMATION IN SUBCUTANEOUS TISSUES OVERLYING BONY PROMINENCES MAY HELP TO EXPLAIN EXTERNAL LOAD-TRANSFER TO THE INTERSTITIUM SO JOURNAL OF BIOMECHANICS LA English DT Article ID FLUID PRESSURE; SORES; MODEL AB Anesthetized, carefully positioned, female, weanling, white-haired pigs were used to test the hypothesis that (1) interface pressure, the pressure between the skin and an external load, can be used to predict the interstitial fluid pressure over the wings of ilia and the last dorsal spinous process and (2) three-dimensional tissue deformation of the interstitium under the load could partially explain how the external load is transferred at that site. When a 4 or 8 kg load was distributed over the hips of the pigs, the interface pressures over the ilia were approximately 145 and 207 cm H2O, respectively. Approximately 28% of this pressure was transferred to the tissue, resulting in an increase in interstitial fluid pressure of approximately 39 cm H2O for the 4 kg load and 60 cm H2O for the 8 kg load. However, over the spinous process, about 42-43% of the load was transferred to the interstitium. Subcutaneous tissue marker movement occurred along the r and THETA spheircal coordinate but no significant tissue marker movement along the phi coordinate. The latter indicates no significant twisting of the tissue while the former demonstrates three-dimensional shearing. There were also indications of tissue creep since the markers continued to move with constant loading. C1 TEXAS A&M UNIV SYST,COLL VET MED,DEPT VET PHYSIOL,PHYSIOL & APPL PHYS LAB,COLLEGE STN,TX 77843. RP DODD, KT (reprint author), WALTER REED ARMY MED CTR,DIV MED,DEPT RESP RES,WASHINGTON,DC 20307, USA. FU NHLBI NIH HHS [NIHR 23-P-5788] NR 27 TC 9 Z9 9 U1 0 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0021-9290 J9 J BIOMECH JI J. Biomech. PY 1991 VL 24 IS 1 BP 11 EP 19 DI 10.1016/0021-9290(91)90322-E PG 9 WC Biophysics; Engineering, Biomedical SC Biophysics; Engineering GA FC285 UT WOS:A1991FC28500002 PM 2026630 ER PT J AU HARTMAN, AB RUIZ, MM SCHULTZ, CL AF HARTMAN, AB RUIZ, MM SCHULTZ, CL TI MOLECULAR ANALYSIS OF VARIANT PLASMID FORMS OF A BIVALENT SALMONELLA-TYPHI-SHIGELLA-SONNEI VACCINE STRAIN SO JOURNAL OF CLINICAL MICROBIOLOGY LA English DT Article ID ENTEROINVASIVE ESCHERICHIA-COLI; CUSTODIAL INSTITUTIONS; ANTIGEN GENES; DNA PROBES; IDENTIFICATION; INVASION; FLEXNERI; CHILDREN; SEQUENCE; PROTEIN AB The Salmonella typhi-Shigella sonnei hybrid vaccine strain 5076-1C was constructed to express the S. sonnei form I antigen, which may play an important role in producing protective immunity. Three clonal variants which existed in preparations of the vaccine could be distinguished phenotypically by lactose utilization, S. sonnei form I antigen expression, and restriction enzyme analysis of large plasmid DNA. Since expression of the form I antigen was lost in two of the clonal variants, genetic instability of the 120-MDa vaccine plasmid appeared to be a potential problem. To examine the molecular basis of this genetic instability, we hybridized large plasmid DNA isolated from the clonal variants to a varity of DNA probes encoding virulence-associated antigens and Escherichia coli lacZ DNA. Results indicated that DNA rearrangements accompanied by deletions of plasmid material occurred in the vaccine plasmid. In addition, the vaccine plasmid did not contain some S. sonnei genetic material encoding antigenic polypeptides necessary for virulence. C1 WALTER REED ARMY MED CTR,DEPT CELLULAR IMMUNOL,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DIV COMMUNICABLE DIS & IMMUNOL,WASHINGTON,DC 20307. RP HARTMAN, AB (reprint author), WALTER REED ARMY MED CTR,DEPT BIOL RES,WASHINGTON,DC 20307, USA. NR 35 TC 14 Z9 14 U1 0 U2 0 PU AMER SOC MICROBIOLOGY PI WASHINGTON PA 1325 MASSACHUSETTS AVENUE, NW, WASHINGTON, DC 20005-4171 SN 0095-1137 J9 J CLIN MICROBIOL JI J. Clin. Microbiol. PD JAN PY 1991 VL 29 IS 1 BP 27 EP 32 PG 6 WC Microbiology SC Microbiology GA EP044 UT WOS:A1991EP04400006 PM 1993762 ER PT J AU POLE, JG CASPER, J ELFENBEIN, G GEE, A GROSS, S JANSSEN, W KOCH, P MARCUS, R PICK, T SHUSTER, J SPRUCE, W THOMAS, P YEAGER, A AF POLE, JG CASPER, J ELFENBEIN, G GEE, A GROSS, S JANSSEN, W KOCH, P MARCUS, R PICK, T SHUSTER, J SPRUCE, W THOMAS, P YEAGER, A TI HIGH-DOSE CHEMORADIOTHERAPY SUPPORTED BY MARROW INFUSIONS FOR ADVANCED NEUROBLASTOMA - A PEDIATRIC ONCOLOGY GROUP-STUDY SO JOURNAL OF CLINICAL ONCOLOGY LA English DT Article ID ADVANCED NEURO-BLASTOMA; BONE-MARROW; AUTOLOGOUS MARROW; SOLID TUMORS; TRANSPLANTATION; RADIATION; CHILDREN; CYCLOPHOSPHAMIDE; CISPLATIN C1 UNIV S FLORIDA, TAMPA, FL 33620 USA. BAXTER HLTH CORP, SANTA ANA, CA USA. MIDWEST CHILDRENS CANC CTR, MILWAUKEE, WI USA. UNIV CALIF SAN DIEGO, CHILDRENS HOSP & HLTH CTR, SAN DIEGO, CA 92103 USA. BROOKE ARMY MED CTR, FT SAM HOUSTON, TX 78234 USA. JOHNS HOPKINS UNIV, BALTIMORE, MD 21218 USA. UNIV TEXAS SAN ANTONIO, SAN ANTONIO, TX 78285 USA. MCGILL UNIV, MONTREAL H3A 1A1, QUEBEC, CANADA. RP POLE, JG (reprint author), UNIV FLORIDA, PEDIAT ONCOL GRP, 4949 W PINE BLVD, SUITE 2A, ST LOUIS, MO 63108 USA. OI Janssen, William/0000-0001-5066-9608 FU NCI NIH HHS [CA-32053, CA-29281, CA-33587] NR 34 TC 47 Z9 47 U1 0 U2 0 PU AMER SOC CLINICAL ONCOLOGY PI ALEXANDRIA PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA SN 0732-183X EI 1527-7755 J9 J CLIN ONCOL JI J. Clin. Oncol. PD JAN PY 1991 VL 9 IS 1 BP 152 EP 158 PG 7 WC Oncology SC Oncology GA EP763 UT WOS:A1991EP76300021 PM 1985165 ER PT J AU Sheth, PN Craig, KC Mattice, M Banks, S AF Sheth, Pradip N. Craig, Kevin C. Mattice, Michael Banks, Steven TI Design and Development of a Computer-aided Engineering Environment for Controlled Multibody Systems SO JOURNAL OF ENGINEERING DESIGN LA English DT Article AB A computer-aided engineering (CAE) environment for the design and analysis of computer-controlled multibody systems is defined, and a prototype environment is demonstrated in this paper. The overall integrated environment includes systems for three-dimensional geomenic modeling and animation, multibody system dynamics, finite element analysis, and control system design. In this paper, the integration of a multibody system dynamics program IMP with the control system design program MATRIXx is demonstrated. Transfer functions from the multibody system model, together with mathematical models of any electrical, pneumatic and hydraulic components, are used in MATRIXx for control system synthesis. The controller architecture and parameters are specified in block diagram form and convened to a real-time program through an automatic code generator in MATRIXx. This program is downloaded to a microprocessor for controlling the actual, physical plant. In the CAE environment of this paper, the controller program, with any non-mechanical component models included, is combined with the original IMP non-linear mechanical system model. The dynamic response of this complete system is studied to verify the controller design for this non-linear, more realistic mechanical model. C1 [Sheth, Pradip N.] Univ Virginia, Dept Mech & Aerosp Engn, Charlottesville, VA 22901 USA. [Craig, Kevin C.] Rensselaer Polytech Inst, Dept Mech Engn Aeronaut Engn & Mech, Troy, NY 12181 USA. [Mattice, Michael; Banks, Steven] USA, ARDEC, Automat & Robot Team, Picatinny Arsenal, NJ 07806 USA. RP Sheth, PN (reprint author), Univ Virginia, Dept Mech & Aerosp Engn, Charlottesville, VA 22901 USA. NR 13 TC 0 Z9 0 U1 0 U2 1 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0954-4828 J9 J ENG DESIGN JI J. Eng. Des. PY 1991 VL 2 IS 3 BP 175 EP 195 DI 10.1080/09544829108901680 PG 21 WC Engineering, Multidisciplinary SC Engineering GA V11UE UT WOS:000207555700002 ER PT J AU BARATTA, FI PERRONE, PJ AF BARATTA, FI PERRONE, PJ TI A METHOD FOR DYNAMIC FRACTURE INITIATION TESTING OF CERAMICS - DISCUSSION SO JOURNAL OF ENGINEERING MATERIALS AND TECHNOLOGY-TRANSACTIONS OF THE ASME LA English DT Discussion C1 GE,AIRCRAFT ENGINES,LYNN,MA 01905. RP BARATTA, FI (reprint author), USA,MAT TECHNOL LAB,WATERTOWN,MA 02172, USA. NR 9 TC 1 Z9 1 U1 0 U2 0 PU ASME-AMER SOC MECHANICAL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017 SN 0094-4289 J9 J ENG MATER-T ASME JI J. Eng. Mater. Technol.-Trans. ASME PD JAN PY 1991 VL 113 IS 1 BP 183 EP 185 DI 10.1115/1.2903376 PG 3 WC Engineering, Mechanical; Materials Science, Multidisciplinary SC Engineering; Materials Science GA FE819 UT WOS:A1991FE81900025 ER PT J AU SHIVER, FC NELSON, MS NELSON, LK AF SHIVER, FC NELSON, MS NELSON, LK TI NONDESTRUCTIVE DIFFERENTIATION OF FULL-COLOR PHOTOCOPIES SO JOURNAL OF FORENSIC SCIENCES LA English DT Article DE QUESTIONED DOCUMENTS; PHOTOCOPIERS; CYLITHOGRAPHIC; LASER AB There has been a recent increase in the use and availability of full-color copiers. With this increase comes a greater potential for criminal use. Research by the authors has shown that many products of full-color copiers can be differentiated by the use of microscopy, infrared luminescence, infrared reflectance, and laser luminescence. RP SHIVER, FC (reprint author), USA,CRIMINAL INVEST LAB,FT GILLEM,FOREST PK,GA 30050, USA. NR 7 TC 6 Z9 6 U1 0 U2 0 PU AMER SOC TESTING MATERIALS PI W CONSHOHOCKEN PA 100 BARR HARBOR DR, W CONSHOHOCKEN, PA 19428-2959 SN 0022-1198 J9 J FORENSIC SCI JI J. Forensic Sci. PD JAN PY 1991 VL 36 IS 1 BP 145 EP 152 PG 8 WC Medicine, Legal SC Legal Medicine GA FJ853 UT WOS:A1991FJ85300022 ER PT J AU SMITH, BC AF SMITH, BC TI CHANGES IN PERIKYMATA AND THEIR SIGNIFICANCE TO A POSTMORTEM DENTAL IDENTIFICATION SO JOURNAL OF FORENSIC SCIENCES LA English DT Article DE ODONTOLOGY; PERIKYMATA; HUMAN IDENTIFICATION AB Perikymata are wavelike features that are normally found in the surface enamel of teeth. These structures are known to undergo regressive changes due to gradual attrition, mechanical abrasion, or chemical erosion. Forensic science has suggested that significance be placed on some forms of their loss as indicators of age, oral habits, and alignment of individual teeth. The dental identification of victims of a Vietnam War military aircraft crash is presented. The unusual pattern of perikymata change on two of the teeth suggests the antemortem existence of a removable partial denture. These findings support the exclusionary conclusions. C1 USA,IDENTIFICAT LAB,FT SHAFTER,HI. NR 11 TC 2 Z9 2 U1 0 U2 1 PU AMER SOC TESTING MATERIALS PI W CONSHOHOCKEN PA 100 BARR HARBOR DR, W CONSHOHOCKEN, PA 19428-2959 SN 0022-1198 J9 J FORENSIC SCI JI J. Forensic Sci. PD JAN PY 1991 VL 36 IS 1 BP 166 EP 178 PG 13 WC Medicine, Legal SC Legal Medicine GA FJ853 UT WOS:A1991FJ85300024 PM 2007866 ER PT J AU DAILEY, JC AF DAILEY, JC TI THE IDENTIFICATION OF FRAGMENTED VIETNAM-WAR REMAINS UTILIZING A HEALING EXTRACTION SITE SO JOURNAL OF FORENSIC SCIENCES LA English DT Article DE ODONTOLOGY; HUMAN IDENTIFICATION AB A difficult dental identification of fragmented Vietnam War remains was made without the benefit of roentgenogram comparisons. The identification was strengthened by the highly unusual finding of a healing extraction site. RP DAILEY, JC (reprint author), USA,DENT ACTIV,WILLIAM BEAUMONT ARMY MED CTR,FT BLISS,TX 79920, USA. NR 4 TC 7 Z9 7 U1 0 U2 0 PU AMER SOC TESTING MATERIALS PI W CONSHOHOCKEN PA 100 BARR HARBOR DR, W CONSHOHOCKEN, PA 19428-2959 SN 0022-1198 J9 J FORENSIC SCI JI J. Forensic Sci. PD JAN PY 1991 VL 36 IS 1 BP 264 EP 271 PG 8 WC Medicine, Legal SC Legal Medicine GA FJ853 UT WOS:A1991FJ85300035 PM 2007876 ER PT J AU GILBERT, PA AF GILBERT, PA TI RAPID WATER-CONTENT BY COMPUTER-CONTROLLED MICROWAVE DRYING SO JOURNAL OF GEOTECHNICAL ENGINEERING-ASCE LA English DT Article AB Equipment for determining water content rapidly, accurately, and reliably is required to properly monitor the compaction of earth fills. Improper compaction control can result in structures with severe performance and maintenance problems. Water content determination in a conventional oven may require up to 24 hr. If 24 hr are required to determine that the water content of a layer is unacceptable, that layer may be buried under several feet of subsequently placed and compacted fill. This paper describes a microwave drying system developed to determine water content reliably and accurately in real time. The design of the system is based on continuously monitoring the weight change of a soil specimen subjected to microwave radiation. The system, its theory of operation, and its use are described briefly. Data are presented to show that microwave and conventional water contents usually correlate to within half a percentage point for a variety of soils. The microwave system has been satisfactorily used on two Corps of Engineers filed projects. Analysis of data from the projects is presented. RP GILBERT, PA (reprint author), USA,WATERWAYS EXPT STN,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 17 TC 1 Z9 1 U1 0 U2 1 PU ASCE-AMER SOC CIVIL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-9410 J9 J GEOTECH ENG-ASCE JI J. Geotech. Eng.-ASCE PD JAN PY 1991 VL 117 IS 1 BP 118 EP 138 DI 10.1061/(ASCE)0733-9410(1991)117:1(118) PG 21 WC Engineering, Civil; Geosciences, Multidisciplinary SC Engineering; Geology GA EQ058 UT WOS:A1991EQ05800008 ER PT J AU COLBECK, SC WARREN, GC AF COLBECK, SC WARREN, GC TI THE THERMAL RESPONSE OF DOWNHILL SKIS SO JOURNAL OF GLACIOLOGY LA English DT Article AB The temperatures in downhill skies were measured with thermocouples to investigate the heat generation associated with the sliding of skis on snow. In these tests we investigated the effects on ski temperature of the ambient snow temperature, snow type, speed, load and thermal conductivity. A significant temperature rise at the base of the ski was found at the onset of motion in all runs. The temperature rise increased for heavier loads and at lower ambient temperatures. Some ski runs lasted long enough to observe a steady-state temperature at the ski base; it increased with ambient temperature. Longitudinal and transverse temperature variations occurred and were sensitive to snow hardness and skiing technique. We also investigated heat flow through the cross-section of the ski with a finite-element model to determine the effects of ski structure on heat retention at the base. We found that the thermal characteristics as determined by the structure of the ski had a significant effect on the temperature at the ski base. At lower temperatures we expect that friction will be greater in skis which have a large aluminum plate across their base. Steel edges have a lesser effect. C1 DARTMOUTH COLL,THAYER SCH ENGN,HANOVER,NH 03755. RP COLBECK, SC (reprint author), USA,COLD REG RES & ENGN LAB,HANOVER,NH 03755, USA. NR 12 TC 11 Z9 11 U1 0 U2 4 PU INT GLACIOL SOC PI CAMBRIDGE PA LENSFIELD RD, CAMBRIDGE, ENGLAND CB2 1ER SN 0022-1430 J9 J GLACIOL JI J. Glaciol. PY 1991 VL 37 IS 126 BP 228 EP 235 PG 8 WC Geography, Physical; Geosciences, Multidisciplinary SC Physical Geography; Geology GA GW524 UT WOS:A1991GW52400005 ER PT J AU JOHNSON, JB AF JOHNSON, JB TI SIMPLE-MODEL OF SHOCK-WAVE ATTENUATION IN SNOW SO JOURNAL OF GLACIOLOGY LA English DT Article AB A simple momentum model, assuming that snow compacts along a prescribed pressure-density curve, is used to calculate the pressure attenuation of shock waves in snow. Four shock-loading situations are examined: instantaneously applied pressure impulses for one-dimensional, cylindrical and spherical shock-wave geometries, and a one-dimensional pressure impulse of finite duration. Calculations show that for an instantaneously applied impulse the pressure attenuation for one-dimensional, cylindrical and spherical shock waves is determined by the pressure density (P-rho) compaction curve of snow. The maximum attenuation for a one-dimensional shock wave is proportional to (X(f) - X0)-1.5 for the multi-stage (P - rho) curve and (X(f) - X0)-2 when compaction occurs in a single step (single-stage compaction), where (X(f) - X0) is the shock-wave propagation distance. Cylindrical waves have a maximum attentuation that varies from (R - R0)-2 for single-stage compaction and (R - R0)-1.5 for multi-stage compaction, when (R - R0) << R0, where R is the propagation radius and R0 is the interior radius over which a pressure impulse is applied, to R-4 when (R - R0) >> R0. Spherical waves have a maximum attentuation that varies from (R - R0)-2 for single-stage compaction and (R - R0)-1.5 for multi-stage compaction to R-6 when >> R0. The shock-wave pressure in snow for a finite-duration pressure impulse is determined by the pressure impulse versus time profile during the time interval of the impulse. After the pressure impulse ends, shock-wave pressure attentuation is the same as for an instantaneously applied pressure impulse containing the same total momentum. Pressure attentuation near a shock-wave source, where the duration of the shock wave is relatively short, is greater than for a shock wave farther from a source where the shock wave has a relatively long duration. Shock-wave attenutation in snow can be delayed or reduced by increasing the duration of a finite-duration pressure impulse. A sufficiently long-duration impulse may result in no shock-wave pressure attenuation in a shallow snow cover. RP JOHNSON, JB (reprint author), USA,COLD REG RES & ENGN LAB,FT WAINWRIGHT,AK 99703, USA. NR 12 TC 2 Z9 2 U1 0 U2 0 PU INT GLACIOL SOC PI CAMBRIDGE PA LENSFIELD RD, CAMBRIDGE, ENGLAND CB2 1ER SN 0022-1430 J9 J GLACIOL JI J. Glaciol. PY 1991 VL 37 IS 127 BP 303 EP 312 PG 10 WC Geography, Physical; Geosciences, Multidisciplinary SC Physical Geography; Geology GA HA222 UT WOS:A1991HA22200001 ER PT J AU STURM, M HALL, DK BENSON, CS FIELD, WO AF STURM, M HALL, DK BENSON, CS FIELD, WO TI NON-CLIMATIC CONTROL OF GLACIER-TERMINUS FLUCTUATIONS IN THE WRANGELL AND CHUGACH MOUNTAINS, ALASKA, USA SO JOURNAL OF GLACIOLOGY LA English DT Article ID VARIEGATED GLACIER; SURGE; FLOW AB Fluctuations of glacier termini were studied in two regions in Alaska. In the Wrangell Mountains, 15 glaciers on Mount Wrangell, an active volcano, have been monitored over the past 30 years by surveying, photogrammetry and satellite. Results, which are consistent between different methods of measurement, indicate that the termini of most glaciers were stationary or retreating slightly. However, the termini of the 30 km long Ahtna Glacier and the smaller Center and South MacKeith Glaciers began to advance in the early 1960s and have advanced steadily between 5 and 18 m a-1 since then. These three glaciers flow from the active North Crater, where increased volcanic heating since 1964 has melted over 7 x 10(7) m3 of ice. We suspect that volcanic meltwater has changed the basal conditions for the three glaciers, resulting in their advance. The terminus fluctuations of six tide-water and near-tide-water glaciers in College Fjord, Prince William Sound, have been monitored since 1931 by surveying, photogrammetry and, most recently, by satellite imagery. Harvard Glacier, a 40 km long tide-water glacier, has been advancing at an average rate of nearly 20 m a-1 since 1931, while the adjacent Yale Glacier has retreated at approximately 50 m a-1 during the same period though, for short periods, both of these rates have been much higher. The striking contrast between the terminus behavior of Yale and Harvard Glaciers, which parallel each other in the same fiord, and are derived from the same snowfield, supports the hypothesis that their terminus behavior is largely the result of dynamic controls rather than changes in climate. C1 NASA,GODDARD SPACE FLIGHT CTR,GREENBELT,MD 20771. UNIV ALASKA,INST GEOPHYS,FAIRBANKS,AK 99775. AMER GEOG SOC,NEW YORK,NY. RP STURM, M (reprint author), USA,COLD REG RES & ENGN LAB,FT WAINWRIGHT,AK 99703, USA. RI Hall, Dorothy/D-5562-2012 NR 49 TC 19 Z9 19 U1 0 U2 3 PU INT GLACIOL SOC PI CAMBRIDGE PA LENSFIELD RD, CAMBRIDGE, ENGLAND CB2 1ER SN 0022-1430 J9 J GLACIOL JI J. Glaciol. PY 1991 VL 37 IS 127 BP 348 EP 356 PG 9 WC Geography, Physical; Geosciences, Multidisciplinary SC Physical Geography; Geology GA HA222 UT WOS:A1991HA22200007 ER PT J AU HOWELL, GL MELBY, JA AF HOWELL, GL MELBY, JA TI STOCHASTIC ESTIMATION OF EXTREME STRESSES IN BREAKWATER CONCRETE ARMOR UNITS SO JOURNAL OF HYDRAULIC RESEARCH LA English DT Article AB Safe design of breakwater concrete armor units requires design values for the maximum stress which will occur in the prototype. Traditional structural analysis techniques require deterministic definitions of boundary conditions and loads. Random placement of units results in random boundary conditions and random static loads. Forces due to waves are random due to the distribution of wave heights and the random drag profiles of the units. Estimation of stresses due to unit motion and the resulting impact forces requires stochastic methods. Using statistical analysis of stresses in dolos armor units measured at prototype scale at Crescent City, California, stochastic models have been developed which describe the observed response. The static, wave force, and impact loads are separate, but dependent populations. Techniques to combine the estimates into a single design stress probability distribution are demonstrated. With a combined exceedance probability distribution function and a design safety factor, the designer can estimate a single design stress value for input to traditional structural design procedures. The stochastic methods may be applied as easily as design formulas when implemented on a desktop computer. RP HOWELL, GL (reprint author), USA,COASTAL ENGN RES CTR,WATERWAYS EXPT STN,VICKSBURG,MS 39180, USA. NR 23 TC 0 Z9 0 U1 1 U2 1 PU INT ASSN HYDRAULIC RESEARCH PI DELFT PA PO BOX 177, 2600 DELFT, NETHERLANDS SN 0022-1686 J9 J HYDRAUL RES JI J. Hydraul. Res. PY 1991 VL 29 IS 6 BP 801 EP 814 PG 14 WC Engineering, Civil; Water Resources SC Engineering; Water Resources GA GY872 UT WOS:A1991GY87200007 ER PT J AU KALTER, DC NAKAMURA, M TURPIN, JA BACA, LM HOOVER, DL DIEFFENBACH, C RALPH, P GENDELMAN, HE MELTZER, MS AF KALTER, DC NAKAMURA, M TURPIN, JA BACA, LM HOOVER, DL DIEFFENBACH, C RALPH, P GENDELMAN, HE MELTZER, MS TI ENHANCED HIV REPLICATION IN MACROPHAGE COLONY-STIMULATING FACTOR-TREATED MONOCYTES SO JOURNAL OF IMMUNOLOGY LA English DT Article ID HUMAN IMMUNODEFICIENCY VIRUS; TUMOR NECROSIS FACTOR; MONONUCLEAR PHAGOCYTES; PERIPHERAL-BLOOD; FACTOR-ALPHA; MOLECULAR-CLONING; GENE-EXPRESSION; LYMPHOCYTES-T; GROWTH-FACTOR; FACTOR CSF-1 AB Monocytes cultured 7 to 10 days in recombinant human macrophage CSF (MCSF) were > 400-fold more susceptible to HIV infection than an equal number of cells cultured in medium alone. Levels of reverse transcriptase activity and p24 Ag in culture fluids of monocytes treated with MCSF 1 wk before and continuously after HIV infection were significantly greater than those of control cells cultured without MCSF. HIV-induced cytopathic effects in the MCSF-treated cultures also increased in both frequency and extent. At any given viral inoculum, the frequency of HIV-infected cells, the level of HIV mRNA/infected cell, and the level of proviral DNA/infected culture in MCSF-treated monocyte cultures were dramatically greater than those in control cultures. These differences were directly related to MCSF concentration to a maximum between 750 and 1000 U/ml MCSF, and were evident at all time points examined through 5 wk. None of the preceding effects was observed when MCSF was added at the time of or 1 wk after HIV infection. These data suggest that the predominant effect of MCSF for control of HIV infection is on the monocyte itself, not the virus. If these in vitro observations extend to the HIV-infected patient, then the variable levels of MCSF in tissue or blood may determine both the susceptibility of macrophages to virus infection and the extent of virus replication in infected cells. C1 WALTER REED ARMY MED CTR,DEPT CELLULAR IMMUNOL,HIV IMMUNOPATHOGENESIS PROGRAM,WASHINGTON,DC 20307. HENRY M JACKSON FDN ADV MIL MED,ROCKVILLE,MD 20850. UNIFORMED SERV UNIV HLTH SCI,DEPT PATHOL,BETHESDA,MD 20814. CETUS CORP,DEPT CELL BIOL,EMERYVILLE,CA 94608. NR 57 TC 129 Z9 130 U1 0 U2 0 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD JAN 1 PY 1991 VL 146 IS 1 BP 298 EP 306 PG 9 WC Immunology SC Immunology GA EQ340 UT WOS:A1991EQ34000048 PM 1701795 ER PT J AU STAPLETON, JT LANGE, DK LEDUC, JW BINN, LN JANSEN, RW LEMON, SM AF STAPLETON, JT LANGE, DK LEDUC, JW BINN, LN JANSEN, RW LEMON, SM TI THE ROLE OF SECRETORY IMMUNITY IN HEPATITIS-A VIRUS-INFECTION SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID NEUTRALIZING ANTIBODY; CELL-CULTURES; VACCINE; ASSAY; SERUM; MARMOSETS; SALIVA; STRAIN; LIVER AB Because the role of intestinal immunity remains uncertain in hepatitis A, samples of feces and saliva from infected primates and humans were tested for virus neutralizing activity. Only two of eight owl monkeys infected by the intragastric route developed neutralizing antibody detectable in extracts of feces collected up to 88 days after viral challenge, although serum neutralizing antibody was present in all monkeys by day 33. Similarly, neutralizing antibody was detected in fecal extracts from none of three experimentally infected human volunteers and only 1 of 15 naturally infected humans. The single positive human specimen contained occult blood. Only 2 of 19 saliva samples from naturally infected humans had significant viral neutralizing activity. In contrast, neutralizing antibody to type 2 poliovirus was present in most human fecal or saliva specimens tested. These data suggest that intestinal immunity does not play a significant role in protection against hepatitis A. C1 VET ADM MED CTR,DEPT INTERNAL MED,IOWA CITY,IA 52240. USA,MED RES INST INFECT DIS,FREDERICK,MD 21701. WALTER REED ARMY MED CTR,DEPT VIRUS DIS,WASHINGTON,DC 20307. UNIV N CAROLINA,SCH MED,DEPT MED,DIV INFECT DIS,CHAPEL HILL,NC 27514. RP STAPLETON, JT (reprint author), UNIV IOWA,COLL MED,DEPT INTERNAL MED,DIV INFECT DIS,IOWA CITY,IA 52242, USA. NR 28 TC 33 Z9 33 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD JAN PY 1991 VL 163 IS 1 BP 7 EP 11 PG 5 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA EP678 UT WOS:A1991EP67800002 PM 1845810 ER PT J AU JOHNSON, SC CHUNG, RCY DEAL, CD BOSLEGO, JW SADOFF, JC WOOD, SW BRINTON, CC TRAMONT, EC AF JOHNSON, SC CHUNG, RCY DEAL, CD BOSLEGO, JW SADOFF, JC WOOD, SW BRINTON, CC TRAMONT, EC TI HUMAN IMMUNIZATION WITH PGH 3-2 GONOCOCCAL PILUS RESULTS IN CROSS-REACTIVE ANTIBODY TO THE CYANOGEN-BROMIDE FRAGMENT-2 OF PILIN SO JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID NEISSERIA-GONORRHOEAE; POLYMORPHONUCLEAR LEUKOCYTES; PROTEINS; ADHESION; NITROCELLULOSE; IDENTIFICATION; INFECTION; VACCINE AB In 1983, a gonococcal pilus vaccine failed to show protection in a large, placebo-controlled, double-blind field trial. The epitopic response to this vaccine was investigated in a random sub-group of 20 vaccine recipients. Using Western blot analysis of the immunizing pilus and its cyanogen bromide (CNBr) fragments, IgG antibody to pilin was detected before immunization in all individuals. Preexistent antibody to the CNBr-2 and CNBr-3 fragments of pilin was detected in 65% and 5% of individuals, respectively. Pilus immunization resulted in a vigorous response to the CNBr-2 fragment in 100% of the individuals tested; only 33% developed antibody to the CNBr-3 fragment. Absorptions of postimmunization sera with different gonococcal strains resulted in either complete or partial removal of antibody to the CNBr-2 fragment. In the context of an unsuccessful vaccine trial, these results suggest that antibody to the CNBr-2 fragment of pilin may not be protective. C1 WALTER REED ARMY MED CTR,DEPT BACTERIAL DIS,WASHINGTON,DC 20307. UNIV PITTSBURGH,DEPT BIOL SCI,PITTSBURGH,PA 15260. RP JOHNSON, SC (reprint author), WALTER REED ARMY MED CTR,DEPT MED,SERV INFECT DIS,WASHINGTON,DC 20307, USA. NR 31 TC 19 Z9 21 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0022-1899 J9 J INFECT DIS JI J. Infect. Dis. PD JAN PY 1991 VL 163 IS 1 BP 128 EP 134 PG 7 WC Immunology; Infectious Diseases; Microbiology SC Immunology; Infectious Diseases; Microbiology GA EP678 UT WOS:A1991EP67800022 PM 1701817 ER PT J AU MEREISH, KA MORRIS, S MCCULLERS, G TAYLOR, TJ BUNNER, DL AF MEREISH, KA MORRIS, S MCCULLERS, G TAYLOR, TJ BUNNER, DL TI ANALYSIS OF PALYTOXIN BY LIQUID-CHROMATOGRAPHY AND CAPILLARY ELECTROPHORESIS SO JOURNAL OF LIQUID CHROMATOGRAPHY LA English DT Article ID CARBOXYLIC-ACID; TOXIN AB Palytoxin (PTX) a non-protein molecule extracted from soft coral of the genus Palythoa is the most poisonous marine toxin known to date. We have established high-performance-capillary electrophoresis (HPCE) and liquid-chromatography (HPLC) methods for the analysis of PTX. The detection limit of the HPLC method was 125 ng/injection. The sensitivity of the HPCE method was 0.5 pg/injection, several times greater than the HPLC method. The detection sensitivity at 230 nm was two fold higher than that at 263 nm. The sample analysis time for both methods was about the same (10 min). The development of an HPCE method will allow the measurement of PTX at low concentrations in small sample volumes, which was not possible by HPLC. C1 BECKMAN INSTRUMENTS INC,COLUMBIA,MD 21045. RP MEREISH, KA (reprint author), USA,MED RES INST INFECT DIS,FT DETRICK,FREDERICK,MD 21702, USA. NR 7 TC 7 Z9 9 U1 0 U2 0 PU MARCEL DEKKER INC PI NEW YORK PA 270 MADISON AVE, NEW YORK, NY 10016 SN 0148-3919 J9 J LIQ CHROMATOGR JI J. Liq. Chromatogr. PY 1991 VL 14 IS 5 BP 1025 EP 1031 DI 10.1080/01483919108049302 PG 7 WC Biochemical Research Methods; Chemistry, Analytical SC Biochemistry & Molecular Biology; Chemistry GA FL642 UT WOS:A1991FL64200013 ER PT J AU BEAMAN, JR TURELL, MJ AF BEAMAN, JR TURELL, MJ TI TRANSMISSION OF VENEZUELAN EQUINE ENCEPHALOMYELITIS VIRUS BY STRAINS OF AEDES-ALBOPICTUS (DIPTERA, CULICIDAE) COLLECTED IN NORTH-AMERICA AND SOUTH-AMERICA SO JOURNAL OF MEDICAL ENTOMOLOGY LA English DT Article DE INSECTA; AEDES-ALBOPICTUS; VENEZUELAN EQUINE ENCEPHALOMYELITIS VIRUS; VECTOR POTENTIALS ID VALLEY FEVER VIRUS; VECTOR COMPETENCE; UNITED-STATES; CULEX-PIPIENS; YELLOW-FEVER; DISSEMINATION AB Experimental studies were undertaken to ascertain the vector potential of North American (Houston and Alsace) and South American (Sao Paulo and Santa Teresa) strains of Aedes albopictus (Skuse) for an epizootic (Trinidad donkey) strain of Venezuelan equine encephalomyelitis (VEE) virus. Infection rates were similar in all four strains of Ae. albopictus tested after ingestion of VEE virus from a viremic hamster. Virus disseminated from the midgut to the hemocoel in about 80% of infected mosquitoes, regardless of the dose ingested (10(4.6) to 10(5.7) plaque-forming units per mosquito) or the time of extrinsic incubation (7-35 d). Although all four strains of this mosquito transmitted VEE virus by bite to hamsters, transmission rates were significantly higher for the South American strains (24%, 40 of 170) than for the North American strains (5%, 9 of 165). Although VEE virus has never been isolated from Ae. albopictus, the introduction of this species into the Americas may allow it to serve as an amplification vector