FN Thomson Reuters Web of Science™
VR 1.0
PT J
AU Kaplan, L
Sensoy, M
Chakraborty, S
de Mel, G
AF Kaplan, Lance
Sensoy, Murat
Chakraborty, Supriyo
de Mel, Geeth
TI Partial observable update for subjective logic and its application for
trust estimation
SO INFORMATION FUSION
LA English
DT Article
DE Subjective logic; Partial observations; Dirichlet distributions;
Uncertain information; Trust management
ID REPUTATION; MODELS
AB Subjective Logic (SL) is a type of probabilistic logic, which is suitable for reasoning about situations with uncertainty and incomplete knowledge. In recent years, SL has drawn a significant amount of attention from the multi-agent systems community as it connects beliefs and uncertainty in propositions to a rigorous statistical characterization via Dirichlet distributions. However, one serious limitation of SL is that the belief updates are done only based on completely observable evidence. This work extends SL to incorporate belief updates from partially observable evidence. Normally, the belief updates in SL presume that the current evidence for a proposition points to only one of its mutually exclusive attribute states. Instead, this work considers that the current attribute state may not be completely observable, and instead, one is only able to obtain a measurement that is statistically related to this state. In other words, the SL belief is updated based upon the likelihood that one of the attributes was observed. The paper then illustrates properties of the partial observable updates as a function of the state likelihood and illustrates the use of these likelihoods for a trust estimation application. Finally, the utility of the partial observable updates is demonstrated via various simulations including the trust estimation case. (C) 2015 Elsevier B.V. All rights reserved.
C1 [Kaplan, Lance] US Army Res Lab, Adelphi, MD 20783 USA.
[Sensoy, Murat] Ozyegin Univ, Dept Comp Sci, Istanbul, Turkey.
[Chakraborty, Supriyo] Univ Calif Los Angeles, Dept Elect Engn, Los Angeles, CA 90095 USA.
[de Mel, Geeth] IBM TJ Watson Res Ctr, Hawthorne, NY USA.
[Sensoy, Murat] Univ Aberdeen, Dept Comp Sci, Aberdeen AB9 1FX, Scotland.
RP Sensoy, M (reprint author), Ozyegin Univ, Dept Comp Sci, Istanbul, Turkey.
EM lkaplan@ieee.org; murat.sensoy@ozyegin.edu.tr; supriyo@ucla.edu;
grdemel@us.ibm.com
FU U.S. Army Research Laboratory; U.K. Ministry of Defence
[W911NF-06-3-0001, W911NF-13-1-0243]; U.S. Army Research Laboratory
[W911NF-14-1-0199]; Scientific and Technological Research Council of
Turkey (TUBITAK) [113E238]
FX Research was sponsored by the U.S. Army Research Laboratory and the U.K.
Ministry of Defence and was accomplished under Agreement Numbers
W911NF-06-3-0001 and W911NF-13-1-0243. The views and conclusions
contained in this document are those of the author(s) and should not be
interpreted as representing the official policies, either expressed or
implied, of the U.S. Army Research Laboratory, the U.S. Government, the
U.K. Ministry of Defence or the U.K. Government. The U.S. and U.K.
Governments are authorized to reproduce and distribute reprints for
Government purposes notwithstanding any copyright notation hereon.; Dr.
sensoy thanks to the U.S. Army Research Laboratory for its support under
Grant W911NF-14-1-0199 and The Scientific and Technological Research
Council of Turkey (TUBITAK) for its support under Grant 113E238.
NR 51
TC 1
Z9 1
U1 1
U2 12
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1566-2535
EI 1872-6305
J9 INFORM FUSION
JI Inf. Fusion
PD NOV
PY 2015
VL 26
BP 66
EP 83
DI 10.1016/j.inffus.2015.01.005
PG 18
WC Computer Science, Artificial Intelligence; Computer Science, Theory &
Methods
SC Computer Science
GA CK3NB
UT WOS:000356121700004
ER
PT J
AU Li, YF
Chen, N
Harmon, ME
Li, Y
Cao, XY
Chappell, MA
Mao, JD
AF Li, Yongfu
Chen, Na
Harmon, Mark E.
Li, Yuan
Cao, Xiaoyan
Chappell, Mark A.
Mao, Jingdong
TI Plant Species Rather Than Climate Greatly Alters the Temporal Pattern of
Litter Chemical Composition During Long-Term Decomposition
SO SCIENTIFIC REPORTS
LA English
DT Article
ID C-13 NMR-SPECTROSCOPY; SOIL ORGANIC-MATTER; SOLID-STATE NMR;
LEAF-LITTER; FINE ROOTS; MASS-LOSS; QUALITY; DYNAMICS; CHEMISTRY; FOREST
AB A feedback between decomposition and litter chemical composition occurs with decomposition altering composition that in turn influences the decomposition rate. Elucidating the temporal pattern of chemical composition is vital to understand this feedback, but the effects of plant species and climate on chemical changes remain poorly understood, especially over multiple years. In a 10-year decomposition experiment with litter of four species (Acer saccharum, Drypetes glauca, Pinus resinosa, and Thuja plicata) from four sites that range from the arctic to tropics, we determined the abundance of 11 litter chemical constituents that were grouped into waxes, carbohydrates, lignin/tannins, and proteins/peptides using advanced 13C solid-state NMR techniques. Decomposition generally led to an enrichment of waxes and a depletion of carbohydrates, whereas the changes of other chemical constituents were inconsistent. Inconsistent convergence in chemical compositions during decomposition was observed among different litter species across a range of site conditions, whereas one litter species converged under different climate conditions. Our data clearly demonstrate that plant species rather than climate greatly alters the temporal pattern of litter chemical composition, suggesting the decomposition-chemistry feedback varies among different plant species.
C1 [Li, Yongfu] Zhejiang A&F Univ, Zhejiang Prov Key Lab Carbon Cycling Forest Ecosy, Linan 311300, Peoples R China.
[Li, Yongfu; Chen, Na; Li, Yuan; Cao, Xiaoyan; Mao, Jingdong] Old Dominion Univ, Dept Chem & Biochem, Norfolk, VA 23529 USA.
[Harmon, Mark E.] Oregon State Univ, Dept Forest Ecosyst & Soc, Corvallis, OR 97331 USA.
[Chappell, Mark A.] US Army, Corps Engineers, Environm Lab, Vicksburg, MS 39180 USA.
RP Li, YF (reprint author), Zhejiang A&F Univ, Zhejiang Prov Key Lab Carbon Cycling Forest Ecosy, Linan 311300, Peoples R China.
EM yongfuli@zafu.edu.cn; jmao@odu.edu
RI Cao, Xiaoyan/E-3492-2012
OI Cao, Xiaoyan/0000-0001-7571-6482
FU National Science Foundation [DEB-9108329, DEB-9806493]; Kaye and Ward
Richardson Endowment
FX This study would not have been possible without the dedicated efforts of
many people, who have participated in the LIDET study. In addition to
the numerous grants that supported personnel at the individual sites,
this study was supported by grants from the National Science Foundation
(DEB-9108329, DEB-9806493) and the Kaye and Ward Richardson Endowment.
NR 42
TC 3
Z9 3
U1 5
U2 39
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD OCT 30
PY 2015
VL 5
AR 15783
DI 10.1038/srep15783
PG 13
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CU8NQ
UT WOS:000363800200001
PM 26515033
ER
PT J
AU Knap, J
Spear, CE
Borodin, O
Leiter, KW
AF Knap, J.
Spear, C. E.
Borodin, O.
Leiter, K. W.
TI Advancing a distributed multi-scale computing framework for large-scale
high-throughput discovery in materials science
SO NANOTECHNOLOGY
LA English
DT Article
DE multi-scale modeling; high-throughput discovery; parallel computing
ID INFRASTRUCTURE; IDENTIFICATION; DESIGN
AB We describe the development of a large-scale high-throughput application for discovery in materials science. Our point of departure is a computational framework for distributed multi-scale computation. We augment the original framework with a specialized module whose role is to route evaluation requests needed by the high-throughput application to a collection of available computational resources. We evaluate the feasibility and performance of the resulting high-throughput computational framework by carrying out a high-throughput study of battery solvents. Our results indicate that distributed multi-scale computing, by virtue of its adaptive nature, is particularly well-suited for building high-throughput applications.
C1 [Knap, J.; Spear, C. E.; Leiter, K. W.] US Army, Simulat Sci Branch, RDRL CIH C, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
[Borodin, O.] US Army, Electrochem Branch, RDRL SED C, Res Lab, Adelphi, MD 20783 USA.
RP Knap, J (reprint author), US Army, Simulat Sci Branch, RDRL CIH C, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
EM jaroslaw.knap@us.army.mil
RI Borodin, Oleg/B-6855-2012
OI Borodin, Oleg/0000-0002-9428-5291
NR 32
TC 4
Z9 4
U1 3
U2 17
PU IOP PUBLISHING LTD
PI BRISTOL
PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
SN 0957-4484
EI 1361-6528
J9 NANOTECHNOLOGY
JI Nanotechnology
PD OCT 30
PY 2015
VL 26
IS 43
AR 434004
DI 10.1088/0957-4484/26/43/434004
PG 11
WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary;
Physics, Applied
SC Science & Technology - Other Topics; Materials Science; Physics
GA CU3OE
UT WOS:000363433900005
PM 26443333
ER
PT J
AU Migliaccio, CP
Lazarus, N
AF Migliaccio, Christopher P.
Lazarus, Nathan
TI Fabrication of hierarchically structured superhydrophobic PDMS surfaces
by Cu and CuO casting
SO APPLIED SURFACE SCIENCE
LA English
DT Article
DE PDMS; Superhydrophobic; Microfluidics; Hierarchical roughness;
Self-cleaning
ID MICROFLUIDIC DEVICES; WETTABILITY; ROUGHNESS; STATES; WATER
AB Poly(dimethylsiloxane) (PDMS) films decorated with hierarchically structured pillars are cast from large area copper and copper oxide negative molds. The molds are fabricated using a single patterning step and electroplating. The process of casting structured PDMS films is simpler and cheaper than alternatives based on deep reactive ion etching or laser roughening of bulk silicone. Texture imparted to the pillars from the mold walls renders the PDMS films superhydrophobic, with the contact angle/hysteresis of the most non-wetting surfaces measuring 164 degrees/19 degrees and 158 degrees/110 degrees for surfaces with and without application of a low surface energy coating. The usefulness of patterned PDMS films as a "self-cleaning" solar cell module covering is demonstrated and other applications are discussed. Published by Elsevier B.V.
C1 [Migliaccio, Christopher P.; Lazarus, Nathan] US Army Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA.
RP Migliaccio, CP (reprint author), US Army Res Lab, Sensors & Elect Devices Directorate, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM christopher.p.migliaccio.civ@mail.mil
FU Army Research Laboratory [W911NF-12-2-0019]
FX The authors thank Kimberly Sablon and John Little for use of their solar
simulator. This work was sponsored by the Army Research Laboratory and
was accomplished in part under Cooperative Agreement Number
W911NF-12-2-0019. The views and conclusions contained in this document
are those of the authors and should not be interpreted as representing
the official policies, either expressed or implied, of the Army Research
Laboratory of the U.S. Government. The SEMASC facilities at the U.S.
Army Research Laboratory were used to fabricate devices in this work.
NR 28
TC 3
Z9 3
U1 7
U2 75
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0169-4332
EI 1873-5584
J9 APPL SURF SCI
JI Appl. Surf. Sci.
PD OCT 30
PY 2015
VL 353
BP 269
EP 274
DI 10.1016/j.apsusc.2015.06.095
PG 6
WC Chemistry, Physical; Materials Science, Coatings & Films; Physics,
Applied; Physics, Condensed Matter
SC Chemistry; Materials Science; Physics
GA CR3GW
UT WOS:000361220700035
ER
PT J
AU Jin, ZH
Nori, S
Lee, YF
Kumar, D
Wu, F
Prater, JT
Kim, KW
Narayan, J
AF Jin, Zhenghe
Nori, Sudhakar
Lee, Yi-Fang
Kumar, D.
Wu, Fan
Prater, J. T.
Kim, Ki Wook
Narayan, Jagdish
TI Strain induced room temperature ferromagnetism in epitaxial magnesium
oxide thin films
SO JOURNAL OF APPLIED PHYSICS
LA English
DT Article
ID TOPOLOGICAL INSULATOR
AB We report on the epitaxial growth and room-temperature ferromagnetic properties of MgO thin films deposited on hexagonal c-sapphire substrates by pulsed laser deposition. The epitaxial nature of the films has been confirmed by both theta-2 theta and phi-scans of X-ray diffraction pattern. Even though bulk MgO is a nonmagnetic insulator, we have found that the MgO films exhibit ferromagnetism and hysteresis loops yielding a maximum saturation magnetization up to 17 emu/cc and large coercivity, H-c = 1200 Oe. We have also found that the saturation magnetization gets enhanced and that the crystallization degraded with decreased growth temperature, suggesting that the origin of our magnetic coupling could be point defects manifested by the strain in the films. X-ray (theta-2 theta) diffraction peak shift and strain analysis clearly support the presence of strain in films resulting from the presence of point defects. Based on careful investigations using secondary ion mass spectrometer and X-ray photoelectron spectroscopy studies, we have ruled out the possibility of the presence of any external magnetic impurities. We discuss the critical role of microstructural characteristics and associated strain on the physical properties of the MgO films and establish a correlation between defects and magnetic properties. (C) 2015 AIP Publishing LLC.
C1 [Jin, Zhenghe; Kim, Ki Wook] N Carolina State Univ, Dept Elect & Comp Engn, Raleigh, NC 27695 USA.
[Nori, Sudhakar; Lee, Yi-Fang; Narayan, Jagdish] N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA.
[Kumar, D.] N Carolina Agr & Tech State Univ, Dept Mech Engn, Greensboro, NC 27411 USA.
[Wu, Fan] Princeton Univ, Princeton Inst Sci & Technol Mat PRISM, Princeton, NJ 08540 USA.
[Prater, J. T.] Army Res Off, Div Mat Sci, Res Triangle Pk, NC 27709 USA.
RP Jin, ZH (reprint author), N Carolina State Univ, Dept Elect & Comp Engn, Raleigh, NC 27695 USA.
RI Nori, Sudhakar/E-8111-2010;
OI , fan/0000-0001-5000-0592
FU National Science Foundation [ECCS-1306400]; FAME (one of six centers of
STARnet, a SRC program - MARCO); FAME (DARPA)
FX This work was supported, in part, by National Science Foundation
ECCS-1306400 and FAME (one of six centers of STARnet, a SRC program
sponsored by MARCO and DARPA).
NR 21
TC 0
Z9 0
U1 0
U2 11
PU AMER INST PHYSICS
PI MELVILLE
PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA
SN 0021-8979
EI 1089-7550
J9 J APPL PHYS
JI J. Appl. Phys.
PD OCT 28
PY 2015
VL 118
IS 16
AR 165309
DI 10.1063/1.4934498
PG 6
WC Physics, Applied
SC Physics
GA CV6VR
UT WOS:000364410300047
ER
PT J
AU Schultz, MT
Lance, RF
AF Schultz, Martin T.
Lance, Richard F.
TI Modeling the Sensitivity of Field Surveys for Detection of Environmental
DNA (eDNA)
SO PLOS ONE
LA English
DT Article
ID WATER SAMPLES; PRESENCE/ABSENCE; BIODIVERSITY; OCCUPANCY; PARTICLE;
CAPTURE; ECOLOGY; RARE; CARP; TOOL
AB The environmental DNA (eDNA) method is the practice of collecting environmental samples and analyzing them for the presence of a genetic marker specific to a target species. Little is known about the sensitivity of the eDNA method. Sensitivity is the probability that the target marker will be detected if it is present in the water body. Methods and tools are needed to assess the sensitivity of sampling protocols, design eDNA surveys, and interpret survey results. In this study, the sensitivity of the eDNA method is modeled as a function of ambient target marker concentration. The model accounts for five steps of sample collection and analysis, including: 1) collection of a filtered water sample from the source; 2) extraction of DNA from the filter and isolation in a purified elution; 3) removal of aliquots from the elution for use in the polymerase chain reaction (PCR) assay; 4) PCR; and 5) genetic sequencing. The model is applicable to any target species. For demonstration purposes, the model is parameterized for bighead carp (Hypophthalmichthys nobilis) and silver carp (H. molitrix) assuming sampling protocols used in the Chicago Area Waterway System (CAWS). Simulation results show that eDNA surveys have a high false negative rate at low concentrations of the genetic marker. This is attributed to processing of water samples and division of the extraction elution in preparation for the PCR assay. Increases in field survey sensitivity can be achieved by increasing sample volume, sample number, and PCR replicates. Increasing sample volume yields the greatest increase in sensitivity. It is recommended that investigators estimate and communicate the sensitivity of eDNA surveys to help facilitate interpretation of eDNA survey results. In the absence of such information, it is difficult to evaluate the results of surveys in which no water samples test positive for the target marker. It is also recommended that invasive species managers articulate concentration-based sensitivity objectives for eDNA surveys. In the absence of such information, it is difficult to design appropriate sampling protocols. The model provides insights into how sampling protocols can be designed or modified to achieve these sensitivity objectives.
C1 [Schultz, Martin T.; Lance, Richard F.] US Army Corps Engn, Engn Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA.
RP Schultz, MT (reprint author), US Army Corps Engn, Engn Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA.
EM Martin.T.Schultz@usace.army.mil
FU U.S. Environmental Protection Agency Great Lakes Restoration Initiative
through the Asian Carp Regional Coordinating Committee; U.S. Army Corps
of Engineers
FX This study was part of the Environmental DNA Calibration Study funded by
the U.S. Environmental Protection Agency Great Lakes Restoration
Initiative (http://greatlakesrestoration.us) through the Asian Carp
Regional Coordinating Committee (http://www.asiancarp.us) and the U.S.
Army Corps of Engineers. The funders had no role in study design, data
collection and analysis, decision to publish, or preparation of the
manuscript.
NR 34
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Z9 3
U1 8
U2 58
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD OCT 28
PY 2015
VL 10
IS 10
AR e0141503
DI 10.1371/journal.pone.0141503
PG 16
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CV0DL
UT WOS:000363918100094
PM 26509674
ER
PT J
AU Walker, PF
Buehner, MF
Wood, LA
Boyer, NL
Driscoll, IR
Lundy, JB
Cancio, LC
Chung, KK
AF Walker, Patrick F.
Buehner, Michelle F.
Wood, Leslie A.
Boyer, Nathan L.
Driscoll, Ian R.
Lundy, Jonathan B.
Cancio, Leopoldo C.
Chung, Kevin K.
TI Diagnosis and management of inhalation injury: an updated review
SO CRITICAL CARE
LA English
DT Review
ID FREQUENCY PERCUSSIVE VENTILATION; ACUTE LUNG INJURY; ACUTE
SMOKE-INHALATION; PEROXYNITRITE DECOMPOSITION CATALYST;
RESPIRATORY-DISTRESS-SYNDROME; COMPUTED TOMOGRAPHIC SCANS; BURN
PATIENTS; MECHANICAL VENTILATION; FIBEROPTIC BRONCHOSCOPY; ENDOTRACHEAL
INTUBATION
AB In this article we review recent advances made in the pathophysiology, diagnosis, and treatment of inhalation injury. Historically, the diagnosis of inhalation injury has relied on nonspecific clinical exam findings and bronchoscopic evidence. The development of a grading system and the use of modalities such as chest computed tomography may allow for a more nuanced evaluation of inhalation injury and enhanced ability to prognosticate. Supportive respiratory care remains essential in managing inhalation injury. Adjuncts still lacking definitive evidence of efficacy include bronchodilators, mucolytic agents, inhaled anticoagulants, nonconventional ventilator modes, prone positioning, and extracorporeal membrane oxygenation. Recent research focusing on molecular mechanisms involved in inhalation injury has increased the number of potential therapies.
C1 [Walker, Patrick F.] Walter Reed Natl Mil Med Ctr, Dept Surg, Bethesda, MD 20889 USA.
[Buehner, Michelle F.] San Antonio Mil Med Ctr, Dept Gen Surg, Ft Sam Houston, TX 78234 USA.
[Wood, Leslie A.; Boyer, Nathan L.] San Antonio Mil Med Ctr, Dept Med, Ft Sam Houston, TX 78234 USA.
[Driscoll, Ian R.; Lundy, Jonathan B.; Cancio, Leopoldo C.; Chung, Kevin K.] US Army Inst Surg Res, Ft Sam Houston, TX 78234 USA.
[Chung, Kevin K.] Uniformed Serv Univ Hlth Sci, Dept Surg, Bethesda, MD 20814 USA.
RP Buehner, MF (reprint author), San Antonio Mil Med Ctr, Dept Gen Surg, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
EM michelle.f.buehner.mil@mail.mil
FU Percussionaire, Inc.; Maquet Medical Systems; Novalung GmbH; Alung
Technologies, Inc.; Oridion Capnography, Inc.
FX LCC received funding from Percussionaire, Inc. to speak at the Bird
Institute, Sandpoint, ID (2013). The author's institution (USAISR) has
received research support in the form of equipment loans from Maquet
Medical Systems, Novalung GmbH, Alung Technologies, Inc. and Oridion
Capnography, Inc.
NR 105
TC 8
Z9 10
U1 1
U2 7
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1466-609X
EI 1364-8535
J9 CRIT CARE
JI Crit. Care
PD OCT 28
PY 2015
VL 19
AR 351
DI 10.1186/s13054-015-1077-4
PG 12
WC Critical Care Medicine
SC General & Internal Medicine
GA CU6CS
UT WOS:000363619700001
PM 26507130
ER
PT J
AU Jahnke, JP
Bazan, GC
Sumner, JJ
AF Jahnke, Justin P.
Bazan, Guillermo C.
Sumner, James J.
TI Effect of Modified Phospholipid Bilayers on the Electrochemical Activity
of a Membrane-Spanning Conjugated Oligoelectrolyte
SO LANGMUIR
LA English
DT Article
ID SUPPORTED LIPID-BILAYERS; SHEWANELLA-ONEIDENSIS; ELECTRON-TRANSFER;
BILE-ACIDS; CHOLESTEROL; PERTURBATION; MOLECULES
AB The incorporation and electrochemical activity of a conjugated oligoelectrolyte (COE) in model phospholipid bilayers have been characterized using cyclic voltammetry and UV-vis absorption measurements. Several other modifiers were also incorporated into the phospholipid membranes to alter properties such as charge and alkyl chain disorder. Using potassium ferricyanide to measure charge transport, it was observed that bilayers that contained cholic acid, a negatively charged additive that also promotes alkyl chain disorder, had higher COE uptake and charge permeability than unmodified bilayers. In contrast, when the positively charged choline was incorporated, charge permeability decreased and COE uptake was similar to that of unmodified bilayers. The incorporation of cholesterol at low concentrations within the phospholipid membranes was shown to enhance the COE's effectiveness at increasing membrane charge permeability without increasing the COE concentration in the bilayer. Higher concentrations of cholesterol reduce membrane fluidity and membrane charge permeability. Collectively, these results demonstrate that changes in phospholipid membrane charge permeability upon COE incorporation depend not only on the concentration in the membrane but also on interactions with the phospholipid bilayer and other additives present in the membranes. This approach of manipulating the properties of phospholipid membranes to understand COE interactions is applicable to understanding the behavior of a wide range of molecules that impart useful properties to phospholipid membranes.
C1 [Jahnke, Justin P.; Sumner, James J.] US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA.
[Bazan, Guillermo C.] Univ Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA.
RP Sumner, JJ (reprint author), US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA.
RI Bazan, Guillermo/B-7625-2014
NR 29
TC 3
Z9 3
U1 3
U2 9
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0743-7463
J9 LANGMUIR
JI Langmuir
PD OCT 27
PY 2015
VL 31
IS 42
BP 11613
EP 11620
DI 10.1021/acs.langmuir.5b03093
PG 8
WC Chemistry, Multidisciplinary; Chemistry, Physical; Materials Science,
Multidisciplinary
SC Chemistry; Materials Science
GA CV0CI
UT WOS:000363914600029
PM 26422050
ER
PT J
AU Faria, M
Garcia-Reyero, N
Padros, F
Babin, PJ
Sebastian, D
Cachot, J
Prats, E
Arick, M
Rial, E
Knoll-Gellida, A
Mathieu, G
Le Bihanic, F
Escalon, BL
Zorzano, A
Soares, AMVM
Raldua, D
AF Faria, Melissa
Garcia-Reyero, Natalia
Padros, Francesc
Babin, Patrick J.
Sebastian, David
Cachot, Jerome
Prats, Eva
Arick, Mark, II
Rial, Eduardo
Knoll-Gellida, Anja
Mathieu, Guilaine
Le Bihanic, Florane
Escalon, B. Lynn
Zorzano, Antonio
Soares, Amadeu M. V. M.
Raldua, Demetrio
TI Zebrafish Models for Human Acute Organophosphorus Poisoning
SO SCIENTIFIC REPORTS
LA English
DT Article
ID SOMAN; CHLORPYRIFOS; SYSTEM; RATS
AB Terrorist use of organophosphorus-based nerve agents and toxic industrial chemicals against civilian populations constitutes a real threat, as demonstrated by the terrorist attacks in Japan in the 1990 s or, even more recently, in the Syrian civil war. Thus, development of more effective countermeasures against acute organophosphorus poisoning is urgently needed. Here, we have generated and validated zebrafish models for mild, moderate and severe acute organophosphorus poisoning by exposing zebrafish larvae to different concentrations of the prototypic organophosphorus compound chlorpyrifos-oxon. Our results show that zebrafish models mimic most of the pathophysiological mechanisms behind this toxidrome in humans, including acetylcholinesterase inhibition, N-methyl-D-aspartate receptor activation, and calcium dysregulation as well as inflammatory and immune responses. The suitability of the zebrafish larvae to in vivo high-throughput screenings of small molecule libraries makes these models a valuable tool for identifying new drugs for multifunctional drug therapy against acute organophosphorus poisoning.
C1 [Faria, Melissa; Soares, Amadeu M. V. M.] Univ Aveiro, Dept Biol, Aveiro, Portugal.
[Faria, Melissa; Soares, Amadeu M. V. M.] Univ Aveiro, CESAM, Aveiro, Portugal.
[Faria, Melissa; Raldua, Demetrio] CSIC, IDAEA, ES-08034 Barcelona, Spain.
[Garcia-Reyero, Natalia; Arick, Mark, II] US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS USA.
[Garcia-Reyero, Natalia] Mississippi State Univ, Inst Gen Biocomp & Biotechnol IGBB, Starkville, MS USA.
[Padros, Francesc] Univ Autonoma Barcelona, Pathol Diagnost Serv Fish, Bellaterra 08190, Spain.
[Babin, Patrick J.; Knoll-Gellida, Anja; Mathieu, Guilaine] Univ Bordeaux, Rare Dis Genet & Metab MRGM, EA 4576, F-3340 Talence, France.
[Sebastian, David; Zorzano, Antonio] Inst Res Biomed IRB Barcelona, Barcelona 08028, Spain.
[Sebastian, David; Zorzano, Antonio] Univ Barcelona, Fac Biol, Dept Bioquim & Biol Mol, E-08028 Barcelona, Spain.
[Sebastian, David; Zorzano, Antonio] CIBERDEM, Inst Salud Carlos III, Barcelona 08017, Spain.
[Cachot, Jerome; Le Bihanic, Florane; Escalon, B. Lynn] Univ Bordeaux, CNRS, EPOC, UMR 5805, F-33405 Talence, France.
[Prats, Eva] CSIC, Cid, ES-08034 Barcelona, Spain.
[Rial, Eduardo] CSIC, CIB, Dept Cellular & Mol Med, E-28040 Madrid, Spain.
RP Raldua, D (reprint author), CSIC, IDAEA, Jordi Girona 18, ES-08034 Barcelona, Spain.
EM drpqam@cid.csic.es
RI Soares, Amadeu/A-8304-2008; Rial, Eduardo/A-4242-2008; CESAM,
UA/M-3762-2015;
OI Soares, Amadeu/0000-0003-0879-9470; Rial, Eduardo/0000-0001-8634-8902;
Raldua, Demetrio/0000-0001-5256-1641
FU US Army ERDC-IRO [W912HZ-13-BAA-01]; Environmental Quality Research
Program; NATO SfP project [MD.SFPP 984777]; National Science Foundation
EPSCOR Grant [EPS-0903787]; Portuguese Foundation for Science and
Technology [SFRH/BPD/78342/2011]; Advanced Grant [ERC-2012-AdG-320737];
Spanish Government [CTM2014-51985-R]
FX We thank Dr. Mike Murphy for providing mitoQ and Dr. Harold A. Burgess
for providing Flote software and advice with the kinematic analysis. We
are also grateful to Dr. A. Sanchez-Chardi and the staff at the Servei
de Microscopia of the Universitat Autonoma de Barcelona for their
support in TEM processing and observation, and to Claudia Rivetti for
her relevant support in the chemical analysis. The F59 antibody,
developed by Frank E. Stockdale, was obtained from the Developmental
Studies Hybridoma Bank, created by the NICHD of the NIH and maintained
at The University of Iowa, Department of Biology, Iowa City, IA 52242.
This work was supported in part by the US Army ERDC-IRO
(W912HZ-13-BAA-01; D.R., N.G.R., and P.J.B.) and Environmental Quality
Research Program (N.G.R.), the NATO SfP project MD.SFPP 984777 (D.R.,
N.G.R., and P.J.B.), the National Science Foundation EPSCOR Grant
EPS-0903787 (N.G.R.), the Portuguese Foundation for Science and
Technology Grant SFRH/BPD/78342/2011 (Programme POPH - QREN through the
Portuguese Ministry of Education and Science and the European Social
Fund; M.F.), the Advanced Grant ERC-2012-AdG-320737 (D.R.) and the
Spanish Government (CTM2014-51985-R; D.R.).
NR 36
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U2 19
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD OCT 22
PY 2015
VL 5
AR 15591
DI 10.1038/srep15591
PG 15
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CT9MF
UT WOS:000363140500001
PM 26489395
ER
PT J
AU Salas, MM
McIntyre, MK
Petz, LN
Korz, W
Wong, D
Clifford, JL
AF Salas, Margaux M.
McIntyre, Matthew K.
Petz, Lawrence N.
Korz, Walter
Wong, Donald
Clifford, John L.
TI Tetrodotoxin suppresses thermal hyperalgesia and mechanical allodynia in
a rat full thickness thermal injury pain model
SO NEUROSCIENCE LETTERS
LA English
DT Article
DE Tetrodotoxin; Thermal injury; Thermal hyperalgesia; Mechanical allodynia
ID BENZODIAZEPINE WITHDRAWAL SYNDROME; OPIOID-INDUCED HYPERALGESIA; ADULT
BURN PATIENTS; SODIUM-CHANNELS; CANCER PAIN; OPEN-LABEL; MULTICENTER;
NOCICEPTION; CASUALTIES; SAXITOXIN
AB Burn injuries have been identified as the primary cause of injury in 5% of U.S. military personnel evacuated from Operations Iraqi Freedom and Enduring Freedom. Severe burn-associated pain is typically treated with opioids such as fentanyl, morphine, and methadone. Side effects of opioids include respiratory depression, cardiac depression, decrease in motor and cognitive function, as well as the development of hyperalgesia, tolerance and dependence. These effects have led us to search for novel analgesics for the treatment of burn-associated pain in wounded combat service members. Tetrodotoxin (TTX) is a selective voltage-gated sodium channel blocker currently in clinical trials as an analgesic. A phase 3 clinical trial for cancer-related pain has been completed and phase 3 clinical trials on chemotherapy-induced neuropathic pain are planned. It has also been shown in mice to inhibit the development of chemotherapy-induced neuropathic pain. TTX was originally identified as a neurotoxin in marine animals but has now been shown to be safe in humans at therapeutic doses. The antinociceptive effects of TTX are thought to be due to inhibition of Na+ ion influx required for initiation and conduction of nociceptive impulses. One TTX sensitive sodium channel, Na-v 1.7, has been shown to be essential in lowering the heat pain threshold after burn injuries. To date, the analgesic effect of TTX has not been tested in burn-associated pain. Male Sprague-Dawley rats were subjected to a full thickness thermal injury on the right hind paw. TTX (8 mu g/kg) was administered once a day systemically by subcutaneous injection beginning 3 days post thermal injury and continued through 7 days post thermal injury. Thermal hyperalgesia and mechanical allodynia were assessed 60 and 120 mm post injection on each day of TTX treatment. TTX significantly reduced thermal hyperalgesia at all days tested and had a less robust, but statistically significant suppressive effect on mechanical allodynia. These results suggest that systemic TTX may be an effective, rapidly acting analgesic for battlefield burn injuries and has the potential for replacing or reducing the need for opioid analgesics. Published by Elsevier Ireland Ltd.
C1 [Salas, Margaux M.; McIntyre, Matthew K.; Petz, Lawrence N.; Clifford, John L.] US Army, Inst Surg Res, Jbsa Ft Sam Houston, TX 78234 USA.
[Korz, Walter; Wong, Donald] WEX Pharmaceut Inc, Vancouver, BC V6E 2N7, Canada.
RP Clifford, JL (reprint author), US Army, Inst Surg Res, 3698 Chambers Pass,Bldg 3611, Jbsa Ft Sam Houston, TX 78234 USA.
EM john.l.clifford11.civ@mail.mil
FU WEX Pharmaceuticals Inc.; United States Army Medical Research Program;
Material Command Combat Casualty Care and Clinical and Rehabilitative
Medicine Research Program
FX We acknowledge Bopaiah Cheppudira, Dayna Loyd-Averitt, and Alberto Mares
for helpful discussions. We also acknowledge Jay Aiden for assistance
with statistical analysis. This work was supported by funding from WEX
Pharmaceuticals Inc. and the United States Army Medical Research and
Material Command Combat Casualty Care and Clinical and Rehabilitative
Medicine Research Programs. This study was conducted in compliance with
the Animal Welfare Act, the implementing Animal Welfare Regulations, and
the principles of the Guide for the Care and Use of Laboratory Animals.
The opinions or assertions contained herein are the private views of the
authors and are not to be construed as official or as reflecting the
views of the Department of the Army or the Department of Defense.
NR 26
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U1 1
U2 8
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 0304-3940
EI 1872-7972
J9 NEUROSCI LETT
JI Neurosci. Lett.
PD OCT 21
PY 2015
VL 607
BP 108
EP 113
DI 10.1016/j.neulet.2015.09.031
PG 6
WC Neurosciences
SC Neurosciences & Neurology
GA CW3KK
UT WOS:000364891000019
PM 26424077
ER
PT J
AU Daczkowski, CM
Pegan, SD
Harvey, SP
AF Daczkowski, Courtney M.
Pegan, Scott D.
Harvey, Steven P.
TI Engineering the Organophosphorus Acid Anhydrolase Enzyme for Increased
Catalytic Efficiency and Broadened Stereospecificity on Russian VX
SO BIOCHEMISTRY
LA English
DT Article
ID NUCLEOTIDE-SEQUENCE; NERVE AGENTS
AB The enzyme organophosphorus acid anhydrolase (OPAA), from Alteromonas sp. JD6.5, has been shown to rapidly catalyze the hydrolysis of a number of toxic organophosphorus compounds, including several G-type chemical nerve agents. The enzyme was cloned into Escherichia coli and can be produced up to approximately 50% of cellular protein. There have been no previous reports of OPAA activity on VR {Russian VX, O-isobutyl S[2-(diethylamino)ethyl] methylphosphonothioate}, and our studies reported here show that wild-type OPAA has poor catalytic efficacy toward YR. However, via application of a structurally aided protein engineering approach, significant improvements in catalytic efficiency were realized via optimization of the small pocket within the OPAA's substrate-binding site. This optimization involved alterations at only three amino acid sites resulting in a 30-fold increase in catalytic efficiency toward racemic VR, with a strong stereospecificity toward the P(+) enantiomer. X-ray structures of this mutant as well as one of its predecessors provide potential structural rationales for their effect on the OPAA active site. Additionally, a fourth mutation at a site near the small pocket was found to relax the stereospecificity of the OPAA enzyme. Thus, it allows the altered enzyme to effectively process both VR enantiomers and should be a useful genetic background in which to seek further improvements in OPAA VR activity.
C1 [Daczkowski, Courtney M.; Pegan, Scott D.] Univ Georgia, Dept Pharmaceut & Biomed Sci, Athens, GA 30602 USA.
[Pegan, Scott D.] US Army, Reserve Sustainment Command 377th, Aberdeen Proving Ground, MD 21010 USA.
[Harvey, Steven P.] US Army, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA.
RP Pegan, SD (reprint author), Univ Georgia, Coll Pharm, 422 Pharm South, Athens, GA 30602 USA.
EM spegan@uga.edu; steven.p.harvey6.civ@mail.mil
FU Defense Threat Reduction Agency [CB3742]; U.S. Department of Energy,
Office of Science, Office of Basic Energy Sciences [W-31-109-Eng-38]
FX This research was supported by funds made available by the Defense
Threat Reduction Agency CB3742 (S.P.H.). Use of the Advanced Photon
Source was supported by the U.S. Department of Energy, Office of
Science, Office of Basic Energy Sciences, under Contract W-31-109-Eng-38
(S.D.P.).
NR 21
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U1 5
U2 13
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0006-2960
J9 BIOCHEMISTRY-US
JI Biochemistry
PD OCT 20
PY 2015
VL 54
IS 41
BP 6423
EP 6433
DI 10.1021/acs.biochem.5b00624
PG 11
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA CU2IQ
UT WOS:000363347600015
PM 26418828
ER
PT J
AU Kennedy, AJ
Hull, MS
Diamond, S
Chappell, M
Bednar, AJ
Laird, JG
Melby, NL
Steeyens, JA
AF Kennedy, Alan J.
Hull, Matthew S.
Diamond, Stephen
Chappell, Mark
Bednar, Anthony J.
Laird, Jennifer G.
Melby, Nicholas L.
Steeyens, Jeffery A.
TI Gaining a Critical Mass: A Dose Metric Conversion Case Study Using
Silver Nanoparticles
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID ION-RELEASE KINETICS; DAPHNIA-MAGNA; SURFACE-AREA; ANTIBACTERIAL
ACTIVITY; AQUATIC ORGANISMS; MANUFACTURED NANOMATERIALS;
ESCHERICHIA-COLI; DISSOLVED SILVER; OXIDATIVE STRESS; CHRONIC TOXICITY
AB Mass concentration is the standard convention to express exposure in ecotoxicology for dissolved substances. However, nanotoxicology has challenged the suitability of the mass concentration dose metric. Alternative metrics often discussed in the literature include particle number, surface area, and ion release (kinetics, equilibrium). It is unlikely that any single metric is universally applicable to all types of nanopartides. However, determining the optimal metric for a specific type of nanopartide requires novel studies to generate supportive data and employ methods to compensate for current analytical capability gaps. This investigation generated acute toxicity data for two standard species (Ceriodaphnia dubia, Pimephales promelas) exposed to five sizes (10, 20, 30, 60, 100 nm) of monodispersed citrate- and polyvinylpyrrolidonecoated silver nanopartides. Particles were sized by various techniques to populate available models for expressing the particle number, surface area, and dissolved fraction. Results indicate that the acute toxicity of the tested silver nanoparticles is best expressed by ion release, and is relatable to total exposed surface area. Particle number was not relatable to the observed acute silver nanoparticle effects.
C1 [Kennedy, Alan J.; Chappell, Mark; Bednar, Anthony J.; Laird, Jennifer G.; Melby, Nicholas L.; Steeyens, Jeffery A.] US Army, Engn Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA.
[Hull, Matthew S.] Virginia Tech Inst Crit Technol & Appl Sci ICTAS, Blacksburg, VA 24060 USA.
[Hull, Matthew S.; Diamond, Stephen] NanoSafe Inc, Blacksburg, VA 24060 USA.
RP Kennedy, AJ (reprint author), US Army, Engn Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA.
EM Alan.J.Kennedy@usace.army.mil
FU U.S. Army Environmental Quality Research Program
FX Research was funded by the U.S. Army Environmental Quality Research
Program (Dr. Elizabeth Ferguson). Permission was granted by the Chief of
Engineers to publish this information. We thank Dr. Christopher Detzel
(NanoSafe) and Ms. Ashley Harmon (ERDC) for TEM analysis.
NR 73
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U1 4
U2 29
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
EI 1520-5851
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD OCT 20
PY 2015
VL 49
IS 20
BP 12490
EP 12499
DI 10.1021/acs.est.5b03291
PG 10
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA CU2JB
UT WOS:000363348700058
PM 26375160
ER
PT J
AU Klangthong, K
Promsthaporn, S
Leepitakrat, S
Schuster, AL
McCardle, PW
Kosoy, M
Takhampunya, R
AF Klangthong, Kewalin
Promsthaporn, Sommai
Leepitakrat, Surachai
Schuster, Anthony L.
McCardle, Patrick W.
Kosoy, Michael
Takhampunya, Ratree
TI The Distribution and Diversity of Bartonella Species in Rodents and
Their Ectoparasites across Thailand
SO PLOS ONE
LA English
DT Article
ID MOLECULAR-DETECTION; ANIMAL RESERVOIRS; MAMMALIAN HOSTS; SPP.;
INFECTIONS; PREVALENCE; DNA; DIFFERENTIATION; IDENTIFICATION;
PATHOGENICITY
AB Our study highlights the surveillance of Bartonella species among rodents and their associated ectoparasites (ticks, fleas, lice, and mites) in several regions across Thailand. A total of 619 rodents and 554 pooled ectoparasites (287 mite pools, 62 flea pools, 35 louse pools, and 170 tick pools) were collected from 8 provinces within 4 regions of Thailand. Bandicota indica (279), Rattus rattus (163), and R. exulans (96) were the most prevalent species of rats collected in this study. Real-time PCR assay targeting Bartonella-specific ssrA gene was used for screening and each positive sample was confirmed by PCR using nuoG gene. The prevalence of Bartonella DNA in rodent (around 17%) was recorded in all regions. The highest prevalence of Bartonella species was found in B. savilei and R. rattus with the rate of 35.7% (5/14) and 32.5%(53/163), respectively. High prevalence of Bartonella-positive rodent was also found in B. indica (15.1%, 42/279), and R. norvegicus (12.5%, 5/40). In contrast, the prevalence of Bartonella species in ectoparasites collected from the rats varied significantly according to types of ectoparasites. A high prevalence of Bartonella DNA was found in louse pools (Polyplax spp. and Hoplopleura spp., 57.1%) and flea pools (Xenopsylla cheopis, 25.8%), while a low prevalence was found in pools of mites (Leptotrombidium spp. and Ascoschoengastia spp., 1.7%) and ticks (Haemaphysalis spp., 3.5%). Prevalence of Bartonella DNA in ectoparasites collected from Bartonella-positive rodents (19.4%) was significantly higher comparing to ectoparasites from Bartonella-negative rodents (8.7%). The phylogenetic analysis of 41 gltA sequences of 16 Bartonella isolates from rodent blood and 25 Bartonella-positive ectoparasites revealed a wide range of diversity among Bartonella species with a majority of sequences (61.0%) belonging to Bartonella elizabethae complex (11 rodents, 1 mite pool, and 5 louse pools), while the remaining sequences were identical to B. phoceensis (17.1%, 1 mite pool, 5 louse pools, and 1 tick pool), B. coopersplainensis (19.5%, 5 rodents, 1 louse pool, and 2 tick pools), and one previously unidentified Bartonella species (2.4%, 1 louse pool).
C1 [Klangthong, Kewalin; Promsthaporn, Sommai; Leepitakrat, Surachai; Schuster, Anthony L.; McCardle, Patrick W.; Takhampunya, Ratree] Armed Forces Res Inst Med Sci, US Army Med Directorate, Dept Entomol, Bangkok 10400, Thailand.
[Kosoy, Michael] Ctr Dis Control & Prevent, Div Vector Borne Dis, Ft Collins, CO USA.
RP Takhampunya, R (reprint author), Armed Forces Res Inst Med Sci, US Army Med Directorate, Dept Entomol, Bangkok 10400, Thailand.
EM RatreeT.fsn@afrims.org
FU Department of Defense Global Emerging Infections Surveillance and
Response System (GEIS)
FX This work has been supported by the Department of Defense Global
Emerging Infections Surveillance and Response System (GEIS,
https://www.afhsc.mil/Home/Divisions/GEIS). The funder had no role in
study design, data collection and analysis, decision to publish, or
preparation of the manuscript.
NR 38
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U1 2
U2 7
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD OCT 20
PY 2015
VL 10
IS 10
AR e0140856
DI 10.1371/journal.pone.0140856
PG 16
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CT7XI
UT WOS:000363028100080
PM 26484537
ER
PT J
AU Xie, KY
An, Q
Toksoy, MF
McCauley, JW
Haber, RA
Goddard, WA
Hemker, KJ
AF Xie, Kelvin Y.
An, Qi
Toksoy, M. Fatih
McCauley, James W.
Haber, Richard A.
Goddard, William A., III
Hemker, Kevin J.
TI Atomic-Level Understanding of "Asymmetric Twins" in Boron Carbide
SO PHYSICAL REVIEW LETTERS
LA English
DT Article
ID STRENGTH; NITRIDE; COPPER
AB Recent observations of planar defects in boron carbide have been shown to deviate from perfect mirror symmetry and are referred to as "asymmetric twins." Here, we demonstrate that these asymmetric twins are really phase boundaries that form in stoichiometric B4C (i.e., B12C3) but not in B13C2. TEM observations and ab initio simulations have been coupled to show that these planar defects result from an interplay of stoichiometry, atomic positioning, icosahedral twinning, and structural hierarchy. The composition of icosahedra in B4C is B11C and translation of the carbon atom from a polar to equatorial site leads to a shift in bonding and a slight distortion of the lattice. No such distortion is observed in boron-rich B13C2 because the icosahedra do not contain carbon. Implications for tailoring boron carbide with stoichiometry and extrapolations to other hierarchical crystalline materials are discussed.
C1 [Xie, Kelvin Y.; McCauley, James W.; Hemker, Kevin J.] Johns Hopkins Univ, Dept Mech Engn, Baltimore, MD 21218 USA.
[An, Qi; Goddard, William A., III] CALTECH, Mat & Proc Simulat Ctr, Pasadena, CA 91125 USA.
[Toksoy, M. Fatih; Haber, Richard A.] Rutgers State Univ, Ceram & Composite Mat Ctr, Piscataway, NJ 08854 USA.
