FN Thomson Reuters Web of Science™
VR 1.0
PT J
AU DiCorato, AE
Asenath-Smith, E
Kulak, AN
Meldrum, FC
Estroff, LA
AF DiCorato, Allessandra E.
Asenath-Smith, Emily
Kulak, Alex N.
Meldrum, Fiona C.
Estroff, Lara A.
TI Cooperative Effects of Confinement and Surface Functionalization Enable
the Formation of Au/Cu2O Metal-Semiconductor Heterostructures
SO CRYSTAL GROWTH & DESIGN
LA English
DT Article
ID CALCITE SINGLE-CRYSTALS; CORE-SHELL NANOPARTICLES; NANOSCALE
CONFINEMENT; LATEX-PARTICLES; ZINC-OXIDE; CHEMICAL-DEPOSITION; GOLD
NANOPARTICLES; CRYSTALLIZATION; OCCLUSION; NUCLEATION
AB A promising approach to obtaining multifunctional materials with tunable properties is the incorporation of second phase constituents (e.g., particles, fibers) within inorganic crystals. To date, however, the specific chemical and physical controls over incorporation are only known for a few select systems. In this study, a simple wedge is used as a confining structure to systematically control the chemical and physical aspects of the crystallization microenvironment to promote the interaction between copper(I) oxide (Cu2O) crystals and alkanethiol-functionalized gold nanoparticles (Au np), producing a metal semiconductor composite. Physically, the confining wedge geometry provides (vapor) diffusion-limited growth conditions. Chemically functionalizing both the Au np surfaces and the glass slides that form the wedge promotes the interaction of Au np with the growing Cu2O crystals. The physical confinement of the wedge structure, as well as optimization of its surface chemistry, is required to achieve this interaction. These findings demonstrate that Au/Cu2O can be used as a model system to inform the synthesis of other metal semiconductor heterostructures.
C1 [DiCorato, Allessandra E.] Cornell Univ, Dept Chem & Chem Biol, Baker Lab, Ithaca, NY 14853 USA.
[Asenath-Smith, Emily; Estroff, Lara A.] Cornell Univ, Dept Mat Sci & Engn, Bard Hall, Ithaca, NY 14853 USA.
[Kulak, Alex N.; Meldrum, Fiona C.] Univ Leeds, Sch Chem, Leeds LS2 9JT, W Yorkshire, England.
[Estroff, Lara A.] Cornell Univ, Kavli Inst Nanoscale Sci, Phys Sci Bldg, Ithaca, NY 14853 USA.
[DiCorato, Allessandra E.] Northwestern Univ, Dept Mat Sci & Engn, Evanston, IL 60208 USA.
[Asenath-Smith, Emily] US Army Engineer & Res & Dev Ctr ERDC, CRREL, Hanover, NH 03755 USA.
RP Asenath-Smith, E; Estroff, LA (reprint author), Cornell Univ, Dept Mat Sci & Engn, Bard Hall, Ithaca, NY 14853 USA.; Estroff, LA (reprint author), Cornell Univ, Kavli Inst Nanoscale Sci, Phys Sci Bldg, Ithaca, NY 14853 USA.; Asenath-Smith, E (reprint author), US Army Engineer & Res & Dev Ctr ERDC, CRREL, Hanover, NH 03755 USA.
EM emily.asenath-smith@usace.army.mil; lae37@cornell.edu
FU NSF Materials World Network Program [DMR 1210304]; Cornell University
College of Arts and Sciences through the Einhorn Discovery Grant;
Cornell Abroad and Undergraduate Research Funding Programs; NSF Graduate
Research Fellowship (GRF) [DGE-0707428]; Integrative Graduate Education
and Research Traineeship (IGERT) Programs [DGE-0903653]; Cornell Center
for Materials Research (CCMR); NSF MRSEC program [DMR 1120296];
Engineering and Physical Sciences Research Council (EPSRC) Materials
World Network grant [EP/J018589/1]; EPSRC [EP/K006304/1]
FX We acknowledge support from the NSF Materials World Network Program (DMR
1210304, LAE). A.E.D. acknowledges funding from the Cornell University
College of Arts and Sciences through the Einhorn Discovery Grant and the
Cornell Abroad and Undergraduate Research Funding Programs. E.A.S.
acknowledges the NSF Graduate Research Fellowship (GRF, DGE-0707428) and
Integrative Graduate Education and Research Traineeship (IGERT,
DGE-0903653) Programs. This work was also supported in part by The
Cornell Center for Materials Research (CCMR) and made use of the CCMR
Shared Facilities, both funded by NSF MRSEC program (DMR 1120296). We
also acknowledge support from an Engineering and Physical Sciences
Research Council (EPSRC) Materials World Network grant (EP/J018589/1,
FCM) and EPSRC grant EP/K006304/1 (F.C.M. and A.N.K.). This work made
use of the Nanobiotechnology Center for Shared Research at Cornell
University.
NR 61
TC 1
Z9 1
U1 19
U2 19
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1528-7483
EI 1528-7505
J9 CRYST GROWTH DES
JI Cryst. Growth Des.
PD DEC
PY 2016
VL 16
IS 12
BP 6804
EP 6811
DI 10.1021/acs.cgd.6b00913
PG 8
WC Chemistry, Multidisciplinary; Crystallography; Materials Science,
Multidisciplinary
SC Chemistry; Crystallography; Materials Science
GA EE5DD
UT WOS:000389624200018
ER
PT J
AU Sider, J
AF Sider, Justin
TI DRAMATIC MONOLOGUE, PUBLIC ADDRESS, AND THE ENDS OF CHARACTER
SO ELH
LA English
DT Article
C1 [Sider, Justin] US Mil Acad, West Point, NY 10996 USA.
RP Sider, J (reprint author), US Mil Acad, West Point, NY 10996 USA.
NR 53
TC 0
Z9 0
U1 0
U2 0
PU JOHNS HOPKINS UNIV PRESS
PI BALTIMORE
PA JOURNALS PUBLISHING DIVISION, 2715 NORTH CHARLES ST, BALTIMORE, MD
21218-4363 USA
SN 0013-8304
EI 1080-6547
J9 ELH
JI ELH
PD WIN
PY 2016
VL 83
IS 4
BP 1135
EP 1158
PG 24
WC Literature
SC Literature
GA EE9RZ
UT WOS:000389965200008
ER
PT J
AU Lafond, PG
Izvekov, S
AF Lafond, Patrick G.
Izvekov, Sergei
TI Multiscale Coarse-Graining of Polarizable Models through Force Matched
Dipole Fluctuations
SO JOURNAL OF CHEMICAL THEORY AND COMPUTATION
LA English
DT Article
ID MOLECULAR-DYNAMICS SIMULATION; UNITED-ATOM DESCRIPTION; TRANSFERABLE
POTENTIALS; PHASE-EQUILIBRIA; DIELECTRIC PERMITTIVITY; WATER; TRANSPORT;
FIELD; RELAXATION; SECONDARY
AB An extension of the multiscale coarse-graining method (MS-CG) to polarizable coarse-grain (CG) models is presented. In the extension, force matching is used to derive charged dimers that mimic the dipole behavior, including electronic polarizability, of fine resolution systems. The extended MS-CG method separates short-range and electrostatic forces and treats the polarization interactions by representing dipole fluctuations with a harmonic bond reminiscent of the Drude oscillator. The new method is first tested on several flexible alcohols, where the transferable head groups in the atomistic field lead to transferable electrostatics in the CG field. The method is then applied to a polarizable methanol model, where the CG dieter is able to match the atomistic dipole distribution. Force fields are benchmarked with radial distribution functions and dielectric constants. The static dielectric constants agree well with atomistic models, but the faster dynamics in the CG ensembles leads to significant deviations in the frequency-dependent permittivity. Model transferability is checked by measuring response to static external fields through a dipole coupling order parameter. Effective polarizabilities are inferred from the dimer harmonic bonds, and an ad hoc correction is used to improve one CG force field's dipole magnitude response to electric fields. Broader applicability is explored through a small set of amines, and several multibead models are tested where CG dipole orientations are restricted through intramolecular forces, capturing constructive and destructive dipole interactions within single molecules.
C1 [Lafond, Patrick G.; Izvekov, Sergei] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA.
RP Lafond, PG (reprint author), US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA.
EM patrick.g.lafond.ctr@mail.mil
FU Army Research Laboratory [W911NF-12-2-0019]
FX We thank Jan W. Andzelm and Timothy W. Sirk for their feedback to this
work and insightful discussions. All calculations were performed at the
DOD HPCMP DSRC located at ARL. P.G.L. was sponsored by the Army Research
Laboratory and was accomplished under Cooperative Agreement Number
W911NF-12-2-0019. The views and conclusions contained in this document
are those of the authors and should not be interpreted as representing
the official policies, either expressed or implied, of the Army Research
Laboratory or the U.S. Government. The U.S. Government is authorized to
reproduce and distribute reprints for Government purposes
notwithstanding any copyright notation herein.
NR 66
TC 0
Z9 0
U1 8
U2 8
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1549-9618
EI 1549-9626
J9 J CHEM THEORY COMPUT
JI J. Chem. Theory Comput.
PD DEC
PY 2016
VL 12
IS 12
BP 5737
EP 5750
DI 10.1021/acs.jctc.6b00538
PG 14
WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical
SC Chemistry; Physics
GA EE8HO
UT WOS:000389866500006
PM 27726406
ER
PT J
AU Lieberman, HR
Agarwal, S
Fulgoni, VL
AF Lieberman, Harris R.
Agarwal, Sanjiv
Fulgoni, Victor L., III
TI Tryptophan Intake in the US Adult Population Is Not Related to Liver or
Kidney Function but Is Associated with Depression and Sleep Outcomes
SO JOURNAL OF NUTRITION
LA English
DT Article; Proceedings Paper
CT 9th Workshop on the Assessment of Adequate and Safe Intake of Dietary
Amino Acids at the 9th Amino Acid Assessment Workshop
CY OCT 15-16, 2015
CL Paris, FRANCE
SP Int Council Amino Acid Sci
DE liver function markers; kidney function markers; glucose; insulin; mood;
Patient Health Questionnaire (PHQ-9); serotonin
ID EOSINOPHILIA-MYALGIA-SYNDROME; MOOD; PERFORMANCE; DEPLETION; NUTRITION;
MELATONIN; ILLNESS; TESTS
AB Background: Tryptophan is an indispensable amino acid and is a precursor of the neurotransmitter serotonin. Tryptophan metabolites, such as serotonin and melatonin, are thought to participate in the regulation of mood and sleep and tryptophan is used to treat insomnia, sleep apnea, and depression.
Objective: This study examined the intake of tryptophan and its associations with biochemical, behavioral, sleep, and health and safety outcomes in adults in a secondary analysis of a large, publicly available database of the US population.
Methods: Data from the NHANES 2001-2012 (n = 29,687) were used to determine daily intakes of tryptophan and its associations with biochemical markers of health- and safety-related outcomes, self-reported depression, and sleep-related variables. Data were adjusted for demographic factors and protein intake. Linear trends were computed across deciles of intake for each outcome variable, and P-trends were determined.
Results: The usual tryptophan intake by US adults was 826 mg/d, severalfold higher than the Estimated Average Requirement for adults of 4 mg/(kg . d) (similar to 280 mg/d for a 70-kg adult). Most health- and safety-related biochemical markers of liver function, kidney function, and carbohydrate metabolism were not significantly (P-trend > 0.05) associated with deciles of tryptophan intake and were well within normal ranges, even for individuals in the 99th percentile of intake. Usual intake deciles of tryptophan were inversely associated with self-reported depression measured by the Patient Health Questionnaire raw score (0-27; P-trend < 0.01) and calculated level (1 = no depression, 5 = severe depression; P-trend < 0.01) and were positively associated with self-reported sleep duration (P-trend = 0.02).
Conclusions: Tryptophan intake was not related to most markers of liver function, kidney function or carbohydrate metabolism. Levels of tryptophan intake in the US population appear to be safe as shown by the absence of abnormal laboratory findings. Tryptophan intake was inversely associated with self-reported level of depression and positively associated with sleep duration.
C1 [Lieberman, Harris R.] US Army Res Inst Environm Med, Mil Nutr Div, Natick, MA 01760 USA.
[Agarwal, Sanjiv; Fulgoni, Victor L., III] Oak Ridge Inst Sci & Educ, Belcamp, MD USA.
[Fulgoni, Victor L., III] Henry M Jackson Fdn, Bethesda, MD USA.
RP Lieberman, HR (reprint author), US Army Res Inst Environm Med, Mil Nutr Div, Natick, MA 01760 USA.
EM harriss.lieberman.civ@mail.mil
NR 47
TC 0
Z9 0
U1 2
U2 2
PU AMER SOC NUTRITION-ASN
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-3166
EI 1541-6100
J9 J NUTR
JI J. Nutr.
PD DEC
PY 2016
VL 146
IS 12
BP 2609
EP 2615
DI 10.3945/jn.115.226969
PG 7
WC Nutrition & Dietetics
SC Nutrition & Dietetics
GA EE2CP
UT WOS:000389391600024
PM 27934652
ER
PT J
AU Holfeld, J
Zimpfer, D
Albrecht-Schgoer, K
Stojadinovic, A
Paulus, P
Dumfarth, J
Thomas, A
Lobenwein, D
Tepekoylu, C
Rosenhek, R
Schaden, W
Kirchmair, R
Aharinejad, S
Grimm, M
AF Holfeld, Johannes
Zimpfer, Daniel
Albrecht-Schgoer, Karin
Stojadinovic, Alexander
Paulus, Patrick
Dumfarth, Julia
Thomas, Anita
Lobenwein, Daniela
Tepekoeylue, Can
Rosenhek, Raphael
Schaden, Wolfgang
Kirchmair, Rudolf
Aharinejad, Seyedhossein
Grimm, Michael
TI Epicardial shock-wave therapy improves ventricular function in a porcine
model of ischaemic heart disease
SO JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
LA English
DT Article
DE shockwave therapy; myocardial infarction; left ventricular ejection
fraction; angiogenesis; endothelial cells; vascular endothelial growth
factor
ID MYOCARDIAL VIABILITY ASSESSMENT; SKIN FLAP MODEL; GENE-THERAPY;
ANGIOGENESIS; FAILURE; DYSFUNCTION; CELLS; LIFE; PIGS
AB Previously we have shown that epicardial shock-wave therapy improves left ventricular ejection fraction (LVEF) in a rat model of myocardial infarction. In the present experiments we aimed to address the safety and efficacy of epicardial shock-wave therapy in a preclinical large animal model and to further evaluate mechanisms of action of this novel therapy. Four weeks after left anterior descending (LAD) artery ligation in pigs, the animals underwent re-thoracotomy with (shock-wave group, n=6) or without (control group, n=5) epicardial shock waves (300 impulses at 0.38 mJ/mm(2)) applied to the infarcted anterior wall. Efficacy endpoints were improvement of LVEF and induction of angiogenesis 6 weeks after shock-wave therapy. Safety endpoints were haemodynamic stability during treatment and myocardial damage. Four weeks after LAD ligation, LVEF decreased in both the shock-wave (43 +/- 3%, p<0.001) and control (41 +/- 4%, p=0.012) groups. LVEF markedly improved in shock-wave animals 6 weeks after treatment (62 +/- 9%, p=0.006); no improvement was observed in controls (41 +/- 4%, p=0.36), yielding a significant difference. Quantitative histology revealed significant angiogenesis 6 weeks after treatment (controls 2 +/- 0.4 arterioles/high-power field vs treatment group 9 +/- 3; p=0.004). No acute or chronic adverse effects were observed. As a potential mechanism of action in vitro experiments showed stimulation of VEGF receptors after shock-wave treatment in human coronary artery endothelial cells. Epicardial shock-wave treatment in a large animal model of ischaemic heart failure exerted a positive effect on LVEF improvement and did not show any adverse effects. Angiogenesis was induced by stimulation of VEGF receptors. Copyright (c) 2014 John Wiley & Sons, Ltd.
C1 [Holfeld, Johannes; Dumfarth, Julia; Lobenwein, Daniela; Tepekoeylue, Can; Grimm, Michael] Med Univ Innsbruck, Dept Cardiac Surg, Anichstr 35, A-6020 Innsbruck, Austria.
[Zimpfer, Daniel; Aharinejad, Seyedhossein] Med Univ Vienna, Dept Cardiac Surg, Vienna, Austria.
[Albrecht-Schgoer, Karin] Med Univ Innsbruck, Dept Internal Med 1, Innsbruck, Austria.
[Stojadinovic, Alexander; Kirchmair, Rudolf] Walter Reed Army Med Ctr, Combat Wound Initiat Program, Washington, DC USA.
[Stojadinovic, Alexander; Kirchmair, Rudolf] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
[Paulus, Patrick] Goethe Univ Hosp Frankfurt, Clin Anaesthesiol Intens Care Med & Pain Therapy, Frankfurt, Germany.
[Aharinejad, Seyedhossein] Med Univ Vienna, Dept Anat & Cell Biol, Lab Cardiovasc Res, Vienna, Austria.
[Thomas, Anita] Med Univ Vienna, Dept Internal Med 3, Gender Med Unit, Vienna, Austria.
[Rosenhek, Raphael] Med Univ Vienna, Dept Internal Med 2, Vienna, Austria.
[Schaden, Wolfgang] AUVA Trauma Ctr Meidling, Vienna, Austria.
RP Grimm, M (reprint author), Med Univ Innsbruck, Dept Cardiac Surg, Anichstr 35, A-6020 Innsbruck, Austria.
EM michael.grimm@uki.at
FU Cardiac Regeneration Technologies LLC (CRT), Woodstock, GA, USA; Combat
Wound Initiative Program, Walter Reed Army Medical Center, Washington,
DC
FX This study was supported by a research grant provided by Cardiac
Regeneration Technologies LLC (CRT), Woodstock, GA, USA. This study was
also supported in part by the Combat Wound Initiative Program, Walter
Reed Army Medical Center, Washington, DC. Defocused, low-energy
shock-wave therapy is delivered by the DermaGold (TM) under an
investigational device exemption (IDE, #14) in a Tissue Regeneration
Technologies LLC-sponsored FDA trial, as part of the Combat Wound
Initiative Program. Walter Reed Army Medical Center is one
investigational site for this international multicentre trial led by the
Combat Wound Initiative Program, which is a congressionally funded
program.
NR 26
TC 5
Z9 5
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1932-6254
EI 1932-7005
J9 J TISSUE ENG REGEN M
JI J. Tissue Eng. Regen. Med.
PD DEC
PY 2016
VL 10
IS 12
BP 1057
EP 1064
DI 10.1002/term.1890
PG 8
WC Cell & Tissue Engineering; Biotechnology & Applied Microbiology; Cell
Biology; Engineering, Biomedical
SC Cell Biology; Biotechnology & Applied Microbiology; Engineering
GA EE8XK
UT WOS:000389909800009
PM 24841341
ER
PT J
AU Tarney, CM
Klaric, J
Beltran, T
Pagan, M
Han, J
AF Tarney, Christopher M.
Klaric, John
Beltran, Thomas
Pagan, Megan
Han, Jasmine
TI Prevalence of Human Papillomavirus in Self-Collected Cervicovaginal
Swabs in Young Women in the United States Between 2003 and 2012
SO OBSTETRICS AND GYNECOLOGY
LA English
DT Article
ID HPV TYPES; VACCINE INTRODUCTION; CROSS-PROTECTION; NATIONAL-HEALTH;
INFECTION; REDUCTION; IMPACT
AB OBJECTIVE: To evaluate whether there was a change in prevalence of human papillomavirus (HPV) in the United States correlated with the introduction of HPV vaccines in both vaccinated and unvaccinated women.
METHODS: We performed a retrospective review of prevalence data for women aged 18-29 years living in the United States using the National Health and Nutrition Examination Surveys, which is an ongoing series of cross-sectional surveys. Participants provided responses to standardized questions and self-collected cervicovaginal swabs in which a Linear Array HPV Assay was used to determine HPV prevalence. A total of 783 women from the prevaccine era (2003-2004) and 1,526 from the postvaccine era (2007-2012) were analyzed.
RESULTS: Among women aged 18-29 years, the prevalence of vaccine-type HPV declined among women receiving one or more doses of vaccine (P=.003): 10.1% (95% confidence interval [CI] 7.1-13.8%) in the prevaccine era to 4.2% (95% CI 3.3-10.9%) in the postvaccine era. There was no change in prevalence of nonvaccine-type HPV among women receiving one or more doses of vaccine (P.. 05). There was also no change in prevalence of vaccine-type HPV among unvaccinated women from the prevaccine era 10.1% (95% CI 7.1-13.8%) to 8.8% (95% CI 5.6-12.9%) in the postvaccine era (P=.4). Vaccine coverage increased to 31.5% of eligible women aged 18-29 years as of 2011-2012.
CONCLUSION: Six years after introduction of HPV vaccination in the United States, there has been a decrease in the prevalence of vaccine-type HPV among women correlated with receiving one or more vaccine doses with no change in nonvaccine-type HPV. Furthermore, there has been no change in prevalence of vaccine-type HPV among unvaccinated women.
C1 Womack Army Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol, Ft Bragg, NC USA.
Womack Army Med Ctr, Dept Clin Invest, Ft Bragg, NC USA.
RP Tarney, CM (reprint author), Womack Army Med Ctr, Dept Obstet & Gynecol, 2817 Reilly Rd, Ft Bragg, NC 28307 USA.
EM christopher.m.tarney.mil@mail.mil
NR 15
TC 0
Z9 0
U1 3
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0029-7844
J9 OBSTET GYNECOL
JI Obstet. Gynecol.
PD DEC
PY 2016
VL 128
IS 6
BP 1241
EP 1247
DI 10.1097/AOG.0000000000001760
PG 7
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA EE5KH
UT WOS:000389645200007
PM 27824760
ER
PT J
AU Sheehan, RC
Rabago, CA
Rylander, JH
Dingwell, JB
Wilken, JM
AF Sheehan, Riley C.
Rabago, Christopher A.
Rylander, Jonathan H.
Dingwell, Jonathan B.
Wilken, Jason M.
TI Use of Perturbation-Based Gait Training in a Virtual Environment to
Address Mediolateral Instability in an Individual With Unilateral
Transfemoral Amputation
SO PHYSICAL THERAPY
LA English
DT Article
ID TRANSTIBIAL AMPUTATION; DESTABILIZING ENVIRONMENTS; HUMAN WALKING;
DYNAMIC STABILITY; PROSTHETIC KNEES; C-LEG; LATERAL STABILIZATION;
PREVENTING FALLS; ROCK SURFACE; OLDER-ADULTS
AB Background and Purpose. Roughly 50% of individuals with lower limb amputation report a fear of falling and fall at least once a year. Perturbation-based gait training and the use of virtual environments have been shown independently to be effective at improving walking stability in patient populations. An intervention was developed combining the strengths of the 2 paradigms utilizing continuous, walking surface angle oscillations within a virtual environment. This case report describes walking function and mediolateral stability outcomes of an individual with a unilateral transfemoral amputation following a novel perturbation-based gait training intervention in a virtual environment.
Case Description. The patient was a 43-year-old male veteran who underwent a right transfemoral amputation 7+ years previously as a result of a traumatic blast injury. He used a microprocessor-controlled knee and an energy storage and return foot.
Outcomes. Following the intervention, multiple measures indicated improved function and stability, including faster self-selected walking speed and reduced functional stepping time, mean step width, and step width variability. These changes were seen during normal level walking and mediolateral visual field or platform perturbations. In addition, benefits were retained at least 5 weeks after the final training session.
Discussion. The perturbation-based gait training program in the virtual environment resulted in the patient's improved walking function and mediolateral stability. Although the patient had completed intensive rehabilitation following injury and was fully independent, the intervention still induced notable improvements to mediolateral stability. Thus, perturbation based gait training in challenging simulated environments shows promise for improving walking stability and may be beneficial when integrated into a rehabilitation program.
C1 [Sheehan, Riley C.] Brooke Army Med Ctr, Ctr Intrepid, Mil Performance Lab, JBSA, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
[Rabago, Christopher A.; Wilken, Jason M.] Brooke Army Med Ctr, Ctr Intrepid, Mil Performance Lab, Ft Sam Houston, TX 78234 USA.
[Rabago, Christopher A.; Wilken, Jason M.] JBSA, Extrem Trauma & Amputat Ctr Excellence, Ft Sam Houston, TX USA.
[Rylander, Jonathan H.] Baylor Univ, Dept Mech Engn, Waco, TX 76798 USA.
[Dingwell, Jonathan B.] Univ Texas Austin, Dept Kinesiol & Hlth Educ, Austin, TX 78712 USA.
RP Sheehan, RC (reprint author), Brooke Army Med Ctr, Ctr Intrepid, Mil Performance Lab, JBSA, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
EM riley.c.sheehan.ctr@mail.mil
FU National Institutes of Health [1-R01-HD059844]; DoD/CDMRP/BADER
Consortium [W81XWH-11-2-0222]
FX This work was supported by National Institutes of Health grant
1-R01-HD059844 and DoD/CDMRP/BADER Consortium W81XWH-11-2-0222 (to
J.B.D. and J.M.W.).
NR 42
TC 0
Z9 0
U1 0
U2 0
PU AMER PHYSICAL THERAPY ASSOC
PI ALEXANDRIA
PA 1111 N FAIRFAX ST, ALEXANDRIA, VA 22314 USA
SN 0031-9023
EI 1538-6724
J9 PHYS THER
JI Phys. Ther.
PD DEC
PY 2016
VL 96
IS 12
BP 1896
EP 1904
DI 10.2522/ptj.20150566
PG 9
WC Orthopedics; Rehabilitation
SC Orthopedics; Rehabilitation
GA EE2FM
UT WOS:000389399100006
PM 27277497
ER
PT J
AU Huon, LK
Liu, SYC
Camacho, M
Guilleminault, C
AF Huon, Leh-Kiong
Liu, Stanley Yung-Chuan
Camacho, Macario
Guilleminault, Christian
TI The association between ophthalmologic diseases and obstructive sleep
apnea: a systematic review and meta-analysis
SO SLEEP AND BREATHING
LA English
DT Review
DE Obstructive sleep apnea; Glaucoma; Floppy eyelids; Nonarteritic anterior
ischemic optic neuropathy; Central serous chorioretinopathy
ID ISCHEMIC OPTIC NEUROPATHY; CENTRAL SEROUS CHORIORETINOPATHY; FLOPPY
EYELID SYNDROME; NORMAL-TENSION GLAUCOMA; RETINAL VEIN OCCLUSION; FIBER
LAYER THICKNESS; HYPOPNEA SYNDROME; CEREBRAL AUTOREGULATION; COHERENCE
TOMOGRAPHY; SYNDROME OSAS
AB The purpose of this study was to evaluate the association between obstructive sleep apnea (OSA) and ophthalmologic diseases, specifically glaucoma, nonarteritic anterior ischemic optic neuropathy (NAION), retinal vein occlusion (RVO), central serous chorioretinopathy (CSR), and floppy eyelid syndrome (FES), by performing a systematic review and meta-analysis of published studies.
PubMed, Embase, and Scopus databases were searched for observational studies on OSA and its association with select ophthalmologic diseases. Data was pooled for random-effects modeling. The association between OSA and ophthalmologic diseases was summarized using an estimated pooled odds ratio with a 95 % confidence interval.
Relative to non-OSA subjects, OSA subjects have increased odds of diagnosis with glaucoma (pooled odds ratio (OR) = 1.242; P < 0.001) and floppy eyelids syndrome (pooled OR = 4.157; P < 0.001). In reverse, the overall pooled OR for OSA was 1.746 (P = 0.002) in the glaucoma group, 3.126 (P = 0.000) in the NAION group, and 2.019 (P = 0.028) in the CSR group. For RVO, one study with 5965 OSA patients and 29,669 controls demonstrated a 1.94-fold odds increase in OSA patients.
Our results suggest significant associations between OSA and glaucoma, NAION, CSR, and FES. Screening for OSA should be considered in patients with glaucoma, NAION, CSR, or FES.
C1 [Huon, Leh-Kiong] Cathay Gen Hosp, Dept Otolaryngol Head & Neck Surg, Taipei, Taiwan.
[Huon, Leh-Kiong] Fu Jen Catholic Univ, Sch Med, Taipei, Taiwan.
[Huon, Leh-Kiong; Camacho, Macario; Guilleminault, Christian] Stanford Univ, Med Ctr, Div Sleep Med, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA.
[Huon, Leh-Kiong; Liu, Stanley Yung-Chuan; Camacho, Macario] Stanford Univ, Med Ctr, Dept Otolaryngol Head Neck Surg, Div Sleep Surg, Stanford, CA 94305 USA.
[Camacho, Macario] Tripler Army Med Ctr, Div Sleep Surg & Med, Otolaryngol Head & Neck Surg, Honolulu, HI 96859 USA.
[Guilleminault, Christian] Stanford Univ, Sleep Med Div, 450 Broadway St,MC 5704, Redwood City, CA 94063 USA.
RP Guilleminault, C (reprint author), Stanford Univ, Med Ctr, Div Sleep Med, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA.; Guilleminault, C (reprint author), Stanford Univ, Sleep Med Div, 450 Broadway St,MC 5704, Redwood City, CA 94063 USA.
EM cguil@stanford.edu
NR 63
TC 0
Z9 0
U1 3
U2 3
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1520-9512
EI 1522-1709
J9 SLEEP BREATH
JI Sleep Breath.
PD DEC
PY 2016
VL 20
IS 4
BP 1145
EP 1154
DI 10.1007/s11325-016-1358-4
PG 10
WC Clinical Neurology; Respiratory System
SC Neurosciences & Neurology; Respiratory System
GA EF1DM
UT WOS:000390065300003
PM 27230013
ER
PT J
AU Bear, R
Sanders, M
Pompili, J
Stucky, L
Walters, A
Simmons, J
Lacanilao, P
Eagle, S
Grier, T
DeGroot, MAJD
Lovalekar, MT
Nindl, BC
Kane, CSF
Depenbrock, LTCP
AF Bear, Ray
Sanders, Mike
Pompili, Jason
Stucky, Lance
Walters, Andrew
Simmons, Jerry
Lacanilao, Paul
Eagle, Shawn
Grier, Tyson
DeGroot, M. A. J. David
Lovalekar, Mita T.
Nindl, Bradley C.
Kane, Col. Shawn F.
Depenbrock, L. T. C. Patrick
TI Development of the Tactical Human Optimization, Rapid Rehabilitation,
and Reconditioning Program Military Operator Readiness Assessment for
the Special Forces Operator
SO STRENGTH AND CONDITIONING JOURNAL
LA English
DT Article
DE return-to-duty test; functional fitness; Special Forces; readiness;
THOR3
ID PHYSICAL PERFORMANCE; RISK-FACTORS; MUSCULOSKELETAL INJURIES; ARMY;
COMBAT; SOLDIERS; CONSEQUENCES; EPIDEMIOLOGY; AFGHANISTAN; STRENGTH
AB The aim of this article is to describe a novel military unique Operator Readiness Assessment (ORA). Theora was designed by tactical human optimization, rapid rehabilitation, and reconditioning professionals as part of a return-to-duty protocol to specifically evaluate the musculoskeletal readiness and physiological preparedness of previously injured operators. The ORA comprises 11 tactically relevant and physically taxing events completed in order with a 2-minute rest between events. Development of a comprehensive return-to-duty protocol of this nature is a necessary first step for tactical strength coaches to reduce risk of reinjury to previously injured personnel.
C1 [Bear, Ray; Sanders, Mike; Pompili, Jason; Stucky, Lance; Walters, Andrew; Simmons, Jerry; Lacanilao, Paul; Kane, Col. Shawn F.; Depenbrock, L. T. C. Patrick] US Army, Tact Human Optimizat Rapid Rehabil & Reconditioni, Special Operat Command, Ft Bragg, Ft Bragg, NC USA.
[Eagle, Shawn] Univ Pittsburgh, Sch Hlth & Rehabil Sci, Dept Sports Med & Nutr, Neuromuscular Res Lab,Warrior Human Performance R, Pittsburgh, PA 15260 USA.
[Grier, Tyson; DeGroot, M. A. J. David] Army Publ Hlth Ctr Provis, Injury Prevent Div, Clin Publ Hlth & Epidemiol Directorate, Aberdeen, MD USA.
RP Eagle, S (reprint author), Univ Pittsburgh, Sch Hlth & Rehabil Sci, Dept Sports Med & Nutr, Neuromuscular Res Lab,Warrior Human Performance R, Pittsburgh, PA 15260 USA.
EM seagle@pitt.edu
NR 23
TC 0
Z9 0
U1 3
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1524-1602
EI 1533-4295
J9 STRENGTH COND J
JI Strength Cond. J.
PD DEC
PY 2016
VL 38
IS 6
BP 55
EP 60
DI 10.1519/SSC.0000000000000258
PG 6
WC Sport Sciences
SC Sport Sciences
GA EE0DP
UT WOS:000389244200006
ER
PT J
AU Stegelmeier, BL
Colegate, SM
Brown, AW
AF Stegelmeier, Bryan L.
Colegate, Steven M.
Brown, Ammon W.
TI Dehydropyrrolizidine Alkaloid Toxicity, Cytotoxicity, and
Carcinogenicity
SO TOXINS
LA English
DT Review
DE dehydropyrrolizidine; DHPA; pyrrolizidine; alkaloids; PA; toxic plant;
pyrrolizidine alkaloid-induced cytotoxicity; toxic hepatopathy;
carcinogenesis
ID PYRROLIZIDINE ALKALOIDS; DNA-ADDUCTS; VENOOCCLUSIVE DISEASE; IN-VITRO;
N-OXIDES; S-PHASE; RIDDELLIINE; RATS; METABOLITES; PLANTS
AB Dehydropyrrolizidine alkaloid (DHPA)-producing plants have a worldwide distribution amongst flowering plants and commonly cause poisoning of livestock, wildlife, and humans. Previous work has produced considerable understanding of DHPA metabolism, toxicity, species susceptibility, conditions, and routes of exposure, and pathogenesis of acute poisoning. Intoxication is generally caused by contaminated grains, feed, flour, and breads that result in acute, high-dose, short-duration poisoning. Acute poisoning produces hepatic necrosis that is usually confirmed histologically, epidemiologically, and chemically. Less is known about chronic poisoning that may result when plant populations are sporadic, used as tisanes or herbal preparations, or when DHPAs contaminate milk, honey, pollen, or other animal-derived products. Such subclinical exposures may contribute to the development of chronic disease in humans or may be cumulative and probably slowly progress until liver failure. Recent work using rodent models suggest increased neoplastic incidence even with very low DHPA doses of short durations. These concerns have moved some governments to prohibit or limit human exposure to DHPAs. The purpose of this review is to summarize some recent DHPA research, including in vitro and in vivo DHPA toxicity and carcinogenicity reports, and the implications of these findings with respect to diagnosis and prognosis for human and animal health.
C1 [Stegelmeier, Bryan L.; Colegate, Steven M.] ARS, USDA, Poisonous Plant Res Lab, 1150 East 1400 North, Logan, UT 84341 USA.
[Colegate, Steven M.] Utah State Univ, Dept Anim Dairy & Vet Sci, Logan, UT 84322 USA.
[Brown, Ammon W.] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
RP Stegelmeier, BL (reprint author), ARS, USDA, Poisonous Plant Res Lab, 1150 East 1400 North, Logan, UT 84341 USA.
EM bryan.stegelmeier@ars.usda.gov; steven.colegate@usu.edu;
brown.ammon@gmail.com
NR 60
TC 0
Z9 0
U1 7
U2 7
PU MDPI AG
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 2072-6651
J9 TOXINS
JI Toxins
PD DEC
PY 2016
VL 8
IS 12
DI 10.3390/toxins8120356
PG 15
WC Toxicology
SC Toxicology
GA EE1LC
UT WOS:000389342000010
ER
PT J
AU Shakarian, P
Simari, GI
Moores, G
Paulo, D
Parsons, S
Falappa, MA
Aleali, A
AF Shakarian, Paulo
Simari, Gerardo I.
Moores, Geoffrey
Paulo, Damon
Parsons, Simon
Falappa, Marcelo A.
Aleali, Ashkan
TI Belief revision in structured probabilistic argumentation Model and
application to cyber security
SO ANNALS OF MATHEMATICS AND ARTIFICIAL INTELLIGENCE
LA English
DT Article
DE Argumentation; Belief revision; Probabilistic reasoning; Cyber security
ID LOGIC PROGRAMS; CONTRACTION
AB In real-world applications, knowledge bases consisting of all the available information for a specific domain, along with the current state of affairs, will typically contain contradictory data, coming from different sources, as well as data with varying degrees of uncertainty attached. An important aspect of the effort associated with maintaining such knowledge bases is deciding what information is no longer useful; pieces of information may be outdated; may come from sources that have recently been discovered to be of low quality; or abundant evidence may be available that contradicts them. In this paper, we propose a probabilistic structured argumentation framework that arises from the extension of Presumptive Defeasible Logic Programming (PreDeLP) with probabilistic models, and argue that this formalism is capable of addressing these basic issues. The formalism is capable of handling contradictory and uncertain data, and we study non-prioritized belief revision over probabilistic PreDeLP programs that can help with knowledge-base maintenance. For belief revision, we propose a set of rationality postulates-based on well-known ones developed for classical knowledge bases-that characterize how these belief revision operations should behave, and study classes of operators along with theoretical relationships with the proposed postulates, including representation theorems stating the equivalence between classes of operators and their associated postulates. We then demonstrate how our framework can be used to address the attribution problem in cyber security/cyber warfare.
C1 [Shakarian, Paulo; Aleali, Ashkan] Arizona State Univ, Tempe, AZ 85281 USA.
[Simari, Gerardo I.; Falappa, Marcelo A.] Univ Nacl Sur, Dept Comp Sci & Engn, Bahia Blanca, Buenos Aires, Argentina.
[Simari, Gerardo I.; Falappa, Marcelo A.] UNS, CONICET, Inst Comp Sci & Engn, Bahia Blanca, Buenos Aires, Argentina.
[Moores, Geoffrey; Paulo, Damon] US Mil Acad, Dept Elect Engn & Comp Sci, West Point, NY USA.
[Parsons, Simon] Univ Liverpool, Dept Comp Sci, Liverpool, Merseyside, England.
RP Shakarian, P (reprint author), Arizona State Univ, Tempe, AZ 85281 USA.
EM shak@asu.edu; gis@cs.uns.edu.ar; geoffrey.moores@usma.edu;
damon.paulo@usma.edu; s.d.parsons@liverpool.ac.uk;
mfalappa@cs.uns.edu.ar; aleali@asu.edu
OI Simari, Gerardo/0000-0003-3185-4992
FU UK EPSRC [EP/J008346/1]; ERC [246858]; CONICET; Universidad Nacional del
Sur, Argentina; NSF [1117761]; Army Research Office; DARPA
[R.0004972.001]; [2GDATXR042]
FX This work was supported by UK EPSRC grant EP/J008346/1-"PrOQAW", by ERC
grant 246858-"DIADEM", funds provided by CONICET and Universidad
Nacional del Sur, Argentina, by NSF grant #1117761, by the Army Research
Office under the Science of Security Lablet grant (SoSL) and project
2GDATXR042, and DARPA project R.0004972.001. The opinions in this paper
are those of the authors and do not necessarily reflect the opinions of
the funders, the U.S. Military Academy, or the U.S. Army.
NR 47
TC 1
Z9 1
U1 1
U2 1
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1012-2443
EI 1573-7470
J9 ANN MATH ARTIF INTEL
JI Ann. Math. Artif. Intell.
PD DEC
PY 2016
VL 78
IS 3-4
BP 259
EP 301
DI 10.1007/s10472-015-9483-5
PG 43
WC Computer Science, Artificial Intelligence; Mathematics, Applied
SC Computer Science; Mathematics
GA ED4VY
UT WOS:000388851200004
ER
PT J
AU Gray, JB
Sorrie, BA
Wall, W
AF Gray, Janet Bracey
Sorrie, Bruce A.
Wall, Wade
TI Canebrakes of the Sandhills Region of the Carolinas and Georgia: Fire
History, Canebrake Area, and Species Frequency
SO CASTANEA
LA English
DT Article
DE Arundinaria tecta; canebrakes; fire frequency; fire-return interval;
rare flora; switch cane; vascular plants
ID SOUTH-CAROLINA; COASTAL-PLAIN; VEGETATION; SIZE
AB Canebrakes formerly occupied hundreds of thousands of hectares across the southeastern USA, but habitat conversion and fire suppression have reduced their size and extent. Currently, canebrakes are among the rarest vegetative communities in the southeastern USA. Research has focused on Arundinaria gigantea (river cane), with very little focus on Arundinaria tecta (switch cane). The fire history, area, associated flora, and species frequency of 13 canebrakes, dominated by switch cane, were examined at three Department of the Army locations and one game land in the Sandhills physiographic region. We determined canebrake area by identifying its unique vegetative signature in aerial photography at three time steps: earliest aerial photography, the beginning of the recorded burn history, and current aerial photography. We compared fire-return intervals to changes in canebrake area. We created a checklist and tallied 330 taxa of vascular plants (plus Sphagnum sp.) from the 13 canebrakes in our study and calculated species frequency. Estimated area of the 13 observed canebrakes has increased from 25.6 ha historically to 592.8 ha. Mean fire-return interval is within a range of 1-2.3 yr. As fire-return intervals decrease, canebrake area increases, but that increase starts to decline after 2 yr. The highest number of taxa recorded for individual canebrakes were found on Fort Jackson, South Carolina, at Buffalo Creek (236 species) and Fort Bragg, North Carolina, at Black Creek (201 species). Species frequency demonstrates that canebrakes are capable of supporting a mix of herbaceous, shrubby, and arboreal species, which includes rare taxa.
C1 [Gray, Janet Bracey] IMBG DPW E, Endangered Species Branch, Ft Bragg, NC 28310 USA.
[Sorrie, Bruce A.] Univ North Carolina Herbarium, North Carolina Bot Garden, Chapel Hill, NC 27599 USA.
[Wall, Wade] US Army, Engineer Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61826 USA.
RP Gray, JB (reprint author), IMBG DPW E, Endangered Species Branch, Ft Bragg, NC 28310 USA.
EM Janet.b.gray.civ@mail.mil
FU Department of the Army; Department of Public Works; Endangered Species
Branch, Fort Bragg
FX This study was made possible with the support of the Department of the
Army, Department of Public Works, and the Endangered Species Branch,
Fort Bragg. Special thanks to Brady Beck, North Carolina Wildlife
Resources Commission, for supplying the fire history data for the
Sandhills Game Land. This article would not possible without the help
from the following staff at Fort Jackson: Nicole Hawkins (Wildlife
Biologist), Douglas M. Morrow (Chief, Wildlife Branch), and Doug Mayes,
GIS support, Master Planning for providing fire history data and aerial
photography. Much appreciation to Caleb Garrett, GIS Forester, Land
Management Branch at Fort Benning for fire history data and aerial
photography. The following people provided photographs of canebrakes:
J.B.G. and B.A.S., Brian Ball, and Nick Haddad. J.B.G. is appreciative
of her long-time colleague, Erich Hoffman, for assisting in the
verification of the canebrake areas. This article is dedicated
respectfully, to J.B.G.'s son, Zachary Mills Shipley.
NR 35
TC 0
Z9 0
U1 5
U2 5
PU SOUTHERN APPALACHIAN BOTANICAL SOC, NEWBERRY COLL
PI NEWBERRY
PA DEPT BIOLOGY, C/O CHARLES N HORN, SECRETARY-TREASURER, 2100 COLLEGE ST,
NEWBERRY, SC 29108 USA
SN 0008-7475
EI 1938-4386
J9 CASTANEA
JI Castanea
PD DEC
PY 2016
VL 81
IS 4
BP 280
EP 291
DI 10.2179/16-112
PG 12
WC Plant Sciences
SC Plant Sciences
GA EE1DD
UT WOS:000389320100004
ER
PT J
AU Sharaiha, RZ
Tyberg, A
Khashab, MA
Kumta, NA
Karia, K
Nieto, J
Siddiqui, UD
Waxman, I
Joshi, V
Benias, PC
Darwin, P
DiMaio, CJ
Mulder, CJ
Friedland, S
Forcione, DG
Sejpal, DV
Gonda, TA
Gress, FG
Gaidhane, M
Koons, A
DeFilippis, EM
Salgado, S
Weaver, KR
Poneros, JM
Sethi, A
Ho, S
Kumbhari, V
Singh, VK
Tieu, AH
Parra, V
Likhitsup, A
Womeldorph, C
Casey, B
Jonnalagadda, SS
Desai, AP
Carr-Locke, DL
Kahaleh, M
Siddiqui, AA
AF Sharaiha, Reem Z.
Tyberg, Amy
Khashab, Mouen A.
Kumta, Nikhil A.
Karia, Kunal
Nieto, Jose
Siddiqui, Uzma D.
Waxman, Irving
Joshi, Virendra
Benias, Petros C.
Darwin, Peter
DiMaio, Christopher J.
Mulder, Christopher J.
Friedland, Shai
Forcione, David G.
Sejpal, Divyesh V.
Gonda, Tamas A.
Gress, Frank G.
Gaidhane, Monica
Koons, Ann
DeFilippis, Ersilia M.
Salgado, Sanjay
Weaver, Kristen R.
Poneros, John M.
Sethi, Amrita
Ho, Sammy
Kumbhari, Vivek
Singh, Vikesh K.
Tieu, Alan H.
Parra, Viviana
Likhitsup, Alisa
Womeldorph, Craig
Casey, Brenna
Jonnalagadda, Sreeni S.
Desai, Amit P.
Carr-Locke, David L.
Kahaleh, Michel
Siddiqui, Ali A.
TI Endoscopic Therapy With Lumen-apposing Metal Stents Is Safe and
Effective for Patients With Pancreatic Walled-off Necrosis
SO Clinical Gastroenterology and Hepatology
LA English
DT Article
DE ERCP; Pancreatic Necrosis; Pancreatitis; Stents; Necrosectomy
ID PERIPANCREATIC FLUID COLLECTIONS; ULTRASOUND-GUIDED DRAINAGE; REPORTING
RISK-FACTORS; NECROTIZING PANCREATITIS; ADVERSE EVENTS; NECROSECTOMY;
EXPERIENCE
AB BACKGROUND & AIMS: Endoscopic ultrasound-guided transmural drainage and necrosectomy have become the standard treatment for patients with pancreatic walled-off necrosis (WON). Lumen-apposing metal stents (LAMS) have shown success in the management of pancreatic fluid collections. However, there are few data on their specific roles in management of WON. We investigated the efficacy and safety of LAMS in treatment of WON.
METHODS: We performed a retrospective multicenter case series of 124 patients with WON who underwent endoscopic transmural drainage by using LAMS at 17 tertiary care centers from January 2014 through May 2015. Patients underwent endoscopic ultrasound-guided cystogastrostomy or cystoenterostomy with placement of an LAMS into the WON collection. At the discretion of the endoscopist, we performed direct endoscopic necrosectomy, irrigation with hydrogen peroxide, and/or nasocystic drain placement. We performed endoscopic retrograde cholangiopancreatography with pancreatic duct stent placement when indicated. Concomitant therapies included direct endoscopic debridement (n = 78), pancreatic duct stent placement for leak (n = 19), hydrogen peroxide-assisted necrosectomy (n = 38), and nasocystic irrigation (n = 22). We collected data for a median time of 4 months (range, 1-34 months) after the LAMS placement. The primary outcomes were rates of technical success (successful placement of the LAMS), clinical success (resolution of WON, on the basis of image analysis, without need for further intervention via surgery or interventional radiology), and adverse events.
RESULTS: The median size of the WON was 9.5 cm (range, 4-30 cm). Eight patients had 2 LAMS placed for multiport access, all with technical success (100%). Clinical success was achieved in 107 patients (86.3%) after 3 months of follow-up. Thirteen patients required a percutaneous drain, and 3 required a surgical intervention to manage their WON. The stents remained patent in 94% of patients (117 of 124) and migrated in 5.6% of patients (7 of 124). The median number of endoscopic interventions was 2 (range, 1-9 interventions).
CONCLUSIONS: On the basis of a retrospective analysis of 124 patients, endoscopic therapy of WON by using LAMS is safe and effective. Creation of a large and sustained cystogastrostomy or cystoenterostomy tract is effective in the drainage and treatment of WON.
C1 [Sharaiha, Reem Z.; Tyberg, Amy; Kumta, Nikhil A.; Karia, Kunal; Gaidhane, Monica; DeFilippis, Ersilia M.; Salgado, Sanjay; Weaver, Kristen R.; Parra, Viviana; Desai, Amit P.; Kahaleh, Michel] Weill Cornell Med Ctr, Gastroenterol & Hepatol, New York, NY USA.
[Khashab, Mouen A.; Kumbhari, Vivek; Singh, Vikesh K.; Tieu, Alan H.] Johns Hopkins Med Inst, Gastroenterol & Hepatol, Baltimore, MD 21205 USA.
[Siddiqui, Uzma D.; Waxman, Irving; Koons, Ann] Univ Chicago Med & Biol Sci, CERT, Chicago, IL USA.
[Gonda, Tamas A.; Gress, Frank G.; Poneros, John M.; Sethi, Amrita] Columbia Univ, Med Ctr, Gastroenterol & Hepatol, New York, NY USA.
[Friedland, Shai] Stanford Hosp & Clin, Gastroenterol & Hepatol, Palo Alto, CA USA.
[Joshi, Virendra] Ochsner Hlth Syst, Gastroenterol & Hepatol, New Orleans, LA USA.
[Benias, Petros C.; Carr-Locke, David L.] Beth Israel Mt Sinai, Gastroenterol & Hepatol, New York, NY USA.
[Darwin, Peter] Univ Maryland, Gastroenterol & Hepatol, Baltimore, MD 21201 USA.
[Siddiqui, Ali A.] Jefferson Univ, Gastroenterol & Hepatol, Philadelphia, PA USA.
[DiMaio, Christopher J.] Mt Sinai Med Ctr, Gastroenterol & Hepatol, New York, NY 10029 USA.
[Ho, Sammy] Montefiore, Gastroenterol & Hepatol, New York, NY USA.
[Forcione, David G.; Casey, Brenna] Harvard Med Sch, Massachusetts Gen Hosp, Gastroenterol & Hepatol, Boston, MA USA.
[Mulder, Christopher J.; Womeldorph, Craig] Brooke Army Med Ctr, Gastroenterol & Hepatol, Ft Sam Houston, TX 78234 USA.
[Sejpal, Divyesh V.] North Shore Long Isl Jewish Hlth Syst, Gastroenterol & Hepatol, New York, NY USA.
[Likhitsup, Alisa; Jonnalagadda, Sreeni S.] Univ Missouri Kansas City, Gastroenterol & Hepatol, Kansas City, MO USA.
[Nieto, Jose] Borland Groover Clin, Dept Gastroenterol & Hepatol, Jacksonville, FL USA.
RP Sharaiha, RZ (reprint author), Weill Cornell Med Coll, Div Gastroenterol & Hepatol, 1305 York Ave,Fourth Floor, New York, NY 10021 USA.
EM rzs9001@med.cornell.edu
OI Nieto, Jose/0000-0003-2465-3033; Gaidhane, Monica/0000-0001-6773-7080
FU Boston Scientific; Xlumena
FX These authors disclose the following: Mouen A. Khashab, Michel Kahaleh,
David L. Carr-Locke, and Jose Nieto have received financial support from
Boston Scientific and Xlumena. The remaining authors disclose no
conflicts.
NR 21
TC 2
Z9 2
U1 1
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1542-3565
EI 1542-7714
J9 CLIN GASTROENTEROL H
JI Clin. Gastroenterol. Hepatol.
PD DEC
PY 2016
VL 14
IS 12
BP 1797
EP 1803
DI 10.1016/j.cgh.2016.05.011
PG 7
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA EE0QD
UT WOS:000389283100019
PM 27189914
ER
PT J
AU Ahmadisharaf, E
Kalyanapu, AJ
Thames, BA
Lillywhite, J
AF Ahmadisharaf, Ebrahim
Kalyanapu, Alfred J.
Thames, Brantley A.
Lillywhite, Jason
TI A probabilistic framework for comparison of dam breach parameters and
outflow hydrograph generated by different empirical prediction methods
SO ENVIRONMENTAL MODELLING & SOFTWARE
LA English
DT Article
DE Probabilistic dam breach model; Dam breach prediction; Uncertainty
analysis; Multivariate analysis
ID DECISION-SUPPORT-SYSTEM; MODEL CALIBRATION; FLOOD MANAGEMENT;
CLIMATE-CHANGE; UNCERTAINTY; RISK; EFFICIENCY
AB This study presents a probabilistic framework to simulate dam breach and evaluates the impact of using four empirical dam breach prediction methods on breach parameters (i.e., geometry and timing) and outflow hydrograph attributes (i.e., time to peak, hydrograph duration and peak). The methods that are assessed here include MacDonald and Langridge-Monopolis (1984), Von Thun and Gillette (1990), Froehlich (1995), 2008). Mean values and percentiles of breach parameters and outflow hydrograph attributes are compared for hypothetical overtopping failure of Burnett Dam in the state of North Carolina, USA. Furthermore, utilizing the probabilistic framework, the least and most uncertain methods alongside those giving the most critical value are identified for these parameters. The multivariate analysis also indicates that lone use of breach parameters is not necessarily sufficient to characterize outflow hydrograph attributes. However, timing characteristic of the breach is generally a more important driver than its geometric features. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Ahmadisharaf, Ebrahim] Virginia Tech, Dept Biol Syst Engn, Blacksburg, VA 24061 USA.
[Kalyanapu, Alfred J.] Tennessee Technol Univ, Dept Civil & Environm Engn, 1020 Stadium Dr,Box 5015, Cookeville, TN 38505 USA.
[Thames, Brantley A.] US Army Corps Engineers, 801 Broadway, Nashville, TN 37203 USA.
[Lillywhite, Jason] GoldSim Technol Grp, 22500 SE 64th Pl,Suite 240, Issaquah, WA 98027 USA.
RP Kalyanapu, AJ (reprint author), Tennessee Technol Univ, Dept Civil & Environm Engn, 1020 Stadium Dr,Box 5015, Cookeville, TN 38505 USA.
EM akalyanapu@tntech.edu
OI Ahmadisharaf, Ebrahim/0000-0002-9452-7975
FU Center of Management, Utilization and Protection of Water Resources at
the Tennessee Technological University
FX We are grateful to the financial support by Center of Management,
Utilization and Protection of Water Resources at the Tennessee
Technological University. We would also really appreciate the fruitful
guidance by William Flower and Nick Martin for helping in development of
the dam breach model within GoldSim (R) environment. Likewise, we truly
thank Karl Visser for providing insightful information about the
USDA-ARS laboratory test. Special thanks to Michael Gee for providing
data and also valuable guidance on the paper.
NR 74
TC 0
Z9 0
U1 7
U2 7
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1364-8152
EI 1873-6726
J9 ENVIRON MODELL SOFTW
JI Environ. Modell. Softw.
PD DEC
PY 2016
VL 86
BP 248
EP 263
DI 10.1016/j.envsoft.2016.09.022
PG 16
WC Computer Science, Interdisciplinary Applications; Engineering,
Environmental; Environmental Sciences
SC Computer Science; Engineering; Environmental Sciences & Ecology
GA ED3WQ
UT WOS:000388779600019
ER
PT J
AU Vreeland, TJ
Clifton, GT
Herbert, GS
Hale, DF
Jackson, DO
Berry, JS
Peoples, GE
AF Vreeland, T. J.
Clifton, G. T.
Herbert, G. S.
Hale, D. F.
Jackson, D. O.
Berry, J. S.
Peoples, G. E.
TI Gaining ground on a cure through synergy: combining checkpoint
inhibitors with cancer vaccines
SO Expert Review of Clinical Immunology
LA English
DT Review
DE Checkpoint inhibitor; cancer vaccine; PD-1; PD-L1; CTLA-4;
tumor-infiltrating lymphocytes; tumor microenvironment; cancer
immunotherapy; TLPLDC vaccine; melanoma
ID PRETREATED ADVANCED MELANOMA; PROSTATE-CANCER; METASTATIC MELANOMA;
UNTREATED MELANOMA; PANCREATIC-CANCER; T-CELLS; IMMUNOTHERAPY;
IPILIMUMAB; TUMORS; COMBINATION
AB Introduction: The approval of multiple checkpoint inhibitors (CPIs) for the treatment of advanced malignancies has sparked an explosion of research in the field of cancer immunotherapy. Despite the success of these medications, a large number of patients with advanced malignancy do not benefit from therapy. Early research indicates that a therapeutic combination of cancer vaccines with checkpoint inhibitors may lead to synergistic effects and higher response rates than monotherapy.Areas covered: This paper summarizes the previously completed and ongoing research on this exciting combination, including the use of the tumor lysate, particle-loaded dendritic cell (TLPLDC) vaccine combined with checkpoint inhibitors in advanced melanoma.Expert commentary: Increasing experience with CPIs has led to improved understanding of which patients may benefit and it is increasingly clear that the presence of a pre-existing immune response to the tumor, along with tumor-infiltrating lymphocytes, is key to the success of CPIs. One exciting possibility for the future is the addition of a cancer vaccine to CPI therapy, eliciting these crucial T cells, which can then be augmented and protected by the CPI. A number of current and future studies are addressing this very exciting combination therapy.
C1 [Vreeland, T. J.] Womack Army Med Ctr, Dept Surg, Ft Bragg, NC USA.
[Clifton, G. T.; Peoples, G. E.] Univ Texas MD Anderson Canc Ctr, Dept Surg Oncol, Houston, TX 77030 USA.
[Herbert, G. S.; Hale, D. F.; Jackson, D. O.; Berry, J. S.] Brooke Army Med Ctr, Dept Surg, Ft Sam Houston, TX 78234 USA.
[Peoples, G. E.] Canc Vaccine Dev Program, Bethesda, MD USA.
[Peoples, G. E.] Uniformed Serv Univ Hlth Sci, Dept Surg, Bethesda, MD 20814 USA.
RP Vreeland, TJ; Peoples, GE (reprint author), 135 Baystone Dr, Sanford, NC 27332 USA.
EM timothy.j.vreeland.mil@mail.mil; georgepeoples2@hotmail.com
NR 35
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U1 5
U2 5
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1744-666X
EI 1744-8409
J9 EXPERT REV CLIN IMMU
JI Expert Rev. Clin. Immunol.
PD DEC
PY 2016
VL 12
IS 12
BP 1347
EP 1357
DI 10.1080/1744666X.2016.1202114
PG 11
WC Immunology
SC Immunology
GA ED6JM
UT WOS:000388961900009
PM 27323245
ER
PT J
AU Wu, CC
Zheng, XJ
Yang, Q
Yan, YK
Sanghadasa, M
Priya, S
AF Wu, Congcong
Zheng, Xiaojia
Yang, Qiang
Yan, Yongke
Sanghadasa, Mohan
Priya, Shashank
TI Crystallization of HC(NH2)(2)PbI3 Black Polymorph by Solvent
Intercalation for Low Temperature Solution Processing of Perovskite
Solar Cells
SO Journal of Physical Chemistry C
LA English
DT Article
ID FORMAMIDINIUM LEAD IODIDE; J-V HYSTERESIS; HIGH-PERFORMANCE;
SINGLE-CRYSTALS; OPTICAL-PROPERTIES; PBI2; STRAIN; PHASE; RAMAN;
PARAMETERS
AB One of the critical problems in fabrication of flexible perovskite modules and resolving their reliability issue remains the necessity to utilize high temperature annealing for synthesis of perovskite and electron transport layers. Here, we provide a breakthrough in addressing these challenges by demonstrating low temperature synthesis of both of these layers. HC(NH)(2)PbI3 (commonly known as FAPbI(3)) has two polymorphs, a high temperature-stable black FAPbI(3) perovskite-type pseudocubic polymorph (alpha-phase) and a low temperature-stable yellow non-perovskite hexagonal polymorph (delta-phase). In order to understand the crystallization kinetics of the FAPbI(3) black polymorph, a PbI2-NMP complex is fabricated via solvent intercalation between the adjacent I-Pb-I layers. Utilizing structural, electrical, and thermal analyses, the connection between solvent intercalation and the crystallization of the FAPbI(3) black polymorph is established. It is found that the solvent intercalation in the PbI2 crystal causes lattice strain and the induced strain energy could reduce the activation barrier of the intermediate state and favor the crystallization of the FAPbI3 black polymorph. The TiO2 compact layer with a smooth surface, high crystallinity, and superior electron transport is also fabricated at room temperature by using a TiO2 slurry composed of volatile solvents and TiO2 nanoparticles. Using low temperature solution processed TiO2 as electron transport layer, the FAPbI(3)-based perovskite solar cell exhibits a conversion efficiency of 13.2% with significantly reduced hysteresis effect, benefiting from the low electron and hole trap state density. The low temperature process developed in this study holds great promise for flexible perovskite solar cells and perovskite tandem solar cells.
C1 [Wu, Congcong; Zheng, Xiaojia; Yang, Qiang; Yan, Yongke; Priya, Shashank] Virginia Tech, CEHMS, Blacksburg, VA 24061 USA.
[Sanghadasa, Mohan] US Army, Aviat & Missile Res, Ctr Dev & Engn, RDECOM, Redstone Arsenal, AL USA.
RP Wu, CC; Zheng, XJ; Priya, S (reprint author), Virginia Tech, CEHMS, Blacksburg, VA 24061 USA.
EM ccw39@vt.edu; xiaojia@vt.edu; spriya@vt.edu
RI Yang, Qiang/G-8543-2014
OI Yang, Qiang/0000-0001-6720-8795
FU Institute of Critical Technology and Applied Science (ICTAS); Office of
Naval Research through the MURI program; Office of Naval Research
participation in NSF I/UCRC: Center for Energy Harvesting Materials and
Systems (CEHMS)
FX The authors acknowledge the financial support from the Institute of
Critical Technology and Applied Science (ICTAS). Authors S.P. and Q.Y.
would like to acknowledge the financial support from the Office of Naval
Research through the MURI program. Y.Y. was supported through the Office
of Naval Research participation in NSF I/UCRC: Center for Energy
Harvesting Materials and Systems (CEHMS). The authors thank Dr. Bob
Bodnar and Charles Farley, Department of Geosciences, Virginia Tech, for
Raman spectroscopy assistance.
NR 51
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U1 39
U2 39
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1932-7447
J9 J PHYS CHEM C
JI J. Phys. Chem. C
PD DEC 1
PY 2016
VL 120
IS 47
BP 26710
EP 26719
DI 10.1021/acs.jpcc.6b10730
PG 10
WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science,
Multidisciplinary
SC Chemistry; Science & Technology - Other Topics; Materials Science
GA ED9AC
UT WOS:000389161300015
ER
PT J
AU Campbell, MS
Ryan, M
Wright, D
Devore, MD
Hoge, CW
AF Campbell, Marjorie S.
Ryan, Margaret
Wright, Daniel
Devore, Maria D.
Hoge, Charles W.
TI Postdeployment PTSD and Addictive Combat Attachment Behaviors in US
Military Service Members
SO AMERICAN JOURNAL OF PSYCHIATRY
LA English
DT Editorial Material
ID POSTTRAUMATIC-STRESS-DISORDER; SOLDIERS; TRAUMA
C1 [Campbell, Marjorie S.] Naval Hosp Camp Pendleton, Directorate Mental Hlth, Camp Pendleton, CA 92055 USA.
Naval Hosp Camp Pendleton, Clin Invest Program, Camp Pendleton, CA USA.
Walter Reed Army Inst Res, Ctr Psychiat & Neurosci, Silver Spring, MD USA.
RP Campbell, MS (reprint author), Naval Hosp Camp Pendleton, Directorate Mental Hlth, Camp Pendleton, CA 92055 USA.
EM marjorie.s.campbell.civ@mail.mil
NR 23
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U1 0
U2 0
PU AMER PSYCHIATRIC PUBLISHING, INC
PI ARLINGTON
PA 1000 WILSON BOULEVARD, STE 1825, ARLINGTON, VA 22209-3901 USA
SN 0002-953X
EI 1535-7228
J9 AM J PSYCHIAT
JI Am. J. Psychiat.
PD DEC
PY 2016
VL 173
IS 12
BP 1171
EP 1176
DI 10.1176/appi.ajp.2015.15101297
PG 6
WC Psychiatry
SC Psychiatry
GA ED7CB
UT WOS:000389012200005
PM 27903099
ER
PT J
AU Berkowitz, JF
Green, L
VanZomeren, CM
White, JR
AF Berkowitz, Jacob F.
Green, Lindsey
VanZomeren, Christine M.
White, John R.
TI Evaluating soil properties and potential nitrate removal in wetlands
created using an Engineering With Nature based dredged material
placement technique
SO ECOLOGICAL ENGINEERING
LA English
DT Article
DE Wetland creation; Soil properties; Dredged material; Nitrate removal;
Engineering With Nature; Atchafalaya River
ID GULF-OF-MEXICO; DENITRIFICATION RATES; MISSISSIPPI DELTA; MICROBIAL
BIOMASS; RIVER-BASIN; RESTORATION; MANAGEMENT; PHOSPHORUS; SEDIMENT;
SUPPORT
AB Many waterways around the globe, including those in southern Louisiana, require periodic dredging to maintain navigability in channels, rivers, and at ports. Traditionally, dredged materials are deposited in confined disposal facilities, relegated to deep open water disposal, or used as fill material to build wetlands. Over the past 15+ years, dredge material from the Atchafalaya River was strategically placed up-river of a small, natural shoal, located mid-channel, resulting in the creation of a wetland exhibiting many structural characteristics of the naturally occurring riverine wetlands within the basin. This construction practice adheres to Engineering With Nature (EWN) concepts which utilize natural processes to produce maximum benefit for navigation, while lowering economic costs and improving habitat features. The current study determined soil physical, nutrient, and biogeochemical properties at the EWN wetland and compares these characteristics to values observed at a traditional dredge shoreline material placement wetland (TDMP), essentially examining the effect of construction technique on soil biogeochemical properties. Soil total carbon and nitrogen at EWN continued to accumulate with time; however, TDMP exhibited a significantly higher degree of soil formation as indicated by lower bulk density, and higher soil organic matter, carbon, and nitrogen. Despite the observed differences, rates of potential nitrate removal and microbial biomass nitrogen did not differ between wetlands, suggesting that the nature based construction technique resulted in nutrient cycling and nitrate removal capacities equivalent to traditionally constructed dredged material wetlands in the region. Published by Elsevier B.V.
C1 [Berkowitz, Jacob F.; VanZomeren, Christine M.] US Army, Corps Engineers, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
[Green, Lindsey] Audubon Nat Inst, Aquat Ctr, New Orleans, LA 70118 USA.
[Green, Lindsey; White, John R.] Louisiana State Univ, Dept Oceanog & Coastal Sci, Wetland & Aquat Biogeochem Lab, Baton Rouge, LA 70803 USA.
RP Berkowitz, JF (reprint author), US Army, Corps Engineers, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
EM Jacob.F.Berkowitz@usace.army.mil
FU USACE Engineering with Nature program
FX Project funding was provided by the USACE Engineering with Nature
program manager Dr. Todd Bridges. Thanks to Dr. Burton Suedel and Kevin
Philley (USACE Engineer Research and Development Center) for providing
comments on the draft manuscript. Darrell Evans (USACE Engineer Research
and Development Center), Jeff Corbino and other staff at USACE New
Orleans District provided assistance with figures, logistics, and
background information. John Newton assisted with sinking an airboat
during field data collection.
NR 50
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U1 8
U2 8
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0925-8574
EI 1872-6992
J9 ECOL ENG
JI Ecol. Eng.
PD DEC
PY 2016
VL 97
BP 381
EP 388
DI 10.1016/j.ecoleng.2016.10.022
PG 8
WC Ecology; Engineering, Environmental; Environmental Sciences
SC Environmental Sciences & Ecology; Engineering
GA ED1CA
UT WOS:000388580200040
ER
PT J
AU Knap, J
Spear, C
Leiter, K
Becker, R
Powell, D
AF Knap, J.
Spear, C.
Leiter, K.
Becker, R.
Powell, D.
TI A computational framework for scale-bridging in multi-scale simulations
SO INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN ENGINEERING
LA English
DT Article
DE multi-scale modeling; scale-bridging; distributed multi-scale
simulation; finite element
AB A computational framework for scale-bridging in multi-scale simulations is presented. The framework enables seamless combination of at-scale models into highly dynamic hierarchies to build a multi-scale model. Its centerpiece is formulated as a standalone module capable of fully asynchronous operation. We assess its feasibility and performance for a two-scale model applied to two challenging test problems from impact physics. We find that the computational cost associated with using the framework may, as expected, become substantial. However, the framework has the ability of effortlessly combining at-scale models to render complex multi-scale models. The main source of the computational inefficiency of the framework is related to poor load balancing of the lower-scale model evaluation We demonstrate that the load balancing can be efficiently addressed by recourse to conventional load-balancing strategies. Copyright (c) 2016 John Wiley & Sons, Ltd.
C1 [Knap, J.; Leiter, K.] US Army Res Lab, Simulat Sci Branch, RDRL CIH C, Aberdeen, MD 21005 USA.
[Spear, C.] Johns Hopkins Univ, Maryland Adv Res Comp Ctr, Baltimore, MD 21218 USA.
[Becker, R.; Powell, D.] US Army Res Lab, Impact Phys Branch, RDRL WMP C, Aberdeen, MD 21005 USA.
RP Knap, J (reprint author), US Army Res Lab, Simulat Sci Branch, RDRL CIH C, Aberdeen, MD 21005 USA.
EM jaroslaw.knap.civ@mail.mil
NR 23
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Z9 0
U1 3
U2 3
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0029-5981
EI 1097-0207
J9 INT J NUMER METH ENG
JI Int. J. Numer. Methods Eng.
PD DEC
PY 2016
VL 108
IS 13
BP 1649
EP 1666
DI 10.1002/nme.5270
PG 18
WC Engineering, Multidisciplinary; Mathematics, Interdisciplinary
Applications
SC Engineering; Mathematics
GA ED1HE
UT WOS:000388595000004
ER
PT J
AU Nemeth, C
Blomberg, J
Argenta, C
Serio-Melvin, ML
Salinas, J
Pamplin, J
AF Nemeth, Christopher
Blomberg, Josh
Argenta, Christopher
Serio-Melvin, Maria L.
Salinas, Jose
Pamplin, Jeremy
TI Revealing ICU Cognitive Work Through Naturalistic Decision-Making
Methods
SO JOURNAL OF COGNITIVE ENGINEERING AND DECISION MAKING
LA English
DT Article
DE cognitive systems engineering; communication; decision support; domains;
health care; macrocognition
AB The fragile health of patients who are admitted to a burn intensive care unit (ICU) requires clinicians and clinical teams to perform complex cognitive work that includes time-pressured diagnostic and therapeutic decisions that are based on emergent and interrelated patient information. Barriers to clinician efforts delay patient care and increase care cost, length of stay, and the potential for misadventures. The Cooperative Communication System is a real-time information technology system in its final year of development that is designed to support individual and team cognitive work and communication in the burn ICU. The project has used cognitive systems engineering methods to reveal genotypes: the traits that mold this naturalistic decision-making work setting. Requirements derived from findings guided development of seven core features, configurable displays, and machine learning features that enable clinicians to obtain and use the most important information on individual patients and among and across patients. Recent evaluation data demonstrate the system's usability and value to the clinical staff. More efficient, reliable collaboration among members of the ICU staff who use the Cooperative Communication System is expected to improve patient safety and improve patient outcomes.
C1 [Nemeth, Christopher; Blomberg, Josh; Argenta, Christopher] Appl Res Associates Inc, 928 Wesley Ave, Evanston, IL 60202 USA.
[Serio-Melvin, Maria L.; Salinas, Jose; Pamplin, Jeremy] US Army Inst Surg Res, Brook Army Med Ctr, Joint Base San Antonio, San Antonio, TX USA.
RP Nemeth, C (reprint author), Appl Res Associates Inc, 928 Wesley Ave, Evanston, IL 60202 USA.
EM cnemeth@ara.com
FU U.S. Army Medical Research and Materiel Command [W81XWH-12-C-0126]
FX This work is supported by the U.S. Army Medical Research and Materiel
Command under Contract W81XWH-12-C-0126. The views, opinions, and/or
findings contained in this report are those of the authors and should
not be construed as an official Department of the Army position, policy,
or decision unless so designated by other documentation. In the conduct
of research where humans are the subjects, the investigators adhered to
the policies regarding the protection of human subjects as prescribed by
Code of Federal Regulations title 45, volume 1, part 46; title 32,
chapter 1, part 219; and title 21, chapter 1, part 50 (Protection of
Human Subjects).
NR 31
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U1 8
U2 8
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1555-3434
EI 2169-5032
J9 J COGN ENG DECIS MAK
JI J. Cogn. Eng. Decis. Mak.
PD DEC
PY 2016
VL 10
IS 4
BP 350
EP 368
DI 10.1177/1555343416664845
PG 19
WC Psychology, Experimental
SC Psychology
GA ED2RW
UT WOS:000388697200003
ER
PT J
AU Ward, CL
Pollot, BE
Goldman, SM
Greising, SM
Wenke, JC
Corona, BT
AF Ward, Catherine L.
Pollot, Beth E.
Goldman, Stephen M.
Greising, Sarah M.
Wenke, Joseph C.
Corona, Benjamin T.
TI Autologous Minced Muscle Grafts Improve Muscle Strength in a Porcine
Model of Volumetric Muscle Loss Injury
SO JOURNAL OF ORTHOPAEDIC TRAUMA
LA English
DT Article
DE regenerative medicine; orthopaedic trauma; skeletal muscle injury;
neuromuscular strength; regeneration; model development; muscle fibrosis
ID SKELETAL-MUSCLE; BIOLOGIC SCAFFOLD; IN-VITRO; TISSUE; REGENERATION; RAT;
REPAIR; TRANSPLANTATION; IMPLANTATION; CELLS
AB Objectives: The traumatic loss of muscle tissue, defined as volumetric muscle loss (VML) injury, has no definitive therapy. The purposes of this study were: (1) to develop a porcine model of VML and (2) to investigate autologous minced muscle grafts (1-mm(3) pieces of muscle) as a potential therapeutic. Minced grafts were evaluated because they have promoted fiber regeneration and functional recovery in rat VML models and do not require US Food and Drug Administration approval for clinical use.
Methods: In 5 female Yorkshire-cross pigs, approximate to 5 g (approximate to 20%) of tissue was excised from the peroneous tertius muscle (approximate to 3 x 3 x 1.5-cm defect) of each leg. The defect in one leg was treated with autologous minced grafts derived from the contralateral leg. Maximal isometric tetanic strength assessments of the dorsiflexor muscles (ie, the peroneous tertius muscle) were performed before and biweekly up to 12 weeks postinjury.
Results: VML injury resulted in a -43.5% +/- 7.2% strength deficit 12 weeks postinjury in nonrepaired legs. Autologous minced muscle graft repair significantly improved strength over 12 weeks (32% strength increase 12 weeks postinjury vs. nonrepaired muscles with a remaining -27.8% +/- 7.0% strength deficit; P < 0.001). Nonrepaired muscles developed extensive fibrosis and presented no evidence of muscle fiber regeneration within the defect area. Minced graft-treated muscles presented areas of putative de novo muscle fiber regeneration within the defect area, although extensive fibrotic tissue deposition was also present.
Conclusion: Autologous minced muscle grafts partially restored neuromuscular strength in a novel porcine model of VML.
C1 [Ward, Catherine L.; Pollot, Beth E.; Goldman, Stephen M.; Greising, Sarah M.; Wenke, Joseph C.; Corona, Benjamin T.] US Army, Extrem Trauma & Regenerat Med Task Area, Inst Surg Res, 3698 Chambers Pass,Bldg 3611, Ft Sam Houston, TX 78234 USA.
RP Corona, BT (reprint author), US Army, Extrem Trauma & Regenerat Med Task Area, Inst Surg Res, 3698 Chambers Pass,Bldg 3611, Ft Sam Houston, TX 78234 USA.
EM corona.benjamin.t@gmail.com
FU United States Army Clinical and Rehabilitative Medicine Research Program
FX Supported by the United States Army Clinical and Rehabilitative Medicine
Research Program.
NR 28
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U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0890-5339
EI 1531-2291
J9 J ORTHOP TRAUMA
JI J. Orthop. Trauma
PD DEC
PY 2016
VL 30
IS 12
BP E396
EP E403
DI 10.1097/BOT.0000000000000673
PG 8
WC Orthopedics; Sport Sciences
SC Orthopedics; Sport Sciences
GA ED6CG
UT WOS:000388941600004
PM 27466826
ER
PT J
AU Gonzalez, R
Jayakumar, P
Iagnemma, K
AF Gonzalez, Ramon
Jayakumar, Paramsothy
Iagnemma, Karl
TI An efficient method for increasing the accuracy of mobility maps for
ground vehicles
SO JOURNAL OF TERRAMECHANICS
LA English
DT Article
DE Mobility prediction; NATO Reference Mobility Model (NRMM); Variogram;
K-means; Man-made environment
ID GEOSTATISTICAL SAMPLING OPTIMIZATION
AB This paper presents an efficient method for increasing the accuracy of one key step regarding the process of determining a mobility map. That is, the interpolation of the original Digital Elevation Model (DEM) to a finer resolution before running multi-body-dynamics simulations. Specifically, this paper explores the use of fractal dimension and elevation range metrics for increasing the accuracy and reducing the computation time associated with the spatial interpolation ordinary kriging method. The first goal is to ensure the stationary variogram requirement. The second goal is to reduce kriging error or variance in the new predicted values. A novel segmentation-based approach has been proposed to divide the regions of interest into segments where stationarity is ensured. Empirical investigation based on real DEMs indicates the generality of the segmentation approach when natural and man-made terrains are considered. The proposed method leads to a more efficient computation burden and to more accurate results than the traditional approach. (C) 2016 ISTVS. Published by Elsevier Ltd. All rights reserved.
C1 [Gonzalez, Ramon; Iagnemma, Karl] MIT, 77 Massachusetts Ave,Bldg 35, Cambridge, MA 02139 USA.
[Jayakumar, Paramsothy] US Army, RDECOM TARDEC, 6501 E 11 Mile Rd,MS 157,Bldg 215, Warren, MI 48397 USA.
RP Gonzalez, R (reprint author), MIT, 77 Massachusetts Ave,Bldg 35, Cambridge, MA 02139 USA.
EM ramong@mit.edu; paramsothy.jayakumar.civ@mail.mil; kdi@mit.edu
FU TARDEC [W911NF-13-1-0063]
FX The research described in this publication was carried out at the
Massachusetts Institute of Technology, under the Army Research Project
Grant W911NF-13-1-0063 funded by TARDEC. UNCLASSIFIED: Distribution
Statement A. Approved for public release; distribution is unlimited.
#27272.
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U1 1
U2 1
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-4898
EI 1879-1204
J9 J TERRAMECHANICS
JI J. Terramech.
PD DEC
PY 2016
VL 68
BP 23
EP 35
DI 10.1016/j.jterra.2016.09.002
PG 13
WC Engineering, Environmental
SC Engineering
GA ED8CT
UT WOS:000389100300003
ER
PT J
AU Monninger, MK
Nguessan, CA
Blancett, CD
Kuehl, KA
Rossi, CA
Olschner, SP
Williams, PL
Goodman, SL
Sun, MG
AF Monninger, Mitchell K.
Nguessan, Chrystal A.
Blancett, Candace D.
Kuehl, Kathleen A.
Rossi, Cynthia A.
Olschner, Scott P.
Williams, Priscilla L.
Goodman, Steven L.
Sun, Mei G.
TI Preparation of viral samples within biocontainment for ultrastructural
analysis: Utilization of an innovative processing capsule for negative
staining
SO JOURNAL OF VIROLOGICAL METHODS
LA English
DT Article
DE TEM; Negative staining; mPrep; Biocontainment; Ebolavirus; Chikungunya
virus
ID ELECTRON-MICROSCOPY; VIRUSES
AB Transmission electron microscopy can be used to observe the ultrastructure of viruses and other microbial pathogens with nanometer resolution. In a transmission electron microscope (TEM), the image is created by passing an electron beam through a specimen with contrast generated by electron scattering from dense elements in the specimen. Viruses do not normally contain dense elements, so a negative stain that places dense heavy metal salts around the sample is added to create a dark border. To prepare a virus sample for a negative stain transmission electron microscopy, a virus suspension is applied to a TEM grid specimen support, which is a 3 mm diameter fragile specimen screen coated with a few nanometers of plastic film. Then, deionized (dI) water rinses and a negative stain solution are applied to the grid. All infectious viruses must be handled in a biosafety cabinet (BSC) and many require a biocontainment laboratory environment. Staining viruses in biosafety levels (BSL) 3 and 4 is especially challenging because the support grids are small, fragile, and easily moved by air currents. In this study we evaluated a new device for negative staining viruses called mPrep/g capsule. It is a capsule that holds up to two TEM grids during all processing steps and for storage after staining is complete. This study reports that the mPrep/g capsule method is valid and effective to negative stain virus specimens, especially in high containment laboratory environments. (C) 2016 The Authors. Published by Elsevier B.V.
C1 [Monninger, Mitchell K.; Nguessan, Chrystal A.; Blancett, Candace D.; Kuehl, Kathleen A.; Sun, Mei G.] US Army, Div Pathol, Med Res Inst Infect Dis, USAMRIID, 1425 Porter St, Ft Detrick, MD 21702 USA.
[Rossi, Cynthia A.; Olschner, Scott P.; Williams, Priscilla L.] US Army, Diagnost Syst Div, Med Res Inst Infect Dis, USAMRIID, 1425 Porter St, Ft Detrick, MD 21702 USA.
[Goodman, Steven L.] Microscopy Innovat LLC, Marshfield, WI USA.
RP Sun, MG (reprint author), US Army, Div Pathol, Med Res Inst Infect Dis, USAMRIID, 1425 Porter St, Ft Detrick, MD 21702 USA.
EM mei.g.sun.ctr@mail.mil
NR 17
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Z9 0
U1 3
U2 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0166-0934
EI 1879-0984
J9 J VIROL METHODS
JI J. Virol. Methods
PD DEC
PY 2016
VL 238
BP 70
EP 76
DI 10.1016/j.jviromet.2016.10.005
PG 7
WC Biochemical Research Methods; Biotechnology & Applied Microbiology;
Virology
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
Virology
GA ED8AJ
UT WOS:000389093800012
PM 27751950
ER
PT J
AU Reifman, J
Kumar, K
Wesensten, NJ
Tountas, NA
Balkin, TJ
Ramakrishnan, S
AF Reifman, Jaques
Kumar, Kamal
Wesensten, Nancy J.
Tountas, Nikolaos A.
Balkin, Thomas J.
Ramakrishnan, Sridhar
TI 2B-Alert Web: An Open-Access Tool for Predicting the Effects of
Sleep/Wake Schedules and Caffeine Consumption on Neurobehavioral
Performance
SO SLEEP
LA English
DT Article
DE biomathematical model; sleep schedule; caffeine model; prediction tool;
PVT
ID UNIFIED MODEL; DEPRIVATION; FATIGUE; IMPAIRMENT; VIGILANCE; ALCOHOL
AB Study Objectives: Computational tools that predict the effects of daily sleep/wake amounts on neurobehavioral performance are critical components of fatigue management systems, allowing for the identification of periods during which individuals are at increased risk for performance errors. However, none of the existing computational tools is publicly available, and the commercially available tools do not account for the beneficial effects of caffeine on performance, limiting their practical utility. Here, we introduce 2B-Alert Web, an open-access tool for predicting neurobehavioral performance, which accounts for the effects of sleep/wake schedules, time of day, and caffeine consumption, while incorporating the latest scientific findings in sleep restriction, sleep extension, and recovery sleep.
Methods: We combined our validated Unified Model of Performance and our validated caffeine model to form a single, integrated modeling framework instantiated as a Web-enabled tool. 2B-Alert Web allows users to input daily sleep/wake schedules and caffeine consumption (dosage and time) to obtain group-average predictions of neurobehavioral performance based on psychomotor vigilance tasks. 2B-Alert Web is accessible at: https://2b-alert-web.bhsai.org.
Results: The 2B-Alert Web tool allows users to obtain predictions for mean response time, mean reciprocal response time, and number of lapses. The graphing tool allows for simultaneous display of up to seven different sleep/wake and caffeine schedules. The schedules and corresponding predicted outputs can be saved as a Microsoft Excel file; the corresponding plots can be saved as an image file. The schedules and predictions are erased when the user logs off, thereby maintaining privacy and confidentiality.
Conclusions: The publicly accessible 2B-Alert Web tool is available for operators, schedulers, and neurobehavioral scientists as well as the general public to determine the impact of any given sleep/wake schedule, caffeine consumption, and time of day on performance of a group of individuals. This evidence-based tool can be used as a decision aid to design effective work schedules, guide the design of future sleep restriction and caffeine studies, and increase public awareness of the effects of sleep amounts, time of day, and caffeine on alertness.
C1 [Reifman, Jaques; Kumar, Kamal; Tountas, Nikolaos A.; Ramakrishnan, Sridhar] US Army, Dept Def Biotechnol, High Performance Comp Software Applicat Inst, Telemed & Adv Technol Res Ctr,Med Res & Mat Comma, Ft Detrick, MD USA.
[Wesensten, Nancy J.] FAA, Air Traff Org, Washington, DC USA.
[Balkin, Thomas J.] Walter Reed Army Inst Res, Behav Biol Branch, Silver Spring, MD USA.
RP Reifman, J (reprint author), US Army, Dept Def Biotechnol, High Performance Comp Software Applicat Inst,ATTN, Telemed & Adv Technol Res Ctr,Med Res & Mat Comma, 504 Scott St, Ft Detrick, MD 21702 USA.
EM jaques.reifman.civ@mail.mil
FU Military Operational Medicine Research Area Directorate of the U.S. Army
Medical Research and Materiel Command, Ft. Detrick, MD
FX This was not an industry supported study. This work was sponsored by the
Military Operational Medicine Research Area Directorate of the U.S. Army
Medical Research and Materiel Command, Ft. Detrick, MD. The authors have
indicated no financial conflicts of interest. The opinions and
assertions contained herein are the private views of the authors and are
not to be construed as official or as reflecting the views of the U.S.
Army or of the U.S. Department of Defense. The 2B-Alert Web tool is for
educational and informational purposes only. It should not be used for
or relied upon for predicting the performance of any specific individual
or the likelihood of errors or accidents by any specific individual or a
group of individuals. This paper has been approved for public release
with unlimited distribution.
NR 10
TC 0
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U1 6
U2 6
PU AMER ACAD SLEEP MEDICINE
PI WESTCHESTER
PA ONE WESTBROOK CORPORATE CTR, STE 920, WESTCHESTER, IL 60154 USA
SN 0161-8105
EI 1550-9109
J9 SLEEP
JI Sleep
PD DEC 1
PY 2016
VL 39
IS 12
BP 2157
EP 2159
AR PII sp-00246-16
DI 10.5665/sleep.6318
PG 3
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA ED5ZK
UT WOS:000388932700010
PM 27634801
ER
PT J
AU Rockwood, GA
Thompson, DE
Petrikovics, I
AF Rockwood, Gary A.
Thompson, David E.
Petrikovics, Ilona
TI Dimethyl trisulfide: A novel cyanide countermeasure
SO TOXICOLOGY AND INDUSTRIAL HEALTH
LA English
DT Article
DE Dimethyl trisulfide (DMTS, CAS#: 3658-80-8); cyanide antagonism; in
vitro sulfur donor reactivity; therapeutic antidotal efficacy
ID ANTAGONISM; SULFUR; IDENTIFICATION; INTOXICATION; ANTIDOTES; NITRITE;
AROMA
AB In the present studies, the in vitro and in vivo efficacies of a novel cyanide countermeasure, dimethyl trisulfide (DMTS), were evaluated. DMTS is a sulfur-based molecule found in garlic, onion, broccoli, and similar plants. DMTS was studied for effectiveness as a sulfur donor-type cyanide countermeasure. The sulfur donor reactivity of DMTS was determined by measuring the rate of the formation of the cyanide metabolite thiocyanate. In experiments carried out in vitro in the presence of the sulfurtransferase rhodanese (Rh) and at the experimental pH of 7.4, DMTS was observed to convert cyanide to thiocyanate with greater than 40 times higher efficacy than does thiosulfate, the sulfur donor component of the US Food and Drug Administration approved cyanide countermeasure Nithiodote (R). In the absence of Rh, DMTS was observed to be almost 80 times more efficient than sodium thiosulfate in vitro. The fact that DMTS converts cyanide to thiocyanate more efficiently than does thiosulfate both with and without Rh makes it a promising sulfur donor-type cyanide antidote (scavenger) with reduced enzyme dependence in vitro. The therapeutic cyanide antidotal efficacies for DMTS versus sodium thiosulfate were measured following intramuscular administration in a mouse model and expressed as antidotal potency ratios (APR = LD50 of cyanide with antidote/LD50 of cyanide without antidote). A dose of 100 mg/kg sodium thiosulfate given intramuscularly showed only slight therapeutic protection (APR = 1.1), whereas the antidotal protection from DMTS given intramuscularly at the same dose was substantial (APR = 3.3). Based on these data, DMTS will be studied further as a promising next-generation countermeasure for cyanide intoxication.
C1 [Rockwood, Gary A.] US Army Med Res Inst Chem Def, Analyt Toxicol Div, Aberdeen Proving Ground, MD 21010 USA.
[Thompson, David E.; Petrikovics, Ilona] Sam Houston State Univ, Dept Chem, Huntsville, TX 77340 USA.
RP Rockwood, GA (reprint author), US Army Med Res Inst Chem Def, Analyt Toxicol Div, Aberdeen Proving Ground, MD 21010 USA.
EM gary.a.rockwood.civ@mail.mil
FU Counter ACT Program, National Institutes of Health Office of the
Director; National Institute of Allergy and Infectious Diseases,
NIH/Department of Defense [AOD12060-001-00000/A120-B.P2012-01]; Robert A
Welch Foundation at Sam Houston State University, Huntsville, TX
[X-0011]
FX The author(s) disclosed receipt of the following financial support for
the research, authorship, and/or publication of this article: This
research was supported by the Counter ACT Program, National Institutes
of Health Office of the Director, and the National Institute of Allergy
and Infectious Diseases, NIH/Department of Defense Interagency Agreement
AOD12060-001-00000/A120-B.P2012-01), and the Robert A Welch Foundation
(X-0011) at Sam Houston State University, Huntsville, TX.
NR 40
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U1 4
U2 4
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0748-2337
EI 1477-0393
J9 TOXICOL IND HEALTH
JI Toxicol. Ind. Health
PD DEC
PY 2016
VL 32
IS 12
BP 2009
EP 2016
DI 10.1177/0748233715622713
PG 8
WC Public, Environmental & Occupational Health; Toxicology
SC Public, Environmental & Occupational Health; Toxicology
GA ED8HV
UT WOS:000389113500011
PM 26939832
ER
PT J
AU Mahdizadehaghdam, S
Wang, H
Krim, H
Dai, LY
AF Mahdizadehaghdam, Shahin
Wang, Han
Krim, Hamid
Dai, Liyi
TI Information Diffusion of Topic Propagation in Social Media
SO IEEE TRANSACTIONS ON SIGNAL AND INFORMATION PROCESSING OVER NETWORKS
LA English
DT Article
DE Computer networks; information diffusion; multi-layer network; topic
propagation
ID NETWORKS; MODEL
AB Real-world social and/or operational networks consist of agents with associated states, whose connectivity forms complex topologies. This complexity is further compounded by interconnected information layers, consisting, for instance, documents/resources of the agents which mutually share topical similarities. Our goal in this paper is to predict the specific states of the agents, as their observed resources evolve in time and get updated. The information diffusion among the agents and the publications themselves effectively result in a dynamic process which we capture by an interconnected system of networks (i.e., layered). More specifically, we use a notion of a supra-Laplacian matrix to address such a generalized diffusion of an interconnected network starting with the classical "graph Laplacian." The auxiliary and external input update is modeled by a multidimensional Brownian process, yielding two contributions to the variations in the states of the agents: one that is due to the intrinsic interactions in the network system, and the other due to the external inputs or innovations. A variation on this theme, a priori knowledge of a fraction of the agents' states is shown to lead to a Kalman predictor problem. This helps us refine the predicted states exploiting the estimation error in the agents' states. Three real-world datasets are used to evaluate and validate the information diffusion process in this novel-layered network approach. Our results demonstrate a lower prediction error when using the interconnected network rather than the single connectivity layer between the agents. The prediction error is further improved by using the estimated diffusion connection and by applying the Kalman approach with partial observations.
C1 [Mahdizadehaghdam, Shahin; Wang, Han; Krim, Hamid] North Carolina State Univ, Dept Elect & Comp Engn, Raleigh, NC 27606 USA.
[Dai, Liyi] Army Res Off, RTP, Raleigh, NC 27703 USA.
RP Mahdizadehaghdam, S (reprint author), North Carolina State Univ, Dept Elect & Comp Engn, Raleigh, NC 27606 USA.
EM smahdiz@ncsu.edu; hwang42@ncsu.edu; ahk@ncsu.edu; liyi.dai.civ@mail.mil
NR 42
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U1 8
U2 8
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 2373-776X
J9 IEEE TRANS SIGNAL IN
JI IEEE Trans. Signal Inf. Proc. Netw.
PD DEC
PY 2016
VL 2
IS 4
BP 569
EP 581
DI 10.1109/TSIPN.2016.2618324
PG 13
WC Engineering, Electrical & Electronic
SC Engineering
GA EC5UB
UT WOS:000388201000011
ER
PT J
AU Harrison, SA
Marri, SR
Chalasani, N
Kohli, R
Aronstein, W
Thompson, GA
Irish, W
Miles, MV
Xanthakos, SA
Lawitz, E
Noureddin, M
Schiano, TD
Siddiqui, M
Sanyal, A
Neuschwander-Tetri, BA
Traber, PG
AF Harrison, S. A.
Marri, S. R.
Chalasani, N.
Kohli, R.
Aronstein, W.
Thompson, G. A.
Irish, W.
Miles, M. V.
Xanthakos, S. A.
Lawitz, E.
Noureddin, M.
Schiano, T. D.
Siddiqui, M.
Sanyal, A.
Neuschwander-Tetri, B. A.
Traber, P. G.
TI Randomised clinical study: GR-MD-02, a galectin-3 inhibitor, vs. placebo
in patients having non-alcoholic steatohepatitis with advanced fibrosis
SO ALIMENTARY PHARMACOLOGY & THERAPEUTICS
LA English
DT Article
ID FATTY LIVER-DISEASE; HEPATIC-FIBROSIS; SERUM GALECTIN-3;
DIAGNOSTIC-VALUE; ALPHA-2-MACROGLOBULIN; BIOMARKERS; FIBROTEST; OBESITY;
MODEL
AB BackgroundNon-alcoholic steatohepatitis (NASH) and resultant liver fibrosis is a major health problem without approved pharmacotherapy. Pre-clinical results of GR-MD-02, a galectin-3 inhibitor, suggested potential efficacy in NASH with advanced fibrosis/cirrhosis and prompted initiation of a clinical development programme in NASH with advanced fibrosis.
AimTo evaluate the safety, pharmacokinetics and exploratory pharmacodynamic markers of GR-MD-02 in subjects having NASH with bridging fibrosis.
MethodsThe GT-020 study was a first-in-human, sequential dose-ranging, placebo controlled, double-blinded study with the primary objective to assess the safety, tolerability and dose limiting toxicity of GR-MD-02, in subjects with biopsy-proven NASH with advanced fibrosis (Brunt stage 3). The secondary objectives were to characterise first-dose and multiple-dose pharmacokinetic profiles and to evaluate changes in potential serum biomarkers and liver stiffness as assessed by FibroScan.
ResultsGR-MD-02 single and three weekly repeated of 2, 4 and 8mg/kg revealed no meaningful clinical differences in treatment emergent adverse events, vital signs, electrocardiographic findings or laboratory tests. Pharmokinetic parameters showed a dose-dependent relationship with evidence of drug accumulation following 8mg/kg (similar to twofold).
ConclusionsGR-MD-02 doses were in the upper range of the targeted therapeutic dose determined from pre-clinical data and were safe and well tolerated with evidence of a pharmacodynamic effect. These results provide support for a Phase 2 development programme in advanced fibrosis due to NASH.
C1 [Harrison, S. A.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA.
[Marri, S. R.; Chalasani, N.] Indiana Univ Sch Med, Indianapolis, IN 46202 USA.
[Kohli, R.; Miles, M. V.; Xanthakos, S. A.] Cincinnati Childrens Hosp Med Ctr, Cincinnati, OH 45229 USA.
[Aronstein, W.; Irish, W.] Clin Trial & Consulting, CTI, Cincinnati, OH USA.
GA Thompson Consulting, W Chester, OH USA.
[Lawitz, E.] Univ Texas Hlth Sci Ctr San Antonio, Texas Liver Inst, San Antonio, TX 78229 USA.
[Noureddin, M.] Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA.
[Schiano, T. D.] Icahn Sch Med Mt Sinai, New York, NY 10029 USA.
[Siddiqui, M.; Sanyal, A.] Virginia Commonwealth Univ, Sch Med, Richmond, VA USA.
[Neuschwander-Tetri, B. A.] St Louis Sch Med, St Louis, MO USA.
[Traber, P. G.] Galectin Therapeut Inc, Norcross, GA USA.
[Traber, P. G.] Emory Univ, Sch Med, Atlanta, GA USA.
RP Traber, PG (reprint author), Emory Univ, Sch Med, Galectin Therapeut, 4960 Peachtree Ind Blvd,Suite 240, Norcross, GA 30071 USA.
EM traber@galectintherapeutics.com
OI kohli, Rohit/0000-0002-0198-7703
FU Galectin Therapeutics Inc.; Galectin Therapeutics
FX This study, including the writing and preparation of this paper, was
funded in full by Galectin Therapeutics Inc. Initial data analyses were
undertaken by employees of CTI, Clinical Trial Consulting (Cincinnati,
OH) which was the contracted clinical research organisation responsible
for the operations of the clinical trial and received funding from
Galectin Therapeutics.
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U1 1
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PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0269-2813
EI 1365-2036
J9 ALIMENT PHARM THER
JI Aliment. Pharmacol. Ther.
PD DEC
PY 2016
VL 44
IS 11-12
BP 1183
EP 1198
DI 10.1111/apt.13816
PG 16
WC Gastroenterology & Hepatology; Pharmacology & Pharmacy
SC Gastroenterology & Hepatology; Pharmacology & Pharmacy
GA EB7UT
UT WOS:000387597000004
PM 27778367
ER
PT J
AU Austin, KG
Price, LL
McGraw, SM
McLellan, TM
Lieberman, HR
AF Austin, Krista G.
Price, Lori Lyn
McGraw, Susan M.
McLellan, Tom M.
Lieberman, Harris R.
TI Longitudinal trends in use of dietary supplements by US Army personnel
differ from those of civilians
SO APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
LA English
DT Article
DE protein; vitamin; mineral; Armed Forces; military; exercise
ID PHYSICAL-ACTIVITY; COLLEGE-STUDENTS; UNITED-STATES; SOLDIERS; PROTEIN;
ENERGY; HEALTH; PERFORMANCE; POPULATION; MILITARY
AB Prevalence and patterns of dietary supplement (DS) use by U.S. Army soldiers differ from the civilian population. Longitudinal trends in use of DSs by civilians have been examined, but are unavailable in subpopulations such as military service members. The present study examined longitudinal changes in DS use by soldiers. A standardized questionnaire on DS use was administered in 2006-2007 (N = 989) and 2010-2011 (N = 1196) to convenience samples of active duty soldiers. Data were weighted for total population demographics of age, sex, and rank. Regular use of DSs by soldiers increased significantly (56% +/- 1.6% vs. 64% +/- 1.7%; p <= 0.001) over the 4 years primarily because of an increase of DS use among the youngest 18-to 24-year-old soldiers (43.0% +/- 2.5% vs 62.3% +/- 2.4%; p <= 0.01). Protein (22% +/- 1.4% vs. 26% +/- 1.5%; p <= 0.001) and combination (10.0% +/- 1.0% vs. 24% +/- 1.4%; p <= 0.001) product consumption also increased over the 4 years. Individual vitamin and mineral use - including iron, magnesium, selenium, and vitamins A, B-6, B-12, and D - significantly increased as well (p <= 0.05). In addition, expenditures on DSs by soldiers increased over time (p < 0.01). Reasons reported by soldiers for DS use suggest use increased to meet the occupational demands of military service. Educational interventions to minimize inappropriate use of DSs by soldiers are necessary to reduce adverse events resulting from unnecessary use of DSs and the financial burden associated with their use.
C1 [Austin, Krista G.; McGraw, Susan M.; Lieberman, Harris R.] US Army Res Inst Environm Med, Mil Nutr Div, 10 Gen Greene Ave, Natick, MA 01760 USA.
[Austin, Krista G.] Henry Jackson Fdn, 6720A Rockledge Dr 100, Bethesda, MD 20817 USA.
[Price, Lori Lyn] Tufts Univ, Tufts Med Ctr, 800 Washington St, Boston, MA 02111 USA.
[McLellan, Tom M.] TM McLellan Res Inc, 25 Dorman Dr, Stouffville, ON L4A 8A7, Canada.
RP Lieberman, HR (reprint author), US Army Res Inst Environm Med, Mil Nutr Div, 10 Gen Greene Ave, Natick, MA 01760 USA.
EM harris.r.lieberman.civ@mail.mil
FU U.S. Army Medical Research and Materiel Command (USAMRMC); Department of
Defense Center Alliance for Nutrition and Dietary Supplements Research;
Oak Ridge Institute for Science and Education; Henry M. Jackson
Foundation
FX The authors would like to thank the U.S. Army personnel who participated
in this study and the healthcare staff for assisting with data
collection. This work was supported by the U.S. Army Medical Research
and Materiel Command (USAMRMC) and the Department of Defense Center
Alliance for Nutrition and Dietary Supplements Research. The opinions
contained herein are the private views of the authors and are not to be
construed as official or as reflecting the views of the Army or the
Department of Defense. Citations of commercial organizations and trade
names in this report do not constitute an official Department of the
Army endorsement or approval of the products or services of these
organizations. Approved for public release; distribution is unlimited.
T.M. McLellan was supported by the Oak Ridge Institute for Science and
Education, as well as through a consulting agreement with the Henry M.
Jackson Foundation for the Advancement of Military Medicine Inc.
NR 28
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U1 10
U2 10
PU CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 1715-5312
EI 1715-5320
J9 APPL PHYSIOL NUTR ME
JI Appl. Physiol. Nutr. Metab.
PD DEC
PY 2016
VL 41
IS 12
BP 1217
EP 1224
DI 10.1139/apnm-2016-0296
PG 8
WC Nutrition & Dietetics; Physiology; Sport Sciences
SC Nutrition & Dietetics; Physiology; Sport Sciences
GA EC4IR
UT WOS:000388091900001
PM 27809560
ER
PT J
AU Druwe, IL
Burgoon, LD
AF Druwe, Ingrid L.
Burgoon, Lyle D.
TI Response to Cohen et al. (2016) regarding response to Druwe and Burgoon
SO ARCHIVES OF TOXICOLOGY
LA English
DT Letter
ID INORGANIC ARSENIC EXPOSURE; LUNG-TUMORS; ARCH TOXICOL; MICE
C1 [Druwe, Ingrid L.] US EPA, Oak Ridge Inst Sci & Educ, Res Participat Program, Natl Ctr Environm Assessment,Off Res & Dev, Res Triangle Pk, NC 27709 USA.
[Burgoon, Lyle D.] US Army Engineer Res & Dev Ctr, Res Triangle Pk, NC USA.
RP Druwe, IL (reprint author), US EPA, Oak Ridge Inst Sci & Educ, Res Participat Program, Natl Ctr Environm Assessment,Off Res & Dev, Res Triangle Pk, NC 27709 USA.
EM druwe.ingrid@epa.gov
OI Burgoon, Lyle/0000-0003-4977-5352
NR 10
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U1 2
U2 2
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0340-5761
EI 1432-0738
J9 ARCH TOXICOL
JI Arch. Toxicol.
PD DEC
PY 2016
VL 90
IS 12
BP 3131
EP 3132
DI 10.1007/s00204-016-1858-9
PG 2
WC Toxicology
SC Toxicology
GA EB9FH
UT WOS:000387697600019
PM 27717971
ER
PT J
AU Rivera, OG
Long, WR
Weiss, CA
Moser, RD
Williams, BA
Torres-Cancel, K
Gore, ER
Allison, PG
AF Rivera, O. G.
Long, W. R.
Weiss, C. A., Jr.
Moser, R. D.
Williams, B. A.
Torres-Cancel, K.
Gore, E. R.
Allison, P. G.
TI Effect of elevated temperature on alkali-activated geopolymeric binders
compared to portland cement-based binders
SO CEMENT AND CONCRETE RESEARCH
LA English
DT Article
DE Alkali-activated binders; Geopolymers; Elevated temperatures; Mechanical
properties; TGA; XRD; CT microtomography
ID FLY-ASH; THERMAL-BEHAVIOR; FIRE; CONCRETE; STRENGTH; EXPOSURE; MORTARS
AB This research focused on developing thermally-stable materials based on alkali-activation of slag, fly ash, and metakaolin compared to portland cement mixtures by using a hierarchical approach to material design. At lower length scales, X-ray diffraction (XRD) characterized the mineralogy that coupled to higher length scale experiments using thermogravimetric analysis (TGA) for determining the materials thermal stability. Additionally, high-energy X-ray computed microtomography (mu CT) determined the best-performing material formulation that minimized thermal damage when exposed to high temperatures (650 degrees C). The thermal loading was ramped up to 650 degrees C from ambient temperature in 60 s and then held for a total of 10 min. The mu CT identified that the alkali-activated fly ash mortar had less initial porosity than the ordinary portland cement mixtures, with more than 66% of the pores between 20 and 50 mu m in diameter. Consequently, the alkali-activated fly ash mortar was able to dissipate approximately 565 degrees C in just 50 mm of material, outperforming all the other mixes studied in this paper with mu CT confirming minimal damage after the temperature exposure. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Rivera, O. G.; Allison, P. G.] Univ Alabama, Dept Mech Engn, Tuscaloosa, AL 35487 USA.
[Long, W. R.; Weiss, C. A., Jr.; Moser, R. D.; Williams, B. A.; Torres-Cancel, K.; Gore, E. R.] US Army Corps Engineers, Engineer Res & Dev Ctr, Vicksburg, MS USA.
RP Allison, PG (reprint author), Univ Alabama, Dept Mech Engn, Tuscaloosa, AL 35487 USA.
EM pallison@eng.ua.edu
FU U.S. Army Engineer Research and Development Center Military Engineering
6.1 Basic Research Program
FX Funding for this work was provided by the U.S. Army Engineer Research
and Development Center Military Engineering 6.1 Basic Research Program.
Permission to publish was granted by Director, Geotechnical and
Structures Laboratory, U.S. Army Engineer Research and Development
Center.
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PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0008-8846
EI 1873-3948
J9 CEMENT CONCRETE RES
JI Cem. Concr. Res.
PD DEC
PY 2016
VL 90
BP 43
EP 51
DI 10.1016/j.cemconres.2016.09.013
PG 9
WC Construction & Building Technology; Materials Science, Multidisciplinary
SC Construction & Building Technology; Materials Science
GA EC3VV
UT WOS:000388056100006
ER
PT J
AU Smith, M
Piehler, T
Benjamin, R
Farizatto, KL
Pait, MC
Almeida, MF
Ghukasyan, VV
Bahr, BA
AF Smith, Marquitta
Piehler, Thuvan
Benjamin, Richard
Farizatto, Karen L.
Pait, Morgan C.
Almeida, Michael F.
Ghukasyan, Vladimir V.
Bahr, Ben A.
TI Blast waves from detonated military explosive reduce GluR1 and
synaptophysin levels in hippocampal slice cultures
SO EXPERIMENTAL NEUROLOGY
LA English
DT Article
DE Blast-induced injury; Military explosive; GluR1; RDX; Shockwave;
Synaptic decline; Synaptophysin; TBI; Traumatic brain injury
ID TRAUMATIC BRAIN-INJURY; LONG-TERM POTENTIATION; ACID AMIDE HYDROLASE;
SYNAPTIC PLASTICITY; IN-VITRO; GLUTAMATE RECEPTORS; RAT HIPPOCAMPUS;
COGNITIVE IMPAIRMENT; PROTEIN ACCUMULATION; ALZHEIMER-DISEASE
AB Explosives create shockwaves that cause blast-induced neurotrauma, one of the most common types of traumatic brain injury (TBI) linked to military service. Blast-induced TBIs are often associated with reduced cognitive and behavioral functions due to a variety of factors. To study the direct effects of military explosive blasts on brain tissue, we removed systemic factors by utilizing rat hippocampal slice cultures. The long-term slice cultures were briefly sealed air-tight in serum-free medium, lowered into a 37 degrees C water-filled tank, and small 1.7-gram assemblies of cyclotrimethylene trinitramine (RDX) were detonated 15 cm outside the tank, creating a distinct shock wave recorded at the culture plate position. Compared to control mock-treated groups of slices that received equal submerge time, 1-3 blast impacts caused a dose-dependent reduction in the AMPA receptor subunit GluR1. While only a small reduction was found in hippocampal slices exposed to a single RDX blast and harvested 1-2 days later, slices that received two consecutive RDX blasts 4 min apart exhibited a 26-40% reduction in GluR1, and the receptor subunit was further reduced by 64-72% after three consecutive blasts. Such loss correlated with increased levels of HDAC2, a histone deacetylase implicated in stress-induced reduction of glutamatergic transmission. No evidence of synaptic marker recovery was found at 72 h post-blast. The presynaptic marker synaptophysin was found to have similar susceptibility as GluR1 to the multiple explosive detonations. In contrast to the synaptic protein reductions, actin levels were unchanged, spectrin breakdown was not detected, and Fluoro-Jade B staining found no indication of degenerating neurons in slices exposed to three RDX blasts, suggesting that small, sub-lethal explosives are capable of producing selective alterations to synaptic integrity. Together, these results indicate that blast waves from military explosive cause signs of synaptic compromise without producing severe neurodegeneration, perhaps explaining the cognitive and behavioral changes in those blast-induced TBI sufferers that have no detectable neuropathology. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Smith, Marquitta; Farizatto, Karen L.; Pait, Morgan C.; Almeida, Michael F.; Bahr, Ben A.] Univ North Carolina Pembroke, Biotechnol Res & Training Ctr, Pembroke, NC 28372 USA.
[Piehler, Thuvan; Benjamin, Richard] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA.
[Ghukasyan, Vladimir V.] Univ North Carolina Chapel Hill, Neurosci Ctr, Dept Cell Biol & Physiol, Chapel Hill, NC 27599 USA.
RP Bahr, BA (reprint author), Univ North Carolina Pembroke, Biotechnol Res & Training Ctr, Pembroke, NC 28372 USA.
EM Bahr@uncp.edu
FU U.S. Army Research Laboratory; U.S. Army Research Office
[W911NF-14-2-0087]; Department of Defense Research and Education Program
[W911NF-15-1-0432]; NIH RISE grant [5R25GM077634-04]
FX This material is based upon work supported primarily by the U.S. Army
Research Laboratory and the U.S. Army Research Office under grant number
W911NF-14-2-0087 (BAB). University of North Carolina-Pembroke
researchers were also supported in part by grant W911NF-15-1-0432 from
the Department of Defense Research and Education Program (BAB) and NIH
RISE grant 5R25GM077634-04 to University of North Carolina-Pembroke. The
funding agencies had no role in study design, data collection and
analysis, or decision to publish. We thank Heather Romine, Manager of
the William C. Friday Laboratory, for excellent technical assistance,
and Greg Georgevitch (retired U.S. Army career NCO) and Nicole Zander
and Rohan Banton (U.S. Army Research Laboratory, Aberdeen Proving
Ground, Maryland) for helpful discussions.
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PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0014-4886
EI 1090-2430
J9 EXP NEUROL
JI Exp. Neurol.
PD DEC
PY 2016
VL 286
BP 107
EP 115
DI 10.1016/j.expneurol.2016.10.002
PG 9
WC Neurosciences
SC Neurosciences & Neurology
GA EC3ZB
UT WOS:000388064500011
PM 27720798
ER
PT J
AU Muraskin, J
Dodhia, S
Lieberman, G
Garcia, JO
Verstynen, T
Vettel, JM
Sherwin, J
Sajda, P
AF Muraskin, Jordan
Dodhia, Sonam
Lieberman, Gregory
Garcia, Javier O.
Verstynen, Timothy
Vettel, Jean M.
Sherwin, Jason
Sajda, Paul
TI Brain dynamics of post-task resting state are influenced by expertise:
Insights from baseball players
SO HUMAN BRAIN MAPPING
LA English
DT Article
DE EEG; fMRI; simultaneous; DTI; expertise; baseball; resting-state
ID PERCEPTUAL DECISION-MAKING; INDEPENDENT COMPONENT ANALYSIS; EEG ALPHA
OSCILLATIONS; EVENT-RELATED FMRI; FUNCTIONAL CONNECTIVITY;
BETA-SYNCHRONIZATION; SUBTHALAMIC NUCLEUS; RESPONSE-INHIBITION; INSULA
ACTIVATION; SPATIAL ATTENTION
AB Post-task resting state dynamics can be viewed as a task-driven state where behavioral performance is improved through endogenous, non-explicit learning. Tasks that have intrinsic value for individuals are hypothesized to produce post-task resting state dynamics that promote learning. We measured simultaneous fMRI/EEG and DTI in Division-1 collegiate baseball players and compared to a group of controls, examining differences in both functional and structural connectivity. Participants performed a surrogate baseball pitch Go/No-Go task before a resting state scan, and we compared post-task resting state connectivity using a seed-based analysis from the supplementary motor area (SMA), an area whose activity discriminated players and controls in our previous results using this task. Although both groups were equally trained on the task, the experts showed differential activity in their post-task resting state consistent with motor learning. Specifically, we found (1) differences in bilateral SMA-L Insula functional connectivity between experts and controls that may reflect group differences in motor learning, (2) differences in BOLD-alpha oscillation correlations between groups suggests variability in modulatory attention in the post-task state, and (3) group differences between BOLD-beta oscillations that may indicate cognitive processing of motor inhibition. Structural connectivity analysis identified group differences in portions of the functionally derived network, suggesting that functional differences may also partially arise from variability in the underlying white matter pathways. Generally, we find that brain dynamics in the post-task resting state differ as a function of subject expertise and potentially result from differences in both functional and structural connectivity. Hum Brain Mapp 37:4454-4471, 2016. (c) 2016 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc.
C1 [Muraskin, Jordan; Dodhia, Sonam; Sherwin, Jason; Sajda, Paul] Columbia Univ, Dept Biomed Engn, New York, NY 10027 USA.
[Lieberman, Gregory; Garcia, Javier O.; Vettel, Jean M.] US Army Res Lab, Human Res & Engn Directorate, Aberdeen, MD USA.
[Lieberman, Gregory; Vettel, Jean M.] Univ Penn, Dept Bioengn, Philadelphia, PA 19104 USA.
[Verstynen, Timothy] Carnegie Mellon Univ, Dept Psychol, Pittsburgh, PA 15213 USA.
[Verstynen, Timothy] Carnegie Mellon Univ, Ctr Neural Basis Cognit, Pittsburgh, PA 15213 USA.
[Vettel, Jean M.] Univ Calif Santa Barbara, Dept Psychol & Brain Sci, Santa Barbara, CA 93106 USA.
RP Muraskin, J; Sajda, P (reprint author), Columbia Univ, Dept Biomed Engn, New York, NY 10027 USA.
EM jsm2112@columbia.edu; psajda@columbia.edu
OI Verstynen, Timothy /0000-0003-4720-0336
FU National Institutes of Health [R01-MH085092, T35-AG044303]; U.S. Army
Research Laboratory [W911NF-10-2-0022]
FX Contract grant sponsor: National Institutes of Health; Contract grant
numbers: R01-MH085092, T35-AG044303; Contract grant sponsor: U.S. Army
Research Laboratory under Cooperative Agreement Number W911NF-10-2-0022.
NR 93
TC 0
Z9 0
U1 12
U2 12
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1065-9471
EI 1097-0193
J9 HUM BRAIN MAPP
JI Hum. Brain Mapp.
PD DEC
PY 2016
VL 37
IS 12
BP 4454
EP 4471
DI 10.1002/hbm.23321
PG 18
WC Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical
Imaging
SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging
GA EB5FL
UT WOS:000387399200017
PM 27448098
ER
PT J
AU Cook, JB
Riccio, AI
Anderson, T
Chen, WC
Shaha, SH
Wimberly, RL
AF Cook, Jay B.
Riccio, Anthony I.
Anderson, Terrence
Chen, Weichen
Shaha, Steven H.
Wimberly, Robert L.
TI Outcomes After Surgical Treatment of Adolescent Intra-articular Distal
Humerus Fractures
SO JOURNAL OF PEDIATRIC ORTHOPAEDICS
LA English
DT Article
DE adolescent; intra-articular distal humerus fracture; complications;
neurologic injury
ID T-CONDYLAR FRACTURES; PARATRICIPITAL POSTERIOR APPROACH; TRICEPS-SPARING
APPROACH; OPEN REDUCTION; INTERCONDYLAR FRACTURES; SUPRACONDYLAR
FRACTURE; INTERNAL-FIXATION; CYBEX EVALUATION; CHILDREN; MOTION
AB Background: To determine the radiographic and clinical outcomes of the surgical management of adolescent intra-articular distal humerus fractures.
Methods: We performed a retrospective review of the clinical and radiographic outcomes of 31 consecutive adolescent patients surgically treated for acute distal humerus intra-articular fractures. Nine patients returned for objective measures of range of motion, strength testing, and completion of validated outcome scores including the Mayo Elbow Performance Score (MEPS); The Disabilities of the Arm, Shoulder, and Hand Score (DASH); and the SF-36.
Results: The average age at the time of injury was 13.5 years (range, 12 to 16 y) with a mean follow-up of 1.22 years (range, 9 d to 5.5 y). Multiple surgical approaches were performed. Overall, the active range of motion for our patients was 10.7 to 133.9 degrees with a mean arc of 123.4 degrees. AO classification type C2 and C3 injuries lost significantly more motion than other fracture patterns. Twelve patients sustained perioperative nerve palsies that resolved by final follow-up; seven of these nerve injuries were iatrogenic and sustained during a Bryan-Morrey tricepital slide approach. Eight patients required implant removal; 7 of these patients had prominent olecranon screws after an olecranon osteotomy. Including postoperative neuropathies, there were 20 complications in 15 patients. Thirteen complications in 9 patients required a return to the operating room. Of the 9 patients who returned for objective testing, there was no statistically significant loss of range of motion or strength of the injured extremity when compared with the uninjured limb. The MEPS revealed 6 excellent, 1 good, and 2 fair results. The average DASH score was 5.1 (range, 0 to 19.1) and the physical (average 55.7; range, 47.4 to 59.0) and mental components (average 54.2; range, 29.8 to 63.4) of the SF-36 were comparable.
Conclusions: After surgical intervention for an adolescent intra-articular distal humerus fracture, one can expect no significant loss of motion or strength. The reported outcomes are not all excellent. The peri-operative complication rates are high and may be related to surgical approach and fracture pattern.
Level of Evidence: Level IV.
C1 [Cook, Jay B.; Chen, Weichen] Tripler Army Med Ctr, Honolulu, HI 96859 USA.
[Riccio, Anthony I.; Wimberly, Robert L.] Texas Scottish Rite Hosp Children, Dallas, TX 75219 USA.
[Riccio, Anthony I.; Wimberly, Robert L.] Childrens Med Ctr, Dallas, TX 75235 USA.
[Anderson, Terrence] Walter Reed Natl Mil Med Ctr, Washington, DC USA.
[Shaha, Steven H.] Principle Outcomes, Ctr Policy & Publ Adm, Draper, UT USA.
RP Wimberly, RL (reprint author), TSRH, 2222 Welborn St, Dallas, TX 75219 USA.
EM lane.wimberly@tsrh.org
NR 22
TC 0
Z9 0
U1 3
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0271-6798
EI 1539-2570
J9 J PEDIATR ORTHOPED
JI J. Pediatr. Orthop.
PD DEC
PY 2016
VL 36
IS 8
BP 773
EP 779
DI 10.1097/BPO.0000000000000555
PG 7
WC Orthopedics; Pediatrics
SC Orthopedics; Pediatrics
GA EC3EK
UT WOS:000388008100006
PM 26090965
ER
PT J
AU Kellogg, F
McWilliams, B
Cho, K
AF Kellogg, Frank
McWilliams, Brandon
Cho, Kyu
TI Effect of Current Pathways During Spark Plasma Sintering of an Aluminum
Alloy Powder
SO METALLURGICAL AND MATERIALS TRANSACTIONS A-PHYSICAL METALLURGY AND
MATERIALS SCIENCE
LA English
DT Article
ID SINTERING/SYNTHESIS PROCESS; FUNDAMENTAL INVESTIGATIONS;
MECHANICAL-PROPERTIES; ELECTRIC-FIELD; GRAIN-GROWTH; MICROSTRUCTURE;
DENSIFICATION; REACTIVITY; CERAMICS; PRESSURE
AB Spark plasma sintering has been a well-studied processing technique primarily for its very high cooling and heating rates. However, the underlying phenomenon driving the sintering behavior of powders under an electric field is still poorly understood. In this study, we look at the effect of changing current pathways through the powder bed by changing die materials, from conductive graphite to insulating boron nitride for sintering aluminum alloy 5083 powder. We found that the aluminum powder itself was insulating and that by changing the current paths, we had to find alternate processing methods to initiate sintering. Altering the current pathways led to faster temperature raises and faster melting (and potentially densification) of the aluminum powder. A flash sintering effect in metallic powders is observed in which the powder compact undergoes a rapid transition from electrically insulating to conducting at a temperature of 583 K (310 A degrees C).
C1 [Kellogg, Frank] Bowhead Sci & Technol, Belcamp, MD 21017 USA.
[McWilliams, Brandon; Cho, Kyu] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA.
RP Kellogg, F (reprint author), Bowhead Sci & Technol, Belcamp, MD 21017 USA.
EM franklin.r.kellogg.ctr@mail.mil
NR 35
TC 0
Z9 0
U1 8
U2 8
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1073-5623
EI 1543-1940
J9 METALL MATER TRANS A
JI Metall. Mater. Trans. A-Phys. Metall. Mater. Sci.
PD DEC
PY 2016
VL 47A
IS 12
BP 6353
EP 6367
DI 10.1007/s11661-016-3803-1
PG 15
WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical
Engineering
SC Materials Science; Metallurgy & Metallurgical Engineering
GA EC1HR
UT WOS:000387856000072
ER
PT J
AU Marusich, LR
Buchler, N
AF Marusich, Laura R.
Buchler, Norbou
TI Time series modeling of Army Mission Command communication networks: an
event-driven analysis
SO COMPUTATIONAL AND MATHEMATICAL ORGANIZATION THEORY
LA English
DT Article
DE Time series analysis; Communication network; Event-driven analysis;
Mission Command; Dynamic networks; Social network analysis
ID HEAVY TAILS; PERFORMANCE; DYNAMICS
AB We examine the communication time series of a fully-networked Army coalition command and control organization. The network comprised two echelons of command, at the Division and Brigade levels, over a 2-week military scenario exercise involving a Mission Command staff communicating over email and phone. We used time series analysis to predict the communications record based on an external work variable of the number of important scenario events occurring across time. After taking into account structural features of the time series-decreasing communications over time, a network crash, and the transition between weeks-we examined the remaining variability in email and phone communication. We found that the exercise scenario events were not a significant predictor of the Divisional communications, which were best fit by an auto-regressive model of order 1, meaning that the best predictor of the volume of communications at a given time point was the volume of communications on the immediately preceding time point. The occurrence of scenario events, however, did predict the Brigade communication time series, which were well fit by a lag dependent variable model. These results demonstrate that Brigade communications responded to and could be predicted by battlefield events, whereas the Division communications were only predicted by their own past values. These results highlight the importance of modeling environmental work events to predict organizational communication time series and suggest that network communications are perhaps increasingly dependent upon battlefield events for lower echelons of command closer to the tactical edge.
C1 [Marusich, Laura R.; Buchler, Norbou] US Army Res Lab, Aberdeen, MD 21005 USA.
RP Marusich, LR (reprint author), US Army Res Lab, Aberdeen, MD 21005 USA.
EM laura.r.marusich@mail.mil
NR 35
TC 0
Z9 0
U1 2
U2 2
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1381-298X
EI 1572-9346
J9 COMPUT MATH ORGAN TH
JI Comput. Math. Organ. Theory
PD DEC
PY 2016
VL 22
IS 4
BP 467
EP 486
DI 10.1007/s10588-016-9211-7
PG 20
WC Computer Science, Interdisciplinary Applications; Mathematics,
Interdisciplinary Applications; Social Sciences, Mathematical Methods
SC Computer Science; Mathematics; Mathematical Methods In Social Sciences
GA EB4PV
UT WOS:000387355600004
ER
PT J
AU Means, C
Camacho, M
Capasso, R
AF Means, Casey
Camacho, Macario
Capasso, Robson
TI Long-Term Outcomes of Radiofrequency Ablation of the Inferior Turbinates
SO INDIAN JOURNAL OF OTOLARYNGOLOGY AND HEAD & NECK SURGERY
LA English
DT Article
DE Turbinates; Turbinoplasty; Radiofrequency ablation; Nasal obstruction;
Continuous positive airway pressure
ID NASAL OBSTRUCTION; HYPERTROPHY; VALIDATION; REDUCTION; TRIAL
AB Radiofrequency ablation of the inferior turbinates (RFAIT) is a minimally invasive surgical technique that reduces turbinate size and decreases nasal obstruction. Few studies have assessed long-term outcomes of this procedure using standardized, symptom-specific evaluation instruments. The primary aim of this study is to assess the long-term effectiveness of RFAIT using a standardized, symptom-specific evaluation instrument. An additional outcome evaluated is the effect of RFAIT on therapeutic CPAP pressures in centimetres of water pressure (cwp) and overall CPAP use. Patients who had received RFAIT > 14 months previously were identified via retrospective chart review and underwent a telephone interview with several questions to include the Nasal Obstruction Symptom Evaluation (NOSE) scale. Additionally, data regarding therapeutic pressures for continuous positive pressure devices (CPAP) and CPAP use was obtained for patients using these devices as treatment for obstructive sleep apnoea. The average NOSE scale score for the 40 patients who completed the NOSE scale questionnaire in our study was 6.35 +/- 3.98 (0-20 scale). Crusting and mild, self-resolving epistaxis were the most common complications in the perioperative period. In general, unforeseen complications occurred in < 13 % of patients. The mean therapeutic CPAP pressures reduced from 11.4 +/- 2.7 to 10.1 +/- 3.2 cwp, p = 0.085. This study supports that radiofrequency ablation of the inferior turbinates has low complication rates, is well-tolerated, may decrease therapeutic CPAP pressures, and provides symptomatic improvement that is sustained > 14 months post-procedure.
C1 [Means, Casey] Oregon Hlth & Sci Univ, Dept Otolaryngol Head & Neck Surg, Portland, OR 97201 USA.
[Camacho, Macario] Tripler Army Med Ctr, Dept Surg, Div Otolaryngol Head & Neck Surg, Sleep Surg Sub Div, 1 Jarrett White Rd, Honolulu, HI 96859 USA.
[Capasso, Robson] Stanford Univ, Hosp & Clin, Dept Otolaryngol Head & Neck Surg, Sleep Surg Div, Stanford, CA 94305 USA.
RP Camacho, M (reprint author), Tripler Army Med Ctr, Dept Surg, Div Otolaryngol Head & Neck Surg, Sleep Surg Sub Div, 1 Jarrett White Rd, Honolulu, HI 96859 USA.
EM drcamachoent@yahoo.com
OI Camacho, Macario/0000-0001-9200-9085
NR 12
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER INDIA
PI NEW DELHI
PA 7TH FLOOR, VIJAYA BUILDING, 17, BARAKHAMBA ROAD, NEW DELHI, 110 001,
INDIA
SN 2231-3796
EI 0973-7707
J9 INDIAN J OTOLARYNGOL
JI Indian J. Otolaryngol. Head Neck Surg.
PD DEC
PY 2016
VL 68
IS 4
BP 424
EP 428
DI 10.1007/s12070-015-0912-x
PG 5
WC Surgery
SC Surgery
GA EB3BJ
UT WOS:000387236200007
PM 27833866
ER
PT J
AU Ghosh, S
Shahba, A
Tu, XH
Huskins, EL
Schuster, BE
AF Ghosh, Somnath
Shahba, Ahmad
Tu, Xiaohui
Huskins, Emily L.
Schuster, Brian E.
TI Crystal plasticity FE modeling of Ti alloys for a range of strain-rates.
Part II: Image-based model with experimental validation
SO INTERNATIONAL JOURNAL OF PLASTICITY
LA English
DT Article
DE Polycrystalline material; Image-based crystal plasticity;
Microstructures; Constitutive Behaviour; Finite elements
ID GENERATED SERIAL SECTIONS; TITANIUM SINGLE-CRYSTALS;
FINITE-ELEMENT-ANALYSIS; DEFORMATION; MICROSTRUCTURE; FRAMEWORK;
RECONSTRUCTION; NUCLEATION; KINETICS; STRESS
AB The second of this two-part paper develops an image-based crystal plasticity finite element model for simulating hcp metals deforming at a wide of range of strain-rates. It incorporates a unified flow rule based crystal plasticity constitutive model, combining the thermally-activated and drag-dominated stages of dislocation glide, proposed in part I (Shahba and Ghosh, 2016). The image-based CPFE uses 3D statistically-equivalent virtual microstructures that are constructed by stereology and statistics from 2D surface EBSD maps. The statistically equivalent virtual microstructures are constructed for the Ti-7Al alloy in as-rolled (AR) and rolled-annealed (RA) conditions. The virtual microstructures are discretized into, 3D tetrahedral elements that are stabilized to yield locking-free large deformation FE results. This paper demonstrates the competency of the model for simulating deformation of the polycrystalline Ti-7Al alloy microstructures under quasi-static and high rates of deformation. Room temperature compression tests at quasi-static (10(-3)s(-1)) and dynamic strain rates (1000-4000s(-1)) are performed and used to calibrate and validate the constitutive model. The simulations reveal that the decrease in the hardening rate is significant under adiabatic conditions due to the promotion of slip-driven plasticity. The effect of degradation of elastic constants with temperature on the macroscopic behavior is noticeable only at the later stages of deformation. A study on adiabatic heating reveals that grains undergoing severe plastic deformation do not necessarily yield higher temperatures. In contrast, grains that are less favorably oriented for dislocation slip could experience higher adiabatic heating due to higher local stresses. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Ghosh, Somnath] Johns Hopkins Univ, Dept Civil, Baltimore, MD 21218 USA.
[Ghosh, Somnath] Johns Hopkins Univ, Dept Mech Engn, Baltimore, MD 21218 USA.
[Shahba, Ahmad; Tu, Xiaohui] Johns Hopkins Univ, Dept Civil Engn, Baltimore, MD 21218 USA.
[Huskins, Emily L.] US Naval Acad, Dept Mech Engn, Annapolis, MD 21402 USA.
[Schuster, Brian E.] US Army, Res Lab, RDRL WM, Aberdeen Proving Ground, MD USA.
RP Ghosh, S (reprint author), 3400 N Charles St, Baltimore, MD 21218 USA.
EM sghosh20@jhu.edu
FU Army Research Office [W911NF-12-1-0376]; Office of Naval research
[N00014-15-1-2040]
FX This work has been supported by the Army Research Office through grant
No. W911NF-12-1-0376 (Program Manager: Dr. A. Rubinstein) and by the
Office of Naval research through grant No. N00014-15-1-2040 (Program
Manager: Mr. W. Nickerson). The authors would like to thank Dr. Adam
Pilchak of AFRL-WPAFB for providing the Ti-7Al samples. Computing
support by the Homewood High Performance Compute Cluster (HHPC) and the
Maryland Advanced Research Computing Center (MARCC) is gratefully
acknowledged.
NR 45
TC 1
Z9 1
U1 9
U2 9
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0749-6419
EI 1879-2154
J9 INT J PLASTICITY
JI Int. J. Plast.
PD DEC
PY 2016
VL 87
BP 69
EP 85
DI 10.1016/j.ijplas.2016.09.003
PG 17
WC Engineering, Mechanical; Materials Science, Multidisciplinary; Mechanics
SC Engineering; Materials Science; Mechanics
GA EB6XO
UT WOS:000387529100005
ER
PT J
AU Haque, A
Scultetus, AH
Arnaud, F
Dickson, LJ
Chun, S
McNamee, G
Auker, CR
McCarron, RM
Mahon, RT
AF Haque, Ashraful
Scultetus, Anke H.
Arnaud, Francoise
Dickson, Leonora J.
Chun, Steve
McNamee, George
Auker, Charles R.
McCarron, Richard M.
Mahon, Richard T.
TI The Emulsified PFC Oxycyte(A (R)) Improved Oxygen Content and Lung
Injury Score in a Swine Model of Oleic Acid Lung Injury (OALI)
SO LUNG
LA English
DT Article
DE Acute respiratory distress syndrome (ARDS); Tissue oxygenation;
Perfluorocarbon (PFC); Oleic acid (OA); Resuscitation and oleic
acid-induced lung injury (OALI)
ID RESPIRATORY-DISTRESS-SYNDROME; PERFLUOROCARBON EMULSIONS; TISSUE
OXYGENATION; MECHANISM; DELIVERY; BLOOD; IDENTIFICATION; HEMODILUTION;
DEFINITION; COMPLEMENT
AB Perfluorocarbons (PFCs) can transport 50 times more oxygen than human plasma. Their properties may be advantageous in preservation of tissue viability in oxygen-deprived states, such as in acute lung injury. We hypothesized that an intravenous dose of the PFC emulsion Oxycyte(A (R)) would improve tissue oxygenation and thereby mitigate the effects of acute lung injury.
Intravenous oleic acid (OA) was used to induce lung injury in anesthetized and instrumented Yorkshire swine assigned to three experimental groups: (1) PFC post-OA received Oxycyte(A (R)) (5 ml/kg) 45 min after oleic acid-induced lung injury (OALI); (2) PFC pre-OA received Oxycyte(A (R)) 45 min before OALI; and (3) Controls which received equivalent dose of normal saline. Animals were observed for 3 h after OALI began, and then euthanized.
The median survival times for PFC post-OA, PFC pre-OA, and control were 240, 87.5, and 240 min, respectively (p = 0.001). Mean arterial pressure and mean pulmonary arterial pressure were both higher in the PFC post-OA (p < 0.001 for both parameters). Oxygen content was significantly different between PFC post-OA and the control (p = 0.001). Histopathological grading of lung injury indicated that edema and congestion was significantly less severe in the PFC post-OA compared to control (p = 0.001).
The intravenous PFC Oxycyte(A (R)) improves blood oxygen content and lung histology when used as a treatment after OALI, while Oxycyte(A (R)) used prior to OALI was associated with increased mortality. Further exploration in other injury models is indicated.
C1 [Haque, Ashraful; Scultetus, Anke H.; Arnaud, Francoise; Chun, Steve; Auker, Charles R.; McCarron, Richard M.] Naval Med Res Ctr, NeuroTrauma Dept, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
[Scultetus, Anke H.; Arnaud, Francoise; McNamee, George; McCarron, Richard M.] Uniformed Serv Univ Hlth Sci, Dept Surg, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.
[Dickson, Leonora J.] Walter Reed Army Inst Res, Dept Pathol, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
[Chun, Steve] Walter Reed Natl Mil Med Ctr, Dept Surg, 8901 Rockville Pike, Bethesda, MD 20889 USA.
[Mahon, Richard T.] Naval Med Res Ctr, Undersea Med Dept, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
RP Haque, A (reprint author), Naval Med Res Ctr, NeuroTrauma Dept, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM ashraful.haque.ctr@mail.mil; anke.h.scultetus2.ctr@mail.mil;
francoise.arnaud.ctr@mail.mil; leonora.j.dickson.mil@mail.mil;
steve.j.chun.mil@mail.mil; george.a.mcnamee.civ@mail.mil;
charles.r.auker.ctr@mail.mil; richard.m.mccarron.civ@mail.mil;
richard.t.mahon4.ctr@mail.mil
FU U.S. Army Defense Health Program [60115HP.3720.001.A1016]
FX This work was funded by the U.S. Army Defense Health Program through
work unit #60115HP.3720.001.A1016.
NR 31
TC 0
Z9 0
U1 5
U2 5
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0341-2040
EI 1432-1750
J9 LUNG
JI Lung
PD DEC
PY 2016
VL 194
IS 6
BP 945
EP 957
DI 10.1007/s00408-016-9941-9
PG 13
WC Respiratory System
SC Respiratory System
GA EB4RP
UT WOS:000387361100010
PM 27704259
ER
PT J
AU Habtour, E
Cole, DP
Riddick, JC
Weiss, V
Robeson, M
Sridharan, R
Dasgupta, A
AF Habtour, Ed
Cole, Daniel P.
Riddick, Jaret C.
Weiss, Volker
Robeson, Mark
Sridharan, Raman
Dasgupta, Abhijit
TI Detection of fatigue damage precursor using a nonlinear vibration
approach
SO STRUCTURAL CONTROL & HEALTH MONITORING
LA English
DT Article
DE damage detection; high cycle fatigue; nonlinear vibration; damage
precursor
ID CRACK DETECTION; MECHANICAL-PROPERTIES; CANTILEVER BEAM; LUMPED MASS;
NANOINDENTATION; FREQUENCY; BEHAVIOR; COMPOSITES; EXCITATION; HARVESTERS
AB A nonlinear dynamic methodology is developed for detecting and estimating fatigue damage precursor in isotropic metal structures, prior to fatigue crack initiation, based on measurement of changes in the structure nonlinear response to harmonic base excitation. As an example, a damage precursor feature was extracted for cantilever beams by quantifying the reduction in the nonlinear stiffness because of localized microscopic material softening. The nonlinear dynamic analytical model parametrically tracks changes in the nonlinear structural stiffening as a function of the structural response and the loading cycles. Experimental results are obtained by exciting the base of cantilever beams at various amplitude levels. At high response amplitudes, the beams experience three competing simultaneous nonlinear dynamic mechanisms: (i) stiffening because of high response amplitude at the fundamental mode; (ii) softening because of inertial forces; and (iii) softening because of localized microscopic material damage caused by cyclic micro-plasticity. The third mechanisma potential precursor to fatigue crack initiation in the structureresulted in a cumulative softening because of early accumulation of cyclic fatigue damage and is the focus of this study. The loading intensity and the number of cycles influenced the relative contribution of these dynamic mechanisms. Nanoindentation studies near the beam clamped boundary were conducted to confirm the fatigue degradation in the local mechanical properties as a function of loading cycles. The proposed detection method is simple to implement and detects the presence of damage precursors but lacks the resolution to discern spatial distributions of the damage intensity. Based on prior knowledge of the structural dynamic characteristics of the beam and using the proposed methodology, damage level and stiffness reduction can be detected and estimated based on changes in the nonlinear structural response. The nonlinear stiffness term in the equation of motion is found to be very sensitive to the proposed fatigue damage precursor, making it an effective method for monitoring structural degradation prior to crack developments. The proposed methodology provides new insights and constitutes a significant step toward the development of new inspection techniques. Copyright (c) 2016 John Wiley & Sons, Ltd.
C1 [Habtour, Ed; Cole, Daniel P.; Riddick, Jaret C.; Weiss, Volker] US Army Res Lab, Vehicle Technol Directorate, Aberdeen Proving Ground, MD 21005 USA.
[Robeson, Mark] US Army Aviat & Missile Res Dev & Engn Ctr, Aviat Dev Directorate, Aviat Appl Technol Directorate, Ft Eustis, VA 23604 USA.
[Sridharan, Raman; Dasgupta, Abhijit] Univ Maryland, Ctr Adv Life Cycle Engn, College Pk, MD 20742 USA.
RP Habtour, E (reprint author), US Army Res Lab, RDRL VTM, 4603 Flare Loop, Aberdeen Proving Ground, MD 21005 USA.
EM ed.m.habtour.civ@mail.mil
FU Center for Advanced Life Cycle Engineering at the University of
Maryland; Collaborative Research and Development Agreement; US Army
Research Laboratory (ARL); University of Maryland under the ARL
Open-Campus Initiative
FX This research effort was funded by the sponsors of the Center for
Advanced Life Cycle Engineering at the University of Maryland and was
further supported by a Collaborative Research and Development Agreement
between the US Army Research Laboratory (ARL) and the University of
Maryland under the ARL Open-Campus Initiative.
NR 63
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U1 9
U2 9
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1545-2255
EI 1545-2263
J9 STRUCT CONTROL HLTH
JI Struct. Control. Health Monit.
PD DEC
PY 2016
VL 23
IS 12
BP 1442
EP 1463
DI 10.1002/stc.1844
PG 22
WC Construction & Building Technology; Engineering, Civil; Instruments &
Instrumentation
SC Construction & Building Technology; Engineering; Instruments &
Instrumentation
GA EB4HP
UT WOS:000387331900004
ER
PT J
AU Markwalter, CF
Ricks, KM
Bitting, AL
Mudenda, L
Wright, DW
AF Markwalter, Christine F.
Ricks, Keersten M.
Bitting, Anna L.
Mudenda, Lwiindi
Wright, David W.
TI Simultaneous capture and sequential detection of two malarial biomarkers
on magnetic microparticles
SO TALANTA
LA English
DT Article
DE Immunoassay; Malaria; Plasmodium lactate dehydrogenase; Plasmodium
falciparum histidine-rich protein II
ID HISTIDINE-RICH PROTEIN-2; RAPID DIAGNOSTIC-TEST; LACTATE-DEHYDROGENASE;
IMMUNOASSAY; PERFORMANCE; ELISA
AB We have developed a rapid magnetic microparticle-based detection strategy for malarial biomarkers Plasmodium lactate dehydrogenase (pLDH) and Plasmodium falciparum histidine-rich protein II (PfHRPII). In this assay, magnetic particles functionalized with antibodies specific for pLDH and PfHRPII as well as detection antibodies with distinct enzymes for each biomarker are added to parasitized lysed blood samples. Sandwich complexes for pLDH and pfHRPII form on the surface of the magnetic beads, which are washed and sequentially re-suspended in detection enzyme substrate for each antigen. The developed simultaneous capture and sequential detection (SCSD) assay detects both biomarkers in samples as low as 2.0 parasites/mu l, an order of magnitude below commercially available ELISA kits, has a total incubation time of 35 min, and was found to be reproducible between users over time. This assay provides a simple and efficient alternative to traditional 96-well plate ELISAs, which take 5-8 h to complete and are limited to one analyte. Further, the modularity of the magnetic bead-based SCSD ELISA format could serve as a platform for application to other diseases for which multi-biomarker detection is advantageous. (C) 2016 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.orgilicensesiby/4.0/).
C1 [Markwalter, Christine F.; Ricks, Keersten M.; Bitting, Anna L.; Mudenda, Lwiindi; Wright, David W.] Vanderbilt Univ, Dept Chem, Stn B 351822, Nashville, TN 37235 USA.
[Ricks, Keersten M.] US Army, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
RP Wright, DW (reprint author), Vanderbilt Univ, Dept Chem, Stn B 351822, Nashville, TN 37235 USA.
EM david.wright@vanderbilt.edu
FU Bill and Melinda Gates Foundation Grand Challenges in Global Health
Diagnostics [OPP 1028749]; PATH: Diagnostics for malaria elimination
toward eradication [1758-00-06-00]; NIH/Fogarty International Center
[D43 TW009348]; Vanderbilt University through the Laboratories for
Innovation in Global Health Technologies; National Science Foundation
Graduate Research Fellowship program [1445197, 0909667]
FX This work was supported by the Bill and Melinda Gates Foundation Grand
Challenges in Global Health Diagnostics (OPP 1028749), PATH: Diagnostics
for malaria elimination toward eradication (1758-00-06-00), NIH/Fogarty
International Center (D43 TW009348), and Vanderbilt University through
the Laboratories for Innovation in Global Health Technologies. This
material is based on work supported by the National Science Foundation
Graduate Research Fellowship program under Grants 1445197 (C.F.M and
K.M.R.) and 0909667 (K.M.R.). The authors thank M.F. Richards for
critical comments in the preparation of this manuscript.
NR 20
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U1 11
U2 11
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0039-9140
EI 1873-3573
J9 TALANTA
JI Talanta
PD DEC 1
PY 2016
VL 161
BP 443
EP 449
DI 10.1016/j.talanta.2016.08.078
PG 7
WC Chemistry, Analytical
SC Chemistry
GA EA9UF
UT WOS:000386989500056
PM 27769430
ER
PT J
AU Chen, Z
Kecskes, LJ
Zhu, KG
Wei, QM
AF Chen, Zhe
Kecskes, Laszlo J.
Zhu, Kaigui
Wei, Qiuming
TI Atomistic simulations of the effect of embedded hydrogen and helium on
the tensile properties of monocrystalline and nanocrystalline tungsten
SO JOURNAL OF NUCLEAR MATERIALS
LA English
DT Article
DE Molecular dynamics; Tungsten; Plasma facing materials; Irradiation;
Tension
ID MOLECULAR-DYNAMICS SIMULATIONS; LOW-ENERGY; BUBBLE FORMATION; ULTRAFINE
GRAIN; HIGH-FLUX; IRRADIATION; METALS; PLASMA; RETENTION; DIFFUSION
AB Uniaxial tensile properties of monocrystalline tungsten (MC-W) and nanocrystalline tungsten (NC-W) with embedded hydrogen and helium atoms have been investigated using molecular dynamics (MD) simulations in the context of radiation damage evolution. Different strain rates have been imposed to investigate the strain rate sensitivity (SRS) of the samples. Results show that the plastic deformation processes of MC-W and NC-W are dominated by different mechanisms, namely dislocation-based for MC-W and grain boundary-based activities for NC-W, respectively. For MC-W, the SRS increases and a transition appears in the deformation mechanism with increasing embedded atom concentration. However, no obvious embedded atom concentration dependence of the SRS has been observed for NC-W. Instead, in the latter case, the embedded atoms facilitate GB sliding and intergranular fracture. Additionally, a strong strain enhanced He cluster growth has been observed. The corresponding underlying mechanisms are discussed. (C) 2016 Elsevier B.V. All rights reserved.
C1 [Chen, Zhe; Zhu, Kaigui] Beihang Univ, Dept Phys, Beijing 100191, Peoples R China.
[Kecskes, Laszlo J.] US Army Res Lab, Aberdeen, MD 21005 USA.
[Chen, Zhe; Wei, Qiuming] Univ North Carolina Charlotte, Dept Mech Engn, Charlotte, NC 28223 USA.
[Zhu, Kaigui] Beihang Univ, Beijing Key Lab Adv Nucl Energy Mat & Phys, Beijing 100191, Peoples R China.
RP Zhu, KG (reprint author), Beihang Univ, Dept Phys, Beijing 100191, Peoples R China.; Wei, QM (reprint author), Univ North Carolina Charlotte, Dept Mech Engn, Charlotte, NC 28223 USA.
EM kgzhu@buaa.edu.cn; qwei@uncc.edu
RI Wei, Qiuming/B-7579-2008
FU National Magnetic Confinement Fusion Programs [2015GB1019003,
2013GB109003]; National Natural Science Foundation of China [51471015,
51171006]; Chinese Scholar Council (CSC); U.S. Army Research Laboratory
[W911NF-14-2-0061]
FX This work is supported by National Magnetic Confinement Fusion Programs
with Grant No. 2015GB1019003 and 2013GB109003, National Natural Science
Foundation of China with Grant No. 51471015 and No. 51171006. Z. Chen
would like to acknowledge the support from Chinese Scholar Council (CSC)
for his visit to UNC-Charlotte. Q. Wei is supported by U.S. Army
Research Laboratory under Contract No. W911NF-14-2-0061.
NR 66
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U1 17
U2 17
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0022-3115
EI 1873-4820
J9 J NUCL MATER
JI J. Nucl. Mater.
PD DEC
PY 2016
VL 481
BP 190
EP 200
DI 10.1016/j.jnucmat.2016.09.024
PG 11
WC Materials Science, Multidisciplinary; Nuclear Science & Technology
SC Materials Science; Nuclear Science & Technology
GA EA7PF
UT WOS:000386822900022
ER
PT J
AU Koppenhaver, S
Embry, R
Ciccarello, J
Waltrip, J
Pike, R
Walker, M
Fernandez-de-las-Penas, C
Croy, T
Flynn, T
AF Koppenhaver, Shane
Embry, Robin
Ciccarello, John
Waltrip, Justin
Pike, Rachel
Walker, Michael
Fernandez-de-las-Penas, Cesar
Croy, Theodore
Flynn, Timothy
TI Effects of dry needling to the symptomatic versus control shoulder in
patients with unilateral subacromial pain syndrome
SO MANUAL THERAPY
LA English
DT Article
DE Trigger point; Dry needling; Muscle function; Shoulder pain; Ultrasound
imaging
ID MYOFASCIAL TRIGGER POINTS; LUMBAR MULTIFIDUS MUSCLES; TRANSVERSUS
ABDOMINIS; PRESSURE ALGOMETRY; NECK PAIN; RELIABILITY; MANAGEMENT;
MOTION; RANGE; IRRITABILITY
AB Background: Initial reports suggest that treating myofascial trigger points in the infraspinatus with dry needling may be effective in treating patients with shoulder pain. However, to date, high quality clinical trials and thorough knowledge of the physiologic mechanisms involved is lacking.
Objectives: To examine the effect of dry needling to the infraspinatus muscle on muscle function, nociceptive sensitivity, and shoulder range of motion (ROM) in the symptomatic and asymptomatic shoulders of individuals with unilateral subacromial pain syndrome.
Design: Within-subjects controlled trial.
Methods: Fifty-seven volunteers with unilateral subacromial pain syndrome underwent one session of dry needling to bilateral infraspinatus muscles. Outcome assessments, including ultrasonic measures of infraspinatus muscle thickness, pressure algometry, shoulder internal rotation and horizontal adduction ROM, and questionnaires regarding pain and related disability were taken at baseline, immediately after dry needling, and 3-4 days later.
Results: Participants experienced statistically significant and clinically relevant changes in all self-report measures. Pressure pain threshold and ROM significantly increased 3-4 days, but not immediately after dry needling only in the symptomatic shoulder [Pressure pain threshold: 5.1 (2.2, 8.0) N/cm(2), internal rotation ROM: 9.6 (5.0, 14.1) degrees, horizontal adduction ROM: 5.9 (2.5, 9.4) degrees]. No significant changes occurred in resting or contracted infraspinatus muscle thickness in either shoulder.
Conclusions: This study found changes in shoulder ROM and pain sensitivity, but not in muscle function, after dry needling to the infraspinatus muscle in participants with unilateral subacromial pain syndrome. These changes generally occurred 3-4 days after dry needling and only in the symptomatic shoulders. Published by Elsevier Ltd.
C1 [Koppenhaver, Shane; Embry, Robin; Ciccarello, John; Waltrip, Justin; Pike, Rachel; Croy, Theodore] US Army, Baylor Univ Doctoral Program Phys Therapy, San Antonio, TX 78220 USA.
[Koppenhaver, Shane; Walker, Michael; Flynn, Timothy] South Coll Doctor Phys Therapy Program, Knoxville, TN USA.
[Fernandez-de-las-Penas, Cesar] URJC, Dept Phys Therapy Occupat Therapy Phys Med & Reha, Madrid, Spain.
RP Koppenhaver, S (reprint author), US Army, Baylor Univ Doctoral Program Phys Therapy, San Antonio, TX 78220 USA.
EM shanekoppenhaver@mac.com
NR 45
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Z9 0
U1 6
U2 6
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 1356-689X
EI 1532-2769
J9 MANUAL THER
JI Man. Ther.
PD DEC
PY 2016
VL 26
BP 62
EP 69
DI 10.1016/j.math.2016.07.009
PG 8
WC Rehabilitation
SC Rehabilitation
GA EA4RL
UT WOS:000386601600011
PM 27497188
ER
PT J
AU Felt, D
Gurtowski, L
Nestler, CC
Johnson, J
Larson, S
AF Felt, Deborah
Gurtowski, Luke
Nestler, Catherine C.
Johnson, Jared
Larson, Steven
TI A two-stage extraction procedure for insensitive munition (IM) explosive
compounds in soils
SO CHEMOSPHERE
LA English
DT Article
DE Insensitive munitions (IM); Soil extraction; Method; DNAN; NQ; NTO; RDX;
TNT; Silt; Sandy clay; Clay; Nitroaromatic munitions; Nitramine
munitions
ID PERFORMANCE LIQUID-CHROMATOGRAPHY; 3-NITRO-1,2,4-TRIAZOL-5-ONE NTO;
2,4-DINITROANISOLE DNAN; ENERGETIC MATERIALS; DISSOLUTION;
NITROGUANIDINE; DECOMPOSITION; CONSTITUENTS; WATER
AB The Department of Defense (DoD) is developing a new category of insensitive munitions (IMs) that are more resistant to detonation or promulgation from external stimuli than traditional munition formulations. The new explosive constituent compounds are 2,4-dinitroanisole (DNAN), nitroguanidine (NQ), and nitrotriazolone (NTO). The production and use of IM formulations may result in interaction of IM component compounds with soil. The chemical properties of these IM compounds present unique challenges for extraction from environmental matrices such as soil. A two-stage extraction procedure was developed and tested using several soil types amended with known concentrations of IM compounds. This procedure incorporates both an acidified phase and an organic phase to account for the chemical properties of the IM compounds. The method detection limits (MDLs) for all IM compounds in all soil types were <5 mg/kg and met non-regulatory risk-based Regional Screening Level (RSL) criteria for soil proposed by the U.S. Army Public Health Center. At defined environmentally relevant concentrations, the average recovery of each IM compound in each soil type was consistent and greater than 85%. The two-stage extraction method decreased the influence of soil composition on IM compound recovery. UV analysis of NTO established an isosbestic point based on varied pH at a detection wavelength of 341 nm. The two-stage soil extraction method is equally effective for traditional munition compounds, a potentially important point when examining soils exposed to both traditional and insensitive munitions. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Felt, Deborah; Gurtowski, Luke; Johnson, Jared; Larson, Steven] US Army, Engn Res & Dev Ctr, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
[Nestler, Catherine C.] Appl Res Associates Inc, 119 Monument Pl, Vicksburg, MS 39180 USA.
RP Felt, D (reprint author), US Army, Engn Res & Dev Ctr, Environm Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
EM Deborah.Felt@usace.army.mil
FU Environmental Quality/Installations Program, U.S. Army Engineer Research
and Development Center (ERDC)
FX This work was funded by the Environmental Quality/Installations Program,
U.S. Army Engineer Research and Development Center (ERDC). Analytical
and technical support was provided by Christine Miller and Daisha Floyd
of the ERDC - Environmental Laboratory. Citation of trade names used in
this manuscript does not constitute an official endorsement or approval
of the use of such commercial products. This manuscript was approved for
public release by the Chief of Engineers.
NR 37
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U1 12
U2 12
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0045-6535
EI 1879-1298
J9 CHEMOSPHERE
JI Chemosphere
PD DEC
PY 2016
VL 165
BP 18
EP 26
DI 10.1016/j.chemosphere.2016.08.098
PG 9
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA EA2DE
UT WOS:000386402200003
PM 27619644
ER
PT J
AU Farbaniec, L
Williams, CL
Kecskes, L
Ramesh, KT
Becker, R
AF Farbaniec, L.
Williams, C. L.
Kecskes, L.
Ramesh, K. T.
Becker, R.
TI Microstructural effects on the spall properties of ECAE-processed AZ31B
magnesium alloy
SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING
LA English
DT Article
DE Spall experiment; Recovery experiment; Microstructural
characterizations; Nucleation site; Mg alloys
ID MECHANICAL-PROPERTIES; GRAIN-SIZE; BEHAVIOR; DEFORMATION; SHOCK;
EVOLUTION; DEPENDENCE
AB Time-resolved normal plate impact experiments and spall recovery experiments were conducted to study the spall behavior of AZ31B-4E magnesium alloy processed via Equal-Channel Angular Extrusion (ECAE). The spall strength and incipient spall damage in the specimens were measured at different shock stresses using 51 mm and 105 mm bore gas guns. The Hugoniot Elastic Limit (HEL) was measured to be approximately 181 +/- 3 MPa. The spall strengths extracted from the free surface velocity profiles of the shocked specimens were found to decrease by 5% for shock stresses ranging from 1.7 GPa to 4.6 GPa. However, this reduction in spall strength may fall within the experimental error. Post-test fractographic examinations of recovered specimens revealed that spall failure originated at micrometer-size intermetallic inclusions and propagated through the material by cavitation events with a very limited growth of voids. It was concluded that the strengthening of AZ31B-4E magnesium alloy by the ECAE-process resulted in adverse effects on its microstructure and spall behavior because of the process-induced cracking of intermetallic inclusions and their weak interface strengths. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Farbaniec, L.; Ramesh, K. T.] Johns Hopkins Univ, Hopkins Extreme Mat Inst, Baltimore, MD 21218 USA.
[Farbaniec, L.] Imperial Coll London, Inst Shock Phys, London SW7 2AZ, England.
[Williams, C. L.; Kecskes, L.; Becker, R.] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA.
[Ramesh, K. T.] Johns Hopkins Univ, Dept Mech Engn, Baltimore, MD 21218 USA.
RP Farbaniec, L (reprint author), Imperial Coll London, Inst Shock Phys, London SW7 2AZ, England.
EM l.farbaniec@imperial.ac.uk
FU Army Research Laboratory [W911NF-12-2-0022]
FX This work was sponsored by the Army Research Laboratory and was
accomplished under Cooperative Agreement Number W911NF-12-2-0022. The
views and conclusions contained in this document are those of the
authors and should not be interpreted as representing the official
policies, either expressed or implied, of the Army Research Laboratory
or the U.S. Government. The U.S. Government is authorized to reproduce
and distribute reprints for Government purposes notwithstanding any
copyright notation herein.
NR 33
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U1 13
U2 13
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0734-743X
EI 1879-3509
J9 INT J IMPACT ENG
JI Int. J. Impact Eng.
PD DEC
PY 2016
VL 98
BP 34
EP 41
DI 10.1016/j.ijimpeng.2016.08.001
PG 8
WC Engineering, Mechanical; Mechanics
SC Engineering; Mechanics
GA EA2IK
UT WOS:000386415800004
ER
PT J
AU Li, QH
Ural, S
Anderson, J
Shan, J
AF Li, Qinghua
Ural, Serkan
Anderson, John
Shan, Jie
TI A Fuzzy Mean-Shift Approach to Lidar Waveform Decomposition
SO IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING
LA English
DT Article
DE Classification; fuzzy algorithm; LiDAR; mean-shift; waveform
decomposition
ID LASER SCANNER; CALIBRATION; BATHYMETRY; FEATURES
AB Waveform decomposition is a common step for exploitation of full-waveform lidar data. Much effort has been focused on designing algorithms based on the assumption that the returned waveforms follow a Gaussian mixture model where each component is a Gaussian. However, many real examples show that the waveform components can be neither Gaussian nor symmetric even when the emitted signal is Gaussian or symmetric. This paper proposes a nonparametric mixture model to represent lidar waveforms without any constraints on the shape of the waveform components. A fuzzy mean-shift algorithm is then developed to decompose the waveforms. This approach has the following properties: 1) It does not assume that the waveforms follow any parametric or functional distributions; 2) the waveform decomposition is treated as a fuzzy data clustering problem and the number of components is determined during the time of decomposition; and 3) neither peak selection nor noise floor filtering prior to the decomposition is needed. Experiments are conducted on a dataset collected over a dense forest area where significant skewed waveforms are demonstrated. As the result of the waveform decomposition, a highly dense point cloud is generated, followed by a subsequent filtering step to create a fine digital elevation model. Compared with the conventional expectation-maximization method, the fuzzy mean-shift approach yielded practically comparable and similar results. However, it is about three times faster and tends to lead to slightly fewer artifacts in the resultant digital elevation model.
C1 [Li, Qinghua; Ural, Serkan; Shan, Jie] Purdue Univ, Lyles Sch Civil Engn, W Lafayette, IN 47907 USA.
[Anderson, John] US Army, Engn Res & Dev Ctr, Corps Engineers, Washington, DC 20314 USA.
RP Shan, J (reprint author), Purdue Univ, Lyles Sch Civil Engn, W Lafayette, IN 47907 USA.
EM li975@purdue.edu; sural@purdue.edu; jshan@purdue.edu
RI Ural, Serkan/G-6128-2013
OI Ural, Serkan/0000-0002-8522-5975
FU U.S. Army Research Office
FX This work was supported in part by the U.S. Army Research Office.
(Corresponding author: Jie Shan.)
NR 41
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U1 10
U2 10
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 0196-2892
EI 1558-0644
J9 IEEE T GEOSCI REMOTE
JI IEEE Trans. Geosci. Remote Sensing
PD DEC
PY 2016
VL 54
IS 12
BP 7112
EP 7121
DI 10.1109/TGRS.2016.2596105
PG 10
WC Geochemistry & Geophysics; Engineering, Electrical & Electronic; Remote
Sensing; Imaging Science & Photographic Technology
SC Geochemistry & Geophysics; Engineering; Remote Sensing; Imaging Science
& Photographic Technology
GA DZ2ZW
UT WOS:000385713500024
ER
PT J
AU Dalyander, PS
Meyers, M
Mattsson, B
Steyer, G
Godsey, E
McDonald, J
Byrnes, M
Ford, M
AF Dalyander, P. Soupy
Meyers, Michelle
Mattsson, Brady
Steyer, Gregory
Godsey, Elizabeth
McDonald, Justin
Byrnes, Mark
Ford, Mark
TI Use of structured decision-making to explicitly incorporate
environmental process understanding in management of coastal restoration
projects: Case study on barrier islands of the northern Gulf of Mexico
SO JOURNAL OF ENVIRONMENTAL MANAGEMENT
LA English
DT Article
DE Structured decision-making; Ecosystem restoration; Adaptive management;
Mississippi Coastal Improvements Program; Gulf of Mexico; Barrier
islands
ID BAYESIAN NETWORK; EXTREME STORMS; EVOLUTION; MODELS; CHAIN
AB Coastal ecosystem management typically relies on subjective interpretation of scientific understanding, with limited methods for explicitly incorporating process knowledge into decisions that must meet multiple, potentially competing stakeholder objectives. Conversely, the scientific community lacks methods for identifying which advancements in system understanding would have the highest value to decision-makers. A case in point is barrier island restoration, where decision-makers lack tools to objectively use system understanding to determine how to optimally use limited contingency funds when project construction in this dynamic environment does not proceed as expected. In this study, collaborative structured decision-making (SDM) was evaluated as an approach to incorporate process understanding into mid-construction decisions and to identify priority gaps in knowledge from a management perspective. The focus was a barrier island restoration project at Ship Island, Mississippi, where sand will be used to close an extensive breach that currently divides the island. SDM was used to estimate damage that may occur during construction, and guide repair decisions within the confines of limited availability of sand and funding to minimize adverse impacts to project objectives. Sand was identified as more limiting than funds, and unrepaired major breaching would negatively impact objectives. Repairing minor damage immediately was determined to be generally more cost effective (depending on the longshore extent) than risking more damage to a weakened project. Key gaps in process-understanding relative to project management were identified as the relationship of island width to breach formation; the amounts of sand lost during breaching, lowering, or narrowing of the berm; the potential for minor breaches to self-heal versus developing into a major breach; and the relationship between upstream nourishment and resiliency of the berm to storms. This application is a prototype for using structured decision-making in support of engineering projects in dynamic environments where mid-construction decisions may arise; highlights uncertainty about barrier island physical processes that limit the ability to make robust decisions; and demonstrates the potential for direct incorporation of process-based models in a formal adaptive management decision framework. Published by Elsevier Ltd.
C1 [Dalyander, P. Soupy] US Geol Survey, St Petersburg Coastal & Marine Sci Ctr, 600 4th St S, St Petersburg, FL 33701 USA.
[Meyers, Michelle] US Geol Survey, Natl Wetlands Res Ctr, 700 Cajundome Blvd, Lafayette, LA USA.
[Mattsson, Brady] Univ Nat Resources & Life Sci Vienna, Gregor Mendel Str 33, A-1180 Vienna, Austria.
[Steyer, Gregory] US Geol Survey, Livestock Show Off, Baton Rouge, LA USA.
[Godsey, Elizabeth; McDonald, Justin] US Army Corps Engineers, 109 St Joseph St, Mobile, AL USA.
[Byrnes, Mark] Appl Coastal Res & Engn, 766 Falmouth Rd,Suite A-1, Mashpee, MA USA.
[Ford, Mark] Natl Pk Serv, Southeast Reg Off, New Orleans, LA USA.
RP Dalyander, PS (reprint author), US Geol Survey, St Petersburg Coastal & Marine Sci Ctr, 600 4th St S, St Petersburg, FL 33701 USA.
EM sdalyander@usgs.gov; mmeyers@usgs.gov; brady.mattsson@boku.ac.at;
gsteyer@usgs.gov; Elizabeth.S.Godsey@usace.army.mil;
Justin.S.McDonald@usace.army.mil; mbyrnes@appliedcoastal.com;
mark_ford@nps.gov
OI Dalyander, P. Soupy/0000-0001-9583-0872
FU Department of the Interior Southeast Climate Science Center
FX We would like to thank the project team including Darin Lee, Nate
Lovelace, and Ayse Karanci for their participation and expertise. We
also want to thank Elise Irwin for her SDM expertise, including helping
to facilitate the prototyping workshops and for her instrumental
guidance and participation through the project. We are grateful to the
respective agencies of the coauthors and the project participants
(USACE, USGS, NPS, LA CPRA, Applied Coastal Inc.) in allocating the time
for participants to engage in the effort, webinars and workshops, and to
complete the project. We thank Alyssa Dausman for helping to identify
and invite project participants and organizing the first workshop, and
Holly Beck documenting the outcomes from the second stakeholder meeting.
We also thank Linda Barnett for information regarding species habitat
and for her review and Susan Rees for her feedback throughout the
project. Thanks to Nathaniel Plant for additional insight on the role
and context of science-based decision support in coastal environments.
Funding was provided by the Department of the Interior Southeast Climate
Science Center; however, the findings and conclusions in this article do
not necessarily represent the views of the Southeast Climate Science
Center. Any use of trade, firm, or product names is for descriptive
purposes only and does not imply endorsement by the U.S. Government.
NR 39
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U1 24
U2 24
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 0301-4797
EI 1095-8630
J9 J ENVIRON MANAGE
JI J. Environ. Manage.
PD DEC 1
PY 2016
VL 183
BP 497
EP 509
DI 10.1016/j.jenvman.2016.08.078
PN 3
PG 13
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA DZ5KC
UT WOS:000385900000007
PM 27623362
ER
PT J
AU Mrozek, RA
Gold, CS
Leighliter, B
Sietins, JM
Lenhart, JL
AF Mrozek, Randy A.
Gold, Christopher S.
Leighliter, Brad
Sietins, Jennifer M.
Lenhart, Joseph L.
TI Open pore, elastomeric scaffolds through frustrated particle collapse
SO JOURNAL OF MATERIALS SCIENCE
LA English
DT Article
ID INDUCED PHASE-SEPARATION; HIGH-FLOW CHARACTERISTICS;
MECHANICAL-PROPERTIES; CARBON NANOTUBES; BLOCK-COPOLYMERS; MACROPOROUS
POLYMERS; COMPOSITE SCAFFOLDS; POROUS MATERIALS; SILICA AEROGELS;
SURFACE-AREA
AB This article describes a procedure for making open cell porous elastomeric polymer composites with pore volumes from 40 to 68 vol%, particle loadings up to 49 vol%, and high exposed particle surface area to provide opportunities for multifunctionality. The method exploits particle packing limitations to provide the porous structure during solvent extraction from a melt extrudable solvent-loaded polymer gel composite. During the solvent extraction process, the composite contracts, concentrating the particles, which reduces the interparticle spacing until adjacent particles are nearly in contact. Further solvent removal after particle concentration results in polymer fibrillation and void formation. The final porosity of the composites is dependent on the particle packing efficiency with estimated pore volumes ranging from 39 to 43 vol% for spherical particles to 68 vol% for higher aspect ratio particles. In addition, the particles can be dissolved from the scaffold to leave the unfilled porous elastomer, or partially dissolved to generate a core-shell structure with an outer continuous porosity layer void of particulate surrounding a particle laden porous core. While solvent removal from the gel composite is required, the method does not require the use of a blowing agent, phase separation, or a sacrificial particulate porogen to generate an open porous composite. In addition, the solvent minimizes the viscosity rise associated with high particulate loadings to maintain the ability to melt process the material. It is anticipated that this method of generating open pore composites with available particle surface area will provide opportunities for novel catalyst supports, tissue engineering scaffolds, mass transport applications, and mechanically tailorable materials.
C1 [Mrozek, Randy A.; Gold, Christopher S.; Leighliter, Brad; Sietins, Jennifer M.; Lenhart, Joseph L.] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RP Mrozek, RA; Lenhart, JL (reprint author), US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA.
EM randy.a.mrozek.civ@mail.mil; Christoper.Gold@dupot.com;
BLeighliter@oh.hra.com; jennifer.m.sietins.civ@mail.mil;
joseph.l.lenhart.civ@mail.mil
NR 55
TC 0
Z9 0
U1 11
U2 11
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0022-2461
EI 1573-4803
J9 J MATER SCI
JI J. Mater. Sci.
PD DEC
PY 2016
VL 51
IS 24
BP 10761
EP 10774
DI 10.1007/s10853-016-0288-7
PG 14
WC Materials Science, Multidisciplinary
SC Materials Science
GA DY8VT
UT WOS:000385410400006
ER
PT J
AU Brunye, TT
Moran, JM
Houck, LA
Taylor, HA
Mahoney, CR
AF Brunye, Tad T.
Moran, Joseph M.
Houck, Lindsay A.
Taylor, Holly A.
Mahoney, Caroline R.
TI Registration errors in beacon-based navigation guidance systems:
Influences on path efficiency and user reliance
SO INTERNATIONAL JOURNAL OF HUMAN-COMPUTER STUDIES
LA English
DT Article
DE Navigation; Augmented cognition; Trust in automation; Perception-action;
Virtual environments
ID AUGMENTED REALITY; AUTOMATION; TRUST; HUMANS; ATTENTION; DESIGN; MEMORY;
MAPS; AIDS
AB Emerging augmented reality displays provide high fidelity overlays onto real-world environments to enable navigation efficiency. The accuracy of these systems, however, is highly contingent on monitoring and registering user orientations and landmark locations. No data exist, however, regarding ranges at which registration error reliably influences user behavior and trust. The present experiments examined the influence of directional error in a simulated navigation guidance system on path efficiency and user trust. In three experiments, participants (N=90) navigated an urban desktop virtual environment with the assistance of an overlaid beacon depicting the direction and distance of a target landmark. Directional error was introduced into the beacon across trials, manipulated in 15 degrees increments from 0 degrees to 60 degrees (Experiment 1), 5 degrees increments from 0 degrees to 20 degrees (Experiment 2), and 1 increments from 6 degrees to 10 degrees (Experiment 3). Users show tolerance for up to approximately 8 degrees angular direction error without significantly reducing path efficiency or user trust in system reliability. They also show reduced path efficiency emerging at lower angular errors (approximately 9 degrees) relative to influences on perceived trust (approximately 16-20 degrees). Results provide some basic heuristics for error tolerance, demonstrate important dissociations between the objective versus perceived impact of error in navigation displays, and contribute to theoretical positions regarding the optimization of global awareness and spatial knowledge acquisition. Published by Elsevier Ltd.
C1 [Brunye, Tad T.; Moran, Joseph M.; Houck, Lindsay A.; Mahoney, Caroline R.] US Army Natick Soldier Res, Cognit Sci Team, Ctr Dev & Engn, 15 Kansas St, Natick, MA 01760 USA.
[Brunye, Tad T.; Moran, Joseph M.; Houck, Lindsay A.; Taylor, Holly A.; Mahoney, Caroline R.] Ctr Appl Brain & Cognit Sci, 200 Boston Ave, Medford, MA 02155 USA.
[Brunye, Tad T.; Taylor, Holly A.] Tufts Univ, Dept Psychol, 490 Boston Ave, Medford, MA 02155 USA.
RP Brunye, TT (reprint author), Ctr Appl Brain & Cognit Sci, 200 Boston Ave, Medford, MA 02155 USA.
EM tbruny01@tufts.edu
FU U.S. Army Natick Soldier Research, Development, and Engineering Center
[W911QY-13-C-0012]
FX We wish to thank Mr. Brian Westgate for programming the computerized
navigation task. This project was supported by a grant awarded to H.A.T.
from the U.S. Army Natick Soldier Research, Development, and Engineering
Center (W911QY-13-C-0012). Permission was granted by the U.S. Army
Natick Soldier RDEC to publish this material. The views expressed in
this article are solely those of the authors and do not reflect the
official policies or positions of the Department of Army, the Department
of Defense, or any other department or agency of the U.S. government.
NR 54
TC 1
Z9 1
U1 12
U2 12
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1071-5819
EI 1095-9300
J9 INT J HUM-COMPUT ST
JI Int. J. Hum.-Comput. Stud.
PD DEC
PY 2016
VL 96
BP 1
EP 11
DI 10.1016/j.ijhcs.2016.07.008
PG 11
WC Computer Science, Cybernetics; Ergonomics; Psychology, Multidisciplinary
SC Computer Science; Engineering; Psychology
GA DY1OR
UT WOS:000384864800001
ER
PT J
AU Kalambate, PK
Rawool, CR
Karna, SP
Srivastava, AK
AF Kalambate, Pramod K.
Rawool, Chaitali R.
Karna, Shashi P.
Srivastava, Ashwini K.
TI Highly sensitive and selective determination of methylergometrine
maleate using carbon nanofibers/silver nanoparticles composite modified
carbon paste electrode
SO MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
LA English
DT Article
DE Methylergometrine maleate; Carbon nanofibers; Silver nanoparticles;
Differential pulse voltammetry
ID DIFFERENTIAL-PULSE VOLTAMMETRY; SILVER NANOPARTICLES; METHYLERGONOVINE
MALEATE; ERGONOVINE MALEATE; ERGOT ALKALOIDS; PERFORMANCE; METHYSERGIDE;
SUPERCAPACITORS; NANOCOMPOSITE; INJECTIONS
AB A highly sensitive and selective voltammetric method for determination of Methylergometrine maleate (MM) in pharmaceutical formulations, urine and blood serum samples has been developed based on enhanced electrochemical response of MM at carbon nanofibers and silver nanoparticles modified carbon paste electrode (CNF-AgNP-CPE). The electrode material was characterized by various techniques viz., X-ray diffraction, scanning electron microscopy and energy dispersive X-ray spectroscopy. The electrocatalytic response of MM at CNF-AgNP-CPE was studied by cyclic voltammetry (CV), differential pulse voltammetry (DPV) and electrochemical impedance spectroscopy (EIS). Under optimized conditions, the proposed sensor exhibits excellent electrochemical response towards MM. The DPV study shows greatly enhanced electrochemical signal for MM at CNF-AgNPCPE lending high sensitivity to the proposed sensor for MM detection. The peak (I-p) current for MM is found to be rectilinear in the range 4.0 x 10(-8)-2.0 x 10(-5) M with a detection limit of 7.1 x 10(-9) M using DPV. The feasibility of the proposed sensor in analytical applications was investigated by conducting experiments on commercial pharmaceutical formulations, human urine and blood serum samples, which yielded satisfactory recoveries of MM. The proposed electrochemical sensor offers high sensitivity, selectivity, reproducibility and practical utility. We recommend it as an authentic and productive electrochemical sensor for successful determination of MM. (C) 2016 Published by Elsevier B.V.
C1 [Kalambate, Pramod K.; Rawool, Chaitali R.; Srivastava, Ashwini K.] Univ Bombay, Dept Chem, Bombay 400098, Maharashtra, India.
[Karna, Shashi P.] US Army Res Lab, Weap & Mat Res Directorate, ATTN RDRL WM, Aberdeen Proving Ground, MD 21005 USA.
RP Srivastava, AK (reprint author), Univ Bombay, Dept Chem, Bombay 400098, Maharashtra, India.
EM aksrivastava@chem.mu.ac.in
FU University Grant Commission, New Delhi, India [UGC/X-PGR23]
FX The funding for this work is by the University Grant Commission, New
Delhi, India under the University with potential for excellence scheme
to University of Mumbai (Grant number: UGC/X-PGR23). The authors wish to
acknowledge National Centre for Nanoscience and Nanotechnology,
University of Mumbai for providing SEM facility.
NR 36
TC 0
Z9 0
U1 35
U2 35
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0928-4931
EI 1873-0191
J9 MAT SCI ENG C-MATER
JI Mater. Sci. Eng. C-Mater. Biol. Appl.
PD DEC 1
PY 2016
VL 69
BP 453
EP 461
DI 10.1016/j.msec.2016.06.077
PG 9
WC Materials Science, Biomaterials
SC Materials Science
GA DW8UL
UT WOS:000383930900054
PM 27612735
ER
PT J
AU Moskowitz, IS
Hyden, P
Russell, S
AF Moskowitz, Ira S.
Hyden, Paul
Russell, Stephen
TI Network topology and mean infection times
SO SOCIAL NETWORK ANALYSIS AND MINING
LA English
DT Article
DE Social network; Centrality; SIR; Spectral radius
ID SOCIAL NETWORKS; INFORMATION DIFFUSION; CENTRALITY
AB A fundamental concept of social network analysis is centrality. Many analyses represent the network topology in terms of concept transmission/variation, e.g., influence, social structure, community or other aggregations. Even when the temporal nature of the network is considered, analysis is conducted at discrete points along a continuous temporal scale. Unfortunately, well-studied metrics of centrality do not take varying probabilities into account. The assumption that social and other networks that may be physically stationary, e.g., hard wired, are conceptually static in terms of information diffusion or conceptual aggregation (communities, etc.) can lead to incorrect conclusions. Our findings illustrate, both mathematically and experimentally, that if the notion of network topology is not stationary or fixed in terms of the concept, e.g., groups, belonging, community or other aggregations, centrality should be viewed probabilistically. We show through some surprising examples that study of transmission behavior based solely on a graph's topological and degree properties is lacking when it comes to modeling network propagation or conceptual (vs. physical) structure.
C1 [Moskowitz, Ira S.; Hyden, Paul] Naval Res Lab, Informat Management & Decis Architectures Branch, Code 5580, Washington, DC 20375 USA.
[Russell, Stephen] US Army, Res Lab, Battlefield Informat Proc Branch, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
RP Moskowitz, IS (reprint author), Naval Res Lab, Informat Management & Decis Architectures Branch, Code 5580, Washington, DC 20375 USA.
EM ira.moskowitz@nrl.navy.mil
NR 44
TC 0
Z9 0
U1 4
U2 4
PU SPRINGER WIEN
PI WIEN
PA SACHSENPLATZ 4-6, PO BOX 89, A-1201 WIEN, AUSTRIA
SN 1869-5450
EI 1869-5469
J9 SOC NETW ANAL MIN
JI Soc. Netw. Anal. Min.
PD DEC
PY 2016
VL 6
IS 1
AR UNSP 34
DI 10.1007/s13278-016-0338-9
PG 14
WC Computer Science, Information Systems
SC Computer Science
GA DT1CY
UT WOS:000381220500034
ER
PT J
AU Schrock, JA
Hirsch, EA
Lacouture, S
Kelley, MD
Bilbao, AV
Ray, WB
Bayne, SB
Giesselmann, M
O'Brien, H
Ogunniyi, A
AF Schrock, James A.
Hirsch, Emily A.
Lacouture, Shelby
Kelley, Mitchell D.
Bilbao, Argenis V.
Ray, William B.
Bayne, Stephen B.
Giesselmann, Michael
O'Brien, Heather
Ogunniyi, Aderinto
TI Failure Modes of 15-kV SiC SGTO Thyristors During Repetitive Extreme
Pulsed Overcurrent Conditions
SO IEEE TRANSACTIONS ON POWER ELECTRONICS
LA English
DT Article
DE Failure modes; pulsed overcurrent; scanning electron microscope (SEM);
SiC; thyristor
ID POWER DEVICES; CONVERTER; SYSTEMS; VOLTAGE; TIME; TEMPERATURE; INVERTER;
IGCT
AB SiC SGTO thyristors are an advanced solution for increasing the power density of medium voltage power electronics. However, for these devices to replace Si thyristor technology in industrial applications their characteristics and failure modes must be understood. This letter presents the failure modes of two 15-kV SiC SGTO thyristors during repetitive overcurrent conditions. The devices were evaluated with 2-kA (3.85 kA/cm(2)) square pulses of 100 mu s duration using a pulse forming network. Throughout testing, each devices' static characteristics were analyzed for signs of degradation; upon degradation, testing was ceased and the physical failure mode was determined through imaging with a scanning electron microscope (SEM) in conjunction with a focused ion beam. The electrical results demonstrate the failure modes of both SiC SGTO thyristors during pulsed overcurrents electrically manifested themselves as a conductive path through the gate-anode junction and an increased device on-state voltage. SEM imaging revealed one SiC thyristor formed an approximately 10-mu m wide cylindrical void, and the second SiC thyristor formed an approximately 200-mu m long crack. However, the experimental results demonstrate these 15-kV SiC SGTO thyristors' robust ability to repetitively switch at extreme high current density for tens of thousands of cycles.
C1 [Schrock, James A.; Hirsch, Emily A.; Lacouture, Shelby; Kelley, Mitchell D.; Bilbao, Argenis V.; Ray, William B.; Bayne, Stephen B.; Giesselmann, Michael] Texas Tech Univ, Pulsed Power & Power Elect, Lubbock, TX 79409 USA.
[O'Brien, Heather; Ogunniyi, Aderinto] US Army, Res Lab, Adelphi, MD 20783 USA.
RP Hirsch, EA (reprint author), Texas Tech Univ, Pulsed Power & Power Elect, Lubbock, TX 79409 USA.
EM emily.hirsch@ttu.edu; shelby.lacouture@ttu.edu; mitchell.kelley@ttu.edu;
argenis.bilbao@ttu.edu; w.ray@ttu.edu; stephen.bayne@ttu.edu;
michael.giesselmann@ttu.edu; heather.k.obrien.civ@mail.mil;
aderinto.a.ogunniyi.civ@mail.mil
NR 29
TC 0
Z9 0
U1 48
U2 48
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 0885-8993
EI 1941-0107
J9 IEEE T POWER ELECTR
JI IEEE Trans. Power Electron.
PD DEC
PY 2016
VL 31
IS 12
BP 8058
EP 8062
DI 10.1109/TPEL.2016.2574625
PG 5
WC Engineering, Electrical & Electronic
SC Engineering
GA DR7YW
UT WOS:000380116600008
ER
PT J
AU Hill, A
Gerras, S
AF Hill, Andrew
Gerras, Stephen
TI SYSTEMS OF DENIAL Strategic Resistance to Military Innovation
SO NAVAL WAR COLLEGE REVIEW
LA English
DT Article
C1 [Hill, Andrew] US Army War Coll, Dept Command Leadership & Management, Org Studies, Carlisle, PA 17013 USA.
[Gerras, Stephen] US Army War Coll, Dept Command Leadership & Management, Behav Sci, Carlisle, PA USA.
RP Hill, A (reprint author), US Army War Coll, Dept Command Leadership & Management, Org Studies, Carlisle, PA 17013 USA.
NR 38
TC 0
Z9 0
U1 9
U2 9
PU US NAVAL WAR COLL
PI NEWPORT
PA 686 CUSHING RD, NEWPORT, RI 02841 USA
SN 0028-1484
J9 NAV WAR COLL REV
JI Nav. War Coll. Rev.
PD WIN
PY 2016
VL 69
IS 1
BP 109
EP 132
PG 24
WC International Relations
SC International Relations
GA DP3ZZ
UT WOS:000378436400007
ER
PT J
AU Kuehn, JT
AF Kuehn, John T.
TI Beyond Air-Sea Battle: The Debate over US Military Strategy in Asia
SO NAVAL WAR COLLEGE REVIEW
LA English
DT Book Review
C1 [Kuehn, John T.] US Army Command & Gen Staff Coll, Hist Res, Ft Leavenworth, KS 66027 USA.
RP Kuehn, JT (reprint author), US Army Command & Gen Staff Coll, Hist Res, Ft Leavenworth, KS 66027 USA.
NR 1
TC 0
Z9 0
U1 2
U2 2
PU US NAVAL WAR COLL
PI NEWPORT
PA 686 CUSHING RD, NEWPORT, RI 02841 USA
SN 0028-1484
J9 NAV WAR COLL REV
JI Nav. War Coll. Rev.
PD WIN
PY 2016
VL 69
IS 1
BP 159
EP 161
PG 3
WC International Relations
SC International Relations
GA DP3ZZ
UT WOS:000378436400013
ER
PT J
AU Schifferle, PJ
AF Schifferle, Peter J.
TI Command Culture: Officer Education in the U.S. Army and the German Armed
Forces, 1901-1940, and the Consequences for World War II
SO NAVAL WAR COLLEGE REVIEW
LA English
DT Book Review
C1 [Schifferle, Peter J.] US Army Command & Gen Staff Coll, Sch Adv Mil Studies, Hist, Ft Leavenworth, KS 66027 USA.
RP Schifferle, PJ (reprint author), US Army Command & Gen Staff Coll, Sch Adv Mil Studies, Hist, Ft Leavenworth, KS 66027 USA.
NR 1
TC 0
Z9 0
U1 59
U2 59
PU US NAVAL WAR COLL
PI NEWPORT
PA 686 CUSHING RD, NEWPORT, RI 02841 USA
SN 0028-1484
J9 NAV WAR COLL REV
JI Nav. War Coll. Rev.
PD WIN
PY 2016
VL 69
IS 1
BP 164
EP 166
PG 3
WC International Relations
SC International Relations
GA DP3ZZ
UT WOS:000378436400016
ER
PT J
AU Terrill, WA
AF Terrill, W. Andrew
TI The Iran-Iraq War: A Military and Strategic History
SO MIDDLE EAST JOURNAL
LA English
DT Book Review
C1 [Terrill, W. Andrew] US Army War Coll, Strateg Studies Inst, Carlisle, PA 17013 USA.
RP Terrill, WA (reprint author), US Army War Coll, Strateg Studies Inst, Carlisle, PA 17013 USA.
NR 1
TC 0
Z9 0
U1 5
U2 9
PU MIDDLE EAST INST
PI WASHINGTON
PA 1761 N ST NW, CIRCULATION DEPT, WASHINGTON, DC 20036-2882 USA
SN 0026-3141
EI 1940-3461
J9 MIDDLE EAST J
JI Middle East J.
PD WIN
PY 2016
VL 70
IS 1
BP 168
EP 169
PG 2
WC Area Studies
SC Area Studies
GA DC1FC
UT WOS:000368961200023
ER
PT J
AU Talin, AA
Ruzmetov, D
Kolmakov, A
McKelvey, K
Ware, N
El Gabaly, F
Dunn, B
White, HS
AF Talin, A. Alec
Ruzmetov, Dmitry
Kolmakov, Andrei
McKelvey, Kim
Ware, Nicholas
El Gabaly, Farid
Dunn, Bruce
White, Henry S.
TI Fabrication, Testing, and Simulation of All-Solid-State
Three-Dimensional Li-Ion Batteries
SO ACS APPLIED MATERIALS & INTERFACES
LA English
DT Article
DE solid-state battery; three-dimensional; thin film; inhomogeneity;
experiment and modeling
ID LITHIUM BATTERIES; MICROBATTERIES; ARRAYS; CATHODES; LICOO2
AB Demonstration of three-dimensional all-solid-state Li-ion batteries (3D SSLIBs) has been a long-standing goal for numerous researchers in the battery community interested in developing high power and high areal energy density storage solutions for a variety of applications. Ideally, the 3D geometry maximizes the volume of active material per unit area, while keeping its thickness small to allow for fast Li diffusion. In this paper, we describe experimental testing and simulation of 3D SSLIBs fabricated using materials and thin-film deposition methods compatible with semiconductor device processing. These 3D SSLIBs consist of Si microcolumns onto which the battery layers are sequentially deposited using physical vapor deposition. The power performance of the 3D SSLIBs lags significantly behind that of similarly prepared planar SSLIBs. Analysis of the experimental results using finite element modeling indicates that the origin of the poor power performance is the structural inhomogeneity of the 3D SSLIB, coupled with low electrolyte ionic conductivity and diffusion rate in the cathode, which lead to highly nonuniform internal current density distribution and poor cathode utilization.
C1 [Talin, A. Alec; El Gabaly, Farid] Sandia Natl Labs, Livermore, CA 94551 USA.
[Ruzmetov, Dmitry; Kolmakov, Andrei] NIST, Ctr Nanoscale Sci & Technol, Gaithersburg, MD 20899 USA.
[McKelvey, Kim; White, Henry S.] Univ Utah, Dept Chem, Salt Lake City, UT 84112 USA.
[Ware, Nicholas; Dunn, Bruce] Univ Calif Los Angeles, Dept Mat Sci & Engn, Los Angeles, CA 90095 USA.
[Ruzmetov, Dmitry] US Army Res Lab, Adelphi, MD USA.
RP Talin, AA (reprint author), Sandia Natl Labs, Livermore, CA 94551 USA.
EM aatalin@sandia.gov
RI Kolmakov, Andrei/B-1460-2017
OI Kolmakov, Andrei/0000-0001-5299-4121
FU Science of Precision Multifunctional Nanostructures for Electrical
Energy Storage (NEES), an Energy Frontier Research Center - U.S. DOE,
Office of Science, Office of Basic Energy Sciences [DESC0001160];
University of Maryland [70NANB10H193]; National Institute of Standards
and Technology Center for Nanoscale Science and Technology
[70NANB10H193]; U.S. Department of Energy's National Nuclear Security
Administration [DE-AC04-94AL85000]
FX A.A.T., KM., N.W., F.E.G., B.D., and H.S.W. were supported by the
Science of Precision Multifunctional Nanostructures for Electrical
Energy Storage (NEES), an Energy Frontier Research Center funded by the
U.S. DOE, Office of Science, Office of Basic Energy Sciences, under
award DESC0001160. The authors acknowledge CNST NIST NanoFab personnel
for help in fabrications and tests of the 3D batteries. D.R acknowledges
support under the Cooperative Research Agreement between the University
of Maryland and the National Institute of Standards and Technology
Center for Nanoscale Science and Technology, Award 70NANB10H193, through
the University of Maryland. Sandia National Laboratories is a
multiprogram laboratory managed and operated by Sandia Corporation, a
wholly owned subsidiary of Lockheed Martin Corporation, for the U.S.
Department of Energy's National Nuclear Security Administration under
contract DE-AC04-94AL85000.
NR 18
TC 0
Z9 0
U1 56
U2 56
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1944-8244
J9 ACS APPL MATER INTER
JI ACS Appl. Mater. Interfaces
PD NOV 30
PY 2016
VL 8
IS 47
BP 32385
EP 32391
DI 10.1021/acsami.6b12244
PG 7
WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary
SC Science & Technology - Other Topics; Materials Science
GA ED9AF
UT WOS:000389161600033
PM 27933836
ER
PT J
AU Cong, Y
Dyall, J
Hart, BJ
DeWald, LE
Johnson, JC
Postnikova, E
Zhou, H
Gross, R
Rojas, O
Alexander, I
Josleyn, N
Zhang, T
Michelotti, J
Janosko, K
Glass, PJ
Flint, M
McMullan, LK
Spiropoulou, CF
Mierzwa, T
Guha, R
Shinn, P
Michael, S
Klumpp-Thomas, C
McKnight, C
Thomas, C
Eakin, AE
O'Loughlin, KG
Green, CE
Catz, P
Mirsalis, JC
Honko, AN
Olinger, GG
Bennett, RS
Holbrook, MR
Hensley, LE
Jahrling, PB
AF Cong, Yu
Dyall, Julie
Hart, Brit J.
DeWald, Lisa Evans
Johnson, Joshua C.
Postnikova, Elena
Zhou, Huanying
Gross, Robin
Rojas, Oscar
Alexander, Isis
Josleyn, Nicole
Zhang, Tengfei
Michelotti, Julia
Janosko, Krisztina
Glass, Pamela J.
Flint, Mike
McMullan, Laura K.
Spiropoulou, Christina F.
Mierzwa, Tim
Guha, Rajarshi
Shinn, Paul
Michael, Sam
Klumpp-Thomas, Carleen
McKnight, Crystal
Thomas, Craig
Eakin, Ann E.
O'Loughlin, Kathleen G.
Green, Carol E.
Catz, Paul
Mirsalis, Jon C.
Honko, Anna N.
Olinger, Gene G., Jr.
Bennett, Richard S.
Holbrook, Michael R.
Hensley, Lisa E.
Jahrling, Peter B.
TI Evaluation of the Activity of Lamivudine and Zidovudine against Ebola
Virus
SO PLOS ONE
LA English
DT Article
ID REVERSE-TRANSCRIPTASE; CELL-LINES; MACROPHAGES; 5'-TRIPHOSPHATE;
GLYCOPROTEINS; PATHOGENESIS; PREVENTION; DIAGNOSIS; SYNERGY; ENTRY
AB In the fall of 2014, an international news agency reported that patients suffering from Ebola virus disease (EVD) in Liberia were treated successfully with lamivudine, an antiviral drug used to treat human immunodeficiency virus-1 and hepatitis B virus infections. According to the report, 13 out of 15 patients treated with lamivudine survived and were declared free from Ebola virus disease. In this study, the anti-Ebola virus (EBOV) activity of lamivudine and another antiretroviral, zidovudine, were evaluated in a diverse set of cell lines against two variants of wild-type EBOV. Variable assay parameters were assessed to include different multiplicities of infection, lengths of inoculation times, and durations of dosing. At a multiplicity of infection of 1, lamivudine and zidovudine had no effect on EBOV propagation in Vero E6, Hep G2, or HeLa cells, or in primary human monocyte-derived macrophages. At a multiplicity of infection of 0.1, zidovudine demonstrated limited anti-EBOV activity in Huh 7 cells. Under certain conditions, lamivudine had low anti-EBOV activity at the maximum concentration tested (320 mu M). However, lamivudine never achieved greater than 30% viral inhibition, and the activity was not consistently reproducible. Combination of lamivudine and zidovudine showed no synergistic antiviral activity. Independently, a set of in vitro experiments testing lamivudine and zidovudine for antiviral activity against an Ebolaen-hanced green fluorescent protein reporter virus was performed at the Centers for Disease Control and Prevention. No antiviral activity was observed for either compound. A study evaluating the efficacy of lamivudine in a guinea pig model of EVD found no survival benefit. This lack of benefit was observed despite plasma lamivudine concentrations in guinea pig of about 4 mu g/ml obtained in a separately conducted pharmacokinetics study. These studies found no evidence to support the therapeutic use of lamivudine for the treatment of EVD.
C1 [Cong, Yu; Dyall, Julie; Hart, Brit J.; DeWald, Lisa Evans; Johnson, Joshua C.; Postnikova, Elena; Zhou, Huanying; Gross, Robin; Rojas, Oscar; Alexander, Isis; Josleyn, Nicole; Zhang, Tengfei; Michelotti, Julia; Janosko, Krisztina; Honko, Anna N.; Olinger, Gene G., Jr.; Bennett, Richard S.; Holbrook, Michael R.; Hensley, Lisa E.; Jahrling, Peter B.] NIAID, Div Clin Res, Integrated Res Facil, NIH, Frederick, MD 21702 USA.
[Josleyn, Nicole; Glass, Pamela J.] US Army, Med Res Inst Infect Dis, Frederick, MD USA.
[Flint, Mike; McMullan, Laura K.; Spiropoulou, Christina F.] Ctr Dis Control & Prevent, Viral Special Pathogens Branch, Div High Consequence Pathogens & Pathol, Atlanta, GA USA.
[Mierzwa, Tim; Guha, Rajarshi; Shinn, Paul; Michael, Sam; Klumpp-Thomas, Carleen; McKnight, Crystal; Thomas, Craig] NIH, Natl Ctr Adv Translat Sci, Bldg 10, Bethesda, MD 20892 USA.
[Eakin, Ann E.] NIAID, Off Biodef Res Resources & Translat Res, Div Microbiol & Infect Dis, NIH, Rockville, MD USA.
[O'Loughlin, Kathleen G.; Green, Carol E.; Catz, Paul; Mirsalis, Jon C.] SRI Int, 333 Ravenswood Ave, Menlo Pk, CA 94025 USA.
[Jahrling, Peter B.] NIAID, Emerging Viral Pathogens Sect, NIH, Frederick, MD USA.
[Hart, Brit J.] Assoc Publ Hlth Abstract Labs, Silver Spring, MD USA.
[Zhang, Tengfei] Thermo Fisher Sci Inc, Frederick, MD USA.
RP Dyall, J (reprint author), NIAID, Div Clin Res, Integrated Res Facil, NIH, Frederick, MD 21702 USA.
EM dyallj@niaid.nih.gov
OI Honko, Anna/0000-0001-9165-148X
FU SRI International
FX SRI International provided support in the form of salaries for authors
[KGO, PC, CEG, JCM], but did not have any additional role in the study
design, data collection and analysis, decision to publish, or
preparation of the manuscript. The specific roles of these authors are
articulated in the 'author contributions' section.; We thank IRF Cell
Culture staff in preparing the cells used in this study. We appreciate
the strong support from Will Sheffield from NCI-Frederick research donor
program and Linda Coe (IRF) in obtaining fresh human blood from NIH
blood bank (Bethesda, MD, USA). We thank Dr. Gary Kobinger (Public
Health Agency of Canada, Winnipeg, CA) for the Makona variant of EBOV
(GenBank accession no. KP096420). We thank Dr. Thomas Geisbert
(University of Texas Medical Branch at Galveston, Galveston, TX, USA)
for the Hartley guinea pig adapted variant of EBOV. We thank Dr.
Atsunobu Hiraoka (SCGF Research Laboratory, Kyoto, JP) for the kind gift
of conditioned medium from KPB-M15 cells. We thank Dr. Hideki Ebihara
(NIAID, Rocky Mountain Laboratories, Hamilton, MT) for Huh 7 (human
hepatocellular carcinoma) cells. We thank Dr. William Eugene Dowling
(Division of Microbiology and Infectious Diseases, NIH) for providing
resources for the pharmacokinetic study. We thank Linh Nguyen and Julie
Nop for expert technical assistance in the conduct of the
pharmacokinetics study. In addition, we acknowledge Laura Bollinger and
Jiro Wada at the IRF for technical writing services and figure
preparation, respectively, for this manuscript.
NR 34
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PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD NOV 30
PY 2016
VL 11
IS 11
AR e0166318
DI 10.1371/journal.pone.0166318
PG 19
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA EE3FV
UT WOS:000389474100019
PM 27902714
ER
PT J
AU Donald, W
Pasay, C
Guintran, JO
Iata, H
Anderson, K
Nausien, J
Gresty, KJ
Waters, NC
Vestergaard, LS
Taleo, G
Cheng, Q
AF Donald, Wesley
Pasay, Cielo
Guintran, Jean-Olivier
Iata, Harry
Anderson, Karen
Nausien, Johnny
Gresty, Karryn J.
Waters, Norman C.
Vestergaard, Lasse S.
Taleo, George
Cheng, Qin
TI The Utility of Malaria Rapid Diagnostic Tests as a Tool in Enhanced
Surveillance for Malaria Elimination in Vanuatu
SO PLOS ONE
LA English
DT Article
ID REACTIVE CASE DETECTION; SYMPTOMATIC MALARIA; AMPLIFICATION KIT;
PLASMODIUM-VIVAX; INFECTIONS; PREVALENCE; PARASITE; ISLANDS; ZAMBIA;
AREAS
AB Background
As part of efforts to eliminate malaria, Vanuatu has piloted the implementation of enhanced malaria surveillance and response strategies since 2011. This involves passive case detection (PCD) in health facilities, proactive case detection (Pro-ACD) and reactive case detection (Re-ACD) in communities using malaria rapid diagnostic tests (RDTs). While RDTs improve case management, their utility for detection of malaria infections in ACDs in this setting is unclear.
Methods
The utility of malaria RDTs as diagnostic tools was evaluated in PCD, in five rounds of Pro-ACDs and five rounds of Re-ACDs conducted in Tafea and Torba Provinces between 2011 and 2014. The number of malaria infections detected by RDTs was compared to that detected by PCR from collected used-RDTs.
Results
PCD in Tafea Province (2013) showed a RDT-positive rate of 0.21% (2/939) and a PCR-positive rate of 0.44% (2/453), indicating less than 1% of suspected malaria cases in Tafea Province were due to malaria. In Pro-ACDs conducted in Tafea and Torba Provinces, RDT-positive rates in 2013 and 2014 were 0.14% (3/2145) and 0% (0/2823), respectively, while the corresponding PCR-positive rates were 0.72% (9/1242) and 0.79% (9/1141). PCR identified villages in both provinces appearing to be transmission foci with a small number of low-density infections, mainly P. falciparum infections. In five rounds of Re-ACD, RDTs did not identify any additional infections while PCR detected only one among 173 subjects screened.
Conclusions
PCD and Pro-ACDs demonstrate that both Tafea and Torba Provinces in Vanuatu has achieved very low malaria prevalence. In these low-transmission areas, conducting Pro-ACD and Re-ACDs using RDTs appears not cost-effective and may have limited impact on interrupting malaria transmission due to the small number of infections identified by RDTs and considerable operational resources invested. More sensitive, field deployable and affordable diagnostic tools will improve malaria surveillance in malaria elimination settings.
C1 [Donald, Wesley; Iata, Harry; Nausien, Johnny; Taleo, George] Minist Hlth, Malaria & Vector Borne Dis Control, Port Vila, Vanuatu.
[Pasay, Cielo; Anderson, Karen; Gresty, Karryn J.; Cheng, Qin] Australian Army Malaria Inst, Drug Resistance & Diagnost, Brisbane, Qld, Australia.
[Pasay, Cielo; Anderson, Karen; Gresty, Karryn J.; Cheng, Qin] QIMR Berghofer Med Res Inst, Clin Trop Med, Brisbane, Qld, Australia.
[Guintran, Jean-Olivier] WHO, Vanuatu Country Off, Port Vila, Vanuatu.
[Waters, Norman C.] Walter Reed Army Inst Res, Malaria Vaccine Branch, Mil Malaria Res Program, Silver Spring, MD USA.
[Vestergaard, Lasse S.] WHO, Western Pacific Reginal Off, Manila, Philippines.
RP Taleo, G (reprint author), Minist Hlth, Malaria & Vector Borne Dis Control, Port Vila, Vanuatu.; Cheng, Q (reprint author), Australian Army Malaria Inst, Drug Resistance & Diagnost, Brisbane, Qld, Australia.; Cheng, Q (reprint author), QIMR Berghofer Med Res Inst, Clin Trop Med, Brisbane, Qld, Australia.
EM gtaleo@vanuatu.gov.au; qin.cheng@defence.gov.au
FU AusAID through the Pacific Malaria Initiative Supporting Centre,
University of Queensland; Department of Defense, Global Emerging
Infections Surveillance Program (DoD-GETS), United States
FX The work was partially funded by: AusAID through the Pacific Malaria
Initiative Supporting Centre, University of Queensland and the
Department of Defense, Global Emerging Infections Surveillance Program
(DoD-GETS), United States.
NR 36
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PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD NOV 30
PY 2016
VL 11
IS 11
AR e0167136
DI 10.1371/journal.pone.0167136
PG 14
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA EE3FV
UT WOS:000389474100055
PM 27902755
ER
PT J
AU Hartley, DJ
Janssens, RVF
Riedinger, LL
Riley, MA
Wang, X
Miller, SL
Ayangeakaa, AD
Bertone, PF
Carpenter, MP
Chiara, CJ
Chowdhury, P
Garg, U
Gurdal, G
Hota, SS
Kondev, FG
Lauritsen, T
Ma, WC
Matta, J
McCutchan, EA
Mukhopadhyay, S
Pedicini, EE
Vanhoy, JR
Zhu, S
AF Hartley, D. J.
Janssens, R. V. F.
Riedinger, L. L.
Riley, M. A.
Wang, X.
Miller, S. L.
Ayangeakaa, A. D.
Bertone, P. F.
Carpenter, M. P.
Chiara, C. J.
Chowdhury, P.
Garg, U.
Gurdal, G.
Hota, S. S.
Kondev, F. G.
Lauritsen, T.
Ma, W. C.
Matta, J.
McCutchan, E. A.
Mukhopadhyay, S.
Pedicini, E. E.
Vanhoy, J. R.
Zhu, S.
TI First observation of rotational structures in Re-168
SO PHYSICAL REVIEW C
LA English
DT Article
ID DOUBLY ODD NUCLEI; SIGNATURE INVERSION; COINCIDENCE DATA; TRIAXIALITY;
DECAY
AB The first rotational sequences have been assigned to the odd-odd nucleus Re-168. Coincidence relationships of these structures with rhenium x rays confirm the isotopic assignment, while arguments based on the gamma-ray multiplicity (K-fold) distributions observed with the new bands lead to the mass assignment. Configurations for the two bands were determined through analysis of the rotational alignments of the structures and a comparison of the experimental B(M1)/B(E2) ratios with theory. Tentative spin assignments are proposed for the pi h(11/2)nu i(13/2) band, based on energy level systematics for other known sequences in neighboring odd-odd rhenium nuclei, as well as on systematics seen for the signature inversion feature that is well known in this region. The spin assignment for the pi h(11/2)nu(h(9/2)/f(7/2)) structure provides additional validation of the proposed spins and configurations for isomers in the Au-176 -> Ir-172 -> Re-168 alpha-decay chain.
C1 [Hartley, D. J.; Pedicini, E. E.; Vanhoy, J. R.; Zhu, S.] US Naval Acad, Dept Phys, Annapolis, MD 21402 USA.
[Janssens, R. V. F.; Ayangeakaa, A. D.; Bertone, P. F.; Carpenter, M. P.; Chiara, C. J.; Lauritsen, T.; McCutchan, E. A.] Argonne Natl Lab, Div Phys, Argonne, IL 60439 USA.
[Riedinger, L. L.] Univ Tennessee, Dept Phys & Astron, Knoxville, TN 37996 USA.
[Riley, M. A.; Wang, X.; Miller, S. L.] Florida State Univ, Dept Phys, Tallahassee, FL 32306 USA.
[Ayangeakaa, A. D.; Garg, U.; Matta, J.; Mukhopadhyay, S.] Univ Notre Dame, Dept Phys, Notre Dame, IN 46556 USA.
[Chiara, C. J.] Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA.
[Chiara, C. J.; Gurdal, G.; Kondev, F. G.] Argonne Natl Lab, Nucl Engn Div, 9700 S Cass Ave, Argonne, IL 60439 USA.
[Chowdhury, P.; Hota, S. S.] Univ Massachusetts Lowell, Dept Phys, Lowell, MA 01854 USA.
[Ma, W. C.] Mississippi State Univ, Dept Phys, Mississippi State, MS 39762 USA.
[Wang, X.] Calif Polytech State Univ San Luis Obispo, Dept Phys, San Luis Obispo, CA 93407 USA.
[Bertone, P. F.] Marshall Space Flight Ctr, Huntsville, AL 35812 USA.
[Chiara, C. J.] US Army, Res Lab, Adelphi, MD 20783 USA.
[Gurdal, G.] Millsaps Coll, Dept Phys, Jackson, MS 39210 USA.
[Hota, S. S.] Australian Natl Univ, Dept Nucl Phys, RSPE, Canberra, ACT 2601, Australia.
[Matta, J.] Oak Ridge Natl Lab, Div Phys, Oak Ridge, TN 37831 USA.
[McCutchan, E. A.] Brookhaven Natl Lab, Natl Nucl Data Ctr, Upton, NY 11973 USA.
[Mukhopadhyay, S.] Bhabha Atom Res Ctr, Div Nucl Phys, Mumbai 400085, Maharashtra, India.
RP Hartley, DJ (reprint author), US Naval Acad, Dept Phys, Annapolis, MD 21402 USA.
FU National Science Foundation [PHY-1203100, PHY-0754674, PHY10-68192]; US
Department of Energy, Office of Nuclear Physics [DE-AC02-06CH11357,
DE-FG02-94ER40848, DE-FG02-96ER40983, DE-FG02-95ER40939,
DE-FG02-94ER40834]
FX The authors thank the ANL operations staff at Gammasphere and gratefully
acknowledge the efforts of J. P. Greene for target preparation. We thank
D. C. Radford and H. Q. Jin for their software support. This work is
funded by the National Science Foundation under GrantS No. PHY-1203100
(USNA), No. PHY-0754674 (FSU), and No. PHY10-68192 (ND), as well as by
the US Department of Energy, Office of Nuclear Physics, under Contracts
No. DE-AC02-06CH11357 (ANL), No. DE-FG02-94ER40848 (UML), No.
DE-FG02-96ER40983 (UT), No. DE-FG02-95ER40939 (MSU), and No.
DE-FG02-94ER40834 (UMCP). This research used resources of Argonne
National Laboratory's ATLAS facility, which is a DOE Office of Science
User Facility.
NR 22
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U1 2
U2 2
PU AMER PHYSICAL SOC
PI COLLEGE PK
PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA
SN 2469-9985
EI 2469-9993
J9 PHYS REV C
JI Phys. Rev. C
PD NOV 30
PY 2016
VL 94
IS 5
AR 054329
DI 10.1103/PhysRevC.94.054329
PG 7
WC Physics, Nuclear
SC Physics
GA ED4ML
UT WOS:000388822700002
ER
PT J
AU Samuel, GH
Wiley, MR
Badawi, A
Adelman, ZN
Myles, KM
AF Samuel, Glady Hazitha
Wiley, Michael R.
Badawi, Atif
Adelman, Zach N.
Myles, Kevin M.