in areas where epizootic strains of VEE are found or introduced. RP BEAMAN, JR (reprint author), USA,MED RES INST INFECT DIS,DIV VIROL,FT DETRICK,FREDERICK,MD 21702, USA. NR 19 TC 18 Z9 19 U1 0 U2 0 PU ENTOMOL SOC AMER PI LANHAM PA 9301 ANNAPOLIS RD, LANHAM, MD 20706 SN 0022-2585 J9 J MED ENTOMOL JI J. Med. Entomol. PD JAN PY 1991 VL 28 IS 1 BP 161 EP 164 PG 4 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA EQ856 UT WOS:A1991EQ85600026 PM 2033608 ER PT J AU LATHAM, PS SEPELAK, SB PIFAT, DY SMITH, JF AF LATHAM, PS SEPELAK, SB PIFAT, DY SMITH, JF TI ROLE OF HEPATOCYTES AND KUPFFER CELLS IN AGE-DEPENDENT MURINE HEPATITIS CAUSED BY A PHLEBOVIRUS, PUNTA-TORO SO JOURNAL OF MEDICAL VIROLOGY LA English DT Article DE PHLEBOVIRUS; PUNTA-TORO VIRUS; MOUSE HEPATITIS; VIRAL HEPATITIS; HEPATOCYTES; KUPFFER CELLS ID ADULT-MOUSE HEPATOCYTES; FEVER VIRUS RVFV; RESISTANCE; INVITRO; PATHOGENESIS; MACROPHAGES; INTERFERON AB Punta Toro virus (PTV) infection of C57BL/6 mice results in fulminant hepatic necrosis and death in 3-week-old susceptible mice, but survival with minimal hepatocellular necrosis in 8-week-old resistant mice. Susceptibility in 3-week-old mice is associated with an earlier rise of viral titers in liver and serum than that occurring in 8-week-old resistant mice. There is also an earlier and more rapid accumulation of infectious progeny in serum vs. liver after PTV infection in both age groups, suggesting that the virus may replicate in extrahepatic sites as well as the liver. PTV infection of isolated hepatocytes and Kupffer cells from 3- and 8-week-old mice demonstrates a significant age-related difference in the ability of these cells to support replication of PTV in vitro (P < 0.05). The age-related difference in liver cell-PTV interaction appears to be an inherent difference in the liver cells themselves, since there are no age-related differences in viral adsorption, morphogenesis, cytopathic effect, or interferon action within these cells. Thus, age-related differences in PTV replication or dissemination at extrahepatic sites, and the ability of the virus to replicate in intrahepatic sites, may be additive factors in the expression of age-related susceptibility to PTV in C57BL/6 mice. C1 UNIV MARYLAND HOSP,DEPT MED,BALTIMORE,MD 21201. UNIV MARYLAND HOSP,DEPT PATHOL,BALTIMORE,MD 21201. VET ADM MED CTR,BALTIMORE,MD 21218. USA,MED RES INST INFECT DIS,DIV VIROL,FREDERICK,MD 21701. OI Latham, Patricia/0000-0003-2782-9444 FU NIAID NIH HHS [R01-AI2184-01] NR 21 TC 4 Z9 4 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0146-6615 J9 J MED VIROL JI J. Med. Virol. PD JAN PY 1991 VL 33 IS 1 BP 10 EP 18 DI 10.1002/jmv.1890330104 PG 9 WC Virology SC Virology GA ET450 UT WOS:A1991ET45000003 PM 1901906 ER PT J AU GROEN, J JORDANS, HGM CLEMENT, JPG ROOIJAKKERS, EJM UYTDEHAAG, FGCM DALRYMPLE, J VANDERGROEN, G OSTERHAUS, ADME AF GROEN, J JORDANS, HGM CLEMENT, JPG ROOIJAKKERS, EJM UYTDEHAAG, FGCM DALRYMPLE, J VANDERGROEN, G OSTERHAUS, ADME TI IDENTIFICATION OF HANTAVIRUS SEROTYPES BY TESTING OF POSTINFECTION SERA IN IMMUNOFLUORESCENCE AND ENZYME-LINKED IMMUNOSORBENT ASSAYS SO JOURNAL OF MEDICAL VIROLOGY LA English DT Article DE HANTAVIRUS; HALLNAS VIRUS; SEROLOGICAL SYSTEMS; SEROTYPE ANALYSIS ID RENAL SYNDROME HFRS; HEMORRHAGIC-FEVER; HEMAGGLUTINATION INHIBITION; VIRUS-INFECTIONS; ANTIBODY; SEROEPIDEMIOLOGY; YUGOSLAVIA; DISEASE; SYSTEM AB Serum samples were collected from 27 individuals who had been infected with a member of the genus Hantavirus in the Netherlands or Belgium during the last 15 years. These samples were tested in an immunofluorescence assay (IFA) and two enzyme-linked immunosorbent assay (ELISA) systems, using different virus strains that represented each of the four recently proposed serotypes of this genus. The serum samples from 11 individuals who had been infected through contacts with laboratory rats showed the highest reactivities with Hantaan virus (serotype I) and SR-11 (serotype II) in the IFA and ELISA systems. The samples of 16 individuals who had probably been infected through contacts with wild rodents showed the highest reactivities with Hallnas virus (serotype III) in the IFA. All except two of these also showed the highest reactivity with Hallnas virus in the two different ELISA systems. C1 NATL INST PUBL HLTH & ENVIRONM PROTECT,IMMUNOBIOL LAB,POB 1,3720 BA BILTHOVEN,NETHERLANDS. MED SPECTRUM TWENTE,DEPT INTERNAL MED,ENSCHEDE,NETHERLANDS. USA,MED RES INST INFECT DIS,DEPT VIRAL BIOL,FREDERICK,MD 21701. INST TROP MED,ANTWERP,BELGIUM. NR 24 TC 21 Z9 22 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0146-6615 J9 J MED VIROL JI J. Med. Virol. PD JAN PY 1991 VL 33 IS 1 BP 26 EP 32 DI 10.1002/jmv.1890330106 PG 7 WC Virology SC Virology GA ET450 UT WOS:A1991ET45000005 PM 1901907 ER PT J AU WAGES, JM HAMDALLAH, M CALABRO, MA FOWLER, AK OSTER, CN REDFIELD, RR BURKE, DS AF WAGES, JM HAMDALLAH, M CALABRO, MA FOWLER, AK OSTER, CN REDFIELD, RR BURKE, DS TI CLINICAL-PERFORMANCE OF A POLYMERASE CHAIN-REACTION TESTING ALGORITHM FOR DIAGNOSIS OF HIV-1 INFECTION IN PERIPHERAL-BLOOD MONONUCLEAR-CELLS SO JOURNAL OF MEDICAL VIROLOGY LA English DT Article DE RETROVIRAL DNA; AIDS VIRUS; DNA AMPLIFICATION ID HUMAN IMMUNODEFICIENCY VIRUS; DNA; AMPLIFICATION; INVITRO AB The clinical perfomance of a modified polymerase chain reaction (PCR) testing algorithm was evaluated for confirming the presence of HIV-1 proviral DNA in peripheral blood mononuclear cells. A whole cell lysate, rather than phenol-purified DNA, was used for PCR amplification, under systematically optimized conditions designed and verified within each PCR run to detect as few as 10 copies of proviral DNA. A sequential testing algorithm was designed requiring reactivity in duplicate (with corresponding non-reactivity in negative controls) with at least two sets of primers, before reporting a specimen as HIV-1-positive. In 196 specimens from patients staged according to the Walter Reed staging system, the PCR test sensitivity and the coculture isolation rate (in parentheses) were found to be: 97% (71%), 100% (85%), and 100% (76%) in stage 1, stage 2, and stage 3 specimens, respectively; and 100% (100%) in stage 4,5, and 6 specimens. Results were uniformly negative for PCR and coculture isolation from 21 blind negative specimens and 105 (negative) donor leukopacks. These data indicate that this PCR testing algorithm is more accurate than tissue culture isolation methods, especially with early stage patients, and results in detection of HIV-1 in virtually 100% of seropositive individuals, with no false positives. C1 SRA TECHNOL INC,ROCKVILLE,MD. WALTER REED ARMY MED CTR,INFECT DIS SERV,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DIV RETROVIROL,WASHINGTON,DC 20307. OI /0000-0002-5704-8094 NR 13 TC 23 Z9 23 U1 0 U2 1 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0146-6615 J9 J MED VIROL JI J. Med. Virol. PD JAN PY 1991 VL 33 IS 1 BP 58 EP 63 DI 10.1002/jmv.1890330112 PG 6 WC Virology SC Virology GA ET450 UT WOS:A1991ET45000011 PM 2016602 ER PT J AU EPSTEIN, RM AF EPSTEIN, RM TI THE CREATION AND EVOLUTION OF THE ARMY-CORPS IN THE AMERICAN CIVIL-WAR SO JOURNAL OF MILITARY HISTORY LA English DT Article RP EPSTEIN, RM (reprint author), US ARMY COMMAND & GENERAL STAFF COLL,SCH ADV MIL STUDIES,FT LEAVENWORTH,KS 66027, USA. NR 12 TC 2 Z9 2 U1 0 U2 0 PU VIRGINIA MILITARY INST PI LEXINGTON PA LEXINGTON, VA 24450 SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD JAN PY 1991 VL 55 IS 1 BP 21 EP 46 DI 10.2307/1986127 PG 26 WC History SC History GA ER791 UT WOS:A1991ER79100002 ER PT J AU COOPER, J AF COOPER, J TI OTHER CLAY - A REMEMBRANCE OF THE WORLD-WAR-2 INFANTRY - CAWTHON,CR SO JOURNAL OF MILITARY HISTORY LA English DT Book Review RP COOPER, J (reprint author), US ARMY MIL HIST INST,CARLISLE,PA, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU VIRGINIA MILITARY INST PI LEXINGTON PA LEXINGTON, VA 24450 SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD JAN PY 1991 VL 55 IS 1 BP 127 EP 128 DI 10.2307/1986154 PG 2 WC History SC History GA ER791 UT WOS:A1991ER79100032 ER PT J AU SWINK, W RAUGH, HE AF SWINK, W RAUGH, HE TI RECENT JOURNAL ARTICLES + MILITARY HISTORY SO JOURNAL OF MILITARY HISTORY LA English DT Bibliography C1 US MIL ACAD,DEPT HIST,W POINT,NY 10996. RP SWINK, W (reprint author), US MIL ACAD,LIB,W POINT,NY 10996, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU VIRGINIA MILITARY INST PI LEXINGTON PA LEXINGTON, VA 24450 SN 0899-3718 J9 J MILITARY HIST JI J. Mil. Hist. PD JAN PY 1991 VL 55 IS 1 BP 135 EP 142 PG 8 WC History SC History GA ER791 UT WOS:A1991ER79100035 ER PT J AU MCHALE, KA AF MCHALE, KA TI BILATERAL SPONTANEOUS ARTHRODESIS OF THE HIP AFTER COMBINED SHELF ACETABULAR AUGMENTATION AND FEMORAL VARUS OSTEOTOMIES SO JOURNAL OF PEDIATRIC ORTHOPAEDICS LA English DT Article AB Spontaneous arthrodesis occurred after bilateral, extraarticular shelf augmentation and femoral varus osteotomies in a child with dislocated hips secondary to muscle imbalance from cerebral palsy. The proposed cause if heterotopic bone formation in the hip abductors in the face of insufficient range of motion exercise. RP MCHALE, KA (reprint author), WALTER REED ARMY MED CTR,ORTHOPED SERV,WASHINGTON,DC 20307, USA. NR 0 TC 5 Z9 5 U1 0 U2 0 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0271-6798 J9 J PEDIATR ORTHOPED JI J. Pediatr. Orthop. PD JAN-FEB PY 1991 VL 11 IS 1 BP 108 EP 111 PG 4 WC Orthopedics; Pediatrics SC Orthopedics; Pediatrics GA EP052 UT WOS:A1991EP05200020 PM 1899095 ER PT J AU ROBINSON, NA PACE, JG MATSON, CF MIURA, GA LAWRENCE, WB AF ROBINSON, NA PACE, JG MATSON, CF MIURA, GA LAWRENCE, WB TI TISSUE DISTRIBUTION, EXCRETION AND HEPATIC BIOTRANSFORMATION OF MICROCYSTIN-LR IN MICE SO JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS LA English DT Article ID BLUE-GREEN-ALGA; AERUGINOSA; PEPTIDE; TOXIN; HEPATOTOXIN AB The distribution, excretion and hepatic metabolism of [H-3]microcystin-LR (sublethal i.v.) were measured in mice. Plasma elimination was biexponential with alpha- and beta-phase half-lives of 0.8 and 6.9 min, respectively. At 60 min, liver contained 67 +/- 4% of dose. Through the 6-day study the amount of hepatic radioactivity did not change whereas 23.7 +/- 1.7% of the dose was excreted; 9.2 +/- 1.0% in urine and 14.5 +/- 1.1% in feces. Approximately 60% of the urine and fecal radiolabel 6 and 12 hr postinjection was the parent toxin. Hepatic cytosol, which contained 70 +/- 2% of the hepatic radiolabel (1 hr through 6 days), was prepared for high-performance liquid chromatography analysis by heat denaturation, pronase digestion and C18 Sep Pak extraction. At 1 hr, 35 +/- 2% of the radiolabel was insoluble or C18 Sep Pak-bound; 43 +/- 3% was associated with a peak of retention time (rt) 6.6 min, and 16 +/- 3% with the parent toxin (rt 9.4 mn). After 6 days. 8 +/- % was C18 Sep Pak-bound or insoluble; 5 +/- 0% occurred at rt 6.6 min, 17 +/- 1% with parent and 60 +/- 2% was associated with rt 8.1 min. Two other peaks, rt 4.9 and 5.6 min, appeared transiently. Analysis of hepatic cytosol by desalting chromatography under nondenaturing and denaturing conditions revealed that all of the radiolabel was associated with cytosolic components, and 83 +/- 5% was bound covalently through 1 day. By day 6 the amount of covalently bound isotope decreased to 42 +/- 11%. This is the first study to describe the long-term hepatic retention of microcystin toxin and documents putative detoxication products. C1 USA,MED RES INST INFECT DIS,DIV PATHOPHYSIOL,FT DETRICK,FREDERICK,MD 21701. USA,MED RES INST INFECT DIS,DIV PATHOL,FREDERICK,MD 21701. NR 27 TC 87 Z9 92 U1 1 U2 12 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0022-3565 J9 J PHARMACOL EXP THER JI J. Pharmacol. Exp. Ther. PD JAN PY 1991 VL 256 IS 1 BP 176 EP 182 PG 7 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA ET542 UT WOS:A1991ET54200026 PM 1988656 ER PT J AU WINSLOW, R KIMBALL, A NOBLE, D DENYER, JC VARGHESE, A AF WINSLOW, R KIMBALL, A NOBLE, D DENYER, JC VARGHESE, A TI SIMULATION OF VERY LARGE SINUS NODE AND ATRIAL CELL NETWORKS ON THE CONNECTION MACHINE CM-2 MASSIVELY PARALLEL COMPUTER SO JOURNAL OF PHYSIOLOGY-LONDON LA English DT Meeting Abstract ID RABBIT C1 UNIV MINNESOTA,DEPT PHYSIOL,MINNEAPOLIS,MN 55455. UNIV MINNESOTA,ARMY HIGH PERFORMANCE COMP RES CTR,MINNEAPOLIS,MN 55455. UNIV OXFORD,PHYSIOL LAB,OXFORD,ENGLAND. NR 5 TC 6 Z9 6 U1 0 U2 0 PU CAMBRIDGE UNIV PRESS PI NEW YORK PA 40 WEST 20TH STREET, NEW YORK, NY 10011-4211 SN 0022-3751 J9 J PHYSIOL-LONDON JI J. Physiol.-London PY 1991 VL 438 BP P180 EP P180 PG 1 WC Neurosciences; Physiology SC Neurosciences & Neurology; Physiology GA FY486 UT WOS:A1991FY48600174 ER PT J AU STRICKLAND, RW VUKELJA, SJ WOHLGETHAN, JR CANOSO, JJ AF STRICKLAND, RW VUKELJA, SJ WOHLGETHAN, JR CANOSO, JJ TI HEMORRHAGIC SUBCUTANEOUS BURSITIS SO JOURNAL OF RHEUMATOLOGY LA English DT Article DE BURSITIS; SUBCUTANEOUS BURSITIS; HEMORRHAGIC BURSITIS ID HEMARTHROSIS AB Hemarthrosis is a well recognized complication of a number of conditions. Hemorrhagic subcutaneous bursitis is less understood. We encountered a patient with a myeloproliferative disease who developed hemorrhagic olecranon bursitis. Upon reviewing other patients with subcutaneous bursitis, we found that hemorrhagic bursitis also occurs in the setting of traumatic or idiopathic bursitis, rheumatoid arthritis, gout, and septic bursitis. C1 VET ADM MED CTR JAMAICA PLAIN,RHEUMATOL SECT,BOSTON,MA 02130. NEW ENGLAND MED CTR HOSP,DIV RHEUMATOL,BOSTON,MA 02111. RP STRICKLAND, RW (reprint author), WALTER REED ARMY MED CTR,DEPT MED,SERV RHEUMATOL,WASHINGTON,DC 20307, USA. NR 15 TC 5 Z9 5 U1 0 U2 0 PU J RHEUMATOL PUBL CO PI TORONTO PA 920 YONGE ST, SUITE 115, TORONTO ON M4W 3C7, CANADA SN 0315-162X J9 J RHEUMATOL JI J. Rheumatol. PD JAN PY 1991 VL 18 IS 1 BP 112 EP 114 PG 3 WC Rheumatology SC Rheumatology GA EW175 UT WOS:A1991EW17500026 PM 2023179 ER PT J AU FRIEDL, KE DETTORI, JR HANNAN, CJ PATIENCE, TH PLYMATE, SR AF FRIEDL, KE DETTORI, JR HANNAN, CJ PATIENCE, TH PLYMATE, SR TI COMPARISON OF THE EFFECTS OF HIGH-DOSE TESTOSTERONE AND 19-NORTESTOSTERONE TO A REPLACEMENT DOSE OF TESTOSTERONE ON STRENGTH AND BODY-COMPOSITION IN NORMAL MEN SO JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY LA English DT Article ID FOLLICLE-STIMULATING-HORMONE; ANABOLIC-STEROIDS; LUTEINIZING-HORMONE; ANDROGEN RECEPTOR; SKELETAL-MUSCLE; METHANDIENONE; PERFORMANCE; NANDROLONE; METABOLISM; BINDING AB We examined the extent to which supraphysiological doses of androgen can modify body composition and strength in normally virilized men. In doubly blind tests, 30 healthy young men received testosterone enanthate (TE) or 19-nortestosterone decanoate (ND), at 100 mg/wk or 300 mg/wk for 6 weeks. The TE-100 mg/wk group served as replacement dose comparison, maintaining pretreatment serum testosterone levels, while keeping all subjects blinded to treatment. particularly through reduction in testicular volumes. Isokinetic strength measurements were made for the biceps brachii and quadriceps femoris muscle groups before treatment and 2-3 days after the 6th injection. Small improvements were noted in all groups but the changes were highly variable; a trend to greater and more consistent strength gain occurred in the TE-300 mg/wk group. There was no change in weight for TE- 100 mg/wk but an average gain of 3 kg in each of the other groups. No changes in 4 skinfold thicknesses or in estimated percent body fat were observed. Of 15 circumferences. significant increases were observed only for men receiving TE-300 mg/wk (shoulders) and ND-300 mg/wk (shoulders and chest). The data suggest that high dose androgens increase body mass and may increase strength in normal men but, except for a consistent weight gain with greater than replacement doses, the detectable changes were highly variable and relatively small, especially in comparison to the significant alterations which were observed for other markers of androgen action. C1 MADIGAN ARMY MED CTR,DEPT CLIN INVEST,TACOMA,WA 98431. RP FRIEDL, KE (reprint author), USA,ENVIRONM MED RES INST,DIV EXERCISE PHYSIOL,NATICK,MA 01760, USA. NR 30 TC 43 Z9 43 U1 1 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0960-0760 J9 J STEROID BIOCHEM JI J. Steroid Biochem. Mol. Biol. PY 1991 VL 40 IS 4-6 BP 607 EP 612 DI 10.1016/0960-0760(91)90283-B PG 6 WC Biochemistry & Molecular Biology; Endocrinology & Metabolism SC Biochemistry & Molecular Biology; Endocrinology & Metabolism GA GT379 UT WOS:A1991GT37900017 PM 1958561 ER PT J AU KAPP, JA AF KAPP, JA TI IMPROVED WIDE-RANGE EXPRESSIONS FOR DISPLACEMENTS AND INVERSE DISPLACEMENTS FOR STANDARD FRACTURE-TOUGHNESS SPECIMENS SO JOURNAL OF TESTING AND EVALUATION LA English DT Article DE FRACTURE MECHANICS; FRACTURE TESTING; FRACTURE SPECIMENS; FRACTURE MECHANICS ANALYSIS ID CRACK AB Wide range expressions (interpolating polynomials) for displacements for standard ASTM fracture testing specimens have been developed. The strategy was to fit displacements as a function of crack length for all the specimens using a similar form of nondimensional displacement. Different forms appear in different ASTM standards for the same or similar specimens. The criterion used to establish the degree of polynomial fit and number of significant figures for the coefficients of the polynomial was for the polynomial to agree with the best available numerical displacement solutions to within 1% or better. Once the polynomials for displacement as a function of crack length were developed, inverted forms of the specific interpolating polynomials were obtained to determine relative crack length (a/W) as a function of displacement. Since the inverted polynomial will be used in tandem with the interpolating polynomial, the inverted polynomial was fit to the interpolating polynomial and not the numerical solution for displacement. Three forms of nondimensional displacements were used to invert the interpolating polynomials. The criterion used to establish the degree of polynomial and the number of significant figures of the coefficients of the polynomial was for the predicted relative crack length to agree with the actual relative crack depth to within 0.0005W. A sensitivity analysis was performed to suggest which form of interpolating polynomial should be used for standards. RP KAPP, JA (reprint author), USA,ARMAMENT RES DEV & ENGN CTR,WATERVLIET,NY 12189, USA. NR 11 TC 10 Z9 10 U1 0 U2 0 PU AMER SOC TESTING MATERIALS PI W CONSHOHOCKEN PA 100 BARR HARBOR DR, W CONSHOHOCKEN, PA 19428-2959 SN 0090-3973 J9 J TEST EVAL JI J. Test. Eval. PD JAN PY 1991 VL 19 IS 1 BP 45 EP 54 PG 10 WC Materials Science, Characterization & Testing SC Materials Science GA FF345 UT WOS:A1991FF34500007 ER PT J AU HARGESHEIMER, EE GRAVES, R LANE, LG MAPPES, GW MYRDAL, G SELLERS, C STOKKER, Y STRONG, AB BARTZ, JK GARNER, FC AF HARGESHEIMER, EE GRAVES, R LANE, LG MAPPES, GW MYRDAL, G SELLERS, C STOKKER, Y STRONG, AB BARTZ, JK GARNER, FC TI COMMITTEE ON ENVIRONMENTAL-QUALITY - RECOMMENDATIONS FOR OFFICIAL METHODS SO JOURNAL OF THE ASSOCIATION OF OFFICIAL ANALYTICAL CHEMISTS LA English DT Note C1 US EPA,MONITORING & SUPPORT LAB,CINCINNATI,OH 45268. MISSISSIPPI STATE CHEM LAB,MISSISSIPPI STATE,MS 39762. WISCONSIN DEPT AGR TRADE & CONSUMER PROTECT,BUR LAB SERV,MADISON,WI 53707. ENVIRONM CANADA,NATL WATER RES INST,RES & APPLICAT BRANCH,BURLINGTON L7R 4A6,ONTARIO,CANADA. CHEM WASTE MANAGEMENT INC,RIVERDALE,IL 60627. LOCKHEED ENGN & SCI CO,LAS VEGAS,NV 89119. US EPA,OFF SOLID WASTE,WASHINGTON,DC 20460. USA,CORPS ENGINEERS,WATERWAYS EXPT STN,ANALYT LAB,VICKSBURG,MS 39180. RP HARGESHEIMER, EE (reprint author), GLENMORE WATERWORKS LAB 35,POB 2100,CALGARY T2P 2M5,ALBERTA,CANADA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AOAC INTERNATIONAL PI GAITHERSBURG PA 481 NORTH FREDRICK AVE, STE 500, GAITHERSBURG, MD 20877-2504 SN 0004-5756 J9 J ASSOC OFF ANA CHEM PD JAN-FEB PY 1991 VL 74 IS 1 BP 194 EP 195 PG 2 WC Chemistry, Analytical SC Chemistry GA EV856 UT WOS:A1991EV85600073 ER PT J AU HANKE, DW OVERTON, MA AF HANKE, DW OVERTON, MA TI PHOSPHYLATION KINETIC CONSTANTS AND OXIME-INDUCED REACTIVATION IN ACETYLCHOLINESTERASE FROM FETAL BOVINE SERUM, BOVINE CAUDATE-NUCLEUS, AND ELECTRIC-EEL SO JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH LA English DT Article ID STOPPED-FLOW; INHIBITION; ORGANOPHOSPHATES; SOMAN; PURIFICATION; PROPHYLAXIS; SUBSTRATE; EFFICACY; THERAPY; INVITRO AB Kinetic constants for selected phosphonate and phosphinate inhibitors of fetal bovine serum acetylcholinesterase (FBS AChE; EC 3.1.1.7), bovine caudate nucleus AChE (BCN AChE), and eel AChE have been determined. Oxime reactivation of the phosphylated enzymes has also been evaluated. In general, a rank order with respect to organophosphorus compound (OP) inhibition of the enzymes was observed: soman (pinacolyl methylphosphonofluoridate) was found to be the most potent inhibitor, and 4-nitrophenyl methyl(phenyl)phosphinate (PMP) the least potent. On average the bimolecular rate constant for soman inhibition of eel AChE was nearly twofold greater (9.3 x 10(7) M-1 s-1) than that for FBS AChE (5.5 x 10(7) M-1 s-1) and nearly fourfold greater than that for BCN AChE (2.2 x 10(7) M-1 s-1). In addition, 4-nitrophenyl chloromethyl(phenyl)phosphinate (CPMP) inhibition of eel AChE on average was nearly 10-fold greater than FBS AChE and three orders of magnitude greater than BCN AChE. The oxime HI-6 reactivated soman phosphonylated enzymes to a considerably greater extent than other oximes, and FBS AChE was notably more responsive to HI-6 than to other oximes. The individual mean values of the k(i) for each inhibitor in each class (phosphonate or phosphinate) were different with respect to each AChE, which may be a reflection of differences in enzyme configuration, whereas the general rank order of inhibitor potency within each class, reflected by the k(i), was similar with respect to each AChE, which may be related to similar active centers. In general, oxime potency and rank order varied with each inhibitor and with each AChE, although there was some similarity in oxime rank order between the two mammalian AChEs. Overall, the data support the selection of FBS AChE as the enzyme of choice for in vitro testing of OP inhibitors and reactivators. C1 USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010. NR 39 TC 6 Z9 6 U1 1 U2 1 PU TAYLOR & FRANCIS PI BRISTOL PA 1900 FROST ROAD, SUITE 101, BRISTOL, PA 19007-1598 SN 0098-4108 J9 J TOXICOL ENV HEALTH JI J. Toxicol. Environ. Health PY 1991 VL 34 IS 1 BP 141 EP 156 PG 16 WC Environmental Sciences; Public, Environmental & Occupational Health; Toxicology SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health; Toxicology GA GF658 UT WOS:A1991GF65800011 PM 1890690 ER PT J AU SMITH, WJ SANDERS, KM GALES, YA GROSS, CL AF SMITH, WJ SANDERS, KM GALES, YA GROSS, CL TI FLOW CYTOMETRIC ANALYSIS OF TOXICITY BY VESICATING AGENTS IN HUMAN-CELLS INVITRO SO JOURNAL OF TOXICOLOGY-CUTANEOUS AND OCULAR TOXICOLOGY LA English DT Article ID MUSTARD AB Some alkylating agents are capable of causing severe blisters (vesication) when they contact human skin. The biochemical basis of vesication is undefined. In this study, we have attempted to establish in vitro models for studying vesication. We have utilized human peripheral blood lymphocytes (PBL) and commercially obtained human epidermal keratinocytes (HEK) with flow cytometry to assess cytotoxicity, DNA changes, and biochemical alterations induced by sulfur mustard (HD) and its monofunctional analogue, chloroethyl ethyl sulfide (CEES). Cytotoxic dose-response curves, in the dose range 10(-6)-10(-3) M, have been generated for both alkylating agents using propidium iodide uptake. HD showed a 2-20-fold higher cytotoxic potency than did CEES. HEKs were 10 times more resistant to the cytotoxic effects of both compounds than were human lymphocytes. Cells in the S phase of the cell cycle were most sensitive to the cytotoxic effects of HD. Flow cytometric DNA histogram analysis demonstrated a blockage by both alkylating agents in the late G1/early S phase of the cell cycle. The peak fluorescent channel positions of the diploid DNA at 24 hr exhibited a slight increase in dye uptake that might be associated with alkylation damage or DNA repair. These results showed that human cells in culture provide models for evaluating the biochemical consequences of alkylation and also may be useful in testing prophylactic and therapeutic compounds against vesication. Flow cytometry provided a rapid and sensitive technique to complement the use of in vitro cellular models in toxicologic studies. RP SMITH, WJ (reprint author), USA,MED RES INST CHEM DEF,BIOCHEM PHARMACOL BRANCH,ABERDEEN PROVING GROUND,MD 21010, USA. NR 4 TC 27 Z9 28 U1 0 U2 1 PU MARCEL DEKKER INC PI NEW YORK PA 270 MADISON AVE, NEW YORK, NY 10016 SN 0731-3829 J9 J TOXICOL-CUTAN OCUL JI J. Toxicol.-Cutan. Ocul. Toxicol. PY 1991 VL 10 IS 1-2 BP 33 EP 42 PG 10 WC Ophthalmology; Toxicology SC Ophthalmology; Toxicology GA GF528 UT WOS:A1991GF52800004 ER PT J AU PETRALI, JP OGLESBY, SB JUSTUS, TA AF PETRALI, JP OGLESBY, SB JUSTUS, TA TI MORPHOLOGICAL EFFECTS OF SULFUR MUSTARD ON A HUMAN SKIN EQUIVALENT SO JOURNAL OF TOXICOLOGY-CUTANEOUS AND OCULAR TOXICOLOGY LA English DT Note AB Testskin, a commercially available human skin equivalent, was used as a model system to study the temporal morphologic effects of a single vesicating vapor dose of sulfur mustard (HD). Samples were exposed to 10-mu-l HD vapor for 8 min and harvested at 1, 3, 6, 12, and 24 hr following exposure. Control samples not exposed to HD were harvested at 0 and 24 hr. Light and electron microscopic analysis revealed that the basal cell of the stratum germinativum was selectively affected beginning at 3-6 hr. These early basal cell changes included an apparent widening of intercellular spaces, a disabling of desmosomal attachments, rounding of cells, nuclear condensations and pyknosis, rearrangement of cytoplasmic tonofilaments to a perinuclear position, and perinuclear blebbing. At 12 and 24 hr, the cytopathologic changes progressed to cytoplasmic vacuolation, swollen endoplasmic reticulum, electron opacities, and necrosis, which now involved suprabasal cell layers as well. At the basement membrane zone, cellular debris and cellular fragments accumulated in the area of the lamina lucida, which appeared to widen this space resulting in the formation of a cleft. In die course of this morphologic study it was observed that skin structures normally present in vivo were absent or incomplete in the human skin equivalent specimens. These included hemidesmosomes, a basement membrane, anchoring filaments, and anchoring fibrils. RP PETRALI, JP (reprint author), USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010, USA. NR 6 TC 19 Z9 19 U1 0 U2 0 PU MARCEL DEKKER INC PI NEW YORK PA 270 MADISON AVE, NEW YORK, NY 10016 SN 0731-3829 J9 J TOXICOL-CUTAN OCUL JI J. Toxicol.-Cutan. Ocul. Toxicol. PY 1991 VL 10 IS 4 BP 315 EP 324 PG 10 WC Ophthalmology; Toxicology SC Ophthalmology; Toxicology GA GR619 UT WOS:A1991GR61900007 ER PT J AU WILLIAMS, GM CULLIS, AG BARNETT, SJ WHITEHOUSE, CR GOLDING, TD DINAN, JH AF WILLIAMS, GM CULLIS, AG BARNETT, SJ WHITEHOUSE, CR GOLDING, TD DINAN, JH TI THE STRUCTURE OF CDTE-INSB MULTILAYERS GROWN ON (001) INSB USING MOLECULAR-BEAM EPITAXY SO JOURNAL OF VACUUM SCIENCE & TECHNOLOGY A-VACUUM SURFACES AND FILMS LA English DT Article ID INSB/CDTE HETEROSTRUCTURES AB Molecular beam epitaxy has been used to prepare multilayer structures of CdTe/InSb on (001) InSb at a growth temperature of 300-degrees-C. Transmission electron microscopy and double crystal x-ray diffraction were employed to analyze the multilayer specimens and also a series of single CdTe layers grown on (001) InSb at substrate temperatures ranging from 180 to 300-degrees-C. The detrimental effect on the CdTe layers of increasing the substrate temperature is clearly demonstrated and modification of the Cd:Te flux ratio during growth is shown to reestablish high structural quality material. Both x-ray and transmission electron microscopy studies confirm the high structural quality that can be achieved when multilayers are grown at 300-degrees-C using the modified Cd:Te flux ratio conditions. These analytical techniques also reveal the presence of strain at each CdTe/InSb interface possibly associated with the formation of a thin (less-than-or-equal-to 2 nm) layer of an indium telluride (e.g., In2 Te3). The growth of high structural quality multilayers with individual layer thicknesses less-than-or-equal-to 22.5 nm is seen to break down rapidly as growth proceeds and a possible explanation for this observation is discussed. C1 UNIV CAMBRIDGE,CAVENDISH LAB,CAMBRIDGE CB3 0HE,ENGLAND. USA,CTR NIGHT VIS & ELECTROOPT,FT BELVOIR,VA 22060. RP WILLIAMS, GM (reprint author), ROYAL SIGNALS & RADAR ESTAB,MALVERN WR14 3PS,WORCS,ENGLAND. NR 19 TC 5 Z9 5 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0734-2101 J9 J VAC SCI TECHNOL A JI J. Vac. Sci. Technol. A-Vac. Surf. Films PD JAN-FEB PY 1991 VL 9 IS 1 BP 71 EP 75 DI 10.1116/1.577133 PG 5 WC Materials Science, Coatings & Films; Physics, Applied SC Materials Science; Physics GA ER675 UT WOS:A1991ER67500013 ER PT J AU SCHNEIDER, ML WHITLATCH, EE AF SCHNEIDER, ML WHITLATCH, EE TI USER-SPECIFIC WATER DEMAND ELASTICITIES SO JOURNAL OF WATER RESOURCES PLANNING AND MANAGEMENT-ASCE LA English DT Article ID URBAN RESIDENTIAL DEMAND; MUNICIPAL WATER; UNITED-STATES; PRICE; MODEL AB Water demand elasticity is estimated for six user categories: residential; commercial; industrial; government; school; and total metered. Eight generalized least-squares, linear regression models are derived for each user category. Explanatory variables tested are price; per capita income; resident population per user account; housing composition; and summer precipitation. Pooled cross-sectional and time series annual data from the city of Columbus, Ohio, and incorporated suburbs are used. The recommended regression is a partial adjustment, generalized least-squares model with cross-sectional dummy variables. Price is a significant factor for all user categories except industry. The greatest price effect was for school accounts, followed by commercial, government, total metered, and residential. Governmental and school demands are most responsive to fluctuations in real income, followed by residential and total metered accounts. Commercial demand was unresponsive to real income. Both short-run and long-run elasticities are available from the partial adjustments model, and the time to reach 90% of the long-run response varies from three to eight years. C1 OHIO STATE UNIV,DEPT CIVIL ENGN,COLUMBUS,OH 43210. RP SCHNEIDER, ML (reprint author), USA,CORPS ENGN,WATERWAYS EXPT STN,3909 HALLS FERRY RD,VICKSBURG,MS 39180, USA. NR 36 TC 25 Z9 26 U1 0 U2 8 PU ASCE-AMER SOC CIVIL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-9496 J9 J WATER RES PL-ASCE JI J. Water Resour. Plan. Manage.