[McCauley, James W.] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RP Hemker, KJ (reprint author), Johns Hopkins Univ, Dept Mech Engn, Baltimore, MD 21218 USA.
EM hemker@jhu.edu
RI Xie, Kelvin/M-2248-2016
OI Xie, Kelvin/0000-0001-8675-5321
FU Army Research Laboratory [W911NF-12-2-0022]; Defense Advanced Research
Projects Agency [W31P4Q-13-1-0010]; National Science Foundation
[DMR-1436985]
FX This research was sponsored by the Army Research Laboratory and was
accomplished under Cooperative Agreement No. W911NF-12-2-0022. In
addition, Q. A. and W. A. G. also received support from the Defense
Advanced Research Projects Agency (W31P4Q-13-1-0010, program manager,
Judah Goldwasser), and the National Science Foundation (DMR-1436985).
The views and conclusions contained in this document are those of the
authors and should not be interpreted as representing the official
policies, either expressed or implied, of the Army Research Laboratory
or the U.S. Government. "The U.S. Government retains and the publisher,
by accepting the paper for publication, acknowledges that the U.S.
Government retains a nonexclusive, paid-up, irrevocable, world-wide
license to publish or reproduce the published form of this manuscript,
or allow others to do so, for U.S. Government purposes."
NR 22
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U1 8
U2 34
PU AMER PHYSICAL SOC
PI COLLEGE PK
PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA
SN 0031-9007
EI 1079-7114
J9 PHYS REV LETT
JI Phys. Rev. Lett.
PD OCT 20
PY 2015
VL 115
IS 17
AR 175501
DI 10.1103/PhysRevLett.115.175501
PG 5
WC Physics, Multidisciplinary
SC Physics
GA CT7VX
UT WOS:000363023700010
PM 26551123
ER
PT J
AU van Panhuis, WG
Choisy, M
Xiong, X
Chok, NS
Akarasewi, P
Iamsirithaworn, S
Lam, SK
Chong, CK
Lam, FC
Phommasak, B
Vongphrachanh, P
Bouaphanh, K
Rekol, H
Hien, NT
Thai, PQ
Duong, TN
Chuang, JH
Liu, YL
Ng, LC
Shi, Y
Tayag, EA
Roque, VG
Suy, LLL
Jarman, RG
Gibbons, RV
Velasco, JMS
Yoon, IK
Burke, DS
Cummings, DAT
AF van Panhuis, Willem G.
Choisy, Marc
Xiong, Xin
Chok, Nian Shong
Akarasewi, Pasakorn
Iamsirithaworn, Sopon
Lam, Sai K.
Chong, Chee K.
Lam, Fook C.
Phommasak, Bounlay
Vongphrachanh, Phengta
Bouaphanh, Khamphaphongphane
Rekol, Huy
Nguyen Tran Hien
Pham Quang Thai
Tran Nhu Duong
Chuang, Jen-Hsiang
Liu, Yu-Lun
Ng, Lee-Ching
Shi, Yuan
Tayag, Enrique A.
Roque, Vito G., Jr.
Suy, Lyndon L. Lee
Jarman, Richard G.
Gibbons, Robert V.
Velasco, John Mark S.
Yoon, In-Kyu
Burke, Donald S.
Cummings, Derek A. T.
TI Region-wide synchrony and traveling waves of dengue across eight
countries in Southeast Asia
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
AMERICA
LA English
DT Article
DE dengue; epidemiology; surveillance data; Southeast Asia; dynamics
ID TIME-SERIES; SPATIAL HIERARCHIES; EL-NINO; VIRUSES; EPIDEMIOLOGY;
PHILIPPINES; EMERGENCE; EVOLUTION; PERTUSSIS; GENOTYPE
AB Dengue is a mosquito-transmitted virus infection that causes epidemics of febrile illness and hemorrhagic fever across the tropics and subtropics worldwide. Annual epidemics are commonly observed, but there is substantial spatiotemporal heterogeneity in intensity. A better understanding of this heterogeneity in dengue transmission could lead to improved epidemic prediction and disease control. Time series decomposition methods enable the isolation and study of temporal epidemic dynamics with a specific periodicity (e.g., annual cycles related to climatic drivers and multiannual cycles caused by dynamics in population immunity). We collected and analyzed up to 18 y of monthly dengue surveillance reports on a total of 3.5 million reported dengue cases from 273 provinces in eight countries in Southeast Asia, covering similar to 10(7) km(2). We detected strong patterns of synchronous dengue transmission across the entire region, most markedly during a period of high incidence in 1997-1998, which was followed by a period of extremely low incidence in 2001-2002. This synchrony in dengue incidence coincided with elevated temperatures throughout the region in 1997-1998 and the strongest El NiNo episode of the century. Multiannual dengue cycles (2-5 y) were highly coherent with the Oceanic NiNo Index, and synchrony of these cycles increased with temperature. We also detected localized traveling waves of multiannual dengue epidemic cycles in Thailand, Laos, and the Philippines that were dependent on temperature. This study reveals forcing mechanisms that drive synchronization of dengue epidemics on a continental scale across Southeast Asia.
C1 [van Panhuis, Willem G.; Xiong, Xin; Chok, Nian Shong; Burke, Donald S.] Univ Pittsburgh, Dept Epidemiol, Grad Sch Publ Hlth, Pittsburgh, PA 15261 USA.
[Choisy, Marc] Univ Montpellier, Inst Rech Dev Montpellier, Lab Malad Infect & Vecteurs Ecol Genet Evolut Ct, Ctr Natl Rech Sci,Inst Rech Dev,Unite Mixte Rech, F-34394 Montpellier, France.
[Choisy, Marc] Univ Oxford, Clin Res Unit, Wellcome Trust Major Overseas Programme, Natl Hosp Trop Dis, Hanoi 100000, Vietnam.
[Akarasewi, Pasakorn; Iamsirithaworn, Sopon] Thailand Minist Publ Hlth, Bur Epidemiol, Bangkok 10220, Thailand.
[Lam, Sai K.] Univ Malaya, High Impact Res, Kuala Lumpur 50603, Malaysia.
[Chong, Chee K.] Malaysia Minist Hlth, Dis Control Div, Putrajaya 62590, Malaysia.
[Lam, Fook C.] Worthing Dist Hosp, Western Sussex Hosp Natl Hlth Serv Trust, W Sussex BN11 2DH, England.
[Phommasak, Bounlay] Minist Hlth, Dept Communicable Dis Control, Viangchan 0100, Laos.
[Vongphrachanh, Phengta; Bouaphanh, Khamphaphongphane] Minist Hlth, Natl Ctr Lab & Epidemiol, Viangchan 0100, Laos.
[Rekol, Huy] Cambodia Minist Hlth, Natl Dengue Control Program, Phnom Penh 12000, Cambodia.
[Nguyen Tran Hien; Pham Quang Thai; Tran Nhu Duong] Vietnam Natl Inst Hyg & Epidemiol, Dept Epidemiol, Hanoi 100000, Vietnam.
[Chuang, Jen-Hsiang; Liu, Yu-Lun] Taiwan Minist Hlth & Welf, Ctr Dis Control, Taipei 10050, Taiwan.
[Ng, Lee-Ching; Shi, Yuan] Singapore Natl Environm Agcy, Environm Hlth Inst, Singapore 228231, Singapore.
[Tayag, Enrique A.; Roque, Vito G., Jr.] Philippines Dept Hlth, Natl Epidemiol Ctr, Manila 1003, Philippines.
[Suy, Lyndon L. Lee] Philippines Dept Hlth, Natl Ctr Dis Prevent & Control, Manila 1003, Philippines.
[Jarman, Richard G.] Walter Reed Army Inst Res, Viral Dis Branch, Silver Spring, MD 20910 USA.
[Gibbons, Robert V.; Velasco, John Mark S.] US Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand.
[Yoon, In-Kyu] Int Vaccine Inst, Dengue Vaccine Initiat, Seoul 08826, South Korea.
[Cummings, Derek A. T.] Univ Florida, Dept Biol, Gainesville, FL 32610 USA.
[Cummings, Derek A. T.] Univ Florida, Emerging Pathogens Inst, Gainesville, FL 32610 USA.
RP van Panhuis, WG (reprint author), Univ Pittsburgh, Dept Epidemiol, Grad Sch Publ Hlth, Pittsburgh, PA 15261 USA.
EM wav10@pitt.edu
RI LAM, SAI KIT/B-5231-2010; Choisy, Marc/J-7131-2016;
OI Choisy, Marc/0000-0002-5187-6390; Chuang,
Jen-Hsiang/0000-0002-7114-3418; /0000-0002-5704-8094
FU Bill and Melinda Gates Foundation [49276]; US National Institute of
General Medical Sciences [5U54GM088491]; University of Malaya
[UM.C/HIR/MOHE/CHAN/15]; Career Award at the Scientific Interface from
the Burroughs Wellcome Fund; US NIH [R01AI102939, R01AI114703]
FX The authors thank surveillance data managers in each country for support
in compiling dengue surveillance data. We also thank Dr. Nyphonh (Lao
People's Democratic Republic), Ms. Hannah Lewis (WHO), Dr. Torreton
(Institut de Recherche pour le Developpement, Vietnam), and Dr. Sok
Touch (CDC Cambodia) for support in facilitating collaborations and Mr.
Guido Camargo for proofreading of this manuscript. W.G.v.P., D.A.T.C.,
X.X., N.S.C., M.C., and D.S.B. would like to thank the Bill and Melinda
Gates Foundation (Grant 49276, Evaluation of Candidate Vaccine
Technologies Using Computational Models) and the US National Institute
of General Medical Sciences (Grant 5U54GM088491, Computational Models of
Infectious Disease Threats) for their support. S.K.L. would like to
thank the University of Malaya for their support
(UM.C/HIR/MOHE/CHAN/15). M.C. would like to thank the Groupe de
Recherche International (GDRI) "Biodiversity and infectious diseases in
Southeast Asia." D.A.T.C. was funded by a Career Award at the Scientific
Interface from the Burroughs Wellcome Fund and the US NIH R01AI102939
and R01AI114703.
NR 33
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Z9 11
U1 4
U2 19
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD OCT 20
PY 2015
VL 112
IS 42
BP 13069
EP 13074
DI 10.1073/pnas.1501375112
PG 6
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CT9LN
UT WOS:000363138600050
PM 26438851
ER
PT J
AU Sharma, D
Motayed, A
Shah, PB
Amani, M
Georgieva, M
Birdwell, AG
Dubey, M
Li, QL
Davydov, AV
AF Sharma, Deepak
Motayed, Abhishek
Shah, Pankaj B.
Amani, Matin
Georgieva, Mariela
Birdwell, A. Glen
Dubey, Madan
Li, Qiliang
Davydov, Albert V.
TI Transfer characteristics and low-frequency noise in single-and
multi-layer MoS2 field-effect transistors
SO APPLIED PHYSICS LETTERS
LA English
DT Article
ID INTEGRATED-CIRCUITS; LAYER MOS2
AB Leveraging nanoscale field-effect transistors (FETs) in integrated circuits depends heavily on its transfer characteristics and low-frequency noise (LFN) properties. Here, we report the transfer characteristics and LFN in FETs fabricated with molybdenum disulfide (MoS2) with different layer (L) counts. 4L to 6L devices showed highest ION-IOFF ratio (approximate to 10(8)) whereas LFN was maximum for 1L device with normalized power spectral density (PSD) approximate to 1.5 x 10(-5) Hz(-1). For devices with L approximate to 6, PSD was minimum (approximate to 2 x10(-8) Hz(-1)). Further, LFN for single and few layer devices satisfied carrier number fluctuation (CNF) model in both weak and strong accumulation regimes while thicker devices followed Hooge's mobility fluctuation model in the weak accumulation regime and CNF model in strong accumulation regime, respectively. Transfer-characteristics and LFN experimental data are explained with the help of model incorporating Thomas-Fermi charge screening and inter-layer resistance coupling. (C) 2015 AIP Publishing LLC.
C1 [Sharma, Deepak; Motayed, Abhishek; Davydov, Albert V.] NIST, Mat Measurement Lab, Gaithersburg, MD 20899 USA.
[Sharma, Deepak] Theiss Res Inc, La Jolla, CA 92037 USA.
[Sharma, Deepak; Li, Qiliang] George Mason Univ, Dept Elect & Comp Engn, Fairfax, VA 22030 USA.
[Motayed, Abhishek] Univ Maryland, IREAP, College Pk, MD 20742 USA.
[Shah, Pankaj B.; Amani, Matin; Georgieva, Mariela; Birdwell, A. Glen; Dubey, Madan] US Army, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA.
RP Sharma, D (reprint author), NIST, Mat Measurement Lab, Gaithersburg, MD 20899 USA.
FU Material Genome Initiative; ARL Director's Strategic Initiative program
on interfaces in stacked 2D atomic layered materials
FX D.S. and A.V.D. acknowledge the support of Material Genome Initiative
funding allocated to NIST; P.B.S., M.G., M.A., A.G.B., and M.D.
acknowledge the support of the ARL Director's Strategic Initiative
program on interfaces in stacked 2D atomic layered materials. The views
and conclusions contained in this document are those of the authors and
should not be interpreted as representing the official policies, either
expressed or implied, of the ARL or the U.S. Government. The U.S.
Government is authorized to reproduce or distribute reprints for
Government purposes notwithstanding any copyright notation herein.
NR 30
TC 0
Z9 0
U1 4
U2 21
PU AMER INST PHYSICS
PI MELVILLE
PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA
SN 0003-6951
EI 1077-3118
J9 APPL PHYS LETT
JI Appl. Phys. Lett.
PD OCT 19
PY 2015
VL 107
IS 16
AR 162102
DI 10.1063/1.4932945
PG 5
WC Physics, Applied
SC Physics
GA CU8HG
UT WOS:000363781900011
ER
PT J
AU Ganju, NK
Kirwan, ML
Dickhudt, PJ
Guntenspergen, GR
Cahoon, DR
Kroeger, KD
AF Ganju, Neil K.
Kirwan, Matthew L.
Dickhudt, Patrick J.
Guntenspergen, Glenn R.
Cahoon, Donald R.
Kroeger, Kevin D.
TI Sediment transport-based metrics of wetland stability
SO GEOPHYSICAL RESEARCH LETTERS
LA English
DT Article
DE sediment transport; tidal wetlands; wetland stability; wetland
vulnerability
ID SEA-LEVEL RISE; SALT-MARSH; CHESAPEAKE BAY; TIDAL MARSH; BRACKISH MARSH;
ESTUARY; MODEL; WATER; FLUX; ACCRETION
AB Despite the importance of sediment availability on wetland stability, vulnerability assessments seldom consider spatiotemporal variability of sediment transport. Models predict that the maximum rate of sea level rise a marsh can survive is proportional to suspended sediment concentration (SSC) and accretion. In contrast, we find that SSC and accretion are higher in an unstable marsh than in an adjacent stable marsh, suggesting that these metrics cannot describe wetland vulnerability. Therefore, we propose the flood/ebb SSC differential and organic-inorganic suspended sediment ratio as better vulnerability metrics. The unstable marsh favors sediment export (18mgL(-1) higher on ebb tides), while the stable marsh imports sediment (12mgL(-1) higher on flood tides). The organic-inorganic SSC ratio is 84% higher in the unstable marsh, and stable isotopes indicate a source consistent with marsh-derived material. These simple metrics scale with sediment fluxes, integrate spatiotemporal variability, and indicate sediment sources.
C1 [Ganju, Neil K.; Kroeger, Kevin D.] US Geol Survey, Woods Hole Coastal & Marine Sci Ctr, Woods Hole, MA 02543 USA.
[Kirwan, Matthew L.] Virginia Inst Marine Sci, Coll William & Mary, Gloucester Point, VA 23062 USA.
[Dickhudt, Patrick J.] US Army Engineer Res & Dev Ctr, Coastal & Hydraul Lab, Duck, NC USA.
[Guntenspergen, Glenn R.; Cahoon, Donald R.] US Geol Survey, Patuxent Wildlife Res Ctr, Beltsville, MD USA.
RP Ganju, NK (reprint author), US Geol Survey, Woods Hole Coastal & Marine Sci Ctr, Woods Hole, MA 02543 USA.
EM nganju@usgs.gov
OI Kroeger, Kevin/0000-0002-4272-2349; Ganju, Neil/0000-0002-1096-0465
FU U.S. Geological Survey Coastal and Marine Geology Program; Global Change
and Land Use Program
FX The time series data are available from the USGS Oceanographic Time
Series Database at http://stellwagen.er.usgs.gov/bw2011.html. Wally
Brooks, Jon Borden, Ellyn Montgomery, Sandy Brosnahan, R. Kyle Derby,
Patrick Brennand, and Nick Nidzieko provided assistance with site
access, data collection, and data processing. We thank Sergio Fagherazzi
and an anonymous reviewer for their insightful suggestions which greatly
improved the manuscript. Funding was provided by the U.S. Geological
Survey Coastal and Marine Geology Program and Global Change and Land Use
Program. Use of brand names is for identification purposes only and does
not constitute endorsement by the U.S. Government.
NR 55
TC 9
Z9 9
U1 1
U2 30
PU AMER GEOPHYSICAL UNION
PI WASHINGTON
PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA
SN 0094-8276
EI 1944-8007
J9 GEOPHYS RES LETT
JI Geophys. Res. Lett.
PD OCT 16
PY 2015
VL 42
IS 19
BP 7992
EP 8000
DI 10.1002/2015GL065980
PG 9
WC Geosciences, Multidisciplinary
SC Geology
GA CU7DF
UT WOS:000363695500018
ER
PT J
AU Arntsen, AE
Song, AJ
Perovich, DK
Richter-Menge, JA
AF Arntsen, Alexandra E.
Song, Arnold J.
Perovich, Donald K.
Richter-Menge, Jacqueline A.
TI Observations of the summer breakup of an Arctic sea ice cover
SO GEOPHYSICAL RESEARCH LETTERS
LA English
DT Article
DE sea ice; floe size distribution; breakup
ID FLOE-SIZE DISTRIBUTION; OCEAN; MORPHOLOGY; STORM
AB The Arctic sea ice cover evolves dramatically through the summer melt season. Floe size distribution (FSD) is a critical parameter used to examine this change as the ice cover transitions from large rectilinear plates in spring to an ensemble of discrete rounded floes by midsummer. The FSD at a given time impacts the dynamic and thermodynamic behavior of the ice cover. Focusing on the seasonal marginal ice zone in the Beaufort and Chukchi Seas from May to September 2014, we present qualitative and quantitative results derived from National Technical Means high-resolution imagery and supported by ice mass balance buoy data. Results indicate that as melt accelerates, floe breaking pattern, and therefore FSD, is heavily influenced by the distribution of melt ponds. Discrete element model results using morphological conditions derived from analyzed satellite imagery confirmed that breaking occurs along ponds and perpendicular to applied stress.
C1 [Arntsen, Alexandra E.; Perovich, Donald K.; Richter-Menge, Jacqueline A.] Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA.
[Song, Arnold J.; Perovich, Donald K.; Richter-Menge, Jacqueline A.] ERDC CRREL, Hanover, NH USA.
RP Arntsen, AE (reprint author), Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA.
EM Alexandra.E.Arntsen.TH@dartmouth.edu
FU Office of Naval Research [N000141410176, N0001413MP20163]; National
Science Foundation Arctic Observing Network [NSF- 0856376]
FX The NTM images are available at htt://gfl.usgs.gov/.IMB; results can be
found at http://imb.erdc.dren.mil/. This study was supported by the
Office of Naval Research under awards N000141410176 and N0001413MP20163
and also by the National Science Foundation Arctic Observing Network
(NSF- 0856376).
NR 32
TC 1
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U1 4
U2 14
PU AMER GEOPHYSICAL UNION
PI WASHINGTON
PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA
SN 0094-8276
EI 1944-8007
J9 GEOPHYS RES LETT
JI Geophys. Res. Lett.
PD OCT 16
PY 2015
VL 42
IS 19
BP 8057
EP 8063
DI 10.1002/2015GL065224
PG 7
WC Geosciences, Multidisciplinary
SC Geology
GA CU7DF
UT WOS:000363695500025
ER
PT J
AU Clifford, JL
Mares, A
Hansen, J
Averitt, DL
AF Clifford, John L.
Mares, Alberto
Hansen, Jacob
Averitt, Dayna L.
TI Preemptive perineural bupivacaine attenuates the maintenance of
mechanical and cold allodynia in a rat spinal nerve ligation model
SO BMC ANESTHESIOLOGY
LA English
DT Article
DE Neuropathic; Pain; Allodynia; Hyperalgesia; Bupivacaine; Preemptive
ID EXPERIMENTAL LUMBAR RADICULOPATHY; RANDOMIZED CONTROLLED-TRIAL; REDUCES
POSTOPERATIVE PAIN; NEUROPATHIC PAIN; PERIPHERAL-NERVE; POSTHERPETIC
NEURALGIA; TACTILE ALLODYNIA; ROOT IRRITATION; IRAQI FREEDOM;
DOUBLE-BLIND
AB Background: Neuropathic pain is evasive to treat once developed, however evidence suggests that local administration of anesthetics near the time of injury reduces the development of neuropathic pain. As abnormal electrical signaling in the damaged nerve contributes to the initiation and maintenance of neuropathic pain, local administration of anesthetics prior to injury may reduce its development. We hypothesized that local treatment with bupivacaine prior to nerve injury in a rat model of spinal nerve ligation (SNL) would attenuate the initiation and/or maintenance of neuropathic pain behaviors.
Methods: On the day prior to SNL, baseline measures of pre-injury mechanical, thermal, and/or cold sensitivity were recorded in adult male Sprague-Dawley rats. Immediately prior to SNL or sham treatment, the right L5 nerve was perineurally bathed in either 0.05 mL bupivacaine (0.5 %) or sterile saline (0.9 %) for 30 min. Mechanical allodynia, thermal hyperalgesia, and/or cold allodynia were then examined at 3, 7, 10, 14 and 21 days following SNL.
Results: Rats exhibited both mechanical and cold allodynia, but not thermal hyperalgesia, within 3 days and up to 21 days post-SNL. No significant pain behaviors were observed in sham controls. Preemptive local bupivacaine significantly attenuated both mechanical and cold allodynia as early as 10 days following SNL compared to saline controls and were not significantly different from sham controls.
Conclusions: These data indicate that local treatment with bupivacaine prior to surgical manipulations that are known to cause nerve damage may protect against the maintenance of chronic neuropathic pain.
C1 [Clifford, John L.; Mares, Alberto; Hansen, Jacob] US Army Inst Surg Res, Pain Management Res Area, Ft Sam Houston, TX USA.
[Averitt, Dayna L.] Texas Womans Univ, Dept Biol, Denton, TX 76204 USA.
RP Averitt, DL (reprint author), Texas Womans Univ, Dept Biol, POB 425799, Denton, TX 76204 USA.
EM daveritt@twu.edu
OI Averitt, Dayna/0000-0001-8345-4988
FU United States Army Medical Research and Material Command Casualty Care
Research Program; Clinical and Rehabilitative Medicine Research Program
FX We would like to acknowledge Bopaiah Cheppudira, Ph.D., Helen Arizpe,
M.S., Alex Trevino, Jessica Hayden, M.S. and Angie Greer for technical
assistance. We also acknowledge Jay Aiden for statistical analysis
assistance. We thank Drs. Lawrence Petz and Marcie Fowler for helpful
comments on study design. This work was supported by the United States
Army Medical Research and Material Command Casualty Care Research
Program and the Clinical and Rehabilitative Medicine Research Program.
NR 59
TC 0
Z9 0
U1 2
U2 5
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2253
J9 BMC ANESTHESIOL
JI BMC Anesthesiol.
PD OCT 16
PY 2015
VL 15
AR 135
DI 10.1186/s12871-015-0113-x
PG 9
WC Anesthesiology
SC Anesthesiology
GA CT9CN
UT WOS:000363113700004
PM 26444970
ER
PT J
AU Pasiakos, SM
McClung, HL
Margolis, LM
Murphy, NE
Lin, GG
Hydren, JR
Young, AJ
AF Pasiakos, Stefan M.
McClung, Holly L.
Margolis, Lee M.
Murphy, Nancy E.
Lin, Gregory G.
Hydren, Jay R.
Young, Andrew J.
TI Human Muscle Protein Synthetic Responses during Weight-Bearing and
Non-Weight-Bearing Exercise: A Comparative Study of Exercise Modes and
Recovery Nutrition
SO PLOS ONE
LA English
DT Article
ID SIGNALING MOLECULE PHOSPHORYLATION; RESISTANCE EXERCISE; ENDURANCE
EXERCISE; SKELETAL-MUSCLE; YOUNG MEN; ENERGY-BALANCE; LOAD CARRIAGE;
OLDER MEN; MYOFIBRILLAR; INGESTION
AB Effects of conventional endurance (CE) exercise and essential amino acid (EAA) supplementation on protein turnover are well described. Protein turnover responses to weighted endurance exercise (i.e., load carriage, LC) and EAA may differ from CE, because the mechanical forces and contractile properties of LC and CE likely differ. This study examined muscle protein synthesis (MPS) and whole-body protein turnover in response to LC and CE, with and without EAA supplementation, using stable isotope amino acid tracer infusions. Forty adults (mean +/- SD, 22 +/- 4 y, 80 +/- 10 kg, VO2peak 4.0 +/- 0.5 L.min(-1)) were randomly assigned to perform 90 min, absolute intensity-matched (2.2 +/- 0.1 VO2 L.m(-1)) LC (performed on a treadmill wearing a vest equal to 30% of individual body mass, mean +/- SD load carried 24 +/- 3 kg) or CE (cycle ergometry performed at the same absolute VO2 as LC) exercise, during which EAA (10 g EAA, 3.6 g leucine) or control (CON, non-nutritive) drinks were consumed. Mixed-muscle and myofibrillar MPS were higher during exercise for LC than CE (mode main effect, P < 0.05), independent of dietary treatment. EAA enhanced mixed-muscle and sarcoplasmic MPS during exercise, regardless of mode (drink main effect, P < 0.05). Mixed-muscle and sarcoplasmic MPS were higher in recovery for LC than CE (mode main effect, P < 0.05). No other differences or interactions (mode x drink) were observed. However, EAA attenuated whole-body protein breakdown, increased amino acid oxidation, and enhanced net protein balance in recovery compared to CON, regardless of exercise mode (P < 0.05). These data show that, although whole-body protein turnover responses to absolute VO2-matched LC and CE are the same, LC elicited a greater muscle protein synthetic response than CE.
C1 [Pasiakos, Stefan M.; McClung, Holly L.; Margolis, Lee M.; Murphy, Nancy E.; Lin, Gregory G.; Young, Andrew J.] US Army Res Inst Environm Med, Mil Nutr Div, Natick, MA 01760 USA.
[Hydren, Jay R.] US Army Res Inst Environm Med, Mil Performance Div, Natick, MA USA.
RP Pasiakos, SM (reprint author), US Army Res Inst Environm Med, Mil Nutr Div, Natick, MA 01760 USA.
EM stefan.m.pasiakos.civ@mail.mil
RI Pasiakos, Stefan/E-6295-2014; Hydren, Jay/H-3654-2016;
OI Pasiakos, Stefan/0000-0002-5378-5820; Hydren, Jay/0000-0001-9385-8898; ,
Lee/0000-0002-0652-1304
FU US Army Medical Research and Materiel Command; US Army Natick Soldier
Research Development and Engineering Center
FX The study was funded by the US Army Medical Research and Materiel
Command and the US Army Natick Soldier Research Development and
Engineering Center.
NR 38
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Z9 1
U1 1
U2 3
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD OCT 16
PY 2015
VL 10
IS 10
AR e0140863
DI 10.1371/journal.pone.0140863
PG 16
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CU0DF
UT WOS:000363185500121
PM 26474292
ER
PT J
AU McComb, JQ
Han, FXX
Rogers, C
Thomas, C
Arslan, Z
Ardeshir, A
Tchounwou, PB
AF McComb, Jacqueline Q.
Han, Fengxiang X.
Rogers, Christian
Thomas, Catherine
Arslan, Zikri
Ardeshir, Adeli
Tchounwou, Paul B.
TI Trace elements and heavy metals in the Grand Bay National Estuarine
Reserve in the northern Gulf of Mexico
SO MARINE POLLUTION BULLETIN
LA English
DT Article
DE Environmental impact; Estuarine chemistry; Trace elements;
Biogeochemical process; Lead isotopes; Grand Bay Reserve
ID ARID-ZONE SOILS; SEDIMENTS; PHOSPHORUS; ISOTOPES; MOBILITY; COBALT;
WATER; LEAD
AB The objectives of this study are to investigate distribution of trace elements and heavy metals in the salt marsh and wetland soil and biogeochemical processes in the Grand Bay National Estuarine Research Reserve of the northern Gulf of Mexico. The results show that Hg, Cd and to some extent, As and Pb have been significantly accumulated in soils. The strongest correlations were found between concentrations of Ni and total organic matter contents. The correlations decreased in the order: Ni > Cr > Sr > Co > Zn, Cd > Cu > Cs. Strong correlations were also observed between total P and concentrations of Ni, Co, Cr, Sr, Zn, Cu, and Cd. This may be related to the P spilling accident in 2005 in the Bangs Lake site. Lead isotopic ratios in soils matched well those of North American coals, indicating the contribution of Pb through atmospheric fallout from coal power plants. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [McComb, Jacqueline Q.; Han, Fengxiang X.; Rogers, Christian; Tchounwou, Paul B.] Jackson State Univ, Environm PhD Sci, Jackson, MS 39217 USA.
[Han, Fengxiang X.; Arslan, Zikri] Jackson State Univ, Dept Chem & Biochem, Jackson, MS 39217 USA.
[Thomas, Catherine] US Army Engineer Res & Dev Ctr ERDC, Vicksburg, MS 39180 USA.
[Ardeshir, Adeli] USDA ARS, Genet & Precis Agr Res Unit, Mississippi State, MS 39762 USA.
RP Han, FXX (reprint author), Jackson State Univ, Environm PhD Sci, 1400 JR Lynch St, Jackson, MS 39217 USA.
EM Fengxiang.han@jsums.edu
FU U.S. Nuclear Regulatory Commission - United States
[NRC-HQ-12-G-38-0038]; U.S. Department of Commerce (NOAA) - United
States [NA11SEC4810001-003499]; National Institutes of Health NIMHD-RCMI
- United States [G12MD007581]
FX This research was supported by U.S. Nuclear Regulatory Commission -
United States (NRC-HQ-12-G-38-0038), U.S. Department of Commerce (NOAA)
- United States (NA11SEC4810001-003499), and National Institutes of
Health NIMHD-RCMI - United States (G12MD007581).
NR 37
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Z9 3
U1 3
U2 29
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0025-326X
EI 1879-3363
J9 MAR POLLUT BULL
JI Mar. Pollut. Bull.
PD OCT 15
PY 2015
VL 99
IS 1-2
BP 61
EP 69
DI 10.1016/j.marpolbul.2015.07.062
PG 9
WC Environmental Sciences; Marine & Freshwater Biology
SC Environmental Sciences & Ecology; Marine & Freshwater Biology
GA CV4SY
UT WOS:000364258000018
PM 26238403
ER
PT J
AU Dominique, JK
Ortiz-Osorno, AA
Fitzgibbon, J
Gnanashanmugam, D
Gilpin, C
Tucker, T
Peel, S
Peter, T
Kim, P
Smith, S
AF Dominique, Joyelle K.
Ortiz-Osorno, Alberto A.
Fitzgibbon, Joseph
Gnanashanmugam, Devasena
Gilpin, Christopher
Tucker, Timothy
Peel, Sheila
Peter, Trevor
Kim, Peter
Smith, Steven
TI Implementation of HIV and Tuberculosis Diagnostics: The Importance of
Context
SO CLINICAL INFECTIOUS DISEASES
LA English
DT Article
DE diagnostics; HIV; tuberculosis; diagnostics' implementation;
point-of-care
ID RESOURCE-LIMITED SETTINGS; XPERT MTB/RIF; ANTIRETROVIRAL THERAPY;
COST-EFFECTIVENESS; DEVELOPING-COUNTRIES; HEALTH SYSTEMS; RURAL UGANDA;
CARE; AFRICA; TESTS
AB Background. Novel diagnostics have been widely applied across human immunodeficiency virus (HIV) and tuberculosis prevention and treatment programs. To achieve the greatest impact, HIV and tuberculosis diagnostic programs must carefully plan and implement within the context of a specific healthcare system and the laboratory capacity.
Methods. A workshop was convened in Cape Town in September 2014. Participants included experts from laboratory and clinical practices, officials from ministries of health, and representatives from industry.
Results. The article summarizes best practices, challenges, and lessons learned from implementation experiences across sub-Saharan Africa for (1) building laboratory programs within the context of a healthcare system; (2) utilizing experience of clinicians and healthcare partners in planning and implementing the right diagnostic; and (3) evaluating the effects of new diagnostics on the healthcare system and on patient health outcomes.
Conclusions. The successful implementation of HIV and tuberculosis diagnostics in resource-limited settings relies on careful consideration of each specific context.
C1 [Dominique, Joyelle K.] Off Sci Management & Operat, Office Global Res, Rockville, MD USA.
[Ortiz-Osorno, Alberto A.] Henry M Jackson Fdn, Div Aids, Clin Res Implementat Subject Matter Expert, Rockville, MD USA.
[Ortiz-Osorno, Alberto A.; Fitzgibbon, Joseph] NIAID, Therapeut Res Program, Div Aids, US Dept Hlth & Human Serv,NIH, Rockville, MD 20892 USA.
[Gnanashanmugam, Devasena; Kim, Peter] Div Aids, Prevent Sci Program, Adolescent & Pediat Res Branch, Geneva, Switzerland.
[Gilpin, Christopher] WHO, CH-1211 Geneva, Switzerland.
[Tucker, Timothy] Advisory & Dev Consulting, Strateg Evaluat, Cape Town, South Africa.
[Peel, Sheila] Walter Reed Army Inst Res, US Mil HIV Res Program, Diagnost & Lab Monitoring, Silver Spring, MD USA.
[Peter, Trevor] Clinton Hlth Access Initiat, Diagnost, Gaborone, Botswana.
[Smith, Steven] US Dept Hlth & Human Serv, Off Global Affairs, Pretoria, South Africa.
RP Ortiz-Osorno, AA (reprint author), NIAID, Therapeut Res Program, Henry M Jackson Fdn, Div Aids,HHS,NIH, 5601 Fishers Lane,Off 9B27, Rockville, MD 20892 USA.
EM bortiz@niaid.nih.gov
FU NIAID, NIH [HHSN272200800014C]
FX This work was supported, in part, by the NIAID, NIH (contract number
HHSN272200800014C).
NR 46
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U1 2
U2 5
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1058-4838
EI 1537-6591
J9 CLIN INFECT DIS
JI Clin. Infect. Dis.
PD OCT 15
PY 2015
VL 61
SU 3
BP S119
EP S125
DI 10.1093/cid/civ552
PG 7
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA CT6WG
UT WOS:000362952900003
PM 26409272
ER
PT J
AU Lu, XCM
Shear, DA
Graham, PB
Bridson, GW
Uttamsingh, V
Chen, ZY
Leung, LY
Tortella, FC
AF Lu, Xi-Chun May
Shear, Deborah A.
Graham, Philip B.
Bridson, Gary W.
Uttamsingh, Vinita
Chen, Zhiyong
Leung, Lai Yee
Tortella, Frank C.
TI Dual Therapeutic Effects of C-10068, a Dextromethorphan Derivative,
Against Post-Traumatic Nonconvulsive Seizures and Neuroinflammation in a
Rat Model of Penetrating Ballistic-Like Brain Injury
SO JOURNAL OF NEUROTRAUMA
LA English
DT Article
DE C-10068; dextromethorphan; EEG; neuroinflammation; nonconvulsive
seizures; penetrating brain injury
ID METHYL-D-ASPARTATE; KAINATE-INDUCED SEIZURES; RECEPTOR LIGANDS; FOCAL
ISCHEMIA; NEURONAL DAMAGE; ION CHANNELS; DEXTRORPHAN; EPILEPSY; SIGMA;
PHENYTOIN
AB Post-traumatic seizures can exacerbate injurious outcomes of severe brain trauma, yet effective treatments are limited owing to the complexity of the pathology underlying the concomitant occurrence of both events. In this study, we tested C-10068, a novel deuterium-containing analog of (+)-N-methyl-3-ethoxymorphinan, in a rat model of penetrating ballistic-like brain injury (PBBI) and evaluated the effects of C-10068 on PBBI-induced nonconvulsive seizures (NCS), acute neuroinflammation, and neurofunctional outcomes. NCS were detected by electroencephalographic monitoring. Neuroinflammation was evaluated by immunohistochemical markers, for example, glial fibrillary acidic protein and major histocompatibility complex class I, for activation of astrocytes and microglia, respectively. Neurofunction was tested using rotarod and Morris water maze tasks. Three infusion doses of C-10068 (1.0, 2.5, and 5.0mg/kg/hx72h) were tested in the antiseizure study. Neuroinflammation and neurofunction were evaluated in animals treated with 5.0mg/kg/hx72h C-10068. Compared to vehicle treatment, C-10068 dose dependently reduced PBBI-induced NCS incidence (40-50%), frequency (20-70%), and duration (30-82%). The most effective antiseizure dose of C-10068 (5.0mg/kg/hx72h) also significantly attenuated hippocampal astrocyte activation and perilesional microglial reactivity post-PBBI. Within C-10068-treated animals, a positive correlation was observed in reduction in NCS frequency and reduction in hippocampal astrocyte activation. Further, C-10068 treatment significantly attenuated astrocyte activation in seizure-free animals. However, C-10068 failed to improve PBBI-induced motor and cognitive functions with the dosing regimen used in this study. Overall, the results indicating that C-10068 exerts both potent antiseizure and antiinflammatory effects are promising and warrant further investigation.
C1 [Lu, Xi-Chun May; Shear, Deborah A.; Chen, Zhiyong; Leung, Lai Yee; Tortella, Frank C.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Branch Brain Trauma Neuroprotect & Neurorestorat, Silver Spring, MD 20910 USA.
[Graham, Philip B.; Bridson, Gary W.; Uttamsingh, Vinita] Concert Pharmaceut Inc, Lexington, MA USA.
RP Lu, XCM (reprint author), Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Branch Brain Trauma Neuroprotect & Neurorestorat, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM may.lu@us.army.mil
FU U.S. Army Medical Research and Material Command; Combat Casualty Care
Research Program; Concert Pharmaceuticals Inc.
FX This work was supported by funding provided by the U.S. Army Medical
Research and Material Command, Combat Casualty Care Research Program and
Concert Pharmaceuticals Inc.
NR 59
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U1 0
U2 4
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0897-7151
EI 1557-9042
J9 J NEUROTRAUM
JI J. Neurotrauma
PD OCT 15
PY 2015
VL 32
IS 20
BP 1621
EP 1632
DI 10.1089/neu.2014.3766
PG 12
WC Critical Care Medicine; Clinical Neurology; Neurosciences
SC General & Internal Medicine; Neurosciences & Neurology
GA CS6VH
UT WOS:000362220500010
PM 25794265
ER
PT J
AU Rodriguez, RI
Jordon, JB
Allison, PG
Rushing, T
Garcia, L
AF Rodriguez, R. I.
Jordon, J. B.
Allison, P. G.
Rushing, T.
Garcia, L.
TI Microstructure and mechanical properties of dissimilar friction stir
welding of 6061-to-7050 aluminum alloys
SO MATERIALS & DESIGN
LA English
DT Article
DE Friction; Welding; Aluminum; Dissimilar; Microstructure; Fracture;
Micro-hardness; Joining
ID TOOL ROTATIONAL SPEED; PIN PROFILE; WELDED AA5083-H111; PROCESS
PARAMETERS; 6061-T6 ALUMINUM; TENSILE-STRENGTH; AL-ALLOYS; FATIGUE;
SHEETS; AA6061
AB In this work, the microstructure and mechanical properties of friction stir welded dissimilar butt joints of 6061-to-7050 aluminum alloys were evaluated. Microstructure analysis of the cross-section of the joints revealed distinct lamellar bands and various degrees of intermixing that were correlated with tool rotational speed. Due to the distinct mechanical properties of the two alloys, microhardness measurements showed a consistent asymmetric hardness distribution profile across the weld nugget, regardless of tool rotational speed. Under monotonic tensile loading, an increase in the joint strength was observed with the increase in the tool rotational speed. Regarding fracture, the joints consistently failed on the 6061 aluminum alloy side. Furthermore, two modes of failure were observed, one through the stir zone and the other through the heat-affected zone. Inspection of the fracture surfaces suggested that inadequate material intermixing produced at low tool rotational speeds was the cause for the low mechanical strength and failure through the stir zone. On the other hand, the failure observed through the heat-affected zone at high rotational speeds was produced due to the material softening as confirmed by the microhardness measurements. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Rodriguez, R. I.; Jordon, J. B.; Allison, P. G.] Univ Alabama, Dept Mech Engn, Tuscaloosa, AL 35487 USA.
[Rushing, T.; Garcia, L.] Army Corp Engineers, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA.
RP Jordon, JB (reprint author), Univ Alabama, Dept Mech Engn, Tuscaloosa, AL 35487 USA.
EM bjordon@eng.ua.edu
FU University of Alabama; GAANN Fellowship Program; Battelle Memorial
Institute [W911NF-11-D-0001]
FX The authors would like to acknowledge Mr. Robert McCullough, Dr. Mark
Barkey, and Mr. Jeb Tingle for the their helpful discussions. In
addition, the authors would like to thank Mr. Cody Rickard for his help
in preparing the samples for mechanical testing and metallurgical
analysis. The authors would also like to thank The Edison Welding
Instituted (EWI) for fabricating the FSW joints. This work was performed
under the auspices of the U.S. Army Research Office Scientific Services
Program administered by Battelle Memorial Institute, Contract No.
W911NF-11-D-0001. Permission to publish was granted by Director,
Geotechnical and Structures Laboratory. Additionally, this work utilized
resources owned and maintained by the Central Analytical Facility, which
is supported by The University of Alabama. Lastly, the authors would
like to acknowledge the GAANN Fellowship Program for support of this
project.
NR 37
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U1 7
U2 53
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0264-1275
EI 1873-4197
J9 MATER DESIGN
JI Mater. Des.
PD OCT 15
PY 2015
VL 83
BP 60
EP 65
DI 10.1016/j.matdes.2015.05.074
PG 6
WC Materials Science, Multidisciplinary
SC Materials Science
GA CO7HA
UT WOS:000359329000008
ER
PT J
AU Ngwuta, JO
Chen, M
Modjarrad, K
Joyce, MG
Kanekiyo, M
Kumar, A
Yassine, HM
Moin, SM
Killikelly, AM
Chuang, GY
Druz, A
Georgiev, IS
Rundlet, EJ
Sastry, M
Stewart-Jones, GBE
Yang, YP
Zhang, BS
Nason, MC
Capella, C
Peeples, ME
Ledgerwood, JE
McLellan, JS
Kwong, PD
Graham, BS
AF Ngwuta, Joan O.
Chen, Man
Modjarrad, Kayvon
Joyce, M. Gordon
Kanekiyo, Masaru
Kumar, Azad
Yassine, Hadi M.
Moin, Syed M.
Killikelly, April M.
Chuang, Gwo-Yu
Druz, Aliaksandr
Georgiev, Ivelin S.
Rundlet, Emily J.
Sastry, Mallika
Stewart-Jones, Guillaume B. E.
Yang, Yongping
Zhang, Baoshan
Nason, Martha C.
Capella, Cristina
Peeples, Mark E.
Ledgerwood, Julie E.
McLellan, Jason S.
Kwong, Peter D.
Graham, Barney S.
TI Prefusion F-specific antibodies determine the magnitude of RSV
neutralizing activity in human sera
SO SCIENCE TRANSLATIONAL MEDICINE
LA English
DT Article
ID RESPIRATORY SYNCYTIAL VIRUS; FUSION GLYCOPROTEIN; MONOCLONAL-ANTIBODIES;
CILIATED CELLS; INFECTION; PROTEIN; MOTAVIZUMAB; EPITOPES; VACCINE;
DESIGN
AB Respiratory syncytial virus (RSV) is estimated to claim more lives among infants <1 year old than any other single pathogen, except malaria, and poses a substantial global health burden. Viral entry is mediated by a type I fusion glycoprotein (F) that transitions from a metastable prefusion (pre-F) to a stable postfusion (post-F) trimer. A highly neutralization-sensitive epitope, antigenic site empty set, is found only on pre-F. We determined what fraction of neutralizing (NT) activity in human sera is dependent on antibodies specific for antigenic site empty set or other antigenic sites on F in healthy subjects from ages 7 to 93 years. Adsorption of individual sera with stabilized pre-F protein removed >90% of NT activity and depleted binding antibodies to both F conformations. In contrast, adsorption with post-F removed similar to 30% of NT activity, and binding antibodies to pre-F were retained. These findings were consistent across all age groups. Protein competition neutralization assays with pre-F mutants in which sites empty set or II were altered to knock out binding of antibodies to the corresponding sites showed that these sites accounted for similar to 35 and <10% of NT activity, respectively. Binding competition assays with monoclonal antibodies (mAbs) indicated that the amount of site empty set-specific antibodies correlated with NT activity, whereas the magnitude of binding competed by site II mAbs did not correlate with neutralization. Our results indicate that RSV NT activity in human sera is primarily derived from pre-F-specific antibodies, and therefore, inducing or boosting NT activity by vaccination will be facilitated by using pre-F antigens that preserve site empty set.
C1 [Ngwuta, Joan O.; Chen, Man; Modjarrad, Kayvon; Joyce, M. Gordon; Kanekiyo, Masaru; Kumar, Azad; Yassine, Hadi M.; Moin, Syed M.; Killikelly, April M.; Chuang, Gwo-Yu; Druz, Aliaksandr; Georgiev, Ivelin S.; Rundlet, Emily J.; Sastry, Mallika; Stewart-Jones, Guillaume B. E.; Yang, Yongping; Zhang, Baoshan; Nason, Martha C.; Ledgerwood, Julie E.; McLellan, Jason S.; Kwong, Peter D.; Graham, Barney S.] NIAID, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA.
[Modjarrad, Kayvon] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA.
[Capella, Cristina; Peeples, Mark E.] Ohio State Univ, Coll Med, Res Inst, Nationwide Childrens Hosp, Columbus, OH 43205 USA.
[Capella, Cristina; Peeples, Mark E.] Ohio State Univ, Coll Med, Dept Pediat, Columbus, OH 43205 USA.