TI Yellow fever virus capsid protein is a potent suppressor of RNA
silencing that binds double-stranded RNA
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
AMERICA
LA English
DT Article
DE yellow fever virus; flavivirus; capsid; Zika virus; RNA interference
ID BORNE ENCEPHALITIS-VIRUS; DENGUE VIRUS; CORE PROTEIN; 3-DIMENSIONAL
ARCHITECTURE; ANTIVIRAL IMMUNITY; SUBVIRAL PARTICLES; RISC ACTIVATION;
INITIATION STEP; FLAVIVIRUS RNA; MOSQUITO CELLS
AB Mosquito-borne flaviviruses, including yellow fever virus (YFV), Zika virus (ZIKV), and West Nile virus (WNV), profoundly affect human health. The successful transmission of these viruses to a human host depends on the pathogen's ability to overcome a potentially sterilizing immune response in the vector mosquito. Similar to other invertebrate animals and plants, the mosquito's RNA silencing pathway comprises its primary antiviral defense. Although a diverse range of plant and insect viruses has been found to encode suppressors of RNA silencing, the mechanisms by which flaviviruses antagonize antiviral small RNA pathways in disease vectors are unknown. Here we describe a viral suppressor of RNA silencing (VSR) encoded by the prototype flavivirus, YFV. We show that the YFV capsid (YFC) protein inhibits RNA silencing in the mosquito Aedes aegypti by interfering with Dicer. This VSR activity appears to be broadly conserved in the C proteins of other medically important flaviviruses, including that of ZIKV. These results suggest that a molecular "arms race" between vector and pathogen underlies the continued existence of flaviviruses in nature.
C1 [Samuel, Glady Hazitha; Adelman, Zach N.; Myles, Kevin M.] Texas A&M Univ, Dept Entomol, College Stn, TX 77843 USA.
[Wiley, Michael R.; Badawi, Atif] Virginia Polytech Inst & State Univ, Dept Entomol, Fralin Life Sci Inst, Blacksburg, VA 24061 USA.
[Wiley, Michael R.] US Army, Med Res Inst Infect Dis, Ctr Genome Sci, Ft Detrick, MD 21702 USA.
RP Myles, KM (reprint author), Texas A&M Univ, Dept Entomol, College Stn, TX 77843 USA.
EM mylesk@tamu.edu
FU National Institute for Allergy and Infectious Diseases [AI077726,
AI103265, AI119081]
FX This work was supported by National Institute for Allergy and Infectious
Diseases Grants AI077726, AI103265, and AI119081. The funding agency had
no role in study design, data collection and analysis, decision to
publish, or preparation of the manuscript.
NR 55
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U1 9
U2 9
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD NOV 29
PY 2016
VL 113
IS 48
BP 13863
EP 13868
DI 10.1073/pnas.1600544113
PG 6
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA ED4QR
UT WOS:000388835700086
PM 27849599
ER
PT J
AU Schnee, VP
Bright, CJ
Nallon, EC
Polcha, MP
AF Schnee, Vincent P.
Bright, Collin J.
Nallon, Eric C.
Polcha, Michael P.
TI Contact printing of a quantum dot and polymer cross-reactive array
sensor
SO SENSORS AND ACTUATORS B-CHEMICAL
LA English
DT Article
DE Quantum dot; Cross-Reactive array; Polymer composite; Contact printing;
Polymer stamping; PDMS
ID MOLECULARLY IMPRINTED POLYMER; LIGHT-EMITTING DEVICES; DISPLAYS;
SURFACE; LAYER
AB Contact printing of Quantum Dot (QD) and organic polymer (OP) composites is explored as an alternate method of fabricating a cross-reactive chemical sensor array. Sensing layers fabricated by inkjet printing and contact printing methods are compared, showing that contact printing methods demonstrate a more uniform distribution of the QDs and higher signal to noise ratios (SNRs) when exposed to chemical vapors. A cross-reactive array was then fabricated with CdSe QDs and five OPs and exposed to the vapor of 15 common laboratory solvents. Principal component analysis (PCA) of the data showed high dimensionality of the sensor array response and linear discriminant analysis (LDA) produced correct classification of the target analytes in 100% of test cases. Published by Elsevier B.V.
C1 [Schnee, Vincent P.; Nallon, Eric C.] US Army, RDECOM CERDEC Night Vis & Elect Sensors Directora, Ft Belvoir, VA 22060 USA.
[Bright, Collin J.] CACI Int Inc, Arlington, VA 22201 USA.
[Polcha, Michael P.] Fulcrum IT Serv, Centreville, VA 20120 USA.
RP Schnee, VP (reprint author), US Army, RDECOM CERDEC Night Vis & Elect Sensors Directora, Ft Belvoir, VA 22060 USA.
EM vincent.p.schnee.civ@mail.mil
NR 19
TC 0
Z9 0
U1 7
U2 7
PU ELSEVIER SCIENCE SA
PI LAUSANNE
PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND
SN 0925-4005
J9 SENSOR ACTUAT B-CHEM
JI Sens. Actuator B-Chem.
PD NOV 29
PY 2016
VL 236
BP 506
EP 511
DI 10.1016/j.snb.2016.06.036
PG 6
WC Chemistry, Analytical; Electrochemistry; Instruments & Instrumentation
SC Chemistry; Electrochemistry; Instruments & Instrumentation
GA DU5CM
UT WOS:000382229700061
ER
PT J
AU Recchia, F
Weisshaar, D
Gade, A
Tostevin, JA
Janssens, RVF
Albers, M
Bader, VM
Baugher, T
Bazin, D
Berryman, JS
Brown, BA
Campbell, CM
Carpenter, MP
Chen, J
Chiara, CJ
Crawford, HL
Hoffman, CR
Kondev, FG
Korichi, A
Langer, C
Lauritsen, T
Liddick, SN
Lunderberg, E
Noji, S
Prokop, C
Stroberg, SR
Suchyta, S
Wimmer, K
Zhu, S
AF Recchia, F.
Weisshaar, D.
Gade, A.
Tostevin, J. A.
Janssens, R. V. F.
Albers, M.
Bader, V. M.
Baugher, T.
Bazin, D.
Berryman, J. S.
Brown, B. A.
Campbell, C. M.
Carpenter, M. P.
Chen, J.
Chiara, C. J.
Crawford, H. L.
Hoffman, C. R.
Kondev, F. G.
Korichi, A.
Langer, C.
Lauritsen, T.
Liddick, S. N.
Lunderberg, E.
Noji, S.
Prokop, C.
Stroberg, S. R.
Suchyta, S.
Wimmer, K.
Zhu, S.
TI Neutron single-particle strengths at N=40, 42: Neutron knockout from
Ni-68,Ni-70 ground and isomeric states
SO PHYSICAL REVIEW C
LA English
DT Article
ID NUCLEI; ARRAY; BEAMS
AB The distribution of single-particle strength in Ni-67,Ni-69 was characterized with one-neutron knockout reactions from intermediate-energy Ni-68,Ni-70 secondary beams, selectively populating neutron-hole configurations at N = 39 and 41, respectively. The spectroscopic strengths deduced from the measured partial cross sections to the individual final states, as tagged by their gamma-ray decays, are used to identify and quantify neutron configurations in the wave functions. While Ni-69 compares well with shell-model predictions, the results for Ni-67 challenge the validity of current effective shell-model Hamiltonians by revealing discrepancies that cannot be explained so far. These results suggest that our understanding of the low-lying states in the neutron-rich, semimagic Ni isotopes may be incomplete and requires further investigation on both the experimental and theoretical sides.
C1 [Recchia, F.; Weisshaar, D.; Gade, A.; Bader, V. M.; Baugher, T.; Bazin, D.; Berryman, J. S.; Brown, B. A.; Chen, J.; Langer, C.; Liddick, S. N.; Lunderberg, E.; Noji, S.; Prokop, C.; Stroberg, S. R.; Suchyta, S.; Wimmer, K.] Michigan State Univ, Natl Superconducting Cyclotron Lab, E Lansing, MI 48824 USA.
[Recchia, F.] Univ Padua, Dipartimento Fis & Astron Galileo Galilei, I-35131 Padua, Italy.
[Recchia, F.] INFN Padova, I-35131 Padua, Italy.
[Gade, A.; Bader, V. M.; Baugher, T.; Brown, B. A.; Lunderberg, E.; Stroberg, S. R.] Michigan State Univ, Dept Phys & Astron, E Lansing, MI 48824 USA.
[Tostevin, J. A.] Univ Surrey, Dept Phys, Guildford GU2 7XH, Surrey, England.
[Janssens, R. V. F.; Albers, M.; Carpenter, M. P.; Chiara, C. J.; Hoffman, C. R.; Korichi, A.; Lauritsen, T.; Zhu, S.] Argonne Natl Lab, Div Phys, Argonne, IL 60439 USA.
[Campbell, C. M.; Crawford, H. L.] Lawrence Berkeley Natl Lab, Div Nucl Sci, Berkeley, CA 94720 USA.
[Chen, J.; Kondev, F. G.] Argonne Natl Lab, Nucl Engn Div, 9700 S Cass Ave, Argonne, IL 60439 USA.
[Korichi, A.] CNRS, CSNSM, IN2P3, Orsay Campus, F-91405 Orsay, France.
[Liddick, S. N.; Prokop, C.; Suchyta, S.] Michigan State Univ, Dept Phys, E Lansing, MI 48824 USA.
[Wimmer, K.] Cent Michigan Univ, Dept Phys, Mt Pleasant, MI 48859 USA.
[Baugher, T.] Los Alamos Natl Lab, Los Alamos, NM 87545 USA.
[Chiara, C. J.] US Army Res Lab, Adelphi, MD 20783 USA.
[Stroberg, S. R.] TRIUMF, Vancouver, BC V6T 2A3, Canada.
[Suchyta, S.] Univ Calif Berkeley, Dept Nucl Engn, Berkeley, CA 94720 USA.
[Wimmer, K.] Univ Tokyo, Dept Phys, Bunkyo Ku, Tokyo 1130033, Japan.
RP Recchia, F (reprint author), Michigan State Univ, Natl Superconducting Cyclotron Lab, E Lansing, MI 48824 USA.; Recchia, F (reprint author), Univ Padua, Dipartimento Fis & Astron Galileo Galilei, I-35131 Padua, Italy.; Recchia, F (reprint author), INFN Padova, I-35131 Padua, Italy.
EM francesco.recchia@unipd.it
RI Gade, Alexandra/A-6850-2008;
OI Gade, Alexandra/0000-0001-8825-0976; Recchia,
Francesco/0000-0002-8428-0112
FU National Science Foundation (NSF) [PHY-1102511]; U.S. Department of
Energy (DOE), Office of Nuclear Physics [DE-FG02-08ER41556,
DE-FG02-94-ER40834, DE-AC02-06CH11357]; DOE, National Nuclear Security
Administration [DE-NA0000979]; DOE, Office of Science; NSF [PHY-1102511,
PHY-1404442]; DOE [DE-AC02-05CH11231]; United Kingdom Science and
Technology Facilities Council (STFC) [ST/L005743/1]; GRETINA campaign at
NSCL
FX We thank the staff of the Coupled Cyclotron Facility for the delivery of
high-quality beams. We are grateful for Augusto Macchiavelli's support
of the GRETINA campaign at NSCL. This work was supported in part by the
the National Science Foundation (NSF) under Contract No. PHY-1102511, by
the U.S. Department of Energy (DOE), Office of Nuclear Physics, under
Grants No. DE-FG02-08ER41556 (Michigan State University) and No.
DE-FG02-94-ER40834 (University of Maryland), and Contract No.
DE-AC02-06CH11357 (Argonne National Laboratory), and by the DOE,
National Nuclear Security Administration, under Award No. DE-NA0000979.
GRETINA was funded by the DOE, Office of Science. Operation of the array
at NSCL was supported by the NSF under Cooperative Agreement No.
PHY-1102511 (NSCL) and DOE under Grant No. DE-AC02-05CH11231 (LBNL).
B.A.B. acknowledges support from NSF Grant No. PHY-1404442 and J.A.T.
from the United Kingdom Science and Technology Facilities Council (STFC)
Grant No. ST/L005743/1.
NR 48
TC 1
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U1 5
U2 5
PU AMER PHYSICAL SOC
PI COLLEGE PK
PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA
SN 2469-9985
EI 2469-9993
J9 PHYS REV C
JI Phys. Rev. C
PD NOV 28
PY 2016
VL 94
IS 5
AR 054324
DI 10.1103/PhysRevC.94.054324
PG 9
WC Physics, Nuclear
SC Physics
GA ED4MD
UT WOS:000388821800006
ER
PT J
AU Drechsler, R
Chen, SW
Dancy, BCR
Mehrabkhani, L
Olsen, CP
AF Drechsler, Robin
Chen, Shaw-Wen
Dancy, Blair C. R.
Mehrabkhani, Lena
Olsen, Carissa Perez
TI HPLC-Based Mass Spectrometry Characterizes the Phospholipid Alterations
in Ether-Linked Lipid Deficiency Models Following Oxidative Stress
SO PLOS ONE
LA English
DT Article
ID CAENORHABDITIS-ELEGANS; LC-MS; PLASMALOGENS; HOMEOSTASIS; REVEALS
AB Despite the fact that the discovery of ether-linked phospholipids occurred nearly a century ago, many unanswered questions remain concerning these unique lipids. Here, we characterize the ether-linked lipids of the nematode with HPLC-MS/MS and find that more than half of the phosphoethanolamine-containing lipids are ether-linked, a distribution similar to that found in mammalian membranes. To explore the biological role of ether lipids in vivo, we target fatty acyl-CoA reductase (fard-1), an essential enzyme in ether lipid synthesis, with two distinct RNAi strategies. First, when fard-1 RNAi is initiated at the start of development, the treated animals have severely reduced ether lipid abundance, resulting in a shift in the phosphatidylethanolamine lipid population to include more saturated fatty acid chains. Thus, the absence of ether lipids during development drives a significant remodeling of the membrane landscape. A later initiation of fard-1 RNAi in adulthood results in a dramatic reduction of new ether lipid synthesis as quantified with N-15-tracers; however, there is only a slight decrease in total ether lipid abundance with this adult-only fard-1 RNAi. The two RNAi strategies permit the examination of synthesis and ether lipid abundance to reveal a relationship between the amount of ether lipids and stress survival. We tested whether these species function as sacrificial antioxidants by directly examining the phospholipid population with HPLC-MS/MS after oxidative stress treatment. While there are significant changes in other phospholipids, including polyunsaturated fatty acid-containing species, we did not find any change in ether-linked lipids, suggesting that the role of ether lipids in stress resistance is not through their general consumption as free radical sinks. Our work shows that the nematode will be a useful model for future interrogation of ether lipid biosynthesis and the characterization of phospholipid changes in various stress conditions.
C1 [Drechsler, Robin; Chen, Shaw-Wen; Dancy, Blair C. R.; Mehrabkhani, Lena; Olsen, Carissa Perez] Fred Hutchinson Canc Res Ctr, Div Basic Sci, 1124 Columbia St, Seattle, WA 98104 USA.
[Dancy, Blair C. R.] US Army, Ctr Environm Hlth Res, Ft Detrick, MD USA.
RP Olsen, CP (reprint author), Fred Hutchinson Canc Res Ctr, Div Basic Sci, 1124 Columbia St, Seattle, WA 98104 USA.
EM cpolsen@fredhutch.org
OI Olsen, Carissa/0000-0003-1261-9364
FU NIH Early Independence Award from the Office of the Director [5 DP5
OD009189]; National Institute of Dental and Craniofacial Research;
University of Washington's Nathan Shock Center for Excellence in Aging
[P30AG013280]
FX This work was supported in part by an NIH Early Independence Award (5
DP5 OD009189) from the Office of the Director and the National Institute
of Dental and Craniofacial Research (www.nih.gov) and funding
(P30AG013280) from the University of Washington's Nathan Shock Center
for Excellence in Aging (uwaging.org/shock-center). The funders had no
role in study design, data collection and analysis, decision to publish,
or preparation of the manuscript.
NR 27
TC 0
Z9 0
U1 3
U2 3
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD NOV 28
PY 2016
VL 11
IS 11
AR e0167229
DI 10.1371/journal.pone.0167229
PG 22
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA EE3FE
UT WOS:000389472400105
PM 27893806
ER
PT J
AU Cadieux, CL
Wang, HY
Zhang, YC
Koenig, JA
Shih, TM
McDonough, J
Koh, J
Cerasoli, D
AF Cadieux, C. Linn
Wang, Haoyu
Zhang, Yuchen
Koenig, Jeffrey A.
Shih, Tsung-Ming
McDonough, John
Koh, John
Cerasoli, Douglas
TI Probing the activity of a non-oxime reactivator for acetylcholinesterase
inhibited by organophosphorus nerve agents
SO CHEMICO-BIOLOGICAL INTERACTIONS
LA English
DT Article; Proceedings Paper
CT 12th International Meeting on Cholinesterases / 6th International
Conference on Paraoxonase
CY 2015
CL Elche, SPAIN
DE Reactivator; Oxime; Organophosphorus nerve agent; Pralidoxime; Guinea
pig; Acetylcholinesterase
ID PIG ACETYLCHOLINESTERASE; KINETIC APPROACH; EFFICACY; BRAIN
AB Currently fielded treatments for nerve agent intoxication include atropine, an acetylcholine receptor antagonist, and pralidoxime (2PAM), a small molecule reactivator of acetylcholinesterase (AChE). 2PAM reactivates nerve agent-inhibited AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Due to a permanently charged pyridinium motif, 2PAM is not thought to cross the blood brain barrier and therefore cannot act directly in the neuronal junctions of the brain. In this study, ADOC, a non-permanently charged, non-oxime molecule initially identified using pesticide-inhibited AChE, was characterized in vitro against nerve agent-inhibited recombinant human AChE. The inhibitory and reactivation potentials of ADOC were determined with native AChE and AChE inhibited with tabun, sarin, soman, cyclosarin, VX, or VR and then compared to those of 2PAM. Several structural analogs of ADOC were used to probe the reactivation mechanism of the molecule. Finally, guinea pigs were used to examine the protective efficacy of the compound after exposure to sarin. The results of both in vitro and in vivo testing will be useful in the design of future small molecule reactivators. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
C1 [Cadieux, C. Linn; Koenig, Jeffrey A.; Shih, Tsung-Ming; McDonough, John; Cerasoli, Douglas] US Army, Med Res Inst Chem Def, Div Res, Aberdeen Proving Ground, MD 21010 USA.
[Wang, Haoyu; Zhang, Yuchen; Koh, John] Univ Delaware, Dept Chem & Biochem, Newark, DE 19716 USA.
RP Cadieux, CL (reprint author), US Army, Med Res Inst Chem Def, Div Res, Aberdeen Proving Ground, MD 21010 USA.
EM christena.l.cadieux.ctr@mail.mil
NR 24
TC 0
Z9 0
U1 6
U2 6
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 0009-2797
EI 1872-7786
J9 CHEM-BIOL INTERACT
JI Chem.-Biol. Interact.
PD NOV 25
PY 2016
VL 259
SI SI
BP 133
EP 141
DI 10.1016/j.cbi.2016.04.002
PN B
PG 9
WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
GA ED4TC
UT WOS:000388843500013
PM 27062893
ER
PT J
AU Kirkpatrick, MG
diTargiani, RC
Sweeney, RE
Otto, TC
AF Kirkpatrick, Melanie G.
diTargiani, Robert C.
Sweeney, Richard E.
Otto, Tamara C.
TI Use of V agents and V-analogue compounds to probe the active site of
atypical butyrylcholinesterase from Oryzias latipes
SO CHEMICO-BIOLOGICAL INTERACTIONS
LA English
DT Article; Proceedings Paper
CT 12th International Meeting on Cholinesterases / 6th International
Conference on Paraoxonase
CY 2015
CL Elche, SPAIN
DE Cholinesterase; Nerve agent; Organophosphorus; Spontaneous reactivation
ID NERVE AGENT; ORGANOPHOSPHORUS COMPOUNDS; SPONTANEOUS REACTIVATION;
GUINEA-PIGS; ACETYLCHOLINESTERASE; ENZYME; PSEUDOCHOLINESTERASE;
DETOXIFICATION; INHIBITION; PROTECTION
AB The atypical butyrylcholinesterase (aBuChE) from Oryzias latipes shares approximately 65% sequence similarity to both acetylcholinesterase and butyrylcholinesterase and was studied for its capacity to spontaneously reactivate following inhibition by organophosphorus nerve agents. Like other cholinesterases, aBuChE was inhibited by all G-and V-type nerve agents. Interestingly, aBuChE was able to undergo spontaneous reactivation after inhibition with VR (t(1/2) = 5.5 +/- 0.2 h). Mass spectrometry of aBuChE after VR inhibition confirmed the presence of a covalently bound adduct of the size expected for non-aged VR on the peptide containing the active site serine. To understand the effect of substrate volume on rates of reactivation, the capacity of aBuChE to bind and spontaneously reactivate after inhibition with five V-agent analogues was examined. No appreciable reactivation was detected for enzyme inhibited by V2 (VX with O-isopropyl on retained group), V4 (VX with N-diethyl leaving group termination), or V5 (VX with N-dimethyl leaving group termination). Minimal reactivation was detected with V1 (VX with O-propyl on retained group). Conversely, spontaneous reactivation was observed when aBuChE was inhibited by V3 (VX with O-isobutyl on retained group; t(1/2) = 6.3 +/- 0.4 h). The data suggest that the ability of aBuChE to spontaneously reactivate after inhibition by V-agent analogues is related to the structure of the retained group. These results provide structural information that may shed light on the design of improved small molecule reactivators of nerve agent-inhibited acetylcholinesterase or butyrylcholinesterase, and further suggest that re-engineering the active site of a cholinesterase could result in enzymes with clinically relevant rates of nerve agent hydrolysis. Published by Elsevier Ireland Ltd.
C1 [Kirkpatrick, Melanie G.; Otto, Tamara C.] US Army, Med Res Inst Chem Def, Physiol & Immunol Branch Res Div, 2900 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA.
[diTargiani, Robert C.] US Army, Med Res Inst Chem Def, Med Diagnost & Chem Branch, 2900 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA.
[Sweeney, Richard E.] US Army, Med Res Inst Chem Def, Pharmacol Branch Res Div, 2900 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA.
RP Otto, TC (reprint author), US Army, Med Res Inst Chem Def, 2900 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA.
EM tamara.c.otto.civ@mail.mil
NR 21
TC 0
Z9 0
U1 1
U2 1
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 0009-2797
EI 1872-7786
J9 CHEM-BIOL INTERACT
JI Chem.-Biol. Interact.
PD NOV 25
PY 2016
VL 259
SI SI
BP 182
EP 186
DI 10.1016/j.cbi.2016.03.016
PN B
PG 5
WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
GA ED4TC
UT WOS:000388843500020
PM 27000540
ER
PT J
AU McCranor, BJ
Hofstetter, CA
Olert, MA
Moorad-Doctor, D
Cerasoli, DM
Garcia, GE
AF McCranor, Bryan J.
Hofstetter, Catherine A.
Olert, Melissa A.
Moorad-Doctor, Deborah
Cerasoli, Douglas M.
Garcia, Gregory E.
TI Targeting of organophosphorus compound bioscavengers to the surface of
red blood cells
SO CHEMICO-BIOLOGICAL INTERACTIONS
LA English
DT Article; Proceedings Paper
CT 12th International Meeting on Cholinesterases / 6th International
Conference on Paraoxonase
CY 2015
CL Elche, SPAIN
DE Bioscavenger; Organophosphorus; Paraoxonase-1; Red blood cells; Single
chain variable fragment; Glycophorin A
ID GLYCOPHORIN-A; NERVE AGENTS; BUTYRYLCHOLINESTERASE; INTOXICATION;
PREVENTION; HYDROLASES
AB To develop a prophylactic for organophosphorus (OP) poisoning utilizing catalytic bioscavengers, the circulatory stability of the enzymes needs to be increased. One strategy for increasing the bioavailability of OP bioscavengers is to target them to the surface of red blood cells (RBCs). Given the circulatory lifespan of 120 days for human RBCs, this strategy has the potential for creating a persistent pool of bioscavenger. Here we report the development of fusion proteins with a single chain variable fragment (scFv) of Ter119, a molecule that associates with glycophorin A on the surface of RBCs, and the VIID11 variant of paraoxonase 1 (scFv-PON1). We show that scFv-PON1 variants expressed by Trichoplusia ni larvae are catalytically active and that one variant in particular can successfully bind to the surface of murine RBCs both in vitro and in vivo. This study represents a proof of concept for targeting catalytic bioscavengers to the surface of RBCs and is an early step in developing catalytic bioscavengers that can remain in circulation for an extended period of time. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
C1 [McCranor, Bryan J.; Hofstetter, Catherine A.; Olert, Melissa A.; Moorad-Doctor, Deborah; Cerasoli, Douglas M.; Garcia, Gregory E.] US Army, Med Res Inst Chem Def, 2900 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA.
RP McCranor, BJ (reprint author), US Army, Med Res Inst Chem Def, 2900 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA.
EM bryan.j.mccranor.ctr@mail.mil
NR 28
TC 0
Z9 0
U1 2
U2 2
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 0009-2797
EI 1872-7786
J9 CHEM-BIOL INTERACT
JI Chem.-Biol. Interact.
PD NOV 25
PY 2016
VL 259
SI SI
BP 205
EP 210
DI 10.1016/j.cbi.2016.05.007
PN B
PG 6
WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
GA ED4TC
UT WOS:000388843500022
PM 27163849
ER
PT J
AU Mata, DG
Sabnekar, P
Watson, CA
Rezk, PE
Chilukuri, N
AF Mata, David G.
Sabnekar, Praveena
Watson, Cetara A.
Rezk, Peter E.
Chilukuri, Nageswararao
TI Assessing the stoichiometric efficacy of mammalian expressed
paraoxonase-1 variant I-F11 to afford protection against G-type nerve
agents
SO CHEMICO-BIOLOGICAL INTERACTIONS
LA English
DT Article; Proceedings Paper
CT 12th International Meeting on Cholinesterases / 6th International
Conference on Paraoxonase
CY 2015
CL Elche, SPAIN
DE Catalytic bioscavengers; Chemical warfare nerve agents; Engineered
paraoxonase-1 variants; High density lipoprotein-association;
Adenovirus-mediated gene delivery system
ID DENSITY-LIPOPROTEIN OXIDATION; IN-VIVO; HUMAN BUTYRYLCHOLINESTERASE;
DIRECTED EVOLUTION; CHOLESTEROL EFFLUX; GENE-TRANSFER; PON1;
INTOXICATION; PREVENTION; HYDROLASES
AB We evaluated the ability of evolved paraoxonase-1 (PON1) to afford broad spectrum protection against G-type nerve agents when produced in mammalian cells via an adenovirus expression system. The PON1 variants G3C9, VII-D11, I-F11, VII-D2 and II-G1 were screened in vitro for their ability to hydrolyze Gagents, as well as for their preference towards hydrolysis of the more toxic P(-) isomer. I-F11, with catalytic efficiencies of (1.1 +/- 0.1) x 10(6) M-1 min-1, (2.5 +/- 0.1) x 10(6) M-1 min(-1), (2.3 +/- 0.5)-10(7) M-1 min(-1) and (9.2 +/- 0.1) x 10(6) M-1 min(-1) against tabun (GA), sarin (GB), soman (GD) and cyclosarin (GF), respectively, was found to be a leading candidate for further evaluation. To demonstrate the broad spectrum efficacy of I-F11 against G-agents, a sequential 5 x LD50 dose of GD, GF, GB and GA was administered to ten mice expressing I-F11 on days 3, 4, 5 and 6 following virus injection, respectively. At the conclusion of the experiment, 80% of the animals survived exposure to all four G-agents. Using the concept of stoichiometric efficacy, we determined that I-F11 affords protection from lethality against an administered dose of 10, 15, 90 and 80 molar equivalents of GA, GB, GD and GF, respectively, relative to the molar equivalents of I-F11 in circulation. It also appears that I-F11 can associate with high density lipoprotein in circulation, suggesting that I-F11 retained this function of native PON1. This combination of attractive attributes demonstrates that I-F11 is an attractive candidate for development as a broad-therapeutic against G-type nerve agent exposure. Published by Elsevier Ireland Ltd.
C1 [Mata, David G.; Sabnekar, Praveena; Watson, Cetara A.; Rezk, Peter E.; Chilukuri, Nageswararao] US Army, Med Res Inst Chem Def, Div Res, Physiol & Immunol Branch, 2900 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA.
RP Chilukuri, N (reprint author), US Army, Med Res Inst Chem Def, Div Res, Physiol & Immunol Branch, 2900 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA.
EM Nageswararao.chilukuri.civ@mail.mil
NR 29
TC 0
Z9 0
U1 1
U2 1
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 0009-2797
EI 1872-7786
J9 CHEM-BIOL INTERACT
JI Chem.-Biol. Interact.
PD NOV 25
PY 2016
VL 259
SI SI
BP 233
EP 241
DI 10.1016/j.cbi.2016.04.013
PN B
PG 9
WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
GA ED4TC
UT WOS:000388843500025
PM 27083144
ER
PT J
AU Jahnke, JP
Benyamin, MS
Sumner, JJ
Mackie, DM
AF Jahnke, Justin P.
Benyamin, Marcus S.
Sumner, James J.
Mackie, David M.
TI Using Reverse Osmosis Membranes to Couple Direct Ethanol Fuel Cells with
Ongoing Fermentations
SO INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
LA English
DT Article
ID SACCHAROMYCES-CEREVISIAE; ACETIC-ACID; FOOD WASTE; PRODUCTS;
PERVAPORATION; BIOMASS; PERFORMANCE; SEPARATION; RECOVERY
AB Separations in biological systems remain a challenging problem and can be particularly so in the case of biofuels, where purification; can use a significant fraction of the energy content of the fuel. For small-molecule biofuels like ethanol, reverse osmosis (RO) membranes show promise as passive purifiers, in that they allow uncharged small molecules to pass through while blocking most other components of the growth medium. Here, we examine the use of RO membranes in developing biohybrid fuel cells, closely examining the case where a direct ethanol fuel cell (DEFC) is coupled with an ongoing yeast fermentation across an RO membrane. We show that, contrary to initial good performance, the acetic acid produced by the DEFC readily diffuses back across the RO membrane and kills the fermentation after a few days. We introduce an amelioration chamber where the acetic acid is converted to acetate ions. The RO membrane rejects the acetate ions due to their charge, preventing acetic acid buildup in the fermentation. We also show that some small, charged components of the fermentation such as amino acids are imperfectly rejected by RO membranes. Because of the high sensitivity of DEFCs to low concentrations (10s of mu M) of amino acids, even a very slow diffusion of amino acids across the RO membranes can limit biohybrid fuel cell lifetimes.
C1 [Jahnke, Justin P.; Benyamin, Marcus S.; Sumner, James J.; Mackie, David M.] US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20740 USA.
RP Jahnke, JP (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20740 USA.
EM justin.jahnke2.ctr@mail.mil
FU U.S. Army Research Laboratory Postdoctoral Fellowship Program; College
Qualified Leaders (CQL) program of the U.S. Army Educational Outreach
Program (AEOP)
FX This contribution was identified by Prof. Taejin Kim (SUNY Stony Brook)
as the Best Presentation in the session "ENFL: Fuel Cells" of the 2016
ACS Spring National Meeting in San Diego, CA. J.P.J. was supported from
the U.S. Army Research Laboratory Postdoctoral Fellowship Program
administered by the Oak Ridge Associated Universities. M.S.B. was
supported from the College Qualified Leaders (CQL) program of the U.S.
Army Educational Outreach Program (AEOP).
NR 33
TC 1
Z9 1
U1 4
U2 4
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0888-5885
J9 IND ENG CHEM RES
JI Ind. Eng. Chem. Res.
PD NOV 23
PY 2016
VL 55
IS 46
BP 12091
EP 12098
DI 10.1021/acs.iecr.6b02915
PG 8
WC Engineering, Chemical
SC Engineering
GA ED5SM
UT WOS:000388912600025
ER
PT J
AU Vatamanu, J
Vatamanu, M
Borodin, O
Bedrov, D
AF Vatamanu, Jenel
Vatamanu, Mihaela
Borodin, Oleg
Bedrov, Dmitry
TI A comparative study of room temperature ionic liquids and their organic
solvent mixtures near charged electrodes
SO JOURNAL OF PHYSICS-CONDENSED MATTER
LA English
DT Article
DE supercapacitors; ionic liquids; electric double layer; organic solvents
ID MOLECULAR-DYNAMICS SIMULATION; ELECTRICAL DOUBLE-LAYER; SUM-FREQUENCY
GENERATION; DIFFERENTIAL CAPACITANCE; QUANTUM CAPACITANCE; CARBON
ELECTRODES; ENERGY-STORAGE; ELECTROCHEMICAL CAPACITORS; 2-DIMENSIONAL
PERIODICITY; SUPERCAPACITOR ELECTRODES
AB The structural properties of electrolytes consisting of solutions of ionic liquids in a polar solvent at charged electrode surfaces are investigated using classical atomistic simulations. The studied electrolytes consisted of tetraethylammonium tetrafluoroborate (NEt4-BF4), 1-ethyl-3-methylimidazolium tetrafluoroborate (c(2)mim-BF4) and 1-octyl-3-methylimidazolium tetrafluoroborate (c(8)mim-BF4) salts dissolved in acetonitrile solvent. We discuss the influence of electrolyte concentration, chemical structure of the ionic salt, temperature, conducting versus semiconducting nature of the electrode, electrode geometry and surface roughness on the electric double layer structure and capacitance and compare these properties with those obtained for pure room temperature ionic liquids. We show that electrolytes consisting of solutions of ions can behave quite differently from pure ionic liquid electrolytes.
C1 [Vatamanu, Jenel; Vatamanu, Mihaela; Bedrov, Dmitry] Univ Utah, MSE Dept, Salt Lake City, UT 84112 USA.
[Borodin, Oleg] Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
RP Vatamanu, J (reprint author), Univ Utah, MSE Dept, Salt Lake City, UT 84112 USA.
EM u0615401@utah.edu; d.bedrov@utah.edu
FU University of Utah MRSEC (National Science Foundation) [DMR 11-21252];
Army Research Laboratory [W911NF-12-2-0023]
FX This work was supported by the University of Utah MRSEC (National
Science Foundation Grant #DMR 11-21252) and by the Army Research
Laboratory under Cooperative Agreement number W911NF-12-2-0023. The
views and conclusions contained in this document are those of the
authors and should not be interpreted as representing the official
policies, either expressed or implied, of the Army Research Laboratory
or the US Government.
NR 139
TC 0
Z9 0
U1 67
U2 67
PU IOP PUBLISHING LTD
PI BRISTOL
PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
SN 0953-8984
EI 1361-648X
J9 J PHYS-CONDENS MAT
JI J. Phys.-Condes. Matter
PD NOV 23
PY 2016
VL 28
IS 46
SI SI
AR 464002
DI 10.1088/0953-8984/28/46/464002
PG 18
WC Physics, Condensed Matter
SC Physics
GA DY9HC
UT WOS:000385443500002
PM 27623976
ER
PT J
AU Martini, WZ
AF Martini, Wenjun Z.
TI Coagulation complications following trauma
SO MILITARY MEDICAL RESEARCH
LA English
DT Review
DE Traumatic injury; Coagulation; Sepsis; Lethal triad; Pathophysiology
ID FRESH-FROZEN PLASMA; RED-BLOOD-CELLS; DAMAGE CONTROL RESUSCITATION;
CARDIAC-SURGERY PATIENTS; HYDROXYETHYL STARCH; ACUTE COAGULOPATHY;
PROPHYLACTIC FIBRINOGEN; HEMORRHAGIC-SHOCK; PLATELET-FUNCTION;
PROTHROMBIN TIME
AB Traumatic injury is one of the leading causes of death, with uncontrolled hemorrhage from coagulation dysfunction as one of the main potentially preventable causes of the mortality. Hypothermia, acidosis, and resuscitative hemodilution have been considered as the significant contributors to coagulation manifestations following trauma, known as the lethal triad. Over the past decade, clinical observations showed that coagulopathy may be present as early as hospital admission in some severely injured trauma patients. The hemostatic dysfunction is associated with higher blood transfusion requirements, longer hospital stay, and higher mortality. The recognition of this early coagulopathy has initiated tremendous interest and effort in the trauma community to expand our understanding of the underlying pathophysiology and improve clinical treatments. This review discusses the current knowledge of coagulation complications following trauma.
C1 [Martini, Wenjun Z.] US Army Inst Surg Res, 3698 Chambers Pass, Houston, TX 78234 USA.
RP Martini, WZ (reprint author), US Army Inst Surg Res, 3698 Chambers Pass, Houston, TX 78234 USA.
EM wenjun.z.martini.civ@mail.mil
NR 88
TC 0
Z9 0
U1 0
U2 0
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 2054-9369
J9 MILITARY MED RES
JI MILITARY MED. RES.
PD NOV 22
PY 2016
VL 3
AR UNSP 35
DI 10.1186/s40779-016-0105-2
PG 7
WC Medicine, General & Internal
SC General & Internal Medicine
GA EM4IP
UT WOS:000395277000001
PM 27895932
ER
PT J
AU Kusi, KA
Bosomprah, S
Kyei-Baafour, E
Dickson, EK
Tornyigah, B
Angov, E
Dutta, S
Dodoo, D
Sedegah, M
Koram, KA
AF Kusi, Kwadwo A.
Bosomprah, Samuel
Kyei-Baafour, Eric
Dickson, Emmanuel K.
Tornyigah, Bernard
Angov, Evelina
Dutta, Sheetij
Dodoo, Daniel
Sedegah, Martha
Koram, Kwadwo A.
TI Seroprevalence of Antibodies against Plasmodium falciparum Sporozoite
Antigens as Predictive Disease Transmission Markers in an Area of Ghana
with Seasonal Malaria Transmission
SO PLOS ONE
LA English
DT Article
ID KASSENA-NANKANA DISTRICT; NORTHERN GHANA; SURFACE-ANTIGENS; AGE
PATTERNS; INTENSITY; EXPOSURE; UGANDA; MODEL; MEROZOITE; CHILDREN
AB Introduction
As an increasing number of malaria-endemic countries approach the disease elimination phase, sustenance of control efforts and effective monitoring are necessary to ensure success. Mathematical models that estimate anti-parasite antibody seroconversion rates are gaining relevance as more sensitive transmission intensity estimation tools. Models however estimate yearly seroconversion and seroreversion rates and usually predict long term changes in transmission, occurring years before the time of sampling. Another challenge is the identification of appropriate antigen targets since specific antibody levels must directly reflect changes in transmission patterns. We therefore investigated the potential of antibodies to sporozoite and blood stage antigens for detecting short term differences in malaria transmission in two communities in Northern Ghana with marked, seasonal transmission.
Methods
Cross-sectional surveys were conducted during the rainy and dry seasons in two communities, one in close proximity to an irrigation dam and the other at least 20 Km away from the dam. Antibodies against the sporozoite-specific antigens circumsporozoite protein (CSP) and Cell traversal for ookinetes and sporozoites (CelTOS) and the classical blood stage antigen apical membrane antigen 1 (AMA1) were measured by indirect ELISA. Antibody levels and seroprevalence were compared between surveys and between study communities. Antibody seroprevalence data were fitted to a modified reversible catalytic model to estimate the seroconversion and seroreversion rates.
Results
Changes in sporozoite-specific antibody levels and seroprevalence directly reflected differences in parasite prevalence between the rainy and dry seasons and hence the extent of malaria transmission. Seroconversion rate estimates from modelled seroprevalence data did not however support the above observation.
Conclusions
The data confirms the potential utility of sporozoite-specific antigens as useful markers for monitoring short term/seasonal changes in malaria transmission. It may however be essential to update models to allow for assessment of seasonal changes in malaria transmission, which usually occur within four to six months.
C1 [Kusi, Kwadwo A.; Kyei-Baafour, Eric; Dickson, Emmanuel K.; Tornyigah, Bernard; Dodoo, Daniel] Univ Ghana, Noguchi Mem Inst Med Res, Dept Immunol, Coll Hlth Sci, Legon, Accra, Ghana.
[Bosomprah, Samuel] Univ Ghana, Sch Publ Hlth, Dept Biostat, Coll Hlth Sci, Legon, Accra, Ghana.
[Angov, Evelina; Dutta, Sheetij] Walter Reed Army Inst Res, Malaria Vaccine Branch, Silver Spring, MD USA.
[Sedegah, Martha] Naval Med Res Ctr, Malaria Dept, Silver Spring, MD USA.
[Koram, Kwadwo A.] Univ Ghana, Coll Hlth Sci, Noguchi Mem Inst Med Res, Dept Epidemiol, Legon, Accra, Ghana.
RP Kusi, KA (reprint author), Univ Ghana, Noguchi Mem Inst Med Res, Dept Immunol, Coll Hlth Sci, Legon, Accra, Ghana.
EM akusi@noguchi.ug.edu.gh
OI Kusi, Kwadwo/0000-0001-5483-9985
FU Bill and Melinda Gates Foundation [OPP52155]
FX This work was supported by the Bill and Melinda Gates Foundation under
the Postdoctoral and Postgraduate Training in Infectious Diseases
Research awarded to the Noguchi Memorial Institute for Medical Research
(Global Health grant number OPP52155). The funders had no role in study
design, data collection and analysis, decision to publish, or
preparation of the manuscript.
NR 38
TC 0
Z9 0
U1 2
U2 2
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD NOV 22
PY 2016
VL 11
IS 11
AR e0167175
DI 10.1371/journal.pone.0167175
PG 16
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA ED5IV
UT WOS:000388886000054
PM 27875594
ER
PT J
AU Kobeissy, FH
Guingab-Cagmat, JD
Zhang, ZQ
Moghieb, A
Glushakova, OY
Mondello, S
Boutte, AM
Anagli, J
Rubenstein, R
Bahmad, H
Wagner, AK
Hayes, RL
Wang, KKW
AF Kobeissy, Firas H.
Guingab-Cagmat, Joy D.
Zhang, Zhiqun
Moghieb, Ahmed
Glushakova, Olena Y.
Mondello, Stefania
Boutte, Angela M.
Anagli, John
Rubenstein, Richard
Bahmad, Hisham
Wagner, Amy K.
Hayes, Ronald L.
Wang, Kevin K. W.
TI Neurprotemics and Systems Biology Approach to Identify Temporal
Biomarker Changes Post Experimental Traumatic Brain Injury in Rats
SO FRONTIERS IN NEUROLOGY
LA English
DT Article
DE proteomics; traumatic brain injury; controlled cortical impact;
biomarker; prognosis and therapeutics; inflammation; oxidative stress
ID NEURON-SPECIFIC ENOLASE; PROLYL ISOMERASE PIN1; SPINAL-CORD-INJURY;
LECITHINIZED SUPEROXIDE-DISMUTASE; TANDEM MASS-SPECTROMETRY; C-TERMINAL
HYDROLASE-L1; PROTEOMIC ANALYSIS; ALZHEIMERS-DISEASE; PROGNOSTIC
BIOMARKER; CEREBRAL-ISCHEMIA
AB Traumatic brain injury (TBI) represents a critical health problem of which diagnosis, management, and treatment remain challenging. TBI is a contributing factor in approximately one-third of all injury-related deaths in the United States. The Centers for Disease Control and Prevention estimate that 1.7 million people suffer a TBI in the United States annually. Efforts continue to focus on elucidating the complex molecular mechanisms underlying TBI pathophysiology and defining sensitive and specific biomarkers that can aid in improving patient management and care. Recently, the area of neuroproteomics-systems biology is proving to be a prominent tool in biomarker discovery for central nervous system injury and other neurological diseases. In this work, we employed the controlled cortical impact (CCI) model of experimental TBI in rat model to assess the temporal-global proteome changes after acute (1 day) and for the first time, subacute (7 days), post-injury time frame using the established cation-anion exchange chromatography-1D SDS gel electrophoresis LC-MS/MS platform for protein separation combined with discrete systems biology analyses to identify temporal biomarker changes related to this rat TBI model. Rather than focusing on any one individual molecular entity, we used in silico systems biology approach to understand the global dynamics that govern proteins that are differentially altered post-injury. In addition, gene ontology analysis of the proteomic data was conducted in order to categorize the proteins by molecular function, biological process, and cellular localization. Results show alterations in several proteins related to inflammatory responses and oxidative stress in both acute (1 day) and subacute (7 days) periods post-TBI. Moreover, results suggest a differential upregulation of neuroprotective proteins at 7 days post-CCI involved in cellular functions such as neurite growth, regeneration, and axonal guidance. Our study is among the first to assess temporal neuroproteome changes in the CCI model. Data presented here unveil potential neural biomarkers and therapeutic targets that could be used for diagnosis, for treatment and, most importantly, for temporal prognostic assessment following brain injury. Of interest, this work relies on in silico bioinformatics approach to draw its conclusion; further work is conducted for functional studies to validate and confirm the omics data obtained.
C1 [Kobeissy, Firas H.; Zhang, Zhiqun; Moghieb, Ahmed; Hayes, Ronald L.; Wang, Kevin K. W.] Univ Florida, McKnight Brain Inst, Dept Psychiat, Program Neurotrauma Neuroprote & Biomarkers Res, Gainesville, FL USA.
[Kobeissy, Firas H.; Zhang, Zhiqun; Moghieb, Ahmed; Hayes, Ronald L.; Wang, Kevin K. W.] Univ Florida, McKnight Brain Inst, Dept Neurosci, Program Neurotrauma Neuroprote & Biomarkers Res, Gainesville, FL USA.
[Guingab-Cagmat, Joy D.] Banyan Biomarkers Inc, Ctr Innovat Res, Alachua, FL USA.
[Glushakova, Olena Y.; Hayes, Ronald L.] Virginia Commonwealth Univ, Sch Med, Dept Neurosurg, Richmond, VA USA.
[Mondello, Stefania] Univ Messina, Dept Neurosci, Messina, Italy.
[Boutte, Angela M.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Brain Trauma Neuroprotect & Neurorestorat Branch, Silver Spring, MD USA.
[Anagli, John] NeuroTheranost Inc, Detroit, MI USA.
[Anagli, John] Henry Ford Hlth Syst, Detroit, MI USA.
[Rubenstein, Richard] Suny Downstate Med Ctr, Dept Neurol, Brooklyn, NY 11203 USA.
[Rubenstein, Richard] Suny Downstate Med Ctr, Dept Physiol & Pharmacol, Brooklyn, NY 11203 USA.
[Bahmad, Hisham] Beirut Arab Univ, Fac Med, Beirut, Lebanon.
[Bahmad, Hisham] Amer Univ Beirut, Fac Med, Dept Anat Cell Biol & Physiol Sci, Beirut, Lebanon.
[Wagner, Amy K.] Univ Pittsburgh, Dept Phys Med & Rehabil, Pittsburgh, PA USA.
[Wagner, Amy K.] Univ Pittsburgh, Safar Ctr Resuscitat Res, Pittsburgh, PA USA.
RP Wang, KKW (reprint author), Univ Florida, McKnight Brain Inst, Dept Psychiat, Program Neurotrauma Neuroprote & Biomarkers Res, Gainesville, FL USA.; Wang, KKW (reprint author), Univ Florida, McKnight Brain Inst, Dept Neurosci, Program Neurotrauma Neuroprote & Biomarkers Res, Gainesville, FL USA.
EM kawangwang17@gmail.com
RI kobeissy, firas/E-7042-2017
OI kobeissy, firas/0000-0002-5008-6944
FU Office of the Assistant Secretary of Defense for Health Affairs through
the US Army Medical Research and Materiel Command [W81XWH-07-1-070]
FX This work was supported by the Office of the Assistant Secretary of
Defense for Health Affairs through the US Army Medical Research and
Materiel Command under award #W81XWH-07-1-070 (AW). Opinions,
interpretations, conclusions, and recommendations are those of the
authors and are not necessarily endorsed by the DoD. In conducting
research using animals, the investigators adhere to the laws of the USA
and regulations of the Department of Agriculture. The funders had no
role in the study design, data collection and analysis, decision to
publish, or preparation of the manuscript.
NR 104
TC 0
Z9 0
U1 5
U2 5
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015,
SWITZERLAND
SN 1664-2295
J9 FRONT NEUROL
JI Front. Neurol.
PD NOV 22
PY 2016
VL 7
AR 198
DI 10.3389/fneur.2016.00198
PG 16
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA EC6EL
UT WOS:000388229200001
PM 27920753
ER
PT J
AU Cap, AP
AF Cap, Andrew P.
TI Plasmin: a driver of hemovascular dysfunction
SO BLOOD
LA English
DT Editorial Material
ID BRADYKININ; SYSTEM; EDEMA
C1 [Cap, Andrew P.] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
RP Cap, AP (reprint author), US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
NR 10
TC 0
Z9 0
U1 4
U2 4
PU AMER SOC HEMATOLOGY
PI WASHINGTON
PA 2021 L ST NW, SUITE 900, WASHINGTON, DC 20036 USA
SN 0006-4971
EI 1528-0020
J9 BLOOD
JI Blood
PD NOV 17
PY 2016
VL 128
IS 20
BP 2375
EP 2376
DI 10.1182/blood-2016-09-735720
PG 2
WC Hematology
SC Hematology
GA EC4LM
UT WOS:000388101600001
PM 27856467
ER
PT J
AU Shaha, JS
Cook, JB
Rowles, DJ
Bottoni, CR
Shaha, SH
Tokish, JM
AF Shaha, James S.
Cook, Jay B.
Rowles, Douglas J.
Bottoni, Craig R.
Shaha, Steven H.
Tokish, John M.
TI Clinical Validation of the Glenoid Track Concept in Anterior
Glenohumeral Instability
SO JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
LA English
DT Article
ID HILL-SACHS LESION; ARTHROSCOPIC BANKART REPAIR; SHOULDER INSTABILITY;
BONE LOSS; RISK-FACTORS; COMPUTED-TOMOGRAPHY; FUNCTIONAL OUTCOMES;
HUMERAL HEAD; DEFECT; STABILITY
AB Background: Glenoid and humeral bone loss are well-described risk factors for failure of arthroscopic shoulder stabilization. Recently, consideration of the interactions of these types of bone loss (bipolar bone loss) has been used to determine if a lesion is "on-track" or "off-track." The purpose of this study was to study the relationship of the glenoid track to the outcomes of arthroscopic Bankart reconstructions.
Methods: Over a 2-year period, 57 shoulders that were treated with an isolated, primary arthroscopic Bankart reconstruction performed at a single facility were included in this study. The mean patient age was 25.5 years (range, 20 to 42 years) at the time of the surgical procedure, and the mean follow-up was 48.3 months (range, 23 to 58 months). Preoperative magnetic resonance imaging was used to determine glenoid bone loss and Hill-Sachs lesion size and location and to measure the glenoid track to classify the shoulders as on-track or off-track. Outcomes were assessed according to shoulder stability on examination and subjective outcome.
Results: There were 10 recurrences (18%). Of the 49 on-track patients, 4 (8%) had treatment that failed compared with 6 (75%) of 8 off-track patients (p = 0.0001). Six (60%) of 10 patients with recurrence of instability were off-track compared with 2 (4%) of 47 patients in the stable group (p = 0.0001). The positive predictive value of an off-track measurement was 75% compared with 44% for the predictive value of glenoid bone loss of >20%.
Conclusions: The application of the glenoid track concept to our cohort was superior to using glenoid bone loss alone with regard to predicting postoperative stability. This method of assessment is encouraged as a routine part of the preoperative evaluation of all patients under consideration for arthroscopic anterior stabilization.
C1 [Shaha, James S.; Cook, Jay B.; Rowles, Douglas J.; Bottoni, Craig R.; Shaha, Steven H.; Tokish, John M.] Tripler Army Med Ctr, Honolulu, HI 96859 USA.
[Shaha, James S.; Cook, Jay B.; Bottoni, Craig R.] Tripler Army Med Ctr, Dept Orthopaed Surg, Honolulu, HI 96859 USA.
[Rowles, Douglas J.] Univ Oklahoma, Dept Orthopaed Surg, Norman, OK 73019 USA.
[Shaha, Steven H.] Univ Utah, Salt Lake City, UT USA.
[Tokish, John M.] Steadman Hawkins Clin Carolinas, Dept Orthopaed Surg, Greenville, SC USA.
RP Shaha, JS (reprint author), Tripler Army Med Ctr, Dept Orthopaed Surg, Honolulu, HI 96859 USA.
EM jshaha6@gmail.com
NR 27
TC 0
Z9 0
U1 0
U2 0
PU JOURNAL BONE JOINT SURGERY
PI NEEDHAM
PA 20 PICKERING ST, NEEDHAM, MA 02492 USA
SN 0021-9355
EI 1535-1386
J9 J BONE JOINT SURG AM
JI J. Bone Joint Surg.-Am. Vol.
PD NOV 16
PY 2016
VL 98
IS 22
DI 10.2106/JBJS.15.01099
PG 6
WC Orthopedics; Surgery
SC Orthopedics; Surgery
GA EN4AH
UT WOS:000395949000013
PM 27852909
ER
PT J
AU Thiemmeca, S
Tamdet, C
Punyadee, N
Prommool, T
Songjaeng, A
Noisakran, S
Puttikhunt, C
Atkinson, JP
Diamond, MS
Ponlawat, A
Avirutnan, P
AF Thiemmeca, Somchai
Tamdet, Chamaiporn
Punyadee, Nuntaya
Prommool, Tanapan
Songjaeng, Adisak
Noisakran, Sansanee
Puttikhunt, Chunya
Atkinson, John P.
Diamond, Michael S.
Ponlawat, Alongkot
Avirutnan, Panisadee
TI Secreted NS1 Protects Dengue Virus from Mannose-Binding Lectin-Mediated
Neutralization
SO JOURNAL OF IMMUNOLOGY
LA English
DT Article
ID N-LINKED GLYCOSYLATION; NONSTRUCTURAL PROTEIN-1 NS1; WEST-NILE-VIRUS;
MONOCLONAL-ANTIBODIES; INSECT CELLS; COMPLEMENT ACTIVATION;
ENDOTHELIAL-CELLS; VIRAL INFECTIVITY; MOSQUITO CELLS; C4B BINDING
AB Flavivirus nonstructural protein 1 (NS1) is a unique secreted nonstructural glycoprotein. Although it is absent from the flavivirus virion, intracellular and extracellular forms of NS1 have essential roles in viral replication and the pathogenesis of infection. The fate of NS1 in insect cells has been more controversial, with some reports suggesting it is exclusively cell associated. In this study, we confirm NS1 secretion from cells of insect origin and characterize its physical, biochemical, and functional properties in the context of dengue virus (DENV) infection. Unlike mammalian cell-derived NS1, which displays both high mannose and complex type N-linked glycans, soluble NS1 secreted from DENV-infected insect cells contains only high mannose glycans. Insect cell-derived secreted NS1 also has different physical properties, including smaller and more heterogeneous sizes and the formation of less stable NS1 hexamers. Both mammalian and insect cell-derived NS1 bind to complement proteins C1s, C4, and C4-binding protein, as well as to a novel partner, mannose-binding lectin. Binding of NS1 to MBL protects DENV against mannose-binding lectin-mediated neutralization by the lectin pathway of complement activation. As we detected secreted NS1 and DENV together in the saliva of infected Aedes aegypti mosquitoes, these findings suggest a mechanism of viral immune evasion at the very earliest phase of infection.
C1 [Thiemmeca, Somchai; Tamdet, Chamaiporn; Punyadee, Nuntaya; Songjaeng, Adisak; Noisakran, Sansanee; Puttikhunt, Chunya; Avirutnan, Panisadee] Mahidol Univ, Siriraj Hosp, Fac Med, Div Dengue Hemorrhag Fever Res,Dept Res & Dev, 2 Wanglang Rd,12th Floor,Adulyadejvikrom Bldg, Bangkok 10700, Thailand.
[Thiemmeca, Somchai] Mahidol Univ, Siriraj Hosp, Dept Immunol, Grad Program,Fac Med, Bangkok 10700, Thailand.
[Prommool, Tanapan; Noisakran, Sansanee; Puttikhunt, Chunya; Avirutnan, Panisadee] Natl Sci & Technol Dev Agcy, Med Biotechnol Res Unit, Natl Ctr Genet Engn & Biotechnol, Bangkok 12120, Thailand.
[Atkinson, John P.; Diamond, Michael S.] Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA.
[Atkinson, John P.; Diamond, Michael S.] Washington Univ, Sch Med, Dept Mol Microbiol, St Louis, MO 63110 USA.
[Diamond, Michael S.] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA.
[Ponlawat, Alongkot] Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand.
RP Avirutnan, P (reprint author), Mahidol Univ, Siriraj Hosp, Fac Med, Div Dengue Hemorrhag Fever Res,Dept Res & Dev, 2 Wanglang Rd,12th Floor,Adulyadejvikrom Bldg, Bangkok 10700, Thailand.
EM panisadee.avi@mahidol.ac.th
FU Faculty of Medicine Siriraj Hospital, Mahidol University [R015633003];
Thailand Research Fund [RSA 5680049]; National Institutes of Health [R01
AI077955]; Siriraj Chalermprakiat Grant from the Faculty of Medicine,
Siriraj Hospital, Mahidol University; Research Lecturer Grant from the
Faculty of Medicine, Siriraj Hospital, Mahidol University; Royal Golden
Jubilee Ph.D. Program [PHD/0101/2554]
FX This work was supported by Faculty of Medicine Siriraj Hospital, Mahidol
University Grant R015633003, Thailand Research Fund RSA 5680049 (to
P.A.), and National Institutes of Health Grant R01 AI077955 (to M.S.D.).
P.A. has been supported by a Siriraj Chalermprakiat Grant and a Research
Lecturer Grant from the Faculty of Medicine, Siriraj Hospital, Mahidol
University. S.T. is a Ph.D. scholar in the Royal Golden Jubilee Ph.D.
Program (PHD/0101/2554).
NR 56
TC 1
Z9 1
U1 4
U2 4
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD NOV 15
PY 2016
VL 197
IS 10
BP 4053
EP 4065
DI 10.4049/jimmunol.1600323
PG 13
WC Immunology
SC Immunology
GA EE5GW
UT WOS:000389634600029
PM 27798151
ER
PT J
AU Walsh, DV
Capo-Aponte, JE
Beltran, T
Cole, WR
Ballard, A
Dumayas, JY
AF Walsh, David V.
Capo-Aponte, Jose E.
Beltran, Thomas
Cole, Wesley R.
Ballard, Ashley
Dumayas, Joseph Y.
TI Assessment of the King-Devick (R) (KD) test for screening acute
mTBI/concussion in warfighters
SO JOURNAL OF THE NEUROLOGICAL SCIENCES
LA English
DT Article
DE King-Devick (KD) test; Saccades; Mild traumatic brain injury (mTBI);
Military
ID TRAUMATIC BRAIN-INJURY; KING-DEVICK TEST; RUGBY LEAGUE; RECOVERY;
REHABILITATION; CONCUSSION; SYMPTOMS; IRAQ
AB Objectives: The Department of Defense reported that 344,030 cases of traumatic brain injury (TBI) were clinically confirmed from 2000 to 2015, with mild TBI (mTBI) accounting for 82.3% of all cases. Unfortunately, warfighters with TBI are often identified only when moderate or severe head injuries have occurred, leaving more subtle mTBI cases undiagnosed. This study aims to identify and validate an eye-movement visual test for screening acute mTBI.
Methods: Two-hundred active duty military personnel were recruited to perform the King-Devick (R) (KD) test. Subjects were equally divided into two groups: those with diagnosed acute mTBI (<= 72 h) and age-matched controls. The KD test was administered twice for test-retest reliability, and the outcome measure was total cumulative time to complete each test.
Results: The mTBI group had approximately 36% mean slower performance time with significant differences between the groups (p < 0.001) in both tests. There were significant differences between the two KD test administrations in each group, however, a strong correlation was observed between each test administration.
Conclusions: Significant differences in KD test performance were seen between the acute mTBI and control groups. The results suggest the KD test can be utilized for screening acute mTBI. A validated and rapidly administered mTBI screening test with results that are easily interpreted by providers is essential in making return-to duty decisions in the injured warfighter. Published by Elsevier B.V.
C1 [Walsh, David V.] US Army Aeromed Res Lab, Vis Protect & Performance Div, 6901 Farrel Rd, Ft Rucker, AL 36362 USA.
[Capo-Aponte, Jose E.; Ballard, Ashley; Dumayas, Joseph Y.] Womack Army Med Ctr, Dept Optometry, 2817 Reilly Rd,Stop A, Ft Bragg, NC 28310 USA.
[Beltran, Thomas] Womack Army Med Ctr, Dept Clin Invest, 2817 Reilly Rd,Stop A, Ft Bragg, NC 28310 USA.
[Cole, Wesley R.] Womack Army Med Ctr, Def & Vet Brain Injury Ctr, Dept Brain Injury Med, 2817 Reilly Rd,Stop A, Ft Bragg, NC 28310 USA.
RP Walsh, DV (reprint author), US Army Aeromed Res Lab, Vis Protect & Performance Div, 6901 Farrel Rd, Ft Rucker, AL 36362 USA.
EM david.v.walsh.mil@mail.mil
FU Military Operational Medicine Research Program of the U.S. Army Medical
Research and Materiel Command (USAMRMC); Department of Defense Army
Rapid Innovation Fund Research Program of the Office of the
Congressionally Directed Medical Research Programs (CDMRP)
[W81XWH-14-C-0048]; Geneva Foundation; Defense and Veterans Brain Injury
Center (DVBIC)
FX This research was funded by the Military Operational Medicine Research
Program of the U.S. Army Medical Research and Materiel Command
(USAMRMC), and FY13 Department of Defense Army Rapid Innovation Fund
Research Program of the Office of the Congressionally Directed Medical
Research Programs (CDMRP) under contract No. W81XWH-14-C-0048. This
research was conducted with support from the Geneva Foundation as well
as the Defense and Veterans Brain Injury Center (DVBIC) and staffing
support from General Dynamics Information Technology.
NR 25
TC 1
Z9 1
U1 2
U2 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0022-510X
EI 1878-5883
J9 J NEUROL SCI
JI J. Neurol. Sci.
PD NOV 15
PY 2016
VL 370
BP 305
EP 309
DI 10.1016/j.jns.2016.09.014
PG 5
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA EB8FV
UT WOS:000387627800063
PM 27646958
ER
PT J
AU Telesford, QK
Lynall, ME
Vettel, J
Miller, MB
Grafton, ST
Bassett, DS
AF Telesford, Qawi K.
Lynall, Mary-Ellen
Vettel, Jean
Miller, Michael B.
Grafton, Scott T.
Bassett, Danielle S.
TI Detection of functional brain network reconfiguration during task-driven
cognitive states
SO NEUROIMAGE
LA English
DT Article
ID GRAPH-THEORETICAL ANALYSIS; SMALL-WORLD NETWORK; RESTING-STATE; DYNAMIC
RECONFIGURATION; CONNECTIVITY PATTERNS; COMMUNITY STRUCTURE;
DECISION-MAKING; FMRI DATA; TRACKING; SYSTEMS
AB Network science offers computational tools to elucidate the complex patterns of interactions evident in neuroimaging data. Recently, these tools have been used to detect dynamic changes in network connectivity that may occur at short time scales. The dynamics of fMRI connectivity, and how they differ across time scales, are far from understood. A simple way to interrogate dynamics at different time scales is to alter the size of the time window used to extract sequential (or rolling) measures of functional connectivity. Here, in n = 82 participants performing three distinct cognitive visual tasks in recognition memory and strategic attention, we subdivided regional BOLD time series into variable sized time windows and determined the impact of time window size on observed dynamics. Specifically, we applied a multilayer community detection algorithm to identify temporal communities and we calculated network flexibility to quantify changes in these communities over time. Within our frequency band of interest, large and small windows were associated with a narrow range of network flexibility values across the brain, while medium time windows were associated with a broad range of network flexibility values. Using medium time windows of size 75-100 s, we uncovered brain regions with low flexibility (considered core regions, and observed in visual and attention areas) and brain regions with high flexibility (considered periphery regions, and observed in subcortical and temporal lobe regions) via comparison to appropriate dynamic network null models. Generally, this work demonstrates the impact of time window length on observed network dynamics during task performance, offering pragmatic considerations in the choice of time window in dynamic network analysis. More broadly, this work reveals organizational principles of brain functional connectivity that are not accessible with static network approaches. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Telesford, Qawi K.; Bassett, Danielle S.] Univ Penn, Dept Bioengn, 210 S 33rd St,240, Philadelphia, PA 19104 USA.
[Telesford, Qawi K.; Vettel, Jean] US Army, Res Lab, Aberdeen Proving Ground, MD 21001 USA.
[Lynall, Mary-Ellen] Univ Cambridge, Dept Psychiat, Cambridge, England.
[Lynall, Mary-Ellen; Vettel, Jean; Miller, Michael B.; Grafton, Scott T.] Univ Calif Santa Barbara, Dept Psychol & Brain Sci, Santa Barbara, CA 93106 USA.
[Bassett, Danielle S.] Univ Penn, Dept Elect & Syst Engn, Philadelphia, PA 19104 USA.
RP Bassett, DS (reprint author), Univ Penn, Dept Bioengn, 210 S 33rd St,240, Philadelphia, PA 19104 USA.
EM dsb@seas.upenn.edu
FU John D. and Catherine T. MacArthur Foundation; Alfred P. Sloan
Foundation; Office of Naval Research; Army Research Laboratory
[W911NF-10- 2-0022]; Army Research Office [W911NF-14-1-0679]; National
Science Foundation [PHY-1554488, BCS-1441502, BCS-1430087]; National
Institutes of Health [NIH R01-HD086888]
FX This work was supported by the John D. and Catherine T. MacArthur
Foundation, the Alfred P. Sloan Foundation, the Office of Naval
Research, the Army Research Laboratory through contract no. W911NF-10-
2-0022, the Army Research Office through contract no. W911NF-14-1-0679,
the National Science Foundation award PHY-1554488, BCS-1441502, and
BCS-1430087, and the National Institutes of Health through NIH
R01-HD086888.
NR 88
TC 2
Z9 2
U1 9
U2 9
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1053-8119
EI 1095-9572
J9 NEUROIMAGE
JI Neuroimage
PD NOV 15
PY 2016
VL 142
BP 188
EP 200
DI 10.1016/j.neuroimage.2016.05.078
PG 13
WC Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical
Imaging
SC Neurosciences & Neurology; Radiology, Nuclear Medicine & Medical Imaging
GA EC2WW
UT WOS:000387986000015
PM 27261162
ER
PT J
AU Kumar, N
Mishra, RS
Dahotre, NB
Brennan, RE
Doherty, KJ
Cho, KC
AF Kumar, N.
Mishra, R. S.
Dahotre, N. B.
Brennan, R. E.
Doherty, K. J.
Cho, K. C.
TI Effect of friction stir processing on microstructure and mechanical
properties of laser-processed Mg-4Y-3Nd alloy
SO MATERIALS & DESIGN
LA English
DT Article
DE Laser processing; Friction stir processing; Mechanical properties;
Ductility; Magnesium alloy
ID ND-ZR ALLOY; MAGNESIUM ALLOYS; WROUGHT MAGNESIUM; EVOLUTION;
PRECIPITATION; SHEETS
AB The development of advanced structural materials is dependent, among many factors, on the choice of manufacturing processes. Laser processing and friction stir processing (FSP) are two such advanced manufacturing processes. Individually, they have been studied quite extensively to understand their potential for developing high efficiency structures. However, there is no study describing the sequential integration of laser processing and FSP on microstructure and mechanical properties. The present study deals with FSP of the laser processed Mg-4Y-3Nd (WE43) alloy. The laser surface melting was carried out in air at 1800 W laser power, 30 mm/s laser speed, and 0.6 mm spot size on the surface using continuous wave Nd:YAG fiber laser followed by FSP of laser processed region at 500 rpm and 4 ipm. Scanning electron microscopy, electron backscatter diffraction, and transmission electron microscopy were carried out to understand microstructural evolution within the laser melted and friction stir processed regions. Mechanical properties were evaluated using uniaxial tensile testing at a strain-rate of 10(-3) s(-1). FSP led to significant improvement in strength and ductility of the laser processed material. An analysis of the strengthening mechanisms revealed that the dominant strengthening mechanism(s) in the WE43 alloy was dependent on the processing step. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Kumar, N.; Mishra, R. S.] Univ North Texas, Dept Mat Sci & Engn, Ctr Frict Stir Proc, Denton, TX 76203 USA.
[Dahotre, N. B.] Univ North Texas, Dept Mat Sci & Engn, Denton, TX 76203 USA.
[Brennan, R. E.; Doherty, K. J.; Cho, K. C.] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA.
[Kumar, N.] North Carolina State Univ, Dept Nucl Engn, Raleigh, NC 27607 USA.
RP Mishra, RS (reprint author), Univ North Texas, Dept Mat Sci & Engn, Ctr Frict Stir Proc, Denton, TX 76203 USA.
EM nkumar7@ncsu.edu; Rajiv.Mishra@unt.edu
RI Mishra, Rajiv/A-7985-2009
OI Mishra, Rajiv/0000-0002-1699-0614
FU Army Research Laboratory; University of North Texas [W911NF-13-2-0018]
FX The work was performed under a cooperative agreement between the Army
Research Laboratory and the University of North Texas
(W911NF-13-2-0018). The authors are thankful to the Center for Advanced
Research and Technology (CART) for providing access to the microscopy
facilities at the University of North Texas. The authors are also
grateful to Mr. Rick DeLorme and Dr. Bruce Davis of Magnesium Elektron
NA for providing the WE43 alloy.
NR 28
TC 0
Z9 0
U1 18
U2 18
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0264-1275
EI 1873-4197
J9 MATER DESIGN
JI Mater. Des.
PD NOV 15
PY 2016
VL 110
BP 663
EP 675
DI 10.1016/j.matdes.2016.08.039
PG 13
WC Materials Science, Multidisciplinary
SC Materials Science
GA DZ1LV
UT WOS:000385600800072
ER
PT J
AU Reddy, P
Hoffmann, MP
Kaess, F
Bryan, Z
Bryan, I
Bobea, M
Klump, A
Tweedie, J
Kirste, R
Mita, S
Gerhold, M
Collazo, R
Sitar, Z
AF Reddy, P.
Hoffmann, M. P.
Kaess, F.
Bryan, Z.
Bryan, I.
Bobea, M.
Klump, A.
Tweedie, J.
Kirste, R.
Mita, S.
Gerhold, M.
Collazo, R.
Sitar, Z.
TI Point defect reduction in wide bandgap semiconductors by defect quasi
Fermi level control
SO JOURNAL OF APPLIED PHYSICS
LA English
DT Article
ID GAN; ALGAN; ZNO
AB A theoretical framework for a general approach to reduce point defect density in materials via control of defect quasi Fermi level (dQFL) is presented. The control of dQFL is achieved via excess minority carrier generation. General guidelines for controlling dQFL that lead to a significant reduction in compensating point defects in any doped material is proposed. The framework introduces and incorporates the effects of various factors that control the efficacy of the defect reduction process such as defect level, defect formation energy, bandgap, and excess minority carrier density. Modified formation energy diagrams are proposed, which illustrate the effect of the quasi Fermi level control on the defect formation energies. These formation energy diagrams provide powerful tools to determine the feasibility and requirements to produce the desired reduction in specified point defects. An experimental study of the effect of excess minority carriers on point defect incorporation in GaN and AlGaN shows an excellent quantitative agreement with the theoretical predictions. Illumination at energies larger than the bandgap is employed as a means to generate excess minority carriers. The case studies with C-N in Si doped GaN, H and V-N in Mg doped GaN and V-M-2O(N) in Si doped Al0.65Ga0.35N revealed a significant reduction in impurities in agreement with the proposed theory. Since compensating point defects control the material performance (this is particularly challenging in wide and ultra wide bandgap materials), dQFL control is a highly promising technique with wide scope and may be utilized to improve the properties of various materials systems and performance of devices based upon them. Published by AIP Publishing.
C1 [Reddy, P.; Hoffmann, M. P.; Kaess, F.; Bryan, Z.; Bryan, I.; Bobea, M.; Klump, A.; Collazo, R.; Sitar, Z.] North Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA.
[Reddy, P.; Tweedie, J.; Kirste, R.; Mita, S.; Sitar, Z.] Adroit Mat Inc, 2054 Kildaire Farm Rd, Cary, NC 27518 USA.
[Gerhold, M.] Army Res Off, Engn Sci Directorate, POB 12211, Res Triangle Pk, NC 27703 USA.
RP Reddy, P (reprint author), North Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA.; Reddy, P (reprint author), Adroit Mat Inc, 2054 Kildaire Farm Rd, Cary, NC 27518 USA.
OI Reddy, Pramod/0000-0002-8556-1178
FU NSF [DMR-1108071, DMR-1508191, DMR-1312582, ECCS-1508854]; ARO
[W911NF-04-D-0003, W911NF-14-C-0008]; ARPA-E [DE-AR0000299]; GAANN
Fellowship; NDSEG Fellowship
FX The authors thank Fred Stevie and his co-workers from the Analytical
Instrumentation Facility at the North Carolina State University for
their great contribution by the SIMS analysis of our samples. Partial
financial support from NSF (DMR-1108071, DMR-1508191, DMR-1312582 and
ECCS-1508854), ARO (W911NF-04-D-0003 and W911NF-14-C-0008), ARPA-E
(DE-AR0000299), GAANN Fellowship, and NDSEG Fellowship was greatly
appreciated. Part of this research was performed while the second author
held a National Research Council Research Associateship Award.
NR 28
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Z9 1
U1 8
U2 8
PU AMER INST PHYSICS
PI MELVILLE
PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA
SN 0021-8979
EI 1089-7550
J9 J APPL PHYS
JI J. Appl. Phys.
PD NOV 14
PY 2016
VL 120
IS 18
AR 185704
DI 10.1063/1.4967397
PG 10
WC Physics, Applied
SC Physics
GA ED3FK
UT WOS:000388734700033
ER
PT J
AU Elliott, MH
Ashpole, NE
Gu, XW
Herrnberger, L
McClellan, ME
Griffith, GL
Reagan, AM
Boyce, TM
Tanito, M
Tamm, ER
Stamer, WD
AF Elliott, Michael H.
Ashpole, Nicole E.
Gu, Xiaowu
Herrnberger, Leonie
McClellan, Mark E.
Griffith, Gina L.
Reagan, Alaina M.
Boyce, Timothy M.
Tanito, Masaki
Tamm, Ernst R.
Stamer, W. Daniel
TI Caveolin-1 modulates intraocular pressure: implications for caveolae
mechanoprotection in glaucoma
SO SCIENTIFIC REPORTS
LA English
DT Article
ID OPEN-ANGLE GLAUCOMA; TRABECULAR MESHWORK CELLS; CANAL ENDOTHELIAL-CELLS;
NITRIC-OXIDE; NONHUMAN PRIMATE; COMMON VARIANTS; PLASMA-MEMBRANE;
SKELETAL-MUSCLE; AQUEOUS OUTFLOW; PORE DENSITY
AB Polymorphisms in the CAV1/2 genes that encode signature proteins of caveolae are associated with glaucoma, the second leading cause of blindness worldwide, and with its major risk factor, intraocular pressure (IOP). We hypothesized that caveolin-1 (Cav-1) participates in IOP maintenance via modulation of aqueous humor drainage from the eye. We localize caveolae proteins to human and murine conventional drainage tissues and show that caveolae respond to mechanical stimulation. We show that Cav-1-deficient (Cav-1(-/-)) mice display ocular hypertension explained by reduced pressure-dependent drainage of aqueous humor. Cav-1 deficiency results in loss of caveolae in the Schlemm's canal (SC) and trabecular meshwork. However, their absence did not appear to impact development nor adult form of the conventional outflow tissues according to rigorous quantitative ultrastructural analyses, but did affect cell and tissue behavior. Thus, when IOP is experimentally elevated, cells of the Cav-1(-/-) outflow tissues are more susceptible to plasma membrane rupture indicating that caveolae play a role in mechanoprotection. Additionally, aqueous drainage from Cav-1(-/-) eyes was more sensitive to nitric oxide (NO) synthase inhibition than controls, suggesting that excess NO partially compensates for outflow pathway dysfunction. These results provide a functional link between a glaucoma risk gene and glaucoma-relevant pathophysiology.
C1 [Elliott, Michael H.; Gu, Xiaowu; McClellan, Mark E.; Griffith, Gina L.; Reagan, Alaina M.; Boyce, Timothy M.] Univ Oklahoma, Hlth Sci Ctr, Dean McGee Eye Inst, Dept Ophthalmol, Oklahoma City, OK 73104 USA.
[Ashpole, Nicole E.; Stamer, W. Daniel] Duke Univ, Dept Ophthalmol, Duke Eye Ctr, Durham, NC 27710 USA.
[Herrnberger, Leonie; Tamm, Ernst R.] Univ Regensburg, Inst Human Anat & Embryol, D-93053 Regensburg, Germany.
[Tanito, Masaki] Matsue Red Cross Hosp, Div Ophthalmol, Matsue, Shimane 6908506, Japan.
[Gu, Xiaowu] Johns Hopkins Univ, Sch Med, Dept Mol Biol & Genet, Baltimore, MD 21205 USA.
[Griffith, Gina L.] US Army Inst Surg Res, Ocular Trauma & Vis Restorat, Ft Sam Houston, TX 78234 USA.
[Boyce, Timothy M.] Oregon Hlth & Sci Univ, Sch Med, Dept Ophthalmol, Casey Eye Inst, Portland, OR 97239 USA.
RP Elliott, MH (reprint author), Univ Oklahoma, Hlth Sci Ctr, Dean McGee Eye Inst, Dept Ophthalmol, Oklahoma City, OK 73104 USA.; Stamer, WD (reprint author), Duke Univ, Dept Ophthalmol, Duke Eye Ctr, Durham, NC 27710 USA.
EM michael-elliott@ouhsc.edu; dan.stamer@duke.edu
FU BrightFocus Foundation [G2013092]; Alcon Research Institute by NIH
[R01-EY019494, P30-EY021725, T32-EY023202, R01-EY022359, P30EY005722];
Research to Prevent Blindness
FX This work was supported by BrightFocus Foundation grant G2013092
(M.H.E.), the Alcon Research Institute (M.H.E.) by NIH grants
R01-EY019494 (M.H.E.), P30-EY021725 (Core Grant, OUHSC), T32-EY023202
(Training Grant, OUHSC) R01-EY022359 (W.D.S.), P30EY005722 (Core Grant,
Duke Eye Center) and an unrestricted grant (Dean McGee Eye Institute)
and Senior Investigator award (W.D.S.) from Research to Prevent
Blindness.
NR 60
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Z9 0
U1 1
U2 1
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD NOV 14
PY 2016
VL 6
AR 37127
DI 10.1038/srep37127
PG 12
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA EC1GL
UT WOS:000387852800001
PM 27841369
ER
PT J
AU Rudraswami, NG
Prasad, MS
Dey, S
Fernandes, D
Plane, JMC
Feng, W
Taylor, S
Carrillo-Sanchez, JD
AF Rudraswami, N. G.
Prasad, M. Shyam
Dey, S.
Fernandes, D.
Plane, J. M. C.
Feng, W.
Taylor, S.
Carrillo-Sanchez, J. D.
TI RELICT OLIVINES IN MICROMETEORITES: PRECURSORS AND INTERACTIONS IN THE
EARTH'S ATMOSPHERE
SO ASTROPHYSICAL JOURNAL
LA English
DT Article
DE atmospheric effects; Earth; interplanetary medium; minor planets,
asteroids: general; Sun: general
ID COSMIC SPHERULES; ACCRETION RATE; ANTARCTIC MICROMETEORITES;
CARBONACEOUS CHONDRITES; ELEMENTAL COMPOSITION; SOLAR NEBULA;
CHONDRULES; DUST; GRAINS; FORSTERITE
AB Antarctica micrometeorites (similar to 1200) and cosmic spherules (similar to 5000) from deep sea sediments are studied using electron microscopy to identify Mg-rich olivine grains in order to determine the nature of the particle precursors. Mg-rich olivine (FeO < 5wt%) in micrometeorites suffers insignificant chemical modification during its history and is a well-preserved phase. We examine 420. forsterite grains enclosed in 162 micrometeorites of different types -unmelted, scoriaceous, and porphyritic-in this study. Forsterites in micrometeorites of different types are crystallized during their formation in solar nebula; their closest analogues are chondrule components of CV-type chondrites or volatile rich CM chondrites. The forsteritic olivines are suggested to have originated from a cluster of closely related carbonaceous asteroids that have Mg-rich olivines in the narrow range of CaO (0.1-0.3wt%), Al2O3 (0.0-0.3wt%), MnO (0.0-0.3wt%), and Cr2O3 (0.1-0.7wt%). Numerical simulations carried out with the Chemical Ablation Model (CABMOD) enable us to define the physical conditions of atmospheric entry that preserve the original compositions of the Mg-rich olivines in these particles. The chemical compositions of relict olivines affirm the role of heating at peak temperatures and the cooling rates of the micrometeorites. This modeling approach provides a foundation for understanding the ablation of the particles and the circumstances in which the relict grains tend to survive.
C1 [Rudraswami, N. G.; Prasad, M. Shyam; Dey, S.; Fernandes, D.] Natl Inst Oceanog, Council Sci & Ind Res, Panaji 403004, Goa, India.
[Dey, S.] Indian Inst Technol, Roorkee 247667, Uttarakhand, India.
[Plane, J. M. C.; Feng, W.; Carrillo-Sanchez, J. D.] Univ Leeds, Sch Chem, Leeds LS2 9JT, W Yorkshire, England.
[Taylor, S.] Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA.
RP Rudraswami, NG (reprint author), Natl Inst Oceanog, Council Sci & Ind Res, Panaji 403004, Goa, India.
EM rudra@nio.org
RI Plane, John/C-7444-2015;
OI Plane, John/0000-0003-3648-6893; N G, Rudraswami/0000-0002-3375-9860;
Dey, Supratim/0000-0002-1354-5304
FU CSIR XII Plan; PLANEX project, Physical Research Laboratory, Ahmedabad;
European Research Council [291332-CODITA]; National Science Foundation
FX This work is supported by the CSIR XII Plan funded Project GEOSINKS and
the PLANEX project, Physical Research Laboratory, Ahmedabad (NGR and
MSP). We thank Vijay Khedekar for his support in EPMA and electron
microscopy. The CABMOD model development is supported by the European
Research Council (project 291332-CODITA). The National Science
Foundation funded the collection of micro-meteorites from the South Pole
water well. This is NIO's contribution No. 5941.
NR 48
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U1 3
U2 3
PU IOP PUBLISHING LTD
PI BRISTOL
PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
SN 0004-637X
EI 1538-4357
J9 ASTROPHYS J
JI Astrophys. J.
PD NOV 10
PY 2016
VL 831
IS 2
AR 197
DI 10.3847/0004-637X/831/2/197
PG 10
WC Astronomy & Astrophysics
SC Astronomy & Astrophysics
GA EL7EW
UT WOS:000394784900001
ER
PT J
AU Aguilar, CA
Pop, R
Shcherbina, A
Watts, A
Matheny, RW
Cacchiarelli, D
Han, WM
Shin, E
Nakhai, SA
Jang, YC
Carrigan, CT
Gifford, CA
Kottke, MA
Cesana, M
Lee, J
Urso, ML
Meissner, A
AF Aguilar, Carlos A.
Pop, Ramona
Shcherbina, Anna
Watts, Alain
Matheny, Ronald W., Jr.
Cacchiarelli, Davide
Han, Woojin M.
Shin, Eunjung
Nakhai, Shadi A.
Jang, Young C.
Carrigan, Christopher T.
Gifford, Casey A.
Kottke, Melissa A.
Cesana, Marcella
Lee, Jackson
Urso, Maria L.
Meissner, Alexander
TI Transcriptional and Chromatin Dynamics of Muscle Regeneration after
Severe Trauma
SO STEM CELL REPORTS
LA English
DT Article
ID LONG NONCODING RNA; DUCHENNE MUSCULAR-DYSTROPHY; CELL-CYCLE ARREST;
SKELETAL-MUSCLE; SATELLITE CELL; MYOGENIC DIFFERENTIATION; STEM-CELLS;
INFLAMMATORY MONOCYTES; REGULATORY NETWORKS; PI3K P110-ALPHA
AB Following injury, adult skeletal muscle undergoes a well-coordinated sequence of molecular and physiological events to promote repair and regeneration. However, a thorough understanding of the in vivo epigenomic and transcriptional mechanisms that control these reparative events is lacking. To address this, we monitored the in vivo dynamics of three histone modifications and coding and non-coding RNA expression throughout the regenerative process in a mouse model of traumatic muscle injury. We first illustrate how both coding and noncoding RNAs in tissues and sorted satellite cells are modified and regulated during various stages after trauma. Next, we use chromatin immunoprecipitation followed by sequencing to evaluate the chromatin state of cis-regulatory elements (promoters and enhancers) and view how these elements evolve and influence various muscle repair and regeneration transcriptional programs. These results provide a comprehensive view of the central factors that regulate muscle regeneration and underscore the multiple levels through which both transcriptional and epigenetic patterns are regulated to enact appropriate repair and regeneration.
C1 [Aguilar, Carlos A.; Shcherbina, Anna; Watts, Alain; Lee, Jackson] MIT, Lincoln Lab, Lexington, MA 02127 USA.
[Pop, Ramona; Cacchiarelli, Davide; Gifford, Casey A.; Meissner, Alexander] Broad Inst MIT & Harvard, Cambridge, MA 02142 USA.
[Pop, Ramona; Cacchiarelli, Davide; Gifford, Casey A.; Meissner, Alexander] Harvard Univ, Harvard Stem Cell Inst, Dept Stem Cell & Regenerat Biol, Cambridge, MA 02138 USA.
[Matheny, Ronald W., Jr.; Carrigan, Christopher T.; Kottke, Melissa A.; Urso, Maria L.] US Army, Mil Performance Div, Inst Environm Med, Natick, MA 01760 USA.
[Han, Woojin M.] Georgia Inst Technol, Woodruff Sch Mech Engn, Atlanta, GA 30332 USA.
[Han, Woojin M.; Shin, Eunjung; Nakhai, Shadi A.; Jang, Young C.] Georgia Inst Technol, Parker H Petit Inst Bioengn & Biosci, Atlanta, GA 30332 USA.
[Shin, Eunjung; Nakhai, Shadi A.; Jang, Young C.] Georgia Inst Technol, Sch Biol Sci, Atlanta, GA 30332 USA.
[Nakhai, Shadi A.; Jang, Young C.] Georgia Inst Technol, Wallace Coulter Dept Biomed Engn, Atlanta, GA 30332 USA.
[Cesana, Marcella] Harvard Med Sch, Boston Childrens Hosp, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA.
RP Aguilar, CA (reprint author), MIT, Lincoln Lab, Lexington, MA 02127 USA.
EM carlos.aguilar@ll.mit.edu
FU Air Force [FA8721-05-C-0002, FA8702-15-D-0001]
FX The authors thank Chet Beal for assistance with artwork, Sara Chauvin,
Patrick Boyle, Fontina Kelley, and the Broad Institute Genomics Platform
for sequencing and technical assistance, Tara Boettcher for assistance
with ChIP and sequencing library preparation, Mary Abdalla, Christina
Zook, and Alyssa Geddis for technical assistance with PCR, and Darrell
O. Ricke and Michael J. Ziller for insightful discussions. This material
is based upon work supported under Air Force Contract No.
FA8721-05-C-0002 and/or FA8702-15-D-0001. Opinions, interpretations,
recommendations, and conclusions are those of the authors and are not
necessarily endorsed by the United States Government. Any opinions,
findings, conclusions, or recommendations expressed in this material are
those of the author(s) and do not necessarily reflect the views of the
U.S. Air Force. C.C. was supported by an appointment to the postgraduate
research participation program at the US Army Research Institute of
Environmental Medicine, administered by the Oak Ridge Institute for
Science and Education through an interagency agreement between the US
Department of Energy and the US Army Medical Research and Materiel
Command. The views, opinions, and/or findings of this report are those
of the authors and should not be construed as an official US Department
of the Army position, policy, or decision unless so designated by other
official documentation.
NR 69
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U1 0
U2 0
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 2213-6711
J9 STEM CELL REP
JI Stem Cell Rep.
PD NOV 8
PY 2016
VL 7
IS 5
BP 983
EP 997
DI 10.1016/j.stemcr.2016.09.009
PG 15
WC Cell & Tissue Engineering; Cell Biology
SC Cell Biology
GA EE3QH
UT WOS:000389509000013
PM 27773702
ER
PT J
AU Gu, Z
Churchman, M
Roberts, K
Li, Y
Liu, Y
Harvey, RC
McCastlain, K
Reshmi, SC
Payne-Turner, D
Iacobucci, I
Shao, Y
Chen, IM
Valentine, M
Pei, D
Mungall, KL
Mungall, AJ
Ma, Y
Moore, R
Marra, M
Stonerock, E
Gastier-Foster, JM
Devidas, M
Dai, Y
Wood, B
Borowitz, M
Larsen, EE
Maloney, K
Mattano, LA
Angiolillo, A
Salzer, WL
Burke, MJ
Gianni, F
Spinelli, O
Radich, JP
Minden, MD
Moorman, AV
Patel, B
Fielding, AK
Rowe, JM
Luger, SM
Bhatia, R
Aldoss, I
Forman, SJ
Kohlschmidt, J
Mrozek, K
Marcucci, G
Bloomfield, CD
Stock, W
Kornblau, S
Kantarjian, HM
Konopleva, M
Paietta, E
Willman, CL
Loh, ML
Hunger, SP
Mullighan, CG
AF Gu, Zhaohui
Churchman, Michelle
Roberts, Kathryn
Li, Yongjin
Liu, Yu
Harvey, Richard C.
McCastlain, Kelly
Reshmi, Shalini C.
Payne-Turner, Debbie
Iacobucci, Ilaria
Shao, Ying
Chen, I-Ming
Valentine, Marcus
Pei, Deqing
Mungall, Karen L.
Mungall, Andrew J.
Ma, Yussanne
Moore, Richard
Marra, Marco
Stonerock, Eileen
Gastier-Foster, Julie M.
Devidas, Meenakshi
Dai, Yunfeng
Wood, Brent
Borowitz, Michael
Larsen, Eric E.
Maloney, Kelly
Mattano, Leonard A., Jr.
Angiolillo, Anne
Salzer, Wanda L.
Burke, Michael J.
Gianni, Francesca
Spinelli, Orietta
Radich, Jerald P.
Minden, Mark D.
Moorman, Anthony V.
Patel, Bella
Fielding, Adele K.
Rowe, Jacob M.
Luger, Selina M.
Bhatia, Ravi
Aldoss, Ibrahim
Forman, Stephen J.
Kohlschmidt, Jessica
Mrozek, Krzysztof
Marcucci, Guido
Bloomfield, Clara D.
Stock, Wendy
Kornblau, Steven
Kantarjian, Hagop M.
Konopleva, Marina
Paietta, Elisabeth
Willman, Cheryl L.
Loh, Mignon L.
Hunger, Stephen P.
Mullighan, Charles G.
TI Genomic analyses identify recurrent MEF2D fusions in acute lymphoblastic
leukaemia
SO NATURE COMMUNICATIONS
LA English
DT Article
ID FORKHEAD BOX J2; GENE-EXPRESSION; BREAST-CANCER; PROTEINS; RISK;
IDENTIFICATION; TRANSFORMATION; MEF2D/DAZAP1; MIGRATION; PROGNOSIS
AB Chromosomal rearrangements are initiating events in acute lymphoblastic leukaemia (ALL). Here using RNA sequencing of 560 ALL cases, we identify rearrangements between MEF2D (myocyte enhancer factor 2D) and five genes (BCL9, CSF1R, DAZAP1, HNRNPUL1 and SS18) in 22 B progenitor ALL (B-ALL) cases with a distinct gene expression profile, the most common of which is MEF2D-BCL9. Examination of an extended cohort of 1,164 B-ALL cases identified 30 cases with MEF2D rearrangements, which include an additional fusion partner, FOXJ2; thus, MEF2D-rearranged cases comprise 5.3% of cases lacking recurring alterations. MEF2D-rearranged ALL is characterized by a distinct immunophenotype, DNA copy number alterations at the rearrangement sites, older diagnosis age and poor outcome. The rearrangements result in enhanced MEF2D transcriptional activity, lymphoid transformation, activation of HDAC9 expression and sensitive to histone deacetylase inhibitor treatment. Thus, MEF2D-rearranged ALL represents a distinct form of high-risk leukaemia, for which new therapeutic approaches should be considered.
C1 [Gu, Zhaohui; Churchman, Michelle; Roberts, Kathryn; McCastlain, Kelly; Payne-Turner, Debbie; Iacobucci, Ilaria; Shao, Ying; Mullighan, Charles G.] St Jude Childrens Res Hosp, Dept Pathol, 262 Danny Thomas Pl,MS 342, Memphis, TN 38105 USA.
[Gu, Zhaohui; Churchman, Michelle; Roberts, Kathryn; McCastlain, Kelly; Payne-Turner, Debbie; Iacobucci, Ilaria; Shao, Ying; Mullighan, Charles G.] St Jude Childrens Res Hosp, Hematol Malignancies Program, 262 Danny Thomas Pl,MS 342, Memphis, TN 38105 USA.
[Li, Yongjin; Liu, Yu; Shao, Ying] St Jude Childrens Res Hosp, Dept Computat Biol, 332 N Lauderdale St, Memphis, TN 38105 USA.
[Harvey, Richard C.; Chen, I-Ming; Willman, Cheryl L.] Univ New Mexico, Ctr Canc, Albuquerque, NM 87106 USA.
[Reshmi, Shalini C.] Nationwide Childrens Hosp, Res Inst, Columbus, OH 43205 USA.
[Valentine, Marcus] St Jude Childrens Res Hosp, Cytogenet Shared Resource, 332 N Lauderdale St, Memphis, TN 38105 USA.
[Pei, Deqing] St Jude Childrens Res Hosp, Dept Biostat, 332 N Lauderdale St, Memphis, TN 38105 USA.
[Mungall, Karen L.; Mungall, Andrew J.; Ma, Yussanne; Moore, Richard; Marra, Marco] BC Canc Agcy, Canadas Michael Smith Genome Sci Ctr, Vancouver, BC V5Z 4S6, Canada.
[Stonerock, Eileen; Gastier-Foster, Julie M.] Nationwide Childrens Hosp, Dept Pathol & Lab Med, Columbus, OH 43205 USA.
[Stonerock, Eileen; Gastier-Foster, Julie M.] Ohio State Univ, Coll Med, Dept Pathol, Columbus, OH 43210 USA.
[Stonerock, Eileen; Gastier-Foster, Julie M.] Ohio State Univ, Dept Pediat, Coll Med, Columbus, OH 43210 USA.
[Devidas, Meenakshi; Dai, Yunfeng] Univ Florida, Dept Biostat, Coll Med, Gainesville, FL 32611 USA.
[Devidas, Meenakshi; Dai, Yunfeng] Univ Florida, Dept Biostat, Coll Publ Hlth & Hlth Profess, Gainesville, FL 32611 USA.
[Wood, Brent] Univ Washington, Dept Lab Med, Seattle, WA 98195 USA.
[Borowitz, Michael] Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21287 USA.
[Larsen, Eric E.] Maine Childrens Canc Program, Scarborough, ME 04074 USA.
[Maloney, Kelly] Univ Colorado, Sch Med, Pediat Hematol Oncol BMT, Aurora, CO 80045 USA.
[Maloney, Kelly] Childrens Hosp Colorado, Aurora, CO 80045 USA.
[Mattano, Leonard A., Jr.] HARP Pharma Consulting, Mystic, CT 06355 USA.
[Angiolillo, Anne] Childrens Natl Med Ctr, Washington, DC 20010 USA.
[Salzer, Wanda L.] US Army, Med Res & Mat Command, Ft Detrick, MD 21702 USA.
[Burke, Michael J.] Med Coll Wisconsin, Milwaukee, WI 53226 USA.
[Gianni, Francesca; Spinelli, Orietta] Papa Giovanni XXIII Hosp Piazza OMS 1, Dept Hematol & Bone Marrow Transplantat, I-24127 Bergamo, Italy.
[Radich, Jerald P.] Fred Hutchinson Canc Res Ctr, Seattle, WA 98109 USA.
[Minden, Mark D.] Univ Hlth Network, Princess Margaret Canc Ctr, Toronto, ON M5G 2M9, Canada.
[Moorman, Anthony V.] Newcastle Univ, Leukemia Res Cytogenet Grp, Northern Inst Canc Res, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England.
[Patel, Bella] Barts Canc Inst, Dept Haematooncol, London EC1M 6BQ, England.
[Fielding, Adele K.] UCL Canc Inst, Dept Hematol, London WC1E 6BT, England.
[Rowe, Jacob M.] Shaare Zedek Med Ctr, Hematol, IL-9103102 Jerusalem, Israel.
[Luger, Selina M.] Univ Penn, Abramson Canc Ctr, Philadelphia, PA 19104 USA.
[Bhatia, Ravi; Aldoss, Ibrahim] Univ Alabama Birmingham, Dept Med, Div Hematol & Oncol, Birmingham, AL 35294 USA.
[Forman, Stephen J.; Marcucci, Guido] City Hope Natl Med Ctr, Gehr Family Ctr Leukemia Res, Duarte, CA 91010 USA.
[Kohlschmidt, Jessica; Mrozek, Krzysztof; Bloomfield, Clara D.] Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA.
[Kohlschmidt, Jessica] Mayo Clin, Alliance Clin Trials Oncol Stat, Rochester, MN 55905 USA.
[Kohlschmidt, Jessica] Mayo Clin, Ctr Data, Rochester, MN 55905 USA.
[Stock, Wendy] Univ Chicago, Med Ctr, Chicago, IL 60637 USA.
[Kornblau, Steven; Kantarjian, Hagop M.; Konopleva, Marina] Univ Texas MD Anderson Canc Ctr, Dept Leukemia, Houston, TX 77030 USA.
[Paietta, Elisabeth] Montefiore Med Ctr, Ctr Canc, North Div, 111 E 210th St, Bronx, NY 10467 USA.
[Loh, Mignon L.] Benioff Childrens Hosp, Dept Pediat, San Francisco, CA 94158 USA.
[Loh, Mignon L.] Helen Diller Family Comprehens Canc Ctr, San Francisco, CA 94115 USA.
[Hunger, Stephen P.] Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA.
[Hunger, Stephen P.] Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA.
RP Mullighan, CG (reprint author), St Jude Childrens Res Hosp, Dept Pathol, 262 Danny Thomas Pl,MS 342, Memphis, TN 38105 USA.; Mullighan, CG (reprint author), St Jude Childrens Res Hosp, Hematol Malignancies Program, 262 Danny Thomas Pl,MS 342, Memphis, TN 38105 USA.
EM charles.mullighan@stjude.org
RI LI, YONGJIN/E-1688-2011; Marra, Marco/B-5987-2008;
OI McCastlain, Kelly/0000-0001-7868-3049
FU American Lebanese Syrian Associated Charities of St. Jude Children's
Research Hospital; Stand Up to Cancer Innovative Research Grant; St.
Baldrick's Consortium Award; Leukemia and Lymphoma Society Specialized
Center of Research grant; Lady Tata Memorial Trust Award; Leukemia and
Lymphoma Society; Alex's Lemonade Stand Foundation; National Cancer
Institute [CA21765, U01 CA157937, U24 CA114737]; NCI [HHSN261200800001E,
U10 CA180820, CA180827, U10 CA180861, U24 CA196171, CA145707, U10
CA98543, U10 CA98413, U24 CA114766]; National Cancer Institute, National
Institutes of Health [HHSN261200800001E]; St. Baldrick's Foundation
Scholar Award
FX We thank Haitao Ji for providing BCL9 inhibitors. This work was
supported in part by the American Lebanese Syrian Associated Charities
of St. Jude Children's Research Hospital; by a Stand Up to Cancer
Innovative Research Grant and St. Baldrick's Foundation Scholar Award
(to C.G.M.); by a St. Baldrick's Consortium Award (S.P.H.), by a
Leukemia and Lymphoma Society Specialized Center of Research grant
(S.P.H. and C.G.M.), by a Lady Tata Memorial Trust Award (I. I.), by a
Leukemia and Lymphoma Society Special Fellow Award and Alex's Lemonade
Stand Foundation Young Investigator Awards (K.R.), by an Alex's Lemonade
Stand Foundation Award (M.L.) and by National Cancer Institute Grants
CA21765 (St Jude Cancer Center Support Grant), U01 CA157937 (C.L.W. and
S.P.H.), U24 CA114737 (to Dr Gastier-Foster), NCI Contract
HHSN261200800001E (to Dr Gastier-Foster), U10 CA180820 (ECOG-ACRIN
Operations) and CA180827 (E.P.); U10 CA180861 (C.D.B. and G.M.); U24
CA196171 (The Alliance NCTN Biorepository and Biospecimen Resource);
CA145707 (C.L.W. and C.G.M.); and grants to the COG: U10 CA98543
(Chair's grant and supplement to support the COG ALL TARGET project),
U10 CA98413 (Statistical Center) and U24 CA114766 (Specimen Banking).
This project has been funded in whole or in part with Federal funds from
the National Cancer Institute, National Institutes of Health, under
Contract Number HHSN261200800001E. The content of this publication does
not necessarily reflect the views or policies of the Department of
Health and Human Services, nor does mention of trade names, commercial
products or organizations imply endorsement by the U.S. Government. We
thank the staff of the Biorepository, the Hartwell Centre for
Bioinformatics and Biotechnology, the Flow Cytometry and Cell Sorting
Core Facility and the Cytogenetics Core Facility of St Jude Children's
Research Hospital.
NR 45
TC 1
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U1 4
U2 4
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2041-1723
J9 NAT COMMUN
JI Nat. Commun.
PD NOV 8
PY 2016
VL 7
AR 13331
DI 10.1038/ncomms13331
PG 10
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA EB3IX
UT WOS:000387258700001
PM 27824051
ER
PT J
AU McIntyre, MK
Peacock, TJ
Akers, KS
Burmeister, DM
AF McIntyre, Matthew K.
Peacock, Trent J.
Akers, Kevin S.
Burmeister, David M.
TI Initial Characterization of the Pig Skin Bacteriome and Its Effect on In
Vitro Models of Wound Healing
SO PLOS ONE
LA English
DT Article
AB Elucidating the roles and composition of the human skin microbiome has revealed a delicate interplay between resident microbes and wound healing. Evolutionarily speaking, normal cutaneous flora likely has been selected for because it potentiates or, at minimum, does not impede wound healing. While pigs are the gold standard model for wound healing studies, the porcine skin microbiome has not been studied in detail. Herein, we performed 16S rDNA sequencing to characterize the pig skin bacteriome at several anatomical locations. Additionally, we used bacterial conditioned-media with in vitro techniques to examine the paracrine effects of bacterial-derived proteins on human keratinocytes (NHEK) and fibroblasts (NHDF). We found that at the phyla level, the pig skin bacteriome is similar to that of humans and largely consists of Firmicutes (55.6%), Bacteroidetes (20.8%), Actinobacteria (13.3%), and Proteobacteria (5.1%) however species-level differences between anatomical locations exist. Studies of bacterial supernatant revealed location-dependent effects on NHDF migration and NHEK apoptosis and growth factor release. These results expand the limited knowledge of the cutaneous bacteriome of healthy swine, and suggest that naturally occurring bacterial flora affects wound healing differentially depending on anatomical location. Ultimately, the pig might be considered the best surrogate for not only wound healing studies but also the cutaneous microbiome. This would not only facilitate investigations into the microbiome's role in recovery from injury, but also provide microbial targets for enhancing or accelerating wound healing.
C1 [McIntyre, Matthew K.; Burmeister, David M.] US Army, Damage Control Resuscitat, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
[Peacock, Trent J.] US Army, Dent Trauma Res Detachment, Inst Surg Res, Ft Sam Houston, TX USA.
[Akers, Kevin S.] US Army, Extrem Trauma & Regenerat Med, Inst Surg Res, Ft Sam Houston, TX USA.
RP Burmeister, DM (reprint author), US Army, Damage Control Resuscitat, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
EM David.m.Burmeister3.civ@mail.mil
FU Oak Ridge Institute for Science and Education; US Army Medical Research
and Materiel Command
FX This study was supported by the Oak Ridge Institute for Science and
Education and the US Army Medical Research and Materiel Command. The
funders had no role in study design, data collection and analysis,
decision to publish, or preparation of the manuscript.
NR 50
TC 0
Z9 0
U1 4
U2 4
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD NOV 8
PY 2016
VL 11
IS 11
AR e0166176
DI 10.1371/journal.pone.0166176
PG 18
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA EB8BE
UT WOS:000387615200066
PM 27824921
ER
PT J
AU Blanquart, F
Grabowski, MK
Herbeck, J
Nalugoda, F
Serwadda, D
Eller, MA
Robb, ML
Gray, R
Kigozi, G
Laeyendecker, O
Lythgoe, KA
Nakigozi, G
Quinn, TC
Reynolds, SJ
Wawer, MJ
Fraser, C
AF Blanquart, Francois
Grabowski, Mary Kate
Herbeck, Joshua
Nalugoda, Fred
Serwadda, David
Eller, Michael A.
Robb, Merlin L.
Gray, Ronald
Kigozi, Godfrey
Laeyendecker, Oliver
Lythgoe, Katrina A.
Nakigozi, Gertrude
Quinn, Thomas C.
Reynolds, Steven J.
Wawer, Maria J.
Fraser, Christophe
TI A transmission-virulence evolutionary trade-off explains attenuation of
HIV-1 in Uganda
SO ELIFE
LA English
DT Article
ID GENITAL ULCER DISEASE; SIMPLEX-VIRUS TYPE-2; VIRAL LOAD; PROGNOSTIC
MARKERS; PROSPECTIVE COHORT; SET-POINT; PROGRESSION; POPULATION;
INFECTION; RAKAI
AB Evolutionary theory hypothesizes that intermediate virulence maximizes pathogen fitness as a result of a trade-off between virulence and transmission, but empirical evidence remains scarce. We bridge this gap using data from a large and long-standing HIV-1 prospective cohort, in Uganda. We use an epidemiological-evolutionary model parameterised with this data to derive evolutionary predictions based on analysis and detailed individual-based simulations. We robustly predict stabilising selection towards a low level of virulence, and rapid attenuation of the virus. Accordingly, set-point viral load, the most common measure of virulence, has declined in the last 20 years. Our model also predicts that subtype A is slowly outcompeting subtype D, with both subtypes becoming less virulent, as observed in the data. Reduction of set-point viral loads should have resulted in a 20% reduction in incidence, and a three years extension of untreated asymptomatic infection, increasing opportunities for timely treatment of infected individuals.
C1 [Blanquart, Francois; Lythgoe, Katrina A.; Fraser, Christophe] Imperial Coll London, MRC Ctr Outbreak Anal & Modelling, London, England.
[Blanquart, Francois; Lythgoe, Katrina A.; Fraser, Christophe] Imperial Coll London, Dept Infect Dis Epidemiol, London, England.
[Blanquart, Francois; Lythgoe, Katrina A.; Fraser, Christophe] Imperial Coll London, Sch Publ Hlth, London, England.
[Grabowski, Mary Kate; Gray, Ronald; Wawer, Maria J.] Johns Hopkins Univ, Dept Epidemiol, Baltimore, MD USA.
[Grabowski, Mary Kate; Gray, Ronald; Wawer, Maria J.] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Baltimore, MD USA.
[Herbeck, Joshua] Univ Washington, Int Clin Res Ctr, Seattle, WA 98195 USA.
[Herbeck, Joshua] Univ Washington, Dept Global Hlth, Seattle, WA 98195 USA.
[Nalugoda, Fred; Serwadda, David; Gray, Ronald; Kigozi, Godfrey; Nakigozi, Gertrude] Rakai Hlth Sci Program, Entebbe, Uganda.
[Serwadda, David] Makerere Univ, Sch Publ Hlth, Kampala, Uganda.
[Eller, Michael A.; Robb, Merlin L.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA.
[Eller, Michael A.; Robb, Merlin L.] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA.
[Laeyendecker, Oliver; Quinn, Thomas C.; Reynolds, Steven J.] NIAID, Immunoregulat Lab, NIH, Bldg 10, Bethesda, MD 20892 USA.
[Laeyendecker, Oliver; Quinn, Thomas C.; Reynolds, Steven J.] NIAID, Div Intramural Res, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA.
[Lythgoe, Katrina A.] Univ Oxford, Dept Zool, Oxford, England.
[Fraser, Christophe] Univ Oxford, Big Data Inst, Nuffield Dept Med, Li Ka Shing Ctr Hlth Informat & Discovery, Oxford, England.
RP Blanquart, F (reprint author), Imperial Coll London, MRC Ctr Outbreak Anal & Modelling, London, England.; Blanquart, F (reprint author), Imperial Coll London, Dept Infect Dis Epidemiol, London, England.; Blanquart, F (reprint author), Imperial Coll London, Sch Publ Hlth, London, England.
EM f.blanguart@imperial.ac.uk
OI Fraser, Christophe/0000-0003-2399-9657
FU European Commission [657768]; National Institute of Allergy and
Infectious Diseases [R01 AI29314, R01 A134826, U01 AI11171-01-02];
National Institute of Child Health and Development [5P30 HD 06268]; John
E. Fogarty Foundation for Persons with Intellectual and Developmental
Disabilities [5D43TW00010]; John Snow Inc. [5024-30]; Pfizer [5024-30];
Rockefeller Foundation; World Bank Group; National Institutes of Health
[P30AI027757, R01AI108490]; U.S. Department of Defense
[W81XWH-07-2-0067]; Henry M. Jackson Foundation [W81XWH-07-2-0067];
European Research Council [PBDR-339251]
FX European Commission Intra European Fellowship 657768 Francois Blanquart;
National Institute of Allergy and Infectious Diseases R01 AI29314 Mary
Kate Grabowski Fred Nalugoda David Serwadda Michael A Eller Merlin L
Robb Ronald Gray Godfrey Kigozi Oliver Laeyendecker Gertrude Nakigozi
Thomas C Quinn Steven J Reynolds Maria J Wawer; National Institute of
Child Health and Development 5P30 HD 06268 Mary Kate Grabowski Fred
Nalugoda David Serwadda Michael A Eller Merlin L Robb Ronald Gray
Godfrey Kigozi Oliver Laeyendecker Gertrude Nakigozi Thomas C Quinn
Steven J Reynolds Maria J Wawer; John E. Fogarty Foundation for Persons
with Intellectual and Developmental Disabilities 5D43TW00010 Mary Kate
Grabowski Fred Nalugoda David Serwadda Michael A Eller Merlin L Robb
Ronald Gray Godfrey Kigozi Oliver Laeyendecker Gertrude Nakigozi Thomas
C Quinn Steven J Reynolds Maria J Wawer; John Snow Inc. 5024-30 Mary
Kate Grabowski Fred Nalugoda David Serwadda Michael A Eller Merlin L
Robb Ronald Gray Godfrey Kigozi Oliver Laeyendecker Gertrude Nakigozi
Thomas C Quinn Steven J Reynolds Maria J Wawer; Pfizer 5024-30 Mary Kate
Grabowski Fred Nalugoda David Serwadda Michael A Eller Merlin L Robb
Ronald Gray Godfrey Kigozi Oliver Laeyendecker Gertrude Nakigozi Thomas
C Quinn Steven J Reynolds Maria J Wawer; Rockefeller Foundation Mary
Kate Grabowski Fred Nalugoda David Serwadda Michael A Eller Merlin L
Robb Ronald Gray Godfrey Kigozi Oliver Laeyendecker Gertrude Nakigozi
Thomas C Quinn Steven J Reynolds Maria J Wawer; World Bank Group Mary
Kate Grabowski Fred Nalugoda David Serwadda Michael A Eller Merlin L
Robb Ronald Gray Godfrey Kigozi Oliver Laeyendecker Gertrude Nakigozi
Thomas C Quinn Steven J Reynolds Maria J Wawer; National Institute of
Allergy and Infectious Diseases R01 A134826 Mary Kate Grabowski Fred
Nalugoda David Serwadda Michael A Eller Merlin L Robb Ronald Gray
Godfrey Kigozi Oliver Laeyendecker Gertrude Nakigozi Thomas C Quinn
Steven J Reynolds Maria J Wawer; National Institute of Allergy and
Infectious Diseases U01 AI11171-01-02 Mary Kate Grabowski Fred Nalugoda
David Serwadda Michael A Eller Merlin L Robb Ronald Gray Godfrey Kigozi
Oliver Laeyendecker Gertrude Nakigozi Thomas C Quinn Steven J Reynolds
Maria J Wawer; National Institutes of Health P30AI027757 Joshua Herbeck;
National Institutes of Health R01AI108490 Joshua Herbeck; U.S.
Department of Defense W81XWH-07-2-0067 Michael A Eller Merlin L Robb;
Henry M. Jackson Foundation W81XWH-07-2-0067 Michael A Eller Merlin L
Robb; European Research Council PBDR-339251 Christophe Fraser
NR 67
TC 1
Z9 1
U1 2
U2 2
PU ELIFE SCIENCES PUBLICATIONS LTD
PI CAMBRIDGE
PA SHERATON HOUSE, CASTLE PARK, CAMBRIDGE, CB3 0AX, ENGLAND
SN 2050-084X
J9 ELIFE
JI eLife
PD NOV 5
PY 2016
VL 5
AR e20492
DI 10.7554/eLife.20492
PG 31
WC Biology
SC Life Sciences & Biomedicine - Other Topics
GA ED2NJ
UT WOS:000388683400001
ER
PT J
AU Krishnamurthy, M
Moore, RT
Rajamani, S
Panchal, RG
AF Krishnamurthy, Malathy
Moore, Richard T.
Rajamani, Sathish
Panchal, Rekha G.
TI Bacterial genome engineering and synthetic biology: combating pathogens
SO BMC MICROBIOLOGY
LA English
DT Review
DE Synthetic Biology (SB); Multidrug resistant (MDR) pathogens; Antibiotic
resistance; Genome engineering; Antibacterial; Quorum sensing; Gene
circuits; Pathogenesis; Recombineering; Targetron
ID SEQUENCE-SPECIFIC ANTIMICROBIALS; GROUP-II INTRONS; ESCHERICHIA-COLI;
PSEUDOMONAS-AERUGINOSA; ESSENTIAL GENES; COMBINATORIAL BIOSYNTHESIS;
STAPHYLOCOCCUS-AUREUS; RECOMBINATION; IDENTIFICATION; DAPTOMYCIN
AB Background: The emergence and prevalence of multidrug resistant (MDR) pathogenic bacteria poses a serious threat to human and animal health globally. Nosocomial infections and common ailments such as pneumonia, wound, urinary tract, and bloodstream infections are becoming more challenging to treat due to the rapid spread of MDR pathogenic bacteria. According to recent reports by the World Health Organization (WHO) and Centers for Disease Control and Prevention (CDC), there is an unprecedented increase in the occurrence of MDR infections worldwide. The rise in these infections has generated an economic strain worldwide, prompting the WHO to endorse a global action plan to improve awareness and understanding of antimicrobial resistance. This health crisis necessitates an immediate action to target the underlying mechanisms of drug resistance in bacteria.
Research: The advent of new bacterial genome engineering and synthetic biology (SB) tools is providing promising diagnostic and treatment plans to monitor and treat widespread recalcitrant bacterial infections. Key advances in genetic engineering approaches can successfully aid in targeting and editing pathogenic bacterial genomes for understanding and mitigating drug resistance mechanisms. In this review, we discuss the application of specific genome engineering and SB methods such as recombineering, clustered regularly interspaced short palindromic repeats (CRISPR), and bacterial cell-cell signaling mechanisms for pathogen targeting. The utility of these tools in developing antibacterial strategies such as novel antibiotic production, phage therapy, diagnostics and vaccine production to name a few, are also highlighted.
Conclusions: The prevalent use of antibiotics and the spread of MDR bacteria raise the prospect of a post-antibiotic era, which underscores the need for developing novel therapeutics to target MDR pathogens. The development of enabling SB technologies offers promising solutions to deliver safe and effective antibacterial therapies.
C1 [Krishnamurthy, Malathy; Moore, Richard T.; Rajamani, Sathish; Panchal, Rekha G.] US Army, Med Res Inst Infect Dis, Dept Target Discovery & Expt Microbiol, Div Mol & Translat Sci, Frederick, MD 21702 USA.
RP Panchal, RG (reprint author), US Army, Med Res Inst Infect Dis, Dept Target Discovery & Expt Microbiol, Div Mol & Translat Sci, Frederick, MD 21702 USA.
EM rekha.g.panchal.civ@mail.mil
FU Department of Defense Chemical Biological Defense Program through the
Defense Threat Reduction Agency (DTRA) under United States Army Medical
Research Institute of Infectious Diseases (USAMRIID) [13267645]; Oak
Ridge Institute for Science and Education (ORISE) Fellowship; USAMRIID
FX This work was supported by the Department of Defense Chemical Biological
Defense Program through the Defense Threat Reduction Agency (DTRA) under
United States Army Medical Research Institute of Infectious Diseases
(USAMRIID) project number 13267645. Opinions, interpretations,
conclusions, and recommendations are those of the authors and are not
necessarily endorsed by the U.S. Army. This manuscript was written when
MK held an NRC Research Associateship award at USAMRIID. RTM was
supported by Oak Ridge Institute for Science and Education (ORISE)
Fellowship.
NR 82
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Z9 1
U1 48
U2 48
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2180
J9 BMC MICROBIOL
JI BMC Microbiol.
PD NOV 4
PY 2016
VL 16
AR 258
DI 10.1186/s12866-016-0876-3
PG 11
WC Microbiology
SC Microbiology
GA EB1CE
UT WOS:000387083200003
PM 27814687
ER
PT J
AU Konongoi, L
Ofula, V
Nyunja, A
Owaka, S
Koka, H
Makio, A
Koskei, E
Eyase, F
Langat, D
Schoepp, RJ
Rossi, CA
Njeru, I
Coldren, R
Sang, R
AF Konongoi, Limbaso
Ofula, Victor
Nyunja, Albert
Owaka, Samuel
Koka, Hellen
Makio, Albina
Koskei, Edith
Eyase, Fredrick
Langat, Daniel
Schoepp, Randal J.
Rossi, Cynthia Ann
Njeru, Ian
Coldren, Rodney
Sang, Rosemary
TI Detection of dengue virus serotypes 1, 2 and 3 in selected regions of
Kenya: 2011-2014
SO VIROLOGY JOURNAL
LA English
DT Article
DE Dengue; Serotypes 1, 2 and 3; Kenya
ID HEMORRHAGIC-FEVER; CHIKUNGUNYA VIRUS; FEBRILE PATIENTS; YELLOW-FEVER;
INFECTIONS; AFRICA; INDIA; TRANSMISSION; TRAVELERS; SOMALIA
AB Background: Dengue fever, a mosquito-borne disease, is associated with illness of varying severity in countries in the tropics and sub tropics. Dengue cases continue to be detected more frequently and its geographic range continues to expand. We report the largest documented laboratory confirmed circulation of dengue virus in parts of Kenya since 1982.
Methods: From September 2011 to December 2014, 868 samples from febrile patients were received from hospitals in Nairobi, northern and coastal Kenya. The immunoglobulin M enzyme linked immunosorbent assay (IgM ELISA) was used to test for the presence of IgM antibodies against dengue, yellow fever, West Nile and Zika. Reverse transcription polymerase chain reaction (RT-PCR) utilizing flavivirus family, yellow fever, West Nile, consensus and sero type dengue primers were used to detect acute arbovirus infections and determine the infecting serotypes. Representative samples of PCR positive samples for each of the three dengue serotypes detected were sequenced to confirm circulation of the various dengue serotypes.
Results: Forty percent (345/ 868) of the samples tested positive for dengue by either IgM ELISA (14.6 %) or by RT-PCR (25.1 %). Three dengue serotypes 1-3 (DENV1-3) were detected by serotype specific RT-PCR and sequencing with their numbers varying from year to year and by region. The overall predominant serotype detected from 2011-2014 was DENV1 accounting for 44 % (96/218) of all the serotypes detected, followed by DENV2 accounting for 38.5 % (84/218) and then DENV3 which accounted for 17.4 % (38/218). Yellow fever, West Nile and Zika was not detected in any of the samples tested.
Conclusion: From 2011-2014 serotypes 1, 2 and 3 were detected in the Northern and Coastal parts of Kenya. This confirmed the occurrence of cases and active circulation of dengue in parts of Kenya. These results have documented three circulating serotypes and highlight the need for the establishment of active dengue surveillance to continuously detect cases, circulating serotypes, and determine dengue fever disease burden in the country and region.
C1 [Konongoi, Limbaso; Sang, Rosemary] Kenya Govt Med Res Ctr, POB 54628-00200, Nairobi, Kenya.
[Konongoi, Limbaso; Ofula, Victor; Nyunja, Albert; Owaka, Samuel; Koka, Hellen; Makio, Albina; Koskei, Edith; Eyase, Fredrick; Coldren, Rodney; Sang, Rosemary] US Army, Med Res Directorate, POB 606, Nairobi, Kenya.
[Langat, Daniel; Njeru, Ian] Kenya Minist Hlth, Div Dis Surveillance & Response, POB 20781-00202, Nairobi, Kenya.
[Schoepp, Randal J.; Rossi, Cynthia Ann] US Army, Med Res Inst Infect Dis, 1425 Porter St, Frederick, MD 21702 USA.
RP Konongoi, L (reprint author), Kenya Govt Med Res Ctr, POB 54628-00200, Nairobi, Kenya.; Konongoi, L (reprint author), US Army, Med Res Directorate, POB 606, Nairobi, Kenya.
EM Limbaso@gmail.com
NR 49
TC 0
Z9 0
U1 14
U2 14
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1743-422X
J9 VIROL J
JI Virol. J.
PD NOV 4
PY 2016
VL 13
AR 182
DI 10.1186/s12985-016-0641-0
PG 11
WC Virology
SC Virology
GA EB1CT
UT WOS:000387084700002
PM 27814732
ER
PT J
AU Scher, JA
Elward, JM
Chakraborty, A
AF Scher, Jeremy A.
Elward, Jennifer M.
Chakraborty, Arindam
TI Shape Matters: Effect of 1D, 2D, and 3D Isovolumetric Quantum
Confinement in Semiconductor Nanoparticies
SO JOURNAL OF PHYSICAL CHEMISTRY C
LA English
DT Article
ID RESONANCE ENERGY-TRANSFER; MULTIPLE EXCITON GENERATION; CARRIER
MULTIPLICATION YIELDS; AUGER RECOMBINATION; ELECTRON INJECTION;
AB-INITIO; CHARGE SEPARATION; NANOCRYSTAL SHAPE; MAGNETIC-FIELDS; TIO2
SURFACE
AB Semiconductor nanoparticles (NPs) are a class of nanoscopic materials with highly tunable optical and electronic properties. The electronic density of states of these NPs depends strongly on both shape and size and has allowed semiconductor NPs to be tailored for applications in various fields including photovoltaics, solid-state lighting, and biological labeling. This work presents investigation of the effect of shape on excitonic properties of electronically excited NPs. Specifically, this work focuses on isovolumetric NPs and addresses the question of how optical properties of NPs are impacted by isovolumetic deformation of NP shapes. The effects of three shapes, representing 1D, 2D, and 3D quantum confinement, for three sizes and four semiconductor materials (CdSe, CdS, CdTe, and PbS) were studied. The electronic excitation in these NPs was described using electron-hole (eh) quasiparticle representation, and exciton binding energies, eh joint probabilities, and eh-separation distances were calculated using the eh explicitly correlated Hartree-Fock method. The calculations demonstrated that increased. anisotropy in the confinement potential resulted in decreased exciton binding energy in the NPs. Within a specific volume, it was found that nanorods exhibited lower exciton binding energies than did nanodisks and that nanodisks exhibited lower exciton binding energies than nanospheres of identical volume. In contrast, the trend for eh-joint probability was found to be opposite that of exciton binding energies. These results demonstrate that a relatively small change in NP structure can result in a substantial change in the excitonic properties of these nanomaterials.
C1 [Scher, Jeremy A.; Chakraborty, Arindam] Syracuse Univ, Dept Chem, Syracuse, NY 13244 USA.
[Elward, Jennifer M.] Army Res Lab, Aberdeen, MD 21005 USA.
RP Chakraborty, A (reprint author), Syracuse Univ, Dept Chem, Syracuse, NY 13244 USA.
EM archakra@syr.edu
FU National Science Foundation [CHE-1349892, ACI-1053575]; Syracuse
University
FX This material is based upon work supported by the National Science
Foundation under Grant No. CHE-1349892. This work used the Extreme
Science and Engineering Discovery Environment (XSEDE), which is
supported by National Science Foundation Grant No. ACI-1053575. We are
also grateful to Syracuse University for additional computational and
financial support.
NR 108
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U1 17
U2 17
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1932-7447
J9 J PHYS CHEM C
JI J. Phys. Chem. C
PD NOV 3
PY 2016
VL 120
IS 43
BP 24999
EP 25009
DI 10.1021/acs.jpcc.6b06728
PG 11
WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science,
Multidisciplinary
SC Chemistry; Science & Technology - Other Topics; Materials Science
GA EB2NF
UT WOS:000387198400056
ER
PT J
AU Hoge, CW
Ivany, CG
Schoenbaum, M
AF Hoge, Charles W.
Ivany, Christopher G.
Schoenbaum, Michael
TI Death by suicide in US military during the Afghanistan and Iraq wars
SO LANCET PSYCHIATRY
LA English
DT Editorial Material
ID SERVICE MEMBERS; MENTAL-HEALTH; RISK; VETERANS; ARMY
C1 [Hoge, Charles W.] Walter Reed Army Inst Res, Ctr Psychiat & Neurosci, Silver Spring, MD 20910 USA.
[Ivany, Christopher G.] Off Army Surgeon Gen, Falls Church, VA USA.
[Schoenbaum, Michael] NIMH, Div Serv & Intervent Res, Bethesda, MD 20892 USA.
RP Hoge, CW (reprint author), Walter Reed Army Inst Res, Ctr Psychiat & Neurosci, Silver Spring, MD 20910 USA.
EM charles.w.hoge.civ@mail.mil
NR 12
TC 0
Z9 0
U1 1
U2 1
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 2215-0374
J9 LANCET PSYCHIAT
JI Lancet Psychiatry
PD NOV
PY 2016
VL 3
IS 11
BP 1001
EP 1003
DI 10.1016/S2215-0366(16)30305-4
PG 4
WC Psychiatry
SC Psychiatry
GA EN9UL
UT WOS:000396345000008
PM 27697515
ER
PT J
AU Rabago, CA
Clouser, M
Dearth, CL
Farrokhi, S
Galarneau, MR
Highsmith, MJ
Wilken, JM
Wyatt, MP
Hill, OT
AF Rabago, Christopher A.
Clouser, Mary
Dearth, Christopher L.
Farrokhi, Shawn
Galarneau, Michael R.
Highsmith, M. Jason
Wilken, Jason M.
Wyatt, Marilynn P.
Hill, Owen T.
TI The Extremity Trauma and Amputation Center of Excellence: Overview of
the Research and Surveillance Division
SO MILITARY MEDICINE
LA English
DT Article
ID LOWER-LIMB LOSS; ACTIVITY MOBILITY PREDICTOR; OPERATION IRAQI FREEDOM;
ANKLE-FOOT PROSTHESES; TRANSTIBIAL AMPUTATION; DESTABILIZING
ENVIRONMENTS; MALE SERVICEMEMBERS; C-LEG; TRANSFEMORAL AMPUTATION;
DYNAMIC STABILITY
AB Congress authorized creation of the Extremity Trauma and Amputation Center of Excellence (EACE) as part of the 2009 National Defense Authorization Act. The legislation mandated the Department of Defense (DoD) and Department of Veterans Affairs (VA) to implement a comprehensive plan and strategy for the mitigation, treatment, and rehabilitation of traumatic extremity injuries and amputation. The EACE also was tasked with conducting clinically relevant research, fostering collaborations, and building partnerships across multidisciplinary international, federal, and academic networks to optimize the quality of life of service members and veterans who have sustained extremity trauma or amputations. To fulfill themandate to conduct research, the EACE developed a Research and Surveillance Division that complements and collaborates with outstanding DoD, VA, and academic research programs across the globe. The EACE researchers have efforts in four key research focus areas relevant to extremity trauma and amputation: (1) Novel Rehabilitation Interventions, (2) Advanced Prosthetic and Orthotic Technologies, (3) Epidemiology and Surveillance, and (4) Medical and Surgical Innovations. This overview describes the EACE efforts to innovate, discover, and translate knowledge gleaned from collaborative research partnerships into clinical practice and policy.
C1 [Rabago, Christopher A.; Clouser, Mary; Dearth, Christopher L.; Farrokhi, Shawn; Galarneau, Michael R.; Highsmith, M. Jason; Wilken, Jason M.; Hill, Owen T.] Extrem Trauma & Amputat Ctr Excellence, 2748 Worth Rd,Suite 29, Joint Base San Antonio F, TX 78234 USA.
[Rabago, Christopher A.; Wilken, Jason M.; Hill, Owen T.] Brooke Army Med Ctr, Dept Rehabil Med, Ctr Intrepid, 3551 Roger Brooke Dr, Joint Base San Antonio F, TX 78234 USA.
[Clouser, Mary; Galarneau, Michael R.] Naval Hlth Res Ctr, 140 Sylvester Rd, San Diego, CA 92106 USA.
[Dearth, Christopher L.] Walter Reed Natl Mil Med Ctr, Dept Rehabil, Res & Dev Sect, 8901 Rockville Pike, Bethesda, MD 20889 USA.
[Farrokhi, Shawn; Wyatt, Marilynn P.] Naval Med Ctr San Diego, Dept Phys & Occupat Therapy, 34800 Bob Wilson Dr, San Diego, CA 92134 USA.
[Highsmith, M. Jason] James A Haley Vet Adm Hosp, Ctr Innovat Disabil & Rehabil Res, 8900 Grand Oak Circle 151R, Tampa, FL 33637 USA.
[Highsmith, M. Jason] Univ S Florida, Morsani Coll Med, Sch Phys Therapy & Rehabil Sci, 3515 E Fletcher Ave, Tampa, FL 33612 USA.
[Highsmith, M. Jason] US Dept Vet Affairs, Rehabil Serv, 810 Vermont Ave NW, Washington, DC 20420 USA.
[Highsmith, M. Jason] US Dept Vet Affairs, Prosthet Serv, 810 Vermont Ave NW, Washington, DC 20420 USA.
RP Rabago, CA (reprint author), Extrem Trauma & Amputat Ctr Excellence, 2748 Worth Rd,Suite 29, Joint Base San Antonio F, TX 78234 USA.; Rabago, CA (reprint author), Brooke Army Med Ctr, Dept Rehabil Med, Ctr Intrepid, 3551 Roger Brooke Dr, Joint Base San Antonio F, TX 78234 USA.
OI Rabago, Christopher/0000-0002-4484-0613
NR 74
TC 0
Z9 0
U1 1
U2 1
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD NOV
PY 2016
VL 181
SU 4
SI SI
BP 3
EP 12
DI 10.7205/MILMED-D-16-00279
PG 10
WC Medicine, General & Internal
SC General & Internal Medicine
GA EL3EA
UT WOS:000394501200002
PM 27849455
ER
PT J
AU Stanhope, SJ
Wilken, JM
Pruziner, AL
Dearth, CL
Wyatt, M
Ziemke, GW
Strickland, R
Milbourne, SA
Kaufman, KR
AF Stanhope, Steven J.
Wilken, Jason M.
Pruziner, Alison L.
Dearth, Christopher L.
Wyatt, Marilynn
Ziemke, Gregg W.
Strickland, Rachel
Milbourne, Suzanne A.
Kaufman, Kenton R.
TI The Bridging Advanced Developments for Exceptional Rehabilitation
(BADER) Consortium: Reaching in Partnership for Optimal Orthopaedic
Rehabilitation Outcomes
SO MILITARY MEDICINE
LA English
DT Article
AB The Bridging Advanced Developments for Exceptional Rehabilitation (BADER) Consortium began in September 2011 as a cooperative agreement with the Department of Defense (DoD) Congressionally Directed Medical Research Programs Peer Reviewed Orthopaedic Research Program. A partnership was formed with DoD Military Treatment Facilities (MTFs), U. S. Department of Veterans Affairs (VA) Centers, the National Institutes of Health (NIH), academia, and industry to rapidly conduct innovative, high-impact, and sustainable clinically relevant research. The BADER Consortium has a unique research capacity-building focus that creates infrastructures and strategically connects and supports research teams to conduct multiteam research initiatives primarily led by MTF and VA investigators.
BADER relies on strong partnerships with these agencies to strengthen and support orthopaedic rehabilitation research. Its focus is on the rapid forming and execution of projects focused on obtaining optimal functional outcomes for patients with limb loss and limb injuries. The Consortium is based on an NIH research capacity-building model that comprises essential research support components that are anchored by a set of BADER-funded and initiative-launching studies. Through a partnership with the DoD/VA Extremity Trauma and Amputation Center of Excellence, the BADER Consortium's research initiative-launching program has directly supported the identification and establishment of eight BADER-funded clinical studies. BADER's Clinical Research Core (CRC) staff, who are embedded within each of the MTFs, have supported an additional 37 non-BADER Consortium-funded projects. Additional key research support infrastructures that expedite the process for conducting multisite clinical trials include an omnibus Cooperative Research and Development Agreement and the NIH Clinical Trials Database. A 2015 Defense Health Board report highlighted the Consortium's vital role, stating the research capabilities of the DoD Advanced Rehabilitation Centers are significantly enhanced and facilitated by the BADER Consortium.
C1 [Stanhope, Steven J.; Strickland, Rachel] Univ Delaware, 540 S Coll Ave, Newark, DE 19713 USA.
[Wilken, Jason M.] Brooke Army Med Ctr, Dept Rehabil Med, Ctr Intrepid, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
[Wilken, Jason M.; Pruziner, Alison L.; Dearth, Christopher L.] Extrem Trauma & Amputat Ctr Excellence, 2748 Worth Rd,Suite 29, Ft Sam Houston, TX 78234 USA.
[Pruziner, Alison L.; Dearth, Christopher L.] Walter Reed Natl Mil Med Ctr, Res & Dev Sect, Dept Rehabil, 8901 Rockville Pike, Bethesda, MD 20889 USA.
[Wyatt, Marilynn] Naval Med Ctr San Diego, 34800 Bob Wilson Dr, San Diego, CA 92134 USA.
[Ziemke, Gregg W.] Naval Med Ctr Portsmouth, 620 John Paul Jones Circle, Portsmouth, VA 23708 USA.
[Milbourne, Suzanne A.] Univ Delaware, Ctr Disabil Studies, 540 Wyoming Rd, Newark, DE 19716 USA.
[Kaufman, Kenton R.] Mayo Clin, Biomed Engn, 200 First St SW, Rochester, MN 55905 USA.
RP Stanhope, SJ (reprint author), Univ Delaware, 540 S Coll Ave, Newark, DE 19713 USA.
FU Congressionally Directed Medical Research Program (CDMRP)
[W81XWH-11-2-0222]; Peer Reviewed Orthopaedic Research Program (PRORP)
[W81XWH-11-2-0222]; NIH-NIGMS [P20 GM103446]; NIH-NICHD; University of
Delaware, College of Health Sciences
FX Support for the BADER Consortium was provided by the Congressionally
Directed Medical Research Program (CDMRP), Peer Reviewed Orthopaedic
Research Program (PRORP) via award number W81XWH-11-2-0222; the
NIH-NIGMS (P20 GM103446); the NIH-NICHD through a collaboration
agreement; and the University of Delaware, College of Health Sciences.
Finally, none of this work would be possible without the courage and
drive of wounded warriors whose desire to continue serving and actively
engage life is beyond inspirational.
NR 9
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U1 0
U2 0
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD NOV
PY 2016
VL 181
SU 4
SI SI
BP 13
EP 19
DI 10.7205/MILMED-D-15-00501
PG 7
WC Medicine, General & Internal
SC General & Internal Medicine
GA EL3EA
UT WOS:000394501200003
PM 27849456
ER
PT J
AU Isaacson, BM
Hendershot, BD
Messinger, SD
Wilken, JM
Rabago, CA
Esposito, ER
Wolf, E
Pruziner, AL
Dearth, CL
Wyatt, M
Cohen, SP
Tsao, JW
Pasquina, PF
AF Isaacson, Brad M.
Hendershot, Brad D.
Messinger, Seth D.
Wilken, Jason M.
Rabago, Christopher A.
Esposito, Elizabeth Russell
Wolf, Erik
Pruziner, Alison L.
Dearth, Christopher L.
Wyatt, Marilynn
Cohen, Steven P.
Tsao, Jack W.
Pasquina, Paul F.
TI The Center for Rehabilitation Sciences Research: Advancing the
Rehabilitative Care for Service Members With Complex Trauma
SO MILITARY MEDICINE
LA English
DT Article
ID EPIDURAL STEROID INJECTIONS; HETEROTOPIC OSSIFICATION; PHANTOM LIMBS;
NECK PAIN; PREVALENCE; AMPUTATION; BONE; MULTICENTER; CONSCRIPTS;
DISORDERS
AB The Center for Rehabilitation Sciences Research (CRSR) was established to advance the rehabilitative care for service members with combat-related injuries, particularly those with orthopedic, cognitive, and neurological complications. The center supports comprehensive research projects to optimize treatment strategies and promote the successful return to duty and community reintegration of injured service members. The center also provides a unique platform for fostering innovative research and incorporating clinical/technical advances in the rehabilitative care for service members. CRSR is composed of four research focus areas: (1) identifying barriers to successful rehabilitation and reintegration, (2) improving pain management strategies to promote full participation in rehabilitation programs, (3) applying novel technologies to advance rehabilitation methods and enhance outcome assessments, and (4) transferring new technology to improve functional capacity, independence, and quality of life. Each of these research focus areas works synergistically to influence the quality of life for injured service members. The purpose of this overview is to highlight the clinical research efforts of CRSR, namely how this organization engages a broad group of interdisciplinary investigators from medicine, biology, engineering, anthropology, and physiology to help solve clinically relevant problems for our service members, veterans, and their families.
C1 [Isaacson, Brad M.; Messinger, Seth D.] Uniformed Serv Univ Hlth Sci, Ctr Rehabil Sci Res, Dept Phys Med & Rehabil, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.
[Isaacson, Brad M.; Messinger, Seth D.; Wilken, Jason M.; Rabago, Christopher A.; Esposito, Elizabeth Russell; Pruziner, Alison L.; Dearth, Christopher L.; Wyatt, Marilynn; Pasquina, Paul F.] Henry M Jackson Fdn Adv Mil Med, 6720A Rockledge Dr,100, Bethesda, MD 20817 USA.
[Hendershot, Brad D.; Pruziner, Alison L.; Dearth, Christopher L.; Pasquina, Paul F.] Walter Reed Natl Mil Med Ctr, Dept Rehabil, Res & Dev Sect, 8901 Rockville Pike, Bethesda, MD 20889 USA.
[Hendershot, Brad D.; Rabago, Christopher A.; Esposito, Elizabeth Russell; Pruziner, Alison L.; Dearth, Christopher L.] Extrem Trauma & Amputat Ctr Excellence, 2748 Worth Rd,Suite 29, Joint Base San Antonio F, TX 78234 USA.
[Wilken, Jason M.; Rabago, Christopher A.; Esposito, Elizabeth Russell] Brooke Army Med Ctr, Dept Rehabil Med, Ctr Intrepid, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
[Wyatt, Marilynn] Naval Med Ctr San Diego, Gait Anal Lab, 34800 Bob Wilson Dr, San Diego, CA 92134 USA.
[Wolf, Erik] US Army Med Res, 810 Schreider St, Ft Detrick, MD 21702 USA.
[Wolf, Erik] Mat Command Clin & Rehabil Med Res Program, 810 Schreider St, Ft Detrick, MD 21702 USA.
[Cohen, Steven P.] Johns Hopkins Sch Med, Dept Anesthesiol, 600 North Wolfe St, Baltimore, MD 21205 USA.
[Cohen, Steven P.] Johns Hopkins Sch Med, Dept Crit Care Med, 600 North Wolfe St, Baltimore, MD 21205 USA.
[Cohen, Steven P.] Uniformed Serv Univ Hlth Sci, Dept Anesthesiol, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.
[Cohen, Steven P.] Uniformed Serv Univ Hlth Sci, Dept Phys Med & Rehabil, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.
[Tsao, Jack W.] Univ Tennessee, Hlth Sci Ctr, Dept Neurol, 855 Monroe Ave,Suite 415, Memphis, TN 38163 USA.
[Tsao, Jack W.] Memphis Vet Adm Med Ctr, 1030 Jefferson Ave, Memphis, TN 38104 USA.
RP Isaacson, BM (reprint author), Uniformed Serv Univ Hlth Sci, Ctr Rehabil Sci Res, Dept Phys Med & Rehabil, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.; Isaacson, BM (reprint author), Henry M Jackson Fdn Adv Mil Med, 6720A Rockledge Dr,100, Bethesda, MD 20817 USA.
OI Rabago, Christopher/0000-0002-4484-0613
FU Department of Physical Medicine and Rehabilitation, Center for
Rehabilitation Science Research, USU, Bethesda, Maryland
[HU0001-11-1-0004, HU0001-15-2-0003]
FX This work is supported by the Department of Physical Medicine and
Rehabilitation, Center for Rehabilitation Science Research, USU,
Bethesda, Maryland, awards HU0001-11-1-0004 and HU0001-15-2-0003.
NR 42
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U1 1
U2 1
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD NOV
PY 2016
VL 181
SU 4
SI SI
BP 20
EP 25
DI 10.7205/MILMED-D-15-00548
PG 6
WC Medicine, General & Internal
SC General & Internal Medicine
GA EL3EA
UT WOS:000394501200004
PM 27849457
ER
PT J
AU Stinner, DJ
AF Stinner, Daniel J.
TI Improving Outcomes Following Extremity Trauma: The Need for a
Multidisciplinary Approach
SO MILITARY MEDICINE
LA English
DT Article
ID LIMB TRAUMA; AMPUTATION; INJURIES; REHABILITATION; DISABILITY;
AFGHANISTAN; PROGRAM; COMBAT; HEALTH; IRAQ
AB Extremity injuries contribute a significant amount to the overall disability of combat-injured soldiers. Tracking patient outcomes allows military health care providers to gain a better understanding of the disability associated with various injury patterns. Only recently have orthopedic surgeons begun to collect functional outcome measures, and perhaps even more importantly, have begun to collect patient-reported outcomes. There is a growing body of evidence demonstrating the importance of a multidisciplinary approach to optimize outcomes in patients following severe extremity trauma. Tracking the outcomes of these interventions longitudinally will ultimately provide the military surgeon with an evidence-based plan to treat severe combat-related extremity injuries, leading to optimal care for future combat injured patients.
"However beautiful the strategy, you should occasionally look at the results."-Winston Churchill
C1 [Stinner, Daniel J.] Brooke Army Med Ctr, Dept Orthopaed & Rehabil, Ctr Intrepid, 3851 Rogers Brooke Dr, Ft Sam Houston, TX 78234 USA.
RP Stinner, DJ (reprint author), Brooke Army Med Ctr, Dept Orthopaed & Rehabil, Ctr Intrepid, 3851 Rogers Brooke Dr, Ft Sam Houston, TX 78234 USA.
NR 29
TC 0
Z9 0
U1 1
U2 1
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD NOV
PY 2016
VL 181
SU 4
SI SI
BP 26
EP 29
DI 10.7205/MILMED-D-15-00511
PG 4
WC Medicine, General & Internal
SC General & Internal Medicine
GA EL3EA
UT WOS:000394501200005
PM 27849458
ER
PT J
AU Rabago, CA
Wilken, JM
AF Rabago, Christopher A.
Wilken, Jason M.
TI The Prevalence of Gait Deviations in Individuals With Transtibial
Amputation
SO MILITARY MEDICINE
LA English
DT Article
ID TRANS-TIBIAL AMPUTEES; BELOW-KNEE AMPUTEES; LOWER-LIMB AMPUTEES; INTACT
LIMB; CEREBRAL-PALSY; LOW-BACK; WALKING; JOINT; SERVICEMEMBERS;
OSTEOARTHRITIS
AB Individuals with a transtibial amputation (TTA) are at increased risk for developing secondary musculoskeletal disorders as a result of multiple gait deviations. These deviations are primarily characterized using group mean comparisons, which do not establish if deviations are prevalent, of large magnitude, or both. In contrast, use of normative reference ranges and prevalence specifically identifies the percentage of individuals outside of a predefined acceptable range. The purpose of this study was to identify and characterize gait deviations in service members with unilateral TTA using group mean comparisons and normative reference ranges (able-bodied mean +/- 2 SD). Temporal spatial, kinematic, and kinetic data were collected during biomechanical gait assessments of 40 able-bodied males and 16 males with a TTA. Highly prevalent and statistically significant deviations were observed at the ankle and knee of the prosthetic limb and hip of the intact limb in the TTA group. Approximately 20% of measures that were significantly different between groups demonstrated 0% deviation prevalence. Deviations in the prosthetic limb were in agreement with literature, although most intact limb deviations were not. Further study is needed to determine the exact etiology of these deviations, and their association with the development of secondary musculoskeletal conditions.
C1 [Rabago, Christopher A.; Wilken, Jason M.] Brooke Army Med Ctr, Ctr Intrepid, Dept Rehabil Med, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
[Rabago, Christopher A.; Wilken, Jason M.] Extrem Trauma & Amputat Ctr Excellence, 2748 Worth Rd,Suite 29, Ft Sam Houston, TX 78234 USA.
RP Rabago, CA (reprint author), Brooke Army Med Ctr, Ctr Intrepid, Dept Rehabil Med, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.; Rabago, CA (reprint author), Extrem Trauma & Amputat Ctr Excellence, 2748 Worth Rd,Suite 29, Ft Sam Houston, TX 78234 USA.
OI Rabago, Christopher/0000-0002-4484-0613
NR 32
TC 0
Z9 0
U1 0
U2 0
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD NOV
PY 2016
VL 181
SU 4
SI SI
BP 30
EP 37
DI 10.7205/MILMED-D-15-00505
PG 8
WC Medicine, General & Internal
SC General & Internal Medicine
GA EL3EA
UT WOS:000394501200006
PM 27849459
ER
PT J
AU Schnall, BL
Chen, YT
Bell, EM
Wolf, EJ
Wilken, JM
AF Schnall, Barri L.
Chen, Yin-Ting
Bell, Elizabeth M.
Wolf, Erik J.
Wilken, Jason M.
TI Functional Outcomes of Service Members With Bilateral Transfemoral and
Knee Disarticulation Amputations Resulting From Trauma
SO MILITARY MEDICINE
LA English
DT Article
ID LOWER-LIMB AMPUTATION; PROSTHETIC KNEE; UNITED-STATES; STAIR-ASCENT;
VIETNAM-WAR; AMPUTEES; PERFORMANCE; FITNESS; SCALE; REHABILITATION
AB As longitudinal studies for those with bilateral transfemoral amputation (BTFA) or knee disarticulation (KD) are lacking, it is important to quantify performance measures during rehabilitation in an effort to determine reasonable expectations and trends that may influence the rehabilitation process. At initial evaluation (date of first independent ambulation) and follow up (median 135 [range = 47-300] days later), 10 participants with BTFA/KD completed 6 minute walk testing and Activity Specific Balance Confidence and Lower Extremity Functional Scale questionnaires. Of these, six participants also completed stair ambulation; ascent time and stair assessment index (SAI) scores were calculated. Patients utilized their prescribed prostheses at each visit. Participants were able to cover a significantly greater distance (135.3 [70.1] m) in 6 minutes at the follow-up visit (*p = 0.005). The change in SAI scores for stair ascent and descent was not statistically significant (p = 0.247). Stair ambulation confidence scores were significantly greater at the final visit (*p = 0.034). Stair negotiation appears to plateau early; however, confidence builds despite absence of functional gains over time. Service members with BTFAs/KDs are able to achieve functional community ambulation skills. Thus, this investigation suggests that clinicians can realign rehabilitation paradigms to shift focus towards community distance ambulation once safe stair ascent and descent is achieved.
C1 [Schnall, Barri L.; Chen, Yin-Ting; Bell, Elizabeth M.; Wolf, Erik J.] Walter Reed Natl Mil Med Ctr, Dept Rehabil, 8901 Wisconsin Ave, Bethesda, MD 20889 USA.
[Bell, Elizabeth M.; Wolf, Erik J.; Wilken, Jason M.] Extrem Trauma & Amputat Ctr Excellence, 2748 Worth Rd,Suite 29, Ft Sam Houston, TX 78234 USA.
[Wilken, Jason M.] Brooke Army Med Ctr, Dept Rehabil Med, Ctr Intrepid, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
RP Schnall, BL (reprint author), Walter Reed Natl Mil Med Ctr, Dept Rehabil, 8901 Wisconsin Ave, Bethesda, MD 20889 USA.
FU MRMC (USAMRAA); Henry M. Jackson Foundation for the Advancement of
Military Medicine
FX The authors acknowledge Ms Jenna Trout for collection and processing of
data in this study and Dr. Benjamin Darter of Virginia Commonwealth
University for his contribution to the development of the research
study. Factors Influencing Rehabilitation Effectiveness in the
Restoration of Physical Function in the Military Amputee was funded by
the Military Amputee Program through a CRADA between MRMC (USAMRAA) and
the Henry M. Jackson Foundation for the Advancement of Military
Medicine.
NR 29
TC 0
Z9 0
U1 0
U2 0
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD NOV
PY 2016
VL 181
SU 4
SI SI
BP 55
EP 60
DI 10.7205/MILMED-D-15-00546
PG 6
WC Medicine, General & Internal
SC General & Internal Medicine
GA EL3EA
UT WOS:000394501200009
PM 27849462
ER
PT J
AU Andrews, AM
Deehl, C
Rogers, RL
Pruziner, AL
AF Andrews, Anne M.
Deehl, Christina
Rogers, Reva L.
Pruziner, Alison L.
TI Core Temperature in Service Members With and Without Traumatic
Amputations During a Prolonged Endurance Event
SO MILITARY MEDICINE
LA English
DT Article
ID TRANS-TIBIAL AMPUTEES; BODY-SURFACE AREA; IRONMAN TRIATHLON; HYDRATION
STATUS; PROSTHETIC USE; PERFORMANCE; EXERCISE; THERMOREGULATION;
HYPERTHERMIA; AMBULATION
AB Introduction: Service members with traumatic amputations may be at an increased risk of elevated core body temperature, since their ability to dissipate heat may decrease with the reduction in body surface area (BSA) after injury. Elevated core temperature can impair physical performance during combat operations potentially putting the service members and their teams at risk. The purpose of this study was to compare core temperature between individuals with and without amputations during a prolonged endurance event. Materials and Methods: Twenty healthy male military service members (10 with amputations, 10 without) participated in the Bataan Memorial Death March 26.2-mile event on March 27, 2011. Data collected include BSA, body mass index, body composition, body weight before and after the event, core temperature during the event, and postevent hydration status. Body composition was measured by dual-energy X-ray absorptiometry. Body weight was measured by digital scale. Core temperature was measured by ingestible sensor. Hydration was measured by urine specific gravity. The Walter Reed Army Medical Center Institutional Review Board approved this study and participants provided written informed consent. Results: Three participants' data were not included in the analyses. No significant differences in core temperature were found between participants in both groups, and no correlation was found between core temperature and either BSA or hydration status. There was no significant difference in maximal core temperature between the groups (p = 0.27) Nearly all participants (8 control, 6 amputation) reached 38.3 C, the threshold for increased risk of heat exhaustion. No subjects reached 40.0 C, the threshold for increased risk of heat stroke. Time spent above the 38.3 C threshold was not significantly different between groups, but varied widely by participant in relation to the duration of the event. Participants without amputations finished the event faster than participants with amputations (7.9 +/- 1.4 vs. 9.6 +/- 0.96, p < 0.01), possibly indicating that participants with amputations self-selected a slower pace to attenuate increased core temperature. Conclusion: Until conclusive evidence is accumulated, it is prudent for military leaders, trainers, and military service members to closely monitor this population during physical activity to prevent heat injuries.
C1 [Andrews, Anne M.; Pruziner, Alison L.] Walter Reed Natl Mil Med Ctr, Dept Rehabil, Bethesda, MD 20889 USA.
[Andrews, Anne M.; Pruziner, Alison L.] Extrem Trauma & Amputat Ctr Excellence, 2748 Worth Rd,Suite 29, Ft Sam Houston, TX 78234 USA.
[Deehl, Christina; Rogers, Reva L.] US Army Med Dept Ctr & Sch, US Mil Baylor Univ Grad Program Nutr, Joint Base San Antonio, TX 78234 USA.
Walter Reed Army Med Ctr, 6900 Georgia Ave, Washington, DC 20307 USA.
Walter Reed Natl Mil Med Ctr, 8901 Wisconsin Ave, Bethesda, MD 20889 USA.
US Army Med Dept Ctr & Sch, 3630 Stanley Rd, Joint Base San Antonio, TX 78234 USA.
Bataan Mem Death March, White Sands Missile Range, NM 88002 USA.
RP Andrews, AM (reprint author), Walter Reed Natl Mil Med Ctr, Dept Rehabil, Bethesda, MD 20889 USA.; Andrews, AM (reprint author), Extrem Trauma & Amputat Ctr Excellence, 2748 Worth Rd,Suite 29, Ft Sam Houston, TX 78234 USA.
FU Telemedicine and Advanced Technology Research Center (TATRC)
[W81XWH-06-2-0073]; DoD-VA Extremity Trauma; Amputation Center of
Excellence
FX Military Amputee Research Program (MARP) and the Telemedicine and
Advanced Technology Research Center (TATRC) Prime Award No
W81XWH-06-2-0073. The U.S. Army Medical Research Acquisition Activity,
820 Chandler Street, Fort Detrick, MD 21701-5014 is the awarding and
administering acquisition office. It was administered by the Henry M.
Jackson Foundation for the Advancement of Military Medicine, Inc. The
DoD-VA Extremity Trauma and Amputation Center of Excellence (Public Law
110-417, National Defense Authorization Act 2009, Section 723) supported
this project.
NR 32
TC 0
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U1 0
U2 0
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD NOV
PY 2016
VL 181
SU 4
SI SI
BP 61
EP 65
DI 10.7205/MILMED-D-15-00515
PG 5
WC Medicine, General & Internal
SC General & Internal Medicine
GA EL3EA
UT WOS:000394501200010
PM 27849463
ER
PT J
AU Highsmith, MJ
Nelson, LM
Carbone, NT
Klenow, TD
Kahle, JT
Hill, OT
Maikos, JT
Kartel, MS
Randolph, BJ
AF Highsmith, M. Jason
Nelson, Leif M.
Carbone, Neil T.
Klenow, Tyler D.
Kahle, Jason T.
Hill, Owen T.
Maikos, Jason T.
Kartel, Mike S.
Randolph, Billie J.
TI Outcomes Associated With the Intrepid Dynamic Exoskeletal Orthosis
(IDEO): A Systematic Review of the Literature
SO MILITARY MEDICINE
LA English
DT Review
ID LOWER-EXTREMITY TRAUMA; LIMB SALVAGE; PRISMA STATEMENT; AMPUTATION;
PERFORMANCE; WALKING; RETURN; METAANALYSES; DISABILITY; INJURY
AB High-energy lower extremity trauma is a consequence of modern war and it is unclear if limb amputation or limb salvage enables greater recovery. To improve function in the injured extremity, a passive dynamic ankle-foot orthosis, the Intrepid Dynamic Exoskeletal Orthosis (IDEO), was introduced with specialized return to run (RTR) therapy program. Recent research suggests, these interventions may improve function and return to duty rates. This systematic literature review sought to rate available evidence and formulate empirical evidence statements (EESs), regarding outcomes associated with IDEO utilization. PubMed, CINAHL, and Google Scholar were systematically searched for pertinent articles. Articles were screened and rated. EESs were formulated based upon data and conclusions from included studies. Twelve studies were identified and rated. Subjects (n = 487, 6 females, mean age 29.4 year) were studied following limb trauma and salvage. All included studies had high external validity, whereas internal validity was mixed because of reporting issues. Moderate evidence supported development of four EESs regarding IDEO use with specialized therapy. Following high-energy lower extremity trauma and limb salvage, use of IDEO with RTR therapy can enable return to duty, return to recreation and physical activity, and decrease pain in some high-functioning patients. In higher functioning patients following limb salvage or trauma, IDEO use improved agility, power and speed, compared with no-brace or conventional bracing alternatives.
C1 [Highsmith, M. Jason; Nelson, Leif M.; Hill, Owen T.; Randolph, Billie J.] Extrem Trauma & Amputat Ctr Excellence, 2748 Worth Rd,Suite 29, Ft Sam Houston, TX 78234 USA.
[Highsmith, M. Jason; Nelson, Leif M.; Randolph, Billie J.] US Dept Vet Affairs, Rehabil & Serv, 810 Vermont Ave NW, Washington, DC 20420 USA.
[Highsmith, M. Jason; Nelson, Leif M.; Randolph, Billie J.] US Dept Vet Affairs, Prosthet Serv, 810 Vermont Ave NW, Washington, DC 20420 USA.
[Highsmith, M. Jason; Kahle, Jason T.] Univ S Florida, Morsani Coll Med, Sch Phys Therapy & Rehabil Sci, 3515 E,Fletcher Ave, Tampa, FL 33613 USA.
[Carbone, Neil T.; Maikos, Jason T.] Vet Affairs New York Harbor Healthcare Syst, 423 E,23rd St, New York, NY USA.
[Klenow, Tyler D.; Kartel, Mike S.] James A Haley Vet Adm Hosp, 13000 Bruce B Downs Blvd, Tampa, FL 33612 USA.
[Hill, Owen T.] Brooke Army Med Ctr, Headquarters & Headquarters Co, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
RP Highsmith, MJ (reprint author), Extrem Trauma & Amputat Ctr Excellence, 2748 Worth Rd,Suite 29, Ft Sam Houston, TX 78234 USA.; Highsmith, MJ (reprint author), US Dept Vet Affairs, Rehabil & Serv, 810 Vermont Ave NW, Washington, DC 20420 USA.; Highsmith, MJ (reprint author), US Dept Vet Affairs, Prosthet Serv, 810 Vermont Ave NW, Washington, DC 20420 USA.; Highsmith, MJ (reprint author), Univ S Florida, Morsani Coll Med, Sch Phys Therapy & Rehabil Sci, 3515 E,Fletcher Ave, Tampa, FL 33613 USA.
NR 32
TC 0
Z9 0
U1 0
U2 0
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD NOV
PY 2016
VL 181
SU 4
SI SI
BP 69
EP 76
DI 10.7205/MILMED-D-16-00280
PG 8
WC Medicine, General & Internal
SC General & Internal Medicine
GA EL3EA
UT WOS:000394501200012
PM 27849465
ER
PT J
AU Hill, O
Bulathsinhala, L
Eskridge, SL
Quinn, K
Stinner, DJ
AF Hill, Owen
Bulathsinhala, Lakmini
Eskridge, Susan L.
Quinn, Kimberly
Stinner, Daniel J.
TI Descriptive Characteristics and Amputation Rates With Use of Intrepid
Dynamic Exoskeleton Orthosis
SO MILITARY MEDICINE
LA English
DT Article
ID OPERATION ENDURING FREEDOM; LOWER-EXTREMITY TRAUMA; IRAQI FREEDOM;
INJURY; RETURN; WOUNDS; DUTY
AB Advancements in ankle-foot orthotic devices, such as the Intrepid Dynamic Exoskeletal Orthosis (IDEO), are designed to improve function and reduce pain of the injured lower extremity. There is a paucity of research detailing the demographics, injury patterns and amputation outcomes of patients who have been prescribed an IDEO. The purpose of this study was to describe the demographics, presenting diagnosis and patterns of amputation in patients prescribed an IDEO at the Center for the Intrepid (CFI). The study population was comprised of 624 service members who were treated at the CFI and prescribed an IDEO between 2009 and 2014. Data were extracted from the Expeditionary Medical Encounter Database, Defense Manpower Data Center, Military Health System Data Repository, and CFI patient records for demographic and injury information as well as an amputation outcome. The most common injury category that received an IDEO prescription was injuries at or surrounding the ankle joint (25.0%), followed by tibia injuries (17.5%) and nerve injuries below the knee (16.4%). Over 80% of the sample avoided amputation within a one year time period using this treatment modality. Future studies should longitudinally track IDEO users for a longer term to determine the long term viability of the device.
C1 [Hill, Owen; Bulathsinhala, Lakmini; Stinner, Daniel J.] Brooke Army Med Ctr, Ctr Intrepid, Dept Rehabil Med, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
[Hill, Owen; Bulathsinhala, Lakmini; Eskridge, Susan L.; Quinn, Kimberly; Stinner, Daniel J.] Extrem Trauma & Amputat Ctr Excellence, 2748 Worth Rd,Suite 29, Jbsa Ft Sam Houston, TX 78234 USA.
[Eskridge, Susan L.; Quinn, Kimberly] Naval Hlth Res Ctr, Dept Med Modeling & Simulat, Ryne Rd 329, San Diego, CA 92152 USA.
RP Hill, O (reprint author), Brooke Army Med Ctr, Ctr Intrepid, Dept Rehabil Med, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.; Hill, O (reprint author), Extrem Trauma & Amputat Ctr Excellence, 2748 Worth Rd,Suite 29, Jbsa Ft Sam Houston, TX 78234 USA.
FU [60808]
FX This study was supported by work unit 60808.
NR 14
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U1 0
U2 0
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD NOV
PY 2016
VL 181
SU 4
SI SI
BP 77
EP 80
DI 10.7205/MILMED-D-16-00281
PG 4
WC Medicine, General & Internal
SC General & Internal Medicine
GA EL3EA
UT WOS:000394501200013
PM 27849466
ER
PT J
AU Hare, JP
Misialek, LH
Palis, K
Wong, C
AF Hare, Jean Paul
Misialek, Leah Hanson
Palis, Katy
Wong, Charmin
TI Using Cranial Electrotherapy Stimulation Therapy to Treat Behavioral
Health Symptoms in a Combat Operational Setting
SO MILITARY MEDICINE
LA English
DT Editorial Material
C1 [Hare, Jean Paul] Headquarters Co, Behav Hlth, Med Sect, Mil Informat Support Grp Airborne 4, 3350 Sapper St, Ft Bragg, NC 28310 USA.
[Misialek, Leah Hanson; Palis, Katy; Wong, Charmin] Charlie Co, Behav Hlth, Brigade Support Med Co 704, BDE 2,Infantry Div 4, 10138 Warfighter Rd, Ft Carson, CO 80913 USA.
RP Hare, JP (reprint author), Headquarters Co, Behav Hlth, Med Sect, Mil Informat Support Grp Airborne 4, 3350 Sapper St, Ft Bragg, NC 28310 USA.
NR 3
TC 0
Z9 0
U1 0
U2 0
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD NOV
PY 2016
VL 181
IS 11
BP 1410
EP 1412
DI 10.7205/MILMED-D-16-00019
PG 3
WC Medicine, General & Internal
SC General & Internal Medicine
GA EL3DS
UT WOS:000394500400047
PM 27849474
ER
PT J
AU Andrews, MA
Paolino, ND
DeZee, KJ
Hemann, B
AF Andrews, Mary A.
Paolino, Nathalie D.
DeZee, Kent J.
Hemann, Brian
TI Perspective of the Graduating Medical Student: The Ideal Curriculum for
the Fourth Year of Undergraduate Medical Education
SO MILITARY MEDICINE
LA English
DT Article
ID QUALITY IMPROVEMENT; SCHOOL; ASSOCIATION; STATE
AB Objective: To explore medical students' perspective regarding the fourth year of medical school and common educational activities thereof. Methods: The authors surveyed students graduating in 2012 with a military service obligation about the importance of common fourth-year activities, the proportion of the fourth year devoted to these activities, and important considerations for the fourth-year curriculum. The authors calculated mean importance scores for educational activities and mean proportions of the fourth year that should be devoted to certain activities. Two reviewers independently coded free-text answers to identify and calculate frequencies for common themes. Results: The response rate was 40% (376/942). Participants rated activities related to improving clinical skills and securing the residency of their choice as more than activities such as learning business skills, conducting research, and studying basic sciences. Participants indicated that electives and direct patient care should comprise the majority of the fourth year and frequently mentioned improving specialty-specific clinical skills, pursuing personal medical interests, and taking time to relax as important fourth-year themes. Conclusions: Students value activities related to securing and succeeding in their chosen residency and the opportunity to pursue electives and take vacation. Faculty should consider the student perspective when reforming curricula.
C1 [Andrews, Mary A.; Paolino, Nathalie D.; DeZee, Kent J.; Hemann, Brian] Uniformed Serv Univ Hlth Sci, Dept Med, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.
[Andrews, Mary A.; Hemann, Brian] Walter Reed Natl Mil Med Ctr, Dept Med, 8901 Rockville Pike, Bethesda, MD 20889 USA.
[Paolino, Nathalie D.] Madigan Army Med Ctr, Dept Med, 9040 Jackson Ave, Tacoma, WA 98431 USA.
[DeZee, Kent J.] Tripler Army Med Ctr, Dept Med, 1 Jarrett White Rd, Honolulu, HI 96859 USA.
RP Andrews, MA (reprint author), Uniformed Serv Univ Hlth Sci, Dept Med, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.; Andrews, MA (reprint author), Walter Reed Natl Mil Med Ctr, Dept Med, 8901 Rockville Pike, Bethesda, MD 20889 USA.
NR 20
TC 0
Z9 0
U1 0
U2 0
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD NOV
PY 2016
VL 181
IS 11
BP E1455
EP E1463
DI 10.7205/MILMED-D-15-00402
PG 9
WC Medicine, General & Internal
SC General & Internal Medicine
GA EL3DS
UT WOS:000394500400002
PM 27849476
ER
PT J
AU Cardile, AP
Littell, CT
Backlund, MG
Heipertz, RA
Brammer, JA
Palmer, SM
Vento, TJ
Ortiz, FA
Rosa, WR
Major, MJ
Garman, PM
AF Cardile, Anthony P.
Littell, Christopher T.
Backlund, Michael G.
Heipertz, Richard A.
Brammer, Jerod A.
Palmer, Sean M.
Vento, Todd J.
Ortiz, Felix A.
Rosa, William R.
Major, Michael J.
Garman, Patrick M.
TI Deployment of the 1st Area Medical Laboratory in a Split-Based
Configuration During the Largest Ebola Outbreak in History
SO MILITARY MEDICINE
LA English
DT Article
ID INFECTIOUS-DISEASES; PATIENT-MANAGEMENT; MILITARY PERSONNEL;
HEALTH-PROBLEMS; US MILITARY; AFGHANISTAN; SUPPORT; IMPACT; ILLNESS;
UNIT
AB Background: The U.S. Army 1st Area Medical Laboratory (1st AML) is currently the only deployable medical CBRNE (Chemical, Biological, Radiological, Nuclear, and Explosives) laboratory in the Army's Forces Command. In support of the United States Agency for International Development Ebola response, the U.S. military initiated Operation United Assistance (OUA), and deployed approximately 2,500 service members to support the Government of Liberia's Ebola control efforts. Due to its unique molecular diagnostic and expeditionary capabilities, the 1st AML was ordered to deploy in October of 2014 in support of OUA via establishment of Ebola testing laboratories. To meet the unique mission requirements of OUA, the unit was re-organized to operate in a split-based configuration and sustain four separate Ebola testing laboratories. Methods: This article is a review of the 1st AML's OUA participation in a split-based configuration. Topics highlighted include pre-deployment planning/training, operational/logistical considerations in fielding/withdrawing laboratories, laboratory testing results, disease and non-battle injuries, and lessons learned. Findings: Fielding the 1st AML in a split-based configuration required careful pre-deployment planning, additional training, optimal use of personnel, and the acquisition of additional laboratory equipment. Challenges in establishing and sustaining remote laboratories in Liberia included: difficulties in transportation of equipment due to poor road infrastructure, heavy equipment unloading, and equipment damage during transit. Between November 26, 2014 and February 18, 2015 the four 1st AML labs successfully tested blood samples from patients and oral swabs collected by burial teams in rural Liberia. The most significant equipment malfunction during laboratory operations was generators powering the labs, with the same problem impacting headquarters. Generator failures delayed laboratory operations/result reporting, and put temperature sensitive reagents at risk. None of the 22 1st AML soldiers (at remote labs or headquarters) had an Ebola exposure, none were infected with malaria or other tropical diseases, and none required evacuation from the time deployed to remote sites. The primary medical condition encountered was acute gastroenteritis, and within the first week of arrival to Liberia, 19 (86%) soldiers were affected. Discussion/Impact/Recommendations: With proper planning and training, the 1st AML can successfully conduct split-based operations in an outbreak setting, and this capability can be utilized in future operations. The performance of the 1st AML during the current Ebola outbreak highlights the value of this asset, and the need to continue its evolution to support U.S. military operations.
C1 [Cardile, Anthony P.; Backlund, Michael G.; Heipertz, Richard A.; Brammer, Jerod A.; Palmer, Sean M.; Ortiz, Felix A.; Rosa, William R.; Major, Michael J.; Garman, Patrick M.] 1st Area Med Lab Bldg 5116,Bel Air St, Aberdeen Proving Ground, MD 21005 USA.
[Littell, Christopher T.] Uniformed Serv Univ Hlth Sci, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.
[Vento, Todd J.] Brooke Army Med Ctr, Infect Dis Serv, 3551 Roger Brooke Dr, Jbsa Ft Sam Houston, TX 78234 USA.
RP Cardile, AP (reprint author), 1st Area Med Lab Bldg 5116,Bel Air St, Aberdeen Proving Ground, MD 21005 USA.
FU Liberia Institute of Biomedical Research
FX The authors would like to acknowledge the 20th Chemical, Biological,
Radiological, Nuclear, and Explosives Command, the 44th Medical Brigade,
U.S. Army Medical Research Institute of Infectious Diseases, the Joint
Program Executive Office for Chemical and Biological Defense, and the
Defense Threat Reduction Agency for assistance in deployment
preparation. We would like to thank the 101st Airborne Division (Air
Assault), and all supporting commands during deployment in helping to
make our mission a success. We would also like to acknowledge the Navy
personnel who staffed the laboratories at Bong county and Island clinic,
and U.S. Army Medical Research Institute of Infectious Diseases
personnel who staffed and continue to support the Liberia Institute of
Biomedical Research. Finally, we wish to recognize all of the
Soldier-Scientists of the 1st AML who deployed to Liberia who displayed
discipline, resilience, and outstanding technical competence while
completing the mission.
NR 21
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PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD NOV
PY 2016
VL 181
IS 11
BP E1675
EP E1684
DI 10.7205/MILMED-D-15-00484
PG 10
WC Medicine, General & Internal
SC General & Internal Medicine
GA EL3DS
UT WOS:000394500400033
PM 27849507
ER
PT J
AU Clemens, MS
Heafner, TA
Watson, JDB
Aden, JK
Rasmussen, TE
Glasgow, SC
AF Clemens, Michael S.
Heafner, Thomas A.
Watson, J. Devin B.
Aden, James K., III
Rasmussen, Todd E.
Glasgow, Sean C.
TI Quality of Life in United States Veterans With Combat-Related Ostomies
From Iraq and Afghanistan
SO MILITARY MEDICINE
LA English
DT Article
ID STOMA COMPLICATIONS; COLORECTAL TRAUMA
AB Objective: Assess the impact of ostomy formation on quality of life for U. S. Service Members. Methods: U. S. personnel sustaining colorectal trauma from 2003 to 2011 were identified using the Department of Defense Trauma Registry. A cross-sectional observational study was conducted utilizing prospective interviews with standard survey instruments. Primary outcome measures were the Stoma Quality of Life Scale and Veterans RAND 36 scores and subjective responses. Patients with colorectal trauma not requiring ostomy served as controls. Results: Of 177 available patients, 90 (50.8%) male veterans consented to participate (55 ostomy, 35 control). No significant differences were observed between ostomy and control groups for Injury Severity Score (25.6 +/- 9.9 vs. 22.9 +/- 11.8, p = 0.26) or mechanism of injury (blast: 55 vs. 52%, p = 0.75); nonostomates had fewer anorectal injuries (3.2 vs. 47.9%, p < 0.01). Median follow-up was 6.7 years. Veterans RAND-36 Physical and Mental Component Scores were similar between groups. About 45.8% of ostomates were willing-to-trade a median of 10 years (interquartile range = 5-15) of their remaining life for gastrointestinal continuity. At last follow-up, 95.9% of respondents' combat-related ostomies were reversed with a median duration of 6 (range = 3-19) months diverted. Conclusions: Ostomy creation in a combat environment remains safe and does not have a quantifiable impact on long-term quality of life.
C1 [Clemens, Michael S.; Heafner, Thomas A.; Watson, J. Devin B.] San Antonio Mil Med Ctr, Dept Surg, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78219 USA.
[Aden, James K., III] US Army, Inst Surg Res, Dept Epidemiol, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
[Rasmussen, Todd E.] US Combat Casualty Care Res Program, 504 Scott St, Ft Detrick, MD 21702 USA.
[Glasgow, Sean C.] US Air Force, Ctr Sustainment Trauma & Resuscitat Skills C STAR, 3635 Vista Grand Blvd, St Louis, MO 63110 USA.
[Glasgow, Sean C.] Washington Univ, Sch Med, Dept Surg, 660 South Euclid Ave,Campus Box 8109, St Louis, MO 63110 USA.
RP Clemens, MS (reprint author), San Antonio Mil Med Ctr, Dept Surg, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78219 USA.
FU Defense Health Program
FX The authors thank Julie E. Engel, RN, lead clinical research nurse on
the USAISR J-STOMA project, for her assistance with this study. Research
was funded by Defense Health Program FY2012 program 6.7 grant (Principal
Investigator: Lt Col Sean C. Glasgow). The Veterans RAND 36 Item Health
Survey (VR-36) was used with written permission.
NR 22
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PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD NOV
PY 2016
VL 181
IS 11
BP E1569
EP E1574
DI 10.7205/MILMED-D-16-00147
PG 6
WC Medicine, General & Internal
SC General & Internal Medicine
GA EL3DS
UT WOS:000394500400017
PM 27849491
ER
PT J
AU Connor, RR
Boivin, MR
Packnett, ER
Toolin, CF
Cowan, DN
AF Connor, Ricardford R.
Boivin, Michael R.
Packnett, Elizabeth R.
Toolin, Christine F.
Cowan, David N.
TI The Relationship Between Deployment Frequency and Cumulative Duration,
and Discharge for Disability Retirement Among Enlisted Active Duty
Soldiers and Marines
SO MILITARY MEDICINE
LA English
DT Article
ID UK ARMED-FORCES; RISK-FACTORS; US ARMY; TEMPORAL TRENDS; U.S. ARMY;
HEALTH; AFGHANISTAN; PERSONNEL; INJURIES; IMPACT
AB Background: The frequency and duration of deployments associated with increased morbidity is a significant concern for force health protection within the military population. Understanding the association between deployment and disability may provide a clearer understanding of factors adversely affecting U.S. military force readiness. Methods: A case- control analysis was conducted using records on enlisted active duty personnel in the Army and Marine Corps who were evaluated for a musculoskeletal disability and received a final disability disposition between FY 2003 and 2012. The study compared deployment, deployment frequency, and total time deployed in personnel who received musculoskeletal disability retirement to those with a musculoskeletal disability discharge other than retirement. Results: For females and males in either service, any deployment was associated with an increased risk of disability retirement (adjusted odds ratios [aOR] [95% confidence intervals (CI)]: males 1.76 [1.65- 1.87]; females 1.41 [1.21- 1.64]). Furthermore, increasing number of deployments (3+ deployments males aOR [95% CI]: 2.21 [1.92-2.53]) and time spent deployed (24+ months Army Males aOR [95% CI]: 2.07 [1.79- 2.40]) significantly increased the odds for disability retirement. Conclusion: Increasing frequency and duration of military deployments has an increased risk of disability retirement in service members with a musculoskeletal disability. Further research on this relationship is needed in a more representative sample of the U. S. military population.
C1 [Connor, Ricardford R.; Boivin, Michael R.; Packnett, Elizabeth R.; Toolin, Christine F.; Cowan, David N.] Walter Reed Army Inst Res, Prevent Med Branch, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
[Connor, Ricardford R.; Packnett, Elizabeth R.; Toolin, Christine F.; Cowan, David N.] ManTech Int Corp, ManTech Hlth, 13755 Sunrise Valley Dr,Suite 500, Herndon, VA 20171 USA.
RP Connor, RR (reprint author), Walter Reed Army Inst Res, Prevent Med Branch, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.; Connor, RR (reprint author), ManTech Int Corp, ManTech Hlth, 13755 Sunrise Valley Dr,Suite 500, Herndon, VA 20171 USA.
FU Defense Health Program
FX The authors thank COL Earl H. Lynch, MC, USAR, and LTC Paul O. Kwon,
Director, Walter Reed Army Institute of Research, Preventive Medicine
Branch, for their careful review of the manuscript and Ms. Janice Gary,
Preventive Medicine Branch, ManTech International Corporation, for her
administrative support. This study was reviewed and approved by the
Walter Reed Army Institute of Research Institutional Review Board. This
research was funded by the Defense Health Program.
NR 30
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PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD NOV
PY 2016
VL 181
IS 11
BP E1532
EP E1539
DI 10.7205/MILMED-D-16-00016
PG 8
WC Medicine, General & Internal
SC General & Internal Medicine
GA EL3DS
UT WOS:000394500400012
PM 27849486
ER
PT J
AU Friedl, KE
Breivik, TJ
Carter, R
Leyk, D
Opstad, PK
Taverniers, J
Trousselard, M
AF Friedl, Karl E.
Breivik, Torbjorn J.
Carter, Robert, III
Leyk, Dieter
Opstad, Per Kristian
Taverniers, John
Trousselard, Marion
TI Soldier Health Habits and the Metabolically Optimized Brain
SO MILITARY MEDICINE
LA English
DT Review
ID POSTTRAUMATIC-STRESS-DISORDER; PROLONGED PHYSICAL STRAIN; MILITARY
RISK-FACTORS; SLEEP-DEPRIVATION; ALZHEIMERS-DISEASE; CALORIE DEFICIENCY;
CORTISOL SECRETION; PARKINSONS-DISEASE; DAYTIME SLEEPINESS;
EMOTIONAL-STRESS
AB Human performance enhancement was the subject of a NATO workshop that considered the direct benefits of individual soldier health and fitness habits to brain health and performance. Some of the important health and fitness include physical activity and purposeful exercise, nutritional intake, sleep and rest behaviors, psychological outlook and mindfulness, and other physiologically based systemic challenges such as thermal exposure. These influences were considered in an integrated framework with insights contributed by each of five participating NATO member countries using representative research to highlight relevant interrelationships. Key conclusions are that (1) understanding the neurobiological bases and consequences of personal health behaviors is a priority for soldier performance research, and this also involves long-term brain health consequences to veterans and (2) health and fitness habits have been underappreciated as reliably effective performance enhancers and these should be preferred targets in the development of scientifically based recommendations for soldier brain health and performance.
C1 [Friedl, Karl E.] US Army, Environm Med Res Inst, Oak Ridge Res Inst Sci & Educ, Knowledge Preservat Program, Natick, MA 01760 USA.
[Friedl, Karl E.] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94122 USA.
[Breivik, Torbjorn J.] Skaregata 3, N-6002 Alesund, Norway.
[Breivik, Torbjorn J.; Opstad, Per Kristian] Norwegian Def Res Estab, N-2007 Kjeller, Norway.
[Carter, Robert, III] US Army, Inst Surg Res, 3698 Chambers Rd, Ft Sam Houston, TX 78234 USA.
[Carter, Robert, III] Univ Texas Hlth Sci Ctr San Antonio, Dept Emergency Med, 7703 Floyd Curl Dr, San Antonio, TX 78229 USA.
[Leyk, Dieter] Bundeswehr Med Serv, Cent Inst, Dept Mil Ergon & Exercise Physiol, Andernacher Str 100, D-56070 Koblenz, Germany.
[Leyk, Dieter] German Sport Univ Cologne, Res Grp Epidemiol Performance, Cologne, Germany.
[Taverniers, John] Royal Mil Acad, Dept Behav Sci, Renaissancelaan 30, Brussels, Belgium.
[Trousselard, Marion] Inst Rech Biomed Armees, Dept Neurosci & Contraintes Operat, Unite Neurophysiol Stress, F-91223 Bretigny Sur Orge, France.
RP Friedl, KE (reprint author), US Army, Environm Med Res Inst, Oak Ridge Res Inst Sci & Educ, Knowledge Preservat Program, Natick, MA 01760 USA.; Friedl, KE (reprint author), Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94122 USA.
FU NATO Research and Technology Office
FX This review represents a synthesis of discussions by members of NATO
Human Factors in Medicine (HFM) 219 panel, "Neuroperformance Enhancement
Strategies: The Metabolically Optimized Brain." These discussions
included shared open source publications, bilateral and multinational
discussions between 2010 and 2015, and presentations at an HFM-219
meeting at the Swabian Conference Center, Patch Barracks, Stuttgart,
Germany, November 6 and 7, 2012. This workshop built on the foundation
of an earlier NATO symposium, HFM-181 "Human Performance Enhancement for
NATO Military Operations (Science, Technology, and Ethics)" held in
Sofia, Bulgaria, October 5 to 7, 2009. This project was conducted under
the auspices of the NATO Research and Technology Office. Each country
was responsible for financial support of their respective member
participants.
NR 131
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PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD NOV
PY 2016
VL 181
IS 11
BP E1499
EP E1507
DI 10.7205/MILMED-D-15-00464
PG 9
WC Medicine, General & Internal
SC General & Internal Medicine
GA EL3DS
UT WOS:000394500400009
PM 27849483
ER
PT J
AU Gaydos, JC
Mallon, TM
Rice, WA
AF Gaydos, Joel C.
Mallon, Timothy M.
Rice, William A.
TI The US Army Occupational and Environmental Medicine Residency at
Aberdeen Proving Ground, Maryland: 1960-1996
SO MILITARY MEDICINE
LA English
DT Article
AB Background: Reorganization of the Army and critical assessment of Army Graduate Medical Education programs prompted the Occupational and Environmental Medicine (OEM) Consultant to the Army Surgeon General to initiate a review of current Army OEM residency training. Available information indicated the Army OEM residency at Aberdeen Proving Ground, MD, was the first and longest operating Army OEM residency. Describing this residency was identified as the first step in the review, with the objectives of determining why the residency was started and sustained and its relevance to the needs of the Army. Methods: Records possibly related to the residency were reviewed, starting with 1954 since certification of physicians as Occupation Medicine specialists began in 1955. Interviews were conducted with selected physicians who had strong affiliations with the Army residency and the practice of Army OEM. Findings: The Army OEM residency began in 1960 and closed in 1996 with the transfer of Army OEM residency training to the Uniformed Services University of the Health Sciences, Bethesda, MD. Over 36 years, 47 uniformed residency graduates were identified; 44 were from the Army. Forty graduated between 1982 and 1996. The OEM residency was part of a dynamic cycle. Uniformed OEM leaders identified the knowledge and skills required of military OEM physicians and where these people should be stationed in the global Army. Rotations at military sites to acquire the needed knowledge and skills were integrated into the residency. Residency graduates were assigned to positions where they were needed. Having uniformed residents and preceptors facilitated the development of trust with military leaders and access to areas where OEM physician skills and knowledge could have a positive impact. Early reports indicated the residency was important in recruiting and retaining OEM physicians, with emphasis placed on supporting the Army industrial base. The late 1970s into the 1990s was a more dynamic period. There was heightened interest in environmental protection and restoration of military installations, and in the threats posed by nuclear, biological and chemical weapons. Additionally, President Reagan initiated a military buildup that brought new health risks to soldiers who would use and maintain modern equipment. Army OEM physicians were required to possess competencies in many areas, to include depots in the Army industrial base, occupational health for the soldier for exposures like carbon monoxide in armored vehicles, military unique exposures like those from chemical threat agents, and environmental medicine to assess health risks on contaminated U. S. military sites and from exposures of deployed forces. These offered interesting OEM training opportunities that challenged residents in the program and helped recruit new residents. Discussion: The strength of the first Army OEM residency was that it was part of a dynamic cycle that consisted of identifying and defining Army OEM needs, training physicians to meet those needs and assigning residency graduates to positions where they would have a positive impact. This paradigm can be used as the basis for contemporary assessments of the Army's need for uniformed OEM physicians and a uniformed OEM residency program.
C1 [Gaydos, Joel C.; Rice, William A.] US Army, Occupat & Environm Med, Publ Hlth Ctr, Aberdeen Proving Ground, MD 21010 USA.
[Mallon, Timothy M.] Uniformed Serv Univ Hlth Sci, Occupat & Environm Med Residency, Bethesda, MD 20814 USA.
RP Gaydos, JC (reprint author), US Army, Occupat & Environm Med, Publ Hlth Ctr, Aberdeen Proving Ground, MD 21010 USA.
NR 13
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PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD NOV
PY 2016
VL 181
IS 11
BP E1637
EP E1643
DI 10.7205/MILMED-D-16-00118
PG 7
WC Medicine, General & Internal
SC General & Internal Medicine
GA EL3DS
UT WOS:000394500400026
PM 27849500
ER
PT J
AU Lertsethtakarn, P
Nakjarung, K
Silapong, S
Neesanant, P
Sakpaisal, P
Bodhidatta, L
Liu, J
Houpt, E
Velasco, JM
Macareo, LR
Swierczewski, BE
Mason, CJ
AF Lertsethtakarn, Paphavee
Nakjarung, Kaewkanya
Silapong, Sasikorn
Neesanant, Pimmnapar
Sakpaisal, Pimmada
Bodhidatta, Ladaporn
Liu, Jie
Houpt, Eric
Velasco, John Mark
Macareo, Louis R.
Swierczewski, Brett E.
Mason, Carl J.
TI Detection of Diarrhea Etiology Among US Military Personnel During
Exercise Balikatan 2014, Philippines, Using TaqMan Array Cards
SO MILITARY MEDICINE
LA English
DT Article
ID ENTEROAGGREGATIVE ESCHERICHIA-COLI; TRAVELERS DIARRHEA; PATHOGENICITY
ISLAND; ENTEROPATHOGENS; DEPLOYMENT; INFECTION; COHORT; FORCE; ASSAY;
PANEL
AB Background: Military personnel are vulnerable to diarrhea. Diarrheal disease is common when deployed for operations or exercise in developing countries. Although diarrheal disease is transient, cumulative time lost and medical asset can have a significant impact on military operations. Currently, diagnostics of diarrheal etiology typically relies on a mixture of conventional bacteriology, enzyme-linked immunosorbent assay, and polymerase chain reaction (PCR)-based methods including real-time PCR. These methods, however, can be time and labor intensive, although the identification of diarrheal etiology needs to be informative and rapid for treatment and prevention. Real-time PCR has been increasingly used to identify pathogens. Real-time PCR panels of common diarrheal pathogens have been developed, but several diarrheal pathogens are not included in the panel. An expanded and customizable panel to detect diarrhea etiology has been developed employing TaqMan Array Card (TAC) technology. TAC performs 384 real-time PCR reactions simultaneously. As currently configured for diarrheal disease by the University of Virginia, a maximum of 8 samples can be tested simultaneously with approximately 48 target pathogens per sample including bacteria, fungi, helminths, protozoan parasites, and viruses. TAC diarrheal disease panels have been successfully applied to detect pathogens in acute diarrheal stool samples from young children in several international multicenter diarrhea studies. Methods: In this study, TAC was applied to stool samples collected under an approved human use protocol from military personnel with acute diarrhea participating in the annual joint military exercise, Balikatan, between the Republic of the Philippines and the United States in 2014. Several established pathogen-specific real-time PCR detection assays were also performed in parallel for comparative purposes. Findings: TAC was applied to 7 stool samples. Campylobacter spp. was the most common diarrheal disease pathogen detected. Results from TAC matched 5 out of 6 pathogen specific real-time PCR assays. TAC required a total of 5-6 hours to complete all the procedures from nucleic acid extraction and data analysis, whereas a minimum of 18 hours and 4 hours are required for conventional bacteriology and enzyme-linked immunosorbent assay, respectively, per pathogen. Discussion: With TAC, pathogen load can be estimated from the amount of nucleic acid present for each pathogen, which can be analyzed further to better determine pathogen attribution and to compare pathogen load between case and control samples. Unfortunately, such correlative analysis was not possible because of the limited sample size available in this study. A larger sample size is needed for further evaluation of TAC on a specific population set, including military personnel. Regardless, TAC was found to be a useful and functional diagnostic platform that is less time-consuming, easy to use with high reproducibility, and costs less per sample compared to the current typically employed methods. The successful application of TAC in acute diarrhea stool samples from a US military population in the Philippines demonstrates its versatility as a potential candidate for a next-generation diagnostics platform.
C1 [Lertsethtakarn, Paphavee; Nakjarung, Kaewkanya; Silapong, Sasikorn; Neesanant, Pimmnapar; Sakpaisal, Pimmada; Bodhidatta, Ladaporn; Swierczewski, Brett E.; Mason, Carl J.] Armed Forces Res Inst Med Sci, Dept Enter Dis, 315-6 Rajvithi Rd, Bangkok 10400, Thailand.
[Velasco, John Mark; Macareo, Louis R.] Armed Forces Res Inst Med Sci, Dept Virol, 315-6 Rajvithi Rd, Bangkok 10400, Thailand.
[Liu, Jie; Houpt, Eric] Univ Virginia, Div Infect Dis & Int Hlth, POB 801363, Charlottesville, VA 22908 USA.
RP Lertsethtakarn, P (reprint author), Armed Forces Res Inst Med Sci, Dept Enter Dis, 315-6 Rajvithi Rd, Bangkok 10400, Thailand.
FU Armed Forces Health Surveillance Center's Global Emerging Infections
Surveillance and Response System, Silver Spring, Maryland
FX The authors would like to thank Maria Theresa Valderama, RMT, MPH;
Kathyleen Nogrado, MSPH from the Department of Virology, Tippa
Wongstitwilairoong, MSc (CS and CIS), BSc, from the Department of
Epidemiology and Disease Surveillance; Boonchai Wongstitwilairoong, BSc,
from the Department of Enteric Diseases; and United States Army Medical
Directorate-Armed Forces Research Institute of Medical Sciences for
sample collection and processing support. This work was funded by The
Armed Forces Health Surveillance Center's Global Emerging Infections
Surveillance and Response System, Silver Spring, Maryland.
NR 35
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PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD NOV
PY 2016
VL 181
IS 11
BP E1669
EP E1674
DI 10.7205/MILMED-D-15-00227
PG 6
WC Medicine, General & Internal
SC General & Internal Medicine
GA EL3DS
UT WOS:000394500400032
PM 27849506
ER
PT J
AU Mayer, JM
Childs, JD
Neilson, BD
Chen, HN
Koppenhaver, SL
Quillen, WS
AF Mayer, John M.
Childs, John D.
Neilson, Brett D.
Chen, Henian
Koppenhaver, Shane L.
Quillen, William S.
TI Effect of Lumbar Progressive Resistance Exercise on Lumbar Muscular
Strength and Core Muscular Endurance in Soldiers
SO MILITARY MEDICINE
LA English
DT Article
ID LOW-BACK-PAIN; EXTENSION STRENGTH; PELVIC STABILIZATION;
RANDOMIZED-TRIAL; FREQUENCY; PROGRAM; INJURY
AB Objectives: Low back pain is common, costly, and disabling for active duty military personnel and veterans. The evidence is unclear on which management approaches are most effective. The purpose of this study was to assess the effectiveness of lumbar extensor high-intensity progressive resistance exercise (HIPRE) training versus control on improving lumbar extension muscular strength and core muscular endurance in soldiers. Methods: A randomized controlled trial was conducted with active duty U. S. Army Soldiers (n = 582) in combat medic training at Fort Sam Houston, Texas. Soldiers were randomized by platoon to receive the experimental intervention (lumbar extensor HIPRE training, n = 298) or control intervention (core stabilization exercise training, n = 284) at one set, one time per week, for 11 weeks. Lumbar extension muscular strength and core muscular endurance were assessed before and after the intervention period. Results: At 11-week follow-up, lumbar extension muscular strength was 9.7% greater (p = 0.001) for HIPRE compared with control. No improvements in core muscular endurance were observed for HIPRE or control. Conclusions: Lumbar extensor HIPRE training is effective to improve isometric lumbar extension muscular strength in U.S. Army Soldiers. Research is needed to explore the clinical relevance of these gains.
C1 [Mayer, John M.; Quillen, William S.] Univ S Florida, Sch Phys Therapy & Rehabil Sci, Morsani Coll Med, 12901 Bruce B Downs Blvd,MDC77, Tampa, FL 33647 USA.
[Childs, John D.; Koppenhaver, Shane L.] Baylor Univ, Doctoral Program Phys Therapy, US Army, 3630 Stanley Rd,Bldg 2841,Suite 1301, Joint Base San Antonio F, TX 78234 USA.
[Neilson, Brett D.] Adv Mil Med Inc, Henry M Jackson Fdn, 6720 Rockledge Dr, Bethesda, MD 20817 USA.
[Chen, Henian] Univ S Florida, Dept Epidemiol & Biostat, Coll Publ Hlth, 13201 Bruce B Downs Blvd,MDC 56, Tampa, FL 33612 USA.
RP Mayer, JM (reprint author), Univ S Florida, Sch Phys Therapy & Rehabil Sci, Morsani Coll Med, 12901 Bruce B Downs Blvd,MDC77, Tampa, FL 33647 USA.
FU U.S. Department of Defense, Congressionally Directed Medical Research
Program [W81XWH-11-2-0170]; MedX (Ocala, Florida)
FX This study was funded by the U.S. Department of Defense, Congressionally
Directed Medical Research Program (W81XWH-11-2-0170). MedX (Ocala,
Florida) loaned to the University of South Florida the strength testing
and exercise training equipment used in this study.; The University of
South Florida has received other equipment donations, and John M. Mayer
has received research funds from MedX (Ocala, Florida).
NR 27
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PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD NOV
PY 2016
VL 181
IS 11
BP E1615
EP E1622
DI 10.7205/MILMED-D-15-00543
PG 8
WC Medicine, General & Internal
SC General & Internal Medicine
GA EL3DS
UT WOS:000394500400023
PM 27849497
ER
PT J
AU Roy, TC
Piva, SR
Christiansen, BC
Lesher, JD
Doyle, PM
Waring, RM
Irrgang, JJ
Moore, CG
Brininger, TL
Sharp, MA
AF Roy, Tanja C.
Piva, Sara R.
Christiansen, Bryan C.
Lesher, Jonathan D.
Doyle, Peter M.
Waring, Rachel M.
Irrgang, James J.
Moore, Charity G.
Brininger, Teresa L.
Sharp, Marilyn A.
TI Heavy Loads and Lifting Are Risk Factors for Musculoskeletal Injuries in
Deployed Female Soldiers
SO MILITARY MEDICINE
LA English
DT Article
ID OPERATIONS IRAQI FREEDOM; US ARMY; ENDURING FREEDOM; AFGHANISTAN; WOMEN;
BACK; ILLNESS; FLEXION; MODEL; SPINE
AB The purpose of this prospective cohort study was to investigate physical, occupational, and psychosocial risk factors for musculoskeletal injuries (MSI) in deployed female soldiers. Before deployment, participants completed performance testing and surveys and after deployment an additional survey detailing occupational demands and MSI. Data analyzed found 57/160 (36%) suffered 78 MSI. In unadjusted analyses, these factors increased the relative risk (RR, 95% confidence interval) of injury: wearing an average load > 10% body weight (BW) (RR = 2.00, 1.31-4.57), wearing an average load > 1 hour (RR = 2.44, 1.30-4.57), heaviest load worn > 15% BW (RR = 5.83, 1.51-22.50), wearing a backpack (RR = 1.82, 1.23-2.80), wearing body armor > 1 hour (RR = 1.62, 1.002-2.62), lifting objects weighing above 22.68 kg (RR = 1.96, 1.08-3.57), lifting objects one to two times (RR = 1.73, 1.002-2.97), carrying objects > 7.62 m (RR = 2.01, 1.19-3.42), and Y Balance composite score < 95.23 (RR = 1.71, 1.13-2.60). The best logistic regression model predicting MSI was average load as % BW (odds ratio [OR] = 1.04, 1.01-1.07), heaviest load as % BW (OR = 1.03, 1.01-1.05), average repetitions lifting objects (OR = 1.07, 1.01-1.14), and sit-ups (OR = 0.93, 0.93-0.99). Results indicate that risk of MSI in deployed female soldiers increased with heavier equipment worn and more repetitious lifting, although more performing more sit-ups on the fitness test before deployment reduced the risk.
C1 [Roy, Tanja C.; Piva, Sara R.; Irrgang, James J.] Univ Pittsburgh, Sch Hlth & Rehabil Sci, 4028 Forbes Tower, Pittsburgh, PA 15260 USA.
[Christiansen, Bryan C.] 1st Airborne Brigade Combat Team, Airborne Div 101, 3780 53rd St, Ft Campbell, KY 42223 USA.
[Lesher, Jonathan D.; Doyle, Peter M.] 173rd Airborne Brigade Combat Team, Unit 31401, Box 53, APO, AE 09630 USA.
[Waring, Rachel M.] 2nd Brigade Combat Team, Mt Div 10, 10200 North Riva Ridge Loop, Ft Drum, NY 13602 USA.
[Moore, Charity G.] Univ Pittsburgh, Sch Med, Dept Med, Ctr Res Hlth Care Data Ctr, 200 Meyran Ave,Suite 300, Pittsburgh, PA 15213 USA.
[Brininger, Teresa L.] Med Res & Mat Command, 810 Schreider St, Ft Detrick, MD 21702 USA.
[Sharp, Marilyn A.] US Army, Environm Med Res Inst, 15 Kansas St, Natick, MA 01760 USA.
RP Roy, TC (reprint author), Univ Pittsburgh, Sch Hlth & Rehabil Sci, 4028 Forbes Tower, Pittsburgh, PA 15260 USA.
FU U.S. Army Institute of Environmental Medicine under Task Area S; U.S.
Army Institute of Environmental Medicine
FX The authors acknowledge that this research was performed with funding
from the U.S. Army Institute of Environmental Medicine under Task Area
S. Approved for public release: distribution is unlimited. The authors
would like to thank the Soldiers of the 173rd Airborne Brigade, 1st BCT
101st Airborne Division, and 2nd BCT 10th Mountain Division for their
support and assistance with this study. U.S. Army Institute of
Environmental Medicine funded under Task Area S.
NR 36
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U2 2
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD NOV
PY 2016
VL 181
IS 11
BP E1476
EP E1483
DI 10.7205/MILMED-D-15-00435
PG 8
WC Medicine, General & Internal
SC General & Internal Medicine
GA EL3DS
UT WOS:000394500400005
PM 27849479
ER
PT J
AU Sztuba-Solinska, J
Diaz, L
Kumar, MR
Kolb, G
Wiley, MR
Jozwick, L
Kuhn, JH
Palacios, G
Radoshitzky, SR
Le Grice, SFJ
Johnson, RF
AF Sztuba-Solinska, Joanna
Diaz, Larissa
Kumar, Mia R.
Kolb, Gaelle
Wiley, Michael R.
Jozwick, Lucas
Kuhn, Jens H.
Palacios, Gustavo
Radoshitzky, Sheli R.
Le Grice, Stuart F. J.
Johnson, Reed F.
TI A small stem-loop structure of the Ebola virus trailer is essential for
replication and interacts with heat-shock protein A8
SO NUCLEIC ACIDS RESEARCH
LA English
DT Article
ID SELECTIVE 2'-HYDROXYL ACYLATION; RNA SECONDARY STRUCTURES; SINGLE
NUCLEOTIDE RESOLUTION; PRIMER EXTENSION SHAPE; 3' UNTRANSLATED REGION;
TRACT-BINDING-PROTEIN; MESSENGER-RNA; MARBURG-VIRUS; HOST PROTEIN;
HIGH-THROUGHPUT
AB Ebola virus (EBOV) is a single-stranded negative-sense RNA virus belonging to the Filoviridae family. The leader and trailer non-coding regions of the EBOV genome likely regulate its transcription, replication, and progeny genome packaging. We investigated the cis-acting RNA signals involved in RNA-RNA and RNA-protein interactions that regulate replication of eGFP-encoding EBOV minigenomic RNA and identified heat shock cognate protein family A (HSC70) member 8 (HSPA8) as an EBOV trailer-interacting host protein. Mutational analysis of the trailer HSPA8 binding motif revealed that this interaction is essential for EBOV minigenome replication. Selective 2'-hydroxyl acylation analyzed by primer extension analysis of the secondary structure of the EBOVminigenomic RNA indicates formation of a small stem-loop composed of the HSPA8 motif, a 3'-stem-loop (nucleotides 1868-1890) that is similar to a previously identified structure in the replicative intermediate (RI) RNA and a panhandle domain involving a trailer-to-leader interaction. Results ofminigenome assays and an EBOV reverse genetic system rescue support a role for both the panhandle domain and HSPA8 motif 1 in virus replication.
C1 [Sztuba-Solinska, Joanna; Le Grice, Stuart F. J.] NCI, RT Biochem Sect, Basic Res Lab, NIH, Frederick, MD 21702 USA.
[Diaz, Larissa; Kumar, Mia R.; Kolb, Gaelle; Johnson, Reed F.] NIAID, Emerging Viral Pathogens Sect, NIH, Frederick, MD 21702 USA.
[Wiley, Michael R.; Jozwick, Lucas; Palacios, Gustavo; Radoshitzky, Sheli R.] US Army, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
[Kuhn, Jens H.] NIAID, Integrated Res Facil Ft Detrick, NIH, Frederick, MD 21702 USA.
RP Le Grice, SFJ (reprint author), NCI, RT Biochem Sect, Basic Res Lab, NIH, Frederick, MD 21702 USA.; Johnson, RF (reprint author), NIAID, Emerging Viral Pathogens Sect, NIH, Frederick, MD 21702 USA.
EM legrices@mail.nih.gov; johnsonreed@mail.nih.gov
OI Kuhn, Jens H./0000-0002-7800-6045
FU NIAID Division of Intramural Research; Intramural Research Program of
the National Cancer Institute, National Institutes of Health, Department
of Health and Human Services; Battelle Memorial Institute's prime
contract; US National Institute of Allergy and Infectious Diseases
(NIAID) [HHSN272200700016I]; The Joint Science and Technology Office for
Chemical and Biological Defense (JSTO-CBD) of the Defense Threat
Reduction Agency (DTRA) [1323839, CB3849]; Defense Threat Reduction
Agency [CB10217]
FX This work was supported by the NIAID Division of Intramural Research.
S.L.G. and J.S.-S. were supported by the Intramural Research Program of
the National Cancer Institute, National Institutes of Health, Department
of Health and Human Services. This work was funded in part through
Battelle Memorial Institute's prime contract with the US National
Institute of Allergy and Infectious Diseases (NIAID) under Contract No.
HHSN272200700016I. A subcontractor to Battelle Memorial Institute who
performed this work is: J.H.K. an employee of Tunnell Government
Services, Inc. S.R.R was supported by The Joint Science and Technology
Office for Chemical and Biological Defense (JSTO-CBD) of the Defense
Threat Reduction Agency (DTRA) (proposal #1323839 and CCAR# CB3849).
Portions of this work performed by S.R.R. and L.J. were funded by the
Defense Threat Reduction Agency, CB10217.
NR 68
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U1 2
U2 2
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0305-1048
EI 1362-4962
J9 NUCLEIC ACIDS RES
JI Nucleic Acids Res.
PD NOV
PY 2016
VL 44
IS 20
BP 9831
EP 9846
DI 10.1093/nar/gkw825
PG 16
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA EK3HR
UT WOS:000393817800031
PM 27651462
ER
PT J
AU Wong, T
Collier, S
AF Wong, Thomas
Collier, Sandra
TI Special Issue: Aero-Acoustics for Defence and Security
SO IET RADAR SONAR AND NAVIGATION
LA English
DT Editorial Material
C1 [Wong, Thomas] Johns Hopkins Univ, Appl Phys Lab, Laurel, MD 20723 USA.
[Wong, Thomas] Hong Kong Polytech Univ, Hong Kong, Hong Kong, Peoples R China.
[Collier, Sandra] US Army, Arlington, VA USA.
RP Wong, T (reprint author), Johns Hopkins Univ, Appl Phys Lab, Laurel, MD 20723 USA.; Wong, T (reprint author), Hong Kong Polytech Univ, Hong Kong, Hong Kong, Peoples R China.
NR 0
TC 0
Z9 0
U1 2
U2 2
PU INST ENGINEERING TECHNOLOGY-IET
PI HERTFORD
PA MICHAEL FARADAY HOUSE SIX HILLS WAY STEVENAGE, HERTFORD SG1 2AY, ENGLAND
SN 1751-8784
EI 1751-8792
J9 IET RADAR SONAR NAV
JI IET Radar Sonar Navig.
PD NOV
PY 2016
VL 10
IS 9
SI SI
BP 1517
EP 1518
DI 10.1049/iet-rsn.2016.0560
PG 2
WC Engineering, Electrical & Electronic; Telecommunications
SC Engineering; Telecommunications
GA EJ3HC
UT WOS:000393102200001
ER
PT J
AU Bair, EH
Rittger, K
Davis, RE
Painter, TH
Dozier, J
AF Bair, Edward H.
Rittger, Karl
Davis, Robert E.
Painter, Thomas H.
Dozier, Jeff
TI Validating reconstruction of snow water equivalent in California's
Sierra Nevada using measurements from the NASA Airborne Snow Observatory
SO WATER RESOURCES RESEARCH
LA English
DT Article
ID DATA ASSIMILATION SYSTEM; LANDSAT THEMATIC MAPPER; ENERGY-BALANCE;
SPATIAL-DISTRIBUTION; MOUNTAIN BASINS; RUNOFF MODEL; RIVER-BASIN; COVER
DATA; RADIATION; COLORADO
AB Accurately estimating basin-wide snow water equivalent (SWE) is the most important unsolved problem in mountain hydrology. Models that rely on remotely sensed inputs are especially needed in ranges with few surface measurements. The NASA Airborne Snow Observatory (ASO) provides estimates of SWE at 50 m spatial resolution in several basins across the Western U.S. during the melt season. Primarily, water managers use this information to forecast snowmelt runoff into reservoirs; another impactful use of ASO measurements lies in validating and improving satellite-based snow estimates or models that can scale to whole mountain ranges, even those without ground-based measurements. We compare ASO measurements from 2013 to 2015 to four methods that estimate spatially distributed SWE: two versions of a SWE reconstruction method, spatial interpolation from snow pillows and courses, and NOAA's Snow Data Assimilation System (SNODAS). SWE reconstruction downscales energy forcings to compute potential melt, then multiplies those values by satellite-derived estimates of fractional snow-covered area to calculate snowmelt. The snowpack is then built in reverse from the date the snow is observed to disappear. The two SWE reconstruction models tested include one that employs an energy balance calculation of snowmelt, and one that combines net radiation and degree-day approaches to estimate melt. Our full energy balance model, without ground observations, performed slightly better than spatial interpolation from snow pillows, having no systematic bias and 26% mean absolute error when compared to SWE from ASO. Both reconstruction models and interpolation were more accurate than SNODAS.
C1 [Bair, Edward H.] Univ Calif Santa Barbara, Earth Res Inst, Santa Barbara, CA 93106 USA.
[Rittger, Karl] Natl Snow & Ice Data Ctr, Boulder, CO USA.
[Davis, Robert E.] US Army Corps Engineers, Cold Reg Res & Engn Lab, Hanover, NH USA.
[Painter, Thomas H.] CALTECH, Jet Prop Lab, Pasadena, CA USA.
[Dozier, Jeff] Univ Calif Santa Barbara, Bren Sch Environm Sci & Management, Santa Barbara, CA 93106 USA.
RP Bair, EH (reprint author), Univ Calif Santa Barbara, Earth Res Inst, Santa Barbara, CA 93106 USA.
EM nbair@eri.ucsb.edu
RI Painter, Thomas/B-7806-2016
FU U.S. Army Cold Regions Research and Engineering Laboratory Award
[W913E5-15-C-0003]; NASA [NNH11ZDA001N, NNX12AJ87G]; Microsoft Research
FX We thank Kat Bormann and McKenzie Skiles for supplying ASO snow depth
and SWE measurements at the native 3 m resolution (SWE at 50 m
resolution can be downloaded from http://aso.jpl.nasa.gov/). We thank
Jessica Lundquist, Manuela Girotto, Noah Molotch, and an anonymous
reviewer for their constructive reviews. Support for this work comes
from the U.S. Army Cold Regions Research and Engineering Laboratory
Award W913E5-15-C-0003, NASA Awards NNH11ZDA001N and NNX12AJ87G, and
Microsoft Research. Part of this work was performed at the Jet
Propulsion Laboratory, California Institute of Technology under a
contract with NASA. All data and software used in this study are
available either through the links in the text or upon request. We are
currently working with the UCSB Library on their initiative to serve
data from investigations carried out by researchers on campus.
NR 75
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PU AMER GEOPHYSICAL UNION
PI WASHINGTON
PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA
SN 0043-1397
EI 1944-7973
J9 WATER RESOUR RES
JI Water Resour. Res.
PD NOV
PY 2016
VL 52
IS 11
BP 8437
EP 8460
DI 10.1002/2016WR018704
PG 24
WC Environmental Sciences; Limnology; Water Resources
SC Environmental Sciences & Ecology; Marine & Freshwater Biology; Water
Resources
GA EJ6GY
UT WOS:000393318600003
ER
PT J
AU Schyman, P
Liu, RF
Wallqvist, A
AF Schyman, Patric
Liu, Ruifeng
Wallqvist, Anders
TI Using the Variable-Nearest Neighbor Method To Identify P-Glycoprotein
Substrates and Inhibitors
SO ACS Omega
LA English
DT Article
ID ABC TRANSPORTERS; MODELS; PREDICTION; FINGERPRINTS; TOXICITY; LIGAND
AB Permeability glycoprotein (Pgp) is an essential membrane-bound transporter that efficiently extracts compounds from a cell. As such, it is a critical determinant of the pharmacokinetic properties of drugs. Multidrug resistance in cancer is often associated with overexpression of Pgp, which increases the efflux of chemotherapeutic agents from the cell. This, in turn, may prevent an effective treatment by reducing the effective intracellular concentrations of such agents. Consequently, identifying compounds that can either be transported out of the cell by Pgp (substrates) or impair Pgp function (inhibitors) is of great interest. Herein, using publically available data, we developed quantitative structure-activity relationship (QSAR) models of Pgp substrates and inhibitors. These models employed a variable-nearest neighbor (v-NN) method that calculated the structural similarity between molecules and hence possessed an applicability domain, that is, they used all nearest neighbors that met a minimum similarity constraint. The performance characteristics of these v-NN-based models were comparable or at times superior to those of other model constructs. The best v-NN models for identifying either Pgp substrates or inhibitors showed overall accuracies of >80% and kappa values of >0.60 when tested on external data sets with candidate Pgp substrates and inhibitors. The v-NN prediction model with a well-defined applicability domain gave accurate and reliable results. The v-NN method is computationally efficient and requires no retraining of the prediction model when new assay information becomes available-an important feature when keeping QSAR models up-to-date and maintaining their performance at high levels.