-ASCE PD JAN-FEB PY 1991 VL 117 IS 1 BP 52 EP 73 DI 10.1061/(ASCE)0733-9496(1991)117:1(52) PG 22 WC Engineering, Civil; Water Resources SC Engineering; Water Resources GA EP747 UT WOS:A1991EP74700005 ER PT J AU HANSON, H KRAUS, NC AF HANSON, H KRAUS, NC TI NUMERICAL-SIMULATION OF SHORELINE CHANGE AT LORAIN, OHIO SO JOURNAL OF WATERWAY PORT COASTAL AND OCEAN ENGINEERING-ASCE LA English DT Article ID MODEL AB Design of detached breakwaters for shore protection is difficult because the response of the shoreline to these structures is governed by at least 14 geometric-, wave-, and sediment-related variables. Numerical models of shoreline change have the potential of incorporating these variables to predict the time evolution of the beach plan shape; however, wave transmission at breakwaters has been a major process absent from such models. In this paper, a pragmatic method of calculating the breaking-wave height and angle under combined transmission, diffraction, refraction, and shoaling is tested to predict shoreline change measured at Lorain, Ohio, the site of a three-segment transmissive breakwater system. The model successfully simulated observed shoreline change at the site that occurred over three time periods ranging from one to five years. Model sensitivity to changes in key parameters and simulations of alternative shore-protection designs to the Lorain project are also described. C1 USA ENGN,COASTAL ENGN RES CTR,WATERWAYS EXPT STN,VICKSBURG,MS 39180. RP HANSON, H (reprint author), UNIV LUND,INST SCI & TECH,DEPT WATER RESOURSE ENGN,BOX 118,S-22100 LUND,SWEDEN. NR 32 TC 13 Z9 18 U1 0 U2 2 PU ASCE-AMER SOC CIVIL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-950X J9 J WATERW PORT C-ASCE JI J. Waterw. Port Coast. Ocean Eng.-ASCE PD JAN-FEB PY 1991 VL 117 IS 1 BP 1 EP 18 DI 10.1061/(ASCE)0733-950X(1991)117:1(1) PG 18 WC Engineering, Civil; Engineering, Ocean; Water Resources SC Engineering; Water Resources GA ET135 UT WOS:A1991ET13500001 ER PT J AU CAMFIELD, FE AF CAMFIELD, FE TI WAVE-FORCES ON WALL SO JOURNAL OF WATERWAY PORT COASTAL AND OCEAN ENGINEERING-ASCE LA English DT Note RP CAMFIELD, FE (reprint author), USA ENGN,COASTAL ENGN RES CTR,WATERWAYS EXPT,VICKSBURG,MS 39180, USA. NR 8 TC 3 Z9 3 U1 0 U2 0 PU ASCE-AMER SOC CIVIL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-950X J9 J WATERW PORT C-ASCE JI J. Waterw. Port Coast. Ocean Eng.-ASCE PD JAN-FEB PY 1991 VL 117 IS 1 BP 76 EP 79 DI 10.1061/(ASCE)0733-950X(1991)117:1(76) PG 4 WC Engineering, Civil; Engineering, Ocean; Water Resources SC Engineering; Water Resources GA ET135 UT WOS:A1991ET13500006 ER PT J AU HANSON, D AF HANSON, D TI SINES REVISITED - DISCUSSION SO JOURNAL OF WATERWAY PORT COASTAL AND OCEAN ENGINEERING-ASCE LA English DT Discussion RP HANSON, D (reprint author), USA CORPS ENGINEERS,UMATILLA,FL 32784, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASCE-AMER SOC CIVIL ENG PI NEW YORK PA 345 E 47TH ST, NEW YORK, NY 10017-2398 SN 0733-950X J9 J WATERW PORT C-ASCE JI J. Waterw. Port Coast. Ocean Eng.-ASCE PD JAN-FEB PY 1991 VL 117 IS 1 BP 97 EP 98 DI 10.1061/(ASCE)0733-950X(1991)117:1(97.2) PG 2 WC Engineering, Civil; Engineering, Ocean; Water Resources SC Engineering; Water Resources GA ET135 UT WOS:A1991ET13500017 ER PT J AU CORCORAN, KD JAAX, GP AF CORCORAN, KD JAAX, GP TI AN ATTEMPT TO PREDICT ANERGY IN TUBERCULOSIS SUSPECT CYNOMOLGUS MONKEYS SO LABORATORY ANIMAL SCIENCE LA English DT Article ID RHESUS-MONKEYS AB Acid-fast microorganisms were identified from the tuberculous lesions of a male cynomolgus monkey (Macaca fascicularis). Twenty-two other cynomolgus monkeys housed in the same room were presumed exposed to tuberculosis (Mycobacterium spp.). In addition to standard intradermal (ID) tuberculin testing, clinicians attempted to evaluate the immune status of these monkeys in order to identify animals exhibiting false negative (anergy) ID tuberculin tests. Twenty-one of the potentially exposed monkeys were immunized with tetanus toxoid (TT). Tetanus antitoxin (TAT) titers were measured before and after immunization. The delayed cutaneous hypersensitivity (DCH) reaction to TT was evaluated using a commercially available human test panel. Some animals did not exhibit a DCH reaction to TT. At necropsy 1 of the 21 animals exhibited tuberculous lesions, and acid-fast microorganisms were identified on direct smears of lymphatic tissue of a second animal. Although reported to be of value in assessing the cellular immune status of rhesus monkeys (Macaca mulatta), the delayed cutaneous hypersensitivity response to tetanus toxoid was not helpful during this outbreak in identifying cynomolgus monkeys infected with M. tuberculosis, or in interpreting suspect ID tuberculin tests. RP CORCORAN, KD (reprint author), USA,MED RES INST CHEM DEF,ABERDEEN PROVING GROUND,MD 21010, USA. NR 17 TC 15 Z9 15 U1 0 U2 0 PU AMER ASSOC LABORATORY ANIMAL SCIENCE PI CORDOVA PA 70 TIMBERCREEK DR, SUITE 5, CORDOVA, TN 38018 SN 0023-6764 J9 LAB ANIM SCI JI Lab. Anim. Sci. PD JAN PY 1991 VL 41 IS 1 BP 57 EP 62 PG 6 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA EY638 UT WOS:A1991EY63800011 PM 1849589 ER PT J AU MCNEIL, JS TORRINGTON, KG MUNDIE, TG BANKS, RA PHILLIPS, YY RIPPLE, GR AF MCNEIL, JS TORRINGTON, KG MUNDIE, TG BANKS, RA PHILLIPS, YY RIPPLE, GR TI PREDICTION OF CARBON-MONOXIDE DIFFUSING-CAPACITY OF THE LUNG IN SPLENECTOMIZED SHEEP SO LABORATORY ANIMAL SCIENCE LA English DT Article ID SINGLE-BREATH; HEMATOCRIT AB The steady state diffusing capacity of the lung for carbon monoxide (D(L)CO) was studied in 18 splenectomized adult ewes. Seven animals were anemic when studied. Weight (Wt) and, to a lesser extent, hemoglobin (Hb) level were the key predictive variables of D(L)CO. Sheep D(L)CO can be expected to range between 15 and 28 ml/min/mmHg in adult ewes which are not anemic. When D(L)CO measurements were repeated up to three times on the same day no significant decreases occurred. Thus, the data demonstrated no CO back-pressure caused by preceding D(L)CO determinations. This paper's importance is in defining a normal predictive range for this sensitive parameter of pulmonary function. RP MCNEIL, JS (reprint author), WALTER REED ARMY MED CTR,DEPT RESP RES,DIV MED,WASHINGTON,DC 20307, USA. NR 12 TC 4 Z9 4 U1 0 U2 0 PU AMER ASSOC LABORATORY ANIMAL SCIENCE PI CORDOVA PA 70 TIMBERCREEK DR, SUITE 5, CORDOVA, TN 38018 SN 0023-6764 J9 LAB ANIM SCI JI Lab. Anim. Sci. PD JAN PY 1991 VL 41 IS 1 BP 63 EP 65 PG 3 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA EY638 UT WOS:A1991EY63800012 PM 1849591 ER PT J AU YU, JHY VASEL, EJ HOYT, RF PHILLIPS, YY DODD, KT AF YU, JHY VASEL, EJ HOYT, RF PHILLIPS, YY DODD, KT TI AUTOLOGOUS PERFUSION OF AN ISOLATED RABBIT GASTROINTESTINAL-TRACT SO LABORATORY ANIMAL SCIENCE LA English DT Article AB Most perfusion techniques rely on mechanical means to provide blood flow to the isolated organ for maintaining its physiological conditions. The approach usually requires a complicated mechanical system with the associated problems of blood type matching and prevention of blood cell damage. This paper describes a gastrointestinal tract perfusion technique that uses the rabbit's own cardiopulmonary system as the autologous blood supply source. The technique allows for the removal of the complete intestinal loop from the abdominal cavity of the rabbit, and maintains its blood circulation through silastic tubing connections of the catherterized portal vein and cranial and caudal mesenteric arteries. An alternative perfusion site that uses the aorta as the arterial blood supply and the vena cava as the venous return also is described. The isolated perfused GI tract may then be placed in a separate test environment for controlled experiments. For an acute animal test, the approach was found to be a convenient alternative to conventional approaches. C1 WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. RP YU, JHY (reprint author), JAYCOR,SAN DIEGO,CA 92138, USA. NR 7 TC 1 Z9 1 U1 0 U2 1 PU AMER ASSOC LABORATORY ANIMAL SCIENCE PI CORDOVA PA 70 TIMBERCREEK DR, SUITE 5, CORDOVA, TN 38018 SN 0023-6764 J9 LAB ANIM SCI JI Lab. Anim. Sci. PD JAN PY 1991 VL 41 IS 1 BP 66 EP 69 PG 4 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA EY638 UT WOS:A1991EY63800013 PM 1849592 ER PT J AU VOGEL, AP JAAX, GP TEZAKREID, TM BASKIN, SI BARTHOLOMEW, JL AF VOGEL, AP JAAX, GP TEZAKREID, TM BASKIN, SI BARTHOLOMEW, JL TI AMBULATORY ELECTROCARDIOGRAPHY (HOLTER MONITORING) IN CAGED MONKEYS SO LABORATORY ANIMALS LA English DT Article DE AMBULATORY MONITORING; ELECTROCARDIOGRAPHY; MACACA SPECIES ID NONHUMAN-PRIMATES; MACACA-FASCICULARIS; TETHERING SYSTEM; KETAMINE AB A swivel-tethering and jacket system was used in conjunction with vinyl patch electrodes and Holter recorders to obtain continuous ECG recordings in 12 rhesus monkeys on a long-term (12 day) study. Animals were custom-fitted with nylon mesh jackets that were connected to a swivel unit by a flexible, stainless steel tether. Lead wires from the chest electrodes passed through the tether to the electrical swivel apparatus located at the top of the cage. Wires from the upper part of the swivel were attached to a reel-to-reel Holter recorder. This technique was used to obtain 24-h continuous ECG recordings, which were later processed using a computer-assisted Holter analysis system. C1 USA,MED RES INST CHEM DEF,DIV VET MED & LAB RESOURCES,ABERDEEN PROVING GROUND,MD 21010. NR 14 TC 4 Z9 4 U1 0 U2 1 PU ROYAL SOC MEDICINE SERVICES LTD PI LONDON PA 1 WIMPOLE STREET, LONDON, ENGLAND W1M 8AE SN 0023-6772 J9 LAB ANIM JI Lab. Anim. PD JAN PY 1991 VL 25 IS 1 BP 16 EP 20 DI 10.1258/002367791780808266 PG 5 WC Veterinary Sciences; Zoology SC Veterinary Sciences; Zoology GA EU119 UT WOS:A1991EU11900004 PM 2010971 ER PT J AU MERRERA, G JACKSON, MS SANDERS, PW BIRMINGHAM, UAB BROOKE, JD REDDY, BV HARBARGEN, JA AF MERRERA, G JACKSON, MS SANDERS, PW BIRMINGHAM, UAB BROOKE, JD REDDY, BV HARBARGEN, JA TI THE ROLE OF ULTRASTRUCTURAL IMMUNOLABELING IN CHARACTERIZING RENAL MANIFESTATIONS OF LIGHT CHAIN (LC) MYELOMA SO LABORATORY INVESTIGATION LA English DT Meeting Abstract C1 UNIV MISSISSIPPI,JACKSON,MS 39216. UNIV ALABAMA,BIRMINGHAM,AL 35233. FITZSIMONS ARMY MED CTR,AURORA,CO 80045. VET ADM MED CTR,DENVER,CO 80220. DWIGHT D EISENHOWER ARMY MED CTR,FT GORDON,GA 30905. NR 0 TC 0 Z9 0 U1 0 U2 0 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0023-6837 J9 LAB INVEST JI Lab. Invest. PD JAN PY 1991 VL 64 IS 1 BP A97 EP A97 PG 1 WC Medicine, Research & Experimental; Pathology SC Research & Experimental Medicine; Pathology GA EV366 UT WOS:A1991EV36600590 ER PT J AU TOWNSEND, AT ADAMS, DK LOPEZ, JB KIRBY, AW AF TOWNSEND, AT ADAMS, DK LOPEZ, JB KIRBY, AW TI EFFECT OF DIISOPROPYLFLUOROPHOSPHATE ON MUSCARINIC AND GAMMA-AMINOBUTYRIC-ACID RECEPTORS IN VISUAL-CORTEX OF CATS SO LIFE SCIENCES LA English DT Article ID CHRONIC CHOLINESTERASE INHIBITION; STRIATE CORTEX; EVOKED-RESPONSES; BINDING; NEURONS; SYSTEM; DOPAMINE; BRAIN; SITES AB Administration of diisopropylfluorophosphate (DFP), an organophosphorus (OP) compound, irreversibly inhibits acetylcholinesterase (AChE) and results in cholinergic hyperactivity. This study investigated muscarinic and gamma-aminobutyric acid (GABA) receptor changes in visual cortex of cats following an acute exposure to DFP. A single acute administration of DFP (4 mg/kg) decreased the number of muscarinic receptors at 2, 10, and 20 hours after treatment. GABA receptors were elevated at 2 and 10 hours but returned to within control levels at 20 hours. No significant alteration in muscarinic or GABA receptor affinity was noted. In all cases cortical AChE activity was inhibited 60-90%. These findings show a down regulation of muscarinic receptors after DFP associated with low AChE activity. GABA receptors also are altered, and may be part of a compensatory mechanism to counteract excess cholinergic stimulation. RP TOWNSEND, AT (reprint author), USA,AEROMED RES LAB,SENSORY NEUROSCI RES BRANCH,FT RUCKER,AL 36362, USA. NR 27 TC 4 Z9 4 U1 1 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0024-3205 J9 LIFE SCI JI Life Sci. PY 1991 VL 49 IS 15 BP 1053 EP 1060 DI 10.1016/0024-3205(91)90592-Y PG 8 WC Medicine, Research & Experimental; Pharmacology & Pharmacy SC Research & Experimental Medicine; Pharmacology & Pharmacy GA GD061 UT WOS:A1991GD06100001 PM 1654488 ER PT J AU CHIANG, PK BUTLER, DL BROWN, ND AF CHIANG, PK BUTLER, DL BROWN, ND TI NICOTINIC ACTION OF ANATOXIN-A ON GUINEA-PIG ILEUM ANTAGONIZED BY THYMOPENTIN SO LIFE SCIENCES LA English DT Letter ID AGONIST; ANTIMUSCARINICS; ACETYLCHOLINE; RECEPTOR AB (+)-Anatoxin-a (ANTX) stimulated guinea pig ileum contraction with a potency similar to that of acetylcholine (ACh); the stimulation was blocked by tubocurarine, hexamethonium, or atropine. Although the contraction stimulated by ANTX was blocked by atropine, no specific inhibition of the binding of [H-3]N-methylscopolamine to ileum membranes was observed in the presence of ANTX. Furthermore, ANTX failed to stimulate the secretion of alpha-amylase from pancreatic acinar cells, a process that is activated by cholinergic agonists at the muscarinic receptors. When the ileum itself was stimulated by ACh, the contraction was not blocked by either hexamethonium or tubocurarine. Preincubation of the ileum with hemicholinium caused a 50% reduction in the ability of ANTX to stimulate contraction. Based upon these data, it was inferred that ANTX binds to postganglionic synaptic nicotinic receptors in the ileum, thus releasing endogenous ACh, which in turn causes ileum contraction by interacting with the postsynaptic muscarinic receptors. It was also observed that thymopentin (TP-5), a pentapeptide corresponding to positions 32-36 of thymopoietin, blocked the stimulation of ileum contraction by ANTX. RP CHIANG, PK (reprint author), WALTER REED ARMY MED CTR,APPL BIOCHEM BRANCH,WASHINGTON,DC 20307, USA. NR 16 TC 3 Z9 3 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0024-3205 J9 LIFE SCI JI Life Sci. PY 1991 VL 49 IS 6 BP PL13 EP PL19 DI 10.1016/0024-3205(91)90591-X PG 7 WC Medicine, Research & Experimental; Pharmacology & Pharmacy SC Research & Experimental Medicine; Pharmacology & Pharmacy GA FW471 UT WOS:A1991FW47100010 PM 1865746 ER PT J AU ANDERSON, DR HARRIS, LW LIESKE, CN LENNOX, WJ AF ANDERSON, DR HARRIS, LW LIESKE, CN LENNOX, WJ TI EVALUATION OF PHOSPHINATES AS POTENTIAL PRETREATMENTS FOR NERVE AGENTS SO LIFE SCIENCES LA English DT Article ID EEL ACETYLCHOLINESTERASE; PROTECTION; ANIMALS; ATROPINE; SOMAN; OXIME; PYRIDOSTIGMINE; REACTIVATION AB To assess the utility of phosphinates as pretreatments against nerve agents, experiments were conducted to determine whether oximes can reactivate phosphinate-inhibited guinea pig acetylcholinesterase (AChE) and whether the toxicity of phosphinates is reduced by treatment with atropine and/or oxime. Three phosphinates, 4-nitrophenyl methyl(phenyl) phosphinate (MPP), 4-nitrophenyl chloromethyl(phenyl) phosphinate (CMPP), and 4-nitrophenyl 2-methoxyphenyl(methyl) phosphinate (MPMP), were used in these experiments. In the first group of experiments, 2-PAM or HI-6 was administered, im, 2 min after peak inhibition of whole blood AChE activity by the phosphinates. Both oximes significantly reactivated MPP- or CMPP-inhibited AChE; however, HI-6 was the better reactivator in both cases. Oximes were ineffective against MPMP. Efficacy studies revealed that neither HI-6 nor 2-PAM potentiated the toxic effects of MPP or CMPP and that atropine/oxime therapy provided greater protection (up to 100 LD50s) against either phosphinate than any single therapy. The reactivation and efficacy data, especially for CMPP, support the concept that oxime sensitive phosphinates may be useful as pretreatments against nerve agent intoxication. RP ANDERSON, DR (reprint author), USA,MED RES INST CHEM DEFENSE,SGRD-UV-PA,ABERDEEN PROVING GROUND,MD 21010, USA. NR 21 TC 0 Z9 0 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0024-3205 J9 LIFE SCI JI Life Sci. PY 1991 VL 48 IS 25 BP 2463 EP 2468 DI 10.1016/0024-3205(91)90382-L PG 6 WC Medicine, Research & Experimental; Pharmacology & Pharmacy SC Research & Experimental Medicine; Pharmacology & Pharmacy GA FM975 UT WOS:A1991FM97500014 PM 2046471 ER PT J AU WITKIN, JM TORTELLA, FC AF WITKIN, JM TORTELLA, FC TI MODULATORS OF N-METHYL-D-ASPARTATE PROTECT AGAINST DIAZEPAM-RESISTANT OR PHENOBARBITAL-RESISTANT COCAINE CONVULSIONS SO LIFE SCIENCES LA English DT Note ID PHENCYCLIDINE-LIKE DRUGS; ANTICONVULSANT PROPERTIES; NMDA RECEPTORS; ACID; RATS; DEXTROMETHORPHAN; COMPLICATIONS; ANTAGONISTS; ABUSE AB The anticonvulsants diazepam (1-10 mg/kg) and phenobarbital (30-100 mg/kg) protected against lethality without altering clonic convulsions induced by 75 mg/kg cocaine (CD100) in male Swiss Webster mice. In contrast, the non-competitive N-methyl-D-aspartate (NMDA) antagonists, MK-801 (dizocilpine) and phencyclidine, produced dose-dependent protection against cocaine convulsions. The competitive NMDA antagonists, CPP and NPC 12626, were also anti- convulsant, without producing the behavioral disturbances associated with non-competitive antagonists. Diazepam and phenobarbital protected against convulsions induced by 60 mg/kg cocaine (90% convulsions alone). Compounds that act at the strychnine-insensitive glycine receptor of the NMDA receptor complex, ACPC and 7-chlorokynurinic acid, also protected against convulsions induced by 60 mg/kg cocaine. In contrast, the non-opioid antitussive anticonvulsants (dextromethorphan, caramiphen, and carbetapentane) were not active against either dose of cocaine. The efficacy of compounds as antagonists of the convulsant effects of cocaine and NMDA appear related. These results suggest a potential role for the NMDA receptor complex in the convulsant actions of cocaine and new molecular targets for drug discovery in treating cocaine toxicity. C1 WALTER REED ARMY MED CTR,NEUROPHARMACOL BRANCH,WASHINGTON,DC 20307. RP WITKIN, JM (reprint author), NIDA,ADDICT RES CTR,PSYCHOBIOL LAB,DRUG DEV GRP,POB 5180,BALTIMORE,MD 21224, USA. NR 26 TC 44 Z9 44 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0024-3205 J9 LIFE SCI JI Life Sci. PY 1991 VL 48 IS 11 BP PL51 EP PL56 DI 10.1016/0024-3205(91)90516-E PG 6 WC Medicine, Research & Experimental; Pharmacology & Pharmacy SC Research & Experimental Medicine; Pharmacology & Pharmacy GA EY110 UT WOS:A1991EY11000013 PM 1847729 ER PT J AU JAMES, WF BARKO, JW AF JAMES, WF BARKO, JW TI ESTIMATION OF PHOSPHORUS EXCHANGE BETWEEN LITTORAL AND PELAGIC ZONES DURING NIGHTTIME CONVECTIVE CIRCULATION SO LIMNOLOGY AND OCEANOGRAPHY LA English DT Note ID NORTH-TEMPERATE RESERVOIR; ANOXIC HYPOLIMNIA; LAKES; MACROPHYTES; WATER; WISCONSIN; SEDIMENTS; MIGRATION; SHALLOW AB A fluorescent dye was used in Eau Galle Reservoir, Wisconsin, to examine nighttime convective circulation patterns and exchanges of P between the littoral and pelagic zones during 25-26 July and 12-13 September 1988. Cooler littoral bottom water moved into the pelagic zone at night as an interflow at 2.5 m in July and at 4.0 m in September. Warmer pelagic water moved into the littoral zone as a surface flow during both periods. The littoral zone exhibited high total P concentrations above the sediment in July, but much lower concentrations in September. Estimated net areal total P flux to the pelagic zone was 1.8 mg m-2 d-1 in July but only 0.2 mg m-2 d-1 in September. Net areal total P flux in July accounted for approximately 22% of the summer average, lakewide internal total P load to the reservoir. C1 USA CORPS ENGINEERS,WATERWAYS EXPT STN,ENVIRONM LAB,VICKSBURG,MS 39180. NR 23 TC 49 Z9 50 U1 1 U2 5 PU AMER SOC LIMNOLOGY OCEANOGRAPH PI LAWRENCE PA 810 EAST 10TH ST, LAWRENCE, KS 66044-8897 SN 0024-3590 J9 LIMNOL OCEANOGR JI Limnol. Oceanogr. PD JAN PY 1991 VL 36 IS 1 BP 179 EP 187 PG 9 WC Limnology; Oceanography SC Marine & Freshwater Biology; Oceanography GA FL676 UT WOS:A1991FL67600016 ER PT J AU AXENROD, T LIANG, B BASHIRHASHEMI, A DAVE, PR REDDY, DS AF AXENROD, T LIANG, B BASHIRHASHEMI, A DAVE, PR REDDY, DS TI COMPLETE H-1 AND C-13 ASSIGNMENT OF SOME CUBANE DERIVATIVES BY 2D NMR-SPECTROSCOPY SO MAGNETIC RESONANCE IN CHEMISTRY LA English DT Article DE CUBANES; ONE-BOND; C-13-H COUPLING CONSTANTS ID COHERENCE TRANSFER SPECTROSCOPY; SHIFT CORRELATION; HETERONUCLEAR C1 ARDEC,GEO CTR INC,LAKE HOPATCONG,NJ 07849. USA,CTR RES DEV & ENGN CTR,PICATINNY ARSENAL,NJ 07806. RP AXENROD, T (reprint author), CUNY CITY COLL,DEPT CHEM,NEW YORK,NY 10031, USA. NR 10 TC 16 Z9 17 U1 0 U2 0 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0749-1581 J9 MAGN RESON CHEM JI Magn. Reson. Chem. PD JAN PY 1991 VL 29 IS 1 BP 88 EP 91 DI 10.1002/mrc.1260290117 PG 4 WC Chemistry, Multidisciplinary; Chemistry, Physical; Spectroscopy SC Chemistry; Spectroscopy GA EV063 UT WOS:A1991EV06300016 ER PT J AU INGBER, L FUJIO, H WEHNER, MF AF INGBER, L FUJIO, H WEHNER, MF TI MATHEMATICAL COMPARISON OF COMBAT COMPUTER-MODELS TO EXERCISE DATA SO MATHEMATICAL AND COMPUTER MODELLING LA English DT Article ID FOKKER-PLANCK EQUATIONS; PATH-INTEGRAL SOLUTIONS; TERM-MEMORY CAPACITY; TIME-SERIES MODEL; NEOCORTICAL INTERACTIONS; STATISTICAL-MECHANICS; NUMERICAL EVALUATION; RIEMANNIAN CONTRIBUTIONS; SYSTEMS; EQUILIBRIUM AB The powerful techniques of modern nonlinear statistical mechanics are used to compare battalion scale combat computer models (including simulations and wargames) to exercise data. This is necessary if large-scale combat computer models are to be extrapolated with confidence to develop battle-management, C3 and procurement decision-aids, and to improve training. This modeling approach to battalion level missions is amenable to reasonable algebraic and/or heuristic approximations to drive higher-echelon computer models. Each data set is fit to several candidate short-time probability distributions, using methods of "very fast simulated re-annealing" with a Lagrangian (time-dependent algebraic cost-function) derived from nonlinear stochastic rate equations. These candidate mathematical models are further tested by using path-integral numerical techniques we have developed to calculate long-time probability distribution spanning the combat scenario. We have demonstrated proofs of principle, that battalion level combat exercises can be well represented by the computer simulation JANUS(T), and that modern methods of nonlinear nonequilibrium statistical mechanics can well model these systems. Since only relatively simple drifts and diffusions were required, in larger systems, e.g., at brigade and division levels, it might be possible to "absorb" other important variables (C3, human factors, logistics, etc.) into more nonlinear mathematical forms. Otherwise, this battalion level model should be supplemented with a "tree" of branches corresponding to estimated values of these variables. C1 USN,POSTGRAD SCH,TRADOC ANAL COMMAND,MONTEREY,CA 93940. USN,POSTGRAD SCH,DEPT PHYS,MONTEREY,CA 93940. UNIV CALIF LAWRENCE LIVERMORE NATL LAB,LIVERMORE,CA 94550. RI Ingber, Lester/G-6087-2010 OI Ingber, Lester/0000-0003-1502-3910 NR 67 TC 26 Z9 26 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0895-7177 J9 MATH COMPUT MODEL JI Math. Comput. Model. PY 1991 VL 15 IS 1 BP 65 EP 90 DI 10.1016/0895-7177(91)90017-2 PG 26 WC Computer Science, Interdisciplinary Applications; Computer Science, Software Engineering; Mathematics, Applied SC Computer Science; Mathematics GA FE675 UT WOS:A1991FE67500007 ER PT J AU JONES, B FREEMAN, AI SHUSTER, JJ JACQUILLAT, C WEIL, M POCHEDLY, C SINKS, L CHEVALIER, L MAURER, HM KOCH, K FALKSON, G PATTERSON, R SELIGMAN, B SARTORIUS, J KUNG, F HAURANI, F STUART, M BURGERT, EO RUYMANN, F SAWITSKY, A FORMAN, E PLUESS, H TRUMAN, J HAKAMI, N GLIDEWELL, O GLICKSMAN, AS HOLLAND, JF AF JONES, B FREEMAN, AI SHUSTER, JJ JACQUILLAT, C WEIL, M POCHEDLY, C SINKS, L CHEVALIER, L MAURER, HM KOCH, K FALKSON, G PATTERSON, R SELIGMAN, B SARTORIUS, J KUNG, F HAURANI, F STUART, M BURGERT, EO RUYMANN, F SAWITSKY, A FORMAN, E PLUESS, H TRUMAN, J HAKAMI, N GLIDEWELL, O GLICKSMAN, AS HOLLAND, JF TI LOWER INCIDENCE OF MENINGEAL LEUKEMIA WHEN PREDNISONE IS REPLACED BY DEXAMETHASONE IN THE TREATMENT OF ACUTE LYMPHOCYTIC-LEUKEMIA SO MEDICAL AND PEDIATRIC ONCOLOGY LA English DT Article DE CANCER AND LEUKEMIA GROUP-B; CNS LEUKEMIA; STEROID THERAPY ID CENTRAL-NERVOUS-SYSTEM; ACUTE LYMPHOBLASTIC LEUKEMIA; CRANIAL IRRADIATION; CHILDHOOD LEUKEMIA; INTENSIVE CHEMOTHERAPY; CHILDREN; METHOTREXATE; PROPHYLAXIS; PREVENTION; PROTOCOL AB In 1971, Cancer and Leukemia Group B (CALGB) mounted a study of acute lymphocytic leukemia (ALL) that compared the effects of the two steroid hormones dexamethasome and prednisone. Six-hundred-forty-six children and adolescents with ALL were randomized to receive either prednisone or dexamethasone as part of their remission induction therapy. The 493 evaluable patients who achieved complete remission received the same steroid as pulses throughout remission. Specific central nervous system (CNS) therapy was randomized to either six injections of intrathecal methotrexate (IT MTX) alone or to six injections of IT MTX with cranial radiation (2,400 cGy). Both cranial radiation and dexamethasone offered increased protection against CNS relapse as the first site of failure over IT MTX alone. There were 30 CNS relapses among 238 patients (12.6%) receiving cranial radiation plus IT MTX, whereas there were 70 CNS relapses among 225 (P < 0.001) (22.5%) in those who received IT MTX alone. Similarly, there were 33 CNS relapses among 231 (14.3%) children treated with dexamethasone, whereas there were 67 CNS relapses among 262 (25.6%) treated with prednisone (P = 0.017). Both steroids appeared equal in protecting the bone marrow. Recent national studies have shown significant improvements in preventing CNS relapse over the results in the present report. However, this finding warrants further investigation and, with further documentation, could lead to the substitution of prednisone by dexamethasone to aid further in preventing CNS relapse. This may be particularly important in patients at higher risk for CNS relapse. C1 NEW YORK STATE DEPT HLTH,ROSWELL PK MEM INST,BUFFALO,NY 14263. UNIV FLORIDA,DEPT STAT,GAINESVILLE,FL 32611. HOP ST LOUIS,INST RECH LEUCEMIES,F-75010 PARIS,FRANCE. MONTREAL CHILDRENS HOSP,MONTREAL H3H 1P3,QUEBEC,CANADA. VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,RICHMOND,VA 23298. UNIV MIAMI,MED CTR,MIAMI,FL 33152. UNIV PRETORIA,PRETORIA,SOUTH AFRICA. WAKE FOREST UNIV,BOWMAN GRAY SCH MED,WINSTON SALEM,NC 27103. UNIV BASEL,KINDERSPITAL,CH-4051 BASEL,SWITZERLAND. UNIV CALIF SAN DIEGO,LA JOLLA,CA 92093. THOMAS JEFFERSON UNIV,JEFFERSON MED COLL,PHILADELPHIA,PA 19107. SUNY UPSTATE MED CTR,SYRACUSE,NY 13210. MAYO CLIN & MAYO FDN,ROCHESTER,MN 55905. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. LONG ISL JEWISH MED CTR,NEW HYDE PK,NY 11042. BROWN UNIV,PROVIDENCE,RI 02912. RHODE ISL HOSP,PROVIDENCE,RI 02902. KINDERSPITAL,CH-8032 ZURICH,SWITZERLAND. MASSACHUSETTS GEN HOSP,BOSTON,MA 02114. UNIV MISSOURI,COLUMBIA,MO 65201. CUNY MT SINAI SCH MED,NEW YORK,NY 10029. MT SINAI HOSP,NEW YORK,NY. SUNY,JEWISH HOSP BROOKLYN,BROOKLYN,NY. NR 33 TC 102 Z9 105 U1 0 U2 3 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0098-1532 J9 MED PEDIATR ONCOL JI Med. Pediatr. Oncol. PY 1991 VL 19 IS 4 BP 269 EP 275 DI 10.1002/mpo.2950190411 PG 7 WC Oncology; Pediatrics SC Oncology; Pediatrics GA FT990 UT WOS:A1991FT99000010 PM 2056971 ER PT J AU DAWSON, NA COSTANZA, ME KORZUN, AH CLAMON, GH POLLAK, M VOGELZANG, NJ CAREY, RW NORTON, L AF DAWSON, NA COSTANZA, ME KORZUN, AH CLAMON, GH POLLAK, M VOGELZANG, NJ CAREY, RW NORTON, L TI TRIMETREXATE IN UNTREATED AND PREVIOUSLY TREATED PATIENTS WITH METASTATIC BREAST-CANCER - A CANCER AND LEUKEMIA GROUP-B STUDY SO MEDICAL AND PEDIATRIC ONCOLOGY LA English DT Article DE CARCINOMA; BREAST; TRIMETREXATE ID PHASE-I; CLINICAL-PHARMACOLOGY; SCHEDULE AB Twenty-two patients with previously untreated metastatic breast cancer and nineteen patients with refractory metastatic breast cancer were treated with trimetrexate (TMTX). Patients received TMTX 8 mg/m2/day if previously treated or 12 mg/m2/day if previously untreated, both given by intravenous bolus days 1-5, every 21 days. None of the patients previously treated for metastatic disease responded to TMTX. There was one partial responder among the 22 patients with previously untreated metastatic disease. The primary toxicity was hematologic and occurred more frequently in patients with a pleural effusion, low serum protein or albumin, or poor performance status. There were three toxic deaths. The study for previously untreated patients required cyclophosphamide, doxorubicin, and 5-fluorouracil (CAF) after 4 cycles of TMTX. This study design for previously untreated patients allows the Cancer and Leukemia Group B (CALGB) to prospectively evaluate the activity of new agents in "chemotherapy-sensitive" metastatic breast cancer. C1 UNIV MASSACHUSETTS,SCH MED,WORCESTER,MA 01605. HARVARD UNIV,SCH PUBL HLTH,BOSTON,MA 02115. UNIV IOWA,IOWA CITY,IA 52242. UNIV CHICAGO,CHICAGO,IL 60637. MASSACHUSETTS GEN HOSP,BOSTON,MA 02114. MEM SLOAN KETTERING CANC CTR,NEW YORK,NY 10021. MCGILL CANC CTR,MONTREAL,QUEBEC,CANADA. RP DAWSON, NA (reprint author), WALTER REED ARMY MED CTR,HEMATOL ONCOL SERV,WASHINGTON,DC 20307, USA. RI Pollak, Michael/G-9094-2011 OI Pollak, Michael/0000-0003-3047-0604 FU NCI NIH HHS [CA-47642, CA-31809, CA-41287] NR 16 TC 12 Z9 12 U1 0 U2 0 PU WILEY-LISS PI NEW YORK PA DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 SN 0098-1532 J9 MED PEDIATR ONCOL JI Med. Pediatr. Oncol. PY 1991 VL 19 IS 4 BP 283 EP 288 DI 10.1002/mpo.2950190413 PG 6 WC Oncology; Pediatrics SC Oncology; Pediatrics GA FT990 UT WOS:A1991FT99000012 PM 1829134 ER PT J AU WIRTZ, RA CHAROENVIT, Y BURKOT, TR ESSER, KM BEAUDOIN, RL COLLINS, WE ANDRE, RG AF WIRTZ, RA CHAROENVIT, Y BURKOT, TR ESSER, KM BEAUDOIN, RL COLLINS, WE ANDRE, RG TI EVALUATION OF MONOCLONAL-ANTIBODIES AGAINST PLASMODIUM-VIVAX SPOROZOITES FOR ELISA DEVELOPMENT SO MEDICAL AND VETERINARY ENTOMOLOGY LA English DT Article DE MALARIA VECTORS; PLASMODIUM-VIVAX; CIRCUMSPOROZOITE PROTEIN; SPOROZOITE IDENTIFICATION; ELISA AB Nine monoclonal antibodies (MAbs) developed against Plasmodium vivax (Grassi & Feletti) salivary gland sporozoites were evaluated for use in an enzyme-linked immunosorbent assay (ELISA), using sporozoites developed in Anopheles dirus Peyton & Harrison An.gambiae Giles and An.maculatus Theobald. Four of the antibodies were unsuitable due to the low sensitivity of the resulting assays or the requirement for high concentrations of capture antibody. An additional two MAbs were rejected because they resulted in assays with high background absorbance, attributed to self-binding. Of the three remaining MAbs, the use of Navy vivax sporozoite (NVS) 3 resulted in an ELISA with the highest sensitivity and the lowest concentration requirement for capture antibody. Assay sensitivity varied with sporozoite strain indicating possible quantitative epitope heterogeneity. None of the MAbs cross-reacted with the heterologous sporozoites tested by immunofluorescence antibody assay (IFA). The IFA activity was not an indicator of ELISA sensitivity. The use of MAb NVS 3 in a standardized ELISA method resulted in an assay 10 times more sensitive than reported previously for P.vivax sporozoites, with a detection limit of fewer than 100 sporozoites per mosquito. RP WIRTZ, RA (reprint author), WALTER REED ARMY MED CTR,DEPT ENTOMOL,WASHINGTON,DC 20307, USA. RI Burkot, Thomas/C-6838-2013 NR 0 TC 30 Z9 30 U1 0 U2 4 PU BLACKWELL SCIENCE LTD PI OXFORD PA OSNEY MEAD, OXFORD, OXON, ENGLAND OX2 0EL SN 0269-283X J9 MED VET ENTOMOL JI Med. Vet. Entomol. PD JAN PY 1991 VL 5 IS 1 BP 17 EP 22 DI 10.1111/j.1365-2915.1991.tb00515.x PG 6 WC Entomology; Veterinary Sciences SC Entomology; Veterinary Sciences GA EZ658 UT WOS:A1991EZ65800003 PM 1768896 ER PT J AU MILLS, JN CALDERON, GE ELLIS, BA MCKEE, KT KSIAZEK, TG ORO, JGB PETERS, CJ CHILDS, JE MAIZTEGUI, JI AF MILLS, JN CALDERON, GE ELLIS, BA MCKEE, KT KSIAZEK, TG ORO, JGB PETERS, CJ CHILDS, JE MAIZTEGUI, JI TI NEW OBSERVATIONS OF JUNIN VIRUS-INFECTIONS IN RODENTS WITHIN AND BEYOND THE ENDEMIC AREA OF ARGENTINE HEMORRHAGIC-FEVER SO MEDICINA-BUENOS AIRES LA Spanish DT Article ID PROGRESSIVE EXTENSION AB In conjunction with field trials for a vaccine against Argentine Hemorrhagic Fever (AHF), small mammals were trapped during a 28-month period (1 November 1987 to 13 March 1990) in 3 epidemiologically defined areas of the central Argentine pampas: northern and central Buenos Aires provinces were included in the AHF "historic" area, where the disease was common 15-20 years ago, but case rates are currently low; southern Santa Fe province is the current high-incidence area for AHF; the nonendemic area was represented by two localities 60-90 km beyond the northernmost extension of human disease. Animals were live-trapped for 3 days per month in permanent "mark-recapture" grids in each of the 3 areas. Samples of blood, sera, and oral swabs were taken from these animals before they were marked and released at the site of capture. In addition, "removal" traplines provided animals from 16 localities in these 3 areas which were sacrificed to obtain samples of organs in addition to the aforementioned samples. Samples were tested for the presence of Junin virus (JV) antigen by enzyme immunoassay (ELISA). In this assay, a pool of 13 mouse anti-JV glycoprotein and nucleocapsid monoclonal antibodies adsorbed to the surface of microtiter plates was used to capture JV antigen in sample suspensions. A polyclonal rabbit anti-JV antiserum was added as a detector antibody, and an anti-rabbit antibody conjugated to horseradish peroxidase applied with substrate to complete the sandwich. Optical density values read at 410 nm were adjusted by substracting corresponding wells coated with normal ascitic fluid in place of the monoclonals; this adjusted value was taken as a measure of the specific amount of antigen bound in the assay. A total of 4870 mammals of 15 species were tested; 97% of captures and all positives were of 7 rodent species. Of these, the numbers of animals tested by species were: 1794 Calomys laucha, 1085 C. musculinus, 852 Akodon azarae, 360 Oligoryzomys flavescens, 345 Bolomys obscurus, 286 Mus musculus, y 4 Oxymycterus rufus (Table 1). Fifty-five of the 60 antigen-positive animals came from the high-incidence area, for an overall prevalence of infection of 1.7% of rodents captured (Table 1). Four positive animals were captured in the historic area (prevalence = 0.4%), and only 1 was captured in the nonendemic area (prevalence = 0.2%). The prevalence of infection was highly variable among localities (0.2% to 3.8%, discounting the 5 localities without positives; Table 1) and the distribution of positives was patchy. Two farms in the same locality yielded infection rates of 9% and 0%, respectively. Forty-three of the 60 positives were C. musculinus (4.0% infection in that species; Table 1). The prevalence in B. obscurus was relatively high (1.2%), while those for C. laucha, A. azarae, and M. musculus were low (0.30. 