[McLellan, Jason S.] Geisel Sch Med Dartmouth, Dept Biochem, Hanover, NH 03755 USA.
RP Graham, BS (reprint author), NIAID, Vaccine Res Ctr, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA.
EM bgraham@nih.gov
FU American Recovery and Reinvestment Act by the NIH [HHSN2722010000491]
FX Funding: Funding for the VRC 700 trial was provided by the American
Recovery and Reinvestment Act of 2009 (Recovery Act) through contract
#HHSN2722010000491 awarded to the EMMES Corporation by the NIH.
NR 27
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Z9 30
U1 13
U2 15
PU AMER ASSOC ADVANCEMENT SCIENCE
PI WASHINGTON
PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA
SN 1946-6234
EI 1946-6242
J9 SCI TRANSL MED
JI Sci. Transl. Med.
PD OCT 14
PY 2015
VL 7
IS 309
AR 309ra162
DI 10.1126/scitranslmed.aac4241
PG 9
WC Cell Biology; Medicine, Research & Experimental
SC Cell Biology; Research & Experimental Medicine
GA CW8FO
UT WOS:000365235100004
PM 26468324
ER
PT J
AU Moore, ME
Berejikian, BA
Goetz, FA
Berger, AG
Hodgson, SS
Connor, EJ
Quinn, TP
AF Moore, Megan E.
Berejikian, Barry A.
Goetz, Frederick A.
Berger, Andrew G.
Hodgson, Sayre S.
Connor, Edward J.
Quinn, Thomas P.
TI Multi-population analysis of Puget Sound steelhead survival and
migration behavior
SO MARINE ECOLOGY PROGRESS SERIES
LA English
DT Article
DE Steelhead; Survival; Smolts; Migration; Telemetry
ID TROUT ONCORHYNCHUS-MYKISS; SIZE-SELECTIVE MORTALITY; ATLANTIC SALMON
POSTSMOLTS; COLUMBIA RIVER ESTUARY; MARINE SURVIVAL; PACIFIC SALMON;
COHO SALMON; JUVENILE SALMONIDS; BRITISH-COLUMBIA; CHINOOK SALMON
AB Until recently, research on mortality of anadromous fishes in the marine environment was largely limited to estimates of total mortality and association with group characteristics or the environment. Advances in sonic transmitter technology now allow estimates of survival in discrete marine habitats, yielding important information on species of conservation concern. Previous telemetry studies of steelhead Oncorhynchus mykiss smolts in Puget Sound, Washington, USA indicated that approx. 80% of fish entering marine waters did not survive to the Pacific Ocean. The present study re-examined data from previous research and incorporated data from additional Puget Sound populations (n = 7 wild and 6 hatchery populations) tagged during the same period (2006-2009) for a comprehensive analysis of steelhead early marine survival. We used mark-recapture models to examine the effects of several factors on smolt survival and to identify areas of Puget Sound where mortality rates were highest. Wild smolts had higher survival probabilities in general than hatchery smolts, with exceptions, and wild smolts released in early April and late May had a higher probability of survival than those released in early and mid-May. Steelhead smolts suffered greater instantaneous mortality rates in the central region of Puget Sound and from the north end of Hood Canal through Admiralty Inlet than in other monitored migration segments. Early marine survival rates were low (16.0 and 11.4% for wild and hatchery populations, respectively) and consistent among wild populations, indicating a common rather than watershed-specific mortality source. With segment-specific survival information we can begin to identify locations associated with high rates of mortality, and identify the mechanisms responsible.
C1 [Moore, Megan E.; Berejikian, Barry A.] Natl Ocean & Atmospher Adm Fisheries, Environm & Fisheries Sci, NW Fisheries Sci Ctr, Natl Marine Fisheries Serv, Manchester, WA 98353 USA.
[Goetz, Frederick A.] US Army Corps Engineers, Seattle, WA 98134 USA.
[Berger, Andrew G.] Puyallup Tribe Indians, Puyallup Tribe Fisheries Dept, Tacoma, WA 98404 USA.
[Hodgson, Sayre S.] Nisqually Indian Tribe, Dept Nat Resources, Olympia, WA 98513 USA.
[Connor, Edward J.] City Seattle, Seattle City Light, Seattle, WA 98104 USA.
[Quinn, Thomas P.] Univ Washington, Sch Aquat & Fishery Sci, Seattle, WA 98195 USA.
RP Moore, ME (reprint author), Natl Ocean & Atmospher Adm Fisheries, Environm & Fisheries Sci, NW Fisheries Sci Ctr, Natl Marine Fisheries Serv, POB 130, Manchester, WA 98353 USA.
EM megan.moore@noaa.gov
FU Steelhead Trout Club; Wild Steelhead Coalition; Nisqually Tribe;
Puyallup Tribe; Squaxin Tribe; H. Mason Keeler Endowment; Washington
Department of Fish and Wildlife; King County Department of Natural
Resources; Seattle City Light; US Army Corps of Engineers; NOAA
Fisheries; Pacific Ocean Shelf Tracking; Washington State
FX This is Publication Number 2 from the Salish Sea Marine Survival
Project: an international, collaborative research effort designed to
determine the primary factors affecting the survival of juvenile
chinook, coho and steelhead survival in the combined marine waters of
Puget Sound and Strait of Georgia (marinesurvivalproject.com). Funding
was provided by Washington State with equal in-kind contributions by
those participating in the research. Additional funding was provided by
the Steelhead Trout Club, Wild Steelhead Coalition, Nisqually Tribe,
Puyallup Tribe, Squaxin Tribe, H. Mason Keeler Endowment to the
University of Washington, Washington Department of Fish and Wildlife,
King County Department of Natural Resources, Seattle City Light, US Army
Corps of Engineers, NOAA Fisheries, Pacific Ocean Shelf Tracking. The
study could not have been successful without the help of several
individuals, to whom we are grateful, especially Skip Tezak, Joy Lee
Waltermire, Rick Endicott, Teresa Sjostrom, Sean Hildebrandt, Mat
Gillam, Eric Jeanes, Catherine Morello, Bob Leland, Kelly Kiyohara, Pat
Michael, Brody Antipa, Pete Topping, Deborah Feldman, Kelly Andrews,
John Blaine, Jim Deveraux, Correigh Greene, Shawn Larson, Jeff
Christiansen, John Rupp, Chuck Ebel, Hal Boynton, Nate Mantua, John
Kelly, Ed Conroy, Jose Reyes-Tomassini, Jennifer Scheurell, Chris Ewing,
Dawn Pucci, Kurt Dobszinsky, Paul Winchell, David Welch, Debbie Goetz,
Jose Gimenez, Aswea Porter, Emiliano Perez, Craig Smith, Tim Willson,
Florian Leischner, Christopher Ellings, and Scott Steltzner. We also
thank Mike Melnychuk and Jeff Laake for crucial support of the
mark-recapture modeling process.
NR 59
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U1 3
U2 21
PU INTER-RESEARCH
PI OLDENDORF LUHE
PA NORDBUNTE 23, D-21385 OLDENDORF LUHE, GERMANY
SN 0171-8630
EI 1616-1599
J9 MAR ECOL PROG SER
JI Mar. Ecol.-Prog. Ser.
PD OCT 14
PY 2015
VL 537
BP 217
EP 232
DI 10.3354/meps11460
PG 16
WC Ecology; Marine & Freshwater Biology; Oceanography
SC Environmental Sciences & Ecology; Marine & Freshwater Biology;
Oceanography
GA CU0BR
UT WOS:000363180900017
ER
PT J
AU Timmerwilke, J
Petrie, JR
Wieland, KA
Mencia, R
Liou, SH
Cress, CD
Newburgh, GA
Edelstein, AS
AF Timmerwilke, John
Petrie, J. R.
Wieland, K. A.
Mencia, Raymond
Liou, Sy-Hwang
Cress, C. D.
Newburgh, G. A.
Edelstein, A. S.
TI Using magnetic permeability bits to store information
SO JOURNAL OF PHYSICS D-APPLIED PHYSICS
LA English
DT Article
DE memory; permeability; phase; change
ID BULK METALLIC GLASSES; MEMORY
AB Steps are described in the development of a new magnetic memory technology, based on states with different magnetic permeability, with the capability to reliably store large amounts of information in a high-density form for decades. The advantages of using the permeability to store information include an insensitivity to accidental exposure to magnetic fields or temperature changes, both of which are known to corrupt memory approaches that rely on remanent magnetization. The high permeability media investigated consists of either films of Metglas 2826 MB (Fe40Ni38Mo4B18) or bilayers of permalloy (Ni78Fe22)/Cu. Regions of films of the high permeability media were converted thermally to low permeability regions by laser or ohmic heating. The permeability of the bits was read by detecting changes of an external 32 Oe probe field using a magnetic tunnel junction 10 mu m away from the media. Metglas bits were written with 100 mu s laser pulses and arrays of 300 nm diameter bits were read. The high and low permeability bits written using bilayers of permalloy/Cu are not affected by 10 Mrad(Si) of gamma radiation from a Co-60 source. An economical route for writing and reading bits as small at 20 nm using a variation of heat assisted magnetic recording is discussed.
C1 [Timmerwilke, John; Petrie, J. R.; Mencia, Raymond; Newburgh, G. A.; Edelstein, A. S.] US Army Res Lab, Adelphi, MD 20783 USA.
[Wieland, K. A.] Corning Inc, Painted Post, NY 14870 USA.
[Liou, Sy-Hwang] Univ Nebraska, Dept Phys, Lincoln, NE 68588 USA.
[Cress, C. D.] Naval Res Lab, Washington, DC 20375 USA.
RP Timmerwilke, J (reprint author), US Army Res Lab, Adelphi, MD 20783 USA.
EM aedelstein@cox.net
OI Cress, Cory/0000-0001-7563-6693
NR 19
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Z9 1
U1 2
U2 7
PU IOP PUBLISHING LTD
PI BRISTOL
PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
SN 0022-3727
EI 1361-6463
J9 J PHYS D APPL PHYS
JI J. Phys. D-Appl. Phys.
PD OCT 14
PY 2015
VL 48
IS 40
AR 405002
DI 10.1088/0022-3727/48/40/405002
PG 6
WC Physics, Applied
SC Physics
GA CS3WQ
UT WOS:000362006400003
ER
PT J
AU Zhou, L
Mehta, A
Giri, A
Cho, K
Sohn, Y
AF Zhou, Le
Mehta, Abhishek
Giri, Anit
Cho, Kyu
Sohn, Yongho
TI Martensitic transformation and mechanical properties of Ni49+xMn36-xIn15
(x=0, 0.5, 1.0, 1.5 and 2.0) alloys
SO MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES
MICROSTRUCTURE AND PROCESSING
LA English
DT Article
DE Ni-Mn-In alloy; Transmission electron microscopy; Nanoindentation;
Martensitic transformation; 7M crystal structure
ID SHAPE-MEMORY ALLOYS; MN-GA ALLOYS; FIELD-INDUCED STRAINS;
PHASE-TRANSFORMATION; ELASTIC-MODULUS; NI; NI2MNGA; INDENTATION;
TRANSITIONS; HARDNESS
AB Five polycrystalline Ni(49+x)Mn(36-x)ln(15) (x=0, 0.5, 1.0, 1.5 and 2) alloys were prepared by triple arc-melting and examined to understand their martensitic transformation and mechanical properties. Martensitic transformation temperatures were determined by differential scanning calorimetry (DSC) and observed to increase with increasing Ni content. Powder X-ray diffraction (XRD) and transmission electron microscopy (TEM) showed that Ni49Mn36In15 is austenitic at room temperature while modulated 7M martensitic structure was observed in other alloys. Different twinning relationships between martensitic variants were revealed by TEM. Reduced elastic modulus and hardness were measured by nanoindentation. For the martensites, the reduced elastic modulus increased as the e/a increases, while hardness did not vary. The austenitic phase exhibited a lower reduced elastic modulus and hardness. A larger scatter in the reduced elastic modulus and hardness was observed for the martensitic phase in conjunction with variants of different orientation. The martensitic transformation behavior and nanoindentation results were also compared with Ni53+xMn22-xGa25 (x=0.5, 1.0, 1.8 and 2.5) alloys. For both Ni-Mn-In and Ni-Mn-Ga alloys, the martensitic transformation temperature and reduced elastic modulus increased as the e/a ratio increased. (C) 2015 Elsevier B.V. All rights reserved.
C1 [Zhou, Le; Mehta, Abhishek; Sohn, Yongho] Univ Cent Florida, Dept Mat Sci & Engn, Orlando, FL 32816 USA.
[Zhou, Le; Mehta, Abhishek; Sohn, Yongho] Univ Cent Florida, Adv Mat Proc & Anal Ctr, Orlando, FL 32816 USA.
[Giri, Anit] TKC Global, Herndon, VA 20171 USA.
[Giri, Anit; Cho, Kyu] US Army, Weap & Mat Res Directorate, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RP Sohn, Y (reprint author), Univ Cent Florida, Dept Mat Sci & Engn, Orlando, FL 32816 USA.
EM Yongho.Sohn@ucf.edu
RI Sohn, Yongho/A-8517-2010; Zhou, Le/H-9531-2016
OI Sohn, Yongho/0000-0003-3723-4743; Zhou, Le/0000-0001-8327-6667
FU U.S. Army Research Laboratory [W911NF-11-2-0020]
FX This research was sponsored by the U.S. Army Research Laboratory through
cooperative agreement #W911NF-11-2-0020 between University of Central
Florida and the U.S. Army Research Laboratory. The views, opinions and
conclusions made in this document are those of the authors and should
not be interpreted as representing the official policies, either
expressed or implied, of the U.S. Army Research Laboratory or the U.S.
Government. The U.S. Government is authorized to reproduce and
distribute reprints for Government purposes notwithstanding any
copyright notation herein. The authors would also like to thank Mr.
Timothy Delahanty at Pittsburgh Materials Technology, Pittsburgh,
Pennsylvania, USA, for preparation of the alloys.
NR 42
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Z9 1
U1 10
U2 35
PU ELSEVIER SCIENCE SA
PI LAUSANNE
PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND
SN 0921-5093
EI 1873-4936
J9 MAT SCI ENG A-STRUCT
JI Mater. Sci. Eng. A-Struct. Mater. Prop. Microstruct. Process.
PD OCT 14
PY 2015
VL 646
BP 57
EP 65
DI 10.1016/j.msea.2015.08.034
PG 9
WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary;
Metallurgy & Metallurgical Engineering
SC Science & Technology - Other Topics; Materials Science; Metallurgy &
Metallurgical Engineering
GA CS5QC
UT WOS:000362132000008
ER
PT J
AU Beck, Z
Matyas, GR
Jalah, R
Rao, M
Polonis, VR
Alving, CR
AF Beck, Zoltan
Matyas, Gary R.
Jalah, Rashmi
Rao, Mangala
Polonis, Victoria R.
Alving, Carl R.
TI Differential immune responses to HIV-1 envelope protein induced by
liposomal adjuvant formulations containing monophosphoryl lipid A with
or without QS21
SO VACCINE
LA English
DT Article
DE Adjuvants; Liposomes; Monophosphoryl lipid A; QS21; HIV CN54 gp140
envelope protein; AS01B
ID VACCINE ADJUVANTS; MONOCLONAL-ANTIBODIES; IMMUNIZATION; ANTIGENS;
IMMUNOGENICITY; GLYCOPROTEIN; INDUCTION; MEMBRANES; SELECTION; DELIVERY
AB Liposomes have shown promise as constituents of adjuvant formulations in vaccines to parasitic and viral diseases. A particular type of liposomal construct, referred to as Army Liposome Formulation (ALF), containing neutral and anionic saturated phospholipids, cholesterol, and monophosphoryl lipid A (MPLA), has been used as an adjuvant for many years. Here we investigated the effects of physical and chemical changes of ALF liposomes on adjuvanted immune responses to CN54 gp140, a recombinant HIV-1 envelope protein. While holding the total amounts of liposomal MPLA and the gp140 antigen constant, different liposome sizes and liposomal MPLA:phospholipid molar ratios, and the effect of adding QS21 to the liposomes were compared for inducing immune responses to the gp140. For liposomes lacking QS21, higher titers of IgG binding antibodies to gp140 were induced by small unilamellar vesicle (SUV) rather than by large multilamellar vesicle (MLV) liposomes, and the highest titers were obtained with Shy having the MPLA:phospholipid ratio of 1:5.6. ALF plus QS21 (ALFQ) liposomes induced the same maximal binding antibody titers regardless of the MPLA:phospholipid ratio. ALF MLV liposomes induced mainly IgG1 and very low IgG2a antibodies, while ALF Shy liposomes induced IgG1 >= IgG2a > IgG2b antibodies. Liposomes containing QS21 induced IgG1 > IgG2a > IgG2b > IgG3 antibodies. ELISPOT analysis of splenocytes from immunized mice revealed that ALF liposomes induced low levels of IFN-gamma, but ALFQ induced high levels. ALF and ALFQ liposomes each induced approximately equivalent high levels of IL-4. Based on antibody subtypes and cytokine secretion, we conclude that ALF liposomes predominantly stimulate Th2, while ALFQ strongly induces both Th1 and Th2 immunity. When CN54gp140 was adjuvanted with either ALF or ALFQ liposomes, antibodies were induced that neutralized two HIV-1 tier 1 clade C strain pseudoviruses. Published by Elsevier Ltd.
C1 [Beck, Zoltan; Jalah, Rashmi] Henry M Jackson Fdn Adv Mil Med, US Mil HIV Res Program, Bethesda, MD 20817 USA.
[Beck, Zoltan; Matyas, Gary R.; Jalah, Rashmi; Rao, Mangala; Alving, Carl R.] Walter Reed Army Inst Res, US Mil HIV Res Program, Lab Adjuvant & Antigen Res, Silver Spring, MD 20910 USA.
[Polonis, Victoria R.] Walter Reed Army Inst Res, US Mil HIV Res Program, Lab Vaccine Immunol, Silver Spring, MD 20910 USA.
RP Alving, CR (reprint author), Walter Reed Army Inst Res, US Mil HIV Res Program, Lab Adjuvant & Antigen Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM calving@hivresearch.org
OI Matyas, Gary/0000-0002-2074-2373
FU Henry M. Jackson Foundation for the Advancement of Military Medicine
[W81XWH-07-2-067]; U.S. Army Medical Research and Materiel Command
(MRMC) [W81XWH-07-2-067]
FX This work was supported through a Cooperative Agreement Award (no.
W81XWH-07-2-067) between the Henry M. Jackson Foundation for the
Advancement of Military Medicine and the U.S. Army Medical Research and
Materiel Command (MRMC). The authors thank Dr. Kristina Peachman for
assistance with light microscopy; Mr. Christopher Spiridon for technical
assistance, Mr. Sebastian Molnar for neutralization experiments, and Mr
Marcus Gallon for the veterinarian work. Research was conducted in
compliance with the Animal Welfare Act and other federal statutes and
regulations relating to animals and experiments involving animals and
adhered to principles stated in the Guide for the Care and Use of
Laboratory Animals, NRC Publication, 1996 edition. The views expressed
in this article are those of the authors and do not necessarily reflect
the official policy of the Department of the Army, Department of
Defense, or the U.S. Government.
NR 50
TC 7
Z9 7
U1 0
U2 3
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0264-410X
EI 1873-2518
J9 VACCINE
JI Vaccine
PD OCT 13
PY 2015
VL 33
IS 42
BP 5578
EP 5587
DI 10.1016/j.vaccine.2015.09.001
PG 10
WC Immunology; Medicine, Research & Experimental
SC Immunology; Research & Experimental Medicine
GA CV4WZ
UT WOS:000364268500017
PM 26372857
ER
PT J
AU Athrey, G
Lance, RF
Leberg, PL
AF Athrey, Giridhar
Lance, Richard F.
Leberg, Paul L.
TI Using Genealogical Mapping and Genetic Neighborhood Sizes to Quantify
Dispersal Distances in the Neotropical Passerine, the Black-Capped Vireo
SO PLOS ONE
LA English
DT Article
ID EFFECTIVE POPULATION-SIZE; PARENTAGE ANALYSIS; HABITAT FRAGMENTATION;
COMPUTER-PROGRAM; LINKAGE DISEQUILIBRIUM; RESTRICTED DISPERSAL; ACADIAN
FLYCATCHERS; NATURAL-POPULATIONS; BREEDING DISPERSAL; GENOTYPING ERRORS
AB Dispersal is a key demographic process, ultimately responsible for genetic connectivity among populations. Despite its importance, quantifying dispersal within and between populations has proven difficult for many taxa. Even in passerines, which are among the most intensely studied, individual movement and its relation to gene flow remains poorly understood. In this study we used two parallel genetic approaches to quantify natal dispersal distances in a Neotropical migratory passerine, the black-capped vireo. First, we employed a strategy of sampling evenly across the landscape coupled with parentage assignment to map the genealogical relationships of individuals across the landscape, and estimate dispersal distances; next, we calculated Wright's neighborhood size to estimate gene dispersal distances. We found that a high percentage of captured individuals were assigned at short distances within the natal population, and males were assigned to the natal population more often than females, confirming sex-biased dispersal. Parentage-based dispersal estimates averaged 2400m, whereas gene dispersal estimates indicated dispersal distances ranging from 1600-4200 m. Our study was successful in quantifying natal dispersal distances, linking individual movement to gene dispersal distances, while also providing a detailed look into the dispersal biology of Neotropical passerines. The high-resolution information was obtained with much reduced effort (sampling only 20% of breeding population) compared to mark-resight approaches, demonstrating the potential applicability of parentage-based approaches for quantifying dispersal in other vagile passerine species.
C1 [Athrey, Giridhar] Texas A&M Univ, Dept Poultry Sci, College Stn, TX 77843 USA.
[Athrey, Giridhar] Texas A&M Univ, Fac Ecol & Evolutionary Biol, College Stn, TX USA.
[Athrey, Giridhar; Leberg, Paul L.] Univ Louisiana Lafayette, Dept Biol, Lafayette, LA 70504 USA.
[Lance, Richard F.] USACE, Environm Lab, Vicksburg, MS USA.
RP Athrey, G (reprint author), Texas A&M Univ, Dept Poultry Sci, 2472 TAMU, College Stn, TX 77843 USA.
EM giri.athrey@tamu.edu
FU US Department of Defense under Section 6.1 Basic research program; U.S.
Army 6.2 Threatened and Endangered Species program; National Geographic
Society Committee for Research and Exploration grant
FX This study was partly funded by US Department of Defense under Section
6.1 Basic research program and U.S. Army 6.2 Threatened and Endangered
Species program to RFL and PLL
(http://www.acq.osd.mil/rd/basic_research/program_info/funding.html).
Part of this study was also funded by a National Geographic Society
Committee for Research and Exploration grant to GA. The funders had no
role in study design, data collection, analysis, decision to publish or
preparation of manuscript.
NR 71
TC 0
Z9 0
U1 6
U2 10
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD OCT 13
PY 2015
VL 10
IS 10
AR e0140115
DI 10.1371/journal.pone.0140115
PG 20
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CT6ZJ
UT WOS:000362962300055
PM 26461257
ER
PT J
AU Yehuda, R
Hoge, CW
McFarlane, AC
Vermetten, E
Lanius, R
Nievergelt, CM
Hobfoll, SE
Koenen, KC
Neylan, TC
Hyman, SE
AF Yehuda, Rachel
Hoge, Charles W.
McFarlane, Alexander C.
Vermetten, Eric
Lanius, Rutha.
Nievergelt, Caroline M.
Hobfoll, Stevan E.
Koenen, Karestan C.
Neylan, Thomas C.
Hyman, Steven E.
TI Post-traumatic stress disorder
SO NATURE REVIEWS DISEASE PRIMERS
LA English
DT Article
ID COGNITIVE-BEHAVIORAL THERAPY; GENOME-WIDE ASSOCIATION; RANDOMIZED
CONTROLLED-TRIAL; PROLONGED EXPOSURE THERAPY; NATIONAL COMORBIDITY
SURVEY; SMALLER HIPPOCAMPAL VOLUME; MENTAL-HEALTH PROBLEMS; SCALE BRAIN
NETWORKS; CEREBRAL-BLOOD-FLOW; PTSD SYMPTOMS
AB Post-traumatic stress disorder (PTSD) occurs in 5-10% of the population and is twice as common in women as in men. Although trauma exposure is the precipitating event for PTSD to develop, biological and psychosocial risk factors are increasingly viewed as predictors of symptom onset, severity and chronicity. PTSD affects multiple biological systems, such as brain circuitry and neurochemistry, and cellular, immune, endocrine and metabolic function. Treatment approaches involve a combination of medications and psychotherapy, with psychotherapy overall showing greatest efficacy. Studies of PTSD pathophysiology initially focused on the psychophysiology and neurobiology of stress responses, and the acquisition and the extinction of fear memories. However, increasing emphasis is being placed on identifying factors that explain individual differences in responses to trauma and promotion of resilience, such as genetic and social factors, brain developmental processes, cumulative biological and psychological effects of early childhood and other stressful lifetime events. The field of PTSD is currently challenged by fluctuations in diagnostic criteria, which have implications for epidemiological, biological, genetic and treatment studies. However, the advent of new biological methodologies offers the possibility of large-scale approaches to heterogeneous and genetically complex brain disorders, and provides optimism that individualized approaches to diagnosis and treatment will be discovered.
C1 [Yehuda, Rachel] James J Peters Vet Affairs Med Ctr, 130 West Kingsbridge Rd, New York, NY 10468 USA.
[Yehuda, Rachel] Icahn Sch Med Mt Sinai, New York, NY USA.
[Hoge, Charles W.] Walter Reed Army Inst Res, Silver Spring, MD USA.
[McFarlane, Alexander C.] Univ Adelaide, Ctr Traumat Stress Studies, Adelaide, SA, Australia.
[Vermetten, Eric] Minist Def, Military Mental Hlth Res Ctr, Utrecht, Netherlands.
[Vermetten, Eric] Leiden Univ, Med Ctr, Dept Psychiat, Leiden, Netherlands.
[Vermetten, Eric] Arq Psychotrauma Expert Grp, Diemen, Netherlands.
[Lanius, Rutha.] Western Univ Canada, Dept Psychiat, London, ON, Canada.
[Nievergelt, Caroline M.] Univ Calif San Diego, Sch Med, Dept Psychiat, La Jolla, CA USA.
[Nievergelt, Caroline M.] VA San Diego Healthcare Syst, VA Ctr Excellence Stress & Mental Hlth CESAMH, La Jolla, CA USA.
[Hobfoll, Stevan E.] Rush Univ, Med Ctr, Dept Behav Sci, Chicago, IL USA.
[Koenen, Karestan C.] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.
[Koenen, Karestan C.] Massachusetts Gen Hosp, Dept Psychiat, Boston, MA USA.
[Koenen, Karestan C.; Hyman, Steven E.] Broad Inst MIT & Harvard, Stanley Ctr, Cambridge, MA USA.
[Neylan, Thomas C.] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA USA.
[Neylan, Thomas C.] San Francisco VA Med Ctr, Mental Hlth Serv, San Francisco, CA USA.
[Hyman, Steven E.] Harvard Univ, Dept Stem Cell & Regenerat Biol, Cambridge, MA USA.
RP Yehuda, R (reprint author), James J Peters Vet Affairs Med Ctr, 130 West Kingsbridge Rd, New York, NY 10468 USA.
EM rachel.yehuda@va.gov
FU US Department of Defense [DOD W81XWH-10-2-0072, DOD W81XWH-13-1-0071];
Lightfighter Trust Foundation [LFT2009-02-1]; National Health and
Medical Research Council Program [568970]; US National Institutes of
Health (NIH) [R01MH093500]; National Institute of Mental Health
[RO1MH073687]; Rush Center for Urban Health Equity [NIH-NHLBI
1P50HL105189]; NIH [MH078928, MH093612]; U.S. Army Medical Research &
Materiel Command (USAMRMC) [W81XWH-11-2-0189]; Mental Illness Research
and Education Clinical Center of the US Veterans Health Administration
FX R.Y. is supported by grants from the US Department of Defense (DOD
W81XWH-10-2-0072 and DOD W81XWH-13-1-0071) and a grant from the
Lightfighter Trust Foundation (LFT2009-02-1). A.C.M. is supported in
part by National Health and Medical Research Council Program Grant
number 568970. C.M.N. is supported in part by US National Institutes of
Health (NIH) grant R01MH093500. S.E. Hobfoll is partly supported by a
grant from the National Institute of Mental Health (RO1MH073687) and the
Rush Center for Urban Health Equity (NIH-NHLBI 1P50HL105189). K.C.K. is
supported by grants NIH MH078928 and MH093612. T.C.N. is supported in
part by a research grant that was awarded and administered by the U.S.
Army Medical Research & Materiel Command (USAMRMC; TCN:
W81XWH-11-2-0189) and the Mental Illness Research and Education Clinical
Center of the US Veterans Health Administration. The authors would like
to thank L.M. Bierer for her careful final review of the manuscript,
M.E. Bowers for assistance with the development of the graphics and
review of references, and H. Bader for administrative coordination and
integration of multiple versions of the document.
NR 254
TC 8
Z9 8
U1 15
U2 18
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2056-676X
J9 NAT REV DIS PRIMERS
JI Nat. Rev. Dis. Primers
PD OCT 8
PY 2015
VL 1
AR 15057
DI 10.1038/nrdp.2015.57
PG 22
WC Medicine, General & Internal
SC General & Internal Medicine
GA DT2WY
UT WOS:000381343700001
PM 27189040
ER
PT J
AU Li, M
Yang, X
Zhang, Y
Zhao, G
Beadsworth, J
Eifert, L
Tucker, F
Deppe, DG
AF Li, M.
Yang, X.
Zhang, Y.
Zhao, G.
Beadsworth, J.
Eifert, L.
Tucker, F.
Deppe, D. G.
TI 901 nm Lithographic vertical-cavity surface-emitting laser with stable
single-lobed beam pattern
SO ELECTRONICS LETTERS
LA English
DT Article
AB Data are presented on 901 nm lithographic vertical-cavity surface-emitting lasers (VCSELs) demonstrating high efficiency for small VCSEL sizes, and stable beam patterns. Power conversion efficiency >40% is obtained for VCSELs ranging in size from 6 to 2 mu m diameter. The 2 mu m diameter VCSELs produce output powers in excess of 6.5 mW, and produce single-lobed far-field radiation patterns over the full range of operation.
C1 [Li, M.; Yang, X.; Zhang, Y.; Deppe, D. G.] Univ Cent Florida, Coll Opt & Photon, CREOL, Orlando, FL 32816 USA.
[Zhao, G.; Beadsworth, J.; Deppe, D. G.] SdPhoton LLC, Orlando, FL 32816 USA.
[Eifert, L.; Tucker, F.] Army Res Lab, Orlando, FL 32826 USA.
RP Deppe, DG (reprint author), Univ Cent Florida, Coll Opt & Photon, CREOL, Orlando, FL 32816 USA.
EM ddeppe@creol.ucf.edu
FU ARL [W911NF-14-C-0088]; ARO [W911NF-12-1-0046]
FX sdPhotonics work has been supported by the ARL under contract no.
W911NF-14-C-0088. Work by the University of Central Florida has been
supported by ARO grant no. W911NF-12-1-0046.
NR 3
TC 0
Z9 0
U1 3
U2 8
PU INST ENGINEERING TECHNOLOGY-IET
PI HERTFORD
PA MICHAEL FARADAY HOUSE SIX HILLS WAY STEVENAGE, HERTFORD SG1 2AY, ENGLAND
SN 0013-5194
EI 1350-911X
J9 ELECTRON LETT
JI Electron. Lett.
PD OCT 8
PY 2015
VL 51
IS 21
BP 1683
EP U104
DI 10.1049/el.2015.3003
PG 2
WC Engineering, Electrical & Electronic
SC Engineering
GA CV3ZS
UT WOS:000364205800033
ER
PT J
AU Scarboro, M
Price, J
Gillich, P
AF Scarboro, Mark
Price, Jan
Gillich, Patrick
TI The Development of AIS 2015
SO TRAFFIC INJURY PREVENTION
LA English
DT Article; Proceedings Paper
CT 59th Annual Scientific Conference of the Association for the Advancement
of Automotive Medicine (AAAM)
CY OCT 04-07, 2015
CL philadelphia, PA
DE AIS; trauma; injury; coding
AB Objective: The Abbreviated Injury Scale (AIS) developed and maintained by the Association for the Advancement of Automotive Medicine (AAAM) is the gold standard for traumatic injury classification and severity scaling. The aim of this work was to document the development of AIS 2015, the next revision of the AIS, by incorporating the needs of its users and the current status of traumatic injury diagnosis and documentation.
Methods: AIS 2015 was developed utilizing a committee of international multidisciplinary experts in the field of traumatic injury. The committee consisted of physicians, nurses, engineers, researchers, certified AIS coders and AIS trainers. The committee based its decisions on participant consensus and data analysis of current trauma data, injury diagnostics, classifications and requested enhancements to the current AIS revision, AIS 2005 / Update 2008. Along with the code updates, translation tables for AIS 2015 to and from AIS 2005 / Update 2008 were developed as well as applicable Functional Capacity Index (FCI) score associations. Committee meetings and AIS 2015 development started in 2011 and AIS 2015 was completed for field testing in late 2014.
Results: AIS 2015 incorporates many significant changes to several different body region chapters. More than 140 completely new AIS codes were created for AIS 2015. Many of the new codes were generated to improve the classification of high energy military type blast and penetrating injury. Nearly 400 codes underwent definition update, severity level was updated on more than 40 codes and more than 140 AIS 2005 / Update 2008 codes were deleted for AIS 2015. The AIS clarifications done (2012 and 2013) by AAAM were also incorporated into AIS 2015. In conjunction with the code updates, many coding guidelines and rules have been enhanced. The most significant changes were in the head and spine chapters.
Conclusions: AIS 2015 is the next step in the continual evolution of traumatic injury classification and scaling. The newest revision improves brain injury coding, spinal cord impairment coding and enhances many code definitions by incorporating current and appropriate medical terminology. Clearer and expanded coding rules encourage improved interrater reliability. AIS 2015 is an improved tool for both medical coders and researchers.
C1 [Scarboro, Mark] Natl Highway Traff Safety Adm, Human Injury Res Div, Washington, DC 20590 USA.
[Price, Jan] Assoc Adv Automot Med, New York, NY USA.
[Gillich, Patrick] US Army Res Lab, Adelphi, MD USA.
RP Scarboro, M (reprint author), Natl Highway Traff Safety Adm, Human Injury Res Div, Washington, DC 20590 USA.
NR 6
TC 0
Z9 0
U1 2
U2 3
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1538-9588
EI 1538-957X
J9 TRAFFIC INJ PREV
JI Traffic Inj. Prev.
PD OCT 8
PY 2015
VL 16
SU 2
SI SI
BP S246
EP S248
PG 3
WC Public, Environmental & Occupational Health; Transportation
SC Public, Environmental & Occupational Health; Transportation
GA CS8IN
UT WOS:000362330800037
ER
PT J
AU Larson, JM
Bharath, SC
Cullen, WG
Reutt-Robey, JE
AF Larson, Jonathan M.
Bharath, Satyaveda C.
Cullen, William G.
Reutt-Robey, Janice E.
TI Scanning MWCNT-Nanopipette and Probe Microscopy: Li Patterning and
Transport Studies
SO SMALL
LA English
DT Article
ID MULTIWALLED CARBON NANOTUBES; TUNNELING MICROSCOPE; MASS-TRANSPORT;
ELECTROCHEMICAL INTERCALATION; LITHIUM INTERCALATION; SI(111)7X7
SURFACE; NECK FORMATION; ION-BEAM; DIFFUSION; METAL
AB A carbon-nanotube-enabling scanning probe technique/nanotechnology for manipulating and measuring lithium at the nano/mesoscale is introduced. Scanning Li-nanopipette and probe microscopy (SLi-NPM) is based on a conductive atomic force microscope (AFM) cantilever with an open-ended multi-walled carbon nanotube (MWCNT) affixed to its apex. SLi-NPM operation is demonstrated with a model system consisting of a Li thin film on a Si(111) substrate. By control of bias, separation distance, and contact time, attograms of Li can be controllably pipetted to or from the MWCNT tip. Patterned surface Li features are then directly probed via noncontact AFM measurements with the MWCNT tip. The subsequent decay of Li features is simulated with a mesoscale continuum model, developed here. The Li surface diffusion coefficient for a four (two) Li layer thick film is measured as D=8(+/- 1.2) x 10(-15) cm(2) s(-1) (D=1.75(+/- 0.15) x 10-(15) cm(2) s(-1)). Dual-Li pipetting/measuring with SLi-NPM enables a broad range of time-dependent Li and nanoelectrode characterization studies of fundamental importance to energy-storage research.
C1 [Larson, Jonathan M.; Cullen, William G.] Univ Maryland, Dept Phys, College Pk, MD 20742 USA.
[Bharath, Satyaveda C.; Reutt-Robey, Janice E.] Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA.
[Bharath, Satyaveda C.] US Army Res Lab, Aberdeen, MD 21005 USA.
[Cullen, William G.] NIST, Gaithersburg, MD 20899 USA.
RP Reutt-Robey, JE (reprint author), Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA.
EM rrobey@umd.edu
FU Nanostructures for Electrical Energy Storage (NEES), an Energy Frontier
Research Center - US Department of Energy, Office of Science, Basic
Energy Sciences [DESC0001160]
FX The authors acknowledge Wentao Song for performing Auger measurements,
Theodore Einstein for advice on diffusion modeling, and Michael Fuhrer
for discussion of the experimental concept. This work was supported as
part of the Nanostructures for Electrical Energy Storage (NEES), an
Energy Frontier Research Center funded by the US Department of Energy,
Office of Science, Basic Energy Sciences under Award number DESC0001160.
NR 72
TC 2
Z9 2
U1 5
U2 35
PU WILEY-V C H VERLAG GMBH
PI WEINHEIM
PA POSTFACH 101161, 69451 WEINHEIM, GERMANY
SN 1613-6810
EI 1613-6829
J9 SMALL
JI Small
PD OCT 7
PY 2015
VL 11
IS 37
BP 4946
EP 4958
DI 10.1002/smll.201500999
PG 13
WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience &
Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied;
Physics, Condensed Matter
SC Chemistry; Science & Technology - Other Topics; Materials Science;
Physics
GA CT5AR
UT WOS:000362819400018
PM 26182911
ER
PT J
AU Bromberg, L
Creasy, WR
McGarvey, DJ
Wilusz, E
Hatton, TA
AF Bromberg, Lev
Creasy, William R.
McGarvey, David J.
Wilusz, Eugene
Hatton, T. Alan
TI Nucleophilic Polymers and Gels in Hydrolytic Degradation of Chemical
Warfare Agents
SO ACS APPLIED MATERIALS & INTERFACES
LA English
DT Article
DE polyvinylamine; polyallylamine; nucleophilic polymers; chemical warfare
agents; VX; HD; hydrogels; self-decontaminating fabrics
ID NERVE AGENT; 2-CHLOROETHYL SULFIDES; SULFUR MUSTARD; NITROGEN MUSTARDS;
REACTIVITY; DECONTAMINATION; PHOSPHATE; CATALYSTS; KINETICS; ESTERS
AB Water- and solvent-soluble polymeric materials based on polyalkylamines modified with nucleophilic groups are introduced as catalysts of chemical warfare agent (CWA) hydrolysis. A comparative study conducted at constant pH and based on the criteria of the synthetic route simplicity, aqueous solubility, and rate of hydrolysis of CWA mimic, diisopropylfluorophosphate (DFP), indicated that 4-aminopyridine-substituted polyallylamine (PAAm-APy) and polyvinylamine substituted with 4-aminopyridine (PVAm-APy) were advantageous over 4-pyridinealdoxime-modified PVAm and PAAm, poly(butadiene-co-pyrrolidinopyridine), and PAAm modified with bipyridine and its complex with Cu(II). The synthesis of PVAm-APy and PAAm-APy involved generation of a betaine derivative of acrylamide and its covalent attachment onto the polyalkylamine chain followed by basic hydrolysis. Hydrogel particles of PAAm-APy and PVAm-APy cross-linked by epichlorohydrin exhibited pH-dependent swelling and ionization patterns that affected the rate constants of DFP nucleophilic hydrolysis. Deprotonation of the aminopyridine and amine groups increased the rates of the nucleophilic hydrolysis. The second-order rate of nucleophilic hydrolysis was 5.5- to 10-fold higher with the nucleophile-modified gels compared to those obtained by cross-linking of unmodified PAAm, throughout the pH range. Testing of VX and soman (GD) was conducted in 2.5-3.7 wt % PVAm-APy suspensions or gels swollen in water or DMSO/water mixtures. The half-lives of GD in aqueous PVAm-APy were 12 and 770 min at pH 8.5 and 5, respectively. Addition of VX into 3.5-3.7 wt % suspensions of PVAm-APy in DMSO-d(6) and D2O at initial VX concentration of 0.2 vol % resulted in 100% VX degradation in less than 20 min. The unmodified PVAm and PAAm were 2 orders of magnitude less active than PVAm-APy and PAAm-APy, with VX half-lives in the range of 24 h. Furthermore, the PVAm-APy and PAAm-APy gels facilitated the dehydrochlorination reaction of sulfur mustard (HD) and its analogue 2-chloroethyl ethylsulfide (CEES). The ability of the reported aminopyridine-modified polyalkylamine materials to degrade the most persistent of CWAs, coupled with aqueous solubility, and the presence of numerous amino groups that provide convenient "handles" for covalent attachment on polymeric and inorganic supports yields promise for applications such as protective fabric and textile treatment and components of decontaminating materials.
C1 [Bromberg, Lev; Hatton, T. Alan] MIT, Dept Chem Engn, Cambridge, MA 02139 USA.
[Creasy, William R.] Leidos Corp, Gunpowder, MD 21010 USA.
[McGarvey, David J.] US Army Edgewood Chem & Biol Ctr, R&T Directorate, Analyt Toxicol Branch, Aberdeen Proving Ground, MD 21010 USA.
[Wilusz, Eugene] US Army Natick Soldier Res Dev & Engn Ctr, Mat Sci & Engn Branch, Natick, MA 01760 USA.
RP Hatton, TA (reprint author), MIT, Dept Chem Engn, Cambridge, MA 02139 USA.
EM tahatton@mit.edu
FU Defense Threat Reduction Agency; [W911SR-11-C-0047]
FX This work was supported by the Defense Threat Reduction Agency. Support
to Leidos was through Contract W911SR-11-C-0047.
NR 67
TC 4
Z9 4
U1 12
U2 60
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1944-8244
J9 ACS APPL MATER INTER
JI ACS Appl. Mater. Interfaces
PD OCT 7
PY 2015
VL 7
IS 39
BP 22001
EP 22011
DI 10.1021/acsami.5b06905
PG 11
WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary
SC Science & Technology - Other Topics; Materials Science
GA CT2JX
UT WOS:000362628900048
PM 26359671
ER
PT J
AU Brame, JA
Poda, AR
Kennedy, AJ
Steevens, JA
AF Brame, Jonathon A.
Poda, Aimee R.
Kennedy, Alan J.
Steevens, Jeffery A.
TI EHS Testing of Products Containing Nanomaterials: What is Nano Release?
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Editorial Material
C1 [Brame, Jonathon A.; Poda, Aimee R.; Kennedy, Alan J.; Steevens, Jeffery A.] US Army, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA.
RP Brame, JA (reprint author), US Army, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA.
EM jon.brame@gmail.com
RI Poda, Aimee/K-1905-2012
NR 5
TC 1
Z9 1
U1 1
U2 35
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
EI 1520-5851
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD OCT 6
PY 2015
VL 49
IS 19
BP 11245
EP 11246
DI 10.1021/acs.est.5b04173
PG 2
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA CT2JZ
UT WOS:000362629100001
PM 26373313
ER
PT J
AU Huang, YM
Rueda, LM
AF Huang, Yiau-Min
Rueda, Leopoldo M.
TI A pictorial key to the species of the Aedes (Zavortinkius) in the
Afrotropical Region (Diptera: Culicidae)
SO ZOOTAXA
LA English
DT Article
DE Culicidae; Aedes; mosquitoes; identification key; Africa
AB Six species of the subgenus Zavortinkius of Aedes Meigen in the Afrotropical Region are treated in a pictorial key based on diagnostic morphological features. Images of the diagnostic morphological structures of the adult thorax and leg are included.
C1 [Huang, Yiau-Min] Smithsonian Inst, Dept Entomol, Washington, DC 20013 USA.
[Rueda, Leopoldo M.] Walter Reed Army Inst Res, Entomol Branch, Walter Reed Biosystemat Unit, Silver Spring, MD 20910 USA.
RP Huang, YM (reprint author), Smithsonian Inst, Museum Support Ctr MRC 534, Walter Reed Biosystemat Unit, 4210 Silver Hill Rd, Suitland, MD 20746 USA.
EM huangy@si.edu; ruedapol@si.edu
NR 23
TC 0
Z9 0
U1 0
U2 1
PU MAGNOLIA PRESS
PI AUCKLAND
PA PO BOX 41383, AUCKLAND, ST LUKES 1030, NEW ZEALAND
SN 1175-5326
EI 1175-5334
J9 ZOOTAXA
JI Zootaxa
PD OCT 6
PY 2015
VL 4027
IS 4
BP 593
EP 599
PG 7
WC Zoology
SC Zoology
GA CS7PB
UT WOS:000362275400009
PM 26624200
ER
PT J
AU Twomey, PS
Smith, BL
McDermott, C
Novitt-Moreno, A
McCarthy, W
Kachur, SP
Arguin, PM
AF Twomey, Patrick S.
Smith, Bryan L.
McDermott, Cathy
Novitt-Moreno, Anne
McCarthy, William
Kachur, S. Patrick
Arguin, Paul M.
TI Intravenous Artesunate for the Treatment of Severe and Complicated
Malaria in the United States: Clinical Use Under an Investigational New
Drug Protocol
SO ANNALS OF INTERNAL MEDICINE
LA English
DT Article
ID SEVERE FALCIPARUM-MALARIA; INTENSIVE-CARE-UNIT; PLASMODIUM-FALCIPARUM;
RANDOMIZED-TRIAL; QUINIDINE; QUININE; ADULTS; RISK; ARTEMISININ;
MANAGEMENT
AB Background: Quinidine gluconate, the only U.S. Food and Drug Administration-approved treatment for life-threatening malaria in the United States, has a problematic safety profile and is often unavailable in hospitals.