C1 [Schyman, Patric; Liu, Ruifeng; Wallqvist, Anders] US Army, Med Res & Mat Command, Telemed & Adv Technol Res Ctr, DoD Biotechnol High Performance Comp Software App, Ft Detrick, MD 21702 USA.
RP Schyman, P; Wallqvist, A (reprint author), US Army, Med Res & Mat Command, Telemed & Adv Technol Res Ctr, DoD Biotechnol High Performance Comp Software App, Ft Detrick, MD 21702 USA.
EM pschyman@bhsai.org; sven.a.wallqvist.civ@mail.mil
FU US Army Medical Research and Materiel Command (Fort Detrick, MD);
Defense Threat Reduction Agency grant [CBCall14-CBS-05-2-0007]
FX The authors were supported by the US Army Medical Research and Materiel
Command (Fort Detrick, MD) and the Defense Threat Reduction Agency grant
CBCall14-CBS-05-2-0007.
NR 30
TC 0
Z9 0
U1 0
U2 0
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 2470-1343
J9 ACS OMEGA
JI ACS Omega
PD NOV
PY 2016
VL 1
IS 5
BP 923
EP 929
DI 10.1021/acsomega.6b00247
PG 7
WC Chemistry, Multidisciplinary
SC Chemistry
GA EI7XZ
UT WOS:000392719300022
ER
PT J
AU Teyhen, DS
Rhon, DI
Butler, RJ
Shaffer, SW
Goffar, SL
McMillian, DJ
Boyles, RE
Kiesel, KB
Plisky, PJ
AF Teyhen, Deydre S.
Rhon, Daniel I.
Butler, Robert J.
Shaffer, Scott W.
Goffar, Stephen L.
McMillian, Danny J.
Boyles, Robert E.
Kiesel, Kyle B.
Plisky, Phillip J.
TI Association of Physical Inactivity, Weight, Smoking, and Prior Injury on
Physical Performance in a Military Setting
SO JOURNAL OF ATHLETIC TRAINING
LA English
DT Article
DE functional movement; health; injury prediction; risk factors
ID LOWER-EXTREMITY INJURY; MALE SOCCER PLAYERS; BODY-MASS INDEX;
RISK-FACTORS; FUNCTIONAL MOVEMENT; PREVENTION; ADULTS; EPIDEMIOLOGY;
FLEXIBILITY; PREDICTOR
AB Context: Although inactivity, being overweight, smoking, and a history of injury are identified as risk factors for poor health and injury, few authors have examined their association on physical performance. Young adults may be more likely to adopt healthier lifestyles if they understand the effect of health behaviors on performance.
Objective: To determine the association of being overweight, smoking, inactivity, and a history of injury with physical performance.
Design: Cross-sectional study.
Setting: Military population.
Patients or Other Participants: Active-duty service members (N = 1466; 1380 men, 86 women; age = 24.7 +/- 5.0 years; body mass index = 26.7 +/- 3.4 kg/m(2)).
Main Outcome Measure(s): Participants performed 8 measures (the triple-crossover hop for distance, the 6-m timed-hop test, the Functional Movement Screen, the Lower Quarter Y-Balance Test, the Upper Quarter Y-Balance Test, and the 3-event Army Physical Fitness Test) for evaluation of endurance, strength, muscular endurance, power, agility, balance, and motor control. Participants were categorized based on the number of health risk factors present. Using an analysis of covariance, we assessed the relationship between risk factors and physical performance with age and sex as covariates.
Results: Compared with those who had no risk factors (27.9% of men, 34.9% of women), physical performance was worse in those who had 1, 2, or 3 to 4 risk factors present by 4.3%, 6.7%, and 10.3%, respectively. Decrements in performance for those with 3 to 4 risk factors ranged from 3.3% to 14.4%.
Conclusions: An unhealthy lifestyle habit or a history of injury was negatively associated with physical performance. Physical performance decrements were associated with the number of risk factors present. Understanding how risk factors contribute to decreased physical performance may enable clinicians to improve compliance with injury-prevention programs in occupational settings in which a young and relatively healthy workforce may be more concerned about performance than health.
C1 [Teyhen, Deydre S.] US Army, Med Command, Def Hlth Headquarters, Falls Church, VA USA.
[Teyhen, Deydre S.; Rhon, Daniel I.; Shaffer, Scott W.; Goffar, Stephen L.] Baylor Univ, US Army, Doctoral Program Phys Therapy, Joint Base San Antonio, 3599 Winfield Scott Rd, Ft Sam Houston, TX 78234 USA.
[Rhon, Daniel I.] Joint Base Lewis, Madigan Army Med Ctr, Dept Phys Med & Rehabil, Mcchord, WA USA.
[Butler, Robert J.] Duke Univ, Doctoral Program Phys Therapy, Durham, NC USA.
[Goffar, Stephen L.] Univ Incarnate Word, Sch Phys Therapy, San Antonio, TX USA.
[McMillian, Danny J.; Boyles, Robert E.] Univ Puget Sound, Doctoral Program Phys Therapy, Tacoma, WA 98416 USA.
[Kiesel, Kyle B.; Plisky, Phillip J.] Univ Evansville, Doctoral Program Phys Therapy, Evansville, IN 47722 USA.
[Kiesel, Kyle B.; Plisky, Phillip J.] ProRehab PC, Evansville, IN USA.
RP Teyhen, DS (reprint author), Baylor Univ, US Army, Doctoral Program Phys Therapy, Joint Base San Antonio, 3599 Winfield Scott Rd, Ft Sam Houston, TX 78234 USA.
EM deydre.s.teyhen.mil@mail.mil
FU MRMC, Army Medical Department Advanced Medical Technology Initiative;
TATRC, Military Operational Medicine Research Program; Defense Medical
Research and Development Program
FX This research trial was supported by the MRMC, Army Medical Department
Advanced Medical Technology Initiative, TATRC, Military Operational
Medicine Research Program, and Defense Medical Research and Development
Program.
NR 30
TC 0
Z9 0
U1 3
U2 3
PU NATL ATHLETIC TRAINERS ASSOC INC
PI DALLAS
PA 2952 STEMMONS FREEWAY, DALLAS, TX 75247 USA
SN 1062-6050
EI 1938-162X
J9 J ATHL TRAINING
JI J. Athl. Train.
PD NOV
PY 2016
VL 51
IS 11
BP 866
EP 875
DI 10.4085/1062-6050-51.6.02
PG 10
WC Sport Sciences
SC Sport Sciences
GA EI9WZ
UT WOS:000392861400005
PM 27690529
ER
PT J
AU Carow, SD
Haniuk, EM
Cameron, KL
Padua, DA
Marshall, SW
DiStefano, LJ
de la Motte, SJ
Beutler, AI
Gerber, JP
AF Carow, Scott D.
Haniuk, Eric M.
Cameron, Kenneth L.
Padua, Darin A.
Marshall, Stephen W.
DiStefano, Lindsay J.
de la Motte, Sarah J.
Beutler, Anthony I.
Gerber, John P.
TI Risk of Lower Extremity Injury in a Military Cadet Population After a
Supervised Injury-Prevention Program
SO JOURNAL OF ATHLETIC TRAINING
LA English
DT Article
DE warm-ups; exercises; Dynamic Integrated Movement Enhancement
ID CRUCIATE LIGAMENT INJURIES; RANDOMIZED CONTROLLED-TRIAL; SOCCER PLAYERS;
JUMP-ACL; ANKLE SPRAIN; FEMALE; EPIDEMIOLOGY; SPORTS; INTERVENTION;
BIOMECHANICS
AB Context: Specific movement patterns have been identified as possible risk factors for noncontact lower extremity injuries. The Dynamic Integrated Movement Enhancement (DIME) was developed to modify these movement patterns to decrease injury risk.
Objective: To determine if the DIME is effective for preventing lower extremity injuries in US Military Academy (USMA) cadets.
Design: Cluster-randomized controlled trial.
Setting: Cadet Basic Training at USMA.
Patients or Other Participants: Participants were 1313 cadets (1070 men, 243 women).
Intervention(s): Participants were cluster randomized to 3 groups. The active warm-up (AWU) group performed standard Army warm-up exercises. The DIME groups were assigned to a DIME cadre-supervised (DCS) group or a DIME expert-supervised (DES) group; the former consisted of cadet supervision and the latter combined cadet and health professional supervision. Groups performed exercises 3 times weekly for 6 weeks.
Main Outcome Measure(s): Cumulative risk of lower extremity injury was the primary outcome. We gathered data during Cadet Basic Training and for 9 months during the subsequent academic year. Risk ratios and 95% confidence intervals (CIs) were calculated to compare groups.
Results: No differences were seen between the AWU and the combined DIME (DCS and DES) groups during Cadet Basic Training or the academic year. During the academic year, lower extremity injury risk in the DES group decreased 41% (relative risk [RR] = 0.59; 95% CI = 0.38, 0.93; P = .02) compared with the DCS group; a nonsignificant 25% (RR = 0.75; 95% CI = 0.49, 1.14; P = .18) decrease occurred in the DES group compared with the AWU group. Finally, there was a nonsignificant 27% (RR = 1.27; 95% CI = 0.90, 1.78; P = .17) increase in injury risk during the academic year in the DCS group compared with the AWU group.
Conclusions: We observed no differences in lower extremity injury risk between the AWU and combined DIME groups. However, the magnitude and direction of the risk ratios in the DES group compared with the AWU group, although not statistically significant, indicate that professional supervision may be a factor in the success of injury-prevention programs.
C1 [Carow, Scott D.] William Beaumont Army Med Ctr, 5005 North Piedras St, El Paso, TX 79920 USA.
[Haniuk, Eric M.; Cameron, Kenneth L.] Keller Army Community Hosp, John A Feagin Sports Med Fellowship, West Point, NY USA.
[Padua, Darin A.; Marshall, Stephen W.] Univ N Carolina, Chapel Hill, NC USA.
[DiStefano, Lindsay J.] Univ Connecticut, Storrs, CT USA.
[de la Motte, Sarah J.; Beutler, Anthony I.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
[Gerber, John P.] Womack Army Med Ctr, Ft Bragg, NC USA.
RP Carow, SD (reprint author), William Beaumont Army Med Ctr, 5005 North Piedras St, El Paso, TX 79920 USA.
EM scott.carow@gmail.com
OI Cameron, Kenneth/0000-0002-6276-4482
NR 28
TC 0
Z9 0
U1 2
U2 2
PU NATL ATHLETIC TRAINERS ASSOC INC
PI DALLAS
PA 2952 STEMMONS FREEWAY, DALLAS, TX 75247 USA
SN 1062-6050
EI 1938-162X
J9 J ATHL TRAINING
JI J. Athl. Train.
PD NOV
PY 2016
VL 51
IS 11
BP 905
EP 918
DI 10.4085/1062-6050-49.5.22
PG 14
WC Sport Sciences
SC Sport Sciences
GA EI9WZ
UT WOS:000392861400010
PM 25117875
ER
PT J
AU Cameron, KL
Driban, JB
Svoboda, SJ
AF Cameron, Kenneth L.
Driban, Jeffrey B.
Svoboda, Steven J.
TI Osteoarthritis and the Tactical Athlete: A Systematic Review
SO JOURNAL OF ATHLETIC TRAINING
LA English
DT Review
DE epidemiology; military; fire fighters; police; law enforcement; first
responders
ID ANTERIOR CRUCIATE LIGAMENT; MILITARY SERVICE MEMBERS;
PHYSICIAN-DIAGNOSED OSTEOARTHRITIS; LOWER-LIMB FUNCTION; KNEE
OSTEOARTHRITIS; UNITED-STATES; RISK-FACTORS; HIP OSTEOARTHRITIS; US
MILITARY; POSTTRAUMATIC OSTEOARTHRITIS
AB Objective: Although tactical athletes (eg, military service members, law enforcement personnel, fire fighters) are exposed to several known risk factors, it remains unclear if they are at increased risk for osteoarthritis (OA). The purpose of this systematic review was to investigate the association between serving as a tactical athlete and the incidence and prevalence of OA.
Data Sources: We completed a comprehensive systematic literature search in November 2014 using 12 bibliographic databases (eg, PubMed, Ovid, SportDiscus) supplemented with manual searches of reference lists.
Study Selection: Studies were included if they met the following criteria: (1) an aim of the study was to investigate an association between tactical athletes and OA; (2) the outcome measure was radiographic OA, clinical OA, total joint replacement, self-reported diagnosis of OA, or placement on a waiting list for a total joint replacement; (3) the study design was a cohort study; and (4) the study was written in English.
Data Extraction: One investigator extracted data from articles that met all inclusion criteria (eg, group descriptions, measures of disease burden, source of nonexposed controls).
Data Synthesis: Twelve articles met the inclusion criteria and described retrospective cohort studies. Firefighters, activeduty military service members, and veteran military parachutists consistently had a higher incidence or prevalence of knee, hip, or any OA diagnosis (4 studies). Active-duty pilots and veteran military parachutists may have a higher prevalence of spine OA, but this was not statistically significant (2 studies). Occupational risk factors for OA among tactical athletes include rank and branch of military service. The risk of OA among individuals who completed mandatory national military service remains unclear (6 studies).
Conclusions: The incidence of OA among tactical athletes appears to be significantly higher when compared with nonexposed controls. Further research is needed to specifically identify modifiable risk factors within this high-risk population to develop and implement effective risk-reduction strategies.
C1 [Cameron, Kenneth L.; Svoboda, Steven J.] Keller Army Hosp, West Point, NY USA.
[Driban, Jeffrey B.] Tufts Med Ctr, Boston, MA USA.
RP Cameron, KL (reprint author), Keller Army Hosp, John A Feagin Jr Sports Med Fellowship, 900 Washington Rd, West Point, NY 10996 USA.
EM kenneth.l.cameron.civ@mail.mil
NR 61
TC 0
Z9 0
U1 0
U2 0
PU NATL ATHLETIC TRAINERS ASSOC INC
PI DALLAS
PA 2952 STEMMONS FREEWAY, DALLAS, TX 75247 USA
SN 1062-6050
EI 1938-162X
J9 J ATHL TRAINING
JI J. Athl. Train.
PD NOV
PY 2016
VL 51
IS 11
BP 952
EP 961
DI 10.4085/1062-6050-51.5.03
PG 10
WC Sport Sciences
SC Sport Sciences
GA EI9WZ
UT WOS:000392861400015
PM 27115044
ER
PT J
AU Knapik, J
Steelman, R
AF Knapik, Joseph
Steelman, Ryan
TI Risk Factors for Injuries During Military Static-Line Airborne
Operations: A Systematic Review and Meta-Analysis
SO JOURNAL OF ATHLETIC TRAINING
LA English
DT Review
DE parachutes; parachuting; wind speed; night; temperature; parachute ankle
brace; terrain; wounds; trauma; musculoskeletal
ID PARACHUTE LANDING INJURIES; ANKLE BRACE; PHYSICAL-FITNESS; US ARMY;
FEMALE; RATES; SURVEILLANCE; REDUCTION; BATTALION; ALTITUDE
AB Objective: To identify and analyze articles in which the authors examined risk factors for soldiers during military staticline airborne operations.
Data Sources: We searched for articles in PubMed, the Defense Technical Information Center, reference lists, and other sources using the key words airborne, parachuting, parachutes, paratrooper, injuries, wounds, trauma, and musculoskeletal.
Study Selection: The search identified 17 684 potential studies. Studies were included if they were written in English, involved military static-line parachute operations, recorded injuries directly from events on the landing zone or from safety or medical records, and provided data for quantitative assessment of injury risk factors. A total of 23 studies met the review criteria, and 15 were included in the meta-analysis.
Data Extraction: The summary statistic obtained for each risk factor was the risk ratio, which was the ratio of the injury risk in 1 group to that of another (baseline) group. Where data were sufficient, meta-analyses were performed and heterogeneity and publication bias were assessed.
Data Synthesis: Risk factors for static-line parachuting injuries included night jumps, jumps with extra equipment, higher wind speeds, higher air temperatures, jumps from fixedwing aircraft rather than balloons or helicopters, jumps onto certain types of terrain, being a female paratrooper, greater body weight, not using the parachute ankle brace, smaller parachute canopies, simultaneous exits from both sides of an aircraft, higher heat index, winds from the rear of the aircraft on exit entanglements, less experience with a particular parachute system, being an enlisted soldier rather than an officer, and jumps involving a greater number of paratroopers.
Conclusions: We analyzed and summarized factors that increased the injury risk for soldiers during military static-line parachute operations. Understanding and considering these factors in risk evaluations may reduce the likelihood of injury during parachuting.
C1 [Knapik, Joseph; Steelman, Ryan] US Army, Portfolio Epidemiol & Dis Surveillance, Publ Hlth Ctr, 5154 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA.
[Knapik, Joseph] Oak Ridge Inst Sci & Educ, Aberdeen Proving Ground, MD USA.
RP Knapik, J (reprint author), US Army, Portfolio Epidemiol & Dis Surveillance, Publ Hlth Ctr, 5154 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA.
EM joseph.j.knapik.ctr@mail.mil
NR 67
TC 0
Z9 0
U1 0
U2 0
PU NATL ATHLETIC TRAINERS ASSOC INC
PI DALLAS
PA 2952 STEMMONS FREEWAY, DALLAS, TX 75247 USA
SN 1062-6050
EI 1938-162X
J9 J ATHL TRAINING
JI J. Athl. Train.
PD NOV
PY 2016
VL 51
IS 11
BP 962
EP 980
DI 10.4085/1062-6050-51.9.10
PG 19
WC Sport Sciences
SC Sport Sciences
GA EI9WZ
UT WOS:000392861400016
PM 28068166
ER
PT J
AU Lee, KM
Ballard, MS
McNeese, AR
Muir, TG
Wilson, PS
Costley, RD
Hathaway, KK
AF Lee, Kevin M.
Ballard, Megan S.
McNeese, Andrew R.
Muir, Thomas G.
Wilson, Preston S.
Costley, R. Daniel
Hathaway, Kent K.
TI In situ measurements of sediment acoustic properties in Currituck Sound
and comparison to models
SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
LA English
DT Article
ID SHEAR-WAVE ATTENUATION; MARINE-SEDIMENTS; VELOCITY DISPERSION; NATURAL
MATERIALS; FREQUENCY RANGE; NORTH-CAROLINA; ELASTIC WAVES; GLASS-BEADS;
PROPAGATION; SAND
AB In situ measurements of compressional and shear wave speed and attenuation were collected 30 cm below the water-sediment interface in Currituck Sound, North Carolina at two field locations having distinctly different sediment types: medium-to-fine-grained sand and fine-grained sand with approximately 10% mud content. Shear wave measurements were performed with bimorph transducers to generate and receive horizontally polarized shear waves in the 300 Hz to 1 kHz band, and compressional wave measurements were performed using hydrophones operated in the 5 kHz to 100 kHz band. Sediment samples were collected at both measurement sites and later analyzed in the laboratory to characterize the sediment grain size distribution for each field location. Compressional and shear wave speed and attenuation were estimated from the acoustic measurements, and preliminary comparisons to the extended Biot model by Chotiros and Isakson [J. Acoust. Soc. 135, 3264-3279 (2014)] and the viscous grain-shearing theory by Buckingham [J. Acoust. Soc. 136, 2478-2488 (2014)] were performed. (C) 2016 Acoustical Society of America.
C1 [Lee, Kevin M.; Ballard, Megan S.; McNeese, Andrew R.; Muir, Thomas G.; Wilson, Preston S.] Univ Texas Austin, Appl Res Labs, POB 8029, Austin, TX 78713 USA.
[Costley, R. Daniel] US Army, Engineer Res & Dev Ctr, Geotech & Struct Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
[Hathaway, Kent K.] US Army, Corps Engineers, Field Res Facil, Coastal & Hydraul Lab, 1261 Duck Rd, Kitty Hawk, NC 27949 USA.
[Wilson, Preston S.] Univ Texas Austin, Dept Mech Engn, 1 Univ Stn C2200, Austin, TX 78712 USA.
RP Lee, KM (reprint author), Univ Texas Austin, Appl Res Labs, POB 8029, Austin, TX 78713 USA.
EM klee@arlut.utexas.edu
FU U.S. Army Engineer Research and Development Center (Vicksburg, MS); U.S.
Navy Office of Naval Research Ocean Acoustics and Ocean Engineering
Programs; ARL:UT Independent Research and Development Program
FX This work was supported by the U.S. Army Engineer Research and
Development Center (Vicksburg, MS), the U.S. Navy Office of Naval
Research Ocean Acoustics and Ocean Engineering Programs, and the ARL:UT
Independent Research and Development Program. The authors also thank the
support crew at the U.S. Army Corps of Engineers Field Research Facility
(Duck, NC), Matthew Kryder and Jeremy King at ARL:UT for assisting with
the laboratory measurements, Dan Duncan of the University of Texas at
Austin Institute for Geophysics for assistance with grain size analysis,
and Michael J. Buckingham, Nicholas P. Chotiros, Marcia J. Isakson, and
Anthony L. Bonomo for helpful discussions concerning implementation of
their respective sediment acoustics models.
NR 46
TC 0
Z9 0
U1 2
U2 2
PU ACOUSTICAL SOC AMER AMER INST PHYSICS
PI MELVILLE
PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA
SN 0001-4966
EI 1520-8524
J9 J ACOUST SOC AM
JI J. Acoust. Soc. Am.
PD NOV
PY 2016
VL 140
IS 5
BP 3593
EP 3606
DI 10.1121/1.4966118
PG 14
WC Acoustics; Audiology & Speech-Language Pathology
SC Acoustics; Audiology & Speech-Language Pathology
GA EH3YJ
UT WOS:000391707700027
PM 27908029
ER
PT J
AU Kan, A
Jones, HG
Litovsky, RY
AF Kan, Alan
Jones, Heath G.
Litovsky, Ruth Y.
TI Lateralization of interaural timing differences with multi-electrode
stimulation in bilateral cochlear-implant users
SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
LA English
DT Article
ID SOUND LOCALIZATION; TIME DIFFERENCES; HEARING; SENSITIVITY; LISTENERS
AB Bilateral cochlear implant (BiCI) users have shown variability in interaural time difference (ITD) sensitivity at different places along the cochlea. This paper investigates perception of multi-electrode binaural stimulation to determine if auditory object formation (AOF) and lateralization are affected by variability in ITD sensitivity when a complex sound is encoded with multi-channel processing. AOF and ITD lateralization were compared between single-and multi-electrode configurations. Most (7/8) BiCI users perceived a single auditory object with multi-electrode stimulation, and the range of lateralization was comparable to single-electrode stimulation, suggesting that variability in single-electrode ITD sensitivity does not compromise AOF with multi-electrode stimulation. (C) 2016 Acoustical Society of America
C1 [Kan, Alan; Litovsky, Ruth Y.] Univ Wisconsin Madison, Waisman Ctr, Binaural Hearing & Speech Lab, 1500 Highland Ave, Madison, WI 53705 USA.
[Jones, Heath G.] US Army, Aeromed Res Lab, Auditory Protect & Performance Div, Bldg 6901,Farrel Rd, Ft Rucker, AL 36362 USA.
RP Kan, A (reprint author), Univ Wisconsin Madison, Waisman Ctr, Binaural Hearing & Speech Lab, 1500 Highland Ave, Madison, WI 53705 USA.
EM ahkan@waisman.wisc.edu; heath.g.jones2.ctr@mail.mil;
litovsky@waisman.wisc.edu
FU NIH-NIDCD [R03-DC015321, R01-DC003083]; NIH-NICHD [P30-HD03352]
FX We would like to thank our research participants who traveled to Madison
to participate in these experiments. We would also like to thank
Cochlear Ltd., in particular, Zachary Smith and Aaron Parkinson, for
providing the research hardware and technical support. This study was
supported by funding from the NIH-NIDCD (Grant No. R03-DC015321 to A.K.
and Grant No. R01-DC003083 to R.Y.L.) and in part by a core grant from
the NIH-NICHD (Grant No. P30-HD03352 to Waisman Center).
NR 16
TC 0
Z9 0
U1 0
U2 0
PU ACOUSTICAL SOC AMER AMER INST PHYSICS
PI MELVILLE
PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA
SN 0001-4966
EI 1520-8524
J9 J ACOUST SOC AM
JI J. Acoust. Soc. Am.
PD NOV
PY 2016
VL 140
IS 5
BP EL392
EP EL398
DI 10.1121/1.4967014
PG 7
WC Acoustics; Audiology & Speech-Language Pathology
SC Acoustics; Audiology & Speech-Language Pathology
GA EH3YJ
UT WOS:000391707700004
PM 27908067
ER
PT J
AU Rosen, G
Wild, B
George, RD
Belden, JB
Lotufo, GR
AF Rosen, Gunther
Wild, Bill
George, Robert D.
Belden, Jason B.
Lotufo, Guilherme R.
TI Optimization and Field Demonstration of a Passive Sampling Technology
for Monitoring Conventional Munition Constituents in Aquatic
Environments
SO MARINE TECHNOLOGY SOCIETY JOURNAL
LA English
DT Article
DE passive sampling; munitions; POCIS; TNT; RDX
ID INTEGRATIVE SAMPLER; COMPOSITION-B; POCIS; CALIBRATION; TRANSPORT;
ORDNANCE; FATE
AB As a result of military training and weapon testing activities, unexploded ordnance (UXO; including munitions such as bombs, projectiles, and mines that did not function as intended) are present in underwater environments. Munitions are also present at underwater sites as discarded military munitions (DMM). In addition to explosive safety considerations, regulators are increasingly concerned about potential ecological impacts on the aquatic environment following corrosion and breaching shells that may cause the slow release of the explosive material by dissolution to the surrounding sediments and water column. Challenges such as the high level of effort required to identify leaking munitions and potential for slow and intermittent release resulting in ultralow concentrations (i.e., part per trillion) may hinder the assessment of environmental exposures using traditional water sampling and analysis techniques. Recently, integrative passive samplers, specifically polar organic chemical integrative samplers (POCIS), have been demonstrated by our team to be valuable tools for the environmental exposure assessment of munition constituents (MC) in aquatic environments. POCIS can be deployed for weeks to months and continuously sample the water, providing the opportunity to capture episodic events or fluctuations in contaminant release, even at low concentrations. The resulting time-weighted average (TWA) water concentration can then be compared with screening values in the context of ecological risk potential and relevance for remedial action. Our preliminary results from POCIS employed under field conditions indicate that it is a robust approach to understanding and validating the release and transport behaviors of MC and subsequent exposure characterization in the vicinity of potentially breached UXO or DMM in ocean environments.
C1 [Rosen, Gunther; Wild, Bill; George, Robert D.] Space & Naval Warfare Syst Ctr Pacific, 53475 Strothe Rd, San Diego, CA 92152 USA.
[Belden, Jason B.] Oklahoma State Univ, Stillwater, OK 74078 USA.
[Lotufo, Guilherme R.] US Army, ERDC, Vicksburg, MS USA.
RP Rosen, G (reprint author), Space & Naval Warfare Syst Ctr Pacific, 53475 Strothe Rd, San Diego, CA 92152 USA.
EM rosen@spawar.navy.mil
FU U.S. Department of Defense's Environmental Security Technology
Certification Program (ESTCP) [ER-201433]; U.S. Navy's Environmental
Sustainability Development to Integration (NESDI) Program [465]
FX This work was funded by the U.S. Department of Defense's Environmental
Security Technology Certification Program (ESTCP; Project #ER-201433)
and the U.S. Navy's Environmental Sustainability Development to
Integration (NESDI) Program (Project #465). The following, and many
others, have been instrumental for various portions of this research:
Dr. Dan Waddill and Mr. Kevin Cloe (NAVFAC Atlantic); CH2M Hill
Munitions Response and Scientific Dive teams; Dr. Mace Barron, Dr.
Morgan Willming, and Mr. Jason Mangum (USEPA GED); Dr. Stephen Fallis
and Mr. Gregory Ostrom (Naval Air Weapons Station China Lake); Ms. Diane
Wehner (NOAA Office of Response and Restoration); Ms. Kristal Sieve and
Dr. Shane Morrison (Oklahoma State University); Mr. James Biedenbach,
Dr. David Smith, Dr. Christa Woodley, Mr. Bryton Hixon, Mr. Charles
Perneciario, and Ms. Sally Davis (USACE ERDC); and Ms. Marienne Colvin,
Mr. Joel Guerrero, Mr. Patrick Earley, and Dr. Bart Chadwick (SSC
Pacific).
NR 27
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PU MARINE TECHNOLOGY SOC INC
PI COLUMBIA
PA 5565 STERRETT PLACE, STE 108, COLUMBIA, MD 21044 USA
SN 0025-3324
EI 1948-1209
J9 MAR TECHNOL SOC J
JI Mar. Technol. Soc. J.
PD NOV-DEC
PY 2016
VL 50
IS 6
BP 23
EP 32
PG 10
WC Engineering, Ocean; Oceanography
SC Engineering; Oceanography
GA EG9BB
UT WOS:000391350900006
ER
PT J
AU Yeh, FC
Vettel, JM
Singh, A
Poczos, B
Grafton, ST
Erickson, KI
Tseng, WYI
Verstynen, TD
AF Yeh, Fang-Cheng
Vettel, Jean M.
Singh, Aarti
Poczos, Barnabas
Grafton, Scott T.
Erickson, Kirk I.
Tseng, Wen-Yih I.
Verstynen, Timothy D.
TI Quantifying Differences and Similarities in Whole-Brain White Matter
Architecture Using Local Connectome Fingerprints
SO PLOS COMPUTATIONAL BIOLOGY
LA English
DT Article
ID DIFFUSION MRI; INTELLECTUAL-PERFORMANCE; CORPUS-CALLOSUM; CONNECTIVITY;
HERITABILITY; MICROSTRUCTURE; DEMYELINATION; TRACTOGRAPHY; ANISOTROPY;
NETWORKS
AB Quantifying differences or similarities in connectomes has been a challenge due to the immense complexity of global brain networks. Here we introduce a noninvasive method that uses diffusion MRI to characterize whole-brain white matter architecture as a single local connectome fingerprint that allows for a direct comparison between structural connectomes. In four independently acquired data sets with repeated scans (total N = 213), we show that the local connectome fingerprint is highly specific to an individual, allowing for an accurate self-versus-others classification that achieved 100% accuracy across 17,398 identification tests. The estimated classification error was approximately one thousand times smaller than fingerprints derived from diffusivity-based measures or region-to-region connectivity patterns for repeat scans acquired within 3 months. The local connectome fingerprint also revealed neuroplasticity within an individual reflected as a decreasing trend in self-similarity across time, whereas this change was not observed in the diffusivity measures. Moreover, the local connectome fingerprint can be used as a phenotypic marker, revealing 12.51% similarity between monozygotic twins, 5.14% between dizygotic twins, and 4.51% between none-twin siblings, relative to differences between unrelated subjects. This novel approach opens a new door for probing the influence of pathological, genetic, social, or environmental factors on the unique configuration of the human connectome.
C1 [Yeh, Fang-Cheng] Univ Pittsburgh, Sch Med, Dept Neurol Surg, Pittsburgh, PA 15261 USA.
[Vettel, Jean M.] US Army Res Lab, Aberdeen, MD USA.
[Vettel, Jean M.; Grafton, Scott T.] Univ Calif Santa Barbara, Dept Psychol & Brain Sci, Santa Barbara, CA 93106 USA.
[Vettel, Jean M.] Univ Penn, Dept Bioengn, Philadelphia, PA 19104 USA.
[Singh, Aarti; Poczos, Barnabas] Carnegie Mellon Univ, Dept Machine Learning, Pittsburgh, PA 15213 USA.
[Erickson, Kirk I.] Univ Pittsburgh, Dept Psychol, Pittsburgh, PA 15260 USA.
[Tseng, Wen-Yih I.] Natl Taiwan Univ, Inst Med Device & Imaging, Taipei, Taiwan.
[Tseng, Wen-Yih I.] Natl Taiwan Univ, Mol Imaging Ctr, Taipei, Taiwan.
[Verstynen, Timothy D.] Carnegie Mellon Univ, Dept Psychol, Pittsburgh, PA 15213 USA.
[Verstynen, Timothy D.] Carnegie Mellon Univ, Ctr Neural Basis Cognit, Pittsburgh, PA 15213 USA.
RP Yeh, FC (reprint author), Univ Pittsburgh, Sch Med, Dept Neurol Surg, Pittsburgh, PA 15261 USA.; Verstynen, TD (reprint author), Carnegie Mellon Univ, Dept Psychol, Pittsburgh, PA 15213 USA.; Verstynen, TD (reprint author), Carnegie Mellon Univ, Ctr Neural Basis Cognit, Pittsburgh, PA 15213 USA.
EM frank.yeh@pitt.edu; timothyv@andrew.cmu.edu
OI Yeh, Fang-Cheng/0000-0002-7946-2173; Grafton, Scott/0000-0003-4015-3151
FU Army Research Laboratory; NSF BIGDATA [1247658]; Human Connectome
Project, WU-Minn Consortium [1U54MH091657]; Ruentex Group; Ministry of
Economic Affairs, Taiwan [101-EC-17-A-19-S1-175]; National Institutes of
Health [R01 DK095172]; [W911NF-10-2-0022]
FX The research was sponsored by the Army Research Laboratory and
accomplished under Cooperative Agreement Number W911NF-10-2-0022. The
views and conclusions contained in this document are those of the
authors and should not be interpreted as representing the official
policies, either expressed or implied, of the Army Research Laboratory
or the U.S. Government. This research was supported by and NSF BIGDATA
(1247658). Part of the data used this study were from the Human
Connectome Project, WU-Minn Consortium (1U54MH091657). This research was
supported in part by the Ruentex Group and the Ministry of Economic
Affairs, Taiwan (101-EC-17-A-19-S1-175). This research was supported in
part by National Institutes of Health (R01 DK095172). The funders had no
role in study design, data collection and analysis, decision to publish,
or preparation of the manuscript.
NR 41
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PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1553-734X
EI 1553-7358
J9 PLOS COMPUT BIOL
JI PLoS Comput. Biol.
PD NOV
PY 2016
VL 12
IS 11
AR e1005203
DI 10.1371/journal.pcbi.1005203
PG 17
WC Biochemical Research Methods; Mathematical & Computational Biology
SC Biochemistry & Molecular Biology; Mathematical & Computational Biology
GA EG7MC
UT WOS:000391230900034
PM 27846212
ER
PT J
AU Smith, L
Westrick, R
Sauers, S
Cooper, A
Scofield, D
Claro, P
Warr, B
AF Smith, Laurel
Westrick, Richard
Sauers, Sarah
Cooper, Adam
Scofield, Dennis
Claro, Pedro
Warr, Bradley
TI Underreporting of Musculoskeletal Injuries in the US Army: Findings From
an Infantry Brigade Combat Team Survey Study
SO SPORTS HEALTH-A MULTIDISCIPLINARY APPROACH
LA English
DT Article
DE musculoskeletal injury; injury reporting; military readiness; injury
exaggeration
ID OPERATIONS IRAQI FREEDOM; OCCUPATIONAL INJURY; ENDURING FREEDOM;
MILITARY; SURVEILLANCE; PREVENTION; ILLNESS; RECOMMENDATIONS;
DISABILITIES; AFGHANISTAN
AB Background: Musculoskeletal injury is a significant threat to readiness in the US Army. Current injury surveillance methods are constrained by accurate injury reporting. Input into electronic medical records or databases therefore may not accurately reflect injury incidence. The purpose of this study was to evaluate injury reporting among active-duty US Army soldiers to explore potential limitations of surveillance approaches.
Hypothesis: A significant number of injuries go unreported to medical personnel.
Study Design: Cross-sectional study.
Level of Evidence: Level 4.
Methods: Surveys were completed by soldiers assigned to an Army Infantry Brigade Combat Team. Survey questions inquired about injuries sustained in the previous 12 months, injury onset, and whether injuries were reported to a medical provider. Participants were asked to rank reasons for accurately reporting, underreporting, and/or exaggerating injuries. Chi-square analyses were used to compare differences among underreported injuries in terms of injury onset (gradual vs acute) and sex.
Results: A total of 1388 soldiers reported 3202 injuries that had occurred in the previous 12-month period, including 1636 (51%) that were reported and 1566 (49%) that were identified as not reported to medical personnel. More than 49% of reported injuries were described as acute and 51% were described as chronic. Injury exaggeration was reported by 6% of soldiers. The most common reasons for not reporting injuries were fear that an injury might affect future career opportunities and avoidance of military "profiles" (mandated physical restrictions).
Conclusion: Approximately half of musculoskeletal injuries in a Brigade Combat Team were not reported.
Clinical Relevance: Unreported and untreated injuries can lead to reinjury, chronic pain, performance decrements, and increased costs associated with disability benefits. Additionally, unreported injuries can undermine injury surveillance efforts aimed at reducing the musculoskeletal injury problem in the military.
C1 [Smith, Laurel; Westrick, Richard; Sauers, Sarah; Cooper, Adam; Scofield, Dennis; Claro, Pedro; Warr, Bradley] US Army Res Inst Environm Med, 10 Gen Greene Ave, Natick, MA 01760 USA.
RP Smith, L (reprint author), US Army Res Inst Environm Med, 10 Gen Greene Ave, Natick, MA 01760 USA.
EM laurel.b.smith.mil@mail.mil
NR 37
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PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1941-7381
EI 1941-0921
J9 SPORTS HEALTH
JI Sports Health
PD NOV-DEC
PY 2016
VL 8
IS 6
BP 607
EP 613
DI 10.1177/1941738116670873
PG 7
WC Sport Sciences
SC Sport Sciences
GA EG8DN
UT WOS:000391286000003
PM 27789871
ER
PT J
AU Antosh, IJ
Tokish, JM
Owens, BD
AF Antosh, Ivan J.
Tokish, John M.
Owens, Brett D.
TI Posterior Shoulder Instability: Current Surgical Management
SO SPORTS HEALTH-A MULTIDISCIPLINARY APPROACH
LA English
DT Article
DE instability; shoulder arthroscopy; posterior stabilization
ID BONE BLOCK PROCEDURE; ARTHROSCOPIC CAPSULOLABRAL RECONSTRUCTION;
FOLLOW-UP; REPAIR; STABILIZATION; RETROVERSION; DISLOCATION;
SUBLUXATION; OSTEOTOMY; HISTORY
AB Context: Posterior shoulder instability has become more frequently recognized and treated as a unique subset of shoulder instability, especially in the military. Posterior shoulder pathology may be more difficult to accurately diagnose than its anterior counterpart, and commonly, patients present with complaints of pain rather than instability. "Posterior instability" may encompass both dislocation and subluxation, and the most common presentation is recurrent posterior subluxation. Arthroscopic and open treatment techniques have improved as understanding of posterior shoulder instability has evolved.
Evidence Acquisition: Electronic databases including PubMed and MEDLINE were queried for articles relating to posterior shoulder instability. Study Design: Clinical review.
Level of Evidence: Level 4.
Results: In low-demand patients, nonoperative treatment of posterior shoulder instability should be considered a first line of treatment and is typically successful. Conservative treatment, however, is commonly unsuccessful in active patients, such as military members. Those patients with persistent shoulder pain, instability, or functional limitations after a trial of conservative treatment may be considered surgical candidates. Arthroscopic posterior shoulder stabilization has demonstrated excellent clinical outcomes, high patient satisfaction, and low complication rates. Advanced techniques may be required in select cases to address bone loss, glenoid dysplasia, or revision.
Conclusion: Posterior instability represents about 10% of shoulder instability and has become increasingly recognized and treated in military members. Nonoperative treatment is commonly unsuccessful in active patients, and surgical stabilization can be considered in patients who do not respond. Isolated posterior labral repairs constitute up to 24% of operatively treated labral repairs in a military population. Arthroscopic posterior stabilization is typically considered as first-line surgical treatment, while open techniques may be required in complex or revision settings.
C1 [Antosh, Ivan J.] Keller Army Hosp, West Point, NY USA.
[Tokish, John M.] Steadman Hawkins Clin Carolinas, Spartanburg, SC USA.
[Owens, Brett D.] Brown Univ, Alpert Med Sch, Providence, RI 02912 USA.
RP Owens, BD (reprint author), Brown Univ, Alpert Med Sch, Orthopaed Surg, 100 Butler Dr, Providence, RI 02906 USA.
EM owensbrett@gmail.com
FU Arthrex; Depuy-Mitek; Mitek; MTF/Conmed
FX The following authors declared potential conflicts of interest: John M.
Tokish, MD, is a paid consultant for Arthrex and Depuy-Mitek and Brett
D. Owens, MD, is a paid consultant for Mitek and MTF/Conmed.
NR 48
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PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1941-7381
EI 1941-0921
J9 SPORTS HEALTH
JI Sports Health
PD NOV-DEC
PY 2016
VL 8
IS 6
BP 620
EP 626
DI 10.1177/1941738116672446
PG 7
WC Sport Sciences
SC Sport Sciences
GA EG8DN
UT WOS:000391286000005
PM 27697889
ER
PT J
AU Harmon, RS
Worner, G
Goldsmith, ST
Harmon, BA
Gardner, CB
Lyons, WB
Ogden, FL
Pribil, MJ
Long, DT
Kern, Z
Forizs, I
AF Harmon, Russell S.
Woerner, Gerhard
Goldsmith, Steven T.
Harmon, Brendan A.
Gardner, Christopher B.
Lyons, W. Berry
Ogden, Fred L.
Pribil, Michael J.
Long, David T.
Kern, Zoltan
Forizs, Istvan
TI Linking silicate weathering to riverine geochemistry-A case study from a
mountainous tropical setting in west-central Panama
SO GEOLOGICAL SOCIETY OF AMERICA BULLETIN
LA English
DT Article
ID TRANSATLANTIC DUST TRANSPORT; SELVA BIOLOGICAL STATION; MAJOR-ELEMENT
CHEMISTRY; STABLE-ISOTOPE VALUES; AMERICAN LAND-BRIDGE; EASTERN
PUERTO-RICO; NSIMI-ZOETELE SITE; EL-VALLE VOLCANO; COSTA-RICA; CO2
CONSUMPTION
AB Chemical analyses from 71 watersheds across an similar to 450 km transect in west-central Panama provide insight into controls on weathering and rates of chemical denudation and CO2 consumption across an igneous arc terrain in the tropics. Stream and river compositions across this region of Panama are generally dilute, having a total dissolved -solute value = 118 +/- 91 mg/L, with bicarbonate and silica being the predominant dissolved species. Solute, stable isotope, and radio-genic isotope compositions are consistent with dissolution of igneous rocks present in Panama by meteoric precipitation, with geochemical signatures of rivers largely acquired in their upstream regions. Comparison of a head-water basin with its entire watershed observed considerably more runoff production from the high-elevation upstream portion of the catchment than in its much more spatially extensive downstream region. Rock alteration profiles document that weathering proceeds primarily by dissolution of feldspar and pyrox-ene, with base cations effectively leached in the following sequence: Na > Ca > Mg > K. Control on water chemistry by bedrock lithology is indicated through a linking of elevated ([Na + K]/[Ca + Mg]) ratios in -waters to a high proportion of catchment area silicic bedrock and low ratios to mafic bedrock. Sr-isotope ratios are dominated by basementderived Sr, with only very minor, if any, contribution from other sources. Cation weather-ing of Ca-sil + Mg-sil + Na + K spans about an order in magnitude, from 3 to 32 tons/km(2)/yr. Strong positive correlations of chemical denudation and CO2 consumption are observed with precipitation, mean watershed elevation, extent of land surface forest cover, and physical erosion rate.
C1 [Harmon, Russell S.; Harmon, Brendan A.] North Carolina State Univ, Dept Marine Earth & Atmospher Sci, Raleigh, NC 27695 USA.
[Harmon, Russell S.] US Army, Corps Engineers, Int Res Off, Engineer Res & Dev Ctr, Ruislip HA4 7HB, England.
[Woerner, Gerhard] Univ Gottingen, Geosci Ctr, Div Geochem, D-37077 Gottingen, Germany.
[Goldsmith, Steven T.] Villanova Univ, Dept Geog & Environm, Villanova, PA 19085 USA.
[Gardner, Christopher B.; Lyons, W. Berry] Ohio State Univ, Sch Earth Sci, Columbus, OH 43210 USA.
[Ogden, Fred L.] Univ Wyoming, Dept Civil & Architectural Engn, Laramie, WY 82071 USA.
[Pribil, Michael J.] US Geol Survey, POB 25046,MS973, Denver, CO 80225 USA.
[Long, David T.] Michigan State Univ, Dept Geol Sci, E Lansing, MI 48824 USA.
[Kern, Zoltan; Forizs, Istvan] Hungarian Acad Sci, Res Ctr Astron & Earth Sci, Budaorsi Ut 45, H-1112 Budapest, Hungary.
RP Harmon, RS (reprint author), North Carolina State Univ, Dept Marine Earth & Atmospher Sci, Raleigh, NC 27695 USA.; Harmon, RS (reprint author), US Army, Corps Engineers, Int Res Off, Engineer Res & Dev Ctr, Ruislip HA4 7HB, England.
EM russell.s.harmon.civ@mail.mil
FU Smithsonian Tropical Research Institute; U.S. National Science
Foundation [EAR-1045166]; German National Science Foundation [DFG Wo
362/27-1]; Army Research Laboratory
FX We thank the following organizations and people for logistic assistance
and help in collection of samples across Panama from 2004 to 2012:
Thomas Exenberger and Thomas Jakits of Helipan Panama; Lance Vander Zyl
of U.S. Army Yuma Proving Ground Tropic Regions Test Center; and Eric
Nicolaisen, Alonso Iglesias, and Ricardo Martinez of TRAX Evaluacion
Ambiental, S.A. Additional thanks are due to Gregg McElwee, Danny
Rutherford, Kathleen Welch, Susan Welch, Becki Witherow, and Anne Carey
for their assistance with sample collection and analysis. Field support
for this work was provided by the Yuma Proving Ground Tropic Regions
Test Center. Support from the Smithsonian Tropical Research Institute,
by providing access to the Agua Salud project sites in the Trans-Isthmus
region, is gratefully acknowledged. Ideas developed in this paper
occurred while conducting research under U.S. National Science
Foundation grant EAR-1045166 to Lyons and Ogden, a German National
Science Foundation grant DFG Wo 362/27-1 to Worner, and Army Research
Laboratory Fellow research stipends to Harmon from 2005 to 2011.
Analytical support from the U.S. Geological Survey Minerals and the
Environment Resource Science Center is gratefully acknowledged. Worner
acknowledges the contribution from an unpublished B.Sc. thesis by S.
Striepe (2007) and additional analytical support by G. Hartmann and K.
Simon. Any use herein of trade, product, or firm names is for
descriptive purposes only and does not imply endorsement by the U.S.
government.
NR 197
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U1 4
U2 4
PU GEOLOGICAL SOC AMER, INC
PI BOULDER
PA PO BOX 9140, BOULDER, CO 80301-9140 USA
SN 0016-7606
EI 1943-2674
J9 GEOL SOC AM BULL
JI Geol. Soc. Am. Bull.
PD NOV
PY 2016
VL 128
IS 11-12
BP 1780
EP 1812
DI 10.1130/B31388.1
PG 33
WC Geosciences, Multidisciplinary
SC Geology
GA EG4BL
UT WOS:000390988300012
ER
PT J
AU Maina, AN
Luce-Fedrow, A
Omulo, S
Hang, J
Chan, TC
Ade, F
Jima, DD
Ogola, E
Ge, H
Breiman, RF
Njenga, MK
Richards, AL
AF Maina, Alice N.
Luce-Fedrow, Alison
Omulo, Sylvia
Hang, Jun
Chan, Teik-Chye
Ade, Fredrick
Jima, Dereje D.
Ogola, Eric
Ge, Hong
Breiman, Robert F.
Njenga, Moses K.
Richards, Allen L.
TI Isolation and characterization of a novel Rickettsia species (Rickettsia
asembonensis sp nov.) obtained from cat fleas (Ctenocephalides felis)
SO INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY
LA English
DT Article
ID BARTONELLA; IDENTIFICATION; ASEMBOENSIS; DOGS; SIPHONAPTERA; PHYLOGENY;
EHRLICHIA; ANAPLASMA; ORGANISM; INSIGHT
AB A novel rickettsial agent, 'Candidatus Rickettsia asembonensis' strain NMRCii(T), was isolated from cat fleas, Ctenocephalides felis, from Kenya. Genotypic characterization of the new isolate based on sequence analysis of five rickettsial genes, rrs, gltA, ompA, ompB and sca4, indicated that this isolate clustered with Rickettsia felis URRWXCal2. The degree of nucleotide similarity demonstrated that isolate NMRCii(T) belongs within the genus Rickettsia and fulfils the criteria for classification as a representative of a novel species. The name Rickettsia asembonensis sp. nov. is proposed, with NMRCii(T) (=DSM 100172(T)=CDC CRIRC RAS001(T)=ATCC VR-1827(T)) as the type strain.
C1 [Maina, Alice N.; Luce-Fedrow, Alison; Chan, Teik-Chye; Ge, Hong; Richards, Allen L.] Naval Med Res Ctr, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
[Luce-Fedrow, Alison] Shippensburg Univ, 1871 Old Main Dr, Shippensburg, PA 17257 USA.
[Omulo, Sylvia; Ade, Fredrick; Ogola, Eric; Njenga, Moses K.] Kenya Govt Med Res Ctr, Kisumu, Kenya.
[Hang, Jun; Jima, Dereje D.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA.
[Breiman, Robert F.] US Ctr Dis Control & Prevent, Nairobi, Kenya.
RP Maina, AN (reprint author), Naval Med Res Ctr, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM alice.n.maina.ctr@mail.mil
FU Global Disease Detection programme of the US Centers for Disease Control
and Prevention; Global Emerging Infections Surveillance and Response
System, a Division of the Armed Forces Health Surveillance Center
[A1402]
FX We thank the IHAP team (Dr Elkanah Otiang, Julius Ouma, Samuel Asembo,
Michael Otieno, James Oigo and Pauline Otieno) for their assistance
during the collection of flea specimens from dogs and Ju Jiang for her
assistance with control sera for immunofluorescence analysis. This work
was supported by the Global Disease Detection programme of the US
Centers for Disease Control and Prevention and the Global Emerging
Infections Surveillance and Response System, a Division of the Armed
Forces Health Surveillance Center; work unit # A1402.
NR 23
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U1 2
U2 2
PU MICROBIOLOGY SOC
PI LONDON
PA CHARLES DARWIN HOUSE, 12 ROGER ST, LONDON WC1N 2JU, ERKS, ENGLAND
SN 1466-5026
EI 1466-5034
J9 INT J SYST EVOL MICR
JI Int. J. Syst. Evol. Microbiol.
PD NOV
PY 2016
VL 66
BP 4512
EP 4517
DI 10.1099/ijsem.0.001382
PN 11
PG 6
WC Microbiology
SC Microbiology
GA EF9YE
UT WOS:000390686600031
PM 27506201
ER
PT J
AU Nawn, CD
Souhan, BE
Carter, R
Kneapler, C
Fell, N
Ye, JY
AF Nawn, Corinne D.
Souhan, Brian E.
Carter, Robert, III
Kneapler, Caitlin
Fell, Nicholas
Ye, Jing Yong
TI Distinguishing tracheal and esophageal tissues with hyperspectral
imaging and fiber-optic sensing
SO JOURNAL OF BIOMEDICAL OPTICS
LA English
DT Article
DE trachea; esophagus; intubation; fiber optic; hyperspectral camera;
spectral characterization
ID EMERGENCY-DEPARTMENTS; AIRWAY MANAGEMENT; DIFFICULT AIRWAY;
INTENSIVE-CARE; INTUBATION; GUIDELINES
AB During emergency medical situations, where the patient has an obstructed airway or necessitates respiratory support, endotracheal intubation (ETI) is the medical technique of placing a tube into the trachea in order to facilitate adequate ventilation of the lungs. Complications during ETI, such as repeated attempts, failed intubation, or accidental intubation of the esophagus, can lead to severe consequences or ultimately death. Consequently, a need exists for a feedback mechanism to aid providers in performing successful ETI. Our study examined the spectral reflectance properties of the tracheal and esophageal tissue to determine whether a unique spectral profile exists for either tissue for the purpose of detection. The study began by using a hyperspectral camera to image excised pig tissue samples exposed to white and UV light in order to capture the spectral reflectance properties with high fidelity. After identifying a unique spectral characteristic of the trachea that significantly differed from esophageal tissue, a follow-up investigation used a fiber optic probe to confirm the detectability and consistency of the different reflectance characteristics in a pig model. Our results characterize the unique and consistent spectral reflectance characteristic of tracheal tissue, thereby providing foundational support for exploiting spectral properties to detect the trachea during medical procedures. (C) The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication.
C1 [Nawn, Corinne D.; Carter, Robert, III] United States Army Inst Surg Res, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA.
[Nawn, Corinne D.] Oak Ridge Inst Sci & Educ, 4692 Millennium Dr,Suite 101, Belcamp, MD 21017 USA.
[Nawn, Corinne D.; Ye, Jing Yong] Univ Texas San Antonio, One UTSA Circle, San Antonio, TX 78249 USA.
[Nawn, Corinne D.; Carter, Robert, III; Ye, Jing Yong] Univ Texas Hlth Sci Ctr San Antonio, 7703 Floyd Curl Dr,Mail Code 7736, San Antonio, TX 78229 USA.
[Souhan, Brian E.; Kneapler, Caitlin; Fell, Nicholas] US Mil Acad, 606 Thayer Rd, West Point, NY 10996 USA.
RP Nawn, CD (reprint author), United States Army Inst Surg Res, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA.; Nawn, CD (reprint author), Oak Ridge Inst Sci & Educ, 4692 Millennium Dr,Suite 101, Belcamp, MD 21017 USA.; Nawn, CD (reprint author), Univ Texas San Antonio, One UTSA Circle, San Antonio, TX 78249 USA.; Nawn, CD (reprint author), Univ Texas Hlth Sci Ctr San Antonio, 7703 Floyd Curl Dr,Mail Code 7736, San Antonio, TX 78229 USA.
EM nawn.cori@gmail.com
FU Army Research Office of the United States Army Research Laboratory;
Defense Advanced Research Project Agency; Oak Ridge Institute for
Science and Education
FX Support of this work by the Army Research Office of the United States
Army Research Laboratory, the Defense Advanced Research Project Agency,
and the Oak Ridge Institute for Science and Education is acknowledged.
The authors have no conflicts of interest to report pertaining to the
present study. Animal statement: This study has been conducted in
compliance with the Animal Welfare Act, the implementing Animal Welfare
Regulations, and the principles of the Guide for the Care and User of
Laboratory Animals. DoD disclaimer: The opinions or assertions contained
herein are the private views of the author and are not to be construed
as official or as reflecting the views of the Department of the Army or
the Department of Defense.
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PU SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
PI BELLINGHAM
PA 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98225 USA
SN 1083-3668
EI 1560-2281
J9 J BIOMED OPT
JI J. Biomed. Opt.
PD NOV
PY 2016
VL 21
IS 11
AR 117004
DI 10.1117/1.JBO.21.11.117004
PG 10
WC Biochemical Research Methods; Optics; Radiology, Nuclear Medicine &
Medical Imaging
SC Biochemistry & Molecular Biology; Optics; Radiology, Nuclear Medicine &
Medical Imaging
GA EF9RT
UT WOS:000390668200022
PM 27893090
ER
PT J
AU Antebi, B
Benov, A
Mann-Salinas, EA
Le, TD
Cancio, LC
Wenke, JC
Paran, H
Yitzhak, A
Tarif, B
Gross, KR
Dagan, D
Glassberg, E
AF Antebi, Ben
Benov, Avi
Mann-Salinas, Elizabeth A.
Le, Tuan D.
Cancio, Leopoldo C.
Wenke, Joseph C.
Paran, Haim
Yitzhak, Avraham
Tarif, Bader
Gross, Kirby R.
Dagan, David
Glassberg, Elon
TI Analysis of injury patterns and roles of care in US and Israelmilitaries
during recent conflicts: Two are better than one
SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
LA English
DT Article; Proceedings Paper
CT 5th Military Health System Research Symposium
CY AUG, 2015
CL Fort Lauderdale, FL
DE Combat casualty care; Israel Defense Forces; prolonged field care; roles
of care; trauma; US Army
ID COMBAT CASUALTY CARE; OPERATION IRAQI FREEDOM; TRAUMA CARE; ENDURING
FREEDOM; DEFENSE FORCES; BATTLEFIELD; EXPERIENCE; WOUNDS; AFGHANISTAN;
STATISTICS
AB BACKGROUND: As new conflicts emerge and enemies evolve, military medical organizations worldwide must adopt the "lessons learned." In this study, we describe roles of care (ROCs) deployed and injuries sustained by both US and Israeli militaries during recent conflicts. The purpose of this collaborative work is facilitate exchange of medical data among allied forces in order to advance military medicine and facilitate strategic readiness for future military engagements that may involve less predictable situations of evacuation and care, such as prolonged field care.
METHODS: This retrospective study was conducted for the periods of 2003 to 2014 from data retrieved from the Department of Defense Trauma Registry and the Israel Defense Force (IDF) Trauma Registry. Comparative analyses included ROC capabilities, casualties who died of wounds, as well as mechanism of injury, anatomical wound distribution, and Injury Severity Score of US and IDF casualties during recent conflicts.
RESULTS: Although concept of ROCs was similar among militaries, the IDF supports increased capabilities at point of injury and Role 1 including the presence of physicians, but with limited deployment of other ROCs; conversely, the US maintains fewer capabilities at Role 1 but utilized the entire spectrum of care, including extensive deployment of Roles 2/2+, during recent conflicts. Casualties from US forces (n = 19,005) and IDF (n = 2,637) exhibited significant differences in patterns of injury with higher proportions of casualties who died of wounds in the US forces (4%) compared with the IDF (0.6%).
CONCLUSIONS: As these data suggest deployed ROCs and injury patterns of US and Israeli militaries were both conflict and system specific. We envision that identification of discordant factors and common medical strategies of the two militaries will enable strategic readiness for future conflicts as well as foster further collaboration among allied forces with the overarching universal goal of eliminating preventable death on the battlefield. Copyright (C) 2016 Wolters Kluwer Health, Inc. All rights reserved.)
C1 [Antebi, Ben; Mann-Salinas, Elizabeth A.; Le, Tuan D.; Cancio, Leopoldo C.; Wenke, Joseph C.; Gross, Kirby R.] JBSA, US Army Inst Surg Res, Ft Sam Houston, TX USA.
[Benov, Avi; Paran, Haim] Meir Med Ctr, Dept Surg A, Kefar Sava, Israel.
[Benov, Avi; Paran, Haim] Tel Aviv Univ, Sackler Sch Med, Tel Aviv, Israel.
[Benov, Avi; Yitzhak, Avraham; Tarif, Bader; Dagan, David; Glassberg, Elon] Israel Def Forces Med Corps, Ramat Gan, Israel.
[Antebi, Ben; Tarif, Bader] Hebrew Univ Jerusalem, Dept Mil Med, Jerusalem, Israel.
[Antebi, Ben] Geneva Fdn, Tacoma, WA USA.
RP Antebi, B (reprint author), Geneva Fdn, Tacoma, WA USA.; Antebi, B (reprint author), JBSA, 3698 Chambers Pass Bldg 3610, Ft Sam Houston, TX 78234 USA.
EM benantebi@gmail.com
NR 44
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 2163-0755
EI 2163-0763
J9 J TRAUMA ACUTE CARE
JI J. Trauma Acute Care Surg.
PD NOV
PY 2016
VL 81
IS 5
SU 2
BP S87
EP S94
DI 10.1097/TA.0000000000001252
PG 8
WC Critical Care Medicine; Surgery
SC General & Internal Medicine; Surgery
GA EF3XH
UT WOS:000390257800006
PM 27602905
ER
PT J
AU Laurencot, CM
Dean, W
Borek, ML
Klein, NM
AF Laurencot, Carolyn M.
Dean, Wendy
Borek, M. Lisa
Klein, Natalie M.
TI Transitioning trauma research: Navigating the regulatory requirements
for medical product development
SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
LA English
DT Editorial Material
C1 [Laurencot, Carolyn M.; Dean, Wendy; Borek, M. Lisa] US Army Med Mat Dev Act, Ft Detrick, MD USA.
[Klein, Natalie M.] US Army Med Res & Mat Command, Off Res Protect, Ft Detrick, MD USA.
RP Klein, NM (reprint author), US Army Med Res & Mat Command, Off Res Protect, ATTN MCMR RP, 810 Schreider St, Ft Detrick, MD 21702 USA.
EM natalie.m.klein.civ@mail.mil
NR 19
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 2163-0755
EI 2163-0763
J9 J TRAUMA ACUTE CARE
JI J. Trauma Acute Care Surg.
PD NOV
PY 2016
VL 81
IS 5
SU 2
BP S81
EP S86
DI 10.1097/TA.0000000000001247
PG 6
WC Critical Care Medicine; Surgery
SC General & Internal Medicine; Surgery
GA EF3XH
UT WOS:000390257800005
PM 27642779
ER
PT J
AU Liu, NT
Salinas, J
AF Liu, Nehemiah T.
Salinas, Jose
TI Machine learning and new vital signs monitoring in civilian en route
care: A systematic review of the literature and future implications for
the military
SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
LA English
DT Article; Proceedings Paper
CT 5th Military Health System Research Symposium
CY AUG, 2015
CL Fort Lauderdale, FL
DE En route care; helicopter emergency medical services; prehospital;
trauma; technology
ID EMERGENCY MEDICAL-SERVICES; HEART-RATE-VARIABILITY; LIFESAVING
INTERVENTIONS; TRAUMA PATIENTS; RATE COMPLEXITY; PREDICTION; NEED;
DEPARTMENTS; DIAGNOSIS; MORTALITY
AB BACKGROUND: Although air transport medical services are today an integral part of trauma systems in most developed countries, to date, there are no reviews on recent innovations in civilian en route care. The purpose of this systematic review was to identify potential machine learning and new vital signs monitoring technologies in civilian en route care that could help close civilian and military capability gaps in monitoring and the early detection and treatment of various trauma injuries.
METHODS: MEDLINE, the Cochrane Database of Systematic Reviews, and citation review of relevant primary and review articles were searched for studies involving civilian en route care, air medical transport, and technologies from January 2005 to November 2015. Data were abstracted on study design, population, year, sponsors, innovation category, details of technologies, and outcomes.
RESULTS: Thirteen observational studies involving civilian medical transport met inclusion criteria. Studies either focused on machine learning and software algorithms (n = 5), new vital signs monitoring (n = 6), or both (n = 2). Innovations involved continuous digital acquisition of physiologic data and parameter extraction. Importantly, all studies (n = 13) demonstrated improved outcomes where applicable and potential use during civilian and military en route care. However, almost all studies required further validation in prospective and/or randomized controlled trials.
CONCLUSION: Potential machine learning technologies and monitoring of novel vital signs such as heart rate variability and complexity in civilian en route care could help enhance en route care for our nation's war fighters. In a complex global environment, they could potentially fill capability gaps such as monitoring and the early detection and treatment of various trauma injuries. However, the impact of these innovations and technologies will require further validation before widespread acceptance and prehospital use. Copyright (C) 2016 Wolters Kluwer Health, Inc. All rights reserved.)
C1 [Liu, Nehemiah T.; Salinas, Jose] US Army Inst Surg Res, 3698 Chambers Pass, San Antonio, TX 78234 USA.
RP Liu, NT (reprint author), US Army Inst Surg Res, 3698 Chambers Pass, San Antonio, TX 78234 USA.
EM nehemiah.liu@us.army.mil
NR 24
TC 0
Z9 0
U1 11
U2 11
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 2163-0755
EI 2163-0763
J9 J TRAUMA ACUTE CARE
JI J. Trauma Acute Care Surg.
PD NOV
PY 2016
VL 81
IS 5
SU 2
BP S111
EP S115
DI 10.1097/TA.0000000000000937
PG 5
WC Critical Care Medicine; Surgery
SC General & Internal Medicine; Surgery
GA EF3XH
UT WOS:000390257800010
PM 26670115
ER
PT J
AU Liu, NT
Salinas, J
Fenrich, CA
Serio-Melvin, ML
Kramer, GC
Driscoll, IR
Schreiber, MA
Cancio, LC
Chung, KK
AF Liu, Nehemiah T.
Salinas, Jose
Fenrich, Craig A.
Serio-Melvin, Maria L.
Kramer, George C.
Driscoll, Ian R.
Schreiber, Martin A.
Cancio, Leopoldo C.
Chung, Kevin K.
TI Predicting the proportion of full-thickness involvement for any given
burn size based on burn resuscitation volumes
SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
LA English
DT Article; Proceedings Paper
CT 5th Military Health System Research Symposium
CY AUG, 2015
CL Fort Lauderdale, FL
DE Fluid resuscitation; total body surface area burned; full thickness;
burn injury; trauma
ID ABDOMINAL COMPARTMENT SYNDROME; FLUID RESUSCITATION; INHALATION INJURY;
INTRAABDOMINAL HYPERTENSION; MILITARY CASUALTIES; IMPROVES OUTCOMES;
REQUIREMENTS; FORMULA; PATIENT
AB INTRODUCTION: The depth of burn has been an important factor often overlooked when estimating the total resuscitation fluid needed for early burn care. The goal of this study was to determine the degree to which full-thickness (FT) involvement affected overall 24-hour burn resuscitation volumes.
METHODS: We performed a retrospective review of patients admitted to our burn intensive care unit from December 2007 to April 2013, with significant burns that required resuscitation using our computerized decision support system for burn fluid resuscitation. We defined the degree of FT involvement as FT Index (FTI; percentage of FT injury/percentage of total body surface area (TBSA) burned [% FT /% TBSA]) and compared variables on actual 24-hour fluid resuscitation volumes overall as well as for any given burn size.
RESULTS: A total of 203 patients admitted to our burn center during the study periodwere included in the analysis. Mean age andweight were 47 +/- 19 years and 87 +/- 18 kg, respectively. Mean % TBSA was 41 +/- 20 with a mean % FT of 18 +/- 24. As % TBSA, % FT, and FTI increased, so did actual 24-hour fluid resuscitation volumes (mL/kg). However, increase in FTI did not result in increased volume indexed to burn size (mL/kg per % TBSA). This was true even when patients with inhalation injury were excluded. Further investigation revealed that as % TBSA increased, % FT increased nonlinearly (quadratic polynomial) (R-2 = 0.994).
CONCLUSION: Total burn size and FT burn sizewere both highly correlated with increased 24-hour fluid resuscitation volumes. However, FTI did not correlate with a corresponding increase in resuscitation volumes for any given burn size, even when patients with inhalation injury were excluded. Thus, there are insufficient data to presume that those who receive more volume at any given burn size are likely to be mostly full thickness or vice versa. This was influenced by a relatively low sample size at each 10% TBSA increment and larger burn sizes disproportionately having more FT burns. A more robust sample size may elucidate this relationship better. Copyright (C) 2016 Wolters Kluwer Health, Inc. All rights reserved.)
C1 [Liu, Nehemiah T.; Salinas, Jose; Fenrich, Craig A.; Serio-Melvin, Maria L.; Driscoll, Ian R.; Cancio, Leopoldo C.; Chung, Kevin K.] US Army Inst Surg Res, Ft Sam Houston, TX USA.
[Kramer, George C.] Univ Texas Med Branch, Dept Anesthesiol, Resuscitat Res Lab, Galveston, TX 77555 USA.
[Schreiber, Martin A.] Oregon Hlth & Sci Univ, Div Trauma Crit Care & Acute Care Surg, Portland, OR 97201 USA.
[Chung, Kevin K.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
RP Liu, NT (reprint author), US Army Inst Surg Res, 3698 Chambers Pass, Jbsa Ft Sam Houston, TX 78234 USA.
EM nehemiah.liu@us.army.mil
NR 30
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 2163-0755
EI 2163-0763
J9 J TRAUMA ACUTE CARE
JI J. Trauma Acute Care Surg.
PD NOV
PY 2016
VL 81
IS 5
SU 2
BP S144
EP S149
DI 10.1097/TA.0000000000001166
PG 6
WC Critical Care Medicine; Surgery
SC General & Internal Medicine; Surgery
GA EF3XH
UT WOS:000390257800016
PM 27768662
ER
PT J
AU Mann-Salinas, EA
Le, TD
Shackelford, SA
Bailey, JA
Stockinger, ZT
Spott, MA
Wirt, MD
Rickard, R
Lane, IB
Hodgetts, T
Cardin, S
Remick, KN
Gross, KR
AF Mann-Salinas, Elizabeth A.
Le, Tuan D.
Shackelford, Stacy A.
Bailey, Jeffrey A.
Stockinger, Zsolt T.
Spott, Mary Ann
Wirt, Michael D.
Rickard, Rory
Lane, Ian B.
Hodgetts, Timothy
Cardin, Sylvain
Remick, Kyle N.
Gross, Kirby R.
TI Evaluation of role 2 (R2) medical resources in the Afghanistan combat
theater: Initial review of the joint trauma system R2 registry
SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
LA English
DT Article; Proceedings Paper
CT 5th Military Health System Research Symposium
CY AUG, 2015
CL Fort Lauderdale, FL
DE Combat; trauma; forward surgical care; joint trauma system; role 2
ID OPERATION-IRAQI-FREEDOM; PREDICTING SURGEON UTILIZATION;
US-MARINE-CORPS; SURGICAL-TEAM; ENDURING-FREEDOM; EXPERIENCE;
CASUALTIES; BATTLEFIELD; ARMY; CARE
AB BACKGROUND: A Role 2 registry (R2R) was developed in 2008 by the US Joint Trauma System (JTS). The purpose of this project was to undertake a preliminary review of the R2R to understand combat trauma epidemiology and related interventions at these facilities to guide training and optimal use of forward surgical capability in the future.
METHODS: A retrospective review of available JTS R2R records; the registry is a convenience sample entered voluntarily by members of the R2 units. Patients were classified according to basic demographics, affiliation, region where treatment was provided, mechanism of injury, type of injury, time and method of transport from point of injury (POI) to R2 facility, interventions at R2, and survival. Analysis included trauma patients aged >= 18 years or older wounded in year 2008 to 2014, and treated in Afghanistan.
RESULTS: A total of 15,404 patients wounded and treated in R2 were included in the R2R from February 2008 to September 2014; 12,849 patients met inclusion criteria. The predominant patient affiliations included US Forces, 4,676 (36.4%); Afghan Forces, 4,549 (35.4%); and Afghan civilians, 2,178 (17.0%). Overall, battle injuries predominated (9,792 [76.2%]). Type of injury included penetrating, 7,665 (59.7%); blunt, 4,026 (31.3%); and other, 633 (4.9%). Primary mechanism of injury included explosion, 5,320 (41.4%); gunshot wounds, 3,082 (24.0%); and crash, 1,209 (9.4%). Of 12,849 patients who arrived at R2, 167 (1.3%) were dead; of 12,682 patients who were alive upon arrival, 342 (2.7%) died at R2.
CONCLUSION: This evaluation of the R2R describes the patient profiles of and common injuries treated in a sample of R2 facilities in Afghanistan. Ongoing and detailed analysis of R2R information may provide evidence-based guidance to military planners and medical leaders to best prepare teams and allocate R2 resources in future operations. Given the limitations of the data set, conclusions must be interpreted in context of other available data and analyses, not in isolation. Copyright (C) 2016 Wolters Kluwer Health, Inc. All rights reserved.
C1 [Mann-Salinas, Elizabeth A.; Le, Tuan D.; Shackelford, Stacy A.; Spott, Mary Ann; Wirt, Michael D.; Gross, Kirby R.] US Army Inst Surg Res, San Antonio, TX USA.
[Bailey, Jeffrey A.] Uniformed Serv Univ Hlth Sci, Dept Surg, Bethesda, MD 20814 USA.
[Bailey, Jeffrey A.] Walter Reed Natl Mil Med Ctr, Bethesda, MD USA.
[Stockinger, Zsolt T.] Joint Trauma Syst, San Antonio, TX USA.
[Rickard, Rory; Hodgetts, Timothy] Royal Ctr Def Med, Birmingham, W Midlands, England.
[Lane, Ian B.] US Army Med Dept Ctr & Sch, San Antonio, TX USA.
[Cardin, Sylvain; Remick, Kyle N.] US Army Med Res & Mat Command, Ft Detrick, MD USA.
RP Mann-Salinas, EA (reprint author), US Army Inst Surg Res, San Antonio Mil Med Ctr, 3698 Chambers Pass,Ste B,Bldg 3611, Houston, TX 78234 USA.
EM Elizabeth.a.mannsalinas.mil@mail.mil
NR 29
TC 0
Z9 0
U1 1
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 2163-0755
EI 2163-0763
J9 J TRAUMA ACUTE CARE
JI J. Trauma Acute Care Surg.
PD NOV
PY 2016
VL 81
IS 5
SU 2
BP S121
EP S127
DI 10.1097/TA.0000000000001092
PG 7
WC Critical Care Medicine; Surgery
SC General & Internal Medicine; Surgery
GA EF3XH
UT WOS:000390257800012
PM 27120324
ER
PT J
AU Nnamani, NS
Janak, JC
Hudak, SJ
Rivera, JC
Lewis, EA
Soderdahl, DW
Orman, JA
AF Nnamani, Nina S.
Janak, Judson C.
Hudak, Steven J.
Rivera, Jessica C.
Lewis, Eluned A.
Soderdahl, Douglas W.
Orman, Jean A.
TI Genitourinary injuries and extremity amputation in Operations Enduring
Freedom and Iraqi Freedom: Early findings from the Trauma Outcomes and
Urogenital Health (TOUGH) project
SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
LA English
DT Article; Proceedings Paper
CT 5th Military Health System Research Symposium
CY AUG, 2015
CL Fort Lauderdale, FL
DE Genitourinary injury; urotrauma; extremity amputation; Operation Iraqi
Freedom; Operation Enduring Freedom
ID IMPROVISED EXPLOSIVE DEVICES; MILITARY PERSONNEL; EXTERNAL GENITALIA;
CURRENT CONFLICTS; BLAST INJURY; AFGHANISTAN; DYSFUNCTION; STRENGTH;
IMPACT; RETURN
AB BACKGROUND: In Operation Enduring Freedom and Operation Iraqi Freedom (OEF/OIF), genitourinary (GU) wounds have occurred in unprecedented numbers. Severe concomitant injuries, including extremity amputations, are common. The epidemiology of GU injury and extremity amputation in OEF/OIF has not been described.
MATERIALS AND METHODS: The Department of Defense Trauma Registry was queried from October 2001 through August 2013 to identify all surviving US male service members with GU injuries sustained in OEF/OIF. Genitourinary injury was defined as sustaining one or more injuries to any organ or structure within the genitourinary and/or reproductive system(s) based on International Classification of Diseases, Ninth Revision, Clinical Modification diagnosis codes. Injury severity was quantified based on Abbreviated Injury Scale scores and overall Injury Severity Scores. The incidence, nature, and severity of GU injuries and extremity amputations are described.
RESULTS: Of the 1,367 service members with GU injury included in this analysis, 433 (31.7%) had one or more extremity amputations. Most GU injuries were to the external genitalia [scrotum (55.6%), testes (33.0%), penis (31.0%), and urethra (9.1%)] vs. the kidneys (21.1%). Those with amputation(s) had greater GU injury severity (Abbreviated Injury Scale score >= 3) than those without amputations (50.1% vs. 30.5%, respectively; p < 0.0001). Approximately 3.4% of male service members with GU injury had an upper extremity amputation only, 8.9% had both lower and upper extremity amputation(s), and 19.4% had lower extremity amputation(s) only. Of the 387 patients with GU injury and lower extremity amputations, 87 (22.5%) had amputations below the knee and 300 (77.5%) had amputation(s) at/above the knee.
CONCLUSION: In OEF/OIF, concomitant GU injury and extremity amputation are common and have serious implications for health and quality of life. This wounding pattern presents new challenges to the military medical and research and development communities to prevent, mitigate, and treat these battlefield injuries. Copyright (C) 2016 Wolters Kluwer Health, Inc. All rights reserved.)
C1 [Nnamani, Nina S.; Janak, Judson C.; Rivera, Jessica C.] US Army Inst Surg Res, Jbsa Ft Sam Houston, TX USA.
[Hudak, Steven J.] San Antonio Mil Med Ctr, Urol Serv, Dept Surg, Jbsa Ft Sam Houston, TX USA.
[Rivera, Jessica C.] San Antonio Mil Med Ctr, Dept Orthopaed, Jbsa Ft Sam Houston, TX USA.
[Lewis, Eluned A.] Minist Def, Technol Off, Def Equipment & Support, Bristol, Avon, England.
[Soderdahl, Douglas W.] San Antonio Mil Med Ctr, Surg Serv, Jbsa Ft Sam Houston, TX USA.
[Orman, Jean A.] US Army Inst Surg Res, Joint Trauma Syst, Ft Sam Houston, TX USA.
[Orman, Jean A.] Univ Texas Hlth Sci Ctr San Antonio, Dept Epidemiol & Biostat, San Antonio, TX 78229 USA.
RP Orman, JA (reprint author), US Army Inst Surg Res, Joint Trauma Syst, MCMR SRJ, 3698 Chambers Pass,Bldg 3611, Jbsa Ft Sam Houston, TX 78234 USA.
EM jean.a.orman.civ@mail.mil
NR 32
TC 0
Z9 0
U1 1
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 2163-0755
EI 2163-0763
J9 J TRAUMA ACUTE CARE
JI J. Trauma Acute Care Surg.
PD NOV
PY 2016
VL 81
IS 5
SU 2
BP S95
EP S99
DI 10.1097/TA.0000000000001122
PG 5
WC Critical Care Medicine; Surgery
SC General & Internal Medicine; Surgery
GA EF3XH
UT WOS:000390257800007
PM 27768657
ER
PT J
AU Park, PK
Cannon, JW
Ye, W
Blackbourne, LH
Holcomb, JB
Beninati, W
Napolitano, LM
AF Park, Pauline K.
Cannon, Jeremy W.
Ye, Wen
Blackbourne, Lorne H.
Holcomb, John B.
Beninati, William
Napolitano, Lena M.
TI Incidence, risk factors, and mortality associated with acute respiratory
distress syndrome in combat casualty care
SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
LA English
DT Article; Proceedings Paper
CT 5th Military Health System Research Symposium
CY AUG, 2015
CL Fort Lauderdale, FL
DE Acute respiratory distress syndrome; combat casualty; critical care
resource utilization; mortality; respiratory failure
ID ACUTE LUNG INJURY; OPERATION ENDURING FREEDOM; ILL TRAUMA PATIENTS;
DECREASING INCIDENCE; AIR TRANSPORT; UNITED-STATES; BLUNT TRAUMA; RESCUE
TEAM; ARDS; SUPPORT
AB BACKGROUND: The overall incidence and mortality of acute respiratory distress syndrome (ARDS) in civilian trauma settings have decreased over the past four decades; however, the epidemiology and impact of ARDS on modern combat casualty care are unknown. We sought to determine the incidence, risk factors, resource utilization, and mortality associated with ARDS in current combat casualty care.
METHODS: This was a retrospective review of mechanically ventilated US combat casualties within the Department of Defense Trauma Registry (formerly the Joint Theater Trauma Registry) during Operation Iraqi Freedom/Enduring Freedom (October 2001 to August 2008) for ARDS development, resource utilization, and mortality.
RESULTS: Of 18,329 US Department of Defense Trauma Registry encounters, 4,679 (25.5%) required mechanical ventilation; ARDS was identified in 156 encounters (3.3%). On multivariate logistic regression, ARDS was independently associated with female sex (odds ratio [OR], 2.62; 95% confidence interval [CI], 1.21-5.71; p = 0.02), higher military-specific Injury Severity Score (Mil ISS) (OR, 4.18; 95% CI, 2.61-6.71; p < 0.001 for Mil ISS >= 25 vs. < 15), hypotension (admission systolic blood pressure < 90 vs. >= 90 mm Hg; OR, 1.76; 95% CI, 1.07-2.88; p = 0.03), and tachycardia (admission heart rate >= 90 vs. < 90 beats per minute; OR, 1.53; 95% CI, 1.06-2.22; p = 0.02). Explosion injury was not associated with increased risk of ARDS. Critical care resource utilization was significantly higher in ARDS patients as was all-cause hospital mortality (ARDS vs. no ARDS, 12.8% vs. 5.9%; p = 0.002). After adjustment for age, sex, injury severity, injury mechanism, Mil ISS, hypotension, tachycardia, and admission Glasgow Coma Scale score, ARDS remained an independent risk factor for death (OR, 1.99; 95% CI, 1.12-3.52; p = 0.02).
CONCLUSIONS: In this large cohort of modern combat casualties, ARDS risk factors included female sex, higher injury severity, hypotension, and tachycardia, but not explosion injury. Patients with ARDS also required more medical resources and were at greater risk of death compared with patients without ARDS. Thus, ARDS remains a significant complication in current combat casualty care. Copyright (C) 2016 Wolters Kluwer Health, Inc. All rights reserved.
C1 [Park, Pauline K.; Napolitano, Lena M.] Univ Michigan, Dept Surg, Div Acute Care Surg, Ann Arbor, MI 48109 USA.
[Ye, Wen] Univ Michigan, Sch Publ Hlth, Ann Arbor, MI 48109 USA.
[Blackbourne, Lorne H.; Holcomb, John B.] US Army Inst Surg Res, Ft Sam Houston, TX USA.
[Beninati, William] Wilford Hall USAF Med Ctr, Pulm Crit Care Med, Lackland AFB, TX USA.
[Cannon, Jeremy W.] Wilford Hall USAF Med Ctr, Dept Surg, Lackland AFB, TX USA.
[Cannon, Jeremy W.] Uniformed Serv Univ Hlth Sci, Dept Surg, Bethesda, MD 20814 USA.
[Cannon, Jeremy W.] Univ Penn, Div Traumatol Surg Crit Care & Emergency Surg, Perelman Sch Med, Philadelphia, PA 19104 USA.
[Blackbourne, Lorne H.] San Antonio Mil Med Ctr, Dept Surg, Ft Sam Houston, TX USA.
[Holcomb, John B.] Univ Texas Houston, Div Trauma & Acute Care Surg, Houston, TX USA.
[Beninati, William] Intermt Healthcare, Salt Lake City, UT USA.
RP Cannon, JW (reprint author), Penn Presbyterian Med Ctr, Div Traumatol Surg Crit Care & Emergency Surg, 51 N 39th St,MOB Suite 120, Philadelphia, PA 19104 USA.
EM jeremy.cannon@uphs.upenn.edu
NR 45
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 2163-0755
EI 2163-0763
J9 J TRAUMA ACUTE CARE
JI J. Trauma Acute Care Surg.
PD NOV
PY 2016
VL 81
IS 5
SU 2
BP S150
EP S156
DI 10.1097/TA.0000000000001183
PG 7
WC Critical Care Medicine; Surgery
SC General & Internal Medicine; Surgery
GA EF3XH
UT WOS:000390257800017
PM 27768663
ER
PT J
AU Pollot, BE
Goldman, SM
Wenke, JC
Corona, BT
AF Pollot, Beth E.
Goldman, Stephen M.
Wenke, Joseph C.
Corona, Benjamin T.
TI Decellularized extracellular matrix repair of volumetric muscle loss
injury impairs adjacent bone healing in a rat model of complex
musculoskeletal trauma
SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
LA English
DT Article; Proceedings Paper
CT 5th Military Health System Research Symposium
CY AUG, 2015
CL Fort Lauderdale, FL
DE Biological scaffold; inflammation and resorption; Lewis rats; open
fracture; skeletal muscle injury
ID TIBIAL SHAFT FRACTURES; SKELETAL-MUSCLE; BIOLOGIC SCAFFOLD;
FASCIOCUTANEOUS TISSUE; MURINE MODEL; IN-VITRO; REGENERATION;
IMPLANTATION; TRANSPLANTATION; COVERAGE
AB BACKGROUND: Traumatic muscle loss (i.e., volumetric muscle loss [VML] injury) impairs adjacent fracture healing but is often left untreated. A promising therapy for this application is a decellularized extracellular matrix (ECM) because of their capacity to regenerate a vascularized tissue bed. This study tested the hypothesis that repair of VML concomitant to fracture with a small intestine submucosa (SIS)-ECM improves musculoskeletal healing.
METHODS: In male Lewis rats (similar to 375 g), a 3-mm segmental bone defect (SBD) was created in concomitance with a 6-mm, full-thickness VML injury to the adjacent tibialis anterior (TA) muscle. For all rats (n = 10), the SBD was treated with internal plate fixation and delivery of recombinant human bone morphogenetic protein 2 (1 mu g) on a collagen sponge. The VML either had no repair or SIS-ECM repair (n = 5/group). Bone regeneration within the SBD(BV/TV [bone volume as a fraction of total volume]) was assessed via in vivo micro-computed tomography at 2, 4, and 6weeks and histology at 6 weeks after injury. Tibialis anterior muscle in vivo strength and histologic assessmentswere performed at 6 weeks after injury.
RESULTS: Compared with no repair, SIS-ECMpresented -21%(p = 0.09) and -27%(p = 0.004) BV/TVat 4 and 6 weeks after injury, respectively. At 6 weeks, the SBD gap length was shorter for the no repair than that for the SIS-ECM (2.64 +/- 0.30 and 3.67 +/- 0.41 mm, respectively; p = 0.09), whereas the distances fromthe end of each cortical segment to the center of the first stabilization screw were longer (1.86 +/- 0.25 and 0.85 +/- 0.30mm, respectively; p = 0.035), indicating enhanced resorption in the SIS-ECMgroup. Both groups presented similar magnitude TA muscle strength deficits compared with their contralateral limbs (10-150 Hz: no repair, -58% to 67%; SIS-ECM, -51% to 74%). The TA muscle of the SIS-ECM group was remarkable for its presentation of fibrosis, edema, and immune cell presence.
CONCLUSIONS: Small intestine submucosa-ECM VML repair impaired open fracture healing and failed to improve skeletal muscle strength. Copyright (C) 2016 Wolters Kluwer Health, Inc. All rights reserved.
C1 [Pollot, Beth E.; Goldman, Stephen M.; Wenke, Joseph C.; Corona, Benjamin T.] US Army Inst Surg Res, Extrem Trauma & Regenerat Med Task Area, Ft Sam Houston, TX 78234 USA.
RP Corona, BT (reprint author), US Army Inst Surg Res, Extrem Trauma & Regenerat Med Task Area, Ft Sam Houston, TX 78234 USA.
EM benjamin.t.corona.vol@mail.mil
NR 35
TC 0
Z9 0
U1 5
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 2163-0755
EI 2163-0763
J9 J TRAUMA ACUTE CARE
JI J. Trauma Acute Care Surg.
PD NOV
PY 2016
VL 81
IS 5
SU 2
BP S184
EP S190
DI 10.1097/TA.0000000000001212
PG 7
WC Critical Care Medicine; Surgery
SC General & Internal Medicine; Surgery
GA EF3XH
UT WOS:000390257800022
PM 27533905
ER
PT J
AU Remick, KN
Baer, DG
Rasmussen, TE
AF Remick, Kyle N.
Baer, David G.
Rasmussen, Todd E.
TI Combat casualty care: Partnering for preparedness
SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
LA English
DT Editorial Material
C1 [Remick, Kyle N.; Baer, David G.; Rasmussen, Todd E.] US Army Med Res & Mat Command, United States Combat Casualty Care Res Program, Ft Detrick, MD USA.
RP Remick, KN (reprint author), 504 Scott St,Bldg 722, Ft Detrick, MD 21702 USA.
EM kyle.n.remick.mil@mail.mil
NR 3
TC 0
Z9 0
U1 1
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 2163-0755
EI 2163-0763
J9 J TRAUMA ACUTE CARE
JI J. Trauma Acute Care Surg.
PD NOV
PY 2016
VL 81
IS 5
SU 2
BP S69
EP S71
DI 10.1097/TA.0000000000001253
PG 3
WC Critical Care Medicine; Surgery
SC General & Internal Medicine; Surgery
GA EF3XH
UT WOS:000390257800001
PM 27602901
ER
PT J
AU Rivera, JC
Greer, RM
Spott, MA
Johnson, AE
AF Rivera, Jessica C.
Greer, Renee M.
Spott, Mary Ann
Johnson, Anthony E.
TI The Military Orthopedic Trauma Registry: The potential of a specialty
specific process improvement tool
SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
LA English
DT Article; Proceedings Paper
CT 5th Military Health System Research Symposium
CY AUG, 2015
CL Fort Lauderdale, FL
DE Combat injury; extremity injury; trauma registry; late amputation
ID OPERATION ENDURING FREEDOM; LOWER-EXTREMITY TRAUMA; LATE AMPUTATION;
IRAQI FREEDOM; COMBAT; COMPLICATIONS
AB BACKGROUND: The Military Orthopaedic Trauma Registry (MOTR) was designed to replicate the Department of Defense Trauma Registry's (DoDTR's) role as pillar for data-driven management of extremity war wounds. The MOTR continuously undergoes quality assurance checks to optimize the registry data for future quality improvement efforts. We conducted a quality assurance survey of MOTR entrants to determine if a simple MOTR data pull could provide robust orthopedic-specific information toward the question of causes for late amputation.
METHODS: Forty-five entrants into the DoDTR with late transtibial amputation were sequentially abstracted into MOTR by MOTR data abstractors. The MOTR record was then examined by an independent reviewer for three data fields pertaining to the events leading up to the late amputation: injury before limb amputation, complications before and after amputation, and complication or other factor directly contributing to the decision for amputation.
RESULTS: Thirty-nine subjects had at least one fracture of the tibial diaphysis, tibial pilon, calcaneus, or multiple foot fractures. Twenty-nine fractures were described as open injuries for which 27 included a Gustilo and Anderson classification in the available data fields. Complications could be identified along the treatment course for 43 of the 45 entrants specific to the amputated limb. A directly contributing factor to late amputation was identified in 36 (80%) of the subjects. Infection, either alone or associated with fracture nonunion, was a contributing factor in 46% of late amputations. Wound infection was the most common complication both before and after the amputation.
CONCLUSION: The MOTR, using a simple data extraction from a few registry fields, can provide a robust amount of information that can direct process and care improvement for severely injured limbs by providing the level of detail pertinent to an orthopedic surgeon. Copyright (C) 2016 Wolters Kluwer Health, Inc. All rights reserved.
C1 [Rivera, Jessica C.] US Army Inst Surg Res, Dept Orthopaed Surg, Jbsa Ft Sam Houston, TX USA.
[Rivera, Jessica C.] San Antonio Mil Med Ctr, Jbsa Ft Sam Houston, TX USA.
[Greer, Renee M.] US Army Inst Surg Res, Jbsa Ft Sam Houston, TX USA.
[Spott, Mary Ann] Joint Trauma Syst, Jbsa Ft Sam Houston, TX USA.
[Johnson, Anthony E.] San Antonio Mil Med Ctr, Dept Orthopaed Surg, 3551 Roger Brooke Dr, Jbsa Ft Sam Houston, TX 78234 USA.
RP Rivera, JC (reprint author), San Antonio Mil Med Ctr, Dept Orthopaed Surg, 3551 Roger Brooke Dr, Jbsa Ft Sam Houston, TX 78234 USA.
EM Jessica.cross@us.army.mil
OI Johnson, Anthony/0000-0002-0506-0059
NR 16
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 2163-0755
EI 2163-0763
J9 J TRAUMA ACUTE CARE
JI J. Trauma Acute Care Surg.
PD NOV
PY 2016
VL 81
IS 5
SU 2
BP S100
EP S103
DI 10.1097/TA.0000000000001145
PG 4
WC Critical Care Medicine; Surgery
SC General & Internal Medicine; Surgery
GA EF3XH
UT WOS:000390257800008
PM 27768658
ER
PT J
AU Klibanov, MV
Nguyen, LH
Sullivan, A
Nguyen, L
AF Klibanov, Michael V.
Nguyen, Loc H.
Sullivan, Anders
Nguyen, Lam
TI A GLOBALLY CONVERGENT NUMERICAL METHOD FOR A 1-D INVERSE MEDIUM PROBLEM
WITH EXPERIMENTAL DATA
SO INVERSE PROBLEMS AND IMAGING
LA English
DT Article
DE Coefficient inverse scattering problem; globally convergent algorithm;
dielectric constant; electromagnetic waves
ID DIELECTRIC-CONSTANTS; CAUCHY-PROBLEMS; EQUATION; SYSTEM
AB In this paper, a reconstruction method for the spatially distributed dielectric constant of a medium from the back scattering wave field in the frequency domain is considered. Our approach is to propose a globally convergent algorithm, which does not require any knowledge of a small neighborhood of the solution of the inverse problem in advance. The Quasi-Reversibility Method (QRM) is used in the algorithm. The convergence of the QRM is proved via a Carleman estimate. The method is tested on both computationally simulated and experimental data.
C1 [Klibanov, Michael V.; Nguyen, Loc H.] Univ North Carolina Charlotte, Dept Math & Stat, Charlotte, NC 28213 USA.
[Sullivan, Anders; Nguyen, Lam] US Army Res Lab, 2800 Powder Mil Rd, Adelphi, MD 20783 USA.
RP Klibanov, MV (reprint author), Univ North Carolina Charlotte, Dept Math & Stat, Charlotte, NC 28213 USA.
EM mklibanv@uncc.edu; lnguye50@uncc.edu; anders.j.sullivan.civ@mail.mil;
lam.h.nguyen2civ@mail.mil
FU US Army Research Laboratory; US Army Research Office grant
[W911NF-15-1-0233]; Office of Naval Research grant [N00014-15-1-2330]
FX The work of the first two authors was supported by US Army Research
Laboratory and US Army Research Office grant W911NF-15-1-0233 and by the
Office of Naval Research grant N00014-15-1-2330.
NR 32
TC 0
Z9 0
U1 0
U2 0
PU AMER INST MATHEMATICAL SCIENCES-AIMS
PI SPRINGFIELD
PA PO BOX 2604, SPRINGFIELD, MO 65801-2604 USA
SN 1930-8337
EI 1930-8345
J9 INVERSE PROBL IMAG
JI Inverse Probl. Imaging
PD NOV
PY 2016
VL 10
IS 4
BP 1057
EP 1085
DI 10.3934/ipi.2016032
PG 29
WC Mathematics, Applied; Physics, Mathematical
SC Mathematics; Physics
GA EF1RB
UT WOS:000390101300008
ER
PT J
AU Kang, H
Floros, MW
Reddinger, JP
AF Kang, Hao
Floros, Matthew W.
Reddinger, Jean-Paul
TI Physics-Based Hydraulic Damper Model for Rotor Structural Loads
SO JOURNAL OF AIRCRAFT
LA English
DT Article
AB A physics-based, fully nonlinear hydraulic damper model was developed within the framework of the Rotorcraft Comprehensive Analysis System in order to facilitate integrated damper and rotorcraft analysis and design. The hydraulic damper governing equations of motion were formulated using flow continuity equations for each hydraulic device within the damper. The developed damper model was compared with bench test data of a hydraulic damper under harmonic oscillation. It was also evaluated as an integrated rotor-damper solution against test data from the NASA-Army UH-60A Airloads Program. For these evaluations, the accuracy of blade load predictions using the newly developed damper model was compared against conventional linear and nonlinear (table lookup) damper models. From these comparisons, the physics-based damper model is able to capture the hysteresis loops of the isolated damper under harmonic oscillation and provide physical insight by modeling the damper's component parts. When integrated into Rotorcraft Comprehensive Analysis System, the physics-based model was found to be consistent with the legacy nonlinear model for calculating blade loads for the high-speed and high-thrust conditions evaluated.
C1 [Kang, Hao; Floros, Matthew W.] US Army Res Lab, Vehicle Technol Directorate, 4603 Flare Loop, Aberdeen Proving Ground, MD 21005 USA.
[Reddinger, Jean-Paul] Rensselaer Polytech Inst, Rotorcraft Adapt & Morphing Struct Lab, 110 8th Street, Troy, NY 12180 USA.
[Kang, Hao; Floros, Matthew W.; Reddinger, Jean-Paul] AIAA, Reston, VA USA.
RP Kang, H (reprint author), US Army Res Lab, Vehicle Technol Directorate, 4603 Flare Loop, Aberdeen Proving Ground, MD 21005 USA.
NR 14
TC 0
Z9 0
U1 1
U2 1
PU AMER INST AERONAUTICS ASTRONAUTICS
PI RESTON
PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091-4344 USA
SN 0021-8669
EI 1533-3868
J9 J AIRCRAFT
JI J. Aircr.
PD NOV
PY 2016
VL 53
IS 6
BP 1697
EP 1708
DI 10.2514/1.C033735
PG 12
WC Engineering, Aerospace
SC Engineering
GA EF1PP
UT WOS:000390097300011
ER
PT J
AU Ghoreyshi, M
Bergeron, K
Seidel, J
Jirasek, A
Lofthouse, AJ
Cummings, RM
AF Ghoreyshi, Mehdi
Bergeron, Keith
Seidel, Jurgen
Jirasek, Adam
Lofthouse, Andrew J.
Cummings, Russell M.
TI Prediction of Aerodynamic Characteristics of Ram-Air Parachutes
SO JOURNAL OF AIRCRAFT
LA English
DT Article; Proceedings Paper
CT 32nd AIAA Applied Aerodynamics Conference
CY JUN 16-20, 2014
CL Atlanta, GA
SP AIAA
ID TURBULENCE MODELS; CANOPY; FLOWS
AB The focus of this work is on the computational methodology for aerodynamic modeling of ram-air parachutes and increasing confidence and understanding in their concept designs including new parachute control methods. The complex geometries of ram-air parachutes are modeled by two-dimensional rigid airfoil geometries with or without trailing-edge deflections and bleed air spoilers. The aerodynamic forces are then calculated from steady or unsteady Reynolds-averaged Navier-Stokes simulations using Cobalt and Kestrel flow solvers. The effects of the grid size and type, the time step, and the choice of solver parameters are investigated. The flow solvers are then used to study the flow around three-dimensional wings with open/closed ram-air inlets by comparing lift and drag coefficients with available experimental data. The results show that computational fluid dynamics simulations are a valuable aid in understanding the flow structure of ram-air parachutes, which resemble a rectangular wing with open inlets. However, the computational solutions of these geometries have initial oscillations of large amplitude and converge slowly compared to closed wings/airfoils. The simulation of open geometry should run unsteady and for a large number of time steps. It is also shown that an open-inlet geometry has smaller lift and larger drag, and it stalls earlier than a closed-inlet geometry. Although the air reaches stagnation conditions inside the cavity present in an open airfoil, the air pressure inside the wing cells is less than the stagnation pressure. The flow investigations show that eddies are formed on the lower surface of the open airfoil and wings; however, the wing eddy size varies in the spanwise direction. Finally, the grid sensitivity results show that the solutions of open geometries are very sensitive to the grid quality.
C1 [Ghoreyshi, Mehdi; Jirasek, Adam; Lofthouse, Andrew J.; Cummings, Russell M.] US Air Force Acad, High Performance Comp Res Ctr, Colorado Springs, CO 80840 USA.
[Seidel, Jurgen] US Air Force Acad, Dept Aeronaut, Colorado Springs, CO 80840 USA.
[Bergeron, Keith] US Army, Natick Res Dev & Engn Ctr, Natick, MA 01760 USA.
[Ghoreyshi, Mehdi; Bergeron, Keith; Seidel, Jurgen; Jirasek, Adam; Lofthouse, Andrew J.; Cummings, Russell M.] AIAA, Reston, VA 20191 USA.
RP Ghoreyshi, M (reprint author), US Air Force Acad, High Performance Comp Res Ctr, Colorado Springs, CO 80840 USA.; Ghoreyshi, M (reprint author), AIAA, Reston, VA 20191 USA.
NR 37
TC 0
Z9 0
U1 2
U2 2
PU AMER INST AERONAUTICS ASTRONAUTICS
PI RESTON
PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091-4344 USA
SN 0021-8669
EI 1533-3868
J9 J AIRCRAFT
JI J. Aircr.
PD NOV
PY 2016
VL 53
IS 6
BP 1802
EP 1820
DI 10.2514/1.C033763
PG 19
WC Engineering, Aerospace
SC Engineering
GA EF1PP
UT WOS:000390097300020
ER
PT J
AU Starnes, BW
Caps, MT
Arthurs, ZM
Tatum, B
Singh, N
AF Starnes, Benjamin W.
Caps, Michael T.
Arthurs, Zachary M.
Tatum, Billi
Singh, Niten
TI Evaluation of the learning curve for fenestrated endovascular aneurysm
repair
SO JOURNAL OF VASCULAR SURGERY
LA English
DT Article
ID JUXTARENAL AORTIC-ANEURYSMS; EXPERIENCE; GRAFTS
AB Objective: The objective of this study was to evaluate the learning curve for fenestrated endovascular aortic aneurysm repair (FEVAR).
Methods: Data were collected prospectively on all FEVAR procedures conducted by a single surgeon between June 2007 and January 2015. During the study period, 136 FEVARs were performed, and this experience was divided into four quartiles each consisting of 34 cases. Clinical outcomes evaluated included perioperative death and major complications. Process outcomes included length of procedure, fluoroscopy time, contrast material use, estimated blood loss, and intensive care unit length of stay.
Results: During the study period, there was a statistically significant increase in the complexity of cases as evidenced by an increase in the proportion of cases with two or more fenestrations from 52.9% in the first quartile to 88.2% in the fourth quartile (P =.001). Despite this, there was a steady decrease in the proportion of patients suffering perioperative death or major complications from 23.5% in the first quartile to 8.8% in the fourth quartile. After adjustment for potential confounding factors, the odds of death or major complication were cut by 52.4% per quartile increase (95% confidence interval [CI], 7.8%-75.5%; P =.028). In addition, among cases with two or more fenestrations, geometric mean length of procedure was reduced from 223.8 minutes in the first quartile to 149.6 minutes in the fourth quartile, and geometric mean fluoroscopy time was reduced from 58.6 minutes in the first quartile to 31.5 minutes in the fourth quartile. After adjustment, there was an estimated 9.9% reduction in geometric mean procedure length per quartile increase (95% CI, 3.5%-15.9%; P =.003) and a 17.6% reduction in geometric mean fluoroscopy time per quartile increase (95% CI, 10.9%-23.8%; P <.0001).
Conclusions: Despite an increase in case complexity, there was evidence for significant improvement in important clinical and process outcomes during the study period. We believe that much of this improvement was attributable to several key advances in the FEVAR procedure that were instituted during the study period and are discussed herein.
C1 [Starnes, Benjamin W.; Tatum, Billi; Singh, Niten] Univ Washington, Div Vasc Surg, Dept Surg, Seattle, WA 98195 USA.
[Caps, Michael T.] Kaiser Permanente, Honolulu, HI USA.
[Arthurs, Zachary M.] Brooke Army Med Ctr, San Antonio, TX USA.
RP Starnes, BW (reprint author), Univ Washington, Vasc Surg, 325 Ninth Ave, Seattle, WA 98104 USA.; Starnes, BW (reprint author), Univ Washington, Div Vasc Surg, 325 Ninth Ave, Seattle, WA 98104 USA.
EM starnes@uw.edu
NR 12
TC 0
Z9 0
U1 0
U2 0
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0741-5214
J9 J VASC SURG
JI J. Vasc. Surg.
PD NOV
PY 2016
VL 64
IS 5
BP 1219
EP 1227
DI 10.1016/j.jvs.2016.04.049
PG 9
WC Surgery; Peripheral Vascular Disease
SC Surgery; Cardiovascular System & Cardiology
GA EF0UQ
UT WOS:000390042100004
PM 27575815
ER
PT J
AU Mase, VJ
Roe, JL
Christy, RJ
Dubick, MA
Walters, TJ
AF Mase, Vincent J., Jr.
Roe, Janet L.
Christy, Robert J.
Dubick, Michael A.
Walters, Thomas J.
TI Postischemic conditioning does not reduce muscle injury after
tourniquet-induced ischemia-reperfusion injury in rats
SO AMERICAN JOURNAL OF EMERGENCY MEDICINE
LA English
DT Article
ID PROTECTS SKELETAL-MUSCLE; MITOCHONDRIAL-FUNCTION; IRAQI FREEDOM; LIMB
TRAUMA; REMOTE; ATTENUATION; INHIBITION; DEATH
AB Background: The widespread application of tourniquets has reduced battlefield mortality related to extremity exsanguinations. Tourniquet-induced ischemia-reperfusion injury (I/R) can contribute to muscle loss. Postischemic conditioning (PostC) confers protection against I/R in cardiac muscle and skeletal muscle flaps. The objective of this study was to determine the effect of PostC on extremity muscle viability in an established rat hindlimb tourniquet model.
Methods: Rats were randomly assigned to PostC-1, PostC-2, or no conditioning ischemic groups (n = 10 per group). Postischemic conditioning, performed immediately after tourniquet release, consisted of four 15-second cycles (PostC-1) or eight 15-second cycles (PostC-2) of alternating occlusion and perfusion of hindlimbs. Twenty-four hours later, muscles were excised. The primary end points were muscle edema and viability; secondary end points were histologic and markers of oxidative stress.
Results: Ischemia-reperfusion injury decreased viability in all tourniquet limbs, but viability was not improved in either PostC group. Likewise, I/R resulted in substantial muscle edema that was not reduced by PostC. The predominant histologic feature was necrosis, but no significant differences were found among groups. Markers of oxidative stress were increased similarly among groups after I/R, although myeloperoxidase activity was significantly increased only in the no conditioning ischemic group. A protective effect from PostC was not observed in our model suggesting that PostC was not effective in reducing I/R skeletal muscle injury or any benefits of PostC were not sustained for 24 hours when tissues were assessed.
Conclusion: These negative findings are pertinent as the military investigates different strategies to extend the safe time for tourniquet application. Published by Elsevier Inc.
C1 [Mase, Vincent J., Jr.; Roe, Janet L.; Christy, Robert J.; Walters, Thomas J.] US Army, Inst Surg Res, Extrem Trauma Res Program, San Antonio, TX 78234 USA.
[Dubick, Michael A.] US Army, Inst Surg Res, Damage Control Resuscitat Res Program, San Antonio, TX 78234 USA.
RP Walters, TJ (reprint author), US Army, Inst Surg Res, Extrem Trauma & Regenerat Med Res Program, San Antonio, TX 78234 USA.
EM vincent.j.mase.mil@mail.mil; janet.l.roe.civ@mail.mil;
robert.j.christy12.civ@mail.mil; michael.a.dubick.civ@mail.mil;
thomas.j.walters22.civ@mail.mil
FU US Army Medical Research and Medical Command [F_025_2010_USAISR]
FX This work was funded by the US Army Medical Research and Medical Command
(grant: F_025_2010_USAISR) awarded to TJW.
NR 43
TC 0
Z9 0
U1 2
U2 2
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0735-6757
EI 1532-8171
J9 AM J EMERG MED
JI Am. J. Emerg. Med.
PD NOV
PY 2016
VL 34
IS 11
BP 2065
EP 2069
DI 10.1016/j.ajem.2016.04.021
PG 5
WC Emergency Medicine
SC Emergency Medicine
GA EE3SD
UT WOS:000389517200002
PM 27614371
ER
PT J
AU Martin, KD
Patterson, DP
Cameron, KL
AF Martin, Kevin D.
Patterson, David P.
Cameron, Kenneth L.
TI Arthroscopic Training Courses Improve Trainee Arthroscopy Skills: A
Simulation-Based Prospective Trial
SO ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY
LA English
DT Article
ID VIRTUAL-REALITY SIMULATOR; SHOULDER ARTHROSCOPY; PERFORMANCE; EXPERIENCE
AB Purpose: To evaluate the correlation between timed task performance on an arthroscopy shoulder simulator and participation in a standardized expert shoulder arthroscopy educational course. Methods: Orthopaedic trainees were voluntarily recruited from over 25 residency programs throughout the United States and Canada. Each trainee was tested on arrival at the Arthroscopy Association of North America orthopaedic learning center on a virtual reality arthroscopy shoulder simulator, and his or her performance was objectively scored. Each trainee's postgraduate year level was recorded, as was his or her experience in residency with shoulder arthroscopy as measured by Accreditation Council for Graduate Medical Education case-log totals. After the focused 4-day training curriculum consisting of didactics and cadaveric experience, each trainee was re-evaluated on the same simulator. Statistical analysis was performed to determine if participation in the course was associated with changes in simulation performance from before to after assessment. Results: Forty-eight trainees completed the testing. On completion of the course, trainees showed significant improvements in all objective measures recorded by the simulator. Total probe distance needed to complete the task decreased by 42% (from 420.4 mm to 245.3 mm, P < .001), arthroscope tip distance traveled decreased by 59% (from 194.1 mm to 80.2 mm, P < .001), and time to completion decreased by 38% (from 66.8 seconds to 41.6 seconds, P < .001). Highly significant improvements in all 3 measures suggest improved instrument handling, anatomic recognition, and arthroscopy-related visual-spatial ability. Conclusions: This study shows objective improvement in orthopaedic trainee basic arthroscopy skill and proficiency after a standardized 4-day arthroscopy training curriculum. The results validate the Arthroscopy Association of North America resident training course and its curriculum with objective evidence of benefit.
C1 [Martin, Kevin D.] Evans Army Community Hosp, 1650 Cochrane Cir, Ft Carson, CO 80913 USA.
[Patterson, David P.] Detroit Med Ctr, DMC Sports Med, Detroit, MI USA.
[Cameron, Kenneth L.] US Mil Acad, Keller Army Hosp, West Point, NY 10996 USA.
RP Martin, KD (reprint author), Evans Army Community Hosp, 1650 Cochrane Cir, Ft Carson, CO 80913 USA.
EM Dr.kevin.d.martin@gmail.com
FU Department of Defense, US Army; Arthroscopic Association of North
America
FX The authors report the following potential conflict of interest or
source of funding: K.D.M. receives support from Department of Defense,
US Army. This project was supported by an educational grant from the
Arthroscopic Association of North America and has not been presented.
NR 15
TC 0
Z9 0
U1 1
U2 1
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0749-8063
EI 1526-3231
J9 ARTHROSCOPY
JI Arthroscopy
PD NOV
PY 2016
VL 32
IS 11
BP 2228
EP 2232
DI 10.1016/j.arthro.2016.03.026
PG 5
WC Orthopedics; Surgery
SC Orthopedics; Surgery
GA EE3SR
UT WOS:000389519200009
PM 27234652
ER
PT J
AU Dutton, JR
Kusenzov, NA
Lanzi, JT
Garcia, EJ
Pallis, MP
AF Dutton, Jason R.
Kusenzov, Nicholas A.
Lanzi, Joseph T.
Garcia, E'Stephan J.
Pallis, Mark P.
TI The Success of Hip Arthroscopy in an Active Duty Population
SO ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY
LA English
DT Article
ID FEMOROACETABULAR IMPINGEMENT; FOLLOW-UP; RETURN; OSTEOPLASTY;
DEBRIDEMENT; MANAGEMENT; DISABILITY; SPORTS
AB Purpose: To examine the outcomes of arthroscopic treatment of the hip in a young, active military population. Specifically, the ability to return to duty was the prime indicator of success. In addition, an objective evaluation of various demographic and surgery-related variables was performed to identify predictors for success or failure of treatment in this military population. Methods: A retrospective chart review was undertaken to ascertain the results of hip arthroscopy at a single academic military medical center. A total of 206 patients underwent 223 hip arthroscopies during a 13-year period (2000-2013). Of these, 159 patients met the inclusion criteria, which included active duty military service and at least 12-month follow-up. Veterans Affairs Beneficiaries, active duty dependents, and those with less than 12 months of follow-up were excluded. Surgeries were performed by 1 of 5 fellowship-trained orthopaedic surgeons. Data were collected from the Armed Forces Health Longitudinal Technology Application, Electronic profiling system, and Physical Evaluation Board. Results: A total of 159 patients were available for the study, 102 males and 57 females. The average age of the patients overall was 30.9 +/- 8.3 years (range, 18-52 years). Junior enlisted, which is considered entry level, made up 64.2% of the subjects. The most common diagnosis was femoroacetabular impingement, and the most common procedure performed was acetabuloplasty. Twenty-two percent of patients underwent evaluation by the medical retention board after hip arthroscopy and were separated from military service. Seventy-eight percent of soldiers were maintained on active duty after hip arthroscopy. The overall complication rate was 15.7%, with a major complication rate of 1.25% defined as femoral neck fracture, abdominal compartment syndrome, osteonecrosis, deep vein thrombosis and/or pulmonary embolus, and septic arthritis. Univariate analysis of risk factors showed the presence of a complication to be a significant predictor for failure to return to active duty (odds ratio [OR] 4.04, P =.0035) as was senior noncommissioned officer rank (OR 0.20, P =.0347). Multivariate analysis showed only the presence of a complication to be a significant predictor for failure to return to active duty (OR 3.71, P =.0083). Conclusions: Hip arthroscopy in a military population is effective in treating multiple causes and retaining soldiers on active duty status. Complications of any kind from surgery or postoperatively are significant predictors of medical separation and may warrant earlier initiation of a medical evaluation board.
C1 [Kusenzov, Nicholas A.; Lanzi, Joseph T.; Pallis, Mark P.] William Beaumont Army Med Ctr, Dept Orthoped Surg & Rehabil, El Paso, TX 79920 USA.
[Dutton, Jason R.] Irwin Army Community Hosp, Dept Surg, Ft Riley, KS USA.
[Garcia, E'Stephan J.] Keller Army Community Hosp, Dept Surg, West Point, NY USA.
RP Dutton, JR (reprint author), Irwin Army Community Hosp, 600 Caisson Rd, Ft Riley, KS 66542 USA.
EM jason.r.dutton.mil@mail.mil
FU Johnson and Johnson; AAOS Board of Councilors; Stryker; Cayenne
FX The authors report the following potential conflict of interest or
source of funding: M.P.P. receives support from Johnson and Johnson and
AAOS Board of Councilors. J.T.L. receives support from Stryker and
Cayenne.
NR 24
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U1 0
U2 0
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0749-8063
EI 1526-3231
J9 ARTHROSCOPY
JI Arthroscopy
PD NOV
PY 2016
VL 32
IS 11
BP 2251
EP 2258
DI 10.1016/j.arthro.2016.05.042
PG 8
WC Orthopedics; Surgery
SC Orthopedics; Surgery
GA EE3SR
UT WOS:000389519200014
PM 27567322
ER
PT J
AU Wu, D
Lawhern, VJ
Hairston, WD
Lance, BJ
AF Wu, Dongrui
Lawhern, Vernon J.
Hairston, W. David
Lance, Brent J.
TI Switching EEG Headsets Made Easy: Reducing Offline Calibration Effort
Using Active Weighted Adaptation Regularization
SO IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
LA English
DT Article
DE Active learning; active transfer learning; active weighted adaptation
regularization; domain adaptation; electroencephalography (EEG);
event-related potential; single-trial classification; transfer learning;
visual evoked potential; weighted adaptation regularization
ID SUBJECT TRANSFER; FRAMEWORK; CLASSIFICATION; EXAMPLES; BCI
AB Electroencephalography (EEG) headsets are the most commonly used sensing devices for brain-computer interface. In real-world applications, there are advantages to extrapolating data from one user session to another. However, these advantages are limited if the data arise from different hardware systems, which often vary between application spaces. Currently, this creates a need to recalibrate classifiers, which negatively affects people's interest in using such systems. In this paper, we employ active weighted adaptation regularization (AwAR), which integrates weighted adaptation regularization (wAR) and active learning, to expedite the calibration process. wAR makes use of labeled data from the previous headset and handles class-imbalance, and active learning selects the most informative samples from the new headset to label. Experiments on single-trial event-related potential classification show that AwAR can significantly increase the classification accuracy, given the same number of labeled samples from the new headset. In other words, AwAR can effectively reduce the number of labeled samples required from the new headset, given a desired classification accuracy, suggesting value in collating data for use in wide scale transfer-learning applications.
C1 [Wu, Dongrui] DataNova, Clifton Pk, NY 12065 USA.
[Lawhern, Vernon J.; Hairston, W. David; Lance, Brent J.] US Army Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD 20783 USA.
[Lawhern, Vernon J.] Univ Texas San Antonio, Dept Comp Sci, San Antonio, TX 78249 USA.
RP Wu, D (reprint author), DataNova, Clifton Pk, NY 12065 USA.
EM drwu09@gmail.com; vernon.j.lawhern.civ@mail.mil;
william.d.hairston4.civ@mail.mil; brent.j.lance.civ@mail.mil
FU U.S. Army Research Laboratory [W911NF-10-2-0022, W911NF-10-D-0002/TO
0023]
FX Research was sponsored by the U.S. Army Research Laboratory and was
accomplished under Cooperative Agreement Numbers W911NF-10-2-0022 and
W911NF-10-D-0002/TO 0023. The views and the conclusions contained in
this document are those of the authors and should not be interpreted as
representing the official policies, either expressed or implied, of the
U.S. Army Research Laboratory or the U.S. Government.
NR 57
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U1 3
U2 3
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 1534-4320
EI 1558-0210
J9 IEEE T NEUR SYS REH
JI IEEE Trans. Neural Syst. Rehabil. Eng.
PD NOV
PY 2016
VL 24
IS 11
BP 1125
EP 1137
DI 10.1109/TNSRE.2016.2544108
PG 13
WC Engineering, Biomedical; Rehabilitation
SC Engineering; Rehabilitation
GA EE1MH
UT WOS:000389345500001
ER
PT J
AU Geers, AL
Helfer, SG
Brown, JA
Brinol, P
AF Geers, A. L.
Helfer, S. G.
Brown, J. A.
Brinol, P.
TI WHEN DO PLACEBO EFFECTS ENDURE OVER TIME? TESTING THE ROLE OF COGNITIVE
ELABORATION
SO INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE
LA English
DT Meeting Abstract
C1 [Geers, A. L.] Univ Toledo, 2801 W Bancroft St, Toledo, OH 43606 USA.
[Helfer, S. G.] Adrian Coll, Adrian, MI USA.
[Brown, J. A.] US Army Publ Hlth Command, Bethesda, MD USA.
[Brinol, P.] Univ Autonoma Madrid, Madrid, Spain.
EM andrew.geers@utoledo.edu
NR 0
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1070-5503
EI 1532-7558
J9 INT J BEHAV MED
JI Int. J. Behav. Med.
PD NOV
PY 2016
VL 23
SU 1
MA S404
BP S131
EP S131
PG 1
WC Psychology, Clinical
SC Psychology
GA ED6CV
UT WOS:000388943400416
ER
PT J
AU Smith, TJ
Wilson, MA
Karl, JP
Austin, K
Bukhari, A
Pasiakos, SM
O'Connor, KL
Lieberman, HR
AF Smith, Tracey J.
Wilson, Marques A.
Karl, J. Philip
Austin, Krista
Bukhari, Asma
Pasiakos, Stefan M.
O'Connor, Kristie L.
Lieberman, Harris R.
TI Interstitial glucose concentrations and hypoglycemia during 2 days of
caloric deficit and sustained exercise: a double-blind,
placebo-controlled trial
SO JOURNAL OF APPLIED PHYSIOLOGY
LA English
DT Article
DE caloric restriction; glycemia; interstitial glucose; energy deficit;
continuous glucose measurement
ID RAPID WEIGHT-LOSS; COMBINED PROLONGED EXERCISE; LOW-GLYCEMIC INDEX;
PHYSICAL PERFORMANCE; MONITORING-SYSTEM; BLOOD-GLUCOSE;
ENERGY-REQUIREMENTS; COGNITIVE FUNCTION; INSULIN RESPONSES;
PLASMA-GLUCOSE
AB Military personnel and some athlete populations endure short-term energy deficits from reduced energy intake and/or increased energy expenditure (EE) that may degrade physical and cognitive performance due to severe hypoglycemia (<3.1 mmol/l). The extent to which energy deficits alter normoglycemia (3.9-7.8 mmol/l) in healthy individuals is not known, since prior studies measured glucose infrequently, not continuously. The purpose of this study was to characterize the glycemic response to acute, severe energy deficit compared with fully fed control condition, using continuous glucose monitoring (CGM). For 2 days during a double-blind, placebo-controlled, crossover study, 23 volunteers (17 men/6 women; age: 21.3 +/- 3.0 yr; body mass index: 25 +/- 3 kg/m) increased habitual daily EE [2,300 +/- 450 kcal/day [means +/- SD)] by 1,647 +/- 345 kcal/ day through prescribed exercise (similar to 3 h/day; 40-65% peak O-2 consumption), and consumed diets designed to maintain energy balance (FED) or induce 93% energy deficit (DEF). Interstitial glucose concentrations were measured continuously by CGM (Medtronic Minimed). Interstitial glucose concentrations were 1.0 +/- 0.9 mmol/l lower during DEF vs. FED (P < 0.0001). The percentage of time spent in mild (3.1-3.8 mmol/l) hypoglycemia was higher during DEF compared with FED [mean difference = 20.5%; 95% confidence interval (CI): 13.1%, 27.9%; P = 0.04], while time spent in severe (<3.1 mmol/l) hypoglycemia was not different between interventions (mean difference = 4.6%; 95% CI:-0.6%, 9.8%; P = 0.10). Three of 23 participants spontaneously reported symptoms (e.g., nausea) potentially related to hypoglycemia during DEF, and an additional participant reported symptoms during both interventions. These findings suggest that severe hypoglycemia rarely occurs in healthy individuals enduring severe, short-term energy deficit secondary to heavy exercise and inadequate energy intake.
C1 [Smith, Tracey J.; Wilson, Marques A.; Karl, J. Philip; Austin, Krista; Bukhari, Asma; Pasiakos, Stefan M.; O'Connor, Kristie L.; Lieberman, Harris R.] US Army, Mil Nutr Div, Environm Med Res Inst, 10 Gen Greene Ave,Bldg 42, Natick, MA 01760 USA.
RP Smith, TJ (reprint author), US Army, Mil Nutr Div, Environm Med Res Inst, 10 Gen Greene Ave,Bldg 42, Natick, MA 01760 USA.
EM Tracey.smith10.civ@mail.mil
RI Pasiakos, Stefan/E-6295-2014
OI Pasiakos, Stefan/0000-0002-5378-5820
FU US Department of Energy; USARIEM
FX This research was supported in part by an appointment to the
Postgraduate Research Participation Program at the US Army Research
Institute of Environmental Medicine (USARIEM), administered by the Oak
Ridge Institute for Science and Education through an interagency
agreement between the US Department of Energy and USARIEM.
NR 60
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U1 3
U2 3
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 8750-7587
EI 1522-1601
J9 J APPL PHYSIOL
JI J. Appl. Physiol.
PD NOV 1
PY 2016
VL 121
IS 5
BP 1208
EP 1216
DI 10.1152/japplphysiol.00432.2016
PG 9
WC Physiology; Sport Sciences
SC Physiology; Sport Sciences
GA EE5MH
UT WOS:000389651700020
PM 27687559
ER
PT J
AU Ubalee, R
Kim, HC
Schuster, AL
McCardle, PW
Phasomkusolsil, S
Takhampunya, R
Davidson, SA
Lee, WJ
Klein, TA
AF Ubalee, Ratawan
Kim, Heung-Chul
Schuster, Anthony L.
McCardle, Patrick W.
Phasomkusolsil, Siriporn
Takhampunya, Ratree
Davidson, Silas A.
Lee, Won-Ja
Klein, Terry A.
TI Vector Competence of Anopheles kleini and Anopheles sinensis (Diptera:
Culicidae) From the Republic of Korea to Vivax Malaria-Infected Blood
From Patients From Thailand
SO JOURNAL OF MEDICAL ENTOMOLOGY
LA English
DT Article
DE Vivax malaria; Anopheles mosquito; epidemiology; Republic of Korea
ID MOSQUITO SPECIES COMPOSITION; MICROSATELLITE DNA ANALYSIS;
PLASMODIUM-VIVAX; SOUTH-KOREA; DEMILITARIZED ZONE; HYRCANUS GROUP;
SALIVARY-GLANDS; LARVAL HABITATS; US FORCES; PARASITES
AB In total, 1,300 each of Anopheles kleini Rueda and Anopheles sinensis Wiedemann sensu stricto (s.s.) females (colonized from the Republic of Korea) and Anopheles dirus Peyton & Harrison (Thai strain) were allowed to feed on blood from Thai malaria patients naturally infected with Plasmodium vivax. The overall oocyst infection rates for An. dirus, An. kleini, and An. sinensis s.s. were 77.4, 46.1, and 45.9%, respectively. The mean number of oocysts was significantly higher for An. dirus (82.7) compared with An. kleini (6.1) and An. sinensis s.s. (8.6), whereas the mean number of oocysts for An. kleini and An. sinensis s.s. was similar. The overall sporozoite infection rates for An. dirus, An. kleini, and An. sinensis s.s. dissected on days 14-15, 21, and 28 days post-feed were significantly higher for An. dirus (90.0%) than An. kleini (5.4%), whereas An. kleini sporozoite rates were significantly higher than An. sinensis s.s. (<0.1%). The overall sporozoite indices for positive females with +3 (100-1,000 sporozoites) and +4 (>1,000 sporozoites) salivary gland indices were significantly higher for An. dirus (85.7%), compared with An. kleini (47.1%). Only one An. sinensis s.s. had sporozoites (+2;>10-100 sporozoites). These results indicate that An. kleini is a competent vector of vivax malaria. Although An. sinensis s. s. develops relatively high numbers of oocysts, it is considered a very poor vector of vivax malaria due to a salivary gland barrier.
C1 [Ubalee, Ratawan; Schuster, Anthony L.; McCardle, Patrick W.; Phasomkusolsil, Siriporn; Takhampunya, Ratree; Davidson, Silas A.] US Army Med Component, Dept Entomol, Armed Forces Res Inst Med Sci, 315-6 Rajvithi, Bangkok 10400, Thailand.
[Kim, Heung-Chul] 5th Med Detachment,168th Multifunct Med Battal, APO, AP 96205 USA.
[Schuster, Anthony L.] Prevent Hlth Serv Off, Ft Sam Houston, TX 78234 USA.
[McCardle, Patrick W.] Walter Reed Army Inst Res, Forest Glen, MD 20910 USA.
[Lee, Won-Ja] Korea Natl Inst Hlth, Cheongju 28159, Chungbuk Provin, South Korea.
[Klein, Terry A.] Med Dept Act Korea MEDDAC K, 65th Med Brigade,Unit 15281,Box 754, APO, AP 96205 USA.
RP Ubalee, R (reprint author), US Army Med Component, Dept Entomol, Armed Forces Res Inst Med Sci, 315-6 Rajvithi, Bangkok 10400, Thailand.
EM ratawanu.fsn@afrims.org; hungchol.kim2.ln@mail.mil;
Anthony.l.schuster.mil@mail.mil; Patrick.w.mccardle.mil@mail.mil;
SiripornP.fsn@afrims.org; RatreeT.fsn@afrims.org;
Silas.Davidson.mil@afrims.org; leewonja@gmail.com;
terry.a.klein2.civ@mail.mil
FU Armed Forces Health Surveillance Branch, Global Emerging Infections
Surveillance and Response System (AFHSB-GEIS), Silver Spring, MD; Public
Health Command District-Korea (Provisional), Camp Humphreys, ROK; 65th
Medical Brigade, Yongsan USAG, ROK
FX We thank members of the Mae Sod Malaria Clinic, Mae Sod District, and
Thailand Ministry of Public Health for their support. Funding for
portions of this work was provided by the Armed Forces Health
Surveillance Branch, Global Emerging Infections Surveillance and
Response System (AFHSB-GEIS), Silver Spring, MD, the Public Health
Command District-Korea (Provisional), Camp Humphreys, ROK, and the 65th
Medical Brigade, Yongsan USAG, ROK. The opinions expressed herein are
those of the authors and are not to be construed as official or
reflecting the views of the U.S. Department of the Army, Department of
Defence, or the U.S. Government.
NR 91
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U1 1
U2 1
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0022-2585
EI 1938-2928
J9 J MED ENTOMOL
JI J. Med. Entomol.
PD NOV
PY 2016
VL 53
IS 6
BP 1425
EP 1432
DI 10.1093/jme/tjw109
PG 8
WC Entomology; Veterinary Sciences
SC Entomology; Veterinary Sciences
GA EF3IH
UT WOS:000390217500023
PM 27493248
ER
PT J
AU Sanamyan, T
AF Sanamyan, Tigran
TI Efficient cryogenic mid-IR and eye-safe Er:YAG laser
SO JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICS
LA English
DT Article
ID 2.79 MU-M; CERAMIC LASER; ENERGY-LEVELS; FIBER LASER; NM; TEMPERATURE;
CRYSTALS; LEVEL; IONS
AB We report the first diode-pumped, continuous-wave cascaded dual-wavelength operation of an Er3+:YAG cryogenic laser emitting simultaneously at similar to mid-IR 2.7 and eye-safe 1.6 mu m. The laser is capable of delivering 45 and 10Wat 1.62 and 2.73 mu m wavelength, with slope efficiencies similar to 15% and 55%, respectively. The overall efficiency with respect to the absorbed similar to 960 nm pump power was 71%. Detailed analysis of the output power, efficiency, wavelengths, and relevant spectroscopic data is also presented. (C) 2016 Optical Society of America
C1 [Sanamyan, Tigran] US Army Res Lab, RDRL SEE L, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
RP Sanamyan, T (reprint author), US Army Res Lab, RDRL SEE L, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM tigran.sanamyan.civ@mail.mil
FU Army Research Laboratory (ARL) Sensors and Electron Devices Directorate
FX Army Research Laboratory (ARL) Sensors and Electron Devices Directorate.
NR 24
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U1 8
U2 8
PU OPTICAL SOC AMER
PI WASHINGTON
PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA
SN 0740-3224
EI 1520-8540
J9 J OPT SOC AM B
JI J. Opt. Soc. Am. B-Opt. Phys.
PD NOV 1
PY 2016
VL 33
IS 11
BP D1
EP D6
DI 10.1364/JOSAB.33.0000D1
PG 6
WC Optics
SC Optics
GA EC0CW
UT WOS:000387766500002
ER
PT J
AU Sarkes, DA
Hurley, MM
Stratis-Cullum, DN
AF Sarkes, Deborah A.
Hurley, Margaret M.
Stratis-Cullum, Dimitra N.
TI Unraveling the Roots of Selectivity of Peptide Affinity Reagents for
Structurally Similar Ribosomal Inactivating Protein Derivatives
SO MOLECULES
LA English
DT Article
DE bacterial display; biopanning; peptide; abrin; RIPs; biosensing; toxin;
XPairIt; molecular modeling; docking
ID RICIN A-CHAIN; BACTERIAL DISPLAY; MOLECULAR-DYNAMICS; PHAGE DISPLAY;
IN-VITRO; ABRIN-A; BINDING; VACCINE; EPITOPE; ELECTROSTATICS
AB Peptide capture agents have become increasingly useful tools for a variety of sensing applications due to their ease of discovery, stability, and robustness. Despite the ability to rapidly discover candidates through biopanning bacterial display libraries and easily mature them to Protein Catalyzed Capture (PCC) agents with even higher affinity and selectivity, an ongoing challenge and critical selection criteria is that the peptide candidates and final reagent be selective enough to replace antibodies, the gold-standard across immunoassay platforms. Here, we have discovered peptide affinity reagents against abrax, a derivative of abrin with reduced toxicity. Using on-cell Fluorescence Activated Cell Sorting (FACS) assays, we show that the peptides are highly selective for abrax over RiVax, a similar derivative of ricin originally designed as a vaccine, with significant structural homology to abrax. We rank the newly discovered peptides for strongest affinity and analyze three observed consensus sequences with varying affinity and specificity. The strongest (Tier 1) consensus was FWDTWF, which is highly aromatic and hydrophobic. To better understand the observed selectivity, we use the XPairIt peptide-protein docking protocol to analyze binding location predictions of the individual Tier 1 peptides and consensus on abrax and RiVax. The binding location profiles on the two proteins are quite distinct, which we determine is due to differences in pocket size, pocket environment (including hydrophobicity and electronegativity), and steric hindrance. This study provides a model system to show that peptide capture candidates can be quite selective for a structurally similar protein system, even without further maturation, and offers an in silico method of analysis for understanding binding and down-selecting candidates.
C1 [Sarkes, Deborah A.; Hurley, Margaret M.; Stratis-Cullum, Dimitra N.] US Army, Biotechnol Branch, Sensors & Electron Devices Directorate, Res Lab, Adelphi, MD 20783 USA.
RP Sarkes, DA (reprint author), US Army, Biotechnol Branch, Sensors & Electron Devices Directorate, Res Lab, Adelphi, MD 20783 USA.
EM deborah.a.sarkes.civ@mail.mil; margaret.m.hurley12.civ@mail.mil;
dimitra.n.stratis-cullum.civ@mail.mil
FU US Army Research Laboratory Sensors and Electron Devices Directorate
FX This project was supported by the US Army Research Laboratory Sensors
and Electron Devices Directorate. Plasmids for expression of abrax and
RiVax were kindly provided by Alena Calm of Edgewood Chemical Biological
Center. The eCPX 3.0 bacterial display library was obtained through a
collaboration with Patrick Daugherty at the University of California,
Santa Barbara. The authors would like to thank Matthew Coppock for
helpful discussions for this project and future directions, Qin Guo for
laboratory technician support of preliminary experiments, and Drs.
Matthew Coppock and Jessica Terrell for their time proofreading the
manuscript.
NR 80
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U1 0
U2 0
PU MDPI AG
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1420-3049
J9 MOLECULES
JI Molecules
PD NOV
PY 2016
VL 21
IS 11
AR 1504
DI 10.3390/molecules21111504
PG 19
WC Chemistry, Organic
SC Chemistry
GA EE9AO
UT WOS:000389918200086
ER
PT J
AU Yu, YH
Chen, SH
Chang, CL
Lin, CT
Hairston, WD
Mrozek, RA
AF Yu, Yi-Hsin
Chen, Shih-Hsun
Chang, Che-Lun
Lin, Chin-Teng
Hairston, W. David
Mrozek, Randy A.
TI New Flexible Silicone-Based EEG Dry Sensor Material Compositions
Exhibiting Improvements in Lifespan, Conductivity, and Reliability
SO SENSORS
LA English
DT Article
DE electroencephalography (EEG); scanning electron microscope (SEM);
silicone-based dry sensors
ID INTEGRATION; SYSTEM
AB This study investigates alternative material compositions for flexible silicone-based dry electroencephalography (EEG) electrodes to improve the performance lifespan while maintaining high-fidelity transmission of EEG signals. Electrode materials were fabricated with varying concentrations of silver-coated silica and silver flakes to evaluate their electrical, mechanical, and EEG transmission performance. Scanning electron microscope (SEM) analysis of the initial electrode development identified some weak points in the sensors' construction, including particle pull-out and ablation of the silver coating on the silica filler. The newly-developed sensor materials achieved significant improvement in EEG measurements while maintaining the advantages of previous silicone-based electrodes, including flexibility and non-toxicity. The experimental results indicated that the proposed electrodes maintained suitable performance even after exposure to temperature fluctuations, 85% relative humidity, and enhanced corrosion conditions demonstrating improvements in the environmental stability. Fabricated flat (forehead) and acicular (hairy sites) electrodes composed of the optimum identified formulation exhibited low impedance and reliable EEG measurement; some initial human experiments demonstrate the feasibility of using these silicone-based electrodes for typical lab data collection applications.
C1 [Yu, Yi-Hsin] China Univ Technol, Dept Interact Entertainment Design, Taipei 11695, Taiwan.
[Chen, Shih-Hsun] Natl Taiwan Univ Sci & Technol, Dept Mech Engn, Taipei 10607, Taiwan.
[Chang, Che-Lun] Natl Chiao Tung Univ, Brain Res Ctr, Hsinchu 300, Taiwan.
[Lin, Chin-Teng] Univ Technol, Fac Engn & Informat Technol, Sydney, NSW 2007, Australia.
[Hairston, W. David] US Army Res Lab, Translat Neurosci Branch, Human Res & Engn Directorate, Adelphi, MD 20783 USA.
[Mrozek, Randy A.] US Army Res Lab, Macromol Sci & Technol Branch, Weap & Mat Res Directorate, Adelphi, MD 20783 USA.
RP Lin, CT (reprint author), Univ Technol, Fac Engn & Informat Technol, Sydney, NSW 2007, Australia.
EM ysyou0409@cute.edu.tw; shchen@mail.ntust.edu.tw; chelun@nctu.edu.tw;
Chin-Teng.Lin@uts.edu.au; william.d.hairston4.civ@mail.mil;
randy.a.mrozek.civ@mail.mil
FU UST-UCSD International Center of Excellence in Advanced Bio-engineering
- Taiwan Ministry of Science and Technology; Aiming for the Top
University Plan of National Chiao Tung University, the Ministry of
Education, Taiwan [104W963]; Australian Research Council (ARC)
[DP150101645]; U.S. Army Research Laboratory [W911NF-10-2-0022,
W911NF-10-D-0002/TO 0023]; [MOST 104-2627-E-009-001]
FX This work was supported in part by the UST-UCSD International Center of
Excellence in Advanced Bio-engineering sponsored by the Taiwan Ministry
of Science and Technology, in part by MOST 104-2627-E-009-001, in part
by the Aiming for the Top University Plan of National Chiao Tung
University, the Ministry of Education, Taiwan, under Contract 104W963.
Research was also sponsored by the Australian Research Council (ARC)
under discovery grant DP150101645, and by the U.S. Army Research
Laboratory under Cooperative Agreement Numbers W911NF-10-2-0022 and
W911NF-10-D-0002/TO 0023. The views and the conclusions contained in
this document are those of the authors and should not be interpreted as
representing the official policies, either expressed or implied, of the
Army Research Laboratory or the U.S Government. The U.S Government is
authorized to reproduce and distribute reprints for Government purposes
notwithstanding any copyright notation herein.
NR 29
TC 0
Z9 0
U1 3
U2 3
PU MDPI AG
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1424-8220
J9 SENSORS-BASEL
JI Sensors
PD NOV
PY 2016
VL 16
IS 11
AR 1826
DI 10.3390/s16111826
PG 17
WC Chemistry, Analytical; Electrochemistry; Instruments & Instrumentation
SC Chemistry; Electrochemistry; Instruments & Instrumentation
GA EE5JB
UT WOS:000389641700059
ER
PT J
AU Erhunmwunsee, L
Flanagan, RP
Jaquiss, RDB
Lodge, AJ
AF Erhunmwunsee, Loretta
Flanagan, Ryan P.
Jaquiss, Robert D. B.
Lodge, Andrew J.
TI Atrial Rhabdomyoma Resection With Extracellular Matrix Reconstruction of
the Right Atrial Free Wall in an Infant
SO WORLD JOURNAL FOR PEDIATRIC AND CONGENITAL HEART SURGERY
LA English
DT Article
DE rhabdomyoma; arrhythmia; extracellular matrix; tuberous sclerosis
ID CARDIAC TUMORS
AB A neonate was diagnosed with a mediastinal mass after presenting with bradycardia. At surgery, she was found to have a 4-cm mass replacing most of the right atrial free wall. After tumor resection, the right atrium was reconstructed with an extracellular matrix biomaterial that supports native tissue regeneration. Her pathology revealed rhabdomyoma, which is rare in patients without tuberous sclerosis. The procedure was well tolerated but was complicated by narrowing of the superior vena cava that required dilation postoperatively.
C1 [Erhunmwunsee, Loretta] City Hope Natl Med Ctr, Dept Surg, Div Thorac Surg, Duarte, CA USA.
[Flanagan, Ryan P.] Duke Univ, Med Ctr, Dept Surg, Div Cardiovasc & Thorac Surg, Box 3340, Durham, NC 27710 USA.
[Jaquiss, Robert D. B.; Lodge, Andrew J.] Womack Army Med Ctr, Dept Pediat, Div Pediat Cardiol, Ft Bragg, NC USA.
RP Lodge, AJ (reprint author), Duke Univ, Med Ctr, Dept Surg, Div Cardiovasc & Thorac Surg, Box 3340, Durham, NC 27710 USA.
EM andrew.lodge@dm.duke.edu
NR 8
TC 0
Z9 0
U1 1
U2 1
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 2150-1351
EI 2150-136X
J9 WORLD J PEDIATR CONG
JI World J. Pediatr. Congenit. Heart Surg.
PD NOV
PY 2016
VL 7
IS 6
BP 769
EP 772
DI 10.1177/2150135115610718
PG 4
WC Cardiac & Cardiovascular Systems
SC Cardiovascular System & Cardiology
GA EE9AB
UT WOS:000389916900019
PM 26993755
ER
PT J
AU Schlanser, JR
Bohart, GW
Paperd, DW
Wagner, C
Marquardt, M
Harrison, TM
AF Schlanser, Justin R.
Bohart, George W.
Paperd, Deborah W.
Wagner, Cynthia
Marquardt, Mark
Harrison, Tara M.
TI Technique for Venipuncture of the Transverse Facial Vein in the Black
Rhinoceros (Diceros bicornis)
SO ZOO BIOLOGY
LA English
DT Article
DE Diceros bicornis; transverse facial vein; black rhinoceros; venipuncture
ID VALUES
AB Through the use of operant conditioning, the authors developed a technique to facilitate obtaining blood samples from a black rhinoceros diagnosed with idiopathic epilepsy. The technique involved operant conditioning to facilitate venipuncture of the transverse facial vein, at an anatomic landmark on the lateral side of the face ventral to the medial canthus of the eye, and dorsal to the lateral commissure of the mouth. The investigators used standard operant conditioning protocols to train the animal for desensitization to a needle puncture in the facial vein. Blood samples obtained from the facial location were free of excessive hemolysis and allowed for large volumes to be collected. The procedure was well-tolerated by the rhinoceros and could be performed regularly without complication. (C) 2016 Wiley Periodicals, Inc.
C1 [Schlanser, Justin R.] US Army Publ Hlth Command, Ft Gordon, GA USA.
[Bohart, George W.] Michigan State Univ, Vet Teaching Hosp, E Lansing, MI 48824 USA.
[Paperd, Deborah W.; Wagner, Cynthia; Marquardt, Mark] Potter Pk Zoo, Lansing, MI USA.
[Harrison, Tara M.] North Carolina State Univ, Dept Clin Sci, Raleigh, NC 27607 USA.
RP Harrison, TM (reprint author), North Carolina State Univ, Dept Clin Sci, Raleigh, NC 27607 USA.
EM taramharrison@gmail.com
NR 8
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0733-3188
EI 1098-2361
J9 ZOO BIOL
JI Zoo Biol.
PD NOV-DEC
PY 2016
VL 35
IS 6
BP 570
EP 573
DI 10.1002/zoo.21317
PG 4
WC Veterinary Sciences; Zoology
SC Veterinary Sciences; Zoology
GA EE2VK
UT WOS:000389443000011
PM 27569067
ER
PT J
AU Snesrud, E
He, S
Chandler, M
Dekker, JP
Hickman, AB
McGann, P
Dyda, F
AF Snesrud, Erik
He, Susu
Chandler, Michael
Dekker, John P.
Hickman, Alison B.
McGann, Patrick
Dyda, Fred
TI A Model for Transposition of the Colistin Resistance Gene mcr-1 by
ISApl1
SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
LA English
DT Article
ID ESCHERICHIA-COLI; ELEMENT
AB Analysis of mcr-1-containing sequences identified a common similar to 2,607-bp DNA segment that in many cases is flanked on one or both ends by ISApl1. We present evidence that mcr-1 is mobilized by an ISApl1 composite transposon which has, in some cases, subsequently lost one or both copies of ISApl1. We also show that mcr-1 can be mobilized in some circumstances by a single upstream copy of ISApl1 in conjunction with the remnants of a downstream ISApl1.
C1 [Snesrud, Erik; McGann, Patrick] Walter Reed Army Inst Res, Multidrug Resistant Organism Repository & Surveil, Silver Spring, MD USA.
[He, Susu; Hickman, Alison B.; Dyda, Fred] NIDDK, Mol Biol Lab, NIH, Bethesda, MD USA.
[Chandler, Michael] CNRS, Lab Microbiol & Genet Mol, Toulouse, France.
[Dekker, John P.] NIH, Ctr Clin, Dept Lab Med, Microbiol Serv, Bldg 10, Bethesda, MD 20892 USA.
RP Dyda, F (reprint author), NIDDK, Mol Biol Lab, NIH, Bethesda, MD USA.
EM dyda@helix.nih.gov
FU HHS \ NIH \ National Institute of Diabetes and Digestive and Kidney
Diseases (NIDDK); Intramural Program of the National Institute of
Diabetes and Digestive and Kidney Diseases; NIH Clinical Center; U. S.
Army Medical Command; Global Emerging Infections Surveillance and
Response System; Defense Medical Research and Development Program
FX This work, including the efforts of Alison B. Hickman, was funded by HHS
vertical bar NIH vertical bar National Institute of Diabetes and
Digestive and Kidney Diseases (NIDDK).; This work was partially
supported by the Intramural Program of the National Institute of
Diabetes and Digestive and Kidney Diseases (S. H., A. B. H., and F. D.),
the NIH Clinical Center (J. P. D.), and the U. S. Army Medical Command,
the Global Emerging Infections Surveillance and Response System, and the
Defense Medical Research and Development Program (P. M. and E. S.).
NR 14
TC 2
Z9 2
U1 7
U2 7
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0066-4804
EI 1098-6596
J9 ANTIMICROB AGENTS CH
JI Antimicrob. Agents Chemother.
PD NOV
PY 2016
VL 60
IS 11
BP 6973
EP 6976
DI 10.1128/AAC.01457-16
PG 4
WC Microbiology; Pharmacology & Pharmacy
SC Microbiology; Pharmacology & Pharmacy
GA ED7QH
UT WOS:000389063500074
PM 27620479
ER
PT J
AU Kott, A
Swami, A
West, BJ
AF Kott, Alexander
Swami, Ananthram
West, Bruce J.
TI The Fog of War in Cyberspace
SO COMPUTER
LA English
DT Article
AB A "cyberfog" security approach that splits data into numerous fragments and continually disperses them across multiple end-user devices could provide greater attack resiliency but also presents formidable technical challenges.
C1 [Kott, Alexander] US Army Res Lab, Network Sci Div, Adelphi, MD 20783 USA.
[Swami, Ananthram] US Army Res Lab, Network Sci, Adelphi, MD USA.
[West, Bruce J.] US Army Res Lab, Informat Sci Directorate, Math, Army Res Off, Adelphi, MD USA.
RP Kott, A (reprint author), US Army Res Lab, Network Sci Div, Adelphi, MD 20783 USA.
EM alexander.kott1.civ@mail.mil; ananthram.swami.civ@mail.mil;
bruce.j.west.civ@mail.mil
NR 10
TC 0
Z9 0
U1 0
U2 0
PU IEEE COMPUTER SOC
PI LOS ALAMITOS
PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1314 USA
SN 0018-9162
EI 1558-0814
J9 COMPUTER
JI Computer
PD NOV
PY 2016
VL 49
IS 11
BP 84
EP 87
PG 4
WC Computer Science, Hardware & Architecture; Computer Science, Software
Engineering
SC Computer Science
GA ED4ZJ
UT WOS:000388860800013
ER
PT J
AU Legree, PJ
Mullins, HM
LaPort, KA
Roberts, RD
AF Legree, Peter J.
Mullins, Heather M.
LaPort, Kate A.
Roberts, Richard D.
TI SLODR-house rules: EI tests less g loaded in higher ability groups
SO INTELLIGENCE
LA English
DT Article
DE Emotional intelligence; MSCEIT; Spearman's Law of Diminishing Returns;
Profile similarity metrics
ID EMOTIONAL INTELLIGENCE; COGNITIVE-ABILITIES; JOB-PERFORMANCE; VALIDITY;
DIFFERENTIATION; MSCEIT; UTILITY; MODEL; IQ
AB Spearman's Law of Diminishing Returns (SLODR) refers to the finding that cognitive ability tests tend to be less correlated and less g loaded for higher ability samples than for lower ability samples. However, it has been unknown whether SLODR applies to the domain of emotional intelligence. Analyses document SLODR effects for the Mayer Salovey Caruso Emotional Intelligence Test (MSCEIT). These results suggest that reports of minimal g loadings for emotional intelligence batteries may have reflected the use of high ability samples. Broader conclusions suggest that g loadings for emerging ability domains should be based on data collected from broad cognitive ability samples because the use of higher ability samples will systematically underestimate g loadings and cannot be accurately corrected for direct range restriction. Published by Elsevier Inc.
C1 [Legree, Peter J.] US Army, Res Inst Behav & Social Sci, 6000 6th St Bldg 1464 Mail Stop 5610, Ft Belvoir, VA 22026 USA.
[Mullins, Heather M.] George Mason Univ, Fairfax, VA 22030 USA.
[LaPort, Kate A.] Aon Hewitt Human Capital Serv, Washington, DC USA.
[Roberts, Richard D.] Profess Examinat Serv, New York, NY USA.
RP Legree, PJ (reprint author), US Army, Res Inst Behav & Social Sci, 6000 6th St Bldg 1464 Mail Stop 5610, Ft Belvoir, VA 22026 USA.
EM Peter.J.Legree.Civ@Mail.Mil
FU U.S. Army Research Institute [W91WAW-07-C-0025]
FX The views, opinions, and findings contained in this article are solely
those of the authors and do not purport to represent the views of the
U.S. Army Research Institute for the Behavioral and Social Sciences,
George Mason University, Aon Hewitt Human Capital Services, or
Professional Examination Service. They should not be construed as an
official U.S. Department of the Army or U.S. Department of Defense
position, policy, or decision, unless so designated by other
documentation. This research was partially supported by U.S. Army
Research Institute Contract W91WAW-07-C-0025 to the Educational Testing
Service, who we thank for providing access to the data
NR 33
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0160-2896
EI 1873-7935
J9 INTELLIGENCE
JI Intelligence
PD NOV-DEC
PY 2016
VL 59
BP 32
EP 38
DI 10.1016/j.intell.2016.06.009
PG 7
WC Psychology, Multidisciplinary
SC Psychology
GA ED9CW
UT WOS:000389168800005
ER
PT J
AU Ligda, J
D'Antuono, DS
Taheri, ML
Schuster, BE
Wei, Q
AF Ligda, J.
D'Antuono, D. Scotto
Taheri, M. L.
Schuster, B. E.
Wei, Q.
TI Quasi-static Tensile and Compressive Behavior of Nanocrystalline
Tantalum based on Miniature Specimen Testing-Part I: Materials
Processing and Microstructure
SO JOM
LA English
DT Article
ID HIGH-PRESSURE TORSION; SEVERE PLASTIC-DEFORMATION; ATOMIC BOND
PARAMETERS; MECHANICAL-PROPERTIES; THIN-FILMS; DIFFRACTION SPECTRA;
GRAIN-REFINEMENT; TEXTURE ANALYSIS; SHEAR BANDS; PURE METALS
AB Grain size reduction of metals into ultrafine-grained (UFG, grain size 100 nm < d < 1000 nm) and nanocrystalline (NC, d < 100 nm) regimes results in considerable increase in strength along with other changes in mechanical behavior such as vanishing strain hardening and limited ductility. Severe plastic deformation (SPD) has been among the favored technologies for the fabrication of UFG/NC metals. Primary past research efforts on SPD UFG/NC metals have been focused on easy-to-work metals, especially face-centered cubic metals such as copper, nickel, etc., and the limited efforts on body-centered cubic metals have mainly focused on high strain rate behavior where these metals are shown to deform via adiabatic shear bands. Except for the work on Fe, only a few papers can be found associated with UFG/NC refractory metals. In the first part of the present work (Part I), high-pressure torsion (HPT) is used to process UFG/NC tantalum, a typical refractory metal. The microstructure of the HPT disk as a function of radial location as well as orientation will be examined. In the subsequent part (Part II), the location-specific mechanical behavior will be presented and discussed. It is suggested that refractory metals such as Ta are ideal to employ SPD technology for microstructure refinement because of the extremely high melting point and relatively good workability.
C1 [Ligda, J.] Univ North Carolina Charlotte, PhD Program Nanoscale Sci & Technol, Charlotte, NC 28223 USA.
[Ligda, J.; Schuster, B. E.] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA.
[D'Antuono, D. Scotto; Taheri, M. L.] Drexel Univ, Dept Mat Sci, Philadelphia, PA 19104 USA.
[Wei, Q.] Univ North Carolina Charlotte, Dept Mech Engn, Charlotte, NC 28223 USA.
RP Wei, Q (reprint author), Univ North Carolina Charlotte, Dept Mech Engn, Charlotte, NC 28223 USA.
EM qwei@uncc.edu
RI Wei, Qiuming/B-7579-2008
FU US Army Research Laboratory [W911QX-06-C-0124, W911QX-08-C-0073]; U.S.
Department of Energy (DOE) Office of Science; U.S. DOE
[DE-AC02-06CH11357]; United States Department of Energy Basic Energy
Sciences (DOE/BES) [DE-SC0008274]; Office of Naval Research
[N000141210505]; Department of Energy's Nuclear Energy University
Program [NE0000315]
FX We would like to thank Professor Ruslan Valiev for performing
high-pressure torsion on the Ta disk and Dr. Shailendra Joshi for
discussions on the grain rotation theory. Q. Wei would like to
acknowledge the support from US Army Research Laboratory under Contracts
Nos. W911QX-06-C-0124 and W911QX-08-C-0073. Use of the Advanced Photon
Source, an Office of Science User Facility operated for the U.S.
Department of Energy (DOE) Office of Science by Argonne National
Laboratory, was supported by the U.S. DOE under Contract No.
DE-AC02-06CH11357. The authors are grateful for the technical assistance
from Dr. Ren Yang of Argonne National Laboratory in the experiments and
data analysis of SXRD. Authors D.S.D. and M.L.T. gratefully acknowledge
funding from the United States Department of Energy Basic Energy
Sciences (DOE/BES) under the Early Career program through Contract
DE-SC0008274, funding from the Office of Naval Research under Contract
N000141210505, and funding from the Department of Energy's Nuclear
Energy University Program under Contract NE0000315.
NR 44
TC 0
Z9 0
U1 3
U2 3
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1047-4838
EI 1543-1851
J9 JOM-US
JI JOM
PD NOV
PY 2016
VL 68
IS 11
BP 2832
EP 2838
DI 10.1007/s11837-016-2101-0
PG 7
WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical
Engineering; Mineralogy; Mining & Mineral Processing
SC Materials Science; Metallurgy & Metallurgical Engineering; Mineralogy;
Mining & Mineral Processing
GA ED4KG
UT WOS:000388816100019
ER
PT J
AU Ligda, J
D'Antuono, DS
Taheri, ML
Schuster, BE
Wei, Q
AF Ligda, J.
D'Antuono, D. Scotto
Taheri, M. L.
Schuster, B. E.
Wei, Q.
TI Quasi-static Tensile and Compressive Behavior of Nanocrystalline
Tantalum Based on Miniature Specimen Testing-Part II: Mechanical
Properties
SO JOM
LA English
DT Article
ID HIGH-PRESSURE TORSION; ATOMIC BOND PARAMETERS; ULTRAFINE GRAIN SIZES;
SHEAR BANDS; PURE METALS; BCC METALS; TUNGSTEN; MICROSTRUCTURE;
DEFORMATION; FE
AB In Part I of this work (this issue), we presented the microstructure of tantalum processed by high-pressure torsion (HPT). In this part, we will present results based on site-specific micro-mechanical testing. The experimental techniques were used due to the intrinsic microstructure gradient associated with HPT processing. The primary objective is to explore the grain size effect on the quasi-static mechanical properties of HPT processed tantalum with ultrafine grained (UFG, grain size d < 1000 nm and d > 100 nm) and nanocrystalline (NC, d < 100 nm) microstructure. Two distinct deformation modes are observed, i.e. a homogeneous (non-shearing) region and a localized (shear banding) region. Transmission electron microscopy (TEM) and orientation imaging microscopy (OIM) show that the shear bands form by grain rotation. Comparing d in these two regions to the mechanism proposed in the literature shows that reduced d in the shear banding region is more susceptible to localized shearing via grain rotation. This work unifies, or at least further substantiates, the notion that body-centered cubic metals with UFG/NC microstructure tend to have localized shear band even under quasi-static uniaxial compression.
C1 [Ligda, J.] Univ North Carolina Charlotte, PhD Program Nanoscale Sci & Technol, Charlotte, NC 28223 USA.
[Ligda, J.; Schuster, B. E.] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA.
[D'Antuono, D. Scotto; Taheri, M. L.] Drexel Univ, Dept Mat Sci, Philadelphia, PA 19104 USA.
[Wei, Q.] Univ North Carolina Charlotte, Dept Mech Engn, Charlotte, NC 28223 USA.
RP Wei, Q (reprint author), Univ North Carolina Charlotte, Dept Mech Engn, Charlotte, NC 28223 USA.
EM qwei@uncc.edu
RI Wei, Qiuming/B-7579-2008
FU US Army Research Laboratory [W911QX-06-C-0124, W911QX-08-C-0073]; U.S.
DOE [DE-AC02-06CH11357]; United States Department of Energy Basic Energy
Sciences (DOE/BES) under the Early Career program [DE-SC0008274]; Office
of Naval Research [N000141210505]; Department of Energy's Nuclear Energy
University Program [NE0000315]
FX We would like to thank Professor Ruslan Valiev for performing
high-pressure torsion on the Ta disk and Dr. Shailendra Joshi for
discussions on the grain rotation theory. Q. Wei would like to
acknowledge the support from US Army Research Laboratory under Contracts
Nos. W911QX-06-C-0124 and W911QX-08-C-0073. Use of the Advanced Photon
Source, an Office of Science User Facility operated for the U.S.
Department of Energy (DOE) Office of Science by Argonne National
Laboratory, was supported by the U.S. DOE under Contract No.
DE-AC02-06CH11357. The authors are grateful for the technical assistance
from Dr. Ren Yang of Argonne National Laboratory in the experiments and
data analysis of SXRD. Authors D.S.D. and M.L.T. gratefully acknowledge
funding from the United States Department of Energy Basic Energy
Sciences (DOE/BES) under the Early Career program through Contract
DE-SC0008274, funding from the Office of Naval Research under Contract
N000141210505, and funding from the Department of Energy's Nuclear
Energy University Program under Contract NE0000315.
NR 38
TC 0
Z9 0
U1 1
U2 1
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1047-4838
EI 1543-1851
J9 JOM-US
JI JOM
PD NOV
PY 2016
VL 68
IS 11
BP 2839
EP 2846
DI 10.1007/s11837-016-2103-y
PG 8
WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical
Engineering; Mineralogy; Mining & Mineral Processing
SC Materials Science; Metallurgy & Metallurgical Engineering; Mineralogy;
Mining & Mineral Processing
GA ED4KG
UT WOS:000388816100020
ER
PT J
AU Reckley, LK
Song, SA
Chang, ET
Cable, BB
Certal, V
Camacho, M
AF Reckley, L. K.
Song, S. A.
Chang, E. T.
Cable, B. B.
Certal, V.
Camacho, M.
TI Adenoidectomy can improve obstructive sleep apnoea in young children:
systematic review and meta-analysis
SO JOURNAL OF LARYNGOLOGY AND OTOLOGY
LA English
DT Article
DE Adenoidectomy; Sleep Apnea Syndromes; Review; Systematic; Meta-Analysis
ID APNEA/HYPOPNEA SYNDROME; TONSILLECTOMY; OUTCOMES
AB Objective: To systematically search for studies reporting outcomes for adenoidectomy alone as a treatment for paediatric obstructive sleep apnoea and use the data to perform a meta-analysis.
Methods: Nine databases, including PubMed and Medline, were systematically searched through to 1 April 2016. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement was followed.
Results: A total of 1032 articles were screened and 126 full texts were reviewed. Three paediatric studies (47 patients) reported outcomes. Overall, apnoea-hypopnoea index values decreased from 18.1 +/- 16.8 to 3.1 +/- 5.5 events per hour (28 patients). Random-effects modelling demonstrated a mean difference of-14.43 events per hour (I-2 = 23 per cent (low inconsistency)). The apnoea-hypopnoea index standardised mean difference was -1.14 (large magnitude of effect). The largest reduction in apnoea-hypopnoea index was observed in children aged less than 12 months (reduction of 56.6-94.9 per cent). Lowest oxygen saturation values improved from 80.0 +/- 9.5 to 85.5 +/- 6.0 per cent (13 children).
Conclusion: Adenoidectomy alone has improved obstructive sleep apnoea in children, especially in those aged less than 12 months; however, given the low number of studies, isolated adenoidectomy remains an area for additional research.
C1 [Reckley, L. K.; Song, S. A.; Chang, E. T.; Cable, B. B.; Camacho, M.] Tripler Army Med Ctr, Otolaryngol Head & Neck Surg, 1 Jarrett White Rd, Honolulu, HI 96859 USA.
[Certal, V.] Hosp CUF, Sleep Med Ctr, Dept Otorhinolaryngol, Oporto, Portugal.
[Certal, V.] Univ Porto, Ctr Res Hlth Technol & Informat Syst CINTESIS, Rua Campo Alegre 823, P-4100 Oporto, Portugal.
RP Reckley, LK (reprint author), Tripler Army Med Ctr, Otolaryngol Head & Neck Surg, 1 Jarrett White Rd, Honolulu, HI 96859 USA.
EM lauren.k.reckley.mil@mail.mil
RI FMUP, CINTESIS/C-6631-2014
OI FMUP, CINTESIS/0000-0001-7248-2086
NR 24
TC 1
Z9 1
U1 0
U2 0
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0022-2151
EI 1748-5460
J9 J LARYNGOL OTOL
JI J. Laryngol. Otol.
PD NOV
PY 2016
VL 130
IS 11
BP 990
EP 994
DI 10.1017/S0022215116008938
PG 5
WC Otorhinolaryngology
SC Otorhinolaryngology
GA ED4XW
UT WOS:000388856400003
PM 27707424
ER
PT J
AU Leung, LY
Deng-Bryant, Y
Cardiff, K
Winter, M
Tortella, F
Shear, D
AF Leung, Lai Yee
Deng-Bryant, Ying
Cardiff, Katherine
Winter, Megan
Tortella, Frank
Shear, Deborah
TI Neurochemical changes following combined hypoxemia and hemorrhagic shock
in a rat model of penetrating ballistic-like brain injury: A
microdialysis study
SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
LA English
DT Article
DE Cerebral glucose metabolism; hemorrhagic shock; hypoxemia; intracerebral
microdialysis; traumatic brain injury
ID POSITRON-EMISSION-TOMOGRAPHY; TISSUE OXYGEN-TENSION; EXTRACELLULAR
GLUCOSE; CEREBRAL METABOLISM; HYPOXIA-HYPOTENSION; HEAD-INJURY;
ISCHEMIA; LACTATE; TRAUMA; HYPERGLYCOLYSIS
AB BACKGROUND Energy metabolic dysfunction is a key determinant of cellular damage following traumatic brain injury and may be worsened by additional insults. This study evaluated the acute/subacute effects of combined hypoxemia (HX) and hemorrhagic shock (HS) on cerebral interstitial levels of glucose, lactate, and pyruvate in a rat model of penetrating ballistic-like brain injury (PBBI).
METHODS Rats were randomly assigned into the sham control, PBBI, and combined injury (P + HH) groups. The P + HH group received PBBI followed by 30-minute HX and 30 minute HS. Samples were collected from striatum (perilesional region) using intracerebral microdialysis at 1 to 3 hours after injury and then at 1 to 3, 7, and 14 days after injury. Glucose, lactate, and pyruvate were measured in the dialysate samples.
RESULTS Glucose levels dropped significantly up to 24 hours following injury in both PBBI and P + HH groups (p < 0.05). A reduction in pyruvate was observed in the PBBI group from 24 to 72 hours after injury (vs. sham). In the P + HH group, the pyruvate was significantly reduced from 2 to 24 hours after injury (p < 0.05 vs. PBBI). This prominent reduction persisted for 14 days after injury. In contrast, lactate levels were significantly increased in the PBBI group during the first 24 hours after injury and remained elevated out to 7 days. The P + HH group exhibited a similar trend of lactate increase as did the PBBI group. Critically, P + HH further increased the lactate-to-pyruvate ratio by more than twofold (vs. PBBI) during the first 24 hours. The ratio reached a peak at 2 hours and then gradually decreased, but the level remained significantly higher than that in the sham control from 2 to 14 days after injury (p < 0.05).
CONCLUSION This study identified the temporal profile of energy-related neurochemical dysregulation induced by PBBI and combined injury in the perilesional region. Furthermore, combined HX and HS further reduced the pyruvate level and increased the lactate-to-pyruvate ratio following PBBI, indicating the exacerbation of posttraumatic metabolic perturbation.
C1 [Leung, Lai Yee; Deng-Bryant, Ying; Cardiff, Katherine; Winter, Megan; Tortella, Frank; Shear, Deborah] Walter Reed Army Inst Res, Brain Trauma Neuroprotect & Neurorestorat Branch, Ctr Mil Psychiat & Neurosci, Silver Spring, MD USA.
RP Leung, LY (reprint author), 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM laiyee.leung.ctr@mail.mil
FU Combat Casualty Care Research Program
FX This research is funded by the Combat Casualty Care Research Program.
NR 41
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Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 2163-0755
EI 2163-0763
J9 J TRAUMA ACUTE CARE
JI J. Trauma Acute Care Surg.
PD NOV
PY 2016
VL 81
IS 5
BP 860
EP 867
DI 10.1097/TA.0000000000001206
PG 8
WC Critical Care Medicine; Surgery
SC General & Internal Medicine; Surgery
GA EC0IG
UT WOS:000387782800009
PM 27769083
ER
PT J
AU Gaynor, AT
Guest, JK
AF Gaynor, Andrew T.
Guest, James K.
TI Topology optimization considering overhang constraints: Eliminating
sacrificial support material in additive manufacturing through design
SO STRUCTURAL AND MULTIDISCIPLINARY OPTIMIZATION
LA English
DT Article
DE Additive manufacturing; 3D printing; Projection methods; Anchors; Design
for additive manufacturing; Self-supporting; Overhang features
ID MINIMUM LENGTH SCALE; COMPLIANT MECHANISMS; PROJECTION; LAYOUTS;
FILTERS; SCHEME
AB Additively manufactured components often require temporary support material to prevent the component from collapsing or warping during fabrication. Whether these support materials are removed chemically as in the case of many polymer additive manufacturing processes, or mechanically as in the case of (for example) Direct Metal Laser Sintering, the use of sacrificial material increases total material usage, build time, and time required in post-fabrication treatments. The goal of this work is to embed a minimum allowable self-supporting angle within the topology optimization framework such that designed components and structures may be manufactured without the use of support material. This is achieved through a series of projection operations that combine a local projection to enforce minimum length scale requirements and a support region projection to ensure a feature is adequately supported from below. The magnitude of the self-supporting angle is process dependent and is thus an input variable provided by the manufacturing or design engineer. The algorithm is demonstrated on standard minimum compliance topology optimization problems and solutions are shown to satisfy minimum length scale, overhang angle, and volume constraints, and are shown to be dependent on the allowable magnitudes of these constraints.
C1 [Gaynor, Andrew T.] US Army Res Lab, Mat Mfg Technol Branch, Weap & Mat Res Directorate, RDRL WMM D, Bldg 4600, Aberdeen, MD 21005 USA.
[Guest, James K.] Johns Hopkins Univ, Dept Civil Engn, 3400 N Charles St, Baltimore, MD 21218 USA.
RP Gaynor, AT (reprint author), US Army Res Lab, Mat Mfg Technol Branch, Weap & Mat Res Directorate, RDRL WMM D, Bldg 4600, Aberdeen, MD 21005 USA.
EM andrew.t.gaynor2.ctr@mail.mil; jkguest@jhu.edu
FU U.S. Department of Energy; USARL; US National Science Foundation
[1462453]
FX This research was partially supported by an appointment of the first
author to the Postgraduate Research Participation Program at the U.S.
Army Research Laboratory (USARL) administered by the Oak Ridge Institute
for Science and Education through an interagency agreement between the
U.S. Department of Energy and USARL, and partially supported by the US
National Science Foundation under award 1462453. The authors also thank
Krister Svanberg for kindly providing the MMA optimizer code. Any
opinions, findings, and conclusions or recommendations expressed in this
article are those of the authors and do not necessarily reflect the
views of the National Science Foundation, the Department of Energy, or
the Army Research Lab.
NR 40
TC 0
Z9 0
U1 17
U2 17
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1615-147X
EI 1615-1488
J9 STRUCT MULTIDISCIP O
JI Struct. Multidiscip. Optim.
PD NOV
PY 2016
VL 54
IS 5
SI SI
BP 1157
EP 1172
DI 10.1007/s00158-016-1551-x
PG 16
WC Computer Science, Interdisciplinary Applications; Engineering,
Multidisciplinary; Mechanics
SC Computer Science; Engineering; Mechanics
GA EC1FT
UT WOS:000387850900005
ER
PT J
AU Burnouf, T
Dye, JM
Ambe, J
Abayomi, A
AF Burnouf, T.
Dye, J. M.
Ambe, J.
Abayomi, A.
CA Global Emerging Pathogens
TI Convalescent Ebola plasma: assessing neutralizing antibodies at the
right stage
SO VOX SANGUINIS
LA English
DT Letter
C1 [Burnouf, T.] Taipei Med Univ, Grad Inst Biomed Mat & Tissue Engn, Taipei, Taiwan.
[Burnouf, T.] Taipei Med Univ, Coll Biomed Engn, Taipei, Taiwan.
[Dye, J. M.] US Army Med Res Inst Infect Dis, Ft Detrick, MA USA.
[Ambe, J.; Abayomi, A.; Global Emerging Pathogens] Mainland Hosp, GET, 1 Mainland Hosp Rd, Lagos, Nigeria.
[Abayomi, A.] Univ Stellenbosch, Fac Med & Hlth Sci, Cape Town, South Africa.
[Abayomi, A.] Tygerberg Hosp, Natl Hlth Lab Serv, Cape Town, South Africa.
RP Burnouf, T (reprint author), Taipei Med Univ, Coll Biomed Engn, Grad Inst Biomed Mat & Tissue Engn, 250 Wu Shin St, Taipei 11031, Taiwan.
EM thburnouf@gmail.com
NR 5
TC 0
Z9 0
U1 3
U2 3
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0042-9007
EI 1423-0410
J9 VOX SANG
JI Vox Sang.
PD NOV
PY 2016
VL 111
IS 4
BP 456
EP 457
DI 10.1111/vox.12445
PG 2
WC Hematology
SC Hematology
GA EC6XS
UT WOS:000388280600020
PM 27564531
ER
PT J
AU Tian, H
Deng, BC
Chin, ML
Yan, XD
Jiang, H
Han, SJ
Sun, VVA
Xia, QF
Dubey, M
Xia, FN
Wang, H
AF Tian, He
Deng, Bingchen
Chin, Matthew L.
Yan, Xiaodong
Jiang, Hao
Han, Shu-Jen
Sun, Vivian
Xia, Qiangfei
Dubey, Madan
Xia, Fengnian
Wang, Han
TI A Dynamically Reconfigurable Ambipolar Black Phosphorus Memory Device
SO ACS NANO
LA English
DT Article
DE two-dimensional materials; black phosphorus; nonvolatile memory;
reconfigurable; multilevel-cell
ID FIELD-EFFECT TRANSISTORS; NONVOLATILE MEMORY; FLASH MEMORY; LOGIC-GATE;
LAYER MOS2; GRAPHENE; MOBILITY; SEMICONDUCTOR; TRANSPORT; SILICON
AB Nonvolatile charge-trap memory plays an important role in many modern electronics technologies, from portable electronic systems to large-scale data centers. Conventional charge-trap memory devices typically work with fixed channel carrier polarity and device characteristics. However, many emerging applications in reconfigurable electronics and neuromorphic computing require dynamically tunable properties in their electronic device components that can lead to enhanced circuit versatility and system functionalities. Here, we demonstrate an ambipolar black phosphorus (BP) charge-trap memory device with dynamically reconfigurable and polarity reversible memory behavior. This BP memory device shows versatile memory properties subject to electrostatic bias. Not only the programmed/erased state current ratio can be continuously tuned by the back-gate bias, but also the polarity of the carriers in the BP channel can be reversibly switched between electron- and hole-dominated conductions, resulting in the erased and programmed states exhibiting interchangeable high and low current levels. The BP memory also shows four different memory states and, hence, 2-bit per cell data storage for both n-type and p-type channel conductions, demonstrating the multilevel cell storage capability in a layered material based memory device. The BP memory device with a high mobility and tunable programmed/erased state current ratio and highly reconfigurable device characteristics can offer adaptable memory device properties for many emerging applications in electronics technology, such as neuromorphic computing, data-adaptive energy efficient memory, and dynamically reconfigurable digital circuits.
C1 [Tian, He; Yan, Xiaodong; Wang, Han] Univ Southern Calif, Ming Hsieh Dept Elect Engn, 3737 W Way, Los Angeles, CA 90089 USA.
[Deng, Bingchen; Xia, Fengnian] Yale Univ, Dept Elect Engn, 15 Prospect St, New Haven, CT 06511 USA.
[Chin, Matthew L.; Dubey, Madan] US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
[Jiang, Hao; Xia, Qiangfei] Univ Massachusetts, Dept Elect & Comp Engn, 100 Nat Resources Rd, Amherst, MA 01003 USA.
[Han, Shu-Jen] IBM TJ Watson Res Ctr, 1101 Kitchawan Rd, Yorktown Hts, NY 10598 USA.
[Sun, Vivian] Peddie Sch, 201 South Main St, Hightstown, NJ 08520 USA.
RP Wang, H (reprint author), Univ Southern Calif, Ming Hsieh Dept Elect Engn, 3737 W Way, Los Angeles, CA 90089 USA.; Xia, FN (reprint author), Yale Univ, Dept Elect Engn, 15 Prospect St, New Haven, CT 06511 USA.
EM fengnian.xia@yale.edu; han.wang.4@usc.edu
FU Army Research Office [W911NF-16-1-0435]; Northrop Grumman Institute of
Optical Nanomaterials and Nanophotonics (NG-ION2) at USC; Office of
Naval Research through the Young Investigator Program
[N00014-15-1-2733]; Air Force Office of Scientific Research
[FA9550-14-1-0277]; Air Force Office for Scientific Research
[FA9550-12-1-0038]
FX This work is supported by the Army Research Office, Grant No.
W911NF-16-1-0435, and the Northrop Grumman Institute of Optical
Nanomaterials and Nanophotonics (NG-ION2) at USC. F.X.
acknowledges support from the Office of Naval Research through the Young
Investigator Program (Grant No. N00014-15-1-2733) and the Air Force
Office of Scientific Research (Grant No. FA9550-14-1-0277). Q.X. thanks
the Air Force Office for Scientific Research for support (Grant No.
FA9550-12-1-0038).
NR 46
TC 0
Z9 0
U1 37
U2 37
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1936-0851
EI 1936-086X
J9 ACS NANO
JI ACS Nano
PD NOV
PY 2016
VL 10
IS 11
BP 10428
EP 10435
DI 10.1021/acsnano.6b06293
PG 8
WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience &
Nanotechnology; Materials Science, Multidisciplinary
SC Chemistry; Science & Technology - Other Topics; Materials Science
GA ED5SR
UT WOS:000388913100074
PM 27794601
ER
PT J
AU Martino, LE
Dona, CL
Dicerbo, J
Hawkins, A
Moore, B
Horner, R
AF Martino, Louis E.
Dona, Carol L.
Dicerbo, Jerry
Hawkins, Amy
Moore, Beth
Horner, Robert
TI Green and sustainable remediation practices in Federal Agency cleanup
programs
SO ENVIRONMENTAL EARTH SCIENCES
LA English
DT Article
DE Green remediation; Sustainability; Environmental footprint; EO 13693;
Sustainable remediation; Forum (SURF); Green cleanups
AB Federal agencies manage hazardous waste sites under the assumption that environmental restoration will improve the environment by returning contaminated groundwater to beneficial use, removing waste residuals from a site, treating discharges to surface water, and reducing overall risks to human health and the environment. However, the associated time-consuming and expensive operations, extensive performance monitoring, and post-closure care can lead to unanticipated environmental impacts due to both the technological nature of these cleanup activities and the related protracted timelines. These life-cycle impacts can and should be included in the evaluation of remedial alternatives. Increasingly, Federal agencies are considering these life-cycle impacts-variously referred to as "environmental footprint analysis," "sustainable remediation," "green remediation," "greener remediation," and "green and sustainable remediation"when evaluating environmental restoration approaches. For the purposes of this paper, this concept will be referred to as "green and sustainable remediation" (GSR), with application of GSR assumed to take place across the cleanup life cycle, from the investigation phase through site closeout. This paper will discuss the history of GSR, what GSR is, who is implementing GSR, and GSR metrics. The paper will also discuss two approaches to GSR, using case studies to understand and implement it; the first will be a qualitative approach, and the second a more detailed quantitative approach.
C1 [Martino, Louis E.] Argonne Natl Lab, Suite 600,955 LEnfant Plaza SW, Washington, DC 20024 USA.
[Dona, Carol L.] US Army Corps Engineers, Omaha, NE USA.
[Dicerbo, Jerry; Moore, Beth] US DOE, Headquarters, Washington, DC 20585 USA.
[Hawkins, Amy] US Naval Facil Engn Serv Ctr, Port Hueneme, CA USA.
[Horner, Robert] US DOE, ORISE, Washington, DC 20585 USA.
RP Martino, LE (reprint author), Argonne Natl Lab, Suite 600,955 LEnfant Plaza SW, Washington, DC 20024 USA.
EM martinol@anl.gov
FU US Department of Energy [DE-AC02-06CH11357]
FX Argonne National Laboratory's work was supported by the US Department of
Energy under contract DE-AC02-06CH11357.
NR 35
TC 0
Z9 0
U1 1
U2 1
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1866-6280
EI 1866-6299
J9 ENVIRON EARTH SCI
JI Environ. Earth Sci.
PD NOV
PY 2016
VL 75
IS 21
AR 1407
DI 10.1007/s12665-016-6219-8
PG 13
WC Environmental Sciences; Geosciences, Multidisciplinary; Water Resources
SC Environmental Sciences & Ecology; Geology; Water Resources
GA ED1JG
UT WOS:000388600900015
ER
PT J
AU Dean, WK
Caplan, AL
Parent, B
AF Dean, Wendy K.
Caplan, Arthur L.
Parent, Brendan
TI Military Genitourinary Trauma: Policies, Implications, and Ethics
SO HASTINGS CENTER REPORT
LA English
DT Article
C1 [Dean, Wendy K.] US Army Med Res & Mat Command, Ft Detrick, MD 21702 USA.
[Caplan, Arthur L.] NYU, Langone Med Ctr, Div Med Eth, New York, NY 10003 USA.
[Parent, Brendan] NYU, Sch Profess Studies, Appl Hlth, New York, NY 10003 USA.
RP Dean, WK (reprint author), US Army Med Res & Mat Command, Ft Detrick, MD 21702 USA.
OI Parent, Brendan/0000-0003-3057-5684
NR 17
TC 0
Z9 0
U1 1
U2 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0093-0334
EI 1552-146X
J9 HASTINGS CENT REP
JI Hastings Cent. Rep.
PD NOV-DEC
PY 2016
VL 46
IS 6
BP 10
EP 13
DI 10.1002/hast.643
PG 4
WC Ethics; Health Care Sciences & Services; Medical Ethics; Social
Sciences, Biomedical
SC Social Sciences - Other Topics; Health Care Sciences & Services; Medical
Ethics; Biomedical Social Sciences
GA ED1EO
UT WOS:000388587600002
PM 27875650
ER
PT J
AU Weidmann, M
Avsic-Zupanc, T
Bino, S
Bouloy, M
Burt, F
Chinikar, S
Christova, I
Dedushaj, I
El-Sanousi, A
Elaldi, N
Hewson, R
Hufert, FT
Humolli, I
van Vuren, PJ
Tufan, ZK
Korukluoglu, G
Lyssen, P
Mirazimi, A
Neyts, J
Niedrig, M
Ozkul, A
Papa, A
Paweska, J
Sall, AA
Schmaljohn, CS
Swanepoel, R
Uyar, Y
Weber, F
Zeller, H
AF Weidmann, Manfred
Avsic-Zupanc, Tatjana
Bino, Silvia
Bouloy, Michelle
Burt, Felicity
Chinikar, Sadegh
Christova, Iva
Dedushaj, Isuf
El-Sanousi, Ahmed
Elaldi, Nazif
Hewson, Roger
Hufert, Frank T.
Humolli, Isme
van Vuren, Petrus Jansen
Tufan, Zeliha Kocak
Korukluoglu, Gulay
Lyssen, Pieter
Mirazimi, Ali
Neyts, Johan
Niedrig, Matthias
Ozkul, Aykut
Papa, Anna
Paweska, Janusz
Sall, Amadou A.
Schmaljohn, Connie S.
Swanepoel, Robert
Uyar, Yavuz
Weber, Friedemann
Zeller, Herve
TI Biosafety standards for working with Crimean-Congo hemorrhagic fever
virus
SO JOURNAL OF GENERAL VIROLOGY
LA English
DT Review
ID HEALTH-CARE WORKERS; NOSOCOMIAL OUTBREAK; SOUTHERN-AFRICA; VIRAL LOAD;
TRANSMISSION; TURKEY; EPIDEMIOLOGY; INACTIVATION; INFECTION; EBOLA
AB In countries from which Crimean-Congo haemorrhagic fever (CCHF) is absent, the causative virus, CCHF virus (CCHFV), is classified as a hazard group 4 agent and handled in containment level (CL)-4. In contrast, most endemic countries out of necessity have had to perform diagnostic tests under biosafety level (BSL)-2 or -3 conditions. In particular, Turkey and several of the Balkan countries have safely processed more than 100 000 samples over many years in BSL-2 laboratories. It is therefore advocated that biosafety requirements for CCHF diagnostic procedures should be revised, to allow the tests required to be performed under enhanced BSL-2 conditions with appropriate biosafety laboratory equipment and personal protective equipment used according to standardized protocols in the countries affected. Downgrading of CCHFV research work from CL-4, BSL-4 to CL-3, BSL-3 should also be considered.
C1 [Weidmann, Manfred] Univ Stirling, Inst Aquaculture, Stirling, Scotland.
[Avsic-Zupanc, Tatjana] Univ Ljubljana Fac Med, Inst Microbiol & Immunol, Ljubljana, Slovenia.
[Bino, Silvia] Inst Publ Hlth, Control Infect Dis Dept, Tirana, Albania.
[Bouloy, Michelle] Inst Pasteur, Bunyaviruses Mol Genet, Paris, France.
[Burt, Felicity] Univ Free State, Fac Hlth Sci, Dept Med Microbiol & Virol, Bloemfontein, South Africa.
[Chinikar, Sadegh] Pasteur Inst Iran, Natl Ref Lab, Lab Arboviruses & Viral Hemorrhag Fevers, Tehran, Iran.
[Christova, Iva] Natl Ctr Infect & Parasit Dis, Sofia, Bulgaria.
[Dedushaj, Isuf; Humolli, Isme] Natl Inst Publ Hlth Kosovo, Pristina, Kosovo.
[El-Sanousi, Ahmed] Cairo Univ, Fac Vet Med, Dept Virol, Giza, Egypt.
[Elaldi, Nazif] Cumhuriyet Univ, Fac Med, Dept Infect Dis & Clin Microbiol, Sivas, Turkey.
[Hewson, Roger] Publ Hlth England, Salisbury, Wilts, England.
[Hufert, Frank T.] Brandenburg Med Sch, Inst Microbiol & Virol, Senftenberg, Germany.
[van Vuren, Petrus Jansen; Paweska, Janusz] Natl Inst Communicable Dis, Johannesburg, South Africa.
[Tufan, Zeliha Kocak] Yildirim Beyazit Univ, Ankara Ataturk Training & Res Hosp, Infect Dis & Clin Microbiol Dept, Ankara, Turkey.
[Korukluoglu, Gulay] Publ Hlth Inst Turkey, Virol Reference & Res Lab, Ankara, Turkey.
[Lyssen, Pieter; Neyts, Johan] Katholieke Univ Leuven, Rega Inst Med Res, Leuven, Belgium.
[Mirazimi, Ali] Karolinska Inst, Dept Clin Microbiol, Inst Lab Med, Stockholm, Sweden.
[Mirazimi, Ali] Karolinska Hosp Univ, Stockholm, Sweden.
[Niedrig, Matthias] Robert Koch Inst, Highly Pathogen Viruses, Ctr Biol Threats & Special Pathogens, Berlin, Germany.
[Ozkul, Aykut] Ankara Univ, Fac Vet Med, Dept Virol, Ankara, Turkey.
[Papa, Anna] Aristotle Univ Thessaloniki, Sch Med, Dept Microbiol, Thessaloniki, Greece.
[Sall, Amadou A.] Inst Pasteur, Arbovirus unit, Dakar, Senegal.
[Schmaljohn, Connie S.] US Army Med Res Inst Infect Dis, Ft Detrick, MD USA.
[Swanepoel, Robert] Univ Pretoria, Dept Vet Trop Dis, Pretoria, South Africa.
[Uyar, Yavuz] Istanbul Univ, Cerrahpasa Fac Med, Dept Med Microbiol, Istanbul, Turkey.
[Weber, Friedemann] Justus Liebig Univ Giessen, Inst Virol, Giessen, Germany.
[Zeller, Herve] European Ctr Dis Prevent & Control, Stockholm, Sweden.
RP Weidmann, M (reprint author), Univ Stirling, Inst Aquaculture, Stirling, Scotland.
EM m.w.weidmann@stir.ac.uk
RI Weidmann, Manfred/G-1817-2015
OI Weidmann, Manfred/0000-0002-7063-7491
FU European Commission under Health Cooperation Work Program of 7th
Framework Program [260427]
FX Funding was received through CCH Fever Network (Collaborative Project)
supported by the European Commission under the Health Cooperation Work
Program of the 7th Framework Program (grant agreement no. 260427)
(http://www.cch-fever.eu/). The views expressed by state-employed
American co-authors are their personal views, and do not necessarily
represent the views of the US government agencies they work for. The
views expressed by the ECDC coauthor are his personal views, and do not
necessarily represent the views of the European agency he is working
for.
NR 82
TC 1
Z9 1
U1 9
U2 9
PU MICROBIOLOGY SOC
PI LONDON
PA CHARLES DARWIN HOUSE, 12 ROGER ST, LONDON WC1N 2JU, ERKS, ENGLAND
SN 0022-1317
EI 1465-2099
J9 J GEN VIROL
JI J. Gen. Virol.
PD NOV
PY 2016
VL 97
BP 2799
EP 2808
DI 10.1099/jgv.0.000610
PN 11
PG 10
WC Biotechnology & Applied Microbiology; Virology
SC Biotechnology & Applied Microbiology; Virology
GA ED2LV
UT WOS:000388677600001
PM 27667586
ER
PT J
AU Brager, AJ
Yang, T
Ehlen, JC
Simon, RP
Meller, R
Paul, KN
AF Brager, Allison J.
Yang, Tao
Ehlen, J. Christopher
Simon, Roger P.
Meller, Robert
Paul, Ketema N.
TI Sleep Is Critical for Remote Preconditioning-Induced Neuroprotection
SO SLEEP
LA English
DT Article
DE mouse; ischemia; homeostatic; circadian; neuroprotection; tolerance
ID CIRCADIAN CLOCK; ISCHEMIA; STROKE; BRAIN; DEPRIVATION; RATS
AB Study Objectives: Episodes of brief limb ischemia (remote preconditioning) in mice induce tolerance to modeled ischemic stroke (focal brain ischemia). Since stroke outcomes are in part dependent on sleep-wake history, we sought to determine if sleep is critical for the neuroprotective effect of limb ischemia.
Methods: EEG/EMG recording electrodes were implanted in mice. After a 24 h baseline recording, limb ischemia was induced by tightening an elastic band around the left quadriceps for 10 minutes followed by 10 minutes of release for two cycles. Two days following remote preconditioning, a second 24 h EEG/EMG recording was completed and was immediately followed by a 60-minute suture occlusion of the middle cerebral artery (modeled ischemic stroke). This experiment was then repeated in a model of circadian and sleep abnormalities (Bmal1 knockout [KO] mice sleep 2 h more than wild-type littermates). Brain infarction was determined by vital dye staining, and sleep was assessed by trained identification of EEG/EMG recordings.
Results: Two days after limb ischemia, wild-type mice slept an additional 2.4 h. This additional sleep was primarily comprised of non-rapid eye movement (NREM) sleep during the middle of the light-phase (i.e., naps). Repeating the experiment but preventing increases in sleep after limb ischemia abolished tolerance to ischemic stroke. In Bmal1 knockout mice, remote preconditioning did not increase daily sleep nor provide tolerance to subsequent focal ischemia.
Conclusions: These results suggest that sleep induced by remote preconditioning is both sufficient and necessary for its neuroprotective effects on stroke outcome.
C1 [Brager, Allison J.; Ehlen, J. Christopher; Paul, Ketema N.] Morehouse Sch Med, Dept Neurobiol, Circadian Rhythms & Sleep Disorders Program, Atlanta, GA 30310 USA.
[Yang, Tao; Simon, Roger P.; Meller, Robert] Morehouse Sch Med, Inst Neurosci, Translat Programs Stroke, Atlanta, GA 30310 USA.
[Brager, Allison J.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Behav Biol Branch, Silver Spring, MD USA.
[Paul, Ketema N.] Univ Calif Los Angeles, Dept Integrat Biol & Physiol, Los Angeles, CA USA.
RP Brager, AJ; Paul, KN (reprint author), Morehouse Sch Med, Dept Neurobiol, Circadian Rhythms & Sleep Disorders Program, Atlanta, GA 30310 USA.; Brager, AJ (reprint author), Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Behav Biol Branch, Silver Spring, MD USA.; Paul, KN (reprint author), Univ Calif Los Angeles, Dept Integrat Biol & Physiol, Los Angeles, CA USA.
EM allison.brager@gmail.com; ketema.paul@ucla.edu
FU [F32HL116077]; [R01NS078410]; [U54NS060659]; [G12MD007602];
[P50HL117929]; [R01NS59588]
FX This was not an industry supported study. Federal financial support was
provided by: F32HL116077 to Dr. Brager, R01NS078410 to Dr. Paul,
U54NS060659 to Dr. Paul, G12MD007602 to Dr. Meller and Dr. Paul,
P50HL117929 to Dr. Paul, and R01NS59588 to Dr. Meller. The authors have
indicated no financial conflicts of interest. The work was performed at
Morehouse School of Medicine, Atlanta, GA.
NR 21
TC 0
Z9 0
U1 5
U2 5
PU AMER ACAD SLEEP MEDICINE
PI WESTCHESTER
PA ONE WESTBROOK CORPORATE CTR, STE 920, WESTCHESTER, IL 60154 USA
SN 0161-8105
EI 1550-9109
J9 SLEEP
JI Sleep
PD NOV 1
PY 2016
VL 39
IS 11
BP 2033
EP 2040
AR PII sp-00070-16
DI 10.5665/sleep.6238
PG 8
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA ED5YT
UT WOS:000388930800014
PM 27568798
ER
PT J
AU Cole, MA
Scott, TF
Mello, CM
AF Cole, Megan A.
Scott, Timothy F.
Mello, Charlene M.
TI Bactericidal Hydrogels via Surface Functionalization with Cecropin A
SO ACS BIOMATERIALS SCIENCE & ENGINEERING
LA English
DT Article
DE antimicrobial peptide; cecropin A; hydrogel; immobilization; E. coli
ID IMMOBILIZED ANTIMICROBIAL PEPTIDES; MOLECULAR-SIZE DISTRIBUTION;
POLY(ETHYLENE GLYCOL); CIRCULAR-DICHROISM; ESCHERICHIA-COLI; CLICK
CHEMISTRY; RICH PEPTIDE; ANTIBACTERIAL; ANTIBIOTICS; MECHANISM
AB The immobilization of antimicrobial peptides (AMPs) to surfaces, enabling their utilization in biosensor and antibacterial/antifouling coating applications, is typically performed using rigid, solid support materials such as glass or gold and may require lengthy, temperamental protocols. Here, we employ a hydrogel immobilization platform to afford facile fabrication and surface functionalization while offering improved biocompatibility for evaluating the influence of linker length, surface density, and AMP conjugation site on retained peptide activity. Rapid, interfacial photo-polymerization using the radical-mediated thiol-ene addition mechanism was used to generate cross-linked, polymeric coatings bearing residual thiol moieties on prefabricated poly(ethylene glycol) (PEG)-based hydrogel supports. The photo-polymerized coatings were 60 mu m thick and contained 0.55 nmol of unreacted free thiols, corresponding to a concentration of 410 mu M, for use as cecropin A (CPA) immobilization handles via thiol-maleimide conjugation, where the CPA-bound maleimide moiety was localized at either the carboxyl terminus or midsequence between Ala(22) and Gly(23). Surface presentation of the thiol handles was controlled by varying the thiolated PEG monomer (PEGSH) used in the photo-polymerizable formulation. Bactericidal activity of CPA functionalized hydrogels against E. coli K235 indicated that CPA immobilized at the carboxyl terminus killed 94 +/- 6% of the inoculated pathogens when coatings were prepared with high molecular weight PEGSH and 99 +/- 1% when prepared with low molecular weight PEGSH. E. coli cell death demonstrated a stronger dependence on peptide concentration than PEG linker length or degree of thiol functionalization, with activity ranging from 34 +/- 13% to 99 +/- 1% bacterial cells killed as the prefunctionalization thiol concentration in the coatings was increased from 90 to 990 mu M. Finally, the immobilization site on the surface-bound CPA strongly affected antibacterial activity; when midsequence modified CPA was bound to a hydrogel coating bearing 990 mu M thiol, only 20 +/- 4% of the E. coli population was killed.
C1 [Cole, Megan A.; Mello, Charlene M.] US Army, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA.
[Scott, Timothy F.] Univ Michigan, Dept Chem Engn, Ann Arbor, MI 48109 USA.
[Scott, Timothy F.] Univ Michigan, Macromol Sci & Engn Program, Ann Arbor, MI 48109 USA.
RP Mello, CM (reprint author), US Army, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA.; Scott, TF (reprint author), Univ Michigan, Dept Chem Engn, Ann Arbor, MI 48109 USA.; Scott, TF (reprint author), Univ Michigan, Macromol Sci & Engn Program, Ann Arbor, MI 48109 USA.
EM tfscott@umich.edu; charlene.m.mello2.civ@mail.mil
FU Defense Threat Reduction Agency
FX This work has been supported by funding from the Defense Threat
Reduction Agency and was performed while M.A.C. held an NRC Research
Associateship award at the US Army Natick Soldier Research, Development
and Engineering Center (NSRDEC). This manuscript has been approved for
unlimited distribution by the US Army NSRDEC (PAO: U16-430). The authors
would also like to thank the Department of Chemistry and Biochemistry at
the University of Massachusetts, Dart-mouth, for the use of their
facilities; Prof. Zhan Chen at the Department of Chemistry, University
of Michigan, for the use of his CD spectrometer, and J. Jasensky for his
assistance with the CD experiments.
NR 55
TC 0
Z9 0
U1 19
U2 19
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 2373-9878
J9 ACS BIOMATER SCI ENG
JI ACS Biomater. Sci. Eng.
PD NOV
PY 2016
VL 2
IS 11
BP 1894
EP 1904
DI 10.1021/acsbiomaterials.6b00266
PG 11
WC Materials Science, Biomaterials
SC Materials Science
GA EC5GK
UT WOS:000388161200008
ER
PT J
AU Spengler, JR
Estrada-Pena, A
Garrison, AR
Schmaljohn, C
Spiropoulou, CF
Bergeron, E
Bente, DA
AF Spengler, Jessica R.
Estrada-Pena, Agustin
Garrison, Aura R.
Schmaljohn, Connie
Spiropoulou, Christina F.
Bergeron, Eric
Bente, Dennis A.
TI A chronological review of experimental infection studies of the role of
wild animals and livestock in the maintenance and transmission of
Crimean-Congo hemorrhagic fever virus
SO ANTIVIRAL RESEARCH
LA English
DT Review
DE Crimean-Congo hemorrhagic fever; Bunyavirus; Tick-borne; Viral
hemorrhagic fever; Transmission
ID BORNE ENCEPHALITIS-VIRUS; HYALOMMA-TRUNCATUM TICKS; FAMILY BUNYAVIRIDAE;
ANTIBODY-RESPONSE; RISK-FACTORS; HOST; DISEASES; AFRICAN; BIRDS;
EPIDEMIOLOGY
AB This article provides a definitive review of experimental studies of the role of wild animals and livestock in the maintenance and transmission of Crimean-Congo hemorrhagic fever virus (CCHFV), the etiologic agent of Crimean-Congo hemorrhagic fever (CCHF), beginning with the first recognized outbreak of the human disease in Crimea in 1944. Published reports by researchers in the former Soviet Union, Bulgaria, South Africa, and other countries where CCHF has been observed show that CCHFV is maintained in nature in a tick-vertebrate-tick enzootic cycle. Human disease most commonly results from the bite of an infected tick, but may also follow crushing of infected ticks or exposure to the blood and tissues of infected animals during slaughter. Wild and domestic animals are susceptible to infection with CCHFV, but do not develop clinical illness. Vertebrates are important in CCHF epidemiology, as they provide blood meals to support tick populations, transport ticks across wide geographic areas, and transmit CCHFV to ticks and humans during the period of viremia. Many aspects of vertebrate involvement in the maintenance and spread of CCHFV are still poorly understood. Experimental investigations in wild animals and livestock provide important data to aid our understanding of CCHFV ecology. This article is the second in a series of reviews of more than 70 years of research on CCHF, summarizing important findings, identifying gaps in knowledge, and suggesting directions for future research. (C) 2016 Elsevier B.V. All rights reserved.
C1 [Spengler, Jessica R.; Spiropoulou, Christina F.; Bergeron, Eric] Ctr Dis Control & Prevent, Viral Special Pathogens Branch, Div High Consequence Pathogens & Pathol, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA USA.
[Estrada-Pena, Agustin] Univ Zaragoza, Dept Anim Pathol, Zaragoza, Spain.
[Garrison, Aura R.; Schmaljohn, Connie] US Army, Med Res Inst Infect Dis, Frederick, MD USA.
[Bente, Dennis A.] Dept Microbiol & Immunol, Galveston, TX USA.
[Bente, Dennis A.] Univ Texas Med Branch, Galveston Natl Lab, Galveston, TX 77555 USA.
RP Spengler, JR (reprint author), 1600 Clifton Rd,MS G-14, Atlanta, GA 30333 USA.
EM JSpengler@cdc.gov
OI Spengler, Jessica R./0000-0002-5383-0513; Bergeron,
Eric/0000-0003-3398-8628
FU Oak Ridge Institute for Science and Education; National Institutes of
Health Loan Repayment Award; National Institutes of Health
[R01AI109008]; Canadian Institute of Health
FX This work was supported in part by an appointment to the Research
Participation Program at CDC by the Oak Ridge Institute for Science and
Education through an interagency agreement between the US Department of
Energy and CDC (to J.R.S.); by the National Institutes of Health Loan
Repayment Award (to J.R.S.); by the National Institutes of Health grant
R01AI109008 (to E.B.); and by the Canadian Institute of Health (to
E.B.).
NR 111
TC 1
Z9 1
U1 4
U2 4
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0166-3542
EI 1872-9096
J9 ANTIVIR RES
JI Antiviral Res.
PD NOV
PY 2016
VL 135
BP 31
EP 47
DI 10.1016/j.antivira1.2016.09.013
PG 17
WC Pharmacology & Pharmacy; Virology
SC Pharmacology & Pharmacy; Virology
GA ED0QV
UT WOS:000388547900004
PM 27713073
ER
PT J
AU Welder, MD
Warhurst, KA
Anderson, WJL
Salazar, FD
Kertes, SS
Baxter, AC
Stoddard, DR
AF Welder, Matthew D.
Warhurst, Keith A.
Anderson, Wesley J. L.
Salazar, Frank D.
Kertes, Steven S.
Baxter, Andrew C.
Stoddard, Douglas R.
TI Service Block Time Allocation in the US Army Medical Command
SO AORN JOURNAL
LA English
DT Article
DE surgical scheduling; service block time; utilization; backlog; OR
schedule
ID MULTIPLE OBJECTIVES; EFFICIENCY; MANAGEMENT
AB Service block time allocation is a critical requirement for the optimization of patient throughput and access to care in the Surgical Services Service Line of the US Army Medical Command. The procedure complexity, volume, and diversity across 25 facilities create significant variation in service block time. This variation requires the involvement of both the informatics and leadership teams for block time allocation to be effective. This article describes our use of the Army's Surgery Scheduling System, which includes service block time as an embedded function, to develop a standardized process that helps ensure service block time is optimized. We also present guidelines for block time allocation and offer case studies that demonstrate the application of these guidelines. (C) AORN, Inc, 2016.
C1 [Welder, Matthew D.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
[Welder, Matthew D.; Warhurst, Keith A.] US Army Med Command, Off Surgeon Gen, Surg Serv Serv Line, Falls Church, VA USA.
[Anderson, Wesley J. L.] Kirk US Army Hlth Clin, Aberdeen Proving Ground, MD USA.
[Salazar, Frank D.] Army Med Command Headquarters, San Antonio, TX USA.
[Kertes, Steven S.] US Army Human Resources Command, Ft Knox, KY USA.
[Baxter, Andrew C.] US Army Garrison, Combat Support Hosp 121, Surg Serv, Seoul, South Korea.
[Baxter, Andrew C.] US Army Garrison, Brian Allgood Army Community Hosp, Seoul, South Korea.
[Stoddard, Douglas R.] Madigan Army Med Ctr, Tacoma, WA 98431 USA.
RP Welder, MD (reprint author), Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
NR 22
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0001-2092
J9 AORN J
JI AORN J.
PD NOV
PY 2016
VL 104
IS 5
BP 417
EP 425
DI 10.1016/j.aorn.2016.09.003
PG 9
WC Nursing
SC Nursing
GA EC9VU
UT WOS:000388493200010
PM 27793252
ER
PT J
AU Liu, RF
Yu, XP
Wallqvist, A
AF Liu, Ruifeng
Yu, Xueping
Wallqvist, Anders
TI Using Chemical-Induced Gene Expression in Cultured Human Cells to
Predict Chemical Toxicity
SO CHEMICAL RESEARCH IN TOXICOLOGY
LA English
DT Article
ID SCALE TOXICOGENOMICS DATABASE; ACUTE INTERSTITIAL NEPHRITIS;
TORSADES-DE-POINTES; QT PROLONGATION; DRUG DISCOVERY; HISTOPATHOLOGY;
CHOLESTASIS; STEROIDS; DANAZOL; LIVER
AB Chemical toxicity is conventionally evaluated in animal models. However, animal models are resource intensive; moreover, they face ethical and scientific challenges because the outcomes obtained "by animal testing may not correlate with human responses. To develop an alternative method for assessing chemical toxicity, we investigated the feasibility of using chemical-induced genome-wide expression changes in cultured human cells to predict the potential of a chemical to cause specific organ injuries in humans. We first created signatures of chemical-induced "gene expression in a vertebral-cancer of the prostate cell line for 45,000 chemicals tested in the US National Institutes of Health Library of Integrated Network-Based Cellular Signatures program. We then used the signatures to create naive Bayesian prediction models for chemical-induced human liver cholestasis, interstitial nephritis, and long QT syndrome. Detailed cross-validation analyses indicated that the models were robust with respect to false positives and false negatives in the samples we used to train the models and could predict the likelihood that chemicals would cause specific organ injuries. In addition, we performed a literature search for drugs and dietary supplements, not formally categorized as causing organ injuries in humans but predicted by our models to be most likely to do so. We found a high percentage of these compounds associated with case reports of relevant organ injuries, lending support to the idea that in vitro cell-based experiments can be used to predict the toxic potential of chemicals. We believe that this approach, combined with a robust technique to model human exposure to chemicals, may serve as a promising alternative to animal-based chemical toxicity assessment.
C1 [Liu, Ruifeng; Yu, Xueping; Wallqvist, Anders] US Army Med Res & Mat Command, Dept Def, Biotechnol High Performance Comp Software Applica, Telemed & Adv Technol Res Ctr, Ft Detrick, MD 21702 USA.
RP Liu, RF; Wallqvist, A (reprint author), US Army Med Res & Mat Command, Dept Def, Biotechnol High Performance Comp Software Applica, Telemed & Adv Technol Res Ctr, Ft Detrick, MD 21702 USA.
EM rliu@bhsai.org; sven.a.wallqvist.civ@mail.mil
FU US Army Medical Research and Materiel Command (Ft. Detrick, MD) as part
of the US Army's Network Science Initiative; Defense Threat Reduction
Agency [CBCall14-CBS-05-2-0007]
FX The research was supported by the US Army Medical Research and Materiel
Command (Ft. Detrick, MD) as part of the US Army's Network Science
Initiative, and by the Defense Threat Reduction Agency (Grant No.
CBCall14-CBS-05-2-0007).
NR 51
TC 0
Z9 0
U1 2
U2 2
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0893-228X
EI 1520-5010
J9 CHEM RES TOXICOL
JI Chem. Res. Toxicol.
PD NOV
PY 2016
VL 29
IS 11
BP 1883
EP 1893
DI 10.1021/acs.chemrestox.6b00287
PG 11
WC Chemistry, Medicinal; Chemistry, Multidisciplinary; Toxicology
SC Pharmacology & Pharmacy; Chemistry; Toxicology
GA ED0QY
UT WOS:000388548200013
PM 27768846
ER
PT J
AU Amour, C
Gratz, J
Mduma, E
Svensen, E
Rogawski, ET
McGrath, M
Seidman, JC
McCormick, BJJ
Shrestha, S
Samie, A
Mahfuz, M
Qureshi, S
Hotwani, A
Babji, S
Trigoso, DR
Lima, AAM
Bodhidatta, L
Bessong, P
Ahmed, T
Shakoor, S
Kang, G
Kosek, M
Guerrant, RL
Lang, D
Gottlieb, M
Houpt, ER
Platts-Mills, JA
AF Amour, Caroline
Gratz, Jean
Mduma, Estomih
Svensen, Erling
Rogawski, Elizabeth T.
McGrath, Monica
Seidman, Jessica C.
McCormick, Benjamin J. J.
Shrestha, Sanjaya
Samie, Amidou
Mahfuz, Mustafa
Qureshi, Shahida
Hotwani, Aneeta
Babji, Sudhir
Trigoso, Dixner Rengifo
Lima, Aldo A. M.
Bodhidatta, Ladaporn
Bessong, Pascal
Ahmed, Tahmeed
Shakoor, Sadia
Kang, Gagandeep
Kosek, Margaret
Guerrant, Richard L.
Lang, Dennis
Gottlieb, Michael
Houpt, Eric R.
Platts-Mills, James A.
CA Etiology Risk Factors Interactions
TI Epidemiology and Impact of Campylobacter Infection in Children in 8
Low-Resource Settings: Results From the MAL-ED Study
SO CLINICAL INFECTIOUS DISEASES
LA English
DT Article
DE Campylobacter; children; risk factors; growth; inflammation
ID RANDOMIZED CONTROLLED-TRIAL; DEVELOPING-COUNTRIES; LINEAR GROWTH; MASS
AZITHROMYCIN; EGYPTIAN CHILDREN; PERUVIAN CHILDREN; TRACHOMA CONTROL;
BIRTH COHORT; ADULT HEALTH; RISK-FACTORS
AB Background. Enteropathogen infections have been associated with enteric dysfunction and impaired growth in children in low-resource settings. In a multisite birth cohort study (MAL-ED), we describe the epidemiology and impact of Campylobacter infection in the first 2 years of life.
Methods. Children were actively followed up until 24 months of age. Diarrheal and nondiarrheal stool samples were collected and tested by enzyme immunoassay for Campylobacter. Stool and blood samples were assayed for markers of intestinal permeability and inflammation.
Results. A total of 1892 children had 7601 diarrheal and 26 267 nondiarrheal stool samples tested for Campylobacter. We describe a high prevalence of infection, with most children (n = 1606; 84.9%) having a Campylobacter-positive stool sample by 1 year of age. Factors associated with a reduced risk of Campylobacter detection included exclusive breastfeeding (risk ratio, 0.57; 95% confidence interval, .47-.67), treatment of drinking water (0.76; 0.70-0.83), access to an improved latrine (0.89; 0.82-0.97), and recent macrolide antibiotic use (0.68; 0.63-0.74). A high Campylobacter burden was associated with a lower length-for-age Z score at 24 months (-1.82; 95% confidence interval, -1.94 to -1.70) compared with a low burden (-1.49; -1.60 to -1.38). This association was robust to confounders and consistent across sites. Campylobacter infection was also associated with increased intestinal permeability and intestinal and systemic inflammation.
Conclusions. Campylobacter was prevalent across diverse settings and associated with growth shortfalls. Promotion of exclusive breastfeeding, drinking water treatment, improved latrines, and targeted antibiotic treatment may reduce the burden of Campylobacter infection and improve growth in children in these settings.
C1 [Amour, Caroline; Gratz, Jean; Mduma, Estomih] Haydom Lutheran Hosp, Haydom, Tanzania.
[Gratz, Jean; Rogawski, Elizabeth T.; Guerrant, Richard L.; Houpt, Eric R.; Platts-Mills, James A.] Univ Virginia, Div Infect Dis & Int Hlth, POB 801340, Charlottesville, VA 22908 USA.