5%). One of only 4 O. rufus captured was positive. Presence of virus in all of these species except M. musculus was confirmed by isolation in Vero cells. Although no antigen-positive O. flavescens were detected by ELISA, isolation attempts on a subsample of 13 of these animals yielded 2 positives4. The methods used in our study are different from those used in previous studies of JV infection in rodent populations in the endemic area of AHF. We were able to complete more than 2 years of uninterrupted sampling at 6 permanent study sites in and near the AHF endemic area. The enzyme immunoassay used in our study, however, has been shown to be highly specific, but less sensitive than Vero-cell isolation4. Despite these differences in methodology, our data are in agreement with those of other investigators indicating that C. musculinus is the principal reservoir of JV5,8. Our data also indicate that the relative prevalence of JV infection in the rodent population in the epidemic and historic areas is in accordance with the prevalence of human cases in these areas2. We have also provided additional evidence that JV is circulating in areas where AHF has never been recognized and that the disease may continue its epxansion toward the northwest. Moreover, we have demonstrated the presence of Junin virus or JV antigen in three genera (Bolomys, Oligoryzomys and Oxymycterus) which have not previously been implicated as carriers of JV. The relatively high rate of infection of B. obscurus, combined with that species' capacity to shed virus for at least 30 days p.i.5, makes it a potentially important natural reservoir of JV. C1 INST NACL ESTUDIOS VIROSIS HEMORRAG,CC 195,RA-2700 PERGAMINO,BUENOS AIRES,ARGENTINA. JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,DEPT IMMUNOL & INFECT DIS,BALTIMORE,MD 21218. USA,MED RES INST INFECT DIS,FREDERICK,MD 21701. RI Childs, James/B-4002-2012 NR 9 TC 5 Z9 5 U1 0 U2 2 PU MEDICINA (BUENOS AIRES) PI BUENOS AIRES PA DONATO ALVAREZ 3150, 1427 BUENOS AIRES, ARGENTINA SN 0025-7680 J9 MEDICINA-BUENOS AIRE JI Med.-Buenos Aires PY 1991 VL 51 IS 6 BP 519 EP 523 PG 5 WC Medicine, General & Internal SC General & Internal Medicine GA JN310 UT WOS:A1991JN31000003 PM 7476104 ER PT J AU MCCARTHY, MF BRAUN, TG AF MCCARTHY, MF BRAUN, TG TI INFECTION CONTROL OF FIELD DENTAL UNITS SO MILITARY MEDICINE LA English DT Article AB The need for infection control procedures exists for dental care provided outside of dental treatment facilities. In a wartime scenario or during military training exercises, traditional dental clinic settings may not be available and the dental officer will be required to treat patients using equipment provided by the Army's Table of Organization and Equipment. This article reviews the dental literature and makes recommendations to aid the dental officer in developing an infection-control protocol for field dental equipment. RP MCCARTHY, MF (reprint author), USA,DENTAC,10TH SPECIAL FORCES GRP AIRBORNE,FT DEVENS,MA 01433, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD JAN PY 1991 VL 156 IS 1 BP 5 EP 8 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA EQ769 UT WOS:A1991EQ76900002 PM 1900121 ER PT J AU XENAKIS, SN MARCUM, JM MAURY, JL DUFFY, JC AF XENAKIS, SN MARCUM, JM MAURY, JL DUFFY, JC TI CONSULTATION IN THE AFTERMATH OF AN AIR TRAGEDY SO MILITARY MEDICINE LA English DT Article AB In the early morning hours of December 12, 1985, a chartered jet airliner carrying 248 soldiers crashed shortly after takeoff, killing all aboard. The day after, the authors were designated as a consultation team to the mental health staff at Fort Campbell who were providing services in the aftermath of the crash. This report describes and analyzes the experiences of this consultation on diaster management. Our consulting experience has been one of the most profound and demanding events of our professional lives. Salient lessons of the consultation include: (a) the need to clarify leadership roles among the local mental health care team; (b) the need to help the local team establish clear roles among team members; (c) the value of enabling the local team to mourn the loss of their fellow soldiers and community members; and (d) the value of establishing a clear plan of mental health services for both short-term and long-term management. RP XENAKIS, SN (reprint author), USA,COLL WAR,CARLISLE BARRACKS,603 WILSON ST,CARLISLE,PA 17013, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU ASSN MILITARY SURG US PI BETHESDA PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 SN 0026-4075 J9 MIL MED JI Milit. Med. PD JAN PY 1991 VL 156 IS 1 BP 23 EP 26 PG 4 WC Medicine, General & Internal SC General & Internal Medicine GA EQ769 UT WOS:A1991EQ76900009 PM 1900112 ER PT B AU LONG, JB OLESHANSKY, MA DECOSTA, BR AF LONG, JB OLESHANSKY, MA DECOSTA, BR BE KAMENKA, JM DOMINO, EF TI SELECTIVE SIGMA-LIGANDS PROTECT AGAINST SPINAL-CORD INJURY IN RATS - INVIVO AND INVITRO EVIDENCE SO MULTIPLE SIGMA AND PCP RECEPTOR LIGANDS : MECHANISMS FOR NEUROMODULATION AND NEUROPROTECTION ? LA English DT Proceedings Paper CT 3RD JOINT FRENCH / UNITED-STATES SEMINAR ON MULTIPLE SIGMA AND PCP ( PHENCYCLIDINE ) RECIPTOR LIGANDS : MECHANISMS FOR NEUROMODULATION AND NEUROPROTECTION CY SEP 15-19, 1991 CL MONTPELLIER, FRANCE SP CNRS, NATL SCI FDN, CONSEIL REG LANGUEDOC ROUSSILLON, CONSEIL GEN HERAULT, DIRECT RECH ETUDE & TECH, ECOLE NATL SUPER CHIM MONTPELLIER, UNIV MICHIGAN, AMER CYANAMID, ANAQUEST, BERLEX LABS RP LONG, JB (reprint author), WALTER REED ARMY MED CTR,DEPT MED NEUROSCI,DIV NEUROPSYCHIAT,BLDG 40,WASHINGTON,DC 20307, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NPP BOOKS PI ANN ARBOR PA ANN ARBOR BN 0-916182-09-6 PY 1991 BP 673 EP 686 PG 14 WC Biochemistry & Molecular Biology; Neurosciences; Pharmacology & Pharmacy SC Biochemistry & Molecular Biology; Neurosciences & Neurology; Pharmacology & Pharmacy GA BV79L UT WOS:A1991BV79L00057 ER PT J AU BLAISDELL, GL AF BLAISDELL, GL TI PERFORMANCE OF AN OMNIDIRECTIONAL WHEEL ON SNOW AND ICE SO NAVAL ENGINEERS JOURNAL LA English DT Article AB A brief study was performed to investigate the suitability of service vehicles equipped with a unique omnidirectional wheel operating aboard aircraft carriers in northern latitudes, where ice and snow on flight decks is not uncommon. This study addressed the comparative performance of the omnidirectional wheel, a bias-ply highway tire as used on current Navy MD-3 aircraft tow vehicles, a typical nonpneumatic forklift truck tire, and an automotive radial-ply all-season tire. The tires were tested for driving traction levels on prepared ice, hard-packed snow, and fresh shallow snow. In general, the omnidirectional wheel showed performance superior to the forklift truck tire and the bias-ply highway tire. The radial all-season tire, however, outperformed the omnidirectional wheel in traction on slippery surfaces. The omnidirectional wheel was found to be well-behaved during traction testing and shows promise for operation on winter surfaces. Recommendations are provided that might further improve omnidirectional wheel performance on snow and ice. RP BLAISDELL, GL (reprint author), USA,COLD REG RES & ENGN LAB,HANOVER,NH 03755, USA. NR 0 TC 3 Z9 3 U1 1 U2 1 PU AMER SOC NAVAL ENG INC PI ALEXANDRIA PA 1452 DUKE STREET, ALEXANDRIA, VA 22314-3458 SN 0028-1425 J9 NAV ENG J JI Nav. Eng. J. PD JAN PY 1991 VL 103 IS 1 BP 34 EP 41 PG 8 WC Engineering, Marine; Engineering, Civil; Oceanography SC Engineering; Oceanography GA ET703 UT WOS:A1991ET70300003 ER PT J AU JOHNSON, JL AF JOHNSON, JL TI GLOBALLY STABLE SATURABLE LEARNING LAWS SO NEURAL NETWORKS LA English DT Article DE GLOBAL STABILITY; NEURAL NETWORKS; OPTICAL MEMORY; ADAPTATION; SATURABLE LEARNING; LYAPUNOV FUNCTION; TEMPORAL COMPETITION; CODE STABILITY; STORAGE CAPACITY AB This article discusses minimal saturable learning laws that incorporate deassociative as well as associative behavior. The requirement of global stability results in new terms for the nodal activity equation. These terms provide temporal competition of a node with its own past history and imply spontaneous code protection and better memory storage capacity for a slab. One variant of these saturable learning laws is identified as the fringe contrast in an emulsion-based optical holographic interconnection implementation. RP JOHNSON, JL (reprint author), USA,MISSILE RES & DEV COMMAND,AMSMI RD RE OP,REDSTONE ARSENAL,AL 35809, USA. NR 6 TC 3 Z9 3 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0893-6080 J9 NEURAL NETWORKS JI Neural Netw. PY 1991 VL 4 IS 1 BP 47 EP 51 DI 10.1016/0893-6080(91)90030-9 PG 5 WC Computer Science, Artificial Intelligence SC Computer Science GA EW407 UT WOS:A1991EW40700005 ER PT J AU RAYBURN, DB JANUSZKIEWICZ, AJ RIPPLE, GR TRUWIT, J SUMMEY, HF YOUNG, TR KLIMASAUSKAS, CC LEE, JM SNAPPER, JR AF RAYBURN, DB JANUSZKIEWICZ, AJ RIPPLE, GR TRUWIT, J SUMMEY, HF YOUNG, TR KLIMASAUSKAS, CC LEE, JM SNAPPER, JR TI IDENTIFICATION OF MEDIATOR SPECIFIC CARDIOVASCULAR WAVE-FORMS USING A BACK PROPAGATION NEURAL NETWORK SO NEURAL NETWORKS LA English DT Article DE PULMONARY; BACK PROPAGATION; SHEEP; CARDIOVASCULAR; PHYSIOLOGICAL; PLATELET ACTIVATING FACTOR; PROSTAGLANDIN ID LUNG INJURY AB A diverse milieu of inhaled substances induce the release of endogenous mediators. These mediators are responsible for the symptoms manifested by a wide spectrum of allergic and toxic scenarios. Platelet activating factor (PAF) and prostaglandin H-2 analog (PGH) are two such mediators. A sheep was exposed to varied doses of PAF and PGH. Five parameters were monitored to characterize the cardiovascular response. A back propagation network was used to analyze the response data. The network was trained using three different groups of 21 of the 28 total data sets. In each case, seven data sets were withheld from training and used to assess the performance of the networks. In each case, the back propagation network (BPN) qualitatively and quantitatively (error < 10%) identified the causal mediator. This study demonstrates the utility of using analysis afforded by neural networks to decipher complex physiologic waveforms into mediator-specific events. C1 VANDERBILT UNIV,MED CTR,SCH MED,NASHVILLE,TN 37232. UNIV VIRGINIA,HLTH SCI CTR,CHARLOTTESVILLE,VA 22903. RP RAYBURN, DB (reprint author), WALTER REED ARMY MED CTR,DIV MED,DEPT RESP RES,WASHINGTON,DC 20307, USA. NR 10 TC 3 Z9 3 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0893-6080 J9 NEURAL NETWORKS JI Neural Netw. PY 1991 VL 4 IS 4 BP 525 EP 530 DI 10.1016/0893-6080(91)90049-B PG 6 WC Computer Science, Artificial Intelligence SC Computer Science GA GA146 UT WOS:A1991GA14600011 ER PT J AU HUBLER, GK WADDELL, CN DONOVAN, EP ZAVADA, JM AF HUBLER, GK WADDELL, CN DONOVAN, EP ZAVADA, JM TI BELOW-BANDGAP REFRACTIVE-INDEX OF ALAS GAAS MULTIPLE QUANTUM-WELLS SO OPTICAL AND QUANTUM ELECTRONICS LA English DT Article ID OPTICAL-PROPERTIES; SUPERLATTICES AB Precision reflection measurements were performed on GaAs/AlAs superlattices of the same composition but different layer spacings. Nonlinear-least-squares fits to the data were performed to a single layer. Measurements were extracted for the superlattice thickness, thickness of a disturbed interface layer between the superlattice and substrate, the uniformity in composition and/or spacing and the composition. It was demonstrated that these nondestructive measurements in the infrared region (3000 to 12 000 cm-1) in conjunction with a simple single layer model are capable of accurately yielding the above quantities with high precision. C1 USA,RES OFF,RALEIGH,NC 27709. RP HUBLER, GK (reprint author), USN,RES LAB,WASHINGTON,DC 20375, USA. NR 15 TC 2 Z9 2 U1 0 U2 1 PU CHAPMAN HALL LTD PI LONDON PA 2-6 BOUNDARY ROW, LONDON, ENGLAND SE1 8HN SN 0306-8919 J9 OPT QUANT ELECTRON JI Opt. Quantum Electron. PY 1991 VL 23 IS 7 BP S883 EP S893 DI 10.1007/BF00624977 PG 11 WC Engineering, Electrical & Electronic; Optics SC Engineering; Optics GA GD239 UT WOS:A1991GD23900010 ER PT J AU MURPHY, TP AF MURPHY, TP TI MRI OF THE FACIAL-NERVE DURING PARALYSIS SO OTOLARYNGOLOGY-HEAD AND NECK SURGERY LA English DT Article; Proceedings Paper CT 1990 ANNUAL MEETING OF THE AMERICAN NEUROTOLOGY SOC CY MAY 27-29, 1990 CL PALM BEACH, FL SP AMER NEUROTOL SOC ID RESONANCE AB Gadolinium-enhanced MRI was used to evaluate 10 patients with Bell's palsy and one patient with facial paralysis secondary to Lyme disease. Nine of the eleven patients showed increased signal intensity of their facial nerve with gadolinium-enhanced MRI. In all nine patients, the facial nerve was involved at the labyrinthine, geniculate ganglion and proximal tympanic portions of the facial nerve, while two of the nine patients also had involvement of the mastoid segment of the facial nerve. Patients whose facial nerve enhancement was limited to the labyrinthine, geniculate ganglion and proximal tympanic facial nerve ultimately had complete return of facial function. Patients whose facial nerve enhanced in the mastoid segment experienced incomplete return of facial function. Gadolinium is effective in localizing the site of inflammation during facial paralysis. Those patients with enhancement localized to the labyrinthine, geniculate ganglion and proximal tympanic segments were more likely to regain complete facial function. In contrast, patients who had enhancement of the mastoid segment of the facial nerve had poorer prognoses for complete return of facial function. C1 BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234. NR 5 TC 47 Z9 47 U1 1 U2 1 PU MOSBY-YEAR BOOK INC PI ST LOUIS PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 SN 0194-5998 J9 OTOLARYNG HEAD NECK JI Otolaryngol. Head Neck Surg. PD JAN PY 1991 VL 104 IS 1 BP 47 EP 51 PG 5 WC Otorhinolaryngology; Surgery SC Otorhinolaryngology; Surgery GA EU429 UT WOS:A1991EU42900010 PM 1900629 ER PT J AU RUFF, ME SCHOTIK, DA BASS, JW VINCENT, JM AF RUFF, ME SCHOTIK, DA BASS, JW VINCENT, JM TI ANTIMICROBIAL DRUG SUSPENSIONS - A BLIND COMPARISON OF TASTE OF FOURTEEN COMMON PEDIATRIC DRUGS SO PEDIATRIC INFECTIOUS DISEASE JOURNAL LA English DT Article DE DRUG SUSPENSIONS; ANTIMICROBIALS; TASTE COMPARISON AB Children of preschool age most often receive medications in liquid form, and smell and taste are major determinats in achieving compliance. We compared smell, taste and other characteristics of 14 commonly prescribed antimicrobial suspensions in a blind test in 30 adult volunteers to determine whether there was a difference in their acceptability. A significant difference was observed with cephalosporins ranking highest and penicillins ranking lowest. Our findings support anecdotal observations and claims often made by parents that cephalosporin antimicrobial suspensions taste good and are readily accepted by children and that penicillin suspensions have an unpleasant taste and aftertaste and are poorly accepted. Other drugs had intermediate scores. Of the two erythromycin suspensions evaluated, Ilosone(R) tested superior to Erythromycin ES(R). C1 TRIPLER ARMY MED CTR,DEPT PEDIAT,HONOLULU,HI 96859. TRIPLER ARMY MED CTR,DEPT PHARM,HONOLULU,HI 96859. NR 8 TC 53 Z9 53 U1 1 U2 2 PU WILLIAMS & WILKINS PI BALTIMORE PA 351 WEST CAMDEN ST, BALTIMORE, MD 21201-2436 SN 0891-3668 J9 PEDIATR INFECT DIS J JI Pediatr. Infect. Dis. J. PD JAN PY 1991 VL 10 IS 1 BP 30 EP 33 DI 10.1097/00006454-199101000-00007 PG 4 WC Immunology; Infectious Diseases; Pediatrics SC Immunology; Infectious Diseases; Pediatrics GA ER580 UT WOS:A1991ER58000006 PM 2003053 ER PT J AU STOBIE, PE HANSEN, CT HAILEY, JR LEVINE, RL AF STOBIE, PE HANSEN, CT HAILEY, JR LEVINE, RL TI A DIFFERENCE IN MORTALITY BETWEEN 2 STRAINS OF JAUNDICED RATS SO PEDIATRICS LA English DT Article DE BILIRUBIN; KERNICTERUS; GUNN RATS; JAUNDICE ID BILIRUBIN; BRAIN AB Homozygous Gunn rats lack bilirubin glucuronyltransferase, become jaundiced, and other develop kernicterus, thus providing a model for neonatal hyper-bilirubinemia. Two new, inbred rat strains that carry the Gunn mutation are described. These were developed by breeding the mutant Gunn gene (j) into the RHA/N and ACI/N strains, producing the new lines, which were designated RHA/N-j and ACI/N-j. Liver assay confirmed the absence of transferase activity in jaundiced rats from both of the new strains, but marked differences in mortality between the strains were observed. The mortality of jaundiced RHA/N-j rats through 8 weeks was the same as that of their nonjaundiced littermates (20%). In contrast, mortality of jaundiced ACI/N-j rats was distinctly greater than that of their nonjaundiced littermates (81%) vs 34%, P < .001). Signs of kernicterus such as ataxia were much more frequent in jaundiced ACI/N-j rats than in jaundiced RHA/N-j rats (73% vs 11%, P < .001). Both strains had comparable albumin concentrations through 8 weeks of age. Serum bilirubin concentrations were also comparable, except for a small but significant difference at 20 days of age (ACI/N-j - 294-mu-mol/L, RHA/N-j = 248-mu-mol/L P < .01). Similarly, the bilirubin-to-albumin ratios were comparable except for a significantly higher ratio at 20 days of age in the ACI-N-j rats (ACI/N-j = .07, RHA/N-j = 0.51, < .01). Thus, the RHA/N-j strain is unusual in that the jaundiced animals healthy. Conversely, the ACI/N-j animals demonstrate a high incidence of kernicterus with mortality. This dramatic strain difference implies that factors in addition to deficiency of bilirubin glucuronyltranserase are modulating the susceptibility to bilirubin toxicity. C1 NHLBI,BIOCHEM LAB,BLDG 3,ROOM 106,BETHESDA,MD 20892. NIH,VET RESOURCES BRANCH,BETHESDA,MD 20892. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,DEPT PEDIAT,BETHESDA,MD 20814. RI Levine, Rodney/D-9885-2011 NR 22 TC 9 Z9 9 U1 0 U2 0 PU AMER ACAD PEDIATRICS PI ELK GROVE VILLAGE PA 141 NORTH-WEST POINT BLVD, ELK GROVE VILLAGE, IL 60007-1098 SN 0031-4005 J9 PEDIATRICS JI Pediatrics PD JAN PY 1991 VL 87 IS 1 BP 88 EP 93 PG 6 WC Pediatrics SC Pediatrics GA EQ978 UT WOS:A1991EQ97800015 PM 1898623 ER PT J AU ROTHMAN, RB LONG, JB BYKOV, V XU, H JACOBSON, AE RICE, KC HOLADAY, JW AF ROTHMAN, RB LONG, JB BYKOV, V XU, H JACOBSON, AE RICE, KC HOLADAY, JW TI UP-REGULATION OF THE OPIOID RECEPTOR COMPLEX BY THE CHRONIC ADMINISTRATION OF MORPHINE - A BIOCHEMICAL MARKER RELATED TO THE DEVELOPMENT OF TOLERANCE AND DEPENDENCE SO PEPTIDES LA English DT Article DE MORPHINE TOLERANCE; NALTREXONE; BETA-FUNALTREXAMINE; RECEPTOR UP-REGULATION ID RAT-BRAIN MEMBRANES; BETA-ENDORPHIN ANALGESIA; BINDING-SITES; PHYSICAL-DEPENDENCE; OPIATE RECEPTOR; PHARMACOLOGICAL CHARACTERIZATION; ANTIOPIATE TYR-MIF-1; DOWN-REGULATION; DELTA-RECEPTOR; UP-REGULATION AB Studies conducted after the development of the rapid filtration assay for opiate receptors, and before the recognition of multiple opioid receptors, failed to detect changes in opioid receptors induced by chronic morphine. Recent experiments conducted in our laboratories were designed to examine the hypothesis that only one of several opioid receptor types might be altered by chronic morphine. Using binding surface analysis and irreversible ligands to increase the "resolving power" of the ligand binding assay, the results indicated that chronic morphine increased both the B(max) and K(d) of the opioid receptor complex, labeled with either [H-3][D-Ala2,D-Leu5]enkephalin, [H-3][D-Ala2-MePhe4,Gly-ol5]enkephalin or [H-3]6-desoxy-6-beta-fluoronaltrexone. In the present study rats were pretreated with drugs known to attenuate the development of tolerance and dependence [the irreversible mu-receptor antagonist, beta-funaltrexamine (beta-FNA), and the inhibitor of tryptophan hydroxylase, para-chlorophenylalanine], prior to subcutaneous implantation of morphine pellets. The results demonstrated that 1) unlike chronic naltrexone, beta-FNA failed to upregulate opioid receptors and 2) both beta-funaltrexamine and PCPA pretreatment attenuated the chronic morphine-induced increase in the B(max), but not the K(d), of the opioid receptor complex. These results provide evidence that naltrexone-induced upregulation of the opioid receptor complex might occur indirectly as a consequence of interactions at beta-funaltrexamine-insensitive opioid receptors and that morphine-induced upregulation (increased B(max)) of the opioid receptor complex is a relevant in vitro marker related to the development of tolerance and dependence. These data collectively support the hypothesis that endogenous antiopiate peptides play an important role in the development of tolerance and dependence to morphine. C1 WALTER REED ARMY MED CTR,DIV MED NEUROSCI,NEUROPHARMACOL BRANCH,WASHINGTON,DC 20307. NIDDK,MED CHEM LAB,BETHESDA,MD 20892. MEDICIS CORP,WASHINGTON,DC 20006. RP ROTHMAN, RB (reprint author), NIMH,CLIN SCI LAB,RECEPTOR STUDIES UNIT,BLDG 10-3D41,BETHESDA,MD 20892, USA. NR 83 TC 58 Z9 58 U1 0 U2 4 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0196-9781 J9 PEPTIDES JI Peptides PD JAN-FEB PY 1991 VL 12 IS 1 BP 151 EP 160 DI 10.1016/0196-9781(91)90182-O PG 10 WC Biochemistry & Molecular Biology; Endocrinology & Metabolism; Pharmacology & Pharmacy SC Biochemistry & Molecular Biology; Endocrinology & Metabolism; Pharmacology & Pharmacy GA EY791 UT WOS:A1991EY79100026 PM 1646998 ER PT J AU GOUGE, SF CHARNEY, DI AF GOUGE, SF CHARNEY, DI TI DOES INTRAPERITONEAL VANCOMYCIN CAUSE CHEMICAL PERITONITIS SO PERITONEAL DIALYSIS INTERNATIONAL LA English DT Letter RP GOUGE, SF (reprint author), BROOKE ARMY MED CTR,DEPT MED,NEPHROL SERV,FT SAM HOUSTON,TX 78234, USA. NR 5 TC 1 Z9 1 U1 0 U2 0 PU MULTIMED INC PI TORONTO PA 1120 FINCH AVE WEST SUITE 601, TORONTO ON M3J 3H7, CANADA SN 0896-8608 J9 PERITON DIALYSIS INT JI Perit. Dial. Int. PY 1991 VL 11 IS 1 BP 91 EP 91 PG 1 WC Urology & Nephrology SC Urology & Nephrology GA EV770 UT WOS:A1991EV77000022 PM 2049438 ER PT J AU SCOVILL, JP KLAYMAN, DL FLIPPENANDERSON, JL GILARDI, R AF SCOVILL, JP KLAYMAN, DL FLIPPENANDERSON, JL GILARDI, R TI 1,3,4-THIADIAZOLES FROM THIOSEMICARBAZIDES SO PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS LA English DT Article DE 4,4-DIALKYL-3-THIOSEMICARBAZIDES; 4,4-DIALKYL-3-THIOSEMICARBAZONES; 1,1-DIALKYL-6-[1-(ARYLETHYLIDENE) AMINO]-2,5-DITHIOBIUREAS; (5-DIALKYLAMINO-1,3,4-THIADIAZOL-2-YL) HYDRAZONES; ACID CATALYZED CYCLIZATION C1 USN,RES LAB,STRUCT MATTER LAB,WASHINGTON,DC 20375. RP SCOVILL, JP (reprint author), WALTER REED ARMY MED CTR,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307, USA. NR 11 TC 1 Z9 1 U1 0 U2 0 PU GORDON BREACH SCI PUBL LTD PI READING PA C/O STBS LTD PO BOX 90, READING, BERKS, ENGLAND RG1 8JL SN 0308-664X J9 PHOSPHORUS SULFUR JI Phosphorus Sulfur Silicon Relat. Elem. PY 1991 VL 63 IS 3-4 BP 273 EP 281 DI 10.1080/10426509108036830 PG 9 WC Chemistry, Inorganic & Nuclear; Chemistry, Organic SC Chemistry GA GZ079 UT WOS:A1991GZ07900008 ER PT J AU SCOVILL, JP AF SCOVILL, JP TI 1,1-DISUBSTITUTED-6-[1-(ARYLETHYLIDENE)AMINO]-2,5-DITHIOBIUREAS SO PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS LA English DT Article DE 6-AMINO-2,5-DITHIOBIUREAS; ANTIMALARIAL AGENTS; THIOCARBONYL ACTIVATED TRANSAMINATION REACTION; PLASMODIUM BERGHEI C1 WALTER REED ARMY MED CTR, DIV EXPTL THERAPEUT, WASHINGTON, DC 20307 USA. NR 5 TC 2 Z9 2 U1 0 U2 1 PU GORDON BREACH SCI PUBL LTD PI READING PA C/O STBS LTD PO BOX 90, READING, BERKS, ENGLAND RG1 8JL SN 0308-664X J9 PHOSPHORUS SULFUR JI Phosphorus Sulfur Silicon Relat. Elem. PY 1991 VL 61 IS 1-2 BP 77 EP 82 DI 10.1080/10426509108027340 PG 6 WC Chemistry, Inorganic & Nuclear; Chemistry, Organic SC Chemistry GA FT784 UT WOS:A1991FT78400011 ER PT J AU SCOVILL, JP AF SCOVILL, JP TI A FACILE SYNTHESIS OF THIOSEMICARBAZIDES AND THIOSEMICARBAZONES BY THE TRANSAMINATION OF 4-METHYL-4-PHENYL-3-THIOSEMICARBAZIDE SO PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS LA English DT Article DE THIOSEMICARBAZONES; THIOSEMICARBAZIDES; 4-METHYL-4-PHENYL-THIOSEMICARBAZIDE; ACTIVATED TRANSAMINATION REACTIONS ID ANTI-MALARIAL AGENTS; 2-ACETYLPYRIDINE THIOSEMICARBAZONES; COMPLEXES; ANTIMALARIAL C1 USA,MIL ACAD,DEPT CHEM,W POINT,NY 10996. NR 13 TC 134 Z9 134 U1 0 U2 5 PU GORDON BREACH SCI PUBL LTD PI READING PA C/O STBS LTD PO BOX 90, READING, BERKS, ENGLAND RG1 8JL SN 0308-664X J9 PHOSPHORUS SULFUR JI Phosphorus Sulfur Silicon Relat. Elem. PY 1991 VL 60 IS 1-2 BP 15 EP 19 DI 10.1080/10426509108233920 PG 5 WC Chemistry, Inorganic & Nuclear; Chemistry, Organic SC Chemistry GA FL734 UT WOS:A1991FL73400002 ER PT J AU MACTURK, KS EBY, RK ADAMS, WW AF MACTURK, KS EBY, RK ADAMS, WW TI CHARACTERIZATION OF COMPRESSIVE PROPERTIES OF HIGH-PERFORMANCE POLYMER FIBERS WITH A NEW MICROCOMPRESSION APPARATUS SO POLYMER LA English DT Article; Proceedings Paper CT SPECIALITY POLYMERS 90 CY AUG 08-10, 1990 CL JOHNS HOPKINS UNIV, BALTIMORE, MD HO JOHNS HOPKINS UNIV DE FIBER; COMPRESSIBILITY; ELASTICITY ID CARBON-FIBERS AB A microcompression apparatus to measure the compressive stress-strain curve of individual fibres has been developed. Illustrative results were obtained for a series of mesophase-pitch-based carbon fibres. A series of optical micrographs of a P100 fibre were taken as it failed in compression. The ultimate compressive strength (UCS) for any given type of fibre tended to cluster around two average values. The reason for this clustering is uncertain, but the two values may correspond to more and to less 'perfect' fibres. P55 exhibited a higher average UCS of 600 MPa and a lower average of UCS of 300 MPa. P75 had a higher average UCS of 600 MPa and a lower average UCS of 300 MPa. P100 gave a higher average UCS of 400 MPa and a lower average UCS of 150 MPa. The compressive modulus for P75 was 470 GPa. The fibres exhibited non-linear elasticity, with the compressive modulus decreasing as the compressive strain increased. C1 JOHNS HOPKINS UNIV,BALTIMORE,MD 21218. UNIV AKRON,INST POLYMER SCI,AKRON,OH 44325. USAF,CTR RES & DEV,WRIGHT PATTERSON AFB,OH 45433. RP MACTURK, KS (reprint author), UNIV AKRON,DEPT POLYMER SCI,AKRON,OH 44325, USA. RI Adams, Wade/A-7305-2010 NR 18 TC 27 Z9 27 U1 0 U2 5 PU ELSEVIER SCI LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB SN 0032-3861 J9 POLYMER JI Polymer PY 1991 VL 32 IS 10 BP 1782 EP 1787 DI 10.1016/0032-3861(91)90363-N PG 6 WC Polymer Science SC Polymer Science GA FW642 UT WOS:A1991FW64200010 ER PT J AU WARNAS, AA AF WARNAS, AA TI MECHANICAL CREEP AND THE COMPENSATION EFFECT - HDPE SO POLYMER COMMUNICATIONS LA English DT Note DE TENSILE CREEP; HDPE; ACTIVATION ENERGY; COMPENSATION RULE AB The compensation distribution is interpreted in terms of experimental creep data of high density polyethylene (HDPE) and is found to be directly attributable to the distribution in activation energy, obeying the compensation rule. The activation energy is related to the strain. A confirmation of McCrum's findings of large compensation times for polypropylene through mechanical relaxation, using the corrected Bucci thermal sampling experiment, is derived through mechanical tensile creep tests with HDPE. RP WARNAS, AA (reprint author), USA,MAT TECHNOL LAB,WATERTOWN,MA 02172, USA. NR 7 TC 1 Z9 1 U1 0 U2 1 PU BUTTERWORTH-HEINEMANN LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB SN 0263-6476 J9 POLYM COMMUN PY 1991 VL 32 IS 3 BP 83 EP 85 PG 3 WC Polymer Science SC Polymer