Objective: To assess the safety and clinical benefit of intravenous artesunate as an alternative to quinidine.
Design: Retrospective case series.
Setting: U.S. hospitals.
Patients: 102 patients aged 1 to 72 years (90% adults; 61% men) with severe and complicated malaria. Patients received 4 weight-based doses of intravenous artesunate (2.4 mg/kg) under a treatment protocol implemented by the Centers for Disease Control and Prevention between January 2007 and December 2010. At baseline, 35% had evidence of cerebral malaria, and 17% had severe hepatic impairment. Eligibility required the presence of microscopically confirmed malaria, need for intravenous treatment, and an impediment to quinidine.
Measurements: Clinical and laboratory data from each patient's hospital records were abstracted retrospectively, including information from baseline through a maximum 7-day follow-up, and presented before a physician committee to evaluate safety and clinical benefit outcomes.
Results: 7 patients died (mortality rate, 6.9%). The most frequent adverse events were anemia (65%) and elevated hepatic enzyme levels (49%). All deaths and most adverse events were attributed to the severity of malaria. Patients' symptoms generally improved or resolved within 3 days, and the median time to discharge from the intensive care unit was 4 days, even for patients with severe liver disease or cerebral malaria. More than 100 concomitant medications were used, with no documented drug-drug interactions.
Limitation: Potential late-presenting safety issues might occur outside the 7-day follow-up.
Conclusion: Artesunate was a safe and clinically beneficial alternative to quinidine.
C1 [Twomey, Patrick S.] US Army Med Mat Dev Act, Ft Detrick, MD 21702 USA.
Fast Track Drugs & Biol, North Potomac, MD USA.
Ctr Dis Control & Prevent, Bethesda, MD USA.
RP Twomey, PS (reprint author), US Army Med Mat Dev Act, 1430 Vet Dr, Ft Detrick, MD 21702 USA.
EM patrick.s.twomey.mil@mail.mil
FU Office of the Surgeon General, Department of the U.S. Army
FX Office of the Surgeon General, Department of the U.S. Army.
NR 44
TC 4
Z9 4
U1 2
U2 11
PU AMER COLL PHYSICIANS
PI PHILADELPHIA
PA INDEPENDENCE MALL WEST 6TH AND RACE ST, PHILADELPHIA, PA 19106-1572 USA
SN 0003-4819
EI 1539-3704
J9 ANN INTERN MED
JI Ann. Intern. Med.
PD OCT 6
PY 2015
VL 163
IS 7
BP 498
EP +
DI 10.7326/M15-0910
PG 11
WC Medicine, General & Internal
SC General & Internal Medicine
GA CT0OQ
UT WOS:000362496400003
PM 26301474
ER
PT J
AU Svenkeson, A
Swami, A
AF Svenkeson, A.
Swami, A.
TI Reaching Consensus by Allowing Moments of Indecision
SO SCIENTIFIC REPORTS
LA English
DT Article
ID OPINION DYNAMICS; ZEALOTS; PHYSICS; MINORITIES; EVOLUTION
AB Group decision-making processes often turn into a drawn out and costly battle between two opposing subgroups. Using analytical arguments based on a master equation description of the opinion dynamics occurring in a three-state model of cooperatively interacting units, we show how the capability of a social group to reach consensus can be enhanced when there is an intermediate state for indecisive individuals to pass through. The time spent in the intermediate state must be relatively short compared to that of the two polar states in order to create the beneficial effect. Furthermore, the cooperation between individuals must not be too low, as the benefit to consensus is possible only when the cooperation level exceeds a specific threshold. We also discuss how zealots, agents that remain in one state forever, can affect the consensus among the rest of the population by counteracting the benefit of the intermediate state or making it virtually impossible for an opposition to form.
C1 [Svenkeson, A.; Swami, A.] Army Res Lab, Adelphi, MD 20783 USA.
RP Svenkeson, A (reprint author), Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM adam.svenkeson@gmail.com
NR 40
TC 3
Z9 3
U1 0
U2 4
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD OCT 6
PY 2015
VL 5
AR 14839
DI 10.1038/srep14839
PG 9
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CS7QC
UT WOS:000362278800001
PM 26439503
ER
PT J
AU Fleyer, M
Cahill, JP
Horowitz, M
Menyuk, CR
Okusaga, O
AF Fleyer, Michael
Cahill, James P.
Horowitz, Moshe
Menyuk, Curtis R.
Okusaga, Olukayode
TI Comprehensive model for studying noise induced by self-homodyne
detection of backward Rayleigh scattering in optical fibers
SO OPTICS EXPRESS
LA English
DT Article
ID DENSITY-FLUCTUATIONS; K2O-SIO2 GLASSES; BACKSCATTERING; DISPERSION;
SYSTEMS; BIREFRINGENCE; LIMIT
AB Backward Rayleigh scattering in optical fibers due to the fluctuations that are "frozen-in" to the fiber during the manufacturing process may limit the performance of optical sensors and bidirectional coherent optical communication systems. In this manuscript we describe a comprehensive model for studying intensity noise induced by spontaneous Rayleigh backscattering in optical systems that are based on self-homodyne detection. Our model includes amplitude and frequency noise of the laser source, random distribution of the scatterers along the fiber, and phase noise induced in fibers due to thermal and mechanical fluctuations. The model shows that at frequencies above about 10 kHz the noise spectrum is determined by the laser white frequency noise. The laser flicker frequency noise becomes the dominant effect at lower frequencies. The noise amplitude depends on the laser polarization. A very good agreement between theory and experiment is obtained for fibers with a length between 500 m to 100 km and for a laser with a linewidth below 5 kHz. (C) 2015 Optical Society of America.
C1 [Fleyer, Michael; Horowitz, Moshe] Technion Israel Inst Technol, IL-3200 Haifa, Israel.
[Cahill, James P.; Menyuk, Curtis R.] Univ Maryland Baltimore Cty, Baltimore, MD 21250 USA.
[Cahill, James P.] US Army, Res Lab, Adelphi, MD 20873 USA.
[Okusaga, Olukayode] Johns Hopkins Univ, Appl Phys Lab, Laurel, MD 20723 USA.
RP Fleyer, M (reprint author), Technion Israel Inst Technol, IL-3200 Haifa, Israel.
EM mikef@tx.technion.ac.il
FU Israel Science Foundation (ISF) of the Israeli Academy of Sciences
[1092/10]; Army Research Laboratory
FX Work at the Technion was supported by the Israel Science Foundation
(ISF) of the Israeli Academy of Sciences (grant No. 1092/10). Work at
the UMBC was supported by the Army Research Laboratory.
NR 46
TC 2
Z9 2
U1 3
U2 6
PU OPTICAL SOC AMER
PI WASHINGTON
PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA
SN 1094-4087
J9 OPT EXPRESS
JI Opt. Express
PD OCT 5
PY 2015
VL 23
IS 20
BP 25635
EP 25652
DI 10.1364/OE.23.025635
PG 18
WC Optics
SC Optics
GA CW6AD
UT WOS:000365077900022
PM 26480080
ER
PT J
AU Tabiryan, NV
Serak, SV
Roberts, DE
Steeves, DM
Kimball, BR
AF Tabiryan, Nelson V.
Serak, Svetlana V.
Roberts, David E.
Steeves, Diane M.
Kimball, Brian R.
TI Thin waveplate lenses of switchable focal length - new generation in
optics
SO OPTICS EXPRESS
LA English
DT Article
ID LIQUID-CRYSTAL LENS; POLARIZATION GRATINGS; HIGH-EFFICIENCY;
DIFFRACTION; BEAM
AB We present new lenses - waveplate lenses created in liquid crystal and liquid crystal polymer materials. Using an electrically-switchable liquid-crystal half-wave retarder we realized switching between focused and defocused beams by the waveplate lens. A combination of two such lenses allowed the collimation of a laser beam as well as the change of focal length of optical system. (C) 2015 Optical Society of America
C1 [Tabiryan, Nelson V.; Serak, Svetlana V.; Roberts, David E.] BEAM Co, Orlando, FL 32810 USA.
[Steeves, Diane M.; Kimball, Brian R.] US Army, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA.
RP Tabiryan, NV (reprint author), BEAM Co, 1300 Lee Rd, Orlando, FL 32810 USA.
EM nelson@beamco.com
FU US Army Natick Soldier Research, Development and Engineering Center
FX The work was supported by funding from US Army Natick Soldier Research,
Development and Engineering Center. We thank Dr. S. Nersisyan and Dr. H.
Xianyu for assistance with LCP coating.
NR 26
TC 5
Z9 5
U1 4
U2 14
PU OPTICAL SOC AMER
PI WASHINGTON
PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA
SN 1094-4087
J9 OPT EXPRESS
JI Opt. Express
PD OCT 5
PY 2015
VL 23
IS 20
BP 25783
EP 25794
DI 10.1364/OE.23.025783
PG 12
WC Optics
SC Optics
GA CW6AD
UT WOS:000365077900034
PM 26480092
ER
PT J
AU Segercrantz, N
Yu, KM
Ting, M
Sarney, WL
Svensson, SP
Novikov, SV
Foxon, CT
Walukiewicz, W
AF Segercrantz, N.
Yu, K. M.
Ting, M.
Sarney, W. L.
Svensson, S. P.
Novikov, S. V.
Foxon, C. T.
Walukiewicz, W.
TI Electronic band structure of highly mismatched GaN1-xSbx alloys in a
broad composition range
SO APPLIED PHYSICS LETTERS
LA English
DT Article
ID ENERGY
AB In this letter, we study the optical properties of GaN1-xSbx thin films. Films with an Sb fraction up to 42% were synthesized by alternating GaN-GaSb layers at a constant temperature of 325 degrees C. The measured optical absorption data of the films are interpreted using a modified band anticrossing model that is applicable to highly mismatched alloys such as GaN1-xSbx in the entire composition range. The presented model allows us to more accurately determine the band gap as well as the band edges over the entire composition range thereby providing means for determining the composition for; e.g.; efficient spontaneous photoelectrochemical cell applications. (C) 2015 AIP Publishing LLC.
C1 [Segercrantz, N.] Aalto Univ, Dept Appl Phys, FIN-00076 Aalto Espoo, Finland.
[Segercrantz, N.; Yu, K. M.; Ting, M.; Walukiewicz, W.] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Div Mat Sci, Berkeley, CA 94720 USA.
[Yu, K. M.] City Univ Hong Kong, Dept Phys & Mat Sci, Kowloon, Hong Kong, Peoples R China.
[Ting, M.] Univ Calif Berkeley, Dept Mech Engn, Berkeley, CA 94720 USA.
[Sarney, W. L.; Svensson, S. P.] US Army Res Lab, Adelphi, MD 20783 USA.
[Novikov, S. V.; Foxon, C. T.] Univ Nottingham, Sch Phys & Astron, Nottingham NG7 2RD, England.
RP Segercrantz, N (reprint author), Aalto Univ, Dept Appl Phys, POB 14100, FIN-00076 Aalto Espoo, Finland.
EM natalie.segercrantz@aalto.fi
RI Segercrantz, Natalie/A-7316-2016
OI Segercrantz, Natalie/0000-0001-5734-3264
FU Office of Science, Office of Basic Energy Sciences, Materials Sciences
and Engineering Division, of the U.S. Department of Energy
[DE-AC02-05CH11231]
FX RBS. optical measurements and the data analysis performed at LBNL were
supported by the Director, Office of Science, Office of Basic Energy
Sciences, Materials Sciences and Engineering Division, of the U.S.
Department of Energy under Contract No. DE-AC02-05CH11231. The sample
growth was performed by U.S. Army Research Laboratory.
NR 33
TC 5
Z9 5
U1 2
U2 7
PU AMER INST PHYSICS
PI MELVILLE
PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA
SN 0003-6951
EI 1077-3118
J9 APPL PHYS LETT
JI Appl. Phys. Lett.
PD OCT 5
PY 2015
VL 107
IS 14
AR 142104
DI 10.1063/1.49325921
PG 4
WC Physics, Applied
SC Physics
GA CU3JV
UT WOS:000363422100033
ER
PT J
AU La Scala, J
Stanzione, JF
AF La Scala, John
Stanzione, Joseph F., III
TI Richard P. Wool, PhD, Professor, FRSC In memoriam
SO JOURNAL OF APPLIED POLYMER SCIENCE
LA English
DT Editorial Material
C1 [La Scala, John] US Army Res Lab, Coatings Corros & Engn Polymers Branch, Aberdeen Proving Ground, MD USA.
[La Scala, John] US Army Res Lab, Aberdeen Proving Ground, MD USA.
[Stanzione, Joseph F., III] Rowan Univ, Chem Engn, Glassboro, NJ USA.
[Stanzione, Joseph F., III] Rowan Univ, Sustainable Mat Res Labs, Glassboro, NJ USA.
RP La Scala, J (reprint author), US Army Res Lab, Coatings Corros & Engn Polymers Branch, Aberdeen Proving Ground, MD USA.
NR 0
TC 1
Z9 1
U1 5
U2 11
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-8995
EI 1097-4628
J9 J APPL POLYM SCI
JI J. Appl. Polym. Sci.
PD OCT 5
PY 2015
VL 132
IS 37
AR 42525
DI 10.1002/app.42525
PG 1
WC Polymer Science
SC Polymer Science
GA CM2QG
UT WOS:000357525900010
ER
PT J
AU Whitehouse, CA
Bavari, S
Perkins, MD
AF Whitehouse, Chris A.
Bavari, Sina
Perkins, Mark D.
TI United States FDA's emergency use authorization of Ebola virus
diagnostics: current impact and lessons for the future
SO EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
LA English
DT Editorial Material
DE assays; diagnostics; Ebola; filoviruses; regulation; viral outbreaks
AB The Ebola outbreak that took hold in West Africa in 2014 outran the epidemic response capacity of many organizations. Five months after the epidemic was first declared, there were still only two laboratories in West Africa with the capacity to confirm Ebola virus infection. In the summer of 2014, before the first case of imported Ebola occurred in the USA, the US FDA announced it would issue Emergency Use Authorizations for Ebola virus in vitro diagnostics to speed their availability. Between October 2014 and March 2015, the FDA issued Emergency Use Authorizations for nine diagnostic products. The actions of the FDA not only allowed nationwide deployment of Ebola virus testing capacity in the USA but also established an attractive regulatory goalpost for companies developing assays for use in West Africa. Here, we comment on the diagnostic assays for which the FDA has issued emergency authorizations and their fitness for purpose.
C1 [Perkins, Mark D.] Fdn Innovat New Diagnost, 9 Chemin Mines, Geneva, Switzerland.
[Whitehouse, Chris A.; Bavari, Sina] US Army, Med Res Inst Infect Dis, Mol & Translat Sci Div, Ft Detrick, MD 21702 USA.
RP Perkins, MD (reprint author), Fdn Innovat New Diagnost, 9 Chemin Mines, Geneva, Switzerland.
EM Mark.Perkins@finddx.org
NR 15
TC 1
Z9 1
U1 2
U2 4
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1473-7159
EI 1744-8352
J9 EXPERT REV MOL DIAGN
JI Expert Rev. Mol. Diagn.
PD OCT 3
PY 2015
VL 15
IS 10
BP 1231
EP 1235
DI 10.1586/14737159.2015.1077117
PG 5
WC Pathology
SC Pathology
GA DC5TJ
UT WOS:000369283000001
PM 26394699
ER
PT J
AU Erol, O
Wetzel, ED
Keefe, M
AF Erol, Ozan
Wetzel, Eric D.
Keefe, Michael
TI Simulation of a textile sleeve on a manikin arm undergoing elbow
flexion: effect of arm-sleeve friction
SO JOURNAL OF THE TEXTILE INSTITUTE
LA English
DT Article
DE friction effects; Kevlar; protective garment design; textile modeling
ID BALLISTIC IMPACT; MECHANICAL-BEHAVIOR; CONSTITUTIVE MODEL; WOVEN
FABRICS; FIBER; COMFORT
AB The effect of friction on the interaction between a protective fabric sleeve and a manikin arm undergoing elbow flexion has been investigated both numerically and experimentally. The experimental studies used a cylindrical Kevlar sleeve on the right arm of a Hybrid III crash-test dummy. A load frame was used to produce elbow flexion and to measure the force required to produce that motion. Friction was varied by performing the elbow flexion task with and without a tight-fitting white knit polyester undergarment, and friction coefficients were determined experimentally. Corresponding numerical simulations using LS-DYNA were also performed, with the textile sleeve represented by orthotropic shell elements with geometric non-linearity based on experimental literature data. The results show that the presence of the Kevlar sleeve significantly increases the force required to execute elbow flexion, but that the addition of the friction-reducing undergarment reduces the flexion force generated by the Kevlar sleeve. Furthermore, this behavior can be effectively captured by the numerical simulation. These results demonstrate the possibility of direct simulation of the mechanical burden generated by protective clothing, which could lead to computational design of protective garments with improved comfort, and reduced reliance on human subject testing.
C1 [Erol, Ozan; Keefe, Michael] Univ Delaware, Dept Mech Engn, Newark, DE 19716 USA.
[Wetzel, Eric D.] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen, MD USA.
RP Erol, O (reprint author), Univ Delaware, Dept Mech Engn, Newark, DE 19716 USA.
EM ozanerol@udel.edu
OI Erol, Ozan/0000-0002-0505-4193
NR 32
TC 1
Z9 1
U1 2
U2 14
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0040-5000
EI 1754-2340
J9 J TEXT I
JI J. Text. Inst.
PD OCT 3
PY 2015
VL 106
IS 10
BP 1135
EP 1146
DI 10.1080/00405000.2014.977523
PG 12
WC Materials Science, Textiles
SC Materials Science
GA CP4FO
UT WOS:000359837600012
ER
PT J
AU de Rosset, WS
AF de Rosset, William S.
TI Processing of Composite Gun Tubes with GLEEM and Hammer Forging
SO MATERIALS AND MANUFACTURING PROCESSES
LA English
DT Article
DE Gun; Niobium; Elastomer; Hammer-forge; Liner; Composite; Firing
AB Refractory metal liners have been shown to extend the service life of gun tubes a considerable amount. The major technical hurdle to date has been keeping the liners in place during firing. To address this problem, composite gun tubes made of steel and pure niobium have been fabricated through a combination of the GLEEM (gun liner emplacement with an elastomeric material) and the hammer forging. The three barrels made by this approach were test fired in single-shot and burst-fire mode. One of the barrels whose liner had been cold-sprayed with tungsten carbide particles before the GLEEM process showed no liner movement in any of the tests. The success of this new liner processing technology to prevent liner movement offers the potential for further investigations of refractory metals that are more suitable as liner materials.
C1 US Army Res Lab, Lightweight & Specialty Met Branch, RDRL WMM F, Aberdeen, MD USA.
RP de Rosset, WS (reprint author), US Army Res Lab, Lightweight & Specialty Met Branch, RDRL WMM F, Aberdeen, MD USA.
EM william.s.derosset.ctr@mail.mil
FU U.S. Department of Energy; USARL
FX This research was supported in part by an appointment to the Knowledge
Preservation Program at the United States Army Research Laboratory
(USARL) administered by the Oak Ridge Institute for Science and
Education through an interagency agreement between the U.S. Department
of Energy and USARL.
NR 12
TC 0
Z9 0
U1 2
U2 13
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1042-6914
EI 1532-2475
J9 MATER MANUF PROCESS
JI Mater. Manuf. Process.
PD OCT 3
PY 2015
VL 30
IS 10
BP 1168
EP 1173
DI 10.1080/10426914.2015.1026352
PG 6
WC Engineering, Manufacturing; Materials Science, Multidisciplinary
SC Engineering; Materials Science
GA CM5NH
UT WOS:000357734500002
ER
PT J
AU Wang, YQ
Lucas, G
Khooshabeh, P
de Melo, C
Gratch, J
AF Wang, Yuqiong
Lucas, Gale
Khooshabeh, Peter
de Melo, Celso
Gratch, Jonathan
TI Effects of emotional expressions on persuasion
SO SOCIAL INFLUENCE
LA English
DT Article
DE persuasion; emotion; expression; power; appropriateness
ID DECISION-MAKING; ANGER; LEADERS; POWER; PERFORMANCE; FOLLOWERS;
CONTAGION; HAPPINESS; DISPLAY; SMILE
AB This paper investigates how expressions of emotion affect persuasiveness when the expresser and the recipient have different levels of power. The first study demonstrates that when the recipient overpowers the expresser, emotional expressions reduce persuasion. A second study reveals that power and perceived appropriateness of emotional expressions independently moderate the effect of emotional expressions. Emotional expressions hamper persuasion when the recipient overpowers the expresser, or when the emotional expressions are considered inappropriate.
C1 [Wang, Yuqiong; Lucas, Gale; Khooshabeh, Peter; de Melo, Celso; Gratch, Jonathan] Univ So Calif, Inst Creat Technol, Playa Vista, CA USA.
[Khooshabeh, Peter] Army Res Lab, Human Res & Engn Directorate, Aberdeen, MD USA.
RP Wang, YQ (reprint author), Univ So Calif, Inst Creat Technol, Playa Vista, CA USA.
EM wangyuqiong@ymail.com
NR 24
TC 0
Z9 0
U1 2
U2 7
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 1553-4510
EI 1553-4529
J9 SOC INFLUENCE
JI Soc. Influ.
PD OCT 2
PY 2015
VL 10
IS 4
BP 236
EP 249
DI 10.1080/15534510.2015.1081856
PG 14
WC Psychology, Social
SC Psychology
GA CY5SS
UT WOS:000366468300005
ER
PT J
AU Wei, MH
Li, BY
David, RLA
Jones, SC
Sarohia, V
Schmitigal, JA
Kornfield, JA
AF Wei, Ming-Hsin
Li, Boyu
David, R. L. Ameri
Jones, Simon C.
Sarohia, Virendra
Schmitigal, Joel A.
Kornfield, Julia A.
TI Megasupramolecules for safer, cleaner fuel by end association of long
telechelic polymers
SO SCIENCE
LA English
DT Article
ID SUPRAMOLECULAR POLYMERS; POLYMERIZATION; EQUILIBRIA; COMPLEXES
AB We used statistical mechanics to design polymers that defy conventional wisdom by self-assembling into "megasupramolecules" (>= 5000 kg/mol) at low concentration (<= 0.3 weight percent). Theoretical treatment of the distribution of individual subunits-end-functional polymers-among cyclic and linear supramolecules (ring-chain equilibrium) predicts that megasupramolecules can format lowtotal polymer concentration if, and only if, the backbones are long (> 400 kg/mol) and end-association strength is optimal. Viscometry and scattering measurements of long telechelic polymers having polycyclooctadiene backbones and acid or amine end groups verify the formation of megasupramolecules. They control misting and reduce drag in the same manner as ultralong covalent polymers. With individual building blocks short enough to avoid hydrodynamic chain scission (weight-average molecular weights of 400 to 1000 kg/mol) and reversible linkages that protect covalent bonds, these megasupramolecules overcome the obstacles of shear degradation and engine incompatibility.
C1 [Wei, Ming-Hsin; Li, Boyu; David, R. L. Ameri; Kornfield, Julia A.] CALTECH, Div Chem & Chem Engn, Pasadena, CA 91125 USA.
[Jones, Simon C.] CALTECH, Jet Prop Lab, Electrochem Technol Grp, Pasadena, CA 91109 USA.
[Sarohia, Virendra] CALTECH, Jet Prop Lab, Off Chief Technologist, Pasadena, CA 91109 USA.
[Schmitigal, Joel A.] US Army RDECOM TARDEC, Warren, MI 48397 USA.
RP Kornfield, JA (reprint author), CALTECH, Div Chem & Chem Engn, Pasadena, CA 91125 USA.
EM jakornfield@cheme.caltech.edu
OI Li, Boyu/0000-0002-7648-3745
FU U.S. Army TARDEC; FAA; NASA [NAS7-03001]; Gates Grubstake Fund;
Schlumberger Foundation
FX Funding for this research was provided from U.S. Army TARDEC, FAA, and
NASA (NAS7-03001) and the Gates Grubstake Fund. B.L. is grateful for
support from the Schlumberger Foundation Faculty for the Future Program.
We thank P. Arakelian (GALCIT) and T. Wynne (JPL) for assistance with
the fuel impact tests; B. Hammouda (NIST) and L. He (ORNL) for
assistance with SANS; T. Durbin, R. Russell, D. Pacocha, and K. Bumiller
at UCR CE-CERT for assistance with engine tests; A. Meyer at Wyatt
Technology and Caltech graduate student J. Kim for assistance with
MALLS; and Caltech undergraduates S. Li and A. Guo for assistance with
shear degradation tests and rheological measurements. A patent
application (WO/2014/145920) based on some results reported here has
been submitted.
NR 30
TC 9
Z9 9
U1 15
U2 57
PU AMER ASSOC ADVANCEMENT SCIENCE
PI WASHINGTON
PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA
SN 0036-8075
EI 1095-9203
J9 SCIENCE
JI Science
PD OCT 2
PY 2015
VL 350
IS 6256
BP 72
EP 75
DI 10.1126/science.aab0642
PG 4
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CS5EA
UT WOS:000362098300047
PM 26430115
ER
PT J
AU Bozue, JA
Welkos, S
Cote, CK
AF Bozue, Joel A.
Welkos, Susan
Cote, Christopher K.
TI The Bacillus anthracis Exosporium: What's the Big "Hairy" Deal?
SO MICROBIOLOGY SPECTRUM
LA English
DT Article
ID SUBTILIS SPORE COAT; SURFACE PROTEIN BCLA; COLLAGEN-LIKE REGION;
EPITHELIAL-CELLS; INHALATIONAL ANTHRAX; PROTECTIVE ANTIGEN; CEREUS
SPORES; IMMUNODOMINANT PROTEIN; INACTIVATED SPORES; SUBOPTIMAL AMOUNTS
AB In some Bacillus species, including Bacillus subtilis, the coat is the outermost layer of the spore. In others, such as the Bacillus cereus family, there is an additional layer that envelops the coat, called the exosporium. In the case of Bacillus anthracis, a series of fine hair-like projections, also referred to as a "hairy" nap, extends from the exosporium basal layer. The exact role of the exosporium in B. anthracis, or for any of the Bacillus species possessing this structure, remains unclear. However, it has been assumed that the exosporium would play some role in infection for B. anthracis, because it is the outermost structure of the spore and would make initial contact with host and immune cells during infection. Therefore, the exosporium has been a topic of great interest, and over the past decade much progress has been made to understand its composition, biosynthesis, and potential roles. Several key aspects of this spore structure, however, are still debated and remain undetermined. Although insights have been gained on the interaction of exosporium with the host during infection, the exact role and significance of this complex structure remain to be determined. Furthermore, because the exosporium is a highly antigenic structure, future strategies for the next-generation anthrax vaccine should pursue its inclusion as a component to provide protection against the spore itself during the initial stages of anthrax.
C1 [Bozue, Joel A.; Welkos, Susan; Cote, Christopher K.] US Army, Med Res Inst Infect Dis, Div Bacteriol, Ft Detrick, MD 21702 USA.
RP Bozue, JA (reprint author), US Army, Med Res Inst Infect Dis, Div Bacteriol, Ft Detrick, MD 21702 USA.
EM joel.a.bozue.civ@mail.mil
NR 109
TC 1
Z9 1
U1 3
U2 3
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
EI 2165-0497
J9 MICROBIOL SPECTR
JI Microbiol. Spectr.
PD OCT
PY 2015
VL 3
IS 5
AR UNSP TBS-0021-2015
DI 10.1128/microbiolspec.TBS-0021-2015
PG 15
WC Microbiology
SC Microbiology
GA DT9EP
UT WOS:000381798900007
ER
PT J
AU Bove, A
Smith, K
Bise, C
Fritz, J
Childs, J
Brennan, GP
Abbott, JH
Fitzgerald, GK
AF Bove, Allyn
Smith, Ken
Bise, Christopher
Fritz, Julie
Childs, John
Brennan, Gerard P.
Abbott, J. Haxby
Fitzgerald, G. Kelley
TI What Is the Most Cost-Effective Physical Therapy Strategy to Treat Knee
Osteoarthritis?
SO ARTHRITIS & RHEUMATOLOGY
LA English
DT Meeting Abstract
C1 [Bove, Allyn; Bise, Christopher; Fitzgerald, G. Kelley] Univ Pittsburgh, Phys Therapy, Pittsburgh, PA USA.
[Smith, Ken] Univ Pittsburgh, Div Internal Med, Pittsburgh, PA USA.
[Smith, Ken] Univ Pittsburgh, Inst Clin Res Educ, Pittsburgh, PA USA.
[Fritz, Julie] Univ Utah, Dept Phys Therapy, Salt Lake City, UT USA.
[Childs, John] Baylor Univ, US Army, Schertz, TX USA.
[Brennan, Gerard P.] Intermt Healthcare, Rehabil Serv, Murray, UT USA.
[Abbott, J. Haxby] Univ Otago, Dept Surg Sci, Ctr Musculoskeletal Outcomes Res, Dunedin, New Zealand.
RI Abbott, J./B-2976-2008
OI Abbott, J./0000-0001-6468-7284
NR 2
TC 0
Z9 0
U1 1
U2 3
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2326-5191
EI 2326-5205
J9 ARTHRITIS RHEUMATOL
JI Arthritis Rheumatol.
PD OCT
PY 2015
VL 67
SU 10
MA 1001
PG 2
WC Rheumatology
SC Rheumatology
GA DE8BG
UT WOS:000370860202265
ER
PT J
AU Torralba, KMD
Cannella, AC
Kissin, EY
Bolster, MB
Higgs, JB
Samuels, J
Nishio, MJ
Kaeley, GS
Evangelisto, AM
DeMarco, PJ
Kohler, MJ
AF Torralba, Karina Marianne D.
Cannella, Amy C.
Kissin, Eugene Y.
Bolster, Marcy B.
Higgs, Jay B.
Samuels, Jonathan
Nishio, Midori Jane
Kaeley, Gurjit S.
Evangelisto, Amy M.
DeMarco, Paul J.
Kohler, Minna J.
TI Musculoskeletal Ultrasound Education Among Rheumatology Fellowship
Programs in the United States
SO ARTHRITIS & RHEUMATOLOGY
LA English
DT Meeting Abstract
C1 [Torralba, Karina Marianne D.] Loma Linda Univ, Dept Internal Med, Div Rheumatol, Loma Linda, CA 92350 USA.
[Cannella, Amy C.] Univ Nebraska Med Ctr, Sect Rheumatol, Omaha, NE USA.
[Kissin, Eugene Y.] Boston Univ, Sch Med, Boston, MA 02118 USA.
[Bolster, Marcy B.] Massachusetts Gen Hosp, Boston, MA 02114 USA.
[Higgs, Jay B.] Brooke Army Med Ctr, Rheumatol Serv, San Antonio, TX USA.
[Samuels, Jonathan] NYU, Hosp Joint Dis, Rheumatol, New York, NY USA.
[Kaeley, Gurjit S.] Univ Florida, Coll Med, Rheumatol, Jacksonville, FL USA.
[Evangelisto, Amy M.] Arthrit Rheumat & Back Dis Associates, Voorhees, NJ USA.
[DeMarco, Paul J.] Arthrit & Rheumatism Assoc PC, Wheaton, MD USA.
[Kohler, Minna J.] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Rheumatol Allergy & Immunol, Boston, MA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2326-5191
EI 2326-5205
J9 ARTHRITIS RHEUMATOL
JI Arthritis Rheumatol.
PD OCT
PY 2015
VL 67
SU 10
MA 1186
PG 2
WC Rheumatology
SC Rheumatology
GA DE8BG
UT WOS:000370860202450
ER
PT J
AU Zhang, M
Pessina, M
Higgs, JB
Kissin, EY
AF Zhang, MaryAnn
Pessina, Monica
Higgs, Jay B.
Kissin, Eugene Y.
TI A Vascular Obstacle in Ultrasound Guided Hip Joint Injection
SO ARTHRITIS & RHEUMATOLOGY
LA English
DT Meeting Abstract
C1 [Zhang, MaryAnn] Boston Univ, Sch Med, Internal Med, Boston, MA 02118 USA.
[Pessina, Monica] Boston Univ, Sch Med, Anat, Boston, MA 02118 USA.
[Higgs, Jay B.] Brooke Army Med Ctr, Rheumatol Serv, San Antonio, TX USA.
[Kissin, Eugene Y.] Boston Univ, Sch Med, Boston, MA 02118 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2326-5191
EI 2326-5205
J9 ARTHRITIS RHEUMATOL
JI Arthritis Rheumatol.
PD OCT
PY 2015
VL 67
SU 10
MA 181
PG 2
WC Rheumatology
SC Rheumatology
GA DE8BG
UT WOS:000370860201179
ER
PT J
AU Mcgowan, T
AF Mcgowan, Tony
TI Melville's Low-Relief Officer Corps
SO LEVIATHAN-A JOURNAL OF MELVILLE STUDIES
LA English
DT Article
AB This essay looks into Battle-Pieces and Aspects of the War (1866) to explore Melville's poetics of counter-hagiography within single and clustered poems on Civil War officers: Hancock and Grant, Sheridan and Sherman, Lyon, Lee and McClellan, and Bartlett. Keeping close to scholarship on the status of heroes and heroism in Melville's war poetry, I aim through close reading to elucidate Melville's strategies for subtly undoing heroism even within his ostensibly hero-making poems. At the advent of peace, I argue, Melville's officer poems refigure the ancient rites of praise charged to the war poet and introduce knowledge corrosive to the nation's too-ardent wartime reliance on the theory of great men.
C1 [Mcgowan, Tony] US Mil Acad, West Point, NY 10996 USA.
RP Mcgowan, T (reprint author), US Mil Acad, West Point, NY 10996 USA.
NR 37
TC 0
Z9 0
U1 0
U2 0
PU JOHNS HOPKINS UNIV PRESS
PI BALTIMORE
PA JOURNALS PUBLISHING DIVISION, 2715 NORTH CHARLES ST, BALTIMORE, MD
21218-4363 USA
SN 1525-6995
EI 1750-1849
J9 LEVIATHAN-J MELVILLE
JI Leviathan
PD OCT
PY 2015
VL 17
IS 3
SI SI
BP 43
EP 62
DI 10.1353/lvn.2015.0049
PG 20
WC Literature, American
SC Literature
GA DD4LC
UT WOS:000369893400004
ER
PT J
AU Ruhl, DS
Littlefield, PD
AF Ruhl, Douglas S.
Littlefield, Philip D.
TI Updates in medical malpractice: an otology perspective
SO CURRENT OPINION IN OTOLARYNGOLOGY & HEAD AND NECK SURGERY
LA English
DT Review
DE expert witness; litigation; medical malpractice; otologic surgery
ID CLINICAL-PRACTICE GUIDELINE; EXPERT WITNESS TESTIMONY; HEARING-LOSS;
UNITED-STATES; LITIGATION; OTOLARYNGOLOGY; LIABILITY; SURGERY;
PHYSICIANS; TRIALS
AB Purpose of review
Most surgeons at some point are involved in a medical malpractice case. There has been an increase in the number of manuscripts that analyse malpractice databases and insurance claims, as well as commentaries on the current medicolegal climate recently. This manuscript broadly reviews articles of interest to all providers and then focuses on malpractice in otology.
Recent findings
Medical malpractice articles (particularly topics related to otologic surgery published within the last 1-2 years) were searched. The growing body of literature can be divided into the themes of general negligence, mitigating injuries and the use of clinical practice guidelines in the courtroom as guidance for expert witnesses.
Summary
Recent findings suggest that the frequency of malpractice claims may be decreasing. Hearing loss and facial nerve injury are the most common injuries associated with otologic surgery. These injuries can be costly when negligence is found. Clinic practice guidelines are slowly being used as evidence in the courtroom and there are established guidelines that an expert witness must follow should a surgeon be called to give testimony.
C1 [Ruhl, Douglas S.; Littlefield, Philip D.] Tripler Army Med Ctr, Dept Otolaryngol Head & Neck Surg, Honolulu, HI 96859 USA.
RP Ruhl, DS (reprint author), Tripler Army Med Ctr, Dept Otolaryngol Head & Neck Surg, Attn MCHK DSH, 1 Jarrett White Rd, Honolulu, HI 96859 USA.
EM douglas.s.ruhl.mil@mail.mil
NR 38
TC 0
Z9 0
U1 1
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1068-9508
EI 1531-6998
J9 CURR OPIN OTOLARYNGO
JI Curr. Opin. Otolaryngol. Head Neck Surg.
PD OCT
PY 2015
VL 23
IS 5
BP 348
EP 354
DI 10.1097/MOO.0000000000000182
PG 7
WC Otorhinolaryngology
SC Otorhinolaryngology
GA DC7QX
UT WOS:000369416400004
PM 26339965
ER
PT J
AU Cage, JM
Knox, JB
Wimberly, RL
Shaha, S
Jo, C
Riccio, AI
AF Cage, Jason M.
Knox, Jeffrey B.
Wimberly, Robert L.
Shaha, Steve
Jo, ChanHee
Riccio, Anthony I.
TI Complications Associated With High-dose Corticosteroid Administration in
Children With Spinal Cord Injury
SO JOURNAL OF PEDIATRIC ORTHOPAEDICS
LA English
DT Article
DE spinal cord injury; pediatric; high-dose steroids; complication;
methylprednisolone; infection; trauma
ID METHYLPREDNISOLONE SODIUM SUCCINATE; RANDOMIZED CONTROLLED-TRIAL;
TIRILAZAD MESYLATE; PEPTIC-ULCER; FOLLOW-UP; THERAPY; RECOVERY;
STEROIDS; NALOXONE; IMPROVE
AB Background: Complications with high-dose steroid administration for spinal cord injury are documented in adult patients. Our purpose was to determine the incidence of early complications of this therapy in pediatric patients with spinal cord injuries.
Methods: An IRB-approved retrospective review was performed for patients treated for spinal cord injury at a level 1 pediatric trauma center between 2003 and 2011. Demographic data, injury characteristics, and surgical interventions were documented. Complications were divided into 4 categories: infectious, gastrointestinal (GI), hyperglycemia/endocrine, and wound healing problems. Complication rates were compared using a Student's t test and Fischer's exact test.
Results: Thirty-four spinal cord injury patients were identified. Twenty-three patients (mean age 6.6 y) in the treatment group received high-dose steroid treatment and 11 patients (mean age 8.4 y) did not and comprised the control group. No statistical difference was detected between the 2 groups regarding age, mechanism of injury, rate of surgical intervention, level of injury, and injury severity. Hyperglycemia was the most common complication and was present in all patients in both the treatment and control groups. The overall infection rate was 64% in the control group compared with 26% in the treatment (P< 0.05). The control group demonstrated a significantly increased rate of respiratory tract infections [45% control vs. 9% treatment (P< 0.05)]. No surgical patients developed a wound infection. One treatment group patient experienced a GI bleed.
Conclusions: This is the largest study evaluating the complications associated with high-dose steroid administration for spinal trauma in a pediatric population. Hyperglycemia was found in all spinal cord injury patients, regardless of steroid treatment. Paradoxically, infection rates were noted to be higher in the control group. GI and wound problems were not significantly different. Larger, multicenter prospective studies are needed to better understand the risks in pediatric SCI patients.
C1 [Cage, Jason M.; Knox, Jeffrey B.] Tripler Army Med Ctr, Orthoped Surg Serv, Honolulu, HI 96859 USA.
[Wimberly, Robert L.; Jo, ChanHee; Riccio, Anthony I.] Texas Scottish Rite Hosp Children, Dept Orthoped, 2222 Welborn St, Dallas, TX 75219 USA.
[Wimberly, Robert L.; Jo, ChanHee; Riccio, Anthony I.] Childrens Med Ctr, Dallas, TX 75235 USA.
[Shaha, Steve] Principal Outcomes Consultant, Ctr Policy & Publ Adm, Draper, UT USA.
RP Riccio, AI (reprint author), Texas Scottish Rite Hosp Children, Dept Orthoped, 2222 Welborn St, Dallas, TX 75219 USA.
EM anthony.riccio@tsrh.org
FU DePuy Synthes
FX Supported by some funding from DePuy Synthes (Investigator Initiated
Grant).
NR 24
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0271-6798
EI 1539-2570
J9 J PEDIATR ORTHOPED
JI J. Pediatr. Orthop.
PD OCT-NOV
PY 2015
VL 35
IS 7
BP 687
EP 692
PG 6
WC Orthopedics; Pediatrics
SC Orthopedics; Pediatrics
GA DD0BW
UT WOS:000369586300016
PM 25494031
ER
PT J
AU Ratziu, V
Harrison, SA
Francque, SM
Bedossa, P
Serfaty, L
Romero-Gomez, M
Cales, P
Abdelmalek, MF
Caldwell, SH
Drenth, J
Anstee, QM
Hum, DW
Hanf, R
Roudot, A
Megnien, S
Staels, B
Sanyal, AJ
AF Ratziu, Vlad
Harrison, Stephen A.
Francque, Sven M.
Bedossa, Pierre
Serfaty, Lawrence
Romero-Gomez, Manuel
Cales, Paul
Abdelmalek, Manal F.
Caldwell, Stephen H.
Drenth, Joost
Anstee, Quentin M.
Hum, Dean W.
Hanf, Remy
Roudot, Alice
Megnien, Sophie
Staels, Bart
Sanyal, Arun J.
TI An international, phase 2 randomized controlled trial of the dual PPAR
alpha-delta agonist GFT505 in adult patients with NASH
SO HEPATOLOGY
LA English
DT Meeting Abstract
CT 66th Annual Meeting of the
American-Association-for-the-Study-of-Liver-Diseases (AASLD)
CY NOV 13-17, 2015
CL San Francisco, CA
SP Amer Assoc Study Liver Dis
C1 [Ratziu, Vlad] Hop La Pitie Salpetriere, Hepatol, Paris, France.
[Harrison, Stephen A.] Brooke Army Med Ctr, Gastroenterol & Hepatol Serv, Dept Med, Ft Sam Houston, TX 78234 USA.
[Francque, Sven M.] Univ Antwerp, Univ Antwerp Hosp, Dept Gastroenterol & Hepatol, B-2020 Antwerp, Belgium.
[Bedossa, Pierre] Univ Paris Denis Diderot, Hop Beaujon, Dept Pathol, Clichy, France.
[Serfaty, Lawrence] UPMC Paris 6, Hop St Antoine, AP HP, Serv Hepatol, Paris, France.
[Romero-Gomez, Manuel] Hosp Univ Valme, Unit Clin Management Digest Dis, Seville, Spain.
[Romero-Gomez, Manuel] CIBERehd, Seville, Spain.
[Cales, Paul] Univ Hosp, Hepatol Dept, Angers, France.
[Cales, Paul] LUNAM Univ, Angers, France.
[Abdelmalek, Manal F.] Duke Univ, Durham, NC USA.
[Caldwell, Stephen H.] Univ Virginia, Gastroenterol & Hepatol Div, Charlottesville, VA USA.
[Drenth, Joost] Radboud Univ Nijmegen, Med Ctr, Dept Gastroenterol & Hepatol, NL-6525 ED Nijmegen, Netherlands.
[Anstee, Quentin M.] Newcastle Univ, Fac Med Sci, Inst Cellular Med, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England.
[Hum, Dean W.; Hanf, Remy; Roudot, Alice; Megnien, Sophie] Genfit SA, Loos, France.
[Staels, Bart] Univ Lille 2, Inst Pasteur Lille, EGID, INSERM,U1011, Lille, France.
[Sanyal, Arun J.] Virginia Commonwealth Univ, Richmond, VA USA.
RI Staels, Bart/N-9497-2016
OI Staels, Bart/0000-0002-3784-1503
NR 0
TC 3
Z9 3
U1 0
U2 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0270-9139
EI 1527-3350
J9 HEPATOLOGY
JI Hepatology
PD OCT
PY 2015
VL 62
SU 1
SI SI
MA 105
BP 262A
EP 263A
PG 2
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA DB2YA
UT WOS:000368375400106
ER
PT J
AU Harrison, SA
Sanyal, AJ
Francque, SM
Bedossa, P
Serfaty, L
Romero-Gomez, M
Cales, P
Abdelmalek, MF
Caldwell, SH
Drenth, J
Anstee, QM
Hum, DW
Hanf, R
Roudot, A
Megnien, S
Staels, B
Ratziu, V
AF Harrison, Stephen A.
Sanyal, Arun J.
Francque, Sven M.
Bedossa, Pierre
Serfaty, Lawrence
Romero-Gomez, Manuel
Cales, Paul
Abdelmalek, Manal F.
Caldwell, Stephen H.
Drenth, Joost
Anstee, Quentin M.
Hum, Dean W.
Hanf, Remy
Roudot, Alice
Megnien, Sophie
Staels, Bart
Ratziu, Vlad
TI Beneficial effects of the dual PPAR alpha-delta agonist, GFT505, on
hepatic and cardiometabolic markers in adult NASH patients.
SO HEPATOLOGY
LA English
DT Meeting Abstract
CT 66th Annual Meeting of the
American-Association-for-the-Study-of-Liver-Diseases (AASLD)
CY NOV 13-17, 2015
CL San Francisco, CA
SP Amer Assoc Study Liver Dis
C1 [Ratziu, Vlad] Hop La Pitie Salpetriere, Hepatol, Paris, France.
[Sanyal, Arun J.] Virginia Commonwealth Univ, Div Gastroenterol Hepatol & Nutr, Internal Med, Richmond, VA USA.
[Harrison, Stephen A.] Brooke Army Med Ctr, Gastroenterol, Ft Worth, TX USA.
[Francque, Sven M.] Antwerp Univ Hosp, Gastroenterol Hepatol, Antwerp, Belgium.
[Bedossa, Pierre] Hop Beaujon, Pathol, Clichy, France.
[Serfaty, Lawrence] Hosp St Antoine, Hepatol Dept, Paris, France.
[Romero-Gomez, Manuel] Valme Univ Hosp, Digest Dis, Seville, Spain.
[Cales, Paul] CHU Angers, Hepatol Dept, Angers, France.
[Abdelmalek, Manal F.] Duke Univ, Med, Durham, NC USA.
[Caldwell, Stephen H.] Univ Virginia, Hepatol Dept, Charlottesville, VA USA.
[Drenth, Joost] RUNMC, Hepatol Dept, Nijmegen, Netherlands.
[Anstee, Quentin M.] Newcastle Univ, Inst Cellular Med, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England.
[Hum, Dean W.; Hanf, Remy; Roudot, Alice; Megnien, Sophie] Genfit, Loos, France.