[McGrath, Monica; Seidman, Jessica C.; McCormick, Benjamin J. J.] NIH, Fogarty Int Ctr, Bldg 10, Bethesda, MD 20892 USA.
[Lang, Dennis; Gottlieb, Michael] Fdn Natl Inst Hlth, Bethesda, MD USA.
[Kosek, Margaret] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Baltimore, MD USA.
[Svensen, Erling] Haukeland Hosp, Bergen, Norway.
[Shrestha, Sanjaya; Bodhidatta, Ladaporn] Armed Forces Res Inst Med Sci, Bangkok, Thailand.
[Samie, Amidou; Bessong, Pascal] Univ Venda, Thohoyandou, South Africa.
[Mahfuz, Mustafa; Ahmed, Tahmeed] Int Ctr Diarrhoeal Dis Res, Dhaka, Bangladesh.
[Qureshi, Shahida; Hotwani, Aneeta; Shakoor, Sadia] Aga Khan Univ, Karachi, Pakistan.
[Babji, Sudhir; Kang, Gagandeep] Christian Med Coll & Hosp, Vellore, Tamil Nadu, India.
[Trigoso, Dixner Rengifo; Kosek, Margaret] Asociac Benef PRISMA, Iquitos, Peru.
[Lima, Aldo A. M.] Univ Fed Ceara, Clin Res Unit, Fortaleza, Ceara, Brazil.
[Lima, Aldo A. M.] Univ Fed Ceara, Inst Biomed, Fortaleza, Ceara, Brazil.
RP Platts-Mills, JA (reprint author), Univ Virginia, Div Infect Dis & Int Hlth, POB 801340, Charlottesville, VA 22908 USA.
EM jp5t@virginia.edu
RI Strand, Tor/D-9836-2016
OI Strand, Tor/0000-0002-4038-151X
FU Bill & Melinda Gates Foundation; Foundation for the National Institutes
of Health; National Institutes of Health, Fogarty International Center;
National Institutes of Health [5K23-AI114888-02]
FX The Etiology, Risk Factors, and Interactions of Enteric Infections and
Malnutrition and the Consequences for Child Health and Development
Project (MAL-ED) is carried out as a collaborative project supported by
the Bill & Melinda Gates Foundation, the Foundation for the National
Institutes of Health, and the National Institutes of Health, Fogarty
International Center. J. A. P. receives support from the National
Institutes of Health (5K23-AI114888-02).
NR 46
TC 1
Z9 1
U1 4
U2 4
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1058-4838
EI 1537-6591
J9 CLIN INFECT DIS
JI Clin. Infect. Dis.
PD NOV 1
PY 2016
VL 63
IS 9
BP 1171
EP 1179
DI 10.1093/cid/ciw542
PG 9
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA EC2WY
UT WOS:000387986200009
PM 27501842
ER
PT J
AU Labukas, J
AF Labukas, Joe
TI Department of Defense-Allied Nations Special Issue
SO CORROSION
LA English
DT Editorial Material
C1 [Labukas, Joe] US Army Res Lab, Corros & Surface Sci Team, Adelphi, MD 20783 USA.
RP Labukas, J (reprint author), US Army Res Lab, Corros & Surface Sci Team, Adelphi, MD 20783 USA.
NR 0
TC 0
Z9 0
U1 3
U2 3
PU NATL ASSOC CORROSION ENG
PI HOUSTON
PA 1440 SOUTH CREEK DRIVE, HOUSTON, TX 77084-4906 USA
SN 0010-9312
EI 1938-159X
J9 CORROSION-US
JI Corrosion
PD NOV
PY 2016
VL 72
IS 11
BP 1327
EP 1327
PG 1
WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical
Engineering
SC Materials Science; Metallurgy & Metallurgical Engineering
GA EC8DJ
UT WOS:000388370200001
ER
PT J
AU Ruiz, SI
El-Gendy, N
Bowen, LE
Berkland, C
Bailey, MM
AF Ruiz, Sara I.
El-Gendy, Nashwa
Bowen, Larry E.
Berkland, Cory
Bailey, Mark M.
TI Formulation and Characterization of Nanocluster Ceftazidime for the
Treatment of Acute Pulmonary Melioidosis
SO JOURNAL OF PHARMACEUTICAL SCIENCES
LA English
DT Article
DE NanoCluster; ceftazidime; pulmonary melioidosis; aerosols; dry powder
ID DRY POWDER AEROSOLS; CONTRAST AGENT; PROPHYLAXIS; DELIVERY; MODEL; ACID
AB Melioidosis is an infectious disease caused by Burkholderia pseudomallei. The disease is responsible for a high proportion of human pneumonia and fatal bacteremia in the endemic areas of the world and is highly resistant to most commonly available antibiotics. Studies have shown that prophylactic antibiotic treatment, when administered 24 h following bacterial challenge, can prevent infection in a murine model. Prophylactic treatment against this disease using a pulmonary antibiotic formulation has not previously been examined, but may reduce the number of treatments required, allow for the delivery of higher doses, eliminate the need for intravenous administration, and help to minimize systemic side effects. Ceftazidime was formulated as a dry powder aerosol suitable for pulmonary delivery using previously developed NanoCluster dry powder technology. Pharmacokinetics of aerosolized ceftazidime was analyzed in a mouse model. This study demonstrates that ceftazidime can be formulated using NanoCluster technology as a dry powder aerosol suitable for pulmonary delivery to humans. We have also demonstrated the retention of nebulized ceftazidime in mouse lungs for up to 6 h after exposure. The results indicate that this treatment may be useful as a prophylactic treatment against melioidosis. Future work will examine the efficacy of this treatment against B. pseudomallei aerosol challenge. Published by Elsevier Inc. on behalf of the American Pharmacists Association.
C1 [Ruiz, Sara I.; Bowen, Larry E.; Bailey, Mark M.] US Army Med Res Inst Infect Dis, Aerobiol, Ft Detrick, MD 21702 USA.
[Ruiz, Sara I.; Bowen, Larry E.] Keaki Technol, Aerobiol, Frederick, MD 21704 USA.
[El-Gendy, Nashwa; Berkland, Cory] Univ Kansas, Dept Pharmaceut Chem, Lawrence, KS 66047 USA.
[Bowen, Larry E.] Clin Res Management, Aerobiol, Frederick, MD 21701 USA.
[Berkland, Cory] Univ Kansas, Dept Chem & Petr Engn, Lawrence, KS 66045 USA.
RP Bailey, MM (reprint author), US Army Med Res Inst Infect Dis, Aerobiol, Ft Detrick, MD 21702 USA.
EM mark.m.bailey2.mil@mail.mil
FU Defense Threat Reduction Agency (DTRA)
FX The authors gratefully acknowledge funding from the Defense Threat
Reduction Agency (DTRA). The authors also acknowledge David Dyer,
Samantha Baker, Jeanean Ghering, and Chris Jensen for laboratory
technical support. The authors would like to acknowledge CellMosaic,
Inc. for HPLC support. Authors Nashwa El-Gendy, Cory Berkland, and Mark
M. Bailey are coinventors on the patented NanoCluster
technology.32
NR 31
TC 0
Z9 0
U1 2
U2 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-3549
EI 1520-6017
J9 J PHARM SCI-US
JI J. Pharm. Sci.
PD NOV
PY 2016
VL 105
IS 11
BP 3399
EP 3408
DI 10.1016/j.xphs.2016.07.029
PG 10
WC Chemistry, Medicinal; Chemistry, Multidisciplinary; Pharmacology &
Pharmacy
SC Pharmacology & Pharmacy; Chemistry
GA EC6SY
UT WOS:000388268200019
PM 27639659
ER
PT J
AU Jones, A
AF Jones, Alvin
TI Cutoff Scores for MMPI-2 and MMPI-2-RF Cognitive-Somatic Validity Scales
for Psychometrically Defined Malingering Groups in a Military Sample
SO ARCHIVES OF CLINICAL NEUROPSYCHOLOGY
LA English
DT Article
DE MMPI-2; MMPI-2-R; Malingering; Military; Symptom validity
ID RESPONSE BIAS SCALE; TRAUMATIC BRAIN-INJURY; HENRY-HEILBRONNER INDEX;
FAKE BAD SCALE; SYMPTOM VALIDITY; CLASSIFICATION ACCURACY; PERFORMANCE
VALIDITY; LIKELIHOOD RATIOS; TEST FAILURE; TESTS
AB Objective: This research examined cutoff scores for MMPI-2 and MMPI-2-RF validity scales specifically developed to assess non-credible reporting of cognitive and/or somatic symptoms. The validity scales examined included the Response Bias Scale (RBS), the Symptom Validity Scales (FBS, FBS-r), Infrequent Somatic Responses scale (Fs), and the Henry-Heilbronner Indexes (HHI, HHI-r).
Method: Cutoffs were developed by comparing a psychometrically defined non-malingering group with three psychometrically defined malingering groups (probable, probable to definite, and definite malingering) and a group that combined all malingering groups. The participants in this research were drawn from a military sample consisting largely of patients with traumatic brain injury (mostly mild traumatic brain injury).
Results: Specificities for cutoffs of at least 0.90 are provided. Sensitivities, predictive values, and likelihood ratios are also provided.
Conclusions: RBS had the largest mean effect size (d) when the malingering groups were compared to the non-malingering group (d range = 1.23-1.58).
C1 [Jones, Alvin] Womack Army Med Ctr, 2817 Riley Rd,Bldg 4-2817, Ft Bragg, NC 29310 USA.
RP Jones, A (reprint author), Womack Army Med Ctr, Dept Behav Hlth, 2817 Riley Rd,Bldg 4-2817, Ft Bragg, NC 29310 USA.
EM alrobj@googlemail.com
NR 81
TC 0
Z9 0
U1 1
U2 1
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0887-6177
EI 1873-5843
J9 ARCH CLIN NEUROPSYCH
JI Arch. Clin. Neuropsychol.
PD NOV
PY 2016
VL 31
IS 7
BP 786
EP 801
DI 10.1093/arclin/acw035
PG 16
WC Psychology, Clinical; Psychology
SC Psychology
GA EC2PH
UT WOS:000387965300010
ER
PT J
AU Batts, SG
Mu, TS
Uyehara-Lock, JH
Murata, LA
Uyehara, CFT
AF Batts, Sherreen G.
Mu, Thornton S.
Uyehara-Lock, Jane H.
Murata, Lee-Ann
Uyehara, Catherine F. T.
TI ECMO Maintains Cerebral Blood Flow During Endotoxic Shock in Piglets
SO ASAIO JOURNAL
LA English
DT Article
DE ECMO; cerebral blood flow; endotoxic shock
ID EXTRACORPOREAL MEMBRANE-OXYGENATION; NEAR-INFRARED SPECTROSCOPY;
CARDIOPULMONARY BYPASS; TISSUE OXYGENATION; CAROTID-ARTERY; PORCINE
MODEL; LIFE-SUPPORT; HEMODYNAMICS; VENOARTERIAL; INDUCTION
AB Cerebrovascular injury while on extracorporeal membrane oxygenation (ECMO) may be caused by excessive brain perfusion during hypoxemic reperfusion. Previous studies have postulated that the most vulnerable period of time for cerebrovascular injury is during the transfer period to ECMO. Therefore, our objective was to compare brain perfusion and hemodynamics in a piglet endotoxic shock ECMO model. The effect of ECMO flow on microcirculation of different brain regions was compared between 10 control pigs and six pigs (7-10 kg) administered IV endotoxin to achieve a drop in mean arterial blood pressure (MAP) of at least 30%. Cardiac output (CO), brain oxygen utilization, and microcirculatory blood flow (BF) were compared at baseline and 2 hours after ECMO stabilization. Matching ECMO delivery with baseline CO in control animals increased perfusion (p < 0.05) in all areas of the brain. In contrast, with endotoxin, ECMO returned perfusion closer to baseline levels in all regions of the brain and maintained brain tissue oxygen consumption. Both control and endotoxic pigs showed no evidence of acute neuronal necrosis in histologic cerebral cortical sections examined after 2 hours of ECMO. Results show that during endotoxic shock, transition to ECMO can maintain brain BF equally to all brain regions without causing overperfusion, and does not appear to cause brain tissue histopathologic changes (hemorrhage or necrosis) during the acute stabilization period after ECMO induction.
C1 [Batts, Sherreen G.] Tripler Army Med Ctr, Dept Pediat, Honolulu, HI 96859 USA.
[Mu, Thornton S.] JBSA Ft Sam Houston, Dept Pediat, Brooke Army Med Ctr, San Antonio, TX USA.
[Uyehara-Lock, Jane H.] Univ Hawaii, John A Burns Sch Med, Dept Pathol, Honolulu, HI 96822 USA.
[Murata, Lee-Ann; Uyehara, Catherine F. T.] Tripler Army Med Ctr, Dept Clin Invest, Honolulu, HI 96859 USA.
RP Mu, TS (reprint author), Dept Pediat, 3551 Roger Brooke Dr JBSA, San Antonio, TX 78234 USA.
EM thornton.s.mu.mil@mail.mil
FU US Army Medical Research and Materiel Command Congressionally Directed
Medical Research Program Grant [W23RYX6200N602]
FX Supported by US Army Medical Research and Materiel Command
Congressionally Directed Medical Research Program Grant W23RYX6200N602.
NR 24
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1058-2916
EI 1538-943X
J9 ASAIO J
JI Asaio J.
PD NOV-DEC
PY 2016
VL 62
IS 6
BP 732
EP 736
DI 10.1097/MAT.0000000000000413
PG 5
WC Engineering, Biomedical; Transplantation
SC Engineering; Transplantation
GA EC1OX
UT WOS:000387876500021
PM 27442858
ER
PT J
AU Billings, ME
Johnson, DA
Simonelli, G
Moore, K
Patel, SR
Roux, AVD
Redline, S
AF Billings, Martha E.
Johnson, Dayna A.
Simonelli, Guido
Moore, Kari
Patel, Sanjay R.
Roux, Ana V. Diez
Redline, Susan
TI Neighborhood Walking Environment and Activity Level Are Associated With
OSA The Multi-Ethnic Study of Atherosclerosis
SO CHEST
LA English
DT Article
DE activity; neighborhood; OSA
ID OBSTRUCTIVE SLEEP-APNEA; BODY-MASS INDEX; ROSTRAL FLUID SHIFT;
PHYSICAL-ACTIVITY; BUILT ENVIRONMENT; CARDIOVASCULAR-DISEASE;
RISK-FACTOR; WALKABILITY; ADULTS; OBESITY
AB BACKGROUND: There has been growing interest in understanding how neighborhoods may be related to cardiovascular risk. Neighborhood effects on sleep apnea could be one contributing mechanism. We investigated whether neighborhood walking environment and personal activity levels are related to OSA.
METHODS: Data were analyzed from a subpopulation of the Multi-Ethnic Study of Atherosclerosis (MESA), including subjects who participated in both the MESA Sleep and Neighborhood studies (N - 1,896). Perceived neighborhood walking environment and subjects' objective activity were evaluated in multivariate, multilevel models to determine any association with sleep apnea severity as defined by using the apnea-hypopnea index. Sex, race/ethnicity, and obesity were examined as moderators.
RESULTS: Residing in the lowest quartile walking environment neighborhoods (score < 3.75) was associated with more severe sleep apnea (mean, 2.7 events/h greater AHI [95% CI, 0.7 to 4.6]), after adjusting for demographic characteristics, BMI, comorbidities, health behaviors, neighborhood socioeconomic status, and site. Associations were stronger among obese and male individuals. Approximately 1 SD greater objective activity in men was associated with a lower AHI (mean, -2.4 events/h [95% CI, -3.5 to -1.3]). This association was partially mediated by BMI (P < .001).
CONCLUSIONS: Living in neighborhoods with a low walking environment score is associated with greater severity of sleep apnea, especially in male and obese individuals. In men, greater activity level is associated with less severe sleep apnea, independent of BMI, comorbidities, and socioeconomic status. Neighborhood-level interventions that increase walkability and enable increased physical activity may potentially reduce the severity of sleep apnea.
C1 [Billings, Martha E.] Univ Washington, Div Pulm Crit Care, UW Med Sleep Ctr, Seattle, WA 98195 USA.
[Johnson, Dayna A.; Redline, Susan] Harvard Med Sch, Brigham & Womens Hosp, Beth Israel Deaconess Med Ctr, Dept Med, Boston, MA USA.
[Simonelli, Guido] Walter Reed Army Inst Res, Behav Biol Branch, Silver Spring, MD USA.
[Moore, Kari; Roux, Ana V. Diez] Drexel Univ, Dornsife Sch Publ Hlth, Dept Epidemiol & Biostat, Philadelphia, PA 19104 USA.
[Patel, Sanjay R.] Univ Pittsburgh, Dept Med, Div Pulm Allergy & Crit Care Med, Pittsburgh, PA USA.
RP Billings, ME (reprint author), Univ Washington, Div Pulm Crit Care Med, UW Med Sleep Ctr Harborview, 325 Ninth Ave,Box 359803, Seattle, WA 98104 USA.
EM mebillin@uw.edu
FU National Heart, Lung and Blood Institute (NHLBI) at the National
Institutes of Health [N01-HC-95159, N01-HC-95169]; National Center for
Research Resources [UL1-TR-000040, UL1-TR-001079]; NHLBI [R01 HL071759,
R01 L098433]
FX This research was supported by the National Heart, Lung and Blood
Institute (NHLBI) at the National Institutes of Health through contracts
N01-HC-95159 through N01-HC-95169 and by grants UL1-TR-000040 and
UL1-TR-001079 from the National Center for Research Resources.
Additional funding for the ancillary MESA Neighborhood Study was
provided by NHLBI grant R01 HL071759 (A. V. D. R.) and for the ancillary
MESA Sleep Study from NHLBI grant R01 L098433 (S. R.).
NR 58
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PU AMER COLL CHEST PHYSICIANS
PI GLENVIEW
PA 2595 PATRIOT BLVD, GLENVIEW, IL 60026 USA
SN 0012-3692
J9 CHEST
JI Chest
PD NOV
PY 2016
VL 150
IS 5
BP 1042
EP 1049
DI 10.1016/j.chest.2016.06.012
PG 8
WC Critical Care Medicine; Respiratory System
SC General & Internal Medicine; Respiratory System
GA EB2RD
UT WOS:000387208600015
PM 27327117
ER
PT J
AU Brown, AM
Zifchock, RA
Hillstrom, HJ
Song, J
Tucker, CA
AF Brown, Allison M.
Zifchock, Rebecca A.
Hillstrom, Howard J.
Song, Jinsup
Tucker, Carole A.
TI The effects of fatigue on lower extremity kinematics, kinetics and joint
coupling in symptomatic female runners with iliotibial band syndrome
SO CLINICAL BIOMECHANICS
LA English
DT Article
DE Running injury; Fatigue; Hip; Vector coding
ID GROUND REACTION FORCES; RUNNING BIOMECHANICS; FRICTION SYNDROME;
DISTANCE RUNNERS; EXHAUSTIVE RUN; MECHANICS; INJURIES; VARIABILITY;
ETIOLOGY; HISTORY
AB Background: Altered hip and knee kinematics and joint coupling have been documented in runners with iliotibial band syndrome. Symptoms often present themselves after several minutes of running, yet the effect of fatigue warrants further exploration. The purpose of this study was to determine the effect of a run to fatigue in runners with iliotibial band syndrome, as compared to healthy controls.
Methods: Twenty uninjured and 12 female runners with iliotibial band syndrome performed a treadmill run to fatigue. Prior-to and following a run to fatigue, overground running data were collected. Variables of interest included stance phase: peak hip adduction and internal rotation, peak hip abductor and external rotator joint moments and frontal-sagittal plane hip and knee joint coupling.
Findings: Fatigue resulted in decreased peak hip adduction angles in injured runners. Fatigue did not affect injured runners differently than controls with respect to the remaining variables. Coupling differences did not exist between healthy and injured runners with respect to the loading or propulsive phases of stance.
Interpretation: While clinicians often strengthen hip abductor muscles and provide gait re-training to decrease stance phase hip adduction, our results suggest that, when exerted, female runners with iliotibial band syndrome independently modify their running gait to decrease hip adduction, potentially as a result of pain. Fatigue did not have an effect on the remaining study variables. It is possible that reducing the length of the iliotibial band through minimizing hip adduction reduces pain, but the other variables examined are not sensitive to this phenomenon. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Brown, Allison M.] Rutgers Biomed & Hlth Sci, Dept Rehabil & Movement Sci, Newark, NJ USA.
[Zifchock, Rebecca A.] US Mil Acad, Dept Civil & Mech Engn, West Point, NY 10996 USA.
[Hillstrom, Howard J.] Hosp Special Surg, MD Mot Anal Lab, Leon Root, 535 E 70th St, New York, NY 10021 USA.
[Song, Jinsup] Temple Univ, Gait Study Ctr, Sch Podiatr Med, Philadelphia, PA 19122 USA.
[Tucker, Carole A.] Temple Univ, Dept Phys Therapy, Philadelphia, PA 19122 USA.
RP Brown, AM (reprint author), Rutgers Biomed & Hlth Sci, Sch Hlth Related Profess, Dept Rehabil & Movement Sci, 65 Bergen St,Room 714, Newark, NJ 07107 USA.
EM allison.m.brown@rutgers.edu
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PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0268-0033
EI 1879-1271
J9 CLIN BIOMECH
JI Clin. Biomech.
PD NOV
PY 2016
VL 39
BP 84
EP 90
DI 10.1016/j.clinbiomech.2016.09.012
PG 7
WC Engineering, Biomedical; Orthopedics; Sport Sciences
SC Engineering; Orthopedics; Sport Sciences
GA EC1AB
UT WOS:000387834800013
PM 27718393
ER
PT J
AU Barr, R
Moser, A
Rusnak, S
Zimmermann, L
Dickerson, K
Lee, H
Gerhardstein, P
AF Barr, Rachel
Moser, Alecia
Rusnak, Sylvia
Zimmermann, Laura
Dickerson, Kelly
Lee, Herietta
Gerhardstein, Peter
TI The impact of memory load and perceptual cues on puzzle learning by
24-month olds
SO DEVELOPMENTAL PSYCHOBIOLOGY
LA English
DT Article
DE imitation; toddlers; learning; memory; sex differences
ID AGE-RELATED-CHANGES; SHORT-TERM-MEMORY; DEFERRED IMITATION; INFANT
MEMORY; DEVELOPMENTAL-CHANGES; ACTION SEQUENCES; EARLY-CHILDHOOD; SERIAL
LIST; CHILDREN; RECALL
AB Early childhood is characterized by memory capacity limitations and rapid perceptual and motor development [Rovee-Collier (1996). Infant Behavior & Development, 19, 385-400]. The present study examined 2-year olds' reproduction of a sliding action to complete an abstract fish puzzle under different levels of memory load and perceptual feature support. Experimental groups were compared to baseline controls to assess spontaneous rates of production of the target actions; baseline production was low across all experiments. Memory load was manipulated in Exp. 1 by adding pieces to the puzzle, increasing sequence length from 2 to 3 items, and to 3 items plus a distractor. Although memory load did not influence how toddlers learned to manipulate the puzzle pieces, it did influence toddlers' achievement of the goal-constructing the fish. Overall, girls were better at constructing the puzzle than boys. In Exp. 2, the perceptual features of the puzzle were altered by changing shape boundaries to create a two-piece horizontally cut puzzle (displaying bilateral symmetry), and by adding a semantically supportive context to the vertically cut puzzle (iconic). Toddlers were able to achieve the goal of building the fish equally well across the 2-item puzzle types (bilateral symmetry, vertical, iconic), but how they learned to manipulate the puzzle pieces varied as a function of the perceptual features. Here, as in Exp. 1, girls showed a different pattern of performance from the boys. This study demonstrates that changes in memory capacity and perceptual processing influence both goal-directed imitation learning and motoric performance.
C1 [Barr, Rachel; Rusnak, Sylvia; Zimmermann, Laura; Lee, Herietta] Georgetown Univ, Dept Psychol, 3700 O St NW, Washington, DC 20057 USA.
[Moser, Alecia; Gerhardstein, Peter] SUNY Binghamton, Dept Psychol, Binghamton, NY USA.
[Dickerson, Kelly] US Army Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD USA.
RP Barr, R (reprint author), Georgetown Univ, Dept Psychol, 3700 O St NW, Washington, DC 20057 USA.
EM rfb5@georgetown.edu
FU NSF [BSC-1023772]
FX This research was supported by NSF (BSC-1023772).
NR 57
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PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0012-1630
EI 1098-2302
J9 DEV PSYCHOBIOL
JI Dev. Psychobiol.
PD NOV
PY 2016
VL 58
IS 7
BP 817
EP 828
DI 10.1002/dev.21450
PG 12
WC Developmental Biology; Psychology
SC Developmental Biology; Psychology
GA EC1KQ
UT WOS:000387863900004
PM 27753456
ER
PT J
AU Bartos, M
Chester, M
Johnson, N
Gorman, B
Eisenberg, D
Linkov, I
Bates, M
AF Bartos, Matthew
Chester, Mikhail
Johnson, Nathan
Gorman, Brandon
Eisenberg, Daniel
Linkov, Igor
Bates, Matthew
TI Impacts of rising air temperatures on electric transmission ampacity and
peak electricity load in the United States
SO ENVIRONMENTAL RESEARCH LETTERS
LA English
DT Article
DE climate change; infrastructure; resilience; electrical grid
ID CLIMATE-CHANGE; ENERGY-CONSUMPTION; DEMAND; RESILIENCE; MITIGATION;
BUILDINGS; DATASET; TRENDS; MARKET
AB Climate change may constrain future electricity supply adequacy by reducing electric transmission capacity and increasing electricity demand. The carrying capacity of electric power cables decreases as ambient air temperatures rise; similarly, during the summer peak period, electricity loads typically increase with hotter air temperatures due to increased air conditioning usage. As atmospheric carbon concentrations increase, higher ambient air temperatures may strain power infrastructure by simultaneously reducing transmission capacity and increasing peak electricity load. We estimate the impacts of rising ambient air temperatures on electric transmission ampacity and peak per-capita electricity load for 121 planning areas in the United States using downscaled global climate model projections. Together, these planning areas account for roughly 80% of current peak summertime load. We estimate climate-attributable capacity reductions to transmission lines by constructing thermal models of representative conductors, then forcing these models with future temperature projections to determine the percent change in rated ampacity. Next, we assess the impact of climate change on electricity load by using historical relationships between ambient temperature and utility-scale summertime peak load to estimate the extent to which climate change will incur additional peak load increases. We find that by mid-century (2040-2060), increases in ambient air temperature may reduce average summertime transmission capacity by 1.9%-5.8% relative to the 1990-2010 reference period. At the same time, peak per-capita summertime loads may rise by 4.2%-15% on average due to increases in ambient air temperature. In the absence of energy efficiency gains, demand-side management programs and transmission infrastructure upgrades, these load increases have the potential to upset current assumptions about future electricity supply adequacy.
C1 [Bartos, Matthew; Chester, Mikhail; Gorman, Brandon; Eisenberg, Daniel] Arizona State Univ, Dept Civil Environm & Sustainable Engn, Tempe, AZ 85287 USA.
[Johnson, Nathan] Arizona State Univ, Ira A Fulton Sch Engn, Polytech Sch, Tempe, AZ 85287 USA.
[Eisenberg, Daniel; Linkov, Igor; Bates, Matthew] US Army, Engn Res & Dev Ctr, Vicksburg, MS USA.
RP Bartos, M (reprint author), Arizona State Univ, Dept Civil Environm & Sustainable Engn, Tempe, AZ 85287 USA.
EM mdbartos@umich.edu; mchester@asu.edu; nathanjohnson@asu.edu;
btgorman@asu.edu; daeisenb@asu.edu; igor.linkov@usace.army.mil;
matthew.e.bates@usace.army.mil
FU National Science Foundation [WSC 1360509, IMEE 1335556, RIPS 1441352];
USACE Military Programs
FX This material is based on work supported by the National Science
Foundation (grant numbers WSC 1360509, IMEE 1335556, and RIPS 1441352).
This work was supported in parts by the USACE Military Programs.
Permission was granted by the authority of the USACE Chief of Engineers
to publish this material. The views and opinions expressed in this
article are those of the individual authors and not those of the U.S.
Army or other sponsor organizations.
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PU IOP PUBLISHING LTD
PI BRISTOL
PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
SN 1748-9326
J9 ENVIRON RES LETT
JI Environ. Res. Lett.
PD NOV
PY 2016
VL 11
IS 11
AR 114008
DI 10.1088/1748-9326/11/11/114008
PG 13
WC Environmental Sciences; Meteorology & Atmospheric Sciences
SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences
GA EC0UH
UT WOS:000387815800001
ER
PT J
AU Hoge, CW
AF Hoge, Charles W.
TI Changes to the Definition of Posttraumatic Stress Disorder in the DSM-5
Reply
SO JAMA PSYCHIATRY
LA English
DT Letter
C1 [Hoge, Charles W.] Walter Reed Army Inst Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
RP Hoge, CW (reprint author), Walter Reed Army Inst Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM charles.w.hoge.civ@mail.mil
NR 4
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U1 1
U2 1
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 2168-622X
EI 2168-6238
J9 JAMA PSYCHIAT
JI JAMA Psychiatry
PD NOV
PY 2016
VL 73
IS 11
BP 1202
EP 1203
DI 10.1001/jamapsychiatry.2016.2381
PG 2
WC Psychiatry
SC Psychiatry
GA EC2GJ
UT WOS:000387927400020
PM 27732717
ER
PT J
AU Kesavan, J
Stephens, A
Kesavan, M
AF Kesavan, Jana
Stephens, Amelia
Kesavan, Meera
TI Bacterial Cross-contamination Potential Associated with Contaminated
Currency
SO JOURNAL OF FORENSIC SCIENCES
LA English
DT Article
DE forensic science; spread of disease; contaminated currency; bacteria;
Bacillus thuringiensis; cross-contamination
ID PAPER; SURVIVAL; HANDS; EFFICIENCY; FOMITES
AB Previous studies have shown a significant amount of contaminants on paper currencies. It is important to study the transfer of microorganisms between paper currencies to determine whether it meets the level of a human health threat. This cross-contamination potential was analyzed by seeding new US 1-dollar bills with Bacillus thuringiensis, and pressing or rubbing them against clean currency to determine the amount of bacteria transfer to the unseeded currency. The transferred amount of bacteria was recovered, plated, incubated, and the colony-forming units were quantified. Among the recovery methods tested, the most efficient method, vortexing for 10 min with a recovery efficiency of 40 +/- 8.1%, was used in this analysis. The resulting transfer rates were 4.8%, 8.6%, and 14.3% when pressed for 24 h, 72 h, and rubbed together, respectively. These transferred amounts of bacteria are significant and have the potential to spread infectious diseases.
C1 [Kesavan, Jana; Stephens, Amelia; Kesavan, Meera] US Army, Edgewood Chem Biol Ctr, RDCB DRI T E5951,5183 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA.
RP Kesavan, J (reprint author), US Army, Edgewood Chem Biol Ctr, RDCB DRI T E5951,5183 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA.
EM Jana.S.Kesavan.civ@mail.mil
NR 21
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U1 3
U2 3
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-1198
EI 1556-4029
J9 J FORENSIC SCI
JI J. Forensic Sci.
PD NOV
PY 2016
VL 61
IS 6
BP 1639
EP 1642
DI 10.1111/1556-4029.13174
PG 4
WC Medicine, Legal
SC Legal Medicine
GA EB8SI
UT WOS:000387660800031
PM 27539663
ER
PT J
AU Henry, TC
Bakis, CE
AF Henry, Todd C.
Bakis, Charles E.
TI Compressive strength and stiffness of filament-wound cylinders
SO JOURNAL OF REINFORCED PLASTICS AND COMPOSITES
LA English
DT Article
DE Homogenization; filament-wound composite; fiber undulation; elastic
modulus; strength
ID WOVEN FABRIC COMPOSITES; ELASTIC-CONSTANTS; FIBER COMPOSITES; PLY
WAVINESS; REDUCTION; BEHAVIOR; MODELS
AB In filament-wound composites, the existence of fiber undulation introduces unique challenges in the calculation of compressive modulus and strength using traditional composite theories. In the current work, a previously developed three-dimensional continuum representation of undulated fibers was incorporated into a multi-scale homogenization process to simulate the effective longitudinal stress-strain behavior of filament-wound cylinders and compressive failure in the undulation regions. Calculated properties were compared to previously obtained experimental data for carbon fiber cylinders made with various matrix materials and winding parameters. The average difference between predicted and measured properties was 14% and the predicted failure modes were consistent with the experimental observations.
C1 [Henry, Todd C.] US Army Res Lab, Vehicle Technol Directorate, Adelphi, MD USA.
[Bakis, Charles E.] Penn State Univ, Dept Engn Sci & Mech, University Pk, PA 16802 USA.
RP Henry, TC (reprint author), Army Res Lab, 4603 Flare Loop, Aberdeen, MD 21005 USA.
EM todd.c.henry2.civ@mail.mil
FU US Department of Defense
FX The author(s) disclosed receipt of the following financial support for
the research, authorship, and/or publication of this article: The US
Department of Defense is acknowledged for the financial support of the
first author through the SMART Fellowship.
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PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0731-6844
EI 1530-7964
J9 J REINF PLAST COMP
JI J. Reinf. Plast. Compos.
PD NOV
PY 2016
VL 35
IS 21
BP 1543
EP 1553
DI 10.1177/0731684416659545
PG 11
WC Materials Science, Composites; Polymer Science
SC Materials Science; Polymer Science
GA EA8AH
UT WOS:000386854600002
ER
PT J
AU Holloway, TL
Nicholson, SE
Rani, M
Cap, AP
Schwacha, MG
AF Holloway, Travis L.
Nicholson, Susannah E.
Rani, Meenakshi
Cap, Andrew P.
Schwacha, Martin G.
TI Toll-like receptor responses are suppressed in trauma ICU patients
SO JOURNAL OF SURGICAL RESEARCH
LA English
DT Article
DE Cytokines; Inflammation; Whole blood; PAMPs; DAMPS
ID MULTIPLE ORGAN FAILURE; INFLAMMATORY RESPONSE; IMMUNE-RESPONSES; INJURY;
CELLS; RECOGNITION; MECHANISMS; MANAGEMENT; INFECTION; DISEASE
AB Background: Inflammation and activation of the innate immune system are often associated with traumatic injury and may involve alterations in toll-like receptor (TLR)-mediated responses.
Methods: A prospective observational study was designed and conducted. Twenty-one severely injured (ISS = 16-41) trauma intensive care unit (ICU) patients and six healthy volunteers that served as controls were enrolled. Anticoagulated whole blood was collected at 2-12 d after ICU admission and incubated in the presence of media alone (baseline), zymosan (TLR2 agonist) or lipopolysaccharide (LPS; TLR4 agonist) for 3 h. Supernatant levels of inflammatory cytokines (IL-1 beta, IL-6, IL-10, and TNF alpha) were determined.
Results: TLR2-mediated and TLR4-mediated activation of whole blood cell cultures from both healthy volunteers and subjects-induced elevated cytokine levels over that observed in unstimulated cultures. Baseline values of IL-6 were significantly elevated in subject cultures as compared to healthy volunteers. Healthy volunteer cultures had 2-3-fold greater levels of IL-6 and TNF alpha than subject cultures when stimulated with zymosan (TLR2 agonist) or LPS (TLR4 agonist). IL-1 beta and IL-10 levels did not differ significantly between healthy volunteers and subjects.
Conclusions: The ability of circulating leukocytes from trauma ICU patients to be activated by TLR agonists is markedly suppressed and may play a role in the development of subsequent infectious complications. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Holloway, Travis L.; Nicholson, Susannah E.; Rani, Meenakshi; Cap, Andrew P.; Schwacha, Martin G.] Univ Texas Hlth Sci Ctr San Antonio, Dept Surg, 7703 Floyd Curl Dr, San Antonio, TX 78229 USA.
[Cap, Andrew P.; Schwacha, Martin G.] US Army, Inst Surg Res, Blood Res, JBSA Ft Sam Houston, Ft Knox, KY USA.
RP Schwacha, MG (reprint author), Univ Texas Hlth Sci Ctr San Antonio, Dept Surg, 7703 Floyd Curl Dr, San Antonio, TX 78229 USA.
EM schwacha@uthscsa.edu
FU NIH [5T32GM079085]; NIH/NCRR [UL 1RR025767]; NIH-NCI [P30 CA54174];
[UL1RR025767]
FX Travis L Holloway, MD was supported by NIH grant 5T32GM079085 and the
project was in part supported by NIH/NCRR UL 1RR025767, NIH-NCI P30
CA54174 and UL1RR025767. These finding were presented in part at the
36th annual meeting of the Shock Society in San Diego CA. The authors
wish to acknowledge the excellent technical assistance of Teresa Craig
and Qiong Zhang. The opinions or assertions contained herein are the
private views of the author and are not to be construed as official or
as reflecting the views of the Department of the Army or the Department
of Defense.
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PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0022-4804
EI 1095-8673
J9 J SURG RES
JI J. Surg. Res.
PD NOV
PY 2016
VL 206
IS 1
BP 139
EP 145
DI 10.1016/j.jss.2016.06.056
PG 7
WC Surgery
SC Surgery
GA EC2VR
UT WOS:000387982900022
PM 27916353
ER
PT J
AU Goldberg, CS
Turner, CR
Deiner, K
Klymus, KE
Thomsen, PF
Murphy, MA
Spear, SF
McKee, A
Oyler-McCance, SJ
Cornman, RS
Laramie, MB
Mahon, AR
Lance, RF
Pilliod, DS
Strickler, KM
Waits, LP
Fremier, AK
Takahara, T
Herder, JE
Taberlet, P
AF Goldberg, Caren S.
Turner, Cameron R.
Deiner, Kristy
Klymus, Katy E.
Thomsen, Philip Francis
Murphy, Melanie A.
Spear, Stephen F.
McKee, Anna
Oyler-McCance, Sara J.
Cornman, Robert Scott
Laramie, Matthew B.
Mahon, Andrew R.
Lance, Richard F.
Pilliod, David S.
Strickler, Katherine M.
Waits, Lisette P.
Fremier, Alexander K.
Takahara, Teruhiko
Herder, Jelger E.
Taberlet, Pierre
TI Critical considerations for the application of environmental DNA methods
to detect aquatic species
SO METHODS IN ECOLOGY AND EVOLUTION
LA English
DT Review
DE biodiversity; eDNA; invasive species; non-destructive sampling;
quantitative PCR; reporting guidelines
ID POLYMERASE-CHAIN-REACTION; REAL-TIME PCR; WATER SAMPLES; DETECTION
PROBABILITIES; MONITORING PROGRAM; EXTRACELLULAR DNA; SILVER CARP; EDNA;
EXTRACTION; GUIDELINES
AB Species detection using environmental DNA (eDNA) has tremendous potential for contributing to the understanding of the ecology and conservation of aquatic species. Detecting species using eDNA methods, rather than directly sampling the organisms, can reduce impacts on sensitive species and increase the power of field surveys for rare and elusive species. The sensitivity of eDNA methods, however, requires a heightened awareness and attention to quality assurance and quality control protocols. Additionally, the interpretation of eDNA data demands careful consideration of multiple factors. As eDNA methods have grown in application, diverse approaches have been implemented to address these issues. With interest in eDNA continuing to expand, supportive guidelines for undertaking eDNA studies are greatly needed. Environmental DNA researchers from around the world have collaborated to produce this set of guidelines and considerations for implementing eDNA methods to detect aquatic macroorganisms. Critical considerations for study design include preventing contamination in the field and the laboratory, choosing appropriate sample analysis methods, validating assays, testing for sample inhibition and following minimum reporting guidelines. Critical considerations for inference include temporal and spatial processes, limits of correlation of eDNA with abundance, uncertainty of positive and negative results, and potential sources of allochthonous DNA. We present a synthesis of knowledge at this stage for application of this new and powerful detection method.
C1 [Goldberg, Caren S.; Strickler, Katherine M.; Fremier, Alexander K.] Washington State Univ, Sch Environm, 100 Dairy Rd, Pullman, WA 99164 USA.
[Turner, Cameron R.; Deiner, Kristy] Univ Notre Dame, Dept Biol Sci, Notre Dame, IN 46556 USA.
[Klymus, Katy E.] Univ Toledo, Lake Erie Ctr, 6200 Bayshore Rd, Oregon, OH 43616 USA.
[Thomsen, Philip Francis] Univ Copenhagen, Nat Hist Museum Denmark, Ctr GeoGenet, Oster Voldgade 5-7, DK-1350 Copenhagen, Denmark.
[Murphy, Melanie A.] Univ Wyoming, Dept Ecosyst Sci & Management, Program Ecol, Dept 3354, 1000 E Univ Ave, Laramie, WY 82071 USA.
[Spear, Stephen F.] Orianne Soc, 100 Phoenix Rd, Athens, GA 30605 USA.
[McKee, Anna] US Geol Survey, South Atlantic Water Sci Ctr, 1770 Corp Dr Suite 500, Norcross, GA 30093 USA.
[Oyler-McCance, Sara J.; Cornman, Robert Scott] US Geol Survey, Ft Collins Sci Ctr, 2150 Ctr Ave,Bldg C, Ft Collins, CO 80526 USA.
[Laramie, Matthew B.; Pilliod, David S.] US Geol Survey, Forest & Rangeland Ecosyst Sci Ctr, Boise, ID 83706 USA.
[Mahon, Andrew R.] Cent Michigan Univ, Dept Biol, Inst Great Lakes Res, Mt Pleasant, MI 48859 USA.
[Lance, Richard F.] US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA.
[Waits, Lisette P.] Univ Idaho, Fish & Wildlife Sci, Moscow, ID 83844 USA.
[Takahara, Teruhiko] Shimane Univ, Fac Life & Environm Sci, 1060 Nishikawatsu, Matsue, Shimane 6908504, Japan.
[Herder, Jelger E.] Reptile Amphibian & Fish Conservat Netherlands RA, POB 1413, NL-6501 BK Nijmegen, Netherlands.
[Taberlet, Pierre] Univ Grenoble Alpes, Lab Ecol Alpine, F-38000 Grenoble, France.
[Turner, Cameron R.] EcoSyst Genet LLC EcoSysGen, POB 8316, South Bend, IN 46660 USA.
RP Goldberg, CS (reprint author), Washington State Univ, Sch Environm, 100 Dairy Rd, Pullman, WA 99164 USA.
EM caren.goldberg@wsu.edu
OI Thomsen, Philip Francis/0000-0002-9867-4366
FU Department of Defense Environmental Security Technology Certification
Program [RC-201204, RC-201205]; Danish National Research Foundation; NSF
[EPS-1208909]; Wyoming EPSCOR WyCEHG seed grant; NSF IGERT award
[0504495]; US DoD SERDP [RC-2240]; Dutch Network Ecological Monitoring;
Rijkswaterstaat; NVWA; STOWA; Dutch Waterboards
FX This manuscript is a product of collaborations that formed as a result
of a symposium on environmental DNA that occurred at the 2013
International Congress for Conservation Biology in Maryland, USA. CSG,
KMS, AKF and LPW were supported in part by the Department of Defense
Environmental Security Technology Certification Program (RC-201204 and
RC-201205). PFT was supported by the Danish National Research
Foundation. MAM was supported in part by NSF grant # EPS-1208909 and
Wyoming EPSCOR WyCEHG seed grant. CRT was supported in part by NSF IGERT
award 0504495. KD was supported in part by US DoD SERDP RC-2240. JEH was
supported by the Dutch Network Ecological Monitoring, Rijkswaterstaat,
NVWA, STOWA and several Dutch Waterboards. PT is co-inventor of several
patents concerning the DNA-based identification of plants, vertebrates,
amphibians, fishes and earthworms. These patents only restrict
commercialapplications and have no impact on the use of themethod by
academic researchers. PT is member of the scientific committee of the
SPYGEN company (http://www.spygen.com). CRT is currently a scientist in
a commercial company, ecoSysGen, which specializes in genetic and
genomic analysis of environmental mixtures for ecosystem monitoring. CRT
did not receive funding from ecoSysGen, while this study was conducted.
We thank E. Monroe and two anonymous reviewers for insightful feedback.
Any use of trade, firm or product names is for descriptive purposes only
and does not imply endorsement by the U.S. Government.
NR 75
TC 4
Z9 4
U1 46
U2 46
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2041-210X
EI 2041-2096
J9 METHODS ECOL EVOL
JI Methods Ecol. Evol.
PD NOV
PY 2016
VL 7
IS 11
BP 1299
EP 1307
DI 10.1111/2041-210X.12595
PG 9
WC Ecology
SC Environmental Sciences & Ecology
GA EB8VO
UT WOS:000387669600005
ER
PT J
AU Russell, DW
Benedek, DM
Naifeh, JA
Fullerton, CS
Benevides, N
Ursano, RJ
Russell, CA
Forsten, RD
Cacciopo, JT
AF Russell, Dale W.
Benedek, David M.
Naifeh, James A.
Fullerton, Carol S.
Benevides, Nikki
Ursano, Robert J.
Russell, Cristel A.
Forsten, Robert D.
Cacciopo, John T.
TI Social Support and Mental Health Outcomes Among US Army Special
Operations Personnel
SO MILITARY PSYCHOLOGY
LA English
DT Article
DE military; mental health; social support; PTSD; Special Forces
ID POSTTRAUMATIC-STRESS-DISORDER; RISK-FACTORS; PHYSIOLOGICAL PROCESSES;
DEPRESSION SYMPTOMS; MILITARY PERSONNEL; COMBAT EXPOSURE; LIFE EVENTS;
MORALE; VETERANS; COHESION
AB Mental health disorders continue to plague service members and veterans; thus, new approaches are required to help address such outcomes. The identification of risk and resilience factors for these disorders in specific populations can better inform both treatment and prevention strategies. This study focuses on a unique population of U.S. Army Special Operations personnel to assess how specific avenues of social support and personal morale are related to mental health outcomes. The results indicate that, whereas personal morale and friend support reduce the relationship between combat experiences and posttraumatic stress disorder (PTSD), strong unit support exacerbates the negative effects of combat experiences in relation to PTSD. The study thus shows that although informal social support can lessen postdeployment mental health concerns, military populations with strong internal bonds may be at greater risk of PTSD because the support that they receive from fellow service members may heighten the traumatic impact of combat experiences.
C1 [Russell, Dale W.; Benedek, David M.; Naifeh, James A.; Fullerton, Carol S.; Benevides, Nikki; Ursano, Robert J.] Uniformed Serv Univ Hlth Sci, Ctr Study Traumat Stress, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.
[Russell, Cristel A.] Amer Univ, Kogod Sch Business, Washington, DC 20016 USA.
[Forsten, Robert D.] US Army War Coll, Carlisle, PA USA.
[Cacciopo, John T.] Univ Chicago, Dept Psychol, Chicago, IL 60637 USA.
RP Russell, DW (reprint author), Uniformed Serv Univ Hlth Sci, Ctr Study Traumat Stress, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.
EM dale.russell@usuhs.edu
NR 75
TC 0
Z9 0
U1 6
U2 6
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0899-5605
EI 1532-7876
J9 MIL PSYCHOL
JI Milit. Psychol.
PD NOV
PY 2016
VL 28
IS 6
BP 361
EP 375
DI 10.1037/mil0000114
PG 15
WC Psychology, Multidisciplinary
SC Psychology
GA EC2PJ
UT WOS:000387965500001
ER
PT J
AU Paniagua, FA
Black, SA
Gallaway, MS
AF Paniagua, Freddy A.
Black, Sandra A.
Gallaway, M. Shayne
TI Psychometrics of Behavioral Health Screening Scales in Military Contexts
SO MILITARY PSYCHOLOGY
LA English
DT Article
DE PTSD; suicide; alcohol abuse; military psychologists; screening
ID POSTTRAUMATIC-STRESS-DISORDER; SERVICEMEMBERS ARMY STARRS;
NATIONAL-GUARD SOLDIERS; ADMINISTERED PTSD SCALE; MENTAL-HEALTH; COMBAT
EXPOSURE; EVENT SCALE; ASSESS RISK; INITIAL VALIDATION;
SUICIDAL-BEHAVIOR
AB A major task for military and civilian mental health practitioners is to screen United States service members/military personnel for an array of mental health problems (e.g., depression, alcohol abuse, suicidal ideation, posttraumatic stress disorder [PTSD]) before further assessment leading to diagnosis of mental disorders. During the assessment of such mental health problems, screening scales should be not only reliable and valid, but also have clinical utility in the military context. Busy clinicians may not have enough time to determine which screening scales meet minimal psychometric standards and proven clinical utility with predeployment or postdeployment soldiers on active duty. A sample of screening scales was identified during a thorough review of the peer-reviewed psychometric literature, textbooks on psychometrics, and the American Psychological Association PsycINFO database. Selection criteria (e.g., acceptable psychometric properties, previously used in the military context) resulted in the identification of 7 core (first-order description) screening scales recommended in the assessment of mental health problems within the military context. Core scales were organized across 4 clinical domains: general mental health functioning (e.g., Behavior and Symptom Identification Scale [BASIS]), self-harm and risk-taking behaviors (e.g., Suicide Intent Scale [SIS]), assessment of PTSD (e.g., PTSD Checklist [PCL]) and Anger Reactions (e.g., Dimension of Anger Reaction Scale [DAR]), and assessment of substance abuse/dependence (e.g., Alcohol Use Disorders Identification Test -AUDIT). For each core scale, alternative scales were also selected using similar selection criteria. Implications of the study findings for the practice of military and civilian psychologists in the Department of Defense (DoD) are discussed.
C1 [Paniagua, Freddy A.; Black, Sandra A.; Gallaway, M. Shayne] US Army Publ Hlth Command, Behav & Social Hlth Outcomes Program, Aberdeen Proving Ground, MD USA.
[Paniagua, Freddy A.] Univ Texas Med Branch, Galveston, TX 77555 USA.
[Gallaway, M. Shayne] US Army Garrison, US Army Substance Abuse Program, Ansbach, Germany.
RP Paniagua, FA (reprint author), 3100 North J St 38, Mcallen, TX 78501 USA.
EM faguapan@aol.com
FU U.S. Army Public Health Command
FX This research was supported with a Faculty Research Appointment given to
the first author by the U.S. Army Public Health Command, and coordinated
by the Oak Ridge Associated Universities. LTC Michael R. Bell was the
Director of the Behavioral Health Outcomes Programs when this study was
produced, and we thank him for providing the infrastructure leading to
the successful development of this article. The views expressed in this
article are those of the authors, and do not reflect the official policy
or position of the Department of the Army, the Department of Defense, or
the U.S. government.
NR 105
TC 0
Z9 0
U1 7
U2 7
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0899-5605
EI 1532-7876
J9 MIL PSYCHOL
JI Milit. Psychol.
PD NOV
PY 2016
VL 28
IS 6
BP 448
EP 467
DI 10.1037/mil0000140
PG 20
WC Psychology, Multidisciplinary
SC Psychology
GA EC2PJ
UT WOS:000387965500007
ER
PT J
AU Laurence, JH
Milavec, BL
Rohall, DE
Ender, MG
Matthews, MD
AF Laurence, Janice H.
Milavec, Briana L.
Rohall, David E.
Ender, Morten G.
Matthews, Michael D.
TI Predictors of Support for Women in Military Roles: Military Status,
Gender, and Political Ideology
SO MILITARY PSYCHOLOGY
LA English
DT Article
DE gender; military roles; combat jobs; Service Academy; conservativism
ID ATTITUDES; CONSERVATISM; AFFILIATION; CULTURE; WARS
AB The repeal of combat restrictions by gender raises the importance of understanding factors related to the acceptance of women serving in the full range of military jobs. Previous research shows military affiliated cadets, especially males, are substantially less approving of women serving in military jobs, especially those involving exposure to direct combat or command positions, than are other college students. The current study extends these findings by considering political ideology in addition to gender and military affiliation, as related to attitudes toward women's roles in the military overall and in combat roles in particular. Survey data from Service Academy cadets (n = 3,116), Reserve Officer Training Corps (ROTC) cadets (n = 1,367), and nonmilitary affiliated college students (n = 2,648), provided measures of whether a woman should or should not be allowed to serve in 9 different military job areas. In addition to overall approval, a scale for combat jobs was created from a subset of 4 of the jobs. Regression analysis indicated that once gender, political party, political position (left/right), and attitudes toward mothers in the workforce overall were controlled, type of college did not add to the prediction of acceptance of women in various military roles. In general, nonmilitary affiliated respondents, women, and those identifying as Democrat offered higher approval scores. Our findings suggest more aggressive programs, designed to educate and socialize these future leaders about women's roles in the military, may require development.
C1 [Laurence, Janice H.; Milavec, Briana L.] Temple Univ, Adult & Org Dev, Coll Educ, 1301 West Cecil B Moore Ave,Ritter Annex 229, Philadelphia, PA 19122 USA.
[Rohall, David E.] Missouri State Univ, Dept Sociol & Anthropol, Springfield, MO USA.
[Ender, Morten G.; Matthews, Michael D.] US Mil Acad, Dept Behav Sci & Leadership, West Point, NY 10996 USA.
RP Laurence, JH (reprint author), Temple Univ, Adult & Org Dev, Coll Educ, 1301 West Cecil B Moore Ave,Ritter Annex 229, Philadelphia, PA 19122 USA.
EM janice.laurence@temple.edu
NR 35
TC 0
Z9 0
U1 1
U2 1
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0899-5605
EI 1532-7876
J9 MIL PSYCHOL
JI Milit. Psychol.
PD NOV
PY 2016
VL 28
IS 6
BP 488
EP 497
DI 10.1037/mil0000142
PG 10
WC Psychology, Multidisciplinary
SC Psychology
GA EC2PJ
UT WOS:000387965500009
ER
PT J
AU Duan, WY
Zheng, K
Zhao, BB
Demirbilek, Z
Ertekin, RC
Webster, WC
AF Duan, W. Y.
Zheng, K.
Zhao, B. B.
Demirbilek, Z.
Ertekin, R. C.
Webster, W. C.
TI On wave-current interaction by the Green-Naghdi equations in shallow
water
SO NATURAL HAZARDS
LA English
DT Article
DE Wave-current interaction; Green-Naghdi theory; Shallow water waves;
Submerged bar
ID BOUSSINESQ-TYPE EQUATIONS; SURFACE-WAVES; PROPAGATION; BOTTOM; DEPTH;
MODEL; FORM
AB This work is on the use of the Green-Naghdi (GN) nonlinear wave equations for simulating wave-current interaction in shallow water. The stream-function wave theory is used at the wave-maker boundary to generate nonlinear incident waves to consider the wave-current interaction. The nonlinear GN equations are solved in the time domain by use of the finite-difference method. The model is evaluated with data from three experimental studies. A strong opposing current over a submerged bar is investigated in the first test case. In the second test case, the interaction of waves with a uniform current over flat bottom is considered. In the third case, wave-current interaction over a variable bathymetry with the following and opposing currents is studied. The numerical results obtained by the GN equations are compared with the experimental data and results based on the Boussinesq equations. A good agreement is obtained for the three experimental studies considered for a wide range of wave and current conditions.
C1 [Duan, W. Y.; Zheng, K.; Zhao, B. B.] Harbin Engn Univ, Coll Shipbldg Engn, Harbin 150001, Peoples R China.
[Demirbilek, Z.] Army Engn Res & Design Ctr, Coastal Hydraul Lab, Vicksburg, MS 39180 USA.
[Ertekin, R. C.] Univ Hawaii Manoa, Dept Ocean & Resources Engn, Honolulu, HI 96822 USA.
[Webster, W. C.] Univ Calif Berkeley, Dept Civil & Environm Engn, Berkeley, CA 94720 USA.
RP Zhao, BB (reprint author), Harbin Engn Univ, Coll Shipbldg Engn, Harbin 150001, Peoples R China.
EM zhaobinbinheu@hotmail.com
FU National Natural Science Foundation of China [51490671, 11572093];
International Science and Technology of Cooperation Project - Nation
Ministry of Science and Technology of China [2012DFA70420]; special Fund
for Basic Scientific Research of Central Colleges (Harbin Engineering
University); High-Tech Ship Research Projects - Ministry of Industry and
Information Technology (MIIT) of China
FX The first and third authors' (W.Y. Duan and B.B. Zhao) work is supported
by the National Natural Science Foundation of China (Nos. 51490671,
11572093), International Science and Technology of Cooperation Project
sponsored by Nation Ministry of Science and Technology of China (No.
2012DFA70420), the special Fund for Basic Scientific Research of Central
Colleges (Harbin Engineering University) and High-Tech Ship Research
Projects Sponsored by the Ministry of Industry and Information
Technology (MIIT) of China.
NR 28
TC 0
Z9 0
U1 3
U2 3
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0921-030X
EI 1573-0840
J9 NAT HAZARDS
JI Nat. Hazards
PD NOV
PY 2016
VL 84
SU 2
BP S567
EP S583
DI 10.1007/s11069-016-2464-0
PG 17
WC Geosciences, Multidisciplinary; Meteorology & Atmospheric Sciences;
Water Resources
SC Geology; Meteorology & Atmospheric Sciences; Water Resources
GA EB7VC
UT WOS:000387598000010
ER
PT J
AU Puffer, RC
Tou, K
Winkel, RE
Bydon, M
Currier, B
Freedman, BA
AF Puffer, Ross C.
Tou, Kevin
Winkel, Rose E.
Bydon, Mohamad
Currier, Bradford
Freedman, Brett A.
TI Liposomal bupivacaine incisional injection in single-level lumbar spine
surgery
SO SPINE JOURNAL
LA English
DT Article
DE Bupivacaine; Exparel; Liposomal; Local anesthesia; Lumbar; Spine;
Surgery
ID DEPOFOAM BUPIVACAINE; DOUBLE-BLIND; ANALGESIA; PAIN
AB BACKGROUND CONTEXT: Postsurgical pain control is important in spine surgery as it can lead to earlier mobilization, decreased length of stay, decreased side effects from narcotic medications, and improved patient satisfaction. Liposomal bupivacaine (LB) is an injectable formulation of bupivacaine, providing prolonged local anesthesia, up to 72 hours postinjection. Although, LB has been used with increasing frequency following other musculoskeletal procedures, specifically total joint replacements, its pre-emptive analgesic effect following lumbar microdiscectomy has hitherto not been reported. If administration of LB as a pre-emptive analgesic agent at the end of microdiscectomy resulted in reduced postoperative pain, then this could minimize adverse events related to narcotic pain medication use and improve acute clinical outcomes.
PURPOSE: The aim of the present study was to determine the comparative efficacy of infiltration of a standard dose and volume of LB in a comparative cohort analysis of single-level microdiscectomy procedures.
DESIGN: The present study made use of mixed prospective/retrospective observational cohort analysis.
PATIENT SAMPLE: Adult patients presenting with lumbar or sacral compressive disc disease treated with single-level microdiscectomy, at one institution utilizing a standard surgical technique.
OUTCOME MEASURES: Time spent on intravenous (IV) narcotics postoperatively (primary outcome), postoperative visual analog score (VAS), total morphine equivalent dose of narcotic pain medications, and 30-day emergency room visits for pain control were measured.
METHODS: Under an approved process improvement project, immediate outcome and process measures for a prospective cohort of 40 patients who received LB field blocks following single-level lumbar microdiscectomy were compared with a historical cohort of 40 patients who underwent the same surgical procedure but did not receive postsurgical infiltration of local anesthetic. All patients received a standard open surgical technique and postoperative convalescence protocol, which included overnight admission, oral narcotic pain medication as needed, scheduled IV ketorolac and IV narcotic pain medication for breakthrough.
RESULTS: Data from 80 subjects (67 males) operated on between January 2014 and 2015 were compared, including 40 cases, which occurred prior to using LB, and 40 cases after. There was no significant difference between mean age or body mass index (BMI) between groups. Patients who received LB infiltration spent significantly less time using IV narcotics in the postoperative period (LB patients 13.0 +/- 2.1 hours vs. non-LB patients 23.3 +/- 2.1 hours, p<.001). There was no significant difference noted between VAS at any point in the postoperative period, total injectable morphine equivalent doses, or 30-day emergency room visits for pain.
CONCLUSIONS: We found that patients who received LB field blocks required IV narcotic pain medication for a significantly decreased length of time (average delta=10.3 hours). Although this is a surrogate for earlier discharge, within the numbers studied, this did not translate into a significant difference in VAS scores or total morphine equivalents. It is uncertain, if the independent effect of LB may have been masked by the multimodal postoperative pain control protocol in use. Further study is required to best understand the potential benefit of pre-emptive analgesia in elective spine surgery. Its impact would likely be more significant in more invasive procedures. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Puffer, Ross C.; Bydon, Mohamad] Mayo Clin, Dept Neurosurg, 200 1st St SW, Rochester, MN 55905 USA.
[Tou, Kevin; Winkel, Rose E.] Us Army, Dept Orthoped, Landstuhl, Germany.
[Currier, Bradford; Freedman, Brett A.] Mayo Clin, Dept Orthoped, 200 1st St SW, Rochester, MN 55905 USA.
RP Freedman, BA (reprint author), Mayo Clin, Dept Orthoped Surg, 200 1st St SW, Rochester, MN 55905 USA.
EM freedman.brett@mayo.edu
NR 7
TC 0
Z9 0
U1 1
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1529-9430
EI 1878-1632
J9 SPINE J
JI Spine Journal
PD NOV
PY 2016
VL 16
IS 11
BP 1305
EP 1308
DI 10.1016/j.spinee.2016.06.013
PG 4
WC Clinical Neurology; Orthopedics
SC Neurosciences & Neurology; Orthopedics
GA EB6HU
UT WOS:000387483500018
PM 27349628
ER
PT J
AU Feasel, MG
Wohlfarth, A
Nilles, JM
Pang, SK
Kristovich, RL
Huestis, MA
AF Feasel, Michael G.
Wohlfarth, Ariane
Nilles, John M.
Pang, Shaokun
Kristovich, Robert L.
Huestis, Marilyn A.
TI Metabolism of Carfentanil, an Ultra-Potent Opioid, in Human Liver
Microsomes and Human Hepatocytes by High-Resolution Mass Spectrometry
SO AAPS JOURNAL
LA English
DT Article
DE carfentanil; metabolism; norcarfentanil; opioid
ID MAJOR METABOLITES; HUMAN URINE; FENTANYL; SUFENTANIL; ALFENTANIL;
REMIFENTANIL; RECEPTORS; REVEALS; BINDING; PLASMA
AB Carfentanil is an ultra-potent synthetic opioid. No human carfentanil metabolism data are available. Reportedly, Russian police forces used carfentanil and remifentanil to resolve a hostage situation in Moscow in 2002. This alleged use prompted interest in the pharmacology and toxicology of carfentanil in humans. Our study was conducted to identify human carfentanil metabolites and to assess carfentanil's metabolic clearance, which could contribute to its acute toxicity in humans. We used Simulations Plus's ADMET Predictor (TM) and Molecular Discovery's MetaSite (TM) to predict possible metabolite formation. Both programs gave similar results that were generally good but did not capture all metabolites seen in vitro. We incubated carfentanil with human hepatocytes for up to 1 h and analyzed samples on a Sciex 3200 QTRAP mass spectrometer to measure parent compound depletion and extrapolated that to represent intrinsic clearance. Pooled primary human hepatocytes were then incubated with carfentanil up to 6 h and analyzed for metabolite identification on a Sciex 5600+ TripleTOF (QTOF) high-resolution mass spectrometer. MS and MS/MS analyses elucidated the structures of the most abundant metabolites. Twelve metabolites were identified in total. N-Dealkylation and monohydroxylation of the piperidine ring were the dominant metabolic pathways. Two N-oxide metabolites and one glucuronide metabolite were observed. Surprisingly, ester hydrolysis was not a major metabolic pathway for carfentanil. While the human liver microsomal system demonstrated rapid clearance by CYP enzymes, the hepatocyte incubations showed much slower clearance, possibly providing some insight into the long duration of carfentanil's effects.
C1 [Feasel, Michael G.; Kristovich, Robert L.] US Army, Edgewood Chem Biol Ctr, Res Dev & Engn Command, 5183 Blackhawk Rd, Gunpowder, MD 21010 USA.
[Wohlfarth, Ariane; Huestis, Marilyn A.] NIDA, Chem & Drug Metab, Intramural Res Program, NIH, Baltimore, MD 21224 USA.
[Wohlfarth, Ariane] Natl Board Forens Med, Dept Forens Genet & Forens Toxicol, S-58758 Linkoping, Sweden.
[Wohlfarth, Ariane] Linkoping Univ, Div Drug Res, Dept Med Hlth Sci, S-58185 Linkoping, Sweden.
[Nilles, John M.] Excet Inc, Springfield, VA 22150 USA.
[Pang, Shaokun] SCIEX Ltd, Foster City, CA 94404 USA.
RP Feasel, MG (reprint author), US Army, Edgewood Chem Biol Ctr, Res Dev & Engn Command, 5183 Blackhawk Rd, Gunpowder, MD 21010 USA.
EM michael.g.feasel.civ@mail.mil
FU Defense Threat Reduction Agency (DTRA) [CB3281]
FX This work was funded by the Defense Threat Reduction Agency (DTRA) under
project number CB3281.
NR 33
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Z9 0
U1 5
U2 5
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1550-7416
J9 AAPS J
JI AAPS J.
PD NOV
PY 2016
VL 18
IS 6
BP 1489
EP 1499
DI 10.1208/s12248-016-9963-5
PG 11
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA EB7DU
UT WOS:000387547000015
PM 27495118
ER
PT J
AU Shamshina, JL
Barber, PS
Gurau, G
Griggs, CS
Rogers, RD
AF Shamshina, J. L.
Barber, P. S.
Gurau, G.
Griggs, C. S.
Rogers, R. D.
TI Pulping of Crustacean Waste Using Ionic Liquids: To Extract or Not To
Extract
SO ACS SUSTAINABLE CHEMISTRY & ENGINEERING
LA English
DT Article
DE Chitin.; Pulping Isolation; Ionic liquid; Sustainable
ID PHYSICOCHEMICAL PROPERTIES; MOLECULAR-WEIGHT; N-ACETYLATION; CHITIN;
CHITOSAN; SOLVENTS; BIOMASS; FIBERS; PRETREATMENT; CELLULOSE
AB Ionic liquids (ILs), such as hydroxylammonium acetate ([NH3OH][OAc]), can reactively demineralize and remove proteins from shrimp shells in an efficient one-pot pulping process, thus allowing the isolation of native chitin with >80% purity and a high degree of acetylation and crystallinity. Compared to a previously reported IL extraction using 1-ethy1-3-methylimidazolium acetate, [C(2)mim][OAc], these less expensive ILs can achieve comparable chitin yields and purity, at up to ten times the biomass loading, although potentially result in lower molecular weight (MW) chitin. Because the IL is not recovered or recycled, the cost can additionally be further reduced by the sequential addition of hydroxylamine and acetic acid (or vice versa) to conduct the pulping process in situ. Though each methodology results in a comparable yields and purity of chitin material, the varying production costs and process safety issues are still unknown. This work presents a step toward narrowing the choices for chitin isolation technologies that can lead to an economically and environmentally sustainable process replacing the current hazardous, energy consuming, and environmentally unsafe process.
C1 [Shamshina, J. L.; Barber, P. S.; Griggs, C. S.; Rogers, R. D.] Univ Alabama, Dept Chem, Box 870336, Tuscaloosa, AL 35487 USA.
[Shamshina, J. L.; Gurau, G.] 525 Solut Inc, 720 2nd St, Tuscaloosa, AL 35401 USA.
[Shamshina, J. L.; Gurau, G.; Rogers, R. D.] McGill Univ, Dept Chem, 801 Sherbrooke St West, Montreal, PQ H3A 0B8, Canada.
[Barber, P. S.] Williams Coll, Dept Chem, Williamstown, MA 01267 USA.
[Griggs, C. S.] US Army Engineer Res & Dev Ctr, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
RP Rogers, RD (reprint author), Univ Alabama, Dept Chem, Box 870336, Tuscaloosa, AL 35487 USA.; Rogers, RD (reprint author), McGill Univ, Dept Chem, 801 Sherbrooke St West, Montreal, PQ H3A 0B8, Canada.
EM Robin.Rogers@McGill.ca
FU U.S. Department of Energy (DOE) SBIR Office of Science [DE-SC0010152];
DOE Office of Nuclear Energy Nuclear Energy University Programs (DOE
NEUP Grant) [DE-NE0000672]; Canada Excellence Research Chairs Program
FX The authors thank the U.S. Department of Energy (DOE) SBIR Office of
Science (DE-SC0010152) and DOE Office of Nuclear Energy Nuclear Energy
University Programs (DOE NEUP Grant No. DE-NE0000672) for support. This
research was undertaken, in part, thanks to funding from the Canada
Excellence Research Chairs Program.
NR 37
TC 0
Z9 0
U1 8
U2 8
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 2168-0485
J9 ACS SUSTAIN CHEM ENG
JI ACS Sustain. Chem. Eng.
PD NOV
PY 2016
VL 4
IS 11
BP 6072
EP 6081
DI 10.1021/acssuschemeng.6b01434
PG 10
WC Chemistry, Multidisciplinary; GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY;
Engineering, Chemical
SC Chemistry; Science & Technology - Other Topics; Engineering
GA EB5PO
UT WOS:000387428700031
ER
PT J
AU Lieberman, HR
Karl, JP
McClung, JP
Williams, KW
Cable, S
AF Lieberman, Harris R.
Karl, J. Philip
McClung, James P.
Williams, Kelly W.
Cable, Sonya
TI Improved Mood State and Absence of Sex Differences in Response to the
Stress of Army Basic Combat Training
SO APPLIED PSYCHOLOGY-HEALTH AND WELL BEING
LA English
DT Article
DE anxiety; depression; gender; military; POMS; sex bias
ID PERFORMANCE; SOLDIERS; TRIAL
AB BackgroundIt is reported that women are more susceptible to stress than men but they have not been compared in stressful, real-world, team-centered, occupational/training environments. This study investigated effects of Army Basic Combat Training (BCT), a structured military training program, on the mood of young adult men and women.
MethodsUsing the Profile of Mood States (POMS) questionnaire, 169 soldiers (98 men and 71 women) were assessed prior to starting BCT and after each phase of training.
ResultsSignificant improvements were found in five of six subscales over the course of BCT. Men and women responded positively and similarly to BCT. POMS scores attributable to an interaction of time and each factor of sex, age group, education level, ethnicity, and race were not significantly different.
ConclusionsWhen studied in the same environment and exposed to the same stressors, men and women in this study responded similarly. The positive changes in mood in both sexes during BCT appear to result from the interaction of a structured physical and cognitive training program conducted in a team-oriented environment, and indicate that BCT enhances soldier mood similarly regardless of sex.
C1 [Lieberman, Harris R.; Karl, J. Philip; McClung, James P.] US Army Res Inst Environm Med, Mil Nutr Div, Natick, MA 01760 USA.
[Williams, Kelly W.] Oak Ridge Associated Univ, Oak Ridge, TN 37831 USA.
[Cable, Sonya] Womack Army Med Ctr, Ft Bragg, NC USA.
RP Lieberman, HR (reprint author), US Army Res Inst Environm Med, Mil Nutr Div, Natick, MA 01760 USA.
EM harris.r.lieberman.civ@mail.mil
NR 28
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Z9 0
U1 3
U2 3
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1758-0846
EI 1758-0854
J9 APPL PSYCHOL-HLTH WE
JI Appl. Psychol.-Health Well Being
PD NOV
PY 2016
VL 8
IS 3
BP 351
EP 363
DI 10.1111/aphw.12075
PG 13
WC Psychology, Applied
SC Psychology
GA EB1ON
UT WOS:000387122800004
PM 27401942
ER
PT J
AU Robb, ML
Ananworanich, J
AF Robb, Merlin L.
Ananworanich, Jintanat
TI Lessons from acute HIV infection
SO CURRENT OPINION IN HIV AND AIDS
LA English
DT Review
DE acute HIV infection; early antiretroviral therapy; HIV reservoir; HIV
vaccine; preventive HIV vaccine; therapeutic HIV vaccine
ID CD4(+) T-CELLS; SET-POINT; VIRAL LOAD; DISEASE PROGRESSION;
IDENTIFICATION; SEROCONVERSION; ACTIVATION; SYMPTOMS; DYNAMICS; SUBTYPE
AB Purpose of reviewUnderstanding the characteristics of transmission during acute HIV infection (AHI) may inform targets for vaccine-induced immune interdiction. Individuals treated in AHI with a small HIV reservoir size may be ideal candidates for therapeutic HIV vaccines aiming for HIV remission (i.e. viremic control after treatment interruption).Recent findingsThe AHI period is brief and peak viremia predicts a viral set point that occurs 4-5 weeks following infection. Robust HIV-specific CD8(+) T-cell responses lower viral set points. Phylogenetic analyses of founder viruses demonstrated unique bottleneck selections and specific genetic signatures to optimize for high-fitness variants and successful transmission events. HIV clades, route of transmission and the presence of minor variants may affect vaccine protection. Antiretroviral treatment in AHI results in smaller HIV reservoir size, better CD4(+) T-cell recovery and fewer virus escapes.SummaryThe knowledge of untreated and treated AHI informs the development of vaccines, in that preventive vaccines will require broad coverage for multiple clades and antigenic variants associated with unique bottleneck selections. Vaccines that help the host to control viremia could minimize onward transmission. Therapeutic HIV vaccines aimed at HIV remission should be studied in early-treated individuals who have few or no viral escape mutants and a more preserved immune system.
C1 [Robb, Merlin L.; Ananworanich, Jintanat] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA.
[Robb, Merlin L.; Ananworanich, Jintanat] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA.
RP Robb, ML (reprint author), Walter Reed Army Inst Res, US Mil HIV Res Program, 6720A Rockledge Dr,Suite 400, Bethesda, MD 20817 USA.
EM mrobb@hivresearch.org
FU Henry M. Jackson Foundation for the Advancement of Military Medicine,
Inc. [W81XWH-07-2-0067, W81XWH-11-2-0174]; United States Department of
the Army; NIAID [R01AI114236]
FX The given work was supported by cooperative agreements (W81XWH-07-2-0067
and W81XWH-11-2-0174) between The Henry M. Jackson Foundation for the
Advancement of Military Medicine, Inc., and the United States Department
of the Army. J.A. was partially funded by NIAID R01AI114236. We thank Ms
Oratai Butterworth for her assistance in preparing this manuscript.
Disclaimer: The views expressed are those of the authors and should not
be construed to represent the positions of the US Army or the Department
of Defense.
NR 43
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Z9 0
U1 9
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1746-630X
EI 1746-6318
J9 CURR OPIN HIV AIDS
JI Curr. Opin. HIV AIDS
PD NOV
PY 2016
VL 11
IS 6
BP 555
EP 560
DI 10.1097/COH.0000000000000316
PG 6
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA EA1JP
UT WOS:000386348700003
PM 27716734
ER
PT J
AU Rao, M
Alving, CR
AF Rao, Mangala
Alving, Carl R.
TI Adjuvants for HIV vaccines
SO CURRENT OPINION IN HIV AND AIDS
LA English
DT Review
DE adjuvant; Army Liposome Formulation; HIV; liposomes; monophosphoryl
lipid A; vaccine
ID T-CELL RESPONSES; MONOPHOSPHORYL-LIPID-A; S/AS01 MALARIA VACCINE;
IMMUNE-RESPONSES; ENVELOPE PROTEIN; DOUBLE-BLIND; SIVMAC251 ACQUISITION;
RHESUS-MONKEYS; EFFICACY TRIAL; DNA VACCINES
AB Purpose of reviewAdvances in the understanding of the structural biology of HIV-1 proteins, and in the vulnerabilities of HIV-1 at various points in the infectious process have led to innovative approaches for vaccine constructs for clinical trials. Lessons from the successful Retrovirology study 144 (RV144) phase III Thai trial have revealed the need for novel and more potent adjuvant formulations. Fortunately, the vaccine adjuvant field is experiencing an emergence of innovative new adjuvants and strategies that may lead to improved formulations.Recent findingsThe review highlights the status of currently used and available new adjuvant formulations for HIV antigens. Adjuvants used in preclinical or in human clinical trials using HIV-1 protein antigens will be discussed along with adjuvant improvements for vectors and DNA immunization.SummaryThe HIV-1 immunogen and the design of the adjuvant formulations are both equally important for the development of an effective HIV vaccine. Adjuvants work by numerous different mechanisms, many of which are quite complex and often not well comprehended. Understanding the interplay of innate and adaptive immune responses that can be harnessed by adjuvant formulations would aid in the rational design of a well tolerated and effective vaccine formulation that can block HIV at the site of transmission.
C1 [Rao, Mangala; Alving, Carl R.] Walter Reed Army Inst Res, US Mil HIV Res Program, Lab Adjuvant & Antigen Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
RP Rao, M (reprint author), Walter Reed Army Inst Res, US Mil HIV Res Program, Lab Adjuvant & Antigen Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM calving@hivresearch.org
FU Henry M. Jackson Foundation for the Advancement of Military Medicine
[W81XWH-07-2-067]; US Army Medical Research and Materiel Command (MRMC)
FX The work was supported through a Cooperative Agreement Award
(W81XWH-07-2-067) between Henry M. Jackson Foundation for the
Advancement of Military Medicine and the US Army Medical Research and
Materiel Command (MRMC). The views expressed in this article are those
of the authors and do not necessarily reflect the official policy of the
Department of the Army, Department of Defense, or the US Government.
NR 62
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U1 4
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1746-630X
EI 1746-6318
J9 CURR OPIN HIV AIDS
JI Curr. Opin. HIV AIDS
PD NOV
PY 2016
VL 11
IS 6
BP 585
EP 592
DI 10.1097/COH.0000000000000315
PG 8
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA EA1JP
UT WOS:000386348700007
PM 27607594
ER
PT J
AU Excler, JL
Michael, NL
AF Excler, Jean-Louis
Michael, Nelson L.
TI Lessons from HIV-1 vaccine efficacy trials
SO CURRENT OPINION IN HIV AND AIDS
LA English
DT Editorial Material
DE clinical trials; correlates of risk; efficacy; HIV; RV144; vaccine
ID T-CELL VACCINE; NEUTRALIZING ANTIBODY-RESPONSE;
HUMAN-IMMUNODEFICIENCY-VIRUS; HIGHLY PATHOGENIC SIV; RHESUS-MONKEYS;
GAG/POL/NEF VACCINE; DOUBLE-BLIND; PREEXPOSURE PROPHYLAXIS; SIVMAC251
ACQUISITION; CONSERVED REGIONS
AB Purpose of reviewOnly four HIV-1 vaccine concepts have been tested in six efficacy trials with no product licensed to date. Several scientific and programmatic lessons can be learned from these studies generating new hypotheses and guiding future steps.Recent findingsRV144 [ALVAC-HIV (canarypox vector) and AIDSVAX B/E (bivalent gp120 HIV-1 subtype B and CRF01_AE)] remains the only efficacy trial that demonstrated a modest vaccine efficacy, which led to the identification of immune correlates of risk. Progress on subtype-specific, ALVAC (canarypox vector) and gp120 vaccine prime-boost approaches has been slow, but we are finally close to the launch of an efficacy study in Africa in 2016. The quest of a globally effective HIV-1 vaccine has led to the development of new approaches. Efficacy studies of combinations of Adenovirus type 26 (Ad26)/Modified Vaccinia Ankara (MVA)/gp140 vaccines with mosaic designs will enter efficacy studies mid-2017 and cytomegalovirus (CMV)-vectored vaccines begin Phase I studies at the same time. Future HIV-1 vaccine efficacy trials face practical challenges as effective nonvaccine prevention programs are projected to decrease HIV-1 incidence.SummaryAn HIV-1 vaccine is urgently needed. Increased industry involvement, mobilization of resources, expansion of a robust pipeline of new concepts, and robust preclinical challenge studies will be essential to accelerate efficacy testing of next generation HIV-1 vaccine candidates.
C1 [Excler, Jean-Louis] Henry M Jackson Fdn, US Mil HIV Res Program, Bethesda, MD USA.
[Excler, Jean-Louis] SNU Res Pk, Intt Vaccine Inst, 1 Gwanak Ro, Seoul 08826, South Korea.
[Michael, Nelson L.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA.
RP Excler, JL (reprint author), SNU Res Pk, Intt Vaccine Inst, 1 Gwanak Ro, Seoul 08826, South Korea.
EM jexcler@hivresearch.org
NR 87
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U1 4
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1746-630X
EI 1746-6318
J9 CURR OPIN HIV AIDS
JI Curr. Opin. HIV AIDS
PD NOV
PY 2016
VL 11
IS 6
BP 607
EP 613
DI 10.1097/COH.0000000000000312
PG 7
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA EA1JP
UT WOS:000386348700010
PM 27537673
ER
PT J
AU Sheean, AJ
Tennent, DJ
Owens, JG
Wilken, JM
Hsu, JR
Stinner, DJ
AF Sheean, Andrew J.
Tennent, David J.
Owens, Johnny G.
Wilken, Jason M.
Hsu, Joseph R.
Stinner, Daniel J.
CA Skeletal Trauma Res Consortium
TI Effect of Custom Orthosis and Rehabilitation Program on Outcomes
Following Ankle and Subtalar Fusions
SO FOOT & ANKLE INTERNATIONAL
LA English
DT Article
DE hindfoot fusion; outcome studies; arthritis; rehabilitation
ID OPERATION ENDURING FREEDOM; LOWER-EXTREMITY TRAUMA; IRAQI FREEDOM; LIMB
SALVAGE; RETURN; PERFORMANCE; DUTY; DISABILITY; AMPUTATION; WOUNDS
AB Background: Fractures of the distal tibia, ankle, and foot sustained through a high-energy mechanism can be extremely debilitating, and ankle and/or subtalar fusion may be indicated if the limb is deemed salvageable. Functional outcomes among this population are often poor. The purposes of this study were to evaluate the effect of an advanced rehabilitation program combined with the use of a custom ankle-foot orthosis for patients with ankle or subtalar fusion on selected physical performance measures and patient-derived outcome measures and to determine if the response to treatment was predicated upon the type of fusion.
Methods: We conducted a prospective, longitudinal, observational, cohort study composed of 23 active duty Service Members treated for lower extremity trauma. Patients were separated into 2 groups: group 1 was composed of 12 patients who underwent isolated ankle fusion or ankle fusion combined with ipsilateral subtalar fusion, group 2 was composed of 11 patients who underwent subtalar fusion only. Patient-reported outcome (PRO) measures and physical performance measures were recorded at baseline and at the conclusion of the rehabilitation program.
Results: Significant improvements in both groups were seen in each of the 4 physical performance measures. Only group 2 showed significant improvements in all domains of the Veteran's Rand 12-Item Health Survey (VR-12) and Short Musculoskeletal Function Assessment (SMFA) at all points during the course of rehabilitation.
Conclusion: Among a subset of patients treated for severe lower extremity trauma with ankle and/or subtalar fusion, an integrated orthotic and rehabilitation initiative improved physical performance and PRO measures over an 8-week course.
Level of Evidence: Level III, prospective comparative series
C1 [Sheean, Andrew J.; Tennent, David J.; Owens, Johnny G.; Wilken, Jason M.] San Antonio Mil Med Ctr, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
[Hsu, Joseph R.] Carolinas Med Ctr, Charlotte, NC 28203 USA.
[Stinner, Daniel J.] US Army Inst Surg Res, Ft Sam Houston, TX USA.
RP Sheean, AJ (reprint author), San Antonio Mil Med Ctr, 3851 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
EM ajsheean@gmail.com
FU Combat Casualty Care Research Program
FX The author(s) disclosed receipt of the following financial support for
the research, authorship, and/or publication of this article: Joseph R.
Hsu, MD, reports grants from Combat Casualty Care Research Program,
during the conduct of the study.
NR 19
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U1 0
U2 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1071-1007
EI 1944-7876
J9 FOOT ANKLE INT
JI Foot Ankle Int.
PD NOV
PY 2016
VL 37
IS 11
BP 1205
EP 1210
DI 10.1177/1071100716660821
PG 6
WC Orthopedics
SC Orthopedics
GA EB4HK
UT WOS:000387331300010
PM 27521355
ER
PT J
AU Jackson, KL
Devine, JG
AF Jackson, Keith L., II
Devine, John G.
TI The Effects of Smoking and Smoking Cessation on Spine Surgery: A
Systematic Review of the Literature
SO GLOBAL SPINE JOURNAL
LA English
DT Review
DE tobacco; smoking; lumbar spine; cervical spine
ID ANTERIOR CERVICAL ARTHRODESIS; SURGICAL SITE INFECTIONS; RISK-FACTORS;
CIGARETTE-SMOKING; HEALTH-BENEFITS; POSTOPERATIVE COMPLICATIONS;
POSTEROLATERAL FUSION; NICOTINE REPLACEMENT; IDENTICAL-TWINS; LUMBAR
SPINE
AB Study DesignLiterature review.
ObjectiveThe aim of this literature review was to detail the effects of smoking in spine surgery and examine whether perioperative smoking cessation could mitigate these risks.
MethodsA review of the relevant literature examining the effects of smoking and cessation on surgery was conducted using PubMed, Google Scholar, and Cochrane databases.
ResultsCurrent smokers are significantly more likely to experience pseudarthrosis and postoperative infection and to report lower clinical outcomes after surgery in both the cervical and lumbar spines. Smoking cessation can reduce the risks of these complications depending on both the duration and timing of tobacco abstinence.
ConclusionSmoking negatively affects both the objective and subjective outcomes of surgery in the lumbar and cervical spine. Current literature supports smoking cessation as an effective tool in potentially mitigating these unwanted outcomes. Future investigations in this field should be directed toward developing a better understanding of the complex relationship between smoking and poorer outcomes in spine surgery as well as developing more efficacious cessation strategies.
C1 [Jackson, Keith L., II] Womack Army Med Ctr, Dept Orthopaed & Rehabil, 2817 Reilly Rd, Ft Bragg, NC 28310 USA.
[Devine, John G.] Georgia Regents Univ, Dept Orthopaed Surg, Augusta, GA USA.
RP Jackson, KL (reprint author), Womack Army Med Ctr, Dept Orthopaed & Rehabil, 2817 Reilly Rd, Ft Bragg, NC 28310 USA.
EM Lynn.Jackson9@gmail.com
NR 68
TC 0
Z9 0
U1 4
U2 4
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 2192-5682
EI 2192-5690
J9 GLOB SPINE J
JI Glob. Spine J.
PD NOV
PY 2016
VL 6
IS 7
BP 695
EP 701
DI 10.1055/s-0036-1571285
PG 7
WC Orthopedics
SC Orthopedics
GA EA8YD
UT WOS:000386925100011
PM 27781190
ER
PT J
AU Kim, E
Dembsey, N
Godfrey, T
Roylance, M
AF Kim, Esther
Dembsey, Nicholas
Godfrey, Thomas
Roylance, Margaret
TI Numerical modeling of fabric vertical flame testing: Textile samples
SO JOURNAL OF FIRE SCIENCES
LA English
DT Article
DE Vertical flame test; computational fluid dynamic modeling; textiles;
fire performance
ID EXOTHERMIC DECOMPOSITION; THERMOGRAVIMETRIC DATA; KINETIC-ANALYSIS;
PREDICTION; SIZES
AB The advantage of utilizing modeling to study fire performance of textiles is the ability to conduct detailed studies of the effect of fabric characteristics on flame spread. First, two textile materials are chosen for modeling that exhibit two limit cases: complete flame spread (nylon 6,6/cotton fiber fabric) and self-extinguish (flame retardant rayon/nylon 6,6/para-aramid fiber fabric) in the standard vertical flame test (ASTM D6413). Parameter estimation for unknown model parameters is performed for these samples followed by a sensitivity analysis. Then a new sample is modeledflame retardant cotton fiber fabric, flame retardant cotton. This modeling exercise shows that computational fluid dynamics modeling is capable of capturing the fire characteristics of different fabric samples in the vertical flame test only when the parameters are carefully estimated considering the modeling assumptions and approaches. Additionally, several areas for further investigation are proposed to improve simulation capability when conducting vertical flame test modeling with textile samples.
C1 [Kim, Esther; Godfrey, Thomas; Roylance, Margaret] US Army Natick Soldier Res, Ctr Dev & Engn, Natick, MA USA.
[Kim, Esther; Dembsey, Nicholas] Worcester Polytech Inst, Dept Fire Protect Engn, Worcester, MA 01609 USA.
RP Kim, E (reprint author), Gateway Pk 2,50 Prescott St, Worcester, MA 01605 USA.
EM ntcno3@hotmail.com
FU Postgraduate Research Participation Program at the U.S. Army Natick
Soldier Research, Development and Engineering Center (NSRDEC)
FX This research was supported, in part, by an appointment to the
Postgraduate Research Participation Program at the U.S. Army Natick
Soldier Research, Development and Engineering Center (NSRDEC)
administered by the Oak Ridge Institute for Science and Education
through an interagency agreement between the U.S. Department of Energy
and NSRDEC.
NR 25
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Z9 0
U1 9
U2 9
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0734-9041
EI 1530-8049
J9 J FIRE SCI
JI J. Fire Sci.
PD NOV
PY 2016
VL 34
IS 6
BP 468
EP 489
DI 10.1177/0734904116667634
PG 22
WC Engineering, Multidisciplinary; Materials Science, Multidisciplinary
SC Engineering; Materials Science
GA EB4CL
UT WOS:000387316700002
ER
PT J
AU Hennigar, SR
McClung, JP
AF Hennigar, Stephen R.
McClung, James P.
TI Hepcidin Attenuates Zinc Efflux in Caco-2 Cells
SO JOURNAL OF NUTRITION
LA English
DT Article
DE zinc transporter; iron; inflammation; enterocyte; mineral absorption
ID IRON TRANSPORTER EXPRESSION; DIETARY ZINC; ZIP14 SLC39A14; INFLAMMATION;
FERROPORTIN; GENE; UBIQUITINATION; HEPATOCYTES; CONTRIBUTES; METABOLISM
AB Background: Hepcidin mediates the hypoferremia of inflammation by inhibiting iron transfer into circulation; however, a regulator for the hypozincemia observed in individuals with acute and chronic inflammatory and infectious diseases is not known.
Objective: The objective of this study was to determine the effects of hepcidin on zinc transport in intestinal epithelial cells.
Methods: Differentiated human intestinal Caco-2 cells were untreated or treated with 1 M hepcidin for 3-24 h. Zinc transport was assessed in cells seeded on Transwell inserts. Media from the apical and basolateral chambers were collected, and zinc concentrations were determined using Zn-67. Labile zinc pools were imaged and quantified in cells loaded with FluoZin-3-AM and expression of metallothionein and the zinc transporters zrt-/irt-like protein (ZIP)4 (SLC39A4), ZI P5 (SLC39A5), ZI P14 (SLC39A14), and zinc transporter 1 (ZnT1) (SLC30A1) was determined. Cells were transfected with SLC40A1-or SLC30A1-specific small interfering RNA to knock down ferroportin and ZnT1 protein, respectively. Cell surface proteins were isolated by cell surface biotinylation and lysosomal and proteasomal degradation was inhibited by treating cells with chloroquine or MG132, respectively.
Results: Hepcidin attenuated zinc transport, as cells treated with hepcidin exported 26% less Zn-67 (P < 0.05) into the basolateral chamber and retained 27% more cellular Zn-67 (P < 0.05) than did control cells. Labile zinc decreased, and the mRNA abundance of metallothionein increased by similar to 50% in hepcidin-treated cells compared with control cells (P < 0.05). Hepcidin reduced ZnT1 protein by 75% (P< 0.05) compared with control cells. Hepcidin-mediated reductions in zinc export remained in ferroportin knockdown cells compared with untreated controls (P < 0.05), whereas knockdown of ZnT1 inhibited this effect (P >= 0.05). Hepcidin significantly reduced biotinylated cell surface ZnT1 compared with control cells (P < 0.05); chloroquine inhibited hepcidin-mediated degradation of ZnT1 (P 0.05), whereas MG132 had no effect (P< 0.05).
Conclusions: Hepcidin reduces intestinal zinc export by post-translationally downregulating ZnT1 through a lysosomal-mediated degradation pathway, indicating that hepcidin may contribute to the hypozincemia of inflammation and infection.
C1 [Hennigar, Stephen R.; McClung, James P.] US Army, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA.
RP McClung, JP (reprint author), US Army, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA.
EM james.p.mcclung8.civ@mail.mil
FU US Army Medical Research and Material Command
FX Supported in part by the US Army Medical Research and Material Command
and appointment to the US Army Research Institute of Environmental
Medicine administered by the Oak Ridge Institute for Science and
Education (to SRH) through an interagency agreement between the US
Department of Energy and the US Army Medical Research and Material
Command.
NR 36
TC 0
Z9 0
U1 5
U2 5
PU AMER SOC NUTRITION-ASN
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-3166
EI 1541-6100
J9 J NUTR
JI J. Nutr.
PD NOV
PY 2016
VL 146
IS 11
BP 2167
EP 2173
DI 10.3945/jn.116.237081
PG 7
WC Nutrition & Dietetics
SC Nutrition & Dietetics
GA EB3XD
UT WOS:000387301500001
PM 27655758
ER
PT J
AU Kocifaj, M
Kundracik, F
Videen, G
AF Kocifaj, Miroslav
Kundracik, Frantigek
Videen, Gorden
TI Optical characterization of electrically charged particles using
discrete dipole approximation
SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER
LA English
DT Article
DE Electromagnetic scattering; Charged particles; Surface current density;
Discrete dipole approximation
ID DIRECTIONAL SCATTERING; ELECTROMAGNETIC-WAVES; NANOPARTICLES;
ABSORPTION; RESONANCES; NANODISKS; LIGHT
AB The dependence of the electric potential on the absorption and scattering of light by small particles has emerged as an interesting research topic, as the unexpected amplified optical signatures of a system of electrically charged particles were satisfactory predicted recently for homogeneous, uniformly charged spheres. However, natural particles are rarely of spherical shape. A comprehensive understanding of how arbitrarily shaped, charged particles interact with electromagnetic radiation has been missing. The approach we present here attempts to fill this gap by introducing a numerical formulation of the electromagnetic scattering problem for these particles. The first results from the inter comparison of numerical and analytical solutions for a pseudosphere show that the resonance features found are largely consistent, except for the magnitude and width of the peak amplitude, which may be due to inherent differences in the approaches used. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Kocifaj, Miroslav] Slovak Acad Sci, ICA, Dubravska Rd 9, Bratislava 84503, Slovakia.
[Kocifaj, Miroslav; Kundracik, Frantigek] Comenius Univ, Fac Math Phys & Informat, Bratislava 84248, Slovakia.
[Videen, Gorden] INTA, Ctra Ajalvir Km 4, Madrid 28850, Spain.
[Videen, Gorden] US Army, Res Lab, AMSRD ARL CI ES, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
RP Kocifaj, M (reprint author), Slovak Acad Sci, ICA, Dubravska Rd 9, Bratislava 84503, Slovakia.
EM kocifaj@savba.sk; kundracik@fmph.uniba.sk; gorden.w.videen.civ@mail.mil
FU US Army International Technology Center [W911NF-14-1-0601, RD
1695-PH-01]; Slovak National Grant Agency VEGA [2/0016/16]
FX This work was supported by the US Army International Technology Center
under the contract no. W911NF-14-1-0601 (R&D 1695-PH-01). Computational
work was supported by the Slovak National Grant Agency VEGA (grant no.
2/0016/16). The authors gratefully acknowledge the discussion of Prof.
Bruce Draine.
NR 20
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U1 1
U2 1
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-4073
EI 1879-1352
J9 J QUANT SPECTROSC RA
JI J. Quant. Spectrosc. Radiat. Transf.
PD NOV
PY 2016
VL 184
BP 161
EP 166
DI 10.1016/j.jqsrt.2016.07.010
PG 6
WC Optics; Spectroscopy
SC Optics; Spectroscopy
GA EA9RL
UT WOS:000386982300016
ER
PT J
AU Marlin, B
Sohn, H
AF Marlin, B.
Sohn, H.
TI Using DEA in conjunction with designs of experiments: an approach to
assess simulated futures in the Afghan educational system
SO JOURNAL OF SIMULATION
LA English
DT Article
DE discrete event simulation; data envelopment analysis; nearly orthogonal
Latin hypercubes; design of experiment; education simulation; developing
countries
ID DATA ENVELOPMENT ANALYSIS; EFFICIENCY; VERIFICATION; VALIDATION; SCHOOLS
AB This research presents an assessment of the simulated futures of the Afghan educational system. We use a hybrid analytical process combining simulation, design of experiments, and data envelopment analysis (DEA) that is capable of studying the dynamic behaviour of the Afghan educational system. By using the process, we are able to determine the critical relationships, potential futures, and unforeseen consequences of potential policies regarding primary and secondary education in Afghanistan. This research also provides insight into the use of DEA when applied to a large-scale discrete event social simulation.
C1 [Marlin, B.] US Army, TRADOC Anal Ctr, Martin Luther King Dr,Bldg 1400, White Sands Missile Range, NM 88002 USA.
[Sohn, H.] New Mexico State Univ, Las Cruces, NM 88003 USA.
RP Marlin, B (reprint author), US Army, TRADOC Anal Ctr, Martin Luther King Dr,Bldg 1400, White Sands Missile Range, NM 88002 USA.
RI Sohn, Hansuk/B-9808-2013
OI Sohn, Hansuk/0000-0002-8126-730X
FU US Army; Afghan Ministry of Education; NATO Training Mission Afghanistan
FX This research was partly funded by the US Army. The support of the
Afghan Ministry of Education and NATO Training Mission Afghanistan is
gratefully acknowledged. The authors would also like to thank USAID
Afghanistan and the US Army analysts for many fruitful discussions and
helpful comments during the course of this research.
NR 35
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Z9 0
U1 2
U2 2
PU PALGRAVE MACMILLAN LTD
PI BASINGSTOKE
PA BRUNEL RD BLDG, HOUNDMILLS, BASINGSTOKE RG21 6XS, HANTS, ENGLAND
SN 1747-7778
EI 1747-7786
J9 J SIMUL
JI J. Simul.
PD NOV
PY 2016
VL 10
IS 4
BP 272
EP 282
DI 10.1057/jos.2015.14
PG 11
WC Computer Science, Interdisciplinary Applications; Operations Research &
Management Science
SC Computer Science; Operations Research & Management Science
GA EB2NU
UT WOS:000387199900004
ER
PT J
AU Davis, MR
Easter, RL
Carlock, JM
Weiss, LW
Longo, EA
Smith, LM
Dawes, JJ
Schilling, BK
AF Davis, Matthew R.
Easter, Richard L.
Carlock, Jonathan M.
Weiss, Lawrence W.
Longo, Elizabeth A.
Smith, Lisa M.
Dawes, J. Jay
Schilling, Brian K.
TI SELF-REPORTED PHYSICAL TASKS AND EXERCISE TRAINING IN SPECIAL WEAPONS
AND TACTICS (SWAT) TEAMS
SO JOURNAL OF STRENGTH AND CONDITIONING RESEARCH
LA English
DT Article
DE survey; tactical strength and conditioning; job performance
ID CORRECTIONAL OFFICER APPLICANTS; CONDITIONING PRACTICES;
BODY-COMPOSITION; LEAGUE STRENGTH; POLICE OFFICERS; FITNESS TEST;
COACHES; PERFORMANCE; STANDARDS
AB Little research has been done examining the most physically demanding tasks a SWAT officer may perform in the line of duty. Our objective was to analyze the rankings of tasks by SWAT officers based on frequency, difficulty, and importance and assess if training is addressing traits needed for successful task completion. A survey was designed using Qualtrics (Qualtrics Labs Inc). The survey had a demographics section, performance section, and training section. Officers were contacted by phone or e-mail and asked about interest in participating. Officers who agreed were sent the survey. Our results found a strong correlation between frequency of task and importance (r = 0.69, p = 0.001), and a moderate correlation was found between task difficulty and importance (r = 0.37, p = 0.005). Task rankings were averaged across the 3 domains to assess "overall" importance, and the top 3 tasks were assessed for necessary traits for successful performance. Power and strength were determined to be the most important traits for successful performance. Officers ranked the top 2 focuses of their training program in the training section as stamina/muscular endurance and cardiovascular/respiratory endurance. Training programs for SWAT officers should be developed to improve performance of the tasks with the highest "overall" importance. Therefore, a training program should emphasize strength and power improvements while not neglecting other measures of fitness.
C1 [Davis, Matthew R.; Easter, Richard L.; Weiss, Lawrence W.; Longo, Elizabeth A.; Smith, Lisa M.; Schilling, Brian K.] Univ Memphis, Memphis, TN 38152 USA.
[Carlock, Jonathan M.] US Army Special Operat Command, Ft Bragg, NC USA.
[Dawes, J. Jay] Univ Colorado, Colorado Springs, CO 80907 USA.
RP Schilling, BK (reprint author), Univ Memphis, Memphis, TN 38152 USA.
EM bschllng@memphis.edu
NR 30
TC 0
Z9 0
U1 1
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1064-8011
EI 1533-4287
J9 J STRENGTH COND RES
JI J. Strength Cond. Res.
PD NOV
PY 2016
VL 30
IS 11
BP 3242
EP 3248
DI 10.1519/JSC.0000000000001411
PG 7
WC Sport Sciences
SC Sport Sciences
GA EB1ZL
UT WOS:000387155600034
PM 26950355
ER
PT J
AU Kardouni, JR
Mckinnon, CJ
Seitz, AL
AF Kardouni, Joseph R.
Mckinnon, Craig J.
Seitz, Amee L.
TI Incidence of Shoulder Dislocations and the Rate of Recurrent Instability
in Soldiers
SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
LA English
DT Article
DE GLENOHUMERAL DISLOCATION; EPIDEMIOLOGY; MILITARY; TACTICAL ATHLETE
ID ANTERIOR DISLOCATION; UNITED-STATES; RISK-FACTORS; PROGNOSIS; INJURY;
ADULTS
AB Purpose Shoulder dislocations present a potentially debilitating injury for soldiers and other groups of physically active adults. The purpose of this study was to determine the 10-yr incidence rate of shoulder dislocations in soldiers, the percentage with recurrent instability, and risk factors for these injuries.
Methods This retrospective cohort study used medical encounter data from U.S. Army soldiers to calculate the 10-yr incidence rate for shoulder dislocations and the percentage of chronic or recurrent injuries >3 months and 2 yr after the initial diagnosis. A Cox proportional hazards model was constructed using demographic variables (age, race, education level, marital status, and sex) to determine incidence rate ratios for risk factors related to shoulder dislocation. Logistic regression was used to calculate odds ratio for risk factors for recurrent injury, including concurrent diagnoses (brachial plexus or peripheral nerve injuries and fractures of the scapula or proximal humerus).
Results There were 15,426 incident shoulder dislocations, with a 10-yr incidence rate of 3.13 per 1000 person-year. Soldiers 40 yr old showed greater risk for injury compared with those older than 40 yr. The incidence rate ratio for males compared with females was 1.64, 95% confidence interval = 1.55-1.74. Recurrent injury occurred in 28.7% of cases. Concurrent axillary nerve injury (odds ratio = 3.64, 95% confidence interval = 1.56-8.46) and age 35 yr were associated with greater risk of recurrence.
Conclusion Within the active duty U.S. Army, men and younger individuals showed greater risk for shoulder dislocations. Over one-quarter of incident cases became recurrent. Axillary nerve injuries and younger age increased the odds of recurrent injury.
C1 [Kardouni, Joseph R.; Mckinnon, Craig J.] US Army Res Inst Environm Med, Mil Performance Div, 10 Gen Greene Ave,Bldg 42, Natick, MA 01760 USA.
[Seitz, Amee L.] Northwestern Univ, Feinberg Sch Med, Dept Phys Therapy & Human Movement Sci, Chicago, IL 60611 USA.
RP Kardouni, JR (reprint author), US Army Res Inst Environm Med, Mil Performance Div, 10 Gen Greene Ave,Bldg 42, Natick, MA 01760 USA.
EM joseph.r.kardouni.mil@mail.mil
NR 23
TC 0
Z9 0
U1 2
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0195-9131
EI 1530-0315
J9 MED SCI SPORT EXER
JI Med. Sci. Sports Exerc.
PD NOV
PY 2016
VL 48
IS 11
BP 2150
EP 2156
DI 10.1249/MSS.0000000000001011
PG 7
WC Sport Sciences
SC Sport Sciences
GA EA4OU
UT WOS:000386593200010
PM 27327025
ER
PT J
AU Rodriguez-Hart, C
Liu, HJ
Nowak, RG
Orazulike, I
Zorowitz, S
Crowell, TA
Baral, SD
Blattner, W
Charurat, M
AF Rodriguez-Hart, Cristina
Liu, Hongjie
Nowak, Rebecca G.
Orazulike, Ifeanyi
Zorowitz, Sam
Crowell, Trevor A.
Baral, Stefan D.
Blattner, William
Charurat, Man
TI Serosorting and Sexual Risk for HIV Infection at the Ego-Alter Dyadic
Level: An Egocentric Sexual Network Study Among MSM in Nigeria
SO AIDS AND BEHAVIOR
LA English
DT Article
DE HIV serosorting; men who have sex with men; sexual behavior; egocentric
network; Nigeria
ID UNPROTECTED ANAL INTERCOURSE; REDUCTION PRACTICES; MEN; PREVALENCE;
PARTNERS; GAY; INDIVIDUALS; SWITZERLAND; EJACULATION; PREVENTION
AB The objective of this egocentric network study was to investigate engagement in serosorting by HIV status and risk for HIV between seroconcordant and serodiscordant ego-alter dyads. Respondent-driving sampling was used to recruit 433 Nigerian men who have sex with men (MSM) from 2013 to 2014. Participant (ego) characteristics and that of five sex partners (alters) were collected. Seroconcordancy was assessed at the ego level and for each dyad. Among 433 egos, 18 % were seroconcordant with all partners. Among 880 dyads where participants knew their HIV status, 226 (25.7 %) were seroconcordant, with 11.7 % of HIV positive dyads seroconcordant and 37.0 % of HIV negative dyads seroconcordant. Seroconcordant dyads reported fewer casual sex partners, less partner concurrency, and partners who had ever injected drugs, but condom use did not differ significantly. Serosorting may be a viable risk reduction strategy among Nigerian MSM, but awareness of and communication about HIV status should be increased. Future studies should assess serosorting on a partner-by-partner basis.
C1 [Rodriguez-Hart, Cristina; Nowak, Rebecca G.; Blattner, William; Charurat, Man] Univ Maryland, Sch Med, Inst Human Virol, 725 W Lombard St, Baltimore, MD 21201 USA.
[Rodriguez-Hart, Cristina; Baral, Stefan D.] Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD 21205 USA.
[Liu, Hongjie] Univ Maryland, Sch Publ Hlth, College Pk, MD 20742 USA.
[Orazulike, Ifeanyi] Int Ctr Advocacy & Rights Hlth, Abuja, Nigeria.
[Zorowitz, Sam] Massachusetts Gen Hosp, Dept Psychiat, Div Neurotherapeut, Boston, MA 02114 USA.
[Zorowitz, Sam] Harvard Med Sch, Boston, MA USA.
[Crowell, Trevor A.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA.
[Crowell, Trevor A.] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA.
RP Rodriguez-Hart, C (reprint author), Univ Maryland, Sch Med, Inst Human Virol, 725 W Lombard St, Baltimore, MD 21201 USA.; Rodriguez-Hart, C (reprint author), Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD 21205 USA.
EM crodri32@jhu.edu
FU NIAID NIH HHS [R01 AI120913]; NIMH NIH HHS [R01 MH099001]
NR 34
TC 1
Z9 1
U1 4
U2 4
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1090-7165
EI 1573-3254
J9 AIDS BEHAV
JI AIDS Behav.
PD NOV
PY 2016
VL 20
IS 11
BP 2762
EP 2771
DI 10.1007/s10461-016-1311-3
PG 10
WC Public, Environmental & Occupational Health; Social Sciences, Biomedical
SC Public, Environmental & Occupational Health; Biomedical Social Sciences
GA EA3KA
UT WOS:000386499800029
PM 26910338
ER
PT J
AU Kardouni, JR
Shing, TL
Rhon, DI
AF Kardouni, Joseph R.
Shing, Tracie L.
Rhon, Daniel I.
TI Risk Factors for Low Back Pain and Spine Surgery A Retrospective Cohort
Study in Soldiers
SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE
LA English
DT Article
ID MILITARY SERVICE MEMBERS; PRIMARY-CARE; DECISION-MAKING; SLEEP;
METAANALYSIS; PREVALENCE; GUIDELINES; MANAGEMENT; DISORDERS; QUALITY
AB Introduction: Musculoskeletal low back pain (LBP) is commonly treated symptomatically, with practice guidelines advocating reserving surgery for cases that fail conservative care. This study examined medical comorbidities and demographic variables as risk factors for chronic/recurrent LBP, spinal surgery, and time to surgery.
Methods: A 2015 retrospective cohort study was conducted in U.S. Army soldiers (N=1,092,420) from 2002 to 2011. Soldiers with medical encounters for LBP were identified using ICD-9 codes. Surgical treatment for LBP was identified according to Current Procedural Terminology codes. Comorbid medical conditions (psychological disorders, sleep disorders, tobacco use, alcohol use, obesity) and demographic variables were examined as risk factors for chronic/recurrent LBP within 1 year of the incident encounter, surgery for LBP, and time to surgery.
Results: Of 383,586 patients with incident LBP, 104,169 (27%) were treated for chronic/recurrent LBP and 7,446 (1.9%) had surgery. Comorbid variables showed increased risk of chronic/recurrent LBP ranging from 26% to 52%. Tobacco use increased risk for surgery by 33% (risk ratio, 1.33; 95% CI=1.24, 1.44). Comorbid variables showed 10%-42% shorter time to surgery (psychological disorders, time ratio [TR]=0.90, 95% CI=0.83, 0.98; sleep disorders, TR=0.68, 95% CI=0.60, 0.78; obesity, TR=0.88, 95% CI=0.79, 0.98; tobacco use, TR=0.58, 95% CI=0.54, 0.63; alcohol use, TR=0.85, 95% CI=0.70, 1.05). Women showed 20% increased risk of chronic/recurrent LBP than men but 42% less risk of surgery.
Conclusions: In the presence of comorbidities associated with mental health, sleep, obesity, tobacco use, and alcohol use, LBP shows increased risk of becoming chronic/recurrent and faster time to surgery. Published by Elsevier Inc. on behalf of American Journal of Preventive Medicine
C1 [Kardouni, Joseph R.; Shing, Tracie L.] US Army Res Inst Environm Med, Natick, MA USA.
[Rhon, Daniel I.] Brooke Army Med Ctr, Ctr Intrepid, Joint Base San Antonio, TX USA.
[Rhon, Daniel I.] Baylor Univ, US Army, Doctoral Program Phys Therapy, San Antonio, TX USA.
RP Kardouni, JR (reprint author), US Army Res Inst Environm Med, Mil Performance Div, 10 Gen Greene Ave,Bldg 42, Natick, MA 01760 USA.
EM joseph.r.kardouni.mil@mail.mil
NR 41
TC 0
Z9 0
U1 4
U2 4
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0749-3797
EI 1873-2607
J9 AM J PREV MED
JI Am. J. Prev. Med.
PD NOV
PY 2016
VL 51
IS 5
BP E129
EP E138
DI 10.1016/j.amepre.2016.06.005
PG 10
WC Public, Environmental & Occupational Health; Medicine, General &
Internal
SC Public, Environmental & Occupational Health; General & Internal Medicine
GA EA7CG
UT WOS:000386785100002
PM 27476385
ER
PT J
AU Cote, I
Andersen, ME
Ankley, GT
Barone, S
Birnbaum, LS
Boekelheide, K
Bois, F
Burgoon, LD
Chiu, WA
Crawford-Brown, D
Crofton, KM
DeVito, M
Devlin, RB
Edwards, SW
Guyton, KZ
Hattis, D
Judson, RS
Knight, D
Krewski, D
Lambert, J
Maull, EA
Mendrick, D
Paoli, GM
Patel, CJ
Perkins, EJ
Poje, G
Portier, CJ
Rusyn, I
Schulte, PA
Simeonov, A
Smith, MT
Thayer, KA
Thomas, RS
Thomas, R
Tice, RR
Vandenberg, JJ
Villeneuve, DL
Wesselkamper, S
Whelan, M
Whittaker, C
White, R
Xia, M
Yauk, C
Zeise, L
Zhao, J
DeWoskin, RS
AF Cote, Ila
Andersen, Melvin E.
Ankley, Gerald T.
Barone, Stanley
Birnbaum, Linda S.
Boekelheide, Kim
Bois, FredericY.
Burgoon, Lyle D.
Chiu, Weihsueh A.
Crawford-Brown, Douglas
Crofton, Kevin M.
DeVito, Michael
Devlin, Robert B.
Edwards, Stephen W.
Guyton, Kathryn Z.
Hattis, Dale
Judson, Richard S.
Knight, Derek
Krewski, Daniel
Lambert, Jason
Maull, Elizabeth Anne
Mendrick, Donna
Paoli, Gregory M.
Patel, Chirag Jagdish
Perkins, Edward J.
Poje, Gerald
Portier, Christopher J.
Rusyn, Ivan
Schulte, Paul A.
Simeonov, Anton
Smith, Martyn T.
Thayer, Kristina A.
Thomas, Russell S.
Thomas, Reuben
Tice, Raymond R.
Vandenberg, John J.
Villeneuve, Daniel L.
Wesselkamper, Scott
Whelan, Maurice
Whittaker, Christine
White, Ronald
Xia, Menghang
Yauk, Carole
Zeise, Lauren
Zhao, Jay
DeWoskin, Robert S.
TI The Next Generation of Risk Assessment Multi-Year Study-Highlights of
Findings, Applications to Risk Assessment, and Future Directions
SO ENVIRONMENTAL HEALTH PERSPECTIVES
LA English
DT Review
ID ADVERSE OUTCOME PATHWAYS; BRONCHIAL EPITHELIAL-CELLS; THROUGHPUT
SCREENING DATA; IN-VIVO HAZARD; ENVIRONMENTAL CHEMICALS; HUMAN HEALTH;
GENE-EXPRESSION; POPULATION VARIABILITY; PREDICTIVE TOXICOLOGY;
ESTROGEN-RECEPTOR
AB BACKGROUND: The Next Generation (NexGen) of Risk Assessment effort is a multi-year collaboration among several organizations evaluating new, potentially more efficient molecular, computational, and systems biology approaches to risk assessment. This article summarizes our findings, suggests applications to risk assessment, and identifies strategic research directions.
OBJECTIVE: Our specific objectives were to test whether advanced biological data and methods could better inform our understanding of public health risks posed by environmental exposures.
METHODS: New data and methods were applied and evaluated for use in hazard identification and dose-response assessment. Biomarkers of exposure and effect, and risk characterization were also examined. Consideration was given to various decision contexts with increasing regulatory and public health impacts. Data types included transcriptomics, genomics, and proteomics. Methods included molecular epidemiology and clinical studies, bioinformatic knowledge mining, pathway and network analyses, short-duration in vivo and in vitro bioassays, and quantitative structure activity relationship modeling.
DISCUSSION: NexGen has advanced our ability to apply new science by more rapidly identifying chemicals and exposures of potential concern, helping characterize mechanisms of action that influence conclusions about causality, exposure-response relationships, susceptibility and cumulative risk, and by elucidating new biomarkers of exposure and effects. Additionally, NexGen has fostered extensive discussion among risk scientists and managers and improved confidence in interpreting and applying new data streams.
CONCLUSIONS: While considerable uncertainties remain, thoughtful application of new knowledge to risk assessment appears reasonable for augmenting major scope assessments, forming the basis for or augmenting limited scope assessments, and for prioritization and screening of very data limited chemicals.
C1 [Cote, Ila; Vandenberg, John J.; DeWoskin, Robert S.] US EPA, Natl Ctr Environm Assessment, Washington, DC 20460 USA.
[Andersen, Melvin E.] ScitoVation, Res Triangle Pk, NC USA.
[Ankley, Gerald T.; Villeneuve, Daniel L.] US EPA, Natl Hlth & Environm Effects Res Lab, Duluth, MN USA.
[Barone, Stanley] US EPA, Off Chem Safety & Pollut Prevent, Washington, DC 20460 USA.
[Birnbaum, Linda S.; DeVito, Michael; Maull, Elizabeth Anne; Thayer, Kristina A.; Tice, Raymond R.] NIEHS, POB 12233, Res Triangle Pk, NC 27709 USA.
[Birnbaum, Linda S.; DeVito, Michael; Maull, Elizabeth Anne; Thayer, Kristina A.; Tice, Raymond R.] NIH, Natl Toxicol Program, DHHS, Res Triangle Pk, NC USA.
[Boekelheide, Kim] Brown Univ, Dept Pathol & Lab Med, Providence, RI 02912 USA.
[Bois, FredericY.] Inst Natl Environm Ind & Risques, Unite Modeles Icotoxicol & Toxicol, Verneuil En Halatte, France.
[Burgoon, Lyle D.] US Army, Engineer Res & Dev Ctr, Res Triangle Pk, NC USA.
[Chiu, Weihsueh A.; Rusyn, Ivan] Texas A&M Univ, Coll Vet Med & Biomed Sci, Dept Vet Integrat Biosci, College Stn, TX USA.
[Crawford-Brown, Douglas] Univ Cambridge, Dept Land Econ, Cambridge, England.
[Crofton, Kevin M.; Judson, Richard S.; Thomas, Russell S.] Natl Ctr Computat Toxicol, Res Triangle Pk, NC USA.
[Devlin, Robert B.; Edwards, Stephen W.] US EPA, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
[Guyton, Kathryn Z.] Int Agcy Res Canc, Lyon, France.
[Hattis, Dale] Clark Univ, George Perkins Marsh Inst, Worcester, MA 01610 USA.
[Knight, Derek] European Chem Agcy, Helsinki, Finland.
[Krewski, Daniel] Univ Ottawa, McLaughlin Ctr Populat Hlth Risk Assessment, Ottawa, ON, Canada.
[Lambert, Jason; Wesselkamper, Scott; Zhao, Jay] US EPA, Natl Ctr Environm Assessment, Cincinnati, OH 45268 USA.
[Mendrick, Donna] US FDA, Natl Ctr Toxicol Res, Jefferson, AR 72079 USA.
[Paoli, Gregory M.] Risk Sci Int, Ottawa, ON, Canada.
[Patel, Chirag Jagdish] Harvard Med Sch, Dept Biomed Informat, Boston, MA USA.
[Perkins, Edward J.] US Army, Engineer Res & Dev Ctr, Vicksburg, MS USA.
[Poje, Gerald] Grant Consulting Grp, Washington, DC USA.
[Portier, Christopher J.] Environm Def Fund, Washington, DE USA.
[Schulte, Paul A.; Whittaker, Christine] Ctr Dis Control & Prevent, Natl Inst Occupat Safety & Hlth, Educ & Informat Div, Cincinnati, OH USA.
[Simeonov, Anton; Xia, Menghang] NIH, Natl Ctr Adv Translat Sci, DHHS, Bethesda, MD USA.
[Smith, Martyn T.] Univ Calif Berkeley, Sch Publ Hlth, Div Environm Hlth Sci, Berkeley, CA 94720 USA.
[Thomas, Reuben] Univ Calif San Francisco, Gladstone Inst, San Francisco, CA 94143 USA.
[Whelan, Maurice] European Commiss Joint Res Ctr, Syst Toxicol Unit, Ispra, Italy.
[White, Ronald] Ctr Effect Govt, Washington, DE USA.
[Yauk, Carole] Hlth Canada, Environm Hlth Sci & Res Bur, Ottawa, ON, Canada.
[Zeise, Lauren] Calif EPA, Off Environm Hlth Hazard Assessment, Oakland, CA USA.
RP Cote, I (reprint author), US EPA, Reg 8,Room 8152,1595 Wynkoop St, Denver, CO 80202 USA.
EM cote.ila@epa.gov
RI Bois, Frederic/E-9241-2012; Rusyn, Ivan/S-2426-2016;
OI Bois, Frederic/0000-0002-4154-0391; Vandenberg,
John/0000-0003-2619-9460; Burgoon, Lyle/0000-0003-4977-5352
FU NIEHS NIH HHS [P42 ES005948, R00 ES023504, K99 ES023504, R21 ES025052]
NR 152
TC 0
Z9 0
U1 30
U2 30
PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
PI RES TRIANGLE PK
PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233,
RES TRIANGLE PK, NC 27709-2233 USA
SN 0091-6765
EI 1552-9924
J9 ENVIRON HEALTH PERSP
JI Environ. Health Perspect.
PD NOV
PY 2016
VL 124
IS 11
BP 1671
EP 1682
DI 10.1289/EHP233
PG 12
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA EA8UF
UT WOS:000386913800010
PM 27091369
ER
PT J
AU Schlussel, AT
Lustik, MB
Cherng, NB
Maykel, JA
Hatch, QM
Steele, SR
AF Schlussel, Andrew T.
Lustik, Michael B.
Cherng, Nicole B.
Maykel, Justin A.
Hatch, Quinton M.
Steele, Scott R.
TI Right-Sided Diverticulitis Requiring Colectomy: an Evolving Demographic?
A Review of Surgical Outcomes from the National Inpatient Sample
Database
SO JOURNAL OF GASTROINTESTINAL SURGERY
LA English
DT Article
DE Diverticulitis; Laparoscopy; Outcome assessment
ID COMPLEX COLORECTAL PROCEDURES; RIGHT COLONIC DIVERTICULITIS; CECAL
DIVERTICULITIS; OPEN SURGERY; DISEASE; MORTALITY; RESECTION
AB There remains a paucity of recent data on right-sided colonic diverticulitis, especially those undergoing colectomy. We sought to describe the clinical features of patients undergoing both a laparoscopic and open surgery for right-sided diverticulitis.
This study is a review of all cases of a right colectomy or ileocecectomy for diverticulitis from the National Inpatient Sample (NIS) from 2006 to 2012. Demographics, comorbidities, and postoperative outcomes were identified for all cases. A comparative analysis of a laparoscopic versus open approach was performed.
We identified 2233 admissions (laparoscopic = 592; open = 1641) in the NIS database. The majority of cases were Caucasian (67 %), with 6 % of NIS cases identified as Asian/Pacific Islander. The overall morbidity and in-hospital mortality rates were 24 and 2.7 %, respectively. The conversion rate from a laparoscopic to open procedure was 34 %. Postoperative complications were greater in the open versus laparoscopic cohorts (25 vs. 19 %, p < 0.01), with pulmonary complications as the highest (7.0 vs. 1.7 %; p < 0.01).
This investigation represents one of the largest cohorts of colon resections to treat right-sided diverticulitis in the USA. In this series, right-sided diverticulitis undergoing surgery occurred most commonly in the Caucasian population and is most often approached via an open surgical technique; however, laparoscopy is a safe and feasible option.
C1 [Schlussel, Andrew T.; Cherng, Nicole B.; Maykel, Justin A.] Univ Massachusetts, Mem Med Ctr, Div Colorectal Surg, 67 Belmont St 201, Worcester, MA 01605 USA.
[Lustik, Michael B.] Tripler Army Med Ctr, Dept Clin Invest, 1 Jarrett White Rd, Honolulu, HI 96859 USA.
[Hatch, Quinton M.] Madigan Army Med Ctr, Dept Gen Surg, 9040a Fitzsimmons Dr, Ft Lewis, WA 98431 USA.
[Steele, Scott R.] Case Western Reserve Univ, Univ Hosp Case Med Ctr, Div Colorectal Surg, 11100 Euclid Ave, Cleveland, OH 44106 USA.
RP Steele, SR (reprint author), Case Western Reserve Univ, Univ Hosp Case Med Ctr, Div Colorectal Surg, 11100 Euclid Ave, Cleveland, OH 44106 USA.
EM Andrew.t.schlussel@gmail.com; michael.b.lustik.civ@mail.mil;
nicole.cherng@gmail.com; justin.maykel@umassmemorial.org;
qhatch@gmail.com; harkersteele@mac.com
NR 33
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1091-255X
EI 1873-4626
J9 J GASTROINTEST SURG
JI J. Gastrointest. Surg.
PD NOV
PY 2016
VL 20
IS 11
BP 1874
EP 1885
DI 10.1007/s11605-016-3233-9
PG 12
WC Gastroenterology & Hepatology; Surgery
SC Gastroenterology & Hepatology; Surgery
GA EB0KH
UT WOS:000387032200013
PM 27619806
ER
PT J
AU Taylor, BJ
Mulkijanyan, K
Chitiashvili, L
Ramishvili, M
Mchedlishvili, K
AF Taylor, Brett J.
Mulkijanyan, Karen
Chitiashvili, Levan
Ramishvili, Marika
Mchedlishvili, Kakha
TI An overview of laboratory animal science in the nation of Georgia
SO LAB ANIMAL
LA English
DT News Item
C1 [Taylor, Brett J.] United States Army, Walter Reed Army Inst Res, Silver Spring, MD 20910 USA.
[Mulkijanyan, Karen] Tbilisi State Med Univ, Kutateladze Inst Pharmacochem, Tbilisi, Rep of Georgia.
[Chitiashvili, Levan; Ramishvili, Marika] Natl Ctr Dis Control & Publ Hlth, Tbilisi, Rep of Georgia.
[Mchedlishvili, Kakha] Tbilisi State Univ, Dept Immunol & Microbiol, Tbilisi, Rep of Georgia.
RP Taylor, BJ (reprint author), United States Army, Walter Reed Army Inst Res, Silver Spring, MD 20910 USA.
EM brett.j.taylor2.mil@mail.mil
NR 0
TC 0
Z9 0
U1 2
U2 2
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0093-7355
EI 1548-4475
J9 LAB ANIMAL
JI Lab Anim.
PD NOV
PY 2016
VL 45
IS 11
BP 415
EP 417
PG 3
WC Veterinary Sciences
SC Veterinary Sciences
GA EA3ZI
UT WOS:000386547400011
PM 27763619
ER
PT J
AU Santra, S
Balu, R
AF Santra, Siddhartha
Balu, Radhakrishnan
TI Propagation of correlations in local random quantum circuits
SO QUANTUM INFORMATION PROCESSING
LA English
DT Article
DE Random quantum circuits; Quantum correlations; Spin chains; Super
operators; Quantum many-body systems
AB We derive a dynamical bound on the propagation of correlations in local random quantum circuits-lattice spin systems where piecewise quantum operations-in space and time-occur with classical probabilities. Correlations are quantified by the Frobenius norm of the commutator of two positive operators acting on disjoint regions of a one-dimensional circular chain of length L. For a time t = O (L) correlations spread ballistically to spatial distances D = t, growing at best, diffusively with time for any distance within that radius with extensively suppressed distance- dependent corrections. For t = Omega (L-2) , all parts of the system get almost equally correlated with exponentially suppressed distance- dependent corrections and approach the maximum amount of correlations that may be established asymptotically.
C1 [Santra, Siddhartha; Balu, Radhakrishnan] US Army Res Lab, Computat & Informat Sci Directorate, Adelphi, MD 20783 USA.
[Balu, Radhakrishnan] US Army Res Lab, Computat & Informat Sci Directorate, ATTN CIH N, Aberdeen Proving Ground, MD 21005 USA.
RP Balu, R (reprint author), US Army Res Lab, Computat & Informat Sci Directorate, Adelphi, MD 20783 USA.; Balu, R (reprint author), US Army Res Lab, Computat & Informat Sci Directorate, ATTN CIH N, Aberdeen Proving Ground, MD 21005 USA.
EM santra@stanford.edu; radhakrishnan.balu.civ@mail.mil
NR 21
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PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1570-0755
EI 1573-1332
J9 QUANTUM INF PROCESS
JI Quantum Inf. Process.
PD NOV
PY 2016
VL 15
IS 11
BP 4613
EP 4628
DI 10.1007/s11128-016-1412-y
PG 16
WC Physics, Multidisciplinary; Physics, Mathematical
SC Physics
GA EA6ZJ
UT WOS:000386777400014
ER
PT J
AU Hariharan, N
Wissink, A
Potsdam, M
Strawn, R
AF Hariharan, Nathan
Wissink, Andrew
Potsdam, Mark
Strawn, Roger
TI First-Principles Physics-Based Rotorcraft Flowfield Simulation Using
HPCMP CREATE-AV Helios
SO COMPUTING IN SCIENCE & ENGINEERING
LA English
DT Article
AB The flowfield around a helicopter's spinning rotor is difficult to model due to its unsteadiness and strong vorticity. The underlying issue in modeling rotorcraft flowfields is the necessity to correctly account for the complex vortex wake produced by the rotor.
C1 [Hariharan, Nathan] US Dept Def, HPCMP, Washington, DC 20301 USA.
[Wissink, Andrew; Potsdam, Mark; Strawn, Roger] US Army, Ft Eustis, VA USA.
RP Hariharan, N (reprint author), US Dept Def, HPCMP, Washington, DC 20301 USA.
EM nathan.hariharan.ctr@hpc.mil; andrew.m.wissink.civ@mail.mil;
mark.a.potsdam.civ@mail.mil; roger.c.strawn.civ@mail.mil
FU US Department of Defense HPC Modernization Program Office
FX Part of the material presented in this article is a product of the HPCMP
CREATE-AV Element of the Computational Research and Engineering for
Acquisition Tools and Environments (CREATE) program sponsored by the US
Department of Defense HPC Modernization Program Office. Robert Meakin is
the program manager for CREATE-AV.
NR 24
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U1 1
U2 1
PU IEEE COMPUTER SOC
PI LOS ALAMITOS
PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1314 USA
SN 1521-9615
EI 1558-366X
J9 COMPUT SCI ENG
JI Comput. Sci. Eng.
PD NOV-DEC
PY 2016
VL 18
IS 6
BP 19
EP 26
PG 8
WC Computer Science, Interdisciplinary Applications
SC Computer Science
GA EA2GY
UT WOS:000386412000004
ER
PT J
AU Spinella, PC
Cap, AP
AF Spinella, Philip C.
Cap, Andrew P.
TI Whole blood: back to the future
SO CURRENT OPINION IN HEMATOLOGY
LA English
DT Review
DE coagulopathy; hemorrhage; shock; transfusion; trauma
ID DAMAGE CONTROL RESUSCITATION; FLUID RESUSCITATION; IN-VITRO; HEMOSTATIC
EFFECTIVENESS; TRAUMA RESUSCITATION; TRANSFUSION POLICIES; HUMAN
PLATELETS; HEART-SURGERY; REFRIGERATION; COAGULOPATHY
AB Purpose of reviewWe present data comparing whole blood with blood components and summarize the data that support increased availability of whole blood for patients with life-threatening bleeding.Recent findingsRecent data indicate that whole-blood transfusion is associated with improved or comparable survival compared with resuscitation with blood components. These data complement randomized controlled trials indicating that platelet-containing blood products stored at 4 degrees C have superior hemostatic function, compared with platelet-containing blood products at 22 degrees C. Whole blood is rarely available in civilian hospitals and, thus, is rarely transfused into patients with hemorrhagic shock. Misconceptions that whole blood must be ABO specific, that whole blood cannot be leukoreduced and maintain platelets, and that cold storage causes loss of platelet function have limited its availability. Understanding that these barriers are not insurmountable will improve the availability of whole blood and facilitate its use. In addition, there are logistical advantages of whole-blood-based resuscitation, as compared with component therapy, for hemorrhagic shock.SummaryLow titer Group O whole blood stored for up to 21 days at 4 degrees C merits further study to compare its efficacy and safety with current resuscitation approaches for patients with life-threatening bleeding.
C1 [Spinella, Philip C.] Washington Univ, Dept Pediat, Div Crit Care, St Louis, MO 63130 USA.
[Spinella, Philip C.; Cap, Andrew P.] US Army Inst Surg Res, JBSA FT Sam Houston, Houston, TX USA.
RP Spinella, PC (reprint author), Washington Univ, Sch Med, Pediat Crit Care Translat Res Program, Campus Box 8116,One Childrens Pl, St Louis, MO 63110 USA.; Spinella, PC (reprint author), Washington Univ, Sch Med, Blood Res Program, Campus Box 8116,One Childrens Pl, St Louis, MO 63110 USA.; Spinella, PC (reprint author), Washington Univ, Sch Med, Dept Pediat, Campus Box 8116,One Childrens Pl, St Louis, MO 63110 USA.
EM spinella_p@kids.wustl.edu
NR 47
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U1 6
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1065-6251
EI 1531-7048
J9 CURR OPIN HEMATOL
JI Curr. Opin. Hematol.
PD NOV
PY 2016
VL 23
IS 6
BP 536
EP 542
DI 10.1097/MOH.0000000000000284
PG 7
WC Hematology
SC Hematology
GA EA1GN
UT WOS:000386340600008
PM 27607444
ER
PT J
AU Pellegrino, PR
Schiller, AM
Haack, KKV
Zucker, IH
AF Pellegrino, Peter R.
Schiller, Alicia M.
Haack, Karla K. V.
Zucker, Irving H.
TI Central Angiotensin-II Increases Blood Pressure and Sympathetic Outflow
via Rho Kinase Activation in Conscious Rabbits
SO HYPERTENSION
LA English
DT Article
DE angiotensin II; baroreflex; cardiovascular diseases; hypertension;
intraventricular infusions; RhoA GTP-binding protein; Rho-associated
kinases
ID CHRONIC HEART-FAILURE; NITRIC-OXIDE SYNTHASE; BRAIN-STEM CONTRIBUTES;
ARTERIAL-PRESSURE; POSSIBLE INVOLVEMENT; MEDIATED INCREASE; NERVE
DISCHARGE; NAD(P)H OXIDASE; AT(1) RECEPTORS; NEURAL-CONTROL
AB Elevated sympathetic tone and activation of the renin-angiotensin system are pathophysiologic hallmarks of hypertension, and the interactions between these systems are particularly deleterious. The importance of Rho kinase as a mediator of the effects of angiotensin-II (AngII) in the periphery is clear, but the role of Rho kinase in sympathoexcitation caused by central AngII is not well established. We hypothesized that AngII mediates its effects in the brain by the activation of the RhoA/Rho kinase pathway. Chronically instrumented, conscious rabbits received the following intracerebroventricular infusion treatments for 2 weeks via osmotic minipump: AngII, Rho kinase inhibitor Fasudil, AngII plus Fasudil, or a vehicle control. AngII increased mean arterial pressure over the course of the infusion, and this effect was prevented by the coadministration of Fasudil. AngII increased cardiac and vascular sympathetic outflow as quantified by the heart rate response to metoprolol and the depressor effect of hexamethonium; coadministration of Fasudil abolished both of these effects. AngII increased baseline renal sympathetic nerve activity in conscious animals and impaired baroreflex control of sympathetic nerve activity; again Fasudil coinfusion prevented these effects. Each of these end points showed a statistically significant interaction between AngII and Fasudil. Quantitative immunofluorescence of brain slices confirmed that Rho kinase activity was increased by AngII and decreased by Fasudil. Taken together, these data indicate that hypertension, elevated sympathetic outflow, and baroreflex dysfunction caused by central AngII are mediated by Rho kinase activation and suggest that Rho kinase inhibition may be an important therapeutic target in sympathoexcitatory cardiovascular diseases.
C1 [Pellegrino, Peter R.; Schiller, Alicia M.; Zucker, Irving H.] Univ Nebraska Med Ctr, Dept Cellular & Integrat Physiol, Omaha, NE USA.
[Schiller, Alicia M.] US Army Inst Surg Res, Ft Sam Houston, TX USA.
[Haack, Karla K. V.] Emory Univ, Sch Med, Dept Pediat, Atlanta, GA USA.
RP Zucker, IH (reprint author), 985850 Nebraska Med Ctr, Omaha, NE 68198 USA.
EM izucker@unmc.edu
FU National Institutes of Health National Heart, Lung, and Blood Institute
(NIH NHLBI) [P01 HL62222]; NIH NHLBI [F30 HL118974, F32 HL116172];
American Heart Association (AHA) [13PRE16210015]; AHA [13PRE14700045]
FX This work was supported by National Institutes of Health National Heart,
Lung, and Blood Institute (NIH NHLBI) grant P01 HL62222. P.R. Pellegrino
was partially supported by NIH NHLBI grant F30 HL118974 and American
Heart Association (AHA) award 13PRE16210015. A.M. Schiller was partially
supported by AHA award 13PRE14700045. K.K.V. Haack was partially
supported by NIH NHLBI F32 HL116172.
NR 77
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U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0194-911X
EI 1524-4563
J9 HYPERTENSION
JI Hypertension
PD NOV
PY 2016
VL 68
IS 5
BP 1271
EP 1280
DI 10.1161/HYPERTENSIONAHA.116.07792
PG 10
WC Peripheral Vascular Disease
SC Cardiovascular System & Cardiology
GA DZ9VE
UT WOS:000386227500031
PM 27672026
ER
PT J
AU Cox, BC
Howard, IL
AF Cox, Ben C.
Howard, Isaac L.
TI Cold In-Place Recycling Characterization for Single-Component or
Multiple-Component Binder Systems
SO JOURNAL OF MATERIALS IN CIVIL ENGINEERING
LA English
DT Article
DE Cold in-place recycling; Multiple-component binder systems; Asphalt
emulsion; Portland cement; Sustainability; Triple bottom line
ID HOT-MIX ASPHALT; PERFORMANCE; MIXTURES
AB Cold in-place recycling (CIR) is a pavement rehabilitation technique that has been used for decades. During this time, single-component binder (SCB) systems have governed the market. Single-component binders are defined as those with one binder or two if the secondary binder dosage is 1% or less (e.g.,3% asphalt emulsion with 1% hydrated lime). In contrast, this paper investigates multiple-component binder (MCB) systems (e.g.,2.5% emulsion with 2% portland cement). This paper's objective is threefold: (1)present a universal CIR design framework applicable to any cementitious and/or bituminous material; (2)demonstrate MCB sustainability advantages; and (3)conduct an extensive SCB and MCB characterization. Universal design framework components include specimen preparation, curing, and testing protocols. Nine binder combinations were tested for wheel tracking, permeability, modulus, strength, and cracking response. Cement SCBs yielded low cracking resistance, high rutting resistance, and favorable economics; emulsion SCBs yielded the opposite. Multiple-component binders balanced cracking, rutting, and economics. The work presented in this paper could benefit agencies in many ways, for example, by promoting informed decisions regarding CIR performance and economics. (C) 2016 American Society of Civil Engineers.
C1 [Cox, Ben C.] US Army, Engineer Res & Dev Ctr, CEERD GMA, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
[Cox, Ben C.] Mississippi State Univ, Dept Civil & Environm Engn, 501 Hardy Rd,POB 9546, Mississippi State, MS 39762 USA.
[Howard, Isaac L.] Mississippi State Univ, Dept Civil & Environm Engn, Mat & Construct Ind Chair, 501 Hardy Rd,POB 9546, Mississippi State, MS 39762 USA.
RP Cox, BC (reprint author), US Army, Engineer Res & Dev Ctr, CEERD GMA, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
EM benjamin.c.cox@erdc.dren.mil; ilhoward@cee.msstate.edu
FU MDOT; Ergon Asphalt and Emulsions Distinguished Doctoral Fellowship in
Construction Materials
FX Thanks are due to MDOT for funding State Study 250. Additional financial
support was available through the Ergon Asphalt and Emulsions
Distinguished Doctoral Fellowship in Construction Materials held by Ben
C. Cox. Thanks are due to Gaylon Baumgardner, Paul Morris, Mike Hemsley,
and Trey Jordan of Paragon Technical Services, Inc., and Tim Cost of
Holcim (US), Inc., for providing materials and support. Thanks are due
to Dr. Don Christensen for providing the LTSTRESS.xls spreadsheet. The
University of Florida (specifically Dr. Reynaldo Roque, Dr. Jian Zou,
and George Lopp) was very helpful and forthcoming regarding past
experiences with cracking characterization testing. Thanks are due to
Mississippi State University undergraduate research assistants Chase
Hopkins, Drew Moore, and Matt Roddy for assistance with laboratory
activities. Permission to publish was granted by the director of
Geotechnical and Structures Laboratory.
NR 37
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U2 8
PU ASCE-AMER SOC CIVIL ENGINEERS
PI RESTON
PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA
SN 0899-1561
EI 1943-5533
J9 J MATER CIVIL ENG
JI J. Mater. Civ. Eng.
PD NOV
PY 2016
VL 28
IS 11
AR 04016118
DI 10.1061/(ASCE)MT.1943-5533.0001621
PG 13
WC Construction & Building Technology; Engineering, Civil; Materials
Science, Multidisciplinary
SC Construction & Building Technology; Engineering; Materials Science
GA EA1PZ
UT WOS:000386365600006
ER
PT J
AU Rushing, TW
Howard, IL
Jordon, JB
Allison, PG
AF Rushing, Timothy W.
Howard, Isaac L.
Jordon, J. Brian
Allison, Paul G.
TI Laboratory Characterization of Fatigue Performance of AM2 Aluminum
Airfield Matting
SO JOURNAL OF MATERIALS IN CIVIL ENGINEERING
LA English
DT Article
DE Airfield mat; Full-scale tests; Fatigue; Aluminum mat; Structural mat
ID SYSTEMS; ALLOYS
AB AM2, an airfield matting system made from extruded 6061-T6 aluminum alloy, is used to construct temporary aircraft operating surfaces. This matting system can support heavy aircraft loads even when placed directly over graded in situ soils. This paper presents the development of a test protocol and corresponding relationships that can be used to predict fatigue failure of AM2's mechanical joints over any subgrade California bearing ratio (CBR) when subjected to high tire pressure single-wheel aircraft loading. First, full-scale simulated aircraft traffic experiments were conducted over sections of AM2 installed on subgrades with CBRs of 6, 10, 15, 25, and 100% to monitor subgrade deformation and fatigue failure. An increasing amplitude displacement function developed from a subgrade deformation model was then used to create a new laboratory procedure to simulate fatigue experienced by the matting system's complex mechanical connectors under moving aircraft loads. Laboratory test results had strong correlations with field data and, therefore, have promise for predicting fatigue performance without the expense of full-scale experiments. (C) 2016 American Society of Civil Engineers.
C1 [Rushing, Timothy W.] US Army, ERDC, Airfields & Pavements Branch, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
[Rushing, Timothy W.] Mississippi State Univ, Dept Civil & Environm Engn, Mississippi State, MS 39762 USA.
[Howard, Isaac L.] Mississippi State Univ, Dept Civil & Environm Engn, Mat & Construct Ind Chair, 235F Walker Engn Bldg,POB 9546, Mississippi State, MS 39762 USA.
[Jordon, J. Brian; Allison, Paul G.] Univ Alabama, Dept Mech Engn, 1023 NERC, Tuscaloosa, AL 35487 USA.
RP Rushing, TW (reprint author), US Army, ERDC, Airfields & Pavements Branch, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.; Rushing, TW (reprint author), Mississippi State Univ, Dept Civil & Environm Engn, Mississippi State, MS 39762 USA.
EM timothy.w.rushing@usace.army.mil; ilhoward@cee.msstate.edu;
bjordon@eng.ua.edu; pallison@eng.ua.edu
FU U.S. Air Force Civil Engineer Center (AFCEC); office of the Assistant
Secretary of the Army for Acquisitions, Logistics, and Technology
(ASAALT); AFCEC; ASAALT; ERDC personnel
FX The full-scale and laboratory experiments and resulting data presented
in this paper were obtained from research conducted at the U.S. Army
ERDC, Geotechnical and Structures Laboratory (GSL), Airfields and
Pavements Branch with funds provided by the U.S. Air Force Civil
Engineer Center (AFCEC) and the office of the Assistant Secretary of the
Army for Acquisitions, Logistics, and Technology (ASAALT). The sponsors
determined the scope of the study but did not assist in data collection,
analysis, or writing. The support of AFCEC, ASAALT, and ERDC personnel
is gratefully acknowledged. A special thank you goes to Mr. Jeb Tingle,
Mr. Quint Mason, Mr. Tim McCaffrey, and Ms. Lyan Garcia of the ERDC GSL
who were instrumental in the successful completion of this research.
Permission to publish this work was granted by the Director,
Geotechnical and Structures Laboratory.
NR 25
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U1 3
U2 3
PU ASCE-AMER SOC CIVIL ENGINEERS
PI RESTON
PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA
SN 0899-1561
EI 1943-5533
J9 J MATER CIVIL ENG
JI J. Mater. Civ. Eng.
PD NOV
PY 2016
VL 28
IS 11
AR 04016134
DI 10.1061/(ASCE)MT.1943-5533.0001620
PG 9
WC Construction & Building Technology; Engineering, Civil; Materials
Science, Multidisciplinary
SC Construction & Building Technology; Engineering; Materials Science
GA EA1PZ
UT WOS:000386365600005
ER
PT J
AU Lee, GO
Richard, SA
Kang, G
Houpt, ER
Seidman, JC
Pendergast, LL
Bhutta, ZA
Ahmed, T
Mduma, ER
Lima, AA
Bessong, P
Jennifer, MS
Hossain, MI
Chandyo, RK
Nyathi, E
Lima, IF
Pascal, J
Soofi, S
Ladaporn, B
Guerrant, RL
Caulfield, LE
Black, RE
Kosek, MN
AF Lee, Gwenyth O.
Richard, Stephanie A.
Kang, Gagandeep
Houpt, Eric R.
Seidman, Jessica C.
Pendergast, Laura L.
Bhutta, Zulfiqar A.
Ahmed, Tahmeed
Mduma, Estomih R.
Lima, Aldo A.
Bessong, Pascal
Jennifer, Mats Steffi
Hossain, Md Iqbal
Chandyo, Ram Krishna
Nyathi, Emanuel
Lima, Ila F.
Pascal, John
Soofi, Sajid
Ladaporn, Bodhidatta
Guerrant, Richard L.
Caulfield, Laura E.
Black, Robert E.
Kosek, Margaret N.
CA MAL-ED Network Investigators
TI A Comparison of Diarrheal Severity Scores in the MAL-ED Multisite
Community-Based Cohort Study
SO JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
LA English
DT Article
DE diarrhea; epidemiology; pediatric
ID ROTAVIRUS GASTROENTERITIS; DEVELOPING-COUNTRIES; CHILDREN; DISEASE;
SURVEILLANCE; DEFINITION; EPISODES; ISSUES; SCALES
AB Objectives:There is a lack of consensus on how to measure diarrheal severity. Within the context of a multisite, prospective cohort study, we evaluated the performance of a modified Vesikari score (MAL-ED), 2 previously published scores (Clark and CODA [a diarrheal severity score (Community DiarrheA) published by Lee et al]), and a modified definition of moderate-to-severe diarrhea (MSD) based on dysentery and health care worker diagnosed dehydration.Methods:Scores were built using maternally reported symptoms or fieldworker-reported clinical signs obtained during the first 7 days of a diarrheal episode. The association between these and the risk of hospitalization were tested using receiver operating characteristic analysis. Severity scores were also related to illness etiology, and the likelihood of the episode subsequently becoming prolonged or persistent.Results:Of 10,159 episodes from 1681 children, 143 (4.0%) resulted in hospitalization. The area under the curve of each score as a predictor of hospitalization was 0.84 (95% confidence interval: 0.81, 0.87) (Clark), 0.85 (0.82, 0.88) (MAL-ED), and 0.87 (0.84, 0.89) (CODA). Severity was also associated with etiology and episode duration. Although families were more likely to seek care for severe diarrhea, approximately half of severe cases never reached the health system.Conclusions:Community-based diarrheal severity scores are predictive of relevant child health outcomes. Because they require no assumptions about health care access or utilization, they are useful in refining estimates of the burden of diarrheal disease, in estimating the effect of disease control interventions, and in triaging children for referral in low- and middle-income countries in which the rates of morbidity and mortality after diarrhea remain high.
C1 [Lee, Gwenyth O.; Caulfield, Laura E.; Black, Robert E.; Kosek, Margaret N.] Johns Hopkins Bloomberg Sch Publ Hlth, 615N Wolfe St,Room E5545, Baltimore, MD 21205 USA.
[Richard, Stephanie A.; Seidman, Jessica C.] NIH, Fogarty Int Ctr, Bldg 10, Bethesda, MD 20892 USA.
[Kang, Gagandeep; Jennifer, Mats Steffi] Christian Med Coll & Hosp, Vellore, Tamil Nadu, India.
[Houpt, Eric R.; Guerrant, Richard L.] Univ Virginia, Charlottesville, VA USA.
[Pendergast, Laura L.] Temple Univ, Philadelphia, PA 19122 USA.
[Bhutta, Zulfiqar A.; Soofi, Sajid] Aga Khan Univ, Karachi, Pakistan.
[Ahmed, Tahmeed; Hossain, Md Iqbal] Icddr B, Dhaka, Bangladesh.
[Mduma, Estomih R.; Pascal, John] Haydom Lutheran Hosp, Haydom, Manyara Region, Tanzania.
[Lima, Aldo A.; Lima, Ila F.] Univ Fed Ceara, Fortaleza, Ceara, Brazil.
[Bessong, Pascal; Nyathi, Emanuel] Univ Venda, Thohoyandou, South Africa.
[Chandyo, Ram Krishna] Univ Bergen, Ctr Int Hlth, Bergen, Norway.
[Chandyo, Ram Krishna] Tribhuvan Univ, Inst Med, Dept Child Hlth, Kathmandu, Nepal.
[Ladaporn, Bodhidatta] Armed Forces Res Inst Med Sci, Bangkok, Thailand.
RP Kosek, MN (reprint author), Johns Hopkins Bloomberg Sch Publ Hlth, 615N Wolfe St,Room E5545, Baltimore, MD 21205 USA.
EM mkosek@jhmi.edu
FU Bill & Melinda Gates Foundation; Foundation for the NIH; National
Institutes of Health, Fogarty International Center
FX The Etiology, Risk Factors, and Interactions of Enteric Infections and
Malnutrition and the Consequences for Child Health and Development
Project (MAL-ED) is carried out as a collaborative project supported by
the Bill & Melinda Gates Foundation, the Foundation for the NIH, and the
National Institutes of Health, Fogarty International Center.
NR 25
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PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0277-2116
EI 1536-4801
J9 J PEDIATR GASTR NUTR
JI J. Pediatr. Gastroenterol. Nutr.
PD NOV
PY 2016
VL 63
IS 5
BP 466
EP 473
DI 10.1097/MPG.0000000000001286
PG 8
WC Gastroenterology & Hepatology; Nutrition & Dietetics; Pediatrics
SC Gastroenterology & Hepatology; Nutrition & Dietetics; Pediatrics
GA EA1KE
UT WOS:000386350200016
PM 27347723
ER
PT J
AU Swain, NR
Christensen, SD
Snow, AD
Dolder, H
Espinoza-Davalos, G
Goharian, E
Jones, NL
Nelson, EJ
Ames, DP
Burian, SJ
AF Swain, Nathan R.
Christensen, Scott D.
Snow, Alan D.
Dolder, Herman
Espinoza-Davalos, Gonzalo
Goharian, Erfan
Jones, Norman L.
Nelson, E. James
Ames, Daniel P.
Burian, Steven J.
TI A new open source platform for lowering the barrier for environmental
web app development
SO ENVIRONMENTAL MODELLING & SOFTWARE
LA English
DT Article
DE Tethys platform; Web app development; Environmental; Decision support;
Hydrologic modeling
ID DATA ASSIMILATION SYSTEM; WATER; MODEL; TOOL; SERVICES; PYTHON
AB The interactive nature of web applications or "web apps" makes them a well-suited medium for conveying complex scientific concepts to lay audiences and creating decision support tools that harness cutting edge modeling techniques and promote the work of environmental scientists and engineers. Despite this potential, the technical expertise required to develop web apps represents a formidable barrier even for scientists and engineers who are skilled programmers. This paper describes four hurdles that contribute to this barrier and introduces an approach to overcoming these hurdles. We present an open source implementation of this approach, a development and hosting environment for environmental web apps called Tethys Platform. Several case studies are provided that demonstrates how the approach, as implemented within Tethys Platform, successfully lowers the barrier to web app development in the environmental domain. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Swain, Nathan R.; Dolder, Herman] Aquaveo LLC, Provo, UT 84604 USA.
[Christensen, Scott D.] US Army, Informat & Technol Lab, Engineer Res & Dev Ctr, Vicksburg, MS USA.
[Snow, Alan D.] US Army, Coastal & Hydraul Lab, Engineer Res & Dev Ctr, Vicksburg, MS USA.
[Espinoza-Davalos, Gonzalo] UNESCO IHE, Dept Integrated Water Syst & Governance, Delft, Netherlands.
[Goharian, Erfan] Univ Calif Davis, Dept Land Air & Water Resource, Davis, CA 95616 USA.
[Jones, Norman L.; Nelson, E. James; Ames, Daniel P.] Brigham Young Univ, Civil & Environm Engn, Provo, UT 84602 USA.
[Burian, Steven J.] Univ Utah, Civil & Environm Engn, Salt Lake City, UT USA.
RP Swain, NR (reprint author), Aquaveo LLC, Provo, UT 84604 USA.
EM nswain@aquaveo.com
OI Snow, Alan/0000-0002-7333-3100; Espinoza-Davalos,
Gonzalo/0000-0002-8137-7525; Swain, Nathan/0000-0002-4741-3828; Burian,
Steven/0000-0003-0523-4968
FU National Science Foundation [1135482]
FX This material is based upon work supported by the National Science
Foundation under Grant No. 1135482.
NR 58
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U1 6
U2 6
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1364-8152
EI 1873-6726
J9 ENVIRON MODELL SOFTW
JI Environ. Modell. Softw.
PD NOV
PY 2016
VL 85
BP 11
EP 26
DI 10.1016/j.envsoft.2016.08.003
PG 16
WC Computer Science, Interdisciplinary Applications; Engineering,
Environmental; Environmental Sciences
SC Computer Science; Engineering; Environmental Sciences & Ecology
GA DZ1JX
UT WOS:000385595800002
ER
PT J
AU Ter-Gabrielyan, N
Fromzel, V
Dubinskii, M
AF Ter-Gabrielyan, N.
Fromzel, V.
Dubinskii, M.
TI Record-low quantum defect operation of an eye-safe Er-doped laser
SO LASER PHYSICS LETTERS
LA English
DT Letter
DE laser; laser materials; Er-doped lasers; single crystal; quantum defect
ID TEMPERATURE; PERFORMANCE; CRYSTALS; YVO4
AB Several new laser transitions from a resonantly-pumped Er3+:YVO4 laser have been demonstrated. Laser operation with quantum defect as low as 0.82% has been achieved. We believe that this is the lowest quantum defect operation ever reported for an eye-safe laser.
C1 [Ter-Gabrielyan, N.; Fromzel, V.; Dubinskii, M.] US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
RP Ter-Gabrielyan, N (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM nikolay.e.ter-gabrielyan.civ@mail.mil
NR 17
TC 0
Z9 0
U1 6
U2 6
PU IOP PUBLISHING LTD
PI BRISTOL
PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
SN 1612-2011
EI 1612-202X
J9 LASER PHYS LETT
JI Laser Phys. Lett.
PD NOV
PY 2016
VL 13
IS 11
AR 115001
DI 10.1088/1612-2011/13/11/115001
PG 4
WC Optics; Physics, Applied
SC Optics; Physics
GA DZ0IK
UT WOS:000385521500001
ER
PT J
AU Abrams, MA
Greb, MD
Collister, JW
Thompson, M
AF Abrams, Michael A.
Greb, Matthias D.
Collister, James W.
Thompson, Melissa
TI Egypt far Western Desert basins petroleum charge system as defined by
oil chemistry and unmixing analysis
SO MARINE AND PETROLEUM GEOLOGY
LA English
DT Article
DE Petroleum systems; Petroleum geochemistry; Reservoir charge analysis;
Reservoir unmixing analysis
ID GEOCHEMICAL CHARACTERISTICS; LIGHT-HYDROCARBONS; CRUDE OILS; SOURCE
ROCKS; NORTHERN
AB Source rock analysis and maturity modeling in Egypt's Far Western Desert basins indicates that several Jurassic and Cretaceous petroleum source rocks could be mature and expelling hydrocarbons over much of the area. Highly variable oil characteristics suggest that more than one charge system may be present. Reservoir crude oil chemistry indicates that the fluids originated from a single source fades generated over a wide range of organic maturity. Secondary alteration mechanisms include water washing, biodegradation, and evaporative fractionation. Crude oils in the upper reservoirs tend to be most affected by biodegradation and water washing. Condensates and light crude oils in the deepest reservoirs appear to be the residual phase from evaporative fractionation.
The broad variation in fluid properties and chromatogram character can be attributed to a multi end member mixing system: early mature waxy oil, later high maturity volatile oil, low level biodegradation, migrated phase evaporative fractionation, and residual phase evaporative fractionation. A statistical "unmixing" algorithm was used to determine end-member compositions and relative mixing proportions for each crude oil sample. Remigration and mixing of the products from multi-phase generation and alteration results in complex reservoir fluid compositions, such that no single reservoired oil represents a compositional end-member, rather the oil samples are mixtures of various amounts of multiple end-members. Mixing proportions show regional trends and variations in different reservoirs within a single field. The crude oil geochemical data and unmixing analysis support a complex charge history from a single source rock, rather than mixing of oils from two source rocks. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Abrams, Michael A.; Greb, Matthias D.] Apache Explorat & Prod Technol, Houston, TX 77056 USA.
[Collister, James W.] USA, Washington, DC USA.
[Thompson, Melissa] Apache Egypt Co, Houston, TX USA.
[Abrams, Michael A.] Imperial Coll, London, England.
[Greb, Matthias D.] Univ Utah, Energy & Geosci Inst, Salt Lake City, UT 84112 USA.
[Thompson, Melissa] Quadrant Energy, Perth, WA, Australia.
RP Abrams, MA (reprint author), Apache Explorat & Prod Technol, Houston, TX 77056 USA.; Abrams, MA (reprint author), Imperial Coll, London, England.
EM m.abramstx@gmail.com
NR 33
TC 0
Z9 0
U1 2
U2 2
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0264-8172
EI 1873-4073
J9 MAR PETROL GEOL
JI Mar. Pet. Geol.
PD NOV
PY 2016
VL 77
BP 54
EP 74
DI 10.1016/j.marpetgeo.2016.05.035
PG 21
WC Geosciences, Multidisciplinary
SC Geology
GA DY1NJ
UT WOS:000384861400005
ER
PT J
AU Sanchez, A
Wu, WM
Beck, TM
AF Sanchez, Alejandro
Wu, Weiming
Beck, Tanya M.
TI A depth-averaged 2-D model of flow and sediment transport in coastal
waters
SO OCEAN DYNAMICS
LA English
DT Article
DE Shallow water flow; Nonuniform sediment transport; Coastal
morphodynamics; Two-dimensional; Finite volume method
ID RANDOM WAVE TRANSFORMATION; ENERGY-BALANCE-EQUATION; BED-LOAD TRANSPORT;
MORPHODYNAMIC MODEL; UNIFIED VIEW; CURRENTS
AB A depth-averaged 2-D model has been developed to simulate unsteady flow and nonuniform sediment transport in coastal waters. The current motion is computed by solving the phase-averaged 2-D shallow water flow equations reformulated in terms of total-flux velocity, accounting for the effects of wave radiation stresses and general diffusion or mixing induced by current, waves, and wave breaking. The cross-shore boundary conditions are specified by assuming fully developed longshore current and wave setup that are determined using the reduced 1-D momentum equations. A 2-D wave spectral transformation model is used to calculate the wave height, period, direction, and radiation stresses, and a surface wave roller model is adopted to consider the effects of surface roller on the nearshore currents. The nonequilibrium transport of nonuniform total-load sediment is simulated, considering sediment entrainment by current and waves, the lag of sediment transport relative to the flow, and the hiding and exposure effect of nonuniform bed material. The flow and sediment transport equations are solved using an implicit finite volume method on a variety of meshes including nonuniform rectangular, telescoping (quadtree) rectangular, and hybrid triangular/quadrilateral meshes. The flow and wave models are integrated through a carefully designed steering process. The model has been tested in three field cases, showing generally good performance.
C1 [Sanchez, Alejandro] US Army, Hydrol Engn Ctr, Corps Engineers, Davis, CA USA.
[Sanchez, Alejandro; Beck, Tanya M.] US Army, Coastal & Hydraul Lab, Corps Engineers, Ctr Res & Dev, Vicksburg, MS 39180 USA.
[Wu, Weiming] Clarkson Univ, Dept Civil & Environm Engn, Potsdam, NY 13699 USA.
RP Wu, WM (reprint author), Clarkson Univ, Dept Civil & Environm Engn, Potsdam, NY 13699 USA.
EM wwu@clarkson.edu
FU Coastal Inlets Research Program (CIRP), ERDC, U.S, Army Corps of
Engineers, Vicksburg, MS, USA
FX This study is supported by the Coastal Inlets Research Program (CIRP),
ERDC, U.S, Army Corps of Engineers, Vicksburg, MS, USA. Dr. Julie D.
Rosati, Dr. Honghai Li, Mr. Mitchell Brown, Dr. Lihwa Lin, and Dr. Zeki
Demirbilek are acknowledged for their collaborations and contributions.
NR 82
TC 0
Z9 0
U1 11
U2 11
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1616-7341
EI 1616-7228
J9 OCEAN DYNAM
JI Ocean Dyn.
PD NOV
PY 2016
VL 66
IS 11
BP 1475
EP 1495
DI 10.1007/s10236-016-0994-3
PG 21
WC Oceanography
SC Oceanography
GA DY6DN
UT WOS:000385196600006
ER
PT J
AU Craig, KA
Escobar, E
Inwards, CY
Kransdorf, MJ
AF Craig, Keith A.
Escobar, Eduardo
Inwards, Carrie Y.
Kransdorf, Mark J.
TI Imaging characteristics of intravascular papillary endothelial
hyperplasia
SO SKELETAL RADIOLOGY
LA English
DT Article
DE Intravascular papillary endothelial hyperplasia; Papillary endothelial
hyperplasia; Masson lesion; Vegetant intravascular hemangioendothelioma;
Soft tissue neoplasm; Vascular lesion
ID HEMANGIOENDOTHELIOMA
AB Intravascular papillary endothelial hyperplasia (IPEH) is a soft tissue, tumor-like, benign, reactive, vascular proliferation that, although not rare, is uncommonly imaged. We report the imaging findings of intravascular papillary endothelial hyperplasia in 13 patients, highlighting characteristic imaging features.
We retrospectively reviewed 13 patients with IPEH who had corresponding MR and/or ultrasound imaging. MR imaging studies were evaluated for lesion location, shape, size, signal intensity, signal heterogeneity, and enhancement. Ultrasound studies were assessed for lesion shape, size, echogenicity, heterogeneity, and vascularity. Demographic data, including patient age, gender, and clinical history were also reviewed.
Most patients (11 of 13) presented with an enlarging mass. The age range was 10-72 years (mean 46) with ten females and three males. Eleven of the 13 lesions were primary IPEH without an associated preexisting vascular lesion. Ten of 13 lesions were in the superficial soft tissues, all of which were primary IPEH. Two of the three lesions in the deep tissues were secondary IPEH, arising within a preexisting vascular lesion. Lesions were small (mean 1.4 cm) and had a rounded shape. All of the primary lesions demonstrated high T2 signal peripherally and variable T2 signal centrally, with most demonstrating superficial location (91 %), peripheral enhancement (89 %) and associated dominant vessel (73 %). The five lesions evaluated by ultrasound were all hypoechoic with either scattered or peripheral vascularity on Doppler.
Primary papillary endothelial hyperplasia is commonly seen in the superficial soft tissues when captured on imaging and has a characteristic imaging appearance.
C1 [Craig, Keith A.; Kransdorf, Mark J.] Mayo Clin, Dept Radiol, 5777 East Mayo Blvd, Phoenix, AZ 85054 USA.
[Escobar, Eduardo] Brooke Army Med Ctr, Dept Radiol, San Antonio, TX 78234 USA.
[Inwards, Carrie Y.] Mayo Clin, Dept Anat Pathol, 200 1st St SW, Rochester, MN 55905 USA.
RP Kransdorf, MJ (reprint author), Mayo Clin, Dept Radiol, 5777 East Mayo Blvd, Phoenix, AZ 85054 USA.
EM craig.keith@mayo.edu; eduardo.escobar.mil@mail.mil;
inwards.carrie@mayo.edu; kransdorf.mark@mayo.edu
NR 12
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0364-2348
EI 1432-2161
J9 SKELETAL RADIOL
JI Skeletal Radiol.
PD NOV
PY 2016
VL 45
IS 11
BP 1467
EP 1472
DI 10.1007/s00256-016-2445-0
PG 6
WC Orthopedics; Radiology, Nuclear Medicine & Medical Imaging
SC Orthopedics; Radiology, Nuclear Medicine & Medical Imaging
GA DY5XI
UT WOS:000385177400002
PM 27538971
ER
PT J
AU Liu, JC
Jayakumar, P
Stein, JL
Ersal, T
AF Liu, Jiechao
Jayakumar, Paramsothy
Stein, Jeffrey L.
Ersal, Tulga
TI A study on model fidelity for model predictive control-based obstacle
avoidance in high-speed autonomous ground vehicles
SO VEHICLE SYSTEM DYNAMICS
LA English
DT Article
DE Collision avoidance; vehicle dynamics; model predictive control;
autonomous ground vehicles; vehicle safety
ID DYNAMIC WINDOW APPROACH; MOBILE ROBOTS; NAVIGATION; STRATEGIES
AB This paper investigates the level of model fidelity needed in order for a model predictive control (MPC)-based obstacle avoidance algorithm to be able to safely and quickly avoid obstacles even when the vehicle is close to its dynamic limits. The context of this work is large autonomous ground vehicles that manoeuvre at high speed within unknown, unstructured, flat environments and have significant vehicle dynamics-related constraints. Five different representations of vehicle dynamics models are considered: four variations of the two degrees-of-freedom (DoF) representation as lower fidelity models and a fourteen DoF representation with combined-slip Magic Formula tyre model as a higher fidelity model. It is concluded that the two DoF representation that accounts for tyre nonlinearities and longitudinal load transfer is necessary for the MPC-based obstacle avoidance algorithm in order to operate the vehicle at its limits within an environment that includes large obstacles. For less challenging environments, however, the two DoF representation with linear tyre model and constant axle loads is sufficient.
C1 [Liu, Jiechao; Stein, Jeffrey L.; Ersal, Tulga] Univ Michigan, Dept Mech Engn, Ann Arbor, MI 48109 USA.
[Jayakumar, Paramsothy] US Army RDECOM TARDEC, Warren, MI USA.
RP Ersal, T (reprint author), Univ Michigan, Dept Mech Engn, Ann Arbor, MI 48109 USA.
EM tersal@umich.edu
FU Automotive Research Center (ARC) [W56HZV-14-2-0001]
FX The authors wish to acknowledge the financial support of the Automotive
Research Center (ARC) in accordance with Cooperative Agreement
W56HZV-14-2-0001 U.S. Army Tank Automotive Research, Development and
Engineering Center (TARDEC) Warren, MI.
NR 25
TC 0
Z9 0
U1 20
U2 20
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0042-3114
EI 1744-5159
J9 VEHICLE SYST DYN
JI Veh. Syst. Dyn.
PD NOV
PY 2016
VL 54
IS 11
BP 1629
EP 1650
DI 10.1080/00423114.2016.1223863
PG 22
WC Engineering, Mechanical
SC Engineering
GA DX3GH
UT WOS:000384261100006
ER
PT J
AU Cox, B
Im, MS
AF Cox, Ben
Im, Mee Seong
TI Families of orthogonal Laurent polynomials, hyperelliptic lie algebras
and elliptic integrals
SO INTEGRAL TRANSFORMS AND SPECIAL FUNCTIONS
LA English
DT Article
DE Hyperelliptic lie algebras; Krichever-Novikov algebras; universal
central extensions; Date-Jimbo-Kashiwara-Miwa algebras; elliptic
integrals; Pell's equation; Chebyshev polynomials
ID LANDAU-LIFSHITZ EQUATION; RIEMANN BOUNDARY-PROBLEM; HOLOMORPHIC BUNDLES;
LIFSCHITZ EQUATION; TORUS
AB We describe a family of polynomials discovered via a particular recursion relation, which have connections to Chebyshev polynomials of the first and the second kind, and the polynomial version of Pell's equation. Many of their properties are listed in Section3. We show that these families of polynomials in the variable t satisfy certain second-order linear differential equations that may be of interest to mathematicians in conformal field theory and number theory. We also prove that these families of polynomials in the setting of Date-Jimbo-Kashiwara-Miwa algebras when multiplied by a suitable power of t are orthogonal with respect to explicitly described kernels. Particular cases lead to new identities of elliptic integrals (see Section5).
C1 [Cox, Ben] Coll Charleston, Dept Math, Charleston, SC 29424 USA.
[Im, Mee Seong] US Mil Acad, Dept Math Sci, West Point, NY 10996 USA.
RP Cox, B (reprint author), Coll Charleston, Dept Math, Charleston, SC 29424 USA.
EM coxbl@cofc.edu
FU Simons Collaboration Grant [319261]; NSF-AWM Mentoring Grant
FX The first author was partially supported by Simons Collaboration Grant
#319261 and the second author was supported by NSF-AWM Mentoring Grant.
NR 27
TC 0
Z9 0
U1 1
U2 1
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1065-2469
EI 1476-8291
J9 INTEGR TRANSF SPEC F
JI Integral Transform. Spec. Funct.
PD NOV
PY 2016
VL 27
IS 11
BP 899
EP 919
DI 10.1080/10652469.2016.1227979
PG 21
WC Mathematics, Applied; Mathematics
SC Mathematics
GA DX8LB
UT WOS:000384638700005
ER
PT J
AU Martin, DP
Melby, NL
Jordan, SM
Bednar, AJ
Kennedy, AJ
Negrete, ME
Chappell, MA
Poda, AR
AF Martin, David P.
Melby, Nicolas L.
Jordan, Shinita M.
Bednar, Anthony J.
Kennedy, Alan J.
Negrete, Maria E.
Chappell, Mark A.
Poda, Aimee R.
TI Nanosilver conductive ink: A case study for evaluating the potential
risk of nanotechnology under hypothetical use scenarios
SO CHEMOSPHERE
LA English
DT Article
DE Nanosilver; Release; Single particle ICP-MS; Environmental health and
safety; Hazard; Regulatory
ID ENVIRONMENTAL-IMPACT; NANOMATERIALS; TOXICITY; PRODUCTS; RELEASE;
IDENTIFICATION; NANOPARTICLES; BEHAVIOR
AB Engineered nanomaterials (ENMs) are being incorporated into a variety of consumer products due to unique properties that offer a variety of advantages over bulk materials. Understanding of the nano specific risk associated with nano-enabled technologies, however, continues to lag behind research and development, registration with regulators, and commercialization. One example of a nano-enabled technology is nanosilver ink, which can be used in commercial ink-jet printers for the development of low-cost printable electronics. This investigation utilizes a tiered EHS framework to evaluate the potential nano-specific release, exposure and hazard associated with typical use of both nanosilver ink and printed circuits. The framework guides determination of the potential for ENM release from both forms of the technology in simulated use scenarios, including spilling of the ink, aqueous release (washing) from the circuits and UV light exposure. The as-supplied ink merits nano-specific consideration based on the presence of nanoparticles and their persistence in environmentally-relevant media. The material released from the printed circuits upon aqueous exposure was characterized by a number of analysis techniques, including ultracentrifugation and single particle ICP-MS, and the results suggest that a vast majority of the material was ionic in nature and nano-specific regulatory scrutiny may be less relevant. Published by Elsevier Ltd.
C1 [Martin, David P.; Melby, Nicolas L.; Bednar, Anthony J.; Kennedy, Alan J.; Chappell, Mark A.; Poda, Aimee R.] US Army Engn Res & Dev Ctr, Vicksburg, MS 39180 USA.
[Jordan, Shinita M.; Negrete, Maria E.] HX5 LLC, Vicksburg, MS 39180 USA.
RP Martin, DP (reprint author), US Army Engn Res & Dev Ctr, Vicksburg, MS 39180 USA.
EM david.p.martin@usace.army.mil
RI Poda, Aimee/K-1905-2012
NR 36
TC 0
Z9 0
U1 28
U2 29
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0045-6535
EI 1879-1298
J9 CHEMOSPHERE
JI Chemosphere
PD NOV
PY 2016
VL 162
BP 222
EP 227
DI 10.1016/j.chemosphere.2016.07.082
PG 6
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA DV9XW
UT WOS:000383296500027
PM 27497530
ER
PT J
AU Katseanes, CK
Chappell, MA
Hopkins, BG
Durham, BD
Price, CL
Porter, BE
Miller, LF
AF Katseanes, Chelsea K.
Chappell, Mark A.
Hopkins, Bryan G.
Durham, Brian D.
Price, Cynthia L.
Porter, Beth E.
Miller, Lesley F.
TI Multivariate functions for predicting the sorption of
2,4,6-trinitrotoluene (TNT) and 1,3,5-trinitro-1,3,5-tricyclohexane
(RDX) among taxonomically distinct soils
SO JOURNAL OF ENVIRONMENTAL MANAGEMENT
LA English
DT Article
DE 2,4,6-Trinitrotoluene; 1,3,5-Trinitro-1,3,5-tricyclohexane; Soil
fertility; Multivariate dimension reduction analysis; Contaminant
environmental persistence
ID ORGANIC-MATTER; TRACE-ELEMENTS; CLAY-MINERALS; ADSORPTION; BINDING;
FATE; SYSTEM; CONSTITUENTS; NITROBENZENE; DEGRADATION
AB After nearly a century of use in numerous munition platforms, TNT and RDX contamination has turned up largely in the environment due to ammunition manufacturing or as part of releases from low-order detonations during training activities. Although the basic knowledge governing the environmental fate of TNT and RDX are known, accurate predictions of TNT and RDX persistence in soil remain elusive, particularly given the universal heterogeneity of pedomorphic soil types. In this work, we proposed a new solution for modeling the sorption and persistence of these munition constituents as multivariate mathematical functions correlating soil attribute data over a variety of taxonomically distinct soil types to contaminant behavior, instead of a single constant or parameter of a specific absolute value. To test this idea, we conducted experiments measuring the sorption of TNT and RDX on taxonomically different soil types that were extensively physical and chemically characterized. Statistical decomposition of the log-transformed, and auto-scaled soil characterization data using the dimension-reduction technique PCA (principal component analysis) revealed a strong latent structure based in the multiple pairwise correlations among the soil properties. TNT and RDX sorption partitioning coefficients (KD-TNT and KD-RDX) were regressed against this latent structure using partial least squares regression (PLSR), generating a 3-factor, multivariate linear functions. Here, PLSR models predicted KD-TNT and KD-RDX values based on attributes contributing to endogenous alkaline/calcareous and soil fertility criteria, respectively, exhibited among the different soil types: We hypothesized that the latent structure arising from the strong covariance of full multivariate geochemical matrix describing taxonomically distinguished soil types may provide the means for potentially predicting complex phenomena in soils. The development of predictive multivariate models tuned to a local soil's taxonomic designation would have direct benefit to military range managers seeking to anticipate the environmental risks of training activities on impact sites. Published by Elsevier Ltd.
C1 [Katseanes, Chelsea K.; Hopkins, Bryan G.] Brigham Young Univ, Dept Plant & Wildlife Sci, Provo, UT 84602 USA.
[Chappell, Mark A.; Durham, Brian D.; Price, Cynthia L.; Porter, Beth E.; Miller, Lesley F.] US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS USA.
RP Chappell, MA (reprint author), US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS USA.
EM mark.a.chappell@usace.army.mil
NR 49
TC 0
Z9 0
U1 8
U2 8
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 0301-4797
EI 1095-8630
J9 J ENVIRON MANAGE
JI J. Environ. Manage.
PD NOV 1
PY 2016
VL 182
BP 101
EP 110
DI 10.1016/j.jenvman.2016.07.043
PG 10
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA DV9VZ
UT WOS:000383291600011
PM 27454101
ER
PT J
AU Dietrich, J
Eder, K
Thompson, D
Buchanan, R
Skalski, J
McMichael, G
Fryer, D
Loge, F
AF Dietrich, Joseph
Eder, Kai
Thompson, Donald
Buchanan, Rebecca
Skalski, John
McMichael, Geoffrey
Fryer, Derek
Loge, Frank
TI Survival and transit of in-river and transported yearling Chinook salmon
in the lower Columbia River and estuary
SO FISHERIES RESEARCH
LA English
DT Article
DE Columbia River estuary; Salmon; Acoustic telemetry; Barge
transportation; Survival
ID INTEGRATED TRANSPONDER TAGS; JUVENILE SALMONIDS; SNAKE RIVER; DELAYED
MORTALITY; SEAWARD MIGRATION; HYDROPOWER SYSTEM; AVIAN PREDATION; PLUME
USA; STEELHEAD; RATES
AB The lower Columbia River and estuary (LRE) is a critically important environment for outmigrating salmonids, yet uncertainties remain about the survival and behavior of barged and in-river migrating fish. Although studies have used telemetry to monitor Chinook salmon movement and survival through the LRE, comparisons between outmigration years are confounded by differences in tag technologies, array locations, and experimental designs. In the present study, multiple releases of barged and in-river Snake River spring/summer Chinook salmon were implanted with acoustic tags and monitored at multiple locations between Lower Granite Dam on the Snake River (695 km from the mouth of the Columbia River) to within 3 km of the Pacific Ocean. LRE survival estimates and transit rates of barged fish significantly varied throughout the outmigration season. The transit rates of in-river fish also varied, but without a corresponding seasonal difference in LRE survival estimates. Early release groups of barged salmon were slower and had lower survival in the LRE than in-river salmon. Estuary arrival timing and the magnitude of transit rates may contribute to significant differences in LRE mortality between in-river and barged juvenile salmon. Survival in the Lower River reaches was stable and exceeded 0.90 for both barged and in-river fish, while survival decreased markedly in the Estuary. Differential distributions of arrival to the LRE, transit rates, and survival suggest that the outmigration experience is not homogenous for barged and in-river yearling Snake River Chinook salmon, and that previous outmigration experience of threatened and endangered salmon should be considered in future management decisions and recovery plans. (C) 2016 Elsevier B.V. All rights reserved.
C1 [Dietrich, Joseph] Natl Marine Fisheries Serv, Environm & Fisheries Sci Div, Northwest Fisheries Sci Ctr, NOAA, 2032 SE OSU Dr, Newport, OR 97365 USA.
[Eder, Kai; Thompson, Donald; Loge, Frank] Univ Calif Davis, Dept Civil & Environm Engn, One Shields Ave, Davis, CA 95616 USA.
[Buchanan, Rebecca; Skalski, John] Univ Washington, Sch Aquat & Fishery Sci, 1325 Fourth Ave,Suite 1820, Seattle, WA 98101 USA.
[McMichael, Geoffrey] Pacific Northwest Natl Lab, Ecol Grp, POB 999,MSK6-85, Richland, WA 99352 USA.
[Fryer, Derek] US Army Corps Engineers, 201 N 3rd Ave, Walla Walla, WA 99362 USA.
RP Loge, F (reprint author), Univ Calif Davis, Dept Civil & Environm Engn, One Shields Ave, Davis, CA 95616 USA.
EM kai.eder@csus.edu; geoff@mainstemfish.com; fjloge@ucdavis.edu
OI Skalski, John/0000-0002-7070-2505
FU US Army Corps of Engineers (USACE); Walla Walla District
[W912EF-08-D-0007]
FX This project was funded by the US Army Corps of Engineers (USACE), Walla
Walla District, Contract Number W912EF-08-D-0007, Delivery Order 1. Any
opinions, findings, and conclusions or recommendations expressed in this
material are those of the authors and do not necessarily reflect the
views of the supporting agency. Surgery training, tagging assistance at
Lower Granite Dam, collection and analysis of JSATS data, and reporting
assistance were provided by Katherine Deters, Jessica Carter, and a host
of others from the Pacific Northwest National Laboratory. Programming of
the PIT-tag separation-by-code functions was provided by Dave Marvin,
Pacific States Marine Fisheries Commission. Assistance in fish
collection and facilities were provided, in part, by Kent Blevins
(USACE), Mike Halter (USACE), Doug Marsh and Neil Paasch (National
Oceanic and Atmospheric Administration [NOAA]), Fred Mensik and Sean
Rapp (Smolt Monitoring Program) at Lower Granite Dam. Finally, thank you
to Andrew Holguin (U.C. Davis) for generating the GIS maps of our study
areas.
NR 57
TC 0
Z9 0
U1 34
U2 34
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0165-7836
EI 1872-6763
J9 FISH RES
JI Fish Res.
PD NOV
PY 2016
VL 183
BP 435
EP 446
DI 10.1016/j.fishres.2016.07.005
PG 12
WC Fisheries
SC Fisheries
GA DV0HW
UT WOS:000382599600045
ER
PT J
AU Wang, YQ
Miao, YY
Huang, LJ
Swenson, D
Yen, CF
Yu, J
Zheng, JQ
AF Wang, Youqi
Miao, Yuyang
Huang, Lejian
Swenson, Daniel
Yen, Chian-Fong
Yu, Jian
Zheng, James Q.
TI Effect of the inter-fiber friction on fiber damage propagation and
ballistic limit of 2-D woven fabrics under a fully confined boundary
condition
SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING
LA English
DT Article
DE Weibull distribution; Ballistic simulation; Textile mechanics; Digital
element analysis; Impact resistant
ID YARN PULL-OUT; MECHANICAL-PROPERTIES; ARAMID FABRICS; MICRO-GEOMETRY;
IMPACT ENERGY; STRENGTH; PERFORMANCE; SIMULATION; SCALE; SLIP
AB This paper investigates the effect of the inter-fiber friction coefficient on fabric ballistic performance. Firstly, dynamic stress responses within a fabric due to first fiber failure are analyzed. Relations between inter-fiber friction and progressive fiber failure are assessed. Then, ballistic perforation processes of Kevlar KM2 fabrics are simulated using a fiber level micro-approach, the digital element approach (DEA). In this model, each yarn is discretized into many fibers and each fiber is divided into many rod elements. A Monte Carlo process is utilized to assign a unique strength to each element following a bimodal Weibull distribution function. DEA is used to simulate the ballistic perforation processes. A comparative investigation using a broad range of inter-fiber friction coefficients are conducted. Relations of ballistic limits and inter-fiber friction coefficients are presented. Simulation results show that ballistic limit improves as the inter-fiber friction coefficient increases up to a critical value. Beyond that point, ballistic strength decreases slightly as the inter-fiber friction coefficient increases. The inter-fiber friction also changes the ballistic perforation mechanisms. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Wang, Youqi; Miao, Yuyang; Huang, Lejian; Swenson, Daniel] Kansas State Univ, Dept Mech & Nucl Engn, Manhattan, KS 66506 USA.
[Yen, Chian-Fong; Yu, Jian] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA.
[Zheng, James Q.] Program Execut Off Soldier, Ft Belvoir, Ft Belvoir, VA 20169 USA.
RP Wang, YQ (reprint author), Kansas State Univ, Dept Mech & Nucl Engn, Manhattan, KS 66506 USA.
EM Youqi@ksu.edu
FU Program Executive Office - Soldier [W911NF-12-2-0020]; U.S. Army
Research Laboratory
FX The authors would like to acknowledge the financial support from the
U.S. Army Research Laboratory and the Program Executive Office - Soldier
(W911NF-12-2-0020).
NR 35
TC 1
Z9 1
U1 18
U2 18
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0734-743X
EI 1879-3509
J9 INT J IMPACT ENG
JI Int. J. Impact Eng.
PD NOV
PY 2016
VL 97
BP 66
EP 78
DI 10.1016/j.ijimpeng.2016.06.007
PG 13
WC Engineering, Mechanical; Mechanics
SC Engineering; Mechanics
GA DU6QK
UT WOS:000382339500006
ER
PT J
AU George, J
Kaplan, LM
AF George, Jemin
Kaplan, Lance M.
TI A finite point process approach to multi-target localization using
transient measurements
SO INFORMATION FUSION
LA English
DT Article
DE Multi-sensor multi-target localization; Finite point process; Poisson
point process; Expectation maximization; Optimal subpattem assignment;
Acoustic gunfire detection
ID PROBABILISTIC DATA ASSOCIATION; MULTIPLE HYPOTHESIS TRACKING; SHOOTER
LOCALIZATION; TDOA MEASUREMENTS; DENSITY FILTER; EM ALGORITHM; PHD
FILTER; TARGETS; SENSORS; SYSTEM
AB A finite point process approach to multi-target localization from a transient signal is presented. After modeling the measurements as a Poisson point process, we propose a twofold scheme that includes an expectation maximization algorithm to estimate the target locations for a given number of targets and an information theoretic algorithm to select the number of targets. The proposed localization scheme does not require explicitly solving the data association problem and can account for clutter noise as well as missed detections. Although point process theory has been widely utilized for sequential tracking of multiple moving targets, the application of point process theory for multi-target localization from transient measurements has received very little attention. The optimal subpattern assignment metric is used to assess the performance and accuracy of the proposed localization algorithm. Implementation of the proposed algorithm on synthetic data yields desirable results. The proposed algorithm is then applied to the multi-shooter localization problem using acoustic gunfire detection systems. Published by Elsevier B.V.
C1 [George, Jemin; Kaplan, Lance M.] US Army, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
RP George, J (reprint author), US Army, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM jemin.george.civ@mail.mil; lance.m.kaplan.civ@mail.mil
NR 55
TC 0
Z9 0
U1 14
U2 27
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1566-2535
EI 1872-6305
J9 INFORM FUSION
JI Inf. Fusion
PD NOV
PY 2016
VL 32
BP 62
EP 74
DI 10.1016/j.inffus.2016.04.001
PN A
PG 13
WC Computer Science, Artificial Intelligence; Computer Science, Theory &
Methods
SC Computer Science
GA DN7BJ
UT WOS:000377230000005
ER
PT J
AU Karna, SLR
D'Arpa, P
Chen, T
Qian, LW
Fourcaudot, AB
Yamane, K
Chen, P
Abercrombie, JJ
You, T
Leung, KP
AF Karna, S. L. Rajasekhar
D'Arpa, Peter
Chen, Tsute
Qian, Li-Wu
Fourcaudot, Andrea B.
Yamane, Kazuyoshi
Chen, Ping
Abercrombie, Johnathan J.
You, Tao
Leung, Kai P.
TI RNA-Seq Transcriptomic Responses of FullThickness Dermal Excision Wounds
to Pseudomonas aeruginosa Acute and Biofilm Infection
SO PLOS ONE
LA English
DT Article
ID ALTERNATIVE SIGMA-FACTOR; GENE-EXPRESSION DATA; RABBIT-EAR; METABOLIC
STRESS; OXIDATIVE STRESS; IN-VITRO; MODEL; ACTIVATION; PVDS; REGULATORS
AB Pseudomonas aeruginosa infections of wounds in clinical settings are major complications whose outcomes are influenced by host responses that are not completely understood. Herein we evaluated transcriptomic changes of wounds as they counter P. aeruginosa infection D first active infection, and then chronic biofilm infection. We used the dermal fullthickness, rabbit ear excisional wound model. We studied the wound response: towards acute infection at 2, 6, and 24 hrs after inoculating 10(6) bacteria into day-3 wounds; and, towards more chronic biofilm infection of wounds similarly infected for 24 hrs but then treated with topical antibiotic to coerce biofilm growth and evaluated at day 5 and 9 postinfection. The wounds were analyzed for bacterial counts, expression of P. aeruginosa virulence and biofilm-synthesis genes, biofilm morphology, infiltrating immune cells, re-epithelialization, and genome-wide gene expression (RNA-Seq transcriptome). This analysis revealed that 2 hrs after bacterial inoculation into day-3 wounds, the down-regulated genes (infected vs. non-infected) of the wound edge were nearly all non-coding RNAs (ncRNAs), comprised of snoRNA, miRNA, and RNU6 pseudogenes, and their down-regulation preceded a general down-regulation of skin-enriched coding gene expression. As the active infection intensified, ncRNAs remained overrepresented among down-regulated genes; however, at 6 and 24 hrs they changed to a different set, which overlapped between these times, and excluded RNU6 pseudogenes but included snRNA components of the major and minor spliceosomes. Additionally, the raw counts of multiple types of differentiallyexpressed ncRNAs increased on post-wounding day 3 in control wounds, but infection suppressed this increase. After 5 and 9 days, these ncRNA counts in control wounds decreased, whereas they increased in the infected, healing-impaired wounds. These data suggest a sequential and coordinated change in the levels of transcripts of multiple major classes of ncRNAs in wound cells transitioning from inflammation to the proliferation phase of healing.
C1 [Karna, S. L. Rajasekhar; Qian, Li-Wu; Fourcaudot, Andrea B.; Yamane, Kazuyoshi; Chen, Ping; Abercrombie, Johnathan J.; You, Tao; Leung, Kai P.] US Army Inst Surg Res, Dent & Craniofacial Trauma Res & Tissue Regenerat, Jbsa Ft Sam Houston, TX USA.
[D'Arpa, Peter] US Army Ctr Environm Hlth Res, Ft Detrick, MD USA.
[D'Arpa, Peter] Geneva Fdn, Tacoma, WA USA.
[Chen, Tsute] Forsyth Inst, Cambridge, MA USA.
RP Leung, KP (reprint author), US Army Inst Surg Res, Dent & Craniofacial Trauma Res & Tissue Regenerat, Jbsa Ft Sam Houston, TX USA.
EM kai.p.leung.civ@mail.mil
FU US Army Medical Research and Materiel Command; Combat Casualty Care
Research Directorate; Naval Medical Research Center's Advanced Medical
Development program [MIPR N3239815MHX040]; Research Associateship
Program from the National Research Council; U. S. Army Research
Laboratory; U.S. Army Research Office [W911NF1310376]
FX This work was supported in part by the US Army Medical Research and
Materiel Command, Combat Casualty Care Research Directorate and the
Naval Medical Research Center's Advanced Medical Development program
(MIPR N3239815MHX040) (KPL)and the Research Associateship Program from
the National Research Council (SLRK). P. D'Arpa is supported by the U.
S. Army Research Laboratory and the U.S. Army Research Office under
contract/grant number W911NF1310376 to The Geneva Foundation. The
funders had no role in study design, data collection and analysis,
decision to publish, or preparation of the manuscript.
NR 51
TC 0
Z9 0
U1 6
U2 6
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD OCT 28
PY 2016
VL 11
IS 10
DI 10.1371/journal.pone.0165312
PG 21
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA EE3YA
UT WOS:000389537000017
ER
PT J
AU Kube, CM
de Jong, M
AF Kube, Christopher M.
de Jong, Maarten
TI Elastic constants of polycrystals with generally anisotropic crystals
SO JOURNAL OF APPLIED PHYSICS
LA English
DT Article
ID HASHIN-SHTRIKMAN BOUNDS; CUBIC TRANSITION-METALS; AUGMENTED-WAVE METHOD;
SINGLE-CRYSTAL; MARTENSITIC-TRANSFORMATION; TETRAGONAL SYMMETRIES;
DISORDERED MATERIALS; MODULI; PRINCIPLES; FRAMEWORK
AB A homogenization model is developed that describes the effective elastic constants of polycrystalline materials with constituent crystallites of general anisotropy (triclinic symmetry). The model is solved through an iterative technique where successive iterations improve the estimates of the polycrystal's elastic constants. Convergence of the solution provides the self-consistent elastic constants, which are the polycrystal's elastic constants resulting from continuity between local and far-field stress and strains. Iterative solutions prior to convergence are the bounds on the elastic constants including the Voigt-Reuss and Hashin-Shtrikman bounds. The second part of the article establishes a formal link between the present model and single-crystal elastic anisotropy. An analysis from a dataset containing 2176 inorganic crystalline compounds, spanning all crystallographic symmetries, is provided. The role of elastic anisotropy and related properties such as crystalline structure and elastic stability are discussed as it relates to the model. Published by AIP Publishing.
C1 [Kube, Christopher M.] US Army Res Lab, Vehicle Technol Directorate, Aberdeen Proving Ground, MD 21005 USA.
[de Jong, Maarten] Univ Calif Berkeley, Dept Mat Sci & Engn, Berkeley, CA 94720 USA.
[de Jong, Maarten] Space Explorat Technol, 1 Rocket Rd, Hawthorne, CA 90250 USA.
RP Kube, CM (reprint author), US Army Res Lab, Vehicle Technol Directorate, Aberdeen Proving Ground, MD 21005 USA.
EM christopher.m.kube.ctr@mail.mil
NR 60
TC 0
Z9 0
U1 8
U2 8
PU AMER INST PHYSICS
PI MELVILLE
PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA
SN 0021-8979
EI 1089-7550
J9 J APPL PHYS
JI J. Appl. Phys.
PD OCT 28
PY 2016
VL 120
IS 16
AR 165105
DI 10.1063/1.4965867
PG 14
WC Physics, Applied
SC Physics
GA EB7PI
UT WOS:000387580600048
ER
PT J
AU Rasmussen, TE
Kellermann, AL
AF Rasmussen, Todd E.
Kellermann, Arthur L.
TI Wartime Lessons - Shaping a National Trauma Action Plan
SO NEW ENGLAND JOURNAL OF MEDICINE
LA English
DT Editorial Material
C1 [Rasmussen, Todd E.] US Army Med Res & Mat Command, Combat Casualty Care Res Program, Ft Detrick, MD 21702 USA.
[Rasmussen, Todd E.; Kellermann, Arthur L.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
RP Rasmussen, TE (reprint author), US Army Med Res & Mat Command, Combat Casualty Care Res Program, Ft Detrick, MD 21702 USA.; Rasmussen, TE (reprint author), Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
NR 5
TC 0
Z9 0
U1 0
U2 0
PU MASSACHUSETTS MEDICAL SOC
PI WALTHAM
PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA
SN 0028-4793
EI 1533-4406
J9 NEW ENGL J MED
JI N. Engl. J. Med.
PD OCT 27
PY 2016
VL 375
IS 17
BP 1612
EP 1615
DI 10.1056/NEJMp1607636
PG 5
WC Medicine, General & Internal
SC General & Internal Medicine
GA EB2DX
UT WOS:000387168900007
PM 27783910
ER
PT J
AU O'Donovan, KJ
AF O'Donovan, Kevin J.
TI Intrinsic Axonal Growth and the Drive for Regeneration
SO FRONTIERS IN NEUROSCIENCE
LA English
DT Review
DE axon growth; neuronal regeneration; intrinsic growth; mouse models;
neuronal injury
ID SPINAL-CORD-INJURY; PERIPHERAL NERVOUS-SYSTEM; RETINAL GANGLION-CELLS;
ADULT SENSORY NEURONS; SYMPATHETIC NEURONS; MICE LACKING; IN-VIVO;
RECEPTOR GENE; CORTICOSPINAL TRACT; SIGNALING PATHWAYS
AB Following damage to the adult nervous system in conditions like stroke, spinal cord injury, or traumatic brain injury, many neurons die and most of the remaining spared neurons fail to regenerate. Injured neurons fail to regrow both because of the inhibitory milieu in which they reside as well as a loss of the intrinsic growth capacity of the neurons. If we are to develop effective therapeutic interventions that promote functional recovery for the devastating injuries described above, we must not only better understand the molecular mechanisms of developmental axonal growth in hopes of re-activating these pathways in the adult, but at the same time be aware that re-activation of adult axonal growth may proceed via distinct mechanisms. With this knowledge in hand, promoting adult regeneration of central nervous system neurons can become a more tractable and realistic therapeutic endeavor.
C1 [O'Donovan, Kevin J.] US Mil Acad, Dept Chem & Life Sci, West Point, NY 10996 USA.
RP O'Donovan, KJ (reprint author), US Mil Acad, Dept Chem & Life Sci, West Point, NY 10996 USA.
EM kevin.odonovan@usma.edu
FU Army Research Laboratory Collaborative Research Program; United States
Military Academy Faculty Development Research Funds
FX The author is funded by the Army Research Laboratory Collaborative
Research Program and United States Military Academy Faculty Development
Research Funds.
NR 111
TC 0
Z9 0
U1 7
U2 7
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015,
SWITZERLAND
SN 1662-453X
J9 FRONT NEUROSCI-SWITZ
JI Front. Neurosci.
PD OCT 27
PY 2016
VL 10
AR 486
DI 10.3389/fnins.2016.00486
PG 11
WC Neurosciences
SC Neurosciences & Neurology
GA EA0RB
UT WOS:000386293700001
PM 27833527
ER
PT J
AU Strawhecker, KE
Sandoz-Rosado, EJ
Stockdale, TA
Laird, ED
AF Strawhecker, Kenneth E.
Sandoz-Rosado, Emil J.
Stockdale, Taylor A.
Laird, Eric D.
TI Interior morphology of high-performance polyethylene fibers revealed by
modulus mapping
SO POLYMER
LA English
DT Article
DE Ultra-high-molecular-weight polyethylene; AFM; Modulus mapping; Interior
structure; Morphology; Fiber drawing; Extended chain; Epitaxial
crystallization; Shish-kebab; Voids
ID MOLECULAR-WEIGHT POLYETHYLENE; X-RAY-DIFFRACTION; FORCE MICROSCOPY;
MECHANICAL-PROPERTIES; DOMAIN SIZES; PHASE; NMR; TEMPERATURE;
TRANSFORMATION; TRANSITION
AB This work elucidates the undisturbed interior morphology of commercial ultra-high-molecular-weight polyethylene (UHMWPE) high-performance fibers through atomic force microscopy (AFM) modulus mapping of interior surfaces exposed by a novel focused ion beam (FIB)-notched sample preparation technique. The imaging shows unequivocally the presence of epitaxial crystals in the interior of highly drawn UHMWPE fibers. Overall, AFM observations and measurements were made for three different commercial fiber types, illustrating five basic UHMWPE morphologies: (i) extended chain fibrils (shish), (ii) interlocking and (iii) standalone kebab or epitaxial crystals, (iv) voids or interface between fibrils, and (v) tie chains across voids. Furthermore, microfibrils were bundled into groups separated by voids or amorphous material. Bundled groups of microfibrils group together to form macrofibrils, typically separated by larger voids or amorphous material. Additionally, stretched tie-chain bridges provide connectivity between some fibrils. Each of these five features (extended chain fibrils, interlocking and standalone epitaxial crystals, voids and tie-chains) varies across the three types of commercial fibers, and sometimes across the individual fiber interiors. AFM contact modulus values measured transverse to the fiber draw axis were found to vary considerably within different morphological domains. The distribution of morphology sizing was quantified for each of the examined fibers. The measurement of internal facets have major implications for fiber modeling and processing, such as optimization of draw ratios to affect the extent and arrangement of epitaxial crystalline morphologies and thus improve mechanical performance. Published by Elsevier Ltd.
C1 [Strawhecker, Kenneth E.; Sandoz-Rosado, Emil J.; Laird, Eric D.] US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
[Stockdale, Taylor A.] Univ Nebraska Lincoln, Dept Mech & Mat Engn, Lincoln, NE 68588 USA.
RP Strawhecker, KE (reprint author), US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
EM kenneth.e.strawhecker.civ@mail.mil
FU Academy of Applied Science [W911SR-15-2-0001]
FX The authors acknowledge E.D. Wetzel for direction. K.S. would like to
acknowledge A. Labuda, P. McDaniel, and S. Lustig for insightful
discussion. T.S. acknowledges Army Educational Outreach Program which is
administered by the Academy of Applied Science, contract
W911SR-15-2-0001.
NR 39
TC 0
Z9 0
U1 9
U2 9
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0032-3861
EI 1873-2291
J9 POLYMER
JI Polymer
PD OCT 26
PY 2016
VL 103
BP 224
EP 232
DI 10.1016/j.polymer.2016.09.062
PG 9
WC Polymer Science
SC Polymer Science
GA DY9XO
UT WOS:000385489900027
ER
PT J
AU Masser, KA
Bain, ED
Beyer, FL
Savage, AM
Yu, JH
Lenhart, JL
AF Masser, Kevin A.
Bain, Erich D.
Beyer, Frederick L.
Savage, Alice M.
Yu, Jian H.
Lenhart, Joseph L.
TI Influence of nano-scale morphology on impact toughness of epoxy blends
SO POLYMER
LA English
DT Article
DE Polymer network; Ballistic performance; Nanoscale heterogeneity
ID INDUCED PHASE-SEPARATION; MOLECULAR-DYNAMICS SIMULATION;
RUBBER-TOUGHENED EPOXY; POLYMER BLENDS; FILLED EPOXY; NANOCOMPOSITES;
TEMPERATURES; PARTICLES; STANDARD; RESINS
AB The microstructure and ballistic impact toughness was investigated for a series of dynamically heterogeneous epoxy blends composed of diglycidyl ether of bisphenol A (DGEBA) that is cross-linked with stoichiometric mixtures of a rigid cycloaliphatic diamine and flexible polypropylene oxide based di-amines. The ballistic impact resistance of the blends correlates with the presence of nano-scale structure, where blends that contain 2-5 nm domains exhibit nearly a doubling of impact toughness when compared to blends that exhibit large scale phase separation. The length scale of phase separation was manipulated by controlling the ratio of short chain to long chain propylene oxide diamines. At low long chain content, the materials nanoscale phase separate into 2-5 nm domains, resulting in a transparent epoxy that exhibits relatively good impact toughness. At high long chain volume fractions, the mixtures undergo macroscale phase separation and lose both optical clarity and impact performance. Interestingly, some of the macro-phase separated blends with intermediate long chain polypropylene oxide diamine content still exhibit high impact resistance if a nanoscale structure is still present in the rigid continuous phase. Small-angle X-ray scattering (SAXS) and transmission electron microscopy (TEM) were used to characterize the phase separated structure in these blends. When the SAXS peak associated with nanoscale phase separation shifts to lower scattering vector and its intensity is reduced, the impact performance of the mixtures is likewise reduced. We hypothesize that the small scale structure in the blends facilitates rapid deformation during high rate ballistic impact events, which allows the material to absorb more energy before failure. Published by Elsevier Ltd.
C1 [Masser, Kevin A.; Bain, Erich D.; Beyer, Frederick L.; Savage, Alice M.; Yu, Jian H.; Lenhart, Joseph L.] US Army, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA.
RP Lenhart, JL (reprint author), US Army, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA.
EM joseph.l.lenhart.civ@mail.mil
FU U.S. Department of Energy; USARL
FX This research was supported in part by an appointment to the
Postgraduate Research Participation Program at the U.S. Army Research
Laboratory administered by the Oak Ridge Institute for Science and
Education through an interagency agreement between the U.S. Department
of Energy and USARL.
NR 34
TC 0
Z9 0
U1 33
U2 33
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0032-3861
EI 1873-2291
J9 POLYMER
JI Polymer
PD OCT 26
PY 2016
VL 103
BP 337
EP 346
DI 10.1016/j.polymer.2016.09.076
PG 10
WC Polymer Science
SC Polymer Science
GA DY9XO
UT WOS:000385489900038
ER
PT J
AU Zhao, ST
Kad, B
Remington, BA
LaSalvia, JC
Wehrenberg, CE
Behler, KD
Meyers, MA
AF Zhao, Shiteng
Kad, Bimal
Remington, Bruce A.
LaSalvia, Jerry C.
Wehrenberg, Christopher E.
Behler, Kristopher D.
Meyers, Marc A.
TI Directional amorphization of boron carbide subjected to laser shock
compression
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
AMERICA
LA English
DT Article
DE lasers; shock wave; amorphization; boron carbide
ID RAMAN-SPECTROSCOPY; PRESSURE; SILICON; SOLIDS; B4C
AB Solid-state shock-wave propagation is strongly nonequilibrium in nature and hence rate dependent. Using high-power pulsed-laser-driven shock compression, unprecedented high strain rates can be achieved; here we report the directional amorphization in boron carbide polycrystals. At a shock pressure of 45 similar to 50 GPa, multiple planar faults, slightly deviated from maximum shear direction, occur a few hundred nanometers below the shock surface. High-resolution transmission electron microscopy reveals that these planar faults are precursors of directional amorphization. It is proposed that the shear stresses cause the amorphization and that pressure assists the process by ensuring the integrity of the specimen. Thermal energy conversion calculations including heat transfer suggest that amorphization is a solid-state process. Such a phenomenon has significant effect on the ballistic performance of B4C.
C1 [Zhao, Shiteng; Kad, Bimal; Meyers, Marc A.] Univ Calif San Diego, La Jolla, CA 92093 USA.
[Remington, Bruce A.; Wehrenberg, Christopher E.] Lawrence Livermore Natl Lab, Livermore, CA 94550 USA.
[LaSalvia, Jerry C.; Behler, Kristopher D.] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RP Meyers, MA (reprint author), Univ Calif San Diego, La Jolla, CA 92093 USA.
EM mameyers@eng.ucsd.edu
FU Office of Basic Energy Science, US Department of Energy; University of
California Research Laboratories Grant [09-LR-06-118456-MEYM]; National
Laser Users Facility Grant [PE-FG52-09NA-29043]
FX The enthusiastic help by Dorothy Coffey and Karren More is gratefully
acknowledged. We acknowledge the highly professional support team of the
Jupiter Laser Facility at Lawrence Livermore National Laboratory.
Electron microscopy was conducted at Center for Nanophase Materials
Sciences (CNMS) User Facility, Oak Ridge National Laboratory, which is
sponsored by the Office of Basic Energy Science, US Department of
Energy. This research is funded by University of California Research
Laboratories Grant 09-LR-06-118456-MEYM and National Laser Users
Facility Grant PE-FG52-09NA-29043.
NR 37
TC 1
Z9 1
U1 7
U2 7
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD OCT 25
PY 2016
VL 113
IS 43
BP 12088
EP 12093
DI 10.1073/pnas.1604613113
PG 6
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA DZ7ZI
UT WOS:000386087100046
PM 27733513
ER
PT J
AU Ozsdolay, BD
Mulligan, CP
Balasubramanian, K
Huang, LP
Khare, SV
Gall, D
AF Ozsdolay, B. D.
Mulligan, C. P.
Balasubramanian, K.
Huang, Liping
Khare, S. V.
Gall, D.
TI Cubic beta-WNx layers: Growth and properties vs N-to-W ratio
SO SURFACE & COATINGS TECHNOLOGY
LA English
DT Article
DE Tungsten nitride; Cubic; Nitrogen vacancy; Hardness; Density functional
calculations; Lattice constant
ID TUNGSTEN-NITRIDE FILMS; ELECTRONIC TRANSPORT-PROPERTIES; PULSED-LASER
DEPOSITION; THIN-FILMS; MECHANICAL-PROPERTIES; ELECTRICAL-RESISTIVITY;
PHYSICAL-PROPERTIES; HARD COATINGS; LOW-ENERGY; MOLYBDENUM-NITRIDE
AB Tungsten nitride layers, 1.45-mu m-thick, were deposited by reactive magnetron sputtering on MgO(001), MgO(111), and Al2O3(0001) in 20 mTorr N-2 at T-s = 500-800 degrees C. All layers deposited at T-s = 500-700 degrees C form a cubic phase, as determined by X-ray diffraction omega-2 theta scans, and show an N-to-W ratio x that decreases from x = 1.21 to 0.83 with increasing T-s = 500-700 degrees C, as measured by energy dispersive and photoelectron spectroscopies. T-s = 500 and 600 degrees C yields polycrystalline predominantly 111 oriented beta-WN on all substrates. In contrast, deposition at 700 degrees C results in epitaxial growth of beta-WN(111) and beta-WN(001) on MgO(111) and MgO(001), respectively, and a 111-preferred orientation on Al2O3(0001). T-s = 800 degrees C causes nitrogen loss and WNx layers with primarily BCC W grains and x = 0.04-0.06. Density functional theory calculations indicate an increase in structural stability by the introduction of either W or N vacancies into the cubic rock-salt structure, reducing the formation energy per atom from 0.32 eV for the rock-salt structure to 0.09 eV for WN0.75 and -0.07 eV for WN1.33, and to -0.42 eV for stoichiometric WN in the NbO structure. The out-of-plane lattice constant decreases from 4357-4.169 A with increasing T-s = 500-700 degrees C. Comparing these values with calculated lattice constants indicates that the W vacancy concentration increases from 6-11% for T-s = 500-600 degrees C to 11-18% for T-s = 700 degrees C, while the N vacancy concentration also increases from negligible to 18-29%. The simultaneous increase of both vacancy types is attributed to thermally activated N-2 recombination and desorption and atomic rearrangement towards the thermodynamically favorable cubic NbO structure which contains 25% of both W and N vacancies. The measured elastic modulus ranges from 110 to 260 GPa for 500-700 degrees C and decreases with increasing N-content, and increases to 350 GPa for T-s = 800 degrees C. The room temperature resistivity decreases with increasing T-s = 500-700 degrees C from 4.5-1.1 x 10(3) mu Omega-cm, indicating a resistivity decrease with decreasing nitrogen content and increasing crystalline quality and phase purity. (C) 2016 Elsevier B.V. All rights reserved.
C1 [Ozsdolay, B. D.; Balasubramanian, K.; Huang, Liping; Gall, D.] Rensselaer Polytech Inst, Dept Mat Sci & Engn, Troy, NY 12180 USA.
[Mulligan, C. P.] US Army, Armament Res Dev & Engn Ctr, Benet Labs, Watervliet, NY 12189 USA.
[Khare, S. V.] Univ Toledo, Dept Phys & Astron, 2801 West Bancroft St, Toledo, OH 43606 USA.
RP Gall, D (reprint author), Rensselaer Polytech Inst, Dept Mat Sci & Engn, Troy, NY 12180 USA.
EM galld@rpi.edu
RI Gall, Daniel/B-1060-2008
OI Gall, Daniel/0000-0002-5762-9307
FU National Science Foundation [1309490, 1234777, 1234872, 1537984,
1629230]
FX The authors acknowledge support by the National Science Foundation under
Grant Nos. 1309490, 1234777, 1234872, 1537984, and 1629230.
Computational resources were provided by the Center for Computational
Innovations at RPI.
NR 76
TC 1
Z9 1
U1 15
U2 15
PU ELSEVIER SCIENCE SA
PI LAUSANNE
PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND
SN 0257-8972
J9 SURF COAT TECH
JI Surf. Coat. Technol.
PD OCT 25
PY 2016
VL 304
BP 98
EP 107
DI 10.1016/j.surfcoat.2016.06.079
PG 10
WC Materials Science, Coatings & Films; Physics, Applied
SC Materials Science; Physics
GA DY0GS
UT WOS:000384775900013
ER
PT J
AU Chauhan, J
Cardinale, S
Fang, L
Huang, J
Kwasny, SM
Pennington, MR
Basi, K
diTargiani, R
Capacio, BR
MacKerell, AD
Opperman, TJ
Fletcher, S
de Leeuw, EPH
AF Chauhan, Jamal
Cardinale, Steven
Fang, Lei
Huang, Jing
Kwasny, Steven M.