Science GA EW889 UT WOS:A1991EW88900007 ER PT J AU MAMMONE, RJ BINDER, M AF MAMMONE, RJ BINDER, M TI INFLUENCE OF SUPPORTING AQUEOUS-ELECTROLYTE ON DIELECTRIC-PROPERTIES OF ELECTROCHEMICALLY FORMED POLY-N-METHYLPYRROLE SO POLYMER COMMUNICATIONS LA English DT Article DE DIELECTRIC PROPERTIES; POLY-N-METHYLPYRROLE; ELECTROCHEMICAL SYNTHESIS ID POLYPYRROLE FILMS; POLYMERIZATION; PYRROLE; AMMONIA AB Dielectric properties of poly-N-methylpyrrole (PNMP) electrochemically synthesized from various aqueous electrolytes have been obtained. PNMP prepared from aqueous supporting electrolyte containing sodium sulphate, sulphuric acid, sodium dihydrogen phosphate or phosphoric acid were highly insulating (< 10(-9) S cm-1) while PNMP prepared in aqueous sodium 4-hydroxybenzenesulphonate electrolyte were about 10(5) times more conducting. Elemental analysis indicates that very few sulphate or dihydrogen phosphate anions from the supporting electrolyte actually enter the PNMP lattice. The low dopant level accounts for the poor polymer conductivity. RP MAMMONE, RJ (reprint author), USA,ELECTR TECHNOL & DEVICES LAB,DIV POWER SOURCES,FT MONMOUTH,NJ 07703, USA. NR 12 TC 5 Z9 5 U1 0 U2 0 PU BUTTERWORTH-HEINEMANN LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB SN 0263-6476 J9 POLYM COMMUN PY 1991 VL 32 IS 5 BP 140 EP 142 PG 3 WC Polymer Science SC Polymer Science GA FE330 UT WOS:A1991FE33000004 ER PT B AU SHUELY, WJ INCE, BS AF SHUELY, WJ INCE, BS BE SCHULZ, DN GLASS, JE TI RHEOLOGICAL PROPERTIES OF HIGH-MOLECULAR-WEIGHT POLY[(METHYL METHACRYLATE)-CO-ETHYLACRYLATE-CO-BUTYLACRYLATE] SOLUTIONS - INFLUENCE OF POLYMER SOLVENT INTERACTIONS SO POLYMERS AS RHEOLOGY MODIFIERS SE ACS SYMPOSIUM SERIES LA English DT Review CT SYMP AT THE 1988 NATIONAL MEETING OF THE AMERICAN CHEMICAL SOC : POLYMERS AS RHELOGY MODIFIERS CY SEP 10-15, 1989 CL MIAMI BEACH, FL SP AMER CHEM SOC, DIV POLYM MAT SCI & ENGN ID SWELL RP SHUELY, WJ (reprint author), USA,SMCCR,RSC-P,ABERDEEN PROVING GROUND,MD 21010, USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU AMER CHEMICAL SOC PI WASHINGTON PA WASHINGTON BN 0-8412-2009-3 J9 ACS SYM SER PY 1991 VL 462 BP 286 EP 300 PG 15 WC Chemistry, Applied; Engineering, Multidisciplinary; Polymer Science SC Chemistry; Engineering; Polymer Science GA BT44C UT WOS:A1991BT44C00017 ER PT J AU WINSLOW, RL KNAPP, AG AF WINSLOW, RL KNAPP, AG TI DYNAMIC-MODELS OF THE RETINAL HORIZONTAL CELL NETWORK SO PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY LA English DT Article ID TELEOST FISH RETINA; BIFURCATION-ANALYSIS; ELECTRICAL-PROPERTIES; LIGHT RESPONSIVENESS; MEMBRANE-PROPERTIES; PROLONGED DARKNESS; GOLDFISH RETINA; IONIC CURRENTS; DOPAMINE; MODULATION C1 UNIV MINNESOTA,DEPT PHYSIOL,MINNEAPOLIS,MN 55455. UNIV MINNESOTA,ARMY HIGH PERFORMANCE COMP RES CTR,MINNEAPOLIS,MN 55455. CAMBRIDGE NEUROSCI RES INC,CAMBRIDGE,MA 02139. FU NINDS NIH HHS [P01NS-17763-07] NR 55 TC 6 Z9 6 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0079-6107 J9 PROG BIOPHYS MOL BIO JI Prog. Biophys. Mol. Biol. PY 1991 VL 56 IS 2 BP 107 EP 133 DI 10.1016/0079-6107(91)90016-L PG 27 WC Biochemistry & Molecular Biology; Biophysics SC Biochemistry & Molecular Biology; Biophysics GA GG418 UT WOS:A1991GG41800002 PM 1947128 ER PT J AU HUHMAN, KL HEBERT, MA MEYERHOFF, JL BUNNELL, BN AF HUHMAN, KL HEBERT, MA MEYERHOFF, JL BUNNELL, BN TI PLASMA CYCLIC-AMP INCREASES IN HAMSTERS FOLLOWING EXPOSURE TO A GRADED FOOTSHOCK STRESSOR SO PSYCHONEUROENDOCRINOLOGY LA English DT Article ID CATECHOLAMINES; RATS AB To assess the utility of plasma cyclic AMP (cAMP) as a sensitive physiological index of an animal's arousal level, we exposed male hamsters to various intensities (0.0-2.0 mA) of a footshock stressor. The plasma cAMP response was directly related to stimulus intensity. Ratings of behavioral arousal were positively correlated with plasma cAMP values. We conclude that plasma cAMP may be a useful index of arousal. C1 UNIV GEORGIA,DEPT PSYCHOL,ATHENS,GA 30602. WALTER REED ARMY MED CTR,DEPT MED NEUROSCI,DIV NEUROPSYCHIAT,WASHINGTON,DC 20307. NR 18 TC 7 Z9 7 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0306-4530 J9 PSYCHONEUROENDOCRINO JI Psychoneuroendocrinology PY 1991 VL 16 IS 6 BP 559 EP 563 DI 10.1016/0306-4530(91)90039-V PG 5 WC Endocrinology & Metabolism; Neurosciences; Psychiatry SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry GA HJ389 UT WOS:A1991HJ38900010 PM 1667337 ER PT J AU GENOVESE, RF LU, XCM AF GENOVESE, RF LU, XCM TI EFFECTS OF MK-801 STEREOISOMERS ON SCHEDULE-CONTROLLED BEHAVIOR IN RATS SO PSYCHOPHARMACOLOGY LA English DT Article DE MK-801; TOLERANCE; OPERANT BEHAVIOR; RAT ID METHYL-D-ASPARTATE; NMDA RECEPTOR; ANTICONVULSANT MK-801; N-ALLYLNORMETAZOCINE; RHESUS-MONKEYS; PHENCYCLIDINE; ANTAGONISTS; BLOCKADE; BRAIN; ACQUISITION AB Behavioral effects of (+)MK-801 (0.03-0.32 mg/kg) and (-)MK-801 (0.32-3.20 mg/kg) were evaluated in rats using a multiple fixed-ratio, fixed-interval (FR20, FI2) schedule of food presentation. Both enantiomers produced dose-dependent decreases in response rate under the FR20 and in this respect (+)MK-801 was approximately ten times as potent as (-)MK-801. Under the FI2 schedule component, the (+) enantiomer produced substantial increases as well as decreases in response rate whereas the (-) enantiomer produced only decreases. When 0.178 mg/kg (+)MK-801 and 1.78 mg/kg (-)MK-801 were administered for 11 consecutive days, tolerance developed to the decrease in response rate under the FR20 schedule component. Tolerance to the effects of the (+) enantiomer under the FI2 schedule component was indicated by progressively larger increases in response rate than those observed during acute administration. These results support potential therapeutic applications of MK-801. RP GENOVESE, RF (reprint author), WALTER REED ARMY MED CTR,DEPT MED NEUROSCI,DIV NEUROPSYCHIAT,WASHINGTON,DC 20307, USA. NR 26 TC 17 Z9 17 U1 0 U2 0 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0033-3158 J9 PSYCHOPHARMACOLOGY JI Psychopharmacology PY 1991 VL 105 IS 4 BP 477 EP 480 DI 10.1007/BF02244366 PG 4 WC Neurosciences; Pharmacology & Pharmacy; Psychiatry SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry GA GN105 UT WOS:A1991GN10500005 PM 1771215 ER PT J AU KRANSDORF, MJ MOSER, RP MEIS, JM MEYER, CA AF KRANSDORF, MJ MOSER, RP MEIS, JM MEYER, CA TI FROM THE ARCHIVES OF THE AFIP - FAT-CONTAINING SOFT-TISSUE MASSES OF THE EXTREMITIES SO RADIOGRAPHICS LA English DT Article DE ANGIOMA; FAT; CT; FAT; MR STUDIES; HIBERNOMA; LIPOBLASTOMA; LIPOMA AND LIPOMATOSIS; LIPOSARCOMA; MYXOMA ID COMPUTED-TOMOGRAPHY; INFILTRATING ANGIOLIPOMA; PATHOLOGIC CORRELATION; INTRAMUSCULAR MYXOMA; MUSCULOSKELETAL NEOPLASMS; ELASTOFIBROMA DORSI; LIPOMATOUS TUMORS; ATYPICAL LIPOMA; CT APPEARANCE; MR AB The authors review the radiologic spectrum of fat-containing soft-tissue masses of the extremities, with emphasis on computed tomography, magnetic resonance imaging, and pathologic correlation. These masses include both common and uncommon, benign and malignant lesions, such as lipoma, intramuscular and intermuscular lipoma, neural fibrolipoma, lipoblastoma, lipomatosis, hibernoma, hemangioma, elastofibroma, and liposarcoma, as well as lesions that may mimic fat-containing soft-tissue masses. Imaging studies of fat-containing lesions will often allow a specific presumptive diagnosis. When a specific diagnosis is not possible, however, knowledge of the spectrum of fat-containing lesions will allow a suitably ordered differential diagnosis. C1 US ARMED FORCES INST PATHOL,DEPT SOFT TISSUE PATHOL,WASHINGTON,DC 20306. UNIFORMED SERV UNIV HLTH SCI,DEPT RADIOL & NUCL MED,BETHESDA,MD 20814. PENN STATE UNIV,MILTON S HERSHEY MED CTR,DEPT RADIOL,HERSHEY,PA 17033. WALTER REED ARMY MED CTR,DEPT RADIOL,WASHINGTON,DC 20307. RP KRANSDORF, MJ (reprint author), US ARMED FORCES INST PATHOL,DEPT RADIOL PATHOL,BLDG 54,RM M121,ALASKA & FERN STS,WASHINGTON,DC 20306, USA. NR 64 TC 84 Z9 85 U1 0 U2 3 PU RADIOLOGICAL SOC NORTH AMER PI EASTON PA 20TH AND NORTHAMPTON STS, EASTON, PA 18042 SN 0271-5333 J9 RADIOGRAPHICS JI Radiographics PD JAN PY 1991 VL 11 IS 1 BP 81 EP 106 PG 26 WC Radiology, Nuclear Medicine & Medical Imaging SC Radiology, Nuclear Medicine & Medical Imaging GA ET801 UT WOS:A1991ET80100009 PM 1996399 ER PT J AU REYNOLDS, PC HAHN, MB AF REYNOLDS, PC HAHN, MB TI EARLY DIAGNOSIS OF A SPINAL EPIDURAL ABSCESS SO REGIONAL ANESTHESIA LA English DT Article DE EPIDURAL; ABSCESS AB Epidural abscess is a neurologic emergency. Diagnosis may be difficult and costly to patients and health care providers in terms of time and money expended. We present a case of epidural abscess diagnosed in a cancer patient with an implanted epidural catheter. Diagnostic studies were performed that documented the presence of a spinal epidural abscess. Routine aspiration of an implanted epidural catheter facilitated the early diagnosis of epidural abscess in our patient prior to the performance of these studies. RP REYNOLDS, PC (reprint author), WALTER REED ARMY MED CTR,DEPT SURG,ANESTHESIA & OPERAT SERV,WASHINGTON,DC 20307, USA. NR 0 TC 17 Z9 17 U1 0 U2 0 PU CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS PI NEW YORK PA 650 AVENUE OF THE AMERICAS, NEW YORK, NY 10011 SN 0146-521X J9 REGION ANESTH JI Reg. Anesth. PD JAN-FEB PY 1991 VL 16 IS 1 BP 57 EP 58 PG 2 WC Anesthesiology SC Anesthesiology GA EY100 UT WOS:A1991EY10000013 PM 2007108 ER PT J AU BASKIN, SI THOMSEN, RH AF BASKIN, SI THOMSEN, RH TI THE EFFECTS OF AF-DX 116, A CARDIOSELECTIVE MUSCARINIC ANTAGONIST, ON THE NEGATIVE INOTROPIC ACTION OF ACETYLCHOLINE SO RESEARCH COMMUNICATIONS IN CHEMICAL PATHOLOGY AND PHARMACOLOGY LA English DT Article ID RECEPTOR ANTAGONIST; PROFILE; TISSUES; RAT AB In superfused left atria from male guinea pigs, rats, and rabbits, myocardial contractility was measured before and after addition of acetylcholine (ACh) and AF-DX 116 ((11[[2-[(diethylamino)methyl]-1-piperidinyl]-acetyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepine-6-) one), a selective muscarinic antagonist. Characteristic dose-response curves for acetylcholine showing greater negative inotropic response with dose were seen. Increasing AF-DX 116 concentrations reversed the negative inotropy of acetylcholine and, in fact, increased the inotropic response approximately 100% and 50% above the baseline contractile force in a dose-dependent manner in the guinea pig and rabbit, respectively. This increase in contractility following AF-DX 116 addition was not observed in rat atria. The capacity of AF-DX 116 to produce the positive inotropic response only occurred at concentrations above 1 x 10(-5) M. The positive inotropic response of AF-DX 116 was antagonized by dl-propranolol, which suggests that the administration of AF-DX 116 at higher concentrations may unmask the effect of norepinephrine released from underlying viable adrenergic terminals which exist in the left atria. RP BASKIN, SI (reprint author), USA,MED RES INST CHEM DEF,SGRD,UV,PB,ABERDEEN PROVING GROUND,MD 21010, USA. NR 18 TC 2 Z9 2 U1 0 U2 0 PU P J D PUBLICATIONS LTD PI WESTBURY PA PO BOX 966, WESTBURY, NY 11590 SN 0034-5164 J9 RES COMMUN CHEM PATH PD JAN PY 1991 VL 71 IS 1 BP 3 EP 16 PG 14 WC Pathology; Pharmacology & Pharmacy SC Pathology; Pharmacology & Pharmacy GA EV334 UT WOS:A1991EV33400002 PM 2024064 ER PT J AU TAN, A MILLER, JR AF TAN, A MILLER, JR TI TREND STUDIES OF STANDARD AND REGULAR GAUGE BLOCK SETS SO REVIEW OF SCIENTIFIC INSTRUMENTS LA English DT Article AB Trend studies of standard and regular gauge block sets were undertaken by studying their total deviations summed over individual blocks in a set. The standard sets exhibited volumetric shrinkage and wear but no volumetric expansions. The regular gauge block sets frequently exhibited expansions, mostly in the earlier and middle stages of their calibration history. The rates of total deviations were smaller for the standard sets than for the regular sets, and were the least for the carbide sets. The Pratt & Whitney gauge blocks showed a significantly larger shrinkage as compared with gauge blocks made by DoAll and other manufacturers. A factorial experiment with gauge blocks is proposed to separate the volumetric change from wear. C1 USA,TEST MEASUREMENT & DIAGNOST EQUIPMENT SUPPORT GRP,REDSTONE ARSENAL,AL 35898. RP TAN, A (reprint author), ALABAMA A&M UNIV,DEPT PHYS,NORMAL,AL 35762, USA. NR 16 TC 1 Z9 1 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0034-6748 J9 REV SCI INSTRUM JI Rev. Sci. Instrum. PD JAN PY 1991 VL 62 IS 1 BP 233 EP 237 DI 10.1063/1.1142313 PG 5 WC Instruments & Instrumentation; Physics, Applied SC Instruments & Instrumentation; Physics GA EQ607 UT WOS:A1991EQ60700036 ER PT J AU BAKER, JA KILLGORE, KJ KASUL, RL AF BAKER, JA KILLGORE, KJ KASUL, RL TI AQUATIC HABITATS AND FISH COMMUNITIES IN THE LOWER MISSISSIPPI RIVER SO REVIEWS IN AQUATIC SCIENCES LA English DT Review AB The Mississippi River ecosystem is, and probably has been for millions of years, home to a large and diverse community of freshwater fishes. The river is also an important inland artery for commerce, and its floodplain supports extensive agriculture and many urban and commercial areas. The ecosystem and the distribution and abundance of its aquatic habitats have changed greatly over geological history. Recent attempts to control the river have also produced changes in the ecosystem, and in many ways these changes are different from those that occurred naturally over the history of the river. Managing the aquatic ecosystem of the river requires an understanding of its ecological habitats, the biotic communities, and their interrelationships. This article examines the state of our knowledge of the lower Mississippi River ecosystem; it also delineates the aquatic habitats of the river and describes the communities of fish associated with them. C1 USA,ENGN WATERWAYS EXPT STN,3909 HALLS FERRY RD,VICKSBURG,MS 39180. NR 0 TC 80 Z9 82 U1 1 U2 9 PU CRC PRESS INC PI BOCA RATON PA 2000 CORPORATE BLVD NW, BOCA RATON, FL 33431 SN 0891-4117 J9 REV AQUAT SCI PY 1991 VL 3 IS 4 BP 313 EP 356 PG 44 WC Fisheries; Marine & Freshwater Biology; Oceanography SC Fisheries; Marine & Freshwater Biology; Oceanography GA ET491 UT WOS:A1991ET49100001 ER PT J AU RICHTERMENGE, JA COLBECK, SC JEZEK, KC AF RICHTERMENGE, JA COLBECK, SC JEZEK, KC TI RECENT PROGRESS IN SNOW AND ICE RESEARCH SO REVIEWS OF GEOPHYSICS LA English DT Review ID TERRESTRIAL GAMMA-RADIATION; FRESH-WATER ICE; POLYCRYSTALLINE ICE; SEA-ICE; SURFACE CHARACTERISTICS; NORTHERN-HEMISPHERE; FRACTURE-TOUGHNESS; MICROWAVE EMISSION; RADAR ALTIMETRY; CONTINENTAL ICE AB Snow and ice research during the past quadrennial covers a wide range of topics varying from the climatic effects of large ice sheets and sea ice covers to applied problems such as the icing of power lines and communication facilities. This review focuses in more detail on three topics of the many subjects investigated to provide a more coherent look at the advances achieved and prospects for the future. These are: the influences of layers in seasonal snow covers; research in ice mechanics on freshwater and sea ice; and remote sensing of polar ice sheets. These topics provide useful examples of the general needs in snow and ice research applicable to most areas, e.g. better representation in models of detailed processes, careful controlled laboratory experiments to quantify processes, and field studies to provide the appropriate context for interpretation of processes from remote sensing. C1 OHIO STATE UNIV,BYRD POLAR RES CTR,COLUMBUS,OH 43210. RP RICHTERMENGE, JA (reprint author), USA,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. NR 355 TC 4 Z9 4 U1 0 U2 11 PU AMER GEOPHYSICAL UNION PI WASHINGTON PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 SN 8755-1209 J9 REV GEOPHYS JI Rev. Geophys. PY 1991 VL 29 SU S BP 218 EP 226 PN 1 PG 9 WC Geochemistry & Geophysics SC Geochemistry & Geophysics GA FX961 UT WOS:A1991FX96100031 ER PT J AU BRANTON, MH JOHNSON, SC BROOKE, JD HASBARGEN, JA AF BRANTON, MH JOHNSON, SC BROOKE, JD HASBARGEN, JA TI PERITONITIS DUE TO RHIZOPUS IN A PATIENT UNDERGOING CONTINUOUS AMBULATORY PERITONEAL-DIALYSIS SO REVIEWS OF INFECTIOUS DISEASES LA English DT Review ID FUNGAL PERITONITIS; MUCORMYCOSIS AB A 61-year-old man who had end-stage renal disease secondary to diabetes mellitus and hypertension developed peritonitis due to infection with Rhizopus as a complication of receiving continuous ambulatory peritoneal dialysis (CAPD). At the onset of infection, the patient was neither acidemic nor hyperglycemic; in addition, deferoxamine had not been administered and Elastoplast dressings had not been applied. The infection occurred after the technique for disinfection of the catheter used for CAPD had been changed. The catheter was removed, and therapy with amphotericin B was initiated. Although the patient died of apparently unrelated causes, an autopsy revealed active fungal infection with multiple abscesses and superficial invasion of the ileal wall. C1 WALTER REED ARMY MED CTR,DEPT MED,INFECT DIS SERV,WASHINGTON,DC 20307. WALTER REED ARMY MED CTR,DEPT MED,NEPHROL SERV,WASHINGTON,DC 20307. FITZSIMONS ARMY MED CTR,DEPT PATHOL,AURORA,CO 80045. FITZSIMONS ARMY MED CTR,DEPT MED,NEPHROL SERV,AURORA,CO 80045. NR 10 TC 21 Z9 23 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0162-0886 J9 REV INFECT DIS PD JAN-FEB PY 1991 VL 13 IS 1 BP 19 EP 21 PG 3 WC Immunology; Microbiology SC Immunology; Microbiology GA EU520 UT WOS:A1991EU52000004 PM 2017628 ER PT J AU COSGRIFF, TM AF COSGRIFF, TM TI MECHANISMS OF DISEASE IN HANTAVIRUS INFECTION - PATHOPHYSIOLOGY OF HEMORRHAGIC-FEVER WITH RENAL SYNDROME SO REVIEWS OF INFECTIOUS DISEASES LA English DT Review ID TUMOR NECROSIS FACTOR; PLATELET-ACTIVATING FACTOR; VASCULAR ENDOTHELIAL-CELLS; FACTOR CACHECTIN; IMMUNE-COMPLEX; SEPTIC SHOCK; INTERLEUKIN-1; PATHOGENESIS; ENDOTOXIN; PATHWAY AB Hemorrhagic fever with renal syndrome (HFRS) is an acute viral disease that occurs over wide areas of Europe and Asia. Hantaviruses are the cause of this syndrome. The hallmark of HFRS is the traid of fever, hemorrhage, and renal failure. In its severe form it is associated with significant mortality. The syndrome evolves through five phases: febrile, hypotensive, oliguric, diuretic, and convalescent. The central physiologic derangement in HFRS is vascular dysfunction, manifested by impaired vascular tone and increased vascular permeability. The systemic effects of this dysfunction account for the occurrence of hypotension and shock, while local effects are probably important in the development of renal failure. Shock in HFRS has distributive and oligemic features, while renal failure has features of acute tubular necrosis. Hemorrhage is a consequence of vascular injury and a deficit of functional platelets. Vascular and platelet dysfunction are both compounded by uremia. Disseminated intravascular coagulation contributes to hemorrhage in some patients. Although hantaviruses are infectious for endothelial cells and may cause direct injury, a large body of evidence suggests that immune mechanisms play an important role in the pathogenesis of HFRS. C1 USA, MED RES INST INFECT DIS, DIV MED, FREDERICK, MD 21701 USA. NR 134 TC 131 Z9 136 U1 0 U2 7 PU UNIV CHICAGO PRESS PI CHICAGO PA 1427 E 60TH ST, CHICAGO, IL 60637-2954 USA SN 0162-0886 J9 REV INFECT DIS PD JAN-FEB PY 1991 VL 13 IS 1 BP 97 EP 107 PG 11 WC Immunology; Microbiology SC Immunology; Microbiology GA EU520 UT WOS:A1991EU52000017 PM 1673261 ER PT J AU MENNING, BW AF MENNING, BW TI FROM SERF TO RUSSIAN SOLDIER - WIRTSCHAFTER,EK SO RUSSIAN REVIEW LA English DT Book Review RP MENNING, BW (reprint author), SOVIET ARMY STUDIES OFF,FT LEAVENWORTH,KS, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU OHIO STATE UNIV PRESS PI COLUMBUS PA 1050 CARMACK RD, COLUMBUS, OH 43210 SN 0036-0341 J9 RUSS REV JI Russ. Rev. PD JAN PY 1991 VL 50 IS 1 BP 93 EP 94 DI 10.2307/130224 PG 2 WC History SC History GA ET797 UT WOS:A1991ET79700018 ER PT J AU KIPP, JW AF KIPP, JW TI THE SOVIET NAVAL THREAT TO EUROPE - MILITARY AND POLITICAL DIMENSIONS - WATSON,BW, WATSON,SM SO RUSSIAN REVIEW LA English DT Book Review RP KIPP, JW (reprint author), SOVIET ARMY STUDIES OFF,FT LEAVENWORTH,KS, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU OHIO STATE UNIV PRESS PI COLUMBUS PA 1050 CARMACK RD, COLUMBUS, OH 43210 SN 0036-0341 J9 RUSS REV JI Russ. Rev. PD JAN PY 1991 VL 50 IS 1 BP 115 EP 116 DI 10.2307/130242 PG 2 WC History SC History GA ET797 UT WOS:A1991ET79700036 ER PT J AU LIN, SS AF LIN, SS TI OXIDATIVE STABILIZATION IN PRODUCTION OF PITCH BASED CARBON-FIBER SO SAMPE JOURNAL LA English DT Article AB Stabilization is the most time consuming step in the production of pitch based carbon fiber. Stabilization consists of the oxidization of melt-spun fiber to ensure dimensional and structural stability during the carbonization required to produce finished carbon fiber. The chemical and structural changes associated with stabilization are reviewed and the parameters affecting this process are examined. Finally, the prospects for better or lower cost carbon fiber through improved stabilization processing are considered. RP LIN, SS (reprint author), USA,MAT TECHNOL LAB,WATERTOWN,MA 02172, USA. NR 0 TC 15 Z9 16 U1 0 U2 3 PU SAMPE PUBLISHERS PI COVINA PA 1161 PARKVIEW DRIVE, COVINA, CA 91722 SN 0091-1062 J9 SAMPE J JI Sampe J. PD JAN-FEB PY 1991 VL 27 IS 1 BP 9 EP 14 PG 6 WC Engineering, Multidisciplinary; Materials Science, Multidisciplinary SC Engineering; Materials Science GA EQ160 UT WOS:A1991EQ16000003 ER PT J AU PRICE, GR KALB, JT AF PRICE, GR KALB, JT TI A NEW APPROACH TO A DAMAGE RISK CRITERION FOR WEAPONS IMPULSES SO SCANDINAVIAN AUDIOLOGY LA English DT Article; Proceedings Paper CT 21ST NORDIC CONGRESS OF MILITARY MEDICINE : EFFECTS OF NOISE AND BLASTS CY MAY 30-JUN 02, 1990 CL OSLO, NORWAY ID HAZARD; NOISE AB Existing damage-risk criteria for weapons impulses suffer from their lack of a theoretical basis, thereby limiting their generalizability and utility. Furthermore, a number of studies now indicate that they may be inaccurate for impulses with energy in the low frequency region (Dancer & al., 1985; Patterson & al., 1985; Price & al., 1989). We have approached the problem by modeling the ear mathematically as a means of gaining insight into the loss processes. In the model, the external and middle ears are linear at lower intensities; however, the stapes displacement is limited to 20 microns, as would be expected on anatomical/physical grounds. Susceptibility, in the inner ear, is modeled as mechanical stress, a function of basilar membrane displacement and number of flex cycles. The model, which is executable on a PC-based computer, reproduces the data on the ear that can be measured at lower intensities. It also ranks the known hazard from impulses in the correct order, explains the finding of loss in mid-cochlea regardless of spectral location of the weapons impulse, and suggests that the greatest hazard comes from that portion of the acoustic wave in which pressures cross through ambient and at a rate consistent with energy in the mid-range. Because the model is theoretically based, it has the potential for use as the basis for a damage risk criterion for impulse noise as well as for a design criterion for weapons. RP PRICE, GR (reprint author), USA,HUMAN ENGN LAB,ABERDEEN PROVING GROUND,MD 21005, USA. NR 23 TC 0 Z9 0 U1 0 U2 4 PU SCANDINAVIAN UNIVERSITY PRESS PI OSLO PA PO BOX 2959 TOYEN, JOURNAL DIVISION CUSTOMER SERVICE, N-0608 OSLO, NORWAY SN 0105-0397 J9 SCAND AUDIOL JI Scand. Audiol. PY 1991 SU 34 BP 21 EP 37 PG 17 WC Otorhinolaryngology SC Otorhinolaryngology GA FQ910 UT WOS:A1991FQ91000003 ER PT J AU PRICE, GR AF PRICE, GR TI FIRING RECOILLESS WEAPONS FROM ENCLOSURES SO SCANDINAVIAN AUDIOLOGY LA English DT Article; Proceedings Paper CT 21ST NORDIC CONGRESS OF MILITARY MEDICINE : EFFECTS OF NOISE AND BLASTS CY MAY 30-JUN 02, 1990 CL OSLO, NORWAY AB The problem. Recoilless weapons commonly release a great deal of energy rearward in the immediate vicinity of the crew. If such weapons are fired from within structures, there is concern that in addition to the acoustic hazard to the ear or other organs, there might be hazard associated with flying debris or even structural collapse. Studies. Two studies were conducted to evaluate such hazards by remotely firing a total of 24 rounds from the 90 mm recoilless rifle, LAW, TOW, and DRAGON weapons systems from within enclosures (Price, 1978; Shank & Garinther, 1975). The structures, selected from available buildings, were made of various materials (reinforced concrete, masonry, sandbags, and wood) and ranged in volume from 14m3 to 161 m3 with venting areas from 2.9 m2 to 11 m2. Data included pressure histories, motion pictures of the structures and small objects placed in the room, and physiological data from 32 goats (tissue/organ system damage) and 8 cats (hearing loss measures). Results and conclusions. At the firer's locations, peak pressures ranged from 178 to 189 dB and B-durations ranged from 28 to 376 msec. Although the firings commonly produced some structural damage, none of the firings caused structural collapse or induced tissue damage to non-auditory organs. Ear drum rupture did occur in 5 goats and the cat ears exposed with no hearing protection did show permanent hearing losses. Of the cat ears exposed with hearing protection (EAR plugs), only one showed a permanent loss. RP PRICE, GR (reprint author), USA,HUMAN ENGN LAB,ABERDEEN PROVING GROUND,MD 21005, USA. NR 7 TC 0 Z9 0 U1 0 U2 0 PU SCANDINAVIAN UNIVERSITY PRESS PI OSLO PA PO BOX 2959 TOYEN, JOURNAL DIVISION CUSTOMER SERVICE, N-0608 OSLO, NORWAY SN 0105-0397 J9 SCAND AUDIOL JI Scand. Audiol. PY 1991 SU 34 BP 39 EP 48 PG 10 WC Otorhinolaryngology SC Otorhinolaryngology GA FQ910 UT WOS:A1991FQ91000004 ER PT J AU FOBERG, U FRYDEN, A ISAKSSON, B JAHRLING, P JOHNSON, A MCKEE, K NIKLASSON, B NORMANN, B PETERS, C BENGTSSON, M AF FOBERG, U FRYDEN, A ISAKSSON, B JAHRLING, P JOHNSON, A MCKEE, K NIKLASSON, B NORMANN, B PETERS, C BENGTSSON, M TI VIRAL HEMORRHAGIC-FEVER IN SWEDEN - EXPERIENCES FROM MANAGEMENT OF A CASE SO SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES LA English DT Article ID MARBURG-VIRUS DISEASE AB The first recognized case in Scandinavia with potential man to man transmission of viral haemorrhagic fever occurred in Linkoping, Sweden, in January 1990. Following a visit to Kenya a 21-year-old male student suffered a very severe illness including extremely prolonged high grade fever, rash, disseminated intravascular coagulation with thrombocytopenia and severe bleedings. This necessitated one month of intensive care support including respirator treatment. The patient was discharged after 2 1/2 months in good condition, with a partial femoral nerve paresis. About 100 medical personnel were exposed to aerosol or blood before a strict containment regimen was established. No secondary cases occurred. C1 LINKOPING UNIV HOSP,FAC HLTH SCI,DEPT CLIN BACTERIOL,S-58185 LINKOPING,SWEDEN. NATL BACTERIOL LAB,DEPT VIROL,S-10521 STOCKHOLM,SWEDEN. LINKOPING UNIV HOSP,FAC HLTH SCI,DEPT ANAESTHESIOL,S-58185 LINKOPING,SWEDEN. USA,MED RES INST INFECT DIS,FT DETRICK,FREDERICK,MD 21701. RP FOBERG, U (reprint author), LINKOPING UNIV HOSP,FAC HLTH SCI,DEPT INFECT DIS,S-58185 LINKOPING,SWEDEN. NR 25 TC 10 Z9 10 U1 0 U2 1 PU SCANDINAVIAN UNIVERSITY PRESS PI OSLO PA PO BOX 2959 TOYEN, JOURNAL DIVISION CUSTOMER SERVICE, N-0608 OSLO, NORWAY SN 0036-5548 J9 SCAND J INFECT DIS JI Scand. J. Infect. Dis. PY 1991 VL 23 IS 2 BP 143 EP 151 DI 10.3109/00365549109023392 PG 9 WC Infectious Diseases SC Infectious Diseases GA FK863 UT WOS:A1991FK86300004 PM 1853161 ER PT J AU AKESSON, A MACELLARO, A TULL, P WILLIAMS, JC NORLANDER, L AF AKESSON, A MACELLARO, A TULL, P WILLIAMS, JC NORLANDER, L TI EPIDEMIOLOGY OF Q-FEVER IN SWEDEN SO SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES LA English DT Article AB Q fever is known to be a worldwide disease, with Sweden supposed to be one of a few exceptions. The purpose of this pilot study was to elucidate whether or not a potential risk group for obtaining Q fever in Sweden was seropositive to the causative agent Coxiella burnetii. Blood samples were collected from sheep farmers on the island of Gotland, and from members of their families. Serum samples were examined by ELISA for the presence of antibodies against C. burnetii, phases I and II. Positive reactions were confirmed with Western blot analysis. It was found that 30% of the study group were seropositive to C. burnetii, thus indicating that Q fever is endemic in this area of Sweden. C1 NATL DEF RES ESTAB,DIV MICROBIOL,UMEA,SWEDEN. VISBY HOSP,DEPT INFECT DIS,VISBY,SWEDEN. USA,MED RES INST INFECT DIS,FT DETRICK,FREDERICK,MD 21701. RP AKESSON, A (reprint author), KALMAR HOSP,DEPT INFECT DIS,S-39185 KALMAR,SWEDEN. NR 8 TC 12 Z9 12 U1 0 U2 0 PU SCANDINAVIAN UNIVERSITY PRESS PI OSLO PA PO BOX 2959 TOYEN, JOURNAL DIVISION CUSTOMER SERVICE, N-0608 OSLO, NORWAY SN 0036-5548 J9 SCAND J INFECT DIS JI Scand. J. Infect. Dis. PY 1991 VL 23 IS 2 BP 153 EP 157 DI 10.3109/00365549109023393 PG 5 WC Infectious Diseases SC Infectious Diseases GA FK863 UT WOS:A1991FK86300005 PM 1853162 ER PT J AU THOMPSON, IM ZEIDMAN, EJ AF THOMPSON, IM ZEIDMAN, EJ TI PRESENTATION AND CLINICAL COURSE OF PATIENTS ULTIMATELY SUCCUMBING TO CARCINOMA OF THE PROSTATE SO SCANDINAVIAN JOURNAL OF UROLOGY AND NEPHROLOGY LA English DT Article DE PROSTATE CANCER; DIGITAL RECTAL EXAMINATION; MORTALITY ID CANCER AB Ninety-six patients who expired due to carcinoma of the prostate were identified within the primary treatment area of Brooke Army Medical Center between the years of 1981 and 1988. Although 71 patients were noted to have abnormal prostate examinations at the time of diagnosis, 11 had been noted to have a palpably normal prostate within three years of tumor diagnosis. Twenty-four patients had a palpably normal prostate at the time of diagnosis. Fifteen patients had been previously noted to have an abnormal prostate but biopsy in 11 of these had been benign. These data suggest that digital rectal examination of the prostate will not detect a number of patients who will ultimately die of carcinoma of the prostate. RP THOMPSON, IM (reprint author), BROOKE ARMY MED CTR,UROL SERV,FT SAM HOUSTON,TX 78234, USA. NR 5 TC 6 Z9 6 U1 0 U2 0 PU SCANDINAVIAN UNIVERSITY PRESS PI OSLO PA PO BOX 2959 TOYEN, JOURNAL DIVISION CUSTOMER SERVICE, N-0608 OSLO, NORWAY SN 0036-5599 J9 SCAND J UROL NEPHROL JI Scand. J. Urol. Nephrol. PY 1991 VL 25 IS 2 BP 111 EP 114 DI 10.3109/00365599109024543 PG 4 WC Urology & Nephrology SC Urology & Nephrology GA FP095 UT WOS:A1991FP09500005 PM 1871554 ER PT J AU DOWDING, RJ TAUER, KJ AF DOWDING, RJ TAUER, KJ TI STRAIN AGING IN TUNGSTEN HEAVY ALLOYS SO SCRIPTA METALLURGICA ET MATERIALIA LA English DT Article ID W-NI-FE; PRECIPITATION RP DOWDING, RJ (reprint author), USA,MAT TECHNOL LAB,MAT PRODUCIBIL BRANCH,ARSENAL ST,WATERTOWN,MA 02172, USA. RI Dowding, Robert/F-1469-2015 OI Dowding, Robert/0000-0002-4763-2131 NR 22 TC 5 Z9 6 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0956-716X