[Staels, Bart] Univ Lille 2, INSERM, European Genom Inst Diabet, U1011, Lille, France.
RI Staels, Bart/N-9497-2016
OI Staels, Bart/0000-0002-3784-1503
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0270-9139
EI 1527-3350
J9 HEPATOLOGY
JI Hepatology
PD OCT
PY 2015
VL 62
SU 1
SI SI
MA 162
BP 291A
EP 292A
PG 2
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA DB2YA
UT WOS:000368375401047
ER
PT J
AU Sanyal, AJ
Harrison, SA
Francque, SM
Bedossa, P
Serfaty, L
Romero-Gomez, M
Cales, P
Abdelmalek, MF
Caldwell, SH
Drenth, J
Anstee, QM
Hum, DW
Hanf, R
Roudot, A
Megnien, S
Staels, B
Ratziu, V
AF Sanyal, Arun J.
Harrison, Stephen A.
Francque, Sven M.
Bedossa, Pierre
Serfaty, Lawrence
Romero-Gomez, Manuel
Cales, Paul
Abdelmalek, Manal F.
Caldwell, Stephen H.
Drenth, Joost
Anstee, Quentin M.
Hum, Dean W.
Hanf, Remy
Roudot, Alice
Megnien, Sophie
Staels, Bart
Ratziu, Vlad
TI The hepatic and extra-hepatic profile of resolution of steatohepatitis
induced by GFT-505
SO HEPATOLOGY
LA English
DT Meeting Abstract
CT 66th Annual Meeting of the
American-Association-for-the-Study-of-Liver-Diseases (AASLD)
CY NOV 13-17, 2015
CL San Francisco, CA
SP Amer Assoc Study Liver Dis
C1 [Ratziu, Vlad] Hop La Pitie Salpetriere, Hepatol, Paris, France.
[Sanyal, Arun J.] Virginia Commonwealth Univ, Div Gastroenterol Hepatol & Nutr, Internal Med, Richmond, VA USA.
[Harrison, Stephen A.] Brooke Army Med Ctr, Gastroenterol, Ft Sam Houston, TX 78234 USA.
[Francque, Sven M.] Univ Antwerp Hosp, Gastroenterol Hepatol, Antwerp, Belgium.
[Bedossa, Pierre] Hop Beaujon, Pathol, Clichy, France.
[Serfaty, Lawrence] Hop St Antoine, Hepatol Dept, F-75571 Paris, France.
[Romero-Gomez, Manuel] Valme Univ Hosp, Digest Dis, Seville, Spain.
[Cales, Paul] Univ Hosp, Hepatol Dept, Angers, France.
[Cales, Paul] LUNAM Univ, Angers, France.
[Abdelmalek, Manal F.] Duke Univ, Med, Durham, NC USA.
[Caldwell, Stephen H.] Univ Virginia, Hepatol Dept, Charlottesville, VA USA.
[Drenth, Joost] RUNMC, Dept Gastroenterol & Hepatol, Nijmegen, Netherlands.
[Anstee, Quentin M.] Newcastle Univ, Inst Cellular Med, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England.
[Hum, Dean W.; Hanf, Remy; Roudot, Alice; Megnien, Sophie] Genfit SA, Loos, France.
[Staels, Bart] Inst Pasteur, EGID, INSERM, U1011, Lille, France.
RI Staels, Bart/N-9497-2016
OI Staels, Bart/0000-0002-3784-1503
NR 0
TC 3
Z9 3
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0270-9139
EI 1527-3350
J9 HEPATOLOGY
JI Hepatology
PD OCT
PY 2015
VL 62
SU 1
SI SI
MA 2145
BP 1252A
EP 1252A
PG 1
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA DB2YA
UT WOS:000368375404387
ER
PT J
AU Gjuka, D
Song, XL
Yoo, W
Yoo, SY
Wang, J
Fallon, MB
Ioannou, GN
Harrison, SA
Beretta, L
AF Gjuka, Donjeta
Song, Xiaoling
Yoo, Wonbeak
Yoo, Suk Young
Wang, Jing
Fallon, Michael B.
Ioannou, George N.
Harrison, Stephen A.
Beretta, Laura
TI Non-invasive Diagnosis of Non-alcoholic Steatohepatitis (NASH) using a
Panel of Fatty Acids
SO HEPATOLOGY
LA English
DT Meeting Abstract
CT 66th Annual Meeting of the
American-Association-for-the-Study-of-Liver-Diseases (AASLD)
CY NOV 13-17, 2015
CL San Francisco, CA
SP Amer Assoc Study Liver Dis
C1 [Gjuka, Donjeta; Yoo, Wonbeak; Beretta, Laura] Univ Texas MD Anderson Canc Ctr, Mol & Cellular Oncol, Houston, TX 77030 USA.
[Song, Xiaoling] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA.
[Yoo, Suk Young; Wang, Jing] Univ Texas MD Anderson Canc Ctr, Bioinformat & Computat Biol, Houston, TX 77030 USA.
[Fallon, Michael B.] Univ Texas MD Anderson Canc Ctr, Div Gastroenterol, Houston, TX 77030 USA.
[Ioannou, George N.] Vet Affairs Puget Sound Hlth Care Syst, Div Gastroenterol, Seattle, WA USA.
[Ioannou, George N.] Univ Washington, Seattle, WA 98195 USA.
[Harrison, Stephen A.] Brooke Army Med Ctr, Dept Med, Houston, TX USA.
NR 0
TC 0
Z9 0
U1 1
U2 3
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0270-9139
EI 1527-3350
J9 HEPATOLOGY
JI Hepatology
PD OCT
PY 2015
VL 62
SU 1
SI SI
MA 2151
BP 1255A
EP 1256A
PG 2
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA DB2YA
UT WOS:000368375404393
ER
PT J
AU Beaulieu, JJ
Nietch, CT
Young, JL
AF Beaulieu, Jake J.
Nietch, Christopher T.
Young, Jade L.
TI Controls on nitrous oxide production and consumption in reservoirs of
the Ohio River Basin
SO JOURNAL OF GEOPHYSICAL RESEARCH-BIOGEOSCIENCES
LA English
DT Article
DE nitrous oxide; nitrification; denitrification; stratification; mixing;
turnover
ID FRESH-WATER LAKES; NITRATE REDUCTION; HEADWATER STREAMS; METHANE
EMISSIONS; TEMPERATE LAKE; N2O EMISSIONS; DENITRIFICATION; DINITROGEN;
OXYGEN; ACCUMULATION
AB Aquatic ecosystems are a globally significant source of nitrous oxide (N2O), a potent greenhouse gas, but estimates are largely based on studies conducted in streams and rivers with relatively less known about N2O dynamics in reservoirs. Due to long water residence times and high nitrogen (N) loading rates, reservoirs support substantial N processing and therefore may be particularly important sites of N2O production. Predicting N2O emissions from reservoirs is difficult due to complex interactions between microbial N processing in the oxygen-poor hypolimnion and oxygen-rich epilimnion. Here we present the results of a survey of N2O depth profiles in 20 reservoirs draining a broad range of land use conditions in four states in the U.S. Nitrous oxide was supersaturated in the epilimnion of 80% of the reservoirs and was undersaturated in only one, indicating that reservoirs in this region are generally a source of N2O to the atmosphere. Nitrous oxide was undersaturated in the hypolimnion of 10 reservoirs, supersaturated in 9, and transitioned from supersaturation to undersaturation in 1 reservoir that was monitored periodically from midsummer to fall. All reservoirs with a mean hypolimnion nitrate concentration less than 50 mu gNL(-1) showed evidence of net N2O consumption in the hypolimnion. All reservoirs sampled during lake turnover supported N2O production throughout the water column. These results indicate that N2O dynamics in reservoirs differ widely both among systems and through time but can be predicted based on N and oxygen availability and degree of thermal stratification.
C1 [Beaulieu, Jake J.; Nietch, Christopher T.] US EPA, Off Res & Dev, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
[Young, Jade L.] US Army, Corps Engineers, Louisville Dist Water Qual, Louisville, KY USA.
RP Beaulieu, JJ (reprint author), US EPA, Off Res & Dev, Natl Risk Management Res Lab, Cincinnati, OH 45268 USA.
EM beaulieu.jake@epa.gov
FU U.S. Environmental Protection Agency through its Office of Research and
Development
FX We thank Kenvirons Inc. for field support. The U.S. Environmental
Protection Agency, through its Office of Research and Development,
partially funded and collaborated in the research described herein. It
has been subjected to the Agency's administrative review and has been
approved for external publication. Any opinions expressed in this paper
are those of the author(s) and do not necessarily reflect the views of
the U.S. Environmental Protection Agency or the U.S. Army Corps of
Engineers; therefore, no official endorsement should be inferred. Any
mention of trade names or commercial products does not constitute
endorsement or recommendation for use. The data used to produce the
results of this paper can be obtained at no charge from the
corresponding author.
NR 59
TC 5
Z9 5
U1 14
U2 32
PU AMER GEOPHYSICAL UNION
PI WASHINGTON
PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA
SN 2169-8953
EI 2169-8961
J9 J GEOPHYS RES-BIOGEO
JI J. Geophys. Res.-Biogeosci.
PD OCT
PY 2015
VL 120
IS 10
BP 1995
EP 2010
DI 10.1002/2015JG002941
PG 16
WC Environmental Sciences; Geosciences, Multidisciplinary
SC Environmental Sciences & Ecology; Geology
GA DB7XK
UT WOS:000368730300008
ER
PT J
AU Thompson, MG
Truong-Le, V
Alamneh, YA
Black, CC
Anderl, J
Honnold, CL
Pavlicek, RL
Abu-Taleb, R
Wise, MC
Hall, ER
Wagar, EJ
Patzer, E
Zurawski, DV
AF Thompson, Mitchell G.
Truong-Le, Vu
Alamneh, Yonas A.
Black, Chad C.
Anderl, Jeff
Honnold, Cary L.
Pavlicek, Rebecca L.
Abu-Taleb, Rania
Wise, Matthew C.
Hall, Eric R.
Wagar, Eric J.
Patzer, Eric
Zurawski, Daniel V.
TI Evaluation of Gallium Citrate Formulations against a Multidrug-Resistant
Strain of Klebsiella pneumoniae in a Murine Wound Model of Infection
SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
LA English
DT Article
ID SIDEROPHORE MONOSULFACTAM BAL30072; BLOOD-STREAM INFECTIONS;
METALLO-BETA-LACTAMASE; IRON UPTAKE SYSTEM; ACINETOBACTER-BAUMANNII;
PSEUDOMONAS-AERUGINOSA; ESCHERICHIA-COLI; IN-VITRO; ANTIMICROBIAL
ACTIVITIES; MYCOBACTERIUM-AVIUM
AB Skin and soft tissue infections (SSTIs) are a common occurrence in health care facilities with a heightened risk for immuno-compromised patients. Klebsiella pneumoniae has been increasingly implicated as the bacterial agent responsible for SSTIs, and treatment can be challenging as more strains become multidrug resistant (MDR). Therefore, new treatments are needed to counter this bacterial pathogen. Gallium complexes exhibit antimicrobial activity and are currently being evaluated as potential treatment for bacterial infections. In this study, we tested a topical formulation containing gallium citrate (GaCi) for the treatment of wounds infected with K. pneumoniae. First, the MIC against K. pneumoniae ranged from 0.125 to 2.0 mu g/ml GaCi. After this in vitro efficacy was established, two topical formulations with GaCi (0.1% [wt/vol] and 0.3% [wt/vol]) were tested in a murine wound model of MDR K. pneumoniae infection. Gross pathology and histopathology revealed K. pneumoniae-infected wounds appeared to close faster with GaCi treatment and were accompanied by reduced inflammation compared to those of untreated controls. Similarly, quantitative indications of infection remediation, such as reduced weight loss and wound area, suggested that treatment improved outcomes compared to those of untreated controls. Bacterial burdens were measured 1 and 3 days following inoculation, and a 0.5 to 1.5 log reduction of CFU was observed. Lastly, upon scanning electron microscopy analysis, GaCi treatment appeared to prevent biofilm formation on dressings compared to those of untreated controls. These results suggest that with more preclinical testing, a topical application of GaCi may be a promising alternative treatment strategy for K. pneumoniae SSTI.
C1 [Thompson, Mitchell G.; Alamneh, Yonas A.; Black, Chad C.; Abu-Taleb, Rania; Wagar, Eric J.; Zurawski, Daniel V.] Walter Reed Army Inst Res, Dept Wound Infect, Silver Spring, MD 20910 USA.
[Truong-Le, Vu; Anderl, Jeff; Patzer, Eric] Aridis Pharmaceut LLC, San Jose, CA USA.
[Honnold, Cary L.; Wise, Matthew C.] Walter Reed Army Inst Res, Dept Pathol, Silver Spring, MD USA.
[Pavlicek, Rebecca L.; Hall, Eric R.] Naval Med Res Ctr, Dept Wound Infect, Silver Spring, MD USA.
RP Zurawski, DV (reprint author), Walter Reed Army Inst Res, Dept Wound Infect, Silver Spring, MD 20910 USA.
EM daniel.v.zurawski.ctr@mail.mil
OI Zurawski, Daniel/0000-0002-7920-5601
FU Defense Medical Research and Development Program [DM090034]
FX Specifically, we acknowledge the Defense Medical Research and
Development Program award no. DM090034, which provided the funding for
this work.
NR 67
TC 2
Z9 3
U1 0
U2 1
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0066-4804
EI 1098-6596
J9 ANTIMICROB AGENTS CH
JI Antimicrob. Agents Chemother.
PD OCT
PY 2015
VL 59
IS 10
BP 6484
EP 6493
DI 10.1128/AAC.00882-15
PG 10
WC Microbiology; Pharmacology & Pharmacy
SC Microbiology; Pharmacology & Pharmacy
GA DA1YJ
UT WOS:000367591800074
PM 26239978
ER
PT J
AU Piper, LC
Zogg, CK
Schneider, EB
Orman, JA
Rasmussen, TE
Blackbourne, LH
Haider, AH
AF Piper, Lydia C.
Zogg, Cheryl K.
Schneider, Eric B.
Orman, Jean A.
Rasmussen, Todd E.
Blackbourne, Lorne H.
Haider, Adil H.
TI Guidelines for the Treatment of Severe Traumatic Brain Injury: Are They
Used?
SO JAMA SURGERY
LA English
DT Letter
ID PRESSURE; TRIAL
C1 [Piper, Lydia C.; Schneider, Eric B.] Johns Hopkins Univ, Sch Med, Dept Surg, Baltimore, MD 21205 USA.
[Zogg, Cheryl K.; Haider, Adil H.] Harvard Univ, Sch Med, Harvard Sch Publ Hlth, Ctr Surg & Publ Hlth, Boston, MA USA.
[Zogg, Cheryl K.; Haider, Adil H.] Brigham & Womens Hosp, Dept Surg, Boston, MA 02120 USA.
[Orman, Jean A.] Uniformed Serv Univ Hlth Sci, Dept Med, Washington, DC USA.
[Rasmussen, Todd E.] Univ Maryland, Sch Med, Dept Surg, Baltimore, MD 21201 USA.
[Blackbourne, Lorne H.] Brooke Army Med Ctr, Dept Surg, San Antonio, TX USA.
RP Haider, AH (reprint author), Brigham & Womens Hosp, Dept Surg, 1620 Tremont St,One Brigham Circle,Ste 4-020, Boston, MA 02120 USA.
EM ahhaider@partners.org
NR 6
TC 1
Z9 1
U1 0
U2 1
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 2168-6254
EI 2168-6262
J9 JAMA SURG
JI JAMA Surg.
PD OCT
PY 2015
VL 150
IS 10
BP 1013
EP 1015
DI 10.1001/jamasurg.2015.1838
PG 3
WC Surgery
SC Surgery
GA DA1WB
UT WOS:000367585200022
PM 26267138
ER
PT J
AU Mikulski, D
Hudas, G
Das, S
Lewis, F
AF Mikulski, Dariusz
Hudas, Greg
Das, Sajal
Lewis, Frank
TI Special Issue: Modeling & Simulation for Cyber Security of Autonomous
Vehicle Systems
SO JOURNAL OF DEFENSE MODELING AND SIMULATION-APPLICATIONS METHODOLOGY
TECHNOLOGY-JDMS
LA English
DT Editorial Material
C1 [Mikulski, Dariusz; Hudas, Greg] US Army Tank Automot Res Dev & Engn Ctr, Warren, MI USA.
[Das, Sajal] Missouri Univ Sci & Technol, Dept Comp Sci, Rolla, MO USA.
[Lewis, Frank] Univ Texas Arlington, Automat & Robot Res Inst, Arlington, TX 76019 USA.
RP Lewis, F (reprint author), Univ Texas Arlington, Automat & Robot Res Inst, Arlington, TX 76019 USA.
EM lewis@uta.edu
NR 0
TC 0
Z9 0
U1 2
U2 4
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1548-5129
EI 1557-380X
J9 J DEF MODEL SIMUL-AP
JI J. Def. Model. Simul.-Appl. Methodol. Technol.-JDMS
PD OCT
PY 2015
VL 12
IS 4
SI SI
BP 359
EP 361
DI 10.1177/1548512915604584
PG 3
WC Engineering, Multidisciplinary
SC Engineering
GA DA1JC
UT WOS:000367551100001
ER
PT J
AU Yoginath, SB
Perumalla, KS
Henz, BJ
AF Yoginath, Srikanth B.
Perumalla, Kalyan S.
Henz, Brian J.
TI Virtual machine-based simulation platform for mobile ad-hoc
network-based cyber infrastructure
SO JOURNAL OF DEFENSE MODELING AND SIMULATION-APPLICATIONS METHODOLOGY
TECHNOLOGY-JDMS
LA English
DT Article
DE Network simulation; discrete event simulation; virtual machine;
hypervisor; ad-hoc networks; virtual time; real time; scheduling;
synchronization
AB In modeling and simulating complex systems, such as mobile ad-hoc networks (MANETs), in defense communications, it is a major challenge to reconcile multiple important considerations: the rapidity of unavoidable changes to the software (network layers and applications), the difficulty of modeling the critical, implementation-dependent behavioral effects, the need to sustain larger scale scenarios, and the desire for faster simulations. Here we present our approach in successfully reconciling them using a virtual time-synchronized virtual machine (VM)-based parallel execution framework that accurately lifts both the devices, as well as the network communications, to a virtual time plane while retaining full fidelity. At the core of our framework is a scheduling engine that operates at the level of a hypervisor scheduler, offering a unique ability to execute multi-core guest nodes over multi-core host nodes in an accurate, virtual time-synchronized manner. In contrast to other related approaches that suffer from either speed or accuracy issues, our framework provides MANET node-wise scalability, high fidelity of software behaviors, and time-ordering accuracy. The design and development of this framework is presented, and an actual implementation based on the widely used Xen hypervisor system is described. Benchmarks with synthetic and actual applications are used to identify the benefits of our approach. The time inaccuracy of traditional emulation methods is demonstrated, in comparison with the accurate execution of our framework verified by theoretically correct results expected from analytical models of the same scenarios. In the largest high-fidelity tests, we are able to perform virtual time-synchronized simulation of 64-node VM-based full-stack, actual software behaviors of MANETs containing a mix of static and mobile (unmanned airborne vehicle) nodes, hosted on a 32-core host, with full fidelity of unmodified ad-hoc routing protocols, unmodified application executables, and user-controllable physical layer effects, including inter-device wireless signal strength, reachability, and connectivity.
C1 [Yoginath, Srikanth B.] Oak Ridge Natl Lab, Computat Sci & Engn Div, Oak Ridge, TN 37831 USA.
[Perumalla, Kalyan S.; Henz, Brian J.] US Army Res Lab, Computat & Informat Sci Directorate, Washington, DC USA.
RP Perumalla, KS (reprint author), Oak Ridge Natl Lab, Computat Sci & Engn Div, Oak Ridge, TN 37831 USA.
EM perumallaks@ornl.gov
OI Perumalla, Kalyan/0000-0002-7458-0832
NR 31
TC 0
Z9 0
U1 0
U2 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1548-5129
EI 1557-380X
J9 J DEF MODEL SIMUL-AP
JI J. Def. Model. Simul.-Appl. Methodol. Technol.-JDMS
PD OCT
PY 2015
VL 12
IS 4
SI SI
BP 439
EP 456
DI 10.1177/1548512915591050
PG 18
WC Engineering, Multidisciplinary
SC Engineering
GA DA1JC
UT WOS:000367551100008
ER
PT J
AU Liu, XX
Yu, T
Dobson, NR
McEntire, BL
Ward, RM
Spigarelli, MG
Hunt, CE
Sherwin, CMT
AF Liu, Xiaoxi
Yu, Tian
Dobson, Nicole R.
McEntire, Betty L.
Ward, Robert M.
Spigarelli, Michael G.
Hunt, Carl E.
Sherwin, Catherine M. T.
TI Pharmacokinetic Modeling of Plasma and Salivary Caffeine Circulation in
Infants Receiving Extended Caffeine Therapy for Intermittent Hypoxia
Treatment
SO JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS
LA English
DT Meeting Abstract
C1 [Liu, Xiaoxi; Yu, Tian; Ward, Robert M.; Spigarelli, Michael G.; Sherwin, Catherine M. T.] Univ Utah, Sch Med, Dept Pediat, Salt Lake City, UT USA.
[Dobson, Nicole R.] Tripler Army Med Ctr, Pediat, Honolulu, HI 96859 USA.
[McEntire, Betty L.] Amer SIDS Inst, Naples, FL USA.
[Hunt, Carl E.] Uniformed Serv Univ Hlth Sci, Pediat, Bethesda, MD 20814 USA.
RI Yu, Tian/L-9383-2016
OI Yu, Tian/0000-0002-4044-7902
NR 0
TC 0
Z9 0
U1 2
U2 2
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1567-567X
EI 1573-8744
J9 J PHARMACOKINET PHAR
JI J. Pharmacokinet. Pharmacodyn.
PD OCT
PY 2015
VL 42
SU 1
MA W-47
BP S95
EP S96
PG 2
WC Pharmacology & Pharmacy
SC Pharmacology & Pharmacy
GA DA5KM
UT WOS:000367842000186
ER
PT J
AU Bodo, M
Simovic, M
Pearce, F
Ahmed, A
Armonda, R
AF Bodo, M.
Simovic, M.
Pearce, F.
Ahmed, A.
Armonda, R.
TI Correlation of rheoencephalogram and intracranial pressure: results of a
rat study
SO PHYSIOLOGICAL MEASUREMENT
LA English
DT Article
DE cerebrovascular reactivity; ICP; REG; rat; time constant
ID ETHYL APOVINCAMINATE; ANESTHETIZED DOGS; BLOOD-FLOW; AUTOREGULATION;
CIRCULATION; VINPOCETINE; REACTIVITY; INJURY; BRAIN
AB Measuring brain electrical impedance (rheoencephalography-REG) is a potential technique for noninvasive, continuous neuro-monitoring. Typically, intracranial pressure (ICP), an invasive monitoring modality, is used in brain monitoring. Our hypothesis was that both modalities would reflect cerebrovascular reactivity. In the present study we compared results of REG to results of ICP measurement. Rats were used under anesthesia (n = 12; 36 control and 59 vinpocetine infusions). REG was measured by two bipolar REG amplifiers; time constants (Tc) were 3 and 0.3 s. The vinpocetine injection caused a transient decrease in systemic arterial pressure (SAP) and a simultaneous increase in ICP and REG pulse amplitude. SAP decrease was 25% +/- 14%; ICP was 28% +/- 16%; REG pulse amplitude increase was 209% +/- 17% (Tc 3) and 107% +/- 68% (Tc 0.3). ICP increase correlated with REG pulse amplitude increase. Area under the receiver operating characteristic curve was 0.9481 for ICP-REG time constants 3 and 0.9335 for ICP-REG time constants 0.3; both with p < 0.0001. The fact that both REG and ICP reflect cerebrovascular reactivity indicates the usefulness of REG as a potential technique for noninvasive, continuous neuro-monitoring. The Tc of REG amplifier requires optimization for continuous monitoring of pressure reactivity index.
C1 [Bodo, M.; Simovic, M.; Pearce, F.; Ahmed, A.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA.
[Bodo, M.; Armonda, R.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
RP Bodo, M (reprint author), Walter Reed Army Inst Res, Silver Spring, MD 20910 USA.
EM mikebodo@comcast.net
FU U.S. Army Medical Research and Materiel Command through WRAIR [CCCRP:
D43_001_2008 WRAIR]
FX The views expressed in this article are those of the author and do not
necessarily reflect the official policy or position of the Department of
the Navy, Department of Defense, nor the US Government. This study
protocol was reviewed and approved by the Walter Reed Army Institute of
Research/Naval Medical Research Center Institutional Animal Care and Use
Committee in compliance with all applicable Federal regulations
governing the protection of animals in research. We are military members
or employees of the US Government. This work was prepared as part of
official duties; Title 17 USC 105 provides that Copyright protection is
not available for any work of the US Government. This work was supported
by the U.S. Army Medical Research and Materiel Command through WRAIR
(CCCRP: D43_001_2008 WRAIR).
NR 34
TC 0
Z9 0
U1 1
U2 7
PU IOP PUBLISHING LTD
PI BRISTOL
PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
SN 0967-3334
EI 1361-6579
J9 PHYSIOL MEAS
JI Physiol. Meas.
PD OCT
PY 2015
VL 36
IS 10
DI 10.1088/0967-3334/36/10/N115
PG 12
WC Biophysics; Engineering, Biomedical; Physiology
SC Biophysics; Engineering; Physiology
GA DA3IN
UT WOS:000367690500001
PM 26334594
ER
PT J
AU Cheychom, J
Kanchanakhan, N
Vijaykadga, S
Gaywee, J
Harnyuttanakorn, P
AF Cheychom, Jitravee
Kanchanakhan, Naowarat
Vijaykadga, Saowanit
Gaywee, Jariyanart
Harnyuttanakorn, Pongchai
TI Cytochrome b mutation and atovaquone susceptibility in Plasmodium
falciparum isolates from the Thai-Cambodian border during 1990-2010
SO SCIENCEASIA
LA English
DT Article
DE malaria; in vitro drug sensitivity assay
ID POLYMERASE CHAIN-REACTION; IN-VITRO; RESISTANCE; MALARIA; PROGUANIL;
PARASITE; AFRICA; TRAVELER; DRUG; VIVO
AB WHO reported that the efficacy of artemisinin combination-based therapies (ACTs) has decreased around the Thai-Cambodian border. To maintain the efficacy and prolong the life span of ACTs, malarone (an atovaquone and proguanil combination) has been administered in Trat and Chanthaburi Provinces of Thailand since 2009. The mutations of codons 133, 258, 268, 272, 275, 280, 283, and 284 in the cytochrome b gene have been reported to be related to malarone resistance. This study investigates the susceptibility in vitro and mutations in the cytochrome b gene before and after the administration of malarone. Plasmodium falciparum infected blood samples obtained from malaria patients attending malaria clinics in these two provinces were included in this study. Fifteen parasite isolates were subjected to in vitro susceptibility tests against atovaquone. Their mean inhibitory concentrations ranged from 5 x 10(-9)-5 x 10(-10) M. The DNA sequences from 37 PCR samples revealed no mutations. Therefore the variation of drug susceptibility among these parasites may be unrelated to point mutations in the cytochrome b gene.
C1 [Cheychom, Jitravee; Kanchanakhan, Naowarat] Chulalongkorn Univ, Coll Publ Hlth Sci, Bangkok 10330, Thailand.
[Vijaykadga, Saowanit] Minist Publ Hlth, Dept Dis Control, Bur Vector Borne Dis, Nonthaburi 11000, Thailand.
[Gaywee, Jariyanart] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand.
[Harnyuttanakorn, Pongchai] Chulalongkorn Univ, Fac Sci, Dept Biol, Bangkok 10330, Thailand.
RP Harnyuttanakorn, P (reprint author), Chulalongkorn Univ, Fac Sci, Dept Biol, Bangkok 10330, Thailand.
EM Pongchai.H@chula.ac.th
FU Strategic Scholarships Fellowships Frontier Research Networks from the
Commission on Higher Education, Thailand; 90th Anniversary of
Chulalongkorn University Fund (Ratchadaphiseksomphot Endowment Fund)
FX We thank the College of Public Health Sciences and the Faculty of
Science, Chulalongkorn University. We would like to thank Strategic
Scholarships Fellowships Frontier Research Networks (specific for
Southern region) for the Ph.D. Programme Thai doctoral degree from the
Commission on Higher Education, Thailand for its financial support, and
the 90th Anniversary of Chulalongkorn University Fund
(Ratchadaphiseksomphot Endowment Fund).
NR 28
TC 0
Z9 0
U1 1
U2 2
PU THAILANDS NATL SCIENCE & TECHNOLOGY DEVELOPMENT AGENCY
PI BANGKOK
PA PUBLIC INFORMATION DEPT, 73/1 RAMA VI RD, RAJDHEVEE, BANGKOK, 00000,
THAILAND
SN 1513-1874
J9 SCIENCEASIA
JI Scienceasia
PD OCT
PY 2015
VL 41
IS 5
BP 340
EP 344
DI 10.2306/scienceasia1513-1874.2015.41.340
PG 5
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CZ7LU
UT WOS:000367281700007
ER
PT J
AU Boyer, N
Hunninghake, J
Womble, S
AF Boyer, Nathan
Hunninghake, John
Womble, Shannon
TI Implementation of a Rapid Response System: Evaluating the Effect on
Rapid Response Activation and Code Rates
SO CHEST
LA English
DT Meeting Abstract
C1 [Boyer, Nathan; Hunninghake, John; Womble, Shannon] Brooke Army Med Ctr, San Antonio, TX USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER COLL CHEST PHYSICIANS
PI GLENVIEW
PA 2595 PATRIOT BLVD, GLENVIEW, IL 60026 USA
SN 0012-3692
J9 CHEST
JI Chest
PD OCT
PY 2015
VL 148
IS 4
SU S
MA 471A
DI 10.1378/chest.2270030
PG 2
WC Critical Care Medicine; Respiratory System
SC General & Internal Medicine; Respiratory System
GA CY0ZB
UT WOS:000366134400461
ER
PT J
AU Goss, A
Sherratt, J
AF Goss, Amanda
Sherratt, Jesse
TI Metastatic Medullary Renal Cell Carcinoma Diagnosed by Endobronchial
Ultrasound Guided Transbronchial Needle Aspiration
SO CHEST
LA English
DT Meeting Abstract
C1 [Goss, Amanda; Sherratt, Jesse] Tripler Army Med Ctr, Kaneohe, HI USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU AMER COLL CHEST PHYSICIANS
PI GLENVIEW
PA 2595 PATRIOT BLVD, GLENVIEW, IL 60026 USA
SN 0012-3692
J9 CHEST
JI Chest
PD OCT
PY 2015
VL 148
IS 4
SU S
MA 845A
DI 10.1378/chest.2254075
PG 2
WC Critical Care Medicine; Respiratory System
SC General & Internal Medicine; Respiratory System
GA CZ5SU
UT WOS:000367163100297
ER
PT J
AU Mullins, KE
Hang, J
Jiang, J
Leguia, M
Kasper, MR
Ventosilla, P
Maguina, C
Jarman, RG
Blazes, D
Richards, AL
AF Mullins, Kristin E.
Hang, Jun
Jiang, Ju
Leguia, Mariana
Kasper, Matthew R.
Ventosilla, Palmira
Maguina, Ciro
Jarman, Richard G.
Blazes, David
Richards, Allen L.
TI Description of Bartonella ancashensis sp nov., isolated from the blood
of two patients with verruga peruana
SO INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY
LA English
DT Article
ID COMB-NOV; HENSELAE; IDENTIFICATION; BACILLIFORMIS; PROPOSALS; UNIFY
AB Three novel isolates of the genus Bartonella were recovered from the blood of two patients enrolled in a clinical trial for the treatment of chronic stage Bartonella bacilliformis infection (verruga peruana) in Caraz, Ancash, Peru. The isolates were initially characterized by sequencing a fragment of the gltA gene, and found to be disparate from B. bacilliformis. The isolates were further characterized using phenotypic and genotypic methods, and found to be genetically identical to each other for the genes assessed, but distinct from any known species of the genus Bartonella, including the closest relative B. bacilliformis. Other characteristics of the isolates, including their morphology, microscopic and biochemical properties, and growth patterns, were consistent with members of the genus Bartonella. Based on these results, we conclude that these three isolates are members of a novel species of the genus Bartonella for which we propose the name Bartonella ancashensis sp. nov. (type strain 20.00(T)=ATCC BAA-2694(T)=DSM 29364(T)).
C1 [Mullins, Kristin E.; Blazes, David; Richards, Allen L.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
[Mullins, Kristin E.; Jiang, Ju; Richards, Allen L.] US Navy, Med Res Ctr, Silver Spring, MD 20910 USA.
[Hang, Jun; Jarman, Richard G.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA.
[Leguia, Mariana; Kasper, Matthew R.] US Navy, Med Res Unit 6, Lima, Peru.
[Ventosilla, Palmira; Maguina, Ciro] Alexander von Humboldt Univ Reruana Cayetano Here, Inst Trop Med, Lima, Peru.
RP Mullins, KE (reprint author), Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
EM kristin.e.mullins3.ctr@mail.mil
OI Ventosilla, Palmira/0000-0002-1035-8386
NR 18
TC 4
Z9 4
U1 0
U2 0
PU SOC GENERAL MICROBIOLOGY
PI READING
PA MARLBOROUGH HOUSE, BASINGSTOKE RD, SPENCERS WOODS, READING RG7 1AG,
BERKS, ENGLAND
SN 1466-5026
EI 1466-5034
J9 INT J SYST EVOL MICR
JI Int. J. Syst. Evol. Microbiol.
PD OCT
PY 2015
VL 65
BP 3339
EP 3343
DI 10.1099/ijsem.0.000416
PN 10
PG 5
WC Microbiology
SC Microbiology
GA CY1FM
UT WOS:000366152100017
PM 26296673
ER
PT J
AU Bookstaver, DA
Bland, CM
Arroyo, MA
AF Bookstaver, David A.
Bland, Christopher M.
Arroyo, Miguel A.
TI Evaluation of cefazolin as a surrogate marker for cefpodoxime
susceptibility for urinary tract isolates
SO JOURNAL OF MEDICAL MICROBIOLOGY
LA English
DT Article
ID ACUTE UNCOMPLICATED CYSTITIS; ESCHERICHIA-COLI;
TRIMETHOPRIM-SULFAMETHOXAZOLE; RESISTANCE; WOMEN
AB Of the cephalosporins, cefpodoxime has the most published clinical data for the treatment of urinary tract infections. In 2014, the Clinical and Laboratory Standards Institute (CLSI) guidelines recommended that cefazolin should be used as the surrogate marker for cefpodoxime among urinary tract isolates, replacing cephalothin. This study attempted to determine how well cefazolin serves as the surrogate marker. Additionally, it investigated how cefuroxime compared with cefazolin as a surrogate marker. The Micro Scan Walkaway Plus system was used to determine susceptibility for cefazolin and cefuroxime on consecutive urine cultures with a colony count of >= 50 000 organisms. Only Escherichia coli, Klebsiella pneumoniae and Proteus mirabilis isolates were included, following CLSI guidelines. Simultaneously, an Etest for cefpodoxime was conducted. The cefpodoxime interpretation was compared with that of the other two agents, and the categorical agreement was calculated, defined as the percentage of identical susceptibility interpretations. Cefazolin (92 %) had a significantly higher categorical agreement than cefuroxime (85 %) among 284 isolates (P=0.011). The major error rate was 4.4 % for cefazolin and 1.1 % for cefuroxime. The very major error rate was 64 % for cefazolin and 18 % for cefuroxime among the 11 cefpodoxime-resistant isolates. Cefazolin was a better predictor of cefpodoxime susceptibility than the previously recommended agent, cephalothin. However, cefuroxime had better major and very major error rates than cefazolin.
C1 [Bookstaver, David A.; Bland, Christopher M.] Eisenhower Army Med Ctr, Dept Pharm, Ft Gordon, GA 30905 USA.
[Arroyo, Miguel A.] Eisenhower Army Med Ctr, Dept Pathol, Ft Gordon, GA 30905 USA.
RP Bookstaver, DA (reprint author), Eisenhower Army Med Ctr, Dept Pharm, 300 Hosp Rd, Ft Gordon, GA 30905 USA.
EM david.a.bookstaver.civ@mail.mil
OI Arroyo, Miguel/0000-0001-7416-8867
NR 11
TC 1
Z9 1
U1 0
U2 1
PU SOC GENERAL MICROBIOLOGY
PI READING
PA MARLBOROUGH HOUSE, BASINGSTOKE RD, SPENCERS WOODS, READING RG7 1AG,
BERKS, ENGLAND
SN 0022-2615
EI 1473-5644
J9 J MED MICROBIOL
JI J. Med. Microbiol.
PD OCT
PY 2015
VL 64
BP 1170
EP 1173
DI 10.1099/jmm.0.000142
PN 10
PG 4
WC Microbiology
SC Microbiology
GA CX1MS
UT WOS:000365460900008
PM 26219948
ER
PT J
AU Doll, TAPF
Neef, T
Duong, N
Lanar, DE
Ringler, P
Muller, SA
Burkhard, P
AF Doll, Tais A. P. F.
Neef, Tobias
Nha Duong
Lanar, David E.
Ringler, Philippe
Mueller, Shirley A.
Burkhard, Peter
TI Optimizing the design of protein nanoparticles as carriers for vaccine
applications
SO NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
LA English
DT Article
DE Protein nanoparticle; Malaria; Vaccine carrier; Protein design;
Self-assembly
ID TRANSMISSION ELECTRON-MICROSCOPY; ASSEMBLIES; LINKERS; CHEMISTRY;
RESPONSES; PLATFORM; MALARIA; DISPLAY; ANTIGEN; SYSTEMS
AB Successful vaccine development remains a huge challenge for infectious diseases such as malaria, HIV and influenza. As a novel way to present antigenic epitopes to the immune system, we have developed icosahedral self-assembling protein nanoparticles (SAPNs) to serve as a prototypical vaccine platform for infectious diseases. Here we examine some biophysical factors that affect the self-assembly of these nanoparticles, which have as basic building blocks coiled-coil oligomerization domains joined by a short linker region. Relying on in silico computer modeling predictions, we selected five different linker regions from the RCSB protein database that connect oligomerization domains, and then further studied the self-assembly and stability of in vitro produced nanoparticles through biophysical characterization of formed particles. One design in particular, T2i88, revealed excellent self-assembly and homogeneity thus paving the way toward a more optimized nanoparticle for vaccine applications.
From the Clinical Editor: Despite the widespread use of vaccines worldwide, successful development of vaccines against some diseases remains a challenge still. In this article, the authors investigated the physic-chemical and biological properties of icosahedral self-assembling protein nanoparticles (SAPNs), which mimic viral particles, in order to utilize this technology as potential platform for future design of vaccines. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Doll, Tais A. P. F.; Burkhard, Peter] Univ Connecticut, Inst Mat Sci, Storrs, CT 06269 USA.
[Neef, Tobias; Nha Duong; Burkhard, Peter] Univ Connecticut, Dept Mol & Cell Biol, Storrs, CT USA.
[Lanar, David E.] Walter Reed Army Inst Res, Malaria Vaccine Branch, Silver Spring, MD USA.
[Ringler, Philippe; Mueller, Shirley A.] Univ Basel, Biozentrum, C CINA, Basel, Switzerland.
RP Burkhard, P (reprint author), Univ Connecticut, Inst Mat Sci, Storrs, CT 06269 USA.
EM peter.burkhard@uconn.edu
FU NIH/NIGMS [1P01GM096971]; NIH/NIDA [1DP1DA033524]; NIH/NIAID
[5R01AI068761]; Maurice E. Muller Foundation of switzerland; Swiss
National Foundation [3100A0-108299]; Swiss systems biology initiative
SystemsX.ch (grant CINA)
FX Support by the NIH/NIGMS (award 1P01GM096971), the NIH/NIDA (award
1DP1DA033524) and the NIH/NIAID (award 5R01AI068761) for this work is
gratefully acknowledged. The STEM microscopy was funded by the Maurice
E. Muller Foundation of switzerland and Swiss National Foundation Grant
3100A0-108299 to Andreas Engel and by the Swiss systems biology
initiative SystemsX.ch (grant CINA to Andreas Engel and Henning
Stahlberg).
NR 44
TC 5
Z9 5
U1 6
U2 21
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1549-9634
EI 1549-9642
J9 NANOMED-NANOTECHNOL
JI Nanomed.-Nanotechnol. Biol. Med.
PD OCT
PY 2015
VL 11
IS 7
BP 1705
EP 1713
DI 10.1016/j.nano.2015.05.003
PG 9
WC Nanoscience & Nanotechnology; Medicine, Research & Experimental
SC Science & Technology - Other Topics; Research & Experimental Medicine
GA CX3JJ
UT WOS:000365594700011
PM 26051652
ER
PT J
AU Favreau-Farhadi, N
Pecukonis, L
Barrett, A
AF Favreau-Farhadi, Nicole
Pecukonis, Lauren
Barrett, Ann
TI The Inhibition of Maillard Browning by Different Concentrations of
Rosmarinic Acid and Epigallocatechin-3-Gallate in Model, Bakery, and
Fruit Systems
SO JOURNAL OF FOOD SCIENCE
LA English
DT Article
DE colorimetry; Epigallocatechin gallate; Maillard browning; pyrazine;
Rosmarinic acid
ID ANTIOXIDANT ACTIVITY; CARNOSIC ACID; PROOXIDANT PROPERTIES; ROSEMARY
EXTRACT; KINETICS; GLYCINE; GLUCOSE; CONSTITUENTS; PHENOLICS; OXIDATION
AB Rosmarinic acid and Epigallocatechin gallate concentrations were studied as natural inhibitors of Maillard browning in glucose/glycine model systems, and in bakery rolls and applesauce. The concentrations of the inhibitors were varied to determine the highest level of inhibition without a pro-oxidant/browning effect. UV absorbance and gas chromatography/mass spec (GC/MS) with solid phase microextraction (SPME) sampling was used to study browning in the model systems. Hunter L*, a*, b* was used to analyze the color change results of the inhibitors on applesauce and bakery rolls. It was determined that a 1.0% solution of either antioxidant in the glucose/glycine system produced the greatest inhibition and a synergistic effect was not apparent when the two were combined. Inhibition of browning and a lack of synergy between the antioxidants were also determined in food systems consisting of applesauce and bakery rolls. GC/MS analysis of the model system revealed a high level of pyrazine formation in no-inhibitor control samples and the absence of pyrazines in inhibitor-containing samples.
C1 [Favreau-Farhadi, Nicole; Pecukonis, Lauren; Barrett, Ann] US Army, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA.
RP Favreau-Farhadi, N (reprint author), US Army, Natick Soldier Res Dev & Engn Ctr, 15 Kansas St, Natick, MA 01760 USA.
EM Nicole.f.farhadi.civ@mail.mil
NR 42
TC 0
Z9 0
U1 9
U2 17
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-1147
EI 1750-3841
J9 J FOOD SCI
JI J. Food Sci.
PD OCT
PY 2015
VL 80
IS 10
BP C2140
EP C2146
DI 10.1111/1750-3841.13014
PG 7
WC Food Science & Technology
SC Food Science & Technology
GA CW1WW
UT WOS:000364783600005
PM 26408937
ER
PT J
AU Taylor, KF
Meyer, VM
Smith, LB
Lustik, MB
AF Taylor, Kenneth F.
Meyer, Vanessa M.
Smith, Laurel B.
Lustik, Michael B.
TI Multiplanar wrist joint proprioception: The effect of anesthetic
blockade of the posterior interosseous nerve or skin envelope
surrounding the joint
SO JOURNAL OF HAND THERAPY
LA English
DT Article
DE Proprioception; Wrist; Posterior interosseous nerve; Joint position
sense
ID POSITION SENSE; DENERVATION; KINESTHESIA; SHOULDER; REFLEXES; HAND
AB Study design: Randomized clinical trial.
Purpose: Contribution of the posterior interosseous nerve (PIN) and surrounding skin envelope to wrist proprioception is a topic of debate and the primary focus of this research.
Methods: We performed a double-blinded, placebo control study in which subjects underwent baseline multiplanar testing of wrist proprioception. They were randomized to receive either anesthetic blockade of the PIN within the fourth dorsal compartment, or circumferential topical anesthetic blockade of skin surrounding the wrist. Corresponding opposite wrists underwent placebo intervention with saline injection or inert ultrasound gel. Subjects repeated proprioceptive testing.
Results: Eighty subjects, 45 male and 35 female, mean age 33 years (range, 19-64 years), completed testing. The percentage of measurements falling outside a +/- 18 degrees range did not differ between pretreatment and post-treatment PIN blockade or for circumferential skin anesthesia.
Conclusions: Wrist proprioception appears to be a multifactorial phenomenon. Surgeons may sacrifice the PIN without concern for effect on joint proprioception. (C) 2015 Hanley & Belfus, an imprint of Elsevier Inc. All rights reserved.
C1 [Taylor, Kenneth F.] Penn State Milton S Hershey Med Ctr, Dept Orthopaed Surg & Rehabil, Hershey, PA 17033 USA.
[Meyer, Vanessa M.] Brooke Army Med Ctr, Dept Orthoped & Rehabil, Ft Sam Houston, TX 78234 USA.
[Smith, Laurel B.] US Army Res Inst Environm Med, Mil Performance Div, Natick, MA USA.
[Lustik, Michael B.] Tripler Army Med Ctr, Dept Clin Invest, Honolulu, HI 96859 USA.
RP Taylor, KF (reprint author), Penn State Milton S Hershey Med Ctr, Dept Orthopaed & Rehabil, 30 Hope Dr,POB 859, Hershey, PA 17033 USA.
EM ktaylor3@hmc.psu.edu
NR 26
TC 0
Z9 0
U1 0
U2 5
PU HANLEY & BELFUS-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0894-1130
EI 1545-004X
J9 J HAND THER
JI J. Hand Ther.
PD OCT-DEC
PY 2015
VL 28
IS 4
BP 369
EP 374
DI 10.1016/j.jht.2015.03.003
PG 6
WC Orthopedics; Rehabilitation; Surgery
SC Orthopedics; Rehabilitation; Surgery
GA CW2EG
UT WOS:000364803300006
PM 26209163
ER
PT J
AU Gu, S
Pasqualetti, F
Cieslak, M
Telesford, QK
Yu, AB
Kahn, AE
Medaglia, JD
Vettel, JM
Miller, MB
Grafton, ST
Bassett, DS
AF Gu, Shi
Pasqualetti, Fabio
Cieslak, Matthew
Telesford, Qawi K.