Pennington, M. Ross
Basi, Kelly
diTargiani, Robert
Capacio, Benedict R.
MacKerell, Alexander D., Jr.
Opperman, Timothy J.
Fletcher, Steven
de Leeuw, Erik P. H.
TI Towards Development of Small Molecule Lipid II Inhibitors as Novel
Antibiotics
SO PLoS One
LA English
DT Article
ID GENERAL FORCE-FIELD; RESISTANT STAPHYLOCOCCUS-AUREUS;
PEPTIDOGLYCAN-BIOSYNTHESIS; FUNGAL DEFENSIN; CHARMM; INFECTIONS;
TARGETS; ENTEROCOCCUS; ORITAVANCIN; AUTOMATION
AB Recently we described a novel di-benzene-pyrylium-indolene (BAS00127538) inhibitor of Lipid II. BAS00127538 (1-Methyl-2,4-diphenyl-6-((1E, 3E)-3-(1,3,3-trimethylindolin-2-ylidene) prop-1-en-1-yl) pyryl-1-ium) tetrafluoroborate is the first small molecule Lipid II inhibitor and is structurally distinct from natural agents that bind Lipid II, such as vancomycin. Here, we describe the synthesis and biological evaluation of 50 new analogs of BAS001 27538 designed to explore the structure-activity relationships of the scaffold. The results of this study indicate an activity map of the scaffold, identifying regions that are critical to cytotoxicity, Lipid II binding and range of anti-bacterial action. One compound, 6jc48-1, showed significantly enhanced drug-like properties compared to BAS00127538. 6jc48-1 has reduced cytotoxicity, while retaining specific Lipid II binding and activity against Enterococcus spp. in vitro and in vivo. Further, this compound showed a markedly improved pharmacokinetic profile with a half-life of over 13 hours upon intravenous and oral administration and was stable in plasma. These results suggest that scaffolds like that of 6jc48-1 can be developed into small molecule antibiotic drugs that target Lipid II.
C1 [Chauhan, Jamal; Fang, Lei; Huang, Jing; MacKerell, Alexander D., Jr.; Fletcher, Steven] Univ Maryland, Sch Pharm, Dept Pharmaceut Sci, Baltimore, MD 21201 USA.
[Fang, Lei; Huang, Jing; MacKerell, Alexander D., Jr.] Univ Maryland, Sch Pharm, Comp Aided Drug Design Ctr, Baltimore, MD 21201 USA.
[Chauhan, Jamal; Fang, Lei] Univ Maryland, Sch Med, Ctr Biomol Therapeut, Baltimore, MD 21201 USA.
[Cardinale, Steven; Kwasny, Steven M.; Opperman, Timothy J.] Microbiotix Inc, One Innovat Dr, Worcester, MA USA.
[Pennington, M. Ross; Basi, Kelly; diTargiani, Robert; Capacio, Benedict R.] US Army Med Res Inst Chem Def, Aberdeen Proving Ground, MD USA.
[de Leeuw, Erik P. H.] Univ Maryland, Inst Human Virol, Baltimore Sch Med, Baltimore, MD 21201 USA.
[de Leeuw, Erik P. H.] Univ Maryland, Dept Biochem & Mol Biol, Baltimore Sch Med, Baltimore, MD 21201 USA.
RP de Leeuw, EPH (reprint author), Univ Maryland, Inst Human Virol, Baltimore Sch Med, Baltimore, MD 21201 USA.; de Leeuw, EPH (reprint author), Univ Maryland, Dept Biochem & Mol Biol, Baltimore Sch Med, Baltimore, MD 21201 USA.
EM edeleeuw@som.umaryland.edu
RI Huang, Jing/G-5320-2011
OI Huang, Jing/0000-0001-9639-2907
FU NIH [A1092033]; CBT [PR155EDL1]; Maryland Innovation Initiative; UM
Ventures seed grant; University of Maryland Computer Aided Drug Design
Center and School of Pharmacy
FX This work was supported by NIH grant A1092033 (www.nih.gov), CBT grant
PR155EDL1 (www.medschool.umaryland.edu/cbt/), a Maryland Innovation
Initiative
(http://tedco.md/program/the-maryland-innovation-initiative-mii/) award
and a UM Ventures seed grant (www.umventures.org) to EdL. Further
support was provided through the University of Maryland Computer Aided
Drug Design Center and School of Pharmacy. The funders had no role in
study design, data collection and analysis, or preparation of the
manuscript. Microbiotix Inc. provided support in the form of salaries
for authors [SC, SK and TO], but did not have any additional role in the
study design, data collection and analysis, decision to publish or
preparation of the manuscript.
NR 42
TC 0
Z9 0
U1 5
U2 5
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD OCT 24
PY 2016
VL 11
IS 10
AR e0164515
DI 10.1371/journal.pone.0164515
PG 19
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA ED7AX
UT WOS:000389009200012
PM 27776124
ER
PT J
AU Emmer, KL
Wieczorek, L
Tuyishime, S
Molnar, S
Polonis, VR
Ertl, HCJ
AF Emmer, Kristel L.
Wieczorek, Lindsay
Tuyishime, Steven
Molnar, Sebastian
Polonis, Victoria R.
Ertl, Hildegund C. J.
TI Antibody responses to prime-boost vaccination with an HIV-1 gp145
envelope protein and chimpanzee adenovirus vectors expressing HIV-1
gp140
SO AIDS
LA English
DT Article
DE adenovirus vector; antibodies; envelope proteins; HIV-1; neutralization;
vaccine
ID TEST-OF-CONCEPT; NEUTRALIZING ANTIBODY; DOUBLE-BLIND; IMMUNE-RESPONSES;
PASSIVE TRANSFER; SIV CHALLENGES; RHESUS-MONKEYS; EFFICACY TRIAL;
INFECTION; VACCINES
AB Objectives:Over 2 million individuals are infected with HIV type 1 (HIV-1) each year, yet an effective vaccine remains elusive. The most successful HIV-1 vaccine to date demonstrated 31% efficacy. Immune correlate analyses associated HIV-1 envelope (Env)-specific antibodies with protection, thus providing a path toward a more effective vaccine. We sought to test the antibody response from novel prime-boost vaccination with a chimpanzee-derived adenovirus (AdC) vector expressing a subtype C Env glycoprotein (gp)140 combined with either a serologically distinct AdC vector expressing gp140 of a different subtype C isolate or an alum-adjuvanted, partially trimeric gp145 from yet another subtype C isolate.Design:Three different prime-boost regimens were tested in mice: AdC prime-protein boost, protein prime-AdC boost, and AdC prime-AdC boost. Each regimen was tested at two different doses of AdC vector in a total of six experimental groups.Methods:Sera were collected at various time points and evaluated by ELISA for Env-specific antibody binding, isotype, and avidity. Antibody functionality was assessed by pseudovirus neutralization assay.Results:Priming with AdC followed by a protein boost or sequential immunizations with two AdC vectors induced HIV-1 Env-specific binding antibodies, including those to the variable region 2, whereas priming with protein followed by an AdC boost was relatively ineffective. Antibodies that cross-neutralized tier 1 HIV-1 from different subtypes were elicited with vaccine regimens that included immunizations with protein.Conclusion:Our study warrants further investigation of AdC vector and gp145 protein prime-boost vaccines and their ability to protect against acquisition in animal challenge studies.
C1 [Emmer, Kristel L.; Tuyishime, Steven] Univ Penn, Philadelphia, PA 19104 USA.
[Emmer, Kristel L.; Tuyishime, Steven; Ertl, Hildegund C. J.] Wistar Inst Anat & Biol, 3601 Spruce St, Philadelphia, PA 19104 USA.
[Wieczorek, Lindsay; Molnar, Sebastian; Polonis, Victoria R.] Henry M Jackson Fdn, Rockville, MD USA.
[Wieczorek, Lindsay] Mil HIV Res Program, Silver Spring, MD USA.
[Molnar, Sebastian; Polonis, Victoria R.] Walter Reed Army Inst Res, Silver Spring, MD USA.
RP Ertl, HCJ (reprint author), Wistar Inst Anat & Biol, 3601 Spruce St, Philadelphia, PA 19104 USA.
EM ertl@wistar.org
FU NIH NIAID [5 U19 AI074078-05]; Henry M. Jackson Foundation for the
Advancement of Military Medicine, Inc. [W81XWH-11-2-0174]; U.S.
Department of Defense (DOD) [W81XWH-11-2-0174]
FX This work was supported by a grant from the NIH NIAID (5 U19
AI074078-05) by H.C.J.E. This work was also supported by a cooperative
agreement (W81XWH-11-2-0174) between the Henry M. Jackson Foundation for
the Advancement of Military Medicine, Inc., and the U.S. Department of
Defense (DOD) by V.R.P.
NR 37
TC 0
Z9 0
U1 1
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0269-9370
EI 1473-5571
J9 AIDS
JI Aids
PD OCT 23
PY 2016
VL 30
IS 16
BP 2405
EP 2414
DI 10.1097/QAD.0000000000001224
PG 10
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA DZ0KV
UT WOS:000385528600002
PM 27525550
ER
PT J
AU Wec, AZ
Nyakatura, EK
Herbert, AS
Howell, KA
Holtsberg, FW
Bakken, RR
Mittler, E
Christin, JR
Shulenin, S
Jangra, RK
Bharrhan, S
Kuehne, AI
Bornholdt, ZA
Flyak, AI
Saphire, EO
Crowe, JE
Aman, MJ
Dye, JM
Lai, JR
Chandran, K
AF Wec, Anna Z.
Nyakatura, Elisabeth K.
Herbert, Andrew S.
Howell, Katie A.
Holtsberg, Frederick W.
Bakken, Russell R.
Mittler, Eva
Christin, John R.
Shulenin, Sergey
Jangra, Rohit K.
Bharrhan, Sushma
Kuehne, Ana I.
Bornholdt, Zachary A.
Flyak, Andrew I.
Saphire, Erica Ollmann
Crowe, James E., Jr.
Aman, M. Javad
Dye, John M.
Lai, Jonathan R.
Chandran, Kartik
TI A "Trojan horse" bispecific-antibody strategy for broad protection
against ebolaviruses
SO SCIENCE
LA English
DT Article
ID NIEMANN-PICK C1; VIRUS ENTRY REQUIRES; EBOLA-VIRUS; PAN-EBOLAVIRUS;
MARBURG VIRUS; SUDAN VIRUSES; GLYCOPROTEIN; RECEPTOR; INFECTION; DISEASE
AB The proteasome generates the epitopes presented on human leukocyte antigen (HLA) class I molecules that elicit CD8(+) T cell responses. Reports of proteasome-generated spliced epitopes exist, but they have been regarded as rare events. Here, however, we show that the proteasome-generated spliced peptide pool accounts for one-third of the entire HLA class I immunopeptidome in terms of diversity and one-fourth in terms of abundance. This pool also represents a unique set of antigens, possessing particular and distinguishing features. We validated this observation using a range of complementary experimental and bioinformatics approaches, as well as multiple cell types. The widespread appearance and abundance of proteasome-catalyzed peptide splicing events has implications for immunobiology and autoimmunity theories and may provide a previously untapped source of epitopes for use in vaccines and cancer immunotherapy.
C1 [Wec, Anna Z.; Mittler, Eva; Jangra, Rohit K.; Bharrhan, Sushma; Chandran, Kartik] Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10461 USA.
[Nyakatura, Elisabeth K.; Lai, Jonathan R.] Albert Einstein Coll Med, Dept Biochem, Bronx, NY 10461 USA.
[Herbert, Andrew S.; Bakken, Russell R.; Kuehne, Ana I.; Dye, John M.] US Army Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
[Howell, Katie A.; Holtsberg, Frederick W.; Shulenin, Sergey; Aman, M. Javad] Integrated Biotherapeut Inc, Gaithersburg, MD 20878 USA.
[Christin, John R.] Albert Einstein Coll Med, Dept Cell Biol, Bronx, NY 10461 USA.
[Bornholdt, Zachary A.; Saphire, Erica Ollmann] Scripps Res Inst, Dept Immunol & Microbial Sci, La Jolla, CA 10550 USA.
[Flyak, Andrew I.; Crowe, James E., Jr.] Vanderbilt Univ, Dept Pathol Microbiol & Immunol, 221 Kirkland Hall, Nashville, TN 37235 USA.
[Saphire, Erica Ollmann] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 10550 USA.
[Crowe, James E., Jr.] Vanderbilt Univ, Dept Pediat, Nashville, TN 37232 USA.
[Crowe, James E., Jr.] Vanderbilt Univ, Vanderbilt Vaccine Ctr, Nashville, TN 37232 USA.
RP Chandran, K (reprint author), Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10461 USA.; Lai, JR (reprint author), Albert Einstein Coll Med, Dept Biochem, Bronx, NY 10461 USA.; Dye, JM (reprint author), US Army Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.; Aman, MJ (reprint author), Integrated Biotherapeut Inc, Gaithersburg, MD 20878 USA.; Crowe, JE (reprint author), Vanderbilt Univ, Dept Pathol Microbiol & Immunol, 221 Kirkland Hall, Nashville, TN 37235 USA.; Crowe, JE (reprint author), Vanderbilt Univ, Dept Pediat, Nashville, TN 37232 USA.; Crowe, JE (reprint author), Vanderbilt Univ, Vanderbilt Vaccine Ctr, Nashville, TN 37232 USA.
EM james.crowe@vanderbilt.edu; javad@integratedbiotherapeutics.com;
john.m.dye1.civ@mail.mil; jon.lai@einstein.yu.edu;
kartik.chandran@einstein.yu.edu
OI Flyak, Andrew/0000-0002-8722-479X
FU NIH [U19 AI109762, R01 AI088027, 1R41 AI122403]; Joint Science and
Technology Office-Defense Threat Reduction Agency (JSTO-DTRA) project
[CB04088]; DTRA contract [HDTRA1-13-C-0015]; DAAD (Deutscher
Akademischer Austauschdienst, German Academic Exchange Service)
fellowship
FX The data presented in this manuscript are tabulated in the main paper
and in the supplementary materials. We thank C. Harold and T. Alkutkar
for technical support. We acknowledge M. D. Scharff, S. Buhl, and the
Einstein Macromolecular Therapeutics Development Facility for assistance
with generation of mAb-548; E. Ndungo for assistance with hybridoma
screening and for provision of purified human-Russell's viper NPC1
chimeras; E. L. Snapp and L. Costantini for generating an NPC1-eBFP2
fusion construct; and A. F. Labrijn, P. W. H. I. Parren, and Genmab for
the gift of purified b12*MR72 DuoBody. This work is supported by NIH
grants U19 AI109762 (Centers for Excellence in Translational Research)
to K.C., J.R.L., J.M.D., and E.O.S.; R01 AI088027 to K.C.; and 1R41
AI122403 to J.R.L. and M.J.A.; Joint Science and Technology
Office-Defense Threat Reduction Agency (JSTO-DTRA) project CB04088 to
J.M.D.; and a DTRA contract (HDTRA1-13-C-0015) to M.J.A. E.K.N. was also
supported by a DAAD (Deutscher Akademischer Austauschdienst, German
Academic Exchange Service) fellowship. M.J.A. is president of and owns
stocks, and F. W. H. and S. S. own stock options, in Integrated
Biotherapeutics. M.J.A., F.W.H., K.A.H., and S.S. are named coinventors
on a patent application (WO 2015/200522 A2) submitted by Integrated
Biotherapeutics, that covers the endosomal targeting of filovirus
bispecific antibodies. A.Z.W., E.K.N., J.R.L., and K.C. are named
coinventors on a patent application (PCT/US/16/30652) submitted by
Albert Einstein College of Medicine that covers the use of mAb-548 and
bispecific antibodies incorporating mAb-548. A.I.F. and J.E.C. are named
coinventors on a patent application (PCT/US2016/019644) submitted by
Vanderbilt University Medical Center that covers the use of the MR72
antibody and bispecific antibodies incorporating MR72. mAb-548 and
bispecific antibodies incorporating it are available from K.C. under a
material transfer agreement with Albert Einstein College of Medicine.
MR72 antibody and bispecific antibodies incorporating it are available
from J. E. C. under a material transfer agreement with Vanderbilt
University Medical Center.
NR 35
TC 1
Z9 1
U1 10
U2 10
PU AMER ASSOC ADVANCEMENT SCIENCE
PI WASHINGTON
PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA
SN 0036-8075
EI 1095-9203
J9 SCIENCE
JI Science
PD OCT 21
PY 2016
VL 354
IS 6310
BP 350
EP 354
DI 10.1126/science.aag3267
PG 7
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA EC0GN
UT WOS:000387777100051
PM 27608667
ER
PT J
AU Chaorattanakawee, S
Lon, C
Jongsakul, K
Gawee, J
Sok, S
Sundrakes, S
Kong, N
Thamnurak, C
Chann, S
Chattrakarn, S
Praditpol, C
Buathong, N
Uthaimongkol, N
Smith, P
Sirisopana, N
Huy, R
Prom, S
Fukuda, MM
Bethell, D
Walsh, DS
Lanteri, C
Saunders, D
AF Chaorattanakawee, Suwanna
Lon, Chanthap
Jongsakul, Krisada
Gawee, Jariyanart
Sok, Somethy
Sundrakes, Siratchana
Kong, Nareth
Thamnurak, Chatchadaporn
Chann, Soklyda
Chattrakarn, Sorayut
Praditpol, Chantida
Buathong, Nillawan
Uthaimongkol, Nichapat
Smith, Philip
Sirisopana, Narongrid
Huy, Rekol
Prom, Satharath
Fukuda, Mark M.
Bethell, Delia
Walsh, Douglas S.
Lanteri, Charlotte
Saunders, David
TI Ex vivo piperaquine resistance developed rapidly in Plasmodium
falciparum isolates in northern Cambodia compared to Thailand
SO MALARIA JOURNAL
LA English
DT Article
DE Malaria; Drug resistance; Piperaquine; Mefloquine; Cambodia; Thailand
ID DIHYDROARTEMISININ-PIPERAQUINE; IN-VITRO; UNCOMPLICATED FALCIPARUM;
WESTERN CAMBODIA; POPULATION PHARMACOKINETICS; ARTEMISININ RESISTANCE;
ATOVAQUONE-PROGUANIL; MALARIA; COMBINATION; CHILDREN
AB Background: The recent dramatic decline in dihydroartemisinin-piperaquine (DHA-PPQ) efficacy in northwestern Cambodia has raised concerns about the rapid spread of piperaquine resistance just as DHA-PPQ is being introduced as first-line therapy in neighbouring countries.
Methods: Ex vivo parasite susceptibilities were tracked to determine the rate of progression of DHA, PPQ and mefloquine (MQ) resistance from sentinel sites on the Thai-Cambodian and Thai-Myanmar borders from 2010 to 2015. Immediate ex vivo (IEV) histidine-rich protein 2 (HRP-2) assays were used on fresh patient Plasmodium falciparum isolates to determine drug susceptibility profiles.
Results: IEV HRP-2 assays detected the precipitous emergence of PPQ resistance in Cambodia beginning in 2013 when 40 % of isolates had an IC90 greater than the upper limit of prior years, and this rate doubled to 80 % by 2015. In contrast, Thai-Myanmar isolates from 2013 to 14 remained PPQ-sensitive, while northeastern Thai isolates appeared to have an intermediate resistance profile. The opposite trend was observed for MQ where Cambodian isolates appeared to have a modest increase in overall sensitivity during the same period, with IC50 declining to median levels comparable to those found in Thailand. A significant association between increased PPQ IC50 and IC90 among Cambodian isolates with DHA-PPQ treatment failure was observed. Nearly all Cambodian and Thai isolates were deemed artemisinin resistant with a > 1 % survival rate for DHA in the ring-stage assay (RSA), though there was no correlation among isolates to indicate cross-resistance between PPQ and artemisinins.
Conclusions: Clinical DHA-PPQ failures appear to be associated with declines in the long-acting partner drug PPQ, though sensitivity appears to remain largely intact for now in western Thailand. Rapid progression of PPQ resistance associated with DHA-PPQ treatment failures in northern Cambodia limits drugs of choice in this region, and urgently requires alternative therapy. The temporary re-introduction of artesunate AS-MQ is the current response to PPQ resistance in this area, due to inverse MQ and PPQ resistance patterns. This will require careful monitoring for re-emergence of MQ resistance, and possible simultaneous resistance to all three drugs (AS, MQ and PPQ).
C1 [Chaorattanakawee, Suwanna; Lon, Chanthap; Jongsakul, Krisada; Sundrakes, Siratchana; Thamnurak, Chatchadaporn; Chattrakarn, Sorayut; Praditpol, Chantida; Buathong, Nillawan; Uthaimongkol, Nichapat; Smith, Philip; Fukuda, Mark M.; Bethell, Delia; Walsh, Douglas S.; Lanteri, Charlotte; Saunders, David] US Army Med Component Armed Forces Res Inst Med S, Bangkok, Thailand.
[Chaorattanakawee, Suwanna] Mahidol Univ, Dept Parasitol & Entomol, Fac Publ Hlth, Bangkok, Thailand.
[Lon, Chanthap; Chann, Soklyda] USAMC AFRIMS, Phnom Penh, Cambodia.
[Gawee, Jariyanart; Sirisopana, Narongrid] Royal Thai Army, Bangkok, Thailand.
[Sok, Somethy; Prom, Satharath] Royal Cambodian Armed Forces, Phnom Penh, Cambodia.
[Kong, Nareth] Natl Ctr Parasitol Entomol & Malaria Control, Phnom Penh, Cambodia.
[Lanteri, Charlotte] Brooke Army Med Ctr, Dept Pathol & Area Lab Serv, Microbiol Sect, San Antonio, TX USA.
RP Lon, C (reprint author), US Army Med Component Armed Forces Res Inst Med S, Bangkok, Thailand.; Lon, C (reprint author), USAMC AFRIMS, Phnom Penh, Cambodia.
EM Chanthapl.ca@afrims.org
FU US Armed Forces Health Surveillance Center
FX Funding for the study was provided by the US Armed Forces Health
Surveillance Center. The funding source did not participate in data
analysis or the final decision to publish the manuscript.
NR 35
TC 0
Z9 0
U1 2
U2 2
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1475-2875
J9 MALARIA J
JI Malar. J.
PD OCT 21
PY 2016
VL 15
AR 519
DI 10.1186/s12936-016-1569-y
PG 12
WC Infectious Diseases; Parasitology; Tropical Medicine
SC Infectious Diseases; Parasitology; Tropical Medicine
GA DZ5DC
UT WOS:000385881200005
PM 27769299
ER
PT J
AU Serak, SV
Hrozhyk, U
Hwang, J
Tabiryan, NV
Steeves, D
Kimball, BR
AF Serak, Svetlana V.
Hrozhyk, Uladzimir
Hwang, Jeoungyeon
Tabiryan, Nelson V.
Steeves, Diane
Kimball, Brian R.
TI High contrast switching of transmission due to electrohydrodynamic
effect in stacked thin systems of liquid crystals
SO APPLIED OPTICS
LA English
DT Article
ID DYNAMIC SCATTERING; ELECTRIC-FIELD; INSTABILITY; BEHAVIOR; DRIVEN
AB We study the opportunity of using electrohydrodynamic instabilities in a nematic liquid crystal mixture with negative dielectric anisotropy for controlling laser beams. Switching between naturally transparent and diffuse light scattering states is achieved by application of low frequency, low amplitude voltages. The specifics of diffuse light scattering state depending on the orientation and thickness of the liquid crystal layer are revealed. The switching occurs on a milliseconds time scale. Combination of thin, flexible liquid crystal cells allows polarization independent, high contrast, fast switching in a broad band of visible wavelengths. (C) 2016 Optical Society of America
C1 [Serak, Svetlana V.; Hrozhyk, Uladzimir; Hwang, Jeoungyeon; Tabiryan, Nelson V.] Beam Engn Adv Measurements Co, 1300 Lee Rd, Orlando, FL 32810 USA.
[Steeves, Diane; Kimball, Brian R.] US Army Natick Soldier Res, Ctr Dev & Engn, 10 Major Greene Ave, Natick, MA 01760 USA.
RP Tabiryan, NV (reprint author), Beam Engn Adv Measurements Co, 1300 Lee Rd, Orlando, FL 32810 USA.
EM nelson@beamco.com
FU U.S. Army Natick Soldier Research, Development and Engineering Center
FX U.S. Army Natick Soldier Research, Development and Engineering Center.
NR 24
TC 1
Z9 1
U1 3
U2 3
PU OPTICAL SOC AMER
PI WASHINGTON
PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA
SN 1559-128X
EI 2155-3165
J9 APPL OPTICS
JI Appl. Optics
PD OCT 20
PY 2016
VL 55
IS 30
BP 8506
EP 8512
DI 10.1364/AO.55.008506
PG 7
WC Optics
SC Optics
GA DZ3BA
UT WOS:000385717100017
PM 27828129
ER
PT J
AU Carrillo, RE
Ramirez, AB
Arce, GR
Barner, KE
Sadler, BM
AF Carrillo, Rafael E.
Ramirez, Ana B.
Arce, Gonzalo R.
Barner, Kenneth E.
Sadler, Brian M.
TI Robust compressive sensing of sparse signals: a review
SO EURASIP JOURNAL ON ADVANCES IN SIGNAL PROCESSING
LA English
DT Review
DE Compressed sensing; Sampling methods; Signal reconstruction; Impulsive
noise; Nonlinear estimation
ID ALTERNATING DIRECTION ALGORITHMS; RESTRICTED ISOMETRY PROPERTY;
ORTHOGONAL MATCHING PURSUIT; IMPULSIVE-NOISE; MYRIAD FILTER; REGRESSION
SHRINKAGE; RANDOM PROJECTIONS; ERROR-CORRECTION; RECOVERY; LASSO
AB Compressive sensing generally relies on the a"" (2) norm for data fidelity, whereas in many applications, robust estimators are needed. Among the scenarios in which robust performance is required, applications where the sampling process is performed in the presence of impulsive noise, i.e., measurements are corrupted by outliers, are of particular importance. This article overviews robust nonlinear reconstruction strategies for sparse signals based on replacing the commonly used a"" (2) norm by M-estimators as data fidelity functions. The derived methods outperform existing compressed sensing techniques in impulsive environments, while achieving good performance in light-tailed environments, thus offering a robust framework for CS.
C1 [Carrillo, Rafael E.] Ecole Polytech Fed Lausanne, Signal Proc Lab LTS5, CH-1015 Lausanne, Switzerland.
[Ramirez, Ana B.] Univ Ind Santander, Bucaramanga, Colombia.
[Arce, Gonzalo R.; Barner, Kenneth E.] Univ Delaware, Dept Elect & Comp Engn, Newark, DE 19716 USA.
[Sadler, Brian M.] US Army Res Lab, Adelphi, MD 20783 USA.
RP Carrillo, RE (reprint author), Ecole Polytech Fed Lausanne, Signal Proc Lab LTS5, CH-1015 Lausanne, Switzerland.
EM rafael.carrillo@epfl.ch; anaberam@uis.edu.co; arce@eecis.udel.edu;
barner@eecis.udel.edu; brian.m.sadler6.civ@mail.mil
NR 84
TC 0
Z9 0
U1 9
U2 9
PU SPRINGER INTERNATIONAL PUBLISHING AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
SN 1687-6180
J9 EURASIP J ADV SIG PR
JI EURASIP J. Adv. Signal Process.
PD OCT 19
PY 2016
AR 108
DI 10.1186/s13634-016-0404-5
PG 17
WC Engineering, Electrical & Electronic
SC Engineering
GA EA4VT
UT WOS:000386614400001
ER
PT J
AU Rivera, JC
Wenke, JC
Pugh, MJ
AF Rivera, Jessica C.
Wenke, Joseph C.
Pugh, Mary Jo
TI OPEN FRACTURE CARE DURING WAR Opportunities for Research
SO JBJS REVIEWS
LA English
DT Review
ID OPEN TIBIA FRACTURES; PRESSURE WOUND THERAPY; LOWER-EXTREMITY TRAUMA;
OPERATION ENDURING FREEDOM; VACUUM-ASSISTED CLOSURE; LIMB SALVAGE
PATIENTS; SOFT-TISSUE COVERAGE; COMPARTMENT SYNDROME; IRAQI FREEDOM;
INFECTIOUS COMPLICATIONS
AB Reported infection rates following severe open fractures of the lower extremity sustained in combat have varied widely, from 23% to 85%. The infection rates have been either similar to or higher than those reported in the civilian trauma literature.
Deployed surgeons have increased the frequency of fasciotomy procedures for limbs with or at risk for clinical compartment syndrome. The long-term sequelae of compartment syndrome and fasciotomies are not clearly defined.
The definition of the term late amputation has varied in the literature, and studies have not consistently included information on the causes of the amputations.
Preclinical and clinical translational studies on the reduction of the rates of infection and other limb morbidities are needed to address the acute care of combat extremity wounds.
C1 [Rivera, Jessica C.; Wenke, Joseph C.; Pugh, Mary Jo] US Army Inst Surg Res, JBSA Ft Sam Houston, San Antonio, TX 78234 USA.
[Rivera, Jessica C.] San Antonio Mil Med Ctr, Dept Orthopaed Surg, San Antonio, TX 78219 USA.
[Pugh, Mary Jo] South Texas Vet Healthcare Syst, VERDICT Res Grp, San Antonio, TX USA.
RP Rivera, JC (reprint author), US Army Inst Surg Res, JBSA Ft Sam Houston, San Antonio, TX 78234 USA.; Rivera, JC (reprint author), San Antonio Mil Med Ctr, Dept Orthopaed Surg, San Antonio, TX 78219 USA.
EM Jessica.c.rivera14.mil@mail.mil
NR 80
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U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 2329-9185
J9 JBJS REV
JI JBJS Rev.
PD OCT 18
PY 2016
VL 4
IS 10
AR e4
DI 10.2106/JBJS.RVW.15.00105
PG 8
WC Surgery
SC Surgery
GA EG4SF
UT WOS:000391033300004
ER
PT J
AU Ripoll, DR
Khavrutskii, I
Wallqvist, A
Chaudhury, S
AF Ripoll, Daniel R.
Khavrutskii, Ilja
Wallqvist, Anders
Chaudhury, Sidhartha
TI Modeling the Role of Epitope Arrangement on Antibody Binding
Stoichiometry in Flaviviruses
SO BIOPHYSICAL JOURNAL
LA English
DT Article
ID WEST-NILE-VIRUS; DENGUE VIRUS; MONOCLONAL-ANTIBODY; MEMBRANE-FUSION;
CRYOELECTRON MICROSCOPY; MEDIATED NEUTRALIZATION; LOCALIZED ADSORPTION;
STRUCTURAL INSIGHTS; SURFACE-PROTEINS; HIGHLY POTENT
AB Cryo-electron-microscopy (cryo-EM) structures of flaviviruses reveal significant variation in epitope occupancy across different monoclonal antibodies that have largely been attributed to epitope-level differences in conformation or accessibility that affect antibody binding. The consequences of these variations for macroscopic properties such as antibody binding and neutralization are the results of the law of mass action-a stochastic process of innumerable binding and unbinding events between antibodies and the multiple binding sites on the flavivirus in equilibrium-that cannot be directly imputed from structure alone. We carried out coarse-grained spatial stochastic binding simulations for nine flavivirus antibodies with epitopes defined by cryo-EM or x-ray crystallography to assess the role of epitope spatial arrangement on antibody-binding stoichiometry, occupancy, and neutralization. In our simulations, all epitopes were equally competent for binding, representing the upper limit of binding stoichiometry that results from epitope spatial arrangement alone. Surprisingly, our simulations closely reproduced the relative occupancy and binding stoichiometry observed in cryo-EM, without having to account for differences in epitope accessibility or conformation, suggesting that epitope spatial arrangement alone may be sufficient to explain differences in binding occupancy and stoichiometry between antibodies. Furthermore, we found that there was significant heterogeneity in binding configurations even at saturating antibody concentrations, and that bivalent antibody binding may be more common than previously thought. Finally, we propose a structure-based explanation for the stoichiometric threshold model of neutralization.
C1 [Ripoll, Daniel R.; Khavrutskii, Ilja; Wallqvist, Anders; Chaudhury, Sidhartha] US Army, DoD Biotechnol High Performance Comp Software App, Telemed & Adv Technol Res Ctr, Med Res & Mat Command, Ft Detrick, MD 21702 USA.
RP Chaudhury, S (reprint author), US Army, DoD Biotechnol High Performance Comp Software App, Telemed & Adv Technol Res Ctr, Med Res & Mat Command, Ft Detrick, MD 21702 USA.
EM sidhartha.chaudhury.civ@mail.mil
FU Military Infectious Diseases Research Program of the U.S. Army Medical
Research and Materiel Command; U.S. Department of Defense (DoD)
High-Performance Computing Modernization Program
FX Support for this research was provided by the Military Infectious
Diseases Research Program of the U.S. Army Medical Research and Materiel
Command and the U.S. Department of Defense (DoD) High-Performance
Computing Modernization Program.
NR 64
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U1 5
U2 5
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 0006-3495
EI 1542-0086
J9 BIOPHYS J
JI Biophys. J.
PD OCT 18
PY 2016
VL 111
IS 8
BP 1641
EP 1654
DI 10.1016/j.bpj.2016.09.003
PG 14
WC Biophysics
SC Biophysics
GA EA0YQ
UT WOS:000386315900010
PM 27760352
ER
PT J
AU Chou, J
Parameswaran, L
Kimball, B
Rothschild, M
AF Chou, Jeffrey
Parameswaran, Lalitha
Kimball, Brian
Rothschild, Mordechai
TI Electrically switchable diffractive waveplates with metasurface aligned
liquid crystals
SO OPTICS EXPRESS
LA English
DT Article
ID HIGH-EFFICIENCY; POLARIZATION GRATINGS; WAVELENGTHS; LENSES
AB Diffractive waveplates and equivalent metasurfaces provide a promising path for applications in thin film beam steering, tunable lenses, and polarization filters. However, fixed metasurfaces alone are unable to be tuned electronically. By combining metasurfaces with tunable liquid crystals, we experimentally demonstrate a single layer device capable of electrically switching a diffractive waveplate design at a measured peak diffraction efficiency of 35%, and a minimum switching voltage of 10V. Furthermore, the nano-scale metasurface aligned liquid crystals are largely independent of variations in wavelength and temperature. We also present a computational analysis of the efficiency limits of liquid crystal based diffractive waveplates, and compare this analysis to experimental measurements. (C) 2016 Massachusetts Institute of Technology
C1 [Chou, Jeffrey; Parameswaran, Lalitha; Rothschild, Mordechai] MIT, Lincoln Lab, Lexington, MA 02420 USA.
[Kimball, Brian] US Army Natick Soldier Res, Ctr Dev & Engn, Natick, MA 01760 USA.
RP Chou, J (reprint author), MIT, Lincoln Lab, Lexington, MA 02420 USA.
EM jeff.chou@ll.mit.edu
FU Department of the Army under Air Force [FA8721-05-C-0002,
FA8702-15-D-0001]
FX This material is based upon work supported by the Department of the Army
under Air Force Contract No. FA8721-05-C-0002 and/or FA8702-15-D-0001.
Any opinions, findings, conclusions or recommendations expressed in this
material are those of the author(s) and do not necessarily reflect the
views of the Department of the Army.
NR 19
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U1 18
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PU OPTICAL SOC AMER
PI WASHINGTON
PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA
SN 1094-4087
J9 OPT EXPRESS
JI Opt. Express
PD OCT 17
PY 2016
VL 24
IS 21
BP 24265
EP 24273
DI 10.1364/OE.24.024265
PG 9
WC Optics
SC Optics
GA EC8NR
UT WOS:000388399100058
PM 27828158
ER
PT J
AU Fotiades, N
Devlin, M
Nelson, RO
Kawano, T
Carroll, JJ
AF Fotiades, N.
Devlin, M.
Nelson, R. O.
Kawano, T.
Carroll, J. J.
TI Feeding of Rh and Ag isomers in fast-neutron-induced reactions
SO PHYSICAL REVIEW C
LA English
DT Article
ID NUCLEAR-DATA SHEETS; HAUSER-FESHBACH; CROSS-SECTIONS; ENERGY REGION;
MODEL; FORMULA; DECAY
AB Background: In (n, n') reactions on stable Ir and Au isotopes in the mass A = 190 region, the experimentally established feeding of the isomers relative to the feeding of the corresponding ground states increases with increasing neutron energy, up to the neutron energy where the (n, 2n) reaction channel opens up, and then decreases.
Purpose: In order to check for similar behavior in the mass A = 100 region, the feeding of isomers and ground states in fast-neutron-induced reactions on stable isotopes in this mass region was studied. This is of especial interest for Rh which can be used as a radiochemical detector.
Methods: Excited states were studied using the (n, n'gamma), (n, 2n gamma), and (n, 3n gamma.) reactions on Rh-103 and Ag-109. A germanium detector array for gamma-ray detection and the broad-spectrum pulsed neutron source of the Los Alamos Neutron Science Center'sWeapons Neutron Research facility were used for the measurement. The energy of the incident neutrons was determined using the time-of-flight technique.
Results: Absolute partial gamma-ray cross sections weremeasured for 57 transitions feeding isomers and ground states in Rh-101,Rh-102,Rh-103 and Ag-107,Ag-108,Ag-109. The feeding of the isomers was found to be very similar in the corresponding reaction channels and it is compared to the feeding determined for the ground states.
Conclusions: The opening of reaction channels at higher neutron energies removes angular momentum from the residual nucleus and reduces the population of the higher-spin isomers relative to the feeding of the lower-spin ground states. Similar behavior was observed in the mass A = 190 region in the feeding of higher-spin isomers, but the reverse behavior was observed in Lu-176 with a lower-spin isomer and a higher-spin ground state.
C1 [Fotiades, N.; Devlin, M.; Nelson, R. O.; Kawano, T.] Los Alamos Natl Lab, Los Alamos, NM 87545 USA.
[Carroll, J. J.] US Army, Res Lab, Adelphi, MD 20783 USA.
RP Fotiades, N (reprint author), Los Alamos Natl Lab, Los Alamos, NM 87545 USA.
EM fotia@lanl.gov
RI Devlin, Matthew/B-5089-2013;
OI Devlin, Matthew/0000-0002-6948-2154; Fotiadis,
Nikolaos/0000-0003-1410-3871
FU US Department of Energy (DOE) [DE-AC52-06NA25396]; DOE
[DE-AC52-06NA25396]; US Army Research Laboratory [W911QX09D0016-0003]
FX This work was performed under the auspices of the US Department of
Energy (DOE) under Contract No. DE-AC52-06NA25396. This work has
benefited from use of the LANSCE accelerator facility supported under
DOE Contract No. DE-AC52-06NA25396. The enriched 109Ag target
was provided by Ecopulse, Inc. under US Army Research Laboratory
Contract No. W911QX09D0016-0003.
NR 44
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PU AMER PHYSICAL SOC
PI COLLEGE PK
PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA
SN 2469-9985
EI 2469-9993
J9 PHYS REV C
JI Phys. Rev. C
PD OCT 17
PY 2016
VL 94
IS 4
AR 044608
DI 10.1103/PhysRevC.94.044608
PG 9
WC Physics, Nuclear
SC Physics
GA DZ9CE
UT WOS:000386170000005
ER
PT J
AU Folarin, OA
Ehichioya, D
Schaffner, SF
Winnicki, SM
Wohl, S
Eromon, P
West, KL
Gladden-Young, A
Oyejide, NE
Matranga, CB
Deme, AB
James, A
Tomkins-Tinch, C
Onyewurunwa, K
Ladner, JT
Palacios, G
Nosamiefan, I
Andersen, KG
Omilabu, S
Park, DJ
Yozwiak, NL
Nasidi, A
Garry, RF
Tomori, O
Sabeti, PC
Happi, CT
AF Folarin, Onikepe A.
Ehichioya, Deborah
Schaffner, Stephen F.
Winnicki, Sarah M.
Wohl, Shirlee
Eromon, Philomena
West, Kendra L.
Gladden-Young, Adrianne
Oyejide, Nicholas E.
Matranga, Christian B.
Deme, Awa Bineta
James, Ayorinde
Tomkins-Tinch, Christopher
Onyewurunwa, Kenneth
Ladner, Jason T.
Palacios, Gustavo
Nosamiefan, Iguosadolo
Andersen, Kristian G.
Omilabu, Sunday
Park, Daniel J.
Yozwiak, Nathan L.
Nasidi, Abdusallam
Garry, Robert F.
Tomori, Oyewale
Sabeti, Pardis C.
Happi, Christian T.
TI Ebola Virus Epidemiology and Evolution in Nigeria
SO JOURNAL OF INFECTIOUS DISEASES
LA English
DT Article
DE Ebola; genomic; phylogeny; epidemiology; Nigeria; sequencing; outbreak
ID SIERRA-LEONE; TRANSMISSION; REPLICATION; DYNAMICS; OUTBREAK; LIBERIA;
SAMPLES; GENOME; MAFFT; LASSA
AB Containment limited the 2014 Nigerian Ebola virus (EBOV) disease outbreak to 20 reported cases and 8 fatalities. We present here clinical data and contact information for at least 19 case patients, and full-length EBOV genome sequences for 12 of the 20. The detailed contact data permits nearly complete reconstruction of the transmission tree for the outbreak. The EBOV genomic data are consistent with that tree. It confirms that there was a single source for the Nigerian infections, shows that the Nigerian EBOV lineage nests within a lineage previously seen in Liberia but is genetically distinct from it, and supports the conclusion that transmission from Nigeria to elsewhere did not occur.
C1 [Folarin, Onikepe A.; Ehichioya, Deborah; Eromon, Philomena; Oyejide, Nicholas E.; Onyewurunwa, Kenneth; Tomori, Oyewale; Happi, Christian T.] Redeemers Univ, Dept Biol Sci, Ede, Osun State, Nigeria.
[Folarin, Onikepe A.; Ehichioya, Deborah; Eromon, Philomena; Onyewurunwa, Kenneth; Park, Daniel J.; Yozwiak, Nathan L.; Garry, Robert F.; Sabeti, Pardis C.; Happi, Christian T.] Redeemers Univ, African Ctr Excellence Genom Infect Dis, Ede, Osun State, Nigeria.
[James, Ayorinde] Univ Lagos, Coll Med, Dept Biochem, Lagos, Nigeria.
[Omilabu, Sunday] Univ Lagos, Coll Med, Dept Med Microbiol & Parasitol, Lagos, Nigeria.
[Tomori, Oyewale] Nigerian Acad Sci, Lagos, Nigeria.
[Nasidi, Abdusallam] Nigeria Ctr Dis Control, Abuja, Nigeria.
[Schaffner, Stephen F.; Winnicki, Sarah M.; Wohl, Shirlee; West, Kendra L.; Gladden-Young, Adrianne; Matranga, Christian B.; Tomkins-Tinch, Christopher; Nosamiefan, Iguosadolo; Park, Daniel J.; Yozwiak, Nathan L.; Sabeti, Pardis C.] Broad Inst Harvard & MIT, Cambridge, MA 02142 USA.
[Schaffner, Stephen F.; Winnicki, Sarah M.; Wohl, Shirlee; Yozwiak, Nathan L.; Sabeti, Pardis C.] Harvard Univ, Dept Organism & Evolutionary Biol, FAS Ctr Syst Biol, Cambridge, MA 02138 USA.
[Sabeti, Pardis C.] Howard Hughes Med Inst, Chevy Chase, MD USA.
[Ladner, Jason T.; Palacios, Gustavo] US Army Med Res Inst Infect Dis, Ctr Genome Sci, Frederick, MA USA.
[Andersen, Kristian G.] Scripps Res Inst, Scripps Translat Sci Inst, La Jolla, CA 92037 USA.
[Garry, Robert F.] Tulane Univ, Dept Microbiol & Immunol, New Orleans, LA 70118 USA.
[Deme, Awa Bineta] Univ Cheikh Anta Diop Dakar, Dept Parasitol & Mycol, Dakar, Senegal.
RP Schaffner, SF (reprint author), Broad Inst Harvard & MIT, Cambridge, MA 02142 USA.; Happi, CT (reprint author), Redeemers Univ, Ede, Osun State, Nigeria.
EM sfs@broadinstitute.org; happic@run.edu.ng
RI Schaffner, Stephen/D-1189-2011
FU Illumina Corporation; United States Agency for International Development
[OAA-G-15-00001]; National Institutes of Health (NIH) [5U01HG007480-03];
World Bank [ACE 019]; Bill and Melinda Gates Foundation [OPP1123407];
Howard Hughes Medical Institute; National Institute of Allergy and
Infectious Diseases, NIH, Department of Health and Human Services
[U19AI110818]
FX This work was supported by grants from Illumina Corporation and the
United States Agency for International Development (grant
OAA-G-15-00001), the National Institutes of Health (NIH) (grant
5U01HG007480-03), the World Bank (ACE 019), the Bill and Melinda Gates
Foundation (grant OPP1123407), and the Howard Hughes Medical Institute
(to P. C. S.). Sequencing and analysis work at the Broad Institute was
supported by federal funds from the National Institute of Allergy and
Infectious Diseases, NIH, Department of Health and Human Services (under
grant U19AI110818).
NR 24
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U1 4
U2 4
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0022-1899
EI 1537-6613
J9 J INFECT DIS
JI J. Infect. Dis.
PD OCT 15
PY 2016
VL 214
SU 3
BP S102
EP S109
DI 10.1093/infdis/jiw190
PG 8
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA DZ8VA
UT WOS:000386148800002
PM 27377746
ER
PT J
AU Kortepeter, MG
Kwon, EH
Hewlett, AL
Smith, PW
Cieslak, TJ
AF Kortepeter, Mark G.
Kwon, Elena H.
Hewlett, Angela L.
Smith, Philip W.
Cieslak, Theodore J.
TI Containment Care Units for Managing Patients With Highly Hazardous
Infectious Diseases: A Concept Whose Time Has Come
SO JOURNAL OF INFECTIOUS DISEASES
LA English
DT Article
DE containment care; Ebola; Marburg; Lassa; viral hemorrhagic fever;
biocontainment patient care unit; hazardous; infectious disease;
isolation; quarantine
ID SERIOUS COMMUNICABLE DISEASES; EBOLA HEMORRHAGIC-FEVER;
NONHUMAN-PRIMATES; VIRUS; TRANSMISSION; OUTBREAK; PIGS
AB The concept of containment care for patients with highly hazardous infectious diseases originated in conjunction with the development of sophisticated biosafety level 4 laboratories at the US Army Medical Research Institute of Infectious Diseases in the late 1960s. Over time, the original containment facility served as a model for the development of other facilities in the United States at government and academic centers. The Ebola outbreak of 2014-2015 brought the issue of containment care into the mainstream and led to the development of such capabilities at strategic points around the country. We describe the original concepts behind development of such facilities, how the concept and acceptance has evolved over time, and how the guidelines for managing patients infected with viral hemorrhagic fevers have evolved as new information has been learned about protecting medical care providers from highly hazardous infectious pathogens.
C1 [Kortepeter, Mark G.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
[Kwon, Elena H.] US Army Med Res Inst Infect Dis, Ft Detrick, MD USA.
[Hewlett, Angela L.] Univ Nebraska Med Ctr, Div Infect Dis, Omaha, NE USA.
[Smith, Philip W.; Cieslak, Theodore J.] Univ Nebraska Med Ctr, Coll Publ Hlth, Omaha, NE USA.
[Hewlett, Angela L.; Smith, Philip W.; Cieslak, Theodore J.] Univ Nebraska Med Ctr, Nebraska Biocontainment Unit, Omaha, NE USA.
RP Kortepeter, MG (reprint author), 1114 Churchview Pl, Potomac, MD 20854 USA.
EM mark.kortepeter@gmail.com
NR 34
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PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0022-1899
EI 1537-6613
J9 J INFECT DIS
JI J. Infect. Dis.
PD OCT 15
PY 2016
VL 214
SU 3
BP S137
EP S141
DI 10.1093/infdis/jiw292
PG 5
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA DZ8VA
UT WOS:000386148800005
PM 27651413
ER
PT J
AU Phan, JC
Pettitt, J
George, JS
Fakoli, LS
Taweh, FM
Bateman, SL
Bennett, RS
Norris, SL
Spinnler, DA
Pimentel, G
Sahr, PK
Bolay, FK
Schoepp, RJ
AF Phan, Jill C.
Pettitt, James
George, Josiah S.
Fakoli, Lawrence S., III
Taweh, Fahn M.
Bateman, Stacey L.
Bennett, Richard S.
Norris, Sarah L.
Spinnler, David A.
Pimentel, Guillermo
Sahr, Phillip K.
Bolay, Fatorma K.
Schoepp, Randal J.
TI Lateral Flow Immunoassays for Ebola Virus Disease Detection in Liberia
SO JOURNAL OF INFECTIOUS DISEASES
LA English
DT Article
DE Ebola; EBOV; Ebola virus disease; EVD; diagnostics; lateral flow;
immunoassay; LFI; antibodies; Liberia; West Africa
ID HEMORRHAGIC-FEVER; OUTBREAK
AB Background. Lateral flow immunoassays (LFIs) are point-of-care diagnostic assays that are designed for single use outside a formal laboratory, with in-home pregnancy tests the best-known example of these tests. Although the LFI has some limitations over more-complex immunoassay procedures, such as reduced sensitivity and the potential for false-positive results when using complex sample matrices, the assay has the benefits of a rapid time to result and ease of use. These benefits make it an attractive option for obtaining rapid results in an austere environment. In an outbreak of any magnitude, a field-based rapid diagnostic assay would allow proper patient transport and for safe burials to be conducted without the delay caused by transport of samples between remote villages and testing facilities. Use of such point-of-care instruments in the ongoing Ebola virus disease (EVD) outbreak in West Africa would have distinct advantages in control and prevention of local outbreaks, but proper understanding of the technology and interpretation of results are important.
Methods.aEuro integral In this study, a LFI, originally developed by the Naval Medical Research Center for Ebola virus environmental testing, was evaluated for its ability to detect the virus in clinical samples in Liberia. Clinical blood and plasma samples and post mortem oral swabs submitted to the Liberian Institute for Biomedical Research, the National Public Health Reference Laboratory for EVD testing, were tested and compared to results of real-time reverse transcription-polymerase chain reaction (rRT-PCR), using assays targeting Ebola virus glycoprotein and nucleoprotein.
Results.aEuro integral The LFI findings correlated well with those of the real-time RT-PCR assays used as benchmarks.
Conclusions.aEuro integral Rapid antigen-detection tests such as LFIs are attractive alternatives to traditional immunoassays but have reduced sensitivity and specificity, resulting in increases in false-positive and false-negative results. An understanding of the strengths, weaknesses, and limitations of a particular assay lets the diagnostician choose the correct situation to use the correct assay and properly interpret the results.
C1 [Phan, Jill C.; Spinnler, David A.; Pimentel, Guillermo] Naval Med Res Ctr, Biol Def Res Directorate, Ft Detrick, MD USA.
[Pettitt, James; Bennett, Richard S.] NIH, Integrated Res Facil, Ft Detrick, MD USA.
[Bateman, Stacey L.; Norris, Sarah L.; Schoepp, Randal J.] US Army Med Res Inst Infect Dis, 1425 Porter St, Ft Detrick, MD 21702 USA.
[George, Josiah S.; Fakoli, Lawrence S., III; Taweh, Fahn M.; Sahr, Phillip K.; Bolay, Fatorma K.] Liberian Inst Biomed Res, Charlesville, Liberia.
RP Schoepp, RJ (reprint author), US Army Med Res Inst Infect Dis, 1425 Porter St, Ft Detrick, MD 21702 USA.
EM randal.j.schoepp.civ@mail.mil
FU Department of Defense Medical Countermeasure Systems-Critical Reagents
Program; Defense Threat Reduction Agency-Cooperative Biological
Engagement Program; Division of Global Emerging Infections Surveillance
and Response System (GEIS) Operations at the Armed Forces Health
Surveillance Center; Liberian Ministry of Health and Social Welfare;
National Institute of Allergy and Infectious Diseases Integrated
Research Facility; Battelle Memorial Institute
FX This work was supported by the Department of Defense Medical
Countermeasure Systems-Critical Reagents Program (to J. C. P., D. A. S.,
G. P., and R. J. S.), the Defense Threat Reduction Agency-Cooperative
Biological Engagement Program (to J. C. P., S. L. B., S. L. N., D. A.
S., G. P., and R. J. S.), the Division of Global Emerging Infections
Surveillance and Response System (GEIS) Operations at the Armed Forces
Health Surveillance Center (to R. J. S.), the Liberian Ministry of
Health and Social Welfare (to J. S. G., L. S. F., F. M. T., P. K. S.,
and F. K. B.), the National Institute of Allergy and Infectious Diseases
Integrated Research Facility, and Battelle Memorial Institute (to J. P.
and R. S. B.).
NR 15
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U1 3
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PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0022-1899
EI 1537-6613
J9 J INFECT DIS
JI J. Infect. Dis.
PD OCT 15
PY 2016
VL 214
SU 3
BP S222
EP S228
DI 10.1093/infdis/jiw251
PG 7
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA DZ8VA
UT WOS:000386148800017
PM 27443616
ER
PT J
AU Kilianski, A
Nuzzo, JB
Modjarrad, K
AF Kilianski, Andy
Nuzzo, Jennifer B.
Modjarrad, Kayvon
TI Comment on "Gain-of-Function Research and the Relevance to Clinical
Practice" Reply
SO JOURNAL OF INFECTIOUS DISEASES
LA English
DT Letter
C1 [Kilianski, Andy] Edgewood Chem Biol Ctr, BioDef Branch, Biosci Div, Aberdeen Proving Ground, MD 21010 USA.
[Nuzzo, Jennifer B.] Univ Pittsburgh Med Ctr, Ctr Hlth Secur, Baltimore, MD USA.
[Modjarrad, Kayvon] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA.
RP Kilianski, A (reprint author), Edgewood Chem Biol Ctr, BioDef Branch, Biosci Div, Aberdeen Proving Ground, MD 21010 USA.
EM akilians@gmu.edu
NR 5
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U1 0
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PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0022-1899
EI 1537-6613
J9 J INFECT DIS
JI J. Infect. Dis.
PD OCT 15
PY 2016
VL 214
IS 8
BP 1285
EP U170
DI 10.1093/infdis/jiw349
PG 3
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA DZ8UL
UT WOS:000386147200028
PM 27503366
ER
PT J
AU Lieberman, HR
Farina, EK
Caldwell, J
Williams, KW
Thompson, LA
Niro, PJ
Grohmann, KA
McClung, JP
AF Lieberman, Harris R.
Farina, Emily K.
Caldwell, John
Williams, Kelly W.
Thompson, Lauren A.
Niro, Philip J.
Grohmann, Kyle A.
McClung, James P.
TI Cognitive function, stress hormones, heart rate and nutritional status
during simulated captivity in military survival training
SO PHYSIOLOGY & BEHAVIOR
LA English
DT Article
DE SERE school; Mood; Psychomotor vigilance (PVT); N-back task; Fatigue
ID PSYCHOLOGICAL STRESS; SALIVARY CORTISOL; SUSTAINED OPERATIONS;
TRANSFERRIN RECEPTOR; SLEEP-DEPRIVATION; PHYSICAL-ACTIVITY;
BODY-COMPOSITION; ADRENAL-FUNCTION; DECISION-MAKING; NEUROPEPTIDE-Y
AB Stress influences numerous psychological and physiological processes, and its effects have practical implications in a variety of professions and real-world activities. However, few studies have concurrently assessed multiple behavioral, hormonal, nutritional and heart-rate responses of humans to acute, severe stress. This investigation simultaneously assessed cognitive, affective, hormonal, and heart -rate responses induced by an intensely stressful real-world-environment designed to simulate wartime captivity. Sixty males were evaluated during and immediately following participation in U.S. Army Survival, Evasion, Resistance, and Escape (SERE) school, three weeks of intense but standardized training for Soldiers at risk of capture. Simulated captivity and intense mock interrogations degraded grammatical reasoning (p < 0.005), sustained-attention (p < 0.001), working memory (p <0.05) and all aspects of mood assessed by the Profile of Mood States (POMS) questionnaire: Tension/Anxiety, Depression/Dejection, Anger/Hostility, Vigor/Activity, Fatigue/Inertia; Confusion/Bewilderment, and Total Mood Disturbance (p < 0.001) It also elevated heart rate (p < 0.001); increased serum and salivary cortisol and dehydroepiandrosterone-sulfate (DHEA-s) (p < 0.01); elevated serum epinephrine, norepinephrine, and soluble transferrin receptors (sTfR) (p < 0.01); increased salivary neuropeptide-Y (NPY) (p < 0.001); and decreased serum prolactin and serum and salivary testosterone (p < 0.001). Partial recovery was observed immediately after training, but stress -induced changes, particularly in body weight and several of the biomarkers, persisted. This study demonstrates that when individuals were exposed to realistic and controlled simulated captivity, cognition, mood, stress hormones, nutritional status and heart rate are simultaneously altered, and each of these subsequently recovers at different rates. Published by Elsevier Inc.
C1 [Lieberman, Harris R.; Farina, Emily K.; Caldwell, John; Williams, Kelly W.; Thompson, Lauren A.; Niro, Philip J.; McClung, James P.] US Army Res Inst Environm Med, Mil Nutr Div, Gen Greene Ave,Bldg 42, Natick, MA 01760 USA.
[Farina, Emily K.; Caldwell, John; Williams, Kelly W.; Thompson, Lauren A.] Oak Ridge Inst Sci & Educ, Bekamp, MD 21017 USA.
[Grohmann, Kyle A.] USASOC, John F Kennedy Special Warfare Ctr & Sch, Ft Bragg, NC 28310 USA.
RP Lieberman, HR (reprint author), US Army Res Inst Environm Med, Mil Nutr Div, Gen Greene Ave,Bldg 42, Natick, MA 01760 USA.
EM harris.r.lieberman.civ@mail.mil
FU U.S. Army Medical Research and Materiel Command (USAMRMC)
FX This work was supported by core funding from the U.S. Army Medical
Research and Materiel Command (USAMRMC). The views, opinions, and
findings in this report are those of the authors and should not be
construed as an official Department of Defense or Army position, policy,
or decision, unless so designated by other official documentation.
Citations of commercial organizations and trade names in this report do
not constitute an official Department of the Army endorsement or
approval of the products or services of these organizations. The
investigators have adhered to the policies for protection of human
subjects as prescribed in DOD Instruction 3216.02 and the research was
conducted in adherence with the provisions of 32 CFR Part 219.
NR 89
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U2 22
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0031-9384
J9 PHYSIOL BEHAV
JI Physiol. Behav.
PD OCT 15
PY 2016
VL 165
BP 86
EP 97
DI 10.1016/j.physbeh.2016.06.037
PG 12
WC Psychology, Biological; Behavioral Sciences
SC Psychology; Behavioral Sciences
GA DY0LS
UT WOS:000384788900011
PM 27374427
ER
PT J
AU Guziewski, M
Coleman, SP
Weinberger, CR
AF Guziewski, Matthew
Coleman, Shawn P.
Weinberger, Christopher R.
TI Atomistic investigation into the atomic structure and energetics of the
ferrite-cementite interface: The Bagaryatskii orientation
SO ACTA MATERIALIA
LA English
DT Article
DE Dislocations; Nanostructure; Plastic deformation; Fe-C alloys; Atomistic
simulations
ID GRAIN-BOUNDARY STRUCTURE; MOLECULAR-DYNAMICS SIMULATIONS; SEVERE
PLASTIC-DEFORMATION; CENTERED-CUBIC METALS; PROPERTY RELATIONSHIPS;
MECHANICAL-PROPERTIES; HYPOEUTECTOID STEEL; CRYSTAL-STRUCTURE; PEARLITIC
STEELS; BCC METALS
AB Atomistic modeling was used to investigate the energetics and structure of the Bagaryatskii orientation relationship between ferrite and cementite within pearlite. The atomic level results show that the interface structure consists of a rectangular array of dislocations that lie along the high symmetry directions of the interface. The interface can be constructed using three different atomic terminating planes in the cementite structure, which dictates the chemistry and registry of the interface and controls the interfacial energy. The FeC-Fe terminating plane is always the lowest energy because the interfacial dislocations are most easily able to spread on these planes, thus reducing the interfacial energy. These atomistic results compare favorably with results from a continuum model based on O-lattice theory and anisotropic continuum theory. The dislocation spacing and interfacial energies predicted from the continuum level agree well with the atomistic simulation results. (C) 2016 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
C1 [Guziewski, Matthew; Weinberger, Christopher R.] Drexel Univ, Dept Mech Engn & Mech, Philadelphia, PA 19104 USA.
[Coleman, Shawn P.] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RP Guziewski, M (reprint author), Drexel Univ, Dept Mech Engn & Mech, Philadelphia, PA 19104 USA.
EM guziewsk@rams.colostate.edu
FU Petroleum Research Fund, PRF [54697-DNI10]
FX This research was supported though a grant from the Petroleum Research
Fund, PRF # 54697-DNI10. Many of the simulations were run using Drexel
University's PROTEUS computing cluster, part of the University Computing
Facility.
NR 64
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U1 6
U2 6
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 1359-6454
EI 1873-2453
J9 ACTA MATER
JI Acta Mater.
PD OCT 15
PY 2016
VL 119
BP 184
EP 192
DI 10.1016/j.actamat.2016.08.017
PG 9
WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical
Engineering
SC Materials Science; Metallurgy & Metallurgical Engineering
GA DY0HQ
UT WOS:000384778300018
ER
PT J
AU Allison, SO
Eggleston-Ahearn, AM
Courtney, CJ
Hardy, CD
Malbrue, RA
Quammen, JK
Sander, WE
Swartz, AA
Wexler, SR
Zedek, AS
AF Allison, Sarah O.
Eggleston-Ahearn, Aimee M.
Courtney, Cynthia J.
Hardy, Corinn D.
Malbrue, Raphael A.
Quammen, Jennifer K.
Sander, William E.
Swartz, Aleisha A.
Wexler, Seth R.
Zedek, Andrea S.
TI Implementing wellness in the veterinary workplace
SO JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION
LA English
DT Editorial Material
ID WORKSITE-HEALTH-PROMOTION; MENTAL-HEALTH; PROGRAM; EXPERIENCE; SUICIDE;
JOHNSON; RISK; LIFE; UK
C1 [Allison, Sarah O.] Univ Illinois, Dept Vet Clin Med, Coll Vet Med, Urbana, IL 61801 USA.
[Allison, Sarah O.] Univ Illinois, Div Anim Resources, Urbana, IL 61801 USA.
[Eggleston-Ahearn, Aimee M.] Eggleston Equine LLC, 483 Ctr Rd, Woodstock, CT 06281 USA.
[Courtney, Cynthia J.] Grandview Anim Hosp, 1006 Main St, Grandview, MO 64030 USA.
[Hardy, Corinn D.] VA Cent Iowa Hlth Care Syst, 3600 30th St, Des Moines, IA 50310 USA.
[Hardy, Corinn D.] US Army Reserve, Army Publ Hlth Ctr, 5158 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA.
[Malbrue, Raphael A.] Louisiana State Univ, Div Lab Anim Med, Baton Rouge, LA 70803 USA.
[Malbrue, Raphael A.] Louisiana State Univ, Sch Vet Med, Baton Rouge, LA 70803 USA.
[Quammen, Jennifer K.] High Performance Living LLC, 809 Foinavon Lane, Walton, KY 41094 USA.
[Sander, William E.] Booz Allen Hamilton, 8209 Terminal Rd, Lorton, VA 22079 USA.
[Swartz, Aleisha A.] Hawaiian Humane Soc, 2700 Waialae Ave, Honolulu, HI 96826 USA.
[Wexler, Seth R.] Banfield Pet Hosp, 18101 SE 6th Way, Vancouver, WA 98683 USA.
[Zedek, Andrea S.] Zedek Poultry Consulting LLC, 9 Trowbridge Ct, Simpsonville, SC 29681 USA.
RP Allison, SO (reprint author), Univ Illinois, Dept Vet Clin Med, Coll Vet Med, Urbana, IL 61801 USA.; Allison, SO (reprint author), Univ Illinois, Div Anim Resources, Urbana, IL 61801 USA.
EM allison3@illinois.edu
NR 28
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U1 4
U2 4
PU AMER VETERINARY MEDICAL ASSOC
PI SCHAUMBURG
PA 1931 N MEACHAM RD SUITE 100, SCHAUMBURG, IL 60173-4360 USA
SN 0003-1488
EI 1943-569X
J9 JAVMA-J AM VET MED A
JI JAVMA-J. Am. Vet. Med. Assoc.
PD OCT 15
PY 2016
VL 249
IS 8
BP 879
EP 881
PG 3
WC Veterinary Sciences
SC Veterinary Sciences
GA DX9MU
UT WOS:000384720300026
PM 27700276
ER
PT J
AU Danielson, KT
Adley, MD
Williams, TN
AF Danielson, Kent T.
Adley, Mark D.
Williams, T. Neil
TI Second-order finite elements for Hex-Dominant explicit methods in
nonlinear solid dynamics
SO FINITE ELEMENTS IN ANALYSIS AND DESIGN
LA English
DT Article
DE Hex-Dominant meshing; Finite element; Wedge; Higher order; Explicit time
integration
ID ASSUMED STRAIN STABILIZATION; TETRAHEDRAL ELEMENTS; HOURGLASS CONTROL;
CONCRETE; MESH
AB Hexahedral-dominant modeling approaches strike a balance of meshing ease and accuracy/efficiency by exploiting wedge (and/or pyramid) elements to transition from hexahedral elements to volumes filled by other types. Unfortunately, first-order wedges are frequently very poor performers and are the only ones typically contained in explicit solid dynamic programs. The historic preference of first-order elements with explicit methods has frequently been for simplicity and cost, but has also been from the lack of both a satisfactory consistent nodal loading distribution and an acceptable mass lumping technique for serendipity elements. Row summation lumping, for example, produces negative and zero vertex node masses for the popular fifteen and eighteen node wedges, respectively, and zero vertex nodal loads from a uniform traction on the triangular faces. The paper first presents twenty-one node wedge element formulations that produce all positive nodal loads from uniform tractions and row summation mass lumping for this element is shown to produce all positive nodal masses. In addition, they are compatible with other second-order elements applicable to lumped mass explicit methods. Performance is assessed in standard benchmark problems and practical applications using various elastic and elastic-plastic material models and involving very large strains/deformations, severe distortions, and contact-impact. These wedge elements are evaluated on their own as well as part of hexahedral-dominant meshes that use wedges for fill regions and transition from hexahedral to tetrahedral elements. In all cases, these elements performed satisfactorily and thus demonstrate their viability and benefits for practical applications, especially for fill and transition regions of low interest. (C) 2016 Published by Elsevier B.V.
C1 [Danielson, Kent T.] US Army Engineer Res & Dev Ctr, Geotech & Struct Lab, CEERD GMR, Res Grp,Engn Syst & Mat Div, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
[Adley, Mark D.; Williams, T. Neil] US Army Engineer Res & Dev Ctr, Geotech & Struct Lab, CEERD GMR, Impact & Explos Effects Branch, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
RP Danielson, KT (reprint author), US Army Engineer Res & Dev Ctr, Geotech & Struct Lab, CEERD GMR, Res Grp,Engn Syst & Mat Div, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
EM Kent.T.Danielson@usace.army.mil; Mark.D.Adley@usace.army.mil;
Neil.T.Williams@usace.army.mil
FU DOD High Performance Computing Modernization Program at the ERDC DOD
Supercomputing Resource Center (DSRC)
FX Permission to publish was granted by Director, Geotechnical and
Structures Laboratory. The work was supported in part by grants of
computer time from the DOD High Performance Computing Modernization
Program at the ERDC DOD Supercomputing Resource Center (DSRC).
NR 41
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U1 5
U2 5
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0168-874X
EI 1872-6925
J9 FINITE ELEM ANAL DES
JI Finite Elem. Anal. Des.
PD OCT 15
PY 2016
VL 119
BP 63
EP 77
DI 10.1016/j.finel.2016.02.008
PG 15
WC Mathematics, Applied; Mechanics
SC Mathematics; Mechanics
GA DS5TB
UT WOS:000380844100005
ER
PT J
AU Dowd, KA
Ko, SY
Morabito, KM
Yang, ES
Pelc, RS
DeMaso, CR
Castilho, LR
Abbink, P
Boyd, M
Nityanandam, R
Gordon, DN
Gallagher, JR
Chen, XJ
Todd, JP
Tsybovsky, Y
Harris, A
Huang, YJS
Higgs, S
Vanlandingham, DL
Andersen, H
Lewis, MG
De La Barrera, R
Eckels, KH
Jarman, RG
Nason, MC
Barouch, DH
Roederer, M
Kong, WP
Mascola, JR
Pierson, TC
Graham, BS
AF Dowd, Kimberly A.
Ko, Sung-Youl
Morabito, Kaitlyn M.
Yang, Eun Sung
Pelc, Rebecca S.
DeMaso, Christina R.
Castilho, Leda R.
Abbink, Peter
Boyd, Michael
Nityanandam, Ramya
Gordon, David N.
Gallagher, John Robert
Chen, Xuejun
Todd, John-Paul
Tsybovsky, Yaroslav
Harris, Audray
Huang, Yan-Jang S.
Higgs, Stephen
Vanlandingham, Dana L.
Andersen, Hanne
Lewis, Mark G.
De La Barrera, Rafael
Eckels, Kenneth H.
Jarman, Richard G.
Nason, Martha C.
Barouch, Dan H.
Roederer, Mario
Kong, Wing-Pui
Mascola, John R.
Pierson, Theodore C.
Graham, Barney S.
TI Rapid development of a DNA vaccine for Zika virus
SO SCIENCE
LA English
DT Article
ID JAPANESE ENCEPHALITIS-VIRUS; TICK-BORNE ENCEPHALITIS; DENGUE VIRUS;
CANDIDATE VACCINE; HEALTHY-ADULTS; ANTIBODY; NEUTRALIZATION;
PREMEMBRANE; PROTECTION; CHALLENGE
AB Zika virus (ZIKV) was identified as a cause of congenital disease during the explosive outbreak in the Americas and Caribbean that began in 2015. Because of the ongoing fetal risk from endemic disease and travel-related exposures, a vaccine to prevent viremia in women of childbearing age and their partners is imperative. We found that vaccination with DNA expressing the premembrane and envelope proteins of ZIKV was immunogenic in mice and nonhuman primates, and protection against viremia after ZIKV challenge correlated with serum neutralizing activity. These data not only indicate that DNA vaccination could be a successful approach to protect against ZIKV infection, but also suggest a protective threshold of vaccine induced neutralizing activity that prevents viremia after acute infection.
C1 [Dowd, Kimberly A.; Pelc, Rebecca S.; DeMaso, Christina R.; Gordon, David N.; Pierson, Theodore C.] NIAID, Viral Pathogenesis Sect, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA.
[Ko, Sung-Youl; Morabito, Kaitlyn M.; Yang, Eun Sung; Castilho, Leda R.; Chen, Xuejun; Todd, John-Paul; Roederer, Mario; Kong, Wing-Pui; Mascola, John R.; Graham, Barney S.] NIAID, Vaccine Res Ctr, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA.
[Castilho, Leda R.] Univ Fed Rio de Janeiro, COPPE, Chem Engn Program, Inst Alberto Luiz Coimbra Posgrad & Pesquisa Engn, Rio De Janeiro, Brazil.
[Abbink, Peter; Boyd, Michael; Nityanandam, Ramya; Barouch, Dan H.] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Ctr Virol & Vaccine Res, Boston, MA 02215 USA.
[Gallagher, John Robert; Harris, Audray] NIAID, Struct Informat Unit, Infect Dis Lab, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA.
[Tsybovsky, Yaroslav] Frederick Natl Lab Canc Res, Electron Microscopy Lab, Canc Res Technol Program, Frederick, MD 21702 USA.
[Huang, Yan-Jang S.; Higgs, Stephen; Vanlandingham, Dana L.] Kansas State Univ, Coll Vet Med, Dept Diagnost Med Pathobiol, Manhattan, KS 66506 USA.
[Andersen, Hanne; Lewis, Mark G.] Bioqual, Rockville, MD 20852 USA.
[De La Barrera, Rafael; Eckels, Kenneth H.] Walter Reed Army Inst Res, Translat Med Branch, Silver Spring, MD 20910 USA.
[Jarman, Richard G.] Walter Reed Army Inst Res, Viral Dis Branch, Silver Spring, MD 20910 USA.
[Nason, Martha C.] NIAID, Biostat Res Branch, Div Clin Res, NIH, Bethesda, MD 20852 USA.
RP Pierson, TC (reprint author), NIAID, Viral Pathogenesis Sect, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA.; Graham, BS (reprint author), NIAID, Vaccine Res Ctr, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA.
EM piersontc@niaid.nih.gov; bgraham@mail.nih.gov
FU NIH [VRC5283, VRC5288, VRC8400, VRC8111, VRC4974]; National Institute of
Allergy and Infectious Diseases; Department of Diagnostic Medicine and
Pathobiology, College of Veterinary Medicine, Kansas State University;
Frederick National Laboratory for Cancer Research, NIH
[HHSN261200800001E]; Leidos Biomedical Research
FX We thank A. Fauci, H. Marston, J. Ledgerwood, S. Whitehead, N. Michael,
and M. Crank for scientific advice and comments; J. Stein and M. Young
for coordinating collaborations; A. Cook and A. Dodson for the macaque
work; K. Leung, L. Wang, W. Shi, K. Foulds, M. Donaldson, B. Fisher, A.
Creanga, D. Scorpio, and B. Dekosky for laboratory and animal study
support; M. Diamond for ZIKV-specific antibodies provided before
publication; N. Bourne and A. Barrett for scientific advice and murine
experiments; E. Moseley for serological assays; T. Pato for scientific
discussion on the purification of SVPs; B. Hartman for help with figure
optimization; R. Larocca and A. Badamchi-Zadeh for murine experiments;
and N. Mercado for shipping and coordination. The data are tabulated in
the main paper and in the supplementary materials. The opinions or
assertions contained herein are the private views of the authors and are
not to be construed as reflecting the official views of the U.S. Army or
Department of Defense. VRC5283, VRC5288, VRC8400, VRC8111, and VRC4974
are available from NIH under a material transfer agreement. ZIKV strain
PRVABC59 challenge stock is available from Kansas State University under
a material transfer agreement. A patent application describing candidate
ZIKV vaccines has been filed with the following authors listed as
inventors: B.S.G., T.C.P., W.-P. K., S.-Y.K., K. A. D., E.S.Y., R.S.P.,
C.R.D., L.R.C., and J. R. M. This work was supported by intramural
funding from the National Institute of Allergy and Infectious Diseases;
startup funding from the Department of Diagnostic Medicine and
Pathobiology, College of Veterinary Medicine, Kansas State University
(to D.L.V.); and federal funds from the Frederick National Laboratory
for Cancer Research, NIH, under contract HHSN261200800001E with Leidos
Biomedical Research (Y.T.).
NR 24
TC 9
Z9 11
U1 27
U2 27
PU AMER ASSOC ADVANCEMENT SCIENCE
PI WASHINGTON
PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA
SN 0036-8075
EI 1095-9203
J9 SCIENCE
JI Science
PD OCT 14
PY 2016
VL 354
IS 6309
BP 237
EP 240
DI 10.1126/science.aai9137
PG 5
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA EC0UN
UT WOS:000387816500047
PM 27708058
ER
PT J
AU Deng, MG
Li, Z
Borodin, O
Karniadakis, GE
AF Deng, Mingge
Li, Zhen
Borodin, Oleg
Karniadakis, George Em
TI cDPD: A new dissipative particle dynamics method for modeling
electrokinetic phenomena at the mesoscale
SO JOURNAL OF CHEMICAL PHYSICS
LA English
DT Article
ID CAPILLARY-ELECTROPHORESIS; ELECTROOSMOTIC FLOW; DRIVEN FLOWS; TRANSPORT;
SIMULATIONS; ELECTROLYTES; MECHANICS; EQUATIONS; CHANNELS; FLUIDS
AB We develop a "charged" dissipative particle dynamics (cDPD) model for simulating mesoscopic electrokinetic phenomena governed by the stochastic Poisson-Nernst-Planck and the Navier-Stokes equations. Specifically, the transport equations of ionic species are incorporated into the DPD framework by introducing extra degrees of freedom and corresponding evolution equations associated with each DPD particle. Diffusion of ionic species driven by the ionic concentration gradient, electrostatic potential gradient, and thermal fluctuations is captured accurately via pairwise fluxes between DPD particles. The electrostatic potential is obtained by solving the Poisson equation on the moving DPD particles iteratively at each time step. For charged surfaces in bounded systems, an effective boundary treatment methodology is developed for imposing both the correct hydrodynamic and electrokinetics boundary conditions in cDPD simulations. To validate the proposed cDPD model and the corresponding boundary conditions, we first study the electrostatic structure in the vicinity of a charged solid surface, i.e., we perform cDPD simulations of the electrostatic double layer and show that our results are in good agreement with the well-known mean-field theoretical solutions. We also simulate the electrostatic structure and capacity densities between charged parallel plates in salt solutions with different salt concentrations. Moreover, we employ the proposed methodology to study the electro-osmotic and electro-osmotic/pressure-driven flows in a micro-channel. In the latter case, we simulate the dilute poly-electrolyte solution drifting by electro-osmotic flow in a micro-channel, hence demonstrating the flexibility and capability of this method in studying complex fluids with electrostatic interactions at the micro-and nano-scales. Published by AIP Publishing.
C1 [Deng, Mingge; Li, Zhen; Karniadakis, George Em] Brown Univ, Div Appl Math, Providence, RI 02912 USA.
[Borodin, Oleg] US Army Res Lab, Electrochem Branch, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA.
RP Li, Z (reprint author), Brown Univ, Div Appl Math, Providence, RI 02912 USA.
EM zhen_li@brown.edu; george_karniadakis@brown.edu
RI Li, Zhen/B-2722-2013
OI Li, Zhen/0000-0002-0936-6928
FU Collaboratory on Mathematics for Mesoscopic Modeling of Materials (CM4)
of DOE; Army Research Laboratory [W911NF-12-2-0023]; Innovative and
Novel Computational Impact on Theory and Experiment (INCITE) award
FX This work was sponsored by the Collaboratory on Mathematics for
Mesoscopic Modeling of Materials (CM4) of DOE and also by the Army
Research Laboratory and was accomplished under Cooperative Agreement No.
W911NF-12-2-0023. Computations were performed using an Innovative and
Novel Computational Impact on Theory and Experiment (INCITE) award with
resources of the Argonne Leadership Computing Facility and the Oak Ridge
Leadership Computing Facility. We would like to acknowledge Dr. Wenxiao
Pan from Pacific Northwest National Laboratory and Dr. Changho Kim from
Lawrence Berkeley National Laboratory for helpful discussions.
NR 53
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U1 15
U2 15
PU AMER INST PHYSICS
PI MELVILLE
PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA
SN 0021-9606
EI 1089-7690
J9 J CHEM PHYS
JI J. Chem. Phys.
PD OCT 14
PY 2016
VL 145
IS 14
AR 144109
DI 10.1063/1.4964628
PG 10
WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical
SC Chemistry; Physics
GA EA3VL
UT WOS:000386535900013
PM 27782504
ER
PT J
AU Chung, MK
White, PS
Lee, SJ
Gagne, MR
Waters, ML
AF Chung, Mee-Kyung
White, Peter S.
Lee, Stephen J.
Gagne, Michel R.
Waters, Marcey L.
TI Investigation of a Catenane with a Responsive Noncovalent Network:
Mimicking Long-Range Responses in Proteins
SO JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Article
ID LIGAND-BINDING ENERGY; ASSEMBLED MULTICOMPONENT CATENANES; DYNAMIC
COMBINATORIAL LIBRARIES; CH-PI INTERACTIONS; CATALYTIC EFFICIENCY; GUEST
BINDING; MOLECULAR RECOGNITION; SYNTHETIC RECEPTOR; SYSTEMS CHEMISTRY;
COOPERATIVITY
AB We report a functional synthetic model for studying the noncovalent networks (NCNs) required for complex protein functions. The model [2]-catenane is self-assembled from dipeptide building blocks and contains:an extensive network of hydrogen bonds and aromatic interactions. Perturbations to the catenane cause compensating changes in the NCNs structure and dynamics, resulting in long-distance changes reminiscent of a protein. Key findings include the notion that NCNs require regions of negative cooperativity, or "frustrated" noncovalent interactions, as a source of potential energy for driving the response. We refer to this potential energy as latent free energy and describe a mechanistic and energetic model for responsive systems.
C1 [Chung, Mee-Kyung; White, Peter S.; Gagne, Michel R.; Waters, Marcey L.] Univ N Carolina, Dept Chem, CB 3290, Chapel Hill, NC 27599 USA.
[Lee, Stephen J.] US Army Res Off, POB 12211, Res Triangle Pk, NC 27709 USA.
RP Gagne, MR; Waters, ML (reprint author), Univ N Carolina, Dept Chem, CB 3290, Chapel Hill, NC 27599 USA.
EM mgagne@unc.edu; mlwaters@unc.edu
FU NIH [GM110017]
FX S.J.L. acknowledges the Army Research Office, and M.-K.C. acknowledges
an NRC Research Associateship. M.R.G. and M.L.W. gratefully acknowledge
funding from the NIH (GM110017).
NR 40
TC 0
Z9 0
U1 14
U2 14
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0002-7863
J9 J AM CHEM SOC
JI J. Am. Chem. Soc.
PD OCT 12
PY 2016
VL 138
IS 40
BP 13344
EP 13352
DI 10.1021/jacs.6b07833
PG 9
WC Chemistry, Multidisciplinary
SC Chemistry
GA DY9QG
UT WOS:000385469600040
PM 27631725
ER
PT J
AU AbdulHameed, MDM
Ippolito, DL
Stallings, JD
Wallqvist, A
AF AbdulHameed, Mohamed Diwan M.
Ippolito, Danielle L.
Stallings, Jonathan D.
Wallqvist, Anders
TI Mining kidney toxicogenomic data by using gene co-expression modules
SO BMC GENOMICS
LA English
DT Article
DE Acute kidney injury; Toxicogenomics; Kidney co-expression modules; Gene
signature; Havcr1; KIM-1; Frequently co-expressed genes; AKI pathways;
Immunoproteasome; Cd44 ectodomain; AKI networks
ID ACUTE-RENAL-FAILURE; DRUG-INDUCED NEPHROTOXICITY; EXPRESSION DATA;
UP-REGULATION; R/BIOCONDUCTOR PACKAGE; MOLECULAR-MECHANISMS; INTERACTION
NETWORKS; SIGNALING PATHWAY; ISCHEMIC-INJURY; BIOMARKERS
AB Background: Acute kidney injury (AKI) caused by drug and toxicant ingestion is a serious clinical condition associated with high mortality rates. We currently lack detailed knowledge of the underlying molecular mechanisms and biological networks associated with AKI. In this study, we carried out gene co-expression analyses using DrugMatrix-a large toxicogenomics database with gene expression data from rats exposed to diverse chemicals-and identified gene modules associated with kidney injury to probe the molecular-level details of this disease.
Results: We generated a comprehensive set of gene co-expression modules by using the Iterative Signature Algorithm and found distinct clusters of modules that shared genes and were associated with similar chemical exposure conditions. We identified two module clusters that showed specificity for kidney injury in that they 1) were activated by chemical exposures causing kidney injury, 2) were not activated by other chemical exposures, and 3) contained known AKI-relevant genes such as Havcr1, Clu, and Tff3. We used the genes in these AKI-relevant module clusters to develop a signature of 30 genes that could assess the potential of a chemical to cause kidney injury well before injury actually occurs. We integrated AKI-relevant module cluster genes with protein-protein interaction networks and identified the involvement of immunoproteasomes in AKI. To identify biological networks and processes linked to Havcr1, we determined genes within the modules that frequently co-express with Havcr1, including Cd44, Plk2, Mdm2, Hnmt, Macrod1, and Gtpbp4. We verified this procedure by showing that randomized data did not identify Havcr1 co-expression genes and that excluding up to 10 % of the data caused only minimal degradation of the gene set. Finally, by using an external dataset from a rat kidney ischemic study, we showed that the frequently co-expressed genes of Havcr1 behaved similarly in a model of non-chemically induced kidney injury.
Conclusions: Our study demonstrated that co-expression modules and co-expressed genes contain rich information for generating novel biomarker hypotheses and constructing mechanism-based molecular networks associated with kidney injury.
C1 [AbdulHameed, Mohamed Diwan M.; Ippolito, Danielle L.; Stallings, Jonathan D.; Wallqvist, Anders] US Army, Dept Def Biotechnol High Performance Comp, Software Applicat Inst, Telemed & Adv Technol Res Ctr,Med Res & Mat Comma, 504 Scott St, Ft Detrick, MD 21702 USA.
RP Wallqvist, A (reprint author), US Army, Dept Def Biotechnol High Performance Comp, Software Applicat Inst, Telemed & Adv Technol Res Ctr,Med Res & Mat Comma, 504 Scott St, Ft Detrick, MD 21702 USA.
EM sven.a.wallqvist.civ@mail.mil
FU Military Operational Medicine Research Program, U.S. Army Medical
Research and Materiel Command (USAMRMC), Ft. Detrick, MD; U.S. Army's
Network Science Initiative, U.S. Army Medical Research and Materiel
Command (USAMRMC), Ft. Detrick, MD
FX The opinions and assertions contained herein are the private views of
the authors and are not to be construed as official or as reflecting the
views of the U.S. Army or of the U.S. Department of Defense. Citations
of commercial organizations or trade names in this report do not
constitute an official Department of the Army endorsement or approval of
the products or services of these organizations. This paper has been
approved for public release with unlimited distribution. The authors
were supported by the Military Operational Medicine Research Program and
the U.S. Army's Network Science Initiative, U.S. Army Medical Research
and Materiel Command (USAMRMC, http://mrmc.amedd.army.mil), Ft. Detrick,
MD.
NR 112
TC 1
Z9 1
U1 8
U2 8
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2164
J9 BMC GENOMICS
JI BMC Genomics
PD OCT 10
PY 2016
VL 17
AR 790
DI 10.1186/s12864-016-3143-y
PG 17
WC Biotechnology & Applied Microbiology; Genetics & Heredity
SC Biotechnology & Applied Microbiology; Genetics & Heredity
GA DY3IA
UT WOS:000384983100002
PM 27724849
ER
PT J
AU Franke, A
Hoffmann, MP
Kirste, R
Bobea, M
Tweedie, J
Kaess, F
Gerhold, M
Collazo, R
Sitar, Z
AF Franke, A.
Hoffmann, M. P.
Kirste, R.
Bobea, M.
Tweedie, J.
Kaess, F.
Gerhold, M.
Collazo, R.
Sitar, Z.
TI High reflectivity III-nitride UV-C distributed Bragg reflectors for
vertical cavity emitting lasers
SO JOURNAL OF APPLIED PHYSICS
LA English
DT Article
ID GAN; MICROCAVITIES; WAVELENGTHS; SAPPHIRE; MIRRORS; GROWTH; INDEX; FILMS
AB UV-C distributed Bragg reflectors (DBRs) for vertical cavity surface emitting laser applications and polariton lasers are presented. The structural integrity of up to 25 layer pairs of AlN/Al0.65Ga0.35N DBRs is maintained by balancing the tensile and compressive strain present between the single layers of the multilayer stack grown on top of an Al0.85Ga0.35N template. By comparing the structural and optical properties for DBRs grown on low dislocation density AlN and AlGaN templates, the criteria for plastic relaxation by cracking thick nitride Bragg reflectors are deduced. The critical thickness is found to be limited mainly by the accumulated strain energy during the DBR growth and is only negligibly affected by the dislocations. A reflectance of 97.7% at 273 nm is demonstrated. The demonstrated optical quality and an ability to tune the resonance wavelength of our resonators and microcavity structures open new opportunities for UV-C vertical emitters. Published by AIP Publishing.
C1 [Franke, A.; Hoffmann, M. P.; Bobea, M.; Kaess, F.; Collazo, R.; Sitar, Z.] North Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA.
[Kirste, R.; Tweedie, J.] Adroit Mat Inc, 2054 Kildaire Farm Rd,Suite 205, Cary, NC 27518 USA.
[Gerhold, M.] Army Res Off, Engn Sci Directorate, POB 12211, Res Triangle Pk, NC 27703 USA.
RP Franke, A (reprint author), North Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA.
FU U.S. Army Research Office [W911NF-15-2-0068]; NRC at the U.S. Army
Research Office
FX This research was supported by the U.S. Army Research Office within the
Cooperative Agreement: W911NF-15-2-0068. Within the agreement, the
authors held an NRC Research Associateship award at the U.S. Army
Research Office. We are grateful to Christopher Shelton (North Carolina
State University) for his support with Ellipsometry measurements.
NR 26
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U1 12
U2 12
PU AMER INST PHYSICS
PI MELVILLE
PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA
SN 0021-8979
EI 1089-7550
J9 J APPL PHYS
JI J. Appl. Phys.
PD OCT 7
PY 2016
VL 120
IS 13
AR 135703
DI 10.1063/1.4963831
PG 5
WC Physics, Applied
SC Physics
GA DZ8XE
UT WOS:000386155100043
ER
PT J
AU Xu, K
Wang, CS
AF Xu, Kang
Wang, Chunsheng
TI Widening voltage windows
SO NATURE ENERGY
LA English
DT Editorial Material
ID ION BATTERIES; ELECTROLYTES; LI
C1 [Xu, Kang] US Army Res Lab, Electrochem Branch, Adelphi, MD 20783 USA.
[Wang, Chunsheng] Univ Maryland, Dept Chem & Biomol Engn, College Pk, MD 20740 USA.
RP Xu, K (reprint author), US Army Res Lab, Electrochem Branch, Adelphi, MD 20783 USA.
EM conrad.k.xu.civ@mail.mil; cswang@umd.edu
NR 6
TC 0
Z9 0
U1 1
U2 1
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2058-7546
J9 NAT ENERGY
JI Nat. Energy
PD OCT 6
PY 2016
VL 1
AR 16161
DI 10.1038/NENERGY.2016.161
PG 2
WC Energy & Fuels; Materials Science, Multidisciplinary
SC Energy & Fuels; Materials Science
GA EL7HC
UT WOS:000394790700004
ER
PT J
AU Gardea, F
Glaz, B
Riddick, J
Lagoudas, DC
Naraghi, M
AF Gardea, Frank
Glaz, Bryan
Riddick, Jaret
Lagoudas, Dimitris C.
Naraghi, Mohammad
TI Thermally activated energy dissipation in semi-crystalline polymer
nanocomposites
SO COMPOSITES SCIENCE AND TECHNOLOGY
LA English
DT Article
DE Active damping; Viscoelastic damping; Nanocomposites; PEEK
ID CARBON NANOTUBE COMPOSITES; POLY(ETHER ETHER KETONE);
POLY(ETHERETHERKETONE) PEEK; CRYSTALLIZATION; TRANSITION; BEHAVIOR
AB In this manuscript, we demonstrate the concept of active damping in semi-crystalline thermoplastics which are reinforced with a percolated network of CNTs, where the damping of the composite was augmented considerably, controllably and reversibly via Joule heating. The Joule heating triggered relaxation mechanisms in the amorphous phase of the matrix. To this end, semi-crystalline poly ether ether ketone (PEEK) polymer and PEEK/carbon nanotube (CNT) composites were fabricated and their viscoelastic properties were studied. The damping performance was experimentally tested by dynamic mechanical analysis. The polymer relaxation resulting from an increase in temperature, triggered by the Joule heating of the nanoparticles, demonstrated the potential for damping enhancement in the composite. A considerable enhancement in damping (by as much as 400%) was achieved at a significantly lower relative loss in storage modulus (40%), both caused by relaxation mechanisms in Joule heated samples. This enhancement in damping corresponds to a 150% improvement in the figure of merit for damping materials. The non-uniform temperature distribution in the sample was measured experimentally at the macroscale and estimated via continuum models at the microscale. It was concluded that non-uniform temperature distribution in the composite, especially at the microscale, had a large effect on the overall damping enhancement. Based on the microscale models, potential mechanisms by which the active damping can be enhanced were discussed. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Gardea, Frank; Lagoudas, Dimitris C.; Naraghi, Mohammad] Texas A&M Univ, Dept Aerosp Engn, 3409 TAMU, College Stn, TX 77843 USA.
[Glaz, Bryan; Riddick, Jaret] US Army Res Lab, Vehicle Technol Directorate, Aberdeen Proving Ground, MD 21005 USA.
RP Naraghi, M (reprint author), Texas A&M Univ, Dept Aerosp Engn, 3409 TAMU, College Stn, TX 77843 USA.
EM naraghi@aero.tamu.edu
FU DOD-Army Research Laboratory [W911NF-14-2-0080]
FX The authors would like to thank Dr. Hung-Jue Sue at Texas A&M University
for providing the neat PEEK material. In addition, M.N. and D.C.L. would
like to acknowledge the support of DOD-Army Research Laboratory under
the award No. W911NF-14-2-0080. The use of the TAMU Materials
Characterization Facility for SEM imaging is acknowledged.
NR 34
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Z9 0
U1 5
U2 5
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0266-3538
EI 1879-1050
J9 COMPOS SCI TECHNOL
JI Compos. Sci. Technol.
PD OCT 6
PY 2016
VL 134
BP 275
EP 286
DI 10.1016/j.compscitech.2016.08.025
PG 12
WC Materials Science, Composites
SC Materials Science
GA DY1QC
UT WOS:000384868500032
ER
PT J
AU Margolis, LM
Rivas, DA
Berrone, M
Ezzyat, Y
Young, AJ
McClung, JP
Fielding, RA
Pasiakos, SM
AF Margolis, Lee M.
Rivas, Donato A.
Berrone, Maria
Ezzyat, Yassine
Young, Andrew J.
McClung, James P.
Fielding, Roger A.
Pasiakos, Stefan M.
TI Prolonged Calorie Restriction Downregulates Skeletal Muscle mTORC1
Signaling Independent of Dietary Protein Intake and Associated microRNA
Expression
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Article
DE muscle protein content; energy deficit; rpS6; miR-99; miR-100
ID RESISTANCE EXERCISE; SHORT-TERM; TRANSPORTER EXPRESSION; HYPERTROPHY;
REPRESSION; INGESTION; INCREASE; LEUCINE; TARGET; BONE
AB Short-term (5-10 days) calorie restriction (CR) downregulates muscle protein synthesis, with consumption of a high protein-based diet attenuating this decline. Benefit of increase protein intake is believed to be due to maintenance of amino acid-mediated anabolic signaling through the mechanistic target of rapamycin complex 1 (mTORC1), however, there is limited evidence to support this contention. The purpose of this investigation was to determine the effects of prolonged CR and high protein diets on skeletal muscle mTORC1 signaling and expression of associated microRNA (miR). Twelve-week old male Sprague Dawley rats consumed ad libitum (AL) or calorie restricted (CR; 40%) adequate (10%, AIN-93M) or high (32%) protein milk-based diets for 16 weeks. Body composition was determined using dual energy X-ray absorptiometry and muscle protein content was calculated from muscle homogenate protein concentrations expressed relative to fat-free mass to estimate protein content. Western blot and RT-qPCR were used to determine mTORC1 signaling and mRNA and miR expression in fasted mixed gastrocnemius. Independent of dietary protein intake, muscle protein content was 38% lower (P < 0.05) in CR compared to AL. Phosphorylation and total Akt, mTOR, rpS6, and p70S6K were lower (P < 0.05) in CR vs. AL, and total rpS6 was associated with muscle protein content (r = 0.64, r(2) = 0.36). Skeletal muscle miR expression was not altered by either energy or protein intake. This study provides evidence that chronic CR attenuates muscle protein content by downregulating mTORC1 signaling. This response is independent of skeletal muscle miR and dietary protein.
C1 [Margolis, Lee M.; Rivas, Donato A.; Berrone, Maria; Ezzyat, Yassine; Fielding, Roger A.] Tufts Univ, Jean Mayer Human Nutr Res Ctr Aging, USDA, Nutr Exercise Physiol & Sarcopenia Lab, Boston, MA 02111 USA.
[Margolis, Lee M.; Young, Andrew J.; McClung, James P.; Pasiakos, Stefan M.] US Army, Mil Nutr Div, Environm Med Res Inst, Natick, MA 01760 USA.
RP Pasiakos, SM (reprint author), US Army, Mil Nutr Div, Environm Med Res Inst, Natick, MA 01760 USA.
EM stefan.m.pasiakos.civ@mail.mil
RI Pasiakos, Stefan/E-6295-2014;
OI Pasiakos, Stefan/0000-0002-5378-5820; Rivas, Donato/0000-0002-4500-6233;
, Lee/0000-0002-0652-1304
FU US Army Medical Research and Material Command; Dairy Research Institute;
USDA [58-1950-4-003]; T32 NIDDK training grant [5T32DK062032-23]; NIA
[KAG047247A-A1]
FX This material is based on the work supported by the US Army Medical
Research and Material Command, the Dairy Research Institute, and the
USDA under agreement No. 58-1950-4-003. LM was supported by the T32
NIDDK training grant # 5T32DK062032-23 and DR was supported by the NIA
K01 award # KAG047247A-A1.
NR 35
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U1 9
U2 9
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015,
SWITZERLAND
SN 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD OCT 5
PY 2016
VL 7
AR 445
DI 10.3389/fphys.2016.00445
PG 11
WC Physiology
SC Physiology
GA DX9CD
UT WOS:000384690000001
PM 27761114
ER
PT J
AU Mellon, J
Yoder, J
Evans, D
AF Mellon, Jonathan
Yoder, Jordan
Evans, Daniel
TI Undermining and Strengthening Social Networks through Network
Modification
SO SCIENTIFIC REPORTS
LA English
DT Article
ID RANDOM GRAPH MODELS; FIRM PERFORMANCE; INDUSTRY
AB Social networks have well documented effects at the individual and aggregate level. Consequently it is often useful to understand how an attempt to influence a network will change its structure and consequently achieve other goals. We develop a framework for network modification that allows for arbitrary objective functions, types of modification (e.g. edge weight addition, edge weight removal, node removal, and covariate value change), and recovery mechanisms (i.e. how a network responds to interventions). The framework outlined in this paper helps both to situate the existing work on network interventions but also opens up many new possibilities for intervening in networks. In particular use two case studies to highlight the potential impact of empirically calibrating the objective function and network recovery mechanisms as well as showing how interventions beyond node removal can be optimised. First, we simulate an optimal removal of nodes from the Noordin terrorist network in order to reduce the expected number of attacks (based on empirically predicting the terrorist collaboration network from multiple types of network ties). Second, we simulate optimally strengthening ties within entrepreneurial ecosystems in six developing countries. In both cases we estimate ERGM models to simulate how a network will endogenously evolve after intervention.
C1 [Mellon, Jonathan; Yoder, Jordan; Evans, Daniel] US Mil Acad, Network Sci Ctr, West Point, NY 10996 USA.
[Mellon, Jonathan] Univ Oxford, Nuffield Coll, Oxford, England.
[Yoder, Jordan] Johns Hopkins Univ, Appl Math & Stat, Baltimore, MD 21218 USA.
RP Yoder, J (reprint author), US Mil Acad, Network Sci Ctr, West Point, NY 10996 USA.; Yoder, J (reprint author), Johns Hopkins Univ, Appl Math & Stat, Baltimore, MD 21218 USA.
EM jyoder6@jhu.edu
FU U.S. Army Studies Program; U.S. Army Research Office
FX This research was funded in part by the U.S. Army Studies Program and
the U.S. Army Research Office. The authors are participants in the
Scientific Services Program administered by the Battelle Memorial
Institute.
NR 32
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U1 11
U2 11
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD OCT 5
PY 2016
VL 6
BP 1
EP 10
AR 34613
DI 10.1038/srep34613
PG 10
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA DX8XX
UT WOS:000384676300001
PM 27703198
ER
PT J
AU Mittendorf, EA
Ardavanis, A
Litton, JK
Shumway, NM
Hale, DF
Murray, JL
Perez, SA
Ponniah, S
Baxevanis, CN
Papamichail, M
Peoples, GE
AF Mittendorf, Elizabeth A.
Ardavanis, Alexandros
Litton, Jennifer K.
Shumway, Nathan M.
Hale, Diane F.
Murray, James L.
Perez, Sonia A.
Ponniah, Sathibalan
Baxevanis, Constantin N.
Papamichail, Michael
Peoples, George E.
TI Primary analysis of a prospective, randomized, single-blinded phase II
trial evaluating the HER2 peptide GP2 vaccine in breast cancer patients
to prevent recurrence
SO ONCOTARGET
LA English
DT Article
DE vaccine; cytotoxic T lymphocytes; breast cancer; HER2; trastuzumab
ID GROUP-STUDY I-01; CLINICAL-TRIAL; HER2/NEU-DERIVED PEPTIDE; BOOSTER
INOCULATIONS; DENDRITIC CELLS; IN-VIVO; HER-2/NEU; RESPONSES;
IMMUNOTHERAPY; TRASTUZUMAB
AB GP2 is a HER2-derived, HLA-A2+ restricted peptide. Phase I studies showed GP2 administered with GM-CSF to be safe and immunogenic. Here we report the primary analysis of a prospective, randomized, multicenter phase II adjuvant trial conducted to determine the vaccine's efficacy. The trial enrolled HLA-A2+, clinically disease-free, node-positive and high-risk node-negative breast cancer patients with tumors expressing HER2 (immunohistochemistry[ IHC] 1+-3+). Patients were randomized to GP2+ GM-CSF versus GM-CSF alone. Disease-free survival (DFS) was analyzed in intention-to-treat (ITT) and per-treatment cohorts; pre-specified subgroup analyses were performed for patients with IHC 3+ or FISH+ disease. The trial enrolled 180 patients; 89 received GP2+ GM-CSF and 91 received GM-CSF alone. The groups were well-matched for clinicopathologic characteristics. Toxicities have been minimal. The Kaplan-Meier estimated 5-year DFS rate in the ITT analyses was 88% (95% CI: 78-94%) in vaccinated vs. 81% (95% CI: 69-89%) (P = 0.43) in control patients after a 34 month median follow-up. In the per-treatment analysis, the estimated 5-year DFS rates were 94% (95% CI: 83-98%) and 85% (73-92%) (P = 0.17). In IHC 3+/ FISH+ patients, the estimated 5-year DFS rate was 94% (82-98%) in vaccinated patients (n = 51) vs. 89% (71-96%) in control patients (n = 50), (P = 0.86) in the ITT analyses and 100% vs. 89% (71-96%) in vaccinated vs. control patients in the per-treatment analyses (P = 0.08). While the overall ITT analysis did not demonstrate benefit to vaccination, this trial confirmed that the GP2 vaccine is safe and suggests that vaccination may have clinical activity, particularly in patients with HER2 overexpression who received the full vaccine series (ie per-treatment group).
C1 [Mittendorf, Elizabeth A.] Univ Texas MD Anderson Canc Ctr, Dept Breast Surg Oncol, Houston, TX 77030 USA.
[Ardavanis, Alexandros; Perez, Sonia A.; Baxevanis, Constantin N.; Papamichail, Michael] St Savas Canc Hosp, Canc Immunol & Immunotherapy Ctr, Athens, Greece.
[Litton, Jennifer K.; Murray, James L.] Univ Texas MD Anderson Canc Ctr, Dept Breast Med Oncol, Houston, TX 77030 USA.
[Shumway, Nathan M.] Brooke Army Med Ctr, Dept Hematol Oncol, Ft Sam Houston, TX 78234 USA.
[Hale, Diane F.] Brooke Army Med Ctr, Dept Surg, Ft Sam Houston, TX 78234 USA.
[Ponniah, Sathibalan] Uniformed Serv Univ Hlth Sci, Dept Surg, Canc Vaccine Dev Lab, Bethesda, MD 20814 USA.
[Peoples, George E.] Canc Vaccine Dev Program, San Antonio, TX USA.
RP Mittendorf, EA (reprint author), Univ Texas MD Anderson Canc Ctr, Dept Breast Surg Oncol, Houston, TX 77030 USA.; Peoples, GE (reprint author), Canc Vaccine Dev Program, San Antonio, TX USA.
EM eamitten@mdanderson.org; georgepeoples2@hotmail.com
FU Norwell, Inc.; Henry M Jackson Foundation; United States Military Cancer
Institute, Department of Surgery, Uniformed Services University of the
Health Sciences; Department of Clinical Investigation, Walter Reed Army
Medical Center; Jeanne F. Shelby Scholarship Fund; National Institutes
of Health [CA016672]
FX This work was primarily funded by a grant to George E. Peoples from
Norwell, Inc. and the Henry M Jackson Foundation. Additional funding was
provided by the United States Military Cancer Institute, Department of
Surgery, Uniformed Services University of the Health Sciences; and the
Department of Clinical Investigation, Walter Reed Army Medical Center.
Elizabeth A. Mittendorf is a R. Lee Clark Fellow of The University of
Texas MD Anderson Cancer Center supported by the Jeanne F. Shelby
Scholarship Fund. This study was conducted in part at the University of
Texas MD Anderson Cancer Center which is supported by the National
Institutes of Health Grant CA016672. Funding sources were not involved
with the study design; in the collection, analysis, or interpretation of
data; in the writing of the report; or in the decision to submit the
paper for publication.
NR 20
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U1 1
U2 1
PU IMPACT JOURNALS LLC
PI ALBANY
PA 6211 TIPTON HOUSE, STE 6, ALBANY, NY 12203 USA
SN 1949-2553
J9 ONCOTARGET
JI Oncotarget
PD OCT 4
PY 2016
VL 7
IS 40
BP 66192
EP 66201
DI 10.18632/oncotarget.11751
PG 10
WC Oncology; Cell Biology
SC Oncology; Cell Biology
GA EB3QQ
UT WOS:000387281000130
PM 27589688
ER
PT J
AU Fabbri, F
Rotunno, E
Cinquanta, E
Campi, D
Bonnini, E
Kaplan, D
Lazzarini, L
Bernasconi, M
Ferrari, C
Longo, M
Nicotra, G
Molle, A
Swaminathan, V
Salviati, G
AF Fabbri, F.
Rotunno, E.
Cinquanta, E.
Campi, D.
Bonnini, E.
Kaplan, D.
Lazzarini, L.
Bernasconi, M.
Ferrari, C.
Longo, M.
Nicotra, G.
Molle, A.
Swaminathan, V.
Salviati, G.
TI Novel near-infrared emission from crystal defects in MoS2 multilayer
flakes
SO NATURE COMMUNICATIONS
LA English
DT Article
ID SINGLE-LAYER MOS2; MONOLAYER MOS2; MOLYBDENUM-DISULFIDE;
PHOTOLUMINESCENCE
AB The structural defects in two-dimensional transition metal dichalcogenides, including point defects, dislocations and grain boundaries, are scarcely considered regarding their potential to manipulate the electrical and optical properties of this class of materials, notwithstanding the significant advances already made. Indeed, impurities and vacancies may influence the exciton population, create disorder-induced localization, as well as modify the electrical behaviour of the material. Here we report on the experimental evidence, confirmed by ab initio calculations, that sulfur vacancies give rise to a novel near-infrared emission peak around 0.75 eV in exfoliated MoS2 flakes. In addition, we demonstrate an excess of sulfur vacancies at the flake's edges by means of cathodoluminescence mapping, aberration-corrected transmission electron microscopy imaging and electron energy loss analyses. Moreover, we show that ripplocations, extended line defects peculiar to this material, broaden and redshift the MoS2 indirect bandgap emission.
C1 [Fabbri, F.; Rotunno, E.; Bonnini, E.; Lazzarini, L.; Ferrari, C.; Salviati, G.] IMEM CNR Inst, Parco Area Sci 37-A, I-43124 Parma, Italy.
[Fabbri, F.] Italian Space Agcy, KET Lab, Via Politecn, I-00133 Rome, Italy.
[Cinquanta, E.; Longo, M.; Molle, A.] IMM CNR, Lab MDM, Via C Olivetti 2, I-20864 Agrate Brianza, Italy.
[Campi, D.; Bernasconi, M.] Univ Milano Bicocca, Dipartimento Sci Mat, Via R Cozzi 55, I-20126 Milan, Italy.
[Kaplan, D.; Swaminathan, V.] US Army RDECOM ARDEC, Fuze Precis Armaments & Technol Directorate, Picatinny Arsenal, NJ 07806 USA.
[Nicotra, G.] IMM CNR Inst, Str 8, I-95121 Catania, Italy.
RP Salviati, G (reprint author), IMEM CNR Inst, Parco Area Sci 37-A, I-43124 Parma, Italy.
EM giancarlo.salviati@cnr.it
RI Nicotra, Giuseppe/R-6038-2016;
OI Nicotra, Giuseppe/0000-0002-7336-4898; Longo,
Massimo/0000-0002-6364-8184; Molle, Alessandro/0000-0002-3860-4120
FU U.S. Army [W911NF-14-1-0612]; European Project SYNAPSE; Project
BioNiMed; MIUR [PON a3_00363]
FX This work is partly supported by the U.S. Army Contract
W911NF-14-1-0612, by the European Project SYNAPSE and by the Project
BioNiMed. Part of this work has been performed at Beyondnano CNR-IMM,
Catania, Italy, which is supported by the MIUR under project Beyond-Nano
(PON a3_00363). A.M. and E.C. acknowledge Dr C. Martella (CNR-IMM) for
his support in the analysis of the Raman maps.
NR 25
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PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2041-1723
J9 NAT COMMUN
JI Nat. Commun.
PD OCT 4
PY 2016
VL 7
AR 13044
DI 10.1038/ncomms13044
PG 7
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA DZ1CJ
UT WOS:000385576100001
PM 27698425
ER
PT J
AU Rowan, MP
Beckman, DJ
Rizzo, JA
Isbell, CL
White, CE
Cohn, SM
Chung, KK
AF Rowan, Matthew P.
Beckman, Darrick J.
Rizzo, Julie A.
Isbell, Claire L.
White, Christopher E.
Cohn, Stephen M.
Chung, Kevin K.
TI Elevations in growth hormone and glucagon-like peptide-2 levels on
admission are associated with increased mortality in trauma patients
SO SCANDINAVIAN JOURNAL OF TRAUMA RESUSCITATION & EMERGENCY MEDICINE
LA English
DT Article
DE Biomarker; Burn; Hormone; Hypermetabolism; Trauma
ID SEVERELY BURNED CHILDREN; CRITICAL ILLNESS; FACTOR-I;
PARENTERAL-NUTRITION; THERMAL-INJURY; THERAPY; PROTEIN; AXIS; ADULTS;
HYPERMETABOLISM
AB Background: Burn and trauma patients present a clinical challenge due to metabolic derangements and hypermetabolism that result in a prolonged catabolic state with impaired healing and secondary complications, including ventilator dependence. Previous work has shown that circulating levels of growth hormone (GH) are predictive of mortality in critically ill adults, but few studies have examined the prognostic potential of GH levels in adult trauma patients.
Methods: To investigate the utility of GH and other endocrine responses in the prediction of outcomes, we conducted a prospective, observational study of adult burn and trauma patients. We evaluated the serum concentration of GH, insulinlike growth factor 1 (IGF-1), IGF binding protein 3 (IGFBP-3), and glucagon-like peptide-2 (GLP-2) weekly for up to 6 weeks in 36 adult burn and trauma patients admitted between 2010 and 2013.
Results: Non-survivors had significantly higher levels of GH and GLP-2 on admission than survivors.
Discussion: This study demonstrates that GH has potential as a predictor of mortality in critically ill trauma and burn patients. Future studies will focus on not only the role of GH, but also GLP-2, which was shown to correlate with mortality in this study with a goal of offering early, targeted therapeutic interventions aimed at decreasing mortality in the critically injured.
Conclusions: GH and GLP-2 may have clinical utility for outcome prediction in adult trauma patients.
C1 [Rowan, Matthew P.; Rizzo, Julie A.; Chung, Kevin K.] US Army Inst Surg Res, JBSA, 3698 Chambers Pass, San Antonio, TX 78234 USA.
[Beckman, Darrick J.; White, Christopher E.] Brooke Army Med Ctr, JBSA, 3855 Roger Brooke Dr, San Antonio, TX 78234 USA.
[Rizzo, Julie A.; Chung, Kevin K.] Uniformed Serv Univ Hlth Sci, 4301 Jones Bridge Rd A3007, Bethesda, MD 20814 USA.
[Isbell, Claire L.] Baylor Scott & White Mem Hosp, 2401 S 31st St, Temple, TX 76502 USA.
[Cohn, Stephen M.] Staten Isl Univ Hosp, 475 Seaview Ave, Staten Isl, NY 10305 USA.
RP Rizzo, JA (reprint author), US Army Inst Surg Res, JBSA, 3698 Chambers Pass, San Antonio, TX 78234 USA.; Rizzo, JA (reprint author), Uniformed Serv Univ Hlth Sci, 4301 Jones Bridge Rd A3007, Bethesda, MD 20814 USA.
EM julie.a.rizzo.mil@mail.mil
FU U.S. Department of Energy; USAMRMC
FX This work was supported in part by an appointment (MPR) to the
Postgraduate Research Participation Program at the U.S. Army Institute
of Surgical Research administered by the Oak Ridge Institute for Science
and Education through an interagency agreement between the U.S.
Department of Energy and USAMRMC.
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PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1757-7241
J9 SCAND J TRAUMA RESUS
JI Scand. J. Trauma Resusc. Emerg. Med.
PD OCT 4
PY 2016
VL 24
AR 119
DI 10.1186/s13049-016-0310-8
PG 6
WC Emergency Medicine
SC Emergency Medicine
GA DY2VM
UT WOS:000384950200005
PM 27716276
ER
PT J
AU Anders, MA
Lenahan, PM
Lelis, AJ
AF Anders, M. A.
Lenahan, P. M.
Lelis, A. J.
TI Are dangling bond centers important interface traps in 4H-SiC metal
oxide semiconductor field effect transistors?
SO APPLIED PHYSICS LETTERS
LA English
DT Article
ID SPIN-DEPENDENT RECOMBINATION; MOS-TRANSISTORS; CARBIDE; PASSIVATION;
NITRIDATION; STATES
AB Silicon carbide (SiC) based metal-oxide-semiconductor field-effect transistors (MOSFETs) have great promise in high power and high temperature applications. Unfortunately, effective channel mobilities remain disappointingly low, typically about 30 cm(2)/Vs. A major contributor to the disappointing effective channel mobilities is the presence of substantial densities of interface traps at the SiC/SiO2 interface. Many investigators have invoked silicon or carbon dangling bonds to be the dominating source of these interface defects, but very little, if any, direct experimental evidence exists to support this assumption in the SiC/SiO2 system. Cantin et al. [Phys. Rev. Lett. 92, 1 (2004)] have used conventional electron paramagnetic resonance measurements on porous oxidized SiC structures to measure the g tensor for the SiC/SiO2 interface carbon dangling bond. These results provide a particularly straightforward means to search for the presence of carbon dangling bonds in fully processed SiC MOSFETs using electrically detected magnetic resonance. Additionally, simple theory provides guidance to search for silicon dangling bond defects. In this study, we utilize K band electrically detected magnetic resonance via spin dependent charge pumping measurements in which almost all of the SiC band gap at the SiC/SiO2 interface is accessed. Although quite high signal to noise measurements are achieved, we are unable to detect any trace of the carbon dangling bond spectra. However, in very poor quality p-channel devices, we observe a spectrum which could be consistent with silicon dangling bonds. Other defect centers are clearly present and we conclude that these other centers dominate the interface trap density of states. Published by AIP Publishing.
C1 [Anders, M. A.; Lenahan, P. M.] Penn State Univ, Intercoll Program Mat, University Pk, PA 16802 USA.
[Lenahan, P. M.] Penn State Univ, Dept Engn Sci & Mech, 227 Hammond Bldg, University Pk, PA 16802 USA.
[Lelis, A. J.] US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
RP Anders, MA (reprint author), Penn State Univ, Intercoll Program Mat, University Pk, PA 16802 USA.
FU U.S. Army Research Laboratory
FX This work at Penn State was supported by the U.S. Army Research
Laboratory. Any opinions, findings, conclusions, or other
recommendations expressed herein are those of the authors and do not
necessarily reflect the views of the U.S. Army Research Laboratory.
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PI MELVILLE
PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA
SN 0003-6951
EI 1077-3118
J9 APPL PHYS LETT
JI Appl. Phys. Lett.
PD OCT 3
PY 2016
VL 109
IS 14
AR 142106
DI 10.1063/1.4963708
PG 5
WC Physics, Applied
SC Physics
GA DZ8WJ
UT WOS:000386152800025
ER
PT J
AU Pickle, NT
Wilken, JM
Whitehead, JMA
Silverman, AK
AF Pickle, Nathaniel T.
Wilken, Jason M.
Whitehead, Jennifer M. Aldridge
Silverman, Anne K.
TI Whole-body angular momentum during sloped walking using passive and
powered lower-limb prostheses
SO JOURNAL OF BIOMECHANICS
LA English
DT Article
DE Biomechanics; Uphill; Downhill; Amputee; Falls; Dynamic balance
ID KNEE AMPUTEE GAIT; TRANSTIBIAL AMPUTATION; STAIR ASCENT; BIOMECHANICS;
MUSCLE; ADAPTATION; KINEMATICS; SURFACES; KINETICS; SYSTEM
AB Sloped walking requires altered strategies for maintaining dynamic balance relative to level-ground walking, as evidenced by changes in sagittal-plane whole-body angular momentum (H) in able-bodied individuals. The ankle plantarflexor muscles are critical for regulating H, and functional loss of these muscles from transtibial amputation affects this regulation. However, it is unclear if a powered prosthesis, which more closely emulates intact ankle function than a passive energy-storage-and-return prosthesis, affects H differently during sloped walking. Therefore, our purpose was to investigate H in individuals with unilateral transtibial amputation when using powered and passive prostheses. Overall, the range of H was greater in people with a transtibial amputation relative to able-bodied individuals. On a 10 decline, individuals with amputation did not decrease H as much as able-bodied individuals, and had reduced prosthetic limb braking ground reaction forces and knee power absorption. On a +10 degrees incline, individuals with amputation had a greater relative increase of H than able-bodied individuals, a more anterior placement of the prosthetic foot, and higher peak hip power generation. The powered prosthesis condition resulted in a smaller range of H during prosthetic stance relative to the passive condition, although it was still larger than able-bodied individuals. Our results suggest that prosthetic ankle power generation may help regulate dynamic balance during prosthetic stance, but alone is not sufficient for restoring H to that of able-bodied individuals on slopes. Contributions of knee extensor muscles and the biarticular gastrocnemius in regulating H on slopes should be further investigated. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Pickle, Nathaniel T.; Silverman, Anne K.] Colorado Sch Mines, Dept Mech Engn, Golden, CO 80401 USA.
[Wilken, Jason M.; Whitehead, Jennifer M. Aldridge] Brooke Army Med Ctr, Dept Orthopaed & Rehabil, Ctr Intrepid, Jbsa Ft Sam Houston, TX 78234 USA.
RP Silverman, AK (reprint author), Colorado Sch Mines, Dept Mech Engn, Golden, CO 80401 USA.
EM asilverm@mines.edu
OI Silverman, Anne/0000-0002-2228-4548
FU Eunice Kennedy Shriver National Institute of Child Health & Human
Development of the National Institutes of Health [R03HD075946]; Center
for Rehabilitation Sciences Research, Department of Physical Medicine
and Rehabilitation, Uniformed Services University of Health Sciences,
Bethesda, MD
FX Research reported in this publication was supported by the Eunice
Kennedy Shriver National Institute of Child Health & Human Development
of the National Institutes of Health under Award number R03HD075946. The
content is solely the responsibility of the authors and does not
necessarily represent the official views of the National Institutes of
Health. The views expressed herein are those of the authors and do not
reflect the official policy or position of San Antonio Military Medical
Center, the U.S. Army Medical Department, the U.S. Army Office of the
Surgeon General, the Department of the Army, Department of Defense
and/or the U.S. Government. Additional support was provided by the
Center for Rehabilitation Sciences Research, Department of Physical
Medicine and Rehabilitation, Uniformed Services University of Health
Sciences, Bethesda, MD. The authors would also like to acknowledge
Audrey Westbrook and Kelly Ohm for their extensive contributions in data
processing.
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PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0021-9290
EI 1873-2380
J9 J BIOMECH
JI J. Biomech.
PD OCT 3
PY 2016
VL 49
IS 14
BP 3397
EP 3406
DI 10.1016/j.jbiomech.2016.09.010
PG 10
WC Biophysics; Engineering, Biomedical
SC Biophysics; Engineering
GA EA9SG
UT WOS:000386984400036
PM 27670646
ER
PT J
AU O'Hearn, AE
Voorhees, MA
Fetterer, DP
Wauquier, N
Coomber, MR
Bangura, J
Fair, JN
Gonzalez, JP
Schoepp, RJ
AF O'Hearn, Aileen E.
Voorhees, Matthew A.
Fetterer, David P.
Wauquier, Nadia
Coomber, Moinya R.
Bangura, James
Fair, Joseph N.
Gonzalez, Jean-Paul
Schoepp, Randal J.
TI Serosurveillance of viral pathogens circulating in West Africa
SO VIROLOGY JOURNAL
LA English
DT Article
DE Serosurvey; West Africa; Sierra Leone; Lassa; Ebola; Marburg; Rift
Valley fever; Crimean-Congo; Alphavirus; Flavivirus; Prevalence;
Antibodies; IgG; MAGPIX; Luminex
ID CONGO HEMORRHAGIC-FEVER; RIFT-VALLEY FEVER; S-GENOME RNA; SIERRA-LEONE;
LASSA FEVER; VIRUS-DISEASE; MONOCLONAL-ANTIBODIES; ARBOVIRAL INFECTIONS;
NUCLEOTIDE-SEQUENCE; YELLOW-FEVER
AB Background: Sub-Saharan Africa is home to a variety of pathogens, but disease surveillance and the healthcare infrastructure necessary for proper management and control are severely limited. Lassa virus, the cause of Lassa fever, a severe hemorrhagic fever in humans is endemic in West Africa. In Sierra Leone at the Kenema Government Hospital Lassa Diagnostic Laboratory, up to 70 % of acute patient samples suspected of Lassa fever test negative for Lassa virus infection. This large amount of acute undiagnosed febrile illness can be attributed in part to an array of hemorrhagic fever and arthropod-borne viruses causing disease that goes undetected and untreated.
Methods: To better define the nature and extent of viral pathogens infecting the Sierra Leonean population, we developed a multiplexed MAGPIX (R) assay to detect IgG antibodies against Lassa, Ebola, Marburg, Rift Valley fever, and Crimean-Congo hemorrhagic fever viruses as well as pan-assays for flaviviruses and alphaviruses. This assay was used to survey 675 human serum samples submitted to the Lassa Diagnostic Laboratory between 2007 and 2014.
Results: In the study population, 50.2 % were positive for Lassa virus, 5.2 % for Ebola virus, 10.7 % for Marburg virus, 1.8 % for Rift Valley fever virus, 2.0 % for Crimean-Congo hemorrhagic fever virus, 52.9 % for flaviviruses and 55.8 % for alphaviruses.
Conclusions: These data exemplify the importance of disease surveillance and differential diagnosis for viral diseases in Sierra Leone. We demonstrate the endemic nature of some of these viral pathogens in the region and suggest that unrecognized outbreaks of viral infection have occurred.
C1 [O'Hearn, Aileen E.; Voorhees, Matthew A.; Schoepp, Randal J.] US Army, Med Res Inst Infect Dis, Diagnost Syst Div, 1425 Porter St, Ft Detrick, MD 21702 USA.
[Fetterer, David P.] US Army, Med Res Inst Infect Dis, Div Stat, Ft Detrick, MD 21702 USA.
[Wauquier, Nadia; Bangura, James; Gonzalez, Jean-Paul] Metabiota Inc, San Francisco, CA USA.
[Coomber, Moinya R.] Kenema Govt Hosp, Lassa Diagnost Lab, Minist Hlth & Sanitat, Kenema, Sierra Leone.
[Fair, Joseph N.] MRI Global, 1330 Piccard Ave, Rockville, MD USA.
RP Schoepp, RJ (reprint author), US Army, Med Res Inst Infect Dis, Diagnost Syst Div, 1425 Porter St, Ft Detrick, MD 21702 USA.
EM randal.j.schoepp.civ@mail.mil
FU Division of Global Emerging Infections Surveillance and Response System
(GEIS) Operations at the Armed Forces Health Surveillance Center,
through US Army Medical Research Institute of Infectious Diseases
(USAMRIID); Defense Threat Reduction Agency Cooperative Biological
Engagement Program, through Metabiota; National Research Council
Research Associateship Award at US Army Medical Research Institute of
Infectious Diseases (USAMRIID); Defense Threat Reduction Agency
Cooperative Biological Engagement Program
FX The study was funded in part by the Division of Global Emerging
Infections Surveillance and Response System (GEIS) Operations at the
Armed Forces Health Surveillance Center, through US Army Medical
Research Institute of Infectious Diseases (USAMRIID) and by the Defense
Threat Reduction Agency Cooperative Biological Engagement Program,
through Metabiota. Dr. O'Hearn was funded by the Defense Threat
Reduction Agency Cooperative Biological Engagement Program and National
Research Council Research Associateship Award at US Army Medical
Research Institute of Infectious Diseases (USAMRIID). Opinions,
interpretations, conclusions, and recommendations are those of the
authors and are not necessarily endorsed by the U.S. Army.
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PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1743-422X
J9 VIROL J
JI Virol. J.
PD OCT 3
PY 2016
VL 13
AR 163
DI 10.1186/s12985-016-0621-4
PG 6
WC Virology
SC Virology
GA DX9RU
UT WOS:000384733600001
PM 27716429
ER
PT J
AU Lan, M
Berenberg, J
Cheng, FKF
AF Lan, Mary
Berenberg, Jeffrey
Cheng, Fong-Kuei F.
TI A Unique and Aggressive Case of Helicobacter pylori-Positive Gastritis
with Diff use Large B Cell Lymphoma
SO AMERICAN JOURNAL OF GASTROENTEROLOGY
LA English
DT Meeting Abstract
CT 81st Annual Scientific Meeting of the
American-College-of-Gastroenterology
CY OCT 21-26, 2016
CL Las Vegas, NV
SP Amer Coll Gastroenterol
C1 [Lan, Mary; Cheng, Fong-Kuei F.] Tripler Army Med Ctr, Honolulu, HI 96859 USA.
[Berenberg, Jeffrey] Univ Hawaii, Ctr Canc, Tripler Army Med Ctr, Honolulu, HI 96822 USA.
NR 0
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PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0002-9270
EI 1572-0241
J9 AM J GASTROENTEROL
JI Am. J. Gastroenterol.
PD OCT
PY 2016
VL 111
SU 1
MA 2299
BP S1115
EP S1116
PG 2
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA EN1IV
UT WOS:000395764604061
ER
PT J
AU Lee, J
Carmichael, M
Cheng, F
AF Lee, John
Carmichael, Mark
Cheng, Fong
TI Recurrent Metastatic Melanoma Presenting as a Bleeding Gastric Polyp
SO AMERICAN JOURNAL OF GASTROENTEROLOGY
LA English
DT Meeting Abstract
CT 81st Annual Scientific Meeting of the
American-College-of-Gastroenterology
CY OCT 21-26, 2016
CL Las Vegas, NV
SP Amer Coll Gastroenterol
C1 [Lee, John; Carmichael, Mark; Cheng, Fong] Tripler Army Med Ctr, Honolulu, HI 96859 USA.
NR 0
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PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0002-9270
EI 1572-0241
J9 AM J GASTROENTEROL
JI Am. J. Gastroenterol.
PD OCT
PY 2016
VL 111
SU 1
MA 2315
BP S1125
EP S1125
PG 1
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA EN1IV
UT WOS:000395764604077
ER
PT J
AU Marowske, J
Shipley, B
Walton, D
Cochet, A
Schwake, J
AF Marowske, Johanna
Shipley, Brian
Walton, Douglas
Cochet, Allyson
Schwake, Jonathon
TI Peritoneal Mesothelioma: A Rare Cause of Abdominal Ascites
SO AMERICAN JOURNAL OF GASTROENTEROLOGY
LA English
DT Meeting Abstract
CT 81st Annual Scientific Meeting of the
American-College-of-Gastroenterology
CY OCT 21-26, 2016
CL Las Vegas, NV
SP Amer Coll Gastroenterol
C1 [Marowske, Johanna; Walton, Douglas; Schwake, Jonathon] Brooke Army Med Ctr, Jbsa Ft Sam Houston, TX USA.
[Shipley, Brian; Cochet, Allyson] San Antonio Mil Med Ctr, Ft Sam Houston, TX USA.
NR 0
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U1 0
U2 0
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0002-9270
EI 1572-0241
J9 AM J GASTROENTEROL
JI Am. J. Gastroenterol.
PD OCT
PY 2016
VL 111
SU 1
MA 2329
BP S1133
EP S1133
PG 1
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA EN1IV
UT WOS:000395764604091
ER
PT J
AU Szu, E
Cheng, FKF
AF Szu, Eric
Cheng, Fong-Kuei F.
TI Silent Myeloproliferative Neoplasm Presenting with a Late Variceal Bleed
SO AMERICAN JOURNAL OF GASTROENTEROLOGY
LA English
DT Meeting Abstract
CT 81st Annual Scientific Meeting of the
American-College-of-Gastroenterology
CY OCT 21-26, 2016
CL Las Vegas, NV
SP Amer Coll Gastroenterol
C1 [Szu, Eric; Cheng, Fong-Kuei F.] Tripler Army Med Ctr, Honolulu, HI 96859 USA.
NR 0
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U2 0
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0002-9270
EI 1572-0241
J9 AM J GASTROENTEROL
JI Am. J. Gastroenterol.
PD OCT
PY 2016
VL 111
SU 1
MA 1832
BP S879
EP S879
PG 1
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA EN1IV
UT WOS:000395764603132
ER
PT J
AU Shackelford, S
Pasley, J
Pugh, K
Granite, G
Chen, HG
Puche, A
Tisherman, S
Bowyer, M
Mackenzie, CF
AF Shackelford, Stacy
Pasley, Jason
Pugh, Kristy
Granite, Guinevere
Chen, Hegang
Puche, Adam
Tisherman, Samuel
Bowyer, Mark
Mackenzie, Colin F.
TI Critical Errors in Infrequently Performed Trauma Procedures up to 5
Years after Training among 85 Surgeons
SO JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
LA English
DT Meeting Abstract
CT Clinical Congress and Scientific Forum of the
American-College-of-Surgeons
CY OCT 15-20, 2016
CL Washington, DC
SP Amer Coll Surg
C1 US Army Inst Surg Res, San Antonio, TX USA.
Air Force Ctr Sustainment Trauma & Readiness Skil, Baltimore, MD USA.
Univ Maryland, Sch Med, Baltimore, MD 21201 USA.
Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
NR 0
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PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1072-7515
EI 1879-1190
J9 J AM COLL SURGEONS
JI J. Am. Coll. Surg.
PD OCT
PY 2016
VL 223
IS 4
SU 2
BP E218
EP E218
PG 1
WC Surgery
SC Surgery
GA EN2FL
UT WOS:000395825100483
ER
PT J
AU Dedekam, E
Walker, EA
AF Dedekam, Erik
Walker, Eric A.
TI Flag Football Finger Pop
SO MILITARY MEDICINE
LA English
DT Editorial Material
ID ENCHONDROMAS; HAND
C1 [Dedekam, Erik] Keller Army Community Hosp, 900 Washington Rd, West Point, NY 10996 USA.
[Walker, Eric A.] Penn State Coll Med, 500 Univ Dr, Hershey, PA 17033 USA.
RP Dedekam, E (reprint author), Keller Army Community Hosp, 900 Washington Rd, West Point, NY 10996 USA.
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PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD OCT
PY 2016
VL 181
IS 10
BP 1172
EP 1173
DI 10.7205/MILMED-D-16-00082
PG 2
WC Medicine, General & Internal
SC General & Internal Medicine
GA EL3DB
UT WOS:000394498700007
PM 27753546
ER
PT J
AU Malish, RG
AF Malish, Richard G.
TI Capitation as an Incentive for Transitioning to Patient-Centered Medical
Homes in the United States Army: A Brief Report
SO MILITARY MEDICINE
LA English
DT Article
ID PRIMARY-CARE; IMPLEMENTATION
AB The Army transitioned to a Patient-Centered Medical Home concept for primary care beginning in 2011. In spite of organizational commitment to the paradigm, the transition has not been without pitfalls. This performance improvement project operated under the hypothesis that focusing on the market-based incentives of a capitated system would result in a quantum leap toward the Patient-Centered Medical Home ideal. Utilizing a simple teaching device to repetitively highlight clinic and provider behaviors incentivized in a value-based payment system, a single clinic achieved significant improvements in enrollment, patient satisfaction, and measures associated with prevention while assuming an identity as a "virtual clinic". We recommend that the military consider a similar philosophy in educating clinics across the enterprise.
C1 [Malish, Richard G.] US Army Aeromed Res Lab, Command Suite, 6901 Farrel Rd, Dale County, AL 36362 USA.
RP Malish, RG (reprint author), US Army Aeromed Res Lab, Command Suite, 6901 Farrel Rd, Dale County, AL 36362 USA.
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PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD OCT
PY 2016
VL 181
IS 10
BP 1228
EP 1234
DI 10.7205/MILMED-D-15-00541
PG 7
WC Medicine, General & Internal
SC General & Internal Medicine
GA EL3DB
UT WOS:000394498700018
PM 27753557
ER
PT J
AU Lystrup, CRM
West, GF
Olsen, C
Ward, M
Stephens, MB
AF Lystrup, Capt Robert M.
West, Gordon F.
Olsen, Cara
Ward, Matthew
Stephens, Mark B.
TI Pedometry to Prevent Cardiorespiratory Fitness Decline-Is it Effective?
SO MILITARY MEDICINE
LA English
DT Article
ID PHYSICAL-ACTIVITY; HEALTH-BENEFITS; ACCELEROMETRY
AB Introduction: Physically active providers are more likely to prescribe exercise. Unfortunately, many become sedentary during their training. We examined pedometry as an incentive to promote physical activity in a cohort of medical students. Methods: This was a prospective, unblinded clinical trial of pedometry. 107 preclinical medical students volunteered. 50 students received Fitbit pedometers and 57 served as controls. All students ran 1.5- or 2-mile timed runs before pedometer issue, and again 1 year after. Change in run times were the primary outcome measure. Step counts, body composition, and exercise frequency were secondary outcomes. Results: 76% of students with pedometers reported increased motivation to exercise and 57% reported changing daily routines as a result of pedometry. Active pedometry participants declined from 48/50 initially to 22/50 over 13 months. Run times slowed an average of 5.0 seconds for pedometry users vs. 12.3 seconds for the control group. This difference was not statistically significant (p = 0.48). Conclusions: A subset of future physicians reported increased motivation to exercise after a trial of pedometry. However, adherence over the long term was poor and it seems to have a limited impact on aerobic exercise performance in this population.
C1 [Lystrup, Capt Robert M.] Nellis Air Force Base Family Med Residency, 4700 North Las Vegas Blvd, Las Vegas, NV 89191 USA.
[West, Gordon F.] Tripler Army Med Ctr, Ctr Nursing Res & Clin Inquiry, 1 Jarrett White Rd, Honolulu, HI 96859 USA.
[Olsen, Cara] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.
[Ward, Matthew] Uniformed Serv Univ Hlth Sci, Sch Med, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.
[Stephens, Mark B.] Uniformed Serv Univ Hlth Sci, Dept Family Med, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.
RP Lystrup, CRM (reprint author), Nellis Air Force Base Family Med Residency, 4700 North Las Vegas Blvd, Las Vegas, NV 89191 USA.
FU Alpha Omega Alpha Carolyn L. Kuckein Student Research Fellowship
FX We appreciate the $3,000 grant provided by the Alpha Omega Alpha Carolyn
L. Kuckein Student Research Fellowship.
NR 16
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PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD OCT
PY 2016
VL 181
IS 10
BP 1235
EP 1239
DI 10.7205/MILMED-D-15-00540
PG 5
WC Medicine, General & Internal
SC General & Internal Medicine
GA EL3DB
UT WOS:000394498700019
ER
PT J
AU Applewhite, L
Arincorayan, D
Adams, B
AF Applewhite, Larry
Arincorayan, Derrick
Adams, Barry
TI Exploring the Prevalence of Adverse Childhood Experiences in Soldiers
Seeking Behavioral Health Care During a Combat Deployment
SO MILITARY MEDICINE
LA English
DT Article
ID POSTTRAUMATIC-STRESS-DISORDER; MILITARY PERSONNEL; US ARMY; HOUSEHOLD
DYSFUNCTION; SUICIDAL-BEHAVIOR; PHYSICAL ABUSE; SEXUAL-ABUSE;
ACTIVE-DUTY; IRAQ; POSTDEPLOYMENT
AB This exploratory study examines the prevalence of adverse childhood experiences (ACEs) in soldiers who sought behavioral health support during a combat deployment. We conducted a secondary analysis of data extracted from two studies on the basis of retrospective reviews of behavioral health records of soldiers deployed to Iraq or Afghanistan. Of 162 clinical samples, 135 (83%) reported at least one type of childhood adversity. ACE scores ranged from 0 to 9 with a mean of 3 (standard deviation = 2.4) and mode of 0. A total of 65 (40%) experienced four or more ACEs. Parental divorce or separation was the most frequently reported childhood experience and was associated with witnessing domestic violence, having a member of the household abuse substances, and being physically and psychologically abused as a child. A sizeable proportion lived with a household member who had been in prison. Soldiers with an extensive history of ACEs may benefit from additional mentoring from frontline leaders and prevention measures instituted by unit behavioral health personnel.
C1 [Applewhite, Larry; Adams, Barry] US Army Med Dept Ctr & Sch, Hlth Readiness Ctr Excellence, 3630 Stanley Rd,Suite 011-2, Ft Sam Houston, TX 78234 USA.
[Arincorayan, Derrick] US Army Hlth Clin, Dept Behav Hlth, Bldg 673,Glennan Rd, Honolulu, HI 96857 USA.
RP Applewhite, L (reprint author), US Army Med Dept Ctr & Sch, Hlth Readiness Ctr Excellence, 3630 Stanley Rd,Suite 011-2, Ft Sam Houston, TX 78234 USA.
NR 52
TC 0
Z9 0
U1 0
U2 0
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD OCT
PY 2016
VL 181
IS 10
BP 1275
EP 1280
DI 10.7205/MILMED-D-15-00460
PG 6
WC Medicine, General & Internal
SC General & Internal Medicine
GA EL3DB
UT WOS:000394498700024
PM 27753563
ER
PT J
AU Ganem, VJ
Mora, AG
Nnamani, N
Bebarta, VS
AF Ganem, Victoria J.
Mora, Alejandra G.
Nnamani, Nina
Bebarta, Vikhyat S.
TI A 3-Year Comparison of Overdoses Treated in a Military Emergency
Department-Complications, Admission Rates, and Health Care Resources
Consumed
SO MILITARY MEDICINE
LA English
DT Article
ID PRESCRIPTION MONITORING PROGRAMS; OPERATION ENDURING FREEDOM;
UNITED-STATES; MEDICINE RESEARCH; NONMEDICAL USE; WAR VETERANS;
DRUG-USE; ABUSE; TRENDS; DEPLOYMENT
AB Background: Drug overdose has become a leading cause of death in the United States and is a growing issue in civilian and military populations. Increasing prescription drug misuse and poisonings translate into greater utilization of medical resources. Our objective was to describe the incidences of overdoses and their associated events and outcomes following emergency department consult. Methods: We performed a retrospective cohort study on cases evaluated in 2 military hospital emergency departments over 3 years. Subjects were identified using International Classification of Diseases, 9th Revision codes 960-970. Variables collected included demographics, military service, method of arrival, vital signs, clinical complications, and hospital admission, if overdose was documented as intentional or unintentional and drug ingested. Results: Over 3 years, 342 overdoses were treated. Mean age was 35 +/- 19 and gender was 53% female. 47% were active duty and 32% were dependents. 21% of overdoses involved benzodiazepines and 20% opioids. Active duty and benzodiazepine overdoses were more likely to arrive by ambulance (p = 0.0006, p = 0.03), were more likely to have overdosed intentionally (p = 0.02, p = 0.009), and were more likely to be admitted (p = 0.04, p = 0.007). Active duty had a longer length of stay (p = 0.02). Conclusion: Overdoses involving the active duty population and benzodiazepines consume greater military health care resources than other overdoses.
C1 [Ganem, Victoria J.; Mora, Alejandra G.] Air Force Route Care Res Ctr, Med Wing Chief Scientists Off 59, San Antonio Mil Med Ctr, 3698 Chambers Pass,Bldg 3611, Ft Sam Houston, TX 78234 USA.
[Nnamani, Nina] US Army Inst Surg Res, 3698 Chambers Pass,Bldg 3611, Ft Sam Houston, TX 78234 USA.
[Bebarta, Vikhyat S.] Univ Colorado, Sch Med, Dept Emergency Med, 12631 East 17th Ave Ste,C319, Aurora, CO 80045 USA.
RP Ganem, VJ (reprint author), Air Force Route Care Res Ctr, Med Wing Chief Scientists Off 59, San Antonio Mil Med Ctr, 3698 Chambers Pass,Bldg 3611, Ft Sam Houston, TX 78234 USA.
RI bebarta, vikhyat/K-3476-2015
NR 31
TC 0
Z9 0
U1 1
U2 1
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD OCT
PY 2016
VL 181
IS 10
BP 1281
EP 1286
DI 10.7205/MILMED-D-15-00508
PG 6
WC Medicine, General & Internal
SC General & Internal Medicine
GA EL3DB
UT WOS:000394498700025
PM 27753564
ER
PT J
AU Teyhen, DS
Shaffer, SW
Butler, RJ
Goffar, SL
Kiesel, KB
Rhon, DI
Boyles, RE
McMillian, DJ
Williamson, JN
Plisky, PJ
AF Teyhen, Deydre S.
Shaffer, Scott W.
Butler, Robert J.
Goffar, Stephen L.
Kiesel, Kyle B.
Rhon, Daniel I.
Boyles, Robert E.
McMillian, Daniel J.
Williamson, Jared N.
Plisky, Phillip J.
TI Application of Athletic Movement Tests that Predict Injury Risk in a
Military Population: Development of Normative Data
SO MILITARY MEDICINE
LA English
DT Article
ID Y-BALANCE TEST; LOWER-EXTREMITY INJURY; FUNCTIONAL MOVEMENT; INTERRATER
RELIABILITY; FOOTBALL PLAYERS; SCREEN; ASSOCIATION
AB Performance on movement tests helps to predict injury risk in a variety of physically active populations. Understanding baseline measures for normal is an important first step. Objectives: Determine differences in physical performance assessments and describe normative values for these tests based on military unit type. Methods: Assessment of power, balance, mobility, motor control, and performance on the Army Physical Fitness Test were assessed in a cohort of 1,466 soldiers. Analysis of variance was performed to compare the results based on military unit type (Rangers, Combat, Combat Service, and Combat Service Support) and analysis of covariance was performed to determine the influence of age and gender. Results: Rangers performed the best on all performance and fitness measures (p < 0.05). Combat soldiers performed better than Combat Service and Service Support soldiers on several physical performance tests and the Army Physical Fitness Test (p < 0.05). Performance in Combat Service and Service Support soldiers was equivalent on most measures (p < 0.05). Conclusions: Functional performance and level of fitness varied significantly by military unit type. Understanding these differences will provide a foundation for future injury prediction and prevention strategies.
C1 [Teyhen, Deydre S.; Shaffer, Scott W.] Baylor Univ, US Army, Doctoral Program Phys Therapy, ATTN MCCS HMT, 3151 Scott Rd,Suite 1301, Ft Sam Houston, TX 78234 USA.
[Teyhen, Deydre S.] US Army Med Command, 7700 Arlington Blvd, Falls Church, VA 22042 USA.
[Butler, Robert J.] Duke Univ, Med Ctr, Doctor Phys Therapy Program, Durham, NC 27708 USA.
[Goffar, Stephen L.] Univ Incarnate Word, Sch Phys Therapy, 4301 Broadway,CPO 412, San Antonio, TX 78250 USA.
[Kiesel, Kyle B.; Plisky, Phillip J.] Univ Evansville, Dept Phys Therapy, 1800 Lincoln Ave, Evansville, IN 47722 USA.
[Rhon, Daniel I.] Brooke Army Med Ctr, Ctr Intrepid, 3551 Roger Brooke Dr, Jbsa, TX 78234 USA.
[Boyles, Robert E.; McMillian, Daniel J.] Univ Puget Sound, Sch Phys Therapy, 1500 N Warner St, Tacoma, WA 98416 USA.
[Williamson, Jared N.] Tacoma Strength Unbroken, 2354 Jefferson Ave, Tacoma, WA 98402 USA.
RP Teyhen, DS (reprint author), Baylor Univ, US Army, Doctoral Program Phys Therapy, ATTN MCCS HMT, 3151 Scott Rd,Suite 1301, Ft Sam Houston, TX 78234 USA.; Teyhen, DS (reprint author), US Army Med Command, 7700 Arlington Blvd, Falls Church, VA 22042 USA.
FU U.S. Army Medical Research and Materiel Command (MRMC); U.S. Army
Medical Department Advanced Medical Technology Initiative (AAMTI);
Telemedicine and Advanced Technology Research Center (TATRC); Military
Operational Medicine Research Program (MOM); Defense Medical Research
and Development Program; Joint Base Lewis McChord's Physical Therapy
Clinic, Madigan Army Medical Center, Tacoma WA; 2/75th Ranger Regiment,
Joing Base Lewis McChord, WA
FX This research trial was supported by the U.S. Army Medical Research and
Materiel Command (MRMC), U.S. Army Medical Department Advanced Medical
Technology Initiative (AAMTI), Telemedicine and Advanced Technology
Research Center (TATRC), the Military Operational Medicine Research
Program (MOM), and the Defense Medical Research and Development Program.
Additional research support was provided by Joint Base Lewis McChord's
Physical Therapy Clinic, Madigan Army Medical Center, Tacoma WA; and the
2/75th Ranger Regiment, Joing Base Lewis McChord, WA.
NR 42
TC 0
Z9 0
U1 1
U2 1
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD OCT
PY 2016
VL 181
IS 10
BP 1324
EP 1334
DI 10.7205/MILMED-D-15-00297
PG 11
WC Medicine, General & Internal
SC General & Internal Medicine
GA EL3DB
UT WOS:000394498700032
PM 27753571
ER
PT J
AU Bardenheier, BH
Duffy, J
Duderstadt, SK
Higgs, JB
Keith, MP
Papadopoulos, PJ
Gilliland, WR
McNeil, MM
AF Bardenheier, Barbara H.
Duffy, Jonathan
Duderstadt, Susan K.
Higgs, Jay B.
Keith, Michael P.
Papadopoulos, Patricia J.
Gilliland, William R.
McNeil, Michael M.
TI Anthrax Vaccine and the Risk of Rheumatoid Arthritis and Systemic Lupus
Erythematosus in the US Military: A Case-Control Study
SO MILITARY MEDICINE
LA English
DT Article
ID REVISED CRITERIA; CHRONIC ARTHROPATHY; AMERICAN-COLLEGE;
RANDOMIZED-TRIAL; ARMED-FORCES; CLASSIFICATION; IMMUNIZATION;
VACCINATIONS; MINNESOTA; MORTALITY
AB U.S. military personnel assigned to areas deemed to be at high risk for anthrax attack receive Anthrax Vaccine Adsorbed (AVA). Few cases of rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) have been reported in persons who received AVA. Using a matched case-control study design, we assessed the relationship of RA and SLE with AVA vaccination using the Defense Medical Surveillance System. We identified potential cases using International Classification of Diseases, 9th Revision, Clinical Modification codes and confirmed cases with medical record review and rheumatologist adjudication. Using conditional logistic regression, we estimated odds ratios (OR) for AVA exposure during time intervals ranging from 90 to 1,095 days before disease onset. Among 77 RA cases, 13 (17%) had ever received AVA. RA cases were no more likely than controls to have received AVA when looking back 1,095 days (OR: 1.03; 95% confidence interval [CI]: 0.48-2.19) but had greater odds of exposure in the prior 90 days (OR: 3.93; 95% CI: 1.08-14.27). Among the 39 SLE cases, 5 (13%) had ever received AVA; no significant difference in receipt of AVA was found when compared with controls (OR: 0.91; 95% CI: 0.26-3.25). AVA was associated with recent onset RA, but did not increase the risk of developing RA in the long term.
C1 [Bardenheier, Barbara H.; Duffy, Jonathan; Duderstadt, Susan K.; McNeil, Michael M.] Ctr Dis Control & Prevent, Immunizat Safety Off, MS D-26,1600 Clifton Rd NE, Atlanta, GA 30333 USA.
[Higgs, Jay B.] Brooke Army Med Ctr, Rheumatol Serv, 3851 Roger Brooke Dr, San Antonio, TX 78234 USA.
[Keith, Michael P.] Walter Reed Natl Mil Med Ctr, Rheumatol Serv, 4954 N Palmer Rd, Bethesda, MD 20889 USA.
[Papadopoulos, Patricia J.] MultiCare Rheumatol Specialists, 1901 S Union Ave,Suite A221, Tacoma, WA 98405 USA.
[Gilliland, William R.] Uniformed Serv Univ Hlth Sci, Dept Med, 4301 Jones Bridge Rd,Room A 1005, Bethesda, MD 20814 USA.
RP Bardenheier, BH (reprint author), Ctr Dis Control & Prevent, Immunizat Safety Off, MS D-26,1600 Clifton Rd NE, Atlanta, GA 30333 USA.
FU CDC
FX The authors gratefully acknowledge Tim Struttmann, MSPH, PMP, and Joan
Jacobs, RN, of SRA International, Inc., for technical assistance;
Angelia A. Eick-Cost, PhD, ScM, Armed Forces Health Surveillance Center,
Silver Spring, MD, for assistance providing study data. The authors also
thank Frank DeStefano, MD, MPH, for his critical review of the
manuscript. The funding for this study was provided solely by the CDC.
NR 29
TC 0
Z9 0
U1 0
U2 0
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD OCT
PY 2016
VL 181
IS 10
BP 1348
EP 1356
DI 10.7205/MILMED-D-15-00485
PG 9
WC Medicine, General & Internal
SC General & Internal Medicine
GA EL3DB
UT WOS:000394498700035
PM 27753574
ER
PT J
AU Story, KL
Bukhari, AS
Bovill, M
AF Story, Kerryn L.
Bukhari, Asma S.
Bovill, Maria
TI Roles of the Military Dietitian in Combat Operations and Humanitarian
Assistance-Professional Development and Utilization
SO MILITARY MEDICINE
LA English
DT Article
ID ARMY DIETITIANS
AB Military dietitians have long been valued members of the health care team, called on for their expertise as early as World War I. However, in the more recent conflicts over the past two decades, their role in health care delivery as a component of medical stability operations has been largely undefined. The purpose of this study was to explore the types of missions supported by U.S. military dietitians and characterize any unique competencies critical to their success during these missions using an online questionnaire. Sixty-five military dietitians responded to an online questionnaire and 49 (75%) shared their deployment experiences, lessons learned, and recommendations for future training based on 57 deployments from 1975 to 2014. Results indicated that during these deployments nutrition- and dietetics-related competencies were capitalized along with staff positions in support of combat and humanitarian operations. The majority (n = 24; 51%) valued mentorship as a useful resource before deployments followed by field experience (45%) and Web-based training (43%). The authors propose standardized formal training for military dietitians aimed at increasing strategic level awareness of partnerships and collaborations between U.S. Government and interagency organizations; these associations are vital for sustained synchronization of global health efforts.
C1 [Story, Kerryn L.] Baylor Univ, US Mil, AMEDD Ctr & Sch, Grad Program Nutr, 2250 Stanley Rd, San Antonio, TX 78234 USA.
[Bukhari, Asma S.] US Army Res Inst Environm Med, Mil Nutr Div, 15 Kansas St, Natick, MA 01760 USA.
[Bovill, Maria] Border Consortium, 12-5 Convent Rd, Bangkok 10500, Thailand.
RP Story, KL (reprint author), Baylor Univ, US Mil, AMEDD Ctr & Sch, Grad Program Nutr, 2250 Stanley Rd, San Antonio, TX 78234 USA.
NR 14
TC 0
Z9 0
U1 0
U2 0
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD OCT
PY 2016
VL 181
IS 10
BP 1363
EP 1369
DI 10.7205/MILMED-D-15-00509
PG 7
WC Medicine, General & Internal
SC General & Internal Medicine
GA EL3DB
UT WOS:000394498700037
PM 27753576
ER
PT J
AU Heitmann, RJ
Batig, AL
Levy, G
Novotney, J
Grubbs, C
Batig, TS
Gobern, JM
Hemman, E
Christy, AY
Hill, MJ
AF Heitmann, Ryan J.
Batig, Alison L.
Levy, Gary
Novotney, Jonathan
Grubbs, Calvin, III
Batig, Timothy S.
Gobern, Joseph M.
Hemman, Eileen
Christy, Alicia Y.
Hill, Micah J.
TI Unintended Pregnancy in the Military Health Care System: Who Is Really
at Risk?
SO MILITARY MEDICINE
LA English
DT Article
ID ACTIVE-DUTY SERVICEWOMEN; UNITED-STATES; UNPLANNED PREGNANCY;
CONTRACEPTION; WOMEN; US; COHORT
AB Unintended pregnancy is a global issue and one that is reportedly to be higher in the military population. We sought to assess rates of unintended pregnancy among the active duty population in comparison to other military health care beneficiaries. Using a validated six-question survey, patients aged 18 to 42 were surveyed in five different clinics at three major tertiary hospitals from December 2013 to December 2014. Individual survey questions were scored 0, 1, or 2 and a total score was tabulated. A total score of 0 to 3 indicated unintended pregnancy, 4 to 9 indicated ambivalence toward pregnancy, and 10 to 12 indicated intended pregnancy. Subanalysis was performed on two survey questions specifically looking at pregnancy intentions. A total of 1,211 completed surveys were analyzed. Overall, 6.9% of all respondents had an unintended pregnancy compared to 23% of pregnancies in single active duty women. Single, active duty service members were more likely to indicate they did not intend to get pregnant or want a baby before becoming pregnant. Overall, the rate of unintended pregnancy among military health care beneficiaries is low. However, single active duty women are at significantly higher risk for unintended pregnancy and specifically targeted interventions should be implemented for this population.
C1 [Heitmann, Ryan J.; Batig, Alison L.; Hemman, Eileen] Madigan Army Med Ctr, Dept Obstet & Gynecol, 9040 Jackson Ave, Tacoma, WA 98431 USA.
[Heitmann, Ryan J.; Gobern, Joseph M.; Hill, Micah J.] Walter Reed Natl Mil Med Ctr, Dept Obstet & Gynecol, 8901 Wisconsin Ave, Bethesda, MD 20889 USA.
[Levy, Gary] Tripler Army Med Ctr, Dept Obstet & Gynecol, 1 Jarrett White Rd, Honolulu, HI 96859 USA.
[Novotney, Jonathan; Grubbs, Calvin, III] Madigan Army Med Ctr, Dept Family Med, 9040 Jackson Ave, Tacoma, WA 98431 USA.
[Batig, Timothy S.] Soldier Ctr Med Home, Joint Base Lewis McChord, 17th FAB 555 EN BDE, Tacoma, WA 98431 USA.
[Christy, Alicia Y.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Contracept Discovery Branch, NIH, 31 Ctr Dr, Bethesda, MD 20892 USA.
RP Heitmann, RJ (reprint author), Madigan Army Med Ctr, Dept Obstet & Gynecol, 9040 Jackson Ave, Tacoma, WA 98431 USA.; Heitmann, RJ (reprint author), Walter Reed Natl Mil Med Ctr, Dept Obstet & Gynecol, 8901 Wisconsin Ave, Bethesda, MD 20889 USA.
NR 18
TC 0
Z9 0
U1 0
U2 0
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD OCT
PY 2016
VL 181
IS 10
BP 1370
EP 1374
DI 10.7205/MILMED-D-16-00003
PG 5
WC Medicine, General & Internal
SC General & Internal Medicine
GA EL3DB
UT WOS:000394498700038
PM 27753577
ER
PT J
AU Donelan, K
Romano, C
Buerhaus, P
DesRoches, C
Applebaum, S
Ward, JRM
Schoneboom, BA
Hinshaw, AS
AF Donelan, Karen
Romano, Carol
Buerhaus, Peter
DesRoches, Catherine
Applebaum, Sandra
Ward, Johanna R. M.
Schoneboom, Bruce A.
Hinshaw, Ada Sue
TI National Surveys of Military Personnel, Nursing Students, and the
Public: Drivers of Military Nursing Careers (vol 179, pg 565, 2014)
SO MILITARY MEDICINE
LA English
DT Correction
C1 [Donelan, Karen] Massachusetts Gen Hosp, Mongan Inst Hlth Policy, 50 Staniford St,9th Floor, Boston, MA 02114 USA.
[Romano, Carol; Hinshaw, Ada Sue] Uniformed Serv Univ Hlth Sci, Grad Sch Nursing, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.
[Buerhaus, Peter] Vanderbilt Univ, Med Ctr, Inst Med & Publ Hlth, Ctr Interdisciplinary Hlth Workforce Studies, 2525 West End Ave,Suite 600,Sixth Floor, Nashville, TN 37203 USA.
[DesRoches, Catherine] Math Policy Res, 955 Massachusetts Ave,Suite 900, Cambridge, MA 02139 USA.
[Applebaum, Sandra] Harris Interact Inc, 902 Broadway,6th Floor, New York, NY 10010 USA.
[Ward, Johanna R. M.] Math Policy Res, POB 2393, Princeton, NJ 08543 USA.
[Schoneboom, Bruce A.] US Army, Med Res Inst Chem Def, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA.
RP Donelan, K (reprint author), Massachusetts Gen Hosp, Mongan Inst Hlth Policy, 50 Staniford St,9th Floor, Boston, MA 02114 USA.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD OCT
PY 2016
VL 181
IS 10
BP 1391
EP 1391
DI 10.7205/MILMED-D-16-00295
PG 1
WC Medicine, General & Internal
SC General & Internal Medicine
GA EL3DB
UT WOS:000394498700045
PM 27753584
ER
PT J
AU Pajcin, M
Banks, S
White, JM
Dorrian, J
Paech, GM
Grant, C
Tooley, K
Kamimori, G
Della Vedova, C
AF Pajcin, M.
Banks, S.
White, J. M.
Dorrian, J.
Paech, G. M.
Grant, C.
Tooley, K.
Kamimori, G.
Della Vedova, C.
TI SALIVARY ALPHA-ANYLASE: A POTENTIAL BIOMARKER OF REACTION TIME DURING
TOTAL SLEEP DEPRIVATION
SO JOURNAL OF SLEEP RESEARCH
LA English
DT Meeting Abstract
C1 [Pajcin, M.; White, J. M.; Della Vedova, C.] Univ South Australia, Sch Pharm & Med Sci, Adelaide, SA, Australia.
[Banks, S.; Dorrian, J.; Paech, G. M.; Grant, C.] Univ South Australia, Ctr Sleep Res, Adelaide, SA, Australia.
[Tooley, K.] Def Sci & Technol Grp, Dept Def, Edinburgh, SA, Australia.
[Kamimori, G.] Walter Reed Army Inst Res, Behav Biol Branch, Silver Spring, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0962-1105
EI 1365-2869
J9 J SLEEP RES
JI J. Sleep Res.
PD OCT
PY 2016
VL 25
SU 2
SI SI
MA 037
BP 11
EP 12
PG 2
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA EJ2IG
UT WOS:000393032700020
ER
PT J
AU Beltran, MJ
Becker, TE
Hurley, RK
Gurney, JM
Hayda, RA
AF Beltran, Michael J.
Becker, Tyson E.
Hurley, Richard K.
Gurney, Jennifer M.
Hayda, Roman A.
TI Resuscitation and Treatment of Shock
SO JOURNAL OF ORTHOPAEDIC TRAUMA
LA English
DT Article
DE shock; hemorrhage; damage control; resuscitation
ID ENDOVASCULAR BALLOON OCCLUSION; DAMAGE-CONTROL RESUSCITATION;
FREEZE-DRIED PLASMA; OPERATION ENDURING FREEDOM; TEMPORARY VASCULAR
SHUNTS; COMBAT CASUALTY CARE; HEMORRHAGIC-SHOCK; TRANEXAMIC ACID; IRAQI
FREEDOM; TRAUMA
AB Hemorrhage continues to be the most common cause of death among service members wounded in combat. Injuries that were previously nonsurvivable in previous wars are now routinely seen by combat surgeons in forward surgical units, the result of improvements in body armor, the universal use of field tourniquets to control extremity hemorrhage at the point of injury, and rapid air evacuation strategies. Combat orthopaedic surgeons remain a vital aspect of the forward surgical unit, tasked with assisting general surgical colleagues in the resuscitation of patients in hemorrhagic shock while also addressing traumatic amputations, open and closed long bone fractures, and mechanically unstable pelvic trauma. Future military and civilian trauma research endeavors will seek to identify how the advances made in the past 15 years will translate toward the emerging battlefield of the future, one where forward surgical units must be lighter, smaller, and more mobile to address the changing scope of military combat operations.
C1 [Beltran, Michael J.; Hurley, Richard K.] San Antonio Mil Med Ctr, Dept Orthopaed Surg, 3551 Roger Brooke Dr, San Antonio, TX 78234 USA.
[Becker, Tyson E.] San Antonio Mil Med Ctr, Dept Surg Trauma & Crit Care, San Antonio, TX USA.
[Gurney, Jennifer M.] US Army Inst Surg Res, San Antonio, TX USA.
[Hayda, Roman A.] Brown Univ, Dept Orthopaed Surg, Providence, RI 02912 USA.
RP Beltran, MJ (reprint author), San Antonio Mil Med Ctr, Dept Orthopaed Surg, 3551 Roger Brooke Dr, San Antonio, TX 78234 USA.
EM mbeltran0514@gmail.com
NR 52
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0890-5339
EI 1531-2291
J9 J ORTHOP TRAUMA
JI J. Orthop. Trauma
PD OCT
PY 2016
VL 30
SU 3
BP S2
EP S6
DI 10.1097/BOT.0000000000000670
PG 5
WC Orthopedics; Sport Sciences
SC Orthopedics; Sport Sciences
GA EH4DX
UT WOS:000391722500002
ER
PT J
AU Erdle, NJ
Verwiebe, EG
Wenke, JC
Smith, CS
AF Erdle, Nicholas J.
Verwiebe, Eric G.
Wenke, Joseph C.
Smith, Christopher S.
TI Debridement and Irrigation: Evolution and Current Recommendations
SO JOURNAL OF ORTHOPAEDIC TRAUMA
LA English
DT Article
DE debridement; irrigation; war wounds; blast injuries; trauma
ID PRESSURE WOUND THERAPY; DAKINS SOLUTION; SOFT-TISSUE; MODEL;
COMPLICATIONS; FRACTURES; BACTERIA; DEVICES; SALINE
AB Debridement is an integral step in the orthopaedic management of traumatic wounds, from open soft tissue injuries and routine open fracture care to the management of extensive high-energy blast injuries. While the necessity of debridement has been well established, the level of energy and degree of contamination of blast wounds encountered in recent armed conflict has offered a challenge and a new opportunity for military surgeons to revisit the most recent literature to guide our practice with the best evidence currently available. While the core tenants of removing the nonviable tissue and preserving the viable to maintain the best functional outcome have not changed, new wound care therapies and advances in prosthetics and salvage techniques and the ability to rapidly evacuate casualties have changed the approach to care provided on the front lines. This paper seeks to review the core principles of debridement and guide treatment using evidence-based methods that can be applied to contaminated open injuries on the battlefront and disaster and intentional violence injuries abroad and at home.
C1 [Erdle, Nicholas J.; Smith, Christopher S.] Naval Med Ctr Portsmouth, Dept Orthopead, Portsmouth, VA USA.
[Verwiebe, Eric G.] Tripler Army Med Ctr, Dept Orthopead, Honolulu, HI 96859 USA.
[Wenke, Joseph C.] US Army Inst Surg Res, San Antonio, TX USA.
RP Smith, CS (reprint author), Naval Med Ctr Portsmouth, Dept Orthopaed Surg, US Navy, Med Corps, 620 John Paul Jones Circle, Portsmouth, VA 23708 USA.
EM christopher.s.smith92.mil@mail.mil
NR 21
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0890-5339
EI 1531-2291
J9 J ORTHOP TRAUMA
JI J. Orthop. Trauma
PD OCT
PY 2016
VL 30
SU 3
BP S7
EP S10
DI 10.1097/BOT.0000000000000671
PG 4
WC Orthopedics; Sport Sciences
SC Orthopedics; Sport Sciences
GA EH4DX
UT WOS:000391722500003
ER
PT J
AU Rivera, JC
Pasquina, PF
AF Rivera, Jessica C.
Pasquina, Paul F.
TI Comprehensive Rehabilitation Following Combat Extremity Trauma:
Evolution and Its Impact on Outcomes
SO JOURNAL OF ORTHOPAEDIC TRAUMA
LA English
DT Article
DE combat injury; trauma rehabilitation; comprehensive rehabilitation;
multidisciplinary; functional outcomes
ID TARGETED MUSCLE REINNERVATION; WOUNDED WARRIOR; LIMB SALVAGE;
DISABILITY; AMPUTATION; RETURN; DUTY; SERVICEMEMBERS; PARTICIPATION;
INTERVENTIONS
AB Recent military combat operations have resulted in a high burden of extremity-related long-term disability due to limb amputation and persistent deficits despite limb reconstruction. The US Army amputee care programs, established at focused centers with interdisciplinary care teams, have redefined the standard of how rehabilitation following limb loss is undertaken as the limb reconstruction is just one part of the entire patient's restoration of wellness and reintegration. Inspired by this approached, comprehensive rehabilitation programs designed for patients with limb reconstruction have also excelled rehabilitation following a spectrum of severe limb trauma. These programs, which include advances in orthotics and orthosis training, have improved function and military retention among the limb salvage patient population. Lessons learned from comprehensive rehabilitation efforts emphasize the value of highly skilled, interprofessional care teams and the overall wellness of the patients. Although this approach is resource intensive and not available in all health care systems, civilian trauma counterparts can learn from the example of holistic attention to the patient's recovery.
C1 [Rivera, Jessica C.] US Army Inst Surg Res, Ft Sam Houston, TX USA.
[Rivera, Jessica C.] San Antonio Mil Med Ctr, Dept Orthopaed Surg, Ft Sam Houston, TX USA.
[Pasquina, Paul F.] Walter Reed Natl Mil Med Ctr, Bethesda, MD USA.
[Pasquina, Paul F.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
RP Rivera, JC (reprint author), JBSA Ft Sam Houston, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA.
EM Jessica.c.rivera14.mil@mail.mil
NR 37
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0890-5339
EI 1531-2291
J9 J ORTHOP TRAUMA
JI J. Orthop. Trauma
PD OCT
PY 2016
VL 30
SU 3
BP S31
EP S33
DI 10.1097/BOT.0000000000000672
PG 3
WC Orthopedics; Sport Sciences
SC Orthopedics; Sport Sciences
GA EH4DX
UT WOS:000391722500008
ER
PT J
AU Stinner, DJ
Fleming, ME
AF Stinner, Daniel J.
Fleming, Mark E.
TI Untitled
SO JOURNAL OF ORTHOPAEDIC TRAUMA
LA English
DT Editorial Material
C1 [Stinner, Daniel J.; Fleming, Mark E.] OTA, Mil Comm, San Antonio, TX USA.
[Stinner, Daniel J.] San Antonio Mil Med Ctr, Dept Orthoaped Surg, San Antonio, TX USA.
[Stinner, Daniel J.] US Army Inst Surg Res, Dept Extrem Trauma & Regenerat Med, San Antonio, TX USA.
[Fleming, Mark E.] Los Angeles Cty USC Med Ctr, Navy Trauma Training Ctr, Los Angeles, CA USA.
RP Stinner, DJ (reprint author), OTA, Mil Comm, San Antonio, TX USA.; Stinner, DJ (reprint author), San Antonio Mil Med Ctr, Dept Orthoaped Surg, San Antonio, TX USA.; Stinner, DJ (reprint author), US Army Inst Surg Res, Dept Extrem Trauma & Regenerat Med, San Antonio, TX USA.
NR 4
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0890-5339
EI 1531-2291
J9 J ORTHOP TRAUMA
JI J. Orthop. Trauma
PD OCT
PY 2016
VL 30
SU 3
BP S1
EP S1
DI 10.1097/BOT.0000000000000679
PG 1
WC Orthopedics; Sport Sciences
SC Orthopedics; Sport Sciences
GA EH4DX
UT WOS:000391722500001
ER
PT J
AU Yun, HC
Murray, CK
Nelson, KJ
Bosse, MJ
AF Yun, Heather C.
Murray, Clinton K.
Nelson, Kenneth J.
Bosse, Michael J.
TI Infection After Orthopaedic Trauma: Prevention and Treatment
SO JOURNAL OF ORTHOPAEDIC TRAUMA
LA English
DT Article
DE combat; military; trauma; osteomyelitis; infection; orthopaedic
ID OPEN TIBIA FRACTURES; INVASIVE FUNGAL-INFECTIONS; COMBAT-RELATED
INJURIES; GRAM-NEGATIVE BACTERIA; LOWER-EXTREMITY TRAUMA; US ARMY
SOLDIERS; WOUND INFECTIONS; ACINETOBACTER-BAUMANNII; CUTANEOUS
MUCORMYCOSIS; COLONIZATION
AB Trauma to the extremities is disproportionately represented in casualties of recent conflicts, accounting for >50% of injuries sustained during operations in Iraq and Afghanistan. Infectious complications have been reported in >25% of those evacuated for trauma, and 50% of such patients were treated in the intensive care unit (ICU). Osteomyelitis has been reported in 9% (14% of intensive care unit patients), and deep-wound infection in 27% of type III open-tibia fractures. Infections complicating extremity trauma are frequently caused by multidrug-resistant bacteria and have been demonstrated to lead to failure of limb salvage, unplanned operative take-backs, late amputations, and decreased likelihood of returning to duty. Invasive fungal infections of extremities have also presented a unique challenge in combat-injured patients, particularly in those with blast injuries with massive transfusion requirements and high injury severity scores. Infection prevention should begin at the time of injury and, although context-specific depending on the level of care, includes appropriate irrigation, surgical debridement, wound care and coverage, fracture fixation, and antibiotic prophylaxis, in addition to basic infection prevention measures. Clinical practice guidelines to address infection prevention after combat trauma (including extremity infection) were developed in 2007 and revised in 2011, with endorsement from the Surgical Infection Society and the Infectious Disease Society of America. Nevertheless, significant challenges remain, including austere environments of care, multiple transitions of care, and lack of coordinated efforts in prevention. Treatment of established infections is optimally multidisciplinary, particularly when deep wounds, bone, and joints are involved. Surgical debridement of overtly infected or necrotic tissue is necessary, with particularly aggressive margins if invasive fungal infection is suspected. Infected nonunion frequently requires the use of prosthetic materials for fixation, potentiating biofilm formation, and complicating medical therapy. Antibiotic therapy should be targeted at results of deep wound and bone cultures. However, this is complicated by frequent contamination of wounds, requiring differentiation between potential pathogens in terms of their virulence and decreased culture recovery in patient who have frequently received previous antibiotics. Lessons learned in infection prevention and treatment of orthopaedic trauma from combat can serve to inform the care of patients injured in natural disasters and noncombat trauma.
C1 [Yun, Heather C.; Murray, Clinton K.] JBSA Ft Sam Houston, San Antonio Mil Med Ctr, Dept Infect Dis Serv, Houston, TX USA.
[Yun, Heather C.; Murray, Clinton K.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
[Nelson, Kenneth J.] Womack Army Med Ctr, Dept Orthopaed & Rehabil, Ft Bragg, NC USA.
[Bosse, Michael J.] Carolinas Med Ctr, Dept Orthopaed, Charlotte, NC 28203 USA.
RP Yun, HC (reprint author), JBSA Ft Sam Houston, MCHE ZDM 1,3551 Roger Brooke Lane, Ft Sam Houston, TX 78234 USA.
EM Heather.c.yun.mil@mail.mil
NR 62
TC 0
Z9 0
U1 2
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0890-5339
EI 1531-2291
J9 J ORTHOP TRAUMA
JI J. Orthop. Trauma
PD OCT
PY 2016
VL 30
SU 3
BP S21
EP S26
DI 10.1097/BOT.0000000000000667
PG 6
WC Orthopedics; Sport Sciences
SC Orthopedics; Sport Sciences
GA EH4DX
UT WOS:000391722500006
ER
PT J
AU Veksler, VD
Buchler, N
Lebiere, C
Morrison, D
Kelley, T
AF Veksler, Vladislav D.
Buchler, Norbou
Lebiere, Christian
Morrison, Don
Kelley, Troy
TI The performance comparison problem: Universal task access for
cross-framework evaluation, Turing tests, grand challenges, and
cognitive decathlons
SO BIOLOGICALLY INSPIRED COGNITIVE ARCHITECTURES
LA English
DT Article
DE Grand challenge; Cognitive decathlon; Turing test; Performance
comparison; Simulation; API; Standards
AB A driver for achieving human-level AI and high-fidelity cognitive architectures is the ability to easily test and compare the performance and behavior of computational agents/models to humans and to one another. One major difficulty in setting up and getting participation in large-scale cognitive decathlon and grand challenge competitions, or even smaller scale cross-framework evaluation and Turing testing, is that there is no standard interface protocol that enables and facilitates human and computational agent "plug-and-play" participation across various tasks. We identify three major issues. First, human-readable task interfaces aren't often translated into machine-readable form. Second, in the cases where a task interface is made available in a machine-readable protocol, the protocol is often task-specific, and differs from other task protocols. Finally, where both human and machine-readable versions of the task interface exist, the two versions often differ in content. This makes the bar of entry extremely high for comparison of humans and multiple computational frameworks across multiple tasks. This paper proposes a standard approach to task design where all task interactions adhere to a standard API. We provide examples of how this method can be employed to gather human and computational simulation data in text-and button tasks, visual and animated tasks, and in real-time robotics tasks. (C) 2016 Elsevier B.V. All rights reserved.
C1 [Veksler, Vladislav D.] US Army Res Lab, DCS Corp, HRED, Aberdeen Proving Ground, MD 21005 USA.
[Buchler, Norbou; Kelley, Troy] US Army Res Lab, HRED, Aberdeen Proving Ground, MD USA.
[Lebiere, Christian; Morrison, Don] Carnegie Mellon Univ, Dept Psychol, Pittsburgh, PA 15213 USA.
RP Veksler, VD (reprint author), US Army Res Lab, DCS Corp, HRED, Aberdeen Proving Ground, MD 21005 USA.
EM vdv718@gmail.com
FU [W911NF-09-2-0053]
FX We would like to thank Cleotilde Gonzalez, Michael Yu, Marshall Scott
Poole, Alex Yahja, Tarek Abdelzaher, Eric Avery, and Sean McGhee for all
of their support and contributions that enabled this work. This work was
funded under Cooperative Agreement Number W911NF-09-2-0053.
NR 28
TC 0
Z9 0
U1 1
U2 1
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 2212-683X
EI 2212-6848
J9 BIOL INSPIR COGN ARC
JI Biol. Inspired Cogn. Archit.
PD OCT
PY 2016
VL 18
BP 9
EP 22
DI 10.1016/j.bica.2016.10.003
PG 14
WC Computer Science, Artificial Intelligence; Neurosciences
SC Computer Science; Neurosciences & Neurology
GA EF7ML
UT WOS:000390513600002
ER
PT J
AU Schroeder, SL
AF Schroeder, Sara L.
TI Addressing the Risk of Postpartum Depression in Female Veterans
SO INTERNATIONAL JOURNAL OF CHILDBIRTH EDUCATION
LA English
DT Article
DE postpartum; depression; female; veterans; education
AB Female Veterans are the fastest growing demographic within the Veterans Affairs. Today's female Veteran is likely younger, likely deployed multiple times and may have posttraumatic stress disorder (PTSD). Research indicates that women with PTSD are at a greater risk for experiencing postpartum depression. VA provides maternity services, but the caregivers are normally outside the VA health care system. For this reason, it is imperative that non-VA providers are aware of the increased risk of post-partum depression and tools that are available to screen and advocate for this unique population. Resources are available within the VA to assist these female heroes through a potentially difficult time.
C1 [Schroeder, Sara L.] Aleda E Lutz VAMC, Saginaw, MI 48602 USA.
[Schroeder, Sara L.] US Army, Washington, DC 20301 USA.
RP Schroeder, SL (reprint author), Aleda E Lutz VAMC, Saginaw, MI 48602 USA.; Schroeder, SL (reprint author), US Army, Washington, DC 20301 USA.
NR 11
TC 0
Z9 0
U1 0
U2 0
PU INT CHILDBIRTH EDUCATION ASSOC
PI RALEIGH
PA 1500 SUNDAY DR, STE 102, RALEIGH, NC 27607 USA
SN 0887-8625
J9 INT J CHILDBIRTH EDU
JI Int. J. Childbirth Educ.
PD OCT
PY 2016
VL 31
IS 4
BP 21
EP 23
PG 3
WC Nursing
SC Nursing
GA EF6GD
UT WOS:000390428200007
ER
PT J
AU Allen, JB
AF Allen, J. B.
TI Simulations of Anisotropic Texture Evolution on Paramagnetic and
Diamagnetic Materials Subject to a Magnetic Field Using Q-State Monte
Carlo
SO JOURNAL OF ENGINEERING MATERIALS AND TECHNOLOGY-TRANSACTIONS OF THE ASME
LA English
DT Article
ID GRAIN-GROWTH; COMPUTER-SIMULATION; MICROSTRUCTURE; ORIENTATION;
COATINGS; BISMUTH; MOTION; ALLOY
AB The present work incorporates a modified Q-state Monte Carlo (Potts) model to evaluate two-dimensional annealing of representative paramagnetic and diamagnetic polycrystalline materials in the presence of a magnetic field. Anisotropies in grain boundary energy, caused by differences in grain orientation (texturing), and the presence of an external magnetic field are examined in detail. In the former case, the Read-Shockley equations are used, in which grain boundary energies are computed using a low-angle misorientation approximation. In the latter case, magnetic anisotropy is simulated based on the relative orientation between the principal grain axis and the external magnetic field vector. Among other findings, the results of texture development subject to a magnetic field showed an increasing orientation distribution function (ODF) asymmetry over time, with higher intensities favoring the grains with principal axes most closely aligned with the magnetic field direction. The magnetic field also tended to increase the average grain size, which was accompanied by a corresponding decrease in the total grain boundary energy.
C1 [Allen, J. B.] US Army Engineer Res & Dev Ctr, Informat Technol Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
RP Allen, JB (reprint author), US Army Engineer Res & Dev Ctr, Informat Technol Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
EM Jeffrey.B.Allen@erdc.dren.mil
NR 24
TC 0
Z9 0
U1 1
U2 1
PU ASME
PI NEW YORK
PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA
SN 0094-4289
EI 1528-8889
J9 J ENG MATER-T ASME
JI J. Eng. Mater. Technol.-Trans. ASME
PD OCT
PY 2016
VL 138
IS 4
AR 041012
DI 10.1115/1.4033908
PG 9
WC Engineering, Mechanical; Materials Science, Multidisciplinary
SC Engineering; Materials Science
GA EE6ZE
UT WOS:000389762500012
ER
PT J
AU Urban, N
Boivin, MR
Cowan, DN
AF Urban, N.
Boivin, M. R.
Cowan, D. N.
TI Fitness, obesity and risk of asthma among Army trainees
SO OCCUPATIONAL MEDICINE-OXFORD
LA English
DT Article
DE Asthma; body fat; fitness test; military; obesity
ID ADULT-ONSET ASTHMA; PHYSICAL-FITNESS; CIGARETTE-SMOKING; INCIDENT
ASTHMA; SURVEILLANCE; OVERWEIGHT; ADIPOSITY; INJURIES; WOMEN
AB Background Epidemiological data suggest an association between overweight/obesity and asthma. However, less is known about the relationship between physical fitness and asthma.
Aims To enumerate new-onset asthma diagnoses in Army recruits during the first 2 years of service and determine associations with fitness and excess body fat (EBF) at military entrance.
Methods New asthma diagnoses over 2 years in Army recruits at six entrance stations were obtained from military health and personnel records. Poisson regression models were used to determine associations of asthma diagnosis with pre-accession fitness testing, EBF and other potential factors.
Results In 9979 weight-qualified and 1117 EBF entrants with no prior history of asthma, 256 new cases of asthma were diagnosed within 2 years of military entry. Low level of fitness, defined by a step test and EBF, was significantly associated with new asthma diagnosis [adjusted incidence rate ratio (IRR), 1.47; 95% confidence interval (CI) 1.11-1.96 and adjusted IRR, 1.53; 95% CI 1.06-2.20, respectively].
Conclusions Individuals with low fitness levels, EBF or both are at higher risk of asthma diagnosis in the first 2 years of military service.
C1 [Urban, N.; Boivin, M. R.; Cowan, D. N.] Walter Reed Army Inst Res, Prevent Med, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
[Urban, N.; Cowan, D. N.] ManTech Adv Syst Int Inc, 12015 Lee Jackson Highway, Fairfax, VA 22033 USA.
RP Cowan, DN (reprint author), Walter Reed Army Inst Res, Prevent Med, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM david.n.cowan.ctr@mail.mil
FU US Army Accession Command
FX US Army Accession Command.
NR 28
TC 0
Z9 0
U1 2
U2 2
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0962-7480
EI 1471-8405
J9 OCCUP MED-OXFORD
JI Occup. Med.-Oxf.
PD OCT
PY 2016
VL 66
IS 7
BP 551
EP 557
DI 10.1093/occmed/kqw081
PG 7
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA EF4MF
UT WOS:000390301900011
PM 27387918
ER
PT J
AU Pinho-Costa, L
Yakubu, K
Hoedebecke, K
Laranjo, L
Reichel, CP
Colon-Gonzalez, MD
Neves, AL
Errami, H
AF Pinho-Costa, Luis
Yakubu, Kenneth
Hoedebecke, Kyle
Laranjo, Liliana
Reichel, Christofer Patrick
Colon-Gonzalez, Maria del C.
Neves, Ana Luisa
Errami, Hassna
TI Healthcare hashtag index development: Identifying global impact in
social media
SO JOURNAL OF BIOMEDICAL INFORMATICS
LA English
DT Article
DE Bibliometrics; Internet; Social media; Family practice; Primary health
care
ID TWITTER
AB Purpose: Create an index of global reach for healthcare hashtags and tweeters therein, filterable by topic of interest.
Materials and methods: For this proof-of-concept study we focused on the field of Primary Care and Family Medicine. Six hashtags were selected based on their importance, from the ones included in the 'Healthcare Hashtag Project'. Hashtag Global Reach (HGR) was calculated using the additive aggregation of five weighted, normalized indicator variables: number of impressions, tweets, tweeters, user locations, and user languages. Data were obtained for the last quarter of 2014 and first quarter of 2015 using Symplur Signals. Topic-specific HGR were calculated for the top 10 terms and for sets of quotes mapped after a thematic analysis. Individual Global Reach, IGR, was calculated across hashtags as additive indexes of three indicators: replies, retweets and mentions.
Results: Using the HGR score we were able to rank six selected hashtags and observe their performance throughout the study period. We found that #PrimaryCare and #FMRevolution had the highest HGR score in both quarters; interestingly, #FMChangeMakers experienced a marked increase in its global visibility during the study period. "Health Policy" was the commonest theme, while "Care", "Family" and "Health" were the most common terms.
Discussion: This is the first study describing an altmetric hashtag index. Assuming analytical soundness, the Index might prove generalizable to other healthcare hashtags. If released as a real-time business intelligence tool with customizable settings, it could aid publishing and strategic decisions by netizens, organizations, and analysts. IGR could also serve to augment academic evaluation and professional development.
Conclusion: Our study demonstrates the feasibility of using an index on the global reach of healthcare hashtags and tweeters. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Pinho-Costa, Luis] Fanzeres Family Hlth Unit, Praceta da Barrosa S-N, P-4510513 Fanzeres, Gondomar, Portugal.
[Yakubu, Kenneth] Univ Jos, Dept Family Med, PMB 2076, Jos, Plateau State, Nigeria.
[Yakubu, Kenneth] Univ Jos, Teaching Hosp, PMB 2076, Jos, Plateau State, Nigeria.
[Hoedebecke, Kyle] Robinson Hlth Clin, Team 11722 Tagayta Dr, Ft Bragg, NC 28310 USA.
[Laranjo, Liliana] Macquarie Univ, Australian Inst Hlth Innovat, Ctr Hlth Informat, Level 6,75 Talavera Rd, Sydney, NSW 2109, Australia.
[Reichel, Christofer Patrick] Austrian Assoc Gen Practice & Family Med, Grenzgasse 11, A-3100 Polten, Austria.
[Colon-Gonzalez, Maria del C.] Univ Texas, Dept Family & Prevent Med, Rio Grande Valley 205 E Toronto Ave, Mcallen, TX 78503 USA.
[Neves, Ana Luisa] Univ Porto, Fac Med, Unit Family Med, Dept Social Sci & Hlth, P-4100 Oporto, Portugal.
[Errami, Hassna] Cabinet Med Aygalades, 57 Chemin St Antoine St Joseph, F-13015 Marseille, France.
RP Pinho-Costa, L (reprint author), Fanzeres Family Hlth Unit, Praceta da Barrosa S-N, P-4510513 Fanzeres, Gondomar, Portugal.
EM luisdepinhocosta@gmail.com
OI Yakubu, Kenneth/0000-0002-5385-0143
NR 34
TC 1
Z9 1
U1 2
U2 2
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1532-0464
EI 1532-0480
J9 J BIOMED INFORM
JI J. Biomed. Inform.
PD OCT
PY 2016
VL 63
BP 390
EP 399
DI 10.1016/j.jbi.2016.09.010
PG 10
WC Computer Science, Interdisciplinary Applications; Medical Informatics
SC Computer Science; Medical Informatics
GA EE4FF
UT WOS:000389557000038
PM 27645323
ER
PT J
AU Contopoulos-Ioannidis, D
Tseretopoulou, X
Ancker, M
Walterspiel, JN
Panagiotou, OA
Maldonado, Y
Ioannidis, JPA
AF Contopoulos-Ioannidis, Despina
Tseretopoulou, Xanthippi
Ancker, Megan
Walterspiel, Juan N.
Panagiotou, Orestis A.
Maldonado, Yvonne
Ioannidis, John P. A.
TI Comparative rates of harms in randomized trials from more developed
versus less developed countries may be different
SO JOURNAL OF CLINICAL EPIDEMIOLOGY
LA English
DT Review
DE Comparative safety; Comparative harms; More developed countries; Less
developed countries; Randomized trials; Meta-analyses
ID CLINICAL-TRIALS; SYSTEMATIC REVIEWS; MEDICAL INTERVENTIONS; ADVERSE
EVENTS; METAANALYSES; QUALITY; SAFETY; HEALTH; HETEROGENEITY; STATEMENT
AB Objectives: We set up to evaluate the relative risk of harms in trials performed in less developed vs. more developed countries.
Study Design and Setting: Meta-epidemiologic evaluation using the Cochrane Database of Systematic Reviews. We considered meta analyses with at least one randomized clinical trial (RCT) in a less developed country and one RCT in a more developed country. We targeted severe adverse events (AEs), discontinuations due to AEs, any AE, organ system-specific AEs, individual AEs, and all discontinuations due to any reason. We estimated the relative odds ratio (ROR) of harms between more and less developed countries for each topic and the summary ROR (sROR) across topics under each category of harms.
Results: We identified 42 systematic reviews (128 meta-analyses, 521 independent RCTs). Summary sRORs did not differ significantly from 1.00 for any harm category. Nominally significant RORs were found in only 6/128 meta-analyses. However, in 27% (35/128) of meta analyses the ROR point estimates indicated relative differences between country settings > 2-fold. Considering also ROR 95% confidence intervals, in 92% (118/128) of meta-analyses one could not exclude a 2-fold difference in both directions.
Conclusions: We identified limited comparative evidence on harms in trials from these two country settings. Substantial differences in the risk point estimates were common; the potential for modest differences could rarely be excluded with confidence. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Contopoulos-Ioannidis, Despina; Maldonado, Yvonne] Stanford Univ, Sch Med, Div Infect Dis, Dept Pediat, 300 Pasteur Dr,Room G312, Stanford, CA 94305 USA.
[Contopoulos-Ioannidis, Despina] Palo Alto Med Fdn, Res Inst, 795 El Camino Real,Ames Bldg,Room 2A027B, Palo Alto, CA 94301 USA.
[Contopoulos-Ioannidis, Despina; Ioannidis, John P. A.] Meta Res Innovat Ctr Stanford METRICS, 1070 Arastradero Rd, Palo Alto, CA 94304 USA.
[Tseretopoulou, Xanthippi] NHS Trust, Leeds Teaching Hosp, Great George St, Leeds LS1 3EX, W Yorkshire, England.
[Ancker, Megan] Med San Frontieres, 8 Rue St Sabin, F-75011 Paris, France.
[Walterspiel, Juan N.] Mendocino Coast Dist Hosp, 700 River Dr, Ft Bragg, CA 95437 USA.
[Panagiotou, Orestis A.] NCI, Div Canc Epidemiol & Genet, NIH, 9609 Med Ctr Dr,Room 7E136, Bethesda, MD 20892 USA.
[Maldonado, Yvonne; Ioannidis, John P. A.] Stanford Univ, Sch Med, Dept Hlth Res & Policy, Redwood Bldg TI52,150 Governors Lane, Stanford, CA 94305 USA.
[Maldonado, Yvonne] Stanford Univ, Sch Med, Fac Dev & Divers, 291 Campus Dr, Stanford, CA 94305 USA.
[Ioannidis, John P. A.] Stanford Univ, Sch Med, Dept Med, Stanford Prevent Res Ctr, Med Sch Off Bldg,1265 Welch Rd, Stanford, CA 94305 USA.
[Ioannidis, John P. A.] Stanford Univ, Dept Stat, Sch Humanities & Sci, Sequoia Hall,390 Serra Mall, Stanford, CA 94305 USA.
RP Contopoulos-Ioannidis, D (reprint author), Stanford Univ, Sch Med, Div Infect Dis, Dept Pediat, 300 Pasteur Dr,Room G312, Stanford, CA 94305 USA.
EM dcontop@stanford.edu
NR 36
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0895-4356
EI 1878-5921
J9 J CLIN EPIDEMIOL
JI J. Clin. Epidemiol.
PD OCT
PY 2016
VL 78
BP 10
EP 21
DI 10.1016/j.jclinepi.2016.02.032
PG 12
WC Health Care Sciences & Services; Public, Environmental & Occupational
Health
SC Health Care Sciences & Services; Public, Environmental & Occupational
Health
GA EE4ZV
UT WOS:000389615400004
PM 27063207
ER
PT J
AU Bridewell, VL
Karwacki, CJ
Kamat, PV
AF Bridewell, Victoria L.
Karwacki, Christopher J.
Kamat, Prashant V.
TI Electrocatalytic Sensing with Reduced Graphene Oxide: Electron Shuttling
between Redox Couples Anchored on a 2-D Surface
SO ACS SENSORS
LA English
DT Article
DE graphene oxide; electrocatalysis; electron shuttling; 2-D materials;
charge transfer; signal enhancement
ID ENVIRONMENTAL APPLICATIONS; PHOTOCATALYTIC REDUCTION; FUEL-CELLS;
NANOCOMPOSITES; ENERGY; FILMS; FUNCTIONALIZATION; ELECTROCHEMISTRY;
SUPERCAPACITORS; FABRICATION
AB The electron storage and shuttling capabilities of reduced graphene oxide (RGO) have been explored by anchoring two redox couples, methyl viologen (MV2+) and ferrocene (Fc). When an RGO modified glassy carbon electrode (GCE/RGO) was subjected to a cathodic scan, a quasi-reversible reduction of MV2+ was seen indicating a loss of electrons contributed to "charging" of RGO. These stored electrons can then be transported to oxidized Fc during the anodic scan through the C-C network of RGO. The recycling and peak current magnitude of oxidized and reduced forms of Fc during the anodic scan is strongly dependent on the scan rate, concentration, and extent of MV2+ reduction, either complete or partial, during the cathodic scan. This electrocatalytic property of RGO film enables the design of sensors and catalysts with the capacity to capture, store, and shuttle electrons and corroborate a boost in sensitivity for the electrochemical detection and conversion of low level analytes.
C1 [Bridewell, Victoria L.; Kamat, Prashant V.] Univ Notre Dame, Radiat Lab, Notre Dame, IN 46556 USA.
[Bridewell, Victoria L.; Kamat, Prashant V.] Univ Notre Dame, Dept Chem & Biochem, Notre Dame, IN 46556 USA.
[Karwacki, Christopher J.] US Army Res, Edgewood Chem Biol Ctr, Dev & Engn Command, 5183 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA.
RP Kamat, PV (reprint author), Univ Notre Dame, Radiat Lab, Notre Dame, IN 46556 USA.; Kamat, PV (reprint author), Univ Notre Dame, Dept Chem & Biochem, Notre Dame, IN 46556 USA.
EM pkamat@nd.edu
FU Army Research Office [ARO 64011-CH]; University of Wisconsin Materials
Research Science and Engineering Center, National Science Foundation
[DMR-1121288]; U.S. Department of Energy Office of Science, Office of
Basic Energy Sciences [DE-FC02-04ER15533]
FX The research described here was supported by the Army Research Office
through the award ARO 64011-CH. V.B. acknowledges the partial graduate
fellowship support received through the University of Wisconsin
Materials Research Science and Engineering Center, National Science
Foundation Grant DMR-1121288. The Notre Dame Radiation Laboratory is
supported by the U.S. Department of Energy Office of Science, Office of
Basic Energy Sciences under Award Number DE-FC02-04ER15533. This is a
document number 5126 from the Notre Dame Radiation Laboratory.
NR 43
TC 0
Z9 0
U1 10
U2 10
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 2379-3694
J9 ACS SENSORS
JI ACS Sens.
PD OCT
PY 2016
VL 1
IS 10
BP 1203
EP 1207
DI 10.1021/acssensors.6b00377
PG 5
WC Chemistry, Multidisciplinary; Nanoscience & Nanotechnology
SC Chemistry; Science & Technology - Other Topics
GA EA6OD
UT WOS:000386747600007
ER
PT J
AU Regeimbal, JM
Jacobs, AC
Corey, BW
Henry, MS
Thompson, MG
Pavlicek, RL
Quinones, J
Hannah, RM
Ghebremedhin, M
Crane, NJ
Zurawski, DV
Teneza-Mora, NC
Biswas, B
Hall, ER
AF Regeimbal, James M.
Jacobs, Anna C.
Corey, Brendan W.
Henry, Matthew S.
Thompson, Mitchell G.
Pavlicek, Rebecca L.
Quinones, Javier
Hannah, Ryan M.
Ghebremedhin, Meron
Crane, Nicole J.
Zurawski, Daniel V.
Teneza-Mora, Nimfa C.
Biswas, Biswajit
Hall, Eric R.
TI Personalized Therapeutic Cocktail of Wild Environmental Phages Rescues
Mice from Acinetobacter baumannii Wound Infections
SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
LA English
DT Article
ID BACTERIOPHAGE THERAPY; CAPSULAR POLYSACCHARIDE; GALLERIA-MELLONELLA;
MILITARY PERSONNEL; PRINCIPLES; MODEL; IRAQ; SUSCEPTIBILITY;
BIOSYNTHESIS; DEPOLYMERASE
AB Multidrug-resistant bacterial pathogens are an increasing threat to public health, and lytic bacteriophages have reemerged as a potential therapeutic option. In this work, we isolated and assembled a five-member cocktail of wild phages against Acinetobacter baumannii and demonstrated therapeutic efficacy in a mouse full-thickness dorsal infected wound model. The cocktail lowers the bioburden in the wound, prevents the spread of infection and necrosis to surrounding tissue, and decreases infection-associated morbidity. Interestingly, this effective cocktail is composed of four phages that do not kill the parent strain of the infection and one phage that simply delays bacterial growth in vitro via a strong but incomplete selection event. The cocktail here appears to function in a combinatorial manner, as one constituent phage targets capsulated A. baumannii bacteria and selects for loss of receptor, shifting the population to an uncapsulated state that is then sensitized to the remaining four phages in the cocktail. Additionally, capsule is a known virulence factor for A. baumannii, and we demonstrated that the emergent uncapsulated bacteria are avirulent in a Galleria mellonella model. These results highlight the importance of anticipating population changes during phage therapy and designing intelligent cocktails to control emergent strains, as well as the benefits of using phages that target virulence factors. Because of the efficacy of this cocktail isolated from a limited environmental pool, we have established a pipeline for developing new phage therapeutics against additional clinically relevant multidrug-resistant pathogens by using environmental phages sourced from around the globe.
C1 [Regeimbal, James M.; Pavlicek, Rebecca L.; Teneza-Mora, Nimfa C.; Hall, Eric R.] US Navy, Med Res Ctr, Wound Infect Dept, Silver Spring, MD USA.
[Jacobs, Anna C.; Corey, Brendan W.; Thompson, Mitchell G.; Zurawski, Daniel V.] Walter Reed Army Inst Res, Wound Infect Dept, Silver Spring, MD USA.
[Quinones, Javier; Biswas, Biswajit] US Navy, Med Res Ctr Frederick, Biol Def Res Directorate, Ft Detrick, MD 21702 USA.
[Hannah, Ryan M.] Natl Biodefense & Countermeasures Ctr, Natl Bioforens Anal Ctr, Ft Detrick, MD USA.
[Ghebremedhin, Meron] US Navy, Med Res Ctr, Regenerat Med Dept, Silver Spring, MD USA.
[Thompson, Mitchell G.] Univ Calif Berkeley, Berkeley, CA 94720 USA.
[Pavlicek, Rebecca L.] NAMRU Asia, Singapore, Singapore.
RP Biswas, B (reprint author), US Navy, Med Res Ctr Frederick, Biol Def Res Directorate, Ft Detrick, MD 21702 USA.
EM biswas.biswajit.ctr@mail.mil
RI Zurawski, Daniel/B-6578-2009
OI Zurawski, Daniel/0000-0002-7920-5601
FU Military Infectious Disease Research Program [W0121_14_NM]; U.S.
Department of Homeland Security (DHS) [HSHQDC-07-C-00020]
FX This work, including the efforts of James M. Regeimbal, Matthew S.
Henry, Rebecca L. Pavlicek, Javier Quinones, Nimfa C. Teneza-Mora,
Biswajit Biswas, and Eric R. Hall, was funded by Military Infectious
Disease Research Program (W0121_14_NM). This work, including the efforts
of Ryan M. Hannah, was funded by U.S. Department of Homeland Security
(DHS) (HSHQDC-07-C-00020).
NR 51
TC 1
Z9 1
U1 3
U2 3
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0066-4804
EI 1098-6596
J9 ANTIMICROB AGENTS CH
JI Antimicrob. Agents Chemother.
PD OCT
PY 2016
VL 60
IS 10
BP 5806
EP 5816
DI 10.1128/AAC.02877-15
PG 11
WC Microbiology; Pharmacology & Pharmacy
SC Microbiology; Pharmacology & Pharmacy
GA ED7PD
UT WOS:000389059800021
PM 27431214
ER
PT J
AU Wickham, KS
Baresel, PC
Marcsisin, SR
Sousa, J
Vuong, CT
Reichard, GA
Campo, B
Tekwani, BL
Walker, LA
Rochford, R
AF Wickham, Kristina S.
Baresel, Paul C.
Marcsisin, Sean R.
Sousa, Jason
Vuong, Chau T.
Reichard, Gregory A.
Campo, Brice
Tekwani, Babu L.
Walker, Larry A.
Rochford, Rosemary
TI Single-Dose Primaquine in a Preclinical Model of Glucose-6-Phosphate
Dehydrogenase Deficiency: Implications for Use in Malaria
Transmission-Blocking Programs
SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
LA English
DT Article
ID PLASMODIUM-FALCIPARUM; G6PD DEFICIENCY; PHARMACOKINETICS;
IDENTIFICATION; CHALLENGES; CLEARANCE; TOXICITY; CHILDREN; SAFETY; VIVAX
AB Individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency (G6PDd) are at risk for developing hemolytic anemia when given the antimalarial drug primaquine (PQ). The WHO Evidence Review Group released a report suggesting that mass administration of a single dose of PQ at 0.25 mg of base/kg of body weight (mpk) (mouse equivalent of 3.125 mpk) could potentially reduce malaria transmission based on its gametocytocidal activity and could be safely administered to G6PD-deficient individuals, but there are limited safety data available confirming the optimum single dose of PQ. A single-dose administration of PQ was therefore assessed in our huRBC-SCID mouse model used to predict hemolytic toxicity with respect to G6PD deficiency. In this model, nonobese diabetic (NOD)/SCID mice are engrafted with human red blood cells (huRBC) from donors with the African or Mediterranean variant of G6PDd (A-G6PDd or Med-G6PDd, respectively) and demonstrate dose-dependent sensitivity to PQ. In mice engrafted with A-G6PD-deficient huRBC, single-dose PQ at 3.125, 6.25, or 12.5 mpk had no significant loss of huRBC compared to the vehicle control group. In contrast, in mice engrafted with Med-G6PDd huRBC, a single dose of PQ at 3.125, 6.25, or 12.5 mpk resulted in a significant, dose-dependent loss of huRBC compared to the value for the vehicle control group. Our data suggest that administration of a single low dose of 0.25 mpk of PQ could induce hemolytic anemia in MedG6PDd individuals but that use of single-dose PQ at 0.25 mpk as a gametocytocidal drug to block transmission would be safe in areas where A-G6PDd predominates.
C1 [Wickham, Kristina S.; Baresel, Paul C.; Rochford, Rosemary] SUNY Upstate Med Univ, Dept Microbiol & Immunol, Syracuse, NY 13210 USA.
[Wickham, Kristina S.; Marcsisin, Sean R.; Sousa, Jason; Vuong, Chau T.; Reichard, Gregory A.] Walter Reed Army Inst Res, Mil Malaria Res Program, Expt Therapeut Branch, Silver Spring, MD USA.
[Campo, Brice] Med Malaria Venture, Geneva, Switzerland.
[Tekwani, Babu L.; Walker, Larry A.] Univ Mississippi, Natl Ctr Nat Prod Res, University, MS USA.
[Tekwani, Babu L.; Walker, Larry A.] Univ Mississippi, Sch Pharm, Dept Biomol Sci, University, MS 38677 USA.
[Baresel, Paul C.] Univ Vermont, Burlington, VT USA.
[Rochford, Rosemary] Univ Colorado, Dept Immunol & Microbiol, Denver, CO 80202 USA.
RP Rochford, R (reprint author), SUNY Upstate Med Univ, Dept Microbiol & Immunol, Syracuse, NY 13210 USA.
EM rosemary.rochford@ucdenver.edu
FU Medicines for Malaria Venture (MMV) [12/0007]; DOD \ United States Army
\ Medical Research and Materiel Command (MRMC) [W81XWH-10-2-0059,
WX81XWH-13-2-0026]; USDA-ARS [58-6408-2-0009]
FX This work, including the efforts of Rosemary Rochford, was funded by
Medicines for Malaria Venture (MMV) (12/0007). This work, including the
efforts of Larry A. Walker, was funded by DOD vertical bar United States
Army vertical bar Medical Research and Materiel Command (MRMC)
(W81XWH-10-2-0059 and WX81XWH-13-2-0026).; The National Center for
Natural Products Research (NCNPR) at the University of Mississippi is
also supported by USDA-ARS scientific cooperative agreement no.
58-6408-2-0009.
NR 32
TC 0
Z9 0
U1 1
U2 1
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0066-4804
EI 1098-6596
J9 ANTIMICROB AGENTS CH
JI Antimicrob. Agents Chemother.
PD OCT
PY 2016
VL 60
IS 10
BP 5906
EP 5913
DI 10.1128/AAC.00600-16
PG 8
WC Microbiology; Pharmacology & Pharmacy
SC Microbiology; Pharmacology & Pharmacy
GA ED7PD
UT WOS:000389059800031
PM 27458212
ER
PT J
AU Yu, JH
McWilliams, BA
Kaste, RP
AF Yu, J. H.
McWilliams, B. A.
Kaste, R. P.
TI Digital Image Correlation Analysis and Numerical Simulation of Aluminum
Alloys under Quasi-static Tension after Necking Using the Bridgman's
Correction Method
SO EXPERIMENTAL TECHNIQUES
LA English
DT Article
DE Digital image correlation; Materials Behaviors; Numerical Methods;
Optical Methods; Plasticity
ID STRESS-STRAIN CURVES; ELASTOPLASTIC CHARACTERIZATION; TRIAXIALITY;
FRACTURE; IDENTIFICATION; SPECIMENS; BEHAVIOR; FIELDS
AB Quasi-static tensile test is a common, yet fundamental, experiment in determining the mechanical properties of materials. Often, the determination of the equivalent stress-strain relation is complicated by strain localization and necking in the tensile specimen, which results in a triaxial stress state in the specimen and invalidates the assumption of uniaxial tension. In this paper, a three-dimensional full-field Digital Image Correction (DIC) technique is used to obtain all the necessary geometric properties of a cylindrical tensile specimen during necking that are required in determining the Bridgman's correction method to the true stress-strain relation. Finite element modeling is used to test the applicability of Bridgman's correctionmethod on three different aluminum alloys to quantify the effect of strain hardening on the triaxiality in the necked region.
C1 [Yu, J. H.; McWilliams, B. A.; Kaste, R. P.] US Army Res Lab, RDRL WMM B, Aberdeen Proving Ground, MD 21005 USA.
RP Yu, JH (reprint author), US Army Res Lab, RDRL WMM B, Aberdeen Proving Ground, MD 21005 USA.
EM jian.h.yu.civ@mail.mil
NR 22
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0732-8818
EI 1747-1567
J9 EXP TECHNIQUES
JI Exp. Tech.
PD OCT
PY 2016
VL 40
IS 5
BP 1359
EP 1367
DI 10.1007/s40799-016-0140-7
PG 9
WC Engineering, Mechanical; Mechanics; Materials Science, Characterization
& Testing
SC Engineering; Mechanics; Materials Science
GA ED4LA
UT WOS:000388818400001
ER
PT J
AU Woda, M
Friberg, H
Currier, JR
Srikiatkhachorn, A
Macareo, LR
Green, S
Jarman, RG
Rothman, AL
Mathew, A
AF Woda, Marcia
Friberg, Heather
Currier, Jeffrey R.
Srikiatkhachorn, Anon
Macareo, Louis R.
Green, Sharone
Jarman, Richard G.
Rothman, Alan L.
Mathew, Anuja
TI Dynamics of Dengue Virus (DENV)-Specific B Cells in the Response to DENV
Serotype 1 Infections, Using Flow Cytometry With Labeled Virions
SO JOURNAL OF INFECTIOUS DISEASES
LA English
DT Article
DE Dengue; B cell; antigen; flow cytometry; Alexa Fluor
ID ORIGINAL ANTIGENIC SIN; NEUTRALIZING ANTIBODIES; IMMUNE-RESPONSE;
HUMANS; PLASMABLASTS; PATHOGENESIS; VACCINE; PROTEIN; CLONES
AB Background. The development of reagents to identify and characterize antigen-specific B cells has been challenging.
Methods. We recently developed Alexa Fluor-labeled dengue viruses (AF DENVs) to characterize antigen-specific B cells in the peripheral blood of DENV-immune individuals.
Results. In this study, we used AF DENV serotype 1 (AF DENV-1) together with AF DENV-2 on peripheral blood mononuclear cells (PBMCs) from children in Thailand with acute primary or secondary DENV-1 infections to analyze the phenotypes of antigen-specific B cells that reflected their exposure or clinical diagnosis. DENV serotype-specific and cross-reactive B cells were identified in PBMCs from all subjects. Frequencies of AF DENV+ class-switched memory B cells (IgD(-)CD27(+) CD19(+) cells) reached up to 8% during acute infection and early convalescence. AF DENV-labeled B cells expressed high levels of CD27 and CD38 during acute infection, characteristic of plasmablasts, and transitioned into memory B cells (CD38(-)CD27(+)) at the early convalescent time point. There was higher activation of memory B cells early during acute secondary infection, suggesting reactivation from a previous DENV infection.
Conclusions. AF DENVs reveal changes in the phenotype of DENV serotype-specific and cross-reactive B cells during and after natural DENV infection and could be useful in analysis of the response to DENV vaccination.
C1 [Woda, Marcia; Srikiatkhachorn, Anon; Green, Sharone; Mathew, Anuja] Univ Massachusetts, Sch Med, Div Infect Dis & Immunol, Worcester, MA USA.
[Woda, Marcia; Rothman, Alan L.; Mathew, Anuja] Univ Rhode Isl, Inst Immunol & Informat, 825 Chalkstone Ave, Providence, RI 02908 USA.
[Friberg, Heather; Currier, Jeffrey R.; Jarman, Richard G.] Walter Reed Army Inst Res, Silver Spring, MD USA.
[Srikiatkhachorn, Anon; Macareo, Louis R.] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok, Thailand.
RP Mathew, A (reprint author), Inst Immunol & Informat, Dept Cell & Mol Biol, Rm 334B,80 Washington St, Providence, RI 02903 USA.
EM mathewa@uri.edu
FU National Institutes of Health [P01 AI34533, U19 AI57319, R21 AI113479];
Military Infectious Diseases Research Program
FX This work was supported by the National Institutes of Health (grants P01
AI34533, U19 AI57319, and R21 AI113479) and the Military Infectious
Diseases Research Program.
NR 33
TC 1
Z9 1
U1 3
U2 3
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0022-1899
EI 1537-6613
J9 J INFECT DIS
JI J. Infect. Dis.