J9 SCRIPTA METALL MATER JI Scr. Metall. Materialia PD JAN PY 1991 VL 25 IS 1 BP 121 EP 126 DI 10.1016/0956-716X(91)90365-8 PG 6 WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering SC Materials Science; Metallurgy & Metallurgical Engineering GA EQ988 UT WOS:A1991EQ98800023 ER PT J AU STULL, MA MOSER, RP KRANSDORF, MJ BOGUMILL, GP NELSON, MC AF STULL, MA MOSER, RP KRANSDORF, MJ BOGUMILL, GP NELSON, MC TI MAGNETIC-RESONANCE APPEARANCE OF PERIPHERAL-NERVE SHEATH TUMORS SO SKELETAL RADIOLOGY LA English DT Article DE NEURAL TUMORS; MAGNETIC RESONANCE; PERIPHERAL NERVES ID SOFT-TISSUE MASSES; MALIGNANT SCHWANNOMA; CT AB Magnetic resonance imaging (MRI) was used to evaluate 22 histologically proven peripheral nerve sheath tumors approximately two-thirds of which arose in the lower extremity. The histologic distribution was as follows: 12 schwannomas, 7 neurofibromas, and 3 malignant peripheral nerve sheath tumors (2 of which occurred in patients with neurofibromatosis). Most lesions demonstrated an intermediate to moderately bright signal on T1-weighted images and were minimally inhomogeneous. All lesions were moderately bright on proton-density-weighted images and bright on T2-weighted images, again with variable inhomogeneity. The extent of the tumor was best assessed on proton-density- and T2-weighted images. Smooth margins were noted in 19 lesions. Of the 3 remaining lesions, 2 were malignant (but had been subjected to biopsy prior to MRI), and the other lesion was a plexiform neurofibroma. MRI accurately determined the relationship between the lesion and the adjacent neurovascular structures and muscles, thereby assisting surgical management. On MRI, 5 lesions demonstrated coexistent subtle muscle atrophy along the longitudinal axis of surrounding or distally innervated musculature. This latter finding, together with the presence of a tumor in the vicinity of a large nerve trunk, suggests a peripheral nerve sheath neoplasm. C1 USAF,INST PATHOL,DEPT RADIOL PATHOL,WASHINGTON,DC 20306. GEORGETOWN UNIV,MED CTR,DEPT RADIOL,WASHINGTON,DC 20007. GEORGETOWN UNIV,MED CTR,DEPT ORTHOPED SURG,WASHINGTON,DC 20007. UNIFORMED SERV UNIV HLTH SCI,DEPT RADIOL & NUCL MED,BETHESDA,MD 20814. PENN STATE UNIV,MILTON S HERSHEY MED CTR,DEPT RADIOL,HERSHEY,PA 17033. WALTER REED ARMY MED CTR,DEPT RADIOL,WASHINGTON,DC 20307. NR 24 TC 113 Z9 120 U1 0 U2 0 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0364-2348 J9 SKELETAL RADIOL JI Skeletal Radiol. PY 1991 VL 20 IS 1 BP 9 EP 14 PG 6 WC Orthopedics; Radiology, Nuclear Medicine & Medical Imaging SC Orthopedics; Radiology, Nuclear Medicine & Medical Imaging GA ET284 UT WOS:A1991ET28400003 PM 1900374 ER PT J AU KRANSDORF, MJ MCFARLAND, DR MOSER, RP VENBRUX, AC AF KRANSDORF, MJ MCFARLAND, DR MOSER, RP VENBRUX, AC TI DIAGNOSIS - ARTERIOVENOUS MALFORMATION (ARTERIOVENOUS HEMANGIOMA) OF THE DISTAL THIGH WITH BONE INVOLVEMENT SO SKELETAL RADIOLOGY LA English DT Article C1 USAF,INST PATHOL,DEPT RADIOL PATHOL,WASHINGTON,DC 20306. WALTER REED ARMY MED CTR,DEPT RADIOL,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,DEPT RADIOL & NUCL MED,BETHESDA,MD 20814. PENN STATE UNIV,MILTON S HERSHEY MED CTR,DEPT RADIOL,HERSHEY,PA 17033. NR 7 TC 7 Z9 7 U1 0 U2 0 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0364-2348 J9 SKELETAL RADIOL JI Skeletal Radiol. PY 1991 VL 20 IS 1 BP 63 EP 65 PG 3 WC Orthopedics; Radiology, Nuclear Medicine & Medical Imaging SC Orthopedics; Radiology, Nuclear Medicine & Medical Imaging GA ET284 UT WOS:A1991ET28400013 PM 2000508 ER PT J AU WHITAKER, MD JELINEK, JS KRANSDORF, MJ MOSER, RP BROWER, AC AF WHITAKER, MD JELINEK, JS KRANSDORF, MJ MOSER, RP BROWER, AC TI ARTHRITIS OF THE WRIST DUE TO MYCOBACTERIUM AVIUM-INTRACELLULARE - CASE REP ORT 653 SO SKELETAL RADIOLOGY LA English DT Article ID TUBERCULOSIS; DIAGNOSIS; JOINTS; BONES C1 WALTER REED ARMY MED CTR,DEPT RADIOL,WASHINGTON,DC 20307. UNIFORMED SERV UNIV HLTH SCI,DEPT RADIOL,BETHESDA,MD 20814. NR 13 TC 9 Z9 9 U1 0 U2 0 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0364-2348 J9 SKELETAL RADIOL JI Skeletal Radiol. PY 1991 VL 20 IS 4 BP 291 EP 293 PG 3 WC Orthopedics; Radiology, Nuclear Medicine & Medical Imaging SC Orthopedics; Radiology, Nuclear Medicine & Medical Imaging GA FL912 UT WOS:A1991FL91200010 PM 1853223 ER PT J AU SOLOMON, Z MIKULINCER, M WAYSMAN, M MARLOWE, DH AF SOLOMON, Z MIKULINCER, M WAYSMAN, M MARLOWE, DH TI DELAYED AND IMMEDIATE ONSET POSTTRAUMATIC-STRESS-DISORDER .1. DIFFERENTIAL CLINICAL CHARACTERISTICS SO SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY LA English DT Article ID VIETNAM VETERANS; SELF-EFFICACY; COMBAT STRESS; VALIDATION; WAR; SCL-90; SCALE; PTSD C1 TEL AVIV UNIV,DEPT SOCIAL WORK,IL-69978 TEL AVIV,ISRAEL. WALTER REED ARMY MED CTR,DEPT MIL PSYCHIAT,WASHINGTON,DC 20307. BAR ILAN UNIV,DEPT PSYCHOL,RAMAT GAN,ISRAEL. RP SOLOMON, Z (reprint author), ISRAEL DEF FORCES,MED CORPS,DEPT MENTAL HLTH,RES BRANCH,POB 02149,TEL AVIV,ISRAEL. NR 29 TC 23 Z9 23 U1 0 U2 0 PU SPRINGER VERLAG PI NEW YORK PA 175 FIFTH AVE, NEW YORK, NY 10010 SN 0933-7954 J9 SOC PSYCH PSYCH EPID JI Soc. Psychiatry Psychiatr. Epidemiol. PY 1991 VL 26 IS 1 BP 1 EP 7 DI 10.1007/BF00783573 PG 7 WC Psychiatry SC Psychiatry GA EV797 UT WOS:A1991EV79700001 PM 2006437 ER PT J AU MARION, GM MORENO, JM OECHEL, WC AF MARION, GM MORENO, JM OECHEL, WC TI FIRE SEVERITY, ASH DEPOSITION, AND CLIPPING EFFECTS ON SOIL NUTRIENTS IN CHAPARRAL SO SOIL SCIENCE SOCIETY OF AMERICA JOURNAL LA English DT Article ID NITROGEN; FOREST AB Fire may affect soil nutrient status by direct addition of nutrients and by indirectly altering the soil environment. The objective of this study was to examine how fire severity, ash deposition, and clipping affect posttreatment soil nutrient status. There were eight experimental treatments designed to examine increasing fire severity, ash (nutrient) addition independent of fire severity, clipping to study competition for nutrients per se, and untreated controls. Fire severity affected both the quality and quantity of ash. Increasing fire severity increased the concentrations of Mg and K and decreased the concentrations of NH4-N and NO3-N in the ash. As fire severity increased, there was an increasing recovery of ash relative to standing biomass (10-18 g kg-1). Fire increased the availability of all nutrients (NH4-N, NO3-N, PO4-P, Ca, Mg and K). This nutrient enhancement was largely restricted to the surface soil (0-5 cm); only soluble N appeared to increase in the subsurface soil (5-10 cm). The soil quantities of NH4-N increased and NO3-N decreased with increasing fire severity, suggesting either a direct addition of variable amounts of these N ions or an indirect effect on postfire nitrification rates. Clipping had no effect on enhancing soil nutrient availability. The apparent recovery of the basic cations in the water extracts of the ash samples was in the order: K >> Mg > Ca; this was different from the subsequent recovery in the soil: Ca > K > Mg. It was hypothesized that the relative recovery of basic cations in the water extracts of the ash samples was controlled by the solubility of Ca, Mg, and K salts. C1 SAN DIEGO STATE UNIV,DEPT BIOL,SAN DIEGO,CA 92182. UNIV COMPLUTENSE MADRID,DEPT ECOL,E-28040 MADRID,SPAIN. RP MARION, GM (reprint author), USA,COLD REG RES & ENGN LAB,72 LYME RD,HANOVER,NH 03755, USA. RI Oechel, Walter/F-9361-2010; Moreno, JOSE/M-5578-2015 OI Oechel, Walter/0000-0002-3504-026X; Moreno, JOSE/0000-0002-3729-9523 NR 22 TC 64 Z9 69 U1 2 U2 20 PU SOIL SCI SOC AMER PI MADISON PA 677 SOUTH SEGOE ROAD, MADISON, WI 53711 SN 0361-5995 J9 SOIL SCI SOC AM J JI Soil Sci. Soc. Am. J. PD JAN-FEB PY 1991 VL 55 IS 1 BP 235 EP 240 PG 6 WC Soil Science SC Agriculture GA FA732 UT WOS:A1991FA73200040 ER PT J AU BLANK, S AF BLANK, S TI UNCERTAINTY AND CONTROL - FUTURE SOVIET AND AMERICAN STRATEGY - CIMBALA,SJ SO SOVIET STUDIES LA English DT Book Review RP BLANK, S (reprint author), USA,COLL WAR,WASHINGTON,DC 20310, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU CARFAX PUBL CO PI ABINGDON PA PO BOX 25, ABINGDON, OXFORDSHIRE, ENGLAND OX14 3UE SN 0038-5859 J9 SOV STUD PY 1991 VL 43 IS 1 BP 194 EP 195 PG 2 WC Area Studies; Economics SC Area Studies; Business & Economics GA EV863 UT WOS:A1991EV86300017 ER PT J AU REGISTER, LF LITTLEJOHN, MA STROSCIO, MA AF REGISTER, LF LITTLEJOHN, MA STROSCIO, MA TI PATH-INTEGRAL MONTE-CARLO CALCULATION OF FREE AND CONFINED CARRIER REAL SELF-ENERGIES AT NONZERO TEMPERATURES SO SUPERLATTICES AND MICROSTRUCTURES LA English DT Article ID POLARON C1 N CAROLINA STATE UNIV,DEPT ELECT & COMP ENGN,RALEIGH,NC 27695. USA,RES OFF,RES TRIANGLE PK,NC 27709. NR 15 TC 0 Z9 0 U1 0 U2 0 PU ACADEMIC PRESS LTD PI LONDON PA 24-28 OVAL RD, LONDON, ENGLAND NW1 7DX SN 0749-6036 J9 SUPERLATTICE MICROST JI Superlattices Microstruct. PY 1991 VL 10 IS 1 BP 47 EP 50 DI 10.1016/0749-6036(91)90145-H PG 4 WC Physics, Condensed Matter SC Physics GA FZ178 UT WOS:A1991FZ17800008 ER PT J AU STROSCIO, MA KIM, KW RUDIN, S AF STROSCIO, MA KIM, KW RUDIN, S TI BOUNDARY-CONDITIONS FOR ELECTRON-LO-PHONON INTERACTION IN POLAR SEMICONDUCTOR QUANTUM WIRES SO SUPERLATTICES AND MICROSTRUCTURES LA English DT Article ID SUPERLATTICES; SCATTERING; MODES C1 N CAROLINA STATE UNIV,DEPT ELECT & COMP ENGN,RALEIGH,NC 27695. USA,ELECTR TECHNOL & DEVICES LAB,FT MONMOUTH,NJ 07703. RP STROSCIO, MA (reprint author), USA,RES OFF,RES TRIANGLE PK,NC 27709, USA. NR 15 TC 8 Z9 8 U1 0 U2 0 PU ACADEMIC PRESS LTD PI LONDON PA 24-28 OVAL RD, LONDON, ENGLAND NW1 7DX SN 0749-6036 J9 SUPERLATTICE MICROST JI Superlattices Microstruct. PY 1991 VL 10 IS 1 BP 55 EP 58 DI 10.1016/0749-6036(91)90147-J PG 4 WC Physics, Condensed Matter SC Physics GA FZ178 UT WOS:A1991FZ17800010 ER PT J AU SINGLETON, J GREENE, SK GOLDING, TD PEPPER, M SKIERBISZEWSKI, C WISNIEWSKI, P VANDERWEL, PJ VANTHOR, PHE DINAN, J AF SINGLETON, J GREENE, SK GOLDING, TD PEPPER, M SKIERBISZEWSKI, C WISNIEWSKI, P VANDERWEL, PJ VANTHOR, PHE DINAN, J TI MAGNETOTRANSPORT IN HIGH MOBILITY INSB-CDTE HETEROJUNCTIONS - ELECTRIC SPIN-SPLITTING OF SUBBANDS AND HIGH-PRESSURE EFFECTS SO SUPERLATTICES AND MICROSTRUCTURES LA English DT Article C1 CATHOLIC UNIV NIJMEGEN,MAT RES INST,6525 ED NIJMEGEN,NETHERLANDS. UNIV CAMBRIDGE,CAVENDISH LAB,CAMBRIDGE CB3 0HE,ENGLAND. POLISH ACAD SCI,UNIPRESS,PL-01142 WARSAW,POLAND. USA,CTR NIGHT VIS & ELECTRO OPT,AMSEL,RD,NV,IT,FT BELVOIR,VA 22060. RP SINGLETON, J (reprint author), CATHOLIC UNIV NIJMEGEN,HIGH FIELD MAGNET LAB,6525 ED NIJMEGEN,NETHERLANDS. NR 13 TC 4 Z9 4 U1 0 U2 0 PU ACADEMIC PRESS LTD PI LONDON PA 24-28 OVAL RD, LONDON, ENGLAND NW1 7DX SN 0749-6036 J9 SUPERLATTICE MICROST JI Superlattices Microstruct. PY 1991 VL 9 IS 1 BP 51 EP 54 DI 10.1016/0749-6036(91)90092-6 PG 4 WC Physics, Condensed Matter SC Physics GA FA657 UT WOS:A1991FA65700012 ER PT J AU LAREAU, RT BUSER, CH SAVIN, W AF LAREAU, RT BUSER, CH SAVIN, W TI PEAK IDENTIFICATION FOR MASS-SPECTROSCOPY SO SURFACE AND INTERFACE ANALYSIS LA English DT Article ID SPECTRA; SIMS AB Quick, accurate identification of mass spectral peaks is essential, whether the sample is in a gas, liquid or solid state. Often, the mass-filtered ion spectra include peaks due to atomic, molecular, cluster or multiply charged species. The computer program discussed herein will provide an aid to the mass spectroscopist in identifying: (1) an unknown/interference mass peak; (2) possible overlapping (non-resolvable) mass species; (3) the required mass resolution necessary to separate neighboring mass species. Other advantages include user selectable species, PC compatible software, unlimited mass range, and unlimited number of variables. Examples will be presented for samples analyzed by secondary ion mass spectrometry (SIMS) and glow discharge mass spectrometry (GDMS), as well as indications for its use in general organic mass spectrometry. C1 STEVENS INST TECHNOL LIB,HOBOKEN,NJ 07030. GEOCENTERS INC,NEWTON CTR,MA 02159. RP LAREAU, RT (reprint author), USA,LABCOM,ELECTR TECHNOL & DEVICES LAB,SLCET,EJ,FT MONMOUTH,NJ 07703, USA. NR 10 TC 3 Z9 3 U1 0 U2 0 PU JOHN WILEY & SONS LTD PI W SUSSEX PA BAFFINS LANE CHICHESTER, W SUSSEX, ENGLAND PO19 1UD SN 0142-2421 J9 SURF INTERFACE ANAL JI Surf. Interface Anal. PD JAN PY 1991 VL 17 IS 1 BP 38 EP 42 DI 10.1002/sia.740170110 PG 5 WC Chemistry, Physical SC Chemistry GA EV059 UT WOS:A1991EV05900008 ER PT J AU BARTKY, IR AF BARTKY, IR TI THE MOST RELIABLE TIME - COMMENT SO TECHNOLOGY AND CULTURE LA English DT Note RP BARTKY, IR (reprint author), USA,LAB COMMAND,ADELPHI,MD 20783, USA. NR 1 TC 0 Z9 0 U1 0 U2 0 PU UNIV CHICAGO PRESS PI CHICAGO PA 5720 S WOODLAWN AVE, CHICAGO, IL 60637 SN 0040-165X J9 TECHNOL CULT JI Technol. Cult. PD JAN PY 1991 VL 32 IS 1 BP 183 EP 185 DI 10.2307/3106048 PG 3 WC History & Philosophy Of Science SC History & Philosophy of Science GA FN370 UT WOS:A1991FN37000044 ER PT J AU KEERATITHAKUL, D TEJAISAVADHARM, P SHANKS, GD WEBSTER, HK EDSTEIN, MD AF KEERATITHAKUL, D TEJAISAVADHARM, P SHANKS, GD WEBSTER, HK EDSTEIN, MD TI AN IMPROVED HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC METHOD FOR THE SIMULTANEOUS MEASUREMENT OF HALOFANTRINE AND DESBUTYLHALOFANTRINE IN HUMAN SERUM SO THERAPEUTIC DRUG MONITORING LA English DT Article DE HALOFANTRINE; DESBUTYLHALOFANTRINE; MALARIA; HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY ID METABOLITE; MALARIA AB A rapid, accurate, and sensitive high-performance liquid chromatographic (HPLC) method, with ultraviolet detection, for simultaneous measurement of halofantrine (HAL) and desbutylhalofantrine (BHAL) in human serum is described. Sample preparation involved protein precipitation, followed by a solid-phase clean-up and a liquid-liquid extraction. Chromatographic separation was carried out on an Ultrasphere C8 column (25 cm x 4.6 mm I.D., 5 mu-m particle size) using a mobile phase of acetonitrile: water, 75:25, (vol/vol), with 0.2% (w/vol) sodium dodecyl sulfate and 0.2% (vol/vol) glacial acetic acid. The serum sample volume used was 0.5 ml, with concentrations normalized to 1 ml. Retention times for BHAL, HAL, and the internal standard were 5.5, 8.3, and 11.5 min, respectively, with a total run time of 13.5 min. The average extraction recovery for HAL was 85.6% and 100.5% for BHAL. Inter- and intra-assay precisions of HAL and BHAL were less-than-or-equal-to 7.5%, with an accuracy of less-than-or-equal-to 10.8% over three concentrations (0.02, 0.5, 2.0-mu-g/ml). Detection limits of HAL and BHAL were 5 and 3 ng/ml, respectively. The new HPLC method resulted in cleaner chromatograms and a 1.7-fold faster run time than previous HPLC methods. Application of the method with clinical specimens was demonstrated. C1 ARMED FORCES RES INST MED SCI,DEPT MED,BANGKOK,THAILAND. ARMED FORCES RES INST MED SCI,DEPT IMMUNOL & BIOCHEM,BANGKOK,THAILAND. RI Shanks, George Dennis/F-4056-2014 OI Shanks, George Dennis/0000-0001-5763-8660 NR 8 TC 20 Z9 20 U1 0 U2 2 PU LIPPINCOTT-RAVEN PUBL PI PHILADELPHIA PA 227 EAST WASHINGTON SQ, PHILADELPHIA, PA 19106 SN 0163-4356 J9 THER DRUG MONIT JI Ther. Drug Monit. PD JAN PY 1991 VL 13 IS 1 BP 64 EP 68 DI 10.1097/00007691-199101000-00009 PG 5 WC Medical Laboratory Technology; Pharmacology & Pharmacy; Toxicology SC Medical Laboratory Technology; Pharmacology & Pharmacy; Toxicology GA EZ961 UT WOS:A1991EZ96100009 PM 2057994 ER PT J AU NASEEM, SM MEREISH, KA SOLOW, R HINES, HB AF NASEEM, SM MEREISH, KA SOLOW, R HINES, HB TI MICROCYSTIN-INDUCED ACTIVATION OF PROSTAGLANDIN SYNTHESIS AND PHOSPHOLIPID-METABOLISM IN RAT HEPATOCYTES SO TOXICOLOGY IN VITRO LA English DT Article ID ARACHIDONIC-ACID METABOLISM; T-2 TOXICOSIS; AERUGINOSA; TOXIN; CELLS; LR; DEXAMETHASONE; THROMBOXANE; PRESSURE; PEPTIDE AB The effects of microcystin-LR, a trichothecene, T-2 and saxitoxin on membrane lipid mediators of inflammatory processes were evaluated in cultured rat hepatocytes using [C-14]arachidonic acid. Microcystin-LR significantly stimulated the release of prostacyclin, measured as 6-keto PGF1-alpha, by 38%, and thromboxane B2 by 50%, in a concentration-dependent manner. The trichothecene toxin T-2 enhanced the release of prostaglandin F2-alpha by 24% and arachidonic acid by 29%; while saxitoxin did not affect the release prostaglandins or arachidonic acid. Incorporation of arachidonic acid into the lipid pool was reduced by 47% by 1-mu-M microcystin-LR. Changes in the distribution of radioactivity derived from [C-14]arachidonic acid within phospholipid classes indicated that prostaglandin formation induced by microcystin-LR was also due to the release of arachidonic acid from the phosphatidylinositol pool. No statistically significant effect of toxin was observed on the contribution of [C-14]arachidonic acid release by other classes of phospholipids or neutral lipids. These effects may be important in the mechanism of microcystin-LR-induced toxicity in the liver. RP NASEEM, SM (reprint author), USA,MED RES INST INFECT DIS,DIV PATHOPHYSIOL,FT DETRICK,FREDERICK,MD 21702, USA. NR 28 TC 4 Z9 4 U1 1 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0887-2333 J9 TOXICOL IN VITRO JI Toxicol. Vitro PY 1991 VL 5 IS 4 BP 341 EP 345 DI 10.1016/0887-2333(91)90011-2 PG 5 WC Toxicology SC Toxicology GA GB455 UT WOS:A1991GB45500010 PM 20732035 ER PT J AU WEINSTEIN, SA SCHMIDT, JJ BERNHEIMER, AW SMITH, LA AF WEINSTEIN, SA SCHMIDT, JJ BERNHEIMER, AW SMITH, LA TI CHARACTERIZATION AND AMINO-ACID-SEQUENCES OF 2 LETHAL PEPTIDES ISOLATED FROM VENOM OF WAGLERS PIT VIPER, TRIMERESURUS-WAGLERI SO TOXICON LA English DT Article ID CROTALUS-SCUTULATUS-SCUTULATUS; RATTLESNAKE VENOM; VIRIDIS-VIRIDIS; PROTEIN; TOXINS; SNAKE; PURIFICATION; COMPONENT; MYOTOXIN; SUBUNITS AB Two lethal toxins were isolated from Trimeresurus wagleri venom by fast protein liquid chromatography (molecular sieve) and high performance liquid chromatography (reverse phase). The toxins (termed peptide I and II) had mol. wt of 2504 and 2530, respectively, pIs of 9.6-9.9 and lacked phospholipase A, proteolytic, and hemolytic activity. Lethal peptide I had a murine i.p. LD50 of 0.369 mg/kg, while lethal II had a murine i.p. LD50 of 0.583 mg/kg. Peptide I retained full toxicity after autoclaving at 121-degrees-C for 40 min. The lethal activity was found to represent less than 1% of the total venom protein, which was only 62-65% of crude venom. The amino acid sequence of peptide I revealed a proline-rich (over 30% of total sequence) sequence unique among snake venom toxins. Lethal peptide II showed the same sequence except for a second tyrosine in the position of histidine (residue No. 10) in peptide I. The toxin lacked antigenic identity with a number of representative neurotoxins and myotoxins. The crude venom shared at least one antigen with Crotalus scutulatus scutulatus venom. This antigen was not Mojave toxin. The toxin appears symptomologically suggestive of a vasoactive peptide or neurotoxin. C1 USA,MED RES INST INFECT DIS,DEPT TOXINOL,DIV PATHOL,FREDERICK,MD 21701. NYU,DEPT MICROBIOL,NEW YORK,NY 10016. NR 33 TC 34 Z9 36 U1 1 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0041-0101 J9 TOXICON JI Toxicon PY 1991 VL 29 IS 2 BP 227 EP 236 DI 10.1016/0041-0101(91)90107-3 PG 10 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA EX659 UT WOS:A1991EX65900010 PM 2048140 ER PT J AU MIURA, GA ROBINSON, NA LAWRENCE, WB PACE, JG AF MIURA, GA ROBINSON, NA LAWRENCE, WB PACE, JG TI HEPATOTOXICITY OF MICROCYSTIN-LR IN FED AND FASTED RATS SO TOXICON LA English DT Article ID CYCLIC HEPTAPEPTIDE TOXINS; PEPTIDE HEPATOTOXIN; AERUGINOSA; TOXICITY; MICE; CYANOBACTERIA; HEPATOCYTES; INVITRO; INVIVO AB The LD50 (25 hr, i.p.) for microcystin-LR in fed rats (122-mu-g/kg) was significantly higher than that in fasted rats (72-mu-g/kg). At doses of 100, 150 and 200-mu-g of microcystin-LR per kg, the median times to death were 31.9, 18.2 and 11.2 hr for fed rats, and 1.8, 1.7 and 1.5 hr for fasted rats. A sublethal dose of microcystin (50-mu-g/kg) afforded protection to fasted, but not fed, rats against a subsequent lethal dose (200-mu-g/kg) challenge given 72 hr later. Biochemical and ultrastructural changes resulting from microcystin-LR (100-mu-g/kg, i.p.) were compared in fed and fasted rats 1 hr after injection. In both groups, liver weight and serum levels of sorbitol dehydrogenase and glucose significantly increased. Plasma membranes, isolated from livers of fed or fasted rats, exhibited similar toxin-induced changes in associated cytoskeletal elements. Liver mitochondria from toxin-treated, fasted rats exhibited complete inhibition of state 3 respiration, while those from toxin-treated, fed rats had ADP/O ratios and respiratory control indices comparable to control values. The primary event responsible for enhanced microcystin hepatotoxicity in the fasted state has not yet been identified. Depletion of glycogen stores and a decreased respiratory capacity may, however, play significant roles in this degenerative process. C1 USA,MED RES INST INFECT DIS,DIV PATHOL,FREDERICK,MD 21702. RP MIURA, GA (reprint author), USA,MED RES INST INFECT DIS,DIV PATHOPHYSIOL,FT DETRICK,FREDERICK,MD 21702, USA. NR 32 TC 31 Z9 41 U1 0 U2 11 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0041-0101 J9 TOXICON JI Toxicon PY 1991 VL 29 IS 3 BP 337 EP 346 DI 10.1016/0041-0101(91)90287-2 PG 10 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA FD983 UT WOS:A1991FD98300007 PM 2048148 ER PT J AU MIDDLEBROOK, JL AF MIDDLEBROOK, JL TI PREPARATION AND CHARACTERIZATION OF MONOCLONAL-ANTIBODIES AGAINST PSEUDEXIN SO TOXICON LA English DT Article ID BETA-BUNGAROTOXIN; SNAKE; PHOSPHOLIPASE-A2; NEUROTOXINS; VENOMS AB Fifteen hybridoma cell lines secreting monoclonal antibodies against pseudexin were developed. The cell lines were grown as ascites tumors and the resulting antibodies were purified by Protein A affinity-chromatography. Several of the antibodies exhibited extensive ELISA cross-reactions with different phospholipase A2 toxins from various snake venoms, while other of the antibodies reacted only with the pseudexins. Three of the antibodies neutralized pseudexin A and B, but none of the 10 other phospholipase A2 toxins tested. These same three antibodies inhibited the enzymatic activity of pseudexin A and B and also that of notexin. After each antibody was labeled with biotin, competition experiments were carried out to determine the binding relationships among the antibodies and the pseudexins. Competitions were frequently observed, with a low of zero to a high of eight out of the 14 possibilities. Competition experiments were also carried out with biotin-labeled rabbit IgG against the pseudexins. Some of the monoclonal antibodies had no effect on rabbit IgG binding to pseudexin, while others blocked up to 50% of the binding. RP MIDDLEBROOK, JL (reprint author), USA,MED RES INST INFECT DIS,DEPT TOXICOL,DIV SMALL ANIM MED & SURG,FREDERICK,MD 21701, USA. NR 14 TC 9 Z9 9 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0041-0101 J9 TOXICON JI Toxicon PY 1991 VL 29 IS 3 BP 359 EP 370 DI 10.1016/0041-0101(91)90289-4 PG 12 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA FD983 UT WOS:A1991FD98300009 PM 2048149 ER PT J AU WEINSTEIN, SA CHISZAR, D BELL, RC SMITH, LA AF WEINSTEIN, SA CHISZAR, D BELL, RC SMITH, LA TI LETHAL POTENCY AND FRACTIONATION OF DUVERNOY SECRETION FROM THE BROWN TREE SNAKE, BOIGA-IRREGULARIS SO TOXICON LA English DT Article ID GLAND SECRETION; VENOM AB The liquid secretion contained only 15% protein and had relatively low proteolytic activity. The reconstituted crude secretion had a murine i.p. LD50 of 10.33 mg/kg and was not hemorrhagic in doses up to 200-mu-g. Fast Protein Liquid Chromatographic (FPLC) cation exchange analysis of reconstituted crude secretion resulted in resolution of 16 peaks. Lethal activity was identified in three peaks. The major lethal fraction was 12.5% of the secretion protein and had a murine i.p. LD50 of 7.3 mg/kg. A pooled fraction containing two lethal peaks which comprised 9.4% of secretion protein had moderate proteolytic activity and produced myoglobinuria in mice. The fraction had an approximate murine i.p. LD50 of 3.7 mg/kg. Microscopic examination of muscle tissue from mice succumbing to this fraction revealed multifocal myofiber degeneration and necrosis. SDS-PAGE indicated that the major lethal fraction contained three proteins with mol. wts of 12,500, 18,000 and 52,000 and the myotoxic fraction contained two proteins with mol. wts of 14,500 and 17,000. While B. irregularis Duvernoy's secretion has a low lethal index, it does contain a myotoxic fraction with moderate lethal potency. These observations and recent data describing clinical envenomation of several infant patients suggest that large specimens may pose a hazard to infants and small children. C1 USA, MED RES INST INFECT DIS, DEPT TOXINOL, FT DETRICK, FREDERICK, MD 21702 USA. USA, MED RES INST INFECT DIS, DEPT COMPARAT PATHOL, DIV PATHOL, FREDERICK, MD 21702 USA. UNIV COLORADO, DEPT PSYCHOL, BOULDER, CO 80309 USA. NR 30 TC 26 Z9 27 U1 1 U2 4 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0041-0101 J9 TOXICON JI Toxicon PY 1991 VL 29 IS 4-5 BP 401 EP 407 DI 10.1016/0041-0101(91)90014-I PG 7 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA FG047 UT WOS:A1991FG04700002 PM 1862518 ER PT J AU STILES, BG AF STILES, BG TI A NONRADIOACTIVE RECEPTOR ASSAY FOR SNAKE-VENOM POSTSYNAPTIC NEUROTOXINS SO TOXICON LA English DT Article ID HUMAN ACETYLCHOLINE-RECEPTOR; SODIUM DODECYL-SULFATE; ALPHA-SUBUNIT; TORPEDO-CALIFORNICA; MYASTHENIA-GRAVIS; BUNGAROTOXIN BINDING; PROTEIN BLOTS; ANTIBODIES; LOCALIZATION; RESTORATION AB A non-radioactive assay was developed for detecting the binding of postsynaptic neurotoxins to acetylcholine receptor (AchR) from Torpedo californica. Enzyme linked immunosorbent assay (ELISA) wells coated with long or short chain neurotoxins specifically bound to purified AchR while crotamine or two different cardiotoxins did not. Bound receptor was detected by antibody against AchR. Specificity was determined by dose-response experiments and competition studies using carbamylcholine chloride, acetylcholine chloride, or Naja naja atra cobrotoxin mixed with receptor. RP STILES, BG (reprint author), USA,MED RES INST INFECT DIS,DEPT TOXINOL,DIV PATHOPHYSIOL,FREDERICK,MD 21702, USA. NR 28 TC 12 Z9 12 U1 1 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0041-0101 J9 TOXICON JI Toxicon PY 1991 VL 29 IS 4-5 BP 503 EP 510 DI 10.1016/0041-0101(91)90024-L PG 8 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA FG047 UT WOS:A1991FG04700012 PM 1862522 ER PT J AU CROSLAND, RD AF CROSLAND, RD TI EFFECT OF DRUGS ON THE LETHALITY IN MICE OF THE VENOMS AND NEUROTOXINS FROM SUNDRY SNAKES SO TOXICON LA English DT Article ID BETA-BUNGAROTOXIN; PHARMACOLOGICAL CHARACTERIZATION; PHOSPHOLIPASE-A2; INHIBITION; CALCIUM; BRAIN; BLOCKERS; INVITRO; BINDING AB I investigated the efficacy of 10 drugs with respect to reducing the lethality in mice of the following venoms and their respective neurotoxins: Bungarus caeruleus venom; Bungarus multicinctus venom, alpha-bungarotoxin, beta-bungarotoxin; Crotalus durissus terrificus venom, crotoxin; Notechis scutatus scutatus venom; Oxyuranus scutellatus venom, taipoxin. The drugs diltiazem, nicergoline, primaquine, verapamil and vesamicol protected mice from the lethality of B. caeruleus venom, B. multicinctus venom, and/or beta-bungarotoxin. Dexamethasone provided protection from B. multicinctus venom, beta-bungarotoxin, crotoxin, O. scutellatus venom and taipoxin. Protective activity resided in amphiphilic drugs and correlated with the charge on the drug at physiological pH. Protection from lethality was maximal when the drugs were administered immediately after injection of the venom or toxin. Nifedipine, piracetam and reserpine provided no protection from any of the venoms or toxins tested. RP CROSLAND, RD (reprint author), USA,MED RES INST INFECT DIS,DIV PATHOPHYSIOL,FREDERICK,MD 21702, USA. NR 32 TC 9 Z9 9 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0041-0101 J9 TOXICON JI Toxicon PY 1991 VL 29 IS 6 BP 613 EP 631 DI 10.1016/0041-0101(91)90055-V PG 19 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA FT422 UT WOS:A1991FT42200006 PM 1926164 ER PT J AU HOLMES, MJ LEWIS, RJ POLI, MA GILLESPIE, NC AF HOLMES, MJ LEWIS, RJ POLI, MA GILLESPIE, NC TI STRAIN DEPENDENT PRODUCTION OF CIGUATOXIN PRECURSORS (GAMBIERTOXINS) BY GAMBIERDISCUS-TOXICUS (DINOPHYCEAE) IN CULTURE SO TOXICON LA English DT Article ID GUINEA-PIG ATRIA; SCOMBEROMORUS-COMMERSONI; SPANISH MACKEREL; VAS-DEFERENS; DINOFLAGELLATE; CIGUATERA; MODE; BREVETOXINS; MAITOTOXIN; CHANNEL AB Thirteen strains of Gambierdiscus toxicus isolated from Queensland (Australia), Hawaii, French Polynesia and the Virgin Islands were mass cultured and extracted for ciguatoxin. A biodetrital sample containing wild G. toxicus collected from the Republic of Kiribati was also extracted for ciguatoxin. Ciguatoxin, as characterized from moray eels, was not detected in any of the strains examined. Two Queensland strains and the wild G. toxicus produced putative ciguatoxin precursors named gambiertoxins. These gambiertoxins were less polar than ciguatoxin but produced bioassay signs in mice and in-vitro responses in isolated guinea pig atria and vas deferens which were similar (but not identical) to those produced by ciguatoxin. The gambiertoxins from cultured cells were also shown to competitively inhibit the binding of [H-3]brevetoxin-3 to rat brain membranes in a dose-dependent manner. The gambiertoxins were more potent than ciguatoxin (on a per mouse unit basis) at stimulating neural elements of guinea pig atria. The two culture strains produced similar amounts of gambiertoxins, even when grown in nutrient media made from different seawater containing different concentrations of nutrients. Changes in nutrient media did not induce the other strains of G. toxicus to produce gambiertoxins. The production of these ciguatoxin precursors appears to be limited to only certain genetic strains of G. toxicus, with the majority of strains not producing these toxins. We propose that ciguatera occurs when blooms of G. toxicus strains genetically capable of producing these ciguatoxin precursors enter the marine food chain. These toxins could then become oxidatively metabolized in fishes to the more polar ciguatoxin. Wild cells produced approximately 100-fold greater quantities of gambiertoxins per cell than did the two culture strains indicating that there is considerable potential for increased production of these ciguatoxin precursors from G. toxicus in culture. C1 USA,MED RES INST INFECT DIS,DIV PATHOPHYSIOL,FREDERICK,MD 21701. QUEENSLAND DEPT PRIMARY IND,BRIBIE ISL AQUACULTURE CTR,BRIBIE ISL,QLD 4507,AUSTRALIA. RP HOLMES, MJ (reprint author), QUEENSLAND DEPT PRIMARY IND,SO FISHERIES CTR,POB 76,DECEPTION BAY,QLD 4508,AUSTRALIA. RI Lewis, Richard/E-8674-2013 OI Lewis, Richard/0000-0003-3470-923X NR 39 TC 81 Z9 89 U1 4 U2 10 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0041-0101 J9 TOXICON JI Toxicon PY 1991 VL 29 IS 6 BP 761 EP 775 DI 10.1016/0041-0101(91)90068-3 PG 15 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA FT422 UT WOS:A1991FT42200019 