Yu, Alfred B.
Kahn, Ari E.
Medaglia, John D.
Vettel, Jean M.
Miller, Michael B.
Grafton, Scott T.
Bassett, Danielle S.
TI Controllability of structural brain networks
SO NATURE COMMUNICATIONS
LA English
DT Article
ID RICH-CLUB ORGANIZATION; STATE FUNCTIONAL CONNECTIVITY; RESTING-STATE;
COGNITIVE CONTROL; HUMAN CONNECTOME; SYSTEMS; SCHIZOPHRENIA; HUBS;
RECONSTRUCTION; ARCHITECTURE
AB Cognitive function is driven by dynamic interactions between large-scale neural circuits or networks, enabling behaviour. However, fundamental principles constraining these dynamic network processes have remained elusive. Here we use tools from control and network theories to offer a mechanistic explanation for how the brain moves between cognitive states drawn from the network organization of white matter microstructure. Our results suggest that densely connected areas, particularly in the default mode system, facilitate the movement of the brain to many easily reachable states. Weakly connected areas, particularly in cognitive control systems, facilitate the movement of the brain to difficult-to-reach states. Areas located on the boundary between network communities, particularly in attentional control systems, facilitate the integration or segregation of diverse cognitive systems. Our results suggest that structural network differences between cognitive circuits dictate their distinct roles in controlling trajectories of brain network function.
C1 [Gu, Shi] Univ Penn, Dept Appl Math & Computat Sci, Philadelphia, PA 19104 USA.
[Gu, Shi; Telesford, Qawi K.; Kahn, Ari E.; Medaglia, John D.; Bassett, Danielle S.] Univ Penn, Dept Bioengn, Philadelphia, PA 19104 USA.
[Pasqualetti, Fabio] Univ Calif Riverside, Dept Mech Engn, Riverside, CA 92521 USA.
[Cieslak, Matthew; Vettel, Jean M.; Miller, Michael B.; Grafton, Scott T.] Univ Calif Santa Barbara, Dept Psychol & Brain Sci, Santa Barbara, CA 93106 USA.
[Telesford, Qawi K.; Yu, Alfred B.; Vettel, Jean M.] Army Res Lab, Translat Neurosci Branch, Aberdeen, MD 20783 USA.
[Bassett, Danielle S.] Univ Penn, Dept Elect & Syst Engn, Philadelphia, PA 19104 USA.
RP Bassett, DS (reprint author), Univ Penn, Dept Bioengn, Philadelphia, PA 19104 USA.
EM dsb@seas.upenn.edu
OI Pasqualetti, Fabio/0000-0002-8457-8656
FU Alfred P. Sloan Foundation; Army Research Laboratory through contract
from the U.S. Army Research Office [W911NF-10-2-0022]; Institute for
Translational Medicine and Therapeutics at Penn; National Science
Foundation award [BCS-1441502, BCS-1430279]; Applied Mathematics and
Computational Science Graduate Program at the University of
Pennsylvania; PHS [NS44393]; Institute for Collaborative Biotechnologies
through grant from the U.S. Army Research Office [W911NF-09-0001]
FX D.S.B. acknowledges support from the Alfred P. Sloan Foundation, the
Army Research Laboratory through contract no. W911NF-10-2-0022 from the
U.S. Army Research Office, the Institute for Translational Medicine and
Therapeutics at Penn and the National Science Foundation award
#BCS-1441502. S.G. acknowledges support from the Applied Mathematics and
Computational Science Graduate Program at the University of
Pennsylvania. M.C. and S.T.G. were supported by PHS Grant NS44393 and
the Institute for Collaborative Biotechnologies through grant
W911NF-09-0001 from the U.S. Army Research Office. F.P. acknowledges
support from the National Science Foundation award #BCS-1430279. The
content is solely the responsibility of the authors and does not
necessarily represent the official views of any of the funding agencies.
NR 67
TC 18
Z9 18
U1 9
U2 21
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2041-1723
J9 NAT COMMUN
JI Nat. Commun.
PD OCT
PY 2015
VL 6
AR 8414
DI 10.1038/ncomms9414
PG 10
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CW3WN
UT WOS:000364923100001
PM 26423222
ER
PT J
AU Terrell, JL
Wu, HC
Tsao, CY
Barber, NB
Servinsky, MD
Payne, GF
Bentley, WE
AF Terrell, Jessica L.
Wu, Hsuan-Chen
Tsao, Chen-Yu
Barber, Nathan B.
Servinsky, Matthew D.
Payne, Gregory F.
Bentley, William E.
TI Nano-guided cell networks as conveyors of molecular communication
SO NATURE COMMUNICATIONS
LA English
DT Article
ID SENSING AUTOINDUCER AI-2; ESCHERICHIA-COLI; SYNTHETIC BIOLOGY;
GENE-EXPRESSION; BACTERIA; BIOSENSORS; MICROBES; PROTEINS; SYSTEMS;
CANCER
AB Advances in nanotechnology have provided unprecedented physical means to sample molecular space. Living cells provide additional capability in that they identify molecules within complex environments and actuate function. We have merged cells with nanotechnology for an integrated molecular processing network. Here we show that an engineered cell consortium autonomously generates feedback to chemical cues. Moreover, abiotic components are readily assembled onto cells, enabling amplified and 'binned' responses. Specifically, engineered cell populations are triggered by a quorum sensing (QS) signal molecule, autoinducer-2, to express surface-displayed fusions consisting of a fluorescent marker and an affinity peptide. The latter provides means for attaching magnetic nanoparticles to fluorescently activated subpopulations for coalescence into colour-indexed output. The resultant nano-guided cell network assesses QS activity and conveys molecular information as a 'bio-litmus' in a manner read by simple optical means.
C1 [Terrell, Jessica L.; Wu, Hsuan-Chen; Tsao, Chen-Yu; Barber, Nathan B.; Payne, Gregory F.; Bentley, William E.] Univ Maryland, Fischell Dept Bioengn, College Pk, MD 20742 USA.
[Terrell, Jessica L.; Wu, Hsuan-Chen; Tsao, Chen-Yu; Payne, Gregory F.; Bentley, William E.] Univ Maryland, Inst Biosci & Biotechnol Res, College Pk, MD 20742 USA.
[Servinsky, Matthew D.] US Army Res Lab, Adelphi, MD 20783 USA.
RP Bentley, WE (reprint author), Univ Maryland, Fischell Dept Bioengn, 2330 Jeong H Kim Engn Bldg, College Pk, MD 20742 USA.
EM Bentley@umd.edu
OI WU, HSUAN-CHEN/0000-0002-7837-1333
FU NSF as a MRSEC; Defense Threat Reduction Agency [HDTRA1-13-1-0037];
National Science Foundation [CBET 1160005, CBET 1264509, CBET 1435957];
United States Department of Agriculture [NIFA 2014-67021-21585]
FX We acknowledge the University of Maryland's Bioengineering Core Cell
Analyzer facilities for provision of FACS equipment. We also thank the
Maryland NanoCenter for providing SEM imaging assistance through the
Nanoscale Imaging, Spectroscopy and Properties Laboratory (NISPLab). The
NISPLab is supported in part by the NSF as a MRSEC Shared Experimental
Facility. This work was financially supported by the Defense Threat
Reduction Agency (HDTRA1-13-1-0037), the National Science Foundation
(CBET 1160005, CBET 1264509 and CBET 1435957) and the United States
Department of Agriculture (NIFA 2014-67021-21585).
NR 63
TC 3
Z9 3
U1 9
U2 40
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2041-1723
J9 NAT COMMUN
JI Nat. Commun.
PD OCT
PY 2015
VL 6
AR 8500
DI 10.1038/ncomms9500
PG 12
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CW3YT
UT WOS:000364929000002
PM 26455828
ER
PT J
AU Miller, AK
Hensman, MC
Hensman, S
Schultz, K
Reid, P
Shore, M
Brown, J
Furton, KG
Lee, S
AF Miller, Ashadee Kay
Hensman, Michael C.
Hensman, Sean
Schultz, Kip
Reid, Paul
Shore, Mike
Brown, Jessica
Furton, Kenneth G.
Lee, Stephen
TI African elephants (Loxodonta africana) can detect TNT using olfaction:
Implications for biosensor application
SO APPLIED ANIMAL BEHAVIOUR SCIENCE
LA English
DT Article
DE Landmine detection; Olfactory acuity; African elephant
ID RECEPTOR GENE REPERTOIRE; DOGS CANIS-FAMILIARIS; SEIZURE-ALERT DOGS;
ACCELERANT DETECTION; SEARCH IMAGE; TRAINED DOGS; ODOR; EXPLOSIVES;
TERMITE; ABILITY
AB The impact of war on local wildlife can be devastating, the effects of which are often felt well beyond the terminus of the initial threat. In areas where wildlife experiences unrestricted movement through previously affected zones, residual, unexploded landmines present a significant and potentially lethal problem. Anecdotal reports of African elephants (Loxodonta africana), in a once war-torn Angola, avoiding minefields together with telemetry data suggest that the species may be able to detect concealed landmines using olfaction. Before any in-field experiments can be conducted, an elephant's olfactory capacity for the detection of the most commonly used component in landmines, trinitrotoluene (TNT), needed to be established. Using three African elephants under controlled conditions, we used operant conditioning to test whether elephants are able to detect and reliably indicate the presence of TNT using olfaction. Elephants detected and indicated TNT using olfaction at levels greater than chance, with high sensitivity and selectivity, even when in the presence of highly volatile distractor odors. Additionally, the sensitivity of detection surpasses that of TNT-detection dogs working under similar conditions, suggesting that the potential application of African elephants within the biosensor-field should not be underestimated. (C) 2015 Elsevier B.V. All rights reserved.
C1 [Miller, Ashadee Kay] Univ Witwatersrand, Anim Plant & Environm Sci, ZA-2050 Johannesburg, South Africa.
[Hensman, Michael C.; Hensman, Sean] Adventures Elephant, ZA-0480 Bela Bela, Limpopo, South Africa.
[Schultz, Kip] Bikota Solut, Perkins, OK 74059 USA.
[Reid, Paul; Shore, Mike; Lee, Stephen] US Army, Res Off, Res Triangle Pk, NC 27709 USA.
[Brown, Jessica; Furton, Kenneth G.] Florida Int Univ, Dept Chem & Biochem, Miami, FL 33199 USA.
RP Miller, AK (reprint author), Univ Witwatersrand, Anim Plant & Environm Sci, Private Bag 3, ZA-2050 Johannesburg, South Africa.
EM ashadee.k.miller@gmail.com
FU U.S. Army International Technology Centre-London [W911NK-12-1-0303]
FX We thank Graham Alexander for reading draft versions of this manuscript.
Funding was provided by the U.S. Army International Technology
Centre-London under grant number W911NK-12-1-0303. All animal protocols
were cleared by the Florida International University's Institutional
Animal Care and Use Committee under permit number IACUC-14-008.
NR 68
TC 0
Z9 0
U1 10
U2 33
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0168-1591
EI 1872-9045
J9 APPL ANIM BEHAV SCI
JI Appl. Anim. Behav. Sci.
PD OCT
PY 2015
VL 171
BP 177
EP 183
DI 10.1016/j.applanim.2015.08.003
PG 7
WC Agriculture, Dairy & Animal Science; Behavioral Sciences; Veterinary
Sciences
SC Agriculture; Behavioral Sciences; Veterinary Sciences
GA CV9KD
UT WOS:000364605200023
ER
PT J
AU Tucker, CR
Strickland, JT
Edmond, BS
Delaney, DK
Ligon, DB
AF Tucker, Charles R.
Strickland, Jeramie T.
Edmond, Brian S.
Delaney, David K.
Ligon, Day B.
TI Activity Patterns of Ornate Box Turtles (Terrapene omata) in
Northwestern Illinois
SO COPEIA
LA English
DT Article
ID AUTOMATED RADIO TELEMETRY; TEMPERATURE; SNAKES; POPULATION; ECOLOGY;
RHYTHMS; THERMOREGULATION; DETERMINANTS; CONSTRAINTS; ENVIRONMENT
AB Activity patterns of ectothermic animals are affected by weather, time of day, and season, but quantifying these effects can be logistically challenging. We used an automated radio telemetry system to quantify Ornate Box Turtle (Terrapene ornata) activity patterns for two years in northern Illinois. Continuously collected activity data were paired with meteorological data collected from the site to determine factors influencing turtle behavior. Temperature, relative humidity, rain, year, month, time of day, and reproductive status affected activity levels. Increased activity levels corresponded with rain events, and males were generally more active than females, especially during spring and late summer. Overall, turtles were less active during an uncharacteristically warm and dry year compared to a year with conditions that were closer to the long-term average. Bimodal daily activity patterns have been reported in more southerly populations, and we found similar patterns near the species' northern range limit, indicating that thermal constraints may limit activity of this species across its range. Activity comparisons between a year with normal meteorological conditions and an abnormally warm and dry year provide insight to the effect that further onset of climate change may have on the activity of Ornate Box Turtles.
C1 [Tucker, Charles R.; Ligon, Day B.] Missouri State Univ, Dept Biol, Springfield, MO 65897 USA.
[Strickland, Jeramie T.] Upper Mississippi River Natl Wildlife & Fish Refu, Thomson, IL 61285 USA.
[Edmond, Brian S.] Missouri State Univ, Comp Serv, Springfield, MO 65897 USA.
[Delaney, David K.] US Army Construct Engn Res Lab, Champaign, IL 61826 USA.
RP Ligon, DB (reprint author), POB 100, Roosevelt, MN 56673 USA.
EM DayLigon@Missouristate.edu
FU Upper Mississippi River National Wildlife and Fish Refuge; NASA-Missouri
Space Consortium
FX We thank the Upper Mississippi River National Wildlife and Fish Refuge,
and especially E. Britton, for project funding and continuous support
and encouragement. Thanks as well to E. Tomasovic for assistance with
telemetry tower maintenance and to Dr. F. Janzen's Iowa State University
"Turtle Camp" group for assistance with capturing study animals and for
sharing the study site. Thanks to T. Radzio for technical advice and to
the NASA-Missouri Space Consortium for funding. This project was made
possible by a generous equipment loan from the United States Army
Construction Engineering Research Laboratory. All procedures for this
study were approved by the Missouri State University Institutional
Animal Care and Use Committee (protocol 120011). Research was conducted
under Illinois Department of Natural Resources permit 10-15S. The
findings and conclusions in this article are those of the authors and do
not necessarily represent the views of the U.S. Fish and Wildlife
Service or the U.S. Army Construction Engineering Research Laboratory.
NR 44
TC 1
Z9 1
U1 3
U2 11
PU AMER SOC ICHTHYOLOGISTS & HERPETOLOGISTS
PI MIAMI
PA MAUREEN DONNELLY, SECRETARY FLORIDA INT UNIV BIOLOGICAL SCIENCES, 11200
SW 8TH STREET, MIAMI, FL 33199 USA
SN 0045-8511
EI 1938-5110
J9 COPEIA
JI Copeia
PD OCT
PY 2015
VL 103
IS 3
BP 502
EP 511
DI 10.1643/CH-15-249
PG 10
WC Zoology
SC Zoology
GA CV7FM
UT WOS:000364437800002
ER
PT J
AU Borel, C
Rosario, D
Romano, J
AF Borel, Christoph
Rosario, Dalton
Romano, Joao
TI Data processing and temperature-emissivity separation for tower-based
imaging Fourier transform spectrometer data
SO INTERNATIONAL JOURNAL OF REMOTE SENSING
LA English
DT Article; Proceedings Paper
CT 4th International Symposium on Recent Advances in Quantitative Remote
Sensing (RAQRS)
CY SEP 22-26, 2014
CL Global Change Unit Univ Valencia, Torrent, SPAIN
SP Global Change Unit Univ Valencia, City Council Torrent, European Space Agcy, Inst Nacl Tecn Aeroesp, Minist Def Spain, Airbus Def and Space, Elecnor Deimos Imaging EOLAB SL, SM GEODIM
HO Global Change Unit Univ Valencia
AB In this article we describe the end-to-end processing of image Fourier transform spectrometry data taken at Picatinny Arsenal in New Jersey with the long-wave hyperspectral camera manufactured by the Telops company. The first part of the article discusses the processing from raw data to calibrated radiance and emissivity data. Data were taken during several months under different weather conditions every 6min from a 213 ft-high tower of surrogate tank targets for a project sponsored by the Army Research Laboratory in Adelphi, Maryland. The second part discusses environmental effects such as diurnal and seasonal atmospheric and temperature changes and the effect of cloud cover on the data. To test the effect of environmental conditions, a range-invariant anomaly detection approach is applied to calibrate radiance, brightness temperature, and emissivity data. The data set presented in this article is due to be released publicly so that more detailed studies can be performed not only on the man-made targets but also on the changes of natural background of vegetation and gravel with time of day and seasons.
C1 [Borel, Christoph] Air Force Inst Technol, CTISR, Dept Engn Phys, Dayton, OH 45433 USA.
[Rosario, Dalton] US Army Res Lab, Adelphi, MD 20783 USA.
[Romano, Joao] US Army Armament RDEC, Picatinny Arsenal, Wharton, NJ 07806 USA.
EM cborel@afit.edu
NR 9
TC 2
Z9 2
U1 0
U2 6
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0143-1161
EI 1366-5901
J9 INT J REMOTE SENS
JI Int. J. Remote Sens.
PD OCT
PY 2015
VL 36
IS 19-20
SI SI
BP 4779
EP 4792
DI 10.1080/01431161.2015.1047996
PG 14
WC Remote Sensing; Imaging Science & Photographic Technology
SC Remote Sensing; Imaging Science & Photographic Technology
GA CV5TQ
UT WOS:000364334500002
ER
PT J
AU Shi, QQ
Reasor, D
Gao, Z
Li, XL
Charles, RD
AF Shi, Qiangqiang
Reasor, Daniel
Gao, Zheng
Li, Xiaolin
Charles, Richard D.
TI On the verification and validation of a spring fabric for modeling
parachute inflation
SO JOURNAL OF FLUIDS AND STRUCTURES
LA English
DT Article
DE Elastic membrane; Spring model; Parachute inflation
ID NAVIER-STOKES EQUATIONS; IMMERSED BOUNDARY METHOD; FLUID PHYSICS;
SIMULATION; TRACKING; CANOPY
AB A mesoscale spring-mass model is used to mimic fabric surface motion. Through coupling with an incompressible fluid solver, the spring-mass model is applied to the simulation of the dynamic phenomenon of parachute inflation. A presentation of a verification and validation efforts is included. The present model is shown to be numerically convergent under the constraints that the summation of point masses is constant and that both the tensile stiffness and the angular stiffness of the spring conform with the material's Young modulus and Poisson ratio. Complex validation simulations conclude the effort via drag force comparisons with experiments. (C) 2015 Published by Elsevier Ltd.
C1 [Shi, Qiangqiang; Gao, Zheng; Li, Xiaolin] SUNY Stony Brook, Dept Appl Math & Stat, Stony Brook, NY 11794 USA.
[Reasor, Daniel] Test Support Squadron Testing Tech, Edwards Afb, CA 93524 USA.
[Charles, Richard D.] US Army, Natick Res Dev & Engn Ctr NSRDEC, Airdrop Technol Team, Natick, MA 01760 USA.
RP Shi, QQ (reprint author), SUNY Stony Brook, Dept Appl Math & Stat, Stony Brook, NY 11794 USA.
FU US Army Research Office [W911NF0910306, W911NF1410428]; ARO-DURIP
[W911NF1210357]; Air Force Summer Faculty Fellowship
FX We would like to thank Dr. Joseph Myers of the ARO for fostering the
collaborative relationship between authors at Stony Brook University and
the Army scientists, and Dr. Michael Kendra for the support with Air
Force Summer Faculty Fellowship to Edwards AFB. We would like to give
special thanks to Jean Potvin at St. Louis University for providing the
experimental data on the drag of the C-9 parachute, Alec Dyatt for
giving us valuable suggestions on the direction of the research, and
Keerti Bhamidipati for many fruitful discussions while Xiaolin Li was
working at the Edwards AFB. Also thanks to Yiyang Yang for helping to
make some of the figures. This work is supported in part by the US Army
Research Office under the award W911NF0910306, W911NF1410428 and the
ARO-DURIP Grant W911NF1210357.
NR 36
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U1 3
U2 5
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 0889-9746
J9 J FLUID STRUCT
JI J. Fluids Struct.
PD OCT
PY 2015
VL 58
BP 20
EP 39
DI 10.1016/j.jfluidstructs.2015.06.014
PG 20
WC Engineering, Mechanical; Mechanics
SC Engineering; Mechanics
GA CV4PE
UT WOS:000364248200002
ER
PT J
AU Follum, ML
Downer, CW
Niemann, JD
Roylance, SM
Vuyovich, CM
AF Follum, Michael L.
Downer, Charles W.
Niemann, Jeffrey D.
Roylance, Spencer M.
Vuyovich, Carrie M.
TI A radiation-derived temperature-index snow routine for the GSSHA
hydrologic model
SO JOURNAL OF HYDROLOGY
LA English
DT Article
DE Spatial snow simulation; Spatially-distributed watershed model;
Radiation-derived temperature-index snow model; Topographic effects on
snow
ID INCOMING LONGWAVE RADIATION; MELTING SNOW; SPATIAL-DISTRIBUTION; ENERGY
BUDGET; RUNOFF MODEL; FOREST; ACCUMULATION; MOUNTAIN; BASIN; AREAS
AB Accurate estimation of snowpack is vital in many parts of the world for both water management and flood prediction. Temperature-index (TI) snowmelt models are commonly used for this purpose due to their simplicity and low data requirements. Although TI models work well within lumped watershed models, their reliance on air temperature (and potentially an assumed lapse rate) as the only external driver of snowmelt limits their ability to accurately simulate the spatial distribution of snowpack and thus the timing of snowmelt, This limitation significantly reduces the utility of the TI approach in distributed hydrologic models because spatial variability within the watershed, including snowpack and snowmelt, is usually the primary reason for selecting a distributed model. In this paper, a new radiation-derived temperature index (RTI) approach is presented that uses a spatially-varying proxy temperature in place of air temperature within the TI model of the fully-distributed Gridded Surface Subsurface Hydrologic Analysis (GSSHA) watershed model. The RTI is derived from a radiation balance and includes spatial heterogeneity in both shortwave and longwave radiation. Thus, the RTI accounts for more local variation in the available energy than air temperature alone. The RTI model in GSSHA is tested at the Senator Beck basin in southwestern Colorado where observations for snow water equivalent (SWE) and LandSatderived images of snow cover area (SCA) are available. The TI and RTI approaches produce similar SWE estimates at two non-forested and relatively flat sites with SWE observations. However, the two models can produce very different SWE values at sites with forests or topographic slopes, which leads to significant differences in the basin-wide SWE values of the two models. Furthermore, the RTI model provides better basin-wide SCA estimates than the TI model in 75% of the LandSat images analyzed. Published by Elsevier B.V.
C1 [Follum, Michael L.; Downer, Charles W.] Engn Res & Dev Ctr, Coastal & Hydraul Lab, Hydrol Syst Branch, Vicksburg, MS 39180 USA.
[Follum, Michael L.; Niemann, Jeffrey D.] Colorado State Univ, Dept Civil Engn, Ft Collins, CO 80523 USA.
[Roylance, Spencer M.] US Army, Corps Engineers, Wilmington, NC 28403 USA.
[Vuyovich, Carrie M.] Engn Res & Dev Ctr, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA.
RP Follum, ML (reprint author), Engn Res & Dev Ctr, Coastal & Hydraul Lab, Hydrol Syst Branch, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
EM Michael.L.Follum@usace.army.mil
FU Flood and Coastal Research Program at the U.S. Army Corps of Engineers,
Engineering Research and Development Center, Coastal and Hydraulics
Laboratory in Vicksburg, Mississippi
FX This project was funded by the Flood and Coastal Research Program at the
U.S. Army Corps of Engineers, Engineering Research and Development
Center, Coastal and Hydraulics Laboratory in Vicksburg, Mississippi. We
also thank three anonymous reviewers who provided helpful comments that
substantially improved this article.
NR 80
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U1 3
U2 7
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0022-1694
EI 1879-2707
J9 J HYDROL
JI J. Hydrol.
PD OCT
PY 2015
VL 529
BP 723
EP 736
DI 10.1016/j.jhydrol.2015.08.044
PN 3
PG 14
WC Engineering, Civil; Geosciences, Multidisciplinary; Water Resources
SC Engineering; Geology; Water Resources
GA CV4PR
UT WOS:000364249500004
ER
PT J
AU Baird, CP
AF Baird, Coleen P.
TI Maximizing the Utility of the Serum Repository With Current Technologies
and Recommendations to Meet Future Needs: Report of the Technical Panel
SO MILITARY MEDICINE
LA English
DT Article
ID OMIC TECHNOLOGIES; EXPOSURE SCIENCE; DNA EXTRACTION; EXPOSOME;
EPIDEMIOLOGY; PRIMER
AB The Department of Defense Serum Repository (DoDSR) of the Armed Forces Health Surveillance Center (AFHSC), Silver Spring, Maryland, has over 55 million specimens. Over 80% of these specimens are linked to individual health data. In response to Congressional and Department of Defense (DoD) concern about toxic exposures of deployed Service members and rapidly developing laboratory capabilities that may identify those exposed, the AFHSC hosted two panels in 2013. The first, the Needs Panel, focused on assessing the needs of the DoD that may be met using the current DoDSR and an enhanced repository. The second panel, the Technical Panel, focused on identifying the emerging laboratory technologies that are or will be available to DoD public health workers and researchers. This report summarizes the recommendations of the Technical Panel, to include identified gaps in the ability of the current DoDSR to address questions of interest to the DoD, the availability of laboratory technology to address these needs, and the types and quality of specimens required from Service members possibly exposed.
C1 US Army Publ Hlth Command, Environm Med, Aberdeen Proving Ground, MD 21010 USA.
RP Baird, CP (reprint author), US Army Publ Hlth Command, Environm Med, 5158 Black Hawk Rd, Aberdeen Proving Ground, MD 21010 USA.
NR 26
TC 0
Z9 0
U1 0
U2 0
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD OCT
PY 2015
VL 180
IS 10
SU S
BP 26
EP 33
DI 10.7205/MILMED-D-15-00065
PG 8
WC Medicine, General & Internal
SC General & Internal Medicine
GA CV9UW
UT WOS:000364633800006
ER
PT J
AU Bowen, CG
Greenwood, W
Guevara, P
Washington, MA
AF Bowen, Christopher G.
Greenwood, William
Guevara, Pete
Washington, Michael A.
TI Effectiveness of a Dental Unit Waterline Treatment Protocol With A-Dec
ICX and Citrisil Disinfectants
SO MILITARY MEDICINE
LA English
DT Article
ID BACTERIAL-CONTAMINATION; TEST KITS; BIOFILM; LINES; RETRACTION;
MANAGEMENT; REDUCTION; INFECTION; OUTBREAK; SYSTEM
AB This study evaluated the effectiveness of a Dental Unit Waterline disinfection protocol utilizing two waterline disinfectant tablets in a dental treatment clinic. The water effluent from 47 dental treatment units was sampled to determine bacterial load. Four dental treatment units were shocked with the multivalent Sterilex Ultra liquid biocide, followed by a 5-week course of routine disinfection using either the A-dec ICX or Citrisil effervescing tablets. Aseptic samples were taken twice weekly, and bacterial load was determined. No significant difference was found when comparing A-dec ICX with Citrisil, but a significant difference was seen between the use of either tablet and no tablet. In addition, a survey was conducted to evaluate the effect of user compliance on infection control. The results indicate that proper training, coupled with the use of appropriate disinfectants and shock treatment, are important aspects of maintaining low bacterial burden in dental water lines.
C1 [Bowen, Christopher G.; Greenwood, William; Guevara, Pete] Schofield Barracks Dent Clin, Schofield Barracks, HI 96857 USA.
[Washington, Michael A.] Tripler Army Med Ctr, Dept Clin Invest, Honolulu, HI 96818 USA.
RP Bowen, CG (reprint author), Schofield Barracks Dent Clin, Bldg 660 McCornack Rd, Schofield Barracks, HI 96857 USA.
FU AEGD-2 Comprehensive Dentistry Residency at Schofield Barracks Dental
Clinic, Tripler Hawaii DENTAC
FX We thank Dr. Sharon Esser, PhD, Mike Lustik at Department of Clinical
Investigation, Tripler Army Medical Center for the development and
statistical analysis portions of this research project. Also, we would
like to recognize the team of AEGD-2 research assistants which consisted
of Marcus Arcibal, Lynise Foley, Gerlie Espiritu, Maribel Valenciano,
Jennifer Matsumoto, and Elizabeth Harris. This research project was
fully funded by the AEGD-2 Comprehensive Dentistry Residency at
Schofield Barracks Dental Clinic, Tripler Hawaii DENTAC.
NR 36
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U1 2
U2 2
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD OCT
PY 2015
VL 180
IS 10
BP 1098
EP 1104
DI 10.7205/MILMED-D-14-00643
PG 7
WC Medicine, General & Internal
SC General & Internal Medicine
GA CV9UP
UT WOS:000364632900023
PM 26444474
ER
PT J
AU Nelmes, G
AF Nelmes, Gwen
TI "Angels in Army Drab": The Medical Specialists Corps and COL Emma Vogel
SO MILITARY MEDICINE
LA English
DT Editorial Material
C1 US Army Med Res & Mat Command, Amer Registry Pathol, Natl Museum Hlth & Med, Silver Spring, MD 20910 USA.
RP Nelmes, G (reprint author), US Army Med Res & Mat Command, Amer Registry Pathol, Natl Museum Hlth & Med, 2500 Linden Lane, Silver Spring, MD 20910 USA.
NR 6
TC 0
Z9 0
U1 0
U2 0
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD OCT
PY 2015
VL 180
IS 10
BP 1105
EP 1106
DI 10.7205/MILMED-D-15-00219
PG 2
WC Medicine, General & Internal
SC General & Internal Medicine
GA CV9UP
UT WOS:000364632900024
PM 26444475
ER
PT J
AU Vital-Lopez, FG
Reifman, J
Wallqvist, A
AF Vital-Lopez, Francisco G.
Reifman, Jaques
Wallqvist, Anders
TI Biofilm Formation Mechanisms of Pseudomonas aeruginosa Predicted via
Genome-Scale Kinetic Models of Bacterial Metabolism
SO PLOS COMPUTATIONAL BIOLOGY
LA English
DT Article
ID GENETIC-DETERMINANTS; TRANSCRIPTOME ANALYSIS; FUNCTIONAL GENOMICS;
VIRULENCE FACTORS; NETWORK ANALYSIS; RESISTANCE; RESISTOME;
SUSCEPTIBILITY; IDENTIFICATION; EXPRESSION
AB A hallmark of Pseudomonas aeruginosa is its ability to establish biofilm-based infections that are difficult to eradicate. Biofilms are less susceptible to host inflammatory and immune responses and have higher antibiotic tolerance than free-living planktonic cells. Developing treatments against biofilms requires an understanding of bacterial biofilm-specific physiological traits. Research efforts have started to elucidate the intricate mechanisms underlying biofilm development. However, many aspects of these mechanisms are still poorly understood. Here, we addressed questions regarding biofilm metabolism using a genome-scale kinetic model of the P. aeruginosa metabolic network and gene expression profiles. Specifically, we computed metabolite concentration differences between known mutants with altered biofilm formation and the wild-type strain to predict drug targets against P. aeruginosa biofilms. We also simulated the altered metabolism driven by gene expression changes between biofilm and stationary growth-phase planktonic cultures. Our analysis suggests that the synthesis of important biofilm-related molecules, such as the quorumsensing molecule Pseudomonas quinolone signal and the exopolysaccharide Psl, is regulated not only through the expression of genes in their own synthesis pathway, but also through the biofilm-specific expression of genes in pathways competing for precursors to these molecules. Finally, we investigated why mutants defective in anthranilate degradation have an impaired ability to form biofilms. Alternative to a previous hypothesis that this biofilm reduction is caused by a decrease in energy production, we proposed that the dysregulation of the synthesis of secondary metabolites derived from anthranilate and chorismate is what impaired the biofilms of these mutants. Notably, these insights generated through our kinetic model-based approach are not accessible from previous constraint-based model analyses of P. aeruginosa biofilm metabolism. Our simulation results showed that plausible, non-intuitive explanations of difficult-to-interpret experimental observations could be generated by integrating genome-scale kinetic models with gene expression profiles.
C1 [Vital-Lopez, Francisco G.; Reifman, Jaques; Wallqvist, Anders] US Army Med Res & Mat Command, Dept Def Biotechnol High Performance Comp Softwar, Telemed & Adv Technol Res Ctr, Ft Detrick, MD USA.
RP Vital-Lopez, FG (reprint author), US Army Med Res & Mat Command, Dept Def Biotechnol High Performance Comp Softwar, Telemed & Adv Technol Res Ctr, Ft Detrick, MD USA.
EM jaques.reifman.civ@mail.mil
OI wallqvist, anders/0000-0002-9775-7469
FU U.S. Army Network Science Initiative; U.S. Army Medical Research and
Materiel Command, Fort Detrick, MD
FX The authors were supported by the U.S. Army Network Science Initiative,
U.S. Army Medical Research and Materiel Command, Fort Detrick, MD
(http://mrmc.amedd.army.mil). The funders had no role in study design,
data collection and analysis, decision to publish, or preparation of the
manuscript.
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PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1553-734X
EI 1553-7358
J9 PLOS COMPUT BIOL
JI PLoS Comput. Biol.
PD OCT
PY 2015
VL 11
IS 10
AR e1004452
DI 10.1371/journal.pcbi.1004452
PG 24
WC Biochemical Research Methods; Mathematical & Computational Biology
SC Biochemistry & Molecular Biology; Mathematical & Computational Biology
GA CV6SD
UT WOS:000364399700028
PM 26431398
ER
PT J
AU Erasmus, JH
Needham, J
Raychaudhuri, S
Diamond, MS
Beasley, DWC
Morkowski, S
Salje, H
Salas, IF
Kim, DY
Frolov, I
Nasar, F
Weaver, SC
AF Erasmus, Jesse H.
Needham, James
Raychaudhuri, Syamal
Diamond, Michael S.
Beasley, David W. C.
Morkowski, Stan
Salje, Henrik
Salas, Ildefonso Fernandez
Kim, Dal Young
Frolov, Ilya
Nasar, Farooq
Weaver, Scott C.
TI Utilization of an Eilat Virus-Based Chimera for Serological Detection of
Chikungunya Infection
SO PLoS Neglected Tropical Diseases
LA English
DT Article
ID DISEASE VIRUS; ALPHAVIRUS; REPLICATION; CULICIDAE; MOSQUITO; DIPTERA;
VECTOR; FRANCE; REGION; FEVER
AB In December of 2013, chikungunya virus (CHIKV), an alphavirus in the family Togaviridae, was introduced to the island of Saint Martin in the Caribbean, resulting in the first autochthonous cases reported in the Americas. As of January 2015, local and imported CHIKV has been reported in 50 American countries with over 1.1 million suspected cases. CHIKV causes a severe arthralgic disease for which there are no approved vaccines or therapeutics. Furthermore, the lack of a commercially available, sensitive, and affordable diagnostic assay limits surveillance and control efforts. To address this issue, we utilized an insect-specific alphavirus, Eilat virus (EILV), to develop a diagnostic antigen that does not require biosafety containment facilities to produce. We demonstrated that EILV/CHIKV replicates to high titers in insect cells and can be applied directly in enzyme-linked immunosorbent assays without inactivation, resulting in highly sensitive detection of recent and past CHIKV infection, and outperforming traditional antigen preparations.
C1 [Erasmus, Jesse H.; Weaver, Scott C.] Univ Texas Med Branch, Inst Translat Sci, Galveston, TX 77555 USA.
[Erasmus, Jesse H.; Nasar, Farooq; Weaver, Scott C.] Univ Texas Med Branch, Ctr Trop Dis, Galveston, TX 77555 USA.
[Needham, James; Raychaudhuri, Syamal; Morkowski, Stan] InBios Int Inc, Seattle, WA USA.
[Diamond, Michael S.] Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA.
[Diamond, Michael S.] Washington Univ, Sch Med, Dept Mol Microbiol, St Louis, MO 63110 USA.
[Diamond, Michael S.] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA.
[Beasley, David W. C.; Weaver, Scott C.] Univ Texas Med Branch, Inst Human Infect & Immun, Dept Microbiol & Immunol, Galveston, TX 77555 USA.
[Beasley, David W. C.] Univ Texas Med Branch, Ctr Biodef & Emerging Infect Dis, Galveston, TX 77555 USA.
[Beasley, David W. C.] Univ Texas Med Branch, Sealy Ctr Vaccine Dev, Galveston, TX 77555 USA.
[Salje, Henrik] Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA.
[Salje, Henrik] Inst Pasteur, Paris, France.
[Salas, Ildefonso Fernandez] Ctr Reg Invest Salud Publ INSP, Tapachula, Chiapas, Mexico.
[Kim, Dal Young; Frolov, Ilya] Univ Alabama Birmingham, Dept Microbiol, Birmingham, AL 35294 USA.
[Nasar, Farooq] US Army, Div Virol, Med Res Inst Infect Dis, Frederick, MD 21701 USA.
RP Erasmus, JH (reprint author), Univ Texas Med Branch, Inst Translat Sci, Galveston, TX 77555 USA.
EM sweaver@utmb.edu
RI Weaver, Scott/D-6490-2011;
OI Erasmus, Jesse/0000-0003-1612-2697; Salje, Henrik/0000-0003-3626-4254
FU National Institutes of Health [HHSN272201000040I / HHSN27200004 / D04,
R01-AI104545, UL1 TR001439]; McLaughlin Fellowship Fund
FX This work was supported by National Institutes of Health contract
HHSN272201000040I / HHSN27200004 / D04 and R01-AI104545 and UL1 TR001439
as well as the McLaughlin Fellowship Fund. The funders had no role in
study design, data collection and analysis, decision to publish, or
preparation of the manuscript.
NR 40
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U1 1
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PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1935-2735
J9 PLOS NEGLECT TROP D
JI Plos Neglect. Trop. Dis.
PD OCT
PY 2015
VL 9
IS 10
AR e0004119
DI 10.1371/journal.pntd.0004119
PG 16
WC Infectious Diseases; Parasitology; Tropical Medicine
SC Infectious Diseases; Parasitology; Tropical Medicine
GA CV7NC
UT WOS:000364459600026
PM 26492074
ER
PT J
AU Lakhal-Naouar, I
Slike, BM
Aronson, NE
Marovich, MA
AF Lakhal-Naouar, Ines
Slike, Bonnie M.
Aronson, Naomi E.
Marovich, Mary A.
TI The Immunology of a Healing Response in Cutaneous Leishmaniasis Treated
with Localized Heat or Systemic Antimonial Therapy
SO PLOS NEGLECTED TROPICAL DISEASES
LA English
DT Article
ID REGULATORY T-CELLS; RANDOMIZED CONTROLLED-TRIAL; TEGUMENTARY
LEISHMANIASIS; INTERFERON-GAMMA; IMMUNE-RESPONSE; CLINICAL CURE; MUCOSAL
LEISHMANIASIS; ACTIVE DISEASE; CD8(+); INFECTION
AB Background
The effectiveness of systemic antimonial (sodium stibogluconate, Pentostam, SSG) treatment versus local heat therapy (Thermomed) for cutaneous leishmaniasis was studied previously and showed similar healing rates. We hypothesized that different curative immune responses might develop with systemic and local treatment modalities.
Methods
We studied the peripheral blood immune cells in a cohort of 54 cutaneous Leishmania major subjects treated with SSG or TM. Multiparameter flow cytometry, lymphoproliferative assays and cytokine production were analyzed in order to investigate the differences in the immune responses of subjects before, on and after treatment.
Results
Healing cutaneous leishmaniasis lead to a significant decline in circulating T cells and NKT-like cells, accompanied by an expansion in NK cells, regardless of treatment modality. Functional changes involved decreased antigen specific CD4(+) T cell proliferation (hyporesponsiveness) seen with CD8(+) T cell depletion. Moreover, the healing (or healed) state was characterized by fewer circulating regulatory T cells, reduced IFN-gamma production and an overall contraction in polyfunctional CD4(+) T cells.
Conclusion
Healing from cutaneous Leishmaniasis is a dynamic process that alters circulating lymphocyte populations and subsets of T, NK and NKT-like cells. Immunology of healing, through local or systemic treatments, culminated in similar changes in frequency, quality, and antigen specific responsiveness with immunomodulation possibly via a CD8(+) T cell dependent mechanism. Understanding the evolving immunologic changes during healing of human leishmaniasis informs protective immune mechanisms.
C1 [Lakhal-Naouar, Ines; Aronson, Naomi E.] Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA.
[Lakhal-Naouar, Ines; Slike, Bonnie M.] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA.
[Slike, Bonnie M.; Marovich, Mary A.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA.
[Aronson, Naomi E.; Marovich, Mary A.] Walter Reed Natl Mil Med Ctr, Bethesda, MD USA.
RP Lakhal-Naouar, I (reprint author), Uniformed Serv Univ Hlth Sci, Dept Med, Room A3060, Bethesda, MD 20814 USA.
EM naomi.aronson@usuhs.edu
FU Department of Defense Global War on Terrorism funds; Henry M. Jackson
Foundation for the Advancement of Military Medicine, Inc.
[W81XWH-07-2-0067]; U.S. Department of Defense (DOD) [W81XWH-07-2-0067]
FX This work was supported by Department of Defense Global War on Terrorism
funds and by a cooperative agreement [W81XWH-07-2-0067] between the
Henry M. Jackson Foundation for the Advancement of Military Medicine,
Inc. and the U.S. Department of Defense (DOD). The funders had no role
in study design, data collection and analysis, decision to publish, or
preparation of the manuscript.
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PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1935-2735
J9 PLOS NEGLECT TROP D
JI Plos Neglect. Trop. Dis.
PD OCT
PY 2015
VL 9
IS 10
AR e0004178
DI 10.1371/journal.pntd.0004178
PG 17
WC Infectious Diseases; Parasitology; Tropical Medicine
SC Infectious Diseases; Parasitology; Tropical Medicine
GA CV7NC
UT WOS:000364459600071
PM 26485398
ER
PT J
AU Han, ZY
Madara, JJ
Herbert, A
Prugar, LI
Ruthel, G
Lu, JH
Liu, YL
Liu, WB
Liu, XH
Wrobel, JE
Reitz, AB
Dye, JM
Harty, RN
Freedman, BD
AF Han, Ziying
Madara, Jonathan J.
Herbert, Andrew
Prugar, Laura I.
Ruthel, Gordon
Lu, Jianhong
Liu, Yuliang
Liu, Wenbo
Liu, Xiaohong
Wrobel, Jay E.
Reitz, Allen B.
Dye, John M.
Harty, Ronald N.
Freedman, Bruce D.
TI Calcium Regulation of Hemorrhagic Fever Virus Budding: Mechanistic
Implications for Host-Oriented Therapeutic Intervention
SO PLoS Pathogens
LA English
DT Article
ID T-CELL-ACTIVATION; SMALL-MOLECULE INHIBITOR; ENDOPLASMIC-RETICULUM;
EBOLA-VIRUS; CA2+ INFLUX; PLASMA-MEMBRANE; PLAQUE-ASSAY; JUNIN VIRUS;
ANTIVIRAL ACTIVITY; IMMUNE-RESPONSES
AB Hemorrhagic fever viruses, including the filoviruses (Ebola and Marburg) and arenaviruses (Lassa and Junin viruses), are serious human pathogens for which there are currently no FDA approved therapeutics or vaccines. Importantly, transmission of these viruses, and specifically late steps of budding, critically depend upon host cell machinery. Consequently, strategies which target these mechanisms represent potential targets for broad spectrum host oriented therapeutics. An important cellular signal implicated previously in EBOV budding is calcium. Indeed, host cell calcium signals are increasingly being recognized to play a role in steps of entry, replication, and transmission for a range of viruses, but if and how filoviruses and arenaviruses mobilize calcium and the precise stage of virus transmission regulated by calcium have not been defined. Here we demonstrate that expression of matrix proteins from both filoviruses and arenaviruses triggers an increase in host cytoplasmic Ca2+ concentration by a mechanism that requires host Orai1 channels. Furthermore, we demonstrate that Orai1 regulates both VLP and infectious filovirus and arenavirus production and spread. Notably, suppression of the protein that triggers Orai activation (Stromal Interaction Molecule 1, STIM1) and genetic inactivation or pharmacological blockade of Orai1 channels inhibits VLP and infectious virus egress. These findings are highly significant as they expand our understanding of host mechanisms that may broadly control enveloped RNA virus budding, and they establish Orai and STIM1 as novel targets for broad-spectrum host-oriented therapeutics to combat these emerging BSL-4 pathogens and potentially other enveloped RNA viruses that bud via similar mechanisms.
C1 [Han, Ziying; Madara, Jonathan J.; Ruthel, Gordon; Lu, Jianhong; Liu, Yuliang; Liu, Wenbo; Liu, Xiaohong; Harty, Ronald N.; Freedman, Bruce D.] Univ Penn, Sch Vet Med, Dept Pathobiol, Philadelphia, PA 19104 USA.
[Herbert, Andrew; Prugar, Laura I.; Dye, John M.] US Army, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
[Wrobel, Jay E.; Reitz, Allen B.] Fox Chase Chem Div Ctr Inc, Doylestown, PA USA.
RP Han, ZY (reprint author), Univ Penn, Sch Vet Med, Dept Pathobiol, Philadelphia, PA 19104 USA.
EM rharty@vet.upenn.edu; bruce@vet.upenn.edu
FU National Institutes of Health [AI102104, U54-AI057168, AI060921];
Defense Threat Reduction Agency [CB3947]
FX RNH was supported in part by grants AI102104 and U54-AI057168 from the
National Institutes of Health. AH, LIP, and JMD were supported by the
Defense Threat Reduction Agency (CB3947). BDF was supported in part by
grant AI060921 from the National Institutes of Health. The funders had
no role in study design, data collection and analysis, decision to
publish, or preparation of the manuscript.
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PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1553-7366
EI 1553-7374
J9 PLOS PATHOG
JI PLoS Pathog.