PD OCT 1
PY 2016
VL 214
IS 7
BP 1001
EP 1009
DI 10.1093/infdis/jiw308
PG 9
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA DZ8RF
UT WOS:000386137800006
PM 27443614
ER
PT J
AU Song, SA
Tolisano, AM
Camacho, M
AF Song, Sunin A.
Tolisano, Anthony M.
Camacho, Macario
TI Laryngology Litigation in the United States: Thirty Years in Review
SO LARYNGOSCOPE
LA English
DT Review
DE Laryngology; malpractice; negligence
ID MEDICAL MALPRACTICE; SURGERY
AB Objectives/Hypothesis: Malpractice claims pertaining to laryngology procedures are a potentially important source of information that could be used to minimize the risk of future litigation and improve patient care.
Study Design: A retrospective review of two publicly available databases containing jury verdicts and settlements.
Methods: The LexisNexis Jury Verdicts and Settlements and Westlaw Next legal databases were reviewed for all lawsuits and out-of-court adjudications related to the practice of laryngology. Data including patient demographics, type of surgery performed, plaintiff allegation, nature of injury, outcomes, and indemnities were collected and analyzed.
Results: Of 87 cases meeting inclusion criteria, 56 were decided by a jury and 31 were adjudicated out of court. Vocal cord surgery was the most commonly litigated surgery. The two most commonly cited legal allegations were physical injury and negligence. No statistical difference for legal outcome was found when death or vocal cord injuries occurred. Complications in procedures that utilized a laser predicted an unfavorable outcome (P = 0.013). A payout was made in over one-half of cases, but defendants were favored in over two-thirds of cases decided by a jury. The average indemnities were significant for both jury verdicts ($ 4.6 million) and out-of-court settlements ($0.9 million).
Conclusion: An awareness of laryngology malpractice litigation has the potential to provide better patient care and help laryngologists avoid potential risks for litigation. The factors determining legal responsibility in laryngology cases underscore the importance of close communication with anesthesiologists and careful evaluation of hoarseness in all patients regardless of risk factors.
C1 [Song, Sunin A.; Tolisano, Anthony M.; Camacho, Macario] Tripler Army Med Ctr, Dept Otolaryngol Head & Neck Surg, 1 Jarrett White Rd, Honolulu, HI 96859 USA.
RP Song, SA (reprint author), Tripler Army Med Ctr, Dept Otolaryngol Head & Neck Surg, 1 Jarrett White Rd, Honolulu, HI 96859 USA.
EM sungjin.a.song.mil@mail.mil
NR 8
TC 1
Z9 1
U1 1
U2 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0023-852X
EI 1531-4995
J9 LARYNGOSCOPE
JI Laryngoscope
PD OCT
PY 2016
VL 126
IS 10
BP 2301
EP 2304
DI 10.1002/lary.25866
PG 4
WC Medicine, Research & Experimental; Otorhinolaryngology
SC Research & Experimental Medicine; Otorhinolaryngology
GA EA8ZZ
UT WOS:000386930800026
PM 26763607
ER
PT J
AU Pollak, KI
Fish, LJ
Lyna, P
Peterson, BL
Myers, ER
Gao, XM
Swamy, GK
Brown-Johnson, A
Whitecar, P
Bilheimer, AK
Pletsch, PK
AF Pollak, Kathryn I.
Fish, Laura J.
Lyna, Pauline
Peterson, Bercedis L.
Myers, Evan R.
Gao, Xiaomei
Swamy, Geeta K.
Brown-Johnson, Angela
Whitecar, Paul
Bilheimer, Alicia K.
Pletsch, Pamela K.
TI Efficacy of a Nurse-Delivered Intervention to Prevent and Delay
Postpartum Return to Smoking: The Quit for Two Trial
SO NICOTINE & TOBACCO RESEARCH
LA English
DT Article
ID PREGNANCY; CESSATION; WOMEN; PREDICTORS; ABSTINENCE; RELAPSE
AB Most pregnant women who quit smoking return to smoking postpartum. Trials to prevent this return have been unsuccessful. We tested the efficacy of a nurse-delivered intervention in maintaining smoking abstinence after delivery among pregnant women who quit smoking that was tailored on their high risk of relapse (eg, had strong intentions to return).
We recruited 382 English-speaking spontaneous pregnant quitters from 14 prenatal clinics and randomized them to receive either a smoking abstinence booklet plus newsletters about parenting and stress (control) or a nurse-delivered smoking abstinence intervention that differed in intensity for the high and low risk groups. Our primary outcome was smoking abstinence at 12 months postpartum.
Using intent-to-treat analyses, there was a high rate of biochemically validated smoking abstinence at 12 months postpartum but no arm differences (Control: 36% [95% confidence interval [CI]: 29-43] vs. Intervention: 35% [95% CI: 28-43], P = .81). Among women at low risk of returning to smoking, the crude abstinence rate was significantly higher in the control arm (46%) than in the intervention arm (33%); among women at high risk of returning to smoking, the crude abstinence rate was slightly lower but not different in the control arm (31%) than in the intervention arm (37%).
Low-risk women fared better with a minimal intervention that focused on parenting skills and stress than when they received an intensive smoking abstinence intervention. The opposite was true for women who were at high risk of returning to smoking. Clinicians might need to tailor their approach based on whether women are at high or low risk of returning to smoking.
Results suggest that high-risk and low-risk women might benefit from different types of smoking relapse interventions. Those who are lower risk of returning to smoking might benefit from stress reduction that is devoid of smoking content, whereas those who are higher risk might benefit from smoking relapse prevention.
C1 [Pollak, Kathryn I.; Lyna, Pauline; Gao, Xiaomei; Bilheimer, Alicia K.] Duke Canc Inst, Canc Control & Populat Sci, Durham, NC USA.
[Pollak, Kathryn I.; Fish, Laura J.] Duke Univ, Sch Med, Dept Community & Family Med, 2424 Erwin Rd,Suite 602, Durham, NC 27705 USA.
[Peterson, Bercedis L.] Duke Univ, Dept Biostat & Bioinformat, Durham, NC USA.
[Myers, Evan R.; Swamy, Geeta K.] Duke Univ, Sch Med, Dept Obstet & Gynecol, Durham, NC USA.
[Brown-Johnson, Angela; Whitecar, Paul] Womack Army Med Ctr, Dept Obstet & Gynecol, Ft Bragg, NC USA.
[Pletsch, Pamela K.] Univ Wisconsin, Sch Nursing, Madison, WI USA.
RP Pollak, KI (reprint author), Duke Univ, Sch Med, Dept Community & Family Med, 2424 Erwin Rd,Suite 602, Durham, NC 27705 USA.
EM kathryn.pollak@duke.edu
FU National Institutes of Health [R01NR009429]
FX This work was supported by the National Institutes of Health
(R01NR009429). The opinions and assentation's contained herein are the
private views of the authors and are not to be construed as official or
reflecting the views of the Department of the Army or the Department of
Defense.
NR 23
TC 0
Z9 0
U1 2
U2 2
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1462-2203
EI 1469-994X
J9 NICOTINE TOB RES
JI Nicotine Tob. Res.
PD OCT
PY 2016
VL 18
IS 10
BP 1960
EP 1966
DI 10.1093/ntr/ntw108
PG 7
WC Substance Abuse; Public, Environmental & Occupational Health
SC Substance Abuse; Public, Environmental & Occupational Health
GA DZ9NC
UT WOS:000386201100006
PM 27091830
ER
PT J
AU Knapik, JJ
Jean, RT
Austin, KG
Steelman, RA
Gannon, J
Farina, EK
Lieberman, HR
AF Knapik, Joseph J.
Jean, Rosenie T.
Austin, Krista G.
Steelman, Ryan A.
Gannon, Julia
Farina, Emily K.
Lieberman, Harris R.
TI Temporal trends in dietary supplement prescriptions of United States
military service members suggest a decrease in pyridoxine and increase
in vitamin D supplements from 2005 to 2013
SO NUTRITION RESEARCH
LA English
DT Article
DE Multivitamins; Vitamins; Minerals; Antacids/absorbents; Iron
preparations; Cathartics/laxatives
ID NUTRITION EXAMINATION SURVEY; CARPAL-TUNNEL-SYNDROME; RANDOMIZED
CONTROLLED-TRIAL; HEART-DISEASE INCIDENCE; CARDIOVASCULAR-DISEASE;
COMMON-COLD; PRIMARY PREVENTION; C SUPPLEMENTATION; NATIONAL-HEALTH;
CLINICAL-TRIAL
AB Dietary supplements (DSs) can be obtained over-the-counter but can also be prescribed by health-care providers for therapeutic reasons. Few studies have documented this later source despite the fact that 79% of physicians and 82% of nurses have recommended DSs to patients. This investigation assessed prevalence and temporal trends in oral DS prescriptions filled by all United States service members (SMs) from 2005 to 2013 (n = 1 427 080 +/- 22 139, mean +/- standard deviation (SD)/y). We hypothesize that there would be temporal variations in specific types of DSs. Data obtained from Department of Defense Pharmacy Data Transaction System were grouped by American Hospital Formulary System pharmacologic-therapeutic classifications and prevalence examined over time. About 11% of SMs filled one or more DS prescriptions of 235 180 +/- 4926 (mean +/- SD) prescriptions/y over the 9 -year period. Curve -fitting techniques indicated significant linear declines over time for multivitamins (P = .004), iron preparations (P < .001), antacids (P < .001), and vitamin B and B complex vitamins (P < .001). There were significant quadratic trends indicating a rise in early years followed by a leveling off in later years for replacement preparations (P < .001) and vitamin C (P < .001). There were significant quadratic trends (P < .001) for vitamin E indicating a decline in early years and leveling off in later years, and vitamin D indicating little change in early years followed by a large rise subsequently (P < .001). This study identified temporal trends in specific DS categories that may be associated with changing perceptions of prescribers and/or patients of the appropriate roles of DSs in medicine and public health. Published by Elsevier Inc.
C1 [Knapik, Joseph J.; Austin, Krista G.; Farina, Emily K.; Lieberman, Harris R.] US Army, Environm Med Res Inst, 10 Gen Greene Ave USARIEM, Natick, MA 01760 USA.
[Knapik, Joseph J.; Steelman, Ryan A.] US Army, Publ Hlth Ctr, Aberdeen Proving Ground, MD 21010 USA.
[Knapik, Joseph J.; Austin, Krista G.; Farina, Emily K.] Oak Ridge Inst Sci & Educ, Belcamp, MD 21017 USA.
[Jean, Rosenie T.; Gannon, Julia] US Army, Surg Gen, Pharmacovigilance Ctr, Falls Church, VA 22041 USA.
RP Knapik, JJ (reprint author), US Army, Environm Med Res Inst, 10 Gen Greene Ave USARIEM, Natick, MA 01760 USA.; Knapik, JJ (reprint author), US Army, Publ Hlth Ctr, Aberdeen Proving Ground, MD 21010 USA.; Knapik, JJ (reprint author), Oak Ridge Inst Sci & Educ, Belcamp, MD 21017 USA.
EM joseph.j.knapik.ctr@mail.mil; rosenie.thelus.civ@mail.mil;
krista.g.austin.ctr@mail.mil; ryan.a.steelman.ctr@mail.mil;
julia.f.gannon.civ@mail.mil; emily.k.farina.ctr@mail.mil;
harris.r.lieberman.civ@mail.mil
OI Knapik, Joseph/0000-0002-1568-1860
FU US Army Research Institute of Environmental Medicine (USARIEM); Army
Institute of Public Health; Center Alliance for Nutrition and Dietary
Supplement Research
FX Thanks to Angie Cost from the Armed Forces Health Surveillance Branch of
the Defense Health Agency for providing denominators that allowed
calculation of prevalences. This research was supported in part by an
appointment to the Knowledge Preservation Program at the US Army
Research Institute of Environmental Medicine (USARIEM) and the Army
Institute of Public Health administered by the Oak Ridge Institute for
Science and Education through an interagency agreement between the US
Department of Energy and USARIEM. Funding was also provided by the
Center Alliance for Nutrition and Dietary Supplement Research. No author
has a conflict of interest.
NR 109
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Z9 1
U1 9
U2 9
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0271-5317
J9 NUTR RES
JI Nutr. Res.
PD OCT
PY 2016
VL 36
IS 10
BP 1140
EP 1152
DI 10.1016/j.nutres.2016.09.001
PG 13
WC Nutrition & Dietetics
SC Nutrition & Dietetics
GA EE0SG
UT WOS:000389288600011
PM 27865356
ER
PT J
AU DiMase, D
Collier, ZA
Carlson, J
Gray, RB
Linkov, I
AF DiMase, Daniel
Collier, Zachary A.
Carlson, Jinae
Gray, Robin B., Jr.
Linkov, Igor
TI Traceability and Risk Analysis Strategies for Addressing Counterfeit
Electronics in Supply Chains for Complex Systems
SO RISK ANALYSIS
LA English
DT Article
DE Counterfeit; semiconductors; supply chain risk management; traceability
ID INTEGRATED-CIRCUITS; MANAGEMENT
AB Within the microelectronics industry, there is a growing concern regarding the introduction of counterfeit electronic parts into the supply chain. Even though this problem is widespread, there have been limited attempts to implement risk-based approaches for testing and supply chain management. Supply chain risk management tends to focus on the highly visible disruptions of the supply chain instead of the covert entrance of counterfeits; thus counterfeit risk is difficult to mitigate. This article provides an overview of the complexities of the electronics supply chain, and highlights some gaps in risk assessment practices. In particular, this article calls for enhanced traceability capabilities to track and trace parts at risk through various stages of the supply chain. Placing the focus on risk-informed decision making through the following strategies is needed, including prioritization of high-risk parts, moving beyond certificates of conformance, incentivizing best supply chain management practices, adoption of industry standards, and design and management for supply chain resilience.
C1 [DiMase, Daniel; Carlson, Jinae] Honeywell, Phoenix, AZ USA.
[Collier, Zachary A.; Linkov, Igor] US Army Engineer Res & Dev Ctr, Concord, MA 01742 USA.
[Gray, Robin B., Jr.] ECIA, Alpharetta, GA USA.
RP Linkov, I (reprint author), US Army Engineer Res & Dev Ctr, Concord, MA 01742 USA.
EM Igor.Linkov@usace.army.mil
NR 46
TC 0
Z9 0
U1 7
U2 7
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0272-4332
EI 1539-6924
J9 RISK ANAL
JI Risk Anal.
PD OCT
PY 2016
VL 36
IS 10
BP 1834
EP 1843
DI 10.1111/risa.12536
PG 10
WC Public, Environmental & Occupational Health; Mathematics,
Interdisciplinary Applications; Social Sciences, Mathematical Methods
SC Public, Environmental & Occupational Health; Mathematics; Mathematical
Methods In Social Sciences
GA ED6RZ
UT WOS:000388984900002
PM 26800103
ER
PT J
AU Scott, RP
Cullen, AC
Fox-Lent, C
Linkov, I
AF Scott, Ryan P.
Cullen, Alison C.
Fox-Lent, Cate
Linkov, Igor
TI Can Carbon Nanomaterials Improve CZTS Photovoltaic Devices? Evaluation
of Performance and Impacts Using Integrated Life-Cycle Assessment and
Decision Analysis
SO RISK ANALYSIS
LA English
DT Article
DE Emerging technologies; graphene; life-cycle impact assessment;
multi-criteria decision analysis; nanotechnology
ID SOLAR-CELLS; GRAPHENE; NANOTUBES; RISKS; FILMS
AB In emergent photovoltaics, nanoscale materials hold promise for optimizing device characteristics; however, the related impacts remain uncertain, resulting in challenges to decisions on strategic investment in technology innovation. We integrate multi-criteria decision analysis (MCDA) and life-cycle assessment (LCA) results (LCA-MCDA) as a method of incorporating values of a hypothetical federal acquisition manager into the assessment of risks and benefits of emerging photovoltaic materials. Specifically, we compare adoption of copper zinc tin sulfide (CZTS) devices with molybdenum back contacts to alternative devices employing graphite or graphene instead of molybdenum. LCA impact results are interpreted alongside benefits of substitution including cost reductions and performance improvements through application of multi-attribute utility theory. To assess the role of uncertainty we apply Monte Carlo simulation and sensitivity analysis. We find that graphene or graphite back contacts outperform molybdenum under most scenarios and assumptions. The use of decision analysis clarifies potential advantages of adopting graphite as a back contact while emphasizing the importance of mitigating conventional impacts of graphene production processes if graphene is used in emerging CZTS devices. Our research further demonstrates that a combination of LCA and MCDA increases the usability of LCA in assessing product sustainability. In particular, this approach identifies the most influential assumptions and data gaps in the analysis and the areas in which either engineering controls or further data collection may be necessary.
C1 [Scott, Ryan P.; Cullen, Alison C.] Univ Washington, Daniel J Evans Sch Publ Policy & Governance, Box 353055, Seattle, WA 98195 USA.
[Scott, Ryan P.; Fox-Lent, Cate; Linkov, Igor] US Army Corps Engineers, Engineer Res & Dev Ctr, Environm Lab, Concord, MA USA.
RP Scott, RP (reprint author), Univ Washington, Daniel J Evans Sch Publ Policy & Governance, Box 353055, Seattle, WA 98195 USA.
EM ryscott5@uw.edu
FU National Science Foundation [CHE-1230615]; U.S. Army Corps of Engineers;
Eunice Kennedy Shriver National Institute of Child Health and Human
Development [R24 HD042828]
FX This work was completed as part of the U.S. Army Engineer Research and
Development Center Summer Internship Program. We additionally would like
to thank Dr. Hugh Hillhouse and Wesley Williamson for their support in
providing case study material. This research was supported in part by
the National Science Foundation under Grant Number CHE-1230615. This
research also received core funding from the nanotechnology and
life-cycle assessment focus areas of the U.S. Army Corps of Engineers.
Additionally, partial support for analysis and computing came from a
Eunice Kennedy Shriver National Institute of Child Health and Human
Development research infrastructure grant, R24 HD042828, to the Center
for Studies in Demography & Ecology at the University of Washington.
Publication of this material has been approved by authority of the Chief
of the U.S. Army Corps of Engineers.
NR 44
TC 0
Z9 0
U1 8
U2 8
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0272-4332
EI 1539-6924
J9 RISK ANAL
JI Risk Anal.
PD OCT
PY 2016
VL 36
IS 10
BP 1916
EP 1935
DI 10.1111/risa.12539
PG 20
WC Public, Environmental & Occupational Health; Mathematics,
Interdisciplinary Applications; Social Sciences, Mathematical Methods
SC Public, Environmental & Occupational Health; Mathematics; Mathematical
Methods In Social Sciences
GA ED6RZ
UT WOS:000388984900007
PM 26800227
ER
PT J
AU Mohammad, MK
Pepper, DJ
Kedar, A
Bhaijee, F
Familoni, B
Rashed, H
Cutts, T
Abell, TL
AF Mohammad, Mohammad Khalid
Pepper, Dominique J.
Kedar, Archana
Bhaijee, Feriyl
Familoni, Babajide
Rashed, Hani
Cutts, Teresa
Abell, Thomas L.
TI Measures of Autonomic Dysfunction in Diabetic and Idiopathic
Gastroparesis
SO GASTROENTEROLOGY RESEARCH
LA English
DT Article
DE Gastroparesis; Diabetes; Autonomic nervous system; Sympathetic function;
Vagal dysfunction
ID MANAGEMENT; MELLITUS
AB Background: Gastroparesis is a condition classically characterized by delayed gastric emptying and is associated with considerable morbidity. While the etiology of gastroparesis remains elusive, autonomic dysfunction may play an important role, especially as many patients with gastroparesis also have diabetes. The aim of this study was to determine whether measures of autonomic function differ between adults with diabetic gastroparesis (DG) and adults with idiopathic gastroparesis (IG).
Methods: Tests of systemic autonomic function were performed among 20 adults with GD (six men and 14 women, mean age: 42 years) and 21 adults with IG (seven men and 14 women, mean age: 37 years). Measures included vagal cholinergics by R-R interval percentage variation (RRI-PV) and sympathetic adrenergics by vasoconstriction to cold (VC) and postural adjustment ratio (PAR). The two groups were compared using Wilcoxon rank sum tests and linear regression analysis (STATA 10.0).
Results: In univariate analysis, the following autonomic measures differed significantly between DG and IG: VC (P = 0.004), PAR (P = 0.045), VC + PAR (P = 0.002) and RRI-PV (P < 0.001). In multivariate analysis (P = 0.002, R-2 = 0.55), only RRI-PV (adjusted odds ratio (aOR): 1.02, 95% confidence interval (CI): 1.01 - 1.03) differed significantly between DG and IG patients.
Conclusions: Vagal cholinergics are affected to a greater degree in DG compared to IG, suggesting that impaired vagal tone is not a universal mechanism for gastroparesis.
C1 [Mohammad, Mohammad Khalid; Kedar, Archana; Abell, Thomas L.] Univ Louisville, Dept Med, Div Gastroenterol Hepatol & Nutr, 550 S Jackson St,ACB3 A3L15, Louisville, KY 40202 USA.
[Pepper, Dominique J.] Univ Mississippi, Med Ctr, Dept Med, Jackson, MS 39216 USA.
[Pepper, Dominique J.] NIH, Dept Crit Care Med, Bethesda, MD 20892 USA.
[Bhaijee, Feriyl] AmeriPath Indiana, Indianapolis, IN USA.
[Familoni, Babajide] US Army, Res Dev & Engn Command, NVESD, Ft Belvoir, VA USA.
[Rashed, Hani] Methodist Univ Hosp, Neurosci Inst & Canc Ctr, Memphis, TN USA.
[Cutts, Teresa] Wake Forest Sch Med, Div Publ Hlth, Winston Salem, NC USA.
RP Abell, TL (reprint author), Univ Louisville, Dept Med, Div Gastroenterol Hepatol & Nutr, 550 S Jackson St,ACB3 A3L15, Louisville, KY 40202 USA.
EM thomas.abell@louisville.edu
NR 19
TC 0
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U1 0
U2 0
PU ELMER PRESS INC
PI QUEBEC
PA 9160 BOUL LEDUC, BUREAU 410, BROSSARD, QUEBEC, J4Y 0E3, CANADA
SN 1918-2805
EI 1918-2813
J9 GASTROENTEROL RES
JI Gasteroenterol. Res.
PD OCT
PY 2016
VL 9
IS 4-5
BP 65
EP 69
DI 10.14740/gr713w
PG 5
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA ED2OZ
UT WOS:000388688500001
PM 27785328
ER
PT J
AU Yu, J
Gong, Y
Yuan, L
Xue, C
Chen, W
Giaddui, TG
Wu, QRJ
Lukka, H
Kudchadker, R
Seaward, SA
Gopaul, DD
Michalski, JM
Kaplan, ID
Beliveau-Nadeau, D
Stall, BR
Beyer, DC
Ma, CMC
Dayes, IS
Pinover, WH
Xiao, Y
AF Yu, J.
Gong, Y.
Yuan, L.
Xue, C.
Chen, W.
Giaddui, T. G.
Wu, Q. R. J.
Lukka, H.
Kudchadker, R.
Seaward, S. A.
Gopaul, D. D.
Michalski, J. M.
Kaplan, I. D.
Beliveau-Nadeau, D.
Stall, B. R.
Beyer, D. C.
Ma, C. M. C.
Dayes, I. S.
Pinover, W. H.
Xiao, Y.
TI Investigation Into the Feasibility of Having Uniform Compliance
Dosimetric Criteria Across Radiation Therapy Treatment Modalities for
NRG Oncology/RTOG 0938 by Using Machine Learning
SO INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
LA English
DT Meeting Abstract
CT 58th Annual Meeting of the American-Society-for-Radiation-Oncology
CY SEP 25-28, 2016
CL Boston, MA
SP Amer Soc Radiat Oncol
C1 [Yu, J.] Georgetown Univ Hosp, Washington, DC 20007 USA.
[Gong, Y.; Xue, C.; Chen, W.; Giaddui, T. G.] Thomas Jefferson Univ, Philadelphia, PA 19107 USA.
[Yuan, L.; Wu, Q. R. J.] Duke Univ, Med Ctr, Durham, NC USA.
[Lukka, H.] Hamilton Hlth Sci, Juravinski Canc Ctr, Hamilton, ON, Canada.
[Kudchadker, R.] Univ Texas MD Anderson Canc Ctr, Div Radiat Oncol, Houston, TX 77030 USA.
[Seaward, S. A.] Kaiser Permanente Northern Calif, Santa Clara, CA USA.
[Gopaul, D. D.] Grand River Reg Canc Ctr, Kitchener, ON, Canada.
[Michalski, J. M.] Washington Univ, Sch Med, St Louis, MO USA.
[Kaplan, I. D.] Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA.
[Beliveau-Nadeau, D.] Ctr Hosp Univ Montreal, Montreal, PQ, Canada.
[Stall, B. R.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA.
[Beyer, D. C.] Canc Ctr Northern Arizona, Sedona, AZ USA.
[Ma, C. M. C.] Fox Chase Canc Ctr, 7701 Burholme Ave, Philadelphia, PA 19111 USA.
[Dayes, I. S.] McMaster Univ, Hamilton, ON, Canada.
[Pinover, W. H.] Abington Mem Hosp, Abington, PA 19001 USA.
[Xiao, Y.] Univ Penn, Philadelphia, PA 19104 USA.
NR 0
TC 0
Z9 0
U1 3
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0360-3016
EI 1879-355X
J9 INT J RADIAT ONCOL
JI Int. J. Radiat. Oncol. Biol. Phys.
PD OCT 1
PY 2016
VL 96
IS 2
SU S
MA 2562
BP E230
EP E231
PG 2
WC Oncology; Radiology, Nuclear Medicine & Medical Imaging
SC Oncology; Radiology, Nuclear Medicine & Medical Imaging
GA EB8QL
UT WOS:000387655802561
ER
PT J
AU Chen, Z
Han, WJ
Yu, JG
Kecskes, L
Zhu, KG
Wei, QM
AF Chen, Zhe
Han, Wenjia
Yu, Jiangang
Kecskes, Laszlo
Zhu, Kaigui
Wei, Qiuming
TI Microstructure and helium irradiation performance of high purity
tungsten processed by cold rolling
SO JOURNAL OF NUCLEAR MATERIALS
LA English
DT Article
DE Rolling; Tungsten; Plasma facing materials; Irradiation
ID NANOCRYSTALLINE TUNGSTEN; RADIATION-DAMAGE; HYDROGEN; SINGLE;
NANOCOMPOSITES; INDENTATION; RESISTANCE; MECHANICS; ENERGY; MICRO
AB This work aims to investigate the effects of confined cold rolling on the evolution of microstructure, hardness, and helium irradiation performance of high purity tungsten (W). Using a final rolling temperature of 450 degrees C, W samples were severely deformed by confined cold rolling up to equivalent strains (epsilon(eq)) of 1.6 and 3.3. Experimental results indicate that the average grain size of W specimens processed by confined cold rolling has been greatly reduced, and the rolled W samples with epsilon(eq) similar to 3.3 do not show an "ideal texture" of (001)[ 110] which is the expected texture of bcc metals processed by conventional cold rolling. The irradiation resistance against 60 keV He+ ions with up to a dose of 1.5 x 10(22) ions.m(-2) of the rolled W is compared to that of the as-received W. Results show that, due to an improvement of the metal's ductility, blister bursting with a partially opened lid forms on the surface of the rolled W, whereas blister bursting with a fully opened lid forms on the surface of the as-received W. (C) 2016 Elsevier B.V. All rights reserved.
C1 [Chen, Zhe; Han, Wenjia; Yu, Jiangang; Zhu, Kaigui] Beihang Univ, Dept Phys, Beijing 100191, Peoples R China.
[Kecskes, Laszlo] US Army, Res Lab, WMRD, Aberdeen Proving Ground, MD 21005 USA.
[Chen, Zhe; Wei, Qiuming] Univ N Carolina, Dept Mech Engn, Charlotte, NC 28223 USA.
RP Zhu, KG (reprint author), Beihang Univ, Dept Phys, Beijing 100191, Peoples R China.; Wei, QM (reprint author), Univ N Carolina, Dept Mech Engn, Charlotte, NC 28223 USA.
EM kgzhu@buaa.edu.cn; qwei@uncc.edu
FU National Magnetic Confinement Fusion Programs [2013GB109003]; National
Natural Science Foundation of China [51171006, 51471015]; Chinese
Scholar Council (CSC); U.S. Army Research Laboratory [W911NF-14-2-0061]
FX The authors would like to thank Drs. Lu and Shen for their technical
assistance. This research is supported by National Magnetic Confinement
Fusion Programs with Grant No. 2013GB109003, and National Natural
Science Foundation of China with Grant Nos. 51171006 and 51471015. Z.
Chen would like to acknowledge the support from Chinese Scholar Council
(CSC) during his visit to UNC-Charlotte. Q. Wei is supported by the U.S.
Army Research Laboratory under Contract No. W911NF-14-2-0061.
NR 38
TC 0
Z9 0
U1 5
U2 5
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0022-3115
EI 1873-4820
J9 J NUCL MATER
JI J. Nucl. Mater.
PD OCT
PY 2016
VL 479
BP 418
EP 425
DI 10.1016/j.jnucmat.2016.07.038
PG 8
WC Materials Science, Multidisciplinary; Nuclear Science & Technology
SC Materials Science; Nuclear Science & Technology
GA DW3OX
UT WOS:000383552200052
ER
PT J
AU Crowell, TA
Robb, ML
AF Crowell, Trevor A.
Robb, Merlin L.
TI The doctor's dilemma and vaccine therapy for HIV
SO LANCET HIV
LA English
DT Editorial Material
ID ACTIVE ANTIRETROVIRAL THERAPY; PLACEBO-CONTROLLED TRIAL; CD4(+) T-CELLS;
CLINICAL-TRIAL; DOUBLE-BLIND; IMMUNIZATION; EFFICACY; SAFETY; GP160
C1 [Robb, Merlin L.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA.
Henry M Jackson Fdn Adv Mil Med, Bethesda, MD 20817 USA.
RP Robb, ML (reprint author), Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA.
EM mrobb@hivresearch.org
NR 16
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER INC
PI SAN DIEGO
PA 525 B STREET, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 2352-3018
J9 LANCET HIV
JI Lancet HIV
PD OCT
PY 2016
VL 3
IS 10
BP E450
EP E451
DI 10.1016/S2352-3018(16)30088-1
PG 2
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA ED7SY
UT WOS:000389072000002
PM 27658880
ER
PT J
AU Knapik, JJ
Trone, DW
McGraw, S
Steelman, RA
Austin, KG
Lieberman, HR
AF Knapik, Joseph J.
Trone, Daniel W.
McGraw, Susan
Steelman, Ryan A.
Austin, Krista G.
Lieberman, Harris R.
TI Caffeine Use among Active Duty Navy and Marine Corps Personnel
SO NUTRIENTS
LA English
DT Article
DE coffee; tea; cola; energy drink; alcohol; sleep; exercise; demographics;
lifestyle characteristics
ID ENERGY DRINK CONSUMPTION; MULTIVARIATE GENETIC-ANALYSIS; DOSE-RESPONSE
METAANALYSIS; COFFEE CONSUMPTION; COLLEGE-STUDENTS; BLOOD-PRESSURE;
UNITED-STATES; SOCIOECONOMIC-STATUS; MILLENNIUM COHORT; SLEEP DURATION
AB Data from the National Health and Nutrition Examination Survey (NHANES) indicate 89% of Americans regularly consume caffeine, but these data do not include military personnel. This cross-sectional study examined caffeine use in Navy and Marine Corps personnel, including prevalence, amount of daily consumption, and factors associated with use. A random sample of Navy and Marine Corps personnel was contacted and asked to complete a detailed questionnaire describing their use of caffeine-containing substances, in addition to their demographic, military, and lifestyle characteristics. A total of 1708 service members (SMs) completed the questionnaire. Overall, 87% reported using caffeinated beverages >= 1 time/week, with caffeine users consuming a mean +/- standard error of 226 +/- 5 mg/day (242 +/- 7 mg/day for men, 183 +/- 8 mg/day for women). The most commonly consumed caffeinated beverages (% users) were coffee (65%), colas (54%), teas (40%), and energy drinks (28%). Multivariable logistic regression modeling indicated that characteristics independently associated with caffeine use (>= 1 time/week) included older age, white race/ethnicity, higher alcohol consumption, and participating in less resistance training. Prevalence of caffeine use in these SMs was similar to that reported in civilian investigations, but daily consumption (mg/day) was higher.
C1 [Knapik, Joseph J.; McGraw, Susan; Austin, Krista G.; Lieberman, Harris R.] US Army, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA.
[Knapik, Joseph J.; Steelman, Ryan A.] US Army, Publ Hlth Ctr, Aberdeen Proving Ground, MD 21010 USA.
[Knapik, Joseph J.; Austin, Krista G.] Oak Ridge Inst Sci & Educ, Belcamp, MD 21017 USA.
[Trone, Daniel W.] Naval Hlth Res Ctr, San Diego, CA 92152 USA.
RP Knapik, JJ (reprint author), US Army, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA.; Knapik, JJ (reprint author), US Army, Publ Hlth Ctr, Aberdeen Proving Ground, MD 21010 USA.; Knapik, JJ (reprint author), Oak Ridge Inst Sci & Educ, Belcamp, MD 21017 USA.
EM joseph.j.knapik.ctr@mail.mil; daniel.w.trone.civ@mail.mil;
susan.m.mcgraw6.civ@mail.mil; ryan.a.steelman.ctr@mail.mil;
krista.g.austin.ctr@mail.mil; harris.r.lieberman.civ@mail.mil
FU appointment to the Knowledge Preservation Program at the US Army
Research Institute of Environmental Medicine (USARIEM); Army Public
Health Center (Provisional) (APHC-Prov); Bureau of Medicine and Surgery
[N1335]; Center Alliance for Dietary Supplement Research
FX This research was supported in part by an appointment to the Knowledge
Preservation Program at the US Army Research Institute of Environmental
Medicine (USARIEM) and the Army Public Health Center (Provisional)
(APHC-Prov) administered by the Oak Ridge Institute for Science and
Education through an interagency agreement between the US Department of
Energy, USARIEM, and APHC-Prov. This report was also supported by the
Bureau of Medicine and Surgery, under Work Unit No. N1335, and the
Center Alliance for Dietary Supplement Research.
NR 73
TC 0
Z9 0
U1 5
U2 5
PU MDPI AG
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 2072-6643
J9 NUTRIENTS
JI Nutrients
PD OCT
PY 2016
VL 8
IS 10
AR 620
DI 10.3390/nu8100620
PG 27
WC Nutrition & Dietetics
SC Nutrition & Dietetics
GA ED2HT
UT WOS:000388665300038
ER
PT J
AU Zakowski, MF
Rekhtman, N
Auger, M
Booth, CN
Crothers, B
Ghofrani, M
Khalbuss, W
Laucirica, R
Moriarty, AT
Tabatabai, ZL
Barkan, GA
AF Zakowski, Maureen F.
Rekhtman, Natasha
Auger, Manon
Booth, Christine N.
Crothers, Barbara
Ghofrani, Mohiddean
Khalbuss, Walid
Laucirica, Rodolfo
Moriarty, Ann T.
Tabatabai, Z. Laura
Barkan, Guliz A.
TI Morphologic Accuracy in Differentiating Primary Lung Adenocarcinoma From
Squamous Cell Carcinoma in Cytology Specimens
SO ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
LA English
DT Article
ID CANCER; HISTOLOGY; SUBTYPE
AB Context.-The National Cancer Care Network and the combined College of American Pathologists/International Association for the Study of Lung Cancer/Association for Molecular Pathology guidelines indicate that all lung adenocarcinomas (ADCs) should be tested for epidermal growth factor receptor (EGFR) mutations and anaplastic lymphoma kinase (ALK) rearrangements. As the majority of patients present at a later stage, the subclassification and molecular analysis must be done on cytologic material.
Objective.-To evaluate the accuracy and interobserver variability among cytopathologists in subtyping non-small cell lung carcinoma using cytologic preparations.
Design.-Nine cytopathologists from different institutions submitted cases of non-small cell lung carcinoma with surgical follow-up. Cases were independently, blindly reviewed by each cytopathologist. A diagnosis of ADC or squamous cell carcinoma was rendered based on the Diff-Quik, Papanicolaou, and hematoxylin-eosin stains. The specimen types included fine-needle aspiration from lung, lymph node, and bone; touch preparations from lung core biopsies; bronchial washings; and bronchial brushes. A major disagreement was defined as a case being misclassified 3 or more times.
Results.-Ninety-three cases (69 ADC, 24 squamous cell carcinoma) were examined. Of 818 chances (93 cases 3 9 cytopathologists) to correctly identify all the cases, 753 correct diagnoses were made (92% overall accuracy). Twenty-five of 69 cases of ADC (36%) and 7 of 24 cases of squamous cell carcinoma (29%) had disagreement (P = .16). Touch preparations were more frequently misdiagnosed compared with other specimens. Diagnostic accuracy of each cytopathologist varied from 78.4% to 98.7% (mean, 91.7%).
Conclusion.-Lung ADC can accurately be distinguished from squamous cell carcinoma by morphology in cytologic specimens with excellent interobserver concordance across multiple institutions and levels of cytology experience.
C1 [Zakowski, Maureen F.; Rekhtman, Natasha] Mem Sloan Kettering Canc Ctr, Dept Pathol, 1275 York Ave, New York, NY 10021 USA.
[Auger, Manon] Royal Victoria Hosp, Dept Pathol, Montreal, PQ, Canada.
[Booth, Christine N.] Cleveland Clin, Dept Pathol, Main Campus, Cleveland, OH 44106 USA.
[Crothers, Barbara] Walter Reed Army Med Ctr, Dept Pathol, Washington, DC 20307 USA.
[Ghofrani, Mohiddean] Peacehlth Lab, Dept Pathol, Vancouver, WA USA.
[Khalbuss, Walid] Univ Pittsburgh, Dept Pathol, Med Ctr Shadyside, Pittsburgh, PA USA.
[Laucirica, Rodolfo] Baylor Coll Med, Dept Pathol, Houston, TX 77030 USA.
[Moriarty, Ann T.] AmeriPath, Dept Pathol, Indianapolis, IN USA.
[Tabatabai, Z. Laura] Univ Calif San Francisco, Dept Pathol, San Francisco, CA 94140 USA.
[Barkan, Guliz A.] Loyola Univ, Med Ctr, Dept Pathol, 2160 South First Ave, Maywood, IL 60153 USA.
[Khalbuss, Walid] GE Clarient Diagnost Serv, Riyadh, Saudi Arabia.
RP Barkan, GA (reprint author), Loyola Univ, Med Ctr, Dept Pathol, 2160 South First Ave, Maywood, IL 60153 USA.
EM gbarkan@lumc.edu
NR 17
TC 0
Z9 0
U1 0
U2 0
PU COLL AMER PATHOLOGISTS
PI NORTHFIELD
PA C/O KIMBERLY GACKI, 325 WAUKEGAN RD, NORTHFIELD, IL 60093-2750 USA
SN 0003-9985
EI 1543-2165
J9 ARCH PATHOL LAB MED
JI Arch. Pathol. Lab. Med.
PD OCT
PY 2016
VL 140
IS 10
BP 1116
EP 1120
DI 10.5858/arpa.2015-0316-OA
PG 5
WC Medical Laboratory Technology; Medicine, Research & Experimental;
Pathology
SC Medical Laboratory Technology; Research & Experimental Medicine;
Pathology
GA EC7ZL
UT WOS:000388359600019
PM 27552093
ER
PT J
AU Rizzo, JA
Rowan, MP
Driscoll, IR
Chung, KK
Friedman, BC
AF Rizzo, Julie A.
Rowan, Matthew P.
Driscoll, Ian R.
Chung, Kevin K.
Friedman, Bruce C.
TI Vitamin C in Burn Resuscitation
SO CRITICAL CARE CLINICS
LA English
DT Article
DE Reactive oxygen species; Free radical; Ascorbic acid; Vitamin C; Burn
ID ABDOMINAL COMPARTMENT SYNDROME; ACUTE OXALATE NEPHROPATHY;
ASCORBIC-ACID; THERMAL-INJURY; LIPID-PEROXIDATION; FLUID VOLUME;
INTRAABDOMINAL HYPERTENSION; SUPEROXIDE-DISMUTASE; ANTIOXIDANT THERAPY;
DELAYED INITIATION
AB The inflammatory state after burn injury is characterized by an increase in capillary permeability that results in protein and fluid leakage into the interstitial space, increasing resuscitative requirements. Although the mechanisms underlying increased capillary permeability are complex, damage from reactive oxygen species plays a major role and has been successfully attenuated with antioxidant therapy in several disease processes. However, the utility of antioxidants in burn treatment remains unclear. Vitamin C is a promising antioxidant candidate that has been examined in burn resuscitation studies and shows efficacy in reducing the fluid requirements in the acute phase after burn injury.
C1 [Rizzo, Julie A.; Rowan, Matthew P.; Driscoll, Ian R.; Chung, Kevin K.] US Army, Inst Surg Res, 3698 Chambers Pass, Jbsa Ft Sam Houston, TX 78234 USA.
[Rizzo, Julie A.; Driscoll, Ian R.; Chung, Kevin K.] Uniformed Serv Univ Hlth Sci, Dept Surg, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.
[Friedman, Bruce C.] Doctors Hosp, JM Still Burn Ctr, 3651 Wheeler Rd, Augusta, GA 30909 USA.
RP Rizzo, JA (reprint author), US Army, Inst Surg Res, 3698 Chambers Pass, Jbsa Ft Sam Houston, TX 78234 USA.; Rizzo, JA (reprint author), Uniformed Serv Univ Hlth Sci, Dept Surg, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.
EM Julie.a.rizzo.mil@mail.mil
NR 42
TC 0
Z9 0
U1 0
U2 0
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0749-0704
EI 1557-8232
J9 CRIT CARE CLIN
JI Crit. Care Clin.
PD OCT
PY 2016
VL 32
IS 4
BP 539
EP +
DI 10.1016/j.ccc.2016.06.003
PG 9
WC Critical Care Medicine
SC General & Internal Medicine
GA EB9SS
UT WOS:000387738000007
PM 27600125
ER
PT J
AU Brownson, EG
Pham, TN
Chung, KK
AF Brownson, Elisha G.
Pham, Tam N.
Chung, Kevin K.
TI How to Recognize a Failed Burn Resuscitation
SO CRITICAL CARE CLINICS
LA English
DT Article
DE Burn; Resuscitation; Failed; Difficult; Runaway; Morbidity; Death
ID ABDOMINAL COMPARTMENT SYNDROME; DAMAGE CONTROL; INJURY; MORTALITY;
SURVIVAL; SUPPORT; SURGERY; ALBUMIN; LIFE; CARE
AB Failed burn resuscitation can occur at various points. Early failed resuscitation will be largely caused by prehospital factors. During resuscitation, failure will present as a patient's nonresponse to adjunctive therapy. Late failure will occur in the setting of multiple organ dysfunction syndrome. Burn care providers must be vigilant during the resuscitation to identify a threatened resuscitation so that adjunctive therapies or rescue maneuvers can be used to convert to a successful resuscitation. However, when a patient's resuscitative course becomes unsalvageable, transition to comfort care should be taken to avoid prolongation of suffering.
C1 [Brownson, Elisha G.; Pham, Tam N.] Harborview Med Ctr, Dept Surg, 325 Ninth Ave,Box 359796, Seattle, WA 98104 USA.
[Chung, Kevin K.] US Army, Inst Surg Res, 3698 Chambers Pass, Jbsa Ft Sam Houston, TX 78234 USA.
[Chung, Kevin K.] Uniformed Serv Univ Hlth Sci, Dept Surg, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.
RP Pham, TN (reprint author), Harborview Med Ctr, Dept Surg, 325 Ninth Ave,Box 359796, Seattle, WA 98104 USA.
EM tpham94@uw.edu
NR 29
TC 0
Z9 0
U1 0
U2 0
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0749-0704
EI 1557-8232
J9 CRIT CARE CLIN
JI Crit. Care Clin.
PD OCT
PY 2016
VL 32
IS 4
BP 567
EP +
DI 10.1016/j.ccc.2016.06.006
PG 11
WC Critical Care Medicine
SC General & Internal Medicine
GA EB9SS
UT WOS:000387738000010
PM 27600128
ER
PT J
AU Cancio, LC
Salinas, J
Kramer, GC
AF Cancio, Leopoldo C.
Salinas, Jose
Kramer, George C.
TI Protocolized Resuscitation of Burn Patients
SO CRITICAL CARE CLINICS
LA English
DT Article
DE Fluid resuscitation; Burns; Decision making-Computer-Assisted; Decision
support systems; Clinical
ID COMPUTER-SIMULATION BET; FLUID RESUSCITATION; THERMAL-INJURY; MILITARY
CASUALTIES; SYSTEM; TRAUMA; CREEP; SHOCK; VALIDATION; OUTCOMES
AB Fluid resuscitation of burn patients is commonly initiated using modified Brooke or Parkland formula. The fluid infusion rate is titrated up or down hourly to maintain adequate urine output and other endpoints. Over-resuscitation leads to morbid complications. Adherence to paper-based protocols, flow sheets, and clinical practice guidelines is associated with decreased fluid resuscitation volumes and complications. Computerized tools assist providers. Although completely autonomous closed-loop control of resuscitation has been demonstrated in animal models of burn shock, the major advantages of open-loop and decision-support systems are identifying trends, enhancing situational awareness, and encouraging burn team communication.
C1 [Cancio, Leopoldo C.; Salinas, Jose] US Army, Inst Surg Res, 3698 Chambers Pass, Jbsa Ft Sam Houston, TX 78234 USA.
[Kramer, George C.] Univ Texas Med Branch, Dept Anesthesiol, Galveston, TX 77555 USA.
RP Cancio, LC (reprint author), US Army, Inst Surg Res, 3698 Chambers Pass, Jbsa Ft Sam Houston, TX 78234 USA.
EM leopoldo.c.cancio.civ@mail.mil
FU Combat Casualty Care Research Program of the US Army Medical Research
and Materiel Command, Fort Detrick, MD
FX Funded by the Combat Casualty Care Research Program of the US Army
Medical Research and Materiel Command, Fort Detrick, MD.
NR 41
TC 0
Z9 0
U1 0
U2 0
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0749-0704
EI 1557-8232
J9 CRIT CARE CLIN
JI Crit. Care Clin.
PD OCT
PY 2016
VL 32
IS 4
BP 599
EP +
DI 10.1016/j.ccc.2016.06.008
PG 13
WC Critical Care Medicine
SC General & Internal Medicine
GA EB9SS
UT WOS:000387738000013
PM 27600131
ER
PT J
AU Shkuratov, SI
Baird, J
Antipov, VG
Talantsev, EF
Hackenberger, WS
Stults, AH
Altgilbers, LL
AF Shkuratov, Sergey I.
Baird, Jason
Antipov, Vladimir G.
Talantsev, Evgueni F.
Hackenberger, Wesley S.
Stults, Allen H.
Altgilbers, Larry L.
TI High Voltage Generation With Transversely Shock-Compressed
Ferroelectrics: Breakdown Field on Thickness Dependence
SO IEEE TRANSACTIONS ON PLASMA SCIENCE
LA English
DT Article; Proceedings Paper
CT 26th IEEE Symposium on Fusion Engineering (SOFE) colocated with the 20th
IEEE Pulsed Power Conference (PPC)
CY MAY 31-JUN 04, 2015
CL Austin, TX
SP IEEE
DE Electric breakdown; explosive pulsed power; ferroelectric generators
(FEGs)
ID LEAD-ZIRCONATE-TITANATE; X-CUT QUARTZ; DIELECTRIC-BREAKDOWN; WAVE
COMPRESSION; BARIUM-TITANATE; PZT 65-35; CERAMICS; DEPOLARIZATION;
STRENGTH; STRESS
AB The ability of ferroelectric materials to generate high voltage under shock compression is a fundamental physical effect that makes it possible to create miniature autonomous explosive-driven pulsed power systems. Shock-induced depolarization releases an electric charge at the electrodes of the ferroelectric element, and a high electric potential and a high electric field appear across the element. We performed systematic studies of the electric breakdown field, E-b(d), as a function of the ferroelectric element thickness, d, for Pb(Zr0.95Ti0.05)O-3 ( PZT 95/5) and Pb(Zr0.52Ti0.48)O-3 ( PZT 52/48) ceramics compressed by transverse shock waves ( shock front propagates perpendicular to the polarization vector) and established a relationship between these two values: E-b(d) = const . d(-xi). This law was found to be true in a wide range of ferroelectric element thicknesses from 1 to 50 mm. This result makes it possible to predict ferroelectric generator ( FEG) output voltages up to 500 kV and it forms the basis for the design of ultrahigh-voltage FEG systems.
C1 [Shkuratov, Sergey I.; Baird, Jason; Antipov, Vladimir G.] Loki Inc, Norwood, MO 65717 USA.
[Talantsev, Evgueni F.] Pulsed Power LLC, Lubbock, TX 79416 USA.
[Hackenberger, Wesley S.] TRS Technol Inc, State Coll, PA 16801 USA.
[Stults, Allen H.] US Army, Aviat & Missile Engn Ctr, Huntsville, AL 35807 USA.
[Altgilbers, Larry L.] US Army, Space & Missile Def Command, Army Strateg Command, Huntsville, AL 35807 USA.
RP Shkuratov, SI (reprint author), Loki Inc, Norwood, MO 65717 USA.
EM shkuratov@lokiconsult.com; jbaird@lokiconsult.com;
antipov@lokiconsult.com; evgeny.talantsev@vuw.ac.nz;
wes@trstechnologies.com; allen.h.stults.civ@mail.mil;
larry.l.altgilbers.civ@mail.mil
NR 38
TC 0
Z9 0
U1 4
U2 4
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 0093-3813
EI 1939-9375
J9 IEEE T PLASMA SCI
JI IEEE Trans. Plasma Sci.
PD OCT
PY 2016
VL 44
IS 10
BP 1919
EP 1927
DI 10.1109/TPS.2016.2553000
PN 1
PG 9
WC Physics, Fluids & Plasmas
SC Physics
GA EB3CP
UT WOS:000387239900010
ER
PT J
AU Carroll, MB
Newkirk, MR
Sumner, NS
AF Carroll, Matthew B.
Newkirk, Michelle R.
Sumner, Nathan S.
TI Necrotizing Autoimmune Myopathy A Unique Subset of Idiopathic
Inflammatory Myopathy
SO JCR-JOURNAL OF CLINICAL RHEUMATOLOGY
LA English
DT Article
DE idiopathic inflammatory myositis; myositis; necrotizing autoimmune
myopathy
ID CASE SERIES; DERMATOMYOSITIS; AUTOANTIBODIES; POLYMYOSITIS; CANCER
AB Necrotizing autoimmune myopathy (NAM) is a recently recognized entity within the spectrum of idiopathic inflammatory myopathies. Diagnosis critically rests on histopathologic demonstration of macrophage predominant myocyte destruction, with few to no lymphocytes. We report our experience with identifying and treating this subset of inflammatory myositis, highlighting the importance of muscle biopsy in diagnosis, association with statin use and malignancy, and challenges of therapy.
We present 3 cases that presented to 2 hospitals within our academic system in calendar year 2014 with acute/subacute onset of profound proximal muscle weakness and markedly elevated creatine kinase levels. All patients had been exposed to statins for varying periods. While each electromyogram (EMG) study showed changes with a diffuse inflammatory myopathy, it was not until muscle biopsy was performed when histopathologic features consistent with NAM solidified the diagnosis in all 3 cases. While high-dose glucocorticoids helped provide some degree of improvement in symptoms, none of our cases returned to their preillness baseline independent functioning. Additional immunosuppressive therapy was considered in each case but limited because of comorbidities.
These cases demonstrate the importance of pursuing muscle biopsy in all patients with proximal muscle weakness and markedly elevated creatine kinase levels. While symptoms appear consistent with polymyositis, only through muscle biopsy can the diagnosis of NAM be made. Statins have been implicated in NAM, acting through an antibody-dependent mechanism. Combination immunosuppressive therapy has been advocated, but our patient's comorbidities precluded safe use of medications beyond glucocorticoids.
C1 [Carroll, Matthew B.; Sumner, Nathan S.] Keesler Med Ctr, Ocean Springs, MS USA.
[Newkirk, Michelle R.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA.
RP Carroll, MB (reprint author), 301 Fisher Ave, Keesler AFB, MS 39534 USA.
EM matthew.carroll.1@us.af.mil
NR 16
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1076-1608
EI 1536-7355
J9 JCR-J CLIN RHEUMATOL
JI JCR-J. Clin. Rheumatol.
PD OCT
PY 2016
VL 22
IS 7
BP 376
EP 380
DI 10.1097/RHU.0000000000000427
PG 5
WC Rheumatology
SC Rheumatology
GA DZ2JV
UT WOS:000385669000007
PM 27660937
ER
PT J
AU Eickhoff, JC
Smith, JK
Landau, ME
Edison, JD
AF Eickhoff, Jeffrey C.
Smith, Jonathan K.
Landau, Mark E.
Edison, Jess D.
TI Iatrogenic Thenar Eminence Atrophy After Botox A Injection for Secondary
Raynaud Phenomenon
SO JCR-JOURNAL OF CLINICAL RHEUMATOLOGY
LA English
DT Letter
ID BOTULINUM-TOXIN-A; ONABOTULINUMTOXINA; MUSCLE
C1 [Eickhoff, Jeffrey C.; Edison, Jess D.] US Navy Med Corps, Bethesda, MD USA.
[Eickhoff, Jeffrey C.; Edison, Jess D.] Walter Reed Natl Mil Med Ctr, Rheumatol Serv, Bethesda, MD 20889 USA.
[Smith, Jonathan K.] US Army Med Corps, Ft Belvoir, VA USA.
[Smith, Jonathan K.] Ft Belvoir Community Hosp, Dept Neurol, Ft Belvoir, VA USA.
[Landau, Mark E.] Walter Reed Natl Mil Med Ctr, Dept Neurol, Bethesda, MD USA.
RP Eickhoff, JC (reprint author), US Navy Med Corps, Bethesda, MD USA.; Eickhoff, JC (reprint author), Walter Reed Natl Mil Med Ctr, Rheumatol Serv, Bethesda, MD 20889 USA.
EM Jeffrey.c.eickhoff.mil@mail.mil
NR 13
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1076-1608
EI 1536-7355
J9 JCR-J CLIN RHEUMATOL
JI JCR-J. Clin. Rheumatol.
PD OCT
PY 2016
VL 22
IS 7
BP 395
EP 396
PG 2
WC Rheumatology
SC Rheumatology
GA DZ2JV
UT WOS:000385669000015
ER
PT J
AU Gong, ZY
Pan, YL
Wang, CJ
AF Gong, Zhiyong
Pan, Yong-Le
Wang, Chuji
TI Optical configurations for photophoretic trap of single particles in air
SO REVIEW OF SCIENTIFIC INSTRUMENTS
LA English
DT Article
ID AEROSOL-PARTICLES; ABSORBING PARTICLES; DIELECTRIC PARTICLES;
RAMAN-SPECTRA; LASER-BEAM; FORCE; MANIPULATION; PRESSURE; MOTION; GAS
AB Since Ashkin's pioneering work in the 1970's, optical trapping (OT) and manipulation have become an indispensable tool in diverse research fields. Today, there are multiple optical trapping schemes in use. In this article, we explore six different optical trapping schemes based on the photophoretic force (PPF). Within these schemes we explore 21 variants differing in such details as laser source, power, beam shape, and focusing optics. We evaluate and rate the trapping quality and performance of the six trapping schemes in terms of four key aspects: simplicity, robustness, flexibility, and efficiency. One of the schemes is novel: we introduce a simple, high quality scheme using a confocal design in which one trapping beam is effectively converted to two counter-propagating beams. The versatility of this new trapping scheme is demonstrated via application of the scheme to cavity ringdown spectroscopy. We hope this exploration of the diversity of PPF trapping schemes will extend applications of OT by providing researchers with information to assist in the selection of specific optical trapping schemes from the first-of-its-kind list of 21 configurations presented herein. Published by AIP Publishing.
C1 [Gong, Zhiyong; Wang, Chuji] Mississippi State Univ, Dept Phys & Astron, Starkville, MS 39759 USA.
[Pan, Yong-Le] US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
RP Wang, CJ (reprint author), Mississippi State Univ, Dept Phys & Astron, Starkville, MS 39759 USA.
EM cw175@msstate.edu
NR 39
TC 0
Z9 0
U1 4
U2 4
PU AMER INST PHYSICS
PI MELVILLE
PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA
SN 0034-6748
EI 1089-7623
J9 REV SCI INSTRUM
JI Rev. Sci. Instrum.
PD OCT
PY 2016
VL 87
IS 10
AR 103104
DI 10.1063/1.4963842
PG 10
WC Instruments & Instrumentation; Physics, Applied
SC Instruments & Instrumentation; Physics
GA EB8SS
UT WOS:000387661900011
ER
PT J
AU Lee, N
Horstemeyer, MF
Prabhu, R
Liao, J
Rhee, H
Hammi, Y
Moser, RD
Williams, LN
AF Lee, Nayeon
Horstemeyer, M. F.
Prabhu, R.
Liao, Jun
Rhee, Hongjoo
Hammi, Youssef
Moser, Robert D.
Williams, Lakiesha N.
TI The geometric effects of a woodpecker's hyoid apparatus for stress wave
mitigation
SO BIOINSPIRATION & BIOMIMETICS
LA English
DT Article
DE woodpecker; hyoid; impact mitigation; finite element analysis; bio
inspiration; biomechanics
ID MECHANICAL-PROPERTIES; BRAIN-INJURY; MODULUS; BONE
AB In this study a woodpecker's hyoid apparatus was characterized to determine its impact mitigation mechanism using finite element (FE) analysis. The woodpecker's hyoid apparatus, comprising bone and muscle, has a unique geometry compared to those of other birds. The hyoid starts at the beak tip, surrounds the woodpecker's skull, and ends at the upper beak/front head intersection while being surrounded by muscle along the whole length. A FE model of the hyoid apparatus was created based on the geometry, microstructure, and mechanical properties garnered from our experimental measurements. Wecompared the impact mitigation capabilities of the hyoid apparatus with an idealized straight cylinder and a tapered cylinder. The results showed that the hyoid geometry mitigated a greater amount of pressure and impulse compared to the straight or tapered cylinders. The initially applied longitudinal wave lost its strength from attenuation and conversion to transverse shear waves. This is due to the spiral curvature and tapered geometry, which induced lateral displacement in the hyoid bone. The lateral displacement of the bony hyoid induced strains on the adjacent muscle, where the energy dissipated due to the muscle's viscoelasticity. Quantitatively, as the stress wave traveled from the anterior to the posterior end of the hyoid apparatus, its pressure decreased 75% and the associated impulse decreased 84%. The analysis of the woodpecker's hyoid apparatus provides a novel perspective on impact mitigation mediated by a spiral-shaped structure and viscoelastic biocomposite.
C1 [Lee, Nayeon; Prabhu, R.; Liao, Jun; Williams, Lakiesha N.] Mississippi State Univ, Dept Agr & Biol Engn, Mississippi State, MS 39762 USA.
[Lee, Nayeon; Horstemeyer, M. F.; Prabhu, R.; Rhee, Hongjoo; Hammi, Youssef; Williams, Lakiesha N.] Mississippi State Univ, Ctr Adv Vehicular Syst, Mississippi State, MS 39762 USA.
[Horstemeyer, M. F.] Mississippi State Univ, Dept Mech Engn, Mississippi State, MS 39762 USA.
[Moser, Robert D.] US Army, Engn Res & Dev Ctr, Geotech & Struct Lab, Vicksburg, MS 39180 USA.
[Williams, Lakiesha N.] Mississippi State Univ, Biol Engn, POB 9632, Mississippi State, MS 39762 USA.
RP Williams, LN (reprint author), Mississippi State Univ, Dept Agr & Biol Engn, Mississippi State, MS 39762 USA.; Williams, LN (reprint author), Mississippi State Univ, Ctr Adv Vehicular Syst, Mississippi State, MS 39762 USA.; Williams, LN (reprint author), Mississippi State Univ, Biol Engn, POB 9632, Mississippi State, MS 39762 USA.
EM lwilliams@abe.msstate.edu
FU Department of Agricultural and Biological Engineering at Mississippi
State University; Center for Advanced Vehicular Systems (CAVS) at
Mississippi State University; US Government [W15QKN-13-90001]
FX The authors would like to acknowledge the financial support from the
Department of Agricultural and Biological Engineering, and the Center
for Advanced Vehicular Systems (CAVS) at Mississippi State University.;
This effort was sponsored by the US Government under Other Transaction
number W15QKN-13-90001 between the Consortium for Energy, Environment
and Demilitarization, and the Government. The US Government is
authorized to reproduce and distribute reprints for Governmental
purposes notwithstanding any copyright notation thereon.
NR 22
TC 0
Z9 0
U1 8
U2 8
PU IOP PUBLISHING LTD
PI BRISTOL
PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
SN 1748-3182
EI 1748-3190
J9 BIOINSPIR BIOMIM
JI Bioinspir. Biomim.
PD OCT
PY 2016
VL 11
IS 6
AR 066004
DI 10.1088/1748-3190/11/6/066004
PG 9
WC Engineering, Multidisciplinary; Materials Science, Biomaterials;
Robotics
SC Engineering; Materials Science; Robotics
GA EB2AA
UT WOS:000387157300002
PM 27780157
ER
PT J
AU Cardile, AP
Downey, LG
Wiseman, PD
Warren, TK
Bavari, S
AF Cardile, Anthony P.
Downey, Lydia G.
Wiseman, Perry D.
Warren, Travis K.
Bavari, Sina
TI Antiviral therapeutics for the treatment of Ebola virus infection
SO CURRENT OPINION IN PHARMACOLOGY
LA English
DT Article
ID NONHUMAN-PRIMATES; RNA INTERFERENCE; FILOVIRUS INFECTIONS; CONVALESCENT
PLASMA; HEMORRHAGIC-FEVER; T-705 FAVIPIRAVIR; MOUSE MODEL; DISEASE;
EFFICACY; ANTIBODY
AB There have been significant developments in Ebola virus therapeutics. While the efficacy of several products was evaluated in the recent West Africa outbreak, a licensed treatment for EBOV disease remains elusive. Factors that negatively impacted the execution of clinical trials included an overall lack of world readiness to conduct clinical trials in an outbreak setting, ethical concerns limiting implementation of the randomized controlled trials in an outbreak setting, and a decline in case numbers by the time resources were mobilized to conduct clinical trials. We summarize relevant therapeutics that underwent clinical trials during the West Africa outbreak and highlight promising candidates under advanced development.
C1 [Cardile, Anthony P.; Downey, Lydia G.; Wiseman, Perry D.] US Army Med Res Inst Infect Dis, Div Med, 1425 Porter St, Frederick, MD 21702 USA.
[Warren, Travis K.] US Army Med Res Inst Infect Dis, Translat Med Div, 1425 Porter St, Frederick, MD 21702 USA.
[Bavari, Sina] US Army Med Res Inst Infect Dis, 1425 Porter St, Frederick, MD 21702 USA.
RP Cardile, AP (reprint author), US Army Med Res Inst Infect Dis, Div Med, 1425 Porter St, Frederick, MD 21702 USA.
EM anthony.p.cardile.mil@mail.mil
FU U.S. Department of Defense Joint Project Manager Medical Countermeasure
Systems (JPM-MCS); U.S. Defense Threat Reduction Agency (DTRA) Joint
Science and Technology Office for Chemical and Biological Defense
(JSTO-CBD)
FX The authors would like to acknowledge funding from U.S. Department of
Defense Joint Project Manager Medical Countermeasure Systems (JPM-MCS)
and the U.S. Defense Threat Reduction Agency (DTRA) Joint Science and
Technology Office for Chemical and Biological Defense (JSTO-CBD).
NR 34
TC 1
Z9 1
U1 2
U2 2
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1471-4892
EI 1471-4973
J9 CURR OPIN PHARMACOL
JI Curr. Opin. Pharmacol.
PD OCT
PY 2016
VL 30
BP 138
EP 143
DI 10.1016/j.coph.2016.08.016
PG 6
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA EA8BV
UT WOS:000386861200019
PM 27639220
ER
PT J
AU van Helmond, N
Johnson, BD
Curry, TB
Cap, AP
Convertino, VA
Joyner, MJ
AF van Helmond, Noud
Johnson, Blair D.
Curry, Timothy B.
Cap, Andrew P.
Convertino, Victor A.
Joyner, Michael J.
TI White blood cell concentrations during lower body negative pressure and
blood loss in humans
SO EXPERIMENTAL PHYSIOLOGY
LA English
DT Article
ID CENTRAL VENOUS-PRESSURE; COMBAT CASUALTY CARE; HEMORRHAGE;
LYMPHOCYTOSIS; RESPONSES; PLASMA; VOLUME; MODEL; KINETICS; TRAUMA
AB Hypovolaemia has been associated with an immune response that might be secondary to sympathoexcitation. We tested the hypothesis that simulated hypovolaemia using lower body negative pressure (LBNP) and real hypovolaemia induced via experimental blood loss (BL) cause similar increases in the white blood cell concentration ([WBC]). We measured [WBC] and catecholamine concentrations in 12 men who underwent an LBNP and a BL protocol in a randomized order. We compared 45 mmHg of LBNP with 1000 ml of BL; therefore, [WBC] and catecholamine concentrations were plotted against central venous pressure to obtain stimulus-response relationships using the linear regression line slopes for both protocols. Mean regression line slopes were similar for total [WBC] (LBNP 183 +/- 4 mu l(-1) mmHg(-1) versus BL 155 +/- 109 mu l(-1) mmHg(-1), P = 0.15), neutrophils (LBNP 110 +/- 2 mu l(-1) mmHg(-1) versus BL 96 +/- 72 mu l(-1) mmHg(-1), P= 0.15) and lymphocytes (LBNP 65 +/- 21 mu l(-1) mmHg(-1) versus BL 59 +/- 38 mu l(-1) mmHg(-1), P= 0.90). Mean regression line slopes for adrenalinewere similar (LBNP 15 +/- 5 pg ml(-1) mmHg(-1) versus BL 16 +/- 4 pg l(-1) mmHg(-1), P= 0.84) and were steeper during LBNP for noradrenaline (LBNP 28 +/- 6 pg ml(-1) mmHg(-1) versus BL 9 +/- 6 pg ml(-1) mmHg(-1), P = 0.01). These data indicate that central hypovolaemia elicits a relative leucocytosis with a predominantly neutrophil-based response. Additionally, our results indicate that LBNPmodels the stimulus-response relationship between central venous pressure and[WBC] observed during BL.
C1 [van Helmond, Noud; Johnson, Blair D.; Curry, Timothy B.; Joyner, Michael J.] Mayo Clin, Dept Anesthesiol, Rochester, MN USA.
[Johnson, Blair D.] SUNY Buffalo, Ctr Res & Educ Special Environm, Dept Exercise & Nutr Sci, Buffalo, NY USA.
[Cap, Andrew P.; Convertino, Victor A.] US Army Inst Surg Res, Ft Sam Houston, TX USA.
RP Johnson, BD (reprint author), 208A Kimball Tower, Buffalo, NY 14214 USA.
EM blairjoh@buffalo.edu
FU US Army MRMC Combat Casualty Care Research Program [W81XWH-11-1-0823];
American Heart Association Midwest Affiliate Grant [13POST-14380027];
Dutch Heart Foundation [2012SB013]
FX Support for this study was provided by US Army MRMC Combat Casualty Care
Research Program Grant W81XWH-11-1-0823 to M.J.J., American Heart
Association Midwest Affiliate Grant 13POST-14380027 to B.D.J. and Dutch
Heart Foundation E. Dekker Stipend 2012SB013 to N.v.H.
NR 38
TC 0
Z9 0
U1 1
U2 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0958-0670
EI 1469-445X
J9 EXP PHYSIOL
JI Exp. Physiol.
PD OCT
PY 2016
VL 101
IS 10
BP 1265
EP 1275
DI 10.1113/EP085952
PG 11
WC Physiology
SC Physiology
GA EB1BI
UT WOS:000387080900003
PM 27520090
ER
PT J
AU Miller, E
Kaufman, K
Kingsbury, T
Wolf, E
Wilken, J
Wyatt, M
AF Miller, Emily
Kaufman, Kenton
Kingsbury, Trevor
Wolf, Erik
Wilken, Jason
Wyatt, Marilynn
TI Mechanical testing for three-dimensional motion analysis reliability
SO GAIT & POSTURE
LA English
DT Article
DE Gait; Motion analysis; Reliability; Motion capture system validation
ID HIP-JOINT CENTER; CENTER LOCATION; PREDICTION; WALKING; KINEMATICS;
ACCURACY; ADULTS
AB The purpose of this study was to use simple mechanical tests to evaluate the reliability of three dimensional motion analysis systems and biomechanical models. Three different tests were conducted at four motion analysis laboratories where clinical care and research studies are routinely performed. The laboratories had different motion capture systems, different types and number of cameras, different types and numbers of force plates and different biomechanical models. These mechanical tests evaluated the accuracy of the motion capture system, the integration of the force plate and the motion capture system, and the strength of the biomechanical model used to calculate rotational kinematics. Results of motion capture system accuracy tests showed that, for all labs, the error, between the measured and calculated distances between markers was less than 2 mm and 1 for marker separations which ranged from 24 mm to 500 mm. Results from the force plate integration tests demonstrated errors in center of pressure calculation of less than 4 mm across all labs, despite varied force plate and motion system configurations. Finally, errors across labs for single joint rotations and for combined rotations at the hip and knee were less than 2 at the hip and less than 10 at the knee. These results demonstrate that system accuracy and reliability can be obtained allowing the collection of comparable data across different motion analysis laboratories with varying configurations and equipment. This testing is particularly important when multi-center studies are planned in order to assure data consistency across labs. (C) 2016 Elsevier B.V. All rights reserved.
C1 [Miller, Emily] Mayo Clin, Mot Anal Lab, Rochester, MN USA.
[Kaufman, Kenton] Mayo Clin, Biomech Mot Anal Lab, Charlton North L-110L,200 First St SW, Rochester, MN USA.
[Kingsbury, Trevor; Wyatt, Marilynn] Naval Med Ctr San Diego, San Diego, CA USA.
[Wolf, Erik] Walter Reed Natl Mil Med Ctr, Bethesda, MD USA.
[Wilken, Jason] JBSA, Brooke Army Med Ctr, Ctr Intrepid, Ft Sam Houston, TX USA.
RP Kaufman, K (reprint author), Biomech Mot Anal Lab, Charlton North L-110L,200 First St SW, Rochester, MN 55905 USA.
EM kaufman.kenton@mayo.edu
OI Kaufman, Kenton/0000-0002-7311-3781
FU DOD [731743-1]; DOD Defense Health Programs/Center for Rehabilitative
Sciences Research [HU0001-11-1-0004]
FX Funding was provided by DOD 731743-1, DOD Defense Health Programs/Center
for Rehabilitative Sciences Research, Grant # HU0001-11-1-0004.
NR 10
TC 0
Z9 0
U1 3
U2 3
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 0966-6362
EI 1879-2219
J9 GAIT POSTURE
JI Gait Posture
PD OCT
PY 2016
VL 50
BP 116
EP 119
DI 10.1016/j.gaitpost.2016.08.017
PG 4
WC Neurosciences; Orthopedics; Sport Sciences
SC Neurosciences & Neurology; Orthopedics; Sport Sciences
GA EB2LC
UT WOS:000387192600019
PM 27592076
ER
PT J
AU Reuben, A
Moffitt, TE
Caspi, A
Belsky, DW
Harrington, H
Schroeder, F
Hogan, S
Ramrakha, S
Poulton, R
Danese, A
AF Reuben, Aaron
Moffitt, Terrie E.
Caspi, Avshalom
Belsky, Daniel W.
Harrington, Honalee
Schroeder, Felix
Hogan, Sean
Ramrakha, Sandhya
Poulton, Richie
Danese, Andrea
TI Lest we forget: comparing retrospective and prospective assessments of
adverse childhood experiences in the prediction of adult health
SO JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
LA English
DT Article
DE Adverse childhood experiences; physical health; mental health; cognitive
health; epidemiology
ID PSYCHIATRIC-DISORDERS; MENTAL-DISORDERS; AUTOBIOGRAPHICAL MEMORY; ABUSE;
ASSOCIATION; DEPRESSION; ATTENTION; IMPACT; PSYCHOPATHOLOGY;
VICTIMIZATION
AB Background: Adverse childhood experiences (ACEs; e.g. abuse, neglect, and parental loss) have been associated with increased risk for later-life disease and dysfunction using adults' retrospective self-reports of ACEs. Research should test whether associations between ACEs and health outcomes are the same for prospective and retrospective ACE measures. Methods: We estimated agreement between ACEs prospectively recorded throughout childhood (by Study staff at Study member ages 3, 5, 7, 9, 11, 13, and 15) and retrospectively recalled in adulthood (by Study members when they reached age 38), in the population-representative Dunedin cohort (N = 1,037). We related both retrospective and prospective ACE measures to physical, mental, cognitive, and social health at midlife measured through both objective (e.g. biomarkers and neuropsychological tests) and subjective (e.g. self-reported) means. Results: Dunedin and U.S. Centers for Disease Control ACE distributions were similar. Retrospective and prospective measures of adversity showed moderate agreement (r = .47, p < .001; weighted Kappa = .31, 95% CI: .27-.35). Both associated with all midlife outcomes. As compared to prospective ACEs, retrospective ACEs showed stronger associations with life outcomes that were subjectively assessed, and weaker associations with life outcomes that were objectively assessed. Recalled ACEs and poor subjective outcomes were correlated regardless of whether prospectively recorded ACEs were evident. Individuals who recalled more ACEs than had been prospectively recorded were more neurotic than average, and individuals who recalled fewer ACEs than recorded were more agreeable. Conclusions: Prospective ACE records confirm associations between childhood adversity and negative life outcomes found previously using retrospective ACE reports. However, more agreeable and neurotic dispositions may, respectively, bias retrospective ACE measures toward underestimating the impact of adversity on objectively measured life outcomes and overestimating the impact of adversity on self-reported outcomes. Associations between personality factors and the propensity to recall adversity were extremely modest and warrant further investigation. Risk predictions based on retrospective ACE reports should utilize objective outcome measures. Where objective outcome measurements are difficult to obtain, correction factors may be warranted.
C1 [Reuben, Aaron; Moffitt, Terrie E.; Caspi, Avshalom; Harrington, Honalee] Duke Univ, Dept Psychol & Neurosci, Durham, NC 27708 USA.
[Moffitt, Terrie E.; Caspi, Avshalom] Duke Univ, Ctr Genom & Computat Biol, Durham, NC USA.
[Moffitt, Terrie E.; Caspi, Avshalom] Duke Univ, Dept Psychiat & Behav Sci, Durham, NC USA.
[Moffitt, Terrie E.; Caspi, Avshalom; Danese, Andrea] Kings Coll London, Inst Psychiat Psychol & Neurosci, Social Genet & Dev Psychiat Ctr, London, England.
[Belsky, Daniel W.] Duke Univ, Social Sci Res Inst, Durham, NC USA.
[Belsky, Daniel W.] Duke Univ, Sch Med, Dept Med, Durham, NC 27706 USA.
[Schroeder, Felix] US Army, Ft Bragg, NC USA.
[Hogan, Sean; Ramrakha, Sandhya; Poulton, Richie] Univ Otago, Dunedin Multidisciplinary Hlth & Dev Res Unit, Dept Psychol, Dunedin, New Zealand.
[Danese, Andrea] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Child & Adolescent Psychiat, London, England.
RP Reuben, A (reprint author), Duke Univ, Dept Psychol & Neurosci, Durham, NC 27708 USA.
EM aaron.reuben@duke.edu
RI Moffitt, Terrie/D-5295-2011
OI Moffitt, Terrie/0000-0002-8589-6760
FU New Zealand Health Research Council; New Zealand Ministry of Business,
Innovation and Employment (MBIE); US-National Institute of Aging
[R01AG032282, R01AG049789, R01AG048895]; U.K. Medical Research Council
[MR/ K00381X]; Economic and Social Research Council [ES/M010309/1];
Jacobs Foundation
FX The authors thank the Dunedin Study members, their parents, teachers,
and peer informants, Unit research staff, and Study founder Phil Silva.
The Dunedin Multidisciplinary Health and Development Research Unit is
supported by the New Zealand Health Research Council and New Zealand
Ministry of Business, Innovation and Employment (MBIE). This research
received support from the US-National Institute of Aging (grants
R01AG032282, R01AG049789, and R01AG048895), the U.K. Medical Research
Council (grant MR/ K00381X), the Economic and Social Research Council
(grant ES/M010309/1), and the Jacobs Foundation. The authors have
declared that they have no competing or potential conflicts of interest
in relation to this article.
NR 57
TC 0
Z9 0
U1 20
U2 20
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-9630
EI 1469-7610
J9 J CHILD PSYCHOL PSYC
JI J. Child Psychol. Psychiatry
PD OCT
PY 2016
VL 57
IS 10
BP 1103
EP 1112
DI 10.1111/jcpp.12621
PG 10
WC Psychology, Developmental; Psychiatry; Psychology
SC Psychology; Psychiatry
GA EB1PE
UT WOS:000387125000002
PM 27647050
ER
PT J
AU DeVries, M
Pittari, J
Subhash, G
Mills, K
Haines, C
Zheng, JQ
AF DeVries, Matthew
Pittari, John, III
Subhash, Ghatu
Mills, Kendall
Haines, Chris
Zheng, James Q.
TI Rate-Dependent Mechanical Behavior and Amorphization of
Ultrafine-Grained Boron Carbide
SO JOURNAL OF THE AMERICAN CERAMIC SOCIETY
LA English
DT Article
DE boron carbide; amorphization; hardness; Raman spectroscopy
ID DYNAMIC INDENTATION RESPONSE; HOPKINSON PRESSURE BAR;
RAMAN-SPECTROSCOPY; CERAMICS; NANOMATERIALS; TOUGHNESS; FRACTURE;
HARDNESS; B4C
AB An investigation into mechanical properties and amorphization behavior of ultrafine-grained (0.3 mu m) boron carbide (B4C) is conducted and compared to a baseline coarse-grained (10 mu m) boron carbide. Static and dynamic uniaxial compressive strength, and static and dynamic Vickers indentation hardness were determined, and Raman spectroscopy was then conducted on indented regions to quantify and compare the intensity of amorphization. In relation to coarse-grained B4C the ultrafine-grained material exhibited, on average, a 33% higher static compressive strength, 20% higher dynamic compressive strength, 10% higher static Vickers hardness, and 23% higher dynamic Vickers hardness. In addition, there was an 18% reduction in indentation-induced radial crack length in ultrafine-grained B4C, which corresponded to an increase in estimated fracture toughness. Although traditional coarse-grained B4C exhibits an 8.6% decrease in hardness from the static to dynamic regimes, ultrafine-grained B4C showed only negligible change under similar conditions, suggesting a reduced propensity for amorphization. Raman spectroscopic analysis confirmed this result by revealing significantly lower amorphization intensity in ultrafine-B4C compared to coarse-grained B4C. These results may have significant positive implications in the implementation of ultrafine-grained boron carbide as a material for improved performance in impact and other high-pressure applications.
C1 [DeVries, Matthew; Pittari, John, III; Subhash, Ghatu] Univ Florida, Dept Mech & Aerosp Engn, Gainesville, FL 32611 USA.
[Mills, Kendall; Haines, Chris] Picatinny Arsenal, Wharton, NJ 07806 USA.
[Zheng, James Q.] US Army, Program Execut Off Soldier, Ft Belvoir, VA 22060 USA.
RP Subhash, G (reprint author), Univ Florida, Dept Mech & Aerosp Engn, Gainesville, FL 32611 USA.
EM subhash@ufl.edu
FU Army Research Office [W911NF-14-1-0230]
FX The support from Picatinny Arsenal is gratefully acknowledged for supply
of the ultrafine-grained B4C, as is the assistance from
Andres Trucco for his help in SEM imaging. This research was partially
supported by a grant from Army Research Office award no.
W911NF-14-1-0230.
NR 41
TC 0
Z9 0
U1 7
U2 7
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0002-7820
EI 1551-2916
J9 J AM CERAM SOC
JI J. Am. Ceram. Soc.
PD OCT
PY 2016
VL 99
IS 10
BP 3398
EP 3405
DI 10.1111/jace.14324
PG 8
WC Materials Science, Ceramics
SC Materials Science
GA EB2WL
UT WOS:000387223200033
ER
PT J
AU Akapirat, S
Teeratakulpisarn, N
Nonenoy, S
Wongkanya, R
Madnote, S
Puangkaew, J
Rittiroongrad, S
Trichavaroj, R
Hongchookiat, P
Pankam, T
Kanaprach, R
Riyaten, P
Kerr, SJ
Ananworanich, J
Michael, NL
Phanuphak, P
Phanuphak, N
Connell, RJO
van Griensven, F
Karasavvas, N
AF Akapirat, Siriwat
Teeratakulpisarn, Nipat
Nonenoy, Siriporn
Wongkanya, Rapeeporn
Madnote, Sirinan
Puangkaew, Jiraporn
Rittiroongrad, Surawach
Trichavaroj, Rapee
Hongchookiat, Piranun
Pankam, Tippawan
Kanaprach, Ratchapong
Riyaten, Prakit
Kerr, Stephen J.
Ananworanich, Jintanat
Michael, Nelson L.
Phanuphak, Praphan
Phanuphak, Nittaya
Connell, Robert J. O.
van Griensven, Frits
Karasavvas, Nicos
TI Antibody Characterization in Neovaginal and Rectal Secretions of
Transgender Women
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Conference on HIV Research for Prevention (HIV R4P)
CY OCT 17-20, 2016
CL Chicago, IL
C1 [Akapirat, Siriwat; Madnote, Sirinan; Puangkaew, Jiraporn; Rittiroongrad, Surawach; Trichavaroj, Rapee; Connell, Robert J. O.; Karasavvas, Nicos] Armed Forces Res Inst Med Sci, Bangkok, Thailand.
[Teeratakulpisarn, Nipat; Nonenoy, Siriporn; Wongkanya, Rapeeporn; Hongchookiat, Piranun; Pankam, Tippawan; Phanuphak, Praphan; Phanuphak, Nittaya; van Griensven, Frits] Thai Red Cross AIDS Res Ctr, Prevent Dept, Bangkok, Thailand.
[Kanaprach, Ratchapong; Kerr, Stephen J.; Phanuphak, Praphan] Thai Red Cross AIDS Res Ctr, SEARCH, Bangkok, Thailand.
[Riyaten, Prakit; Kerr, Stephen J.; Phanuphak, Praphan] Thai Red Cross AIDS Res Ctr, HIV NAT, Bangkok, Thailand.
[Ananworanich, Jintanat; Michael, Nelson L.] Walter Reed Army Inst Res, US Mil HIV Res Program, Washington, DC USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT
PY 2016
VL 32
SU 1
MA P18.33
BP 321
EP 321
PG 1
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA EA6YH
UT WOS:000386774600595
ER
PT J
AU Akapirat, S
Madnote, S
Pitisuttithum, P
Nitayaphan, S
Chariyalertsak, S
Rittiroongrad, S
Puangkaew, J
Chantakulkij, S
Phogat, S
Sinangil, F
Excler, JL
Robb, ML
Michael, NL
Kim, JH
Vasan, S
Connell, RJO
Karasavvas, N
AF Akapirat, Siriwat
Madnote, Sirinan
Pitisuttithum, Punnee
Nitayaphan, Sorachai
Chariyalertsak, Suwat
Rittiroongrad, Surawach
Puangkaew, Jiraporn
Chantakulkij, Somsak
Phogat, Sanjay
Sinangil, Faruk
Excler, Jean-Louis
Robb, Merlin L.
Michael, Nelson L.
Kim, Jerome H.
Vasan, Sandhya
Connell, Robert J. O.
Karasavvas, Nicos
CA RV306 Study Grp
TI Characterization of Antibody Responses in Anogenital Secretions of
ALVAC-HIV and AIDSVAXB/E Prime-boost Vaccinations with Varying Late
Boosts (RV306)
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Conference on HIV Research for Prevention (HIV R4P)
CY OCT 17-20, 2016
CL Chicago, IL
C1 [Akapirat, Siriwat; Madnote, Sirinan; Nitayaphan, Sorachai; Rittiroongrad, Surawach; Puangkaew, Jiraporn; Chantakulkij, Somsak; Vasan, Sandhya; Connell, Robert J. O.; Karasavvas, Nicos] Armed Forces Res Inst Med Sci, Bangkok, Thailand.
[Pitisuttithum, Punnee] Mahidol Univ, Fac Trop Med, Bangkok, Thailand.
[Chariyalertsak, Suwat] Chiang Mai Univ, Res Inst Hlth Sci, Chiang Mai, Thailand.
[Phogat, Sanjay] Sanofi Pasteur, Swiftwater, PA USA.
[Sinangil, Faruk] Global Solut Infect Dis, San Francisco, CA USA.
[Excler, Jean-Louis; Kim, Jerome H.] Int Vaccine Inst, Seoul, South Korea.
[Robb, Merlin L.; Michael, Nelson L.; Vasan, Sandhya] Walter Reed Army Inst Res, US Mil HIV Res Program, Washington, DC USA.
[Robb, Merlin L.; Vasan, Sandhya] Henry M Jackson Fdn Adv Mil Med, Washington, DC USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT
PY 2016
VL 32
SU 1
MA P18.34
BP 321
EP 321
PG 1
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA EA6YH
UT WOS:000386774600596
ER
PT J
AU Li, P
Moon, SY
Guelta, MA
Lin, L
Gomez-Gualdron, DA
Snurr, RQ
Harvey, SP
Hupp, JT
Farha, OK
AF Li, Peng
Moon, Su-Young
Guelta, Mark A.
Lin, Lu
Gomez-Gualdron, Diego A.
Snurr, Randall Q.
Harvey, Steven P.
Hupp, Joseph T.
Farha, Omar K.
TI Nanosizing a Metal-Organic Framework Enzyme Carrier for Accelerating
Nerve Agent Hydrolysis
SO ACS NANO
LA English
DT Article
DE metal-organic framework; enzyme immobilization; nerve agent catalysis;
nanocarrier
ID ORGANOPHOSPHORUS ACID ANHYDROLASE; ULTRAHIGH SURFACE-AREA;
IMMOBILIZATION; DESIGN; SIZE; ENCAPSULATION; MOFS; RECOGNITION;
SEPARATIONS; SELECTIVITY
AB We report the synthesis and characterization of a water-stable zirconium metal organic framework (MOF), NU-1003, featuring the largest mesoporous aperture known for a zirconium MOF. This material has been used to immobilize the nerve agent hydrolyzing enzyme, organophosphorus acid anhydrolase (OPAA). The catalytic efficiency of immobilized OPAA in nanosized NU 1003 is significantly increased compared to that of OPAA immobilized in microsized NU-1003 and even exceeds that of the free OPAA enzyme. This paper highlights a method for rapid and highly efficient hydrolysis of nerve agents using nanosized enzyme carriers.
C1 [Li, Peng; Moon, Su-Young; Lin, Lu; Hupp, Joseph T.; Farha, Omar K.] Northwestern Univ, Dept Chem, 2145 Sheridan Rd, Evanston, IL 60208 USA.
[Gomez-Gualdron, Diego A.; Snurr, Randall Q.] Northwestern Univ, Dept Chem & Biol Engn, 2145 Sheridan Rd, Evanston, IL 60208 USA.
[Guelta, Mark A.; Harvey, Steven P.] US Army Edgewood Chem Biol Ctr, RDCB DRC C, 5183 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA.
[Lin, Lu] Dalian Univ Technol, Sch Chem Engn, State Key Lab Fine Chem, Dalian 116024, Peoples R China.
[Farha, Omar K.] King Abdulaziz Univ, Fac Sci, Dept Chem, Jeddah 21589, Saudi Arabia.
RP Farha, OK (reprint author), Northwestern Univ, Dept Chem, 2145 Sheridan Rd, Evanston, IL 60208 USA.; Farha, OK (reprint author), King Abdulaziz Univ, Fac Sci, Dept Chem, Jeddah 21589, Saudi Arabia.
EM o-farha@northwestern.edu
RI Faculty of, Sciences, KAU/E-7305-2017
FU DTRA [HDTRA-1-14-1-0014]; MRSEC program of the National Science
Foundation at the Materials Research Center of Northwestern University
[DMR-1121262]; NU Office for Research; MRSEC program at the Materials
Research Center [NSF DMR-1121262]; International Institute for
Nanotechnology (IIN); State of Illinois, through the IIN
FX O.K.F., J.T.H., and R.Q.S. gratefully acknowledge DTRA for financial
support (Grant No. HDTRA-1-14-1-0014). This work made use of the J.B.
Cohen X-ray Diffraction Facility supported by the MRSEC program of the
National Science Foundation (DMR-1121262) at the Materials Research
Center of Northwestern University. Confocal microscopy imaging work was
done at the Northwestern University Biological Imaging Facility
generously supported by the NU Office for Research. This work also made
use of the EPIC facility (NUANCE Center, Northwestern University), which
has received support from the MRSEC program (NSF DMR-1121262) at the
Materials Research Center; the International Institute for
Nanotechnology (IIN); and the State of Illinois, through the IIN.
NR 68
TC 0
Z9 1
U1 53
U2 53
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1936-0851
EI 1936-086X
J9 ACS NANO
JI ACS Nano
PD OCT
PY 2016
VL 10
IS 10
BP 9174
EP 9182
DI 10.1021/acsnano.6b04996
PG 9
WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience &
Nanotechnology; Materials Science, Multidisciplinary
SC Chemistry; Science & Technology - Other Topics; Materials Science
GA EA2LK
UT WOS:000386423600017
ER
PT J
AU Kijak, G
AF Kijak, Gustavo
CA RV 217 Study Team
TI Early Events in HIV-1 Infection: New Insight from the RV217 Early
Capture Acute Infection Cohort
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Conference on HIV Research for Prevention (HIV R4P)
CY OCT 17-20, 2016
CL Chicago, IL
C1 [Kijak, Gustavo] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT
PY 2016
VL 32
SU 1
MA RT01.02
BP 26
EP 26
PG 1
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA EA6YH
UT WOS:000386774600029
ER
PT J
AU Doria-Rose, NA
Krebs, S
Law, W
Gift, S
Chenine, A
Rolland, M
Moody, MA
Jarosinski, M
Georgiev, I
Chuang, GY
Asokan, M
Bailer, RT
Cale, EM
Louder, M
Kwong, PD
Polonis, V
Haynes, B
Tovanabutra, S
Robb, M
Mascola, JR
AF Doria-Rose, Nicole A.
Krebs, Shelly
Law, Wiliam
Gift, Syna
Chenine, Agnes
Rolland, Morgane
Moody, M. Anthony
Jarosinski, Marissa
Georgiev, Ivelin
Chuang, Gwo-Yu
Asokan, Mangaiarkarasi
Bailer, Robert T.
Cale, Evan M.
Louder, Mark
Kwong, Peter D.
Polonis, Victoria
Haynes, Barton
Tovanabutra, Sodsai
Robb, Merlin
Mascola, John R.
TI HIV-1 MPER-directed Broadly Neutralizing Antibodies from an
Acute-infection Cohort RV217 Subject
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Conference on HIV Research for Prevention (HIV R4P)
CY OCT 17-20, 2016
CL Chicago, IL
C1 [Doria-Rose, Nicole A.; Law, Wiliam; Jarosinski, Marissa; Georgiev, Ivelin; Chuang, Gwo-Yu; Asokan, Mangaiarkarasi; Bailer, Robert T.; Cale, Evan M.; Louder, Mark; Kwong, Peter D.; Mascola, John R.] NIAID, Vaccine Res Ctr, NIH, Rockville, MD USA.
[Krebs, Shelly; Gift, Syna; Chenine, Agnes; Rolland, Morgane; Polonis, Victoria; Tovanabutra, Sodsai; Robb, Merlin] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA.
[Krebs, Shelly; Gift, Syna; Chenine, Agnes; Rolland, Morgane; Polonis, Victoria; Tovanabutra, Sodsai; Robb, Merlin] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA.
[Moody, M. Anthony; Haynes, Barton] Duke Human Vaccine Inst, Durham, NC USA.
[Georgiev, Ivelin] Vanderbilt Univ, Nashville, TN USA.
NR 0
TC 0
Z9 0
U1 2
U2 2
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT
PY 2016
VL 32
SU 1
MA OA01.02
BP 36
EP 36
PG 1
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA EA6YH
UT WOS:000386774600051
ER
PT J
AU Wegmann, F
Alter, G
Nkolola, JP
Stephenson, KE
Borducchi, EN
Cabral, C
Seaman, MS
Zahn, R
Weijtens, M
Michael, NL
Robb, ML
Pau, MG
Schuitemaker, H
Barouch, DH
AF Wegmann, Frank
Alter, Galit
Nkolola, Joseph P.
Stephenson, Kathryn E.
Borducchi, Erica N.
Cabral, Crystal
Seaman, Michael S.
Zahn, Roland
Weijtens, Mo
Michael, Nelson L.
Robb, Merlin L.
Pau, Maria G.
Schuitemaker, Hanneke
Barouch, Dan H.
TI Protective Efficacy of Candidate Clinical HIV-1 Vaccine Regimens Against
SHIV-SF162P3 Challenges in Rhesus Monkeys
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Conference on HIV Research for Prevention (HIV R4P)
CY OCT 17-20, 2016
CL Chicago, IL
C1 [Wegmann, Frank; Zahn, Roland; Weijtens, Mo; Pau, Maria G.; Schuitemaker, Hanneke] Crucell Holland BV, Leiden, Netherlands.
[Alter, Galit; Stephenson, Kathryn E.; Barouch, Dan H.] Ragon Inst MGH MIT & Harvard, Cambridge, MA USA.
[Nkolola, Joseph P.; Stephenson, Kathryn E.; Borducchi, Erica N.; Cabral, Crystal; Seaman, Michael S.; Barouch, Dan H.] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Ctr Virol & Vaccine Res, Boston, MA USA.
[Michael, Nelson L.; Robb, Merlin L.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT
PY 2016
VL 32
SU 1
MA OA11.05
BP 68
EP 68
PG 1
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA EA6YH
UT WOS:000386774600114
ER
PT J
AU Herrera, C
Veazey, R
Schuetz, A
Olejniczak, N
Chenine, AL
Phogat, S
Sinangil, F
Nitayaphan, S
Kaewkungwal, J
Pitisuttithum, P
Rerks-Ngarm, S
Michael, NL
Robb, ML
Excler, JL
O'Connell, RJ
Vasan, S
Kim, JH
Shattock, RJ
AF Herrera, Carolina
Veazey, Ronald
Schuetz, Alexandra
Olejniczak, Natalia
Chenine, Agnes-Laurence
Phogat, Sanjay
Sinangil, Faruk
Nitayaphan, Sorachai
Kaewkungwal, Jaranit
Pitisuttithum, Punnee
Rerks-Ngarm, Supachai
Michael, Nelson L.
Robb, Merlin L.
Excler, Jean-Louis
O'Connell, Robert J.
Vasan, Sandhya
Kim, Jerome H.
Shattock, Robin J.
CA RV305 Study Grp
TI Ex Vivo Evaluation of Mucosal Cytokine Responses to in Vivo Vaccination
with ALVAC-HIV/AIDSVAX (R) B/E of Non-human Primates (NHPs) and Humans
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Conference on HIV Research for Prevention (HIV R4P)
CY OCT 17-20, 2016
CL Chicago, IL
C1 [Herrera, Carolina; Olejniczak, Natalia; Shattock, Robin J.] Imperial Coll London, London, England.
[Veazey, Ronald] Tulane Natl Primate Res Ctr, Covington, LA USA.
[Schuetz, Alexandra; Nitayaphan, Sorachai; O'Connell, Robert J.; Vasan, Sandhya] Armed Forces Res Inst Med Sci, Bangkok, Thailand.
[Schuetz, Alexandra; Chenine, Agnes-Laurence; Robb, Merlin L.; Vasan, Sandhya] Henry M Jackson Fdn Adv Mil Med, Washington, DC USA.
[Chenine, Agnes-Laurence; Michael, Nelson L.; Robb, Merlin L.; O'Connell, Robert J.; Vasan, Sandhya] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA.
[Phogat, Sanjay] Sanofi Pasteur, Swiftwater, PA USA.
[Sinangil, Faruk] Global Solut Infect Dis, San Francisco, CA USA.
[Kaewkungwal, Jaranit; Pitisuttithum, Punnee] Mahidol Univ, Bangkok, Thailand.
[Rerks-Ngarm, Supachai] Minist Publ Hlth, Bangkok, Thailand.
[Excler, Jean-Louis; Kim, Jerome H.] Int Vaccine Inst, Seoul, South Korea.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT
PY 2016
VL 32
SU 1
MA OA14.01
BP 75
EP 75
PG 1
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA EA6YH
UT WOS:000386774600128
ER
PT J
AU Eller, MA
Creegan, M
Costanzo, MC
Rerks-Ngarm, S
Pitisuttithum, P
Schuetz, A
Sinangil, F
Phogat, S
Robb, ML
Michael, NL
Excler, JL
Kim, JH
O'Connell, RJ
Vasan, S
AF Eller, Michael A.
Creegan, Matthew
Costanzo, Margaret C.
Rerks-Ngarm, Supachai
Pitisuttithum, Punnee
Schuetz, Alexandra
Sinangil, Faruk
Phogat, Sanjay
Robb, Merlin L.
Michael, Nelson L.
Excler, Jean-Louis
Kim, Jerome H.
O'Connell, Robert J.
Vasan, Sandhya
CA RV305 Study Grp
TI NK Cell Changes after a Late Boost with ALVAC-HIV and AIDSVAX (R) B/E in
HIV-Uninfected Thai Adults from RV144
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Conference on HIV Research for Prevention (HIV R4P)
CY OCT 17-20, 2016
CL Chicago, IL
C1 [Eller, Michael A.; Creegan, Matthew; Costanzo, Margaret C.; Schuetz, Alexandra; Robb, Merlin L.; Michael, Nelson L.; Excler, Jean-Louis; Kim, Jerome H.; O'Connell, Robert J.; Vasan, Sandhya] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA.
[Eller, Michael A.; Creegan, Matthew; Costanzo, Margaret C.; Schuetz, Alexandra; Robb, Merlin L.; Excler, Jean-Louis; Vasan, Sandhya] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA.
[Rerks-Ngarm, Supachai] Minist Publ Hlth, Bangkok, Thailand.
[Pitisuttithum, Punnee] Mahidol Univ, Fac Trop Med, Bangkok, Thailand.
[Schuetz, Alexandra; O'Connell, Robert J.; Vasan, Sandhya] Armed Forces Res Inst Med Sci, Bangkok, Thailand.
[Sinangil, Faruk] Global Solut Infect Dis, San Francisco, CA USA.
[Phogat, Sanjay] Sanofi Pasteur, Swiftwater, PA USA.
[Kim, Jerome H.] Int Vaccine Inst, Seoul, South Korea.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT
PY 2016
VL 32
SU 1
MA OA14.03
BP 76
EP 76
PG 1
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA EA6YH
UT WOS:000386774600130
ER
PT J
AU Ananthaswamy, N
Alsalmi, W
Mahalingam, M
Messina, E
Chand, S
Bose, M
Kijak, G
Sanders-Buell, E
Michael, N
Mangala, R
Eller, LA
Robb, M
Tovanabutra, S
Rao, V
AF Ananthaswamy, Neeti
Alsalmi, Wadad
Mahalingam, Marthandan
Messina, Emily
Chand, Subhash
Bose, Meera
Kijak, Gustavo
Sanders-Buell, Eric
Michael, Nelson
Mangala, Rao
Eller, Leigh Anne
Robb, Merlin
Tovanabutra, Sodsai
Rao, Venigalla
TI Characterization of Transmitted/Founder CRF01_AE Virus Envelope Trimers
from the RV217-early Capture HIV Cohort Study
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Conference on HIV Research for Prevention (HIV R4P)
CY OCT 17-20, 2016
CL Chicago, IL
C1 [Ananthaswamy, Neeti; Alsalmi, Wadad; Mahalingam, Marthandan; Messina, Emily; Chand, Subhash; Rao, Venigalla] Catholic Univ Amer, Washington, DC 20064 USA.
[Bose, Meera; Kijak, Gustavo; Sanders-Buell, Eric; Eller, Leigh Anne; Robb, Merlin; Tovanabutra, Sodsai] Henry M Jackson Fdn Adv Mil Med, US Mil HIV Res Program, Bethesda, MD USA.
[Michael, Nelson; Mangala, Rao] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT
PY 2016
VL 32
SU 1
MA OA21.01
BP 96
EP 96
PG 1
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA EA6YH
UT WOS:000386774600170
ER
PT J
AU Akapirat, S
Madnote, S
Pitisuttithum, P
Nitayaphan, S
Chariyalertsak, S
Puangkaew, J
Rittiroongrad, S
Chantakulkij, S
Phogat, S
Sinangil, F
Excler, JL
Robb, ML
Michael, NL
Kim, JH
Vasan, S
Connell, RJO
Karasavvas, N
AF Akapirat, Siriwat
Madnote, Sirinan
Pitisuttithum, Punnee
Nitayaphan, Sorachai
Chariyalertsak, Suwat
Puangkaew, Jiraporn
Rittiroongrad, Surawach
Chantakulkij, Somsak
Phogat, Sanjay
Sinangil, Faruk
Excler, Jean-Louis
Robb, Merlin L.
Michael, Nelson L.
Kim, Jerome H.
Vasan, Sandhya
Connell, Robert J. O.
Karasavvas, Nicos
CA RV306 Study Grp
TI Characterization of HIV-1 Envelope Antibody Responses Following
ALVAC-HIV and AIDSVAX B/E Prime-boost Vaccinations with Varying Late
Boosts (RV306)
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Conference on HIV Research for Prevention (HIV R4P)
CY OCT 17-20, 2016
CL Chicago, IL
C1 [Akapirat, Siriwat; Madnote, Sirinan; Nitayaphan, Sorachai; Puangkaew, Jiraporn; Rittiroongrad, Surawach; Chantakulkij, Somsak; Vasan, Sandhya; Connell, Robert J. O.; Karasavvas, Nicos] Armed Forces Res Inst Med Sci, Bangkok, Thailand.
[Pitisuttithum, Punnee] Mahidol Univ, Fac Trop Med, Bangkok, Thailand.
[Chariyalertsak, Suwat] Chiang Mai Univ, Res Inst Hlth Sci, Chiang Mai, Thailand.
[Phogat, Sanjay] Sanofi Pasteur, Swiftwater, PA USA.
[Sinangil, Faruk] Global Solut Infect Dis, San Francisco, CA USA.
[Excler, Jean-Louis; Kim, Jerome H.] Int Vaccine Inst, Seoul, South Korea.
[Robb, Merlin L.; Michael, Nelson L.; Vasan, Sandhya] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA.
[Robb, Merlin L.; Vasan, Sandhya] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT
PY 2016
VL 32
SU 1
MA OA22.04
BP 100
EP 100
PG 1
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA EA6YH
UT WOS:000386774600179
ER
PT J
AU Wieczorek, L
Pitisutthithum, P
Nitayaphan, S
Chariyalertsak, S
Kaewkungwal, J
Molnar, S
Blaskowski, S
Schoen, J
Gao, HM
Greene, K
Phogat, S
Sinagil, F
Michael, N
Excler, JL
Montefiori, D
Robb, M
Kim, J
Vasan, S
Connell, RO
Polonis, V
AF Wieczorek, Lindsay
Pitisutthithum, Punnee
Nitayaphan, Sorachai
Chariyalertsak, Suwat
Kaewkungwal, Jaranit
Molnar, Sebastian
Blaskowski, Stephen
Schoen, Jesse
Gao, Hongmei
Greene, Kelli
Phogat, Sanjay
Sinagil, Faruk
Michael, Nelson
Excler, Jean-Louis
Montefiori, David
Robb, Merlin
Kim, Jerome
Vasan, Sandhya
Connell, Robert O.
Polonis, Victoria
TI Delayed Boost of ALVAC (R) HIV and AIDSVAX (R) B/E gp120 Following the
RV144 Regimen, Significantly Increases HIV-1 Neutralizing Antibody
Responses
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Conference on HIV Research for Prevention (HIV R4P)
CY OCT 17-20, 2016
CL Chicago, IL
C1 [Wieczorek, Lindsay; Molnar, Sebastian; Blaskowski, Stephen; Schoen, Jesse; Michael, Nelson; Robb, Merlin; Vasan, Sandhya; Connell, Robert O.; Polonis, Victoria] US Mil HIV Res Program, Bethesda, MD USA.
[Wieczorek, Lindsay; Molnar, Sebastian; Blaskowski, Stephen; Schoen, Jesse; Robb, Merlin; Vasan, Sandhya] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA.
[Pitisutthithum, Punnee] Mahidol Univ, Bangkok, Thailand.
[Nitayaphan, Sorachai; Vasan, Sandhya; Connell, Robert O.] AFRIMS, Bangkok, Thailand.
[Chariyalertsak, Suwat; Kaewkungwal, Jaranit] RIHES, Chiang Mai, Thailand.
[Gao, Hongmei; Greene, Kelli; Montefiori, David] Duke Univ, Med Ctr, Durham, NC 27706 USA.
[Phogat, Sanjay] Sanofi Pasteur, Swiftwater, PA USA.
[Sinagil, Faruk] Global Solut Infect Dis, San Francisco, CA USA.
[Michael, Nelson; Polonis, Victoria] Walter Reed Army Inst Res, Silver Spring, MD USA.
[Excler, Jean-Louis; Kim, Jerome] Int Vaccine Inst, Seoul, South Korea.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT
PY 2016
VL 32
SU 1
MA OA22.03
BP 100
EP 100
PG 1
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA EA6YH
UT WOS:000386774600178
ER
PT J
AU Joachim, A
Nilsson, C
Onkar, S
Munseri, P
Aboud, S
Lyamuya, EF
Bakari, M
Billings, E
Robb, ML
Wahren, B
Mhalu, F
Sandstrom, E
Rao, M
Biberfeld, G
AF Joachim, Agricola
Nilsson, Charlotta
Onkar, Sayali
Munseri, Patricia
Aboud, Said
Lyamuya, Eligius F.
Bakari, Muhammad
Billings, Erik
Robb, Merlin L.
Wahren, Britta
Mhalu, Fred
Sandstrom, Eric
Rao, Mangala
Biberfeld, Gunnel
TI Frequent and Durable VIV2 Antibody Responses Induced by HIV-1 DNA
Priming Followed by HIV-MVA Boosting in Healthy Tanzanian Volunteers
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Conference on HIV Research for Prevention (HIV R4P)
CY OCT 17-20, 2016
CL Chicago, IL
C1 [Joachim, Agricola; Munseri, Patricia; Aboud, Said; Lyamuya, Eligius F.; Bakari, Muhammad; Mhalu, Fred] Muhimbili Univ Hlth & Allied Sci, Dar Es Salaam, Tanzania.
[Joachim, Agricola; Nilsson, Charlotta; Wahren, Britta; Biberfeld, Gunnel] Karolinska Inst, Stockholm, Sweden.
[Nilsson, Charlotta; Biberfeld, Gunnel] Publ Hlth Agcy Sweden, Stockholm, Sweden.
[Onkar, Sayali; Billings, Erik; Robb, Merlin L.] Henry M Jackson Fdn Adv Mil Med, US Mil HIV Res Program, Bethesda, MD USA.
[Onkar, Sayali; Billings, Erik; Robb, Merlin L.] Walter Reed Army Inst Res, Silver Spring, MD USA.
[Sandstrom, Eric] Karolinska Inst, Sodersjukhuset, Venhalsan, Stockholm, Sweden.
[Rao, Mangala] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT
PY 2016
VL 32
SU 1
MA PD01.04
BP 109
EP 109
PG 1
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA EA6YH
UT WOS:000386774600197
ER
PT J
AU Viegas, EO
Missanga, MT
Nilsson, C
Kroidl, A
Tembe, N
Bauer, A
Joseph, S
Geldmacher, C
Fleck, S
Stohr, W
Scarlatti, G
Bakari, M
Maboko, L
Wahren, B
Robb, ML
Biberfeld, G
Jani, IV
Sandstrom, E
Lyamuya, E
AF Viegas, Edna Omar
Missanga, Marco T.
Nilsson, Charlotta
Kroidl, Arne
Tembe, Nelson
Bauer, Asli
Joseph, Sarah
Geldmacher, Christof
Fleck, Sue
Stohr, Wolfgang
Scarlatti, Gabriella
Bakari, Muhammad
Maboko, Leonard
Wahren, Britta
Robb, Merlin L.
Biberfeld, Gunnel
Jani, Ilesh V.
Sandstrom, Eric
Lyamuya, Eligius
CA TaMoVac Study Grp
TI Intradermal Electroporation of HIV-DNA Vaccine Followed by HIV-MVA Boost
with or Without Addition of GLA Adjuvanted gp140
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Conference on HIV Research for Prevention (HIV R4P)
CY OCT 17-20, 2016
CL Chicago, IL
C1 [Viegas, Edna Omar; Tembe, Nelson; Jani, Ilesh V.] Inst Nacl Saude, Maputo, Mozambique.
[Viegas, Edna Omar; Nilsson, Charlotta; Tembe, Nelson; Wahren, Britta; Biberfeld, Gunnel] Karolinska Inst, Stockholm, Sweden.
[Viegas, Edna Omar; Tembe, Nelson] Eduardo Mondlane Univ, Maputo, Mozambique.
[Missanga, Marco T.; Bauer, Asli; Maboko, Leonard] Natl Inst Med Res, Dar Es Salaam, Tanzania.
[Nilsson, Charlotta; Biberfeld, Gunnel] Publ Hlth Agcy Sweden, Stockholm, Sweden.
[Kroidl, Arne; Geldmacher, Christof] Ludwig Maximillians Univ Munich, Med Ctr, Munich, Germany.
[Joseph, Sarah; Fleck, Sue; Stohr, Wolfgang] UCL, Clin Trials Unit, MRC, London, England.
[Scarlatti, Gabriella] Viral Evolut & Transmiss Unit, Milan, Italy.
[Bakari, Muhammad; Lyamuya, Eligius] Muhimbili Univ Hlth & Allied Sci, Dar Es Salaam, Tanzania.
[Robb, Merlin L.] Henry M Jackson Fdn Adv Mil Med, US Mil HIV Res Program, Bethesda, MD USA.
[Robb, Merlin L.] Walter Reed Army Inst Res, Silver Spring, MD USA.
[Sandstrom, Eric] Karolinska Inst, Sodersjukhuset, Stockholm, Sweden.
NR 0
TC 0
Z9 0
U1 2
U2 2
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT
PY 2016
VL 32
SU 1
MA PD01.03
BP 109
EP 109
PG 1
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA EA6YH
UT WOS:000386774600196
ER
PT J
AU Lee, A
Donofrio, G
Dussupt, V
Kong, R
Georgiev, I
Doria-Rose, N
Slike, B
Grande, R
Bryson, M
Mascola, J
Robb, M
Polonis, V
Michael, N
Krebs, S
AF Lee, Anna
Donofrio, Gina
Dussupt, Vincent
Kong, Rui
Georgiev, Ivelin
Doria-Rose, Nicole
Slike, Bonnie
Grande, Rebecca
Bryson, Mary
Mascola, John
Robb, Merlin
Polonis, Victoria
Michael, Nelson
Krebs, Shelly
TI Isolation of HIV Specific Monoclonal Antibodies Using a Combined
Antigen-specific and B Cell Culture Supernatant Method
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Conference on HIV Research for Prevention (HIV R4P)
CY OCT 17-20, 2016
CL Chicago, IL
C1 [Lee, Anna; Donofrio, Gina; Dussupt, Vincent; Slike, Bonnie; Grande, Rebecca; Bryson, Mary; Robb, Merlin; Polonis, Victoria; Michael, Nelson; Krebs, Shelly] Walter Reed Army Inst Res, US Mil HIV Res Program, Washington, DC USA.
[Lee, Anna; Donofrio, Gina; Dussupt, Vincent; Slike, Bonnie; Grande, Rebecca; Bryson, Mary; Robb, Merlin; Krebs, Shelly] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA.
[Kong, Rui; Doria-Rose, Nicole; Mascola, John] NIAID, Vaccine Res Ctr, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA.
[Georgiev, Ivelin] Vanderbilt Univ, 221 Kirkland Hall, Nashville, TN 37235 USA.
NR 0
TC 0
Z9 0
U1 3
U2 3
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT
PY 2016
VL 32
SU 1
MA P01.01
BP 132
EP 132
PG 1
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA EA6YH
UT WOS:000386774600231
ER
PT J
AU Gift, SK
Wieczorek, L
Krebs, SJ
Molnar, S
Donofrio, G
Chenine, AL
Sanders-Buell, E
Kijak, G
Chang, D
Doria-Rose, N
Rolland, M
Tovanabutra, S
Sriplienchan, S
Nitayapan, S
Connell, RJO
Eller, LA
Mascola, J
Michael, NL
Robb, ML
Polonis, VR
AF Gift, Syna K.
Wieczorek, Lindsay
Krebs, Shelly J.
Molnar, Sebastian
Donofrio, Gina
Chenine, Agnes-Laurence
Sanders-Buell, Eric
Kijak, Gustavo
Chang, David
Doria-Rose, Nicole
Rolland, Morgane
Tovanabutra, Sodsai
Sriplienchan, Somchai
Nitayapan, Sorachai
Connell, Robert J. O.
Eller, Leigh-Anne
Mascola, John
Michael, Nelson L.
Robb, Merlin L.
Polonis, Victoria R.
TI Development of Autologous Neutralizing Antibodies in HIV-1
CRF01_AE-infected Patients Spanning the First Three Years of Infection
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Conference on HIV Research for Prevention (HIV R4P)
CY OCT 17-20, 2016
CL Chicago, IL
C1 [Gift, Syna K.; Wieczorek, Lindsay; Krebs, Shelly J.; Molnar, Sebastian; Donofrio, Gina; Chenine, Agnes-Laurence; Sanders-Buell, Eric; Kijak, Gustavo; Chang, David; Rolland, Morgane; Tovanabutra, Sodsai; Eller, Leigh-Anne; Michael, Nelson L.; Robb, Merlin L.; Polonis, Victoria R.] US Mil HIV Res Program, Bethesda, MD USA.
[Gift, Syna K.; Wieczorek, Lindsay; Krebs, Shelly J.; Molnar, Sebastian; Donofrio, Gina; Chenine, Agnes-Laurence; Sanders-Buell, Eric; Kijak, Gustavo; Chang, David; Tovanabutra, Sodsai; Eller, Leigh-Anne; Robb, Merlin L.] Henry M Jackson Fdn Advancement Mil Med, Bethesda, MD USA.
[Doria-Rose, Nicole; Mascola, John] NIAID, Vaccine Res Ctr, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA.
[Sriplienchan, Somchai; Nitayapan, Sorachai; Connell, Robert J. O.] Armed Forces Res Inst Med Sci, Bangkok, Thailand.
[Michael, Nelson L.; Polonis, Victoria R.] Walter Reed Army Inst Res, Silver Spring, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT
PY 2016
VL 32
SU 1
MA P01.30
BP 146
EP 146
PG 1
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA EA6YH
UT WOS:000386774600259
ER
PT J
AU Teigler, JE
Eller, MA
Bolton, D
Marovich, M
Robb, ML
Martin, JN
Deeks, SG
Michael, NL
Streeck, H
AF Teigler, Jeffrey E.
Eller, Michael A.
Bolton, Diane
Marovich, Mary
Robb, Merlin L.
Martin, Jeffrey N.
Deeks, Steven G.
Michael, Nelson L.
Streeck, Hendrik
TI Differential Impact of Inhibitory Receptors and Inhibitory Receptor
Blockade on Cytokine-producing CD4 T Cell Subsets
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Conference on HIV Research for Prevention (HIV R4P)
CY OCT 17-20, 2016
CL Chicago, IL
C1 [Teigler, Jeffrey E.; Eller, Michael A.; Bolton, Diane; Robb, Merlin L.; Michael, Nelson L.; Streeck, Hendrik] Henry M Jackson Fdn Advancement Mil Med, Bethesda, MD USA.
[Teigler, Jeffrey E.; Eller, Michael A.; Bolton, Diane; Robb, Merlin L.; Michael, Nelson L.; Streeck, Hendrik] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA.
[Marovich, Mary] NIAID, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA.
[Martin, Jeffrey N.] Dept Epidemiol & Biostat, Bethesda, MD USA.
[Deeks, Steven G.] Univ Calif San Francisco, Sch Med, San Francisco, CA 94143 USA.
[Streeck, Hendrik] Inst HIV Res, Essen, Germany.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT
PY 2016
VL 32
SU 1
MA P03.08
BP 169
EP 169
PG 1
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA EA6YH
UT WOS:000386774600303
ER
PT J
AU Colby, D
Kroon, E
Wansom, T
Nitayaphan, S
Sriplienchan, S
Kitsiripornchai, S
Buapunth, P
Charuthamrong, P
Prasit, T
Michael, N
Robb, M
Connell, RO
AF Colby, Donn
Kroon, Eugene
Wansom, Tanyaporn
Nitayaphan, Sorachai
Sriplienchan, Somchai
Kitsiripornchai, Suchai
Buapunth, Puangmalee
Charuthamrong, Patchara
Prasit, Thunyasuta
Michael, Nelson
Robb, Merlin
Connell, Robert O.
CA RV217 Study Grp
TI Factors Associated with HIV Prevalence in a High-risk Cohort in Thailand
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Conference on HIV Research for Prevention (HIV R4P)
CY OCT 17-20, 2016
CL Chicago, IL
C1 [Colby, Donn; Kroon, Eugene] Red Cross AIDS Res Ctr, Bangkok, Thailand.
[Colby, Donn; Kroon, Eugene; Wansom, Tanyaporn; Nitayaphan, Sorachai; Sriplienchan, Somchai; Kitsiripornchai, Suchai; Buapunth, Puangmalee; Charuthamrong, Patchara; Prasit, Thunyasuta; Connell, Robert O.] Armed Forces Res Inst Med Sci, Bangkok, Thailand.
[Colby, Donn; Wansom, Tanyaporn; Robb, Merlin] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA.
[Michael, Nelson; Robb, Merlin; Connell, Robert O.] Walter Reed Army Inst Res, US Mil HIV Res Program, Washington, DC USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT
PY 2016
VL 32
SU 1
MA P09.07
BP 244
EP 244
PG 1
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA EA6YH
UT WOS:000386774600449
ER
PT J
AU Macicame, I
Bhatt, N
Matavele, R
Eller, LA
Monteiro, V
Viegas, E
Li, Q
Nwoga, C
Michael, N
Robb, M
Polyak, C
Jani, I
AF Macicame, Ivalda
Bhatt, Nilesh
Matavele, Raquel
Eller, Leigh Anne
Monteiro, Vanessa
Viegas, Edna
Li, Qun
Nwoga, Chiaka
Michael, Nelson
Robb, Merlin
Polyak, Christina
Jani, Ilesh
CA RV363 Study Grp
TI HIV Incidence Among High Risk Population Groups Living in a Peri-urban
Area of Maputo City, Mozambique: A Cohort Study
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Conference on HIV Research for Prevention (HIV R4P)
CY OCT 17-20, 2016
CL Chicago, IL
C1 [Macicame, Ivalda; Bhatt, Nilesh; Matavele, Raquel; Monteiro, Vanessa; Viegas, Edna; Jani, Ilesh] Minist Saude, Inst Nacl Saude, Maputo, Mozambique.
[Eller, Leigh Anne; Li, Qun; Nwoga, Chiaka; Michael, Nelson; Robb, Merlin; Polyak, Christina] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA.
Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT
PY 2016
VL 32
SU 1
MA P09.27LB
BP 254
EP 254
PG 1
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA EA6YH
UT WOS:000386774600468
ER
PT J
AU deCamp, AC
Rolland, M
Edlefsen, PT
Sanders-Buell, E
Hall, B
Magaret, C
Fiore-Gartland, AJ
Juraska, M
Graham, BS
Roederer, M
Michael, NL
Robb, ML
McElrath, J
Tovanabutra, S
Sobieszczyk, ME
Hammer, SM
Kim, JH
Mullins, JI
Gilbert, PB
AF deCamp, Allan C.
Rolland, Morgane
Edlefsen, Paul T.
Sanders-Buell, Eric
Hall, Breana
Magaret, Craig
Fiore-Gartland, Andrew J.
Juraska, Michal
Graham, Barney S.
Roederer, Mario
Michael, Nelson L.
Robb, Merlin L.
McElrath, Juliana
Tovanabutra, Sodsai
Sobieszczyk, Magdalena E.
Hammer, Scott M.
Kim, Jerome H.
Mullins, James I.
Gilbert, Peter B.
CA HVTN505 Sieve Anal Team
TI Sieve Pressure toward the CD4 Binding Site of Env in HVTN 505
Breakthrough Infections
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Conference on HIV Research for Prevention (HIV R4P)
CY OCT 17-20, 2016
CL Chicago, IL
C1 [deCamp, Allan C.; Edlefsen, Paul T.; Magaret, Craig; Fiore-Gartland, Andrew J.; Juraska, Michal; McElrath, Juliana; Gilbert, Peter B.] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA.
[Rolland, Morgane; Sanders-Buell, Eric; Michael, Nelson L.; Robb, Merlin L.; Tovanabutra, Sodsai] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA.
[Rolland, Morgane; Sanders-Buell, Eric; Michael, Nelson L.; Robb, Merlin L.; Tovanabutra, Sodsai] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA.
[Edlefsen, Paul T.; Hall, Breana; Mullins, James I.; Gilbert, Peter B.] Univ Washington, Seattle, WA 98195 USA.
[Graham, Barney S.; Roederer, Mario] NIAID, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA.
[Sobieszczyk, Magdalena E.; Hammer, Scott M.] Columbia Univ, Med Ctr, New York, NY 10027 USA.
[Kim, Jerome H.] Int Vaccine Inst, Seoul, South Korea.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT
PY 2016
VL 32
SU 1
MA P12.03
BP 260
EP 260
PG 1
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA EA6YH
UT WOS:000386774600477
ER
PT J
AU Rolland, M
Tovanabutra, S
Krebs, S
Sanders-Buell, E
Bose, M
Kijak, G
Sullivan, AMO
Harbolick, E
Bonar, L
Owen, C
Slike, B
Dussupt, V
Doria-Rose, N
Mascola, J
Nitayaphan, S
Polonis, V
Eller, LA
Kim, J
Michael, N
Robb, M
AF Rolland, Morgane
Tovanabutra, Sodsai
Krebs, Shelly
Sanders-Buell, Eric
Bose, Meera
Kijak, Gustavo
Sullivan, Anne Marie O.
Harbolick, Elizabeth
Bonar, Lydia
Owen, Christopher
Slike, Bonnie
Dussupt, Vincent
Doria-Rose, Nicole
Mascola, John
Nitayaphan, Sorachai
Polonis, Vicky
Eller, Leigh Anne
Kim, Jerome
Michael, Nelson
Robb, Merlin
TI Super-infection and Development of MPER-specific Neutralization Breadth
in Subject 40512 from the Acute Infection Cohort RV217
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Conference on HIV Research for Prevention (HIV R4P)
CY OCT 17-20, 2016
CL Chicago, IL
C1 [Rolland, Morgane; Tovanabutra, Sodsai; Krebs, Shelly; Sanders-Buell, Eric; Bose, Meera; Kijak, Gustavo; Sullivan, Anne Marie O.; Harbolick, Elizabeth; Bonar, Lydia; Owen, Christopher; Slike, Bonnie; Dussupt, Vincent; Eller, Leigh Anne; Robb, Merlin] Henry M Jackson Fdn Adv Mil Med, US Mil HIV Res Program, Bethesda, MD USA.
[Doria-Rose, Nicole; Mascola, John] NIAID, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA.
[Nitayaphan, Sorachai] Armed Forces Res Inst Med Sci AFRIMS, Bangkok, Thailand.
[Polonis, Vicky; Michael, Nelson] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA.
[Kim, Jerome] Int Vaccine Inst, Seoul, South Korea.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT
PY 2016
VL 32
SU 1
MA P12.20
BP 268
EP 268
PG 1
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA EA6YH
UT WOS:000386774600494
ER
PT J
AU Matyas, GR
Torres, OB
Jalah, R
Antoline, JFG
Peachman, KK
Beck, Z
Rao, M
Jacobson, AE
Michael, NL
Rice, KC
Alving, CR
AF Matyas, Gary R.
Torres, Oscar B.
Jalah, Rashmi
Antoline, Joshua F. G.
Peachman, Kristina K.
Beck, Zoltan
Rao, Mangala
Jacobson, Arthur E.
Michael, Nelson L.
Rice, Kenner C.
Alving, Carl R.
TI Development of a Combination HIV-heroin Vaccine
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Conference on HIV Research for Prevention (HIV R4P)
CY OCT 17-20, 2016
CL Chicago, IL
C1 [Matyas, Gary R.; Rao, Mangala; Michael, Nelson L.; Alving, Carl R.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA.
[Torres, Oscar B.; Jalah, Rashmi; Peachman, Kristina K.; Beck, Zoltan] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA.
[Antoline, Joshua F. G.; Jacobson, Arthur E.; Rice, Kenner C.] NIDA, NIH, Bethesda, MD 20892 USA.
[Antoline, Joshua F. G.; Jacobson, Arthur E.; Rice, Kenner C.] NIAAA, NIH, Bethesda, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT
PY 2016
VL 32
SU 1
MA P19.13
BP 328
EP 328
PG 1
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA EA6YH
UT WOS:000386774600608
ER
PT J
AU Dhitavat, J
Phonrat, B
Nitayaphan, S
Chariyalertsak, S
Kaewkungwal, J
Khowsroy, K
Lapwech, W
Kaewthit, O
Jarujareet, P
Karasavvas, N
Akapirat, S
Phramtong, A
Vasan, S
Robb, M
Michael, N
Connell, RO
Pitisuttithum, P
AF Dhitavat, Jittima
Phonrat, Benjaluck
Nitayaphan, Sorachai
Chariyalertsak, Suwat
Kaewkungwal, Jaranit
Khowsroy, Kessuda
Lapwech, Wanlaya
Kaewthit, Oranitcha
Jarujareet, Pawinee
Karasavvas, Nicos
Akapirat, Sirwat
Phramtong, Anant
Vasan, Sandhya
Robb, Merlin
Michael, Nelson
Connell, Robert O.
Pitisuttithum, Punnee
CA RV306 Study Grp
TI Characterization of Factors Associated with Mucosal Secretion
Collections and Biopsies in RV306 Study
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Conference on HIV Research for Prevention (HIV R4P)
CY OCT 17-20, 2016
CL Chicago, IL
C1 [Dhitavat, Jittima; Phonrat, Benjaluck; Khowsroy, Kessuda; Pitisuttithum, Punnee] Mahidol Univ, Fac Trop Med, Salaya, Thailand.
[Nitayaphan, Sorachai; Lapwech, Wanlaya; Karasavvas, Nicos; Akapirat, Sirwat; Phramtong, Anant; Vasan, Sandhya; Connell, Robert O.] Armed Forces Res Inst Med Sci, Bangkok, Thailand.
[Chariyalertsak, Suwat; Kaewthit, Oranitcha] Chiang Mai Univ, Res Inst Hlth Sci, Chiang Mai, Thailand.
[Kaewkungwal, Jaranit; Jarujareet, Pawinee] Mahidol Univ, Fac Trop Med, Ctr Excellence Biomed & Publ Hlth Informat, Salaya, Thailand.
[Robb, Merlin] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA.
[Michael, Nelson] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT
PY 2016
VL 32
SU 1
MA P25.07
BP 392
EP 392
PG 1
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA EA6YH
UT WOS:000386774600732
ER
PT J
AU Nadai, Y
Ahmed, MIM
Joseph, S
Missanga, M
Bauer, A
Cope, AV
Joachim, A
Reimer, U
Pollakis, G
McCormack, S
Tatoud, R
Shattock, RJ
Robb, M
Sandstroem, E
Hoelscher, M
Bakari, M
Maboko, L
Kroidl, A
Weber, J
Geldmacher, C
Held, K
AF Nadai, Yuka
Ahmed, Mohamed I. M.
Joseph, Sarah
Missanga, Marco
Bauer, Asli
Cope, Alethea V.
Joachim, Agricola
Reimer, Ulf
Pollakis, Georgios
McCormack, Sheena
Tatoud, Roger
Shattock, Robin J.
Robb, Merlin
Sandstroem, Eric
Hoelscher, Michael
Bakari, Muhammad
Maboko, Leonard
Kroidl, Arne
Weber, Jonathan
Geldmacher, Christof
Held, Kathrin
TI Env-specific IgG Responses Induced by Identical and None-identical
Immunogen Prime-boost Vaccination Strategies Target Different Antigenic
Regions
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Conference on HIV Research for Prevention (HIV R4P)
CY OCT 17-20, 2016
CL Chicago, IL
C1 [Nadai, Yuka; Ahmed, Mohamed I. M.; Bauer, Asli; Hoelscher, Michael; Kroidl, Arne; Geldmacher, Christof; Held, Kathrin] Ludwig Maximillians Univ Munich, Med Ctr, Munich, Germany.
[Joseph, Sarah; McCormack, Sheena] UCL, London WC1E 6BT, England.
[Missanga, Marco; Bauer, Asli; Maboko, Leonard] Natl Inst Med Res, Mbeya Med Res Ctr, Dar Es Salaam, Tanzania.
[Cope, Alethea V.; Tatoud, Roger; Shattock, Robin J.; Weber, Jonathan] Imperial Coll London, London, England.
[Joachim, Agricola; Bakari, Muhammad] Muhimbili Univ Hlth & Allied Sci, Dar Es Salaam, Tanzania.
[Reimer, Ulf] JPT Peptide Technol, Berlin, Germany.
[Pollakis, Georgios] Univ Liverpool, Liverpool L69 3BX, Merseyside, England.
[Robb, Merlin] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA.
[Sandstroem, Eric] Karolinska Inst Sodersjukhuset, Solna, Sweden.
[Hoelscher, Michael; Kroidl, Arne; Geldmacher, Christof; Held, Kathrin] German Ctr Infect Res DZIF, Braunschweig, Germany.
RI Hoelscher, Michael/D-3436-2012
NR 0
TC 0
Z9 0
U1 3
U2 3
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT
PY 2016
VL 32
SU 1
MA P25.08
BP 392
EP 392
PG 1
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA EA6YH
UT WOS:000386774600733
ER
PT J
AU Wansom, T
Akiparat, S
Pitisutthitum, P
Nitayaphan, S
Chariyalertsak, S
Eamsila, C
Wongwarapat, K
Karasavvas, N
Sinangil, F
Phogat, S
Robb, M
Michael, N
Kim, J
Vasan, S
O'Connell, R
AF Wansom, Tanyaporn
Akiparat, Siriwat
Pitisutthitum, Punnee
Nitayaphan, Sorachai
Chariyalertsak, Suwat
Eamsila, Chirapa
Wongwarapat, Kanlaya
Karasavvas, Nicos
Sinangil, Faruk
Phogat, Sanjay
Robb, Merlin
Michael, Nelson
Kim, Jerome
Vasan, Sandhya
O'Connell, Robert
CA RV 306 Study Grp
TI Vaccine Induced Seroreactivity Induced by ALVAC-HIV and AIDSVAXB/E
Prime-boost Vaccinations with Varying Late Boosts (RV306)
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Conference on HIV Research for Prevention (HIV R4P)
CY OCT 17-20, 2016
CL Chicago, IL
C1 [Wansom, Tanyaporn; Akiparat, Siriwat; Nitayaphan, Sorachai; Eamsila, Chirapa; Karasavvas, Nicos; Vasan, Sandhya; O'Connell, Robert] Armed Forces Res Inst Med Sci, Bangkok, Thailand.
[Wansom, Tanyaporn; Robb, Merlin; Vasan, Sandhya] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA.
[Pitisutthitum, Punnee] Mahidol Univ, Salaya, Thailand.
[Chariyalertsak, Suwat; Wongwarapat, Kanlaya] Chiang Mai Univ, Res Inst Hlth Sci, Chiang Mai, Thailand.
[Sinangil, Faruk] Global Solut Infect Dis, Princeton, NJ USA.
[Phogat, Sanjay] Sanofi Pasteur, Swiftwater, PA USA.
[Robb, Merlin; Michael, Nelson] Walter Reed Army Inst Res, US Mil HIV Res Program, Washington, DC USA.
[Kim, Jerome] Int Vaccine Inst, Seoul, South Korea.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT
PY 2016
VL 32
SU 1
MA P25.18
BP 397
EP 397
PG 1
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA EA6YH
UT WOS:000386774600743
ER
PT J
AU Issac, B
Ehrenberg, P
Eller, M
Eller, LA
Kroon, E
Ananworanich, J
Michael, N
Robb, M
Thomas, R
AF Issac, Biju
Ehrenberg, Philip
Eller, Michael
Eller, Leigh Anne
Kroon, Eugene
Ananworanich, Jintanat
Michael, Nelson
Robb, Merlin
Thomas, Rasmi
CA RV 217 Study Grp
RV 254 Study Grp
TI Whole Transcriptome Analysis of Longitudinally Sampled Acutely Infected
HIV Patients by RNA Sequencing
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Meeting Abstract
CT Conference on HIV Research for Prevention (HIV R4P)
CY OCT 17-20, 2016
CL Chicago, IL
C1 [Issac, Biju; Ehrenberg, Philip; Eller, Michael; Eller, Leigh Anne; Ananworanich, Jintanat; Michael, Nelson; Robb, Merlin; Thomas, Rasmi] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA.
Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA.
[Kroon, Eugene] Thai Red Cross AIDS Res Ctr, SEARCH, Bangkok, Thailand.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT
PY 2016
VL 32
SU 1
MA P26.03LB
BP 401
EP 401
PG 1
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA EA6YH
UT WOS:000386774600749
ER
PT J
AU Roberts, KK
Pathirana, IN
Paredes, AH
Lisanti, CJ
Schwope, R
Cebe, KM
Aldridge-Whitehead, JM
Aden, JK
Harrison, SA
AF Roberts, Katharine K.
Pathirana, Induruwa N.
Paredes, Angelo H.
Lisanti, Christopher J.
Schwope, Ryan
Cebe, Katherine M.
Aldridge-Whitehead, Jennifer M.
Aden, James K.
Harrison, Stephen A.
TI Prospective Comparison to Liver Biopsy of VCTE/CAP, MRE, PDFF, and
Multiparametric MRI for Predicting Degree of Steatosis and Diagnosis of
NASH
SO HEPATOLOGY
LA English
DT Meeting Abstract
CT 67th Annual Meeting of the
American-Association-for-the-Study-of-Liver-Diseases (AASLD)
CY NOV 11-15, 2016
CL Boston, MA
SP Amer Assoc Study Liver Dis
C1 [Roberts, Katharine K.; Pathirana, Induruwa N.; Paredes, Angelo H.; Harrison, Stephen A.] Brooke Army Med Ctr, Gastroenterol, Ft Sam Houston, TX 78234 USA.
[Lisanti, Christopher J.; Schwope, Ryan; Aldridge-Whitehead, Jennifer M.] Brooke Army Med Ctr, Radiol, Ft Sam Houston, TX 78234 USA.
[Cebe, Katherine M.] Brooke Army Med Ctr, Pathol, Ft Sam Houston, TX 78234 USA.
[Aden, James K.] Inst Surg Res, Biomed Stat, Ft Sam Houston, TX USA.
NR 0
TC 0
Z9 0
U1 2
U2 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0270-9139
EI 1527-3350
J9 HEPATOLOGY
JI Hepatology
PD OCT
PY 2016
VL 64
SU 1
MA 42
BP 22A
EP 22A
PG 1
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA DY9YT
UT WOS:000385493800043
ER
PT J
AU Paredes, AH
Roberts, KK
Pathirana, IN
Cochet, AE
Manibusan, PA
Lisanti, CJ
Schwope, R
George, AA
Cebe, KM
Aden, JK
Aldridge-Whitehead, JM
Thomas, DM
Harrison, SA
AF Paredes, Angelo H.
Roberts, Katharine K.
Pathirana, Induruwa N.
Cochet, Allyson E.
Manibusan, Pedro A.
Lisanti, Christopher J.
Schwope, Ryan
George, Alan A.
Cebe, Katherine M.
Aden, James K.
Aldridge-Whitehead, Jennifer M.
Thomas, Dustin M.
Harrison, Stephen A.
TI Prospective Prevalence of Non-alcoholic Fatty Liver Disease (NAFLD) and
Non-alcoholic Steatohepatitis (NASH) Among a Largely Middle-Aged
Population Utilizing FibroScan (R), Liver MultiScan (LMS), Magnetic
Resonance Elastography (MRE), and Liver Biopsy: Interim Analysis
SO HEPATOLOGY
LA English
DT Meeting Abstract
CT 67th Annual Meeting of the
American-Association-for-the-Study-of-Liver-Diseases (AASLD)
CY NOV 11-15, 2016
CL Boston, MA
SP Amer Assoc Study Liver Dis
C1 [Paredes, Angelo H.; Roberts, Katharine K.; Pathirana, Induruwa N.; Cochet, Allyson E.; Manibusan, Pedro A.; Harrison, Stephen A.] Brooke Army Med Ctr, Gastroenterol, Ft Sam Houston, TX 78234 USA.
[Lisanti, Christopher J.; Schwope, Ryan; Aldridge-Whitehead, Jennifer M.] Brooke Army Med Ctr, Radiol, Ft Sam Houston, TX 78234 USA.
[George, Alan A.; Cebe, Katherine M.] Brooke Army Med Ctr, Pathol, Ft Sam Houston, TX 78234 USA.
[Aden, James K.] Inst Surg Res, Biomed Stat, Ft Sam Houston, TX USA.
[Thomas, Dustin M.] Brooke Army Med Ctr, Cardiol, Ft Sam Houston, TX 78234 USA.
NR 0
TC 0
Z9 0
U1 2
U2 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0270-9139
EI 1527-3350
J9 HEPATOLOGY
JI Hepatology
PD OCT
PY 2016
VL 64
SU 1
MA 1051
BP 530A
EP 530A
PG 1
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA DY9YT
UT WOS:000385493802318
ER
PT J
AU Bush, KN
Prentice, RI
Fentanes, E
Hilliard, RW
Lisanti, CJ
Schwope, R
Cebe, KM
Manibusan, PA
Paredes, AH
Aden, JK
Watts, J
Thomas, DM
Harrison, SA
AF Bush, Kelvin N.
Prentice, Ryan I.
Fentanes, Emilio
Hilliard, Richard W.
Lisanti, Christopher J.
Schwope, Ryan
Cebe, Katherine M.
Manibusan, Pedro A.
Paredes, Angelo H.
Aden, James K.
Watts, James
Thomas, Dustin M.
Harrison, Stephen A.
TI The Presence and Severity of Coronary Artery Disease in Patients with
Biopsy-Proven NAFLD: A Prospective Prevalence Study
SO HEPATOLOGY
LA English
DT Meeting Abstract
CT 67th Annual Meeting of the
American-Association-for-the-Study-of-Liver-Diseases (AASLD)
CY NOV 11-15, 2016
CL Boston, MA
SP Amer Assoc Study Liver Dis
C1 [Manibusan, Pedro A.; Paredes, Angelo H.; Harrison, Stephen A.] Brooke Army Med Ctr, Gastroenterol, Ft Sam Houston, TX 78234 USA.
[Bush, Kelvin N.; Prentice, Ryan I.; Fentanes, Emilio; Hilliard, Richard W.; Watts, James; Thomas, Dustin M.] Brooke Army Med Ctr, Cardiol, Ft Sam Houston, TX 78234 USA.
[Lisanti, Christopher J.; Schwope, Ryan] Brooke Army Med Ctr, Radiol, Ft Sam Houston, TX 78234 USA.
[Cebe, Katherine M.] Brooke Army Med Ctr, Pathol, Ft Sam Houston, TX 78234 USA.
[Aden, James K.] Inst Surg Res, Biomed Stat, Ft Sam Houston, TX USA.
NR 0
TC 0
Z9 0
U1 2
U2 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0270-9139
EI 1527-3350
J9 HEPATOLOGY
JI Hepatology
PD OCT
PY 2016
VL 64
SU 1
MA 1110
BP 560A
EP 560A
PG 1
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA DY9YT
UT WOS:000385493802377
ER
PT J
AU Cholankeril, G
Perumpail, RB
Hu, M
Jayasekera, CR
Holt, EW
Gonzalez, SA
Harrison, SA
Younossi, ZM
Wong, RJ
Ahmed, A
AF Cholankeril, George
Perumpail, Ryan B.
Hu, Menghan
Jayasekera, Channa R.
Holt, Edward W.
Gonzalez, Stevan A.
Harrison, Stephen A.
Younossi, Zobair M.
Wong, Robert J.
Ahmed, Aijaz
TI Geographic Variation in Nonalcoholic Steatohepatitis-Related Liver
Transplantation
SO HEPATOLOGY
LA English
DT Meeting Abstract
CT 67th Annual Meeting of the
American-Association-for-the-Study-of-Liver-Diseases (AASLD)
CY NOV 11-15, 2016
CL Boston, MA
SP Amer Assoc Study Liver Dis
C1 [Cholankeril, George] Roger Williams Med Ctr, Providence, RI USA.
[Cholankeril, George] Boston Univ, Sch Med, Internal Med, Boston, MA 02118 USA.
[Perumpail, Ryan B.; Ahmed, Aijaz] Stanford Univ, Sch Med, Div Gastroenterol & Hepatol, Stanford, CA 94305 USA.
[Hu, Menghan] Brown Univ, Sch Publ Hlth, Biostat, Providence, RI 02912 USA.
[Jayasekera, Channa R.; Holt, Edward W.] Calif Pacific Med Ctr, Hepatol, San Francisco, CA USA.
[Gonzalez, Stevan A.] Baylor All St Med Ctr, Simmons Transplant Inst, Hepatol, Ft Worth, TX USA.
[Harrison, Stephen A.] Brooke Army Med Ctr, Gastroenterol & Hepatol, Ft Sam Houston, TX 78234 USA.
[Younossi, Zobair M.] Inova Fairfax Hosp, Dept Med, Ctr Liver Dis, Falls Church, VA USA.
[Wong, Robert J.] Alameda Hlth Syst Highland Hosp, Div Gastroenterol & Hepatol, Oakland, CA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0270-9139
EI 1527-3350
J9 HEPATOLOGY
JI Hepatology
PD OCT
PY 2016
VL 64
SU 1
MA 1111
BP 560A
EP 561A
PG 2
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA DY9YT
UT WOS:000385493802378
ER
PT J
AU Harrison, SA
Barstow, K
Allgood, AE
Traber, PG
AF Harrison, Stephen A.
Barstow, Karol
Allgood, Adam E.
Traber, Peter G.
TI Baseline patient characteristics and non-invasive image analysis in a
Phase 2 therapeutic trial of GR-MD-02 in NASH patients with stage 3
fibrosis
SO HEPATOLOGY
LA English
DT Meeting Abstract
CT 67th Annual Meeting of the
American-Association-for-the-Study-of-Liver-Diseases (AASLD)
CY NOV 11-15, 2016
CL Boston, MA
SP Amer Assoc Study Liver Dis
C1 [Harrison, Stephen A.; Barstow, Karol] Brooke Army Med Ctr, Gastroenterol, Ft Sam Houston, TX 78234 USA.
[Allgood, Adam E.; Traber, Peter G.] Galectin Therapeut, Norcross, GA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0270-9139
EI 1527-3350
J9 HEPATOLOGY
JI Hepatology
PD OCT
PY 2016
VL 64
SU 1
MA 1151
BP 580A
EP 580A
PG 1
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA DY9YT
UT WOS:000385493802418
ER
PT J
AU Ratziu, V
Harrison, SA
Francque, S
Bedossa, P
Anstee, QM
Ben Sudrik, F
Roudot, A
Megnien, S
Hum, DW
Hanf, R
Staels, B
Sanyal, AJ
AF Ratziu, Vlad
Harrison, Stephen A.
Francque, Sven
Bedossa, Pierre
Anstee, Quentin M.
Ben Sudrik, Fouad
Roudot, Alice
Megnien, Sophie
Hum, Dean W.
Hanf, RMy
Staels, Bart
Sanyal, Arun J.
TI ALT as a non-invasive biomarker of histological response to
pharmacotherapy in NASH patients: insights from the elafibranor
GOLDEN505 trial
SO HEPATOLOGY
LA English
DT Meeting Abstract
CT 67th Annual Meeting of the
American-Association-for-the-Study-of-Liver-Diseases (AASLD)
CY NOV 11-15, 2016
CL Boston, MA
SP Amer Assoc Study Liver Dis
C1 [Ratziu, Vlad] Hop La Pitie Salpetriere, Hepatol, Paris, France.
[Ratziu, Vlad] Inst Cardometab & Nutr, Paris, France.
[Harrison, Stephen A.] Brooke Army Med Ctr, Ft Worth, TX USA.
[Francque, Sven] Univ Antwerp, Antwerp, Belgium.
[Bedossa, Pierre] Hop Beaujon, Clichy, France.
[Anstee, Quentin M.] Newcastle Univ, Newcastle Upon Tyne, Tyne & Wear, England.
[Ben Sudrik, Fouad; Roudot, Alice; Megnien, Sophie; Hum, Dean W.; Hanf, RMy] Genfit, Loos, France.
[Sanyal, Arun J.] Virginia Commonwealth Univ, Richmond, VA USA.
[Staels, Bart] Univ Lille 2, EGID, INSERM U1011, Lille, France.
RI Staels, Bart/N-9497-2016
OI Staels, Bart/0000-0002-3784-1503
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0270-9139
EI 1527-3350
J9 HEPATOLOGY
JI Hepatology
PD OCT
PY 2016
VL 64
SU 1
MA 1154
BP 581A
EP 582A
PG 2
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA DY9YT
UT WOS:000385493802421
ER
PT J
AU Vuppalanchi, R
Abdelmalek, MF
Lawitz, E
Traber, PG
Allgood, AE
Harrison, SA
Goodman, ZD
Chalasani, NP
Garcia-Tsao, G
AF Vuppalanchi, Raj
Abdelmalek, Manal F.
Lawitz, Eric
Traber, Peter G.
Allgood, Adam E.
Harrison, Stephen A.
Goodman, Zachary D.
Chalasani, Naga P.
Garcia-Tsao, Guadalupe
TI Vibration-Controlled Transient Elastography (VCTE) is Useful in
Identifying Clinically Significant Portal Hypertension in Patients with
NASH Cirrhosis
SO HEPATOLOGY
LA English
DT Meeting Abstract
CT 67th Annual Meeting of the
American-Association-for-the-Study-of-Liver-Diseases (AASLD)
CY NOV 11-15, 2016
CL Boston, MA
SP Amer Assoc Study Liver Dis
C1 [Vuppalanchi, Raj; Chalasani, Naga P.] Indiana Univ, Indianapolis, IN 46204 USA.
[Lawitz, Eric] Texas Liver Inst, San Antonio, TX USA.
[Abdelmalek, Manal F.] Duke Hlth, Durham, NC USA.
[Traber, Peter G.; Allgood, Adam E.] Galectin Therapeut Inc, Norcross, GA USA.
[Harrison, Stephen A.] Brooke Army Med Ctr, San Antonio, TX USA.
[Goodman, Zachary D.] Inova Fairfax Hosp, Falls Church, VA USA.
[Garcia-Tsao, Guadalupe] Yale Digest Dis, New Haven, CT USA.
[Garcia-Tsao, Guadalupe] VA CT Healthcare Syst, West Haven, CT USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0270-9139
EI 1527-3350
J9 HEPATOLOGY
JI Hepatology
PD OCT
PY 2016
VL 64
SU 1
MA 1709
BP 844A
EP 845A
PG 2
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA DY9YT
UT WOS:000385493804071
ER
PT J
AU Kaiser, AP
Proctor, SP
Vasterling, JJ
AF Kaiser, Anica Pless
Proctor, Susan P.
Vasterling, Jennifer J.
TI Consistency of Reporting for Stressful Life Events Among Nondeployed
Soldiers
SO JOURNAL OF CLINICAL PSYCHOLOGY
LA English
DT Article
DE assessment; posttraumatic stress disorder; stressful life events;
inconsistent reporting; veterans
ID NEUROCOGNITION DEPLOYMENT HEALTH; POTENTIALLY TRAUMATIC EVENTS;
POSTTRAUMATIC-STRESS; MEMORY; VETERANS; EXPOSURE; RECALL; STABILITY;
SYMPTOMS; PTSD
AB ObjectivesMeasurement of stress exposure is central to understanding military mental health outcomes. Although temporal stability of combat event reporting has been examined, less is known about the stability of reporting for noncombat events in military samples. Objectives are to examine consistency in reporting stressful life events in nondeployed U.S. Army soldiers and its association with posttraumatic stress disorder (PTSD) symptomatology.
MethodExamined reporting consistency over approximately 8 months among 466 soldiers. Regression models examined factors associated with decreased, increased, and stable reporting.
ResultsStability of the number of events endorsed over time was high. However, item-level agreement was slight to moderate (kappas: .13-.54), with inconsistencies due primarily to decreased reporting. After adjusting for covariates and initial PTSD, second assessment PTSD was associated with increased and stable reporting.
ConclusionsInconsistent reporting extends beyond combat events to other stressful life events in military personnel and is associated with PTSD.
C1 [Kaiser, Anica Pless; Vasterling, Jennifer J.] VA Boston Healthcare Syst, Behav Sci Div, VA Natl Ctr PTSD, Boston, MA USA.
[Kaiser, Anica Pless; Vasterling, Jennifer J.] Boston Univ, Sch Med, Boston, MA 02215 USA.
[Proctor, Susan P.] US Army, Environm Med Res Inst, Mil Performance Div, Natick, MA USA.
[Proctor, Susan P.] VA Boston Healthcare Syst, 150 S Huntington Ave,116B-2, Boston, MA 02130 USA.
[Proctor, Susan P.] Boston Univ, Sch Publ Hlth, Boston, MA 02215 USA.
RP Kaiser, AP (reprint author), VA Boston Healthcare Syst, 150 S Huntington Ave,116B-2, Boston, MA 02130 USA.
EM Anica.PlessKaiser@va.gov
FU U.S. Army Medical Research and Material Command [DAMD 17-03-0020];
Department of Veterans Affairs, Clinical Science Research and
Development
FX Support for this study was provided by the U.S. Army Medical Research
and Material Command (DAMD 17-03-0020) and the Department of Veterans
Affairs, Clinical Science Research and Development. The manuscript
underwent scientific and administrative review at the U.S. Army Research
Institute of Environmental Medicine. The views expressed in this
manuscript are those of the authors and do not reflect the official
policy or position of the Department of the Army or Department of
Veterans Affairs.
NR 31
TC 0
Z9 0
U1 3
U2 3
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-9762
EI 1097-4679
J9 J CLIN PSYCHOL
JI J. Clin. Psychol.
PD OCT
PY 2016
VL 72
IS 10
BP 1088
EP 1098
DI 10.1002/jclp.22311
PG 11
WC Psychology, Clinical
SC Psychology
GA DW5TO
UT WOS:000383710000008
ER
PT J
AU Gissel, M
Brummel-Ziedins, KE
Butenas, S
Pusateri, AE
Mann, KG
Orfeo, T
AF Gissel, M.
Brummel-Ziedins, K. E.
Butenas, S.
Pusateri, A. E.
Mann, K. G.
Orfeo, T.
TI Effects of an acidic environment on coagulation dynamics
SO JOURNAL OF THROMBOSIS AND HAEMOSTASIS
LA English
DT Article
DE acidosis; blood coagulation; blood coagulation factor inhibitors;
thromboelastography; trauma
ID TRAUMA-INDUCED COAGULOPATHY; FACTOR PATHWAY INHIBITOR; PORCINE
FACTOR-VIII; THROMBIN GENERATION; BLOOD-COAGULATION; A1/A3-C1-C2 DIMER;
WHOLE-BLOOD; ACIDOSIS; HYPOTHERMIA; PH
AB Background Disruption of hydrogen ion homeostasis is a consequence of traumatic injury often associated with clinical coagulopathy. Mechanisms by which acidification of the blood leads to aberrant coagulation require further elucidation.
Objective To examine the effects of acidified conditions on coagulation dynamics using in vitro models of increasing complexity.
Methods Coagulation dynamics were assessed at pH 7.4 and 7.0 as follows: (i) tissue factor (TF)-initiated coagulation proteome mixtures (factor [F]XI, fibrinogen/FXIII), with reaction progress monitored as thrombin generation or fibrin formation; (ii) enzyme/inhibitor reactions; and (iii) TF-dependent or independent clot dynamics in contact pathway-inhibited blood via viscoelastometry.
Results Rate constants for antithrombin inhibition of FXa and thrombin were reduced by 25-30% at pH 7.0. At pH 7.0 (+FXI), TF-initiated thrombin generation showed a 20% increase in maximum thrombin levels and diminished thrombin clearance rates. Viscoelastic analyses showed a 25% increase in clot time and a 25% reduction in maximum clot firmness (MCF). A similar MCF reduction was observed at pH 7.0 when fibrinogen/FXIII were reacted with thrombin. In contrast, in contact pathway-inhibited blood (n = 6) at pH 7.0, MCF values were elevated 6% (95% confidence interval [CI]: 1%-11%) in TF-initiated blood and 15% (95% CI: 1%- 29%) in the absence of TF. Clot times at pH 7.0 decreased 32% (95% CI: 15%-49%) in TF-initiated blood and 51% (95% CI: 35%-68%) in the absence of TF.
Conclusions Despite reported decreased procoagulant catalysis at pH 7.0, clot formation dynamics are slightly enhanced in blood ex vivo and suppression of thrombin generation is not observed. A decrease in antithrombin reactivity is one potential mechanism contributing to these outcomes.
C1 [Gissel, M.; Brummel-Ziedins, K. E.; Butenas, S.; Orfeo, T.] Univ Vermont, Dept Biochem, 360 South Pk Dr,Room 248, Colchester, VT 05446 USA.
[Pusateri, A. E.] US Army Med Res & Mat Command, Ft Detrick, MD USA.
[Mann, K. G.] Haematol Technol, Essex Jct, VT USA.
RP Orfeo, T (reprint author), Univ Vermont, Dept Biochem, 360 South Pk Dr,Room 248, Colchester, VT 05446 USA.
EM torfeo@uvm.edu
FU United States Army Research Office [W911NF-10-1-0376]; United States
Naval Health Research Center [W911QY-15-C-0027]
FX This study was supported by United States Army Research Office grant
W911NF-10-1-0376 and by United States Naval Health Research Center
contract W911QY-15-C-0027.
NR 43
TC 0
Z9 0
U1 1
U2 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1538-7933
EI 1538-7836
J9 J THROMB HAEMOST
JI J. Thromb. Haemost.
PD OCT
PY 2016
VL 14
IS 10
BP 2001
EP 2010
DI 10.1111/jth.13418
PG 10
WC Hematology; Peripheral Vascular Disease
SC Hematology; Cardiovascular System & Cardiology
GA EA9IL
UT WOS:000386956200013
PM 27431334
ER
PT J
AU Haddow, AD
Nasar, F
Guzman, H
Ponlawat, A
Jarman, RG
Tesh, RB
Weaver, SC
AF Haddow, Andrew D.
Nasar, Farooq
Guzman, Hilda
Ponlawat, Alongkot
Jarman, Richard G.
Tesh, Robert B.
Weaver, Scott C.
TI Genetic Characterization of Spondweni and Zika Viruses and
Susceptibility of Geographically Distinct Strains of Aedes aegypti,
Aedes albopictus and Culex quinquefasciatus (Diptera: Culicidae) to
Spondweni Virus
SO PLOS NEGLECTED TROPICAL DISEASES
LA English
DT Article
ID ARTHROPOD-BORNE VIRUSES; YELLOW-FEVER VIRUS; SOUTH-AFRICA; INDIGENOUS
RESIDENTS; SEQUENCE ALIGNMENT; DENGUE VIRUSES; ASIAN-LINEAGE; INFECTION;
MOSQUITOS; FLAVIVIRUSES
AB Background
Zika virus (ZIKV) has extended its known geographic distribution to the New World and is now responsible for severe clinical complications in a subset of patients. While substantial genetic and vector susceptibility data exist for ZIKV, less is known for the closest related flavivirus, Spondweni virus (SPONV). Both ZIKV and SPONV have been known to circulate in Africa since the mid-1900s, but neither has been genetically characterized by gene and compared in parallel. Furthermore, the susceptibility of peridomestic mosquito species incriminated or suspected in the transmission of ZIKV to SPONV was unknown.
Methodology/Principal Findings
In this study, two geographically distinct strains of SPONV were genetically characterized and compared to nine genetically and geographically distinct ZIKV strains. Additionally, the susceptibility of both SPONV strains was determined in three mosquito species. The open reading frame (ORF) of the SPONV 1952 Nigerian Chuku strain, exhibited a nucleotide and amino acid identity of 97.8% and 99.2%, respectively, when compared to the SPONV 1954 prototype South African SA Ar 94 strain. The ORF of the SPONV Chuku strain exhibited a nucleotide and amino acid identity that ranged from 68.3% to 69.0% and 74.6% to 75.0%, respectively, when compared to nine geographically and genetically distinct strains of ZIKV. The ORF of the nine African and Asian lineage ZIKV strains exhibited limited nucleotide divergence. Aedes aegypti, Ae. albopictus and Culex quinquefasciatus susceptibility and dissemination was low or non-existent following artificial infectious blood feeding of moderate doses of both SPONV strains.
Conclusions/Significance
SPONV and ZIKV nucleotide and amino acid divergence coupled with differences in geographic distribution, ecology and vector species support previous reports that these viruses are separate species. Furthermore, the low degree of SPONV infection or dissemination in Ae. albopictus, Ae. aegypti and Cx. quinquefasciatus following exposure to two geographically and genetically distinct virus strains suggest a low potential for these species to serve as vectors.
C1 [Haddow, Andrew D.; Nasar, Farooq; Guzman, Hilda; Tesh, Robert B.; Weaver, Scott C.] Univ Texas Med Branch, Dept Pathol, Inst Human Infect & Immun, Galveston, TX 77555 USA.
[Haddow, Andrew D.; Nasar, Farooq; Guzman, Hilda; Tesh, Robert B.; Weaver, Scott C.] Ctr Biodefense & Emerging Infect Dis, Galveston, TX 77555 USA.
[Haddow, Andrew D.; Nasar, Farooq] USAMRIID, Ft Detrick, MD 21702 USA.
[Ponlawat, Alongkot] Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok, Thailand.
[Jarman, Richard G.] AFRIMS, Dept Virol, Bangkok, Thailand.
[Weaver, Scott C.] Univ Texas Med Branch, Inst Human Infect & Immun, Dept Microbiol & Immunol, Galveston, TX 77555 USA.
RP Haddow, AD (reprint author), Univ Texas Med Branch, Dept Pathol, Inst Human Infect & Immun, Galveston, TX 77555 USA.; Haddow, AD (reprint author), Ctr Biodefense & Emerging Infect Dis, Galveston, TX 77555 USA.; Haddow, AD (reprint author), USAMRIID, Ft Detrick, MD 21702 USA.
EM andrew.d.haddow.ctr@mail.mil
FU NIH [AI069145, AI120942, N01-AI 30027]; DARPA; Robert E. Shope
International Fellowship in Infectious Diseases from the American
Society of Tropical Medicine and Hygiene; [A1007536]
FX This study was supported in part by NIH grants AI069145, AI120942, and
N01-AI 30027 (SCW and RBT). Additional funding was provided by DARPA
(ADH and FN). ADH was supported by T32 grant A1007536 and a Robert E.
Shope International Fellowship in Infectious Diseases from the American
Society of Tropical Medicine and Hygiene. The funders had no role in
study design, data collection and analysis, decision to publish, or
preparation of the manuscript.
NR 73
TC 0
Z9 0
U1 7
U2 7
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1935-2735
J9 PLOS NEGLECT TROP D
JI Plos Neglect. Trop. Dis.
PD OCT
PY 2016
VL 10
IS 10
AR e0005083
DI 10.1371/journal.pntd.0005083
PG 13
WC Infectious Diseases; Parasitology; Tropical Medicine
SC Infectious Diseases; Parasitology; Tropical Medicine
GA EA5QH
UT WOS:000386676200058
PM 27783682
ER
PT J
AU Ryan, ED
Shea, NW
Gerstner, GR
Barnette, TJ
Tweedell, AJ
Kleinberg, CR
AF Ryan, Eric D.
Shea, Nicholas W.
Gerstner, Gena R.
Barnette, Timothy J.
Tweedell, Andrew J.
Kleinberg, Craig R.
TI The influence of subcutaneous fat on the relationship between body
composition and ultrasound-derived muscle quality
SO APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
LA English
DT Article
DE echo intensity; intramuscular fat; obesity; adiposity; percent fat; limb
percent fat; musculoskeletal imaging
ID SKELETAL-MUSCLE; ECHO INTENSITY; MEDIAL GASTROCNEMIUS; SIZE; AGE;
RELIABILITY; RISK
AB Ultrasound echo intensity (EI) values are a popular assessment of muscle quality. The relationship between EI and total (% fat) and regional (% fat(limb)) body composition was examined in 40 men, prior to and after accounting for subcutaneous fat thickness. Uncorrected EI values suggest that muscle quality improves (r = -0.329 to -0.224; P = 0.038-0.165) with greater % fat and % fatlimb. However, corrected EI values indicated that muscle quality decreases (r = 0.711 to 0.798; P < 0.001) with greater % fat and % fat(limb).
C1 [Ryan, Eric D.; Shea, Nicholas W.; Gerstner, Gena R.; Barnette, Timothy J.; Tweedell, Andrew J.; Kleinberg, Craig R.] Univ N Carolina, Dept Exercise & Sports Sci, Neuromuscular Res Lab, Chapel Hill, NC 27599 USA.
[Ryan, Eric D.] Univ N Carolina, Allied Hlth Sci, Chapel Hill, NC 27599 USA.
[Ryan, Eric D.; Gerstner, Gena R.] Univ N Carolina, Human Movement Sci Curriculum, Chapel Hill, NC 27599 USA.
[Tweedell, Andrew J.] Army Res Lab, Aberdeen Proving Ground, MD USA.
RP Ryan, ED (reprint author), Univ N Carolina, Dept Exercise & Sports Sci, Neuromuscular Res Lab, Chapel Hill, NC 27599 USA.; Ryan, ED (reprint author), Univ N Carolina, Allied Hlth Sci, Chapel Hill, NC 27599 USA.; Ryan, ED (reprint author), Univ N Carolina, Human Movement Sci Curriculum, Chapel Hill, NC 27599 USA.
EM edryan@email.unc.edu
FU National Institute of Occupation Safety and Health [T42OH008673]
FX The authors thank Hayden Giuliani for her help with data collection.
This project was supported in part by a grant through the National
Institute of Occupation Safety and Health (T42OH008673).
NR 20
TC 0
Z9 0
U1 0
U2 0
PU CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 1715-5312
EI 1715-5320
J9 APPL PHYSIOL NUTR ME
JI Appl. Physiol. Nutr. Metab.
PD OCT
PY 2016
VL 41
IS 10
BP 1104
EP 1107
DI 10.1139/apnm-2016-0238
PG 4
WC Nutrition & Dietetics; Physiology; Sport Sciences
SC Nutrition & Dietetics; Physiology; Sport Sciences
GA DZ8NZ
UT WOS:000386128400016
ER
PT J
AU Por, ED
Choi, JH
Lund, BJ
AF Por, Elaine D.
Choi, Jae-Hyek
Lund, Brian J.
TI Low-Level Blast Exposure Increases Transient Receptor Potential
Vanilloid 1 (TRPV1) Expression in the Rat Cornea
SO CURRENT EYE RESEARCH
LA English
DT Article
DE Blast injury; cornea; inflammation; ocular trauma; pain
ID TRAUMATIC BRAIN-INJURY; TRIGEMINAL GANGLION NEURONS; INDUCED OCULAR
TRAUMA; CAPSAICIN RECEPTOR; MILITARY PERSONNEL; CHRONIC MIGRAINE; SPLICE
VARIANT; MOUSE MODEL; PAIN; RESPONSES
AB Background: Blast-related ocular injuries sustained by military personnel have led to rigorous efforts to elucidate the effects of blast exposure on neurosensory function. Recent studies have provided some insight into cognitive and visual deficits sustained following blast exposure; however, limited data are available on the effects of blast on pain and inflammatory processes. Investigation of these secondary effects of blast exposure is necessary to fully comprehend the complex pathophysiology of blast-related injuries. The overall purpose of this study is to determine the effects of single and repeated blast exposure on pain and inflammatory mediators in ocular tissues.Methods: A compressed air shock tube was used to deliver a single or repeated blast (68.0 2.7 kPa) to anesthetized rats daily for 5 days. Immunohistochemistry was performed on ocular tissues to determine the expression of the transient receptor potential vanilloid 1 (TRPV1) channel, calcitonin gene-related peptide (CGRP), substance P (SP), and endothelin-1 (ET-1) following single and repeated blast exposure. Neutrophil infiltration and myeloperoxidase (MPO) expression were also assessed in blast tissues via immunohistochemistry and enzyme-linked immunosorbent assay (ELISA) analysis, respectively.Results: TRPV1 expression was increased in rat corneas exposed to both single and repeated blast. Increased secretion of CGRP, SP, and ET-1 was also detected in rat corneas as compared to control. Moreover, repeated blast exposure resulted in neutrophil infiltration in the cornea and stromal layer as compared to control animals.Conclusion: Single and repeated blast exposure resulted in increased expression of TRPV1, CGRP, SP, and ET-1 as well as neutrophil infiltration. Collectively, these findings provide novel insight into the activation of pain and inflammation signaling mediators following blast exposure.
C1 [Por, Elaine D.; Choi, Jae-Hyek; Lund, Brian J.] US Army Inst Surg Res, Ocular Trauma, Jbsa Ft Sam Houston, TX USA.
RP Por, ED (reprint author), US Army Inst Surg Res, Ocular Trauma, 3698 Chambers Pass Ave,Bldg 3611, Ft Sam Houston, TX 78234 USA.
EM elaine.d.por.mil@mail.mil
FU U.S. Army Military Operational Medicine Research Program (MOMRP);
Clinical Rehabilitative Medicine Research Program (CRMRP)
FX This work was supported by U.S. Army Military Operational Medicine
Research Program (MOMRP) and Clinical Rehabilitative Medicine Research
Program (CRMRP).
NR 50
TC 0
Z9 0
U1 2
U2 2
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0271-3683
EI 1460-2202
J9 CURR EYE RES
JI Curr. Eye Res.
PD OCT
PY 2016
VL 41
IS 10
BP 1294
EP 1301
DI 10.3109/02713683.2015.1122812
PG 8
WC Ophthalmology
SC Ophthalmology
GA EA1DF
UT WOS:000386332000006
PM 27049881
ER
PT J
AU Pinti, M
Appay, V
Campisi, J
Frasca, D
Fulop, T
Sauce, D
Larbi, A
Weinberger, B
Cossarizza, A
AF Pinti, Marcello
Appay, Victor
Campisi, Judith
Frasca, Daniela
Fulop, Tamas
Sauce, Delphine
Larbi, Anis
Weinberger, Birgit
Cossarizza, Andrea
TI Aging of the immune system: Focus on inflammation and vaccination
SO EUROPEAN JOURNAL OF IMMUNOLOGY
LA English
DT Review
DE Aging; B lymphocytes; Longevity; NK cells; Signaling; T lymphocytes;
Vaccine
ID CD8(+) T-CELLS; NECROSIS-FACTOR-ALPHA; NATURAL-KILLER-CELLS;
AGE-RELATED-CHANGES; HUMAN CYTOMEGALOVIRUS-INFECTION; B-CELL; INFLUENZA
VACCINE; DENDRITIC CELLS; OLDER-ADULTS; NK CELLS
AB Major advances in preventing, delaying, or curing individual pathologies are responsible for an increasingly long life span in the developed parts of our planet, and indeed reaching eight to nine decades of life is nowadays extremely frequent. However, medical and sanitary advances have not prevented or delayed the underlying cause of the disparate pathologies occurring in the elderly: aging itself. The identification of the basis of the aging processes that drives the multiple pathologies and loss of function typical of older individuals is a major challenge in current aging research. Among the possible causes, an impairment of the immune system plays a major role, and indeed numerous studies have described immunological changes which occur with age. Far from the intention of being exhaustive, this review will focus on recent advances and views on the role that modifications of cell signalling and remodelling of the immune response play during human aging and longevity, paying particular attention to phenomena which are linked to the so called inflammaging process, such as dysregulation of innate immunity, altered T-cell or B-cell maturation and differentiation, as well as to the implications of immune aging for vaccination strategies in the elderly.
C1 [Pinti, Marcello] Univ Modena & Reggio Emilia, Dept Life Sci, Modena, Italy.
[Appay, Victor; Sauce, Delphine] Univ Paris 06, DHU FAST, Sorbonne Univ, CR7,Ctr Immunol & Malad Infect CIMI Paris, Paris, France.
[Campisi, Judith] USA, Berkeley, CA USA.
[Campisi, Judith] Lawrence Berkeley Natl Lab, Buck Inst Res Aging, Berkeley, CA USA.
[Frasca, Daniela] Univ Miami, Miller Sch Med, Dept Microbiol & Immunol, Miami, FL 33136 USA.
[Fulop, Tamas] Univ Sherbrooke, Res Ctr Aging, Dept Med, Div Geriatr, Sherbrooke, PQ J1K 2R1, Canada.
[Larbi, Anis] ASTAR, Aging & Immun Program, Singapore Immunol Network SIgN, Singapore, Singapore.
[Weinberger, Birgit] Univ Innsbruck, Inst Biomed Aging Res, Innsbruck, Austria.
[Cossarizza, Andrea] Univ Modena & Reggio Emilia, Sch Med, Dept Surg Med Dent & Morphol Sci, Modena, Italy.
RP Cossarizza, A (reprint author), Univ Modena & Reggio Emilia, Sch Med, Dept Surg Med Dent & Morphol Sci, Modena, Italy.
EM andrea.cossarizza@unimore.it
FU Fondazione Cassa di Risparmio di Vignola (Italy); French Agence
Nationale de la Recherche (ANR) [ANR-14-CE14-0030-01]; Fondation
Recherche Medicale [DEQ20120323690]; NIH [R21 AI096446, R21 AG042826,
R56 AG032576]; Canadian Institutes of Health Research (CIHR) [106634,
106701]; Universite de Sherbrooke; Research Center on Aging; SIgN;
Agency for Science Technology and Research (JCO DP) [1434m00115, SRIS
SRG/14018]; European Union [280873 ADITEC]; Ministero dell'Istruzione,
Universita, Ricerca (MIUR) [RBAP11S8C3]
FX M.P. is supported by Fondazione Cassa di Risparmio di Vignola (Italy);
V.A. and D.S. are supported by the French Agence Nationale de la
Recherche (ANR; project ANR-14-CE14-0030-01) and the Fondation Recherche
Medicale (project DEQ20120323690); D.F. is supported by NIH grants R21
AI096446, R21 AG042826, and R56 AG032576; T.F. has received grants from
by the Canadian Institutes of Health Research (CIHR) (No. 106634 and
106701), the Universite de Sherbrooke, and the Research Center on Aging;
A.L. is supported by SIgN and the Agency for Science Technology and
Research (JCO DP # 1434m00115 and SRIS SRG/14018); B.W. has received
funding from the European Union's Seventh Framework Programme
[FP7/2007-2013] under Grant Agreement No: 280873 ADITEC; A.C. has been
supported by Ministero dell'Istruzione, Universita, Ricerca (MIUR grant
RBAP11S8C3).
NR 180
TC 2
Z9 2
U1 10
U2 10
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0014-2980
EI 1521-4141
J9 EUR J IMMUNOL
JI Eur. J. Immunol.
PD OCT
PY 2016
VL 46
IS 10
BP 2286
EP 2301
DI 10.1002/eji.201546178
PG 16
WC Immunology
SC Immunology
GA DZ9VV
UT WOS:000386229600002
PM 27595500
ER
PT J
AU Torrieri, D
Talarico, S
Valenti, MC
AF Torrieri, Don
Talarico, Salvatore
Valenti, Matthew C.
TI Analysis of a Frequency-Hopping Millimeter-Wave Cellular Uplink
SO IEEE TRANSACTIONS ON WIRELESS COMMUNICATIONS
LA English
DT Article; Proceedings Paper
CT 34th IEEE Annual Military Communications Conference (MILCOM) on
Leveraging Technology - The Joint Imperative
CY OCT 26-28, 2015
CL Tampa, FL
SP IEEE
DE Millimeter-wave cellular networks; frequency hopping; antenna
directivity; stochastic geometry
ID NETWORKS; TUTORIAL; COVERAGE; LTE; 5G
AB Fifth-generation (5G) cellular networks are expected to exhibit at least three primary physical-layer differences relative to fourth-generation (4G) ones: millimeter-wave propagation, massive antenna arrays, and densification of base stations. As in 4G systems, such as LTE, 5G systems are likely to continue to use single-carrier frequency-division multiple-access on the uplink due to its advantageous peak-to-average power ratio. Moreover, 5G systems are likely to use frequency hopping on the uplink to help randomize interference and provide diversity against frequency-selective fading. In this paper, the implications of these and other physical-layer features on uplink performance are assessed using a novel millimeter-wave propagation model featuring distance-dependent parameters that characterize the path-loss, shadowing, and fading. The analysis proceeds by first fixing the location of the mobile devices and finding the performance conditioned on the topology. The spatially averaged performance is then found by averaging with respect to the location of the mobile devices. The analysis allows for the use of actual base-station topologies and the propagation model can leverage empirical millimeter-wave measurements. The benefits of base-station densification, highly directional sectorization, frequency hopping, a large available bandwidth, and a high code rate are illustrated. The minor importance of fractional power control is shown.
C1 [Torrieri, Don] US Army, Res Lab, Adelphi, MA 20783 USA.
[Talarico, Salvatore; Valenti, Matthew C.] West Virginia Univ, Morgantown, WV 26506 USA.
[Talarico, Salvatore] Huawei Technol Inc, Santa Clara, CA 95050 USA.
RP Talarico, S (reprint author), Huawei Technol Inc, Santa Clara, CA 95050 USA.
EM vrt01@verizon.net; salvatore.talarico81@gmail.com; valenti@ieee.org
OI Valenti, Matthew/0000-0001-6089-0509
NR 23
TC 0
Z9 0
U1 3
U2 3
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 1536-1276
EI 1558-2248
J9 IEEE T WIREL COMMUN
JI IEEE Trans. Wirel. Commun.
PD OCT
PY 2016
VL 15
IS 10
BP 7089
EP 7098
DI 10.1109/TWC.2016.2597210
PG 10
WC Engineering, Electrical & Electronic; Telecommunications
SC Engineering; Telecommunications
GA DZ7TE
UT WOS:000386068800042
ER
PT J
AU Mendoza, PA
Mizukami, N
Ikeda, K
Clark, MP
Gutmann, ED
Arnold, JR
Brekke, LD
Rajagopalan, B
AF Mendoza, Pablo A.
Mizukami, Naoki
Ikeda, Kyoko
Clark, Martyn P.
Gutmann, Ethan D.
Arnold, Jeffrey R.
Brekke, Levi D.
Rajagopalan, Balaji
TI Effects of different regional climate model resolution and forcing
scales on projected hydrologic changes
SO JOURNAL OF HYDROLOGY
LA English
DT Article
DE Climate change; Regional climate model; Spatial aggregation; Horizontal
resolution; Hydrologic model structure
ID GENERAL-CIRCULATION MODELS; CONTERMINOUS UNITED-STATES; COLORADO
RIVER-BASIN; SELF-ORGANIZING MAPS; LAND-SURFACE FLUXES; CHANGE IMPACTS;
CATCHMENT CLASSIFICATION; SPATIAL VARIABILITY; WINTER PRECIPITATION;
ENSEMBLE APPROACH
AB We examine the effects of regional climate model (RCM) horizontal resolution and forcing scaling (i.e., spatial aggregation of meteorological datasets) on the portrayal of climate change impacts. Specifically, we assess how the above decisions affect: (i) historical simulation of signature measures of hydrologic behavior, and (ii) projected changes in terms of annual water balance and hydrologic signature measures. To this end, we conduct our study in three catchments located in the headwaters of the Colorado River basin. Meteorological forcings for current and a future climate projection are obtained at three spatial resolutions (4-, 12- and 36-km) from dynamical downscaling with the Weather Research and Forecasting (WRF) regional climate model, and hydrologic changes are computed using four different hydrologic model structures. These projected changes are compared to those obtained from running hydrologic simulations with current and future 4-km WRF climate outputs re-scaled to 12- and 36-km. The results show that the horizontal resolution of WRF simulations heavily affects basin-averaged precipitation amounts, propagating into large differences in simulated signature measures across model structures. The implications of re-scaled forcing datasets on historical performance were primarily observed on simulated runoff seasonality. We also found that the effects of WRF grid resolution on projected changes in mean annual runoff and evapotranspiration may be larger than the effects of hydrologic model choice, which surpasses the effects from re-scaled forcings. Scaling effects on projected variations in hydrologic signature measures were found to be generally smaller than those coming from WRF resolution; however, forcing aggregation in many cases reversed the direction of projected changes in hydrologic behavior. (C) 2016 Elsevier B.V. All rights reserved.
C1 [Mendoza, Pablo A.; Rajagopalan, Balaji] Univ Colorado Boulder, Dept Civil Environm & Architectural Engn, Boulder, CO USA.
[Mendoza, Pablo A.; Rajagopalan, Balaji] Univ Colorado Boulder, Cooperat Inst Res Environm Sci, Boulder, CO USA.
[Mendoza, Pablo A.; Mizukami, Naoki; Ikeda, Kyoko; Clark, Martyn P.; Gutmann, Ethan D.] Natl Ctr Atmospher Res, Hydrometeorol Applicat Program, POB 3000, Boulder, CO 80307 USA.
[Arnold, Jeffrey R.] US Army, Corps Engineers, Climate Preparedness & Resilience Programs, Seattle, WA USA.
[Brekke, Levi D.] Bur Reclamat, Denver, CO USA.
RP Mendoza, PA (reprint author), Natl Ctr Atmospher Res, Res Applicat Lab, POB 3000, Boulder, CO 80307 USA.
EM pmendoza@ucar.edu
OI Ikeda, Kyoko/0000-0002-3952-8019
FU U.S. Army Corps of Engineers; U.S. Bureau Of Reclamation; U.S. Army
Corps of Engineers through Cooperative Institute for Research and
Environmental Sciences (CIRES); National Science Foundation
FX We thank Marketa Elsner, Andy Newman, Michael Barlage, Roland Viger,
Adam Carheden and Tor Mohling for their feedback and assistance for
setting up the models. This work was supported through a contract with
the U.S. Army Corps of Engineers, through a Cooperative Agreement with
the U.S. Bureau Of Reclamation, and through a graduate fellowship from
the Cooperative Institute for Research and Environmental Sciences
(CIRES). The National Center for Atmospheric Research is sponsored by
the National Science Foundation. Finally, we thank two anonymous
reviewers for their highly constructive comments, which contributed to
improve this manuscript considerably.
NR 119
TC 0
Z9 0
U1 5
U2 5
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0022-1694
EI 1879-2707
J9 J HYDROL
JI J. Hydrol.
PD OCT
PY 2016
VL 541
BP 1003
EP 1019
DI 10.1016/j.jhydrol.2016.08.010
PN B
PG 17
WC Engineering, Civil; Geosciences, Multidisciplinary; Water Resources
SC Engineering; Geology; Water Resources
GA EA2GI
UT WOS:000386410400028
ER
PT J
AU Barry, BE
Roberts, MW
AF Barry, Brock E.
Roberts, Matthew W.
TI First 60 Years of the Journal of Professional Issues in Engineering
Education and Practice
SO JOURNAL OF PROFESSIONAL ISSUES IN ENGINEERING EDUCATION AND PRACTICE
LA English
DT Article
DE ASCE journal; Publication; Scholarship; History
AB The ASCEs' Journal of Professional Issues in Engineering Education and Practice has reached 60years of publication. Taking a detailed look at the content and authorship during that time period provides insights into the journal's history and its progression. The authors of this article employed qualitative and quantitative investigation techniques to answer the single research question: How has the journal changed since its inception? Data were collected via semistructured interviews, database assimilation, and the review and evaluation of 1,573 articles. Findings generated during this study address publication rates, citation rates, article subject area trends, keyword usage, author affiliations, impact factor rankings, international collaborations, and scholarship standards. A significant number of conclusions are offered, but the primary conclusion is that the journal has increased its publication of high-quality scholarly research.
C1 [Barry, Brock E.] US Mil Acad, Dept Civil & Mech Engn, West Point, NY 10996 USA.
[Roberts, Matthew W.] Southern Utah Univ, Dept Engn & Technol, Cedar City, UT 84720 USA.
RP Barry, BE (reprint author), US Mil Acad, Dept Civil & Mech Engn, West Point, NY 10996 USA.
EM brock.barry@usma.edu
NR 19
TC 0
Z9 0
U1 7
U2 7
PU ASCE-AMER SOC CIVIL ENGINEERS
PI RESTON
PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA
SN 1052-3928
EI 1943-5541
J9 J PROF ISS ENG ED PR
JI J. Prof. Issues Eng. Educ. Pract.
PD OCT
PY 2016
VL 142
IS 4
AR 03116001
DI 10.1061/(ASCE)EI.1943-5541.0000277
PG 14
WC Education, Scientific Disciplines; Engineering, Multidisciplinary
SC Education & Educational Research; Engineering
GA DX3XN
UT WOS:000384310900001
ER
PT J
AU Nishimoto, P
Morrison, P
Medina-Dupaix, C
Kim, J
Chock, M
Bantum, E
AF Nishimoto, Patricia
Morrison, Penny
Medina-Dupaix, Carolina
Kim, John
Chock, Marci
Bantum, Erin
TI Perceived Impact of Participation in a One-Time Expressive Arts Workshop
SO PSYCHO-ONCOLOGY
LA English
DT Meeting Abstract
C1 [Nishimoto, Patricia] Tripler Army Med Ctr, Dept Med, Honolulu, HI 96859 USA.
[Morrison, Penny] Univ Hawaii Manoa, Sch Nursing & Dent Hyg, Honolulu, HI 96822 USA.
[Medina-Dupaix, Carolina] State Hawaii Off Vet Serv, Honolulu, HI USA.
[Kim, John] Tripler Army Med Ctr, Dept Behav Hlth, Honolulu, HI 96859 USA.
[Chock, Marci] Univ Hawaii Manoa, John A Burns Sch Med, Honolulu, HI 96822 USA.
[Bantum, Erin] Univ Hawaii, Canc Res Ctr, Div Canc Prevent & Control Program, Honolulu, HI 96813 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1057-9249
EI 1099-1611
J9 PSYCHO-ONCOLOGY
JI Psycho-Oncol.
PD OCT
PY 2016
VL 25
IS SP. S3
MA 42
BP 14
EP 14
PG 1
WC Oncology; Psychology; Psychology, Multidisciplinary; Social Sciences,
Biomedical
SC Oncology; Psychology; Biomedical Social Sciences
GA DZ6AA
UT WOS:000385942700030
ER
PT J
AU Ganesan, R
Jajodia, S
Shah, A
Cam, H
AF Ganesan, Rajesh
Jajodia, Sushil
Shah, Ankit
Cam, Hasan
TI Dynamic Scheduling of Cybersecurity Analysts for Minimizing Risk Using
Reinforcement Learning
SO ACM TRANSACTIONS ON INTELLIGENT SYSTEMS AND TECHNOLOGY
LA English
DT Article
DE Cybersecurity; Analysts; Dynamic Scheduling; Cybersecurity analysts;
dynamic scheduling; genetic algorithm; integer programming;
optimization; reinforcement learning; resource allocation; risk
mitigation
ID TIME
AB An important component of the cyber-defense mechanism is the adequate staffing levels of its cybersecurity analyst workforce and their optimal assignment to sensors for investigating the dynamic alert traffic. The ever-increasing cybersecurity threats faced by today's digital systems require a strong cyber-defense mechanism that is both reactive in its response to mitigate the known risk and proactive in being prepared for handling the unknown risks. In order to be proactive for handling the unknown risks, the above workforce must be scheduled dynamically so the system is adaptive to meet the day-to-day stochastic demands on its workforce (both size and expertise mix). The stochastic demands on the workforce stem from the varying alert generation and their significance rate, which causes an uncertainty for the cybersecurity analyst scheduler that is attempting to schedule analysts for work and allocate sensors to analysts. Sensor data are analyzed by automatic processing systems, and alerts are generated. A portion of these alerts is categorized to be significant, which requires thorough examination by a cybersecurity analyst. Risk, in this article, is defined as the percentage of significant alerts that are not thoroughly analyzed by analysts. In order to minimize risk, it is imperative that the cyber-defense system accurately estimates the future significant alert generation rate and dynamically schedules its workforce to meet the stochastic workload demand to analyze them. The article presents a reinforcement learning-based stochastic dynamic programming optimization model that incorporates the above estimates of future alert rates and responds by dynamically scheduling cybersecurity analysts to minimize risk (i.e., maximize significant alert coverage by analysts) and maintain the risk under a pre-determined upper bound. The article tests the dynamic optimization model and compares the results to an integer programming model that optimizes the static staffing needs based on a daily-average alert generation rate with no estimation of future alert rates (static workforce model). Results indicate that over a finite planning horizon, the learning-based optimization model, through a dynamic (on-call) workforce in addition to the static workforce, (a) is capable of balancing risk between days and reducing overall risk better than the static model, (b) is scalable and capable of identifying the quantity and the right mix of analyst expertise in an organization, and (c) is able to determine their dynamic (on-call) schedule and their sensor-to-analyst allocation in order to maintain risk below a given upper bound. Several meta-principles are presented, which are derived from the optimization model, and they further serve as guiding principles for hiring and scheduling cybersecurity analysts. Days-off scheduling was performed to determine analyst weekly work schedules that met the cybersecurity system's workforce constraints and requirements.
C1 [Ganesan, Rajesh] George Mason Univ, Dept Syst Engn & Operat Res, Mail Stop 4A6, Fairfax, VA 22030 USA.
[Jajodia, Sushil; Shah, Ankit] George Mason Univ, Ctr Secure Informat Syst, Mail Stop 5B5, Fairfax, VA 22030 USA.
[Cam, Hasan] Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
RP Ganesan, R (reprint author), George Mason Univ, Dept Syst Engn & Operat Res, Mail Stop 4A6, Fairfax, VA 22030 USA.
EM rganesan@gmu.edu; jajodia@gmu.edu; ashah20@gmu.edu;
hasan.cam.civ@mail.mil
FU Army Research Office [W911NF-13-1-0421, W911NF-13-1-0317]; Office of
Naval Research [N00014-15-1-2007, N00014-13-1-0703]
FX R. Ganesan, S. Jajodia, and A. Shah were partially supported by the Army
Research Office under Grants No. W911NF-13-1-0421 and No.
W911NF-13-1-0317 and by the Office of Naval Research under Grants No.
N00014-15-1-2007 and No. N00014-13-1-0703.
NR 31
TC 0
Z9 0
U1 5
U2 5
PU ASSOC COMPUTING MACHINERY
PI NEW YORK
PA 2 PENN PLAZA, STE 701, NEW YORK, NY 10121-0701 USA
SN 2157-6904
EI 2157-6912
J9 ACM T INTEL SYST TEC
JI ACM Trans. Intell. Syst. Technol.
PD OCT
PY 2016
VL 8
IS 1
AR 4
DI 10.1145/2882969
PG 21
WC Computer Science, Artificial Intelligence; Computer Science, Information
Systems
SC Computer Science
GA DZ1SW
UT WOS:000385621300004
ER
PT J
AU Zurawski, DV
Lee, RE
AF Zurawski, Daniel V.
Lee, Richard E.
TI A Tribute to Amy Anderson (1969-2016): Leader, Role Model, and Advocate
for Structure-Based Design of New Antimicrobial Agents
SO ACS INFECTIOUS DISEASES
LA English
DT Editorial Material
ID TRIMETHOPRIM-RESISTANT; AUREUS
C1 [Zurawski, Daniel V.] Walter Reed Army Inst Res, Bacterial Dis Branch, Wound Infect Dept, Silver Spring, MD 20910 USA.
[Lee, Richard E.] St Jude Childrens Res Hosp, Dept Chem Biol & Therapeut, Memphis, TN 38105 USA.
RP Zurawski, DV (reprint author), Walter Reed Army Inst Res Bacterial Dis, Wound Infect Dept, Room 3A45,2460 Linden Lane,Bldg 503, Silver Spring, MD 20910 USA.
EM daniel.v.zurawski.ctr@mail.mil
RI Zurawski, Daniel/B-6578-2009
OI Zurawski, Daniel/0000-0002-7920-5601
NR 6
TC 0
Z9 0
U1 0
U2 0
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 2373-8227
J9 ACS INFECT DIS
JI ACS Infect. Dis.
PD OCT
PY 2016
VL 2
IS 10
BP 664
EP 665
DI 10.1021/acsinfecdis.6b00156
PG 2
WC Chemistry, Medicinal; Infectious Diseases
SC Pharmacology & Pharmacy; Infectious Diseases
GA DZ2TE
UT WOS:000385693700001
PM 27737556
ER
PT J
AU Gupta, N
Suhre, DR
AF Gupta, Neelam
Suhre, Dennis R.
TI Notch filtering using a multiple passband AOTF in the SWIR region
SO APPLIED OPTICS
LA English
DT Article
ID ACOUSTOOPTIC TUNABLE FILTER; TELECENTRIC CONFOCAL OPTICS;
SPECTROPOLARIMETRIC IMAGER; SPATIAL-RESOLUTION; SINGLE-CRYSTAL;
PERFORMANCE; ULTRAVIOLET; TEO2; SPECTROMETER; HG2CL2
AB A notch filtering operation was accomplished using a TeO2 acousto-optic tunable filter (AOTF) with 16 simultaneous overlapping passbands in the shortwave infrared wavelength region. By switching off specific radio frequency signals applied to the AOTF, laser wavelengths corresponding to the inactive passbands are rejected, providing see-through capability with the remaining wavelengths. The rejection level was determined by leakage through the sidelobes of adjacent passbands, as was shown by theory and corresponding measurements. By switching off multiple passbands near the laser wavelength, the rejection level can be increased at the expense of reduced see-through capability. The AOTF imaging system used telecentric confocal optics that compensate for AOTF aberrations, which are severe at high sidelobe operation. (C) 2016 Optical Society of America
C1 [Gupta, Neelam] US Army, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
[Suhre, Dennis R.] DRS Sci Inc, 300 Oaklake Rd, New Kensington, PA 15068 USA.
RP Gupta, N (reprint author), US Army, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM neelam.gupta.civ@mail.mil
NR 47
TC 0
Z9 0
U1 12
U2 12
PU OPTICAL SOC AMER
PI WASHINGTON
PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA
SN 1559-128X
EI 2155-3165
J9 APPL OPTICS
JI Appl. Optics
PD OCT 1
PY 2016
VL 55
IS 28
BP 7855
EP 7860
DI 10.1364/AO.55.007855
PG 6
WC Optics
SC Optics
GA DZ3AJ
UT WOS:000385715100015
PM 27828017
ER
PT J
AU Haddow, AD
Woodall, JP
AF Haddow, Andrew D.
Woodall, John P.
TI Distinguishing between Zika and Spondweni viruses
SO BULLETIN OF THE WORLD HEALTH ORGANIZATION
LA English
DT Editorial Material
C1 [Haddow, Andrew D.] US Army, Med Res Inst Infect Dis, Dept Entomol, Ft Detrick, MD 21702 USA.
[Woodall, John P.] ProMED Mail, Int Soc Infect Dis, Brookline, MA USA.
RP Haddow, AD (reprint author), US Army, Med Res Inst Infect Dis, Dept Entomol, Ft Detrick, MD 21702 USA.
EM andrew.d.haddow.ctr@mail.mil
NR 0
TC 1
Z9 1
U1 4
U2 4
PU WORLD HEALTH ORGANIZATION
PI GENEVA 27
PA MARKETING AND DISSEMINATION, CH-1211 GENEVA 27, SWITZERLAND
SN 0042-9686
EI 1564-0604
J9 B WORLD HEALTH ORGAN
JI Bull. World Health Organ.
PD OCT
PY 2016
VL 94
IS 10
BP 711
EP 711
DI 10.2471/BLT.16.181503
PG 1
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA DZ5OY
UT WOS:000385912600002
PM 27843157
ER
PT J
AU Jugg, BJA
Hoard-Fruchey, H
Rothwell, C
Dillman, JF
David, J
Jennerr, J
Sciuto, AM
AF Jugg, Bronwen J. A.
Hoard-Fruchey, Heidi
Rothwell, Cristin
Dillman, James F.
David, Jonathan
Jennerr, John
Sciuto, Alfred M.
TI Acute Gene Expression Profile of Lung Tissue Following Sulfur Mustard
Inhalation Exposure in Large Anesthetized Swine
SO CHEMICAL RESEARCH IN TOXICOLOGY
LA English
DT Article
ID PLASMINOGEN-ACTIVATOR INHIBITOR-1; PULMONARY-FUNCTION TEST; INFLAMMATORY
RESPONSE; DEPENDENT PATHWAY; HUMAN-LYMPHOCYTES; N-ACETYLCYSTEINE; GAS
WORKERS; INJURY; KERATINOCYTES; APOPTOSIS
AB Sulfur mustard (HD) is a vesicating and alkylating agent widely used on the battlefield during World War I and more recently in the Iran-Iraq War. It targets the eyes, skin, and lungs, producing skin burns, conjunctivitis, and compromised respiratory function; early acute effects lead to long-term consequences. However, it is the effects on the lungs that drive morbidity and eventual mortality. The temporal postexposure response to HD within lung tissue raises the question of whether toxicity is driven by the alkylating properties of HD on critical homeostatic pathways. We have established an anesthetized swine model of inhaled HD vapor exposure to investigate the toxic effects of HD 12 h postexposure. Large white female swine were anesthetized and instrumented prior to exposure to air, 60 (sublethal) or 100 mu g.kg(-1) (similar to LD40) doses of HD (10 min). Physiological parameters were continuously assessed. Data indicate that exposure to 100 mu g.kg(-1) HD lowered arterial blood oxygenation and increased shunt fraction and lavage protein compared with those of air-exposed controls and the 60 mu g.kg(-1) dose of HD. Histopathology showed an increased total pathology score between the 100 mu g.kg(-1) HD group and air-exposed controls. Principal component analysis of differentially expressed genes demonstrated a distinct and separable response of inhaled HD between air-exposed controls and the 60 and 100 mu g.kg(-1) doses of HD. Canonical pathway analysis demonstrated changes in acute phase response signaling, aryl hydrocarbon receptor signaling, NRF-2 mediated oxidative stress, and zymosterol biosynthesis in the 60 and 100 mu g.kg(-1) HD dose group. Transcriptional changes also indicated alterations in immune response, cancer, and cell signaling and metabolism canonical pathways. The 100 mu g.kg(-1) dose group also showed significant changes in cholesterol biosynthesis. Taken together, exposure to inhaled HD had a significant effect on physiological responses coinciding with acute changes in gene expression and lung histopathology. In addition, transcriptomics support the observed beneficial effects of N-acetyl-L-cysteine for treatment of acute inhalation HD exposure.
C1 [Jugg, Bronwen J. A.; David, Jonathan; Jennerr, John] Dstl Porton Down, CBR Div, Salisbury SP4 0JQ, Wilts, England.
[Hoard-Fruchey, Heidi; Rothwell, Cristin; Dillman, James F.; Sciuto, Alfred M.] US Army, Med Res Inst Chem Def, 2900 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA.
RP Hoard-Fruchey, H (reprint author), US Army, Med Res Inst Chem Def, 2900 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA.
EM heidi.m.hoard-fruchey.civ@mail.mil
FU Defense Threat Reduction Agency (US Department of Defense) [HDTRA
1-07-C-0027, W81XWH-09-C-0083, RESP.CBM.01.10.RC.009]
FX This work was supported by the Defense Threat Reduction Agency (US
Department of Defense) under Contracts HDTRA 1-07-C-0027 and
W81XWH-09-C-0083 in support of RESP.CBM.01.10.RC.009.
NR 50
TC 0
Z9 0
U1 2
U2 2
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0893-228X
EI 1520-5010
J9 CHEM RES TOXICOL
JI Chem. Res. Toxicol.
PD OCT
PY 2016
VL 29
IS 10
BP 1602
EP 1610
DI 10.1021/acs.chemrestox.6b00069
PG 9
WC Chemistry, Medicinal; Chemistry, Multidisciplinary; Toxicology
SC Pharmacology & Pharmacy; Chemistry; Toxicology
GA DZ3YK
UT WOS:000385785600004
PM 27617619
ER
PT J
AU AbdulHameed, MDM
Ippolito, DL
Wallqvist, A
AF AbdulHameed, Mohamed Diwan M.
Ippolito, Danielle L.
Wallqvist, Anders
TI Predicting Rat and Human Pregnane X Receptor Activators Using Bayesian
Classification Models
SO CHEMICAL RESEARCH IN TOXICOLOGY
LA English
DT Article
ID DRUG DISCOVERY; ENVIRONMENTAL CHEMICALS; XENOBIOTIC METABOLISM; ADMET
EVALUATION; PXR; TOXICITY; IDENTIFICATION; CONSEQUENCES; INDUCTION;
DATASETS
AB The pregnane X receptor (PXR) is a ligand-activated transcription factor that acts as a master regulator of metabolizing enzymes and transporters. To avoid adverse drug drug interactions and diseases such as steatosis and cancers associated with PXR activation, identifying drugs and chemicals that activate PXR is of crucial importance. In this work, we developed ligand-based predictive computational models for both rat and human PXR activation, which allowed us to identify potentially harmful chemicals and evaluate species-specific effects of a given compound. We utilized a large publicly available data set of nearly 2000 compounds screened in cell-based reporter gene assays to develop Bayesian quantitative structure activity relationship models using physicochemical properties and structural descriptors. Our analysis showed that PXR activators tend to be hydrophobic and significantly different from nonactivators in terms of their physicochemical properties such as molecular weight, logP, number of rings, and solubility. Our Bayesian models, evaluated by using 5-fold cross-validation, displayed a sensitivity of 75% (76%), specificity of 76% (75%), and accuracy of 89% (89%) for human (rat) PXR activation. We identified structural features shared by rat and human PXR activators as well as those unique to each species. We compared rat in vitro PXR activation data to in vivo data by using DrugMatrix, a large toxicogenomics database with gene expression data obtained from rats after exposure to diverse chemicals. Although in vivo gene expression data pointed to cross-talk between nuclear receptor activators that is captured only by in vivo assays, overall we found broad agreement between in vitro and in vivo PXR activation. Thus, the models developed here serve primarily as efficient initial high-throughput in silico screens of in vitro activity.
C1 [AbdulHameed, Mohamed Diwan M.; Wallqvist, Anders] US Army Med Res & Mat Command, Biotechnol High Performance Comp Software Applica, Telemed & Adv Technol Res Ctr, Dept Def, 504 Scott St, Ft Detrick, MD 21702 USA.
[Ippolito, Danielle L.] US Army Ctr Environm Hlth Res, 568 Doughten Dr, Ft Detrick, MD 21702 USA.
RP AbdulHameed, MDM; Wallqvist, A (reprint author), US Army Med Res & Mat Command, Biotechnol High Performance Comp Software Applica, Telemed & Adv Technol Res Ctr, Dept Def, 504 Scott St, Ft Detrick, MD 21702 USA.
EM mabdulhameed@bhsai.org; sven.a.wallqvist.civ@mail.mil
FU Military Operational Medicine Research Program; U.S. Army's Network
Science Initiative, U.S. Army Medical Research and Materiel Command
(USAMRMC), Ft. Detrick, MD
FX The authors were supported by the Military Operational Medicine Research
Program and the U.S. Army's Network Science Initiative, U.S. Army
Medical Research and Materiel Command (USAMRMC,
http://mrmc.amedd.army.mil), Ft. Detrick, MD.
NR 56
TC 1
Z9 1
U1 1
U2 1
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0893-228X
EI 1520-5010
J9 CHEM RES TOXICOL
JI Chem. Res. Toxicol.
PD OCT
PY 2016
VL 29
IS 10
BP 1729
EP 1740
DI 10.1021/acs.chemrestox.6b00227
PG 12
WC Chemistry, Medicinal; Chemistry, Multidisciplinary; Toxicology
SC Pharmacology & Pharmacy; Chemistry; Toxicology
GA DZ3YK
UT WOS:000385785600015
PM 27603675
ER
PT J
AU Legree, PJ
Mullins, HM
Psotka, J
AF Legree, Peter J.
Mullins, Heather M.
Psotka, Joseph
TI Comment: The Ability Model of Emotional Intelligence: Consistency With
Intelligence Theory
SO EMOTION REVIEW
LA English
DT Editorial Material
DE profile similarity metrics
AB Mayer, Caruso, and Salovey (2016) provide useful updates to the EI ability model and related concepts. However, they do not acknowledge conceptual limitations with the MSCEIT proportion scoring algorithm. In our view, failure to recognize these limitations has impeded refinements to the EI ability model and delayed support for positioning EI within the Cattelt-Horn-Carroll (CHC) three-stratum theory of intelligence (Carroll, 1993). Fully appreciating algorithm-related issues justifies the reanalysis of MSCEIT data and may expand the range of metrics that are available to refine EI theory.
C1 [Legree, Peter J.; Psotka, Joseph] US Army Res Inst Behav & Social Sci, 6000 6th St,Bldg 1464,Mail Stop 5610, Ft Belvoir, VA 22026 USA.
[Mullins, Heather M.] George Mason Univ, Fairfax, VA 22030 USA.
RP Legree, PJ (reprint author), US Army Res Inst Behav & Social Sci, 6000 6th St,Bldg 1464,Mail Stop 5610, Ft Belvoir, VA 22026 USA.
EM Peter.J.Legree.Civ@Mail.Mil
NR 6
TC 1
Z9 1
U1 2
U2 2
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1754-0739
EI 1754-0747
J9 EMOT REV
JI Emot. Rev.
PD OCT
PY 2016
VL 8
IS 4
BP 301
EP 302
DI 10.1177/1754073916650500
PG 2
WC Psychology, Multidisciplinary
SC Psychology
GA DY7SS
UT WOS:000385330200003
ER
PT J
AU Manners, JL
Forsten, RD
Kotwal, RS
Elbin, RJ
Collins, MW
Kontos, AP
AF Manners, Jody L.
Forsten, Robert D.
Kotwal, Russ S.
Elbin, R. J.
Collins, Michael W.
Kontos, Anthony P.
TI Role of Pre-Morbid Factors and Exposure to Blast Mild Traumatic Brain
Injury on Post-Traumatic Stress in United States Military Personnel
SO JOURNAL OF NEUROTRAUMA
LA English
DT Article
DE blast; concussion; mTBI; PTSD
ID PERSISTENT POSTCONCUSSIVE SYMPTOMS; COGNITIVE SEQUELAE; SERVICE MEMBERS;
CONCUSSION; DISORDER; ASSOCIATION; OUTCOMES; IRAQ; CONSEQUENCES;
AFGHANISTAN
AB Mild traumatic brain injury (mTBI), the signature injury of the recent wars in Afghanistan and Iraq, is a prevalent and potentially debilitating condition that is associated with symptoms of post-traumatic stress/post-traumatic stress disorder (PTS/PTSD). Prior mTBI, severity and type of injury (blast vs. non-blast), and baseline psychiatric illness are thought to impact mTBI outcomes. It is unclear if the severity of pre-morbid PTS/PTSD is a risk factor of post-injury levels of PTS and mTBI symptoms. The objective of the study was to examine predictors of post-injury PTS/PTSD, including premorbid PTS symptoms, and physical and cognitive symptoms in the sub-acute phase (1 week-3 months) following an acute mTBI. A retrospective review of medical records was performed of 276 servicemen assigned to the United States Army Special Operations Command referred for mTBI evaluation between December 2009 and March 2011. Post-Concussion Symptom Scale and PTSD Checklist scores were captured pre-and post-injury. A total of 276 records were reviewed. Pre-morbid and post-injury data were available for 91% (251/276). Of the 54% (136/251) of personnel with mTBI, 29% (39/136) had positive radiology findings and 11% (15/136) met criteria for clinical PTS symptoms at baseline. Logistic regression analysis found baseline PTS symptoms predicted personnel who met clinical levels of PTSD. Receiver operating characteristic curve analysis revealed that baseline PTS (p = 0.001), baseline mTBI symptoms (p = 0.001), and positive radiology (magnetic resonance imaging or computed tomography) findings for complicated mTBI (p = 0.02) accurately identified personnel with clinical levels of PTSD following mTBI. Years of military service, combat deployment status, age, and injury mechanism (blast vs. non-blast) were not associated with increased risk of PTS following mTBI. Pre-morbid PTS symptoms are associated with an increased risk for clinical levels of PTS following a subsequent mTBI. Symptom severity and positive radiologic findings may amplify this risk. At-risk personnel may benefit from early identification and intervention.
C1 [Manners, Jody L.] Univ Pittsburgh, Sch Med, Dept Neurol, Pittsburgh, PA 15261 USA.
[Kontos, Anthony P.] Univ Pittsburgh, Sch Med, Dept Orthoped Surg, Pittsburgh, PA USA.
[Forsten, Robert D.] US Army War Coll, Carlisle, PA USA.
[Kotwal, Russ S.] US Army Inst Surg Res, Joint Trauma Syst, San Antonio, TX USA.
[Elbin, R. J.; Collins, Michael W.] Univ Arkansas, Off Sport Concuss Res, Fayetteville, AR 72701 USA.
RP Kontos, AP (reprint author), UPMC, Ctr Sports Med, 3200 South Water St, Pittsburgh, PA 15203 USA.
EM akontos@pitt.edu
NR 36
TC 0
Z9 0
U1 4
U2 4
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0897-7151
EI 1557-9042
J9 J NEUROTRAUM
JI J. Neurotrauma
PD OCT 1
PY 2016
VL 33
IS 19
BP 1796
EP 1801
DI 10.1089/neu.2015.4245
PG 6
WC Critical Care Medicine; Clinical Neurology; Neurosciences
SC General & Internal Medicine; Neurosciences & Neurology
GA DY8KP
UT WOS:000385379100009
PM 27027526
ER
PT J
AU Rupprecht, EA
Kueny, CR
Shoss, MK
Metzger, AJ
AF Rupprecht, Elizabeth A.
Kueny, Clair Reynolds
Shoss, Mindy K.
Metzger, Andrew J.
TI Getting What You Want: How Fit Between Desired and Received Leader
Sensitivity Influences Emotion and Counterproductive Work Behavior
SO JOURNAL OF OCCUPATIONAL HEALTH PSYCHOLOGY
LA English
DT Article
DE sensitivity; stressor-emotion model; implicit leadership theory;
counterproductive work behavior
ID PERCEIVED SUPERVISOR SUPPORT; AMAZON MECHANICAL TURK; PERSON-ENVIRONMENT
FIT; WORKPLACE BEHAVIOR; ORGANIZATIONAL RESEARCH; INITIATING STRUCTURE;
IMPLICIT LEADERSHIP; ABUSIVE SUPERVISION; EMPLOYEE OUTCOMES; MODERATING
ROLE
AB We challenge the intuitive belief that greater leader sensitivity is always associated with desirable outcomes for employees and organizations. Specifically, we argue that followers' idiosyncratic desires for, and perceptions of, leader sensitivity behaviors play a key role in how followers react to their leader's sensitivity. Moreover, these resulting affective experiences are likely to have important consequences for organizations, specifically as they relate to employee counterproductive work behavior (CWB). Drawing from supplies-values (S-V) fit theory and the stressor-emotion model of CWB, the current study focuses on the affective and behavioral consequences of fit between subordinates' ideal leader sensitivity behavior preferences and subordinates' perceptions of their actual leader's sensitivity behaviors. Polynomial regression analyses reveal that congruence between ideal and actual leader sensitivity influences employee negative affect and, consequently, engagement in counterproductive work behavior.
C1 [Rupprecht, Elizabeth A.] US Army, Res Inst, 6000 6th St Bldg 1464, Ft Belvoir, VA 22060 USA.
[Kueny, Clair Reynolds; Metzger, Andrew J.] St Louis Univ, Dept Psychol, St Louis, MO 63103 USA.
[Shoss, Mindy K.] Univ Cent Florida, Dept Psychol, Orlando, FL 32816 USA.
RP Rupprecht, EA (reprint author), US Army, Res Inst, 6000 6th St Bldg 1464, Ft Belvoir, VA 22060 USA.
EM earupprecht@gmail.com
NR 81
TC 0
Z9 0
U1 20
U2 20
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 1076-8998
EI 1939-1307
J9 J OCCUP HEALTH PSYCH
JI J. Occup. Health Psychol.
PD OCT
PY 2016
VL 21
IS 4
BP 443
EP 454
DI 10.1037/a0040074
PG 12
WC Public, Environmental & Occupational Health; Psychology, Applied
SC Public, Environmental & Occupational Health; Psychology
GA DZ1FD
UT WOS:000385583400006
PM 26784688
ER
PT J
AU Keasey, SL
Natesan, M
Pugh, C
Kamata, T
Wuchty, S
Ulrich, RG
AF Keasey, Sarah L.
Natesan, Mohan
Pugh, Christine
Kamata, Teddy
Wuchty, Stefan
Ulrich, Robert G.