PM 1926177 ER PT J AU ROBINSON, CP FRANZ, DR BONDURA, ME AF ROBINSON, CP FRANZ, DR BONDURA, ME TI EFFECTS OF LYNGBYATOXIN A FROM THE BLUE-GREEN-ALGA LYNGBYA-MAJUSCULA ON RABBIT AORTA CONTRACTIONS SO TOXICON LA English DT Article ID PROTEIN-KINASE-C; VASCULAR SMOOTH-MUSCLE; MOUSE SKIN CARCINOGENESIS; ESTER-INDUCED CONTRACTION; PHORBOL-ESTER; RAT AORTA; SIGNAL TRANSDUCTION; CALCIUM DEPENDENCE; PLASMA-MEMBRANE; TUMOR PROMOTERS AB The contractile effects of the tumor promoter and protein kinase C activator, lyngbyatoxin A, were studied in rabbit aorta rings. Contractions to 1-mu-M lyngbyatoxin A developed slowly, becoming maximal in approximately 3 hr. Contractions were not altered by 1-mu-M indomethacin, 1-mu-M nordihydroguaiaretic acid, or by endothelium removal, indicating that they did not involve contracting or relaxing substances from the epithelium. The contractions were also unaltered by calcium deletion from the medium and by 1-mu-M verapamil. Removal of adventitia did not alter contractions to lyngbyatoxin A, indicating that they did not involve release of norepinephrine or other neural vasoconstrictors. Previous contraction by norepinephrine in calcium-free medium containing a calcium-sequestering agent did not reduce subsequent lyngbyatoxin A contractions, indicating that they did not utilize the easily depleted intracellular calcium pool utilized by norepinephrine. Partial contraction with lyngbyatoxin A did not prevent contraction of the rings to norepinephrine. Contractions to lyngbyatoxin A in calcium-free medium did not differ from those obtained in calcium-free medium with 80 mM potassium chloride, indicating the contractions involved pharmacomechanical coupling. Contractions to both 1-mu-M lyngbyatoxin A and to 3-mu-M norepinephrine were depressed 18 hr after > 2 hr exposure to 1-mu-M lyngbyatoxin A (44 and 27%, respectively). Thus, lyngbyatoxin A contracts the rabbit aorta by an extracellular and intracellular calcium-, endothelium- and neuron-independent mechanism similar to the protein kinase C activating phorbol esters. C1 USA,MED RES INST INFECT DIS,DIV PATHOPHYSIOL,FREDERICK,MD 21702. RP ROBINSON, CP (reprint author), UNIV OKLAHOMA,HLTH SCI CTR,COLL PHARM,OKLAHOMA CITY,OK 73190, USA. NR 42 TC 3 Z9 4 U1 1 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0041-0101 J9 TOXICON JI Toxicon PY 1991 VL 29 IS 8 BP 1009 EP 1017 DI 10.1016/0041-0101(91)90083-4 PG 9 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA GD367 UT WOS:A1991GD36700009 PM 1949059 ER PT J AU LEWIS, RJ SELLIN, M POLI, MA NORTON, RS MACLEOD, JK SHEIL, MM AF LEWIS, RJ SELLIN, M POLI, MA NORTON, RS MACLEOD, JK SHEIL, MM TI PURIFICATION AND CHARACTERIZATION OF CIGUATOXINS FROM MORAY EEL (LYCODONTIS-JAVANICUS, MURAENIDAE) SO TOXICON LA English DT Article ID GAMBIERDISCUS-TOXICUS; BREVETOXINS; CIGUATERA; CHANNEL; FISH AB Viscera (48.3 kg) from moray eels (Lycodontis javanicus) collected in a ciguatera endemic area were extracted and the ciguatoxins characterized. Three major ciguatoxins, CTX-1, CTX-2 and CTX-3, were isolated and purified to homogeneity on reverse phase high performance liquid chromatography. Several minor toxins were also detected. CTX-1 (490-mu-g) was comparable by both H-1 nuclear magnetic resonance (H-1 NMR) and mass spectroscopy (MH+ m/z = 1111) to ciguatoxin isolated previously from moray eels. CTX-2 (280-mu-g) and CTX-3 (100-mu-g) were less polar ciguatoxins not previously characterized. CTX-2 and CTX-3 differed from CTX-1 by 16 mass units, suggesting that they were less oxygenated analogues. H-1 NMR revealed that the hydroxyl at C54 in CTX-1 was absent in CTX-2 and CTX-3. An additional change in the chemistry of CTX-2 compared to CTX-1 and CTX-3 was also suggested on the basis of H-1 NMR, indicating that CTX-2 may arise from a different precursor to CTX-1. CTX-3 is likely to be an intermediate in the oxidation of a gambiertoxin (sodium channel toxins from Gambierdiscus toxicus) to CTX-1. The i.p. LD50 values for CTX-1, CTX-2 and CTX-3 were 0.25, 2.3 and 0.9-mu-g/kg, respectively. The signs induced in mice by the ciguatoxins were similar, except that CTX-2 and CTX-3 induced hind-limb paralysis that was absent with CTX-1. Each ciguatoxin was potent orally. CTX-1, CTX-2 and CTX-3 competitively inhibited the binding of [H-3] brevetoxin-3 to voltage-dependent sodium channels with relative potencies qualitatively (but not quantitatively) comparable to mouse lethality. This study reveals that the relatively small chemical differences between CTX-1, CTX-2 and CTX-3 give rise to significant structure-activity and pharmacokinetic differences. C1 USA,MED RES INST INFECT DIS,DIV PATHOPHYSIOL,FREDERICK,MD 21702. UNIV NEW S WALES,SCH BIOCHEM,KENSINGTON,NSW 2033,AUSTRALIA. AUSTRALIAN NATL UNIV,RES SCH CHEM,CANBERRA,ACT 2601,AUSTRALIA. RP LEWIS, RJ (reprint author), QUEENSLAND DEPT PRIMARY IND,SO FISHERIES RES CTR,DECEPTION BAY,QLD 4508,AUSTRALIA. RI Lewis, Richard/E-8674-2013; Sheil, Margaret/F-2949-2015 OI Lewis, Richard/0000-0003-3470-923X; NR 23 TC 181 Z9 189 U1 2 U2 12 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0041-0101 J9 TOXICON JI Toxicon PY 1991 VL 29 IS 9 BP 1115 EP 1127 DI 10.1016/0041-0101(91)90209-A PG 13 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA GJ400 UT WOS:A1991GJ40000006 PM 1665604 ER PT J AU STILES, BG SEXTON, FW WEINSTEIN, SA AF STILES, BG SEXTON, FW WEINSTEIN, SA TI ANTIBACTERIAL EFFECTS OF DIFFERENT SNAKE-VENOMS - PURIFICATION AND CHARACTERIZATION OF ANTIBACTERIAL PROTEINS FROM PSEUDECHIS-AUSTRALIS (AUSTRALIAN KING BROWN OR MULGA SNAKE) VENOM SO TOXICON LA English DT Article ID AEROMONAS-HYDROPHILA; DIARRHEA AB Venoms from 30 different snake species were tested in a disc diffusion assay for antibacterial effects against gram-positive and gram-negative bacteria. A number of venoms gave a zone of inhibition against both groups of bacteria, including Aeromonas hydrophila, an important pathogen of reptiles and amphibians. Two antibacterial components from the venom of an Australian elapid, Pseudechis australis (Australian king brown or mulga snake) were purified to homogeneity. The proteins, designated LAO1 and LAO2, had potent antibacterial properties associated with L-amino acid oxidase activity. Both had native and subunit mol. wts of 142,000 and 56,000, respectively. Antibacterial activity correlated with enzymatic activity and was eliminated with catalase. LAO1 and LAO2 had 244 and 113 units of L-amino acid oxidase activity/mg protein, respectively. Compared to tetracycline, a drug of choice for Aeromonas infections in humans, reptiles and amphibians, the in vitro antibacterial effects of LAO1 and LAO2 were respectively 70 and 17.5 times more effective (on a molar basis). RP STILES, BG (reprint author), USA,MED RES INST INFECT DIS,DEPT TOXINOL,DIV PATHOPHYSIOL,FREDERICK,MD 21702, USA. NR 26 TC 103 Z9 114 U1 0 U2 7 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0041-0101 J9 TOXICON JI Toxicon PY 1991 VL 29 IS 9 BP 1129 EP 1141 DI 10.1016/0041-0101(91)90210-I PG 13 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA GJ400 UT WOS:A1991GJ40000007 PM 1796476 ER PT J AU STILES, BG LIDGERDING, BC SEXTON, FW SHAWN, B AF STILES, BG LIDGERDING, BC SEXTON, FW SHAWN, B TI PRODUCTION AND CHARACTERIZATION OF MONOCLONAL-ANTIBODIES AGAINST NAJA-NAJA-ATRA COBRATOXIN SO TOXICON LA English DT Article; Proceedings Paper CT 3RD INTERNATIONAL SYMP ON NEUROTOXINS IN NEUROBIOLOGY CY MAR 16-20, 1991 CL PIRIAPOLIS, URUGUAY SP INT PROGRAM CHEM SCI, UPPSALA UNIV ID ALPHA-BUNGAROTOXIN-BINDING; ACETYLCHOLINE-RECEPTOR; SNAKE-VENOMS; EXTRACELLULAR PART; ERABUTOXIN-B; AMINO-ACID; NEUROTOXINS; LOCALIZATION; TOXIN; NEUTRALIZATION AB Twelve monoclonal antibodies against cobrotoxin from Naja naja atra venom were tested for cross-reactivity with eight different snake toxins, binding to linear epitopes, prevention of cobrotoxin binding to acetylcholine receptor (AchR) in vitro, and protection in mice concomitantly given a lethal dose of cobrotoxin. The antibodies were highly specific, as evidenced by little reactivity with other snake toxins. None of the monoclonal antibodies bound to reduced cobrotoxin or synthesized 8-mer regions spanning the whole molecule, thus suggesting the recognition of conformational epitopes. The in vitro binding of toxin to AchR was competitively inhibited (23-79%) with a 1.66:1 mole ratio of antibody:AchR. Preincubation of monoclonal antibody with toxin before adding AchR (3:1 mole ratio of AchR:antibody) inhibited the in vitro binding of toxin to AchR by 20-80%. Monoclonal antibodies added after the preincubation of toxin with AchR did not dissociate the toxin-AchR complex. An antibody:toxin mole ratio of 2.5:1, with 6-mu-g of cobrotoxin, delayed the time to death of mice 3.7-23.8-fold over control mice. The monoclonal antibodies that most effectively prevented in vitro binding of toxin to AchR also provided the longest delay in time to death in mice. C1 USA,MED RES INST INFECT DIS,DIV VIROL,FREDERICK,MD 21702. RP STILES, BG (reprint author), USA,MED RES INST INFECT DIS,DEPT TOXINOL,DIV PATHOPHYSIOL,FREDERICK,MD 21702, USA. NR 36 TC 10 Z9 10 U1 1 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0041-0101 J9 TOXICON JI Toxicon PY 1991 VL 29 IS 10 BP 1195 EP 1204 DI 10.1016/0041-0101(91)90192-T PG 10 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA GP119 UT WOS:A1991GP11900003 PM 1724806 ER PT J AU WEINSTEIN, SA SCHMIDT, JJ SMITH, LA AF WEINSTEIN, SA SCHMIDT, JJ SMITH, LA TI LETHAL TOXINS AND CROSS-NEUTRALIZATION OF VENOMS FROM THE AFRICAN WATER COBRAS, BOULENGERINA-ANNULATA-ANNULATA AND BOULENGERINA-CHRISTYI SO TOXICON LA English DT Article ID SNAKE; ACID; PURIFICATION AB Venoms of the water cobras, Boulengerina, were assayed for lethality, proteolytic activity and protein content. Boulengerina annulata annulata and B. christyi venoms averaged 89% protein and lacked proteolytic activity. The murine i.p. LD50 Of B. a. annulata and B. christyi venoms were 0. 143 and 0. 1 20 mg/kg, respectively. Polyvalent antivenom produced by the South African Institute of Medical Research neutralized 575 and 200 LD50 of B. a. annulata and B. christyi venoms/ml antivenom, respectively. Cation exchange chromatography resolved four lethal peaks from B. a. annulata venom and six lethal peaks from B. christyi venom. The major lethal peaks (about 12% of total venom protein) were purified further with molecular sieve chromatography and were characterized as 61 (B. a. annulata toxin) and 62 (B. christyi toxin) residue polypeptides with four half-cystines. Elucidation of the complete amino acid sequences indicated that these toxins belonged to the short-chain class of postsynaptic neurotoxins. Short-chain neurotoxins 1 from B. a. annulata and B. christyi had murine i.p. LD50 of 0.052 and 0.083 mg/kg, respectively, and showed over 80% homology with N. nigricollis alpha toxin. Reverse-phase analysis of another peak present in both venoms resolved a toxin that had an N-terminus identical to B. christyi short-chain neurotoxin 1. These fractions also contained toxins readily separable from the short-chain isotoxin by preparative reverse-phase chromatography. Amino acid sequencing of the first 28 residues indicated that both toxins were long-chain neurotoxins with identical N-termini. The LD50 of long-chain neurotoxins 2 from B. a. annulata and B. christyi venoms were 0.086 and 0.090 mg/kg, respectively. The venoms of these little-known elapids have the lowest LD50 of any African proteroglyph studied thus far and have high concentrations of potent postsynaptic neurotoxins. C1 USA,MED RES INST INFECT DIS,DIV PATHOPHYSIOL,FT DETRICK,FREDERICK,MD 21702. NR 18 TC 4 Z9 7 U1 0 U2 2 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0041-0101 J9 TOXICON JI Toxicon PY 1991 VL 29 IS 11 BP 1315 EP 1327 DI 10.1016/0041-0101(91)90118-B PG 13 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA GV860 UT WOS:A1991GV86000003 PM 1814007 ER PT J AU MIDDLEBROOK, JL AF MIDDLEBROOK, JL TI CROSS-NEUTRALIZATIONS OF PHOSPHOLIPASE-A2 NEUROTOXINS FROM SNAKE-VENOMS SO TOXICON LA English DT Article ID NOTECHIS-SCUTATUS-SCUTATUS; BELLIED BLACK SNAKE; PSEUDECHIS-PORPHYRIACUS; PRESYNAPTIC NEUROTOXIN; PURIFICATION; TOXINS AB Rabbit antisera were produced against several purified phospholipase A2 neurotoxins from snake venoms. The neutralizing and cross-neutralizing capacities of these antisera were evaluated using mice. In all except one case, homologous antisera neutralized the lethal effects of the neurotoxins. In several instances, antisera that exhibited strong ELISA cross-reactivity (MIDDLEBROOK and KAISER, Toxicon, 27, 965-977, 1989) were also capable of cross-neutralizations. Homologous antisera neutralized elapid neurotoxins much more effectively than did heterologous antisera. With the crotalid neurotoxins, homologous and heterologous antisera had similar neutralization potentials. These observations further define the immunological relatedness of the phospholipase A2 neurotoxins and suggest that common neutralizing epitopes exist within subgroups of these toxins. RP MIDDLEBROOK, JL (reprint author), USA,MED RES INST INFECT DIS,DEPT TOXINOL,DIV PATHOPHYSIOL,FREDERICK,MD 21702, USA. NR 15 TC 7 Z9 7 U1 0 U2 0 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0041-0101 J9 TOXICON JI Toxicon PY 1991 VL 29 IS 12 BP 1481 EP 1487 DI 10.1016/0041-0101(91)90004-B PG 7 WC Pharmacology & Pharmacy; Toxicology SC Pharmacology & Pharmacy; Toxicology GA GY762 UT WOS:A1991GY76200005 PM 1801325 ER PT J AU WILLET, GP MILHOUS, WK GERENA, L ODUOLA, AMJ AF WILLET, GP MILHOUS, WK GERENA, L ODUOLA, AMJ TI MIXED POPULATION-DYNAMICS IN HUMAN MALARIA PARASITE CULTURES SO TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE LA English DT Note ID PLASMODIUM-FALCIPARUM; INVITRO C1 WALTER REED ARMY MED CTR,DIV EXPTL THERAPEUT,WASHINGTON,DC 20307. NR 5 TC 17 Z9 17 U1 0 U2 2 PU ROYAL SOC TROPICAL MEDICINE PI LONDON PA MANSON HOUSE 26 PORTLAND PLACE, LONDON, ENGLAND W1N 4EY SN 0035-9203 J9 T ROY SOC TROP MED H JI Trans. Roy. Soc. Trop. Med. Hyg. PD JAN-FEB PY 1991 VL 85 IS 1 BP 33 EP 34 DI 10.1016/0035-9203(91)90142-L PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA FB377 UT WOS:A1991FB37700008 PM 2068751 ER PT J AU GREEN, CA RATTANARITHIKUL, R PONGPARIT, S SAWADWONGPORN, P BAIMAI, V AF GREEN, CA RATTANARITHIKUL, R PONGPARIT, S SAWADWONGPORN, P BAIMAI, V TI A NEWLY-RECOGNIZED VECTOR OF HUMAN MALARIAL PARASITES IN THE ORIENTAL REGION, ANOPHELES (CELLIA) PSEUDOWILLMORI (THEOBALD, 1910) SO TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE LA English DT Note ID PLASMODIUM-VIVAX; CULICIDAE; DIPTERA C1 ARMED FORCES RES INST MED SCI,USA COMPONENT,DEPT ENTOMOL,BANGKOK 10400,THAILAND. RP GREEN, CA (reprint author), MAHIDOL UNIV,FAC SCI,DEPT BIOL,RAMA VI RD,BANGKOK 10400,THAILAND. NR 8 TC 26 Z9 32 U1 0 U2 0 PU ROYAL SOC TROPICAL MEDICINE PI LONDON PA MANSON HOUSE 26 PORTLAND PLACE, LONDON, ENGLAND W1N 4EY SN 0035-9203 J9 T ROY SOC TROP MED H JI Trans. Roy. Soc. Trop. Med. Hyg. PD JAN-FEB PY 1991 VL 85 IS 1 BP 35 EP 36 DI 10.1016/0035-9203(91)90143-M PG 2 WC Public, Environmental & Occupational Health; Tropical Medicine SC Public, Environmental & Occupational Health; Tropical Medicine GA FB377 UT WOS:A1991FB37700009 PM 2068752 ER PT J AU ILBACK, NG CRAWFORD, DJ NEUFELD, HA FRIMAN, G AF ILBACK, NG CRAWFORD, DJ NEUFELD, HA FRIMAN, G TI DOES EXERCISE STRESS ALTER SUSCEPTIBILITY TO BACTERIAL-INFECTIONS SO UPSALA JOURNAL OF MEDICAL SCIENCES LA English DT Article ID SKELETAL-MUSCLE; MYOCARDITIS; MICE; METABOLISM; PROTEIN; RATS AB Swimming was used for evaluating alterations in performance capacity and as a means for studying the influence of exercise stress on susceptibility to Streptococcus pneumoniae and Francisella tularensis infections in two strains of rats, i.e. Fisher-Dunning (FD) and Sprague-Dawley (SD). The performance capacity was reduced by both diseases and was correlated to the dose of the given micro-organism. FD rats, however, were more susceptible to the infection and showed a greater deterioration than SD rats. The effects of exercise stress on disease lethality varied with the time that it was performed. Strenuous exercise immediately before infection drastically reduced susceptibility to either of the bacteria, while a similar bout of exercise performed after infection increased disease-related mortality in both diseases. C1 USA,MED RES INST INFECT DIS,FREDERICK,MD 21701. UNIV UPPSALA,DEPT INFECT DIS,S-75105 UPPSALA,SWEDEN. RP ILBACK, NG (reprint author), NATL FOOD ADM TOXICOL LAB,TOXICOL LAB,POB 622,S-75126 UPPSALA,SWEDEN. NR 24 TC 15 Z9 15 U1 0 U2 0 PU SCANDINAVIAN UNIVERSITY PRESS PI OSLO PA PO BOX 2959 TOYEN, JOURNAL DIVISION CUSTOMER SERVICE, N-0608 OSLO, NORWAY SN 0300-9734 J9 UPSALA J MED SCI JI Ups. J. Med. Sci. PY 1991 VL 96 IS 1 BP 63 EP 68 PG 6 WC Medicine, General & Internal SC General & Internal Medicine GA FU100 UT WOS:A1991FU10000006 PM 1897063 ER PT J AU MORRILL, JC CARPENTER, L TAYLOR, D RAMSBURG, HH QUANCE, J PETERS, CJ AF MORRILL, JC CARPENTER, L TAYLOR, D RAMSBURG, HH QUANCE, J PETERS, CJ TI FURTHER EVALUATION OF A MUTAGEN-ATTENUATED RIFT-VALLEY FEVER VACCINE IN SHEEP SO VACCINE LA English DT Article DE RIFT VALLEY FEVER; VACCINE; ATTENUATED; SHEEP; MUTAGEN ID VIRUS; IMMUNOGENICITY AB A previous study demonstrated that a mutagen-attenuated Rift Valley fever virus (RVFV) vaccine, RVF MP-12, was immunogenic and non-abortogenic when ewes, 90-110 days pregnant, were inoculated with 5 X 10(5) plaque-forming units (p.f.u.) of the virus strain. The ewes delivered live, healthy lambs that had no neutralizing antibody to RVFV until after they had ingested colostrum. To assess further the safety and protective capability of this candidate vaccine, six pregnant ewes were inoculated with 5 X 10(3) p.f.u. of RVF MP-12 and challenged with 5 X 10(5) p.f.u. of virulent ZH-501 strain of RVFV 30 days later. No viraemia was detected after vaccination or challenge and all six ewes delivered live, healthy lambs. Those lambs tested before their nursing did not have neutralizing antibody to RVFV but quickly acquired antibody titres of 1:320 to greater-than-or-equal-to 1:10 240 after ingesting colostrum. To test the safety of the RVF MP-12 immunogen in neonates, lambs less-than-or-equal-to 7 days old, born to unvaccinated ewes, were inoculated with 55 X 10(5) p.f.u. of RVF MP-12. With the exception of brief pyrexia in 18 of 26 lambs, and a transient low-titred viraemia in 16 of 26 lambs after inoculation, no untoward effects were observed. Serum-neutralizing antibody to RVFV was detected 5-7 days after inoculation. Lambs vaccinated with either 5 X 10(5) or 5 X 10(3) p.f.u. of RVF MP-12 were protected against virulent RVFV challenge at 14 days postvaccination. RP MORRILL, JC (reprint author), USA,MED RES INST INFECT DIS,FREDERICK,MD 21701, USA. NR 20 TC 67 Z9 68 U1 0 U2 3 PU BUTTERWORTH-HEINEMANN LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB SN 0264-410X J9 VACCINE JI Vaccine PD JAN PY 1991 VL 9 IS 1 BP 35 EP 41 DI 10.1016/0264-410X(91)90314-V PG 7 WC Immunology; Medicine, Research & Experimental SC Immunology; Research & Experimental Medicine GA EQ328 UT WOS:A1991EQ32800008 PM 2008798 ER PT J AU DEUBEL, V BORDIER, M MEGRET, F GENTRY, MK SCHLESINGER, JJ GIRARD, M AF DEUBEL, V BORDIER, M MEGRET, F GENTRY, MK SCHLESINGER, JJ GIRARD, M TI PROCESSING, SECRETION, AND IMMUNOREACTIVITY OF CARBOXY TERMINALLY TRUNCATED DENGUE-2 VIRUS ENVELOPE PROTEINS EXPRESSED IN INSECT CELLS BY RECOMBINANT BACULOVIRUSES SO VIROLOGY LA English DT Note ID STRUCTURAL PROTEINS; MONOCLONAL-ANTIBODIES; INFECTED VERO; TYPE-2 VIRUS; GLYCOPROTEINS; ENCEPHALITIS; VECTORS; IMMUNOFLUORESCENCE; DETERMINANTS; NUCLEOTIDE C1 INST PASTEUR,VIROL MOLEC LAB,F-75724 PARIS 15,FRANCE. ROCHESTER GEN HOSP,ROCHESTER,NY 14621. UNIV ROCHESTER,SCH MED & DENT,ROCHESTER,NY 14642. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. RP DEUBEL, V (reprint author), INST PASTEUR,ARBOVIRUS LAB,25 RUE DR ROUX,F-75724 PARIS 15,FRANCE. NR 23 TC 32 Z9 34 U1 0 U2 0 PU ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS PI SAN DIEGO PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 SN 0042-6822 J9 VIROLOGY JI Virology PD JAN PY 1991 VL 180 IS 1 BP 442 EP 447 DI 10.1016/0042-6822(91)90055-G PG 6 WC Virology SC Virology GA EP908 UT WOS:A1991EP90800054 PM 1984665 ER PT J AU BILLOCK, VA AF BILLOCK, VA TI THE RELATIONSHIP BETWEEN SIMPLE AND DOUBLE OPPONENT CELLS SO VISION RESEARCH LA English DT Article DE GANGLION CELL; DOUBLE OPPONENT CELL; COLOR OPPONENCY; STRIATE CORTEX; SIMPLE OPPONENT CELL; COLOR CONTRAST; COLOR CONSTANCY; TYPE-I CELL; TYPE-II CELL; TYPE-III CELL ID MONKEY STRIATE CORTEX; COLOR-VISION MECHANISMS; RETINAL GANGLION-CELLS; RECEPTIVE-FIELDS; LAMINAR SEGREGATION; VISUAL-CORTEX; ORGANIZATION; PHYSIOLOGY; RESPONSES; MACAQUES AB Little is known about the formation of double opponent cells (DOCs) from geniculate afferents. Three LGN cell types have been considered as DOC precursors. No simple wiring scheme based on these cell types is consistent with the available evidence. The color and luminance multiplexed signal of P-beta ganglion cells (Type I receptive fields) contains the information necessary to construct DOCs, provided that filtering operations can separate the two signals. Electrophysiological and anatomical evidence is consistent with Type I cells being filtered prior to the formation of DOCs. Cortical Type II and Type III cells can also be created by filtering. RP BILLOCK, VA (reprint author), USA,UNIVERSAL ENERGY SYST INC,AEROMED RES LAB,FT RUCKER,AL 36362, USA. FU NEI NIH HHS [EY04948] NR 51 TC 21 Z9 21 U1 0 U2 3 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0042-6989 J9 VISION RES JI Vision Res. PY 1991 VL 31 IS 1 BP 33 EP 42 DI 10.1016/0042-6989(91)90070-L PG 10 WC Neurosciences; Ophthalmology SC Neurosciences & Neurology; Ophthalmology GA EU478 UT WOS:A1991EU47800003 PM 2006551 ER PT J AU BURROWS, WD SCHMIDT, MO CARNEVALE, RM SCHAUB, SA AF BURROWS, WD SCHMIDT, MO CARNEVALE, RM SCHAUB, SA TI NONPOTABLE REUSE - DEVELOPMENT OF HEALTH CRITERIA AND TECHNOLOGIES FOR SHOWER WATER RECYCLE SO WATER SCIENCE AND TECHNOLOGY LA English DT Article; Proceedings Paper CT INTERNATIONAL SYMP ON WASTEWATER RECLAMATION AND REUSE CY SEP 24-26, 1991 CL COSTA BRAVA, SPAIN DE SHOWER WATER; RECYCLE; HEALTH CRITERIA; PATHOGENS; CONTAMINATION AB The U.S. Army is evaluating recycle of field shower water as a conservation practice in arid regions and is seeking to define appropriate technologies and health criteria. Shower wastewaters at a military installation have been characterized in terms of physical, chemical and microbiological parameters. Two treatment technologies have been investigated. Microfiltration cartridges with a nominal pore size of 0.2-mu-m achieved consistent removals of 75 +/- 15% of total organic carbon (TOC) and better than 99% of turbidity from synthetic shower water containing 50 to 100 mg/L of TOC as soap. An alternative treatment technology utilized powdered activated carbon and coagulation/flocculation/sedimentation followed by diatomaceous earth filtration. A TOC reduction of 70 +/- 15% was achieved in three separate studies, although at a cost of 1 g/L or more of powdered activated carbon. Revised quality criteria for recycled shower water have been developed with guidance from the National Research Council. Parameters which can practically be measured in the field are primarily associated with microbiological safety. Therefore, the safety of recycled shower water with respect to chemical contamination must depend on design considerations. RP BURROWS, WD (reprint author), USA,BIOMED RES & DEV LAB,FT DETRICK,FREDERICK,MD 21702, USA. NR 14 TC 20 Z9 20 U1 1 U2 8 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0273-1223 J9 WATER SCI TECHNOL JI Water Sci. Technol. PY 1991 VL 24 IS 9 BP 81 EP 88 PG 8 WC Engineering, Environmental; Environmental Sciences; Water Resources SC Engineering; Environmental Sciences & Ecology; Water Resources GA GG191 UT WOS:A1991GG19100009 ER PT J AU CROWNOVER, RL EVERITT, HO DELUCIA, FC SKATRUD, DD AF CROWNOVER, RL EVERITT, HO DELUCIA, FC SKATRUD, DD TI FREQUENCY STABILITY AND REPRODUCIBILITY OF OPTICALLY PUMPED FAR-INFRARED LASERS SO APPLIED PHYSICS LETTERS LA English DT Article ID FIR LASER AB Direct measurements of the gain profile of optically pumped far-infrared lasers show that large shifts in the laser frequency can be caused by the absorption from thermal molecules on the laser transition. The absorption shifting greatly exacerbates pump frequency deviations, resulting in an extreme sensitivity to pump offsets and drifts. This pressure-dependent shifting mechanism is not present in transversely pumped lasers, which explains their superior frequency reproductibility compared to longitudinally pumped lasers, and reconciles two apparently conflicting results regarding laser stability. C1 USA,RES OFF,RES TRIANGLE PK,NC 27709. RP CROWNOVER, RL (reprint author), DUKE UNIV,SCH MED,DEPT PHYS,DURHAM,NC 27706, USA. RI Everitt, Henry/L-7118-2013 OI Everitt, Henry/0000-0002-8141-3768 NR 11 TC 4 Z9 4 U1 0 U2 1 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0003-6951 J9 APPL PHYS LETT JI Appl. Phys. Lett. PD DEC 31 PY 1990 VL 57 IS 27 BP 2882 EP 2884 DI 10.1063/1.103765 PG 3 WC Physics, Applied SC Physics GA EQ504 UT WOS:A1990EQ50400004 ER PT J AU RUEGG, CL JAFFE, RI KOSTER, B SADOFF, JC ZOLLINGER, WD LOWELL, GH STRAND, M AF RUEGG, CL JAFFE, RI KOSTER, B SADOFF, JC ZOLLINGER, WD LOWELL, GH STRAND, M TI PREPARATION OF PROTEOSOME-BASED VACCINES CORRELATION OF IMMUNOGENICITY WITH PHYSICAL CHARACTERISTICS SO JOURNAL OF IMMUNOLOGICAL METHODS LA English DT Article DE VACCINE; ANTIGEN PRESENTATION; PEPTIDE-PROTEOSOME COMPLEXES; IMMUNOGENICITY; MALARIA; SYNTHETIC PEPTIDE ID PLASMODIUM-FALCIPARUM SPOROZOITES; MONOCLONAL-ANTIBODIES; MEMBRANE-PROTEINS; SUBUNIT VACCINES; MALARIA VACCINE; PEPTIDE; SAFETY; POLYSACCHARIDE; ENHANCEMENT; DENSITY AB In order to facilitate the use of proteosome-based vaccines, we have identified and analyzed the parameters that affect their immunogenicity. As a model system we used synthetic peptides (LCF6) containing sequences from the immunodominant (NANP)n tandem repeat region of the P. falciparum circumsporozoite protein, hydrophobically complexed to multimeric protein preparations (proteosomes) of meningococcal outer membrane proteins (OMP), since we have previously shown that high levels of anti-(NANP)n IgG can be elicited in mice by use of this novel adjuvant system (Lowell et al., 1988a). We have now examined these preparations by velocity sedimentation and measured their ability to elicit an IgG response in mice. Velocity sedimentation of freshly mixed OMP and LCF6, without dialysis, produced a limited number of small complexes, whereas dialysis of the mixture for 4 d yielded heterogeneously sized complexes that became more homogeneous when the dialysis was carried out for 7 or 10 days. The most homogeneous of these peptide-proteosome complexes (those dialyzed for 10 days) induced substantial levels of anti-(NANP)n IgG in mice, and shorter periods of dialysis resulted in vaccines that induced proportionately lower titers. Analysis of a series of preparations with varying LCF6:OMP ratios (w/w) showed that the degree of peptide substitution of the proteosomes was inversely proportional to the rate of sedimentation of the complexes and that there exists an optimal degree of lipopeptide complexing to the proteosomes. Our results suggest that the parameters affecting the immunogenicity of the peptide-proteosome complexes are: (i) hapten density, and (ii) size of the complex. Futhermore, sedimentation analysis of peptide-proteosome immunogens may serve as a rapidly performed assay of immunogenic potency. C1 JOHNS HOPKINS UNIV,SCH MED,DEPT PHARMACOL & MOLEC SCI,725 N WOLFE ST,BALTIMORE,MD 21205. WALTER REED ARMY MED CTR,DEPT BACTERIAL DIS,WASHINGTON,DC 20307. FU NCI NIH HHS [CA-09243]; NIAID NIH HHS [AI-19217] NR 25 TC 7 Z9 7 U1 0 U2 1 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0022-1759 J9 J IMMUNOL METHODS JI J. Immunol. Methods PD DEC 31 PY 1990 VL 135 IS 1-2 BP 101 EP 109 DI 10.1016/0022-1759(90)90262-T PG 9 WC Biochemical Research Methods; Immunology SC Biochemistry & Molecular Biology; Immunology GA EP295 UT WOS:A1990EP29500014 PM 2125617 ER PT J AU LIPPERT, LE FISHER, LM SCHOOK, LB AF LIPPERT, LE FISHER, LM SCHOOK, LB TI RELATIONSHIP OF MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-II GENES TO INHIBITOR ANTIBODY-FORMATION IN HEMOPHILIA-A SO THROMBOSIS AND HAEMOSTASIS LA English DT Article ID FACTOR-VIII GENE; HLA-DR; SEQUENCE-ANALYSIS; CDNA CLONE; DQ-BETA; CHAIN; POLYMORPHISMS; ANTIGENS; REGION AB Approximately 14% of transfused hemophiliacs develop an anti-factor VIII inhibitory antibody which specifically neutralizes factor VIII procoagulant activity. In this study an association of the major histocompatibility complex (MHC) with inhibitor antibody formation was evaluated by restriction fragment length polymorphism (RFLP) analysis using BamHI, EcoRI, HindIII, PstI, PvuII and TaqI digested genomic DNA probed with DP beta, DQ alpha, DQ beta and DR beta class II MHC gene probes. The RFLP patterns for 16 non-inhibitor and 11 inhibitor hemophiliac patients were analyzed. These 24 enzyme:probe combinations generated 231 fragment. Fifteen (15) fragments associated with the inhibitor phenotype; odds ratios ranged from 5.1 to 45 and lower bounds of 95% confidence intervals were > 1.000 for all 15 fragments. Five (5) fragments associated with non-inhibitors, with odds ratios ranging from 6.4 to 51.7. This report establishes a MHC related genetic basis for the inhibitor phenotype. No statistically significant differences in the distribution of serologically defined HLA-DR phenotypes were observed between the inhibitor and non-inhibitor groups. C1 VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,DEPT PATHOL,RICHMOND,VA 23298. UNIV ILLINOIS,DEPT ANIM SCI,MOLEC IMMUNOL LAB,URBANA,IL 61801. RP LIPPERT, LE (reprint author), WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307, USA. OI Schook, Lawrence/0000-0002-6580-8364 NR 42 TC 29 Z9 30 U1 0 U2 0 PU F K SCHATTAUER VERLAG GMBH PI STUTTGART PA P O BOX 10 45 45, LENZHALDE 3, D-70040 STUTTGART, GERMANY SN 0340-6245 J9 THROMB HAEMOSTASIS JI Thromb. Haemost. PD DEC 28 PY 1990 VL 64 IS 4 BP 564 EP 568 PG 5 WC Hematology; Peripheral Vascular Disease SC Hematology; Cardiovascular System & Cardiology GA ET846 UT WOS:A1990ET84600014 PM 1982196 ER PT J AU BLACK, PL USSERY, MA RANKIN, JT CHIRIGOS, MA AF BLACK, PL USSERY, MA RANKIN, JT CHIRIGOS, MA TI THERAPEUTIC ACTIVITY OF REVERSE-TRANSCRIPTASE INHIBITORS IN MURINE RETROVIRUS MODELS SO ANNALS OF THE NEW YORK ACADEMY OF SCIENCES LA English DT Article C1 US FDA, ROCKVILLE, MD 20857 USA. USA, MED RES INST INFECT DIS, FREDERICK, MD 21701 USA. RP BLACK, PL (reprint author), SO RES INST, FREDERICK RES CTR, 431 AVIAT WAY, FREDERICK, MD 21701 USA. NR 0 TC 0 Z9 0 U1 0 U2 0 PU NEW YORK ACAD SCIENCES PI NEW YORK PA 2 E 63RD ST, NEW YORK, NY 10021 USA SN 0077-8923 J9 ANN NY ACAD SCI JI Ann.NY Acad.Sci. PD DEC 26 PY 1990 VL 616 BP 486 EP 489 PG 4 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA FM709 UT WOS:A1990FM70900051 ER PT J AU MORREY, JD WARREN, RP OKLEBERRY, KM BURGER, RA SIDWELL, RW CHIRIGOS, MA AF MORREY, JD WARREN, RP OKLEBERRY, KM BURGER, RA SIDWELL, RW CHIRIGOS, MA TI EFFECT OF IMEXON ON FRIEND-VIRUS COMPLEX INFECTION IN RFV-3R/S GENOTYPE-CONTAINING MICE AS A MODEL FOR AIDS SO ANNALS OF THE NEW YORK ACADEMY OF SCIENCES LA English DT Article C1 USA, MED RES INST INFECT DIS, FT DETRICK, MD USA. RP MORREY, JD (reprint author), UTAH STATE UNIV, AIDS RES PROGRAM, LOGAN, UT 84322 USA. NR 2 TC 0 Z9 0 U1 0 U2 0 PU NEW YORK ACAD SCIENCES PI NEW YORK PA 2 E 63RD ST, NEW YORK, NY 10021 USA SN 0077-8923 J9 ANN NY ACAD SCI JI Ann.NY Acad.Sci. PD DEC 26 PY 1990 VL 616 BP 575 EP 578 PG 4 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA FM709 UT WOS:A1990FM70900077 ER PT J AU ROLLIN, PE KSIAZEK, TG JAHRLING, PB HAINES, M PETERS, CJ AF ROLLIN, PE KSIAZEK, TG JAHRLING, PB HAINES, M PETERS, CJ TI DETECTION OF EBOLA-LIKE VIRUSES BY IMMUNOFLUORESCENCE SO LANCET LA English DT Letter C1 USA,MED RES INST INFECT DIS,DIV DIS ASSESSMENT,FREDERICK,MD 21701. USA,MED RES INST INFECT DIS,DIV VET MED,FREDERICK,MD 21701. RP ROLLIN, PE (reprint author), INST PASTEUR,F-75724 PARIS 15,FRANCE. NR 4 TC 12 Z9 13 U1 1 U2 4 PU LANCET LTD PI LONDON PA 42 BEDFORD SQUARE, LONDON, ENGLAND WC1B 3SL SN 0140-6736 J9 LANCET JI Lancet PD DEC 22 PY 1990 VL 336 IS 8730 BP 1591 EP 1591 DI 10.1016/0140-6736(90)93378-3 PG 1 WC Medicine, General & Internal SC General & Internal Medicine GA EP037 UT WOS:A1990EP03700066 PM 1979412 ER PT J AU LATIFI, H BISWAS, A ARMSTRONG, RL PINNICK, RG AF LATIFI, H BISWAS, A ARMSTRONG, RL PINNICK, RG TI LASING AND STIMULATED RAMAN-SCATTERING IN SPHERICAL LIQUID DROPLETS - TIME, IRRADIANCE, AND WAVELENGTH DEPENDENCE SO APPLIED OPTICS LA English DT Article ID SIZE DROPLETS; RESONANCES; LASER; EMISSION; SPECTRA AB Measurement of lasing from dye doped micron sized ethanol droplets irradiated by a pulsed Nd:YAG laser shows evidence of lifetime broadening and relaxation oscillations. Observations of stimulated Raman scattering (SRS) and lasing generated by the same laser pulse in a dye doped ethanol droplet and coupled to the same morphology dependent resonance exhibit longer delays in the initiation of SRS than for pure ethanol droplets where lasing is absent. SRS emission above the plasma breakdown threshold is not measurably delayed and is quenched by the developing plasma. C1 ATMOSPHER SCI LAB,WHITE SANDS MISSILE RANGE,NM 88002. RP LATIFI, H (reprint author), NEW MEXICO STATE UNIV,DEPT PHYS,LAS CRUCES,NM 88003, USA. NR 19 TC 29 Z9 29 U1 0 U2 4 PU OPTICAL SOC AMER PI WASHINGTON PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 SN 0003-6935 J9 APPL OPTICS JI Appl. Optics PD DEC 20 PY 1990 VL 29 IS 36 BP 5387 EP 5392 PG 6 WC Optics SC Optics GA EQ685 UT WOS:A1990EQ68500016 PM 20577566 ER PT J AU OWENS, FJ AF OWENS, FJ TI FLUX FLOW INDUCED MICROWAVE-ABSORPTION IN HIGH-TEMPERATURE SUPERCONDUCTOR BI2-XPBXSR2CAN-1CUNO4+2N SO PHYSICS LETTERS A LA English DT Article ID OXIDES AB Direct measurements of microwave absorption without use of rf H field modulation in granular composites of the 115 K superconductor Bi(2-x)Pb(x)Sr2Ca(N-1)Cu(N)O4+2N as a function of magnetic field above 0.1 T reveal a continuing increase of absorption of microwave energy increasing magnetic field. The temperature and magnetic field dependence of the absorption are very different from the low magnetic field (< 0.01 T) absorption arising from weak links in the material. The magnetic field and temperature dependence are consistent with the behavior of thermally activated flux flow resistance suggesting the absorption is due to flux creep. C1 USA,CTR ARMAMENT RES & DEV,PICATINNY,NJ 07806. RP OWENS, FJ (reprint author), CUNY HUNTER COLL,DEPT PHYS,695 PK AVE,NEW YORK,NY 10021, USA. NR 18 TC 6 Z9 6 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0375-9601 J9 PHYS LETT A JI Phys. Lett. A PD DEC 17 PY 1990 VL 151 IS 6-7 BP 349 EP 352 DI 10.1016/0375-9601(90)90296-Z PG 4 WC Physics, Multidisciplinary SC Physics GA ET214 UT WOS:A1990ET21400018 ER PT J AU FRANKE, ED WIGNALL, FS CRUZ, ME ROSALES, E TOVAR, AA LUCAS, CM LLANOSCUENTAS, A BERMAN, JD AF FRANKE, ED WIGNALL, FS CRUZ, ME ROSALES, E TOVAR, AA LUCAS, CM LLANOSCUENTAS, A BERMAN, JD TI EFFICACY AND TOXICITY OF SODIUM STIBOGLUCONATE FOR MUCOSAL LEISHMANIASIS SO ANNALS OF INTERNAL MEDICINE LA English DT Article C1 CAYETANO HEREDIA UNIV,LIMA,PERU. CUZCO REG HOSP,CUZCO,PERU. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. RP FRANKE, ED (reprint author), USN,MED RES INST,DETACHMENT PERU,MIAMI,FL 34031, USA. RI Villasante, Eileen/G-3602-2011 NR 14 TC 90 Z9 91 U1 0 U2 1 PU AMER COLL PHYSICIANS PI PHILADELPHIA PA INDEPENDENCE MALL WEST 6TH AND RACE ST, PHILADELPHIA, PA 19106-1572 SN 0003-4819 J9 ANN INTERN MED JI Ann. Intern. Med. PD DEC 15 PY 1990 VL 113 IS 12 BP 934 EP 940 PG 7 WC Medicine, General & Internal SC General & Internal Medicine GA EM297 UT WOS:A1990EM29700007 PM 2173461 ER PT J AU HNATIUK, OW DILLARD, TA OSTER, CN AF HNATIUK, OW DILLARD, TA OSTER, CN TI BLEOMYCIN SCLEROTHERAPY FOR BILATERAL PNEUMOTHORACES IN A PATIENT WITH AIDS SO ANNALS OF INTERNAL MEDICINE LA English DT Note RP HNATIUK, OW (reprint author), WALTER REED ARMY MED CTR,DEPT CLIN INVEST,WASHINGTON,DC 20307, USA. NR 10 TC 14 Z9 14 U1 0 U2 0 PU AMER COLL PHYSICIANS PI PHILADELPHIA PA INDEPENDENCE MALL WEST 6TH AND RACE ST, PHILADELPHIA, PA 19106-1572 SN 0003-4819 J9 ANN INTERN MED JI Ann. Intern. Med. PD DEC 15 PY 1990 VL 113 IS 12 BP 988 EP 990 PG 3 WC Medicine, General & Internal SC General & Internal Medicine GA EM297 UT WOS:A1990EM29700015 PM 1700656 ER PT J AU HARRIS, LW ANDERSON, DR LENNOX, WJ WOODARD, CL PASTELAK, AM VANDERPOOL, BA AF HARRIS, LW ANDERSON, DR LENNOX, WJ WOODARD, CL PASTELAK, AM VANDERPOOL, BA TI EVALUATION OF SEVERAL OXIMES AS REACTIVATORS OF UNAGED SOMAN-INHIBITED WHOLE-BLOOD ACETYLCHOLINESTERASE IN RABBITS SO BIOCHEMICAL PHARMACOLOGY LA English DT Article ID INVITRO AB The antidotal benefit of oximes against organophosphorus (OP) anticholinesterase intoxication is thought to be due to reactivation of the OP-inhibited acetylcholinesterase (AChE). This study was conducted to determine whether the antidotal efficacy against soman by the oximes 2-hydroxyiminomethyl-3-methyl-1-[2-(3-methyl-3-nitrobutyl oxymethyl)]-imidazolium Cl (ICD 467) and 1,1'-methylenebis]4-(hydroxyiminomethyl) pyridinium] di-Cl (MMB-4) resulted, in part, from reactivation of the inhibited AChE. These oximes were tested in parallel with pralidoxime Cl (2-PAM) and 1-(2-hydroxyiminomethyl-1-pyridinio-3-(4-carbamoyl-1-pyridinio)-2-oxapropane di-Cl (HI-6). Rabbits were atropinized (8 mg/kg i.m.) and intoxicated with soman (13-mu-g/kg i.v.; 1.2 X LD50) 5 min later. Three minutes after soman, animals were treated with oxime (50, 100 or 150-mu-mol/kg, i.m.). Whole blood was collected from a catheter in the central artery of the ear just before soman, at 2 min after soman and at 2, 5, 10, 15, 30, and 60 min after oxime vehicle for determination of AChE activity. Shortly thereafter, animals were anesthetized and exsanguinated with immediate flushing using heparinized saline. AChE activity was also determined on the cortex, medulla-pons and diaphragm to assess central and peripheral reactivation. Treatment with HI-6 or MMB-4 (50-mu-mol/kg, i.m.) resulted in significant (P < 0.05) reactivation of soman-inhibited whole blood AChE and diaphragm cholinesterase (ChE), but not brain AChE. In contrast, 2-PAM was completely ineffective in reactivating soman-inhibited AChE. HI-6 was significantly better than MMB-4 in reactivating blood AChE; they were essentially equal against soman-inhibited diaphragm ChE. Three animals exposed to soman and treated with ICD 467 died within 15 min. When animals not exposed to soman were treated with ICD 467 (25-mu-mol/kg, i.m.), whole blood AChE activity was depressed by 60% within 5-10 min after treatment. Furthermore, ICD 467 failed to reactivate significantly unaged soman-inhibited erythrocyte AChE, in vitro. These observation indicate that ICD 467 would be contraindicated as a therapy for anti-ChE intoxication and that the efficacy of HI-6 or MMB-4 can be explained, in part, by reactivation of soman-inhibited AChE. RP HARRIS, LW (reprint author), USA,MED RES INST CHEM DEF,APPL PHARMACOL BRANCH,ABERDEEN PROVING GROUND,MD 21010, USA. NR 21 TC 21 Z9 21 U1 0 U2 1 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB SN 0006-2952 J9 BIOCHEM PHARMACOL JI Biochem. Pharmacol. PD DEC 15 PY 1990 VL 40 IS 12 BP 2677 EP 2682 DI 10.1016/0006-2952(90)90586-A PG 6 WC Pharmacology & Pharmacy SC Pharmacology & Pharmacy GA EP086 UT WOS:A1990EP08600014 PM 2260991 ER PT J AU BLANEY, SM BALIS, FM HEGEDUS, L HEIDEMAN, RL MCCULLY, C MURPHY, RF KELLEY, JA POPLACK, DG AF BLANEY, SM BALIS, FM HEGEDUS, L HEIDEMAN, RL MCCULLY, C MURPHY, RF KELLEY, JA POPLACK, DG TI PHARMACOKINETICS AND METABOLISM OF CYCLOPENTENYL CYTOSINE IN NONHUMAN-PRIMATES SO CANCER RESEARCH LA English DT Article C1 NCI,MED CHEM LAB,BETHESDA,MD 20892. WALTER REED ARMY MED CTR,WASHINGTON,DC 20307. RP BLANEY, SM (reprint author), NCI,PEDIAT BRANCH,BLDG 10,ROOM 13N240,9000 ROCKVILLE PIKE,BETHESDA,MD 20892, USA. NR 25 TC 17 Z9 17 U1 0 U2 0 PU AMER ASSOC CANCER RESEARCH PI PHILADELPHIA PA PUBLIC LEDGER BLDG, SUITE 816, 150 S. INDEPENDENCE MALL W., PHILADELPHIA, PA 19106 SN 0008-5472 J9 CANCER RES JI Cancer Res. PD DEC 15 PY 1990 VL 50 IS 24 BP 7915 EP 7919 PG 5 WC Oncology SC Oncology GA EM165 UT WOS:A1990EM16500034 PM 2253232 ER PT J AU WHITEAKER, RS AF WHITEAKER, RS TI FROM RAGS TO USEFULNESS SO DATAMATION LA English DT Letter C1 USA,SAN ANTONIO,TX. NR 0 TC 0 Z9 0 U1 0 U2 0 PU CAHNERS-DENVER PUBLISHING CO PI HIGHLANDS RANCH PA 8773 S RIDGELINE BLVD, HIGHLANDS RANCH, CO 80126-2329 SN 0011-6963 J9 DATAMATION JI Datamation PD DEC 15 PY 1990 VL 36 IS 24 BP 12 EP 12 PG 1 WC Computer Science, Hardware & Architecture; Computer Science, Software Engineering SC Computer Science GA EM979 UT WOS:A1990EM97900005 ER PT J AU FOLKES, PA AF FOLKES, PA TI FLUCTUATING DEEP-LEVEL TRAP OCCUPANCY MODEL FOR 1/F NOISE IN SEMICONDUCTOR RESISTORS SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID FIELD-EFFECT TRANSISTORS; 1-F NOISE; ELECTRON-MOBILITY; GAAS; RECOMBINATION; STATES; BULK AB A quantitative theoretical model for 1/f and low-frequency noise due to bulk traps in semiconductor resistors has been developed. The model is based on the fact that random fluctuations of the steady-state deep-level-trapped electron density, at some point in a depletion layer, decay exponentially with a relaxation time which depends on the local free electron density, the intrinsic properties of the semiconductor and the trap energy. The model, which is valid for relaxation times which are much longer than the free electron transit time, was applied to the case of a Schottky-barrier field effect resistor. Our results show that the low-frequency noise spectrum generated by deep-level traps with a broad spatial distribution throughout the depletion layer, is very sensitive to Fermi-Dirac trap statistics. The discrete distribution of flatband trap energy levels is the crucial parameter which determines the spectral density and range of the low-frequency noise. Monoenergetic traps generate a considerably broadened Lorentzianlike low-frequency noise spectrum which is highly sensitive to temperature. Traps with an arbitrary distribution over a set of discrete energy levels may exhibit 1/f noise or generic low-frequency noise. We deduce the condition that has to be satisfied in order for an arbitrary discrete distribution of bulk traps over energy to exhibit 1/f noise and derive an exact integral and approximate analytical expressions for the spectral density and range of bulk 1/f noise in semiconductors. The temperature dependence of the 1/f noise spectrum is discussed while in the process elucidating the subtle temperature-dependent relationship between 1/f and low-frequency noise arising from bulk traps. Experimentally observed low-frequency and 1/f noise characteristics are explicitly accounted for by the model. A qualitative argument for the application of the model to 1/f noise generated by surface traps is given. RP FOLKES, PA (reprint author), USA,ELECTR TECHNOL & DEVICES LAB,FT MONMOUTH,NJ 07703, USA. NR 35 TC 7 Z9 7 U1 1 U2 1 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD DEC 15 PY 1990 VL 68 IS 12 BP 6279 EP 6288 DI 10.1063/1.346870 PG 10 WC Physics, Applied SC Physics GA EP011 UT WOS:A1990EP01100044 ER PT J AU KIM, KW STROSCIO, MA AF KIM, KW STROSCIO, MA TI ELECTRON-OPTICAL-PHONON INTERACTION IN BINARY TERNARY HETEROSTRUCTURES SO JOURNAL OF APPLIED PHYSICS LA English DT Article ID SCATTERING; POLARIZABILITY; SEMICONDUCTOR; SLAB AB The macroscopic dielectric continuum model is used to derive electron-optical-phonon interaction Hamiltonians for binary/ternary heterostructures containing both single and double heterointerfaces. The formulation presented in this work leads to a general prescription for the calculation of mode-strength coefficients in ternary-containing heterostructures. An illustration of these results is provided by exhibiting the mode strengths of the interaction Hamiltonians for the interface and the half-space longitudinal optical modes in a GaAs/Al(y)Ga(1-y)As single heterostructure. C1 USA,RES OFF,RES TRIANGLE PK,NC 27709. RP KIM, KW (reprint author), N CAROLINA STATE UNIV,DEPT ELECT & COMP ENGN,RALEIGH,NC 27695, USA. NR 18 TC 62 Z9 63 U1 0 U2 4 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD DEC 15 PY 1990 VL 68 IS 12 BP 6289 EP 6293 DI 10.1063/1.346871 PG 5 WC Physics, Applied SC Physics GA EP011 UT WOS:A1990EP01100045 ER PT J AU DONALDSON, WR KINGSLEY, L WEINER, M KIM, A ZETO, R AF DONALDSON, WR KINGSLEY, L WEINER, M KIM, A ZETO, R TI ELECTROOPTIC IMAGING OF THE INTERNAL FIELDS IN A GAAS PHOTOCONDUCTIVE SWITCH SO JOURNAL OF APPLIED PHYSICS LA English DT Article AB A technique has been developed that allows single-shot measurement of the electric field over an extended area. A LiTaO3 crystal, covering the entire active area of the GaAs photoconductive switch, coupled the surface field with the polarization of an optical probe pulse. When imaged onto a two-dimensional detector array, this system produced snapshots of the surface field profile with 200-ps time resolution and 3-mu-m spatial resolution. The technique was used to monitor the collapse of the electric field in the GaAs as it was switched with a lambda = 1.06 mu-m optical pulse. The switching speed and generation of field enhancements were found to be dependent on the illumination configuration and the electric field. In particular, the switching efficiency was found to decrease with increasing field. C1 USA,ELECTR TECHNOL & DEVICE LAB,FT MONMOUTH,NJ 07703. RP DONALDSON, WR (reprint author), UNIV ROCHESTER,LASER ENERGET LAB,250 E RIVER RD,ROCHESTER,NY 14623, USA. NR 7 TC 10 Z9 10 U1 0 U2 0 PU AMER INST PHYSICS PI WOODBURY PA CIRCULATION FULFILLMENT DIV, 500 SUNNYSIDE BLVD, WOODBURY, NY 11797-2999 SN 0021-8979 J9 J APPL PHYS JI J. Appl. Phys. PD DEC 15 PY 1990 VL 68 IS 12 BP 6453 EP 6457 DI 10.1063/1.346843 PG 5 WC Physics, Applied SC Physics GA EP011 UT WOS:A1990EP01100073 ER PT J AU GREEN, SJ CRAWFORD, RM HOCKMEYER, JT MELTZER, MS NACY, CA AF GREEN, SJ CRAWFORD, RM HOCKMEYER, JT MELTZER, MS NACY, CA TI LEISHMANIA-MAJOR AMASTIGOTES INITIATE THE L-ARGININE-DEPENDENT KILLING MECHANISM IN IFN-GAMMA-STIMULATED MACROPHAGES BY INDUCTION OF TUMOR-NECROSIS-FACTOR-ALPHA SO JOURNAL OF IMMUNOLOGY LA English DT Article ID CYTO-TOXICITY; MURINE MACROPHAGES; GAMMA-INTERFERON; NITRIC-OXIDE; SCHISTOSOMA-MANSONI; EFFECTOR MECHANISM; RESPIRATORY BURST; TARGET-CELLS; ACTIVATION; INHIBITION AB Macrophages exposed to IFN-gamma and infected with amastigotes of Leishmania major develop the capacity to eliminate the intracellular pathogen. This antimicrobial activity of activated macrophages correlates with the initiation of nitrogen oxidation of L-arginine, yet other reports suggest that two signals are required for induction of this biochemical pathway for effector activity. In the present studies, macrophages treated with up to 100 U/ml IFN-gamma, or 100 ng LPS, or 10(7) amastigotes produced minimal quantities ( < 9-mu-M) of NO2- and failed to develop cytotoxic effector activities. In contrast, the combination of IFN-gamma and either LPS ( > 0.1 ng) or amastigotes (10(6)) induced high concentrations ( >> 30-mu-M) of NO2- and macrophage cytotoxicity against intra- and extracellular targets. The induction of nitrogen oxidation by amastigotes could be dissociated from LPS-induced events by 1) performing the assays in the presence of polymyxin B (which blocked LPS effects, but not amastigote effects), 2) determining the threshold of IFN-gamma required to prime cells for subsequent trigger (1 U/ml for LPS trigger effects; 10-fold higher for amastigotes), and 3) determining the heat sensitivity of the two trigger agents (amastigote effects abolished at 100-degrees-C; LPS effects unaffected at this temperature). Further, culture fluids from amastigote-infected macrophages did not contain detectable LPS ( < 6 pg/ml). Possible parasite and cell-associated factors that could contribute to the induction of nitrogen oxidation and cytotoxic activity of IFN-gamma treated macrophages were examined: only certain intact microorganisms, LPS from a variety of bacteria, and the cytokine TNF-alpha were effective. Both NO2- production and intracellular killing were abolished by the addition of of anti-TNF-alpha mAb in the assay. TNF-alpha was produced by amastigote-infected macrophages and IFN-gamma dramatically enhanced secretion of this cytokine; IFN-gamma alone had no effect. Endogenous TNF-alpha produced during infection of macrophages with L. major acted in an autocrine fashion to trigger the production of L-arginine-derived toxic nitrogen intermediates that killed the intracellular parasites. C1 WALTER REED ARMY MED CTR,DEPT CELLULAR IMMUNOL,WASHINGTON,DC 20307. NR 51 TC 407 Z9 413 U1 0 U2 2 PU AMER ASSOC IMMUNOLOGISTS PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0022-1767 J9 J IMMUNOL JI J. Immunol. PD DEC 15 PY 1990 VL 145 IS 12 BP 4290 EP 4297 PG 8 WC Immunology SC Immunology GA EP041 UT WOS:A1990EP04100048 PM 2124240 ER PT J AU RUDIN, S REINECKE, TL SEGALL, B AF RUDIN, S REINECKE, TL SEGALL, B TI TEMPERATURE-DEPENDENT EXCITON LINEWIDTHS IN SEMICONDUCTORS SO PHYSICAL REVIEW B LA English DT Article C1 USN,RES LAB,WASHINGTON,DC 20375. CASE WESTERN RESERVE UNIV,CLEVELAND,OH 44106. RP RUDIN, S (reprint author), USA,ELECTR TECHNOL & DEVICES LAB,FT MONMOUTH,NJ 07703, USA. NR 41 TC 260 Z9 261 U1 3 U2 21 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 1098-0121 J9 PHYS REV B JI Phys. Rev. B PD DEC 15 PY 1990 VL 42 IS 17 BP 11218 EP 11231 DI 10.1103/PhysRevB.42.11218 PG 14 WC Physics, Condensed Matter SC Physics GA EM727 UT WOS:A1990EM72700049 ER PT J AU LEAVITT, RP LITTLE, JW AF LEAVITT, RP LITTLE, JW TI SIMPLE METHOD FOR CALCULATING EXCITON BINDING-ENERGIES IN QUANTUM-CONFINED SEMICONDUCTOR STRUCTURES SO PHYSICAL REVIEW B LA English DT Article ID ELECTRIC-FIELD DEPENDENCE; WELL STRUCTURES; WANNIER EXCITONS; ELECTROABSORPTION; NONPARABOLICITY; GAP AB We present a simple, general method for calculating the binding energies of excitons in quantum-confined structures. The binding energy is given by an integral (over the electron and hole coordinates perpendicular to the confining layers) of a prescribed function weighted by the squares of the electron and hole subband envelope functions. As a test of the method, we calculate the binding energies for heavy- and light-hole excitons in a rectangular GaAs/Al0.3Ga0.7As quantum well as functions of the well width. Very good agreement with previous results is obtained over a wide range of quantum-well widths. Also, we determine the binding energies for heavy-hole excitons as functions of electric field in a GaAs/Al0.35Ga0.65As asymmetric coupled-quantum-well structure. Our results compare favorably with those obtained in a treatment in which coupling of the electron subbands via the electron-hole Coulomb interaction is considered. Our method should be applicable to a variety of complex quantum-confined semiconductor structures for which more rigorous approaches require extensive numerical calculations. C1 MARTIN MARIETTA CORP LABS,BALTIMORE,MD 21227. RP LEAVITT, RP (reprint author), HARRY DIAMOND LABS,USA,LAB COMMAND,2800 POWDER MILL RD,ADELPHI,MD 20783, USA. NR 27 TC 114 Z9 115 U1 0 U2 3 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0163-1829 J9 PHYS REV B JI Phys. Rev. B PD DEC 15 PY 1990 VL 42 IS 18 BP 11774 EP 11783 DI 10.1103/PhysRevB.42.11774 PG 10 WC Physics, Condensed Matter SC Physics GA EP284 UT WOS:A1990EP28400036 ER PT J AU LEAVITT, RP LITTLE, JW AF LEAVITT, RP LITTLE, JW TI EXCITONIC EFFECTS IN THE OPTICAL-SPECTRA OF SUPERLATTICES IN AN ELECTRIC-FIELD SO PHYSICAL REVIEW B LA English DT Article ID QUANTUM WELLS; ABSORPTION; LOCALIZATION; PARAMETERS AB We consider theoretically the optical spectra of electron-hole Stark-ladder transitions in superlattices under an electric field. Electron and heavy-hole subband energies and envelope functions are calculated using a scattering phase-shift treatment of the quasibound, Stark-localized states. Exciton binding energies and oscillator strengths are obtained as functions of the electric field for several pairs of Stark-localized electron and hole states. Accurate and rapid computation of these quantities is achieved by using the simple approximation developed in the preceding paper. We show that observed deviations of the Stark-ladder fan diagram from the expected linear dependence on electric fields results from excitonic effects. We also calculate the absorption coefficient as a function of photon energy for various electric fields, and we compare our results with recent experimental data on short-period GaAs/Al(x)Ga1-xAs superlattices. C1 MARTIN MARIETTA CORP LABS,BALTIMORE,MD 21227. RP LEAVITT, RP (reprint author), HARRY DIAMOND LABS,USA,LAB COMMAND,2800 POWDER MILL RD,ADELPHI,MD 20783, USA. NR 25 TC 24 Z9 24 U1 0 U2 0 PU AMERICAN PHYSICAL SOC PI COLLEGE PK PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA SN 0163-1829 J9 PHYS REV B JI Phys. Rev. B PD DEC 15 PY 1990 VL 42 IS 18 BP 11784 EP 11790 DI 10.1103/PhysRevB.42.11784 PG 7 WC Physics, Condensed Matter SC Physics GA EP284 UT WOS:A1990EP28400037 ER PT J AU CHOUDHURY, S KARARA, AH ACE, LN MCFARLAND, VA AF CHOUDHURY, S KARARA, AH ACE, LN MCFARLAND, VA TI HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC METHOD FOR THE DETERMINATION OF 3-METHYLCHOLANTHRENE IN CHANNEL CATFISH PLASMA SO JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS LA English DT Note C1 NE LOUISIANA UNIV,SCH PHARM,DIV PHARMACEUT & MED CHEM,MONROE,LA 71209. SANDOZ INC,RES INST,DRUG METAB,E HANOVER,NJ 07936. USA,ENGN WATERWAYS EXPT STN,VICKSBURG,MS 39180. NR 6 TC 1 Z9 1 U1 0 U2 0 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0378-4347 J9 J CHROMATOGR-BIOMED JI J. Chromatogr.-Biomed. Appl. PD DEC 14 PY 1990 VL 534 BP 208 EP 213 DI 10.1016/S0378-4347(00)82164-7 PG 6 WC Chemistry, Analytical SC Chemistry GA ET068 UT WOS:A1990ET06800022 PM 2094708 ER PT J AU DALY, SF AF DALY, SF TI FRAZIL ICE SO SCIENCE LA English DT Letter RP DALY, SF (reprint author), USA,CORPS ENGINEERS,COLD REG RES & ENGN LAB,ICE ENGN RES BRANCH,HANOVER,NH 03755, USA. NR 1 TC 0 Z9 0 U1 0 U2 3 PU AMER ASSOC ADVANCEMENT SCIENCE PI WASHINGTON PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 SN 0036-8075 J9 SCIENCE JI Science PD DEC 14 PY 1990 VL 250 IS 4987 BP 1498 EP 1498 PG 1 WC Multidisciplinary Sciences SC Science & Technology - Other Topics GA EM931 UT WOS:A1990EM93100003 ER PT J AU MIDDAUGH, RE MENK, EJ AF MIDDAUGH, RE MENK, EJ TI SUBSTANCE-ABUSE AND ANESTHESIOLOGY TRAINING - REPLY SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION LA English DT Letter RP MIDDAUGH, RE (reprint author), BROOKE ARMY MED CTR,FT SAM HOUSTON,TX 78234, USA. NR 2 TC 0 Z9 0 U1 0 U2 0 PU AMER MEDICAL ASSOC PI CHICAGO PA 515 N STATE ST, CHICAGO, IL 60610 SN 0098-7484 J9 JAMA-J AM MED ASSOC JI JAMA-J. Am. Med. Assoc. PD DEC 5 PY 1990 VL 264 IS 21 BP 2741 EP 2742 PG 2 WC Medicine, General & Internal SC General & Internal Medicine GA EK537 UT WOS:A1990EK53700026 ER PT J AU WILLIAMSON, KC SMITH, LA MOSS, J VAUGHAN, M AF WILLIAMSON, KC SMITH, LA MOSS, J VAUGHAN, M TI GUANINE NUCLEOTIDE-DEPENDENT ADP-RIBOSYLATION OF SOLUBLE RHO CATALYZED BY CLOSTRIDIUM-BOTULINUM C3 ADP-RIBOSYLTRANSFERASE - ISOLATION AND CHARACTERIZATION OF A NEWLY RECOGNIZED FORM OF RHOA SO JOURNAL OF BIOLOGICAL CHEMISTRY LA English DT Article C1 USA,MED RES INST INFECT DIS,DIV PATHOL,FREDERICK,MD 21701. RP WILLIAMSON, KC (reprint author), NHLBI,CELLULAR METAB LAB,BLDG 10,RM 5N307,BETHESDA,MD 20892, USA. NR 41 TC 15 Z9 16 U1 1 U2 1 PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC PI BETHESDA PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 SN 0021-9258 J9 J BIOL CHEM JI J. Biol. Chem. PD DEC 5 PY 1990 VL 265 IS 34 BP 20807 EP 20812 PG 6 WC Biochemistry & Molecular Biology SC Biochemistry & Molecular Biology GA EL020 UT WOS:A1990EL02000016 PM 2174426 ER PT J AU KIM, SB WAGER, JF MORTON, DC AF KIM, SB WAGER, JF MORTON, DC TI DIAMOND-LIKE CARBON-FILMS FOR ELECTROLUMINESCENT APPLICATIONS SO SURFACE & COATINGS TECHNOLOGY LA English DT Article; Proceedings Paper CT 17TH INTERNATIONAL CONF ON METALLURGICAL COATINGS / 8TH INTERNATIONAL CONF ON THIN FILMS CY APR 02-06, 1990 CL SAN DIEGO, CA SP AMER VACUUM SOC, DIV VACUUM MET, INT UNION VACUUM SCI, DIV THIN FILM ID PHOTO-LUMINESCENCE; DEVICES AB Diamond-like carbon (DLC) films grown by plasma-enhanced chemical vapor deposition are employed for the first time as an active layer in an alternating current (a.c.) thin-film electroluminescent (ACTFEL) device configuration. The ACTFEL device configuration consists of the DLC active layer sandwiched between two insulating layers which are contacted by a reflecting and transparent electrode. A large a.c. waveform with a small duty cycle is applied with a sufficiently large amplitude so that the DLC layer electrically breaks down; the insulators prevent this breakdown from being catastrophic. Electroluminescence arises from radiative recombination of electrons and holes via bandtail-to-bandtail states. This type of luminescence is inherently very broad band and the electroluminescence appears white. We have been able to produce electroluminescent emission well into the UV region of the electromagnetic spectrum so that these devices are potentially useful for visible and UV applications. The brightness and efficiency of our devices are very low to date: 0.5 ft lambert and 0.002 1m W-1. C1 USA,ELECTR TECHNOL & DEVICES LAB,FT MONMOUTH,NJ 07703. RP KIM, SB (reprint author), OREGON STATE UNIV,CTR ADV MAT RES,DEPT ELECT & COMP ENGN,CORVALLIS,OR 97331, USA. NR 13 TC 6 Z9 7 U1 0 U2 1 PU ELSEVIER SCIENCE SA LAUSANNE PI LAUSANNE 1 PA PO BOX 564, 1001 LAUSANNE 1, SWITZERLAND SN 0257-8972 J9 SURF COAT TECH JI Surf. Coat. Technol. PD DEC 5 PY 1990 VL 43-4 IS 1-3 BP 99 EP 106 DI 10.1016/0257-8972(90)90064-J PG 8 WC Materials Science, Coatings & Films; Physics, Applied SC Materials Science; Physics GA EP995 UT WOS:A1990EP99500013 ER PT J AU KATTAMIS, TZ CHANG, F LEVY, M AF KATTAMIS, TZ CHANG, F LEVY, M TI EVALUATION OF ADHESION OF SOME METALLIC COATINGS ON A DEPLETED U-0.75TI ALLOY SO SURFACE & COATINGS TECHNOLOGY LA English DT Article; Proceedings Paper CT 17TH INTERNATIONAL CONF ON METALLURGICAL COATINGS / 8TH INTERNATIONAL CONF ON THIN FILMS CY APR 02-06, 1990 CL SAN DIEGO, CA SP AMER VACUUM SOC, DIV VACUUM MET, INT UNION VACUUM SCI, DIV THIN FILM AB The adhesion, soundness and comparative quality of various coatings on a depleted uranium (DU-0.75Ti) alloy were evaluated with a CSEM Revetest automatic scratch tester. These coatings, namely aluminum, magnesium, zinc, titanium, Al-Zn, Al-Mg, TiN and Al/TiN, were deposited by a cathodic arc plasma physical vapor deposition process. During scratch testing the acoustic emission signal intensity, the frictional force and the friction coefficient were plotted vs. load. Scratch test results were correlated with coating microstructure characteristics as determined by optical and scanning electron microscopy. Al-Zn and Al-Mg coatings exhibit higher cohesive and adhesive (critical) loads and appear to be the best sacrificial coating materials for DU-0.75Ti. C1 USA,MAT TECHNOL LAB,WATERTOWN,MA 02172. RP KATTAMIS, TZ (reprint author), UNIV CONNECTICUT,DEPT MET,STORRS,CT 06269, USA. NR 11 TC 7 Z9 9 U1 1 U2 3 PU ELSEVIER SCIENCE SA LAUSANNE PI LAUSANNE 1 PA PO BOX 564, 1001 LAUSANNE 1, SWITZERLAND SN 0257-8972 J9 SURF COAT TECH JI Surf. Coat. Technol. PD DEC 5 PY 1990 VL 43-4 IS 1-3 BP 390 EP 401 DI 10.1016/0257-8972(90)90091-P PG 12 WC Materials Science, Coatings & Films; Physics, Applied SC Materials Science; Physics GA EP995 UT WOS:A1990EP99500040 ER PT J AU MOYER, MP HUOT, RI RAMIREZ, A JOE, S MELTZER, MS GENDELMAN, HE AF MOYER, MP HUOT, RI RAMIREZ, A JOE, S MELTZER, MS GENDELMAN, HE TI INFECTION OF HUMAN GASTROINTESTINAL CELLS BY HIV-1 SO AIDS RESEARCH AND HUMAN RETROVIRUSES LA English DT Article ID HUMAN IMMUNODEFICIENCY VIRUS; RECTAL MUCOSA; T-CELLS; AIDS; EXPRESSION; MONOCYTES; PATHOGENESIS; ENTEROPATHY; RETROVIRUS; INDUCTION AB Human immunodeficiency virus (HIV-1) infected and replicated in primary cultures of normal human ileal and colonic epithelial cells. Monocyte-tropic strains (ADA, 24, and 36) were better able to replicate in the gastrointestinal (GI) cells than the T-cell-tropic HIV strain HTLV-IIIB. In some cultures, virus replication persisted through several months. Intestinal epithelium may be an initial target and reservoir for HIV and a vector for virus dissemination and transmission. C1 UNIV TEXAS,HLTH SCI CTR,CTR HUMAN CELL BIOTECHNOL,DEPT MICROBIOL,SAN ANTONIO,TX 78284. WALTER REED ARMY MED CTR,DEPT CELLULAR IMMUNOL,HIV IMMUNOPATHOGENESIS PROGRAM,WASHINGTON,DC 20307. HENRY M JACKSON FDN ADVANCEMENT MIL MED,ROCKVILLE,MD. RP MOYER, MP (reprint author), UNIV TEXAS,HLTH SCI CTR,CTR HUMAN CELL BIOTECHNOL,DEPT SURG,7703 FLOYD CURL DR,SAN ANTONIO,TX 78284, USA. FU NIDDK NIH HHS [DK40625] NR 46 TC 57 Z9 57 U1 1 U2 1 PU MARY ANN LIEBERT INC PUBL PI LARCHMONT PA 2 MADISON AVENUE, LARCHMONT, NY 10538 SN 0889-2229 J9 AIDS RES HUM RETROV JI Aids Res. Hum. Retrovir. PD DEC PY 1990 VL 6 IS 12 BP 1409 EP 1415 DI 10.1089/aid.1990.6.1409 PG 7 WC Immunology; Infectious Diseases; Virology SC Immunology; Infectious Diseases; Virology GA ET189 UT WOS:A1990ET18900007 PM 2078418 ER PT J AU WISWELL, TE AF WISWELL, TE TI ROUTINE NEONATAL CIRCUMCISION - REPLY SO AMERICAN FAMILY PHYSICIAN LA English DT Letter RP WISWELL, TE (reprint author), WALTER REED ARMY MED CTR,WASHINGTON,DC 20307, USA. NR 0 TC 2 Z9 2 U1 0 U2 0 PU AMER ACAD FAMILY PHYSICIANS PI KANSAS CITY PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 SN 0002-838X J9 AM FAM PHYSICIAN JI Am. Fam. Physician PD DEC PY 1990 VL 42 IS 6 BP 1536 EP 1537 PG 2 WC Primary Health Care; Medicine, General & Internal SC General & Internal Medicine GA EL698 UT WOS:A1990EL69800006 ER EF