PD OCT
PY 2015
VL 11
IS 10
AR e1005220
DI 10.1371/journal.ppat.1005220
PG 22
WC Microbiology; Parasitology; Virology
SC Microbiology; Parasitology; Virology
GA CV7OE
UT WOS:000364462700046
PM 26513362
ER
PT J
AU Hong, S
Biering, C
Sturm, TW
Yoon, KS
Gonzalez-Castro, JA
AF Hong, Seungho
Biering, Celio
Sturm, Terry W.
Yoon, Kwang Seok
Gonzalez-Castro, Juan A.
TI Effect of Submergence and Apron Length on Spillway Scour: Case Study
SO Water
LA English
DT Article
DE apron; riprap; scour; spillway; turbulence; velocity
ID HOLE DOWNSTREAM; FLOW; PERFORMANCE; JUMPS; JETS; WEIR
AB Large-scale water resources systems are often managed by an integrated set of hydraulic structures that are vulnerable to wider ranges of discharge and tailwater elevation than envisioned in their original design due to climate change and additional project objectives such as fostering healthy ecosystems. The present physical model study explored the performance of a spillway structure on the Kissimmee River, operated by the South Florida Water Management District, under extreme conditions of drought and flooding with accompanying low and high tailwater levels for both gate-controlled and uncontrolled spillway flow conditions. Maximum scour depths and their locations for two different riprap apron lengths downstream of the spillway stilling basin were measured along with the complex flow fields prior to scour. Effects of tailwater submergence, type of spillway flow and riprap apron length on scour results are interpreted in terms of the measured turbulent kinetic energy and velocity distributions near the bed.
C1 [Hong, Seungho] Univ Virginia, Dept Civil & Environm Engn, Morgantown, WV 26506 USA.
[Biering, Celio] US Mil Acad, Dept Civil & Mech Engn, West Point, NY 10996 USA.
[Sturm, Terry W.] Georgia Inst Technol, Dept Civil & Environm Engn, Atlanta, GA 30332 USA.
[Yoon, Kwang Seok] Korea Inst Civil Engn & Bldg Technol, Goyang 411712, South Korea.
[Gonzalez-Castro, Juan A.] South Florida Water Management Dist, W Palm Beach, FL 33406 USA.
RP Sturm, TW (reprint author), Georgia Inst Technol, Dept Civil & Environm Engn, Atlanta, GA 30332 USA.
EM sehong@mail.wvu.edu; Celio.Biering@usma.edu; tsturm@ce.gatech.edu;
ksyoon@kict.re.kr; jgonzal@sfwmd.gov
FU South Florida Water Management District; Korea Institute of Civil
Engineering and Building Technology
FX The South Florida Water Management District provided funding for
construction of the spillway model but for a different set of
experiments than reported herein. The Korea Institute of Civil
Engineering and Building Technology funded these experiments as part of
a broader study of core technologies in the field of river management
conducted at the Georgia Institute of Technology. These joint
contributions are gratefully acknowledged.
NR 23
TC 1
Z9 1
U1 2
U2 5
PU MDPI AG
PI BASEL
PA POSTFACH, CH-4005 BASEL, SWITZERLAND
SN 2073-4441
J9 WATER-SUI
JI Water
PD OCT
PY 2015
VL 7
IS 10
BP 5378
EP 5395
DI 10.3390/w7105378
PG 18
WC Water Resources
SC Water Resources
GA CV5LV
UT WOS:000364313100009
ER
PT J
AU Reiter, MJ
Hannemann, NP
Schwope, RB
Lisanti, CJ
Learn, PA
AF Reiter, Michael J.
Hannemann, Nathan P.
Schwope, Ryan B.
Lisanti, Christopher J.
Learn, Peter A.
TI Role of imaging for patients with colorectal hepatic metastases: what
the radiologist needs to know
SO ABDOMINAL IMAGING
LA English
DT Article
DE Colorectal cancer; Hepatic metastases; Portal vein embolization; CT; MRI
ID PORTAL-VEIN EMBOLIZATION; LIVER METASTASES; SURGICAL-MANAGEMENT; CANCER
METASTASES; PREOPERATIVE EVALUATION; EMISSION-TOMOGRAPHY; ENHANCED MRI;
CT FINDINGS; RESECTION; LESIONS
AB Surgical resection of colorectal metastatic disease has increased as surgeons have adopted a more aggressive ideology. Current exclusion criteria are patients for whom a negative resection margin is not feasible or a future liver remnant (FLR) of greater than 20% is not achievable. The goal of preoperative imaging is to identify the number and distribution of liver metastases, in addition to establishing their relation to relevant intrahepatic structures. FLR can be calculated utilizing cross-sectional imaging to select out patients at risk for hepatic dysfunction after resection. MRI, specifically with gadoxetic acid contrast, is currently the preferred modality for assessment of hepatic involvement for patients with newly diagnosed colorectal cancer, to include those who have undergone neoadjuvant chemotherapy. Employment of liver-directed therapies has recently expanded and they may provide an alternative to hepatectomy in order to obtain locoregional control in poor surgical candidates or convert patients with initially unresectable disease into surgical candidates.
C1 [Reiter, Michael J.] SUNY Stony Brook, Med Ctr, Dept Radiol, Stony Brook, NY 11794 USA.
[Hannemann, Nathan P.; Schwope, Ryan B.; Lisanti, Christopher J.] Brooke Army Med Ctr, Dept Radiol, San Antonio, TX USA.
[Schwope, Ryan B.; Lisanti, Christopher J.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
[Learn, Peter A.] Brooke Army Med Ctr, Dept Surg, San Antonio, TX USA.
RP Reiter, MJ (reprint author), SUNY Stony Brook, Med Ctr, Dept Radiol, HSC Level 4,Room 120 East Loop Rd, Stony Brook, NY 11794 USA.
EM mikereiter13@yahoo.com
NR 61
TC 0
Z9 0
U1 0
U2 4
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0942-8925
EI 1432-0509
J9 ABDOM IMAGING
JI Abdom. Imaging
PD OCT
PY 2015
VL 40
IS 8
BP 3029
EP 3042
DI 10.1007/s00261-015-0507-8
PG 14
WC Gastroenterology & Hepatology; Radiology, Nuclear Medicine & Medical
Imaging
SC Gastroenterology & Hepatology; Radiology, Nuclear Medicine & Medical
Imaging
GA CV0PD
UT WOS:000363952000010
PM 26194812
ER
PT J
AU Reiter, MJ
Schwope, RB
Lisanti, CJ
Banks, NB
AF Reiter, Michael J.
Schwope, Ryan B.
Lisanti, Christopher J.
Banks, Nancy B.
TI Can a T2 hyperintense rim sign differentiate uterine leiomyomas from
other solid adnexal masses?
SO ABDOMINAL IMAGING
LA English
DT Article
DE Leiomyoma; High T2 signal rim; Adnexal mass
ID MR-IMAGING FINDINGS; OVARIAN; DIAGNOSIS; FEATURES; IMAGES; ORIGIN
AB To investigate the incidence of high T2 signal rims surrounding leiomyomas, evaluate if a particular T2-weighted sequence is more effective in depicting this rim, and determine if this sign is useful in differentiating pedunculated leiomyomas from other solid adnexal masses.
In this retrospective study, two radiologists evaluated 233 T2 dark pelvic masses (223 uterine leiomyomas and 10 ovarian fibromas) in 60 women (mean age 47) on Magnetic resonance imaging for the presence of a high signal rim. Three different T2-weighted sequences were reviewed independently for uterine leiomyomas: half-Fourier acquisition single-shot turbo spin echo (HASTE), SPACE, and T2 with fat saturation (T2 FS). Only T2 FS images were available for 10 fibromas. A consensus review was conducted for discrepant cases. Statistical analyses were performed using Fisher's exact test, kappa test, and ANOVA
For 223 uterine leiomyomas, 23% (95% CI 17.8-28.9%) demonstrated a high T2 signal rim sign on T2 FS compared with 4.9% (95% CI 2.6-8.9%) for HASTE and 6.7% (95% CI 3.9-11.1%) for SPACE. The difference between the number of positive rims on T2 FS relative-HASTE and SPACE was statistically significant (p < 0.001). For ovarian fibromas, 40% (95% CI 16.9-68.8%) were classified positive for a rim sign.
A high T2 signal rim sign was present for up to 23% of uterine leiomyomas and the T2 FS sequence detected this rim sign most frequently. Up to 40% of ovarian fibromas can also have a T2 rim sign and, therefore, a solid adnexal mass with a T2 rim sign cannot be assumed to represent a pedunculated leiomyoma.
C1 [Reiter, Michael J.] SUNY Stony Brook, Med Ctr, Dept Radiol, Stony Brook, NY 11794 USA.
[Schwope, Ryan B.; Lisanti, Christopher J.] Brooke Army Med Ctr, Dept Radiol, San Antonio, TX USA.
[Banks, Nancy B.] Brooke Army Med Ctr, Dept Pathol, San Antonio, TX USA.
RP Reiter, MJ (reprint author), SUNY Stony Brook, Med Ctr, Dept Radiol, HSC Level 4,Room 120 East Loop Rd, Stony Brook, NY 11794 USA.
EM mikereiter13@yahoo.com
NR 13
TC 1
Z9 1
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0942-8925
EI 1432-0509
J9 ABDOM IMAGING
JI Abdom. Imaging
PD OCT
PY 2015
VL 40
IS 8
BP 3182
EP 3190
DI 10.1007/s00261-015-0510-0
PG 9
WC Gastroenterology & Hepatology; Radiology, Nuclear Medicine & Medical
Imaging
SC Gastroenterology & Hepatology; Radiology, Nuclear Medicine & Medical
Imaging
GA CV0PD
UT WOS:000363952000029
PM 26205993
ER
PT J
AU Hunninghake, J
Murray, B
Manibusan, PA
McNear, S
Gancayco, J
AF Hunninghake, John
Murray, Brian
Manibusan, Pedro A., Jr.
McNear, Scott
Gancayco, John
TI Acute Ischemic Colitis and Portal Vein Thrombosis in a Young Female
Smoker on an Oral Contraceptive
SO AMERICAN JOURNAL OF GASTROENTEROLOGY
LA English
DT Meeting Abstract
CT 80th Annual Scientific Meeting of the
American-College-of-Gastroenterology
CY OCT 16-21, 2015
CL Honolulu, HI
SP Amer Coll Gastroenterol
C1 [Hunninghake, John] US Air Force, San Antonio Mil Med Ctr, San Antonio, TX USA.
[Murray, Brian] San Antonio Mil Med Ctr, San Antonio, TX USA.
[Manibusan, Pedro A., Jr.] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA.
[McNear, Scott] San Antonio Mil Med Ctr, Jbsa Ft Sam Houston, TX USA.
[Gancayco, John] US Air Force, Jbsa Ft Sam Houston, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0002-9270
EI 1572-0241
J9 AM J GASTROENTEROL
JI Am. J. Gastroenterol.
PD OCT
PY 2015
VL 110
SU 1
MA 400
BP S173
EP S173
PG 1
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA CU7KO
UT WOS:000363715900401
ER
PT J
AU Manibusan, PA
Okoh, E
Palacios, R
AF Manibusan, Pedro A., Jr.
Okoh, Emuejevoke
Palacios, Raul
TI Y90 Treatment in Pregnant Woman With Fibrolamellar Hepatocellular
Carcinoma
SO AMERICAN JOURNAL OF GASTROENTEROLOGY
LA English
DT Meeting Abstract
CT 80th Annual Scientific Meeting of the
American-College-of-Gastroenterology
CY OCT 16-21, 2015
CL Honolulu, HI
SP Amer Coll Gastroenterol
C1 [Manibusan, Pedro A., Jr.; Palacios, Raul] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA.
[Okoh, Emuejevoke] SAUSHEC Dept Gastroenterol, San Antonio, TX USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0002-9270
EI 1572-0241
J9 AM J GASTROENTEROL
JI Am. J. Gastroenterol.
PD OCT
PY 2015
VL 110
SU 1
MA 775
BP S339
EP S339
PG 1
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA CU7KO
UT WOS:000363715901321
ER
PT J
AU Tritsch, A
Cebe, K
Womeldorph, C
AF Tritsch, Adam
Cebe, Katharine
Womeldorph, Craig
TI Giardiasis and Protein-Losing Enteropathy as the Presenting Signs for
Common Variable Immunodeficiency in an Adult Male
SO AMERICAN JOURNAL OF GASTROENTEROLOGY
LA English
DT Meeting Abstract
CT 80th Annual Scientific Meeting of the
American-College-of-Gastroenterology
CY OCT 16-21, 2015
CL Honolulu, HI
SP Amer Coll Gastroenterol
C1 [Tritsch, Adam; Cebe, Katharine] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA.
[Womeldorph, Craig] SAUSHEC Dept Gastroenterol, San Antonio, TX USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0002-9270
EI 1572-0241
J9 AM J GASTROENTEROL
JI Am. J. Gastroenterol.
PD OCT
PY 2015
VL 110
SU 1
MA 1123
BP S490
EP S491
PG 2
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA CU7KO
UT WOS:000363715902222
ER
PT J
AU Tritsch, A
Cochet, A
Womeldorph, C
AF Tritsch, Adam
Cochet, Anthony
Womeldorph, Craig
TI Colonic Ischemia in a High-Performance Aircraft Pilot
SO AMERICAN JOURNAL OF GASTROENTEROLOGY
LA English
DT Meeting Abstract
CT 80th Annual Scientific Meeting of the
American-College-of-Gastroenterology
CY OCT 16-21, 2015
CL Honolulu, HI
SP Amer Coll Gastroenterol
C1 [Tritsch, Adam] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA.
[Cochet, Anthony] Laughlin Air Force Base, Med Grp 47, Ft Sam Houston, TX USA.
[Womeldorph, Craig] SAUSHEC Dept Gastroenterol, San Antonio, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0002-9270
EI 1572-0241
J9 AM J GASTROENTEROL
JI Am. J. Gastroenterol.
PD OCT
PY 2015
VL 110
SU 1
MA 376
BP S162
EP S163
PG 2
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA CU7KO
UT WOS:000363715900377
ER
PT J
AU Wetstein, P
Wang, J
Thibault, G
Gagliano, R
Tabak, B
AF Wetstein, Paul
Wang, James
Thibault, Gregory
Gagliano, Ronald
Tabak, Benjamin
TI Novel Endoscopic Placement of an Over-The-Scope Clip (OTSC) for Closure
of a Recto-neobladder Fistula
SO AMERICAN JOURNAL OF GASTROENTEROLOGY
LA English
DT Meeting Abstract
CT 80th Annual Scientific Meeting of the
American-College-of-Gastroenterology
CY OCT 16-21, 2015
CL Honolulu, HI
SP Amer Coll Gastroenterol
C1 [Wetstein, Paul] Tripler Army Med Ctr, Ewa Beach, HI USA.
[Wang, James; Tabak, Benjamin] Tripler Army Med Ctr, Honolulu, HI 96859 USA.
[Thibault, Gregory] Tripler Army Med Ctr, Kailua, HI USA.
[Gagliano, Ronald] Univ Arizona, Ctr Canc DIgn Hlth, St Josephs Hosp & Med Ctr, Phoenix, AZ USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0002-9270
EI 1572-0241
J9 AM J GASTROENTEROL
JI Am. J. Gastroenterol.
PD OCT
PY 2015
VL 110
SU 1
MA 447
BP S191
EP S192
PG 2
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA CU7KO
UT WOS:000363715900448
ER
PT J
AU Ivler, CM
AF Ivler, Christina M.
TI Constrained State-Space Coupling Numerator Solution and Helicopter
External Load Control Design Application
SO JOURNAL OF GUIDANCE CONTROL AND DYNAMICS
LA English
DT Article
C1 US Army, Aeroflightdynam Directorate, Aviat Dev Directorate, Aviat & Missile Res Dev & Engn Ctr,Res Dev & Engn, Moffett Field, CA 94035 USA.
RP Ivler, CM (reprint author), US Army, Aeroflightdynam Directorate, Aviat Dev Directorate, Aviat & Missile Res Dev & Engn Ctr,Res Dev & Engn, Moffett Field, CA 94035 USA.
NR 9
TC 0
Z9 0
U1 0
U2 0
PU AMER INST AERONAUTICS ASTRONAUTICS
PI RESTON
PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091-4344 USA
SN 0731-5090
EI 1533-3884
J9 J GUID CONTROL DYNAM
JI J. Guid. Control Dyn.
PD OCT
PY 2015
VL 38
IS 10
BP 2004
EP +
DI 10.2514/1.G001093
PG 7
WC Engineering, Aerospace; Instruments & Instrumentation
SC Engineering; Instruments & Instrumentation
GA CV4KL
UT WOS:000364235600014
ER
PT J
AU Bixler, SL
Goff, AJ
AF Bixler, Sandra L.
Goff, Arthur J.
TI The Role of Cytokines and Chemokines in Filovirus Infection
SO VIRUSES-BASEL
LA English
DT Review
DE Filovirus; Ebola; Marburg; cytokine; chemokine; immunopathology
ID EBOLA-VIRUS-INFECTION; MARBURG HEMORRHAGIC-FEVER; I INTERFERON RESPONSE;
IMMUNE-RESPONSE; CYNOMOLGUS MACAQUES; GUINEA-PIGS; DENDRITIC CELLS;
ANGOLA INFECTION; RHESUS MACAQUES; MOUSE MODEL
AB Ebola- and marburgviruses are highly pathogenic filoviruses and causative agents of viral hemorrhagic fever. Filovirus disease is characterized by a dysregulated immune response, severe organ damage, and coagulation abnormalities. This includes modulation of cytokines, signaling mediators that regulate various components of the immune system as well as other biological processes. Here we examine the role of cytokines in filovirus infection, with an emphasis on understanding how these molecules affect development of the antiviral immune response and influence pathology. These proteins may present targets for immune modulation by therapeutic agents and vaccines in an effort to boost the natural immune response to infection and/or reduce immunopathology.
C1 [Bixler, Sandra L.; Goff, Arthur J.] United States Army, Med Res Inst Infect Dis, Frederick, MD 21702 USA.
RP Bixler, SL (reprint author), United States Army, Med Res Inst Infect Dis, 1425 Porter St, Frederick, MD 21702 USA.
EM sandra.l.bixler.ctr@mail.mil; arthur.j.goff.civ@mail.mil
FU Chemical and Biological Defense Research Associateship award from the
National Research Council of the National Academies; Defense Threat
Reduction Agency
FX We thank John Connor at Boston University, Steven Bradfute at the
University of New Mexico, and Sara Johnston at USAMRIID for critical
review of the manuscript. We also acknowledge John W. Braun of USAMRIID
for graphic design of the figures. S.B. is funded by a Chemical and
Biological Defense Research Associateship award from the National
Research Council of the National Academies and the Defense Threat
Reduction Agency.
NR 133
TC 1
Z9 1
U1 1
U2 10
PU MDPI AG
PI BASEL
PA POSTFACH, CH-4005 BASEL, SWITZERLAND
SN 1999-4915
J9 VIRUSES-BASEL
JI Viruses-Basel
PD OCT
PY 2015
VL 7
IS 10
BP 5489
EP 5507
DI 10.3390/v7102892
PG 19
WC Virology
SC Virology
GA CV4MW
UT WOS:000364242200020
PM 26512687
ER
PT J
AU Rand, BCC
Penn-Barwell, JG
Wenke, JC
AF Rand, B. C. C.
Penn-Barwell, J. G.
Wenke, J. C.
TI Combined local and systemic antibiotic delivery improves eradication of
wound contamination AN ANIMAL EXPERIMENTAL MODEL OF CONTAMINATED
FRACTURE
SO BONE & JOINT JOURNAL
LA English
DT Article
ID GENTAMICIN-COLLAGEN SPONGE; OPEN TIBIAL FRACTURES;
POLYMETHYLMETHACRYLATE BEADS; COMPOUND FRACTURES; PROPHYLACTIC USE;
INFECTION; MANAGEMENT; OUTCOMES; SURGERY; THERAPY
AB Systemic antibiotics reduce infection in open fractures. Local delivery of antibiotics can provide higher doses to wounds without toxic systemic effects. This study investigated the effect on infection of combining systemic with local antibiotics via polymethylmethacrylate (PMMA) beads or gel delivery.
An established Staphylococcus aureus contaminated fracture model in rats was used. Wounds were debrided and irrigated six hours after contamination and animals assigned to one of three groups, all of which received systemic antibiotics. One group had local delivery via antibiotic gel, another PMMA beads and the control group received no local antibiotics. After two weeks, bacterial levels were quantified.
Combined local and systemic antibiotics were superior to systemic antibiotics alone at reducing the quantity of bacteria recoverable from each group (p = 0.002 for gel; p = 0.032 for beads). There was no difference in the bacterial counts between bead and gel delivery (p = 0.62).
These results suggest that local antibiotics augment the antimicrobial effect of systemic antibiotics. Although no significant difference was found between vehicles, gel delivery offers technical advantages with its biodegradable nature, ability to conform to wound shape and to deliver increased doses. Further study is required to see if the gel delivery system has a clinical role.
C1 [Rand, B. C. C.; Penn-Barwell, J. G.] US Army Inst Surg Res, San Antonio, TX USA.
[Wenke, J. C.] US Army Inst Surg Res, Dept Extrem Trauma & Regenerat Med, San Antonio, TX USA.
RP Rand, BCC (reprint author), US Army Inst Surg Res, San Antonio, TX 78234 USA.
EM freeflyben@doctors.org.uk
NR 26
TC 1
Z9 2
U1 0
U2 1
PU BRITISH EDITORIAL SOC BONE JOINT SURGERY
PI LONDON
PA 22 BUCKINGHAM STREET, LONDON WC2N 6ET, ENGLAND
SN 2049-4394
J9 BONE JOINT J
JI Bone Joint J.
PD OCT
PY 2015
VL 97B
IS 10
BP 1423
EP 1427
PG 5
WC Orthopedics; Surgery
SC Orthopedics; Surgery
GA CU5VR
UT WOS:000363600600020
PM 26430020
ER
PT J
AU Brown, EP
Normandin, E
Osei-Owusu, NY
Mahan, AE
Chan, YN
Lai, JI
Vaccari, M
Rao, M
Franchini, G
Alter, G
Ackerman, ME
AF Brown, Eric P.
Normandin, Erica
Osei-Owusu, Nana Yaw
Mahan, Alison E.
Chan, Ying N.
Lai, Jennifer I.
Vaccari, Monica
Rao, Mangala
Franchini, Genoveffa
Alter, Galit
Ackerman, Margaret E.
TI Microscale purification of antigen-specific antibodies
SO JOURNAL OF IMMUNOLOGICAL METHODS
LA English
DT Article
DE Antigen; Antibody; Purification; Glycosylation; Effector function
ID IGG-FC; HIGH-THROUGHPUT; MONOCLONAL-ANTIBODY; IMMUNOGLOBULIN-G;
GLYCOSYLATION PROFILES; RHEUMATOID-ARTHRITIS; MASS-SPECTROMETRY;
EBOLA-VIRUS; SERUM IGG; IN-VIVO
AB Glycosylation of the Fc domain is an important driver of antibody effector function. While assessment of antibody glycoform compositions observed across total plasma IgG has identified differences associated with a variety of clinical conditions, in many cases it is the glycosylation state of only antibodies against a specific antigen or set of antigens that may be of interest, for example, in defining the potential effector function of antibodies produced during disease or after vaccination. Historically, glycoprofiling such antigen-specific antibodies in clinical samples has been challenging due to their low prevalence, the high sample requirement for most methods of glycan determination, and the lack of high-throughput purification methods. New methods of glycoprofiling with lower sample requirements and higher throughput have motivated the development of microscale and automatable methods for purification of antigen-specific antibodies from polyclonal sources such as clinical serum samples. In this work, we present a robot-compatible 96-well plate-based method for purification of antigen-specific antibodies, suitable for such population level glycosylation screening. We demonstrate the utility of this method across multiple antibody sources, using both purified plasma IgG and plasma, and across multiple different antigen types, with enrichment factors greater than 1000-fold observed. Using an on-column IdeS protease treatment, we further describe staged release of Fc and Fab domains, allowing for glycoprofiling of each domain. (C) 2015 Elsevier B.V. All rights reserved.
C1 [Brown, Eric P.; Normandin, Erica; Chan, Ying N.; Lai, Jennifer I.; Ackerman, Margaret E.] Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA.
[Osei-Owusu, Nana Yaw] Dartmouth Coll, Mol & Cellular Biol Program, Hanover, NH 03755 USA.
[Mahan, Alison E.; Alter, Galit] MIT, Ragon Inst MGH, Cambridge, MA 02139 USA.
[Mahan, Alison E.; Alter, Galit] Harvard Univ, Cambridge, MA 02139 USA.
[Vaccari, Monica; Franchini, Genoveffa] NCI, Anim Models & Vaccine Sect, Bethesda, MD 20814 USA.
[Rao, Mangala] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA.
RP Ackerman, ME (reprint author), 14 Engn Dr, Hanover, NH 03755 USA.
EM Margaret.e.ackerman@dartmouth.edu
OI Mahan, Alison/0000-0003-4284-8467; Brown, Eric/0000-0002-8438-6136
FU Bill and Melinda Gates Foundation [OPP1032817]; NIH [1R01AI102691,
5R01AIl080289-03]
FX These studies were conducted with support from the Bill and Melinda
Gates Foundation OPP1032817; NIH 1R01AI102691 and 5R01AIl080289-03. The
authors acknowledge E. Billings of MHRP for the design of the cyclic
peptide. The following reagent was obtained through the NIH AIDS Reagent
Program, Division of AIDS, NIAID, NIH: Catalog #3957, HIV-IG from NABI
and NHLBL The opinions herein are those of the authors and should not be
construed as official or representing the views of the U.S. Department
of Defense or the Department of the Army, or the U.S. National
Institutes of Health.
NR 59
TC 3
Z9 3
U1 1
U2 5
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0022-1759
EI 1872-7905
J9 J IMMUNOL METHODS
JI J. Immunol. Methods
PD OCT
PY 2015
VL 425
BP 27
EP 36
DI 10.1016/j.jim.2015.06.005
PG 10
WC Biochemical Research Methods; Immunology
SC Biochemistry & Molecular Biology; Immunology
GA CU8UM
UT WOS:000363819600004
PM 26078040
ER
PT J
AU Ananworanich, J
Barre-Sinoussi, F
AF Ananworanich, Jintanat
Barre-Sinoussi, Francoise
TI Is it time to abandon single intervention cure trials?
SO LANCET HIV
LA English
DT Editorial Material
ID HIV-1 REMISSION
C1 [Ananworanich, Jintanat] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA.
[Ananworanich, Jintanat] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA.
[Barre-Sinoussi, Francoise] Inst Pasteur, Paris, France.
RP Ananworanich, J (reprint author), Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA.
EM jananworanich@hivresearch.org
FU NIAID NIH HHS [5R01AI114236-02]
NR 12
TC 2
Z9 3
U1 0
U2 2
PU ELSEVIER INC
PI SAN DIEGO
PA 525 B STREET, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 2352-3018
J9 LANCET HIV
JI Lancet HIV
PD OCT
PY 2015
VL 2
IS 10
BP E410
EP E411
PG 2
WC Immunology; Infectious Diseases
SC Immunology; Infectious Diseases
GA CU8LL
UT WOS:000363794100006
PM 26423646
ER
PT J
AU Simmerman, RF
Zhu, T
Baker, DR
Wang, LJ
Mishra, SR
Lundgren, CA
Bruce, BD
AF Simmerman, Richard F.
Zhu, Tuo
Baker, David R.
Wang, Lijia
Mishra, Sanjay R.
Lundgren, Cynthia A.
Bruce, Barry D.
TI Engineering Photosystem I Complexes with Metal Oxide Binding Peptides
for Bioelectronic Applications
SO BIOCONJUGATE CHEMISTRY
LA English
DT Article
ID PROTEIN SECONDARY STRUCTURE; CIRCULAR-DICHROISM SPECTRA; SENSITIZED
SOLAR-CELLS; EXCHANGE MECHANISM; TIO2; FERREDOXIN
AB Conventional dye-sensitized solar cells comprise semi-conducting anodes sensitized with complex synthetic organometallic dyes, a platinum counter electrode, and a liquid electrolyte. This work focuses on replacing synthetic dyes with a naturally occurring biological pigment protein complex known as Photosystem I (PSI). Specifically, ZnO binding peptides (ZOBiP)-fused PSI subunits (ZOBiP PsaD and ZOBiP PsaE) and TiO2 binding peptides (TOBiP)-fused ferredoxin (TOBiP-Fd) have been produced recombinantly from Escherichia coli. The MOBiP-fused peptides have been characterized via western blotting, circular dichroism, MALDI-TOF, and cyclic voltammetry. ZOBiP PSI subunits have been used to replace wild-type PsaD and PsaE, and TOBiP Fd has been chemically cross-linked to the stromal hump of PSI. These MOBiP peptides and MOBiP PSI complexes have been produced and incubated with various metal oxide nanoparticles, showing increased binding when compared to that of wildtype PSI complexes.
C1 [Simmerman, Richard F.; Zhu, Tuo; Bruce, Barry D.] Univ Tennessee, Dept Biochem & Cellular & Mol Biol, Knoxville, TN 37919 USA.
[Baker, David R.; Lundgren, Cynthia A.] US Army, Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA.
[Wang, Lijia; Mishra, Sanjay R.] Univ Memphis, Dept Phys, Memphis, TN 38152 USA.
RP Bruce, BD (reprint author), Univ Tennessee, Dept Biochem & Cellular & Mol Biol, Knoxville, TN 37919 USA.
EM bbruce@utk.edu
FU TN-SCORE - NSF-EPSCoR [EPS-1004083]; UTK BCMB Department; Gibson Family
Foundation; National Science Foundation IGERT program [DGE-0801470];
Directors Strategic Initiative, "Understanding Photosystem I as a
Biomolecular Reactor for Energy Conversion" at the Army Research
Laboratory, Adelphi, MD [W911NF-11-2-0029]
FX B.D.B. and S.R.M. acknowledge support from TN-SCORE, a multidisciplinary
research program sponsored by NSF-EPSCoR (EPS-1004083). RF.S., T.Z., and
B.D.B. acknowledge support from the UTK BCMB Department and from the
Gibson Family Foundation. RF.S. was supported as an IGERT Fellow from
the National Science Foundation IGERT program (DGE-0801470). B.D.B,
D.R.B., and CAL. also acknowledge support from the Directors Strategic
Initiative, "Understanding Photosystem I as a Biomolecular Reactor for
Energy Conversion" at the Army Research Laboratory, Adelphi, MD (ARL
contract no. W911NF-11-2-0029). We would like to thank Dr. John Dunlap
for help with electron microscopy. We also appreciate the support and
feedback provided by Ridge Carter, Khoa Nguyen, and Kristen Holbrook
while conducting this research.
NR 26
TC 2
Z9 2
U1 1
U2 18
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1043-1802
J9 BIOCONJUGATE CHEM
JI Bioconjugate Chem.
PD OCT
PY 2015
VL 26
IS 10
BP 2097
EP 2105
DI 10.1021/acs.bioconjchem.5b00374
PG 9
WC Biochemical Research Methods; Biochemistry & Molecular Biology;
Chemistry, Multidisciplinary; Chemistry, Organic
SC Biochemistry & Molecular Biology; Chemistry
GA CU3PU
UT WOS:000363438100014
PM 26301489
ER
PT J
AU Adler, AB
Britt, TW
Riviere, LA
Kim, PY
Thomas, JL
AF Adler, Amy B.
Britt, Thomas W.
Riviere, Lyndon A.
Kim, Paul Y.
Thomas, Jeffrey L.
TI Longitudinal determinants of mental health treatment-seeking by US
soldiers
SO BRITISH JOURNAL OF PSYCHIATRY
LA English
DT Article
ID RANDOMIZED CONTROLLED-TRIAL; PERCEIVED STIGMA; ARMED-FORCES; IRAQ
RANDOMIZATION; CARE; BARRIERS; MILITARY; COMBAT; AFGHANISTAN; PERSONNEL
AB Background
Studies with members of the armed forces have found a gap between reports of mental health symptoms and treatment-seeking.
Aims
To assess the impact of attitudes on treatment-seeking behaviours in soldiers returning from a combat deployment.
Method
A sample of 529 US soldiers were surveyed 4 months (time 1) and 12 months (time 2) post-deployment. Mental health symptoms and treatment-seeking attitudes were assessed at time 1; reported mental healthcare visits were assessed at time 2.
Results
Factor analysis of the total time 1. sample revealed four attitude factors: professional concerns, practical barriers, preference for self-management and positive attitudes about treatment. For the subset of 160 soldiers reporting a mental health problem at time 1, and controlling for mental health symptom severity, self-management inversely predicted treatment-seeking; positive attitudes were positively related.
Conclusions
Results demonstrate the importance of broadening the conceptualisation of barriers and facilitators of mental healthcare beyond stigma. Techniques and delivery models emphasising self-care may help increase soldiers' interest in using mental health services.
C1 [Adler, Amy B.] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Mil Psychiat Branch, Silver Spring, MD 20910 USA.
[Britt, Thomas W.] Clemson Univ, Dept Psychol, Clemson, SC 29634 USA.
[Riviere, Lyndon A.; Kim, Paul Y.] Walter Reed Army Inst Res, Dept Mil Psychiat, Silver Spring, MD 20910 USA.
[Thomas, Jeffrey L.] Walter Reed Army Inst Res, US Army Med Res Unit Europe, Sembach Heuberg, Germany.
RP Adler, AB (reprint author), Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Mil Psychiat Branch, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
FU US Army Military Operational Medicine Research Program
FX Funding was received from the US Army Military Operational Medicine
Research Program. The views expressed in this article are those of the
authors and do not necessarily represent the official policy or position
of the US Army Medical Command or the US Army. The study was approved by
the Institutional Review Board at the Walter Reed Army Institute of
Research.
NR 37
TC 4
Z9 4
U1 0
U2 1
PU ROYAL COLLEGE OF PSYCHIATRISTS
PI LONDON
PA BRITISH JOURNAL OF PSYCHIATRY 17 BELGRAVE SQUARE, LONDON SW1X 8PG,
ENGLAND
SN 0007-1250
EI 1472-1465
J9 BRIT J PSYCHIAT
JI Br. J. Psychiatry
PD OCT
PY 2015
VL 207
IS 4
BP 346
EP 350
DI 10.1192/bjp.bp.114.146506
PG 5
WC Psychiatry
SC Psychiatry
GA CU0QF
UT WOS:000363222900015
PM 25858176
ER
PT J
AU Suri, N
Benincasa, G
Lenzi, R
Tortonesi, M
Stefanelli, C
Sadler, L
AF Suri, Niranjan
Benincasa, Giacomo
Lenzi, Rita
Tortonesi, Mauro
Stefanelli, Cesare
Sadler, Laurel
TI Exploring Value-of-Information-Based Approaches to Support Effective
Communications in Tactical Networks
SO IEEE COMMUNICATIONS MAGAZINE
LA English
DT Article
ID ENVIRONMENTS OBSERVATIONS; EXPERIENCES
AB Tactical networking environments present many challenges in terms of bandwidth, latency, reliability, stability, and connectivity. Sensors can today generate very large data sets that exceed the ability of tactical networks to transfer and disseminate them in a timely manner. Furthermore, the desire to cover larger areas with persistent sensing capabilities, have resulted in the widescale deployment of inexpensive sensors, further widening the gap between the volume of information that is generated and the subset that can successfully be delivered to consumers. This article explores the notion of determining the value of information in order to prioritize and filter information that is disseminated over these tactical networks, focusing on the dissemination of information to and from dismounted soldiers in a battlefield environment. This is a promising approach to mitigate the constraints of tactical networks and to reduce information overload on soldiers.
C1 [Suri, Niranjan] Florida Inst Human & Machine Cognit IHMC, Homestead, FL USA.
[Suri, Niranjan; Sadler, Laurel] US Army Res Lab, Adelphi, MD USA.
[Benincasa, Giacomo; Lenzi, Rita] IHMC, New York, NY USA.
[Tortonesi, Mauro; Stefanelli, Cesare] Univ Ferrara, I-44100 Ferrara, Italy.
RP Suri, N (reprint author), Florida Inst Human & Machine Cognit IHMC, Homestead, FL USA.
EM nsuri@ihmc.us; gbenincasa@ihmc.us; rlenzi@ihmc.us;
mauro.tortonesi@unife.it; cesare.stefanelli@unife.it;
laurel.c.sadler.civ@mail.mil
OI Benincasa, Giacomo/0000-0002-6357-9043
FU Office of Naval Research [N00014-09-1-0012]; U.S. Army Research
Laboratory [W911NF-11-2-0095]
FX The authors would like to thank John Moniz at the Office of Naval
Research for initial sponsorship under Grant N00014-09-1-0012, and the
U.S. Army Research Laboratory for continued sponsorship under
cooperative agreement W911NF-11-2-0095.
NR 13
TC 3
Z9 3
U1 1
U2 2
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 0163-6804
EI 1558-1896
J9 IEEE COMMUN MAG
JI IEEE Commun. Mag.
PD OCT
PY 2015
VL 53
IS 10
BP 39
EP 45
PG 7
WC Engineering, Electrical & Electronic; Telecommunications
SC Engineering; Telecommunications
GA CU0YU
UT WOS:000363246200005
ER
PT J
AU Harjani, R
Cabric, D
Markovic, D
Sadler, BM
Palani, RK
Saha, A
Shin, H
Rebeiz, E
Basir-Kazeruni, S
Yuan, FL
AF Harjani, Ramesh
Cabric, Danijela
Markovic, Dejan
Sadler, Brian M.
Palani, Rakesh K.
Saha, Anindya
Shin, Hundo
Rebeiz, Eric
Basir-Kazeruni, Sina
Yuan, Fang-Li
TI Wideband Blind Signal Classification on a Battery Budget
SO IEEE COMMUNICATIONS MAGAZINE
LA English
DT Article
ID AUTOMATIC MODULATION CLASSIFICATION
AB A wideband signal sensor is an essential component to enable cognitive radio and dynamic spectrum access techniques, providing real-time detection and modulation classification in a wideband environment of interest. The problem is challenging, requiring a processing suite incorporating detection, estimation, and classification, with stringent power objectives to enable widespread use in untethered battery powered devices. This article provides an overview of an integrated system-on-chip extremely low-power solution, including a wideband mixed-signal front-end, an algorithm suite that incorporates a blind hierarchical modulation classifier, and an ASIC implementation that employs dynamic voltage-frequency scaling and parallel processing that achieves measured energy efficiency ranging between 11.9 GOPS/mW and 13.6 GOPS/mW for full channel feature extraction, resulting in power consumption of 20.1 similar to 22.6 mW depending on the number of signals and signal bandwidth. The system bandwidth is selectable at 5, 50, and 500 MHz; in the 500 MHz case an efficient analog 8-point FFT channelizer relaxes the A/D requirement. The sensor can blindly detect and process up to 32 concurrent non-overlapping signals, with a variety of signal characteristics including single-vs. multi-carrier discrimination, carrier detection and estimation, and modulation classification.
C1 [Harjani, Ramesh] Univ Minnesota, Dept Elect & Comp Engn, Minneapolis, MN 55455 USA.
[Palani, Rakesh K.] Univ Minnesota, Elect Engn, St Paul, MN USA.
[Saha, Anindya] Univ Minnesota, Minneapolis, MN 55455 USA.
[Shin, Hundo] Univ Minnesota, St Paul, MN USA.
[Cabric, Danijela; Basir-Kazeruni, Sina] Univ Calif Los Angeles, Dept Elect Engn, Los Angeles, CA 90024 USA.
[Markovic, Dejan; Rebeiz, Eric; Yuan, Fang-Li] Univ Calif Los Angeles, Elect Engn, Los Angeles, CA 90024 USA.
[Markovic, Dejan] Univ Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90024 USA.
[Sadler, Brian M.] Army Res Lab, Adelphi, MD USA.
RP Harjani, R (reprint author), Univ Minnesota, Dept Elect & Comp Engn, Minneapolis, MN 55455 USA.
NR 14
TC 0
Z9 0
U1 3
U2 7
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 0163-6804
EI 1558-1896
J9 IEEE COMMUN MAG
JI IEEE Commun. Mag.
PD OCT
PY 2015
VL 53
IS 10
BP 173
EP 181
PG 9
WC Engineering, Electrical & Electronic; Telecommunications
SC Engineering; Telecommunications
GA CU0YU
UT WOS:000363246200025
ER
PT J
AU Christianson, MS
Shoham, G
Tobler, KJ
Zhao, YL
Cordeiro, CN
Leong, M
Shoham, Z
AF Christianson, Mindy S.
Shoham, Gon
Tobler, Kyle J.
Zhao, Yulian
Cordeiro, Christina N.
Leong, Milton
Shoham, Zeev
TI Measurement of antral follicle count in patients undergoing in vitro
fertilization treatment: results of a worldwide web-based survey
SO JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
LA English
DT Article
DE Antral follicle count; Ovarian reserve; In vitro fertilization
ID OVARIAN RESERVE TESTS; ANTIMULLERIAN HORMONE; IVF; PREDICTION; CYCLES;
NUMBER; DISAPPEARANCE; STIMULATION; POPULATION; DETERMINES
AB The purpose of the present study was to identify trends in the therapeutic approaches used to measure antral follicle count (AFC) in patients undergoing in vitro fertilization (IVF) treatment worldwide.
A retrospective evaluation utilizing the results of a web-based survey, IVF-Worldwide , was performed.
Responses from 796 centers representing 593,200 cycles were evaluated. The majority of respondents (71.2 %) considered antral follicle count as a mandatory part of their practice with most (69.0 %) measuring AFC in the follicular phase. Most respondents (89.7 %) reported that they would modify the IVF stimulation protocol based on the AFC. There was considerable variation regarding a limit for the number of antral follicles required to initiate an IVF cycle with 46.1 % designating three antral follicles as their limit, 39.9 % selecting either four or five follicles as their limit, and 14.0 % reporting a higher cutoff criteria. With respect to antral follicle size, 61.5 % included follicles ranging between 2 and 10 mm in the AFC. When asked to identify the best predictor of ovarian hyper-response during IVF cycles, AFC was selected most frequently (49.4 %), followed by anti-Mullerian hormone level (42.7 %). Age was selected as the best predictor of ongoing pregnancy rate in 81.7 % of respondents.
While a large proportion of respondents utilized AFC as part of their daily practice and modified IVF protocol based on the measurement, the majority did not consider AFC as the best predictor of ongoing pregnancy rate.
C1 [Christianson, Mindy S.; Zhao, Yulian] Johns Hopkins Univ, Sch Med, Dept Gynecol & Obstet, Div Reprod Endocrinol, Baltimore, MD 21205 USA.
[Shoham, Gon] Tel Aviv Univ, Sackler Sch Med, IL-69978 Tel Aviv, Israel.
[Tobler, Kyle J.] Womack Army Med Ctr, Dept Obstet & Gynecol, Div Reprod Endocrinol & Infertil, Ft Bragg, NC USA.
[Cordeiro, Christina N.] Johns Hopkins Univ, Sch Med, Dept Gynecol & Obstet, Baltimore, MD 21205 USA.
[Leong, Milton] Womens Clin, Hong Kong, Hong Kong, Peoples R China.
[Shoham, Zeev] Kaplan Med Ctr, Dept Obstet & Gynecol, IL-76100 Rehovot, Israel.
RP Christianson, MS (reprint author), Johns Hopkins Univ, Sch Med, Dept Gynecol & Obstet, Div Reprod Endocrinol, Baltimore, MD 21205 USA.
EM mchris21@jhmi.edu
NR 23
TC 1
Z9 1
U1 1
U2 1
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1058-0468
EI 1573-7330
J9 J ASSIST REPROD GEN
JI J. Assist. Reprod. Genet.
PD OCT
PY 2015
VL 32
IS 10
BP 1435
EP 1440
DI 10.1007/s10815-015-0555-6
PG 6
WC Genetics & Heredity; Obstetrics & Gynecology; Reproductive Biology
SC Genetics & Heredity; Obstetrics & Gynecology; Reproductive Biology
GA CU1HZ
UT WOS:000363272800002
PM 26341095
ER
PT J
AU Tobler, KJ
Shoham, G
Christianson, MS
Zhao, YL
Leong, M
Shoham, Z
AF Tobler, Kyle J.
Shoham, Gon
Christianson, Mindy S.
Zhao, Yulian
Leong, Milton
Shoham, Zeev
TI Use of anti-mullerian hormone for testing ovarian reserve: a survey of
796 infertility clinics worldwide
SO JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
LA English
DT Article
DE Anti-mullerian hormone; Survey; IVF-Worldwide; Ovarian reserve; IVF
ID IN-VITRO FERTILIZATION; FOLLICLE-STIMULATING-HORMONE; ANTIMULLERIAN
HORMONE; INHIBITING SUBSTANCE; TECHNOLOGY ART; LIVE BIRTH; IVF;
PREDICTION; FSH; METAANALYSIS
AB The aim of this study is to assess how anti-mullerian hormone (AMH) is used worldwide to test ovarian reserve and guide in vitro fertilization (IVF) cycle management.
An internet-based survey was sent electronically to registered IVF providers within the IVF-Worldwide.com network. This survey consisted of nine questions which assessed the clinics' use of AMH. The questionnaire was completed online through the IVF-Worldwide.com website, and quality assurance tools were used to verify that only one survey was completed per clinical IVF center. Results are reported as the proportion of IVF cycles represented by a particular answer choice.
Survey responses were completed from 796 globally distributed IVF clinics, representing 593,200 IVF cycles worldwide. Sixty percent of the respondent-IVF cycles reported to use AMH as a first line test, and 54 % reported it as the best test for evaluating ovarian reserve. Eighty-nine percent reported that AMH results were extremely relevant or relevant to clinical practice. However in contrast, for predicting live birth rate, 81 % reported age as the best predictor.
AMH is currently considered a first line test for evaluating ovarian reserve and is considered relevant to clinical practice by the majority of IVF providers.
C1 [Tobler, Kyle J.] Womack Army Med Ctr, Dept Obstet & Gynecol, Div Reprod Endocrinol & Infertil, Ft Bragg, NC 28307 USA.
[Shoham, Gon] Tel Aviv Univ, Sackler Sch Med, IL-69978 Tel Aviv, Israel.
[Christianson, Mindy S.; Zhao, Yulian] Johns Hopkins Univ, Sch Med, Dept Gynecol & Obstet, Div Reprod Endocrinol & Infertil, Baltimore, MD 21205 USA.