TI Cell-free Determination of Binary Complexes That Comprise Extended
Protein-Protein Interaction Networks of Yersinia pestis
SO MOLECULAR & CELLULAR PROTEOMICS
LA English
DT Article
ID TANDEM AFFINITY PURIFICATION; RNA CHAPERONE HFQ; ESCHERICHIA-COLI;
HELICOBACTER-PYLORI; INTERACTION MAP; III SECRETION; IN-VITRO;
PSEUDOTUBERCULOSIS; INHIBITORS; BIOLOGY
AB Binary protein interactions form the basic building blocks of molecular networks and dynamic assemblies that control all cellular functions of bacteria. Although these protein interactions are a potential source of targets for the development of new antibiotics, few high-confidence data sets are available for the large proteomes of most pathogenic bacteria. We used a library of recombinant proteins from the plague bacterium Yersinia pestis to probe planar microarrays of immobilized proteins that represented similar to 85% (3552 proteins) of the bacterial proteome, resulting in >77,000 experimentally determined binary interactions. Moderate (K-D similar to mu M) to high-affinity (K-D similar to nM) interactions were characterized for >1600 binary complexes by surface plasmon resonance imaging of microarrayed proteins. Core binary interactions that were in common with other gram-negative bacteria were identified from the results of both microarray methods. Clustering of proteins within the interaction network by function revealed statistically enriched complexes and pathways involved in replication, biosynthesis, virulence, metabolism, and other diverse biological processes. The interaction pathways included many proteins with no previously known function. Further, a large assembly of proteins linked to transcription and translation were contained within highly interconnected subregions of the network. The two-tiered microarray approach used here is an innovative method for detecting binary interactions, and the resulting data will serve as a critical resource for the analysis of protein interaction networks that function within an important human pathogen.
C1 [Keasey, Sarah L.; Natesan, Mohan; Pugh, Christine; Kamata, Teddy; Ulrich, Robert G.] US Army Med Res Inst Infect Dis, Mol & Translat Sci Div, Frederick, MD 21702 USA.
[Keasey, Sarah L.] Univ Maryland Baltimore Cty, Dept Biol Sci, Baltimore, MD 21250 USA.
[Wuchty, Stefan] NIH, Natl Ctr Biotechnol Informat, Bldg 10, Bethesda, MD 20892 USA.
[Wuchty, Stefan] Univ Miami, Dept Comp Sci, Coral Gables, FL 33124 USA.
RP Ulrich, RG (reprint author), USAMRIID, Mol & Translat Sci, 1425 Porter St, Frederick, MD 21702 USA.
EM rulrich@bhsai.org
FU Defense Threat Reduction Agency (RGU)
FX This work was supported in part by a grant from the Defense Threat
Reduction Agency (RGU) and by appointment of SLK to the Research
Participation Program for the U.S. Army Medical Research and Materiel
Command, administered through an agreement between the U.S. Department
of Energy and the USAMRMC. Opinions, interpretations, conclusions, and
recommendations are those of the authors and are not necessarily
endorsed by the U.S. Army or the National Institutes of Health.
10.1074/mcp.M116.059337.
NR 51
TC 0
Z9 0
U1 3
U2 3
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA
SN 1535-9476
EI 1535-9484
J9 MOL CELL PROTEOMICS
JI Mol. Cell. Proteomics
PD OCT
PY 2016
VL 15
IS 10
BP 3220
EP 3232
DI 10.1074/mcp.M116.059337
PG 13
WC Biochemical Research Methods
SC Biochemistry & Molecular Biology
GA DY8JB
UT WOS:000385374800010
PM 27489291
ER
PT J
AU Wu, ZZ
Ji, SP
Liu, TC
Duan, YD
Xiao, S
Lin, Y
Xu, K
Pan, F
AF Wu, Zhongzhen
Ji, Shunping
Liu, Tongchao
Duan, Yandong
Xiao, Shu
Lin, Yuan
Xu, Kang
Pan, Feng
TI Aligned Li+ Tunnels in Core Shell Li(NixMnyCoz)O-2@LiFePO4 Enhances Its
High Voltage Cycling Stability as Li-ion Battery Cathode
SO NANO LETTERS
LA English
DT Article
DE Li(Ni0.5Mn0.3Co0.2)O-2; nano-LiFePO4; aligned Li+ tunnels; core-shell
coating
ID ELECTROCHEMICAL PROPERTIES; THERMAL-STABILITY; LITHIUM BATTERIES;
HIGH-CAPACITY; RECHARGEABLE BATTERIES; RATE CAPABILITY; PERFORMANCE;
LAYER; LINI0.5CO0.2MN0.3O2; IMPROVEMENT
AB Layered transition-metal oxides (Li[NixMnyCoz]O-2, NMC, or NMCxyz) due to their poor stability when cycled at a high operating voltage (>4.5 V) have limited their practical applications in industry. Earlier researches have identified Mn(II)-dissolution and some parasitic reactions between NMC surface and electrolyte, especially when NMC is charged to a high potential, as primarily factors responsible for the fading. In our previous work, we have achieved a capacity of NMC active material close to theoretical value and optimized its cycling performance by a depolarized carbon nanotubes (CNTs) network and an unique "pre-lithiation process" that generates an in situ organic coating (similar to 40 nm) to prevent Mn(II) dissolution and minimize the parasitic reactions. Unfortunately, this organic coating is not durable enough during a long-term cycling when the cathode operates at a high potential (>4.5 V). This work attempts to improve the surface protection of the NMC532 particles by applying an active inorganic coating consisting of nanosized- and crystal-orientated LiFePO4 (LFP) (about 50 nm, exposed (010) face) to generate a core-shell nanostructure of Li(NixMnyCoz)O-2@LiFePO4. Transmission electron microscopy (TEM) and etching X-ray photoelectron spectroscopy have confirmed an intimate contact coating (about 50 nm) between the original structure of NMC and LFP single-particle with atomic interdiffusion at the core-shell interface, and an array of interconnected aligned Li+ tunnels are observed at the interface by cross-sectional high-resolution TEM, which were formed by ball-milling and then strictly controlling the temperature below 100 degrees C. Batteries based on this modified NMC cathode material show a high reversible capacity when cycled between 3.0 and 4.6 V during a long-term cycling.
C1 [Wu, Zhongzhen; Ji, Shunping; Liu, Tongchao; Duan, Yandong; Xiao, Shu; Lin, Yuan; Pan, Feng] Peking Univ, Sch Adv Mat, Shenzhen Grad Sch, Shenzhen 518055, Peoples R China.
[Xu, Kang] US Army, Res Lab, Adelphi, MD 20783 USA.
RP Pan, F (reprint author), Peking Univ, Sch Adv Mat, Shenzhen Grad Sch, Shenzhen 518055, Peoples R China.
EM panfeng@pkusz.edu.cn
RI Duan, Yandong/I-4206-2013; lin, yuan/G-9390-2013
OI lin, yuan/0000-0003-3410-3588
FU National Science Foundation of China [51301004]; Guangdong Innovation
Team Project [2013N080]; Shenzhen Science and Technology Research Grant
[JCYJ20140903102215536, JCYJ20150828093127698, CXZZ20120829172325895,
KYPT20141016105435850]
FX This work was financially supported jointly by National Science
Foundation of China (51301004), Guangdong Innovation Team Project
(2013N080) and Shenzhen Science and Technology Research Grant
(JCYJ20140903102215536, JCYJ20150828093127698, CXZZ20120829172325895,
peacock plan KYPT20141016105435850).
NR 42
TC 4
Z9 4
U1 67
U2 67
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1530-6984
EI 1530-6992
J9 NANO LETT
JI Nano Lett.
PD OCT
PY 2016
VL 16
IS 10
BP 6357
EP 6363
DI 10.1021/acs.nanolett.6b02742
PG 7
WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience &
Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied;
Physics, Condensed Matter
SC Chemistry; Science & Technology - Other Topics; Materials Science;
Physics
GA DY9QI
UT WOS:000385469800053
PM 27588693
ER
PT J
AU Fleischman, ZD
Sanamyan, T
AF Fleischman, Zackery D.
Sanamyan, Tigran
TI Spectroscopic analysis of Er3+:Y2O3 relevant to 2.7 mu m mid-IR laser
SO OPTICAL MATERIALS EXPRESS
LA English
DT Article
ID MU-M; EMISSION; CW
AB The spectroscopic properties of ceramic Er3+:Y2O3 relevant to the 2.7 mu m mid-IR laser transition were studied in the temperature range of 77-300K. We present the results of experimental measurements of absorption and fluorescence which were used to determine the branching ratios and fluorescence quantum efficiency of the I-4(11/2) upper laser level. We have shown that the quantum yield of the mid-IR transition more than doubles when the sample is cooled from room to cryogenic temperature, and the stimulated emission cross-section of the highest peak increases by a factor of 10 for the same temperature change. Updated cryogenic Er3+: Y2O3 laser parameters for the mid-IR similar to 2.7um transition are presented as well. (C) 2016 Optical Society of America
C1 [Fleischman, Zackery D.; Sanamyan, Tigran] US Army, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
RP Fleischman, ZD (reprint author), US Army, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM zackery.d.fleischman.civ@mail.mil
NR 17
TC 0
Z9 0
U1 5
U2 5
PU OPTICAL SOC AMER
PI WASHINGTON
PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA
SN 2159-3930
J9 OPT MATER EXPRESS
JI Opt. Mater. Express
PD OCT 1
PY 2016
VL 6
IS 10
BP 3109
EP 3118
DI 10.1364/OME.6.003109
PG 10
WC Materials Science, Multidisciplinary; Optics
SC Materials Science; Optics
GA DY8WD
UT WOS:000385411600007
ER
PT J
AU Stith, SM
Milner, JS
Fleming, M
Robichaux, RJ
Travis, WJ
AF Stith, Sandra M.
Milner, Joel S.
Fleming, Matthew
Robichaux, Rene J.
Travis, Wendy J.
TI Intimate Partner Physical Injury Risk Assessment in a Military Sample
SO PSYCHOLOGY OF VIOLENCE
LA English
DT Article
DE risk assessment; intimate partner violence; physical injury; domestic
violence; military
ID PREDICTIVE-VALIDITY; VIOLENCE; RECIDIVISM; INFERENCE; ABUSE
AB Objectives: This paper describes the development of an actuarial risk assessment instrument (the Intimate Partner Physical Injury-Risk Assessment Tool; IPPI-RAT) designed to be used by military providers to assess the likelihood that an individual who has had an alleged incident of intimate partner violence (IPV) will have a subsequent incident resulting in a physical injury to the victim. Method: Providers used a 58-item structured risk assessment tool to assess individuals with alleged IPV incidents (N = 199). Across a 6-month period, alleged victims were asked to call an automated telephone system to report subsequent incidents of IPV and physical injury (N = 1,082 calls). An item analysis was used to select the items that significantly differentiated the "physical injury" group from the "other" group (i.e., comparison group). Results: Fifteen items from the 58-item tool significantly predicted future physical injury and were used to create a 15-item IPPI-RAT scale. The area under the curve (Area Under the Receiver Operator Curve, AUC) value for the tool was .78, 95% CI [.71, .86]. This AUC value indicates there is a 78% chance that a randomly selected member of the physical injury group would have a higher risk score than a randomly selected member of the "other" (i.e., comparison) group. Conclusions: Findings support the tool's utility for assessing risk for future physical injury as part of a comprehensive IPV risk assessment in reported IPV incidents in the military.
C1 [Stith, Sandra M.] Kansas State Univ, Sch Family Studies & Human Serv, 101 Campus Creek Complex, Manhattan, KS 66506 USA.
[Milner, Joel S.; Fleming, Matthew] Northern Illinois Univ, Ctr Study Family Violence & Sexual Assault, Dept Psychol, De Kalb, IL 60115 USA.
[Robichaux, Rene J.] US Army Med Command, Behav Hlth Div, San Antonio, TX USA.
[Travis, Wendy J.] US Air Force, Div Mental Hlth, Washington, DC USA.
[Travis, Wendy J.] US Air Force Acad, Colorado Springs, CO USA.
RP Stith, SM (reprint author), Kansas State Univ, Sch Family Studies & Human Serv, 101 Campus Creek Complex, Manhattan, KS 66506 USA.
EM sstith@ksu.edu
FU United States Department of Agriculture: National Institute of Food and
Agriculture; United States Army; United States Air Force; Department of
Defense
FX The first two authors of this paper acknowledge funding from the United
States Department of Agriculture: National Institute of Food and
Agriculture, United States Army, United States Air Force, and the
Department of Defense in support of this project, and the guidance of
many military colleagues who have provided leadership support for this
project including: David Lloyd, JD, and Katherine Robertson, MSW, Office
of Secretary of Defense, Family Advocacy Program, Carla Monroe-Posey,
PhD, Pamela S. Collins, MSW, and Maureen Simmons, MSW, United States Air
Force Family Advocacy Program. The views expressed herein are those of
the authors and do not reflect the official policy or position of Brooke
Army Medical Center, the U.S. Army Medical Department, the U.S. Army
Office of the Surgeon General, the U.S. Air Force Academy, the U.S. Air
Force, the Department of Defense, or the U.S. Government.
NR 28
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U1 2
U2 2
PU EDUCATIONAL PUBLISHING FOUNDATION-AMERICAN PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST, NE, WASHINGTON, DC 20002-4242 USA
SN 2152-0828
EI 2152-081X
J9 PSYCHOL VIOLENCE
JI Psychol. Violence
PD OCT
PY 2016
VL 6
IS 4
BP 529
EP 541
DI 10.1037/a0039969
PG 13
WC Psychology, Clinical; Criminology & Penology; Family Studies
SC Psychology; Criminology & Penology; Family Studies
GA DZ5PV
UT WOS:000385914900005
ER
PT J
AU Gosch, NJC
Miller, ML
Gemeinhardt, TR
Starks, TA
Civiello, AP
Long, JM
Bonneau, JL
AF Gosch, N. J. C.
Miller, M. L.
Gemeinhardt, T. R.
Starks, T. A.
Civiello, A. P.
Long, J. M.
Bonneau, J. L.
TI Age-0 Shovelnose Sturgeon Prey Consumption in the Lower Missouri River
SO RIVER RESEARCH AND APPLICATIONS
LA English
DT Article
DE shovelnose sturgeon; diet; Missouri River; pallid sturgeon
ID SCAPHIRHYNCHUS SPP.; DIET COMPOSITION; PALLID STURGEON; GROWTH; LARVAL;
FOOD
AB A lack of nutritious food during the first year of life is a hypothesized factor that may limit survival of endangered pallid sturgeon Scaphirhynchus albus in the lower Missouri River (LMOR). Unfortunately, information for age-0 pallid sturgeon diets remains limited, but diet analyses for age-0 Scaphirhynchus spp. (sturgeon hereafter) have occurred. Little information, however, exists on age-0 sturgeon diets in the LMOR; thus, our primary objective was to document age-0 sturgeon diets in this system. We examined guts contents from 30 individuals, which were genetically identified as shovelnose sturgeon Scaphirhynchus platorynchus, and three stomachs were empty. The remaining age-0 shovelnose sturgeon consumed chironomid larvae almost exclusively (>98% of prey items consumed). Our results were similar to studies conducted in other systems, and it appears unlikely that a lack of nutritious food was a major factor affecting the individuals captured during this study. This effort provides important information to help guide ongoing adaptive management efforts in the LMOR. (c) 2016 The Authors. River Research and Applications published by John Wiley & Sons Ltd.
C1 [Gosch, N. J. C.; Miller, M. L.; Gemeinhardt, T. R.] US Army Corps Engineers, Kansas City, MO 64106 USA.
[Starks, T. A.; Civiello, A. P.] Oklahoma State Univ, Dept Nat Resources Ecol & Management, Stillwater, OK 74078 USA.
[Long, J. M.] Oklahoma State Univ, US Geol Survey, Oklahoma Cooperat Fish & Wildlife Res Unit, Dept Nat Resources Ecol & Management, Stillwater, OK 74078 USA.
[Bonneau, J. L.] US Army Corps Engineers, Yankton, SD USA.
RP Gosch, NJC (reprint author), US Army Corps Engineers, Kansas City, MO 64106 USA.
EM Nathan.J.Gosch@usace.army.mil
FU U.S. Army Corps of Engineers Kansas City District through United States
Geological Survey [G12AC20430]; U.S. Geological Survey; Oklahoma State
University; Oklahoma Department of Wildlife Conservation; Wildlife
Management Institute; U.S. Fish and Wildlife Service
FX Steven Chipps provided valuable comments on an earlier draft of this
manuscript. We thank Kevin Montemayor as well as numerous other U.S.
Army Corps of Engineers staff for field assistance. This study was
funded by the U.S. Army Corps of Engineers Kansas City District through
the United States Geological Survey (Cooperative Agreement Number
G12AC20430). The Oklahoma Cooperative Fish and Wildlife Research Unit is
jointly supported by the U.S. Geological Survey, Oklahoma State
University, the Oklahoma Department of Wildlife Conservation, the
Wildlife Management Institute and the U.S. Fish and Wildlife Service.
The contents of this report are not to be used for advertising,
publication, or promotional purposes. Reference to trade names does not
imply endorsement by the U.S. Government. All product names and
trademarks cited are the property of their respective owners. The
findings of this report are not to be construed as an official
Department of Army position unless so designated by other authorized
documents.
NR 14
TC 0
Z9 0
U1 2
U2 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1535-1459
EI 1535-1467
J9 RIVER RES APPL
JI River Res. Appl.
PD OCT
PY 2016
VL 32
IS 8
BP 1819
EP 1823
DI 10.1002/rra.3003
PG 5
WC Environmental Sciences; Water Resources
SC Environmental Sciences & Ecology; Water Resources
GA DY9CW
UT WOS:000385431600014
ER
PT J
AU Martini, W
AF Martini, Wenjun
TI EXPERIMENTALLY APPROACHING THE TRAUMA-INDUCED COAGULOPATHY
SO SHOCK
LA English
DT Meeting Abstract
CT 8th Congress of the International-Federation-of-Shock-Societies
CY OCT 03-05, 2016
CL Tokyo, JAPAN
SP Int Federat Shock Soc
C1 [Martini, Wenjun] US Army, Inst Surg Res, Hemostasis Damage Control Resuscitat, Ft Sam Houston, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1073-2322
EI 1540-0514
J9 SHOCK
JI Shock
PD OCT
PY 2016
VL 46
IS 4
SU 2
MA SY2-6
BP 11
EP 11
PG 1
WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease
SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System
& Cardiology
GA DX3GY
UT WOS:000384262800015
ER
PT J
AU Cao, ZH
Cai, HQ
AF Cao, Zuohao
Cai, Huaqing
TI Identification of forcing mechanisms of convective initiation over
mountains through high-resolution numerical simulations
SO ADVANCES IN ATMOSPHERIC SCIENCES
LA English
DT Editorial Material
ID STORM INITIATION; EVOLUTION; RAINFALL; FREQUENCY; IHOP-2002; FORECASTS;
ONTARIO; DRYLINE; IHOP
C1 [Cao, Zuohao] Environm & Climate Change Canada, Toronto, ON, Canada.
[Cai, Huaqing] US Army Res Lab, White Sands Missile Range, NM USA.
RP Cao, ZH (reprint author), Environm & Climate Change Canada, Toronto, ON, Canada.
EM zuohao.cao@canada.ca
NR 23
TC 1
Z9 1
U1 6
U2 6
PU SCIENCE PRESS
PI BEIJING
PA 16 DONGHUANGCHENGGEN NORTH ST, BEIJING 100717, PEOPLES R CHINA
SN 0256-1530
EI 1861-9533
J9 ADV ATMOS SCI
JI Adv. Atmos. Sci.
PD OCT
PY 2016
VL 33
IS 10
SI SI
BP 1104
EP 1105
DI 10.1007/s00376-016-6198-4
PG 2
WC Meteorology & Atmospheric Sciences
SC Meteorology & Atmospheric Sciences
GA DY5JY
UT WOS:000385137100003
ER
PT J
AU Lim, JW
AF Lim, J. W.
TI Consideration of structural constraints in passive rotor blade design
for improved performance
SO AERONAUTICAL JOURNAL
LA English
DT Article
DE Passive Rotor Blade Design; Performance; Structural Constraints;
Optimisation; Aerodynamics; Aircraft Design; Flight simulation;
Performance; Rotorcraft
ID OPTIMIZATION
AB This design study applied parameterisation to rotor blade for improved performance. In the design, parametric equations were used to represent blade planform changes over the existing rotor blade model. Design variables included blade twist, sweep, dihedral and the radial control point. Updates to the blade structural properties with changes in the design variables allowed accurate evaluation of performance objectives and realistic structural constraints - blade stability, steady moments (flap bending, chord bending and torsion) and the high-g manoeuvre pitch link loads. Performance improvement was demonstrated with multiple parametric designs. Using a parametric design with advanced aerofoils, the predicted power reduction was 1.0% in hover, 10.0% at mu = 0.30 and 17.0% at mu = 0.40, relative to the baseline UH-60A rotor, but these were obtained with a 35% increase in the steady chord bending moment at mu = 0.30 and a 20% increase in the half peak-to-peak pitch link load during the UH-60A UTTAS manoeuvre. Low vibration was maintained for this design. More rigorous design efforts, such as chord tapering and/or structural redesign of the blade cross section, would enlarge the feasible design space and likely provide significant performance improvement.
C1 [Lim, J. W.] US Army, Aviat Dev Directorate AFDD, Aviat & Missile Res Dev & Engn Ctr, Res Dev & Engn Command RDECOM,Ames Res Ctr, Moffett Field, CA 94035 USA.
RP Lim, JW (reprint author), US Army, Aviat Dev Directorate AFDD, Aviat & Missile Res Dev & Engn Ctr, Res Dev & Engn Command RDECOM,Ames Res Ctr, Moffett Field, CA 94035 USA.
EM joon.w.lim.civ@mail.mil
NR 27
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Z9 0
U1 1
U2 1
PU ROYAL AERONAUTICAL SOC
PI LONDON
PA 4 HAMILTON PL, LONDON W1J 7BQ, ENGLAND
SN 0001-9240
J9 AERONAUT J
JI Aeronaut. J.
PD OCT
PY 2016
VL 120
IS 1232
BP 1604
EP 1631
DI 10.1017/aer.2016.77
PG 28
WC Engineering, Aerospace
SC Engineering
GA DY4GC
UT WOS:000385056000005
ER
PT J
AU Yoganandan, N
Chirvi, S
Pintar, FA
Uppal, H
Schlick, M
Banerjee, A
Voo, L
Merkle, A
Kleinberger, M
AF Yoganandan, Narayan
Chirvi, Sajal
Pintar, Frank A.
Uppal, Harmeeth
Schlick, Michael
Banerjee, Anjishnu
Voo, Liming
Merkle, Andrew
Kleinberger, Michael
TI Foot-Ankle Fractures and Injury Probability Curves from Post-mortem
Human Surrogate Tests
SO ANNALS OF BIOMEDICAL ENGINEERING
LA English
DT Article
DE Calcaneus fractures; Biomechanics; Risk curves; Tibia fractures;
Military injuries; Survival analysis; Weibull distribution
ID OPERATION IRAQI FREEDOM; MOTOR-VEHICLE CRASHES; HUMAN SUBJECT TESTS;
EXTREMITY INJURIES; COMPLEX; TRAUMA
AB This purpose of this study was to replicate foot-ankle injuries seen in the military and derive human injury probability curves using the human cadaver model. Lower legs were isolated below knee from seventeen unembalmed human cadavers and they were aligned in a 90-90 posture (plantar surface orthogonal to leg). The specimens were loaded along the tibia axis by applying short-time duration pulses, using a repeated testing protocol. Injuries were documented using pre- and post-test X-rays, computed tomography scans, and dissection. Peak force-based risk curves were derived using survival analysis and accounted for data censoring. Fractures were grouped into all foot-ankle (A), any calcaneus (B), and any tibia injuries (C), respectively. Calcaneus and/or distal tibia/pilon fractures occurred in fourteen tests. Axial forces were the greatest and least for groups C and B, respectively. Times attainments of forces for all groups were within ten milliseconds. The Weibull function was the optimal probability distribution for all groups. Age was significant (p < 0.05) for groups A and C. Survival analysis-based probability curves were derived for all groups. Data are given in the body of paper. Age-based, risk-specific, and continuous distribution probability curves/responses guide in the creation of an injury assessment capability for military blast environments.
C1 [Yoganandan, Narayan; Uppal, Harmeeth] Med Coll Wisconsin, Dept Orthopaed Surg, 9200 West Wisconsin Ave, Milwaukee, WI 53226 USA.
[Yoganandan, Narayan; Chirvi, Sajal; Pintar, Frank A.; Schlick, Michael] Med Coll Wisconsin, Dept Neurosurg, 9200 West Wisconsin Ave, Milwaukee, WI 53226 USA.
[Banerjee, Anjishnu] Med Coll Wisconsin, Div Biostat, 9200 West Wisconsin Ave, Milwaukee, WI 53226 USA.
[Voo, Liming; Merkle, Andrew] Johns Hopkins Univ, Appl Phys Lab, Laurel, MD USA.
[Kleinberger, Michael] US Army, Res Lab, Aberdeen Proving Ground, MD USA.
RP Yoganandan, N (reprint author), Med Coll Wisconsin, Dept Neurosurg, 9200 West Wisconsin Ave, Milwaukee, WI 53226 USA.
EM yoga@mcw.edu
FU Department of Veterans Affairs Medical Research [W81XWH-10-2-0065,
W81XWH-12-0041]; Department of Neurosurgery at the Medical College of
Wisconsin [W81XWH-10-2-0065, W81XWH-12-0041]
FX This research was supported in part by the Cooperative Agreements
W81XWH-10-2-0065 and W81XWH-12-0041 (Warrior Injury Assessment Manikin
study), Department of Veterans Affairs Medical Research and Department
of Neurosurgery at the Medical College of Wisconsin. This material is
the result of work supported with resources and use of facilities at the
Zablocki VA Medical Center, Milwaukee, Wisconsin and Medical College of
Wisconsin. The first, second, fourth and fifth authors are part-time
employees of the Zablocki VA Medical Center, Milwaukee, Wisconsin. Any
views expressed in this article are those of the authors and not
necessarily representative of the funding organizations. Further, all
authors do not have any sources of conflict of interest for this work.
NR 41
TC 0
Z9 0
U1 7
U2 7
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0090-6964
EI 1573-9686
J9 ANN BIOMED ENG
JI Ann. Biomed. Eng.
PD OCT
PY 2016
VL 44
IS 10
BP 2937
EP 2947
DI 10.1007/s10439-016-1598-2
PG 11
WC Engineering, Biomedical
SC Engineering
GA DY5SC
UT WOS:000385161800008
PM 27052746
ER
PT J
AU Moon, SY
Proussaloglou, E
Peterson, GW
DeCoste, JB
Hall, MG
Howarth, AJ
Hupp, JT
Farha, OK
AF Moon, Su-Young
Proussaloglou, Emmanuel
Peterson, Gregory W.
DeCoste, Jared B.
Hall, Morgan G.
Howarth, Ashlee J.
Hupp, Joseph T.
Farha, Omar K.
TI Detoxification of Chemical Warfare Agents Using a Zr-6-Based
Metal-Organic Framework/Polymer Mixture
SO CHEMISTRY-A EUROPEAN JOURNAL
LA English
DT Article
DE heterogeneous buffer; heterogeneous catalysis; hydrolysis; nerve agents;
zirconium MOF
ID NERVE AGENTS; VX; DESTRUCTION; HYDROLYSIS; DEGRADATION; SIMULANTS; HD;
PARAOXON; GD; POLYMERS
AB Owing to their high surface area, periodic distribution of metal sites, and water stability, zirconium-based metal-organic frameworks (Zr-6-MOFs) have shown promising activity for the hydrolysis of nerve agents GD and VX, as well as the simulant, dimethyl 4-nitrophenylphosphate (DMNP), in buffered solutions. A hurdle to using MOFs for this application is the current need for a buffer solution. Here the destruction of the simulant DMNP, as well as the chemical warfare agents (GD and VX) through hydrolysis using a MOF catalyst mixed with a non-volatile, water-insoluble, heterogeneous buffer is reported. The hydrolysis of the simulant and nerve agents in the presence of the heterogeneous buffer was fast and effective.
C1 [Moon, Su-Young; Proussaloglou, Emmanuel; Howarth, Ashlee J.; Hupp, Joseph T.; Farha, Omar K.] Northwestern Univ, Dept Chem, 2145 Sheridan Rd, Evanston, IL 60208 USA.
[Peterson, Gregory W.; DeCoste, Jared B.; Hall, Morgan G.] US Army, Edgewood Chem Biol Ctr, Res Dev & Engn Command, 5183 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA.
[Farha, Omar K.] King Abdulaziz Univ, Fac Sci, Dept Chem, Jeddah, Saudi Arabia.
RP Hupp, JT; Farha, OK (reprint author), Northwestern Univ, Dept Chem, 2145 Sheridan Rd, Evanston, IL 60208 USA.; Farha, OK (reprint author), King Abdulaziz Univ, Fac Sci, Dept Chem, Jeddah, Saudi Arabia.
EM j-hupp@northwestern.edu; o-farha@northwestern.edu
RI Faculty of, Sciences, KAU/E-7305-2017
FU Army Research Office [W911NF-13-1-0229]; MRSEC program of the National
Science Foundation at the Materials Research Center of Northwestern
University [DMR-1121262]; Defense Threat Reduction Agency [BA07PRO104,
BA13PHM210]
FX O.K.F. and J.T.H. acknowledge funding by the Army Research Office
(project no. W911NF-13-1-0229). This work made use of the J. B. Cohen
X-ray Diffraction Facility supported by the MRSEC program of the
National Science Foundation (DMR-1121262) at the Materials Research
Center of Northwestern University. G.W.P. and J.B.D. acknowledge funding
by the Defense Threat Reduction Agency (project Nos. BA07PRO104 and
BA13PHM210).
NR 39
TC 1
Z9 1
U1 47
U2 47
PU WILEY-V C H VERLAG GMBH
PI WEINHEIM
PA POSTFACH 101161, 69451 WEINHEIM, GERMANY
SN 0947-6539
EI 1521-3765
J9 CHEM-EUR J
JI Chem.-Eur. J.
PD OCT
PY 2016
VL 22
IS 42
BP 14864
EP 14868
DI 10.1002/chem.201603976
PG 5
WC Chemistry, Multidisciplinary
SC Chemistry
GA DY0SO
UT WOS:000384806700046
PM 27607019
ER
PT J
AU Sheehan, RC
Gottschall, JS
AF Sheehan, Riley C.
Gottschall, Jinger S.
TI Ramp Angle, Not Plateau Height, Influences Transition Strategies
SO JOURNAL OF APPLIED BIOMECHANICS
LA English
DT Article
DE walking; hill; electromyography; kinematics; kinetics
ID GEOGRAPHICAL SLANT; SLOPED SURFACES; LOCOMOTION; WALKING; VISION; STEP
AB In a previous study, we found that participants modified how they transitioned onto and off of ramp configurations depending upon the incline. While the transition strategies were originally attributed to ramp angles, it is possible that the plateau influenced the strategies since the final surface height also differed. Ultimately, for the current study, we hypothesized that an individual's transition strategies would have significant main effects for ramp angle, but not plateau height. Twelve healthy, young adults transitioned onto 3 distinct ramp configurations, a 2.4-m ramp angled at 12.5 degrees ending at a plateau height of 53 cm, a 1.2-m ramp angled at 23.5 degrees ending at a plateau height of 53 cm, and a 2.4-m ramp angled at 23.5 degrees ending at a plateau height of 99.5 cm. Kinematics, kinetics, and muscle activity were measured during the stance phase before contacting the ramp. In support of our hypothesis, impact peak, active peak, and all of the muscle activity variables had a significant main effect for ramp angle, with greater vertical force peaks and muscle activity on steeper ramp transitions. These findings support our previous interpretation that individuals use estimations of ramp angle, not plateau height, to determine their transition strategies.
C1 [Sheehan, Riley C.] Brooke Army Med Ctr, Mil Performance Lab, Ctr Intrepid, JBSA, Ft Sam Houston, TX 78234 USA.
[Gottschall, Jinger S.] Penn State Univ, Dept Kinesiol, University Pk, PA 16802 USA.
RP Sheehan, RC (reprint author), Brooke Army Med Ctr, Mil Performance Lab, Ctr Intrepid, JBSA, Ft Sam Houston, TX 78234 USA.
EM rileycsheehan@gmail.com
NR 15
TC 0
Z9 0
U1 0
U2 0
PU HUMAN KINETICS PUBL INC
PI CHAMPAIGN
PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA
SN 1065-8483
EI 1543-2688
J9 J APPL BIOMECH
JI J. Appl. Biomech.
PD OCT
PY 2016
VL 32
IS 5
BP 449
EP 453
DI 10.1123/jab.2015-0038
PG 5
WC Engineering, Biomedical; Sport Sciences
SC Engineering; Sport Sciences
GA DY2VS
UT WOS:000384950800004
PM 27175485
ER
PT J
AU Coleman, BG
Johnson, TM
Erley, KJ
Topolski, R
Rethman, M
Lancaster, DD
AF Coleman, Brandon G.
Johnson, Thomas M.
Erley, Kenneth J.
Topolski, Richard
Rethman, Michael
Lancaster, Douglas D.
TI Preparing Dental Students and Residents to Overcome Internal and
External Barriers to Evidence-Based Practice
SO JOURNAL OF DENTAL EDUCATION
LA English
DT Editorial Material
DE dental education; evidence-based dentistry; evidence-based practice;
bias; cognition; human performance factors
ID RANDOMIZED CONTROLLED-TRIALS; EVIDENCE-BASED DENTISTRY;
CONFLICTS-OF-INTEREST; DECISION-MAKING; REPORTING QUALITY; LEADING
JOURNALS; MEDICAL JOURNALS; CLINICAL-TRIALS; BIAS; PUBLICATION
AB In recent years, evidence-based dentistry has become the ideal for research, academia, and clinical practice. However, barriers to implementation are many, including the complexity of interpreting conflicting evidence as well as difficulties in accessing it. Furthermore, many proponents of evidence-based care seem to assume that good evidence consistently exists and that clinicians can and will objectively evaluate data so as to apply the best evidence to individual patients' needs. The authors argue that these shortcomings may mislead many clinicians and that students should be adequately prepared to cope with some of the more complex issues surrounding evidence-based practice. Cognitive biases and heuristics shape every aspect of our lives, including our professional behavior. This article reviews literature from medicine, psychology, and behavioral economics to explore the barriers to implementing evidence-based dentistry. Internal factors include biases that affect clinical decision making hindsight bias, optimism bias, survivor bias, and blind-spot bias. External factors include publication bias, corporate bias, and lack of transparency that may skew the available evidence in the peer-reviewed literature. Raising awareness of how these biases exert subtle influence on decision making and patient care can lead to a more nuanced discussion of addressing and overcoming barriers to evidence-based practice.
C1 [Coleman, Brandon G.; Johnson, Thomas M.; Erley, Kenneth J.; Lancaster, Douglas D.] US Army Adv Educ Program Periodont, Ft Gordon, GA USA.
[Topolski, Richard] Augusta Univ, Dept Psychol Sci, Augusta, GA USA.
[Rethman, Michael] Univ Maryland, Baltimore Coll Dent Surg, Baltimore, MD 21201 USA.
[Rethman, Michael] Ohio State Univ, Coll Dent, Columbus, OH 43210 USA.
RP Coleman, BG (reprint author), US Army Adv Educ Program Periodont, Tingay Dent Clin, 320 E Hosp Rd, Ft Gordon, GA 30905 USA.
EM Brandon.G.Coleman2.mil@mail.mil
NR 60
TC 1
Z9 1
U1 5
U2 5
PU AMER DENTAL EDUCATION ASSOC-ADEA
PI WASHINGTON
PA 655 K STREET NW, SUITE 800, WASHINGTON, DC 20001 USA
SN 0022-0337
EI 1930-7837
J9 J DENT EDUC
JI J. Dent. Educ.
PD OCT
PY 2016
VL 80
IS 10
BP 1161
EP 1169
PG 9
WC Dentistry, Oral Surgery & Medicine
SC Dentistry, Oral Surgery & Medicine
GA DY4FS
UT WOS:000385055000002
PM 27694289
ER
PT J
AU Gordon, SN
Liyanage, NPM
Doster, MN
Vaccari, M
Vargas-Inchaustegui, DA
Pegu, P
Schifanella, L
Shen, XY
Tomaras, GD
Rao, M
Billings, EA
Schwartz, J
Prado, I
Bobb, K
Zhang, WL
Montefiori, DC
Foulds, KE
Ferrari, G
Robert-Guroff, M
Roederer, M
Phan, TB
Forthal, DN
Stablein, DM
Phogat, S
Venzon, DJ
Fouts, T
Franchini, G
AF Gordon, Shari N.
Liyanage, Namal P. M.
Doster, Melvin N.
Vaccari, Monica
Vargas-Inchaustegui, Diego A.
Pegu, Poonam
Schifanella, Luca
Shen, Xiaoying
Tomaras, Georgia D.
Rao, Mangala
Billings, Erik A.
Schwartz, Jennifer
Prado, Ilia
Bobb, Kathryn
Zhang, Wenlei
Montefiori, David C.
Foulds, Kathryn E.
Ferrari, Guido
Robert-Guroff, Marjorie
Roederer, Mario
Phan, Tran B.
Forthal, Donald N.
Stablein, Donald M.
Phogat, Sanjay
Venzon, David J.
Fouts, Timothy
Franchini, Genoveffa
TI Boosting of ALVAC-SIV Vaccine-Primed Macaques with the CD4-SIVgp120
Fusion Protein Elicits Antibodies to V2 Associated with a Decreased Risk
of SIVmac251 Acquisition
SO JOURNAL OF IMMUNOLOGY
LA English
DT Article
ID DEPENDENT CELLULAR CYTOTOXICITY; IMMUNODEFICIENCY VIRUS SIV; SIMIAN
IMMUNODEFICIENCY; RHESUS MACAQUES; HIV-1 VACCINE; MEDIATED CYTOTOXICITY;
SHIV CHALLENGE; GAG/POL/NEF VACCINE; ENVELOPE PROTEIN; EFFICACY TRIAL
AB The recombinant ALVAC vaccine coupled with the monomeric gp120/alum protein have decreased the risk of HIV and SIV acquisition. Ab responses to the V1/V2 regions have correlated with a decreased risk of virus acquisition in both humans and macaques. We hypothesized that the breadth and functional profile of Abs induced by an ALVAC/envelope protein regimen could be improved by substituting the monomeric gp120 boost, with the full-length single-chain (FLSC) protein. FLSC is a CD4-gp120 fusion immunogen that exposes cryptic gp120 epitopes to the immune system. We compared the immunogenicity and relative efficiency of an ALVAC-SIV vaccine boosted either with bivalent FLSC proteins or with monomeric gp120 in alum. FLSC was superior to monomeric gp120 in directing Abs to the C3 alpha 2 helix, the V5 loop, and the V3 region that contains the putative CCR5 binding site. In addition, FLSC boosting elicited significantly higher binding Abs to V2 and increased both the Ab-dependent cellular cytotoxicity activity and the breadth of neutralizing Abs. However, the FLSC vaccine regimen demonstrated only a trend in vaccine efficacy, whereas the monomeric gp120 regimen significantly decreased the risk of SIVmac251 acquisition. In both vaccine regimens, anti-V2 Abs correlated with a decreased risk of virus acquisition but differed with regard to systemic or mucosal origin. In the FLSC regimen, serum Abs to V2 correlated, whereas in the monomeric gp120 regimen, V2 Abs in rectal secretions, the site of viral challenge, were associated with efficacy.
C1 [Gordon, Shari N.; Liyanage, Namal P. M.; Doster, Melvin N.; Vaccari, Monica; Pegu, Poonam; Schifanella, Luca; Franchini, Genoveffa] NCI, Anim Models & Vaccine Sect, NIH, 41 Lib Dr,Bldg 41,Room D804, Bethesda, MD 20892 USA.
[Vargas-Inchaustegui, Diego A.; Robert-Guroff, Marjorie] NCI, Immune Biol Retroviral Infect Sect, Vaccine Branch, Bethesda, MD 20892 USA.
[Shen, Xiaoying; Tomaras, Georgia D.; Montefiori, David C.; Ferrari, Guido] Duke Univ, Med Ctr, Durham, NC 27710 USA.
[Rao, Mangala; Billings, Erik A.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA.
[Schwartz, Jennifer; Prado, Ilia; Bobb, Kathryn; Zhang, Wenlei; Fouts, Timothy] Profectus BioSci Inc, Baltimore, MD 21224 USA.
[Foulds, Kathryn E.; Roederer, Mario] NIAID, Vaccine Res Ctr, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA.
[Phan, Tran B.; Forthal, Donald N.] Univ Calif Irvine, Div Infect Dis, Dept Med, Sch Med, Irvine, CA 92868 USA.
[Stablein, Donald M.] Emmes Corp, Rockville, MD 20850 USA.
[Phogat, Sanjay] Sanofi Pasteur, Swiftwater, PA 18370 USA.
[Venzon, David J.] NCI, Biostat & Data Management Sect, NIH, Bethesda, MD 20892 USA.
RP Franchini, G (reprint author), NCI, Anim Models & Vaccine Sect, NIH, 41 Lib Dr,Bldg 41,Room D804, Bethesda, MD 20892 USA.
EM franchig@mail.nih.gov
FU Intramural NIH HHS [Z01 BC005688-17]
NR 53
TC 0
Z9 0
U1 2
U2 2
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD OCT 1
PY 2016
VL 197
IS 7
BP 2726
EP 2737
DI 10.4049/jimmunol.1600674
PG 12
WC Immunology
SC Immunology
GA DY3OX
UT WOS:000385004600022
PM 27591322
ER
PT J
AU Tatel, DF
Wade, BSC
Velez, CS
Drennon, AM
Bolzenius, J
Gutman, BA
Thompson, PM
Lewis, JD
Wilde, EA
Bigler, ED
Shenton, ME
Ritter, JL
York, GE
AF Tatel, David F.
Wade, Benjamin S. C.
Velez, Carmen S.
Drennon, Ann Marie
Bolzenius, Jacob
Gutman, Boris A.
Thompson, Paul M.
Lewis, Jeffrey D.
Wilde, Elisabeth A.
Bigler, Erin D.
Shenton, Martha E.
Ritter, John L.
York, Gerald E.
TI Volumetric and shape analyses of subcortical structures in United States
service members with mild traumatic brain injury
SO JOURNAL OF NEUROLOGY
LA English
DT Article
DE Mild traumatic brain injury; Military; mTBI; Subcortical structures;
Volumetric measures; Shape analyses; Service members
ID POSTTRAUMATIC-STRESS-DISORDER; TENSOR IMAGING FINDINGS; HIPPOCAMPAL
VOLUME; NUCLEUS-ACCUMBENS; CORTICAL THICKNESS; AMYGDALA; MORPHOMETRY;
INTEGRITY; VETERANS; ATROPHY
AB Mild traumatic brain injury (mTBI) is a significant health concern. The majority who sustain mTBI recover, although similar to 20 % continue to experience symptoms that can interfere with quality of life. Accordingly, there is a critical need to improve diagnosis, prognostic accuracy, and monitoring (recovery trajectory over time) of mTBI. Volumetric magnetic resonance imaging (MRI) has been successfully utilized to examine TBI. One promising improvement over standard volumetric approaches is to analyze high-dimensional shape characteristics of brain structures. In this study, subcortical shape and volume in 76 Service Members with mTBI was compared to 59 Service Members with orthopedic injury (OI) and 17 with post-traumatic stress disorder (PTSD) only. FreeSurfer was used to quantify structures from T1-weighted 3 T MRI data. Radial distance (RD) and Jacobian determinant (JD) were defined vertex-wise on parametric mesh-representations of subcortical structures. Linear regression was used to model associations between morphometry (volume and shape), TBI status, and time since injury (TSI) correcting for age, sex, intracranial volume, and level of education. Volumetric data was not significantly different between the groups. JD was significantly increased in the accumbens and caudate and significantly reduced in the thalamus of mTBI participants. Additional significant associations were noted between RD of the amygdala and TSI. Positive trend-level associations between TSI and the amygdala and accumbens were observed, while a negative association was observed for third ventricle. Our findings may aid in the initial diagnosis of mTBI, provide biological targets for functional examination, and elucidate regions that may continue remodeling after injury.
C1 [Tatel, David F.; Velez, Carmen S.; Bolzenius, Jacob] Univ Missouri, Missouri Inst Mental Hlth, 4633 World Pkwy Circle, Berkeley, MO 63134 USA.
[Tatel, David F.; Wilde, Elisabeth A.] Baylor Coll Med, Dept Phys Med & Rehabil, Houston, TX 77030 USA.
[Wade, Benjamin S. C.; Gutman, Boris A.; Thompson, Paul M.] Univ So Calif, Imaging Genet Ctr, Marina Del Rey, CA USA.
[Drennon, Ann Marie] San Antonio Mil Med Ctr, Def & Vet Brain Injury Ctr, San Antonio, TX USA.
[Lewis, Jeffrey D.] Uniformed Serv Univ Hlth Sci, Dept Neurol, Sch Med, Bethesda, MD 20814 USA.
[Wilde, Elisabeth A.] Michael E DeBakey VA Med Ctr, Houston, TX USA.
[Bigler, Erin D.] Brigham Young Univ, Dept Psychol, Provo, UT 84602 USA.
[Bigler, Erin D.] Brigham Young Univ, Dept Neurosci, Provo, UT 84602 USA.
[Shenton, Martha E.] Harvard Med Sch, Brigham & Womens Hosp, Dept Psychiat & Radiol, Psychiat Neuroimaging Lab, Boston, MA USA.
[Shenton, Martha E.] VA Boston Healthcare Syst, Brockton Div, Brockton, MA USA.
[Ritter, John L.] Brooke Army Med Ctr, Dept Radiol, San Antonio, TX USA.
[York, Gerald E.] Alaska Radiol Associates, TBI Imaging & Res, Anchorage, AK USA.
RP Tatel, DF (reprint author), Univ Missouri, Missouri Inst Mental Hlth, 4633 World Pkwy Circle, Berkeley, MO 63134 USA.; Tatel, DF (reprint author), Baylor Coll Med, Dept Phys Med & Rehabil, Houston, TX 77030 USA.
EM David.Tate@mimh.edu
RI Tate, David/I-3963-2013;
OI Tate, David/0000-0003-0213-1920
FU Defense and Veterans Brain Injury Centers; Telemedicine and Advanced
Technology Research Center (TATRC) at the U.S. Army Medical Research and
Materiel Command (USAMRMC) [W81XWH-13-2-0025]; Chronic Effects of
Neurotrauma Consortium (CENC) [PT108802-SC104835]; National Institutes
of Health (NIH) [U54 EB020403]; Veterans Administration (VA Merit Grant)
FX The view(s) expressed herein are those of the author and do not reflect
the official policy or position of the Defense and Veterans Brain Injury
Center, Brooke Army Medical Center, the U.S. Army Medical Department,
the U.S. Army Office of the Surgeon General, the Department of the Army,
Department of Defense, or the U.S. Government. We gratefully acknowledge
the generous time and effort that the Service Members made in supporting
this study. We also gratefully acknowledge the clinical effort and
expertise of the Brooke Army Medical Center Brain Injury and
Rehabilitation Service staff in the identification, recruitment,
consenting, and treatment of Service Members who are a part of this
study. This work is supported in part by the Defense and Veterans Brain
Injury Centers, the Telemedicine and Advanced Technology Research Center
(TATRC) at the U.S. Army Medical Research and Materiel Command (USAMRMC;
W81XWH-13-2-0025), the Chronic Effects of Neurotrauma Consortium (CENC;
PT108802-SC104835), the National Institutes of Health (NIH U54
EB020403), and the Veterans Administration (VA Merit Grant).
NR 74
TC 0
Z9 0
U1 5
U2 5
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0340-5354
EI 1432-1459
J9 J NEUROL
JI J. Neurol.
PD OCT
PY 2016
VL 263
IS 10
BP 2065
EP 2079
DI 10.1007/s00415-016-8236-7
PG 15
WC Clinical Neurology
SC Neurosciences & Neurology
GA DY5WA
UT WOS:000385173900019
PM 27435967
ER
PT J
AU Mason, GL
Vahedifard, F
Robinson, JD
Howard, IL
McKinley, GB
Priddy, JD
AF Mason, George L.
Vahedifard, Farshid
Robinson, Joe D.
Howard, Isaac L.
McKinley, George B.
Priddy, Jody D.
TI Improved sinkage algorithms for powered and unpowered wheeled vehicles
operating on sand
SO JOURNAL OF TERRAMECHANICS
LA English
DT Article
DE Vehicle off-road mobility; Sand; Traction; Sinkage; Vehicle Terrain
Interface (VTI); Database Records for Off-road Vehicle Environments
(DROVE)
ID PRESSURE; MOBILITY; TERRAIN
AB Modeling and simulation of vehicles in sand is critical for characterizing off-road mobility in arid and coastal regions. This paper presents improved algorithms for calculating sinkage (z) of wheeled vehicles operating on loose dry sand. The algorithms are developed based on 2737 tests conducted on sand with 23 different wheel configurations. The test results were collected from Database Records for Off-road Vehicle Environments (DROVE), a recently developed database of tests conducted with wheeled vehicles operating in loose dry sand. The study considers tire diameters from 36 to 124 cm with wheel loads of 0.19-36.12 kN. The proposed algorithms present a simple form of sinkage relationships, which only require the ratio of the wheel ground contact pressure and soil strength represented by cone index. The proposed models are compared against existing closed form solutions defined in the Vehicle Terrain Interface (VTI) model. Comparisons suggest that incorporating the proposed models into the VTI model can provide comparable predictive accuracy with simpler algorithms. In addition to simplicity, it is believed that the relationship between cone index (representing soil shear strength) and the contact pressure (representing the applied pressure to tire-soil interface) can better capture the physics of the problem being evaluated. (C) 2016 ISTVS. Published by Elsevier Ltd. All rights reserved.
C1 [Mason, George L.; Vahedifard, Farshid; Robinson, Joe D.; Howard, Isaac L.] Mississippi State Univ, CAVS, Mississippi State, MS 39762 USA.
[Vahedifard, Farshid; Robinson, Joe D.; Howard, Isaac L.] Mississippi State Univ, Dept Civil & Environm Engn, Mississippi State, MS 39762 USA.
[Robinson, Joe D.] Terracon Consultants Inc, Chattanooga, TN 37406 USA.
[McKinley, George B.; Priddy, Jody D.] US Army, ERDC, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
RP Vahedifard, F (reprint author), Mississippi State Univ, Dept Civil & Environm Engn, Mississippi State, MS 39762 USA.
EM George.L.Mason.PE@engineer.com; farshid@cee.msstate.edu;
Jody.Robinson@terracon.com; ilhoward@cee.msstate.edu;
George.B.Mckinley@usace.army.mil; Jody.D.Priddy@usace.army.mil
FU U.S. Government [W15QKN-13-9-0001]
FX This effort was sponsored by the U.S. Government under Other Transaction
number W15QKN-13-9-0001 between the Consortium for Energy, Environment
and Demilitarization, and the Government. The U.S. Government is
authorized to reproduce and distribute reprints for Governmental
purposes notwithstanding any copyright notation thereon. The views and
conclusions contained herein are those of the authors and should not be
interpreted as necessarily representing the official policies or
endorsements, either expressed or implied, of the U.S. Government. The
authors would like to thank Levi Weeks and Clinton Carlisle for their
assistance in extracting data from various reports and assembling the
database. This paper is based on the work conducted under Task 12:
Mobility Modeling for Soils. Roger King, Director of the Center for
Advanced Vehicular Systems (CAVS) at Mississippi State University, was
principal investigator for W15QKN-13-9-0001 and Farshid Vahedifard was
the lead for Task 12.
NR 28
TC 0
Z9 0
U1 0
U2 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-4898
EI 1879-1204
J9 J TERRAMECHANICS
JI J. Terramech.
PD OCT
PY 2016
VL 67
BP 25
EP 36
DI 10.1016/j.jterra.2016.07.001
PG 12
WC Engineering, Environmental
SC Engineering
GA DY1KE
UT WOS:000384853100003
ER
PT J
AU Miller, RS
Foster, JW
AF Miller, Richard S.
Foster, Justin W.
TI Survey of Turbulent Combustion Models for Large-Eddy Simulations of
Propulsive Flowfields
SO AIAA JOURNAL
LA English
DT Article; Proceedings Paper
CT 53rd AIAA Aerospace Sciences Meeting / AIAA Atmospheric Flight Mechanics
Conference / 17th AIAA Non-Deterministic Approaches Conference / AIAA
Science and Technology Forum and Exposition (SciTech) / AIAA Infotech at
Aerospace Conference
CY JAN 05-09, 2015
CL Kissimmee, FL
SP AIAA
ID FILTERED DENSITY-FUNCTION; FLAMELET-GENERATED MANIFOLDS; PARTIALLY
PREMIXED FLAMES; COMBINED DIMENSION REDUCTION; DIRECT NUMERICAL
SIMULATIONS; SUBGRID-SCALE MODELS; METHANE JET FLAMES; REACTING FLOWS;
HIGH-PRESSURE; MIXTURE FRACTION
C1 [Miller, Richard S.] Clemson Univ, Dept Mech Engn, Clemson, SC 29634 USA.
[Foster, Justin W.] Corvid Technol, Mooresville, NC 28117 USA.
[Foster, Justin W.] US Army Engineer Res & Dev Ctr, Res Mech Engineer Dept, Vicksburg, MS 39180 USA.
RP Miller, RS (reprint author), Clemson Univ, Dept Mech Engn, Clemson, SC 29634 USA.
EM rm@clemson.edu
NR 219
TC 0
Z9 0
U1 3
U2 3
PU AMER INST AERONAUTICS ASTRONAUTICS
PI RESTON
PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091-4344 USA
SN 0001-1452
EI 1533-385X
J9 AIAA J
JI AIAA J.
PD OCT
PY 2016
VL 54
IS 10
BP 2930
EP 2946
DI 10.2514/1.J054740
PG 17
WC Engineering, Aerospace
SC Engineering
GA DX5TH
UT WOS:000384444400002
ER
PT J
AU Balsara, HD
Banton, RJ
Eggleton, CD
AF Balsara, Hiren D.
Banton, Rohan J.
Eggleton, Charles D.
TI Investigating the effects of membrane deformability on artificial
capsule adhesion to the functionalized surface
SO BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
LA English
DT Article
DE Adhesion mechanics; Capsule deformation; Immersed boundary method; Monte
Carlo simulation; Leuko-polymersomes
ID THIN-FILM DRAINAGE; SELECTIN GLYCOPROTEIN LIGAND-1; ROLLING IN-VIVO;
SHEAR-FLOW; LEUKOCYTE ADHESION; SOLID WALL; FLUID DROP; CELL;
DEFORMATION; POLYMERSOMES
AB Understanding, manipulating and controlling cellular adhesion processes can be critical in developing biomedical technologies. Adhesive mechanisms can be used to the target, pattern and separate cells such as leukocytes from whole blood for biomedical applications. The deformability response of the cell directly affects the rolling and adhesion behavior under viscous linear shear flow conditions. To that end, the primary objective of the present study was to investigate numerically the influence of capsule membrane's nonlinear material behavior (i.e. elastic-plastic to strain hardening) on the rolling and adhesion behavior of representative artificial capsules. Specifically, spherical capsules with radius of were represented using an elastic membrane governed by a Mooney-Rivlin strain energy functions. The surfaces of the capsules were coated with P-selectin glycoprotein-ligand-1 to initiate binding interaction with P-selectin-coated planar surface with density of under linear shear flow varying from 100 to . The numerical model is based on the Immersed Boundary Method for rolling of deformable capsule in shear flow coupled with Monte Carlo simulation for receptor/ligand interaction modeled using Bell model. The results reveal that the mechanical properties of the capsule play an important role in the rolling behavior and the binding kinetics between the capsule contact surface and the substrate. The rolling behavior of the strain hardening capsules is relatively smoother and slower compared to the elastic-plastic capsules. The strain hardening capsules exhibits higher contact area at any given shear rate compared to elastic-plastic capsules. The increase in contact area leads to decrease in rolling velocity. The capsule contact surface is not in complete contact with the substrate because of thin lubrication film that is trapped between the capsule and substrate. This creates a concave shape on the bottom surface of the capsule that is referred to as a dimple. In addition, the present study demonstrates that the average total bond force from the capsules lifetime increases by 37 % for the strain hardening capsules compared to elastic-plastic capsules at shear rate of . Finally, the model demonstrates the effect of finite membrane deformation on the coupling between hydrodynamic and receptor/ligand interaction.
C1 [Balsara, Hiren D.; Eggleton, Charles D.] Univ Maryland Baltimore Cty, Dept Mech Engn, Baltimore, MD 21250 USA.
[Banton, Rohan J.] US Army Res Lab, Aberdeen, MD USA.
RP Eggleton, CD (reprint author), Univ Maryland Baltimore Cty, Dept Mech Engn, Baltimore, MD 21250 USA.
EM eggleton@umbc.edu
FU US National Science Foundation through the MRI program [CNS-0821258,
CNS-1228778]; SCREMS program [DMS-0821311]; University of Maryland,
Baltimore County (UMBC)
FX The hardware used in the computational studies is part of the UMBC High
Performance Computing Facility (HPCF). The facility is supported by the
US National Science Foundation through the MRI program (Grant Nos.
CNS-0821258 and CNS-1228778) and the SCREMS program (Grant No.
DMS-0821311), with additional substantial support from the University of
Maryland, Baltimore County (UMBC). See www.umbc.edu/hpcf for more
information on HPCF and the projects using its resources.
NR 57
TC 0
Z9 0
U1 2
U2 2
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1617-7959
EI 1617-7940
J9 BIOMECH MODEL MECHAN
JI Biomech. Model. Mechanobiol.
PD OCT
PY 2016
VL 15
IS 5
BP 1055
EP 1068
DI 10.1007/s10237-015-0742-5
PG 14
WC Biophysics; Engineering, Biomedical
SC Biophysics; Engineering
GA DW4KM
UT WOS:000383611800004
PM 26564174
ER
PT J
AU Johnston, TK
Perkins, E
Ferguson, DC
Cropek, DM
AF Johnston, Theresa K.
Perkins, Edward
Ferguson, Duncan C.
Cropek, Donald M.
TI Tissue explant coculture model of the
hypothalamic-pituitary-gonadal-liver axis of the fathead minnow
(Pimephales promelas) as a predictive tool for endocrine disruption
SO ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
LA English
DT Article
DE Endocrine disruption; Fathead minnow; Hypothalamic-pituitary-gonadal
axis; Tissue coculture; Trenbolone
ID ANDROGEN-RECEPTOR; REPRODUCTIVE ENDOCRINOLOGY; SEXUAL-DIFFERENTIATION;
JAPANESE MEDAKA; RISK-ASSESSMENT; MALE-RAT; 17-BETA-TRENBOLONE;
EXPOSURE; VITELLOGENIN; PROCYMIDONE
AB Endocrine-disrupting compounds (EDCs) can impact the reproductive system by interfering with the hypothalamic-pituitary-gonadal (HPG) axis. Although in vitro testing methods have been developed to screen chemicals for endocrine disruption, extrapolation of in vitro responses to in vivo action shows inconsistent accuracy. The authors describe a tissue coculture of the fathead minnow (Pimephales promelas) HPG axis and liver (HPG-L) as a tissue explant model that mimics in vivo results. Brain (hypothalamus), pituitary, gonad, and liver tissue explants from adult fish were examined for function both individually and in coculture to determine combinations and conditions that could replicate in vivo behavior. Only cocultures had the ability to respond to an EDC, trenbolone, similarly to in vivo studies, based on estradiol, testosterone, and vitellogenin production trends, where lower exposure doses suppressed hormone production but higher doses increased production, resulting in distinctive U-shaped curves. These data suggest that a coculture system with all components of the HPG-L axis can be used as a link between in vitro and in vivo studies to predict endocrine system disruption in whole organisms. This tissue-based HPG-L system acts as a flexible deconstructed version of the in vivo system for better control and examination of the minute changes in system operation and response on EDC exposure with options to isolate, interrogate, and recombine desired components. Environ Toxicol Chem 2016;35:2530-2541. Published 2016 Wiley Periodicals Inc. on behalf of SETAC. This article is a US Government work and, as such, is in the public domain in the United States of America.
C1 [Johnston, Theresa K.; Cropek, Donald M.] US Army Corps Engineers, Engineer Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61822 USA.
[Johnston, Theresa K.; Ferguson, Duncan C.; Cropek, Donald M.] Univ Illinois, Dept Comparat Biosci, Urbana, IL 61801 USA.
[Perkins, Edward] US Army Corps Engineers, Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS USA.
RP Cropek, DM (reprint author), US Army Corps Engineers, Engineer Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61822 USA.; Cropek, DM (reprint author), Univ Illinois, Dept Comparat Biosci, Urbana, IL 61801 USA.
EM Donald.m.cropek@usace.army.mil
FU US Army Corps of Engineers, Basic Research Program
FX We thank J. Flaws, M. Mahoney, and K. Keller for help with the present
study. The present study was supported by funding from the US Army Corps
of Engineers, Basic Research Program. Research was performed using
Protocol 12175 at the University of Illinois, Urbana-Champaign. The
authors had no conflict of interest.
NR 40
TC 0
Z9 0
U1 6
U2 6
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0730-7268
EI 1552-8618
J9 ENVIRON TOXICOL CHEM
JI Environ. Toxicol. Chem.
PD OCT
PY 2016
VL 35
IS 10
BP 2530
EP 2541
DI 10.1002/etc.3415
PG 12
WC Environmental Sciences; Toxicology
SC Environmental Sciences & Ecology; Toxicology
GA DY0UD
UT WOS:000384810800020
PM 26931821
ER
PT J
AU Tischler, MA
AF Tischler, Michael A.
TI Accelerating Geospatial Modeling in ArcGIS with Graphical Processor
Units
SO INTERNATIONAL JOURNAL OF APPLIED GEOSPATIAL RESEARCH
LA English
DT Article
DE ArcGIS; Geospatial; GIS; GPU; Python; Spatial Similarity
ID DENSITY-ESTIMATION
AB Geospatial data can be enormous in size and tedious to process efficiently on standard computational workstations. Distributing the processing tasks through highly parallelized processing reduces the burden on the primary processor and processing times can drastically shorten as a result. ERSI's ArcGIS, while widely used in the military, does not natively support multi-core processing or utilization of graphic processor units (GPUs). However, the ArcPy Python library included in ArcGIS 10 provides geospatial developers with the means to process geospatial data in a flexible environment that can be linked with GPU application programming interfaces (APIs). This research extends a custom desktop geospatial model of spatial similarity for remote soil classification which takes advantage of both standard ArcPy/ArcGIS geoprocessing functions and custom GPU kernels, operating on an NVIDIA Tesla S2050 equipped with potential access to 1792 cores. The author will present their results which describe hardware and software configurations, processing efficiency gains, and lessons learned.
C1 [Tischler, Michael A.] US Army Corps Engineers, Engn Res & Dev Ctr, Topog Engn Ctr, Washington, DC 20314 USA.
RP Tischler, MA (reprint author), US Army Corps Engineers, Engn Res & Dev Ctr, Topog Engn Ctr, Washington, DC 20314 USA.
NR 27
TC 0
Z9 0
U1 5
U2 5
PU IGI PUBL
PI HERSHEY
PA 701 E CHOCOLATE AVE, STE 200, HERSHEY, PA 17033-1240 USA
SN 1947-9654
EI 1947-9662
J9 INT J APPL GEOSPAT R
JI Int. J. Appl. Geospat. Res.
PD OCT-DEC
PY 2016
VL 7
IS 4
BP 41
EP 52
DI 10.4018/IJAGR.2016100104
PG 12
WC Geography
SC Geography
GA DX6WB
UT WOS:000384524700005
ER
PT J
AU Tennent, DJ
Shiels, SM
Sanchez, CJ
Niece, KL
Akers, KS
Stinner, DJ
Wenke, JC
AF Tennent, David J.
Shiels, Stefanie M.
Sanchez, Carlos J., Jr.
Niece, Krista L.
Akers, Kevin S.
Stinner, Daniel J.
Wenke, Joseph C.
TI Time-Dependent Effectiveness of Locally Applied Vancomycin Powder in a
Contaminated Traumatic Orthopaedic Wound Model
SO JOURNAL OF ORTHOPAEDIC TRAUMA
LA English
DT Article
DE infection; vancomycin; open fracture
ID SURGICAL SITE INFECTIONS; SEVERE OPEN FRACTURES; IN-VITRO; INTRAVENOUS
ANTIBIOTICS; POLYURETHANE SCAFFOLDS; BIOFILM FORMATION; REDUCE
INFECTION; SEGMENTAL DEFECT; SPINE SURGERY; RAT FEMUR
AB Objectives:To evaluate the effectiveness of locally applied vancomycin powder at different times postinfection in a contaminated traumatic animal model.Methods:This study used an established segmental defect rat femur model contaminated with Staphylococcus aureus UAMS-1 followed by treatment at 6 or 24 hours postinfection. Three treatments were evaluated: debridement and irrigation alone (control group) or in combination with either vancomycin powder or vancomycin-impregnated poly(methyl methacrylate) beads. Serum vancomycin levels were determined at scheduled time points over 14 days; bone, surrounding muscle, and implants were harvested for bacterial and inflammatory analyses.Results:Locally applied vancomycin powder and impregnated beads significantly reduced bacteria both within the bone and implant when treatment was performed at 6 hours. Delaying treatment to 24 hours significantly reduced the therapeutic efficacy of locally applied vancomycin of both groups. Serum vancomycin levels were detectable in all animals treated with vancomycin powder at 24 hours, but absorption was negligible from beads. At 14 days, vancomycin was detectable in the surrounding musculature of all animals and in serum of 20% of animals treated with vancomycin powder.Conclusions:This study suggests that vancomycin powder is a promising adjunctive therapy for preventing infection in traumatic wounds when treatment is performed early. This time-dependent effectiveness of vancomycin powder is similar to that observed with systemic and other local delivery adjuncts, which is likely attributable to biofilm formation after contamination, conferring intrinsic recalcitrance to antimicrobials.
C1 [Tennent, David J.; Shiels, Stefanie M.; Sanchez, Carlos J., Jr.; Niece, Krista L.; Akers, Kevin S.; Stinner, Daniel J.; Wenke, Joseph C.] US Army, Inst Surg Res, San Antonio, TX USA.
[Tennent, David J.; Stinner, Daniel J.] San Antonio Mil Med Ctr, Dept Orthopaed, Ft Sam Houston, TX USA.
RP Tennent, DJ (reprint author), San Antonio Mil Med Ctr, Ft Sam Houston, TX 78234 USA.
EM david.j.tennent.mil@mail.mil
OI Shiels, Stefanie/0000-0002-5904-3107
FU Orthopaedic Trauma Association
FX Supported by a grant from the Orthopaedic Trauma Association.
NR 44
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0890-5339
EI 1531-2291
J9 J ORTHOP TRAUMA
JI J. Orthop. Trauma
PD OCT
PY 2016
VL 30
IS 10
BP 531
EP 537
DI 10.1097/BOT.0000000000000617
PG 7
WC Orthopedics; Sport Sciences
SC Orthopedics; Sport Sciences
GA DX6BK
UT WOS:000384467000011
PM 27124826
ER
PT J
AU Chen, SE
Leeman, ME
English, BJ
Kennedy, AB
Masters, FJ
Pinelli, JP
Pang, WC
Rullan-Rodriguez, JA
Satyanarayana, P
Calvo, J
Murugan, B
Natarajan, C
AF Chen, Shen En
Leeman, Mark E.
English, Brandon J.
Kennedy, Andrew B.
Masters, Forrest J.
Pinelli, Jean Paul
Pang, Weichiang
Rullan-Rodriguez, Jose A.
Satyanarayana, P.
Calvo, Joseph
Murugan, Bharathi
Natarajan, C.
TI Basic Structure System Rating of Post-Super Typhoon Haiyan Structures in
Tacloban and East Guiuan, Philippines
SO JOURNAL OF PERFORMANCE OF CONSTRUCTED FACILITIES
LA English
DT Article
DE Super Typhoon Haiyan; Tacloban; Phillipines; Wind and water damage;
Storm surge; Basic rating
ID TROPICAL CYCLONES; SEA
AB This paper reports the investigation outcomes of the recent Super Typhoon Haiyan (also known as Hurricane Yolanda) in the Philippines using a basic structure damage rating technique. The rating technique ranked damaged conditions based on a 0 to 3 rating. A total of 156 structures were analyzed using the rating technique. Unlike previously published condition ratings, the technique does not include functional assessments such as mechanical and electrical systems and does not directly consider habitant safety nor costs to structure. The intent of the rating is to provide a quantitative measure of the effects of Haiyan. The outcomes indicate that wind damage dominated as the major cause of failures (53%) and that roof damage is the most significant of the damage modes (21%). The rating gives a first-order assessment of the damaged conditions of the structures pertaining to the loading effects (wind, water or storm surge, or combined) from Super Typhoon Haiyan. (C) 2016 American Society of Civil Engineers.
C1 [Chen, Shen En; Calvo, Joseph] Univ North Carolina Charlotte, Dept Civil & Environm Engn, Charlotte, NC 28223 USA.
[Leeman, Mark E.] Mosa Engn & Consulting, 3033 Wilson Blvd,Suite 700, Arlington, VA 22201 USA.
[English, Brandon J.] Conestoga Rovers & Associates, 1502 SW 41st St, Overland Pk, KS 66609 USA.
[Kennedy, Andrew B.] Univ Notre Dame, Dept Civil & Environm Engn & Earth Sci, Notre Dame, IN 46556 USA.
[Masters, Forrest J.] Univ Florida, Dept Civil & Coastal Engn, Gainesville, FL 32611 USA.
[Pinelli, Jean Paul] Florida Inst Technol, Dept Civil Engn, Melbourne, FL 32901 USA.
[Pang, Weichiang] Clemson Univ, Glenn Dept Civil Engn, Clemson, SC 29634 USA.
[Rullan-Rodriguez, Jose A.] US Army Corps Engineers, Engn Res & Dev Ctr, Geotech Struct Lab, Struct Mech Branch, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
[Satyanarayana, P.; Murugan, Bharathi; Natarajan, C.] Natl Inst Technol Trichy, Dept Civil Engn, Tiruchchirappalli, Tamil Nadu, India.
RP Chen, SE (reprint author), Univ North Carolina Charlotte, Dept Civil & Environm Engn, Charlotte, NC 28223 USA.
EM schen12@uncc.edu; mark.leeman@mosaiceng.com; jenglish@craworld.com;
Andrew.b.kennedy.117@nd.edu; masters@ce.ufl.edu; pinelli@fit.edu;
wpang@clemson.edu; jose.a.rullan-rodriguez@usace.army.mil;
satyanarayana.pothulas@gmail.com; jcalvo2@uncc.edu;
rbmmecivil@gmail.com; nataraj@nitt.edu
RI Masters, Forrest/D-1287-2011; Kennedy, Andrew/E-4746-2011
OI Masters, Forrest/0000-0001-8203-9846; Kennedy,
Andrew/0000-0002-7254-1346
FU National Science Foundation (NSF) Program [1426445, 1433262]; PICE; ASCE
Region [10]
FX The field team would like to extend its gratitude and appreciation to
ASCE for sponsoring the study and to committee on technical advancements
(CTA) for approving the project, in particular CTA members Mr. Bob
Bachman and Ron Smith for their guidance. Also, the field team would
also like to extend special acknowledgement to ASCE staff members Mr.
Jim Rossburg, Mr. John Segna, Ms. Meggan Maughan-Brown, and Mr. Tenzing
Barshee for their tireless support and facilitation of the project. The
field team also greatly appreciated the efforts of Mr. Doug Scott for
daily blog updates of the field team study. The authors would like to
acknowledge National Science Foundation (NSF) Program Director Dr.
Kishor Mehta for supporting this project under awards 1426445 and
1433262. The authors are grateful to the local support from PICE and
ASCE Region 10. The field team is thankful for meeting Under Secretary
Honorable Danilo Antonio and for receiving support from PICE President
Ernesto S. De Castro and former ASCE Region 10 Director, Potenciano A.
Leoncio, Jr. Gratitude is especially due to the logistic arrangements
made by PICE national administrative officer Nannette C. Villanueva and
Mr. Ferdie Briones. This project is a team effort from ASCE members,
ASCE international partners, and people from the area of Leyte. Without
ASCE's international partners, it would have been impossible to conduct
such studies. Meeting with several local mayors, including Mayor of
Tanauan Mr. Pelagio O. Tecson III, Mayor of Palo Ms. Remedios L.
Petilla, Mayor of Dulag Mr. Manuel S. Que, Mayor of Tolosa Erwin C.
Ocana, Region VIII Department of Public Works and Highways Director Mr.
Rolando M. Asis, and Port Manager of Port Management Office of Tacloban
City Mr. Dominador D. Licayan, allowed the field team to hear firsthand
the unfortunate events and the suffering of their constituents. These
mayors are courageous and dedicated in bringing in external resources to
help bring lives back to normal. The authors also like to acknowledge
the University of North Carolina Charlotte Mosaic team for putting
together the website in record time including Jack Stein, David
Whistler, Jason Edgecombe, Sai Phaninder Jonnala, Bryron Ho, Andre
Sanchez, Vivek Pawar, and Nathaniel Hatley. Shen-En Chen would like to
acknowledge the Fulbright-Nehru Scholarship that allowed him time to
analyze the data in Tirchuchirappalli, India. Last but not least, the
authors acknowledge local team members, especially the two translators
Valerie Ambait and Nile April Robino. Both are law school students who
spent days with the team amidst their busy exam schedules.
NR 17
TC 0
Z9 0
U1 9
U2 9
PU ASCE-AMER SOC CIVIL ENGINEERS
PI RESTON
PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA
SN 0887-3828
EI 1943-5509
J9 J PERFORM CONSTR FAC
JI J. Perform. Constr. Facil.
PD OCT
PY 2016
VL 30
IS 5
AR 04016033
DI 10.1061/(ASCE)CF.1943-5509.0000872
PG 11
WC Construction & Building Technology; Engineering, Civil
SC Construction & Building Technology; Engineering
GA DX3CF
UT WOS:000384249700025
ER
PT J
AU Grussing, MN
Liu, LY
Uzarski, DR
El-Rayes, K
El-Gohary, N
AF Grussing, Michael N.
Liu, Liang Y.
Uzarski, Donald R.
El-Rayes, Khaled
El-Gohary, Nora
TI Discrete Markov Approach for Building Component Condition, Reliability,
and Service-Life Prediction Modeling
SO JOURNAL OF PERFORMANCE OF CONSTRUCTED FACILITIES
LA English
DT Article
DE Asset management; Condition index; Deterioration modeling; Markov
process
ID DETERIORATION; SYSTEMS; CHAIN
AB Condition indexes have been developed to measure building component condition degradation due to age, use, and deterioration in support of asset management tasks related to work identification, planning, and prioritization. With the development of these indexes, a vast amount of condition index data have been collected for a wide range of components in buildings of varying type, use, and geographic location. The U.S. Department of Defense has implemented a standardized condition-assessment approach applied to thousands of Department-owned buildings, resulting in a vast condition index dataset to support more in-depth study of building component condition and reliability. This paper explores the existing data and develops a rigorous definition of the relationship between component condition, failure, and reliability. Presented is an approach using Markov transition probabilities to analyze the existing component condition datasets. This approach provides an improved method for predicting future condition index values based on past inspection results that are not based solely on inputs traditionally prone to error, such as component age and expected service life. It also results in a reliability metric that relates to a component's probability of failure, providing a much needed measure to manage risk. (C) 2016 American Society of Civil Engineers.
C1 [Grussing, Michael N.] US Army Corps Engineers, Engineer Res & Dev Ctr, Champaign, IL 61822 USA.
[Liu, Liang Y.; Uzarski, Donald R.; El-Rayes, Khaled; El-Gohary, Nora] Univ Illinois, Dept Civil & Environm Engn, Champaign, IL 61801 USA.
RP Grussing, MN (reprint author), US Army Corps Engineers, Engineer Res & Dev Ctr, Champaign, IL 61822 USA.
EM michael.n.grussing@usace.army.mil
NR 23
TC 0
Z9 0
U1 3
U2 3
PU ASCE-AMER SOC CIVIL ENGINEERS
PI RESTON
PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA
SN 0887-3828
EI 1943-5509
J9 J PERFORM CONSTR FAC
JI J. Perform. Constr. Facil.
PD OCT
PY 2016
VL 30
IS 5
AR 04016015
DI 10.1061/(ASCE)CF.1943-5509.0000865
PG 9
WC Construction & Building Technology; Engineering, Civil
SC Construction & Building Technology; Engineering
GA DX3CF
UT WOS:000384249700018
ER
PT J
AU Cannon, JW
Hofmann, LJ
Glasgow, SC
Potter, BK
Rodriguez, CJ
Cancio, LC
Rasmussen, TE
Fries, CA
Davis, MR
Jezior, JR
Mullins, RJ
Elster, EA
AF Cannon, Jeremy W.
Hofmann, Luke J.
Glasgow, Sean C.
Potter, Benjamin K.
Rodriguez, Carlos J.
Cancio, Leopoldo C.
Rasmussen, Todd E.
Fries, C. Anton
Davis, Michael R.
Jezior, James R.
Mullins, Richard J.
Elster, Eric A.
TI Dismounted Complex Blast Injuries: A Comprehensive Review of the Modern
Combat Experience
SO JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
LA English
DT Review
ID IMPROVISED EXPLOSIVE DEVICES; INVASIVE FUNGAL-INFECTIONS;
DAMAGE-CONTROL; EXTREMITY INJURIES; CASUALTY CARE; TRAUMA; MANAGEMENT;
MILITARY; MORTALITY; RELEVANCE
AB One of the most challenging injury patterns to emerge from the recent military conflicts in Iraq and Afghanistan is the dismounted complex blast injury (DCBI), with multiple proximal amputations, pelvic fractures, and extensive perineal wounds (Fig. 1).(1-5) Lessons learned from managing patients with this pattern of injury must be captured to minimize the morbidity and mortality of those suffering similar injuries in the future. These lessons also apply to civilian patients suffering open pelvic fractures and crush injuries to the pelvis. 6 The aim of this review was to detail the diagnostic work-up and initial multidisciplinary management of DCBI patients, to describe some of the most common complications after DCBI, and to discuss future research efforts to improve the survivability and outcomes of DCBI.
C1 [Cannon, Jeremy W.] Univ Penn, Dept Surg, Perelman Sch Med, Philadelphia, PA 19104 USA.
[Hofmann, Luke J.] William Beaumont Army Med Ctr, El Paso, TX 79920 USA.
[Mullins, Richard J.] Oregon Hlth & Sci Univ, Portland, OR 97201 USA.
[Hofmann, Luke J.; Rodriguez, Carlos J.; Davis, Michael R.; Elster, Eric A.] Uniformed Serv Univ Hlth Sci, Walter Reed Dept Surg, Dept Gen Surg, Bethesda, MD USA.
[Potter, Benjamin K.] Uniformed Serv Univ Hlth Sci, Walter Reed Dept Surg, Dept Orthopaed, Bethesda, MD USA.
[Rasmussen, Todd E.] Uniformed Serv Univ Hlth Sci, Walter Reed Dept Surg, Dept Vasc Surg, Bethesda, MD USA.
[Jezior, James R.] Uniformed Serv Univ Hlth Sci, Walter Reed Dept Surg, Dept Urol, Bethesda, MD USA.
[Glasgow, Sean C.] Washington Univ, Dept Surg, St Louis, MO USA.
[Glasgow, Sean C.] USAF Ctr Sustainment Trauma & Resuscitat Skills C, St Louis, MO USA.
[Cancio, Leopoldo C.; Fries, C. Anton; Davis, Michael R.] US Army Inst Surg Res, Ft Sam Houston, TX USA.
[Rasmussen, Todd E.] US Combat Casualty Care Res Program, Ft Detrick, MD USA.
RP Cannon, JW (reprint author), Penn Presbyterian Med Ctr, Div Trauma Surg Crit Care & Emergency Surg, 51 N 39th St,Med Off Bldg,Suite 120, Philadelphia, PA 19104 USA.
EM jeremy.cannon@uphs.upenn.edu
OI Potter, MD, Benjamin K./0000-0002-8771-0317
NR 40
TC 0
Z9 0
U1 8
U2 8
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1072-7515
EI 1879-1190
J9 J AM COLL SURGEONS
JI J. Am. Coll. Surg.
PD OCT
PY 2016
VL 223
IS 4
BP 652
EP +
DI 10.1016/j.jamcollsurg.2016.07.009
PG 21
WC Surgery
SC Surgery
GA DX9FC
UT WOS:000384698000015
PM 27481095
ER
PT J
AU Dorothy, M
Chung, SJ
AF Dorothy, Michael
Chung, Soon-Jo
TI Switched systems with multiple invariant sets
SO SYSTEMS & CONTROL LETTERS
LA English
DT Article
DE Switched systems; Non-equilibrium steady state; Set-based control
AB This paper explores dwell time constraints on switched systems with multiple, possibly disparate invariant limit sets. We show that, under suitable conditions, trajectories globally converge to a superset of the limit sets and then remain in a second, larger superset. We show the effectiveness of the dwell time conditions by using examples of switching limit cycles commonly found in robotic locomotion and flapping flight. (C) 2016 Elsevier B.V. All rights reserved.
C1 [Dorothy, Michael; Chung, Soon-Jo] Univ Illinois, Dept Aerosp Engn, Urbana, IL 61801 USA.
[Dorothy, Michael] Army Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RP Chung, SJ (reprint author), Univ Illinois, Dept Aerosp Engn, Urbana, IL 61801 USA.
EM michael.r.dorothy.civ@mail.mil; sjchung@alum.mit.edu
FU ARCS Illinois; National Science Foundation [1253758, 1427111]
FX This work was supported in part by ARCS Illinois and National Science
Foundation grants 1253758 & 1427111.
NR 12
TC 0
Z9 0
U1 3
U2 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0167-6911
EI 1872-7956
J9 SYST CONTROL LETT
JI Syst. Control Lett.
PD OCT
PY 2016
VL 96
BP 103
EP 109
DI 10.1016/j.sysconle.2016.07.008
PG 7
WC Automation & Control Systems; Operations Research & Management Science
SC Automation & Control Systems; Operations Research & Management Science
GA DY0LK
UT WOS:000384788100015
ER
PT J
AU Pope, BD
Warren, CR
Parker, KK
Cowan, CA
AF Pope, Benjamin D.
Warren, Curtis R.
Parker, Kevin Kit
Cowan, Chad A.
TI Microenvironmental Control of Adipocyte Fate and Function
SO TRENDS IN CELL BIOLOGY
LA English
DT Review
ID MESENCHYMAL STEM-CELLS; WHITE ADIPOSE-TISSUE; IN-VITRO MODEL;
EXTRACELLULAR-MATRIX; INSULIN-RESISTANCE; CULTURE-SYSTEM; METABOLIC
SYNDROME; ADIPOGENIC DIFFERENTIATION; INHIBITS ADIPOGENESIS;
LIPOPROTEIN-LIPASE
AB The properties of tissue-specific microenvironments vary widely in the human body and demonstrably influence the structure and function of many cell types. Adipocytes are no exception, responding to cues in specialized niches to perform vital metabolic and endocrine functions. The adipose microenvironment is remodeled during tissue expansion to maintain the structural and functional integrity of the tissue and disrupted remodeling in obesity contributes to the progression of metabolic syndrome, breast cancer, and other malignancies. The increasing incidence of these obesity-related diseases and the recent focus on improved in vitro models of human tissue biology underscore growing interest in the regulatory role of adipocyte microenvironments in health and disease.
C1 [Pope, Benjamin D.; Parker, Kevin Kit] Harvard Univ, John A Paulson Sch Engn & Appl Sci, Wyss Inst Biol Inspired Engn, Dis Biophys Grp,Harvard Stem Cell Inst, Cambridge, MA 02138 USA.
[Cowan, Chad A.] Harvard Univ, Harvard Stem Cell Inst, Harvard Dept Stem Cell & Regenerat Biol, Cambridge, MA 02138 USA.
[Parker, Kevin Kit] US Mil Acad, Dept Math Sci, West Point, NY 10996 USA.
[Cowan, Chad A.] Massachusetts Gen Hosp, Ctr Regenerat Med, Boston, MA 02114 USA.
RP Cowan, CA (reprint author), Harvard Univ, Harvard Stem Cell Inst, Harvard Dept Stem Cell & Regenerat Biol, Cambridge, MA 02138 USA.; Cowan, CA (reprint author), Massachusetts Gen Hosp, Ctr Regenerat Med, Boston, MA 02114 USA.
EM chad_cowan@harvard.edu
FU Harvard Stem Cell Institute; National Institutes of Health [U01HL100408,
U01HL107440, R01DK095384, R01DK097768, UC4DK104165]
FX We wish to thank Karaghen Hudson for illustrating Figure 2. We
acknowledge the financial support of the Harvard Stem Cell Institute and
National Institutes of Health grants U01HL100408, U01HL107440,
R01DK095384, and R01DK097768 to C.A.C. and UC4DK104165 to K.K.P.
NR 144
TC 1
Z9 1
U1 13
U2 13
PU ELSEVIER SCIENCE LONDON
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 0962-8924
J9 TRENDS CELL BIOL
JI Trends Cell Biol.
PD OCT
PY 2016
VL 26
IS 10
BP 745
EP 755
DI 10.1016/j.tcb.2016.05.005
PG 11
WC Cell Biology
SC Cell Biology
GA DY0HM
UT WOS:000384777900004
PM 27268909
ER
PT J
AU Williams, CL
Neu, HM
Gilbreath, JJ
Michel, SLJ
Zurawski, DV
Merrell, DS
AF Williams, Caitlin L.
Neu, Heather M.
Gilbreath, Jeremy J.
Michel, Sarah L. J.
Zurawski, Daniel V.
Merrell, D. Scott
TI Copper Resistance of the Emerging Pathogen Acinetobacter baumannii
SO APPLIED AND ENVIRONMENTAL MICROBIOLOGY
LA English
DT Article
ID INTENSIVE-CARE-UNIT; BLOOD-STREAM INFECTIONS; ESCHERICHIA-COLI;
MYCOBACTERIUM-TUBERCULOSIS; ANTIMICROBIAL ACTIVITY;
PSEUDOMONAS-AERUGINOSA; ANTIBIOTIC-RESISTANCE; NOSOCOMIAL PATHOGENS;
ACQUIRED INFECTIONS; BIOFILM FORMATION
AB Acinetobacter baumannii is an important emerging pathogen that is capable of causing many types of severe infection, especially in immunocompromised hosts. Since A. baumannii can rapidly acquire antibiotic resistance genes, many infections are on the verge of being untreatable, and novel therapies are desperately needed. To investigate the potential utility of copper-based antibacterial strategies against Acinetobacter infections, we characterized copper resistance in a panel of recent clinical A. baumannii isolates. Exposure to increasing concentrations of copper in liquid culture and on solid surfaces resulted in dose-dependent and strain-dependent effects; levels of copper resistance varied broadly across isolates, possibly resulting from identified genotypic variation among strains. Examination of the growth-phase-dependent effect of copper on A. baumannii revealed that resistance to copper increased dramatically in stationary phase. Moreover, A. baumannii biofilms were more resistant to copper than planktonic cells but were still susceptible to copper toxicity. Exposure of bacteria to subinhibitory concentrations of copper allowed them to better adapt to and grow in high concentrations of copper; this copper tolerance response is likely achieved via increased expression of copper resistance mechanisms. Indeed, genomic analysis revealed numerous putative copper resistance proteins that share amino acid homology to known proteins in Escherichia coli and Pseudomonas aeruginosa. Transcriptional analysis revealed significant upregulation of these putative copper resistance genes following brief copper exposure. Future characterization of copper resistance mechanisms may aid in the search for novel antibiotics against Acinetobacter and other highly antibiotic-resistant pathogens.
IMPORTANCE
Acinetobacter baumannii causes many types of severe nosocomial infections; unfortunately, some isolates have acquired resistance to almost every available antibiotic, and treatment options are incredibly limited. Copper is an essential nutrient but becomes toxic at high concentrations. The inherent antimicrobial properties of copper give it potential for use in novel therapeutics against drug-resistant pathogens. We show that A. baumannii clinical isolates are sensitive to copper in vitro, both in liquid and on solid metal surfaces. Since bacterial resistance to copper is mediated though mechanisms of efflux and detoxification, we identified genes encoding putative copper-related proteins in A. baumannii and showed that expression of some of these genes is regulated by the copper concentration. We propose that the antimicrobial effects of copper may be beneficial in the development of future therapeutics that target multidrug-resistant bacteria.
C1 [Williams, Caitlin L.; Gilbreath, Jeremy J.; Merrell, D. Scott] Uniformed Serv Univ Hlth Sci, Dept Microbiol & Immunol, Bethesda, MD 20814 USA.
[Neu, Heather M.; Michel, Sarah L. J.] Univ Maryland, Sch Pharm, Dept Pharmaceut Sci, Baltimore, MD 21201 USA.
[Zurawski, Daniel V.] Walter Reed Army Inst Res, Bacterial Dis Branch, Wound Infect Dept, Silver Spring, MD USA.
[Gilbreath, Jeremy J.] BioFire Diagnost LLC, Salt Lake City, UT USA.
RP Merrell, DS (reprint author), Uniformed Serv Univ Hlth Sci, Dept Microbiol & Immunol, Bethesda, MD 20814 USA.
EM douglas.merrell@usuhs.edu
RI Zurawski, Daniel/B-6578-2009
OI Zurawski, Daniel/0000-0002-7920-5601
FU National Institutes of Health (NIH); Department of Defense (DoD);
National Science Foundation (NSF) [CHE1306208]; Military Infectious
Diseases Research Program
FX Research in the laboratory of D.S.M. is supported by funding from the
National Institutes of Health (NIH) and the Department of Defense (DoD).
S.L.J.M. thanks the National Science Foundation (NSF) (grant
CHE1306208). Research in the laboratory of D.V.Z. is supported by grants
from the Military Infectious Diseases Research Program.
NR 62
TC 0
Z9 0
U1 11
U2 11
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0099-2240
EI 1098-5336
J9 APPL ENVIRON MICROB
JI Appl. Environ. Microbiol.
PD OCT
PY 2016
VL 82
IS 20
BP 6174
EP 6188
DI 10.1128/AEM.01813-16
PG 15
WC Biotechnology & Applied Microbiology; Microbiology
SC Biotechnology & Applied Microbiology; Microbiology
GA DX5RP
UT WOS:000384439700011
PM 27520808
ER
PT J
AU Srikiatkhachorn, A
Alera, MT
Lago, CB
Tac-An, IA
Villa, D
Fernandez, S
Thaisomboonsuk, B
Klungthong, C
Levy, JW
Velasco, JM
Roque, VG
Nisalak, A
Macareo, LR
Yoon, IK
AF Srikiatkhachorn, Anon
Alera, Maria Theresa
Lago, Catherine B.
Tac-An, Ilya A.
Villa, Daisy
Fernandez, Stefan
Thaisomboonsuk, Butsaya
Klungthong, Chonticha
Levy, Jens W.
Velasco, John Mark
Roque, Vito G., Jr.
Nisalak, Ananda
Macareo, Louis R.
Yoon, In-Kyu
TI Resolution of a Chikungunya Outbreak in a Prospective Cohort, Cebu,
Philippines, 2012-2014
SO EMERGING INFECTIOUS DISEASES
LA English
DT Letter
ID SEROPREVALENCE SURVEY; VIRUS
C1 [Srikiatkhachorn, Anon] Univ Rhode Isl, 825 Chalkstone Ave, Providence, RI 02908 USA.
[Alera, Maria Theresa; Lago, Catherine B.] Armed Forces Res Inst Med Sci, Virol Res Unit, Cebu, Philippines.
[Tac-An, Ilya A.; Villa, Daisy] Cebu City Hlth Dept, Cebu, Philippines.
[Fernandez, Stefan; Thaisomboonsuk, Butsaya; Klungthong, Chonticha; Levy, Jens W.; Velasco, John Mark; Nisalak, Ananda; Macareo, Louis R.; Yoon, In-Kyu] Armed Forces Res Inst Med Sci, Bangkok, Thailand.
[Roque, Vito G., Jr.] Natl Epidemiol Ctr, Philippines Dept Hlth, Manila, Philippines.
[Yoon, In-Kyu] Int Vaccine Inst, Seoul, South Korea.
RP Srikiatkhachorn, A (reprint author), Univ Rhode Isl, Inst Immunol & Informat, 80 Washington St,Room 302F, Providence, RI 02903 USA.
EM anons.gst@afrims.org
NR 10
TC 0
Z9 0
U1 1
U2 1
PU CENTERS DISEASE CONTROL
PI ATLANTA
PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA
SN 1080-6040
EI 1080-6059
J9 EMERG INFECT DIS
JI Emerg. Infect. Dis
PD OCT
PY 2016
VL 22
IS 10
BP 1852
EP 1854
DI 10.3201/eid2210.160729
PG 3
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA DX4YQ
UT WOS:000384387400034
PM 27649081
ER
PT J
AU Ouyang, RW
Kaplan, LM
Toniolo, A
Srivastava, M
Norman, TJ
AF Ouyang, Robin Wentao
Kaplan, Lance M.
Toniolo, Alice
Srivastava, Mani
Norman, Timothy J.
TI Parallel and Streaming Truth Discovery in Large-Scale Quantitative
Crowdsourcing
SO IEEE TRANSACTIONS ON PARALLEL AND DISTRIBUTED SYSTEMS
LA English
DT Article
DE Crowdsourcing; truth discovery; quantitative task; big data; parallel
algorithm; streaming algorithm
ID INCOMPLETE DATA; ALGORITHM
AB To enable reliable crowdsourcing applications, it is of great importance to develop algorithms that can automatically discover the truths from possibly noisy and conflicting claims provided by various information sources. In order to handle crowdsourcing applications involving big or streaming data, a desirable truth discovery algorithm should not only be effective, but also be scalable. However, with respect to quantitative crowdsourcing applications such as object counting and percentage annotation, existing truth discovery algorithms are not simultaneously effective and scalable. They either address truth discovery in categorical crowdsourcing or perform batch processing that does not scale. In this paper, we propose new parallel and streaming truth discovery algorithms for quantitative crowdsourcing applications. Through extensive experiments on real-world and synthetic datasets, we demonstrate that 1) both of them are quite effective, 2) the parallel algorithm can efficiently perform truth discovery on large datasets, and 3) the streaming algorithm processes data incrementally, and it can efficiently perform truth discovery both on large datasets and in data streams.
C1 [Ouyang, Robin Wentao] Chinese Acad Sci, Inst Comp Technol, CAS Key Lab Network Data Sci & Technol, Beijing, Peoples R China.
[Kaplan, Lance M.] US Army Res Lab, Networked Sensing Fus Branch, Adelphi, MD 20783 USA.
[Toniolo, Alice; Norman, Timothy J.] Univ Aberdeen, Dept Comp Sci, Aberdeen, Scotland.
[Srivastava, Mani] Univ Calif Los Angeles, Dept Elect Engn, Los Angeles, CA 90024 USA.
[Srivastava, Mani] Univ Calif Los Angeles, Dept Comp Sci, Los Angeles, CA 90024 USA.
RP Ouyang, RW (reprint author), Chinese Acad Sci, Inst Comp Technol, CAS Key Lab Network Data Sci & Technol, Beijing, Peoples R China.
EM ouyangwt@ict.ac.cn; lance.m.kaplan@us.army.mil; a.toniolo@abdn.ac.uk;
mbs@ucla.edu; t.j.norman@abdn.ac.uk
FU U.S. ARL; U.K. Ministry of Defense [W911NF-06-3-0001]; NSF [CNS-1213140]
FX This research is based upon work supported in part by the U.S. ARL and
U.K. Ministry of Defense under Agreement Number W911NF-06-3-0001, and by
the NSF under award CNS-1213140. Any opinions, findings and conclusions
or recommendations expressed in this material are those of the author(s)
and do not necessarily reflect the views or represent the official
policies of the NSF, the U.S. ARL, the U.S. Government, the U.K.
Ministry of Defense or the U.K. Government. The U.S. and U.K.
Governments are authorized to reproduce and distribute reprints for
Government purposes notwithstanding any copyright notation hereon. This
work was done when R. W. Ouyang was a postdoc at the University of
California, Los Angeles, CA.
NR 33
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U1 6
U2 6
PU IEEE COMPUTER SOC
PI LOS ALAMITOS
PA 10662 LOS VAQUEROS CIRCLE, PO BOX 3014, LOS ALAMITOS, CA 90720-1314 USA
SN 1045-9219
EI 1558-2183
J9 IEEE T PARALL DISTR
JI IEEE Trans. Parallel Distrib. Syst.
PD OCT 1
PY 2016
VL 27
IS 10
BP 2984
EP 2997
DI 10.1109/TPDS.2016.2515092
PG 14
WC Computer Science, Theory & Methods; Engineering, Electrical & Electronic
SC Computer Science; Engineering
GA DX2YI
UT WOS:000384239300015
ER
PT J
AU Xu, C
Silder, A
Zhang, J
Hughes, J
Unnikrishnan, G
Reifman, J
Rakesh, V
AF Xu, Chun
Silder, Amy
Zhang, Ju
Hughes, Julie
Unnikrishnan, Ginu
Reifman, Jaques
Rakesh, Vineet
TI An Integrated Musculoskeletal-Finite-Element Model to Evaluate Effects
of Load Carriage on the Tibia During Walking
SO JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME
LA English
DT Article
DE stress fracture; tibial stress and strain; finite-element analysis; gait
mechanics
ID VIVO STRAIN-MEASUREMENTS; IN-VIVO; STRESS-FRACTURES; TRABECULAR BONE;
MUSCLE-ACTIVITY; LOWER-EXTREMITY; FORCES; KNEE; JOINT; INJURIES
AB Prior studies have assessed the effects of load carriage on the tibia. Here, we expand on these studies and investigate the effects of load carriage on joint reaction forces (JRFs) and the resulting spatiotemporal stress/strain distributions in the tibia. Using full-body motion and ground reaction forces from a female subject, we computed joint and muscle forces during walking for four load carriage conditions. We applied these forces as physiological loading conditions in a finite-element (FE) analysis to compute strain and stress. We derived material properties from computed tomography (CT) images of a sex-, age-, and body mass index-matched subject using a mesh morphing and mapping algorithm, and used them within the FE model. Compared to walking with no load, the knee JRFs were the most sensitive to load carriage, increasing by as much as 26.2% when carrying a 30% of body weight (BW) load (ankle: 16.4% and hip: 19.0%). Moreover, our model revealed disproportionate increases in internal JRFs with increases in load carriage, suggesting a coordinated adjustment in the musculature functions in the lower extremity. FE results reflected the complex effects of spatially varying material properties distribution and muscular engagement on tibial biomechanics during walking. We observed high stresses on the anterior crest and the medial surface of the tibia at pushoff, whereas high cumulative stress during one walking cycle was more prominent in the medioposterior aspect of the tibia. Our findings reinforce the need to include: (1) physiologically accurate loading conditions when modeling healthy subjects undergoing short-term exercise training and (2) the duration of stress exposure when evaluating stress-fracture injury risk. As a fundamental step toward understanding the instantaneous effect of external loading, our study presents a means to assess the relationship between load carriage and bone biomechanics.
C1 [Xu, Chun; Unnikrishnan, Ginu; Rakesh, Vineet] US Army Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Dept Def Biotechnol High Performance Comp, Software Applicat Inst, Ft Detrick, MD 21702 USA.
[Silder, Amy] Stanford Univ, Dept Bioengn, Stanford, CA 94305 USA.
[Zhang, Ju] Univ Auckland, Auckland Bioengn Inst, Auckland 1010, New Zealand.
[Hughes, Julie] US Army Res Inst Environm Med, Natick, MA 01760 USA.
[Reifman, Jaques] US Army Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Dept Def Biotechnol High Performance Comp, Software Applicat Inst,MCMR TT, 504 Scott St, Ft Detrick, MD 21702 USA.
RP Reifman, J (reprint author), US Army Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Dept Def Biotechnol High Performance Comp, Software Applicat Inst,MCMR TT, 504 Scott St, Ft Detrick, MD 21702 USA.
EM jaques.reifman.civ@mail.mil
FU U.S. Army Network Science Initiative; Defense Health Program
FX This research was sponsored by the U.S. Army Network Science Initiative
and a grant from the Defense Health Program managed by the Military
Operational Medicine Research Program, U.S. Army Medical Research and
Materiel Command, Fort Detrick, MD. High-performance computing resources
were made available by the U.S. Department of Defense High Performance
Computing Modernization Program.
NR 52
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Z9 0
U1 6
U2 6
PU ASME
PI NEW YORK
PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA
SN 0148-0731
EI 1528-8951
J9 J BIOMECH ENG-T ASME
JI J. Biomech. Eng.-Trans. ASME
PD OCT
PY 2016
VL 138
IS 10
AR 101001
DI 10.1115/1.4034216
PG 11
WC Biophysics; Engineering, Biomedical
SC Biophysics; Engineering
GA DW9ML
UT WOS:000383984000001
ER
PT J
AU Johnston, DI
Chisty, Z
Gross, JE
Park, SY
AF Johnston, D. I.
Chisty, Z.
Gross, J. E.
Park, S. Y.
TI Investigation of Mycobacterium abscessus outbreak among cystic fibrosis
patients, Hawaii 2012
SO JOURNAL OF HOSPITAL INFECTION
LA English
DT Letter
ID DISEASE; COHORT
C1 [Johnston, D. I.; Park, S. Y.] Hawaii Dept Hlth, Dis Outbreak Control Div, Honolulu, HI USA.
[Chisty, Z.] Hawaii Dept Hlth, Dis Invest Branch, Honolulu, HI USA.
[Gross, J. E.] Tripler Army Med Ctr, Div Pulmonol, Dept Pediat, Honolulu, HI 96859 USA.
RP Johnston, DI (reprint author), Dis Outbreak Control Div, 1250 Punchbowl St RM 443, Honolulu, HI 96813 USA.
EM david.johnston@doh.hawaii.gov
NR 6
TC 1
Z9 1
U1 1
U2 1
PU W B SAUNDERS CO LTD
PI LONDON
PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND
SN 0195-6701
EI 1532-2939
J9 J HOSP INFECT
JI J. Hosp. Infect.
PD OCT
PY 2016
VL 94
IS 2
BP 198
EP 200
DI 10.1016/j.jhin.2016.04.015
PG 4
WC Infectious Diseases
SC Infectious Diseases
GA DW9NG
UT WOS:000383986400023
PM 27238609
ER
PT J
AU Stemper, BD
Corner, BD
AF Stemper, Brian D.
Corner, Brian D.
TI Whiplash-Associated Disorders: Occupant Kinematics and Neck Morphology
SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY
LA English
DT Article
DE biomechanics; car; cervical spine; collision
ID FACET JOINT KINEMATICS; MULTILEVEL CERVICAL LAMINECTOMY; AUTOMOTIVE REAR
IMPACTS; LUMBAR ANULUS FIBROSUS; SPINAL DEFORMITY; PROGNOSTIC-FACTORS;
FEMALE VOLUNTEERS; PAIN PATTERNS; RISK-FACTORS; INJURY
AB Despite considerable research effort, the incidence of whiplash injury during automotive collisions has continued to rise. This is due, at least in part, to a limited recognition of biomechanical injury mechanisms and factors influencing injury risk. While automotive safety modifications reduced injury risk in some cases, impact on the overall whiplash incidence was limited. This is likely attributable to significant occupant-related differences that have a profound impact on injury risk. Many of those differences were outlined in research studies, and examples include female sex and the associated sex based anthropometrical variation that can affect seating orientation; cervical spinal posture; and anatomical attributes, including cervical column slenderness and neck muscle morphometry. This review highlights these anatomical attributes and explains, based on biomechanical concepts, the method by which these attributes may alter cervical spine response during automotive rear impacts to affect injury risk. The biomechanical explanations are based on existing studies that have incorporated postmortem human subjects, computational models, and anthropomorphic test devices (ie, crash test dummies), as well as medical imaging in human volunteers. These biomechanical explanations may provide improved understanding of injury risk.
C1 [Stemper, Brian D.] Med Coll Wisconsin, Dept Neurosurg, 5000 West Natl Ave,Res 151, Milwaukee, WI 53226 USA.
[Stemper, Brian D.] Clement J Zablocki Vet Affairs Med Ctr, Milwaukee, WI USA.
[Corner, Brian D.] US Army, Warfighter Directorate, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA.
RP Stemper, BD (reprint author), Med Coll Wisconsin, Dept Neurosurg, 5000 West Natl Ave,Res 151, Milwaukee, WI 53226 USA.
EM bstemper@mcw.edu
NR 115
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U1 4
U2 4
PU J O S P T
PI ALEXANDRIA
PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA
SN 0190-6011
EI 1938-1344
J9 J ORTHOP SPORT PHYS
JI J. Orthop. Sports Phys. Ther.
PD OCT
PY 2016
VL 46
IS 10
BP 834
EP 844
DI 10.2519/jospt.2016.6846
PG 11
WC Orthopedics; Rehabilitation; Sport Sciences
SC Orthopedics; Rehabilitation; Sport Sciences
GA DX5CW
UT WOS:000384398400005
PM 27690838
ER
PT J
AU Linnstaedt, SD
Riker, KD
Walker, MG
Nyland, JE
Zimny, E
Lewandowski, C
Hendry, PL
Damiron, K
Pearson, C
Velilla, MA
Jones, J
Swor, RA
Domeier, R
McLean, SA
AF Linnstaedt, Sarah D.
Riker, Kyle D.
Walker, Margaret G.
Nyland, Jennifer E.
Zimny, Erin
Lewandowski, Christopher
Hendry, Phyllis L.
Damiron, Kathia
Pearson, Claire
Velilla, Marc-Anthony
Jones, Jeffrey
Swor, Robert A.
Domeier, Robert
McLean, Samuel A.
TI MicroRNA 320a Predicts Chronic Axial and Widespread Pain Development
Following Motor Vehicle Collision in a Stress-Dependent Manner
SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY
LA English
DT Article
DE cervical spine; WAD; whiplash
ID WHIPLASH-ASSOCIATED DISORDERS; PERITRAUMATIC DISTRESS INVENTORY;
RANDOMIZED CONTROLLED-TRIAL; MUSCULOSKELETAL PAIN; ETHNIC-DIFFERENCES;
GENE-EXPRESSION; POLYMORPHISMS; FIBROMYALGIA; FKBP5; SEX
AB STUDY DESIGN: Prospective human cohort study combined with molecular studies.
BACKGROUND: A microRNA is a small, noncoding RNA molecule that can play a role in disease onset. Recent studies found that circulating levels of microRNA 320a (miR-320a) are associated with musculoskeletal pain conditions and that miR-320a is stress responsive.
OBJECTIVES: To investigate whether circulating expression levels of miR-320a in the peritraumatic period predict persistent axial musculoskeletal pain 6 months after motor vehicle collision (MVC).
METHODS: We evaluated whether (1) circulating miR-320a and related members of the miR-320a family predict axial musculoskeletal pain and other musculoskeletal pain outcomes 6 months following MVC, and (2) miR-320a regulates stress system and pain-related transcripts in cell culture. Given the wealth of data suggesting that biological mechanisms influencing pain outcomes are often sex and/or stress dependent, interactions between miR-320a, stress, and sex were evaluated.
RESULTS: In primary analyses (n = 69), a significant crossover interaction was observed between the influence of circulating miR-320a and peritraumatic distress (beta = -0.01, P = .002) on post-MVC axial musculoskeletal pain. Reduced peritraumatic miR-320a expression levels predicted axial musculoskeletal pain in distressed individuals (beta = -0.12, P = .006) but not nondistressed individuals. In secondary analyses, miR-320a predicted widespread musculoskeletal pain, and related members of the miR-320a family also predicted axial and widespread musculoskeletal pain. In cell culture, miR-320a bound stress and pain-associated 3'UTR transcripts (FKBP5, ADCYAP1, PER2, and NR3C1).
CONCLUSION: These data suggest that miR-320a may help mediate regional and widespread changes in pain sensitivity after MVC.
C1 [Linnstaedt, Sarah D.; Riker, Kyle D.; Walker, Margaret G.; McLean, Samuel A.] Univ N Carolina, Dept Anesthesiol, TRYUMPH Res Program, Chapel Hill, NC USA.
[Linnstaedt, Sarah D.; Riker, Kyle D.; Walker, Margaret G.; McLean, Samuel A.] Univ N Carolina, Dept Anesthesiol, Chapel Hill, NC USA.
[Nyland, Jennifer E.] US Army, Inst Surg Res, Dept Battlefield Pain Res, San Antonio, TX USA.
[Zimny, Erin; Lewandowski, Christopher] Henry Ford Hosp, Dept Emergency Med, Detroit, MI 48202 USA.
[Hendry, Phyllis L.] Univ Florida, Coll Med, Dept Emergency Med, Jacksonville, FL USA.
[Damiron, Kathia] Albert Einstein Med Ctr, Dept Emergency Med, Philadelphia, PA 19141 USA.
[Pearson, Claire] Detroit Receiving, Dept Emergency Med, Detroit, MI USA.
[Velilla, Marc-Anthony] Sinai Grace Hosp, Dept Emergency Med, Detroit, MI USA.
[Jones, Jeffrey] Spectrum Hlth Butterworth Campus, Dept Emergency Med, Grand Rapids, MI USA.
[Swor, Robert A.] William Beaumont Hosp, Dept Emergency Med, Royal Oak, MI 48072 USA.
[Domeier, Robert] St Joseph Mercy Hlth Syst, Dept Emergency Med, Ypsilanti, MI USA.
[McLean, Samuel A.] Univ N Carolina, Dept Emergency Med, Chapel Hill, NC USA.
RP Linnstaedt, SD (reprint author), Univ N Carolina, Med Sch Wing C,CB 7010, Chapel Hill, NC 27599 USA.
EM slinnstaedt@aims.unc.edu
FU National Institute of Arthritis, Musculoskeletal and Skin Diseases
[R01AR060852]; Mayday Fund; US Army Medical Research and Materiel
Command Combat Casualty Care Research; Clinical and Rehabilitative
Medicine Research programs
FX Methods were approved by The University of North Carolina at Chapel Hill
Biomedical Institutional Review Board (study number 11-1742). Funding
for this study was provided by the National Institute of Arthritis,
Musculoskeletal and Skin Diseases (grant R01AR060852 to Dr McLean) and
The Mayday Fund. Neither of the above funding agencies had any role in
the design and conduct of the study; in the collection, management,
analysis, and interpretation of the data; or in the preparation, review,
or approval of the manuscript. Funding was also supported by the US Army
Medical Research and Materiel Command Combat Casualty Care Research and
the Clinical and Rehabilitative Medicine Research programs. The opinions
or assertions contained herein are the private views of the authors and
are not to be construed as official or as reflecting the views of the
Department of the Army or the Department of Defense. The authors certify
that they have no affiliations with or financial involvement in any
organization or entity with a direct financial interest in the subject
matter or materials discussed in the article.
NR 55
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U1 1
U2 1
PU J O S P T
PI ALEXANDRIA
PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA
SN 0190-6011
EI 1938-1344
J9 J ORTHOP SPORT PHYS
JI J. Orthop. Sports Phys. Ther.
PD OCT
PY 2016
VL 46
IS 10
BP 911
EP 919
DI 10.2519/jospt.2016.6944
PG 9
WC Orthopedics; Rehabilitation; Sport Sciences
SC Orthopedics; Rehabilitation; Sport Sciences
GA DX5CW
UT WOS:000384398400013
PM 27690835
ER
PT J
AU Riebel, M
Westrick, R
Goss, D
AF Riebel, Mark
Westrick, Richard
Goss, Donald
TI Unstable Os Odontoideum
SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY
LA English
DT Editorial Material
C1 [Riebel, Mark; Goss, Donald] Keller Army Community Hosp, West Point, NY 10996 USA.
[Westrick, Richard] US Army, Environm Med Res Inst, Natick, MA 01760 USA.
RP Riebel, M (reprint author), Keller Army Community Hosp, West Point, NY 10996 USA.
NR 3
TC 0
Z9 0
U1 0
U2 0
PU J O S P T
PI ALEXANDRIA
PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA
SN 0190-6011
EI 1938-1344
J9 J ORTHOP SPORT PHYS
JI J. Orthop. Sports Phys. Ther.
PD OCT
PY 2016
VL 46
IS 10
BP 930
EP 930
DI 10.2519/jospt.2016.0417
PG 1
WC Orthopedics; Rehabilitation; Sport Sciences
SC Orthopedics; Rehabilitation; Sport Sciences
GA DX5CW
UT WOS:000384398400016
PM 27690833
ER
PT J
AU Heifert, TA
Susi, A
Hisle-Gorman, E
Erdie-Lalena, CR
Gorman, G
Min, SB
Nylund, CM
AF Heifert, Theresa A.
Susi, Apryl
Hisle-Gorman, Elizabeth
Erdie-Lalena, Christine R.
Gorman, Gregory
Min, Steve B.
Nylund, Cade M.
TI Feeding Disorders in Children With Autism Spectrum Disorders Are
Associated With Eosinophilic Esophagitis
SO JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
LA English
DT Article
DE absolute eosinophil count; autism; child developmental disorders;
eosinophilic esophagitis; feeding and eating disorders of childhood
ID GASTROINTESTINAL SYMPTOMS; CONSENSUS RECOMMENDATIONS; HEALTH; ASD;
METAANALYSIS; COMORBIDITY; DYSFUNCTION; PREVALENCE; EXPERIENCE;
CHILDHOOD
AB Objectives: Eosinophilic esophagitis (EoE) can present as food selectivity or feeding disorders in children. Children with autism spectrum disorders (ASDs) commonly demonstrate behavioral food selectivity in type and texture, which often leads to the diagnosis of feeding disorder. We sought to evaluate the association of ASD with EoE.
Methods: A retrospective matched case-cohort study was performed using the Military Health System database from October 2008 to September 2013. We performed a 1: 5 case-control match by age, sex, and enrollment timeframe. Feeding disorders, EoE, and atopic disorders were defined using diagnostic and procedure codes.
Results: There were 45,286 children with ASD and 226,430 matched controls. EoE was more common in children with ASD (0.4%) compared with controls (0.1%). Feeding disorders were associated with EoE in both children with ASD and controls. Feeding disorders also had a higher odds ratio for EoE compared with other atopic conditions, among both children with ASD (7.17, 95% confidence interval [CI] 4.87-10.5) and controls (11.5, 95% CI 7.57-17.5). Compared with controls with a feeding disorder, children with ASD and a feeding disorder had no difference in the rate of diagnosed EoE (0.85, 0.95% CI 0.39-1.88).
Conclusions: Children with ASD are more likely to be diagnosed with EoE compared with controls; however, among children with feeding disorders, there is no difference in the odds of EoE. A diagnosis of feeding disorder was strongly associated with EoE. Feeding disorders in children with ASD should not be assumed to be solely behavioral and an esophagogastroduodenoscopy should be performed to evaluate for EoE.
C1 [Heifert, Theresa A.; Susi, Apryl; Hisle-Gorman, Elizabeth; Gorman, Gregory; Nylund, Cade M.] Uniformed Serv Univ Hlth Sci, Dept Pediat, Bethesda, MD USA.
[Heifert, Theresa A.] Womack Army Med Ctr, Dept Pediat, 2817 Riley Rd, Ft Bragg, NC 28310 USA.
[Erdie-Lalena, Christine R.; Min, Steve B.] Walter Reed Natl Mil Med Ctr, Dept Pediat, Bethesda, MD USA.
RP Heifert, TA (reprint author), Womack Army Med Ctr, Dept Pediat, 2817 Riley Rd, Ft Bragg, NC 28310 USA.
EM theresa.a.heifert.mil@mail.mil
FU Congressional Directed Medical Research Programs, Autism
[W81XWH-12-2-0066]
FX The study was conducted with support from the Congressional Directed
Medical Research Programs, Autism Research Award W81XWH-12-2-0066.
NR 43
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U1 4
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0277-2116
EI 1536-4801
J9 J PEDIATR GASTR NUTR
JI J. Pediatr. Gastroenterol. Nutr.
PD OCT
PY 2016
VL 63
IS 4
BP E69
EP E73
DI 10.1097/MPG.0000000000001282
PG 5
WC Gastroenterology & Hepatology; Nutrition & Dietetics; Pediatrics
SC Gastroenterology & Hepatology; Nutrition & Dietetics; Pediatrics
GA DX4NP
UT WOS:000384358700005
PM 27276430
ER
PT J
AU Kittikraisak, W
Suntarattiwong, P
Ditsungnoen, D
Klungthong, C
Fernandez, S
Yoon, IK
Lindblade, K
Dawood, FS
Olsen, SJ
Chotpitayasunondh, T
AF Kittikraisak, Wanitchaya
Suntarattiwong, Piyarat
Ditsungnoen, Darunee
Klungthong, Chonticha
Fernandez, Stefan
Yoon, In-Kyu
Lindblade, Kim
Dawood, Fatimah S.
Olsen, Sonja J.
Chotpitayasunondh, Tawee
TI Effectiveness of the 2013 and 2014 Southern Hemisphere Influenza
Vaccines Against Laboratory-confirmed Influenza in Young Children Using
a Test-negative Design, Bangkok, Thailand
SO PEDIATRIC INFECTIOUS DISEASE JOURNAL
LA English
DT Article
DE influenza; vaccination; effectiveness; Thailand; children
ID IMMUNIZATION PRACTICES; ADVISORY-COMMITTEE; SEASONAL INFLUENZA;
UNITED-STATES; VACCINATION; RECOMMENDATIONS; SURVEILLANCE; INFECTIONS;
PREVENTION; COVERAGE
AB Background: The Thai Advisory Committee on Immunization Practices recommends annual influenza vaccination for children 6 months through 2 years of age, although older children may be vaccinated on request. We evaluated the effectiveness of the 2013 and 2014 inactivated influenza vaccines to reduce medically attended, laboratory-confirmed influenza illness among Thai children aged 7-60 months.
Methods: From September 2013-May 2015, children with influenza-like illness were screened with a rapid influenza diagnostic test. Enrolled children had nasal and throat swabs tested for influenza viruses using polymerase chain reaction. Cases and controls were subjects testing positive and negative, respectively, for influenza viruses by polymerase chain reaction. Vaccination status was ascertained from vaccination cards. Vaccine effectiveness (VE) was calculated as 100% x (1 - odds ratio of vaccination among cases vs. controls).
Results: Of the 1377 children enrolled, cases (n = 490) and controls (n = 887) were similar in demographic characteristics. Cases were less likely to receive influenza vaccine than controls in 2013 (6% vs. 14%; P = 0.02), but not in 2014 (6% vs. 7%; P = 0.57). Among cases, 126 (26%) were positive for influenza A(H1N1) pdm09 virus, 239 (49%) for influenza A(H3N2) and 124 (25%) for influenza B. One specimen was positive for both influenza A(H3N2) and B viruses. VE for full vaccination against all viruses was 64% (95% confidence interval: 21% to 84%) in 2013 and 26% (95% confidence interval: -47% to 63%) in 2014.
Conclusions: Influenza vaccination was low among Thai children in this study, and VE varied by year, highlighting the need for annual monitoring of VE to better understand vaccine program effectiveness.
C1 [Kittikraisak, Wanitchaya; Ditsungnoen, Darunee; Lindblade, Kim] Thailand Minist Publ Hlth US Ctr Dis Control & Pr, Influenza Program, Nonthaburi, Thailand.
[Suntarattiwong, Piyarat; Chotpitayasunondh, Tawee] Minist Publ Hlth, Queen Sirikit Natl Inst Child Hlth, Bangkok, Thailand.
[Klungthong, Chonticha; Fernandez, Stefan] Armed Forces Res Inst Med Sci, Bangkok, Thailand.
[Yoon, In-Kyu] Int Vaccine Inst, Seoul, South Korea.
[Lindblade, Kim; Dawood, Fatimah S.; Olsen, Sonja J.] US Ctr Dis Control & Prevent, Influenza Div, Atlanta, GA USA.
RP Kittikraisak, W (reprint author), Minist Publ Hlth US Ctr Dis Control & Prevent Col, DDC Bldg 7,Tiwanon Rd, Nonthaburi 11000, Thailand.
EM glr9@cdc.gov
FU US Centers for Disease Control and Prevention [5U01GH000152]
FX Supported by US Centers for Disease Control and Prevention through
cooperative agreement 5U01GH000152.
NR 39
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U1 3
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0891-3668
EI 1532-0987
J9 PEDIATR INFECT DIS J
JI Pediatr. Infect. Dis. J.
PD OCT
PY 2016
VL 35
IS 10
BP E318
EP E325
DI 10.1097/INF.0000000000001280
PG 8
WC Immunology; Infectious Diseases; Pediatrics
SC Immunology; Infectious Diseases; Pediatrics
GA DX1KG
UT WOS:000384125600020
PM 27307102
ER
PT J
AU House, JM
AF House, Jonathan M.
TI Near and Distant Neighbors: A New History of Soviet Intelligence
SO RUSSIAN REVIEW
LA English
DT Book Review
C1 [House, Jonathan M.] US Army Command & Gen Staff Coll, Ft Leavenworth, KS 66027 USA.
RP House, JM (reprint author), US Army Command & Gen Staff Coll, Ft Leavenworth, KS 66027 USA.
NR 1
TC 0
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U1 1
U2 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0036-0341
EI 1467-9434
J9 RUSS REV
JI Russ. Rev.
PD OCT
PY 2016
VL 75
IS 4
BP 728
EP 729
PG 2
WC History
SC History
GA DW7VP
UT WOS:000383861200047
ER
PT J
AU Ramakrishnan, S
Wesensten, NJ
Kamimori, GH
Moon, JE
Balkin, TJ
Reifman, J
AF Ramakrishnan, Sridhar
Wesensten, Nancy J.
Kamimori, Gary H.
Moon, James E.
Balkin, Thomas J.
Reifman, Jaques
TI A Unified Model of Performance for Predicting the Effects of Sleep and
Caffeine
SO SLEEP
LA English
DT Article
DE biomathematical model; caffeine model; chronic sleep restriction; PVT;
total sleep deprivation
ID PSYCHOMOTOR VIGILANCE TEST; BIOMATHEMATICAL MODEL; COGNITIVE
PERFORMANCE; DEPRIVATION; IMPAIRMENT; OPERATIONS; MODAFINIL; ALERTNESS;
DEXTROAMPHETAMINE; VULNERABILITY
AB Study Objectives: Existing mathematical models of neurobehavioral performance cannot predict the beneficial effects of caffeine across the spectrum of sleep loss conditions, limiting their practical utility. Here, we closed this research gap by integrating a model of caffeine effects with the recently validated unified model of performance (UMP) into a single, unified modeling framework. We then assessed the accuracy of this new UMP in predicting performance across multiple studies.
Methods: We hypothesized that the pharmacodynamics of caffeine vary similarly during both wakefulness and sleep, and that caffeine has a multiplicative effect on performance. Accordingly, to represent the effects of caffeine in the UMP, we multiplied a dose-dependent caffeine factor (which accounts for the pharmacokinetics and pharmacodynamics of caffeine) to the performance estimated in the absence of caffeine. We assessed the UMP predictions in 14 distinct laboratory-and field-study conditions, including 7 different sleep-loss schedules (from 5 h of sleep per night to continuous sleep loss for 85 h) and 6 different caffeine doses (from placebo to repeated 200 mg doses to a single dose of 600 mg).
Results: The UMP accurately predicted group-average psychomotor vigilance task performance data across the different sleep loss and caffeine conditions (6% < error < 27%), yielding greater accuracy for mild and moderate sleep loss conditions than for more severe cases. Overall, accounting for the effects of caffeine resulted in improved predictions (after caffeine consumption) by up to 70%.
Conclusions: The UMP provides the first comprehensive tool for accurate selection of combinations of sleep schedules and caffeine countermeasure strategies to optimize neurobehavioral performance.
C1 [Ramakrishnan, Sridhar; Reifman, Jaques] US Army Med Res & Mat Command, Dept Def, Biotechnol High Performance Comp Software Applica, Telemed & Adv Technol Res Ctr, ATTN MCMR TT,504 Scott St, Ft Detrick, MD 21702 USA.
[Wesensten, Nancy J.] Air Traff Org, Fed Aviat Adm, Washington, DC USA.
[Kamimori, Gary H.; Moon, James E.; Balkin, Thomas J.] Walter Reed Army Inst Res, Behav Biol Branch, Silver Spring, MD USA.
RP Reifman, J (reprint author), US Army Med Res & Mat Command, Dept Def, Biotechnol High Performance Comp Software Applica, Telemed & Adv Technol Res Ctr, ATTN MCMR TT,504 Scott St, Ft Detrick, MD 21702 USA.
EM jaques.reifman.civ@mail.mil
FU Military Operational Medicine Research Area Directorate of the U.S. Army
Medical Research and Materiel Command, Ft. Detrick, MD; US Department of
Defense Medical Research and Development Program [DMRDP_13200]
FX This was not an industry-supported study. This work was sponsored by the
Military Operational Medicine Research Area Directorate of the U.S. Army
Medical Research and Materiel Command, Ft. Detrick, MD, and by the US
Department of Defense Medical Research and Development Program (Grant
No. DMRDP_13200). The authors have indicated no financial conflicts of
interest. The opinions and assertions contained herein are the private
views of the authors and are not to be construed as official or as
reflecting the views of the US Army or of the US Department of Defense.
This paper has been approved for public release with unlimited
distribution.
NR 32
TC 1
Z9 1
U1 8
U2 8
PU AMER ACAD SLEEP MEDICINE
PI WESTCHESTER
PA ONE WESTBROOK CORPORATE CTR, STE 920, WESTCHESTER, IL 60154 USA
SN 0161-8105
EI 1550-9109
J9 SLEEP
JI Sleep
PD OCT 1
PY 2016
VL 39
IS 10
BP 1827
EP 1841
DI 10.5665/sleep.6164
PG 15
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA DX4ET
UT WOS:000384334700008
PM 27397562
ER
PT J
AU Martin, RF
AF Martin, Ronald F.
TI New Trends in the Treatment of Sarcoma Foreword
SO SURGICAL CLINICS OF NORTH AMERICA
LA English
DT Editorial Material
C1 [Martin, Ronald F.] US Army Reserve, York Hosp, 16 Hosp Dr,Suite A, York, ME 03909 USA.
EM rmartin@yorkhospital.com
NR 0
TC 0
Z9 0
U1 0
U2 0
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0039-6109
EI 1558-3171
J9 SURG CLIN N AM
JI Surg. Clin.-North Am.
PD OCT
PY 2016
VL 96
IS 5
BP XIII
EP XIV
DI 10.1016/j.suc.2016.07.017
PG 2
WC Surgery
SC Surgery
GA DW4TY
UT WOS:000383637100001
ER
PT J
AU Zhou, L
Giri, A
Cho, K
Sohn, Y
AF Zhou, Le
Giri, Anit
Cho, Kyu
Sohn, Yongho
TI Mechanical anomaly observed in Ni-Mn-Ga alloys by nanoindentation
SO ACTA MATERIALIA
LA English
DT Article
DE Ni-Mn-Ga; Nanoindentation; Modulus and hardness; Martensitic
transformation
ID FIELD-INDUCED STRAIN; SHAPE-MEMORY ALLOYS; ELASTIC PROPERTIES;
MARTENSITIC-TRANSFORMATION; NI2MNGA; PHASE; TEMPERATURE; INDENTATION;
HARDNESS; MODULUS
AB Reduced elastic modulus (E-r) and hardness (H) for NiMnGa alloys were investigated using nano indentation over a large compositional range generated via diffusion couple annealing. Diffusion couples were assembled from selected starting alloys and annealed at 900 degrees C for 120 h. Compositions generated through diffusion couples, as examined by electron probe micro-analyzer, covered large part of the beta phase region. Microstructural analyses by scanning electron microscopy revealed that, for each diffusion couple, an interface separating austenite and martensite was created due to variation of the martensitic transformation temperature at different compositions. Nanoindentation measurements were carried out across the interdiffusion zone for each diffusion couple, and a correspondence between E-r or H and composition is established. The measured E-r and H had larger scatter for the martensitic phase than for the austenitic phase. A decrease of E-r and H was observed with Mn or Ni substituting for Ga, and Ni substituting for Mn in the austenitic phase. However, an opposite trend was found in the martensitic phase: an increase of E-r and H was observed with Mn or Ni substituting for Ga, and Ni substituting for Mn. A minimum value of E-r and H was always observed near the interface between austenite and martensite. The softening of the elastic constants due to pre-martensitic transformation contributed to the sharp decreases in E-r and H near the interface region. The results demonstrate that the influence of lattice softening is significant over a large compositional range on the mechanical properties of NiMnGa alloys and potentially in other materials that have a martensitic transformation. (C) 2016 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
C1 [Zhou, Le; Sohn, Yongho] Univ Cent Florida, Dept Mat Sci & Engn, Orlando, FL 32816 USA.
[Zhou, Le; Sohn, Yongho] Univ Cent Florida, Adv Mat Proc & Anal Ctr, Orlando, FL 32816 USA.
[Giri, Anit] TKC Global, 13873 Pk Ctr Rd, Herndon, VA 20171 USA.
[Giri, Anit; Cho, Kyu] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA.
RP Sohn, Y (reprint author), Univ Cent Florida, Dept Mat Sci & Engn, Orlando, FL 32816 USA.; Sohn, Y (reprint author), Univ Cent Florida, Adv Mat Proc & Anal Ctr, Orlando, FL 32816 USA.
EM Yongho.sohn@ucf.edu
RI Sohn, Yongho/A-8517-2010;
OI Sohn, Yongho/0000-0003-3723-4743; Zhou, Le/0000-0001-8327-6667
FU University of Central Florida [W911NF-11-2-0020]; U.S. Army Research
Laboratory [W911NF-11-2-0020]
FX This research was sponsored by the U.S. Army Research Laboratory through
cooperative agreement #W911NF-11-2-0020 between University of Central
Florida and the U.S. Army Research Laboratory. The views, opinions and
conclusions made in this document are those of the authors and should
not be interpreted as representing the official policies, either
expressed or implied, of the U.S. Army Research Laboratory or the U.S.
Government. The U.S. Government is authorized to reproduce and
distribute reprints for Government purposes notwithstanding any
copyright notation herein. The authors would also like to thank Mr.
Timothy Delahanty at Pittsburgh Materials Technology, Pittsburgh,
Pennsylvania, USA, for preparation of the alloys, and Mr. Thomas Beasley
at Florida International University, Miami, Florida, USA, for the
assistance with EPMA operation.
NR 48
TC 0
Z9 0
U1 16
U2 16
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 1359-6454
EI 1873-2453
J9 ACTA MATER
JI Acta Mater.
PD OCT 1
PY 2016
VL 118
BP 54
EP 63
DI 10.1016/j.actamat.2016.07.029
PG 10
WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical
Engineering
SC Materials Science; Metallurgy & Metallurgical Engineering
GA DW8WI
UT WOS:000383935800006
ER
PT J
AU Powell-Dunford, N
Bushby, A
Leland, RA
AF Powell-Dunford, Nicole
Bushby, Alaistair
Leland, Richard A.
TI Spatial Disorientation Training in the Rotor Wing Flight Simulator
SO AEROSPACE MEDICINE AND HUMAN PERFORMANCE
LA English
DT Article
DE spatial disorientation; rotor wing; flight simulator
AB BACKGROUND: This study is intended to identify efficacy, evolving applications, best practices, and challenges of spatial disorientation (SD) training in flight simulators for rotor wing pilots.
METHODS: Queries of a UK Ministry of Defense research database and Pub Med were undertaken using the search terms'spatial disorientation,' 'rotor wing,' and 'flight simulator': Efficacy, evolving applications, best practices, and challenges of SD simulation for rotor wing pilots were also ascertained through discussion with subject matter experts and industrial partners. Expert opinions were solicited at the aeromedical physiologist, aeromedical psychologist, instructor pilot, aeromedical examiner, and corporate executive levels.
RESULTS: Peer review literature search yielded 129 articles, with 5 relevant to the use of flight simulators for the spatial disorientation training of rotor wing pilots. Efficacy of such training was measured subjectively and objectively. A preponderance of anecdotal reports endorse the benefits of rotor wing simulator SD training, with a small trial substantiating performance improvement. Advancing technologies enable novel training applications. The mobile nature of flight students and concurrent anticollision technologies can make long-range assessment of SD training efficacy challenging. Costs of advanced technologies could limit the extent to which the most advanced simulators can be employed across the rotor wing community.
DISCUSSION: Evidence suggests the excellent training value of rotor wing simulators for SD training. Objective data from further research, particularly with regards to evolving technologies, may justify further usage of advanced simulator platforms for SD training and research.
C1 [Powell-Dunford, Nicole; Bushby, Alaistair; Leland, Richard A.] US Army, Aeromed Res Lab, Ft Rucker, AL USA.
RP Powell-Dunford, N (reprint author), USAARL, PSC 50,Box 827, APO, AE 09494 USA.
EM nicole.powell-dunford.mil@mail.mil
NR 11
TC 0
Z9 0
U1 4
U2 4
PU AEROSPACE MEDICAL ASSOC
PI ALEXANDRIA
PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA
SN 2375-6314
EI 2375-6322
J9 AEROSP MED HUM PERF
JI Aerosp. Med.Hum. Perform.
PD OCT
PY 2016
VL 87
IS 10
BP 890
EP 893
DI 10.3357/AMHP.4638.2016
PG 4
WC Biophysics; Public, Environmental & Occupational Health; Medicine,
Research & Experimental
SC Biophysics; Public, Environmental & Occupational Health; Research &
Experimental Medicine
GA DX0EL
UT WOS:000384034500008
PM 27662352
ER
PT J
AU Stewart, IJ
Sosnov, JA
Howard, JT
Chung, KK
AF Stewart, Ian J.
Sosnov, Jonathan A.
Howard, Jeffrey T.
Chung, Kevin K.
TI Acute Kidney Injury in Critically Injured Combat Veterans: A
Retrospective Cohort Study
SO AMERICAN JOURNAL OF KIDNEY DISEASES
LA English
DT Article
DE Acute kidney injury (AKI); trauma; combat veteran; mortality; death;
risk factors; combat; military service; war casualty; military
personnel; serum creatinine; KDIGO AKI criteria; burn injury
ID GLOMERULAR-FILTRATION-RATE; ILL TRAUMA PATIENTS; SERUM CREATININE;
MILITARY CASUALTIES; RISK-FACTORS; OUTCOMES; MORTALITY; BURNS; AKI;
FAILURE
AB Background: Acute kidney injury (AKI) has been associated with mortality after traumatic injury. However, there is a paucity of data for military service members with injuries received in combat. We sought to identify risk factors for AKI after combat trauma and evaluate whether AKI is a predictor of mortality.
Study Design: Retrospective observational study.
Settings & Participants: US service members who were critically wounded in Iraq or Afghanistan from February 1, 2002, to February 1, 2011, and survived until evacuation to Landstuhl Regional Medical Center, Germany.
Predictors: Demographic variables, vital signs, injury severity score, presence of burn injury, and mechanism of injury as defined at the time of initial injury, as well as the presence of AKI ascertained within the first 7 days using KDIGO (Kidney Disease: Improving Global Outcomes) serum creatinine criteria.
Outcomes: Logistic regression models were used to identify risk factors for both AKI and death.
Results: Of 6,011 records, 3,807 were included for analysis after excluding patients with missing data. AKI occurred in 474 (12.5%) patients and 112 (2.9%) died. More patients with versus without AKI died (n = 62 [13.1%] vs n = 50 [1.5%]; P < 0.001). After adjustment, AKI was a predictor of mortality (OR, 5.14; 95% CI, 3.33-7.93; P < 0.001). Predictors of AKI were age, African American race, injury severity score, amputations, burns, and presenting vital signs.
Limitations: AKI diagnoses limited to creatinine-based definitions.
Conclusions: AKI predicted mortality in combat veterans injured in the wars in Iraq and Afghanistan. Published by Elsevier Inc. on behalf of the National Kidney Foundation, Inc. This is a US Government Work. There are no restrictions on its use.
C1 [Stewart, Ian J.] David Grant Med Ctr, Clin Invest Facil, Travis AFB, CA 94535 USA.
[Stewart, Ian J.; Sosnov, Jonathan A.; Chung, Kevin K.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
[Sosnov, Jonathan A.] San Antonio Mil Med Ctr, Ft Sam Houston, TX USA.
[Howard, Jeffrey T.; Chung, Kevin K.] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
RP Stewart, IJ (reprint author), David Grant Med Ctr, Clin Invest Facil, Travis AFB, CA 94535 USA.
EM ian.stewart@us.af.mil
FU US Army Institute of Surgical Research; Oak Ridge Institute of Science
and Education
FX Support: This project was supported with intramural funds from the US
Army Institute of Surgical Research and by a postdoctoral fellowship
provided by the Oak Ridge Institute of Science and Education (Dr
Howard). The funders did not have a role in study design, data
collection, data analysis, data interpretation, manuscript preparation,
or the decision to submit for publication.
NR 28
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U1 2
U2 2
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0272-6386
EI 1523-6838
J9 AM J KIDNEY DIS
JI Am. J. Kidney Dis.
PD OCT
PY 2016
VL 68
IS 4
BP 564
EP 570
DI 10.1053/j.ajkd.2016.03.419
PG 7
WC Urology & Nephrology
SC Urology & Nephrology
GA DW8GF
UT WOS:000383892200017
PM 27155727
ER
PT J
AU Dos Santos, RF
Boedihardjo, A
Shah, S
Chen, F
Lu, CT
Ramakrishnan, N
AF Dos Santos, Raimundo F., Jr.
Boedihardjo, Arnold
Shah, Sumit
Chen, Feng
Lu, Chang-Tien
Ramakrishnan, Naren
TI The big data of violent events: algorithms for association analysis
using spatio-temporal storytelling
SO GEOINFORMATICA
LA English
DT Article
DE Spatial-temporal systems; Entity relationship modeling; Social media
networks; Spatial and physical reasoning; Semantic networks; Big Data
ID EVOLVING GRAPHS
AB This paper proposes three methods of association analysis that address two challenges of Big Data: capturing relatedness among real-world events in high data volumes, and modeling similar events that are described disparately under high data variability. The proposed methods take as input a set of geotemporally-encoded text streams about violent events called "storylines". These storylines are associated for two purposes: to investigate if an event could occur again, and to measure influence, i.e., how one event could help explain the occurrence of another. The first proposed method, Distance-based Bayesian Inference, uses spatial distance to relate similar events that are described differently, addressing the challenge of high variability. The second and third methods, Spatial Association Index and Spatio-logical Inference, measure the influence of storylines in different locations, dealing with the high-volume challenge. Extensive experiments on social unrest in Mexico and wars in the Middle East showed that these methods can achieve precision and recall as high as 80 % in retrieval tasks that use both keywords and geospatial information as search criteria. In addition, the experiments demonstrated high effectiveness in uncovering real-world storylines for exploratory analysis.
C1 [Dos Santos, Raimundo F., Jr.; Boedihardjo, Arnold] US Army Corps Engineers, Washington, DC 20314 USA.
[Shah, Sumit; Lu, Chang-Tien; Ramakrishnan, Naren] Virginia Tech, Dept Comp Sci, 7054 Haycock Rd, Falls Church, VA 22043 USA.
[Chen, Feng] SUNY Albany, Albany, NY 12222 USA.
RP Dos Santos, RF (reprint author), US Army Corps Engineers, Washington, DC 20314 USA.
EM raimundo.f.dossantos@usace.army.mil;
arnold.p.boedihardjo@usace.army.mil; sshah@vt.edu; fchen5@albany.edu;
ctlu@vt.edu; naren@vt.edu
OI Dos Santos, Ray/0000-0001-6495-803X
NR 32
TC 0
Z9 0
U1 6
U2 6
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1384-6175
EI 1573-7624
J9 GEOINFORMATICA
JI Geoinformatica
PD OCT
PY 2016
VL 20
IS 4
BP 879
EP 921
DI 10.1007/s10707-016-0247-0
PG 43
WC Computer Science, Information Systems; Geography, Physical
SC Computer Science; Physical Geography
GA DW6OA
UT WOS:000383769500013
ER
PT J
AU Thiemmeca, S
Tamdej, C
Punyadee, N
Songjang, A
Prommool, T
Noisakran, S
Puttikhunt, C
Atkinson, JP
Diamond, MS
Ponlawat, A
Avirutnan, P
AF Thiemmeca, Somchai
Tamdej, Chamaiporn
Punyadee, Nuntaya
Songjang, Adisak
Prommool, Tanapan
Noisakran, Sansanee
Puttikhunt, Chunya
Atkinson, John P.
Diamond, Michael S.
Ponlawat, Alongkot
Avirutnan, Panisadee
TI A novel strategy for complement evasion by nonstructural protein-1 of
dengue virus
SO IMMUNOBIOLOGY
LA English
DT Meeting Abstract
C1 [Thiemmeca, Somchai; Tamdej, Chamaiporn; Punyadee, Nuntaya; Songjang, Adisak; Noisakran, Sansanee; Puttikhunt, Chunya; Avirutnan, Panisadee] Mahidol Univ, Siriraj Hosp, Fac Med, Div Dengue Hemorrhag Fever Res, Bangkok, Thailand.
[Thiemmeca, Somchai] Mahidol Univ, Siriraj Hosp, Fac Med, Grad Program,Dept Immunol, Bangkok, Thailand.
[Prommool, Tanapan; Noisakran, Sansanee; Puttikhunt, Chunya; Avirutnan, Panisadee] Natl Sci & Technol Dev Agcy, Natl Ctr Genet Engn & Biotechnol, Med Biotechnol Res Unit, Bangkok, Thailand.
[Atkinson, John P.; Diamond, Michael S.] Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA.
[Atkinson, John P.; Diamond, Michael S.] Washington Univ, Sch Med, Dept Mol Microbiol, St Louis, MO 63110 USA.
[Atkinson, John P.; Diamond, Michael S.] Washington Univ, Sch Med, Dept Pathol, St Louis, MO 63110 USA.
[Atkinson, John P.; Diamond, Michael S.] Washington Univ, Sch Med, Dept Immunol, St Louis, MO USA.
[Ponlawat, Alongkot] Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok, Thailand.
NR 0
TC 0
Z9 0
U1 6
U2 6
PU ELSEVIER GMBH, URBAN & FISCHER VERLAG
PI JENA
PA OFFICE JENA, P O BOX 100537, 07705 JENA, GERMANY
SN 0171-2985
J9 IMMUNOBIOLOGY
JI Immunobiology
PD OCT
PY 2016
VL 221
IS 10
SI SI
MA 147
BP 1197
EP 1198
DI 10.1016/j.imbio.2016.06.162
PG 2
WC Immunology
SC Immunology
GA DV3ER
UT WOS:000382804300159
ER
PT J
AU Kurth, MH
Linkov, I
AF Kurth, Margaret H.
Linkov, Igor
TI Preventing Risk and Promoting Resilience in Radiation Health
SO INTEGRATED ENVIRONMENTAL ASSESSMENT AND MANAGEMENT
LA English
DT Editorial Material
DE Resilience; Risk; Policy; Decision analysis; Radiation
ID DESIGN
AB Because risk assessment is fundamentally deficient in the face of unknown or unforeseeable events and disasters such as occurred in 2011 at the Fukushima Daiichi Nuclear Power Station in Japan, resilience thinking, which focuses on the ability of both natural and human-made systems to prepare for, absorb, and recover from an adverse event and to adapt to new conditions is an important additional consideration in decision making. Radiation contamination is an impediment to most critical functions of a community; resilience planning considers how those critical functions will be maintained in the event that radiation contamination does occur. Therefore, planning should begin with resilience-based thinking and should be complemented with risk assessment-based tools. Integr Environ Assess Manag 2016;12:677-679. Published 2016. This article is a U.S. Government work and is in the public domain in the USA.
C1 [Kurth, Margaret H.; Linkov, Igor] US Army Corps Engineers, Risk & Decis Sci Team, Engn Res & Dev Ctr, Environm Lab, Concord, MA USA.
RP Linkov, I (reprint author), US Army Corps Engineers, Risk & Decis Sci Team, Engn Res & Dev Ctr, Environm Lab, Concord, MA USA.
EM Igor.Linkov@usace.army.mil
NR 18
TC 0
Z9 0
U1 6
U2 6
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1551-3777
EI 1551-3793
J9 INTEGR ENVIRON ASSES
JI Integr. Environ. Assess. Manag.
PD OCT
PY 2016
VL 12
IS 4
BP 677
EP 679
DI 10.1002/ieam.1824
PG 3
WC Environmental Sciences; Toxicology
SC Environmental Sciences & Ecology; Toxicology
GA DW0XH
UT WOS:000383365800016
PM 27447754
ER
PT J
AU Allen, JB
AF Allen, J. B.
TI Multiscale Simulations of Anisotropic Grain Growth Using Wavelet Based
Multiresolution Analysis
SO JOURNAL OF APPLIED MECHANICS-TRANSACTIONS OF THE ASME
LA English
DT Article
ID MONTE-CARLO-SIMULATION; NANOCRYSTALLINE MATERIALS; COMPUTER-SIMULATION;
EVOLUTION; COATINGS; SYSTEMS; FILMS
AB The present work serves to document the development and findings associated with a wavelet-based multiscale simulation analysis for anisotropic grain growth of a two-dimensional polycrystalline material. In particular, lattice-based Monte Carlo and atomically-based Molecular Dynamics simulations are used to compute the grain boundary energies over their respective spatial domains. Serial coupling is performed utilizing an orthonormal set of Haar wavelet transforms embedded within a corresponding multi-resolution analysis. For the Monte Carlo approach, anisotropies in grain boundary energies, caused by differences in grain orientation (texturing), are examined using two distinct methods, while the molecular dynamics simulations, offering inherent anisotropy, are conducted assuming the interatomic Lennard Jones potential. Among other findings, under the present context, the results confirm the viability of the wavelet-based multiresolution analysis (MRA) method for use as a potential coupling agent, and provide substantiation for its use with other applications. The results further offer quantitative comparisons between isotropic and anisotropic modeling results, and demonstrate their range of applicability.
C1 [Allen, J. B.] US Army Engineer Res & Dev Ctr, Informat Technol Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
RP Allen, JB (reprint author), US Army Engineer Res & Dev Ctr, Informat Technol Lab, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
EM Jeffrey.B.Allen@usace.army.mil
NR 36
TC 0
Z9 0
U1 3
U2 3
PU ASME
PI NEW YORK
PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA
SN 0021-8936
EI 1528-9036
J9 J APPL MECH-T ASME
JI J. Appl. Mech.-Trans. ASME
PD OCT
PY 2016
VL 83
IS 10
AR 101011
DI 10.1115/1.4034388
PG 7
WC Mechanics
SC Mechanics
GA DW8FA
UT WOS:000383888600011
ER
PT J
AU Wallace, SA
Meyer, RM
Cirivello, MJ
Cho, RI
AF Wallace, Scott A.
Meyer, R. Michael
Cirivello, Michael J.
Cho, Raymond I.
TI Lateral orbitotomy for a maxillary nerve schwannoma: case report
SO JOURNAL OF NEUROSURGERY
LA English
DT Article
DE trigeminal schwannoma; lateral orbitotomy; maxillary nerve; surgical
technique
ID OF-THE-LITERATURE; TRIGEMINAL-SCHWANNOMAS; SURGICAL-MANAGEMENT;
NEURINOMAS; EXPERIENCE; SERIES
AB Authors of this report describe a Fukushima Type D(b) or Kawase Type ME2 trigeminal schwannoma involving the right maxillary division in a 59-year-old woman who presented with intermittent right-sided facial numbness and pain. This tumor was successfully resected via a right lateral orbitotomy without the need for craniotomy. This novel approach to a lesion of this type has not yet been described in the scientific literature. The outcome in this case was good, and the patient's intra- and postoperative courses proceeded without complication. The epidemiology of trigeminal schwan-nomas and some technical aspects of lateral orbitotomy, including potential advantages of this approach over traditional transcranial as well as fully endoscopic dissections in appropriately selected cases, are also briefly discussed.
C1 [Wallace, Scott A.; Cirivello, Michael J.] Walter Reed Army Med Ctr, Dept Neurosurg, Bethesda, MD USA.
[Cho, Raymond I.] Walter Reed Army Med Ctr, Dept Ophthalmol, Bethesda, MD USA.
[Meyer, R. Michael] Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Bethesda, MD 20814 USA.
RP Meyer, RM (reprint author), 11727 Coll View Dr, North Kensington, MD 20902 USA.
EM raymond.meyer@usuhs.edu
NR 25
TC 0
Z9 0
U1 1
U2 1
PU AMER ASSOC NEUROLOGICAL SURGEONS
PI ROLLING MEADOWS
PA 5550 MEADOWBROOK DRIVE, ROLLING MEADOWS, IL 60008 USA
SN 0022-3085
EI 1933-0693
J9 J NEUROSURG
JI J. Neurosurg.
PD OCT
PY 2016
VL 125
IS 4
BP 869
EP 876
DI 10.3171/2015.7.JNS15422
PG 8
WC Clinical Neurology; Surgery
SC Neurosciences & Neurology; Surgery
GA DW8XM
UT WOS:000383938800011
PM 26745488
ER
PT J
AU Nezafati, M
Cho, K
Giri, A
Kim, CS
AF Nezafati, Marjan
Cho, Kyu
Giri, Anit
Kim, Chang-Soo
TI DFT study on the water molecule adsorption and the surface dissolution
behavior of Mg alloys
SO MATERIALS CHEMISTRY AND PHYSICS
LA English
DT Article
DE Alloys; Surfaces; Ab initio calculations; Adsorption; Corrosion
ID MAGNESIUM ALLOYS; CORROSION BEHAVIOR; CRYSTALLOGRAPHIC ORIENTATION;
MG-5AL ALLOY; AL ALLOYS; CA; PERFORMANCE; MORPHOLOGY; NITROGEN; CALCIUM
AB Mg-based alloys have a strong potential for various structural and biomedical applications. A critical issue associated with Mg-based alloys is their high degradation (corrosion) rates in oxidation environments. It is known that both the internal crystal structures and the impurity compositions/contents in the Mg alloys can affect the degradation rates. In the present work, we employed the density-functional theory (DFT) computation technique to understand the surface degradation behaviors with different crystallographic orientations and impurity elements from an atomistic point of view. Here, we studied the adsorption response of a water molecule to the Mg alloy surface and the dissolution of surface atoms that can be potentially applied to describe the degradation behavior of Mg/Mg alloy. The tendency for water molecule adsorption was quantified for Mg-based slab systems with low-index surface planes and various alloying elements including Al, Zn, Ca, and Y. The trends for surface degradation from these systems were examined using surface energy analysis and electrode potential shift analysis. The results show that adding Ca and/or Y increases the propensity to attract a water molecule to the alloy surface. Also, it was generally found that the relative electrode potential shift of Mg-Y alloys is positive while those of all other alloys are negative. (C) 2016 Elsevier B.V. All rights reserved.
C1 [Nezafati, Marjan; Kim, Chang-Soo] Univ Wisconsin Milwaukee, Mat Sci & Engn Dept, 3200 N Cramer St, Milwaukee, WI 53211 USA.
[Cho, Kyu; Giri, Anit] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA.
[Giri, Anit] TKC Global, Herndon, VA 20171 USA.
RP Kim, CS (reprint author), Univ Wisconsin Milwaukee, Mat Sci & Engn Dept, 3200 N Cramer St, Milwaukee, WI 53211 USA.
EM kimcs@uwm.edu
OI Nezafati, Marjan/0000-0002-6939-0460
FU U.S. Army Research Laboratory (U.S. ARL) [W911NF-15-2-0005]
FX This material is based upon work supported by the U.S. Army Research
Laboratory (U.S. ARL) under Cooperative Agreement No. W911NF-15-2-0005.
The views, opinions, and conclusions made in this document are those of
the authors and should not be interpreted as representing the official
policies, either expressed or implied, of Army Research Laboratory or
the U.S. Government. The U.S. Government is authorized to reproduce and
distribute reprints for Government purposes notwithstanding any
copyright notation herein.
NR 54
TC 0
Z9 0
U1 12
U2 12
PU ELSEVIER SCIENCE SA
PI LAUSANNE
PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND
SN 0254-0584
EI 1879-3312
J9 MATER CHEM PHYS
JI Mater. Chem. Phys.
PD OCT 1
PY 2016
VL 182
BP 347
EP 358
DI 10.1016/j.matchemphys2016.07.042
PG 12
WC Materials Science, Multidisciplinary
SC Materials Science
GA DW3EM
UT WOS:000383524900043
ER
PT J
AU Adorni, M
Herranz, LE
Hollands, T
Ahn, KI
Bals, C
D'Auria, F
Horvath, GL
Jaeckel, BS
Kim, HC
Lee, JJ
Ogino, M
Techy, Z
Velazquez-Lozad, A
Zigh, A
Rehacek, R
AF Adorni, Martina
Herranz, Luis E.
Hollands, Thorsten
Ahn, Kwang-Il
Bals, Christine
D'Auria, Francesco
Horvath, Gabor L.
Jaeckel, Bernd S.
Kim, Han-Chul
Lee, Jung-Jae
Ogino, Masao
Techy, Zsolt
Velazquez-Lozad, Alexander
Zigh, Abdelghani
Rehacek, Radomir
TI OECD/NEA Sandia Fuel Project phase I: Benchmark of the ignition testing
SO NUCLEAR ENGINEERING AND DESIGN
LA English
DT Article
AB The OECD/NEA Sandia Fuel Project provided unique thermal-hydraulic experimental data associated with Spent Fuel Pool (SFP) complete drain down. The study conducted at Sandia National Laboratories (SNL) was successfully completed (July 2009 to February 2013). The accident conditions of interest for the SFP were simulated in a full scale prototypic fashion (electrically heated, prototypic assemblies in a prototypic SFP rack) so that the experimental results closely represent actual fuel assembly responses. A major impetus for this work was to facilitate severe accident code validation and to reduce modeling uncertainties within the codes. Phase I focused on axial heating and burn propagation in a single PWR 17 x 17 assembly (i.e. "hot neighbors" configuration). Phase II addressed axial and radial heating and zirconium fire propagation including effects of fuel rod ballooning in a 1 x 4 assembly configuration (i.e. single, hot center assembly and four, "cooler neighbors").
This paper summarizes the comparative analysis regarding the final destructive ignition test of the phase I of the project. The objective of the benchmark is to evaluate and compare the predictive capabilities of computer codes concerning the ignition testing of PWR fuel assemblies. Nine institutions from eight different countries were involved in the benchmark calculations.
The time to ignition and the maximum temperature are adequately captured by the calculations. It is believed that the benchmark constitutes an enlargement of the validation range for the codes to the conditions tested, thus enhancing the code applicability to other fuel assembly designs and configurations. The comparison of lumped parameter and CFD computer codes represents a further valuable achievement. (C) 2016 Elsevier B.V. All rights reserved.
C1 [Adorni, Martina; D'Auria, Francesco] UNIPI, Pisa, Italy.
[Herranz, Luis E.] CIEMAT, Madrid, Spain.
[Hollands, Thorsten] GRS, Aachen, Germany.
[Ahn, Kwang-Il] KAERI, Daejeon, South Korea.
[Horvath, Gabor L.; Techy, Zsolt] NUBIKI, Budapest, Hungary.
[Jaeckel, Bernd S.] PSI, Villigen, Switzerland.
[Kim, Han-Chul; Lee, Jung-Jae] KINS, Daejeon, South Korea.
[Ogino, Masao] JNES, Tokyo, Japan.
[Velazquez-Lozad, Alexander; Zigh, Abdelghani] USNRC, USA, Chapel Hill, NC USA.
[Rehacek, Radomir] OECD NEA, Paris, France.
RP Adorni, M (reprint author), UNIPI, Pisa, Italy.
EM martina_adorni@hotmail.it
NR 21
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Z9 0
U1 8
U2 8
PU ELSEVIER SCIENCE SA
PI LAUSANNE
PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND
SN 0029-5493
EI 1872-759X
J9 NUCL ENG DES
JI Nucl. Eng. Des.
PD OCT
PY 2016
VL 307
BP 418
EP 430
DI 10.1016/j.nucengdes.2016.07.016
PG 13
WC Nuclear Science & Technology
SC Nuclear Science & Technology
GA DW7IM
UT WOS:000383824400035
ER
PT J
AU Watson, DC
Bayik, D
Srivatsan, A
Bergamaschi, C
Valentin, A
Niu, G
Bear, J
Monninger, M
Sun, M
Morales-Kastresana, A
Jones, JC
Felber, BK
Chen, XY
Gursel, I
Pavlakis, GN
AF Watson, Dionysios C.
Bayik, Defne
Srivatsan, Avinash
Bergamaschi, Cristina
Valentin, Antonio
Niu, Gang
Bear, Jenifer
Monninger, Mitchell
Sun, Mei
Morales-Kastresana, Aizea
Jones, Jennifer C.
Felber, Barbara K.
Chen, Xiaoyuan
Gursel, Ihsan
Pavlakis, George N.
TI Efficient production and enhanced tumor delivery of engineered
extracellular vesicles
SO BIOMATERIALS
LA English
DT Article
DE Exosomes; Drug delivery; Biodistribution; Scavenger receptor;
Reticuloendothelial system; Dextran sulfate
ID CELL-DERIVED EXOSOMES; SCAVENGER RECEPTOR; IN-VIVO; B16BL6-DERIVED
EXOSOMES; CLASS-A; IL-15; MICE; BIODISTRIBUTION; IL-15R-ALPHA; CANCER
AB Extracellular vesicles (EV), including exosomes and microvesicles, are nano-sized intercellular communication vehicles that participate in a multitude of physiological processes. Due to their biological properties, they are also promising candidates for the systemic delivery of therapeutic compounds, such as cytokines, chemotherapeutic drugs, siRNAs and viral vectors. However, low EV production yield and rapid clearance of administered EV by liver macrophages limit their potential use as therapeutic vehicles. We have used a hollow-fiber bioreactor for the efficient production of bioactive EV bearing the heterodimeric cytokine complex Interleukin-15:Interleukin-15 receptor alpha. Bioreactor culture yielded-40fold more EV per mL conditioned medium, as compared to conventional cell culture. Biophysical analysis and comparative proteomics suggested a more diverse population of EV in the bioreactor preparations, while serum protein contaminants were detectable only in conventional culture EV preparations. We also identified the Scavenger Receptor Class A family (SR-A) as a novel monocyte/macrophage uptake receptor for EV. In vivo blockade of SR-A with dextran sulfate dramatically decreased EV liver clearance in mice, while enhancing tumor accumulation. These findings facilitate development of EV therapeutic methods. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
C1 [Watson, Dionysios C.; Valentin, Antonio; Pavlakis, George N.] Natl Canc Inst Frederick, Ctr Canc Res, Vaccine Branch, Human Retrovirus Sect, Frederick, MD 21702 USA.
[Bayik, Defne] Natl Canc Inst Frederick, Ctr Canc Res, Canc & Inflammat Program, Frederick, MD 21702 USA.
[Bayik, Defne; Gursel, Ihsan] Bilkent Univ, Dept Mol Biol & Genet, TR-06800 Ankara, Turkey.
[Srivatsan, Avinash; Niu, Gang; Chen, Xiaoyuan] Natl Inst Biomed Imaging & Bioengn, Lab Mol Imaging & Nanomed, NIH, Bethesda, MD 20892 USA.
[Bergamaschi, Cristina; Bear, Jenifer; Felber, Barbara K.] Natl Canc Inst Frederick, Ctr Canc Res, Vaccine Branch, Human Retrovirus Pathogenesis Sect, Frederick, MD 21702 USA.
[Monninger, Mitchell; Sun, Mei] United States Army, Div Pathol, Med Res Inst Infect Dis, Frederick, MD 21702 USA.
[Morales-Kastresana, Aizea; Jones, Jennifer C.] NCI, Vaccine Branch, Ctr Canc Res, Bethesda, MD 20892 USA.
RP Pavlakis, GN (reprint author), Natl Canc Inst Frederick, Ctr Canc Res, Vaccine Branch, Human Retrovirus Sect, Frederick, MD 21702 USA.
EM George.pavlakis@nih.gov
RI Jones, Jennifer/C-8691-2015;
OI Jones, Jennifer/0000-0002-9488-7719; Watson,
Dionysios/0000-0002-9146-5641
FU Intramural Research Program of the National Institutes of Health,
National Cancer Institute, Center for Cancer Research; Admune/Novartis;
National Cancer Institute/NIH, USA
FX We thank William C. Kopp and Yanyt Wang for the IL-15 bioactivity
testing; Ming Zhou for mass spectrometry; John Cad well for discussions
and for providing Fibercell hollow-fiber materials; Joseph Meyer for
artwork; and Terry Jones for administrative support. Research supported
by the Intramural Research Program of the National Institutes of Health,
National Cancer Institute, Center for Cancer Research. Research also
supported by Admune/Novartis through a collaborative agreement with the
National Cancer Institute/NIH, USA. Opinions, interpretations,
conclusions, and recommendations are those of the authors and are not
necessarily endorsed by the U.S. Army.
NR 40
TC 4
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U1 48
U2 48
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0142-9612
EI 1878-5905
J9 BIOMATERIALS
JI Biomaterials
PD OCT
PY 2016
VL 105
BP 195
EP 205
DI 10.1016/j.biomaterials.2016.07.003
PG 11
WC Engineering, Biomedical; Materials Science, Biomaterials
SC Engineering; Materials Science
GA DV9ZD
UT WOS:000383299800018
PM 27522254
ER
PT J
AU Johnson, AE
AF Johnson, Anthony E.
TI CORR Insights(A (R)): Shoulder Activity Level is Associated with Type of
Employment and Income in the Normative Population Without Shoulder
Disorders
SO CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
LA English
DT Article
C1 [Johnson, Anthony E.] Brooke Army Med Ctr, Dept Orthopaed Surg, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
RP Johnson, AE (reprint author), Brooke Army Med Ctr, Dept Orthopaed Surg, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
EM anthony.e.johnson.mil@mail.mil
OI Johnson, Anthony/0000-0002-0506-0059
NR 11
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0009-921X
EI 1528-1132
J9 CLIN ORTHOP RELAT R
JI Clin. Orthop. Rel. Res.
PD OCT
PY 2016
VL 474
IS 10
BP 2277
EP 2279
DI 10.1007/s11999-016-5008-8
PG 3
WC Orthopedics; Surgery
SC Orthopedics; Surgery
GA DV4YC
UT WOS:000382930700036
PM 27484413
ER
PT J
AU Kube, CM
Arguelles, AP
AF Kube, Christopher M.
Arguelles, Andrea P.
TI Bounds and self-consistent estimates of the elastic constants of
polycrystals
SO COMPUTERS & GEOSCIENCES
LA English
DT Article
DE Elastic constants; Hashin-Shtrikman bounds; Self-consistent;
Voigt-Reuss-Hill average; Polycrystals; Wave velocity; Average
properties
ID HASHIN-SHTRIKMAN BOUNDS; TETRAGONAL SYMMETRIES; VARIATIONAL APPROACH;
SINGLE-CRYSTAL; MODULI; BEHAVIOUR
AB The Hashin-Shtrikman bounds on the elastic constants have been previously calculated for polycrystalline materials with crystallites having general elastic symmetry (triclinic crystallite symmetry). However, the calculation of tighter bounds and the self-consistent estimates of these elastic constants has remained unsolved. In this paper, a general theoretical expression for the self-consistent elastic constants is formulated. An iterative method is used to solve the expression for the self-consistent estimates. Each iteration of the solution gives the next tighter set of bounds including the well-known Voigt-Reuss and Hashin-Shtrikman bounds. Thus, all of the bounds on the elastic constants and the self consistent estimates for any crystallite symmetry are obtained in a single, computationally efficient procedure. The bounds and self-consistent elastic constants are reported for several geophysical materials having crystallites of monoclinic and triclinic symmetries. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Kube, Christopher M.] Army Res Lab, Vehicle Technol Directorate, Mech Div, 4603 Flare Loop, Aberdeen Proving Ground, MD 21005 USA.
[Arguelles, Andrea P.] Univ Nebraska, Dept Mech & Mat Engn, W342 Nebraska Hall, Lincoln, NE 68588 USA.
RP Kube, CM (reprint author), Army Res Lab, Vehicle Technol Directorate, Mech Div, 4603 Flare Loop, Aberdeen Proving Ground, MD 21005 USA.
EM christopher.m.kube.ctr@mail.mil; arguelles1@gmail.com
NR 27
TC 0
Z9 0
U1 7
U2 7
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0098-3004
EI 1873-7803
J9 COMPUT GEOSCI-UK
JI Comput. Geosci.
PD OCT
PY 2016
VL 95
BP 118
EP 122
DI 10.1016/j.cageo.2016.07.008
PG 5
WC Computer Science, Interdisciplinary Applications; Geosciences,
Multidisciplinary
SC Computer Science; Geology
GA DV5ZU
UT WOS:000383010000011
ER
PT J
AU D'Souza, K
Bayrak, AE
Kang, N
Wang, H
Altin, B
Barton, K
Hu, J
Papalambros, P
Epureanu, BI
Gerth, R
AF D'Souza, Kiran
Bayrak, Alparslan Emrah
Kang, Namwoo
Wang, Hui
Altin, Berk
Barton, Kira
Hu, Jack
Papalambros, Panos
Epureanu, Bogdan I.
Gerth, Richard
TI An integrated design approach for evaluating the effectiveness and cost
of a fleet
SO JOURNAL OF DEFENSE MODELING AND SIMULATION-APPLICATIONS METHODOLOGY
TECHNOLOGY-JDMS
LA English
DT Article
DE Modularity; fleet optimization; system design; fleet operation
simulation
ID FREIGHT TRANSPORTATION; SYSTEM; OPTIMIZATION; OWNERSHIP; VEHICLES
AB This work presents a new method for designing and evaluating different fleet paradigms to determine an effective and cost efficient solution. The method requires the user to define a set of functions which must be carried out by the fleet, as well as a set of candidate vehicles or systems that can carry out these functions. These function and fleet models are then evaluated to determine their performance. All the data is then fed into a stochastic dynamic fleet operation model to identify the amount of vehicles or systems needed to complete each mission defined on a fixed time horizon. The output of the fleet operation model is then used by cost models to determine the cost of completing each fleet mission. The overall approach is demonstrated on a military fleet composed of two different types of vehicle: a conventional fleet and a fleet composed of modules. The method shows the potential for savings using a modular fleet for a hypothetical fleet mission profile; more work in this area is suggested.
C1 [D'Souza, Kiran] Ohio State Univ, Mech & Aerosp Engn Dept, 2300 West Case Rd, Columbus, OH 43235 USA.
[Bayrak, Alparslan Emrah; Kang, Namwoo; Barton, Kira; Papalambros, Panos; Epureanu, Bogdan I.] Univ Michigan, Dept Mech Engn, Ann Arbor, MI 48109 USA.
[Altin, Berk] Univ Michigan, Ann Arbor, MI 48109 USA.
[Hu, Jack] Univ Michigan, Mech Engn & Ind & Operat Engn, Ann Arbor, MI 48109 USA.
[Papalambros, Panos] Univ Michigan, Dept Integrat Syst & Design, Ann Arbor, MI 48109 USA.
Florida State Univ, Tallahassee, FL 32306 USA.
[Gerth, Richard] US Army, TARDEC, Washington, DC 20310 USA.
RP D'Souza, K (reprint author), Ohio State Univ, Mech & Aerosp Engn Dept, 2300 West Case Rd, Columbus, OH 43235 USA.
EM dsouza.60@osu.edu
RI D'Souza, Kiran/J-6120-2014;
OI D'Souza, Kiran/0000-0002-1144-2432; Bayrak, Alparslan
Emrah/0000-0002-8524-2265
FU Automotive Research Center, a US Army Center of Excellence in Modeling
and Simulation of Ground Vehicle Systems, headquartered at the
University of Michigan in Ann Arbor; TARDEC, Warren, Michigan
FX The research was supported financially by the Automotive Research
Center, a US Army Center of Excellence in Modeling and Simulation of
Ground Vehicle Systems, headquartered at the University of Michigan in
Ann Arbor, in partnership with TARDEC, Warren, Michigan.
NR 35
TC 0
Z9 0
U1 0
U2 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1548-5129
EI 1557-380X
J9 J DEF MODEL SIMUL-AP
JI J. Def. Model. Simul.-Appl. Methodol. Technol.-JDMS
PD OCT
PY 2016
VL 13
IS 4
BP 381
EP 397
DI 10.1177/1548512916651939
PG 17
WC Engineering, Multidisciplinary
SC Engineering
GA DV5TK
UT WOS:000382992200002
ER
PT J
AU Haile, MA
Dykas, B
AF Haile, Mulugeta A.
Dykas, Brian
TI Blind source separation for vibration-based diagnostics of rotorcraft
bearings
SO JOURNAL OF VIBRATION AND CONTROL
LA English
DT Article
DE Bearing diagnostics; blind source separation; mixed signals; sensor and
source signals
ID INDEPENDENT COMPONENT ANALYSIS; FAULT-DIAGNOSIS; 2ND-ORDER STATISTICS;
SIGNAL SEPARATION; WAVELET TRANSFORM; IDENTIFICATION; DECOMPOSITION;
ALGORITHMS; MACHINERY
AB The vibration signals from sensors monitoring the activity of individual bearings in a power train unit may be linear instantaneous mixtures of vibrations generated by various dynamic components. Generally, an exact physical model describing the mixing process and the contribution of each dynamic component to the received sensor signal is not available. Vibration source signals from defective bearings often overlap in time and frequency, and, as such, the direct use of time- and frequency-domain methods may result in erroneous diagnostic information. This paper implements blind source separation (BSS) to demix sensor signals into correctly identifiable vibration source signals without the need of the vibration path property and sensor layout. Experimental vibration data from spalled, corroded, and healthy rotorcraft bearings are used with five representative BSS algorithms. The separation accuracy of these algorithms is then compared using various performance metrics. Results show that despite the inherent statistical dependence and near Gaussianity, it is possible to isolate vibration sources from mixed sensor signals using second- and higher-order statistics of the signals. The paper also identifies the limitations of the BSS technique and provides a remedy and recommendation for its implementation in rotorcraft bearing fault detection.
C1 [Haile, Mulugeta A.; Dykas, Brian] US Army Res Lab, Aberdeen Proving Ground, MD USA.
RP Haile, MA (reprint author), US Army Res Lab, Vehicle Technol Directorate, RDRL VTM, Bldg 4603,Room 216-04B, Aberdeen Proving Ground, MD 21005 USA.
EM mulugeta.a.haile@us.army.mil
NR 39
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Z9 1
U1 10
U2 10
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1077-5463
EI 1741-2986
J9 J VIB CONTROL
JI J. Vib. Control
PD OCT
PY 2016
VL 22
IS 18
BP 3807
EP 3820
DI 10.1177/1077546314566041
PG 14
WC Acoustics; Engineering, Mechanical; Mechanics
SC Acoustics; Engineering; Mechanics
GA DV9JI
UT WOS:000383256300002
ER
PT J
AU Cnops, L
van Griensven, J
Honko, AN
Bausch, DG
Sprecher, A
Hill, CE
Colebunders, R
Johnson, JC
Griffiths, A
Palacios, GF
Kraft, CS
Kobinger, G
Hewlett, A
Norwood, DA
Sabeti, P
Jahrling, PB
Formenty, P
Kuhn, JH
Arien, KK
AF Cnops, Lieselotte
van Griensven, Johan
Honko, Anna N.
Bausch, Daniel G.
Sprecher, Armand
Hill, Charles E.
Colebunders, Robert
Johnson, Joshua C.
Griffiths, Anthony
Palacios, Gustavo F.
Kraft, Colleen S.
Kobinger, Gary
Hewlett, Angela
Norwood, David A.
Sabeti, Pardis
Jahrling, Peter B.
Formenty, Pierre
Kuhn, Jens H.
Arien, Kevin K.
TI Overlooking the importance of immunoassays reply
SO LANCET INFECTIOUS DISEASES
LA English
DT Letter
C1 [Cnops, Lieselotte; van Griensven, Johan] Inst Trop Med, Dept Clin Sci, Antwerp, Belgium.
[Honko, Anna N.; Johnson, Joshua C.; Jahrling, Peter B.; Kuhn, Jens H.] NIAID, Integrated Res Facil Ft Detrick, Div Clin Res, NIH, Frederick, MD USA.
[Bausch, Daniel G.; Formenty, Pierre] WHO, Geneva, Switzerland.
[Sprecher, Armand] Med Sans Frontieres Operat Ctr Brussels, Brussels, Belgium.
[Hill, Charles E.] Emory Univ Hosp, Mol Diagnost Lab, 1364 Clifton Rd NE, Atlanta, GA 30322 USA.
[Colebunders, Robert] Univ Antwerp, Int Hlth Unit, Global Hlth Inst, Fac Med & Hlth Sci, Antwerp, Belgium.
[Griffiths, Anthony] Texas Biomed Res Inst, Dept Virol & Immunol, San Antonio, TX USA.
[Palacios, Gustavo F.; Norwood, David A.] US Army, Med Res Inst Infect Dis, Frederick, MD USA.
[Kraft, Colleen S.] Emory Univ, Sch Med, Pathol & Lab Med, Atlanta, GA USA.
[Kobinger, Gary] Univ Manitoba, Natl Microbiol Lab, Publ Hlth Agcy Canada, Winnipeg, MB, Canada.
[Hewlett, Angela] Univ Nebraska Med Ctr, Omaha, NE USA.
[Sabeti, Pardis] Harvard Univ, Dept Organism & Evolutionary Biol, FAS Ctr Syst Biol, Cambridge, MA 02138 USA.
[Arien, Kevin K.] Inst Trop Med, Dept Biomed Sci, Antwerp, Belgium.
RP Arien, KK (reprint author), Inst Trop Med, Dept Biomed Sci, Antwerp, Belgium.
EM karien@itg.be
NR 5
TC 0
Z9 0
U1 2
U2 2
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1473-3099
EI 1474-4457
J9 LANCET INFECT DIS
JI Lancet Infect. Dis.
PD OCT
PY 2016
VL 16
IS 10
BP 1110
EP 1110
PG 1
WC Infectious Diseases
SC Infectious Diseases
GA DW2JP
UT WOS:000383469000024
PM 27676345
ER
PT J
AU Corona, BT
Greising, SM
AF Corona, Benjamin T.
Greising, Sarah M.
TI Challenges to acellular biological scaffold mediated skeletal muscle
tissue regeneration
SO BIOMATERIALS
LA English
DT Review
DE Extracellular matrix; Musculoskeletal healing; Muscle fibrosis;
Neuromuscular strength; Orthopaedic trauma; Regenerative medicine;
Satellite cell; Skeletal muscle injury; Volumetric muscle loss
ID CONTRACTION-INDUCED INJURY; SATELLITE CELLS; EXTRACELLULAR-MATRIX;
IN-VIVO; FUNCTIONAL RECOVERY; MURINE MODEL; ECCENTRIC CONTRACTIONS;
MACROPHAGE PHENOTYPE; BASEMENT-MEMBRANE; EXTREMITY TRAUMA
AB Volumetric muscle loss (VML) injuries present a complex and heterogeneous clinical problem that results in a chronic loss of muscle tissue and strength. The primary limitation to muscle tissue regeneration after VML injury is the frank loss of all native muscle constituents in the defect, especially satellite cells and the basal lamina. Recent advancements in regenerative medicine have set forth encouraging and emerging translational and therapeutic options for these devastating injuries including the surgical implantation of acellular biological scaffolds. While these biomaterials can modulate the wound environment, the existing data do not support their capacity to promote appreciable muscle fiber regeneration that can contribute to skeletal muscle tissue functional improvements. An apparent restriction of endogenous satellite cell (i.e., pax7(+)) migration to acellular biological scaffolds likely underlies this deficiency. This work critically evaluates the role of an acellular biological scaffold in orchestrating skeletal muscle tissue regeneration, specifically when used as a regenerative medicine approach for VML injury. Published by Elsevier Ltd.
C1 [Corona, Benjamin T.; Greising, Sarah M.] US Army, Inst Surg Res, Extrem Trauma & Regenerat Med Task Area, 3698 Chambers Pass,BHT1, Ft Sam Houston, TX 78234 USA.
RP Corona, BT (reprint author), US Army, Inst Surg Res, Extrem Trauma & Regenerat Med Task Area, 3698 Chambers Pass,BHT1, Ft Sam Houston, TX 78234 USA.
EM benjamin.t.corona.civ@mail.mil
FU United States Army Military Research and Materiel Command
FX This work was supported by the United States Army Military Research and
Materiel Command through their Combat Casualty Care and Clinical &
Rehabilitative Medicine Research Programs.
NR 91
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U1 28
U2 29
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0142-9612
EI 1878-5905
J9 BIOMATERIALS
JI Biomaterials
PD OCT
PY 2016
VL 104
BP 238
EP 246
DI 10.1016/j.biomaterials.2016.07.020
PG 9
WC Engineering, Biomedical; Materials Science, Biomaterials
SC Engineering; Materials Science
GA DU6SN
UT WOS:000382345000021
PM 27472161
ER
PT J
AU Gomes, ER
Mulligan, RP
Brodie, KL
McNinch, JE
AF Gomes, Esther R.
Mulligan, Ryan P.
Brodie, Katherine L.
McNinch, Jesse E.
TI Bathymetric control on the spatial distribution of wave breaking in the
surf zone of a natural beach
SO COASTAL ENGINEERING
LA English
DT Article
DE Surface wave transformation; Wave breaking; Energy dissipation;
Nearshore processes; Coastal morphology; SWASH model; Non-hydrostatic
modelling; LIDAR observations
ID LONGSHORE CURRENTS; SWASH ZONE; NEARSHORE; LIDAR; TRANSFORMATION;
EQUATIONS; PRESSURE; DYNAMICS; RUNUP; MODEL
AB A non-hydrostatic wave model (SWASH) that phase-resolves the free surface and fluid motions in the water column is applied to investigate wave transformation and the spatial distribution of wave breaking over different morphological:features. The model is forced using observed directional energy spectra and results are compared to wave observations collected outside the surf zone using acoustic wave sensors, and over a 100 m nearshore transect using high-frequency measurements of the sea surface from a LIDAR sensor mounted on the beach dune at the Field Research Facility in Duck, NC. The model is applied to four cases with different wave conditions and bathymetry, tested for sensitivity of model parameters to these different natural conditions, and used to predict the spatial variability in wave breaking and correlation between energy dissipation and morphologic features. Model results compare very well with observations of spectral evolution outside the surf zone, and generally well with the remotely sensed observations of wave transformation inside the surf zone with R = 0.85-0.93 for H-s along the cross-shore transect In particular the model is able to spatially resolve wave shoaling and dissipation at the shore break at the same location as observed in the LIDAR data. The results indicate that nearshore morphology has a significant effect on the spatial distribution of wave energy dissipation. Alongshore variability in bathymetry due to bars, rip channels, and larger morphological features such as the scour depression under the pier, causes large alongshore changes in cross-shore wave energy flux that influence the location and intensity of wave breaking. (C) 2016 Elsevier B.V. All rights reserved.
C1 [Gomes, Esther R.; Mulligan, Ryan P.] Queens Univ, Dept Civil Engn, Kingston, ON, Canada.
[Brodie, Katherine L.; McNinch, Jesse E.] US Army Engineer Res & Dev Ctr, Coastal & Hydraul Lab, Duck, NC USA.
RP Mulligan, RP (reprint author), Queens Univ, Dept Civil Engn, Kingston, ON, Canada.
EM mulligar@queensu.ca
FU Natural Sciences and Engineering Council of Canada (NSERC) Discovery
Grant
FX The data used in this study was provided by the US Army Corps of
Engineers (USACE), the US Army Research Office, the US Geological Survey
(USGS) and the USGS North Carolina Cooperative Research Project. We
thank Meg Palmsten of NRL for providing Argus imagery. The research was
supported by a Natural Sciences and Engineering Council of Canada
(NSERC) Discovery Grant to the second author.
NR 36
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Z9 0
U1 6
U2 6
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-3839
EI 1872-7379
J9 COAST ENG
JI Coast. Eng.
PD OCT
PY 2016
VL 116
BP 180
EP 194
DI 10.1016/j.coastaleng.2016.06.012
PG 15
WC Engineering, Civil; Engineering, Ocean
SC Engineering
GA DV0GZ
UT WOS:000382597300014
ER
PT J
AU Li-Byarlay, H
Huang, MH
Simone-Finstrom, M
Strand, MK
Tarpy, DR
Rueppell, O
AF Li-Byarlay, Hongmei
Huang, Ming Hua
Simone-Finstrom, Michael
Strand, Micheline K.
Tarpy, David R.
Rueppell, Olav
TI Honey bee (Apis mellifera) drones survive oxidative stress due to
increased tolerance instead of avoidance or repair of oxidative damage
SO EXPERIMENTAL GERONTOLOGY
LA English
DT Article
ID FREE-RADICAL THEORY; LIFE-SPAN; DROSOPHILA-MELANOGASTER;
GENE-EXPRESSION; PROTEIN OXIDATION; LONGEVITY; PARAQUAT; TOXICITY;
VITELLOGENIN; RESISTANCE
AB Oxidative stress can lead to premature aging symptoms and cause acute mortality at higher doses in a range of organisms. Oxidative stress resistance and longevity are mechanistically and phenotypically linked; considerable variation in oxidative stress resistance exists among and within species and typically covaries with life expectancy. However, it is unclear whether stress-resistant, long-lived individuals avoid, repair, or tolerate molecular damage to survive longer than others. The honey bee (Apis mellifera L.) is an emerging model system that is well-suited to address this question. Furthermore, this species is the most economically important pollinator, whose health may be compromised by pesticide exposure, including oxidative stressors. Here, we develop a protocol for inducing oxidative stress in honey beemales (drones) via Paraquat injection. After injection, individuals from different colony sources were kept in common social conditions to monitor their survival compared to saline-injected controls. Oxidative stress was measured in susceptible and resistant individuals. Paraquat drastically reduced survival but individuals varied in their resistance to treatment within and among colony sources. Longer-lived individuals exhibited higher levels of lipid peroxidation than individuals dying early. In contrast, the level of protein carbonylation was not significantly different between the two groups. This first study of oxidative stress in male honey bees suggests that survival of an acute oxidative stressor is due to tolerance, not prevention or repair, of oxidative damage to lipids. It also demonstrates colony differences in oxidative stress resistance that might be useful for breeding stress-resistant honey bees. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Li-Byarlay, Hongmei; Simone-Finstrom, Michael; Tarpy, David R.] North Carolina State Univ, Dept Entomol, Raleigh, NC 27695 USA.
[Li-Byarlay, Hongmei; Tarpy, David R.] North Carolina State Univ, WM Keck Ctr Behav Biol, Raleigh, NC USA.
[Li-Byarlay, Hongmei; Rueppell, Olav] Univ N Carolina, Dept Biol, Greensboro, NC USA.
[Huang, Ming Hua] Eurofins Agrosci Serv, Prospect Hill, NC USA.
[Strand, Micheline K.] US Army Res Off, Div Life Sci, Res Triangle Pk, NC USA.
[Simone-Finstrom, Michael] USDA ARS, Honey Bee Breeding Genet & Physiol Lab, 1157 Ben Hur Rd, Baton Rouge, LA 70820 USA.
RP Li-Byarlay, H (reprint author), North Carolina State Univ, Dept Entomol, Raleigh, NC 27695 USA.; Rueppell, O (reprint author), Univ N Carolina, Dept Biol, Greensboro, NC USA.
EM hlibyar@ncsu.edu; olav_rueppell@uncg.edu
OI Li-Byarlay, Hongmei/0000-0001-6579-5172; Rueppell,
Olav/0000-0001-5370-4229
FU National Research Council Research Associateship; National Institutes of
Aging [R21AG046837]; U.S. Army Research Laboratory [W911NF-04-D0003]
FX We are grateful to Jennifer Keller (North Carolina State University) for
her assistance on bee colonies, Ravi Dixit, Cheynne Lashmit, and Dr.
Marce Lorenzen (North Carolina State University) for their assistance on
assays, Prof. Coby Shal and Dr. Ayako Wada-Katsumata (North Carolina
State University) for their help on the microplate reader, and two
reviewers for their helpful suggestions. H.L.-B. was supported by the
National Research Council Research Associateship, and O.R. received
financial support from the National Institutes of Aging (Grant
#R21AG046837). This work was also supported by the U.S. Army Research
Laboratory (Grant: W911NF-04-D0003).
NR 65
TC 1
Z9 1
U1 29
U2 29
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0531-5565
EI 1873-6815
J9 EXP GERONTOL
JI Exp. Gerontol.
PD OCT
PY 2016
VL 83
BP 15
EP 21
DI 10.1016/j.exger.2016.07.003
PG 7
WC Geriatrics & Gerontology
SC Geriatrics & Gerontology
GA DU4XG
UT WOS:000382215600003
PM 27422326
ER
PT J
AU Gazonas, GA
Velo, AP
Wildman, RA
AF Gazonas, G. A.
Velo, A. P.
Wildman, R. A.
TI Asymptotic impact behavior of Goupillaud-type layered elastic media
SO INTERNATIONAL JOURNAL OF SOLIDS AND STRUCTURES
LA English
DT Article
DE Elastic wave propagation; Linear difference equations; Asymptotic
analysis; Recurrence relations; Impact boundary condition; Verification
of numerical codes
ID ANISOTROPIC MEDIA; WAVES; EXISTENCE
AB In this paper, we use the method of Riemann invariants to develop a system of recurrence relations for the one-dimensional elastic impact problem in which a semi-infinite flyer collides with (and adheres to) a stationary Goupillaud-type layered elastic target plate of finite thickness that is bonded to a semi infinite half-space. We derive explicit expressions for the long-time asymptotes of stress and particle velocity that are independent of the layered target's elastic properties. This result is verified by numerical simulations of impact into layered targets with periodic or randomly distributed elastic properties, and holds when the half-space backing the target is replaced by either free or fixed boundary conditions. Our discrete recurrence relation solutions for impact into layered media, generalize our recent analytical results concerning impact into homogeneous, single-layer targets, as well as prior discrete recurrence relation solutions for stress wave propagation in Goupillaud-type layered elastic media. Published by Elsevier Ltd.
C1 [Gazonas, G. A.; Wildman, R. A.] US Army, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA.
[Velo, A. P.] Univ San Diego, Dept Math & Comp Sci, 5998 Alcala Pk, San Diego, CA 92110 USA.
RP Gazonas, GA (reprint author), US Army, Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA.
EM george.a.gazonas.civ@mail.mil
FU Scientific Services Program (SSP) [W911NF-11-D-0001]
FX This research effort was partially sponsored by the Scientific Services
Program (SSP), administered by the Battelle Memorial Institute in North
Carolina for the U.S. Army Research Laboratory under contract No.
W911NF-11-D-0001. The authors would like to thank Dr. Michael Scheidler
at the U.S. Army Research Laboratory, Aberdeen Proving Ground, Maryland,
for his valuable insight on the impact boundary condition used in this
paper.
NR 19
TC 0
Z9 0
U1 2
U2 2
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0020-7683
EI 1879-2146
J9 INT J SOLIDS STRUCT
JI Int. J. Solids Struct.
PD OCT 1
PY 2016
VL 96
BP 38
EP 47
DI 10.1016/j.ijsolstr.2016.06.024
PG 10
WC Mechanics
SC Mechanics
GA DT2QE
UT WOS:000381324700004
ER
PT J
AU Zardaryan, E
Paronyan, L
Bakunts, V
Gevorgyan, Z
Asoyan, V
Apresyan, H
Hovhannisyan, A
Palayan, K
Kuchuloria, T
Rivard, RG
Bautista, CT
AF Zardaryan, Eduard
Paronyan, Lusine
Bakunts, Vahe
Gevorgyan, Zaruhi
Asoyan, Vigen
Apresyan, Hripsime
Hovhannisyan, Alvard
Palayan, Karo
Kuchuloria, Tinatin
Rivard, Robert G.
Bautista, Christian T.
TI Intestinal Infections Among Febrile Hospitalized Patients in the
Republic of Armenia: A Retrospective Chart Review
SO JOURNAL OF COMMUNITY HEALTH
LA English
DT Review
DE Enteric; Etiology; Epidemiology; Surveillance; Armenia
ID BACTERIAL ENTERIC INFECTIONS; UNITED-STATES; PATHOGENS; LENGTH; STAY
AB In the past, several enteric outbreaks in 1996, 1998, 1999, and 2003 caused by Salmonella typhi, a Gram-negative bacterium, have occurred in Armenia. This study describes the demographic, epidemiological, and clinical characteristics of febrile hospitalized patients with intestinal infections in Armenia. Using a chart review study design, medical data from adult patients who were hospitalized at the Nork hospital during 2010-2012 were reviewed. A total of 600 medical charts were reviewed. Of these, 51 % were diagnosed with intestinal infections. Among these patients, 59 % had an intestinal infection of known etiology, with three main pathogens identified: Salmonella sp. (32 %), Shigella sp. (32 %), and Staphylococcus aureus (18 %). After controlling for the calendar year, age in years, and gender, patients detected with Salmonella sp. were more likely to reported the presence of a family member with similar signs or symptoms [odds ratio (OR) 9.0; 95 % CI 2.4-33.7] and the lack of a water tap at home (OR 3.9; 95 % CI 1.7-9.5). Evidence indicates that Salmonella sp., Shigella sp., and S. aureus as the most common etiologies reported among febrile hospitalized patients. A high percentage of patients had intestinal infections of unknown etiology; thus, improvement in laboratory capacity (enabling more advanced tests, such as polymerase chain reaction) would increase the identification of the enteropathogens causing disease in Armenia.
C1 [Zardaryan, Eduard; Gevorgyan, Zaruhi; Asoyan, Vigen; Apresyan, Hripsime; Hovhannisyan, Alvard] Nork Infect Clin Hosp, Yerevan, Armenia.
[Paronyan, Lusine; Bakunts, Vahe; Palayan, Karo] Natl Ctr Dis Control & Prevent, Yerevan, Armenia.
[Kuchuloria, Tinatin; Rivard, Robert G.] US Army Med Res Inst Infect Dis, Ft Detrick, MD USA.
[Bautista, Christian T.] Walter Reed Army Inst Res, Silver Spring, MD USA.
RP Zardaryan, E (reprint author), Nork Infect Clin Hosp, Yerevan, Armenia.
EM Zardaryan@doctor.com; cbautistat@gmail.com
FU Defense Threat Reduction Agency through the Cooperative Biological
Engagement Program [CBEP-Armenia-TAP1]
FX This study was funded by the Defense Threat Reduction Agency through the
Cooperative Biological Engagement Program (CBEP-Armenia-TAP1).
NR 23
TC 0
Z9 0
U1 3
U2 3
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0094-5145
EI 1573-3610
J9 J COMMUN HEALTH
JI J. Community Health
PD OCT
PY 2016
VL 41
IS 5
BP 939
EP 945
DI 10.1007/s10900-016-0174-x
PG 7
WC Health Policy & Services; Public, Environmental & Occupational Health
SC Health Care Sciences & Services; Public, Environmental & Occupational
Health
GA DV1LH
UT WOS:000382682100006
PM 26992893
ER
PT J
AU Corron, NJ
Cooper, RM
Blakely, JN
AF Corron, Ned J.
Cooper, Roy M.
Blakely, Jonathan N.
TI Entropy rates of low-significance bits sampled from chaotic physical
systems
SO PHYSICA D-NONLINEAR PHENOMENA
LA English
DT Article
DE Chaos; Entropy; Symbolic dynamics; Partition
ID SEMICONDUCTOR-LASERS; GENERATION; DYNAMICS; NOISE; TIME; GB/S
AB We examine the entropy of low-significance bits in analog-to-digital measurements of chaotic dynamical systems. We find the partition of measurement space corresponding to low-significance bits has a corrugated structure. Using simulated measurements of a map and experimental data from a circuit, we identify two consequences of this corrugated partition. First, entropy rates for sequences of low significance bits more closely approach the metric entropy of the chaotic system, because the corrugated partition better approximates a generating partition. Second, accurate estimation of the entropy rate using low-significance bits requires long block lengths as the corrugated partition introduces more long-term correlation, and using only short block lengths overestimates the entropy rate. This second phenomenon may explain recent reports of experimental systems producing binary sequences that pass statistical tests of randomness at rates that may be significantly beyond the metric entropy rate of the physical source. Published by Elsevier B.V.
C1 [Corron, Ned J.; Cooper, Roy M.; Blakely, Jonathan N.] US Army Res Dev & Engn Command, Charles M Bowden Lab, Redstone Arsenal, AL 35898 USA.
RP Corron, NJ (reprint author), US Army RDECOM, RDMR WDS WO, Redstone Arsenal, AL 35898 USA.
EM ned.j.corron.civ@mail.mil
OI Corron, Ned/0000-0002-3232-5024
NR 28
TC 1
Z9 1
U1 4
U2 4
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0167-2789
EI 1872-8022
J9 PHYSICA D
JI Physica D
PD OCT 1
PY 2016
VL 332
BP 34
EP 40
DI 10.1016/j.physd.2016.06.003
PG 7
WC Mathematics, Applied; Physics, Multidisciplinary; Physics, Mathematical
SC Mathematics; Physics
GA DT5OF
UT WOS:000381531800004
ER
PT J
AU Subhash, G
Awasthi, AP
Kunka, C
Jannotti, P
DeVries, M
AF Subhash, Ghatu
Awasthi, Amnaya P.
Kunka, Cody
Jannotti, Phillip
DeVries, Matthew
TI In search of amorphization-resistant boron carbide
SO SCRIPTA MATERIALIA
LA English
DT Article
DE Boron carbide; Polymorph; Amorphization resistance; Raman spectra;
Cage-space; DFT
ID ELECTRONIC-STRUCTURE; IMPROVED DUCTILITY; B4C; SILICON; INDENTATION;
CERAMICS; SUBOXIDE; CHAINS
AB Despite its superior mechanical properties, boron carbide suffers from amorphization, a pressure-induced phenomenon that disturbs crystalline order and likely reduces shear strength. Numerous experimental and computational studies have investigated the structure and origins of amorphization, yet strategies to mitigate this deleterious phenomenon elude. However, recent investigations have revealed three new research avenues for addressing this issue. First, we identify crystallographic cage spaces that may accommodate foreign atoms to potentially prevent structural collapse. Second, we propose polymorph-level tailoring through strict control of processing conditions. Finally, we demonstrate that reducing grain size to nanometer scale increases hardness and may counter amorphization. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Subhash, Ghatu; Awasthi, Amnaya P.; Kunka, Cody; DeVries, Matthew] Univ Florida, Mech & Aerosp Engn, Gainesville, FL 32611 USA.
[Jannotti, Phillip] US Army, Res Labs, Aberdeen, MD 21005 USA.
RP Subhash, G (reprint author), POB 116250, Gainesville, FL 32611 USA.
EM subhash@ufl.edu; amnaya@ufl.edu; ckunka@ufl.edu;
phillip.a.jannotti.ctr@mail.mil; mdevries1120@ufl.edu
FU Army Research Office [ARO-W911NF-14-1-0230]; National Science Foundation
Graduate Research Fellowship [DGE-1315138]; [TG-MSS15006]
FX This material is based upon work supported by the Army Research Office
under Grant No. ARO-W911NF-14-1-0230 and by the National Science
Foundation Graduate Research Fellowship under Grant No. DGE-1315138.
This work used the Extreme Science and Engineering Discovery Environment
(XSEDE) using startup resources under project allocation TG-MSS15006.
Results presented in Figs. 2 and 3 have been obtained through the use of
the ABINIT code [47,48], a common project of the Universite Catholique
de Louvain, Corning Incorporated, the Universite de Liege, the
Commissariat a l'Energie Atomique, Mitsubishi Chemical Corp., the Ecole
Polytechnique Palaiseau, and other contributors (http://www.abinit.org).
We thank Nicholas Rudawski at University of Florida for his assistance
in transmission electron microscopy.
NR 47
TC 2
Z9 2
U1 10
U2 10
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 1359-6462
J9 SCRIPTA MATER
JI Scr. Mater.
PD OCT
PY 2016
VL 123
BP 158
EP 162
DI 10.1016/j.scriptamat.2016.06.012
PG 5
WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary;
Metallurgy & Metallurgical Engineering
SC Science & Technology - Other Topics; Materials Science; Metallurgy &
Metallurgical Engineering
GA DT5QS
UT WOS:000381538300037
ER
PT J
AU Jaim, HMI
Isaacs, RA
Rashkeev, SN
Kuklja, M
Cole, DP
LeMieux, MC
Jasiuk, I
Nilufar, S
Salamanca-Riba, LG
AF Jaim, H. M. Iftekhar
Isaacs, Romaine A.
Rashkeev, Sergey N.
Kuklja, Maija
Cole, Daniel P.
LeMieux, Melburne C.
Jasiuk, Iwona
Nilufar, Sabrina
Salamanca-Riba, Lourdes G.
TI Sp(2) carbon embedded in Al-6061 and Al-7075 alloys in the form of
crystalline graphene nanoribbons
SO CARBON
LA English
DT Article
ID REINFORCED ALUMINUM COMPOSITE; TOTAL-ENERGY CALCULATIONS;
RAMAN-SPECTROSCOPY; MOLECULAR-DYNAMICS; NANOTUBES; AL; SILVER
AB Electrocharging assisted process has been used to incorporate carbon in Aluminum 6061 and 7075 alloys ensuing significant improvements of the ultimate tensile strength, hardness, and electrical conductivity. This work investigates the presence of carbon, its structure, carbon-metal bonding, surface characterization and dispersion of carbon incorporated in Al alloys by electrocharging assisted process. Networks of Graphene nanoribbons with 3D epitaxy and preferred orientation along the < 110 > and < 112 > directions of Al are evident by transmission electron microscopy and spectrum imaging of the C-K edge electron energy loss spectra. X-ray photoelectron spectroscopy and Raman scattering corroborate sp(2) carbon in Al-6061, and hybrid sp(2)-sp(3) in Al-7075 with added carbon. Kelvin probe force microscopy substantiates the presence of carbon in the Al matrix. Phonon density of states derived from first-principles calculations predicts C-Al Raman active modes whilst density functional theory indicates covalent bonding between carbon and Al. This method of incorporation of graphene nanostructures in metals with strong carbon-metal bonding can open up new avenues for incorporation of sp(2) carbon structures in other materials. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Jaim, H. M. Iftekhar; Isaacs, Romaine A.; Rashkeev, Sergey N.; Kuklja, Maija; LeMieux, Melburne C.; Salamanca-Riba, Lourdes G.] Univ Maryland, Dept Mat Sci & Engn, College Pk, MD 20742 USA.
[Rashkeev, Sergey N.] Qatar Fdn, Qatar Environm & Energy Res Inst, POB 5825, Doha, Qatar.
[Cole, Daniel P.] US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
[Jasiuk, Iwona; Nilufar, Sabrina] Univ Illinois, Dept Mech Sci & Engn, Urbana, IL 61801 USA.
RP Salamanca-Riba, LG (reprint author), Univ Maryland, Dept Mat Sci & Engn, College Pk, MD 20742 USA.
EM riba@umd.edu
RI Isaacs, Romaine/A-3453-2016
OI Isaacs, Romaine/0000-0003-2401-7475
FU ONR [N000141410042]; DARPA/ARL [W911NF13100]; U.S. Army Research
Laboratory [W911QX-13-D-0003]; National Science Foundation; CMMI Program
[12-34130]
FX The Al-covetic samples were provided by Third Millennium Materials, LLC.
This work was supported in part by ONR under contract N000141410042 and
DARPA/ARL under contract W911NF13100. DPC is a contractor to the U.S.
Army Research Laboratory under contract W911QX-13-D-0003. IJ gratefully
acknowledges support from the National Science Foundation, the CMMI
Program Grant 12-34130. The authors are thankful to Dr. Karen Gaskell at
the Surface Analysis Center, UMD for her thoughtful discussions
regarding XPS data. We acknowledge the use of the TEM at the University
of Maryland Nanocenter and its AIM Laboratory.
NR 47
TC 2
Z9 2
U1 65
U2 75
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0008-6223
EI 1873-3891
J9 CARBON
JI Carbon
PD OCT
PY 2016
VL 107
BP 56
EP 66
DI 10.1016/j.carbon.2016.05.053
PG 11
WC Chemistry, Physical; Materials Science, Multidisciplinary
SC Chemistry; Materials Science
GA DS5EJ
UT WOS:000380803600006
ER
PT J
AU Dwivedi, AK
Dalzell, MW
Fossey, SA
Slusarski, KA
Long, LR
Wetzel, ED
AF Dwivedi, Ajmer K.
Dalzell, Michael W.
Fossey, Stephen A.
Slusarski, Kyle A.
Long, Larry R.
Wetzel, Eric D.
TI Low velocity ballistic behavior of continuous filament knit aramid
SO INTERNATIONAL JOURNAL OF IMPACT ENGINEERING
LA English
DT Article
DE Ballistic; Armor; Knit; Textile; Aramid
ID MECHANICAL-BEHAVIOR; FABRICS; YARNS; PLAIN
AB The ballistic perforation response of knits formed from continuous filament aramid is reported and compared to conventional armor textiles and commodity fabrics. The ballistic experiments consist of 6.0 mm-diameter glass spheres impacted into gelatin-backed targets with areal densities from 200 to 1000 g/m(2). These ballistic experiments are complemented with quasistatic reverse-perforation experiments to gain insights into deformation and failure for these materials. In-plane stretch experiments are also performed to quantify modulus and strain-to-failure. The results show that, while the ballistic performance of traditional woven textiles is generally superior to knitted aramids, knits formed from continuous filament aramid are significantly better than knits formed from staple yarn. Knitted structures are limited by two main factors: failure of a single yarn tends to lead to catastrophic deconstruction and perforation, and the low in-plane modulus of knits leads to poor lateral stress transfer and energy distribution during higher speed impact. Importantly, however, knits provide significantly more reversible elongation with less elastic resistance compared to other structures, such as woven textiles, making them well suited for wearable protection in which comfort is critical. The results also show that continuous filament knits can be produced with commercial manufacturing equipment, and that barriers composed of few layers of high-denier yarn knits likely provide more efficient ballistic resistance than equivalent weight barriers composed of many layers of low-denier yarn knits. Published by Elsevier Ltd.
C1 [Dwivedi, Ajmer K.; Slusarski, Kyle A.; Long, Larry R.; Wetzel, Eric D.] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA.
[Dalzell, Michael W.] Def Sci & Technol Lab, Salisbury SP4 0JQ, Wilts, England.
[Fossey, Stephen A.] US Natick Soldier Res Design & Engn Ctr, Natick, MA 01760 USA.
RP Wetzel, ED (reprint author), US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA.
EM eric.d.wetzel2.civ@mail.mil
NR 22
TC 0
Z9 0
U1 4
U2 4
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0734-743X
EI 1879-3509
J9 INT J IMPACT ENG
JI Int. J. Impact Eng.
PD OCT
PY 2016
VL 96
BP 23
EP 34
DI 10.1016/j.ijimpeng.2016.05.009
PG 12
WC Engineering, Mechanical; Mechanics
SC Engineering; Mechanics
GA DS1WD
UT WOS:000380414600003
ER
PT J
AU Leger, AS
Cecchi, V
Basu, M
Miu, K
Nwankpa, C
AF Leger, Aaron St.
Cecchi, Valentina
Basu, Megha
Miu, Karen
Nwankpa, Chika
TI Automated system for determining frequency dependent parameter model of
transmission line in a laboratory environment
SO MEASUREMENT
LA English
DT Article
DE Impedance measurement; Uncertainty; Digital signal processing; RMS
measurement; Frequency dependence; Experimental analysis
ID UNCERTAINTY; IMPEDANCE
AB This work presents an automated system for determining transmission line model parameters at various frequencies. The system was developed and implemented on General Electric test reactors designed to model power transmission line behavior in a laboratory environment. The measurement system and data processing are controlled and automated via custom developed LabVIEW software. Measurements are obtained from voltage and current probes interfacing with oscilloscopes. This data is then acquired and processed in LabVIEW software. The structure of the transmission line model, desired confidence level and number of tests to conduct are specified user inputs. The system subsequently provides the transmission line impedance parameters based on these specifications. These parameters are calculated using both time domain and frequency domain techniques. While this work focuses on determining transmission line model parameters, this automated test measurement system is applicable to any device that can be parameterized via a current-voltage (I-V) characteristic or frequency response. (C) Published by Elsevier Ltd.
C1 [Leger, Aaron St.] US Mil Acad, Dept Elect Engn & Comp Sci, West Point, NY 10996 USA.
[Cecchi, Valentina] Univ N Carolina, Dept Elect & Comp Engn, Charlotte, NC 28223 USA.
[Miu, Karen; Nwankpa, Chika] Drexel Univ, Elect & Comp Engn Dept, Philadelphia, PA 19104 USA.
[Basu, Megha] Siemens Inc, Washington, DC USA.
RP Leger, AS (reprint author), US Mil Acad, Dept Elect Engn & Comp Sci, West Point, NY 10996 USA.
EM aaron.stleger@usma.edu; vcecchi@uncc.edu; karen@ece.drexel.edu;
con22@drexel.edu
FU ONR [N0014-04-1-0404]
FX This work was supported by ONR N0014-04-1-0404. The views expressed
herein are those of the authors and do not reflect the position of the
United States Military Academy, the Department of the Army, or the
Department of Defense.
NR 27
TC 0
Z9 0
U1 18
U2 30
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0263-2241
EI 1873-412X
J9 MEASUREMENT
JI Measurement
PD OCT
PY 2016
VL 92
BP 1
EP 10
DI 10.1016/j.measurement.2016.05.064
PG 10
WC Engineering, Multidisciplinary; Instruments & Instrumentation
SC Engineering; Instruments & Instrumentation
GA DS4FL
UT WOS:000380736700001
ER
PT J
AU Panayotov, D
McEntee, M
Burrows, S
Driscoll, D
Tang, WJ
Neurock, M
Morris, J
AF Panayotov, Dimitar
McEntee, Monica
Burrows, Steve
Driscoll, Darren
Tang, Wenjie
Neurock, Matthew
Morris, John
TI Infrared studies of propene and propene oxide adsorption on
nanoparticulate Au/TiO2
SO SURFACE SCIENCE
LA English
DT Article
DE Propene; Propene oxide; Adsorption; Au/TiO2; Infrared spectroscopy;
Density functional theory
ID CONDUCTION-BAND ELECTRONS; GOLD-TITANIA CATALYSTS; GAS-PHASE
EPOXIDATION; AUGMENTED-WAVE METHOD; CO OXIDATION; IR SPECTROSCOPY;
PROPYLENE EPOXIDATION; AU NANOPARTICLES; CARBON-MONOXIDE; ETHYLENE-OXIDE
AB Direct gas-phase epoxidation of propene to propene oxide over a heterogeneous catalyst holds the potential to revolutionize production of one of the world's major commodity chemicals. New research into fundamental aspects of propene chemistry on nanoparticulate catalysts will help guide strategies for materials development. In the current study, Fourier transform infrared (FTIR) spectroscopy and density functional theory (DFT) have been employed to explore the molecular-level details of propene and propene oxide binding at a Au/TiO2 catalyst. Competitive binding studies for propene and carbon monoxide reveal that propene readily displaces CO from: first, interfacial Au parallel to TiO2 sites, then low coordinated Au sites at particulate corners and edges, and finally terrace regions of the particles. DFT calculations show that the C=C bond of propene weakens upon coordination to Au, which suggests that these sites may activate the molecule for epoxidation. Like propene, propene oxide adsorbs on both Au sites and Ti sites. In addition, Ti-OH sites also readily bind the oxide. However, competitive binding experiments show that the propene oxide adsorption is favored relative to propene on all sites, which would likely passivate the, catalyst at room temperature. (C) 2016 Published by Elsevier B.V.
C1 [Panayotov, Dimitar] Bulgarian Acad Sci, Inst Gen & Inorgan Chem, BU-1113 Sofia, Bulgaria.
[McEntee, Monica] US Army, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA.
[Burrows, Steve; Driscoll, Darren; Morris, John] Virginia Tech, Dept Chem, Blacksburg, VA 24061 USA.
[Tang, Wenjie; Neurock, Matthew] Univ Minnesota, Dept Chem Engn & Mat Sci, Minneapolis, MN 55455 USA.
RP Morris, J (reprint author), Virginia Tech, Dept Chem, Blacksburg, VA 24061 USA.
EM jrmorris@vt.edu
OI Driscoll, Darren/0000-0001-8859-8016
FU U.S. Army Research Laboratory; U. S. Army Research Office
[W911NF-14-1-0159]; ORAU for an ORISE fellowship
FX Our inspiration for this work and collaboration is all due to John T.
Yates, Jr. and his significant advancements in this field of study. We
thank him for his love of science and his ability to measure and produce
clear and detailed studies for future advancements. This material is
based upon work supported in part by the U.S. Army Research Laboratory
and the U. S. Army Research Office under contract number
W911NF-14-1-0159. We also gratefully thank the XSEDE computing resources
from Texas Advanced Computing Center and San Diego Supercomputer Center
for all of the DFT calculations. Lastly, we thank ORAU for an ORISE
fellowship for Monica McEntee.
NR 73
TC 2
Z9 2
U1 40
U2 50
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0039-6028
EI 1879-2758
J9 SURF SCI
JI Surf. Sci.
PD OCT
PY 2016
VL 652
SI SI
BP 172
EP 182
DI 10.1016/j.susc.2016.03.033
PG 11
WC Chemistry, Physical; Physics, Condensed Matter
SC Chemistry; Physics
GA DS2LJ
UT WOS:000380600700024
ER
PT J
AU Leonardi, W
Zilbermintz, L
Cheng, LW
Zozaya, J
Tran, SH
Elliott, JH
Polukhina, K
Manasherob, R
Li, A
Chi, XL
Gharaibeh, D
Kenny, T
Zamani, R
Soloveva, V
Haddow, AD
Nasar, F
Bavari, S
Bassik, MC
Cohen, SN
Levitin, A
Martchenko, M
AF Leonardi, William
Zilbermintz, Leeor
Cheng, Luisa W.
Zozaya, Josue
Tran, Sharon H.
Elliott, Jeffrey H.
Polukhina, Kseniya
Manasherob, Robert
Li, Amy
Chi, Xiaoli
Gharaibeh, Dima
Kenny, Tara
Zamani, Rouzbeh
Soloveva, Veronica
Haddow, Andrew D.
Nasar, Farooq
Bavari, Sina
Bassik, Michael C.
Cohen, Stanley N.
Levitin, Anastasia
Martchenko, Mikhail
TI Bithionol blocks pathogenicity of bacterial toxins, ricin, and Zika
virus
SO SCIENTIFIC REPORTS
LA English
DT Article
ID PSEUDOMONAS-AERUGINOSA EXOTOXIN; ANTHRAX LETHAL; CELL-DEATH; ACTIVATION;
SUSCEPTIBILITY; POLYMORPHISMS; APOPTOSIS; NEUROTOXINS; INVOLVEMENT;
DISEASE
AB Diverse pathogenic agents often utilize overlapping host networks, and hub proteins within these networks represent attractive targets for broad-spectrum drugs. Using bacterial toxins, we describe a new approach for discovering broad-spectrum therapies capable of inhibiting host proteins that mediate multiple pathogenic pathways. This approach can be widely used, as it combines genetic-based target identification with cell survival-based and protein function-based multiplex drug screens, and concurrently discovers therapeutic compounds and their protein targets. Using B-lymphoblastoid cells derived from the HapMap Project cohort of persons of African, European, and Asian ancestry we identified host caspases as hub proteins that mediate the lethality of multiple pathogenic agents. We discovered that an approved drug, Bithionol, inhibits host caspases and also reduces the detrimental effects of anthrax lethal toxin, diphtheria toxin, cholera toxin, Pseudomonas aeruginosa exotoxin A, Botulinum neurotoxin, ricin, and Zika virus. Our study reveals the practicality of identifying host proteins that mediate multiple disease pathways and discovering broad-spectrum therapies that target these hub proteins.
C1 [Leonardi, William; Zilbermintz, Leeor; Zozaya, Josue; Tran, Sharon H.; Elliott, Jeffrey H.; Polukhina, Kseniya; Levitin, Anastasia; Martchenko, Mikhail] Keck Grad Inst, Claremont, CA 91711 USA.
[Cheng, Luisa W.] USDA, Foodborne Toxin Detect & Prevent Res Unit, Western Reg Res Ctr, Albany, CA 94710 USA.
[Manasherob, Robert; Li, Amy; Bassik, Michael C.; Cohen, Stanley N.] Stanford Univ, Sch Med, Dept Genet, Stanford, CA 94305 USA.
[Chi, Xiaoli; Gharaibeh, Dima; Kenny, Tara; Zamani, Rouzbeh; Soloveva, Veronica; Haddow, Andrew D.; Nasar, Farooq; Bavari, Sina] US Army, Med Res Inst Infect Dis, USAMRIID, Ft Detrick, MD 21702 USA.
[Soloveva, Veronica] Henry M Jackson Fdn, Bethesda, MD 20817 USA.
[Soloveva, Veronica] Biotechnol High Performance Comp Software Applica, Frederick, MD 21702 USA.
RP Martchenko, M (reprint author), Keck Grad Inst, Claremont, CA 91711 USA.
EM mikhail_martchenko@kgi.edu
FU Kenneth T. and Eileen L. Norris Foundation
FX We thank Dr. Stephen Leppla of the NIAID for a kind gift of FP59 toxin.
A.L. acknowledges support from The Kenneth T. and Eileen L. Norris
Foundation.
NR 40
TC 0
Z9 0
U1 6
U2 6
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD SEP 30
PY 2016
VL 6
AR 34475
DI 10.1038/srep34475
PG 12
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA DX3RR
UT WOS:000384291100001
PM 27686742
ER
PT J
AU Allen, JL
Allen, JL
Thompson, T
Delp, SA
Wolfenstine, J
Jow, TR
AF Allen, Jan L.
Allen, Joshua L.
Thompson, Travis
Delp, Samuel A.
Wolfenstine, Jeff
Jow, T. Richard
TI Cr and Si Substituted-LiCo0.9Fe0.1PO4: Structure, full and half Li-ion
cell performance
SO JOURNAL OF POWER SOURCES
LA English
DT Article
DE Li-ion battery; Full cell; High voltage; Cathode; LiCoPO4
ID IMPROVED CYCLING PERFORMANCE; FE-SUBSTITUTED LICOPO4;
TRIS(TRIMETHYLSILYL) PHOSPHITE; DISCHARGE CAPACITY; LITHIUM BATTERIES;
ELECTROLYTE; CATHODES; LIFEPO4
AB The use of LiCoPO4 as a Li-ion cathode material can enable high energy 5 V batteries. However, LiCoPO4 shows limited cycle life and much less than theoretical energy density. In order to address these shortcomings, Fe, Cr and Si substituted-LiCoPO4 (Cr,Si-LiCo(0.9)FemPO(4)) was investigated as an improved LiCoPO4 based cathode material. Fe substitution greatly improves the cycle life and increases the energy density. Cr substitution further increases the energy density, cycle life and rate capability. Si substitution reduces the reactivity of the cathode with electrolyte thereby increasing cycle life. In combination, the substituents lead to a LiCoPO4 based cathode material with no capacity fade over 250 cycles in Li/Cr,Si-LiCo0,9Fe0.1PO4 half cells, a discharge capacity of 140 mAh g(-1), at C/3 at an average discharge voltage of 4.78 V giving an energy density of 670 Wh per kg of cathode. In graphite/Cr,Si-LiCo0.9Fe0.1PO4 full Li-ion cells, the cathode material shows an energy density of 550 Wh per kg of cathode material at 1C rate for the initial cycles and 510 Wh per kg of cathode material at the 250th cycle. Published by Elsevier B.V.
C1 [Allen, Jan L.; Allen, Joshua L.; Delp, Samuel A.; Wolfenstine, Jeff; Jow, T. Richard] US Army Res Lab, Sensors & Electron Devices Directorate, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
[Thompson, Travis] Univ Michigan, Dept Mech Engn, GG Brown Lab, 2350 Hayward Ave, Ann Arbor, MI 48109 USA.
RP Allen, JL (reprint author), US Army Res Lab, Sensors & Electron Devices Directorate, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM jan.l.allen8.civ@mail.mil
OI Allen, Jan/0000-0003-3353-1142
FU Army Research Laboratory; Army Research Laboratory postdoctoral program
through Oak Ridge Associated Universities
FX The authors acknowledge the Army Research Laboratory for funding. Saft
America provided graphite anodes. SAD was funded by the Army Research
Laboratory postdoctoral program administered through Oak Ridge
Associated Universities.
NR 42
TC 1
Z9 1
U1 35
U2 35
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-7753
EI 1873-2755
J9 J POWER SOURCES
JI J. Power Sources
PD SEP 30
PY 2016
VL 327
BP 229
EP 234
DI 10.1016/j.jpowsour.2016.07.055
PG 6
WC Chemistry, Physical; Electrochemistry; Energy & Fuels; Materials
Science, Multidisciplinary
SC Chemistry; Electrochemistry; Energy & Fuels; Materials Science
GA DV5XI
UT WOS:000383003600026
ER
PT J
AU Thomas, SJ
L'Azou, M
Barrett, ADT
Jackson, NAC
AF Thomas, Stephen J.
L'Azou, Maina
Barrett, Alan D. T.
Jackson, Nicholas A. C.
TI Fast-Track Zika Vaccine Development - Is It Possible?
SO NEW ENGLAND JOURNAL OF MEDICINE
LA English
DT Editorial Material
C1 [Thomas, Stephen J.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA.
[L'Azou, Maina; Jackson, Nicholas A. C.] Sanofi Pasteur, Lyon, France.
[Barrett, Alan D. T.] Univ Texas Med Branch, Sealy Ctr Vaccine Dev, Galveston, TX 77555 USA.
[Barrett, Alan D. T.] Univ Texas Med Branch, Dept Pathol, Galveston, TX 77555 USA.
RP Thomas, SJ (reprint author), Walter Reed Army Inst Res, Silver Spring, MD 20910 USA.
NR 5
TC 6
Z9 6
U1 5
U2 5
PU MASSACHUSETTS MEDICAL SOC
PI WALTHAM
PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA
SN 0028-4793
EI 1533-4406
J9 NEW ENGL J MED
JI N. Engl. J. Med.
PD SEP 29
PY 2016
VL 375
IS 13
BP 1212
EP 1216
DI 10.1056/NEJMp1609300
PG 5
WC Medicine, General & Internal
SC General & Internal Medicine
GA DX3HU
UT WOS:000384265000002
PM 27682032
ER
PT J
AU Taylor, DE
Angyan, JG
Galli, G
Zhang, C
Gygi, F
Hirao, K
Song, JW
Rahul, K
von Lilienfeld, OA
Podeszwa, R
Bulik, IW
Henderson, TM
Scuseria, GE
Toulouse, J
Peverati, R
Truhlar, DG
Szalewicz, K
AF Taylor, DeCarlos E.
Angyan, Janos G.
Galli, Giulia
Zhang, Cui
Gygi, Francois
Hirao, Kimihiko
Song, Jong Won
Rahul, Kar
von Lilienfeld, O. Anatole
Podeszwa, Rafat
Bulik, Ireneusz W.
Henderson, Thomas M.
Scuseria, Gustavo E.
Toulouse, Julien
Peverati, Roberto
Truhlar, Donald G.
Szalewicz, Krzysztof
TI Blind test of density-functional-based methods on intermolecular
interaction energies
SO JOURNAL OF CHEMICAL PHYSICS
LA English
DT Article
ID GENERALIZED-GRADIENT-APPROXIMATION; ADAPTED PERTURBATION-THEORY;
KOHN-SHAM ORBITALS; EXCHANGE-CORRELATION ENERGY; INHOMOGENEOUS
ELECTRON-GAS; DER-WAALS COMPLEXES; BASIS-SETS; DISPERSION ENERGIES;
NONCOVALENT INTERACTIONS; CONSTRAINT SATISFACTION
AB In the past decade, a number of approaches have been developed to fix the failure of (semi) local density-functional theory (DFT) in describing intermolecular interactions. The performance of several such approaches with respect to highly accurate benchmarks is compared here on a set of separation-dependent interaction energies for ten dimers. Since the benchmarks were unknown before the DFT-based results were collected, this comparison constitutes a blind test of these methods.
C1 [Taylor, DeCarlos E.] US Army, Res Lab, Aberdeen, MD 21005 USA.
[Angyan, Janos G.] CNRS, CRM2, UMR 7036, F-54506 Vandoeuvre Les Nancy, France.
[Angyan, Janos G.] Univ Lorraine, CRM2, UMR 7036, F-54506 Vandoeuvre Les Nancy, France.
[Galli, Giulia] Univ Chicago, Inst Mol Engn, Chicago, IL 60637 USA.
[Zhang, Cui] Univ Calif Davis, Dept Chem, Davis, CA 95616 USA.
[Gygi, Francois] Univ Calif Davis, Dept Comp Sci, Davis, CA 95616 USA.
[Hirao, Kimihiko; Song, Jong Won; Rahul, Kar] RIKEN Adv Inst Computat Sci, Computat Chem Unit, Kobe, Hyogo 6500047, Japan.
[von Lilienfeld, O. Anatole] Free Univ Brussels VUB, Gen Chem ALGC, Pl Laan 2, B-1050 Brussels, Belgium.
[von Lilienfeld, O. Anatole] Univ Basel, Inst Phys Chem, CH-4056 Basel, Switzerland.
[von Lilienfeld, O. Anatole] Univ Basel, Natl Ctr Computat Design & Discovery Novel Mat MA, Dept Chem, CH-4056 Basel, Switzerland.
[Podeszwa, Rafat] Univ Silesia, Inst Chem, Szkolna 9, PL-40006 Katowice, Poland.
[Bulik, Ireneusz W.; Henderson, Thomas M.; Scuseria, Gustavo E.] Rice Univ, Dept Chem, POB 1892, Houston, TX 77005 USA.
[Toulouse, Julien] Univ Paris 06, CNRS, Sorbonne Univ, Lab Chim Theor, F-75005 Paris, France.
[Peverati, Roberto; Truhlar, Donald G.] Univ Minnesota, Dept Chem, 207 Pleasant St SE, Minneapolis, MN 55455 USA.
[Peverati, Roberto] Florida Inst Technol, Dept Chem, Melbourne, FL 32901 USA.
[Szalewicz, Krzysztof] Univ Delaware, Dept Phys & Astron, Newark, DE 19716 USA.
RP Taylor, DE (reprint author), US Army, Res Lab, Aberdeen, MD 21005 USA.
RI Toulouse, Julien/A-1376-2010;
OI Truhlar, Donald/0000-0002-7742-7294
FU NSF [CHE-1152899]; National Science Centre, Poland
[2015/17/B/ST4/03727]; U.S. Department of Energy, Office of Basic Energy
Sciences, Computational and Theoretical Chemistry Program
[DE-FG02-09ER16053]; Welch Foundation Chair [C-0036]; Department of
Energy/Basic Energy Sciences Grant [DE-FG02-06ER46262]; Department of
Energy Basic Energy Sciences [DE-SC0008938]; ARO
FX The ARL-UD workshop that led to the present paper was funded by ARO. We
thank Dr. James Parker and Dr. Betsy Rice for their encouragement and
constant support of this work. We thank Dr. Edoardo Apra and Dr. Karol
Kowalski for fixing the errors in NWChem found by us. K.S. was partly
supported by NSF Grant No. CHE-1152899. R.P. acknowledges support from
the National Science Centre, Poland, Grant No. 2015/17/B/ST4/03727. The
work at Rice University was supported by the U.S. Department of Energy,
Office of Basic Energy Sciences, Computational and Theoretical Chemistry
Program under Award No. DE-FG02-09ER16053. G.E.S. is a Welch Foundation
Chair (Grant No. C-0036). C.Z. and G.G. were supported by Department of
Energy/Basic Energy Sciences Grant No. DE-FG02-06ER46262. F.G.
acknowledges support from Department of Energy Basic Energy Sciences
Grant No. DE-SC0008938.
NR 104
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Z9 2
U1 21
U2 21
PU AMER INST PHYSICS
PI MELVILLE
PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA
SN 0021-9606
EI 1089-7690
J9 J CHEM PHYS
JI J. Chem. Phys.
PD SEP 28
PY 2016
VL 145
IS 12
AR 124105
DI 10.1063/1.4961095
PG 19
WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical
SC Chemistry; Physics
GA DZ0XI
UT WOS:000385562600007
PM 27782652
ER
PT J
AU Nykaza, JR
Savage, AM
Pan, QW
Wang, SJ
Beyer, FL
Tang, MH
Li, CY
Elabd, YA
AF Nykaza, Jacob R.
Savage, Alice M.
Pan, Qiwei
Wang, Shijun
Beyer, Frederick L.
Tang, Maureen H.
Li, Christopher Y.
Elabd, Yossef A.
TI Polymerized ionic liquid diblock copolymer as solid-state electrolyte
and separator in lithium-ion battery
SO POLYMER
LA English
DT Article
DE Ionic liquid; Block copolymer; Membrane
ID TEMPERATURE MOLTEN-SALTS; BLOCK-COPOLYMER; HYDROXIDE CONDUCTIVITY;
RADICAL POLYMERIZATION; MOLECULAR-WEIGHT; METAL BATTERIES; MORPHOLOGY;
PERFORMANCE; CHALLENGES; DEVICES
AB A polymerized ionic liquid diblock copolymer (PILBCP-TFSI), poly(MMA-b-MUBIm-TFSI), consisting of an ionic liquid monomer, (1-[(2-methacryloyloxy)undecyl]-3-butylimidazolium bis(trifluoromethane)sulfonamide) (MUBIm-TFSI), and a non-ionic monomer, methyl methacrylate (MMA), was synthesized via reverse addition fragmentation chain transfer polymerization followed by anion exchange metathesis. Free standing, mechanically stable transparent solid polymer films were produced with PILBCP-TFSI containing 1 M lithium bis(trifluoromethane)sulfonamide in 1-ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide (Li-TFSI/EMIm-TFSI). The resulting PILBCP-TFSI + Li-TFSI/EMIm-TFSI films possessed ion conductivities from 1 to 10 mS cm(-1) from 25 degrees C to 105 degrees C. Solid-state lithium -ion coin cell batteries were assembled and tested at room temperature with PILBCP-TFSI + Li-TFSI/EMIm-TFSI films as the solid-state electrolyte and separator and resulted in a maximum discharge capacity of 112 mAh g(-1) at 0.1 C with a Coulombic efficiency greater than 94% over 100 cycles. For the first time, these results demonstrate the feasibility of PIL block copolymers as solid-state electrolytes and separators in lithium ion batteries. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Nykaza, Jacob R.; Tang, Maureen H.] Drexel Univ, Dept Chem & Biol Engn, Philadelphia, PA 19104 USA.
[Savage, Alice M.; Beyer, Frederick L.] Army Res Lab, Aberdeen Proving Ground, MD 21005 USA.
[Pan, Qiwei; Wang, Shijun; Li, Christopher Y.] Drexel Univ, Dept Mat Sci & Engn, Philadelphia, PA 19104 USA.
[Elabd, Yossef A.] Texas A&M Univ, Dept Chem Engn, College Stn, TX 77843 USA.
RP Elabd, YA (reprint author), Texas A&M Univ, Dept Chem Engn, College Stn, TX 77843 USA.
EM elabd@tamu.edu
RI Elabd, Yossef/G-9866-2014
OI Elabd, Yossef/0000-0002-7790-9445
FU U.S. Army Research Office [W911NF-14-0310]; Postgraduate Research
Participation Program at the US Army Research Laboratory
[ORISE1120-1120-99]
FX This work is supported in part by the U.S. Army Research Office under
grant no. W911NF-14-0310. A.M.S. was supported by the Postgraduate
Research Participation Program at the US Army Research Laboratory,
administered by the Oak Ridge Institute of Science and Education through
an interagency agreement between the U.S. Department of Energy and Army
Research Laboratory (Contract ORISE1120-1120-99). Special thanks to
Bryan Byles in the Drexel University materials engineering department
for assistance with fabricating the coin cell anodes.
NR 49
TC 0
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U1 51
U2 51
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0032-3861
EI 1873-2291
J9 POLYMER
JI Polymer
PD SEP 28
PY 2016
VL 101
BP 311
EP 318
DI 10.1016/j.polymer.2016.08.100
PG 8
WC Polymer Science
SC Polymer Science
GA DY0KD
UT WOS:000384784800034
ER
PT J
AU Pilkiewicz, KR
Mayo, ML
AF Pilkiewicz, Kevin R.
Mayo, Michael L.
TI Fluctuation sensitivity of a transcriptional signaling cascade
SO PHYSICAL REVIEW E
LA English
DT Article
ID REGULATORY CASCADES; ESCHERICHIA-COLI; GENE-REGULATION; NETWORK;
SIMULATION; EXPRESSION; KINETICS; QUANTIFICATION
AB The internal biochemical state of a cell is regulated by a vast transcriptional network that kinetically correlates the concentrations of numerous proteins. Fluctuations in protein concentration that encode crucial information about this changing state must compete with fluctuations caused by the noisy cellular environment in order to successfully transmit information across the network. Oftentimes, one protein must regulate another through a sequence of intermediaries, and conventional wisdom, derived from the data processing inequality of information theory, leads us to expect that longer sequences should lose more information to noise. Using the metric of mutual information to characterize the fluctuation sensitivity of transcriptional signaling cascades, we find, counter to this expectation, that longer chains of regulatory interactions can instead lead to enhanced informational efficiency. We derive an analytic expression for the mutual information from a generalized chemical kinetics model that we reduce to simple, mass-action kinetics by lincarizing for small fluctuations about the basal biological steady state, and we find that at long times this expression depends only on a simple ratio of protein production to destruction rates and the length of the cascade. We place bounds on the values of these parameters by requiring that the mutual information be at least one bit-otherwise, any received signal would be indistinguishable from noise-and we find not only that nature has devised a way to circumvent the data processing inequality, but that it must be circumvented to attain this one-bit threshold. We demonstrate how this result places informational and biochemical efficiency at odds with one another by correlating high transcription factor binding affinities with low informational output, and we conclude with an analysis of the validity of our assumptions and propose how they might be tested experimentally.
C1 [Pilkiewicz, Kevin R.; Mayo, Michael L.] US Army Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
RP Pilkiewicz, KR (reprint author), US Army Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
FU U.S. Army's Environmental Quality and Installations 6.1 Basic Research
program
FX Funding was provided by the U.S. Army's Environmental Quality and
Installations 6.1 Basic Research program. Opinions, interpretations,
conclusions, and recommendations are those of the author(s) and are not
necessarily endorsed by the U.S. Army. The authors would also like to
thank Professor Hans C. Andersen at Stanford University for insightful
discussions.
NR 36
TC 0
Z9 0
U1 3
U2 3
PU AMER PHYSICAL SOC
PI COLLEGE PK
PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA
SN 2470-0045
EI 2470-0053
J9 PHYS REV E
JI Phys. Rev. E
PD SEP 27
PY 2016
VL 94
IS 3
AR 032412
DI 10.1103/PhysRevE.94.032412
PG 13
WC Physics, Fluids & Plasmas; Physics, Mathematical
SC Physics
GA DX0TR
UT WOS:000384078600006
PM 27739739
ER
PT J
AU Kuschner, RA
AF Kuschner, Robert A.
TI Aspirin and Acute Respiratory Distress Syndrome
SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
LA English
DT Letter
C1 [Kuschner, Robert A.] Walter Reed Army Inst Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
RP Kuschner, RA (reprint author), Walter Reed Army Inst Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM robert.a.kuschner.mil@mail.mil
NR 3
TC 0
Z9 0
U1 0
U2 0
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 0098-7484
EI 1538-3598
J9 JAMA-J AM MED ASSOC
JI JAMA-J. Am. Med. Assoc.
PD SEP 27
PY 2016
VL 316
IS 12
BP 1317
EP 1318
PG 2
WC Medicine, General & Internal
SC General & Internal Medicine
GA DW9EW
UT WOS:000383959800027
PM 27673312
ER
PT J
AU Das, D
Sanchez, L
Martin, J
Power, B
Isaacson, S
Polcawich, RG
Chasiotis, I
AF Das, Debashish
Sanchez, Luz
Martin, Joel
Power, Brian
Isaacson, Steven
Polcawich, Ronald G.
Chasiotis, Ioannis
TI Control of mechanical response of freestanding PbZr0.52Ti0.48O3 films
through texture
SO APPLIED PHYSICS LETTERS
LA English
DT Article
ID LEAD-ZIRCONATE-TITANATE; FERROELECTRIC THIN-FILMS; DOMAIN-WALL MOTION;
PIEZOELECTRIC PROPERTIES; MICROELECTROMECHANICAL SYSTEMS; ORIENTATION
DEPENDENCE; SWITCHING MODEL; SEED LAYERS; CERAMICS; ACTUATORS
AB The texture of piezoelectric lead zirconate titanate (PZT) thin films plays a key role in their mechanical response and linearity in the stress vs. strain behavior. The open circuit mechanical properties of PZT films with controlled texture varying from 100% (001) to 100% (111) were quantified with the aid of direct strain measurements from freestanding thin film specimens. The texture was tuned using a highly {111}-textured Pt substrate and excess-Pb in the PbTiO3 seed layer. The mechanical and ferroelastic properties of 500 nm thick PZT (52/48) films were found to be strongly dependent on grain orientation: the lowest elastic modulus of 90 +/- 62GPa corresponded to pure (001) texture, and its value increased linearly with the percentage of (111) texture reaching 122 +/- 3GPa for pure (111) texture. These elastic modulus values were between those computed for transversely isotropic textured PZT films by using the soft and hard bulk PZT compliance coefficients. Pure (001) texture exhibited maximum non-linearity and ferroelastic domain switching, contrary to pure (111) texture that exhibited more linearity and the least amount of switching. A micromechanics model was employed to calculate the strain due to domain switching. The model fitted well the non-linearities in the experimental stress-strain curves of (001) and (111) textured PZT films, predicting 17% and 10% of switched 90 degrees domains that initially were favorably aligned with the applied stress in (001) and (111) textured PZT films, respectively. Published by AIP Publishing.
C1 [Das, Debashish; Chasiotis, Ioannis] Univ Illinois, Aerosp Engn, Urbana, IL 61801 USA.
[Sanchez, Luz; Martin, Joel; Power, Brian; Polcawich, Ronald G.] US Army Res Lab, Adelphi, MD 20783 USA.
[Isaacson, Steven] Gen Tech Serv, Wall, NJ 07719 USA.
RP Das, D (reprint author), Univ Illinois, Aerosp Engn, Urbana, IL 61801 USA.
FU ARO [W911NF-12-1-0204]
FX The authors acknowledge the support by the ARO Grant No.
W911NF-12-1-0204, with Dr. Larry Russell and Dr. Asher Rubinstein as the
program managers. SEM and X-ray studies were carried out at the
Frederick Seitz Materials Research Laboratory Central Research
Facilities of the University of Illinois.
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U1 18
U2 18
PU AMER INST PHYSICS
PI MELVILLE
PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA
SN 0003-6951
EI 1077-3118
J9 APPL PHYS LETT
JI Appl. Phys. Lett.
PD SEP 26
PY 2016
VL 109
IS 13
AR 131905
DI 10.1063/1.4963348
PG 5
WC Physics, Applied
SC Physics
GA DX9WO
UT WOS:000384747900017
ER
PT J
AU Hu, WG
Patil, NV
Hsieh, AJ
AF Hu, Weiguo
Patil, Nitin V.
Hsieh, Alex J.
TI Glass transition of soft segments in phase-mixed poly(urethane urea)
elastomers by time-domain H-1 and C-13 solid-state NMR
SO POLYMER
LA English
DT Article
DE Poly(urethane urea); Solid-state NMR; Glass transition
ID SPIN-LATTICE-RELAXATION; X-RAY-SCATTERING; PROTON NMR; MICRODOMAIN
STRUCTURE; CROSS-POLARIZATION; POLYURETHANE; POLYETHYLENE; DIFFUSION;
DYNAMICS; SPECTROSCOPY
AB The glass transition processes of the soft-segments (SS) in a series of poly(urethane urea) (PUU) elastomers were studied by solid-state NMR. Two SS fractions, rigid (SSr) and mobile (SSm), can be discerned by time-domain wideline separation, C-13-H-1 dipolar dephasing, and frequency-switched Lee-Goldberg spin-locked T-1p relaxation experiments. At increasing temperature, part of the SSr population turns into SSm, while the decay constants of both fractions only see moderate changes. The extent of the population exchange is greater for samples with more phase mixing. This population exchange can be interpreted as the glass transition in the SS-rich domains. Comparison between T-1p relaxations on the xy plane and along the magic angle indicates that the domain sizes of SSr and SSm are likely less than 2-3 nm. SSr is not completely rigid, but possesses both a fast, anisotropic chain rotation associated with the beta relaxation and a slower motion with more isotropic nature at ca. 10(5) s(-1). It is predicted that at high strain rates, most of SSr and part of SSm would become rigid, resulting in dynamically induced strengthening and toughening. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Hu, Weiguo; Patil, Nitin V.] Univ Massachusetts, Dept Polymer Sci & Engn, Amherst, MA 01003 USA.
[Hsieh, Alex J.] US Army Res Lab, RDRL WMM G, Aberdeen Proving Ground, MD 21005 USA.
[Patil, Nitin V.] Reichhold Inc, 1035 Swabia Court, Durham, NC 27703 USA.
RP Hu, WG (reprint author), Univ Massachusetts, Dept Polymer Sci & Engn, Amherst, MA 01003 USA.
EM whu@data.pse.umass.edu
FU U.S. Army Research Laboratory; U. S. Army Research Office
[W911NF-14-1-0204, W911NF-15-1-0534]
FX This manuscript is based upon work supported by the U.S. Army Research
Laboratory and the U. S. Army Research Office under grant numbers
W911NF-14-1-0204 and W911NF-15-1-0534.
NR 47
TC 0
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U1 9
U2 9
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0032-3861
EI 1873-2291
J9 POLYMER
JI Polymer
PD SEP 25
PY 2016
VL 100
BP 149
EP 157
DI 10.1016/j.polymer.2016.08.015
PG 9
WC Polymer Science
SC Polymer Science
GA DW8SM
UT WOS:000383925800019
ER
PT J
AU Woo, HJ
Yu, CG
Kumar, K
Gold, B
Reifman, J
AF Woo, Hyung Jun
Yu, Chenggang
Kumar, Kamal
Gold, Bert
Reifman, Jaques
TI Genotype distribution-based inference of collective effects in
genome-wide association studies: insights to age-related macular
degeneration disease mechanism (vol 17, pg 695, 2016)
SO BMC GENOMICS
LA English
DT Correction
C1 [Woo, Hyung Jun; Yu, Chenggang; Kumar, Kamal; Reifman, Jaques] US Army Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Biotechnol High Performance Comp Software Applica, Ft Detrick, MD USA.
[Gold, Bert] NCI, Lab Genom Div, Frederick, MD 21701 USA.
RP Reifman, J (reprint author), US Army Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Biotechnol High Performance Comp Software Applica, Ft Detrick, MD USA.
EM jaques.reifman.civ@mail.mil
NR 1
TC 0
Z9 0
U1 1
U2 1
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2164
J9 BMC GENOMICS
JI BMC Genomics
PD SEP 22
PY 2016
VL 17
DI 10.1186/s12864-016-3095-2
PG 2
WC Biotechnology & Applied Microbiology; Genetics & Heredity
SC Biotechnology & Applied Microbiology; Genetics & Heredity
GA DX4OP
UT WOS:000384361300001
ER
PT J
AU Waytowich, NR
Lawhern, VJ
Bohannon, AW
Ball, KR
Lance, BJ
AF Waytowich, Nicholas R.
Lawhern, Vernon J.
Bohannon, Addison W.
Ball, Kenneth R.
Lance, Brent J.
TI Spectral Transfer Learning Using Information Geometry for a
User-Independent Brain-Computer Interface
SO FRONTIERS IN NEUROSCIENCE
LA English
DT Article
DE unsupervised learning; ensemble learning; calibration-free BCI; P300;
RSVP
ID CALIBRATION TIME; CLASSIFICATION; KERNEL; BCI; FRAMEWORK; MATRICES
AB Recent advances in signal processing and machine learning techniques have enabled the application of Brain-Computer Interface (BCI) technologies to fields such as medicine, industry, and recreation; however, BCIs still suffer from the requirement of frequent calibration sessions due to the intra- and inter-individual variability of brain-signals, which makes calibration suppression through transfer learning an area of increasing interest for the development of practical BCI systems. In this paper, we present an unsupervised transfer method (spectral transfer using information geometry, STIG), which ranks and combines unlabeled predictions from an ensemble of information geometry classifiers built on data from individual training subjects. The STIG method is validated in both off-line and real-time feedback analysis during a rapid serial visual presentation task (RSVP). For detection of single-trial, event-related potentials (ERPs), the proposed method can significantly outperform existing calibration-free techniques as well as outperform traditional within-subject calibration techniques when limited data is available. This method demonstrates that unsupervised transfer learning for single-trial detection in ERR-based BCIs can be achieved without the requirement of costly training data, representing a step-forward in the overall goal of achieving a practical user-independent BCI system.
C1 [Waytowich, Nicholas R.; Lawhern, Vernon J.; Bohannon, Addison W.; Ball, Kenneth R.; Lance, Brent J.] US Army, Human Res & Engn Directorate, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
[Waytowich, Nicholas R.] Columbia Univ, Dept Biomed Engn, New York, NY 10027 USA.
[Lawhern, Vernon J.] Univ Texas San Antonio, Dept Comp Sci, San Antonio, TX USA.
[Bohannon, Addison W.] Univ Maryland, Appl Math Stat & Sci Computat Program, College Pk, MD 20742 USA.
RP Waytowich, NR (reprint author), US Army, Human Res & Engn Directorate, Res Lab, Aberdeen Proving Ground, MD 21005 USA.; Waytowich, NR (reprint author), Columbia Univ, Dept Biomed Engn, New York, NY 10027 USA.
EM nrw2106@columbia.edu
FU Office of the Secretary of Defense Autonomy Research Pilot Initiative
program [MIPR DWAM31168]; U.S. Army Research Laboratory
[W911NF-10-2-0022]
FX This project was supported by the Office of the Secretary of Defense
Autonomy Research Pilot Initiative program MIPR DWAM31168 and by the
U.S. Army Research Laboratory, under Cooperative Agreement Number
W911NF-10-2-0022. This research was also supported in part by an
appointment to the Student Research Participation Program at the U.S.
Army Research Laboratory administered by the Oak Ridge Institute for
Science and Education through an interagency agreement between the U.S.
Department of Energy and USARL. The views and the conclusions contained
in this document are those of the authors and should not he interpreted
as representing the official policies, either expressed or implied, of
the U.S Government. The U.S. Government is authorized to reproduce and
distribute reprints for Government purposes notwithstanding any
copyright notation herein.
NR 38
TC 0
Z9 0
U1 9
U2 9
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015,
SWITZERLAND
SN 1662-453X
J9 FRONT NEUROSCI-SWITZ
JI Front. Neurosci.
PD SEP 22
PY 2016
VL 10
AR 430
DI 10.3339/fnins.2076.00430
PG 15
WC Neurosciences
SC Neurosciences & Neurology
GA DW6MR
UT WOS:000383765800001
PM 27713685
ER
PT J
AU Sampaio, VS
Beltran, TP
Kobylinski, KC
Melo, GC
Lima, JBP
Silva, SGM
Rodriguez, IC
Silveira, H
Guerra, MGVB
Bassat, Q
Pimenta, PFP
Lacerda, MVG
Monteiro, WM
AF Sampaio, Vanderson S.
Beltran, Tatiana P.
Kobylinski, Kevin C.
Melo, Gisely C.
Lima, Jose B. P.
Silva, Sara G. M.
Rodriguez, Iria C.
Silveira, Henrique
Guerra, Maria G. V. B.
Bassat, Quique
Pimenta, Paulo F. P.
Lacerda, Marcus V. G.
Monteiro, Wuelton M.
TI Filling gaps on ivermectin knowledge: effects on the survival and
reproduction of Anopheles aquasalis, a Latin American malaria vector
SO MALARIA JOURNAL
LA English
DT Article
DE Malaria elimination; Vector control; Ivermectin; Anopheles aquasalis;
Amazon
ID PLASMODIUM-FALCIPARUM; ONCHOCERCA-VOLVULUS; RESEARCH AGENDA;
TRANSMISSION; GAMBIAE; ELIMINATION; BRAZIL; BLOOD; CULICIDAE; MOSQUITOS
AB Background: Strategies designed to advance towards malaria elimination rely on the detection and treatment of infections, rather than fever, and the interruption of malaria transmission between mosquitoes and humans. Mass drug administration with anti-malarials directed at eliminating parasites in blood, either to entire populations or targeting only those with malaria infections, are considered useful strategies to progress towards malaria elimination, but may be insufficient if applied on their own. These strategies assume a closer contact with populations, so incorporating a vector control intervention tool to those approaches could significantly enhance their efficacy. Ivermectin, an endectocide drug efficacious against a range of Anopheles species, could be added to other drug-based interventions. Interestingly, ivermectin could also be useful to target outdoor feeding and resting vectors, something not possible with current vector control tools, such as impregnated bed nets or indoor residual spraying (IRS).
Results: Anopheles aquasalis susceptibility to ivermectin was assessed. In vivo assessments were performed in six volunteers, being three men and three women. The effect of ivermectin on reproductive fitness and mosquito survivorship using membrane feeding assay (MFA) and direct feeding assay (DFA) was assessed and compared. The ivermectin lethal concentration (LC) values were LC50 = 47.03 ng/ml [44.68-49.40], LC25 = 31.92 ng/ml [28.60-34.57] and LC5 = 18.28 ng/ml [14.51-21.45]. Ivermectin significantly reduced the survivorship of An. aquasalis blood-fed 4 h post-ingestion (X-2 [N = 880] = 328.16, p < 0.001), 2 days post-ingestion (DPI 2) (X-2 [N = 983] = 156.75, p < 0.001), DPI 7 (X-2 [N = 935] = 31.17, p < 0.001) and DPI 14 (X-2 [N = 898] = 38.63, p < 0.001) compared to the blood fed on the untreated control. The average number of oviposited eggs per female was significantly lower in LC5 group (22.44 [SD = 3.38]) than in control (34.70 [SD = 12.09]) (X-2 [N = 199] = 10.52, p < 0.001) as well as the egg hatch rate (LC5 = 74.76 [SD = 5.48]) (Control = 81.91 [SD = 5.92]) (X-2 [N = 124] = 64.24, p < 0.001). However, no differences were observed on the number of pupae that developed from larvae (Control = 34.19 [SD = 10.42) and group (LC5 = 33.33 [SD = 11.97]) (X-2 [N = 124] = 0.96, p > 0.05).
Conclusions: Ivermectin drug reduces mosquito survivorship when blood fed on volunteer blood from 4 h to 14 days post-ingestion controlling for volunteers' gender. Ivermectin at mosquito sub-lethal concentrations (LC5) reduces fecundity and egg hatch rate but not the number of pupae that developed from larvae. DFA had significantly higher effects on mosquito survival compared to MFA. The findings are presented and discussed through the prism of malaria elimination in the Amazon region.
C1 [Sampaio, Vanderson S.; Beltran, Tatiana P.; Silva, Sara G. M.; Rodriguez, Iria C.; Silveira, Henrique; Guerra, Maria G. V. B.; Pimenta, Paulo F. P.; Lacerda, Marcus V. G.; Monteiro, Wuelton M.] Fundacao Med Trop Dr Heitor Vieira Dourado, Diretoria Ensino & Pesquisa, Manaus, Amazonas, Brazil.
[Sampaio, Vanderson S.; Beltran, Tatiana P.; Melo, Gisely C.; Guerra, Maria G. V. B.; Monteiro, Wuelton M.] Univ Estado Amazonas, Escola Super Ciencias Saude, Manaus, Amazonas, Brazil.
[Sampaio, Vanderson S.] Fundacao Vigilancia Saude Amazonas, Sala Anal Situacao Saude, Manaus, Amazonas, Brazil.
[Kobylinski, Kevin C.] Armed Forces Res Inst Med Sci, Bangkok, Thailand.
[Lima, Jose B. P.] Fiocruz MS, Inst Oswaldo Cruz, Rio De Janeiro, Brazil.
[Silveira, Henrique] Univ Nova Lisboa, Inst Higiene & Med Trop, Lisbon, Portugal.
[Bassat, Quique] Univ Barcelona, ISGlobal, Barcelona Ctr Int Hlth Res CRESIB, Hosp Clin, Barcelona, Spain.
[Bassat, Quique] CISM, Maputo, Mozambique.
[Pimenta, Paulo F. P.] Fiocruz MS, Ctr Pesquisas Rene Rachou, Belo Horizonte, MG, Brazil.
[Lacerda, Marcus V. G.] Fiocruz MS, Inst Pesquisas Leonidas & Maria Deane, Manaus, Amazonas, Brazil.
RP Sampaio, VS (reprint author), Fundacao Med Trop Dr Heitor Vieira Dourado, Diretoria Ensino & Pesquisa, Manaus, Amazonas, Brazil.; Sampaio, VS (reprint author), Univ Estado Amazonas, Escola Super Ciencias Saude, Manaus, Amazonas, Brazil.; Sampaio, VS (reprint author), Fundacao Vigilancia Saude Amazonas, Sala Anal Situacao Saude, Manaus, Amazonas, Brazil.
EM vandersons@gmail.com
FU Oswaldo Cruz Foundation (FIOCRUZ); National Counsel of Technological and
Scientific Development (CNPq); Coordination for the Improvement of
Higher Education Personnel (CAPES); Research Support Foundation of Minas
Gerais (FAPEMIG); Research Support Foundation of Amazonas (FAPEAM)
through PPSUS project; Bill & Melinda Gates Foundation through TransEpi
Project; programme Miguel Servet of the ISCIII (Plan Nacional de I+D+I)
[CP11/00269]
FX Oswaldo Cruz Foundation (FIOCRUZ), National Counsel of Technological and
Scientific Development (CNPq), Coordination for the Improvement of
Higher Education Personnel (CAPES), Research Support Foundation of Minas
Gerais (FAPEMIG) and Research Support Foundation of Amazonas (FAPEAM)
through PPSUS project supported this study. Bill & Melinda Gates
Foundation has also funded this study through TransEpi Project. QB has a
fellowship from the programme Miguel Servet of the ISCIII (Plan Nacional
de I+D+I 2008-2011, Grant number: CP11/00269). PFPP and MVGL are level 1
fellows from CNPq. VSS and TPB have fellowships from CAPES.
NR 47
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U1 5
U2 5
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1475-2875
J9 MALARIA J
JI Malar. J.
PD SEP 22
PY 2016
VL 15
AR 491
DI 10.1186/s12936-016-1540-y
PG 9
WC Infectious Diseases; Parasitology; Tropical Medicine
SC Infectious Diseases; Parasitology; Tropical Medicine
GA DW5EU
UT WOS:000383666200004
ER
PT J
AU Temme, LA
St Onge, P
Bleiberg, J
AF Temme, Leonard A.
St Onge, Paul
Bleiberg, Joseph
TI A History of Mild Traumatic Brain Injury Affects Peripheral Pulse
Oximetry during Normobaric Hypoxia
SO FRONTIERS IN NEUROLOGY
LA English
DT Article
DE mild traumatic brain injury; normobaric hypoxia; pulse oximetry;
Functional Impairment Tester; oculometric; stress
ID OXYGEN BREATHING DEVICE; HEART-RATE-VARIABILITY; CONCUSSION; SPORT;
RESPONSES; EXERCISE; ALTITUDE; STRESS; HUMANS
AB Introduction: Physiological and emotional stressors increase symptoms of concussion in recently injured individuals and both forms of stress-induced symptoms in people recovering from mild traumatic brain injury (mTBI), but who are asymptomatic when not stressed or are at rest.
Methods: Healthy asymptomatic adults (25.0 +/- 5.1 years) with a history of mTBI (n = 36) and matched healthy controls (HC) (n = 36) with no mTBI history were exposed to three levels of normobaric hypoxic stress generated with the Reduced Oxygen Breathing Device (ROBD) (Environics, Inc., Tollande, CT, USA), which reduced the percent O-2 by mixing sea level air with nitrogen. The ROBD reduced the percent O-2 in the breathable air from the normal 21% to 15.5% O-2, 14% O-2, and 13% O-2. Under these conditions: (a) a standard pulse oximeter recorded peripheral oxygen saturation (SpO(2)) and pulse rate (beats per minute) and (b) the Functional Impairment Tester (FIT) (PMI, Inc., Rockville, MD, USA) recorded saccadic velocity and pupillary response dynamics to a brief light flash.
Results: For all three hypoxic stress conditions, the mTBI group had significantly higher SpO(2) during the final minute of exposure than did the controls [F(2.17,151.8) = 5.29, p < 0.001, eta(2) = 0.852] and the rate of SpO(2) change over time was significantly shallower for the mTBI than for the controls [F(2.3,161.3) = 2.863, p < 0.001, eta(2) = 0.569], Greenhouse-Geisser corrected. Overall, mTBI had lower pulse rate but the difference was only significant for the 14% O-2 condition. FIT oculomotor measures were not sensitive to group differences. When exposed to mild or moderate normobaric hypoxic stress (15% 02): (1) SpO(2) differences emerged between the mTBI and matched HC groups, (2) heart rate trended lower in the mTBI group, and (3) FIT measures were not sensitive to group differences.
Conclusion: A relatively minor hypoxic challenge can reveal measurable differences in SpO(2) and heart rate in otherwise asymptomatic individuals with a history of mTBI.
C1 [Temme, Leonard A.; St Onge, Paul] US Army, Aeromed Res Lab, Ft Rucker, AL 36362 USA.
[St Onge, Paul] Laulima Govt Solut LLC, Orlando, FL USA.
[Bleiberg, Joseph] Walter Reed Natl Army Med Ctr, Natl Intrepid Ctr Excellence, Bethesda, MD USA.
RP Temme, LA (reprint author), US Army, Aeromed Res Lab, Ft Rucker, AL 36362 USA.
EM leonard.a.temme.civ@mail.mil
OI Bleiberg, Joseph/0000-0003-0867-5494
FU Congressionally Directed Medical Research Program TBI; PTSD Programs
[W81XWIT-08-2-0052 PTO75175]
FX This research was supported in part by the Congressionally Directed
Medical Research Program TBI, PTSD Programs Award Number
W81XWIT-08-2-0052 PTO75175: the effects of hypoxia on cognitive function
in aviators and complex system operators that have had a mild traumatic
brain injury.
NR 34
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U1 1
U2 1
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015,
SWITZERLAND
SN 1664-2295
J9 FRONT NEUROL
JI Front. Neurol.
PD SEP 21
PY 2016
VL 7
AR 149
DI 10.3389/fneur.2016.00149
PG 10
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA DW6HN
UT WOS:000383751200001
PM 27708611
ER
PT J
AU Sviatenko, LK
Gorb, L
Hill, FC
Leszczynska, D
Shukla, MK
Okovytyy, SI
Hovorun, D
Leszczynski, J
AF Sviatenko, Liudmyla K.
Gorb, Leonid
Hill, Frances C.
Leszczynska, Danuta
Shukla, Manoj K.
Okovytyy, Sergiy I.
Hovorun, Dmytro
Leszczynski, Jerzy
TI In Silico Alkaline Hydrolysis of
Octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine: Density Functional
Theory Investigation
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID CIS-2-BUTENE-1,4-DIAL COMPUTATIONAL APPROACH; MULTISTEP
CHEMICAL-REACTIONS; PLASTIC-BONDED EXPLOSIVES; CRYSTAL-STRUCTURE;
HEXAHYDRO-1,3,5-TRINITRO-1,3,5-TRIAZINE RDX; BASE HYDROLYSIS; HMX;
DEGRADATION; KINETICS; INSIGHTS
AB HMX (octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine), an energetic material used in military applications, may be released to the environment during manufacturing, transportation, storage, training, and disposal. A detailed investigation of a possible mechanism of alkaline hydrolysis, as one of the most promising methods for HMX remediation, was performed by computational study at PCM(Pauling)/M06-2X/6-311++G(d,p) level. Obtained results suggest that HMX hydrolysis at pH 10 represents a highly exothermic multistep process involving initial deprotonation and nitrite elimination, hydroxide attachment accompanied by cycle cleavage, and further decomposition of cycle-opened intermediate to the products caused by a series of C-N bond ruptures, hydroxide attachments, and proton transfers. Computationally predicted products of HMX hydrolysis such as nitrite, 4-nitro-2,4-diazabutanal, formaldehyde, nitrous oxide, formate, and ammonia correspond to experimentally observed species. Based on computed reaction pathways for HMX decomposition by alkaline hydrolysis, the kinetics of the entire process was modeled. Very low efficiency of this reaction at pH 10 was observed. Computations predict significant increases (orders of magnitude) of the hydrolysis rate for hydrolysis reactions undertaken at pH 11, 12, and 13.
C1 [Sviatenko, Liudmyla K.; Leszczynski, Jerzy] Jackson State Univ, Dept Chem, Interdisciplinary Ctr Nanotox, Jackson, MS 39217 USA.
[Leszczynska, Danuta] Jackson State Univ, Dept Civil & Environm Engn, Interdisciplinary Ctr Nanotox, Jackson, MS 39217 USA.
[Sviatenko, Liudmyla K.; Okovytyy, Sergiy I.] Oles Honchar Dnipropetrovsk Natl Univ, Dept Organ Chem, UA-49000 Dnepropetrovsk, Ukraine.
[Gorb, Leonid] HX5, Vicksburg, MS 39180 USA.
[Hill, Frances C.; Shukla, Manoj K.] US Army Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
[Hovorun, Dmytro] Natl Acad Sci Ukraine, Inst Mol Biol & Genet, 150 Zabolotny St, UA-03143 Kiev, Ukraine.
RP Leszczynski, J (reprint author), Jackson State Univ, Dept Chem, Interdisciplinary Ctr Nanotox, Jackson, MS 39217 USA.
EM jerzy@icnanotox.org
RI Okovytyy, Sergiy/F-9838-2010
OI Okovytyy, Sergiy/0000-0003-4367-1309
FU ERDC [W912HZ-13-P-0037]; National Science Foundation [OCI-1053575];
XSEDE [DMR110088]
FX We thank ERDC for financial support (Grant W912HZ-13-P-0037).
Computation time was provided by the Extreme Science and Engineering
Discovery Environment (XSEDE) by National Science Foundation Grant
OCI-1053575 and XSEDE Award DMR110088 and by the Mississippi Center for
Supercomputer Research.
NR 46
TC 0
Z9 0
U1 9
U2 9
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
EI 1520-5851
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD SEP 20
PY 2016
VL 50
IS 18
BP 10039
EP 10046
DI 10.1021/acs.est.5b06130
PG 8
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA DX0FT
UT WOS:000384037900029
PM 27523798
ER
PT J
AU Memisevic, V
Kumar, K
Zavaljevski, N
DeShazer, D
Wallqvist, A
Reifman, J
AF Memisevic, Vesna
Kumar, Kamal
Zavaljevski, Nela
DeShazer, David
Wallqvist, Anders
Reifman, Jaques
TI DBSecSys 2.0: a database of Burkholderia mallei and Burkholderia
pseudomallei secretion systems
SO BMC BIOINFORMATICS
LA English
DT Article
DE Bacterial secretion system; Virulence factors; Pathogenic mechanisms of
action; Host-pathogen interactions; Burkholderia mallei; Burkholderia
pseudomallei
ID VI SECRETION; INTRACELLULAR SURVIVAL; PROTEIN INTERACTIONS; ANALYSIS
RESOURCE; VIRULENCE; GENOME; GENE; WEB; BROWSER; UPDATE
AB Background: Burkholderia mallei and B. pseudomallei are the causative agents of glanders and melioidosis, respectively, diseases with high morbidity and mortality rates. B. mallei and B. pseudomallei are closely related genetically; B. mallei evolved from an ancestral strain of B. pseudomallei by genome reduction and adaptation to an obligate intracellular lifestyle. Although these two bacteria cause different diseases, they share multiple virulence factors, including bacterial secretion systems, which represent key components of bacterial pathogenicity. Despite recent progress, the secretion system proteins for B. mallei and B. pseudomallei, their pathogenic mechanisms of action, and host factors are not well characterized.
Results: We previously developed a manually curated database, DBSecSys, of bacterial secretion system proteins for B. mallei. Here, we report an expansion of the database with corresponding information about B. pseudomallei. DBSecSys 2.0 contains comprehensive literature-based and computationally derived information about B. mallei ATCC 23344 and literature-based and computationally derived information about B. pseudomallei K96243. The database contains updated information for 163 B. mallei proteins from the previous database and 61 additional B. mallei proteins, and new information for 281 B. pseudomallei proteins associated with 5 secretion systems, their 1,633 human- and murine-interacting targets, and 2,400 host-B. mallei interactions and 2,286 host-B. pseudomallei interactions. The database also includes information about 13 pathogenic mechanisms of action for B. mallei and B. pseudomallei secretion system proteins inferred from the available literature or computationally. Additionally, DBSecSys 2.0 provides details about 82 virulence attenuation experiments for 52 B. mallei secretion system proteins and 98 virulence attenuation experiments for 61 B. pseudomallei secretion system proteins. We updated the Web interface and data access layer to speed-up users' search of detailed information for orthologous proteins related to secretion systems of the two pathogens.
Conclusions: The updates of DBSecSys 2.0 provide unique capabilities to access comprehensive information about secretion systems of B. mallei and B. pseudomallei. They enable studies and comparisons of corresponding proteins of these two closely related pathogens and their host-interacting partners. The database is available at http://dbsecsys.bhsai.org.
C1 [Memisevic, Vesna; Kumar, Kamal; Zavaljevski, Nela; Wallqvist, Anders; Reifman, Jaques] US Army, Dept Def Biotechnol High Performance Comp, Telemed & Adv Technol Res Ctr, Software Applicat Inst,Med Res & Mat Command, Ft Detrick, MD 21702 USA.
[DeShazer, David] US Army, Med Res Inst Infect Dis, Bacteriol Div, Ft Detrick, MD 21702 USA.
RP Reifman, J (reprint author), US Army, Dept Def Biotechnol High Performance Comp, Telemed & Adv Technol Res Ctr, Software Applicat Inst,Med Res & Mat Command, Ft Detrick, MD 21702 USA.
EM jaques.reifman.civ@mail.mil
FU Defense Threat Reduction Agency [CBS.MEDBIO.02.10.BH.021]; U.S. Medical
Research and Materiel Command, U.S. Army's Network Science Initiative
FX This work was supported by the Defense Threat Reduction Agency (project
CBS.MEDBIO.02.10.BH.021) and by the U.S. Medical Research and Materiel
Command (Ft. Detrick, MD) as part of the U.S. Army's Network Science
Initiative.
NR 38
TC 0
Z9 0
U1 5
U2 5
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2105
J9 BMC BIOINFORMATICS
JI BMC Bioinformatics
PD SEP 20
PY 2016
VL 17
AR 387
DI 10.1186/s12859-016-1242-z
PG 7
WC Biochemical Research Methods; Biotechnology & Applied Microbiology;
Mathematical & Computational Biology
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
Mathematical & Computational Biology
GA DW1LK
UT WOS:000383404500003
PM 27650316
ER
PT J
AU Plochl, M
Gaston, J
Mermagen, T
Konig, P
Hairston, WD
AF Ploechl, Michael
Gaston, Jeremy
Mermagen, Tim
Koenig, Peter
Hairston, W. David
TI Oscillatory activity in auditory cortex reflects the perceptual level of
audio-tactile integration
SO SCIENTIFIC REPORTS
LA English
DT Article
ID CROSS-MODAL BIAS; SENSORY AUGMENTATION; ASSOCIATION CORTEX;
EVOKED-RESPONSES; LOCALIZATION; DYNAMICS; BRAIN; SPACE; SOUND; TOUCH
AB Cross-modal interactions between sensory channels have been shown to depend on both the spatial disparity and the perceptual similarity between the presented stimuli. Here we investigate the behavioral and neural integration of auditory and tactile stimulus pairs at different levels of spatial disparity. Additionally, we modulated the amplitudes of both stimuli in either a coherent or non-coherent manner. We found that both auditory and tactile localization performance was biased towards the stimulus in the respective other modality. This bias linearly increases with stimulus disparity and is more pronounced for coherently modulated stimulus pairs. Analyses of electroencephalographic (EEG) activity at temporal-cortical sources revealed enhanced event-related potentials (ERPs) as well as decreased alpha and beta power during bimodal as compared to unimodal stimulation. However, while the observed ERP differences are similar for all stimulus combinations, the extent of oscillatory desynchronization varies with stimulus disparity. Moreover, when both stimuli were subjectively perceived as originating from the same direction, the reduction in alpha and beta power was significantly stronger. These observations suggest that in the EEG the level of perceptual integration is mainly reflected by changes in ongoing oscillatory activity.
C1 [Ploechl, Michael; Koenig, Peter] Univ Osnabruck, Inst Cognit Sci, Albrechtstr 28, D-49069 Osnabruck, Germany.
[Gaston, Jeremy; Mermagen, Tim; Hairston, W. David] Army Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD USA.
[Koenig, Peter] Univ Med Ctr Hamburg Eppendorf, Dept Neurophysiol & Pathophysiol, Martinistr 52, D-20246 Hamburg, Germany.
RP Plochl, M (reprint author), Univ Osnabruck, Inst Cognit Sci, Albrechtstr 28, D-49069 Osnabruck, Germany.
EM mploechl@uni-osnabrueck.de
FU Cognition and Neuroergonomics/Collaborative Technology Alliance
[W911NF-10-2-0022]
FX This work was supported by the Cognition and
Neuroergonomics/Collaborative Technology Alliance grant
#W911NF-10-2-0022.
NR 48
TC 0
Z9 0
U1 4
U2 4
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD SEP 20
PY 2016
VL 6
AR 33693
DI 10.1038/srep33693
PG 10
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA DW3QP
UT WOS:000383557800001
PM 27647158
ER
PT J
AU Baril, N
Brown, A
Maloney, P
Tidrow, M
Lubyshev, D
Qui, YM
Fastenau, JM
Liu, AWK
Bandara, S
AF Baril, Neil
Brown, Alexander
Maloney, Patrick
Tidrow, Meimei
Lubyshev, Dmitri
Qui, Yueming
Fastenau, Joel M.
Liu, Amy W. K.
Bandara, Sumith
TI Bulk InAsxSb1-x nBn photodetectors with greater than 5 mu m cutoff on
GaSb
SO APPLIED PHYSICS LETTERS
LA English
DT Article
AB Mid-wavelength infrared nBn photodetectors based on bulk InAsxSb1-x absorbers with a greater than 5 mu m cutoff grown on GaSb substrates are demonstrated. The extended cutoff was achieved by increasing the lattice constant of the substrate from 6.09 to 6.13 angstrom using a 1.5 mu m thick AlSb buffer layer to enable the growth of bulk InAs0.81Sb0.19 absorber material. Transitioning the lattice to 6.13 angstrom also enables the use of a simple binary AlSb layer as a unipolar barrier to block majority carrier electrons and reduce dark current noise. Individual test devices with 4 mu m thick absorbers displayed 150 K dark current density, cutoff wavelength, and quantum efficiency of 3x10(-5) A/cm(2), 5.31 mu m, and 44% at 3.4 mu m, respectively. The instantaneous dark current activation energy at a given bias and temperature is determined via Arrhenius analysis from the Dark current vs. temperature and bias data, and a discussion of valence band alignment between the InAsxSb1-x absorber and AlSb barrier layers is presented.
C1 [Baril, Neil; Brown, Alexander; Maloney, Patrick; Tidrow, Meimei; Bandara, Sumith] US Army RDECOM CERDEC NVESD, Ft Belvoir, VA 22060 USA.
[Lubyshev, Dmitri; Qui, Yueming; Fastenau, Joel M.; Liu, Amy W. K.] IQE Inc, Bethlehem, PA 18015 USA.
RP Baril, N (reprint author), US Army RDECOM CERDEC NVESD, Ft Belvoir, VA 22060 USA.
NR 19
TC 0
Z9 0
U1 12
U2 12
PU AMER INST PHYSICS
PI MELVILLE
PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA
SN 0003-6951
EI 1077-3118
J9 APPL PHYS LETT
JI Appl. Phys. Lett.
PD SEP 19
PY 2016
VL 109
IS 12
AR 122104
DI 10.1063/1.4963069
PG 4
WC Physics, Applied
SC Physics
GA DX7HX
UT WOS:000384558700026
ER
PT J
AU Crowell, TA
Fletcher, JLK
Sereti, I
Pinyakorn, S
Dewar, R
Krebs, SJ
Chomchey, N
Rerknimitr, R
Schuetz, A
Michael, NL
Phanuphak, N
Chomont, N
Ananworanich, J
AF Crowell, Trevor A.
Fletcher, James L. K.
Sereti, Irini
Pinyakorn, Suteeraporn
Dewar, Robin
Krebs, Shelly J.
Chomchey, Nitiya
Rerknimitr, Rungsun
Schuetz, Alexandra
Michael, Nelson L.
Phanuphak, Nittaya
Chomont, Nicolas
Ananworanich, Jintanat
CA RV254 SEAR010 Study Grp
TI Initiation of antiretroviral therapy before detection of colonic
infiltration by HIV reduces viral reservoirs, inflammation and immune
activation
SO JOURNAL OF THE INTERNATIONAL AIDS SOCIETY
LA English
DT Article
DE HIV; inflammation; CD4 lymphocyte count; highly active antiretroviral
therapy; virus latency; infectious disease reservoirs
ID VIRUS TYPE-1 INFECTION; CD4(+) T-CELLS; GUT EPITHELIAL BARRIER;
IMMUNODEFICIENCY-VIRUS; LYMPHOID-TISSUE; GASTROINTESTINAL-TRACT;
POSITIVE PATIENTS; SIV INFECTION; PERSISTENCE; MUCOSA
AB Introduction: Colonic infiltration by HIV occurs soon after infection, establishing a persistent viral reservoir and a barrier to cure. We investigated virologic and immunologic correlates of detectable colonic HIV RNA during acute HIV infection (AHI) and their response to antiretroviral treatment (ART).
Methods: From 49,458 samples screened for HIV, 74 participants were enrolled during AHI and 41 consented to optional sigmoidoscopy, HIV RNA was categorized as detectable (>= 50 copies/mg) or undetectable in homogenized colon biopsy specimens. Biomarkers and HIV burden in blood, colon and cerebrospinal fluid were compared between groups and after 24 weeks of ART.
Results: Colonic HIV RNA was detectable in 31 participants (76%) and was associated with longer duration since HIV exposure (median 16 vs. 11 days, p = 0.02), higher median plasma levels of cytokines and inflammatory markers (CXCL10 476 vs. 148 pg/mL, p = 0.02; TNF-RII 1036 vs. 649 pg/mL, p < 0.01; neopterin 2405 vs. 1368 pg/mL, p = 0.01) and higher levels of CD8 + T cell activation in the blood (human leukocyte antigen - antigen D related (HLA-DR)/CD38 expression 14.4% vs. 7.6%, p < 0.01) and colon (8.9% vs. 4.5%, p = 0.01). After 24 weeks of ART, participants with baseline detectable colonic HIV RNA demonstrated persistent elevations in total HIV DNA in colonic mucosal mononuclear cells (CMMCs) (median 61 vs. 0 copies/10(6) CMMCs, p = 0.03) and a trend towards higher total HIV DNA in peripheral blood mononuclear cells (PBMC) (41 vs. 1.5 copies/10(6) PBMCs, p = 0.06). There were no persistent differences in immune activation and inflammation.
Conclusions: The presence of detectable colonic HIV RNA at the time of ART initiation during AHI is associated with higher levels of proviral DNA after 24 weeks of treatment. Seeding of HIV in the gut may have long-lasting effects on the size of persistent viral reservoirs and may represent an important therapeutic target in eradication strategies.
C1 [Crowell, Trevor A.; Pinyakorn, Suteeraporn; Krebs, Shelly J.; Michael, Nelson L.; Ananworanich, Jintanat] Walter Reed Army Inst Res, US Mil HIV Res Program, 6720A Rockledge Dr,Suite 400, Bethesda, MD 20817 USA.
[Crowell, Trevor A.; Pinyakorn, Suteeraporn; Krebs, Shelly J.; Schuetz, Alexandra; Ananworanich, Jintanat] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA.
[Fletcher, James L. K.; Chomchey, Nitiya; Phanuphak, Nittaya; Ananworanich, Jintanat] Thai Red Cross AIDS Res Ctr, SEARCH, Bangkok, Thailand.
[Sereti, Irini] NIAID, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA.
[Dewar, Robin] Natl Canc Inst Frederick, Virus Isolat & Serol Lab, Frederick, MD USA.
[Rerknimitr, Rungsun] Chulalongkorn Univ, Fac Med, Dept Med, Bangkok, Thailand.
[Schuetz, Alexandra] Armed Forces Res Inst Med Sci United States Compo, Dept Retrovirol, Bangkok, Thailand.
[Chomont, Nicolas] Univ Montreal, Fac Med, Dept Microbiol Infectiol & Immunol, Montreal, PQ, Canada.
[Chomont, Nicolas] CHUM, Ctr Rech, Montreal, PQ, Canada.
RP Crowell, TA (reprint author), Walter Reed Army Inst Res, US Mil HIV Res Program, 6720A Rockledge Dr,Suite 400, Bethesda, MD 20817 USA.
EM tcrowell@hivresearch.org
FU Henry M Jackson Foundation for Advancement of Military Medicine, Inc.
[W81XWH-07-2-0067, W81XWH-11-2-0174]; US Department of the Army; Thai
Red Cross AIDS Research Center; Intramural Research Program of the
National Institute of Allergy and Infectious Diseases (National
Institutes of Health); Delaney AIDS Research Enterprise to find a cure
(DARE) [1U19AI096109]; National Cancer Institute, National Institutes of
Health [HHSN261200800001E]; Thai Government Pharmaceutical Organization;
Gilead; Merck and Pfizer
FX We thank our study participants and staff from the Thai Red Cross AIDS
Research Centre, Chulalongkorn University and AFRIMS for their valuable
contributions to this study. We are grateful to the Thai Government
Pharmaceutical Organization, ViiV Healthcare, Gilead and Merck for
providing the antiretrovirals for this study. The RV254/SEARCH 010 Study
Group includes from SEARCH/TRCARC/HIV-NAT: Nipat Teeratakulpisarn, Donn
Colby, Duanghathai Sutthichom, Somprartthana Rattanamanee, Peeriya
Prueksakaew, Sasiwimol Ubolyam, Pacharin Eamyoung, Suwanna Puttamaswin,
Somporn Tipsuk and Putthachard Karnsomlap; from Chulalongkorn
University: Wiriyaporn Ridtitid; from AFRIMS: Robert J O'Connell,
Siriwat Akapirat, Yuwadee Phuang-Ngern, Suchada Sukhumvittaya, Chayada
Sajjaweerawan, Surat Jongrakthaitae, Putita Saetun, Nipattra
Tragonlugsana, Bessara Nuntapinit, Rapee Trichavaroj, Nantana Tantibul
and Hathairat Savadsuk; from the US Military HIV Research Program:
Merlin Robb, Michael Eller, Silvia-Ratto Kim, Bonnie Slike and Sodsai
Tovanabutra; from VGTI Florida: Claire Vandergeeten, Wendy Bakeman,
Amanda McNulty and Remi Fromentin; from Monogram Biosciences: Laura
Napolitano, Molly Martell, Yolanda Lie, and the R&D and PDO groups. This
work was supported by cooperative agreements (W81XWH-07-2-0067,
W81XWH-11-2-0174) between the Henry M Jackson Foundation for the
Advancement of Military Medicine, Inc., and the US Department of the
Army and by an intramural grant from the Thai Red Cross AIDS Research
Center. The US Army Medical Research Acquisition Activity (820 Chandler
Street, Fort Detrick, MD 21702-5014, USA) is the awarding and
administering acquisition office for the cooperative agreement. This
research was supported in part by the Intramural Research Program of the
National Institute of Allergy and Infectious Diseases (National
Institutes of Health) and the Delaney AIDS Research Enterprise to find a
cure (DARE, 1U19AI096109). It has also been funded in part with federal
funds from the National Cancer Institute, National Institutes of Health,
under Contract No. HHSN261200800001E. Antiretroviral therapy was
supported by the Thai Government Pharmaceutical Organization, Gilead,
Merck and Pfizer.
NR 62
TC 0
Z9 0
U1 2
U2 2
PU INT AIDS SOCIETY
PI GENEVA
PA AVENUE DE FRANCE 23, GENEVA, 1202, SWITZERLAND
SN 1758-2652
J9 J INT AIDS SOC
JI J. Int. AIDS Soc.
PD SEP 15
PY 2016
VL 19
AR 21163
DI 10.7448/IAS.19.1.21163
PG 9
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA ED5FC
UT WOS:000388876000001
PM 27637172
ER
PT J
AU Darling, KA
Rajagopalan, M
Komarasamy, M
Bhatia, MA
Hornbuckle, BC
Mishra, RS
Solanki, KN
AF Darling, K. A.
Rajagopalan, M.
Komarasamy, M.
Bhatia, M. A.
Hornbuckle, B. C.
Mishra, R. S.
Solanki, K. N.
TI Extreme creep resistance in a microstructurally stable nanocrystalline
alloy
SO NATURE
LA English
DT Article
ID CU-TA ALLOYS; MECHANICAL-PROPERTIES; MOLECULAR-DYNAMICS; SUPERALLOYS;
TEMPERATURE; ALGORITHMS; METALS; DESIGN; SYSTEM
AB Nanocrystalline metals, with a mean grain size of less than 100 nanometres, have greater room-temperature strength than their coarse-grained equivalents, in part owing to a large reduction in grain size(1). However, this high strength generally comes with substantial losses in other mechanical properties, such as creep resistance, which limits their practical utility; for example, creep rates in nanocrystalline copper are about four orders of magnitude higher than those in typical coarse-grained copper(2,3). The degradation of creep resistance in nanocrystalline materials is in part due to an increase in the volume fraction of grain boundaries, which lack long-range crystalline order and lead to processes such as diffusional creep, sliding and rotation(3). Here we show that nanocrystalline copper-tantalum alloys possess an unprecedented combination of properties: high strength combined with extremely high-temperature creep resistance, while maintaining mechanical and thermal stability. Precursory work on this family of immiscible alloys has previously highlighted their thermo-mechanical stability and strength(4,5), which has motivated their study under more extreme conditions, such as creep. We find a steady-state creep rate of less than 10(-6) per second-six to eight orders of magnitude lower than most nanocrystalline metals-at various temperatures between 0.5 and 0.64 times the melting temperature of the matrix (1,356 kelvin) under an applied stress ranging from 0.85 per cent to 1.2 per cent of the shear modulus. The unusual combination of properties in our nanocrystalline alloy is achieved via a processing route that creates distinct nanoclusters of atoms that pin grain boundaries within the alloy. This pinning improves the kinetic stability of the grains by increasing the energy barrier for grain-boundary sliding and rotation and by inhibiting grain coarsening, under extremely long-term creep conditions. Our processing approach should enable the development of microstructurally stable structural alloys with high strength and creep resistance for various high-temperature applications, including in the aerospace, naval, civilian infrastructure and energy sectors.
C1 [Darling, K. A.; Hornbuckle, B. C.] Army Res Lab, Aberdeen Proving Ground, MD 21005 USA.
[Rajagopalan, M.; Bhatia, M. A.; Solanki, K. N.] Arizona State Univ, Sch Engn Matter Transport & Energy, Tempe, AZ 85281 USA.
[Komarasamy, M.; Mishra, R. S.] Univ North Texas, Dept Mat Sci & Engn, Denton, TX 76203 USA.
RP Solanki, KN (reprint author), Arizona State Univ, Sch Engn Matter Transport & Energy, Tempe, AZ 85281 USA.
EM kiran.solanki@asu.edu
RI Mishra, Rajiv/A-7985-2009
OI Mishra, Rajiv/0000-0002-1699-0614
FU US Army Research Laboratory [W911NF-15-2-0038]
FX M.R., and K.N.S. acknowledge the use of facilities within the LeRoy
Eyring Center for Solid State Science at Arizona State University. This
work was supported by US Army Research Laboratory under contract
W911NF-15-2-0038. K.A.D. acknowledges A. J. Roberts and T. Luckenbaugh
for synthesis of the Cu-Ta powder.
NR 35
TC 3
Z9 3
U1 38
U2 38
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0028-0836
EI 1476-4687
J9 NATURE
JI Nature
PD SEP 15
PY 2016
VL 537
IS 7620
BP 378
EP +
DI 10.1038/nature19313
PG 14
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA DV7EC
UT WOS:000383098000049
PM 27629642
ER
PT J
AU Amarasinghe, PM
Kim, JS
Chen, H
Trivedi, S
Qadri, SB
Soos, J
Diestler, M
Zhang, DJ
Gupta, N
Jensen, JL
Jensen, J
AF Amarasinghe, Priyanthi M.
Kim, Joo-Soo
Chen, Henry
Trivedi, Sudhir
Qadri, Syed B.
Soos, Jolanta
Diestler, Mark
Zhang, Dajie
Gupta, Neelam
Jensen, Janet L.
Jensen, James
TI Growth of high quality mercurous halide single crystals by physical
vapor transport method for AOM and radiation detection applications
SO JOURNAL OF CRYSTAL GROWTH
LA English
DT Article
DE High resolution X-ray diffraction; X-ray topography; Growth from vapor;
Single crystal growth; Halides; Acousto-optic materials
ID SPECTROPOLARIMETRIC IMAGER; DISTANCES; HG2CL2; HG2BR2
AB Single crystals of mercurous halide were grown by physical vapor transport method (PVT). The orientation and the crystalline quality of the grown crystals were determined using high resolution x-ray diffraction (HRXRD) technique. The full width at half maximum (FWHM) of the grown mercurous bromide crystals was measured to be 0.13 degrees for (004) reflection, which is the best that has been achieved so far for PVT grown mercurous halide single crystals. The extended defects of the crystals were also analyzed using high resolution x-ray diffraction topography. Preliminary studies were carried out to evaluate the performance of the crystals on acousto-optic modulator (AOM) and gamma-ray detector applications. The results indicate the grown mercurous halide crystals are excellent materials for acousto-optic modulator device fabrication. The diffraction efficiencies of the fabricated AOM device with 1152 and 1523 nm wavelength lasers polarizing parallel to the acoustic wave were found to be 35% and 28%, respectively. The results also indicate the grown crystals are a promising material for gamma-ray detector application with a very high energy resolution of 1.86% FVVHM. (C) 2016 Elsevier B.V. All rights reserved.
C1 [Amarasinghe, Priyanthi M.; Kim, Joo-Soo; Chen, Henry; Trivedi, Sudhir; Soos, Jolanta; Diestler, Mark; Zhang, Dajie] Brimrose Technol Corp, Sparks, MD 21152 USA.
[Qadri, Syed B.] US Naval Res Lab, Washington, DC USA.
[Gupta, Neelam] US Army, Res Lab, Adelphi, MD USA.
[Jensen, Janet L.; Jensen, James] US Army, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD USA.
RP Amarasinghe, PM (reprint author), Brimrose Technol Corp, Sparks, MD 21152 USA.
EM pamarsi@brimrose.com
FU US Army Edgewood Chemical Biological Center [W911SR-14-C-0065]; US Army
Research Laboratory [W911QX-06-C-0074, W911QX-06-C-0074-P0006]
FX The authors would like to thank Dave Mayers, Paul Deng, Helen He and
Julie Chen for their support on sample preparation. This research has
been supported by the US Army Edgewood Chemical Biological Center,
Contract number W911SR-14-C-0065 and US Army Research Laboratory,
Contract numbers W911QX-06-C-0074 and W911QX-06-C-0074-P0006.
NR 19
TC 0
Z9 0
U1 4
U2 4
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0022-0248
EI 1873-5002
J9 J CRYST GROWTH
JI J. Cryst. Growth
PD SEP 15
PY 2016
VL 450
BP 96
EP 102
DI 10.1016/j.jcrysgro.2016.06.025
PG 7
WC Crystallography; Materials Science, Multidisciplinary; Physics, Applied
SC Crystallography; Materials Science; Physics
GA DU5MX
UT WOS:000382256900016
ER
PT J
AU Meredith, CS
Lloyd, JT
Sano, T
AF Meredith, Christopher S.
Lloyd, Jeffrey T.
Sano, Tomoko
TI The quasi-static and dynamic response of fine-grained Mg alloy AMX602:
An experimental and computational study
SO MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES
MICROSTRUCTURE AND PROCESSING
LA English
DT Article
DE Magnesium alloy AMX602; Spinning water atomization process (SWAP); Grain
refinement; Anisotropy; Twinning; Crystal plasticity
ID WATER-ATOMIZATION PROCESS; SOLIDIFICATION POWDER-METALLURGY; MAGNESIUM
ALLOY; CRYSTALLOGRAPHIC TEXTURE; MECHANICAL-PROPERTIES; PLASTIC
ANISOTROPY; HOT EXTRUSION; AZ31B SHEET; DEFORMATION; BEHAVIOR
AB A high strength magnesium alloy, AMX602 (Mg-6%Al-0.5%Mn-2%Ca), was manufactured by the spinning water atomization process (SWAP) and extruded into bar and plate geometries. Microstructural analysis using electron backscatter diffraction revealed that the processing produces an alloy with grains between 0.5 and 5 mu m, with comparatively weak texture for Mg. The plate and bar had different textures-the former had a conventional hexagonal-close-packed (HCP) rolling texture and the latter a HCP extrusion texture. Quasi-static and dynamic compression experiments were performed to probe the material's mechanical behavior in the three processing directions. The experiments on each geometry revealed different anisotropic properties induced by a change in the active deformation mechanisms. The anisotropy was more pronounced at dynamic strain rates than quasi-static. A reduced-order crystal plasticity model that demarcates twinning, basal slip, and non-basal slip mechanisms was fit to the experimental data from the plate and bar. The model was consistent with experimental data and revealed that in the plate twinning dominated yielding in the extrusion and transverse directions, but slip dominated the normal direction. Yielding in the bar was dominated by twinning in the extrusion direction, but both slip and twinning were significant in the other two directions. The model showed the different anisotropic responses were due to the different textures produced during the processing of each geometry. Lastly, our data provided the basis for considering twinning to be rate insensitive in the model, which we confirm to be valid to at least 5000 s(-1). Published by Elsevier B.V.
C1 [Meredith, Christopher S.; Lloyd, Jeffrey T.] Army Res Lab, Impact Phys Branch, Aberdeen Proving Ground, MD USA.
[Sano, Tomoko] Army Res Lab, Lightweight & Specialty Met Branch, Aberdeen Proving Ground, MD USA.
RP Meredith, CS (reprint author), Army Res Lab, Impact Phys Branch, Aberdeen Proving Ground, MD USA.
EM christopher.s.meredith3.civ@mail.mil
OI Meredith, Christopher/0000-0003-1368-8003
NR 42
TC 0
Z9 0
U1 10
U2 10
PU ELSEVIER SCIENCE SA
PI LAUSANNE
PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND
SN 0921-5093
EI 1873-4936
J9 MAT SCI ENG A-STRUCT
JI Mater. Sci. Eng. A-Struct. Mater. Prop. Microstruct. Process.
PD SEP 15
PY 2016
VL 673
BP 73
EP 82
DI 10.1016/j.msea.2016.07.035
PG 10
WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary;
Metallurgy & Metallurgical Engineering
SC Science & Technology - Other Topics; Materials Science; Metallurgy &
Metallurgical Engineering
GA DU7QP
UT WOS:000382410000009
ER
PT J
AU Bryan, CJ
Rudd, MD
Peterson, AL
Young-McCaughan, S
Wertenberger, EG
AF Bryan, Craig J.
Rudd, M. David
Peterson, Alan L.
Young-McCaughan, Stacey
Wertenberger, Evelyn G.
TI The ebb and flow of the wish to live and the wish to die among suicidal
military personnel
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Suicide; Military; Brief cognitive behavioral therapy; Suicidal
ambivalence
ID RANDOMIZED CONTROLLED-TRIAL; BEHAVIORAL THERAPY BCBT; FOLLOW-UP; DEATH
AB Background: The relative balance between the wish to live and the wish to die (i.e., suicidal ambivalence) is a robust predictor of suicidal behavior and may be a mechanism underlying the effectiveness of treatments that reduce suicidal behaviors. To date, however, few studies have explored possible mechanisms of action in these treatments.
Method: Active duty Soldiers (N=152) with a recent suicide attempt and/or active suicide ideation were randomized to receive brief cognitive behavioral therapy (BCBT) or treatment as usual (TAU). The Suicide Attempt Self-Injury Inventory (Linehan et al., 2006a) was used to assess the incidence of suicide attempts during the 2-year follow-up. The wish to live and the wish to die were assessed with items 1 and 2, respectively, of the Beck Scale for Suicide Ideation (Beck and Steer, 1991).
Results: Across both treatments, the wish to live was significantly weaker among patients who attempted suicide but the wish to die was stronger only among patients who attempted suicide in TAU. Among nonattempters, the wish to die stabilized the wish to live, but among attempters the wish to live and the wish to die were not associated with each other. In BCBT the wish to live destabilized the wish to die among nonattempters. Limitations: Self-report methodology, predominantly male sample.
Conclusions: The emergence of suicidal behavior is driven primarily by the absence of the wish to live. BCBT is associated with a unique coupling of an ambivalent wish to live and wish to die, which may suggest an underlying mechanism of action. (C) 2016 Elsevier B.V. All rights reserved.
C1 [Bryan, Craig J.] Univ Utah, Natl Ctr Vet Studies, 260 S Cent Campus Dr,Room 205, Salt Lake City, UT 84112 USA.
[Rudd, M. David] Univ Memphis, Natl Ctr Vet Studies, Memphis, TN 38152 USA.
[Peterson, Alan L.] Univ Texas Hlth Sci Ctr San Antonio, South Texas Vet Hlth Care Syst, San Antonio, TX 78229 USA.
[Young-McCaughan, Stacey] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA.
[Wertenberger, Evelyn G.] US Army, MEDDAC, Ft Carson, CO USA.
RP Bryan, CJ (reprint author), Univ Utah, Natl Ctr Vet Studies, 260 S Cent Campus Dr,Room 205, Salt Lake City, UT 84112 USA.
EM craig.bryan@utah.edu
OI Bryan, Craig/0000-0002-9714-0733
FU Department of Defense [W81XWH-09-1-0569]
FX This project was supported in part through research funding by the
Department of Defense award #W81XWH-09-1-0569 (M. david Rudd, Principal
Investigator). The views expressed in this article are solely those of
the authors and do not represent the official position or policy of the
U.S. Army, the Department of Defense, or the United States Government.
NR 23
TC 2
Z9 2
U1 2
U2 6
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD SEP 15
PY 2016
VL 202
BP 58
EP 66
DI 10.1016/j.jad.2016.05.049
PG 9
WC Clinical Neurology; Psychiatry
SC Neurosciences & Neurology; Psychiatry
GA DS2EH
UT WOS:000380555400009
PM 27253218
ER
PT J
AU Ladner, JT
Wiley, MR
Beitzel, B
Auguste, AJ
Dupuis, AP
Lindquist, ME
Sibley, SD
Kota, KP
Fetterer, D
Eastwood, G
Kimmel, D
Prieto, K
Guzman, H
Aliota, MT
Reyes, D
Brueggemann, EE
John, LS
Hyeroba, D
Lauck, M
Friedrich, TC
O'Connor, DH
Gestole, MC
Cazares, LH
Popov, VL
Castro-Llanos, F
Kochel, TJ
Kenny, T
White, B
Ward, MD
Loaiza, JR
Goldberg, TL
Weaver, SC
Kramer, LD
Tesh, RB
Palacios, G
AF Ladner, Jason T.
Wiley, Michael R.
Beitzel, Brett
Auguste, Albert J.
Dupuis, Alan P., II
Lindquist, Michael E.
Sibley, Samuel D.
Kota, Krishna P.
Fetterer, David
Eastwood, Gillian
Kimmel, David
Prieto, Karla
Guzman, Hilda
Aliota, Matthew T.
Reyes, Daniel
Brueggemann, Ernst E.
John, Lena St.
Hyeroba, David
Lauck, Michael
Friedrich, Thomas C.
O'Connor, David H.
Gestole, Marie C.
Cazares, Lisa H.
Popov, Vsevolod L.
Castro-Llanos, Fanny
Kochel, Tadeusz J.
Kenny, Tara
White, Bailey
Ward, Michael D.
Loaiza, Jose R.
Goldberg, Tony L.
Weaver, Scott C.
Kramer, Laura D.
Tesh, Robert B.
Palacios, Gustavo
TI A Multicomponent Animal Virus Isolated from Mosquitoes
SO CELL HOST & MICROBE
LA English
DT Article
ID RNA VIRUSES; MAXIMUM-LIKELIHOOD; GENOME SEGMENTS; FLAVIVIRUS;
TRANSMISSION; EXPRESSION; PREDICTION; TRINIDAD; REGIONS; VECTOR
AB RNA viruses exhibit a variety of genome organization strategies, including multicomponent genomes in which each segment is packaged separately. Although multicomponent genomes are common among viruses infecting plants and fungi, their prevalence among those infecting animals remains unclear. We characterize a multicomponent RNA virus isolated from mosquitoes, designated Guaico Culex virus (GCXV). GCXV belongs to a diverse clade of segmented viruses (Jingmenvirus) related to the prototypically unsegmented Flaviviridae. The GCXV genome comprises five segments, each of which appears to be separately packaged. The smallest segment is not required for replication, and its presence is variable in natural infections. We also describe a variant of Jingmen tick virus, another Jingmenvirus, sequenced from a Ugandan red colobus monkey, thus expanding the host range of this segmented and likely multicomponent virus group. Collectively, this study provides evidence for the existence of multicomponent animal viruses and their potential relevance for animal and human health.
C1 [Ladner, Jason T.; Wiley, Michael R.; Beitzel, Brett; Kimmel, David; Prieto, Karla; Reyes, Daniel; John, Lena St.; Gestole, Marie C.; White, Bailey; Palacios, Gustavo] US Army Med Res Inst Infect Dis, Ctr Genome Sci, Ft Detrick, MD 21702 USA.
[Auguste, Albert J.; Guzman, Hilda; Popov, Vsevolod L.; Weaver, Scott C.; Tesh, Robert B.] Univ Texas Med Branch, Inst Human Infect & Immun, Dept Pathol, Galveston, TX 77555 USA.
[Auguste, Albert J.; Guzman, Hilda; Popov, Vsevolod L.; Weaver, Scott C.; Tesh, Robert B.] Univ Texas Med Branch, Dept Microbiol & Immunol, Galveston, TX 77555 USA.
[Auguste, Albert J.; Guzman, Hilda; Popov, Vsevolod L.; Weaver, Scott C.; Tesh, Robert B.] Univ Texas Med Branch, Ctr Biodef & Emerging Infect Dis, Galveston, TX 77555 USA.
[Dupuis, Alan P., II; Eastwood, Gillian; Aliota, Matthew T.; Kramer, Laura D.] New York State Dept Hlth, Wadsworth Ctr, Arbovirus Lab, Albany, NY 12159 USA.
[Lindquist, Michael E.] US Army Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA.
[Kota, Krishna P.; Brueggemann, Ernst E.; Cazares, Lisa H.; Kenny, Tara; Ward, Michael D.] US Army Med Res Inst Infect Dis, Mol & Translat Sci Div, Ft Detrick, MD 21702 USA.
[Fetterer, David] US Army Med Res Inst Infect Dis, Res Support Div, Ft Detrick, MD 21702 USA.
[Sibley, Samuel D.; Friedrich, Thomas C.; Goldberg, Tony L.] Univ Wisconsin, Dept Pathobiol Sci, Madison, WI 53706 USA.
[Cazares, Lisa H.] Henry M Jackson Fdn, Bethesda, MD 20817 USA.
[Cazares, Lisa H.] DoD Biotechnol High Performance Comp Software App, Frederick, MD 21702 USA.
[Cazares, Lisa H.] US Army Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Ft Detrick, MD 21702 USA.
[Castro-Llanos, Fanny; Kochel, Tadeusz J.] US Naval Med Res Unit 6, Lima, Peru.
[Loaiza, Jose R.] Inst Invest Cient & Serv Alta Tecnol, Ctr Biodiversidad & Descubrimiento Drogas, Ciudad De Panama, Panama.
[Goldberg, Tony L.] Makerere Univ, Kampala, Uganda.
[Lauck, Michael; Friedrich, Thomas C.; O'Connor, David H.; Goldberg, Tony L.] Wisconsin Natl Primate Res Ctr, Madison, WI 53715 USA.
[Kramer, Laura D.] SUNY Albany, Sch Publ Hlth, One Univ Pl Rensselaer, East Greenbush, NY 12144 USA.
[Lauck, Michael] Univ Wisconsin, Sch Med & Publ Hlth, Dept Pathol & Lab Med, Madison, WI 53706 USA.
[Aliota, Matthew T.] Univ Wisconsin, Dept Pathobiol Sci, Madison, WI 53706 USA.
[Gestole, Marie C.] Natl Biodef Anal & Countermeasures Ctr, Ft Detrick, MD 21702 USA.
RP Ladner, JT; Palacios, G (reprint author), US Army Med Res Inst Infect Dis, Ctr Genome Sci, Ft Detrick, MD 21702 USA.
EM jason.t.ladner.ctr@mail.mil; gustavo.f.palacios.ctr@mail.mil
OI Palacios, Gustavo/0000-0001-5062-1938
FU Defense Threat Reduction Agency [1881290]; NIH
[HHSN272201000040I/HHSN27200004/D04]; James W. McLaughlin Endowment
fund; Smithsonian Tropical Research Institute-Environmental Protection
Agency [DW33-92296801-0]; Robert E. Shope fellowship
FX Work at U.S. Army Medical Research Institute of Infectious Diseases was
funded by the Defense Threat Reduction Agency, project 1881290. Work at
UTMB was supported by NIH contract HHSN272201000040I/HHSN27200004/D04 to
R.B.T. A.J.A. was supported by the James W. McLaughlin Endowment fund.
Mosquito collection in Panama was funded by Smithsonian Tropical
Research Institute-Environmental Protection Agency grant DW33-92296801-0
to Montira J. Pongsiri. Work in Panama was supported by a Robert E.
Shope fellowship awarded to G.E.
NR 42
TC 2
Z9 2
U1 11
U2 11
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 1931-3128
EI 1934-6069
J9 CELL HOST MICROBE
JI Cell Host Microbe
PD SEP 14
PY 2016
VL 20
IS 3
BP 357
EP 367
DI 10.1016/j.chom.2016.07.011
PG 11
WC Microbiology; Parasitology; Virology
SC Microbiology; Parasitology; Virology
GA DX1QW
UT WOS:000384143100012
PM 27569558
ER
PT J
AU Tovar, TM
Zhao, JJ
Nunn, WT
Barton, HF
Peterson, GW
Parsons, GN
Levan, MD
AF Tovar, Trenton M.
Zhao, Junjie
Nunn, William T.
Barton, Heather F.
Peterson, Gregory W.
Parsons, Gregory N.
LeVan, M. Douglas
TI Diffusion of CO2 in Large Crystals of Cu-BTC MOF
SO JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Article
ID METAL-ORGANIC FRAMEWORKS; SWING FREQUENCY-RESPONSE; ULTRAHIGH
SURFACE-AREA; MOLECULAR SIMULATION; ADSORPTION EQUILIBRIUM; CARBON;
SEPARATION; REDUCTION; PHOTOCATALYSIS; DYNAMICS
AB Carbon dioxide adsorption in metal organic frameworks has been widely studied for applications in carbon capture and sequestration. A critical component that has been largely overlooked is the measurement of diffusion rates. This paper describes a new reproducible procedure to synthesize millimeter-scale Cu-BTC single crystals using concentrated reactants and an acetic acid modulator. Microscopic images, X-ray diffraction patterns, Brunauer-Emmett-Teller surface areas, and thermogravimetric analysis results all confirm the high quality of these Cu-BTC single crystals. The large crystal size aids in the accurate measurement of micropore diffusion coefficients. Concentration-swing frequency response performed at varying gas-phase concentrations gives diffusion coefficients that show very little dependence on the loading up to pressures of 0.1 bar. The measured micropore diffusion coefficient for CO2 in Cu-BTC is X 10(-9) m(2)/s.
C1 [Tovar, Trenton M.; LeVan, M. Douglas] Vanderbilt Univ, Dept Chem & Biomol Engn, Nashville, TN 37235 USA.
[Zhao, Junjie; Nunn, William T.; Barton, Heather F.; Parsons, Gregory N.] North Carolina State Univ, Dept Chem & Biomol Engn, Raleigh, NC 27695 USA.
[Peterson, Gregory W.] US Army, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA.
RP Levan, MD (reprint author), Vanderbilt Univ, Dept Chem & Biomol Engn, Nashville, TN 37235 USA.; Parsons, GN (reprint author), North Carolina State Univ, Dept Chem & Biomol Engn, Raleigh, NC 27695 USA.
EM gnp@ncsu.edu; m.douglas.levan@vanderbilt.edu
RI Zhao, Junjie/B-8206-2016; Parsons, Gregory/O-9762-2014
OI Zhao, Junjie/0000-0001-6205-9671; Parsons, Gregory/0000-0002-0048-5859
FU ECBC [W911SR-07-C-0075, W911SR-13-0014]; Joint Science and Technology
Office (Army Research Office) [W911NF-13-1-0173]
FX The authors acknowledge funding from ECBC (Grants W911SR-07-C-0075 and
W911SR-13-0014) and the Joint Science and Technology Office (Army
Research Office Grant W911NF-13-1-0173). J.Z. acknowledges Roger Sommer,
Edward Sachet, and Prof. Jon-Paul Maria for the XRD measurement of
single crystals and appreciates the use of the thermogravimetric
analyzer in Prof. Saad Khan's group.
NR 35
TC 1
Z9 1
U1 134
U2 134
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0002-7863
J9 J AM CHEM SOC
JI J. Am. Chem. Soc.
PD SEP 14
PY 2016
VL 138
IS 36
BP 11449
EP 11452
DI 10.1021/jacs.6b05930
PG 4
WC Chemistry, Multidisciplinary
SC Chemistry
GA DW1NU
UT WOS:000383410700007
PM 27556899
ER
PT J
AU Borodin, O
Price, DL
Aoun, B
Gonzalez, MA
Hooper, JB
Kofu, M
Kohara, S
Yamamuro, O
Saboungi, ML
AF Borodin, Oleg
Price, David L.
Aoun, Bachir
Gonzalez, Miguel A.
Hooper, Justin B.
Kofu, Maiko
Kohara, Shinji
Yamamuro, Osamu
Saboungi, Marie-Louise
TI Effect of water on the structure of a prototype ionic liquid
SO PHYSICAL CHEMISTRY CHEMICAL PHYSICS
LA English
DT Article
ID MOLECULAR-DYNAMICS SIMULATIONS; POLARIZABLE FORCE-FIELD;
ROOM-TEMPERATURE; 1-BUTYL-3-METHYLIMIDAZOLIUM TETRAFLUOROBORATE;
AQUEOUS-SOLUTIONS; IMIDAZOLIUM CATION; ATOMISTIC INSIGHT; MIXTURES;
HEXAFLUOROPHOSPHATE; THERMODYNAMICS
AB The influence of water on the structure of a prototype ionic liquid (IL) 1-octyl-3-methylimidazolium tetrafluoroborate (C(8)mimBF(4)) is examined in the IL-rich regime using high-energy X-ray diffraction (HEXRD) and molecular dynamics (MD) simulations. A many-body polarizable force field APPLE&P was developed for C(8)mimBF(4)mimBF4-water mixture. It predicts structure factors of pure IL and IL-water mixture in excellent agreement with the HEXRD experiments. The MD results provide detailed insights into the structural changes from the partial structure factors, 2-D projections of the simulation box and 3-D distribution functions. Water partitioning with IL and its competition with BF4- for complexing the imidazolium rings was examined. The added water molecules occupy a diffuse coordination shell around the imidazolium ring but are not present around the alkyl tail. The strong coordination of the fluorine atoms of the BF4- anions to the imidazolium ring is not significantly changed by the addition of water. A complementary packing of water and imidazolium around BF4- was found. These results are consistent with the very small differences in the average structure between the pure IL and the mixture.
C1 [Borodin, Oleg] US Army Res Lab, Sensor & Electron Devices Directorate, Electrochem Branch, Adelphi, MD 20783 USA.
[Price, David L.] CEMHTI, 1d Ave Rech Sci, F-45071 Orleans 2, France.
[Aoun, Bachir] Argonne Natl Lab, Adv Photon Source, Argonne, IL 60439 USA.
[Gonzalez, Miguel A.] Inst Laue Langevin, 71 Ave Martyrs, F-38042 Grenoble 9, France.
[Hooper, Justin B.] Univ Utah, Dept Mat Sci & Engn, Salt Lake City, UT 84112 USA.
[Kofu, Maiko; Yamamuro, Osamu] Univ Tokyo, Inst Solid State Phys, 5-1-5 Kashiwanoha, Kashiwa, Chiba 2778581, Japan.
[Kohara, Shinji] Natl Inst Mat Sci, 1-1-1 Kouto, Sayo, Hyogo 6795148, Japan.
[Kohara, Shinji] JST, PRESTO, 4-1-8 Honcho, Kawaguchi, Saitama 3320012, Japan.
[Saboungi, Marie-Louise] Univ Orleans, Coll Sci & Tech, 4 Pl Jussieu, F-75252 Paris, France.
[Saboungi, Marie-Louise] Univ Paris 06, IMPMC, 4 Pl Jussieu, F-75252 Paris, France.
[Saboungi, Marie-Louise] BCMaterials, Parque Tecnol Vizcaya, Derio 48160, Spain.
RP Saboungi, ML (reprint author), Univ Orleans, Coll Sci & Tech, 4 Pl Jussieu, F-75252 Paris, France.; Saboungi, ML (reprint author), Univ Paris 06, IMPMC, 4 Pl Jussieu, F-75252 Paris, France.; Saboungi, ML (reprint author), BCMaterials, Parque Tecnol Vizcaya, Derio 48160, Spain.
EM ml.saboungi@gmail.com
RI Gonzalez, Miguel/R-8330-2016
OI Gonzalez, Miguel/0000-0002-3478-0215
FU Spanish Ministry of Economy and Competitiveness [MAT2013-48366-C2-1];
DOE Office of Science [DE-AC02-06CH11357]; Air Force Office of
Scientific Research, Department of the Air Force [FA9550-09-C-0110];
University of Utah
FX We thank Professor Luis Paulo Rebelo for helpful discussions of phase
diagrams. MLS acknowledges a JSPS fellowship and financial support from
Spanish Ministry of Economy and Competitiveness (Grant
MAT2013-48366-C2-1). DLP acknowledges a visiting appointment at J-PARC,
Tokai, Japan. We are grateful to Professor M. Arai and J-PARC staff for
their help and scientific discussions. The synchrotron X-ray experiments
were carried out with the approval of the Japan Synchrotron Radiation
Research Institute (JASRI) (Proposal nos. 2013A1295, 2013A1333 and
2014A1044). This research also used resources of the Advanced Photon
Source, a U.S. Department of Energy (DOE) Office of Science User
Facility operated for the DOE Office of Science by Argonne National
Laboratory under Contract No. DE-AC02-06CH11357. The force field
development was supported by Air Force Office of Scientific Research,
Department of the Air Force contract number FA9550-09-C-0110 to Wasatch
Molecular Inc. and University of Utah (PM Mike Berman).
NR 59
TC 3
Z9 3
U1 17
U2 17
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
ENGLAND
SN 1463-9076
EI 1463-9084
J9 PHYS CHEM CHEM PHYS
JI Phys. Chem. Chem. Phys.
PD SEP 14
PY 2016
VL 18
IS 34
BP 23474
EP 23481
DI 10.1039/c6cp02191c
PG 8
WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical
SC Chemistry; Physics
GA DU3JS
UT WOS:000382107200005
PM 27225393
ER
PT J
AU Konduru, K
Shurtleff, AC
Bradfute, SB
Nakamura, S
Bavari, S
Kaplan, G
AF Konduru, Krishnamurthy
Shurtleff, Amy C.
Bradfute, Steven B.
Nakamura, Siham
Bavari, Sina
Kaplan, Gerardo
TI Ebolavirus Glycoprotein Fc Fusion Protein Protects Guinea Pigs against
Lethal Challenge
SO PLOS ONE
LA English
DT Article
ID RESPIRATORY-TRACT IMMUNIZATION; VESICULAR STOMATITIS-VIRUS;
NONHUMAN-PRIMATES; HEMORRHAGIC-FEVER; FAMILY FILOVIRIDAE; VACCINE
CANDIDATE; PARTICLES PROTECT; IMMUNE-RESPONSES; INFECTION; ANTIBODY
AB Ebola virus (EBOV), a member of the Filoviridae that can cause severe hemorrhagic fever in humans and nonhuman primates, poses a significant threat to the public health. Currently, there are no licensed vaccines or therapeutics to prevent and treat EBOV infection. Several vaccines based on the EBOV glycoprotein (GP) are under development, including vectored, virus-like particles, and protein-based subunit vaccines. We previously demonstrated that a subunit vaccine containing the extracellular domain of the Ebola ebolavirus (EBOV) GP fused to the Fc fragment of human IgG1 (EBOVgp-Fc) protected mice against EBOV lethal challenge. Here, we show that the EBOVgp-Fc vaccine formulated with QS-21, alum, or polyinosinic-polycytidylic acid-poly-L-lysine carboxymethylcellulose (poly-ICLC) adjuvants induced strong humoral immune responses in guinea pigs. The vaccinated animals developed anti-GP total antibody titers of approximately 10(5)-10(6) and neutralizing antibody titers of approximately 103 as assessed by a BSL-2 neutralization assay based on vesicular stomatitis virus (VSV) pseudotypes. The poly-ICLC formulated EBOVgp-Fc vaccine protected all the guinea pigs against EBOV lethal challenge performed under BSL-4 conditions whereas the same vaccine formulated with QS-21 or alum only induced partial protection. Vaccination with a mucin-deleted EBOVgp-Fc construct formulated with QS-21 adjuvant did not have a significant effect in anti-GP antibody levels and protection against EBOV lethal challenge compared to the full-length GP construct. The bulk of the humoral response induced by the EBOVgp-Fc vaccine was directed against epitopes outside the EBOV mucin region. Our findings indicate that different adjuvants can eliciting varying levels of protection against lethal EBOV challenge in guinea pigs vaccinated with EBOVgp-Fc, and suggest that levels of total anti-GP antibodies elicit by protein-based GP subunit vaccines do not correlate with protection. Our data further support the development of Fc fusions of GP as a candidate vaccine for human use.
C1 [Konduru, Krishnamurthy; Nakamura, Siham; Kaplan, Gerardo] Food & Drug Adm, Ctr Biol Evaluat & Res, Silver Spring, MD 20993 USA.
[Shurtleff, Amy C.; Bradfute, Steven B.; Bavari, Sina] US Army, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
[Bradfute, Steven B.] Univ New Mexico, Albuquerque, NM 87131 USA.
RP Konduru, K (reprint author), Food & Drug Adm, Ctr Biol Evaluat & Res, Silver Spring, MD 20993 USA.
EM krishnamurthy.konduru@fda.hhs.gov
FU CBER/FDA from National Institutes of Allergy and Infectious Disease
(NIH) [IAA Y1-AI-0664-01]; Defense Threat Reduction Agency (DTRA) [IAA
11005IA-3333-Basic]; FDA; USAMRIID; FDA-U.S. Department of Energy
FX This work was supported by Interagency Agreements (IAAs) with CBER/FDA
(GK) from the National Institutes of Allergy and Infectious Disease (NIH
IAA Y1-AI-0664-01) and the Defense Threat Reduction Agency (DTRA IAA
11005IA-3333-Basic) and intramural funds from FDA (GK) and USAMRIID
(SB). SN was supported by an appointment to a Research Participation
Program administered by the Oak Ridge Institute for Science and
Education through a FDA-U.S. Department of Energy interagency agreement.
The funders had no role in study design, data collection and analysis,
decision to publish, or preparation of the manuscript.
NR 64
TC 0
Z9 0
U1 5
U2 5
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 13
PY 2016
VL 11
IS 9
AR e0162446
DI 10.1371/journal.pone.0162446
PG 21
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA DW5JR
UT WOS:000383681000032
PM 27622456
ER
PT J
AU Shen-Gunther, J
Wang, CM
Poage, GM
Lin, CL
Perez, L
Banks, NA
Huang, THM
AF Shen-Gunther, Jane
Wang, Chiou-Miin
Poage, Graham M.
Lin, Chun-Lin
Perez, Luis
Banks, Nancy A.
Huang, Tim Hui-Ming
TI Molecular Pap smear: HPV genotype and DNA methylation of ADCY8, CDH8,
and ZNF582 as an integrated biomarker for high-grade cervical cytology
SO CLINICAL EPIGENETICS
LA English
DT Article
DE HPV; HPV genotyping; DNA methylation; Pap smear; Pyrosequencing;
Molecular diagnostics; Molecular biomarkers
ID HUMAN-PAPILLOMAVIRUS; INTRAEPITHELIAL NEOPLASIA; ENDOMETRIAL CANCER;
REVEALS; GENES; WOMEN; CARCINOMA; MARKERS; HYPERMETHYLATION;
IDENTIFICATION
AB Background: The Pap smear has remained the foundation for cervical cancer screening for over 70 years. With advancements in molecular diagnostics, primary high-risk human papillomavirus (hrHPV) screening has recently become an accepted stand-alone or co-test with conventional cytology. However, both diagnostic tests have distinct limitations. The aim of this study was to determine the association between HPV genotypes and cellular epigenetic modifications in three grades of cervical cytology for screening biomarker discovery.
Methods: This prospective, cross-sectional study used residual liquid-based cytology samples for HPV genotyping and epigenetic analysis. Extracted DNA was subjected to parallel polymerase chain reactions using three primer sets (MY09/11, FAP59/64, E6-E7 F/B) for HPV DNA amplification. HPV+ samples were genotyped by DNA sequencing. Promoter methylation of four candidate tumor suppressor genes (adenylate cyclase 8 (ADCY8), cadherin 8, type 2 (CDH8), MGMT, and zinc finger protein 582 (ZNF582)) out of 48 genes screened was quantified by bisulfite-pyrosequencing of genomic DNA. Independent validation of methylation profiles was performed by analyzing data from cervical cancer cell lines and clinical samples from The Cancer Genome Atlas (TCGA).
Results: Two hundred seventy-seven quality cytology samples were analyzed. HPV was detected in 31/100 (31 %) negative for intraepithelial lesion or malignancy (NILM), 95/100 (95 %) low-grade squamous intraepithelial lesion (LSIL), and 71/77 (92 %) high-grade squamous intraepithelial lesion (HSIL) samples. The proportion of IARC-defined carcinogenic HPV types in sequenced samples correlated with worsening grade: NILM 7/29 (24 %), LSIL 53/92 (58 %), and HSIL 65/70 (93 %). Promoter methylation of ADCY8, CDH8, and ZNF582 was measured in 170 samples: NILM (N = 33), LSIL (N = 70), and HSIL (N = 67) also correlated with worsening grade. Similar hypermethylation patterns were found in cancer cell lines and TCGA samples. The combination of four biomarkers, i.e., HPV genotype and three-gene promoter methylation, predicted HSIL (AUC 0.89) better than HPV alone (AUC 0.74) by logistic regression and probabilistic modeling.
Conclusions: HPV genotype and DNA methylation of ADCY8, CDH8, and ZNF582 are correlated with cytological grade. Collectively, these biomarkers may serve as a molecular classifier of Pap smears.
C1 [Shen-Gunther, Jane] Brooke Army Med Ctr, Dept Clin Investigat, Gynecol Oncol & Clin Invest, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA.
[Wang, Chiou-Miin; Lin, Chun-Lin; Huang, Tim Hui-Ming] Univ Texas Hlth Sci Ctr San Antonio, Dept Mol Med, Canc Therapy & Res Ctr, San Antonio, TX 78229 USA.
[Poage, Graham M.; Perez, Luis] Brooke Army Med Ctr, Dept Clin Invest, Ft Sam Houston, TX 78234 USA.
[Banks, Nancy A.] Brooke Army Med Ctr, Dept Pathol & Area Labs, Ft Sam Houston, TX 78234 USA.
RP Shen-Gunther, J (reprint author), Brooke Army Med Ctr, Dept Clin Investigat, Gynecol Oncol & Clin Invest, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA.
EM jane.shengunther.mil@mail.mil
FU Dept. of Clinical Investigation Intramural Funding Program at the Brooke
Army Medical Center, Fort Sam Houston, Texas
FX Laboratory materials for this work were supported in part by the Dept.
of Clinical Investigation Intramural Funding Program at the Brooke Army
Medical Center, Fort Sam Houston, Texas.
NR 52
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U1 5
U2 5
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1868-7083
J9 CLIN EPIGENETICS
JI Clin. Epigenetics
PD SEP 13
PY 2016
VL 8
AR 96
DI 10.1186/s13148-016-0263-9
PG 16
WC Oncology
SC Oncology
GA DV8CN
UT WOS:000383165200001
PM 27651839
ER
PT J
AU Hughes, JM
Charkoudian, N
Barnes, JN
Morgan, BJ
AF Hughes, Julie M.
Charkoudian, Nisha
Barnes, Jill N.
Morgan, Barbara J.
TI Revisiting the Debate: Does Exercise Build Strong Bones in the Mature
and Senescent Skeleton?
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Article
DE osteogenesis; mechanical loading; aging; sympathetic nervous system;
beta-adrenergic receptor; periosteum
ID WHOLE-BODY VIBRATION; RANDOMIZED CONTROLLED-TRIAL; SYMPATHETIC-NERVE
ACTIVITY; SPINAL-CORD-INJURY; POSTMENOPAUSAL WOMEN; LOW-MAGNITUDE;
PHYSICAL-ACTIVITY; CORTICAL BONE; MECHANICAL-PROPERTIES; MINERAL DENSITY
AB Traditional exercise programs seem to be less osteogenic in the mature and post-mature skeleton compared to the young skeleton. This is likely because of the decline in sensitivity of bone to mechanical loading that occurs with advancing age. Another factor contributing to the apparently diminished benefit of exercise in older adults is failure of widely used measurement techniques (i.e., DXA) to identify changes in 3-dimensional bone structure, which are important determinants of bone strength. Moreover, although hormonal contributors to bone loss in the elderly are well-recognized, the influence of age-related increases in sympathetic nervous system activity, which impacts bone metabolism, is rarely considered. In this Perspective, we cite evidence from animal and human studies demonstrating anabolic effects of exercise on bone across the lifespan and we discuss theoretical considerations for designing exercise regimens to optimize bone health. We conclude with suggestions for future research that should help define the osteogenic potential of exercise in older individuals.
C1 [Hughes, Julie M.] US Army Res Inst Environm Med, Mil Performance Div, Natick, MA USA.
[Charkoudian, Nisha] US Army Res Inst Environm Med, Thermal & Mt Med Div, Natick, MA USA.
[Barnes, Jill N.] Univ Wisconsin, Bruno Balke Biodynam Lab, Dept Kinesiol, Madison, WI USA.
[Morgan, Barbara J.] Univ Wisconsin, Dept Orthopaed & Rehabil, John Rankin Lab Pulm Med, Madison, WI 53706 USA.
RP Morgan, BJ (reprint author), Univ Wisconsin, Dept Orthopaed & Rehabil, John Rankin Lab Pulm Med, Madison, WI 53706 USA.
EM bjmorgan@wisc.edu
NR 99
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U1 9
U2 9
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015,
SWITZERLAND
SN 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD SEP 13
PY 2016
VL 7
AR 369
DI 10.3389/fphys.2016.00369
PG 8
WC Physiology
SC Physiology
GA DV4UP
UT WOS:000382921100001
PM 27679578
ER
PT J
AU Zhu, WB
Chao, JH
Chen, CJ
Yin, SZ
Hoffman, RC
AF Zhu, Wenbin
Chao, Ju-Hung
Chen, Chang-Jiang
Yin, Shizhuo
Hoffman, Robert C.
TI Three order increase in scanning speed of space charge-controlled KTN
deflector by eliminating electric field induced phase transition in
nanodisordered KTN
SO SCIENTIFIC REPORTS
LA English
DT Article
ID TANTALATE-NIOBATE CRYSTALS; WAVE-GUIDES; KTA1-XNBXO3
AB In this paper, we report a three orders-of-magnitude increase in the speed of a space-charge-controlled KTN beam deflector achieved by eliminating the electric field-induced phase transition (EFIPT) in a nanodisordered KTN crystal. Previously, to maximize the electro-optic effect, a KTN beam deflector was operated at a temperature slightly above the Curie temperature. The electric field could cause the KTN to undergo a phase transition from the paraelectric phase to the ferroelectric phase at this temperature, which causes the deflector to operate in the linear electro-optic regime. Since the deflection angle of the deflector is proportional to the space charge distribution but not the magnitude of the applied electric field, the scanning speed of the beam deflector is limited by the electron mobility within the KTN crystal. To overcome this speed limitation caused by the EFIPT, we propose to operate the deflector at a temperature above the critical end point. This results in a significant increase in the scanning speed from the microsecond to nanosecond regime, which represents a major technological advance in the field of fast speed beam scanners. This can be highly beneficial for many applications including high-speed imaging, broadband optical communications, and ultrafast laser display and printing.
C1 [Zhu, Wenbin; Chao, Ju-Hung; Chen, Chang-Jiang; Yin, Shizhuo] Penn State Univ, Dept Elect Engn, University Pk, PA 16802 USA.
[Hoffman, Robert C.] US Army, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
RP Yin, SZ (reprint author), Penn State Univ, Dept Elect Engn, University Pk, PA 16802 USA.
EM sxy105@psu.edu
FU Army Research Laboratory [W911NF-14-2-0067]
FX This research was sponsored and partially supported by the Army Research
Laboratory and was accomplished under Cooperative Agreement Number
W911NF-14-2-0067. The views and conclusions contained in this document
are those of the authors and should not be interpreted as representing
the official policies, either expressed or implied, of the Army Research
Laboratory or the US Government. The US Government is authorized to
reproduce and distribute reprints for Government purposes
notwithstanding any copyright notation heron.
NR 26
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U1 6
U2 6
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD SEP 9
PY 2016
VL 6
AR 33143
DI 10.1038/srep33143
PG 10
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA DV3YP
UT WOS:000382862100001
PM 27610923
ER
PT J
AU Abbink, P
Larocca, RA
De La Barrera, RA
Bricault, CA
Moseley, ET
Boyd, M
Kirilova, M
Li, ZF
Ng'ang'a, D
Nanayakkara, O
Nityanandam, R
Mercado, NB
Borducchi, EN
Agarwal, A
Brinkman, AL
Cabral, C
Chandrashekar, A
Giglio, PB
Jetton, D
Jimenez, J
Lee, BC
Mojta, S
Molloy, K
Shetty, M
Neubauer, GH
Stephenson, KE
Peron, JPS
Zanotto, PMD
Misamore, J
Finneyfrock, B
Lewis, MG
Alter, G
Modjarrad, K
Jarman, RG
Eckels, KH
Michael, NL
Thomas, SJ
Barouch, DH
AF Abbink, Peter
Larocca, Rafael A.
De La Barrera, Rafael A.
Bricault, Christine A.
Moseley, Edward T.
Boyd, Michael
Kirilova, Marinela
Li, Zhenfeng
Ng'ang'a, David
Nanayakkara, Ovini
Nityanandam, Ramya
Mercado, Noe B.
Borducchi, Erica N.
Agarwal, Arshi
Brinkman, Amanda L.
Cabral, Crystal
Chandrashekar, Abishek
Giglio, Patricia B.
Jetton, David
Jimenez, Jessica
Lee, Benjamin C.
Mojta, Shanell
Molloy, Katherine
Shetty, Mayuri
Neubauer, George H.
Stephenson, Kathryn E.
Peron, Jean Pierre S.
Zanotto, Paolo M. de A.
Misamore, Johnathan
Finneyfrock, Brad
Lewis, Mark G.
Alter, Galit
Modjarrad, Kayvon
Jarman, Richard G.
Eckels, Kenneth H.
Michael, Nelson L.
Thomas, Stephen J.
Barouch, Dan H.
TI Protective efficacy of multiple vaccine platforms against Zika virus
challenge in rhesus monkeys
SO SCIENCE
LA English
DT Article
ID JAPANESE ENCEPHALITIS; INFECTION; MICE; ANTIBODIES; ORGANOIDS
AB Zika virus (ZIKV) is responsible for a major ongoing epidemic in the Americas and has been causally associated with fetal microcephaly. The development of a safe and effective ZIKV vaccine is therefore an urgent global health priority. Here we demonstrate that three different vaccine platforms protect against ZIKV challenge in rhesus monkeys. A purified inactivated virus vaccine induced ZIKV-specific neutralizing antibodies and completely protected monkeys against ZIKV strains from both Brazil and Puerto Rico. Purified immunoglobulin from vaccinated monkeys also conferred passive protection in adoptive transfer studies. A plasmid DNA vaccine and a single-shot recombinant rhesus adenovirus serotype 52 vector vaccine, both expressing ZIKV premembrane and envelope, also elicited neutralizing antibodies and completely protected monkeys against ZIKV challenge. These data support the rapid clinical development of ZIKV vaccines for humans.
C1 [Abbink, Peter; Larocca, Rafael A.; Bricault, Christine A.; Moseley, Edward T.; Boyd, Michael; Kirilova, Marinela; Li, Zhenfeng; Ng'ang'a, David; Nanayakkara, Ovini; Nityanandam, Ramya; Mercado, Noe B.; Borducchi, Erica N.; Agarwal, Arshi; Brinkman, Amanda L.; Cabral, Crystal; Chandrashekar, Abishek; Giglio, Patricia B.; Jetton, David; Jimenez, Jessica; Lee, Benjamin C.; Mojta, Shanell; Molloy, Katherine; Shetty, Mayuri; Neubauer, George H.; Stephenson, Kathryn E.; Barouch, Dan H.] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Ctr Virol & Vaccine Res, Boston, MA 02215 USA.
[De La Barrera, Rafael A.; Modjarrad, Kayvon; Jarman, Richard G.; Eckels, Kenneth H.; Michael, Nelson L.; Thomas, Stephen J.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA.
[Peron, Jean Pierre S.; Zanotto, Paolo M. de A.] Univ Sao Paulo, BR-05508000 Sao Paulo, Brazil.
[Misamore, Johnathan; Finneyfrock, Brad; Lewis, Mark G.] Bioqual, Rockville, MD 20852 USA.
[Alter, Galit; Barouch, Dan H.] Ragon Inst MGH MIT & Harvard, Cambridge, MA 02139 USA.
[Modjarrad, Kayvon] Henry M Jackson Fdn, Bethesda, MD 20817 USA.
RP Barouch, DH (reprint author), Harvard Med Sch, Beth Israel Deaconess Med Ctr, Ctr Virol & Vaccine Res, Boston, MA 02215 USA.; Barouch, DH (reprint author), Ragon Inst MGH MIT & Harvard, Cambridge, MA 02139 USA.
EM dbarouch@bidmc.harvard.edu
FU U.S. Military Research and Materiel Command; U.S. Military HIV Research
Program; Henry M. Jackson Foundation [W81XWH-11-2-0174]; National
Institutes of Health [AI095985, AI096040, AI100663, AI124377]; Ragon
Institute of MGH; MIT; Harvard; Sao Paulo Research Foundation (FAPESP)
[2011/18703-2, 2014/17766-9]
FX We thank J. Mascola, B. Graham, H. Marston, P. Vasconcelos, N. Collins,
R. Olson, K. Kabra, C. Springer, G. Ballarini, N. Botero, K. Chandrika,
G. Donofrio, M. Robb, D. Weiss, A. Cook, J. Campbell, S. Hetzel, U.
Reimer, H. Wenschuh, T. Suscovich, C. Linde, R. Lu, L. Peter, J. Le
Suer, P. Gandhi, M. Iampietro, K. Visitsunthorn, A. Badamchi-Zadeh, L.
Maxfield, and F. Stephens for generous advice, assistance, and reagents.
The data from this study are tabulated in the main paper and in the
supplementary materials. P. A., R. A. L., D. H. B., R. G. J., K.H.E.,
and S. J. T. are co-inventors on pending patent applications related to
ZIKV vaccines, antigens, and vectors, and licensure discussions with
industry partners are currently ongoing. P. A. and D. H. B. are
cofounders and equity holders in AVVI Biotech. ZIKV challenge stocks and
vaccine constructs are available with appropriate material transfer
agreements. We acknowledge support from the U.S. Military Research and
Materiel Command and the U.S. Military HIV Research Program through its
cooperative agreement with the Henry M. Jackson Foundation
(W81XWH-11-2-0174); the National Institutes of Health (grants AI095985,
AI096040, AI100663, and AI124377); the Ragon Institute of MGH, MIT, and
Harvard; and the Sao Paulo Research Foundation (FAPESP; grants
2011/18703-2 and 2014/17766-9). The views expressed in this manuscript
are those of the authors and do not represent the official views of the
Department of the Army or the Department of Defense.
NR 30
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U2 75
PU AMER ASSOC ADVANCEMENT SCIENCE
PI WASHINGTON
PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA
SN 0036-8075
EI 1095-9203
J9 SCIENCE
JI Science
PD SEP 9
PY 2016
VL 353
IS 6304
BP 1129
EP 1132
DI 10.1126/science.aah6157
PG 4
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA DV0RN
UT WOS:000382626800047
PM 27492477
ER
PT J
AU Sorescu, DC
Rice, BM
AF Sorescu, Dan C.
Rice, Betsy M.
TI RDX Compression, alpha -> gamma Phase Transition, and Shock Hugoniot
Calculations from Density-Functional-Theory-Based Molecular Dynamics
Simulations
SO JOURNAL OF PHYSICAL CHEMISTRY C
LA English
DT Article
ID SPACE GAUSSIAN PSEUDOPOTENTIALS; REACTIVE FORCE-FIELD;
EQUATION-OF-STATE; 1,3,5,7-TETRANITRO-1,3,5,7-TETRAAZACYCLOOCTANE HMX;
CYCLOTRIMETHYLENE-TRINITRAMINE; HYDROSTATIC COMPRESSION; ENERGETIC
MATERIALS; NITRAMINE CRYSTALS; AB-INITIO; DFT-D
AB Prediction of the density and lattice compression properties of the alpha and gamma phases, of the hexahyClro-1,3,5-trinitr-1,3,5-s-triazine (RDX) crystal and of the low-pressure alpha -> gamma phase transition upon pressure:increase are general tests used to assess the accuracy of density-functional theory (DFT) based computational methods and to identify the essential parameters that govern the behavior of-this high-energy-density material under extreme conditions. The majority of previous DFT-Studies have analyzed such issues under static optimization conditions by neglecting the corresponding temperature effects. In this study, we extend previous, investigations and analyze the performance of dispersion-corrected density functional theory to predict the compression 9y phase transition under realistic-temperature and pressure conditions. We demonstrate that, by using static dispersion-corrected density functional theory-calculations,. direct interconversion between the ice and gamma Phases upon compression is not observed. This limitation can be addressed by using isobaric isothermat molecular dynamic simulations in conjunction with DFT-D2-calculated potentials, an approach that is shown to provide Ian accurate description of both the crystallographic RDX. lattice parameters and the dynamical effects associated with the alpha -> gamma phase transformation. An even more comprehensive and demanding analysis was done by predicting, the corresponding Shock Hugoniot curve of RDX in the pressure, range of 0-9 GPa: It was found that the theoretical results reproduce reasonably well the available experimental Hugoniot shock data for both the alpha- and gamma phases. The results obtained demonstrate that a satisfactory prediction of the shock properties in high-euergy-density Materials undergoing,crystallographic and configurational transformations is possible through the combined use of molecular dynamics simulations in the isobaric isothermal ensemble with dispersiOn-corrected density functional theory methods.
C1 [Sorescu, Dan C.] US DOE, Natl Energy Technol Lab, Pittsburgh, PA 15236 USA.
[Rice, Betsy M.] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RP Sorescu, DC (reprint author), US DOE, Natl Energy Technol Lab, Pittsburgh, PA 15236 USA.
EM sorescu@netl.doe.gov
NR 51
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U1 20
U2 20
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1932-7447
J9 J PHYS CHEM C
JI J. Phys. Chem. C
PD SEP 8
PY 2016
VL 120
IS 35
BP 19547
EP 19557
DI 10.1021/acs.jpcc.6b06415
PG 11
WC Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science,
Multidisciplinary
SC Chemistry; Science & Technology - Other Topics; Materials Science
GA DV5XT
UT WOS:000383004700007
ER
PT J
AU Wanja, EW
Kuya, N
Moranga, C
Hickman, M
Johnson, JD
Moseti, C
Anova, L
Ogutu, B
Ohrt, C
AF Wanja, Elizabeth W.
Kuya, Nickline
Moranga, Collins
Hickman, Mark
Johnson, Jacob D.
Moseti, Carolyne
Anova, Lalaine
Ogutu, Bernhards
Ohrt, Colin
TI Field evaluation of diagnostic performance of malaria rapid diagnostic
tests in western Kenya
SO MALARIA JOURNAL
LA English
DT Article
DE Malaria; Microscopy; Rapid diagnostic tests; Performance; Western Kenya
ID POLYMERASE-CHAIN-REACTION; FALCIPARUM-MALARIA; FEBRILE PATIENTS;
PLASMODIUM; MICROSCOPY; ELIMINATION; CHALLENGES; PREGNANCY; TRAVELERS;
HEALTH
AB Background: Malaria continues to be a major burden in the endemic regions of Kenya. Health outcomes associated with case management are dependent on the use of appropriate diagnostic methods. Rapid diagnostic tests (RDTs) have provided an important tool to help implement the WHO recommended parasite-based diagnosis in regions where expert microscopy is not available. One of the questions that must be answered when implementing RDTs is whether these tests are useful in a specific endemic region, as well as the most appropriate RDT to use. Data on the sensitivity and specificity of RDT test kits is important information to help guide test selection by national malaria control programmes.
Methods: This study evaluated the diagnostic performance of RDTs including First Response (FR), CareStart (CS), SD Bioline (SD), and Binax Now (BN). The performance of these malaria kits was compared to microscopy, the gold standard, for the detection of malaria parasites. The malaria RDTs were also compared to PCR which is a more sensitive reference test. Five-hundred participants were included in the study through community screening (50 %) and testing suspected malaria cases referred from health facilities.
Results: Of the 500 participants recruited, 33 % were malaria positive by microscopy while 51.2 % were positive by PCR. Compared to microscopy, the sensitivity of eight RDTs to detect malaria parasites was 90.3-94.8 %, the specificity was 73.3-79.3 %, the positive predictive value was 62.2-68.8 %, and the negative predictive value was 94.3-96.8 %. Compared to PCR, the sensitivity of the RDTs to detect malaria parasites was 71.1-75.4 %, the specificity was 80.3-84.4 %, the positive predictive value was 80.3-83.3 %, and the negative predictive value was 73.7-76.1 %. The RDTs had a moderate measure of agreement with both microscopy (>80.1 %) and PCR (>77.6 %) with a kappa > 0.6.
Conclusion: The performance of the evaluated RDTs using field samples was moderate; hence they can significantly improve the quality of malaria case management in endemic regions in Kenya by ensuring appropriate treatment of malaria positive individuals and avoiding indiscriminate use of anti-malarial drugs for parasite negative patients.
C1 [Wanja, Elizabeth W.; Kuya, Nickline; Moranga, Collins; Moseti, Carolyne; Ogutu, Bernhards] Kenya Govt Med Res Ctr, US Army Med Res Unit, Malaria Diagnost Ctr, Box 54, Kisumu 40100, Kenya.
[Hickman, Mark; Anova, Lalaine] Walter Reed Army Inst Res, Div Expt Therapeut, Silver Spring, MD 20910 USA.
[Johnson, Jacob D.] Madigan Army Med Ctr, 9040 Jackson Ave, Tacoma, WA 98431 USA.
[Ohrt, Colin] Translat Med Int LLC, 35 Trung Van Rd, Hanoi, Vietnam.
RP Wanja, EW (reprint author), Kenya Govt Med Res Ctr, US Army Med Res Unit, Malaria Diagnost Ctr, Box 54, Kisumu 40100, Kenya.
EM Elizabeth.Wanja.mil@afrims.org
FU Armed Forces Health Surveillance Center-Global Emerging Infections
Surveillance and Response System funding (AFHSC-GEIS) [P0046_14_KY]
FX This work was supported by the Armed Forces Health Surveillance
Center-Global Emerging Infections Surveillance and Response System
funding (AFHSC-GEIS, Proposal# P0046_14_KY).
NR 33
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U1 7
U2 7
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1475-2875
J9 MALARIA J
JI Malar. J.
PD SEP 7
PY 2016
VL 15
AR 456
DI 10.1186/s12936-016-1508-y
PG 10
WC Infectious Diseases; Parasitology; Tropical Medicine
SC Infectious Diseases; Parasitology; Tropical Medicine
GA DU9LB
UT WOS:000382537500001
PM 27604888
ER
PT J
AU Ralph, JF
Jacobs, K
Coleman, J
AF Ralph, Jason F.
Jacobs, Kurt
Coleman, Jonathon
TI Coupling rotational and translational motion via a continuous
measurement in an optomechanical sphere
SO PHYSICAL REVIEW A
LA English
DT Article
ID QUANTUM; PARTICLES; MODELS; ATOMS; STATE
AB We consider a measurement of the position of a spot painted on the surface of a trapped nano-optomechanical sphere. The measurement extracts information about the position of the spot and in doing so measures a combination of the orientation and position of the sphere. The quantum backaction of the measurement entangles and correlates these two degrees of freedom. Such a measurement is not available for atoms or ions and provides a mechanism to probe the quantum mechanical properties of trapped optomechanical spheres. In performing simulations of this measurement process we also test a numerical method introduced recently by Rouchon and collaborators [H. Amini, M. Mirrahimi, and P. Rouchon, in Proceedings of the 50th IEEE Conference on Decision and Control (CDC, 2011), pp. 6242-6247; P. Rouchon and J. F. Ralph, Phys. Rev. A 91, 012118 (2015)] for solving stochastic master equations. This method guarantees the positivity of the density matrix when the Lindblad operators for all simultaneous continuous measurements are mutually commuting. We show that it is both simpler and far more efficient than previous methods.
C1 [Ralph, Jason F.] Univ Liverpool, Dept Elect & Elect Engn, Brownlow Hill, Liverpool L69 3GJ, Merseyside, England.
[Jacobs, Kurt] US Army, Res Lab, Computat & Informat Sci Directorate, Adelphi, MD 20783 USA.
[Jacobs, Kurt] Univ Massachusetts, Dept Phys, Boston, MA 02125 USA.
[Jacobs, Kurt] Louisiana State Univ, Hearne Inst Theoret Phys, Baton Rouge, LA 70803 USA.
[Coleman, Jonathon] Univ Liverpool, Dept Phys, Oxford St, Liverpool L69 7ZE, Merseyside, England.
RP Ralph, JF (reprint author), Univ Liverpool, Dept Elect & Elect Engn, Brownlow Hill, Liverpool L69 3GJ, Merseyside, England.
EM jfralph@liverpool.ac.uk; kurt.jacobs@umb.edu; coleman@liverpool.ac.uk
NR 51
TC 0
Z9 0
U1 3
U2 3
PU AMER PHYSICAL SOC
PI COLLEGE PK
PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA
SN 2469-9926
EI 2469-9934
J9 PHYS REV A
JI Phys. Rev. A
PD SEP 7
PY 2016
VL 94
IS 3
AR 032108
DI 10.1103/PhysRevA.94.032108
PG 10
WC Optics; Physics, Atomic, Molecular & Chemical
SC Optics; Physics
GA DV1YE
UT WOS:000382717200004
ER
PT J
AU Whitehead, JMA
Esposito, ER
Wilken, JM
AF Whitehead, Jennifer M. Aldridge
Esposito, Elizabeth Russell
Wilken, Jason M.
TI Stair ascent and descent biomechanical adaptations while using a custom
ankle-foot orthosis
SO JOURNAL OF BIOMECHANICS
LA English
DT Article
DE Kinetics; Kinematics; Limb salvage; Limb preservation; Military; IDEO
ID LOWER-EXTREMITY TRAUMA; HEALTHY-ADULTS; LIMB SALVAGE; TRANSTIBIAL
AMPUTATION; PHYSICAL-THERAPY; GAIT; KNEE; AMBULATION; KINETICS;
KINEMATICS
AB The ability to navigate stairs step-over-step is an important functional outcome following severe lower leg injury and is difficult for many patients. Ankle-foot orthoses, such as the Intrepid Dynamic Exoskeletal Orthosis (IDEO), are often prescribed to improve function. This study compared stair climbing mechanics between IDEO users and able-bodied control participants. Thirteen IDEO users who sustained severe lower leg injury and 13 controls underwent biomechanical gait analysis. Participants ascended and descended a 16-step instrumented staircase without handrail use at a controlled cadence of 80 steps/ min. Peak joint angles, moments, powers, and ground reaction forces, and integrated mechanical work were calculated. Independent t-tests with Bonferroni-Holm corrections were used to compare controls to IDEO and sound limbs. Reduced ankle range of motion on the IDEO limb resulted in compensatory strategies while ascending or descending stairs. During ascent, IDEO users had greater bilateral hip power during pull-up (p < 0.007) to compensate for the IDEO limb's reduced ankle dorsiflexion (p <0.001) and knee extensor moment (p= 0.001) while it was leading, and reduced ankle plantarfiexor power while it was trailing (p < 0.001). During stair descent, when the IDEO limb had was trailing, it had less ankle dorsiflexion during controlled lowering (p < 0.001), resulting in greater vertical ground reaction force (p= 0.005) and greater ankle and knee power absorption (p < 0.001). Reduced IDEO limb ankle power absorption during weight acceptance (p < 0.001) resulted in a large knee extensor moment (p < 0.001) on the trailing sound limb to lower the body. Despite gait deviations, IDEO users were able to climb stairs step-over-step unassisted. Published by Elsevier Ltd.
C1 [Whitehead, Jennifer M. Aldridge; Esposito, Elizabeth Russell; Wilken, Jason M.] Brooke Army Med Ctr, Dept Orthopaed & Rehabil, Ctr Intrepid, Jbsa Ft Sam Houston, TX USA.
[Whitehead, Jennifer M. Aldridge; Esposito, Elizabeth Russell; Wilken, Jason M.] Extrem Trauma & Amputat Ctr Excellence, Falls Church, VA USA.
RP Esposito, ER (reprint author), 3551 Roger Brooke Dr, Jbsa Ft Sam Houston, TX 78234 USA.
EM Erussell.kin@gmail.com
FU Center for Rehabilitation Sciences Research; Department of Physical
Medicine and Rehabilitation; Uniformed Services University of Health
Sciences, Bethesda, MD, USA
FX We acknowledge Kelly Rodriguez, Deanna Gates, and Derek Haight for
assistance with data collection and Ryan Blanck and Lance Suggs for
orthotic assistance. This work was funded by The Center for
Rehabilitation Sciences Research, Department of Physical Medicine and
Rehabilitation, Uniformed Services University of Health Sciences,
Bethesda, MD, USA.
NR 36
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U1 5
U2 5
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0021-9290
EI 1873-2380
J9 J BIOMECH
JI J. Biomech.
PD SEP 6
PY 2016
VL 49
IS 13
BP 2899
EP 2908
DI 10.1016/j.jbiomech.2016.06.035
PG 10
WC Biophysics; Engineering, Biomedical
SC Biophysics; Engineering
GA DY9RH
UT WOS:000385472300045
PM 27451057
ER
PT J
AU Tang, YH
Mandal, KC
McGuire, JA
Lai, CW
AF Tang, Yanhao
Mandal, Krishna C.
McGuire, John A.
Lai, Chih Wei
TI Layer- and frequency-dependent second harmonic generation in reflection
from GaSe atomic crystals
SO PHYSICAL REVIEW B
LA English
DT Article
ID GALLIUM SELENIDE; EPSILON-GASE; EXCITONS; LIGHT; GAP
AB We report optical second-harmonic generation (SHG) in reflection from GaSe crystals of 1 to more than 100 layers using a fundamental picosecond pulsed pump at 1.58 eV and a supercontinuum white light pulsed laser with energies ranging from 0.85 to 1.4 eV. The measured reflected SHG signal is maximal in samples of similar to 20 layers, decreasing in thicker samples as a result of interference. The thickness-and frequency-dependence of the SHG response of samples thicker than similar to 7 layers can be reproduced by a second-order optical susceptibility that is the same as in bulk samples. For samples similar to 7 layers, the second-order optical susceptibility is reduced compared to that in thicker samples, which is attributed to the expected band-gap increase in mono-and few-layer GaSe.
C1 [Tang, Yanhao; McGuire, John A.; Lai, Chih Wei] Michigan State Univ, Dept Phys & Astron, E Lansing, MI 48824 USA.
[Mandal, Krishna C.] Univ South Carolina, Dept Elect Engn, Columbia, SC 29208 USA.
[Lai, Chih Wei] Lawrence Berkeley Natl Lab, Div Mat Sci, Berkeley, CA 94720 USA.
[Lai, Chih Wei] US Army, Res Lab, Adelphi, MD 20783 USA.
RP McGuire, JA (reprint author), Michigan State Univ, Dept Phys & Astron, E Lansing, MI 48824 USA.
EM mcguire@pa.msu.edu; cwlai@msu.edu
RI McGuire, John/C-3380-2015; Lai, Chih Wei/E-4945-2010
OI McGuire, John/0000-0002-0682-0953; Lai, Chih Wei/0000-0003-3571-4671
FU NSF [DMR-09055944]; Michigan State University
FX We thank Brage Golding for discussions. This work was supported by NSF
Grant No. DMR-09055944 as well as start-up funding and the Cowen
endowment at Michigan State University. This research has used the W. M.
Keck Microfabrication Facility.
NR 29
TC 0
Z9 0
U1 23
U2 23
PU AMER PHYSICAL SOC
PI COLLEGE PK
PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA
SN 2469-9950
EI 2469-9969
J9 PHYS REV B
JI Phys. Rev. B
PD SEP 6
PY 2016
VL 94
IS 12
AR 125302
DI 10.1103/PhysRevB.94.125302
PG 6
WC Physics, Condensed Matter
SC Physics
GA DV9BT
UT WOS:000383235000010
ER
PT J
AU Teja-Isavadharm, P
Siriyanonda, D
Rasameesoraj, M
Limsalakpeth, A
Chanarat, N
Komcharoen, N
Weina, PJ
Saunders, DL
Gettayacamin, M
Miller, RS
AF Teja-Isavadharm, Paktiya
Siriyanonda, Duangsuda
Rasameesoraj, Maneerat
Limsalakpeth, Amporn
Chanarat, Nitima
Komcharoen, Natthasorn
Weina, Peter J.
Saunders, David L.
Gettayacamin, Montip
Miller, R. Scott
TI Comparative pharmacokinetics and pharmacodynamics of intravenous
artelinate versus artesunate in uncomplicated Plasmodium
coatneyi-infected rhesus monkey model
SO MALARIA JOURNAL
LA English
DT Article
DE Monkey malaria; Artelinic; Artelinate; Artesunate; Pharmacokinetics;
Pharmacodynamics; Parasite clearance
ID SEVERE FALCIPARUM-MALARIA; PARASITE CLEARANCE; HEALTHY-VOLUNTEERS;
UNINFECTED RATS; 8 MG/KG; BERGHEI; QUININE; ACID; BIOAVAILABILITY;
METABOLISM
AB Background: The US Army designed artelinate/lysine salt (AL) to overcome the instability of sodium artesunate in aqueous solution (AS). To select the most efficacious artemisinin treatment, direct comparison was performed in an uncomplicated non-human primate malaria model.
Methods: Splenectomized rhesus monkeys were inoculated with Plasmodium coatneyi and on day six, single equi-molar loading dose of IV AL (11.8 mg kg(-1)) or IV AS (8 mg kg(-1)) were administered followed by 1/2 the first dose once daily for 2 more days. Blood smear were performed twice daily and the number of parasites were counted microscopically. Blood samples were obtained after the first dose within 6 h for pharmacokinetic (PK) and ex vivo pharmacodynamic evaluation by simultaneously measuring plasma drug concentration and anti-malarial activity against Plasmodium falciparum in vitro.
Results: The anti-P. coatneyi in vivo activity of both compounds were comparable, but the ex vivo anti-P. falciparum potency of the IV AS regimen as administered was sevenfold higher than that of IV AL. Comparing in vivo pharmacodynamics of AL and AS, daily assessed parasite counts showed comparable 99 % parasite clearance times (PC99: 2.03, 1.84 day), parasite clearance rates (5.34, 4.13 per min) and clearance half-life (PCt(1/2): 7.79, 10.1 h). This study showed strong and significant inverse correlation between PCt(1/2) and t(1/2) of AS + DHA, and AUC(0-infinity) of DHA, and correlated with V-z of AS (r(2) > 0.7, p = 0.002). Lastly, following IV AL, there was a modest inverse correlation between PCt(1/2) and C-max (r(2) 0.6, p = 0.04). Although all tested monkeys recrudesced subsequently, two died following AL regimen before parasite clearance. While the aetiology of those deaths could not be definitively determined, pathologic evidence favoured a sepsis-like syndrome and suggested that severe malaria was more likely than drug toxicity.
Conclusion: The model demonstrated that both AS and DHA contributed to the anti-malarial activity of IV AS, while IV AL activity was largely restricted to the parent drug. Parasite clearance was strongly and linearly dependent on drug exposure for both artemisinin regimens. However, IV AS had higher ex vivo potency against P. falciparum, leading to an IND filing for GMP manufactured AS in the United States.
C1 [Teja-Isavadharm, Paktiya; Siriyanonda, Duangsuda; Rasameesoraj, Maneerat; Limsalakpeth, Amporn; Chanarat, Nitima; Saunders, David L.; Miller, R. Scott] Armed Forces Res Inst Med Sci, Dept Immunol & Med, 315-6 Rajvithi Rd, Bangkok 10400, Thailand.
[Komcharoen, Natthasorn; Gettayacamin, Montip] Armed Forces Res Inst Med Sci, Dept Vet Med, 315-6 Rajvithi Rd, Bangkok 10400, Thailand.
[Weina, Peter J.] Walter Reed Army Inst Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
[Weina, Peter J.] Walter Reed Natl Mil Med Ctr, Director Res Programs, Bethesda, MD 20889 USA.
[Saunders, David L.] US Army, Med Mat Act Ft Detrick, Frederick, MD 21702 USA.
[Gettayacamin, Montip] AAALAC Int Southeast Asia Off, Bangplee 10540, Samutprakarn, Thailand.
[Miller, R. Scott] Bill & Melinda Gates Fdn, Global Hlth Div, 250-830 Moo3,Bangpla Soi 18, Seattle, WA USA.
RP Teja-Isavadharm, P (reprint author), Armed Forces Res Inst Med Sci, Dept Immunol & Med, 315-6 Rajvithi Rd, Bangkok 10400, Thailand.
EM paktiyat@gmail.com
FU Military Infectious Disease Research Program (MIDRP) "Drug to treat
multi-drug resistant and severe and complicated malaria" [MIDRP STO
AQ00012_01_AF, AQ00012_02_AF AQ0008_02_AF]
FX This work was supported by Military Infectious Disease Research Program
(MIDRP) "Drug to treat multi-drug resistant and severe and complicated
malaria" under proposal MIDRP STO AQ00012_01_AF AND AQ00012_02_AF
AQ0008_02_AF. Material has been reviewed by the Walter Reed Army
Institute of Research. There is no objection to its presentation and/or
publication. The opinions or assertions contained herein are the private
views of the author, and are not to be construed as official, or as
reflecting true views of the Department of the Army or the Department of
Defense.
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PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1475-2875
J9 MALARIA J
JI Malar. J.
PD SEP 6
PY 2016
VL 15
AR 453
DI 10.1186/s12936-016-1456-6
PG 15
WC Infectious Diseases; Parasitology; Tropical Medicine
SC Infectious Diseases; Parasitology; Tropical Medicine
GA DU9LA
UT WOS:000382537400001
PM 27599723
ER
PT J
AU Caballero, IS
Honko, AN
Gire, SK
Winnicki, SM
Mele, M
Gerhardinger, C
Lin, AE
Rinn, JL
Sabeti, PC
Hensley, LE
Connor, JH
AF Caballero, Ignacio S.
Honko, Anna N.
Gire, Stephen K.
Winnicki, Sarah M.
Mele, Marta
Gerhardinger, Chiara
Lin, Aaron E.
Rinn, John L.
Sabeti, Pardis C.
Hensley, Lisa E.
Connor, John H.
TI In vivo Ebola virus infection leads to a strong innate response in
circulating immune cells
SO BMC GENOMICS
LA English
DT Article
DE Ebola virus; Transcriptional response; Transcriptomics;
Interferon-stimulated genes
ID HEMORRHAGIC-FEVER; GENE-EXPRESSION; NONHUMAN-PRIMATES; CYNOMOLGUS
MACAQUES; ZAIRE-EBOLAVIRUS; RHESUS MACAQUES; MARBURG VIRUSES; RNA;
CHALLENGE; REVEALS
AB Background: Ebola virus is the causative agent of a severe syndrome in humans with a fatality rate that can approach 90 %. During infection, the host immune response is thought to become dysregulated, but the mechanisms through which this happens are not entirely understood. In this study, we analyze RNA sequencing data to determine the host response to Ebola virus infection in circulating immune cells.
Results: Approximately half of the 100 genes with the strongest early increases in expression were interferon-stimulated genes, such as ISG15, OAS1, IFIT2, HERC5, MX1 and DHX58. Other highly upregulated genes included cytokines CXCL11, CCL7, IL2RA, IL2R1, IL15RA, and CSF2RB, which have not been previously reported to change during Ebola virus infection. Comparing this response in two different models of exposure (intramuscular and aerosol) revealed a similar signature of infection. The strong innate response in the aerosol model was seen not only in circulating cells, but also in primary and secondary target tissues. Conversely, the innate immune response of vaccinated macaques was almost non-existent. This suggests that the innate response is a major aspect of the cellular response to Ebola virus infection in multiple tissues.
Conclusions: Ebola virus causes a severe infection in humans that is associated with high mortality. The host immune response to virus infection is thought to be an important aspect leading to severe pathology, but the components of this overactive response are not well characterized. Here, we analyzed how circulating immune cells respond to the virus and found that there is a strong innate response dependent on active virus replication. This finding is in stark contrast to in vitro evidence showing a suppression of innate immune signaling, and it suggests that the strong innate response we observe in infected animals may be an important contributor to pathogenesis.
C1 [Caballero, Ignacio S.] Boston Univ, Bioinformat Grad Program, Boston, MA 02215 USA.
[Honko, Anna N.; Hensley, Lisa E.] US Army, Med Res Inst Infect Dis, Virol Div, Ft Detrick, MD 21702 USA.
[Honko, Anna N.; Hensley, Lisa E.] NIAID, Integrated Res Facil, NIH, Ft Detrick, MD USA.
[Gire, Stephen K.; Winnicki, Sarah M.; Mele, Marta; Gerhardinger, Chiara; Lin, Aaron E.; Rinn, John L.; Sabeti, Pardis C.] Harvard Univ, Dept Organism & Evolutionary Biol, Ctr Syst Biol, Cambridge, MA 02138 USA.
[Gire, Stephen K.; Winnicki, Sarah M.; Lin, Aaron E.; Sabeti, Pardis C.] Broad Inst MIT & Harvard, Cambridge, MA USA.
[Mele, Marta; Gerhardinger, Chiara; Rinn, John L.] Harvard Univ, Dept Stem Cell & Regenerat Biol, Cambridge, MA 02138 USA.
[Connor, John H.] Boston Univ, Sch Med, Dept Microbiol, Boston, MA 02118 USA.
RP Connor, JH (reprint author), Boston Univ, Sch Med, Dept Microbiol, Boston, MA 02118 USA.
EM jhconnor@bu.edu
OI Honko, Anna/0000-0001-9165-148X
FU USAMRAA Biomarkers [W81XWH-11-1-0141]; National Science Foundation [DGE
1144152]; National Institute of Allergy and Infectious Diseases,
National Institutes of Health, Department of Health and Human Services
[U19AI110818]; [W81XWH 100-02-0008]; [11-02-0130]
FX This work was supported by contracts W81XWH 100-02-0008, 11-02-0130, and
USAMRAA Biomarkers W81XWH-11-1-0141, and by a grant from the National
Science Foundation No. DGE 1144152 (AEL). This project has been funded
in part with Federal funds from the National Institute of Allergy and
Infectious Diseases, National Institutes of Health, Department of Health
and Human Services, under Grant Number U19AI110818 to the Broad
Institute. Marta Mele Messeguer is a Gilead Fellow of the Life Sciences
Research Foundation.
NR 53
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U1 2
U2 2
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2164
J9 BMC GENOMICS
JI BMC Genomics
PD SEP 5
PY 2016
VL 17
AR 707
DI 10.1186/s12864-016-3060-0
PG 13
WC Biotechnology & Applied Microbiology; Genetics & Heredity
SC Biotechnology & Applied Microbiology; Genetics & Heredity
GA DW2JR
UT WOS:000383469200003
PM 27595844
ER
PT J
AU Cheppudira, BP
Trevino, AV
Petz, LN
Christy, RJ
Clifford, JL
AF Cheppudira, Bopaiah P.
Trevino, Alex V.
Petz, Lawrence N.
Christy, Robert J.
Clifford, John L.
TI Anti-nerve growth factor antibody attenuates chronic morphine
treatment-induced tolerance in the rat
SO BMC ANESTHESIOLOGY
LA English
DT Article
DE Nerve growth factor; Anti-NGF; Morphine; Tolerance; Hargreaves' test
ID OPIOID TOLERANCE; PAIN; HYPERALGESIA; WITHDRAWAL; NEURONS; INJURY; NGF
AB Background: Nerve growth factor (NGF) is known to induce inflammation and pain; however its role in opioid-induced tolerance has not been studied. This study investigated the effects of an anti-NGF neutralizing antibody on the development of tolerance following chronic morphine treatment in naive rats.
Methods: Four groups of rats were used in this study; one treated with saline alone, one with 10 mg/kg of morphine, one with 10 mu g of anti-NGF and the other with 10 mg/kg of morphine + 10 mu g of anti-NGF, twice per day for 5 days. The route of treatment was subcutaneous (S.C.) for morphine and saline, and intraperitoneal (i.p.) for anti-NGF. Response to a noxious thermal stimulus during the course of drug treatment was assessed (Hargreaves' test). Further, the change in the NGF levels in the lumbar spinal cord was measured by ELISA.
Results: Our results showed that repeated administration of morphine produced an apparent tolerance which was significantly attenuated by co-administration of anti-NGF (P < 0.001). Additionally, the area under the curve (AUC) of the analgesic effect produced by the combination of morphine and anti-NGF was significantly (P < 0.001) greater than for saline controls and chronic morphine treated rats. Moreover, the level of NGF in the spinal cord of chronic morphine treated rats was significantly higher (P < 0.05) than in both the saline control group and the group receiving simultaneous administration of anti-NGF with morphine. These results indicate that anti-NGF has the potential to attenuate morphine-induced tolerance behavior by attenuating the effects of NGF at the spinal level.
Conclusion: Taken together, our study strongly suggests that the NGF signaling system is a potential novel target for treating opioid-induced tolerance.
C1 [Cheppudira, Bopaiah P.; Trevino, Alex V.; Christy, Robert J.; Clifford, John L.] US Army, Burn Injuries Task Area, Inst Surg Res, San Antonio Mil Med Ctr, 3698 Chambers Pass, San Antonio, TX 78234 USA.
[Petz, Lawrence N.] US Army, Dept Clin Invest, Inst Surg Res, San Antonio Mil Med Ctr, 3698 Chambers Pass, San Antonio, TX 78234 USA.
RP Cheppudira, BP (reprint author), US Army, Burn Injuries Task Area, Inst Surg Res, San Antonio Mil Med Ctr, 3698 Chambers Pass, San Antonio, TX 78234 USA.
EM bopaiah.p.cheppudira.vol@mail.mil
FU United States Army Medical Research and Materiel Command Combat
Causality Care Research program; Clinical and Rehabilitative Medicine
Research program; National Research Council (NRC) Senior Research
Associate Fellowship
FX This work is supported by the United States Army Medical Research and
Materiel Command Combat Causality Care Research and the Clinical and
Rehabilitative Medicine Research programs. B Cheppudira is supported by
the National Research Council (NRC) Senior Research Associate
Fellowship.
NR 23
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PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2253
J9 BMC ANESTHESIOL
JI BMC Anesthesiol.
PD SEP 5
PY 2016
VL 16
AR 73
DI 10.1186/s12871-016-0242-x
PG 6
WC Anesthesiology
SC Anesthesiology
GA DV7QB
UT WOS:000383130300001
PM 27596139
ER
PT J
AU Cazares, LH
Ward, MD
Brueggemann, EE
Kenny, T
Demond, P
Mahone, CR
Martins, KAO
Nuss, JE
Glaros, T
Bavari, S
AF Cazares, Lisa H.
Ward, Michael D.
Brueggemann, Ernst E.
Kenny, Tara
Demond, Paul
Mahone, Christopher R.
Martins, Karen A. O.
Nuss, Jonathan E.
Glaros, Trevor
Bavari, Sina
TI Development of a liquid chromatography high resolution mass spectrometry
method for the quantitation of viral envelope glycoprotein in Ebola
virus-like particle vaccine preparations
SO CLINICAL PROTEOMICS
LA English
DT Article
DE Ebola virus; Virus like particles; High resolution mass spectrometry;
Stable isotope dilution quantitation
ID PROTEIN QUANTITATION; FILOVIRUS VACCINE; DENDRITIC CELLS; DNA VACCINES;
PROTECTION; ANTIBODIES; INFECTION; GP; IMMUNOGENICITY; CHALLENGE
AB Background: Ebola virus like particles (EBOV VLPs, eVLPs), are produced by expressing the viral transmembrane glycoprotein (GP) and structural matrix protein VP40 in mammalian cells. When expressed, these proteins self-assemble and bud from 'host' cells displaying morphology similar to infectious virions. Several studies have shown that rodents and non-human primates vaccinated with eVLPs are protected from lethal EBOV challenge. The mucin-like domain of envelope glycoprotein GP(1) serves as the major target for a productive humoral immune response. Therefore GP(1) concentration is a critical quality attribute of EBOV vaccines and accurate measurement of the amount of GP(1) present in eVLP lots is crucial to understanding variability in vaccine efficacy.
Methods: After production, eVLPs are characterized by determining total protein concentration and by western blotting, which only provides semi-quantitative information for GP(1). Therefore, a liquid chromatography high resolution mass spectrometry (LC-HRMS) approach for accurately measuring GP(1) concentration in eVLPs was developed. The method employs an isotope dilution strategy using four target peptides from two regions of the GP(1) protein. Purified recombinant GP(1) was generated to serve as an assay standard. GP(1) quantitation in 5 eVLP lots was performed on an LTQ-Orbitrap Elite and the final quantitation was derived by comparing the relative response of 200 fmol AQUA peptide standards to the analyte response at 4 ppm.
Results: Conditions were optimized to ensure complete tryptic digestion of eVLP, however, persistent missed cleavages were observed in target peptides. Additionally, N-terminal truncated forms of the GP(1) protein were observed in all eVLP lots, making peptide selection crucial. The LC-HRMS strategy resulted in quantitation of GP(1) with a lower limit of quantitation of 1 fmol and an average percent coefficient of variation (CV) of 7.6 %. Unlike western blot values, the LC-HRMS quantitation of GP(1) in 5 eVLP vaccine lots exhibited a strong linear relationship (positive correlation) with survival (after EBOV challenge) in mice.
Conclusions: This method provides a means to rapidly determine eVLP batch quality based upon quantitation of antigenic GP(1). By monitoring variability in GP(1) content, the eVLP production process can be optimized, and the total amount of GP(1) needed to confer protection accurately determined.
C1 [Cazares, Lisa H.; Ward, Michael D.; Brueggemann, Ernst E.; Kenny, Tara; Mahone, Christopher R.; Martins, Karen A. O.; Nuss, Jonathan E.; Bavari, Sina] US Army, Mol & Translat Sci Div, Med Res Inst Infect Dis, Frederick, MD 21702 USA.
[Demond, Paul; Glaros, Trevor] Edgewood Chem Biol Ctr, Biodef Branch, BioSci Div, Gunpowder, MD 21010 USA.
[Cazares, Lisa H.] US Army, DOD Biotechnol High Performance Comp Software App, Telemed & Adv Technol Res Ctr, Med Res & Mat Command, Ft Detrick, MD 21702 USA.
[Demond, Paul] Excet Inc, 8001 Braddock Rd,Suite 105, Springfield, VA 22151 USA.
RP Cazares, LH (reprint author), US Army, Mol & Translat Sci Div, Med Res Inst Infect Dis, Frederick, MD 21702 USA.
EM lisa.h.cazares.ctr@mail.mil
FU United States Department of Defense [MCS.B13]
FX This study was supported the United States Department of Defense (Award
MCS.B13).
NR 37
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PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1542-6416
EI 1559-0275
J9 CLIN PROTEOM
JI Clin. Proteom.
PD SEP 5
PY 2016
VL 13
AR 18
DI 10.1186/s12014-016-9119-8
PG 18
WC Biochemical Research Methods
SC Biochemistry & Molecular Biology
GA DV4RO
UT WOS:000382913000001
PM 27597813
ER
PT J
AU Ciezak-Jenkins, JA
AF Ciezak-Jenkins, Jennifer A.
TI High-pressure polymorphism of the electrochemically active organic
molecule tetrahydroxy-p-benzoquinone
SO JOURNAL OF MOLECULAR STRUCTURE
LA English
DT Article
DE High-pressure; Diamond anvil cell; Spectroscopy
ID RHODIZONIC ACID; BIOLOGICAL PROCESSES; ELECTRON-TRANSPORT;
CHARGE-TRANSFER; HYDROGEN-BOND; NITRIC-ACID; BEHAVIOR; CRYSTAL;
FREQUENCIES; REDUCTONES
AB The structural and chemical response of tetrahydroxy-p-benzoquinone to isothermal compression to near 20 GPa have been studied using powder x-ray diffraction and vibrational spectroscopy. Compression beyond 11.5 GPa resulted in the appearance of several new peaks in the x-ray patterns, changes in the peak distribution and intensities, as well as the disappearance of features observed at lower pressures, which when coupled with concomitant changes in the infrared spectrum are indicative of a phase transition. Further analysis of the infrared spectra suggest this phase transition results in an increase in the anharmonicity of the system. Raman spectroscopic experiments indicate the high-pressure phase to be highly photosensitive and easily polymerized. Published by Elsevier B.V.
C1 [Ciezak-Jenkins, Jennifer A.] US Army, Res Lab, RDRL WML B, Aberdeen Proving Ground, MD 21005 USA.
RP Ciezak-Jenkins, JA (reprint author), US Army, Res Lab, RDRL WML B, Aberdeen Proving Ground, MD 21005 USA.
EM jennifer.a.ciezak-jenkins.civ@mail.mil
FU Office of Science, Office of Basic Energy Sciences of the U.S.
Department of Energy [DE-AC02-05CH11231]; DOE-NNSA [DE-NA0001974];
DOE-BES [DEFG02- 99ER45775]; NSF; U.S. Department of Energy, Office of
Science, Office of Basic Energy Sciences [DE-AC02-98CH10886]
FX The Advanced Light Source at Lawrence Berkeley National Laboratory is
thanked for access to the facility and Beamline 12.2.2. The Advanced
Light Source is supported by the Director, Office of Science, Office of
Basic Energy Sciences, of the U.S. Department of Energy under Contract
No. DE-AC02-05CH11231. Portions of this work was performed at HPCAT
(Sector 16), Advanced Photon Source (APS), Argonne National Laboratory
(ANL). HPCAT operations are supported by DOE-NNSA under Award No.
DE-NA0001974 and DOE-BES under Award No. DEFG02- 99ER45775, with partial
instrumentation funding by NSF. Use of the National Synchrotron Light
Source, Brookhaven National Laboratory, was supported by the U.S.
Department of Energy, Office of Science, Office of Basic Energy
Sciences, under Contract No. DE-AC02-98CH10886.
NR 36
TC 0
Z9 0
U1 7
U2 13
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0022-2860
EI 1872-8014
J9 J MOL STRUCT
JI J. Mol. Struct.
PD SEP 5
PY 2016
VL 1119
BP 71
EP 77
DI 10.1016/j.molstruc.2016.04.062
PG 7
WC Chemistry, Physical
SC Chemistry
GA DP2YR
UT WOS:000378360000009
ER
PT J
AU Lawrimore, WB
Paliwal, B
Chandler, MQ
Johnson, KL
Horstemeyer, MF
AF Lawrimore, W. B.
Paliwal, B.
Chandler, M. Q.
Johnson, K. L.
Horstemeyer, M. F.
TI Hierarchical multiscale modeling of Polyvinyl Alcohol/Montmorillonite
nanocomposites
SO POLYMER
LA English
DT Article
DE Multiscale modeling; Internal State Variable model; Finite element
analysis
ID LAYERED SILICATE NANOCOMPOSITES; AMORPHOUS GLASSY-POLYMERS; COHESIVE
ZONE LAW; MOLECULAR-DYNAMICS; STRAIN-RATES; INTERGRANULAR FRACTURE;
MECHANICAL-PROPERTIES; EPOXY NANOCOMPOSITES; BRITTLE MATERIALS;
LARGE-DEFORMATION
AB The mechanical responses of low volume fraction Polyvinyl Alcohol (PVA)/Montmorillonite (MMT) nanocomposites were modeled using a hierarchical multiscale modeling method. Nanoscale Molecular Dynamics (MD) and mesoscale Finite Element Analysis (FEA) were used to bridge information regarding deformation mechanics within Polymer/Clay Nanocomposites (PCNs). MD computations of PVA/MMT interfaces were employed to calibrate a Traction-Separation (T-S) relation, which was then upscaled into a cohesive zone model (CZM) to model interfaces between PVA and MMT in a mesomechanical finite element framework. Virtual Composite Structure Generation (VCSG) was used to generate a quasirealistic Representative Volume Element (RVE), and explicit FEA was performed on the RVE to demonstrate delamination in the PCNs. The FEA featured an elasto-viscoelastic-viscoplastic Internal State Variable (ISV) model for the polymer host (PVA) and a CZM for the interfaces between MMT and PVA. The hierarchical length scale bridging methodology employed here for a polymer based composite has applications for many other material systems. Published by Elsevier Ltd.
C1 [Lawrimore, W. B.; Paliwal, B.; Johnson, K. L.; Horstemeyer, M. F.] Mississippi State Univ, CAVS, Starkville, MS USA.
[Horstemeyer, M. F.] Mississippi State Univ, Dept Mech Engn, Starkville, MS USA.
[Chandler, M. Q.] ERDC, Vicksburg, MS USA.
RP Lawrimore, WB (reprint author), 200 Res Blvd, Starkville, MS 39759 USA.
EM wblawrimore@gmail.com
OI Horstemeyer, Mark/0000-0003-4230-0063
FU Center for Advanced Vehicular Systems (CAVS) at Mississippi State
University; U.S. Army Engineer Research and Development Center (ERDC)
[W912HZ-15-2-0004]; Center-Directed Research Program of US Army Engineer
Research and Development Center
FX Support from the Center for Advanced Vehicular Systems (CAVS) at
Mississippi State University is gratefully acknowledged. W. B. L., B.
P., K. L. J., and M. F. H. would also like to thank the U.S. Army
Engineer Research and Development Center (ERDC) under Cooperative
Agreement number W912HZ-15-2-0004. The work of M.Q.C. was supported by
the Center-Directed Research Program of US Army Engineer Research and
Development Center. The views and conclusions contained herein are those
of the authors and should not be interpreted as necessarily representing
the official policies or endorsements, either expressed or implied, of
the Engineering Research and Development Center or the U.S. Government.
Permission to publish was granted by the Director, ERDC Geotechnical and
Structures Laboratory.
NR 74
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U1 14
U2 14
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0032-3861
EI 1873-2291
J9 POLYMER
JI Polymer
PD SEP 2
PY 2016
VL 99
BP 386
EP 398
DI 10.1016/j.polymer.2016.07.026
PG 13
WC Polymer Science
SC Polymer Science
GA DW8DW
UT WOS:000383885000043
ER
PT J
AU Stacey, W
Bhave, S
Uht, RM
AF Stacey, Winfred
Bhave, Shreyas
Uht, Rosalie M.
TI Mechanisms by Which 17 beta-Estradiol (E2) Suppress Neuronal cox-2 Gene
Expression
SO PLOS ONE
LA English
DT Article
ID NF-KAPPA-B; ESTROGEN-RECEPTOR-ALPHA; HISTONE H4 ACETYLATION;
TRANSCRIPTIONAL REPRESSION; ALZHEIMERS-DISEASE; BETA; BRAIN;
CYCLOOXYGENASE-2; RECRUITMENT; PROMOTER
AB E2 attenuates inflammatory responses by suppressing expression of pro-inflammatory genes. Given that inflammation is increasingly being associated with neurodegenerative and psychiatric processes, we sought to elucidate mechanisms by which E2 down-regulates a component of an inflammatory response, cyclooxygenase-2 (COX-2) expression. Although inflammatory processes in the brain are usually associated with microglia and astrocytes, we found that the COX-2 gene (cox-2) was expressed in a neuronal context, specifically in an amygdalar cell line (AR-5). Given that COX-2 has been reported to be in neurons in the brain, and that the amygdala is a site involved in neurodegenerative and neuropsychiatric processes, we investigated mechanisms by which E2 could down-regulate cox-2 expression in the AR-5 line. These cells express estrogen receptors alpha (ER alpha) and beta (ER beta), and as shown here cox-2. At the level of RNA, E2 and the ER beta selective ligand diarylpropionitrile (DPN) both attenuated gene expression, whereas the ERa selective ligand propyl pyrazole triol (PPT) had no effect. Neither ligand increased ER beta at the cox-2 promoter. Rather, DPN decreased promoter occupancy of NF-kappa B p65 and histone 4 (H4) acetylation. Treatment with the non-specific HDAC inhibitor Trichostatin A (TSA) counteracted DPN's repressive effects on cox-2 expression. In keeping with the TSA effect, E2 and DPN increased histone deacetylase one (HDAC1) and switch-independent 3A (Sin3A) promoter occupancy. Lastly, even though E2 increased CpG methylation, DPN did not. Taken together, the pharmacological data indicate that ER beta contributes to neuronal cox-2 expression, as measured by RNA levels. Furthermore, ER ligands lead to increased recruitment of HDAC1, Sin3A and a concomitant reduction of p65 occupancy and Ac-H4 levels. None of the events, however, are associated with a significant recruitment of ER beta at the promoter. Thus, ER beta directs recruitment to the cox-2 promoter, but does so in the absence of being recruited itself.
C1 [Stacey, Winfred; Bhave, Shreyas; Uht, Rosalie M.] Univ North Texas Hlth Sci Ctr, Grad Sch Biomed Sci, Ft Worth, TX 76107 USA.
[Stacey, Winfred; Bhave, Shreyas; Uht, Rosalie M.] Univ North Texas Hlth Sci Ctr, Inst Hlth Aging, Ctr Alzheimers & Neurodegenerat Dis Res, Ft Worth, TX 76107 USA.
[Stacey, Winfred] US Army, Inst Surg Res, 3698 Chambers Pass,BHT 1, Jbsa Ft Sam Houston, TX 78234 USA.
RP Uht, RM (reprint author), Univ North Texas Hlth Sci Ctr, Grad Sch Biomed Sci, Ft Worth, TX 76107 USA.; Uht, RM (reprint author), Univ North Texas Hlth Sci Ctr, Inst Hlth Aging, Ctr Alzheimers & Neurodegenerat Dis Res, Ft Worth, TX 76107 USA.
EM rosalie.uht@unthsc.edu
FU National Institutes of Health [R01-MH082900]; RMU University of North
Texas Health Science Center; Doctoral Student Bridge Grant; Neurobiology
of Aging Predoctoral Training Grant
FX This work was supported by National Institutes of Health, R01-MH082900,
RMU University of North Texas Health Science Center, Doctoral Student
Bridge Grant, WS and Neurobiology of Aging Predoctoral Training Grant -
Associate Fellow, WS.
NR 57
TC 0
Z9 0
U1 2
U2 2
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 2
PY 2016
VL 11
IS 9
AR e0161430
DI 10.1371/journal.pone.0161430
PG 16
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA DV4EJ
UT WOS:000382877800008
PM 27588681
ER
PT J
AU Griffith, GL
Wirostko, BM
Lee, HK
Johnson, AL
Zamora, DO
AF Griffith, Gina L.
Wirostko, Barbara M.
Lee, Hee-Kyoung
Johnson, Anthony Lames
Zamora, David O.
TI Human growth hormone released from a biocompatible hyaluronic acid
biomaterial modulates wound healing in an in vivo corneal chemical burn
model
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
CT Annual Meeting of the
Association-for-Research-in-Vision-and-Ophthalmology (ARVO)
CY MAY 01-05, 2016
CL Seattle, WA
SP Assoc Res Vis & Ophthalmol
C1 [Griffith, Gina L.; Johnson, Anthony Lames; Zamora, David O.] US Army Inst Surg Res, Ocular Trauma, San Antonio, TX USA.
[Wirostko, Barbara M.; Lee, Hee-Kyoung] Jade Theraput Inc, Salt Lake City, UT USA.
[Wirostko, Barbara M.; Lee, Hee-Kyoung] Univ Utah, Moran Eye Ctr, Salt Lake City, UT USA.
[Johnson, Anthony Lames] San Antonio Mil Med Ctr, San Antonio, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ASSOC RESEARCH VISION OPHTHALMOLOGY INC
PI ROCKVILLE
PA 12300 TWINBROOK PARKWAY, ROCKVILLE, MD 20852-1606 USA
SN 0146-0404
EI 1552-5783
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD SEP
PY 2016
VL 57
IS 12
MA 1265
PG 2
WC Ophthalmology
SC Ophthalmology
GA EK8LA
UT WOS:000394174003194
ER
PT J
AU Kaini, R
Wang, HCH
AF Kaini, Ramesh
Wang, Heuy-Ching Hetty
TI Xeno-free defined conditions for differentiation of protein-induced
pluripotent stem cells towards retinal precursor cells
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
CT Annual Meeting of the
Association-for-Research-in-Vision-and-Ophthalmology (ARVO)
CY MAY 01-05, 2016
CL Seattle, WA
SP Assoc Res Vis & Ophthalmol
C1 [Kaini, Ramesh; Wang, Heuy-Ching Hetty] US Army, Inst Surg Rsrch, Ophthalmol, San Antonio, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ASSOC RESEARCH VISION OPHTHALMOLOGY INC
PI ROCKVILLE
PA 12300 TWINBROOK PARKWAY, ROCKVILLE, MD 20852-1606 USA
SN 0146-0404
EI 1552-5783
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD SEP
PY 2016
VL 57
IS 12
MA 1130
PG 2
WC Ophthalmology
SC Ophthalmology
GA EK8LA
UT WOS:000394174003063
ER
PT J
AU Rios, JD
Choi, JH
McDaniel, J
Lund, B
AF Rios, J. David
Choi, Jae-Hyek
McDaniel, Jennifer
Lund, Brian
TI Acute ocular edema in survivable primary blast induced ocular injury in
rabbits
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
CT Annual Meeting of the
Association-for-Research-in-Vision-and-Ophthalmology (ARVO)
CY MAY 01-05, 2016
CL Seattle, WA
SP Assoc Res Vis & Ophthalmol
C1 [Rios, J. David; McDaniel, Jennifer; Lund, Brian] US Army Inst Surg Res, Ocular Trauma Res Task Area, San Antonio, TX USA.
[Choi, Jae-Hyek] US Army Inst Surg Res, Multi Organ Support Task Area, JBSA Ft Sam Houston, San Antonio, TX USA.
FU Department of Defense [W81XWH-12-2-0055]
FX Support Department of Defense Vision Research Program, Award Number
W81XWH-12-2-0055
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ASSOC RESEARCH VISION OPHTHALMOLOGY INC
PI ROCKVILLE
PA 12300 TWINBROOK PARKWAY, ROCKVILLE, MD 20852-1606 USA
SN 0146-0404
EI 1552-5783
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD SEP
PY 2016
VL 57
IS 12
MA 740
PG 2
WC Ophthalmology
SC Ophthalmology
GA EK8LA
UT WOS:000394174002160
ER
PT J
AU Parlin, A
Oliver, J
Steigleman, W
April, MD
AF Parlin, Andrew
Oliver, Josh
Steigleman, Walter
April, Michael D.
TI Ophthalmology in the Emergency Department: A survey of Emergency
Medicine Residents
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
CT Annual Meeting of the
Association-for-Research-in-Vision-and-Ophthalmology (ARVO)
CY MAY 01-05, 2016
CL Seattle, WA
SP Assoc Res Vis & Ophthalmol
C1 [Parlin, Andrew; Steigleman, Walter] Brooke Army Med Ctr, Ophthalmol, San Antonio, TX USA.
[Oliver, Josh; April, Michael D.] Brooke Army Med Ctr, Dept Emergency Med, San Antonio, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ASSOC RESEARCH VISION OPHTHALMOLOGY INC
PI ROCKVILLE
PA 12300 TWINBROOK PARKWAY, ROCKVILLE, MD 20852-1606 USA
SN 0146-0404
EI 1552-5783
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD SEP
PY 2016
VL 57
IS 12
MA 5548
PG 2
WC Ophthalmology
SC Ophthalmology
GA EK8YM
UT WOS:000394210601220
ER
PT J
AU Zhu, YL
Elliott, W
Edsall, P
Akers, A
Mendoza, D
Morris, R
Cleland, J
AF Zhu, Yanli
Elliott, William
Edsall, Peter
Akers, Andre
Mendoza, Danilo
Morris, Ryan
Cleland, Jeffery
TI Characterization of visual function and structure of the rat eye using
visual evoked potentials, pupil light reflex and spectral-domain optical
coherence tomography
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Meeting Abstract
CT Annual Meeting of the
Association-for-Research-in-Vision-and-Ophthalmology (ARVO)
CY MAY 01-05, 2016
CL Seattle, WA
SP Assoc Res Vis & Ophthalmol
C1 [Zhu, Yanli; Elliott, William; Edsall, Peter; Akers, Andre; Mendoza, Danilo; Morris, Ryan; Cleland, Jeffery] US Army Inst Surg Res, Ocular Trauma & Vis Restorat, Ft Sam Houston, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ASSOC RESEARCH VISION OPHTHALMOLOGY INC
PI ROCKVILLE
PA 12300 TWINBROOK PARKWAY, ROCKVILLE, MD 20852-1606 USA
SN 0146-0404
EI 1552-5783
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD SEP
PY 2016
VL 57
IS 12
MA 5761
PG 3
WC Ophthalmology
SC Ophthalmology
GA EK8YM
UT WOS:000394210602004
ER
PT J
AU Tagge, I
Schwartz, D
Powers, K
Bakshi, R
Calabresi, P
Constable, T
Grinstead, J
Henry, R
Nair, G
Oh, J
Papinutto, N
Pelletier, D
Reich, DS
Sicotte, N
Simon, J
Stern, W
Rooney, W
AF Tagge, I.
Schwartz, D.
Powers, K.
Bakshi, R.
Calabresi, P.
Constable, T.
Grinstead, J.
Henry, R.
Nair, G.
Oh, J.
Papinutto, N.
Pelletier, D.
Reich, D. S.
Sicotte, N.
Simon, J.
Stern, W.
Rooney, W.
TI Toward a standardized quantitative imaging protocol for multiple
sclerosis: a NAIMS multisite study of magnetization transfer and
quantitative T1 imaging techniques
SO MULTIPLE SCLEROSIS JOURNAL
LA English
DT Meeting Abstract
CT 32nd Congress of the
European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis
(ECTRIMS)
CY SEP 14-17, 2016
CL London, ENGLAND
SP European Comm Treatment & Res Multiple Sclerosis
C1 [Tagge, I.; Schwartz, D.; Powers, K.; Grinstead, J.; Simon, J.; Rooney, W.] Oregon Hlth & Sci Univ, Portland, OR 97201 USA.
[Bakshi, R.] Harvard Med Sch, Brigham & Womens Hosp, Brookline, MA USA.
[Calabresi, P.; Oh, J.] Johns Hopkins, Baltimore, MD USA.
[Constable, T.] Yale, New Haven, CT USA.
[Grinstead, J.] USA, Siemens Med Solut, Portland, OR USA.
[Henry, R.; Papinutto, N.; Stern, W.] Univ Calif San Francisco, San Francisco, CA 94143 USA.
[Nair, G.; Reich, D. S.] NINDS, NIH, Bldg 36,Rm 4D04, Bethesda, MD 20892 USA.
[Oh, J.] Univ Toronto, Toronto, ON, Canada.
[Pelletier, D.; Sicotte, N.] Univ Southern Calif, Keck Sch Med, Los Angeles, CA USA.
FU Race to Erase MS Fund; NINDS; AbbVie; EMD Serono; Genentech; Novartis;
Biogen; EMD-Serono; Sanofi-Genzyme; NIH [R01 NS082347]; MedImmune;
Multiple Sclerosis Society of Canada; Biogen-Idec; Genzyme; Teva; Roche;
Myelin Repair Foundation; Vertex Pharmaceuticals; National MS Society;
Guthy-Jackson Charitable Foundation
FX Ian Tagge is funded by the Race to Erase MS Fund and NINDS and has
nothing to disclose.; Rohit Bakshi is funded by the Race to Erase MS
Fund and has received consulting fees from AbbVie, EMD Serono,
Genentech, and Novartis, received research support from Biogen,
EMD-Serono, Novartis, and Sanofi-Genzyme, and serves as Editor-in-Chief
of the Journal of Neuroimaging.; Peter Calabresi is funded by NIH R01
NS082347 - Imaging neurodegeneration in multiple sclerosis, and has
received grants to Johns Hopkins from Biogen, Novartis, and MedImmune,
and has received honoraria for consulting from Vertex.; Roland Henry
recieves funding from NIH, DOD, and Roche/Genentech, and nothing to
disclose.; Jiwon Oh has received research funding from Multiple
Sclerosis Society of Canada, Sanofi-Genzyme, and Biogen-Idec, and has
received fees for consulting or speaking from EMD-Serono, Genzyme,
Biogen-Idec, Novartis, Teva, and Roche.; Daniel S. Reich recieves
research funding from Intramural Research Program of NINDS, Myelin
Repair Foundation, and Vertex Pharmaceuticals and has nothing to
disclose.; Nancy Sicotte recieves funding from National MS Society and
Guthy-Jackson Charitable Foundation and has nothing to disclose.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1352-4585
EI 1477-0970
J9 MULT SCLER J
JI Mult. Scler. J.
PD SEP
PY 2016
VL 22
SU 3
MA P1036
BP 530
EP 531
PG 2
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA DV9NJ
UT WOS:000383267202237
ER
PT J
AU Schwartz, DL
Tagge, I
Bakshi, R
Nair, G
Calabresi, P
Grinstead, J
Henry, R
Oh, J
Papinutto, N
Constable, T
Stern, W
Simon, J
Pelletier, D
Reich, DS
Sicotte, N
Rooney, W
AF Schwartz, D. L.
Tagge, I.
Bakshi, R.
Nair, G.
Calabresi, P.
Grinstead, J.
Henry, R.
Oh, J.
Papinutto, N.
Constable, T.
Stern, W.
Simon, J.
Pelletier, D.
Reich, D. S.
Sicotte, N.
Rooney, W.
TI Toward a standardized quantitative imaging protocol for multiple
sclerosis: inter- and intra-site variability in multiband rsfMRI
measurements acquired by NAIMS
SO MULTIPLE SCLEROSIS JOURNAL
LA English
DT Meeting Abstract
CT 32nd Congress of the
European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis
(ECTRIMS)
CY SEP 14-17, 2016
CL London, ENGLAND
SP European Comm Treatment & Res Multiple Sclerosis
C1 [Schwartz, D. L.; Tagge, I.; Simon, J.; Rooney, W.] OHSU, Portland, OR USA.
[Bakshi, R.] Harvard Med Sch, Boston, MA USA.
[Nair, G.; Reich, D. S.] NINDS, NIH, Bldg 36,Rm 4D04, Bethesda, MD 20892 USA.
[Calabresi, P.] Johns Hopkins Univ, Baltimore, MD USA.
[Grinstead, J.] USA, Siemens Med Solut, Portland, OR USA.
[Henry, R.; Papinutto, N.] UCSF, San Francisco, CA USA.
[Oh, J.] Univ Toronto, Toronto, ON, Canada.
[Constable, T.] Yale, New Haven, CT USA.
[Pelletier, D.; Sicotte, N.] Univ Southern Calif, Keck Sch Med, Los Angeles, CA USA.
FU Race to Erase MS Fund; AbbVie; EMD Serono; Genentech; Novartis; Biogen;
EMD-Serono; Sanofi-Genzyme; NINDS; NIH [R01 NS082347]; MedImmune; NIH;
DOD; Roche/Genentech; Multiple Sclerosis Society of Canada; Biogen-Idec;
Genzyme; Teva; Roche; Myelin Repair Foundation; Vertex Pharmaceuticals;
National MS Society; Guthy-Jackson Charitable Foundation
FX Daniel Schwartz is funded by Race to Erase MS Fund and has nothing to
disclose.; Rohit Bakshi is funded by the Race to Erase MS Fund and has
received consulting fees from AbbVie, EMD Serono, Genentech, and
Novartis, received research support from Biogen, EMD-Serono, Novartis,
and Sanofi-Genzyme, and serves as Editor-in-Chief of the Journal of
Neuroimaging.; Govind Nair is funded by Intramural Research Program,
NINDS and has nothing to disclose.; Peter Calabresi is funded by NIH R01
NS082347 - Imaging neurodegeneration in multiple sclerosis, and has
received grants to Johns Hopkins from Biogen, Novartis, and MedImmune,
and has received honoraria for consulting from Vertex.; Roland Henry
receives funding from NIH, DOD, and Roche/Genentech, and nothing to
disclose.; Jiwon Oh has received research funding from Multiple
Sclerosis Society of Canada, Sanofi-Genzyme, and Biogen-Idec, and has
received fees for consulting or speaking from EMD-Serono, Genzyme,
Biogen-Idec, Novartis, Teva, and Roche.; Daniel S. Reich receives
research funding from Intramural Research Program of NINDS, Myelin
Repair Foundation, and Vertex Pharmaceuticals and has nothing to
disclose.; Nancy Sicotte receives funding from National MS Society and
Guthy-Jackson Charitable Foundation and has nothing to disclose.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1352-4585
EI 1477-0970
J9 MULT SCLER J
JI Mult. Scler. J.
PD SEP
PY 2016
VL 22
SU 3
MA P1061
BP 546
EP 547
PG 2
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA DV9NJ
UT WOS:000383267202262
ER
PT J
AU Haufler, AJ
Starkey-El, JA
Davila, M
Fernan, P
Gavrilis, J
Kelleher, J
Lapsansky, B
Lewis, G
McDaniel, W
O'Brien, K
Southern, M
Westhelle, F
AF Haufler, Amy J.
Starkey-El, Jaime Arribas
Davila, Maria
Fernan, Paul
Gavrilis, James
Kelleher, Joseph
Lapsansky, Bradford
Lewis, Gregory
McDaniel, William
O'Brien, Kelly
Southern, Morgan
Westhelle, Felipe
TI ASSESSING SOLDIER ADAPTABILITY: DECISION MAKING TO AUTHENTIC CHALLENGE
SO PSYCHOPHYSIOLOGY
LA English
DT Meeting Abstract
C1 [Haufler, Amy J.; Starkey-El, Jaime Arribas; Fernan, Paul; Gavrilis, James; Kelleher, Joseph; Lapsansky, Bradford; McDaniel, William; O'Brien, Kelly; Westhelle, Felipe] Johns Hopkins Univ, Baltimore, MD 21218 USA.
[Davila, Maria; Lewis, Gregory] Univ N Carolina, Chapel Hill, NC USA.
[Southern, Morgan] US Army, Asymmetr Warfare Grp, Ft George G Meade, MD USA.
FU Asymmetric Warfare Group, U.S. Army
FX Funding for this project was provided by the Asymmetric Warfare Group,
U.S. Army.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0048-5772
EI 1469-8986
J9 PSYCHOPHYSIOLOGY
JI Psychophysiology
PD SEP
PY 2016
VL 53
SU 1
SI SI
BP S24
EP S24
PG 1
WC Psychology, Biological; Neurosciences; Physiology; Psychology;
Psychology, Experimental
SC Psychology; Neurosciences & Neurology; Physiology
GA EK1FX
UT WOS:000393672300093
ER
PT J
AU Burdette, AJ
Paredes, RM
Crossland, RF
Macko, AR
Aden, J
Sheppard, FR
AF Burdette, Alexander J.
Paredes, Ruth Madelaine
Crossland, Randy F.
Macko, Antoni R.
Aden, James
Sheppard, Forest R.
TI INFLAMMATORY PROFILE IN RESPONSE TO UNCONTROLLED HEMORRHAGE IN A
NON-HUMAN PRIMATE (RHESUS MACAQUE) MODEL
SO SHOCK
LA English
DT Article
DE Chemokines; cytokines; hemorrhagic shock; immune response; trauma
ID MULTIPLE ORGAN FAILURE; ANIMAL-MODELS; SHOCK; TRAUMA; INJURY;
EPIDEMIOLOGY; PATTERNS; DISEASE; SEPSIS; LIGAND
AB Background: Uncontrolled hemorrhage (UH), the leading cause of potentially survivable combat-related death, elicits a deleterious inflammatory response. Our group previously reported an increased secretion of pro-inflammatory cytokines in a novel non-human primate model of UH; however, to better understand the molecular profile of the inflammatory response to UH, we performed a comprehensive evaluation of inflammation at the proteomic and transcriptomic level. Methods: Anesthetized rhesus macaques (n = 8) underwent UH by 60% left lobe hepatectomy T = 0 min. At T = 5 min, animals received 11mL of 5% albumin followed by normal saline infusion to a total resuscitation volume of 20 mL/kg by T = 120 min. Blood (T = 0, 5, 20, 120, 480 min) was collected for qPCR and multiplex cytokine quantification. Results from each non-human primate (NHP) per time-point are shown. Statistical analysis by one-way ANOVA with repeated measures, P<0.05 was considered significant. Results: Luminex analysis in serum revealed significant upregulation compared with baseline of 8 cytokines/chemokines starting T = 120 min postinjury and significant down-regulation of 4 cytokines/chemokines as early as T = 20 min postinjury. Gene expression analysis in white blood cells uncovered 10 genes that were up-regulated greater than 3-fold compared with baseline and 29 genes that were down-regulated greater than 3-fold. Conclusion: The present study confirms the presence of systemic inflammation after UH at the proteomic and transcriptomic level providing insight into the inflammatory mediators that are involved as well as their kinetics following UH. The data demonstrates that NHP hemorrhage models may be suitable for evaluating therapeutics to control inflammation following hemorrhage.
C1 [Burdette, Alexander J.; Paredes, Ruth Madelaine; Crossland, Randy F.; Macko, Antoni R.; Sheppard, Forest R.] Naval Med Res Unit San Antonio, Dept Expeditionary & Trauma Med, 3650 Chambers Pass,Bldg 3160, Jbsa Ft Sam Houston, TX 78234 USA.
[Aden, James] US Army Inst Surg Res, Dept Stat & Epidemiol, Jbsa Ft Sam Houston, TX USA.
RP Sheppard, FR (reprint author), Naval Med Res Unit San Antonio, Dept Expeditionary & Trauma Med, 3650 Chambers Pass,Bldg 3160, Jbsa Ft Sam Houston, TX 78234 USA.
EM forest.r.sheppard.mil@mail.mil
NR 34
TC 1
Z9 1
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1073-2322
EI 1540-0514
J9 SHOCK
JI Shock
PD SEP
PY 2016
VL 46
IS 3
SU 1
BP 115
EP 122
DI 10.1097/SHK.0000000000000638
PG 8
WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease
SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System
& Cardiology
GA DX3HG
UT WOS:000384263600017
PM 27172162
ER
PT J
AU House, J
AF House, Jonathan
TI Leningrad: State of Siege
SO JOURNAL OF COLD WAR STUDIES
LA English
DT Book Review
C1 [House, Jonathan] US Army Command & Gen Staff Coll, Ft Leavenworth, KS 66027 USA.
RP House, J (reprint author), US Army Command & Gen Staff Coll, Ft Leavenworth, KS 66027 USA.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU MIT PRESS
PI CAMBRIDGE
PA ONE ROGERS ST, CAMBRIDGE, MA 02142-1209 USA
SN 1520-3972
EI 1531-3298
J9 J COLD WAR STUD
JI J. Cold War Stud.
PD FAL
PY 2016
VL 18
IS 4
BP 223
EP 225
PG 4
WC History; International Relations; Political Science
SC History; International Relations; Government & Law
GA EJ3JH
UT WOS:000393107900017
ER
PT J
AU Thomas, TA
Gentzler, K
Salvatorelli, R
AF Thomas, Ted A. h
Gentzler, Kevin
Salvatorelli, Robert
TI WHAT IS TOXIC FOLLOWERSHIP?
SO Journal of Leadership Studies
LA English
DT Article
AB There has been some discussion on the subject of toxic followership, but it is as yet ill-defined and deserves further evaluation and study. The current paper examines toxic followership using Kelley's typology of followers and provides potential methods of mitigating toxic followership. Just as toxic leaders harm organizations, so too can toxic followers. They both can cause good people to leave an organization, and put the organization's survival at risk.
C1 [Thomas, Ted A. h] Command & Gen Staff Coll, Dept Command & Leadership, Ft Leavenworth, KS 66027 USA.
[Gentzler, Kevin; Salvatorelli, Robert] US Army, Command & Gen Staff Coll, Ft Leavenworth, KS USA.
[Gentzler, Kevin] 15th Finance Battal, Ft Hood, TX USA.
[Gentzler, Kevin] 15th Finance Battal, Baghdad, Iraq.
[Gentzler, Kevin] Univ Phoenix, Dissertat & Doctoral Studies Management, Tempe, AZ USA.
RP Thomas, TA (reprint author), Command & Gen Staff Coll, Dept Command & Leadership, Ft Leavenworth, KS 66027 USA.
EM ted.a.thomas.civ@mail.mil; kevin.e.gentzler.civ@mail.mil;
robert.l.salvatorelli.civ@mail.mil
NR 14
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1935-2611
EI 1935-262X
J9 J LEADERSH STUD
JI J. Leadersh. Stud.
PD FAL
PY 2016
VL 10
IS 3
BP 62
EP 65
DI 10.1002/jls.21496
PG 4
WC Management
SC Business & Economics
GA EI9PY
UT WOS:000392842200009
ER
PT J
AU Singh, J
Johnson, RC
Schlett, CD
Elassal, EM
Crawford, KB
Mor, D
Lanier, JB
Law, NN
Walters, WA
Teneza-Mora, N
Bennett, JW
Hall, ER
Millar, EV
Ellis, MW
Merrell, DS
AF Singh, Jatinder
Johnson, Ryan C.
Schlett, Carey D.
Elassal, Emad M.
Crawford, Katrina B.
Mor, Deepika
Lanier, Jeffrey B.
Law, Natasha N.
Walters, William A.
Teneza-Mora, Nimfa
Bennett, Jason W.
Hall, Eric R.
Millar, Eugene V.
Ellis, Michael W.
Merrell, D. Scott
TI Multi-Body-Site Microbiome and Culture Profiling of Military Trainees
Suffering from Skin and Soft Tissue Infections at Fort Benning, Georgia
SO MSPHERE
LA English
DT Article
DE MRSA; microbiome; SSTI; Staphylococcus aureus; USA300
ID RESISTANT STAPHYLOCOCCUS-AUREUS; METHICILLIN-RESISTANT; NASAL CARRIAGE;
STREPTOCOCCUS-PNEUMONIAE; UNITED-STATES; SEQUENCE DATA; RISK-FACTORS;
COLONIZATION; EPIDEMIOLOGY; PREVALENCE
AB Skin and soft tissue infections (SSTIs) are common in the general population, with increased prevalence among military trainees. Previous research has revealed numerous nasal microbial signatures that correlate with SSTI development and Staphylococcus aureus colonization. Thus, we hypothesized that the ecology of the inguinal, oropharynx, and perianal regions may also be altered in response to SSTI and/or S. aureus colonization. We collected body site samples from 46 military trainees with purulent abscess (SSTI group) as well as from 66 asymptomatic controls (non-SSTI group). We also collected abscess cavity samples to assess the microbial composition of these infections. Samples were analyzed by culture, and the microbial communities were characterized by high-throughput sequencing. We found that the nasal, inguinal, and perianal regions were similar in microbial composition and significantly differed from the oropharynx. We also observed differences in Anaerococcus and Streptococcus abundance between the SSTI and non-SSTI groups for the nasal and oropharyngeal regions, respectively. Furthermore, we detected community membership differences between the SSTI and non-SSTI groups for the nasal and inguinal sites. Compared to that of the other regions, the microbial compositions of the nares of S. aureus carriers and noncarriers were dramatically different; we noted an inverse correlation between the presence of Corynebacterium and the presence of Staphylococcus in the nares. This correlation was also observed for the inguinal region. Culture analysis revealed elevated methicillin-resistant S. aureus (MRSA) colonization levels for the SSTI group in the nasal and inguinal body sites. Together, these data suggest significant microbial variability in patients with SSTI as well as between S. aureus carriers and noncarriers.
IMPORTANCE While it is evident that nasal colonization with S. aureus increases the likelihood of SSTI, there is a significant lack of information regarding the contribution of extranasal colonization to the overall risk of a subsequent SSTI. Furthermore, the impact of S. aureus colonization on bacterial community composition outside the nasal microbiota is unclear. Thus, this report represents the first investigation that utilized both culture and high-throughput sequencing techniques to analyze microbial dysbiosis at multiple body sites of healthy and diseased/colonized individuals. The results described here may be useful in the design of future methodologies to treat and prevent SSTIs.
C1 [Singh, Jatinder; Johnson, Ryan C.; Merrell, D. Scott] Uniformed Serv Univ Hlth Sci, Dept Microbiol & Immunol, Bethesda, MD 20814 USA.
[Schlett, Carey D.; Elassal, Emad M.; Crawford, Katrina B.; Mor, Deepika; Law, Natasha N.; Millar, Eugene V.] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Dept Prevent Med & Biostat, Bethesda, MD 20814 USA.
[Schlett, Carey D.; Elassal, Emad M.; Crawford, Katrina B.; Mor, Deepika; Law, Natasha N.; Millar, Eugene V.] Henry M Jackson Fdn Adv Mil Med, Rockville, MD USA.
[Bennett, Jason W.; Merrell, D. Scott] Uniformed Serv Univ Hlth Sci, Dept Med, Room A3060, Bethesda, MD 20814 USA.
[Lanier, Jeffrey B.; Law, Natasha N.] Martin Army Community Hosp, Ft Benning, GA USA.
[Walters, William A.] Max Planck Inst Dev Biol, Dept Microbiome Sci, Tubingen, Germany.
[Teneza-Mora, Nimfa; Hall, Eric R.] Naval Med Res Ctr, Infect Dis Directorate, Wound Infect Dept, Silver Spring, MD USA.
[Bennett, Jason W.] Walter Reed Army Inst Res, Silver Spring, MD USA.
[Ellis, Michael W.] Univ Toledo, Med Ctr, 2801 W Bancroft St, Toledo, OH 43606 USA.
EM douglas.merrell@usuhs.edu
FU U.S. Department of Defense Program project grant [HT9404-12-1-0019];
Department of Defense Global Emerging Infections Surveillance and
Response System (GEIS) [HU0001-10-1-0018]; Military Infectious Diseases
Research Program (MIDRP) [HT9404-12-1-0012, HT9404-12-1-0021]; National
Institute of Allergy and Infectious Diseases, National Institutes of
Health (NIH) [Y1-AI-5072]
FX Primary support for this work was provided by a U.S. Department of
Defense Program project grant (HT9404-12-1-0019 to D.S.M., M.W.E., and
E.R.H.). Additional support for this work was provided by the Department
of Defense Global Emerging Infections Surveillance and Response System
(GEIS; HU0001-10-1-0018 to M.W.E.) and the Military Infectious Diseases
Research Program (MIDRP; HT9404-12-1-0012 to M.W.E. and HT9404-12-1-0021
to E.R.H.). The protocol was executed by the Infectious Disease Clinical
Research Program (IDCRP), a Department of Defense (DoD) program executed
through the Uniformed Services University of the Health Sciences, and
funded in part by the National Institute of Allergy and Infectious
Diseases, National Institutes of Health (NIH), under Inter-Agency
Agreement (Y1-AI-5072).
NR 54
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PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 2379-5042
J9 MSPHERE
JI mSphere
PD SEP-OCT
PY 2016
VL 1
IS 5
AR e00232-16
DI 10.1128/mSphere.00232-16
PG 18
WC Microbiology
SC Microbiology
GA EI6EC
UT WOS:000392586800012
ER
PT J
AU Butkus, MA
Riegner, DE
AF Butkus, Michael A.
Riegner, Dawn E.
TI Lead stabilization by Polonite and phosphate amended Polonite: Modeling
SO JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
LA English
DT Article
DE Immobilization; Surface complexation chemical equilibrium; Freundlich;
Hill; Isotherm; Water
ID WASTE-WATER TREATMENT; RAY-ABSORPTION SPECTROSCOPY; ACTIVATED CARBON;
HEAVY-METALS; SOIL; REMOVAL; IMMOBILIZATION; PHOSPHORUS; ADSORPTION;
PB(II)
AB Polonite is an alkaline material that is used to remove nutrients from domestic wastewater and it has been evaluated as a fertilizer. Stabilization of Pb by Polonite and Polonite amended with orthophosphate, PO4, (Polonite-P) was evaluated and modeled with isotherm and chemical equilibrium models. Uptake of Pb at low Pb loading for each sorbent (sorbate to sorbent mass ratios of less than 0.6 mg Pb/g Polonite and less than 4 mg Pb/g Polonite-P) was best-fit with the Freundlich isotherm model. Lead sorption by Polonite, at high Pb loading, was best-fit with the Freundlich isotherm model and Pb sorption by Polonite-P, at high Pb loading, was best-fit with the Hill isotherm model. The Polonite chemical equilibrium model predicted that the primary form of Pb above pH 7.5 was comprised of Pb-oxides. The Polonite-P chemical equilibrium model predicted that Pb formed a stabilized solid over a wider pH range than Polonite and the percentage of solid Pb4O(PO4)(2) increased with increasing initial Pb loading above approximately 65 mg Pb/L. The Polonite and Polonite-P models have been used to develop a framework that can aid in design of Pb remediation systems and they can serve as a foundation for more complex models in natural and engineered systems. Published by Elsevier Ltd.
C1 [Butkus, Michael A.] US Mil Acad, Dept Geog & Environm Engn, Environm Engn Program, West Point, NY 10996 USA.
[Riegner, Dawn E.] US Mil Acad, Dept Chem & Life Sci, Chem Program, West Point, NY 10996 USA.
RP Butkus, MA (reprint author), US Mil Acad, Dept Geog & Environm Engn, Environm Engn Program, West Point, NY 10996 USA.
EM Michael.Butkus@usma.edu
FU US Army Research Laboratory
FX The technical assistance of Mr. Anand Shetty, Department of Geography
and Environmental Engineering, United States Military Academy is greatly
appreciated. This project was supported by a grant from the US Army
Research Laboratory. Although the research presented in this paper has
been undertaken by personnel employed by US Military Academy, it does
not necessarily reflect the views of the Academy or the US Army.
NR 49
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U1 4
U2 4
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 2213-3437
J9 J ENVIRON CHEM ENG
JI J. Environ. Chem. Eng.
PD SEP
PY 2016
VL 4
IS 3
BP 3562
EP 3569
DI 10.1016/j.jece.2016.07.022
PG 8
WC Engineering, Environmental
SC Engineering
GA EH3UV
UT WOS:000391698400104
ER
PT J
AU Gingrich, E
Janecek, D
Ghandhi, J
AF Gingrich, Eric
Janecek, Daniel
Ghandhi, Jaal
TI Experimental Investigation of the Impact of In-Cylinder Pressure
Oscillations on Piston Heat Transfer
SO SAE INTERNATIONAL JOURNAL OF ENGINES
LA English
DT Article
AB An experimental investigation was conducted to explore the impact in-cylinder pressure oscillations have on piston heat transfer. Two fast-response surface thermocouples embedded in the piston top measured transient temperature and a commercial wireless telemetry system was used to transmit thermocouple signals from the moving piston. Measurements were made in a light-duty single-cylinder research engine operated under low temperature combustion regimes including Homogeneous Charge Compression Ignition (HCCI) and Reactivity Controlled Compression Ignition (RCCI) and Conventional Diesel (CDC). The HCCI data showed a correlated trend of higher heat transfer with increased pressure oscillation strength, while the RCCI and CDC data did not. An extensive HCCI data set was acquired. The heat transfer rate - when corrected for differences in cylinder pressure and gas temperature - was found to positively correlate with increased pressure oscillations. It is important to normalize the data before drawing conclusions as the magnitude of the effect was diminished significantly by the normalization procedure.
C1 [Gingrich, Eric] US Army TARDEC, Warren, MI 48397 USA.
[Janecek, Daniel; Ghandhi, Jaal] Univ Wisconsin, Engine Res Ctr, Madison, WI 53706 USA.
RP Gingrich, E (reprint author), US Army TARDEC, Warren, MI 48397 USA.
EM eric.m.gingrich.civ@mail.mil; janecek@wisc.edu; ghandhi@engr.wisc.edu
FU Direct-injection Engine Research Consortium (DERC) member companies;
Office of Naval Research (ONR)
FX The authors would like to thank Yizhou Zhang, Adam Dempsey, and Ryan
Walker for the help they provided in acquiring engine data. Financial
support was provided by the Direct-injection Engine Research Consortium
(DERC) member companies and the Office of Naval Research (ONR).
NR 34
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U1 0
U2 0
PU SAE INT
PI WARRENDALE
PA 400 COMMONWEALTH DR, WARRENDALE, PA 15096 USA
SN 1946-3936
EI 1946-3944
J9 SAE INT J ENGINES
JI SAE Int. J. Engines
PD SEP
PY 2016
VL 9
IS 3
BP 1958
EP 1969
DI 10.4271/2016-01-9044
PG 12
WC Transportation Science & Technology
SC Transportation
GA EF8RD
UT WOS:000390595900053
ER
PT J
AU Lim, RB
AF Lim, Robert B.
TI Paired editorial: Does sleeve gastrectomy improve the gait parameters of
obese patients?
SO SURGERY FOR OBESITY AND RELATED DISEASES
LA English
DT Editorial Material
C1 [Lim, Robert B.] Tripler Army Med Ctr, Dept Surg, Honolulu, HI 96859 USA.
RP Lim, RB (reprint author), Tripler Army Med Ctr, Dept Surg, Honolulu, HI 96859 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1550-7289
EI 1878-7533
J9 SURG OBES RELAT DIS
JI Surg. Obes. Relat. Dis.
PD SEP-OCT
PY 2016
VL 12
IS 8
BP 1482
EP 1482
PG 1
WC Surgery
SC Surgery
GA EE8IR
UT WOS:000389869400007
PM 27425835
ER
PT J
AU Faler, B
AF Faler, Byron
TI Comment on: trends of bariatric surgery in France during the last ten
years. Analysis of 267,466 procedures from 2005 to 2014
SO SURGERY FOR OBESITY AND RELATED DISEASES
LA English
DT Editorial Material
C1 [Faler, Byron] Dwight D Eisenhower Army Med Ctr, Gen Surg, Ft Gordon, GA 30905 USA.
RP Faler, B (reprint author), Dwight D Eisenhower Army Med Ctr, Gen Surg, Ft Gordon, GA 30905 USA.
NR 5
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U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1550-7289
EI 1878-7533
J9 SURG OBES RELAT DIS
JI Surg. Obes. Relat. Dis.
PD SEP-OCT
PY 2016
VL 12
IS 8
BP 1609
EP 1610
PG 2
WC Surgery
SC Surgery
GA EE8IR
UT WOS:000389869400029
ER
PT J
AU MacCalman, AD
Beery, PT
Paulo, EP
AF MacCalman, Alex D.
Beery, Paul T.
Paulo, Eugene P.
TI A Systems Design Exploration Approach that Illuminates Tradespaces Using
Statistical Experimental Designs
SO SYSTEMS ENGINEERING
LA English
DT Article
DE simulation metamodeling; tradespace exploration; design of experiments
AB This paper describes an approach that leverages computer simulation models and statistical experimental designs for exploration studies during the early conceptual design of a system. We apply the approach to a naval ship design problem and demonstrate how we can illuminate trade decisions among multiple design decisions and evaluation measures using a dynamic dashboard. After performing experimental designs on a collection of simulation models, we can fit statistical models that act as surrogates to these simulations. These surrogate models allow us to explore a wider variety of system alternatives rather than fixating on a narrow set of alternatives. The purpose of the approach is to simultaneously explore the operational and physical domains using statistical surrogate models in order to illuminate trade decisions between the system's operational effectiveness and physical design considerations. (C) 2016 This article is a U.S. Government work and is in the public domain in the USA.
C1 [MacCalman, Alex D.] US Mil Acad, Dept Syst Engn, West Point, NY 10996 USA.
[Beery, Paul T.; Paulo, Eugene P.] Naval Postgrad Sch, Dept Syst Engn, Monterey, CA 93943 USA.
RP Paulo, EP (reprint author), Naval Postgrad Sch, Dept Syst Engn, Monterey, CA 93943 USA.
EM eppaulo@nps.edu
FU ONR
FX The authors acknowledge a group of researchers who worked on this
ONR-sponsored project, and continue with this effort now under a broader
NATO umbrella. They include Kelly Cooper and Dick Vogelsong from ONR,
Dr. Santiago Balestrini-Robinson and Dr. Charles Domercant from ASDL at
Georgia Tech, Dr. Al Brown from Virginia Tech, Dr. Janel Nixon from
Integrative Engineering LLC, and our Italian colleagues Natalino Dazzi
and Francesco Perra from Orrizonte Sistemi Navali, and Alessandro
Bonvincini from CETENA. The authors would also like to thank the
reviewers for their insightful recommendations.
NR 35
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Z9 0
U1 1
U2 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1098-1241
EI 1520-6858
J9 SYSTEMS ENG
JI Syst. Eng.
PD SEP
PY 2016
VL 19
IS 5
BP 409
EP 421
DI 10.1002/sys.21352
PG 13
WC Engineering, Industrial; Operations Research & Management Science
SC Engineering; Operations Research & Management Science
GA EE1HK
UT WOS:000389331500002
ER
PT J
AU Briant, LJB
Burchell, AE
Ratcliffe, LEK
Charkoudian, N
Nightingale, AK
Paton, JFR
Joyner, MJ
Hart, EC
AF Briant, L. J. B.
Burchell, A. E.
Ratcliffe, L. E. K.
Charkoudian, N.
Nightingale, A. K.
Paton, J. F. R.
Joyner, Michael J.
Hart, E. C.
TI Quantifying sympathetic neuro-haemodynamic transduction at rest in
humans: insights into sex, ageing and blood pressure control
SO JOURNAL OF PHYSIOLOGY-LONDON
LA English
DT Article
ID ALPHA-ADRENERGIC VASOCONSTRICTION; NERVOUS-SYSTEM; NEUROPEPTIDE-Y;
VASCULAR TRANSDUCTION; BAROREFLEX RESPONSES; AUTONOMIC SUPPORT;
ARTERIAL-PRESSURE; MENTAL STRESS; HEALTHY-MEN; AGE
AB Sex and age differences in the sympathetic control of resting blood pressure (BP) may be due to differences in the transduction of sympathetic nerve activity (SNA) into vascular tone. Current methods for dynamically quantifying transduction focus on the relationship between SNA and vasoconstriction during a pressor stimulus, which increases BP and may be contra-indicated in patients. We describe a simple analytical method for quantifying transduction under resting conditions. We performed linear regression analysis of binned muscle SNA burst areas against diastolic BP (DBP). We assessed whether the slope of this relationship reflects the transduction of SNA into DBP. To evaluate this, we investigated whether this measure captures differences in transduction in different populations. Specifically, we (1) quantified transduction in young men (YM), young women (YW), older men (OM) and postmenopausal women (PMW); and (2) measured changes in transduction during beta-blockade using propranolol in YW, YM and PMW. YM had a greater transduction vs. OM(0.10 +/- 0.01 mmHg(%s)(-1), n = 23 vs. 0.06 +/- 0.01 mmHg (% s)(-1), n = 18; P = 0.003). Transduction was lowest in YW(0.02 +/- 0.01 mmHg (% s)(-1), n = 23) and increased during beta-blockade (0.11 +/- 0.01 mmHg(% s)(-1); P<0.001). Transduction in PMW (0.07 +/- 0.01mmHg(% s)(-1), n = 23) was greater compared to YW(P = 0.001), and was not altered during beta-blockade (0.06 +/- 0.01 mmHg (%s)(-1); P = 0.98). Importantly, transduction increased in women with age, but decreased in men. Transduction in women intersected that in men at 55 +/- 1.5 years. This measure of transduction captures age- and sex-differences in the sympathetic regulation of DBP and may be valuable in quantifying transduction in disease. In particular, this measure may help target treatment strategies in specific hypertensive subpopulations.
C1 [Briant, L. J. B.; Burchell, A. E.; Ratcliffe, L. E. K.; Hart, E. C.] Univ Bristol, CardioN, CRIC Bristol, Bristol, Avon, England.
[Charkoudian, N.] US Army, Environm Med Res Inst, Natick, MA 01760 USA.
[Nightingale, A. K.] Univ Hosp Bristol NHS Fdn Trust, Bristol Heart Inst, Bristol, Avon, England.
[Paton, J. F. R.; Hart, E. C.] Univ Bristol, Biomed Sci, Sch Physiol & Pharmacol, Bristol, Avon, England.
[Joyner, Michael J.] Mayo Clin, Rochester, MN USA.
RP Hart, EC (reprint author), Med Sci Bldg, Bristol BS8 1TD, Avon, England.
EM pyecjh@bristol.ac.uk
FU British Heart Foundation, IBSRF [FS/11/1/28400]; AHA [070036Z]; NIH
[HL083947]; National Institute for Health Research Biomedical Research
Unit in Cardiovascular Disease at the University Hospitals Bristol NHS
Foundation Trust and the University of Bristol
FX This study was supported by the British Heart Foundation, IBSRF
FS/11/1/28400 (E.C.H.). Additionally, investigations completed at the
Mayo Clinic were supported by AHA 070036Z (E.C.H.) and NIH HL083947
(M.J.J., N.C.). This research was also supported by the National
Institute for Health Research Biomedical Research Unit in Cardiovascular
Disease at the University Hospitals Bristol NHS Foundation Trust and the
University of Bristol (A.K.N.).
NR 48
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U1 3
U2 3
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-3751
EI 1469-7793
J9 J PHYSIOL-LONDON
JI J. Physiol.-London
PD SEP 1
PY 2016
VL 594
IS 17
BP 4753
EP 4768
DI 10.1113/JP272167
PG 16
WC Neurosciences; Physiology
SC Neurosciences & Neurology; Physiology
GA DW3VL
UT WOS:000383571100014
PM 27068560
ER
PT J
AU Dainer, HM
Kao, S
Feigin, DS
AF Dainer, Hugh M.
Kao, Steve
Feigin, David S.
TI Asthmatic Woman With Shortness of Breath
SO MILITARY MEDICINE
LA English
DT Article
C1 [Dainer, Hugh M.; Kao, Steve] Walter Reed Natl Mil Med Ctr, 8901 Rockville Pike, Bethesda, MD 20889 USA.
[Kao, Steve] Tripler Army Med Ctr, 308 Jarrett White Rd, Honolulu, HI 96819 USA.
[Feigin, David S.] Uniformed Serv Univ Hlth Sci, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.
[Feigin, David S.] Johns Hopkins Univ, 401 North Caroline St, Baltimore, MD 21231 USA.
RP Dainer, HM (reprint author), Walter Reed Natl Mil Med Ctr, 8901 Rockville Pike, Bethesda, MD 20889 USA.
NR 3
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U1 0
U2 0
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD SEP
PY 2016
VL 181
IS 9
BP 949
EP 950
DI 10.7205/MILMED-D-16-00071
PG 2
WC Medicine, General & Internal
SC General & Internal Medicine
GA DW5MV
UT WOS:000383690500008
PM 27612335
ER
EF