[Leong, Milton] Womens Clin, Hong Kong, Hong Kong, Peoples R China.
[Shoham, Zeev] Kaplan Med Ctr, Dept Obstet & Gynaecol, Rehovot, Israel.
[Shoham, Zeev] Hebrew Univ Jerusalem, Hadassah Med Sch, IL-91010 Jerusalem, Israel.
RP Tobler, KJ (reprint author), Womack Army Med Ctr, Dept Obstet & Gynecol, Div Reprod Endocrinol & Infertil, Ft Bragg, NC 28307 USA.
EM kyle.tobler@gmail.com
NR 32
TC 1
Z9 2
U1 0
U2 3
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1058-0468
EI 1573-7330
J9 J ASSIST REPROD GEN
JI J. Assist. Reprod. Genet.
PD OCT
PY 2015
VL 32
IS 10
BP 1441
EP 1448
DI 10.1007/s10815-015-0562-7
PG 8
WC Genetics & Heredity; Obstetrics & Gynecology; Reproductive Biology
SC Genetics & Heredity; Obstetrics & Gynecology; Reproductive Biology
GA CU1HZ
UT WOS:000363272800003
PM 26347341
ER
PT J
AU Basu, A
Mills, DM
Mitchell, D
Ndungo, E
Williams, JD
Herbert, AS
Dye, JM
Moir, DT
Chandran, K
Patterson, JL
Rong, LJ
Bowlin, TL
AF Basu, Arnab
Mills, Debra M.
Mitchell, Daniel
Ndungo, Esther
Williams, John D.
Herbert, Andrew S.
Dye, John M.
Moir, Donald T.
Chandran, Kartik
Patterson, Jean L.
Rong, Lijun
Bowlin, Terry L.
TI Novel Small Molecule Entry Inhibitors of Ebola Virus
SO JOURNAL OF INFECTIOUS DISEASES
LA English
DT Article
DE Ebola virus; Niemann-Pick C1; Ebola envelope glycoprotein; antiviral
ID NIEMANN-PICK C1; INFECTION; GLYCOPROTEIN; CHOLESTEROL; REQUIRES; NPC1
AB Background. The current Ebola virus (EBOV) outbreak has highlighted the troubling absence of available antivirals or vaccines to treat infected patients and stop the spread of EBOV. The EBOV glycoprotein (GP) plays critical roles in the early stage of virus infection, including receptor binding and membrane fusion, making it a potential target for the development of anti-EBOV drugs. We report the identification of 2 novel EBOV inhibitors targeting viral entry.
Methods. To identify small molecule inhibitors of EBOV entry, we carried out a cell-based high-throughput screening using human immunodeficiency virus-based pseudotyped viruses expressing EBOV-GP. Two compounds were identified, and mechanism-of-action studies were performed using immunoflourescence, AlphaLISA, and enzymatic assays for cathepsin B inhibition.
Results. We report the identification of 2 novel entry inhibitors. These inhibitors (1) inhibit EBOV infection (50% inhibitory concentration, approximately 0.28 and approximately 10 mu mol/L) at a late stage of entry, (2) induce Niemann-Pick C phenotype, and (3) inhibit GP-Niemann-Pick C1 (NPC1) protein interaction.
Conclusions. We have identified 2 novel EBOV inhibitors, MBX2254 and MBX2270, that can serve as starting points for the development of an anti-EBOV therapeutic agent. Our findings also highlight the importance of NPC1-GP interaction in EBOV entry and the attractiveness of NPC1 as an antifiloviral therapeutic target.
C1 [Basu, Arnab; Mills, Debra M.; Williams, John D.; Moir, Donald T.; Bowlin, Terry L.] Microbiotix Inc, Worcester, MA 01605 USA.
[Mitchell, Daniel; Patterson, Jean L.] Texas Biomed Res Inst, San Antonio, TX USA.
[Ndungo, Esther; Chandran, Kartik] Albert Einstein Coll Med, Bronx, NY 10467 USA.
[Herbert, Andrew S.; Dye, John M.] US Army, Med Res Inst Infect Dis, Frederick, MD USA.
[Rong, Lijun] Univ Illinois, Coll Med, Dept Microbiol & Immunol, Chicago, IL 60612 USA.
RP Basu, A (reprint author), Microbiotix Inc, 1 Innovat Dr, Worcester, MA 01605 USA.
EM abasu@microbiotix.com
OI Ndungo, Esther/0000-0002-9975-7032
FU National Institutes of Health [1R01AI089590, R01AI101436]
FX This work was supported by the National Institutes of Health (grants
1R01AI089590 and R01AI101436).
NR 23
TC 2
Z9 2
U1 5
U2 34
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0022-1899
EI 1537-6613
J9 J INFECT DIS
JI J. Infect. Dis.
PD OCT 1
PY 2015
VL 212
SU 2
BP S425
EP S434
DI 10.1093/infdis/jiv223
PG 10
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA CU0EP
UT WOS:000363189100047
PM 26206510
ER
PT J
AU Brannan, JM
Froude, JW
Prugar, LI
Bakken, RR
Zak, SE
Daye, SP
Wilhelmsen, CE
Dye, JM
AF Brannan, Jennifer M.
Froude, Jeffery W.
Prugar, Laura I.
Bakken, Russell R.
Zak, Samantha E.
Daye, Sharon P.
Wilhelmsen, Catherine E.
Dye, John M.
TI Interferon alpha/beta Receptor-Deficient Mice as a Model for Ebola Virus
Disease
SO JOURNAL OF INFECTIOUS DISEASES
LA English
DT Article
DE Ebola virus; Sudan virus; Ebola virus disease; mouse model;
pathogenesis; coagulopathy
ID T-CELL RESPONSES; HEMORRHAGIC-FEVER; MOUSE MODEL; GUINEA-PIGS;
INFECTION; PATHOGENESIS; SUDAN; FAVIPIRAVIR; PROTECTION; RESISTANCE
AB A major obstacle in ebolavirus research is the lack of a small-animal model for Sudan virus (SUDV), as well as other wild-type (WT) ebolaviruses. Here, we expand on research by Bray and by Lever et al suggesting that WT ebolaviruses are pathogenic in mice deficient for the type 1 interferon (IFN) alpha/beta receptor (IFN alpha/beta R-/-). We examined the disease course of several WT ebolaviruses: Boneface (SUDV/Bon) and Gulu variants of SUDV, Ebola virus (EBOV), Bundibugyo virus (BDBV), Tai Forest virus, and Reston virus (RESTV). We determined that exposure to WT SUDV or EBOV results in reproducible signs of disease in IFN alpha/beta R-/- mice, as measured by weight loss and partial lethality. Vaccination with the SUDV or EBOV glycoprotein (GP)-expressing Venezuelan equine encephalitis viral replicon particle vaccine protected these mice from SUDV/Bon and EBOV challenge, respectively. Treatment with SUDV-or EBOV-specific anti-GP antibodies protected mice from challenge when delivered 1-3 days after infection. Serial sampling experiments revealed evidence of disseminated intravascular coagulation in the livers of mice infected with the Boneface variant of SUDV, EBOV, and BDBV. Taken together, these data solidify the IFN alpha/beta R-/- mouse as an important and useful model for the study of WT EBOV disease.
C1 [Brannan, Jennifer M.; Froude, Jeffery W.; Prugar, Laura I.; Bakken, Russell R.; Zak, Samantha E.; Daye, Sharon P.; Wilhelmsen, Catherine E.; Dye, John M.] US Army Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
RP Dye, JM (reprint author), US Army Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA.
EM john.m.dye1.civ@mail.mil
FU Defense Threat Reduction Agency [FY12-13 DTRA/JSTO SEED]
FX This work was supported by the Defense Threat Reduction Agency (FY12-13
DTRA/JSTO SEED; Dr William Florence and Dr Erin Reichert).
NR 42
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Z9 12
U1 3
U2 13
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0022-1899
EI 1537-6613
J9 J INFECT DIS
JI J. Infect. Dis.
PD OCT 1
PY 2015
VL 212
SU 2
BP S282
EP S294
DI 10.1093/infdis/jiv215
PG 13
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA CU0EP
UT WOS:000363189100028
PM 25943199
ER
PT J
AU Willet, M
Kurup, D
Papaneri, A
Wirblich, C
Hooper, JW
Kwilas, SA
Keshwara, R
Hudacek, A
Beilfuss, S
Rudolph, G
Pommerening, E
Vos, A
Neubert, A
Jahrling, P
Blaney, JE
Johnson, RF
Schnell, MJ
AF Willet, Mallory
Kurup, Drishya
Papaneri, Amy
Wirblich, Christoph
Hooper, Jay W.
Kwilas, Steve A.
Keshwara, Rohan
Hudacek, Andrew
Beilfuss, Stefanie
Rudolph, Grit
Pommerening, Elke
Vos, Adriaan
Neubert, Andreas
Jahrling, Peter
Blaney, Joseph E.
Johnson, Reed F.
Schnell, Matthias J.
TI Preclinical Development of Inactivated Rabies Virus-Based Polyvalent
Vaccine Against Rabies and Filoviruses
SO JOURNAL OF INFECTIOUS DISEASES
LA English
DT Article
DE Ebola virus; Sudan virus; Marburg virus; rabies virus; vaccine;
filovirus; polyvalent vaccine
ID NEUTRALIZING ANTIBODY-RESPONSE; RHABDOVIRUS-BASED VECTORS;
NONHUMAN-PRIMATES; RESPIRATORY-TRACT; EBOLA VIRUSES; GLYCOPROTEIN;
CHALLENGE; HIV-1; LIVE; IMMUNIZATION
AB We previously described the generation of a novel Ebola virus (EBOV) vaccine based on inactivated rabies virus (RABV) containing EBOV glycoprotein (GP) incorporated in the RABV virion. Our results demonstrated safety, immunogenicity, and protective efficacy in mice and nonhuman primates (NHPs). Protection against viral challenge depended largely on the quality of the humoral immune response against EBOV GP.
Here we present the extension and improvement of this vaccine by increasing the amount of GP incorporation into virions via GP codon-optimization as well as the addition of Sudan virus (SUDV) and Marburg virus (MARV) GP containing virions. Immunogenicity studies in mice indicate similar immune responses for both SUDV GP and MARV GP compared to EBOV GP. Immunizing mice with multiple antigens resulted in immune responses similar to immunization with a single antigen. Moreover, immunization of NHP with the new inactivated RABV EBOV vaccine resulted in high titer neutralizing antibody levels and 100% protection against lethal EBOV challenge when applied with adjuvant.
Our results indicate that an inactivated polyvalent vaccine against RABV filoviruses is achievable. Finally, the novel vaccines are produced on approved VERO cells and a clinical grade RABV/EBOV vaccine for human trials has been produced.
C1 [Willet, Mallory; Kurup, Drishya; Wirblich, Christoph; Keshwara, Rohan; Hudacek, Andrew; Schnell, Matthias J.] Thomas Jefferson Univ, Dept Microbiol & Immunol, Philadelphia, PA 19107 USA.
[Schnell, Matthias J.] Thomas Jefferson Univ, Jefferson Med Coll, Jefferson Vaccine Ctr, Philadelphia, PA 19107 USA.
[Papaneri, Amy; Jahrling, Peter; Blaney, Joseph E.; Johnson, Reed F.] NIAID, Emerging Viral Pathogens Sect, NIH, Bethesda, MD 20892 USA.
[Hooper, Jay W.; Kwilas, Steve A.] NIAID, US Army, Med Res Inst Infect Dis, NIH, Ft Detrick, MD USA.
[Jahrling, Peter] NIAID, Integrated Res Facil, NIH, Ft Detrick, MD USA.
[Beilfuss, Stefanie; Rudolph, Grit; Pommerening, Elke; Vos, Adriaan; Neubert, Andreas] IDT Biol GmbH, Dessau Rosslau, Germany.
RP Schnell, MJ (reprint author), Thomas Jefferson Univ, Microbiol & Immunol, 233 S 10th St,BLSB,Ste 531, Philadelphia, PA 19107 USA.
EM matthias.schnell@jefferson.edu
OI Papaneri, Amy/0000-0003-2144-2441; Hooper, Jay/0000-0002-4475-0415
FU NIAID Divisions of Intramural Research and Clinical Research
[HHSN2722010000061, HHSN2722012000031, R01AI105204]; Jefferson Vaccine
Center
FX This work was supported in part by the NIAID Divisions of Intramural
Research and Clinical Research (contracts HHSN2722010000061 and
HHSN2722012000031 and grant R01AI105204 to M. J. S.) and the Jefferson
Vaccine Center.
NR 43
TC 8
Z9 8
U1 0
U2 9
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0022-1899
EI 1537-6613
J9 J INFECT DIS
JI J. Infect. Dis.
PD OCT 1
PY 2015
VL 212
SU 2
BP S414
EP S424
DI 10.1093/infdis/jiv251
PG 11
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA CU0EP
UT WOS:000363189100046
PM 26063224
ER
PT J
AU Shikuma, CM
Bennett, K
Ananworanich, J
Gerschenson, M
Teeratakulpisarn, N
Jadwattanakul, T
DeGruttola, V
McArthur, JC
Ebenezer, G
Chomchey, N
Praihirunkit, P
Hongchookiat, P
Mathajittiphun, P
Nakamoto, B
Hauer, P
Phanuphak, P
Phanuphak, N
AF Shikuma, Cecilia M.
Bennett, Kara
Ananworanich, Jintanat
Gerschenson, Mariana
Teeratakulpisarn, Nipat
Jadwattanakul, Tanate
DeGruttola, Victor
McArthur, Justin C.
Ebenezer, Gigi
Chomchey, Nitiya
Praihirunkit, Pairoa
Hongchookiat, Piranun
Mathajittiphun, Pornpen
Nakamoto, Beau
Hauer, Peter
Phanuphak, Praphan
Phanuphak, Nittaya
CA SEARCH 003 Protocol Team
TI Distal leg epidermal nerve fiber density as a surrogate marker of
HIV-associated sensory neuropathy risk: risk factors and change
following initial antiretroviral therapy
SO JOURNAL OF NEUROVIROLOGY
LA English
DT Article
DE HIV; Neuropathy; Epidermal nerve fiber density; Stavudine
ID PERIPHERAL NEUROPATHY; INFECTED ADULTS; SOUTH-AFRICA; STAVUDINE;
PARAMETERS; SAFETY; COHORT
AB Distal leg epidermal nerve fiber density (ENFD) is a validated predictor of HIV sensory neuropathy (SN) risk. We assessed how ENFD is impacted by initiation of first-time antiretroviral therapy (ART) in subjects free of neuropathy and how it is altered when mitochondrial toxic nucleoside medications are used as part of ART. Serial changes in proximal thigh and distal leg ENFD were examined over 72 weeks in 150 Thai subjects randomized to a regimen of stavudine (d4T) switching to zidovudine (ZDV) at 24 weeks vs ZDV vs tenofovir (TDF) for the entire duration of study, all given in combination with nevirapine. We found individual variations in ENFD change, with almost equal number of subjects who decreased or increased their distal leg ENFD over 72 weeks and no relationship to nucleoside backbone or to development of neuropathic signs or symptoms. Lower baseline distal leg ENFD and greater increases in mitochondrial oxidative phosphorylation complex I (CI) activity were associated with larger increases in distal leg ENFD over 72 weeks. Distal leg ENFD correlated with body composition parameters (body surface area, body mass index, height) as well as with blood pressure measurements. Assessed together with a companion cross-sectional study, we found that mean distal leg ENFD in all HIV+ subjects was lower than in HIV- subjects but similar among HIV+ groups whether ART-naive or on d4T with/without neuropathy/neuropathic symptoms. The utility of ENFD as a useful predictor of small unmyelinated nerve fiber damage and neuropathy risk in HIV may be limited in certain populations.
C1 [Shikuma, Cecilia M.; Gerschenson, Mariana; Nakamoto, Beau] Univ Hawaii, Honolulu, HI 96822 USA.
[Shikuma, Cecilia M.; Ananworanich, Jintanat; Chomchey, Nitiya; Praihirunkit, Pairoa; Phanuphak, Praphan; Phanuphak, Nittaya] South East Asia Res Collaborat Hawaii, Bangkok, Thailand.
[Bennett, Kara] Bennett Stat Consulting Inc, Ballston Lake, NY USA.
[Ananworanich, Jintanat] Walter Reed Army Inst Res, US Mil HIV Res Program, Bethesda, MD USA.
[Ananworanich, Jintanat] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA.
[Teeratakulpisarn, Nipat; Hongchookiat, Piranun; Phanuphak, Praphan; Phanuphak, Nittaya] Thai Red Cross AIDS Res Ctr, Bangkok, Thailand.
[Jadwattanakul, Tanate; Mathajittiphun, Pornpen] Queen Savang Vadhana Mem Hosp, Chon Buri, Thailand.
[DeGruttola, Victor] Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA.
[McArthur, Justin C.; Ebenezer, Gigi; Hauer, Peter] Johns Hopkins Sch Med, Baltimore, MD USA.
[Nakamoto, Beau] Straub Med Ctr, Honolulu, HI USA.
[Shikuma, Cecilia M.] Univ Hawaii Manoa, John A Burns Sch Med, Hawaii Ctr AIDS, Honolulu, HI 96813 USA.
RP Shikuma, CM (reprint author), Univ Hawaii, Honolulu, HI 96822 USA.
EM shikuma@hawaii.edu
FU Thai Government Pharmaceutical Organization; National Institute of
Health [R01NS063932, R01AI074554, P20RR011091 U54RR026136]; Gilead
Sciences; MitoSciences Inc. [P30MH075673, NS44807]
FX Thai Government Pharmaceutical Organization, National Institute of
Health R01NS063932 (CMS), R01AI074554 (MG), and P20RR011091 U54RR026136,
Gilead Sciences, MitoSciences Inc. P30MH075673 (JCM), and NS44807 (JCM).
NR 18
TC 1
Z9 1
U1 0
U2 2
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1355-0284
EI 1538-2443
J9 J NEUROVIROL
JI J. Neurovirol.
PD OCT
PY 2015
VL 21
IS 5
BP 525
EP 534
DI 10.1007/s13365-015-0352-0
PG 10
WC Neurosciences; Virology
SC Neurosciences & Neurology; Virology
GA CU0XO
UT WOS:000363242600007
PM 26002840
ER
PT J
AU DeNicolo, PJ
Guyton, MK
Cuenin, MF
Hokett, SD
Sharawy, M
Borke, J
McPherson, JC
AF DeNicolo, Philip J.
Guyton, M. Kelly
Cuenin, Michael F.
Hokett, Steven D.
Sharawy, Mohamed
Borke, James
McPherson, James C., III
TI Histologic Evaluation of Osseous Regeneration Following Combination
Therapy With Platelet-Rich Plasma and Bio-Oss in a Rat Calvarial
Critical-Size Defect Model
SO JOURNAL OF ORAL IMPLANTOLOGY
LA English
DT Article
DE bone regeneration; platelet-rich plasma; Bio-Oss
ID GUIDED BONE REGENERATION; HUMAN EXTRACTION SOCKETS; BOVINE BONE;
GROWTH-FACTORS; IMPLANTS; GRAFTS
AB Platelet-rich plasma (PRP) is an autogenous source of growth factors shown to facilitate human bone growth. Bio-Oss, an osteoconductive xenograft, is used clinically to regenerate periodontal defects, restore dental alveolar ridges, and facilitate sinus-lift procedures. The purpose of this study was to analyze whether a combination of PRP and Bio-Oss would enhance bone regeneration better than either material alone. PRP and/or Bio-Oss were administered in an 8-mm critical-size defect (CSD) rat calvarial model of bone defect between 2 polytetrafluoroethylene membranes to prevent soft tissue incursion. Eight weeks after the induction of the CSD, histologic sections were stained with hematoxylin and eosin stain and analyzed via light microscopy. Qualitative analyses revealed new bone regeneration in all 4 groups. The Bio-Oss and PRP plus Bio-Oss groups demonstrated greater areas of closure in the defects than the control or PRP-only groups because of the space-maintaining ability of Bio-Oss. The groups grafted with Bio-Oss showed close contact with new bone growth throughout the defects, suggesting a stronger graft. The use of PRP alone or in combination with Bio-Oss, however, did not appear to enhance osseous regeneration at 8 weeks. Areas grafted with Bio-Oss demonstrated greater space-maintaining capacity than controls, and PRP was an effective vehicle for placement of the Bio-Oss. However, at 8 weeks this study was unable to demonstrate a significant advantage of using PRP plus Bio-Oss over using Bio-Oss alone.
C1 [DeNicolo, Philip J.] US Army Dent Act Dent & Trauma Res Detachment, San Antonio, TX USA.
[Guyton, M. Kelly; McPherson, James C., III] DD Eisenhower Army Med Ctr, Dept Clin Invest, Ft Gordon, GA 30905 USA.
[Sharawy, Mohamed] Med Coll Georgia, Dept Oral Biol, Augusta, GA 30912 USA.
[Borke, James] Western Univ Hlth Sci, Coll Dent Med, Pomona, CA USA.
RP McPherson, JC (reprint author), DD Eisenhower Army Med Ctr, Dept Clin Invest, Ft Gordon, GA 30905 USA.
EM james.c.mcpherson4.civ@mail.mil
NR 31
TC 0
Z9 0
U1 0
U2 4
PU ALLEN PRESS INC
PI LAWRENCE
PA 810 E 10TH ST, LAWRENCE, KS 66044 USA
SN 0160-6972
EI 1548-1336
J9 J ORAL IMPLANTOL
JI J. Oral Implant.
PD OCT
PY 2015
VL 41
IS 5
BP 543
EP 549
DI 10.1563/AAID-JOI-D-12-00075
PG 7
WC Dentistry, Oral Surgery & Medicine
SC Dentistry, Oral Surgery & Medicine
GA CT8QR
UT WOS:000363081600006
PM 24003871
ER
PT J
AU Gentile, JA
AF Gentile, John A., Jr.
TI The History of NCCN and JNCCN
SO JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK
LA English
DT Biographical-Item
C1 [Gentile, John A., Jr.] Harborside Press, Cold Spring Harbor, NY 11724 USA.
[Gentile, John A., Jr.] US Army, New York, NY USA.
[Gentile, John A., Jr.] Int Med News Serv, Seattle, WA USA.
[Gentile, John A., Jr.] PRR Inc, Seattle, WA USA.
[Gentile, John A., Jr.] US Med, New York, NY USA.
RP Gentile, JA (reprint author), Harborside Press, Cold Spring Harbor, NY 11724 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU HARBORSIDE PRESS
PI COLD SPRING HARBOR
PA 37 MAIN ST, COLD SPRING HARBOR, NY 11724 USA
SN 1540-1405
EI 1540-1413
J9 J NATL COMPR CANC NE
JI J. Natl. Compr. Cancer Netw.
PD OCT
PY 2015
VL 13
IS 10
BP 1173
EP 1174
PG 2
WC Oncology
SC Oncology
GA CU3OF
UT WOS:000363434000003
PM 26483057
ER
PT J
AU Birt, AM
Champagne, VK
Sisson, RD
Apelian, D
AF Birt, A. M.
Champagne, V. K., Jr.
Sisson, R. D., Jr.
Apelian, D.
TI Microstructural Analysis of Cold-Sprayed Ti-6Al-4V at the Micro- and
Nano-Scale
SO JOURNAL OF THERMAL SPRAY TECHNOLOGY
LA English
DT Article
DE cold spray; microstructure; morphology; Ti-6Al-4V; transformation
ID MECHANICAL-PROPERTIES; TITANIUM; DEPOSITION; BEHAVIOR; COATINGS
AB The microstructure of cold-sprayed Ti-6Al-4V is unlike the structure resulting from any other processing technique. The unique characteristics are derived from the solid state thermomechanical processing of predominantly martensitic feedstock powders. During deposition, these powders undergo high strain rate deformation, leading to shear band-induced transformation of martensitic grains into nano-scale martensite, equiaxed alpha structures, and nanostructured alpha grains. The resultant microstructure evolution is dependent on the magnitude and direction of shear undergone by the particles. The specific structure and mechanism for formation of these regions will be discussed in detail using nanohardness mapping, scanning electron microscopy, and transmission electron microscopy.
C1 [Birt, A. M.; Sisson, R. D., Jr.; Apelian, D.] Worcester Polytech Inst, Met Proc Inst, Worcester, MA 01609 USA.
[Champagne, V. K., Jr.] US Army, Res Lab, Aberdeen Proving Ground, MD USA.
RP Birt, AM (reprint author), Worcester Polytech Inst, Met Proc Inst, 100 Inst Rd,Washburn Shops Off 315, Worcester, MA 01609 USA.
EM ambirt@wpi.edu
FU U.S. Army Research Laboratory [W911NF-10-2-0098]
FX Special thanks to U.S. Army Research Laboratory Contract #:
W911NF-10-2-0098 for sponsoring and directing this research, as well as
taking the time to consult and produce samples.
NR 36
TC 2
Z9 2
U1 5
U2 11
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1059-9630
EI 1544-1016
J9 J THERM SPRAY TECHN
JI J. Therm. Spray Technol.
PD OCT
PY 2015
VL 24
IS 7
BP 1277
EP 1288
DI 10.1007/s11666-015-0288-1
PG 12
WC Materials Science, Coatings & Films
SC Materials Science
GA CT8AZ
UT WOS:000363038600016
ER
PT J
AU Dowben, JS
Kowalski, PC
Keltner, NL
AF Dowben, Jonathan S.
Kowalski, Peter C.
Keltner, Norman L.
TI Biological Perspectives Anti-NMDA Receptor Encephalitis
SO PERSPECTIVES IN PSYCHIATRIC CARE
LA English
DT Article
DE Encephalitis; glutamate; NMDA receptors
AB PurposeThis article explores the recently recognized anti-NMDA receptor encephalitis, which may produce psychiatric symptoms.
ConclusionsHistorically, some patients presenting for psychiatric care may have actually been suffering from anti-NMDA encephalitis; thus, awareness of this disorder may facilitate appropriate treatment.
Treatment ImplicationsEarly diagnosis and aggressive treatment promote better outcomes. First-line treatment includes immunotherapy.
C1 [Dowben, Jonathan S.] Brooke Army Med Ctr, Child & Family Behav Hlth Serv, Ft Sam Houston, TX 78234 USA.
[Keltner, Norman L.] Univ Alabama Birmingham, Sch Nursing, Birmingham, AL 35487 USA.
RP Dowben, JS (reprint author), Brooke Army Med Ctr, Child & Family Behav Hlth Serv, Ft Sam Houston, TX 78234 USA.
EM normankeltner@gmail.com
NR 7
TC 2
Z9 2
U1 0
U2 8
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0031-5990
EI 1744-6163
J9 PERSPECT PSYCHIATR C
JI Perspect. Psychiatr. Care
PD OCT
PY 2015
VL 51
IS 4
BP 236
EP 240
DI 10.1111/ppc.12132
PG 5
WC Nursing; Psychiatry
SC Nursing; Psychiatry
GA CU4AX
UT WOS:000363469500003
PM 26220456
ER
PT J
AU He, BD
Stepanov, V
Qiu, HW
Krasnoperov, LN
AF He, Beidi
Stepanov, Victor
Qiu, Hongwei
Krasnoperov, Lev N.
TI Production and Characterization of Composite Nano-RDX by RESS
Co-Precipitation
SO PROPELLANTS EXPLOSIVES PYROTECHNICS
LA English
DT Article
DE Nanoparticles; Core-shell; RDX; Supercritical solutions; Carbon dioxide
ID RAPID EXPANSION; SUPERCRITICAL SOLUTIONS; NANOCRYSTALLINE RDX; FINE
PARTICLES; ENCAPSULATION; ANTISOLVENT; POLYMER; PRECIPITATION;
MICROSPHERES
AB Nanoscale composites of hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) and polymeric binders were produced by co-precipitation using rapid expansion of supercritical solutions (RESS). The binders used in this study are poly (vinylidene fluoride-co-hexafluoropropylene) (VDF-HFP22) and polystyrene (PS). The RDX/VDF-HFP22 and RDX/PS co-precipitated nanoparticles were characterized by Scanning Electron Microscopy (SEM) and Transmission Electron Microscopy (TEM). The average size of produced nanoparticles is ca. 100 nm. TEM analysis of RDX/PS nanocomposite shows a core-shell structure with RDX as the core material and the shell consisting of the polymeric binder. X-ray Powder Diffraction (XRPD) analysis indicates polycrystalline structure of RDX in the product with a crystallite size of 42 nm. The content of RDX in the composite particles is in the range of 70-73% by mass as determined by Gas Chromatography Mass Spectroscopy (GCMS) and by XRPD.
C1 [He, Beidi; Krasnoperov, Lev N.] New Jersey Inst Technol, Dept Chem & Environm Sci, Newark, NJ 07102 USA.
[Stepanov, Victor] US Army, RDECOM ARDEC, Armaments Engn Technol Ctr, Picatinny Arsenal, NJ 07806 USA.
[Qiu, Hongwei] Leidos Inc, Engn & Technol Solut Div, Picatinny Arsenal, NJ 07806 USA.
RP He, BD (reprint author), New Jersey Inst Technol, Dept Chem & Environm Sci, Newark, NJ 07102 USA.
EM krasnoperov@adm.njit.edu
NR 21
TC 3
Z9 3
U1 2
U2 10
PU WILEY-V C H VERLAG GMBH
PI WEINHEIM
PA POSTFACH 101161, 69451 WEINHEIM, GERMANY
SN 0721-3115
EI 1521-4087
J9 PROPELL EXPLOS PYROT
JI Propellants Explos. Pyrotech.
PD OCT
PY 2015
VL 40
IS 5
BP 659
EP 664
DI 10.1002/prep.201400249
PG 6
WC Chemistry, Applied; Engineering, Chemical
SC Chemistry; Engineering
GA CU2FH
UT WOS:000363338500006
ER
PT J
AU Gottfried, JL
AF Gottfried, Jennifer L.
TI Laboratory-Scale Method for Estimating Explosive Performance from
Laser-Induced Shock Waves
SO PROPELLANTS EXPLOSIVES PYROTECHNICS
LA English
DT Article
DE Laboratory-scale testing; Laser-induced shock wave; Detonation velocity;
Explosive performance; Blast propagation
ID INDUCED BREAKDOWN SPECTROSCOPY; TEMPERATURE; EXPANSION; ABLATION; GAS;
RDX
AB A new laboratory-scale method for predicting explosive performance (e.g., detonation velocity and pressure) based on milligram quantities of material is demonstrated. This technique is based on schlieren imaging of the shock wave generated in air by the formation of a laser-induced plasma on the surface of an energetic material residue. The shock wave from each laser ablation event is tracked for more than 100 mu s using a high-speed camera. A suite of conventional energetic materials including DNAN, TNT, HNS, TATB, NTO, PETN, RDX, HMX, and CL-20 was used to develop calibration curves relating the characteristic shock velocity for each energetic material to several detonation parameters. A strong linear correlation between the laser-induced shock velocity and the measured performance from full-scale detonation testing has been observed. The Laser-induced Air Shock from Energetic Materials (LASEM) method was validated using nitrocellulose, FOX-7, nano-RDX, three military formulations, and three novel high-nitrogen explosives currently under development. This method is a potential screening tool for the development of new energetic materials and formulations prior to larger-scale detonative testing. The main advantages are the small quantity of material required (a few milligrams or less per laser shot), the ease with which hundreds of measurements per day can be obtained, and the ability to estimate explosive performance without detonating the material (reducing cost and safety requirements).
C1 US Army Res Lab, RDRL WML B, Aberdeen Proving Ground, MD 21005 USA.
RP Gottfried, JL (reprint author), US Army Res Lab, RDRL WML B, Aberdeen Proving Ground, MD 21005 USA.
EM jennifer.l.gottfried.civ@mail.mil
NR 35
TC 3
Z9 3
U1 7
U2 31
PU WILEY-V C H VERLAG GMBH
PI WEINHEIM
PA POSTFACH 101161, 69451 WEINHEIM, GERMANY
SN 0721-3115
EI 1521-4087
J9 PROPELL EXPLOS PYROT
JI Propellants Explos. Pyrotech.
PD OCT
PY 2015
VL 40
IS 5
BP 674
EP 681
DI 10.1002/prep.201400302
PG 8
WC Chemistry, Applied; Engineering, Chemical
SC Chemistry; Engineering
GA CU2FH
UT WOS:000363338500008
ER
PT J
AU Camacho, M
Robertson, M
Abdullatif, J
Certal, V
Kram, YA
Ruoff, CM
Brietzke, SE
Capasso, R
AF Camacho, M.
Robertson, M.
Abdullatif, J.
Certal, V.
Kram, Y. A.
Ruoff, C. M.
Brietzke, S. E.
Capasso, R.
TI Smartphone apps for snoring
SO JOURNAL OF LARYNGOLOGY AND OTOLOGY
LA English
DT Article
DE Smartphone; Mobile Apps; Snoring; Respiratory Sounds; Treatment
ID OBSTRUCTIVE SLEEP-APNEA; METAANALYSIS
AB Objective: To identify and systematically evaluate user-friendly smartphone snoring apps.
Methods: The Apple iTunes app store was searched for snoring apps that allow recording and playback. Snoring apps were downloaded, evaluated and rated independently by four authors. Two patients underwent polysomnography, and the data were compared with simultaneous snoring app recordings, and one patient used the snoring app at home.
Results: Of 126 snoring apps, 13 met the inclusion and exclusion criteria. The most critical app feature was the ability to graphically display the snoring events. The Quit Snoring app received the highest overall rating. When this app's recordings were compared with in-laboratory polysomnography data, app snoring sensitivities ranged from 64 to 96 per cent, and snoring positive predictive values ranged from 93 to 96 per cent. A chronic snorer used the app nightly for one month and tracked medical interventions. Snoring decreased from 200 to 10 snores per hour, and bed partner snoring complaint scores decreased from 9 to 2 (on a 0-10 scale).
Conclusion: Select smartphone apps are user-friendly for recording and playing back snoring sounds. Preliminary comparison of more than 1500 individual snores demonstrates the potential clinical utility of such apps; however, further validation testing is recommended.
C1 [Camacho, M.] Tripler Army Med Ctr, Div Otolaryngol Sleep Surg & Sleep Med, Honolulu, HI 96859 USA.
[Camacho, M.; Robertson, M.; Ruoff, C. M.] Stanford Hosp & Clin, Sleep Med Div, Dept Psychiat, Redwood City, CA USA.
[Abdullatif, J.] Hosp Bernardino Rivadavia, Dept Otorhinolaryngol, Buenos Aires, DF, Argentina.
[Certal, V.] Univ Porto, Ctr Res Hlth Technol & Informat Syst CINTESIS, Hosp CUF Porto, Dept Otorhinolaryngol,Sleep Med Ctr, P-4100 Oporto, Portugal.
[Kram, Y. A.] Univ Calif San Francisco, Dept Otolaryngol Head & Neck Surg, San Francisco, CA USA.
[Brietzke, S. E.] Walter Reed Natl Mil Med Ctr, Dept Otolaryngol Head & Neck Surg, Bethesda, MD USA.
[Capasso, R.] Stanford Hosp & Clin, Sleep Surg Div, Dept Otolaryngol Head & Neck Surg, Stanford, CA USA.
RP Camacho, M (reprint author), Tripler Army Med Ctr, Div Otolaryngol Sleep Surg & Sleep Med, 1 Jarrett White Rd, Honolulu, HI 96859 USA.
EM drcamachoent@yahoo.com
RI FMUP, CINTESIS/C-6631-2014;
OI FMUP, CINTESIS/0000-0001-7248-2086; Camacho, Macario/0000-0001-9200-9085
NR 11
TC 4
Z9 4
U1 4
U2 13
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0022-2151
EI 1748-5460
J9 J LARYNGOL OTOL
JI J. Laryngol. Otol.
PD OCT
PY 2015
VL 129
IS 10
BP 974
EP 979
DI 10.1017/S0022215115001978
PG 6
WC Otorhinolaryngology
SC Otorhinolaryngology
GA CT8BD
UT WOS:000363039000010
PM 26333720
ER
PT J
AU Giminaro, AV
Stratz, SA
Gill, JA
Auxier, JP
Oldham, CJ
Cook, MT
Auxier, JD
Molgaard, JJ
Hall, HL
AF Giminaro, Andrew V.
Stratz, S. Adam
Gill, Jonathan A.
Auxier, Jerrad P.
Oldham, C. J.
Cook, Matthew T.
Auxier, John D., II
Molgaard, Joshua J.
Hall, Howard L.
TI Compositional planning for development of synthetic urban nuclear melt
glass
SO JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
LA English
DT Article
DE Debris; Nuclear weapons; Surrogate; Nuclear forensics; Urban; Melt glass
ID DEBRIS; PARTICLES
AB A method is developed for predicting and formulating realistic synthetic post-detonation debris relevant to a nuclear surface detonation in arbitrary urban settings. Using these methods guides the development of synthetic debris that serves as a tool for developing and validating novel rapid forensic analysis methods. In order to accurately fabricate realistic homogenous surrogate material, the method incorporates regional soil compositions, land use data, and vehicle contributions to the urban environment.
C1 [Giminaro, Andrew V.; Stratz, S. Adam; Gill, Jonathan A.; Auxier, Jerrad P.; Oldham, C. J.; Cook, Matthew T.; Auxier, John D., II; Hall, Howard L.] Univ Tennessee, Dept Nucl Engn, Knoxville, TN 37996 USA.
[Auxier, John D., II; Hall, Howard L.] Univ Tennessee, Radiochem Ctr Excellence RCOE, Knoxville, TN 37996 USA.
[Hall, Howard L.] Univ Tennessee, Inst Nucl Secur, Knoxville, TN 37996 USA.
[Molgaard, Joshua J.] US Mil Acad, West Point, NY 10996 USA.
RP Giminaro, AV (reprint author), Univ Tennessee, Dept Nucl Engn, Knoxville, TN 37996 USA.
EM agiminar@vols.utk.edu
OI Cook, Matthew/0000-0002-3460-5011; Hall, Howard/0000-0002-4080-5159;
Auxier II, John /0000-0001-6234-6451
FU Stewardship Science Academic Alliances (SSAA) Program of National
Nuclear Security Administration (NNSA) [DE-NA0001983]
FX This work was performed under Grant Number DE-NA0001983 from the
Stewardship Science Academic Alliances (SSAA) Program of the National
Nuclear Security Administration (NNSA). The views and opinions expressed
here are those of the authors and do not necessarily reflect those of
the NNSA or the SSAA.
NR 15
TC 2
Z9 2
U1 2
U2 8
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0236-5731
EI 1588-2780
J9 J RADIOANAL NUCL CH
JI J. Radioanal. Nucl. Chem.
PD OCT
PY 2015
VL 306
IS 1
BP 175
EP 181
DI 10.1007/s10967-015-4061-1
PG 7
WC Chemistry, Analytical; Chemistry, Inorganic & Nuclear; Nuclear Science &
Technology
SC Chemistry; Nuclear Science & Technology
GA CT6XR
UT WOS:000362957300020
ER
PT J
AU Taylor, DE
AF Taylor, DeCarlos E.
TI Shock Compression of Boron Carbide: A Quantum Mechanical Analysis
SO JOURNAL OF THE AMERICAN CERAMIC SOCIETY
LA English
DT Article
ID B4C; CERAMICS; BEHAVIOR
AB The shock Hugoniot of boron carbide, from 0 to 80GPa, has been obtained using first principles quantum mechanics (density functional theory) and molecular dynamics simulation. The Hugoniot for six different structures which vary by structure or stoichiometry were computed and compared to experimental data. The effect of stoichiometry, and structural variation within a given stoichiometry, are shown to have marked effects on the shock properties with some compositions displaying bilinear behavior in the computed shock velocity-particle velocity profiles while others show a continuous Hugoniot curve with no evidence of a phase transition over the pressure range considered in this work. Two structures, B-12(CBC) and B11Cp(CCB), have predicted phase transition pressures lying within the 40-50GPa range suggested experimentally. It is shown that the phase transition is driven by deformation of the 3-atom chain within the boron carbide crystal structure which induces a discontinuous volume change at the critical shock pressure. The effect of defects, in the form of chain vacancies, on the shock response is presented and the ability of shear to significantly lower the phase transition pressure, in accord with experimental observation, is demonstrated.
C1 US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RP Taylor, DE (reprint author), US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
EM decarlos.e.taylor.civ@mail.mil
NR 36
TC 8
Z9 8
U1 3
U2 19
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0002-7820
EI 1551-2916
J9 J AM CERAM SOC
JI J. Am. Ceram. Soc.
PD OCT
PY 2015
VL 98
IS 10
BP 3308
EP 3318
DI 10.1111/jace.13711
PG 11
WC Materials Science, Ceramics
SC Materials Science
GA CT1YK
UT WOS:000362599000047
ER
PT J
AU Cain, DI
Sobel, EA
AF Cain, David I.
Sobel, Elizabeth A.
TI Sticks with Stones: An Experimental Test of the Effects of the Atlatl
Weight on Atlatl Mechanics
SO ETHNOARCHAEOLOGY
LA English
DT Article
DE Atlatl; dart; atlatl weight; bannerstone; Archaic; experimental
archaeology; projectile range; projectile precision
ID SPEAR-THROWER; PERFORMANCE
AB Archaeologists debate the impact of the North American atlatl weight on atlatl performance. Some argue that the atlatl weight offers an advantageous effect. Others believe it has no meaningful effect, and still others believe it has a disadvantageous effect. Experimentation is well suited to resolving this debate, but previous experiments have not produced replicable results due to the use of human atlatlists, which introduce uncontrolled biomechanical variation. We redress this problem through the construction and use of an atlatl launch machine, which provides unprecedented experimental control over mechanical variables, and hence unprecedented experimental objectivity and reproducibility. Using the machine, we test the Range and Precision Hypotheses of atlatl weight impact. Statistical analyses of data from 350 mechanized launches indicate that compared to the unweighted atlatl, the weighted atlatl typically has a lower range but greater precision, when all variables except the presence/absence of the atlatl weight are held constant. These results begin to help resolve the atlatl weight debate and have implications concerning the North American bannerstone, atlatl mechanics generally, and experimental atlatl research methods.
C1 [Cain, David I.] US Army Corps Engineers, Garrison Project, Riverdale, ND 58565 USA.
[Sobel, Elizabeth A.] SW Missouri State Univ, Dept Sociol & Anthropol, Springfield, MO 65897 USA.
RP Cain, DI (reprint author), US Army Corps Engineers, Garrison Project, 201 1st St, Riverdale, ND 58565 USA.
EM David.Cain2@usace.army.mil; esobel@missouristate.edu
NR 78
TC 0
Z9 0
U1 4
U2 4
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 1944-2904
EI 1944-2890
J9 ETHNOARCHAEOLOGY
JI Ethnoarchaeology
PD OCT
PY 2015
VL 7
IS 2
BP 114
EP 140
DI 10.1179/1944289015Z.00000000030
PG 27
WC Archaeology
SC Archaeology
GA CT5HO
UT WOS:000362839800003
ER
PT J
AU Johnson, JD
Cocker, K
Chang, E
AF Johnson, Jeremy D.
Cocker, Katherine
Chang, Elisabeth
TI Infantile Colic: Recognition and Treatment
SO AMERICAN FAMILY PHYSICIAN
LA English
DT Article
ID PLACEBO-CONTROLLED TRIAL; REUTERI DSM 17938; BREAST-FED INFANTS;
LACTOBACILLUS-REUTERI; DOUBLE-BLIND; FOENICULUM-VULGARE; FECAL
CALPROTECTIN; BABY BOTTLES; HERBAL TEA; PROBIOTICS
AB Infantile colic is a benign process in which an infant has paroxysms of inconsolable crying for more than three hours per day, more than three days per week, for longer than three weeks. It affects approximately 10% to 40% of infants worldwide and peaks at around six weeks of age, with symptoms resolving by three to six months of age. The incidence is equal between sexes, and there is no correlation with type Of feeding (breast vs. bottle), gestational age, or socioeconomic status. The cause of infantile colic is not known; proposed causes include alterations in fecal microflora, intolerance to cow's milk protein or lactose, gastrointestinal immaturity or inflammation, increased serotonin secretion, poor feeding technique, and maternal smoking or nicotine replacement therapy. Colic is a diagnosis of exclusion after a detailed history and physical examination have ruled out concerning causes. Parental support and reassurance are key components of the management of colic. Simethicone and proton pump inhibitors are ineffective for the treatment of colic, and dicyclomine is contraindicated. Treatment options for breastfed infants include the probiotic Lactobacillus reuteri (strain DSM 17938) and reducing maternal dietary allergen intake. Switching to a hydrolyzed formula is an option for formula-fed infants. Evidence does not support chiropractic or osteopathic manipulation, infant massage, swaddling, acupuncture, or herbal supplements. (Copyright (C) 2015 American Academy of Family Physicians.)
C1 [Johnson, Jeremy D.] Tripler Army Med Ctr, Dept Family Med, Honolulu, HI 96859 USA.
[Cocker, Katherine; Chang, Elisabeth] Tripler Army Med Ctr, Family Med Residency Program, Honolulu, HI 96859 USA.
RP Johnson, JD (reprint author), Tripler Army Med Ctr, Dept Family Med, Honolulu, HI 96859 USA.
EM jeremy.d.johnson68.mil@mail.mil
NR 42
TC 1
Z9 1
U1 5
U2 31
PU AMER ACAD FAMILY PHYSICIANS
PI KANSAS CITY
PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA
SN 0002-838X
EI 1532-0650
J9 AM FAM PHYSICIAN
JI Am. Fam. Physician
PD OCT 1
PY 2015
VL 92
IS 7
BP 577
EP 582
PG 6
WC Primary Health Care; Medicine, General & Internal
SC General & Internal Medicine
GA CS9BC
UT WOS:000362383100007
PM 26447441
ER
PT J
AU Bottoni, CR
Smith, EL
Shaha, J
Shaha, SS
Raybin, SG
Tokish, JM
Rowles, DJ
AF Bottoni, Craig R.
Smith, Eric L.
Shaha, James
Shaha, Steven S.
Raybin, Sarah G.
Tokish, John M.
Rowles, Douglas J.
TI Autograft Versus Allograft Anterior Cruciate Ligament Reconstruction: A
Prospective, Randomized Clinical Study With a Minimum 10-Year Follow-up
SO AMERICAN JOURNAL OF SPORTS MEDICINE
LA English
DT Article
DE anterior cruciate ligament; ACL; allograft; autograft; hamstring;
femoral cross-pin; long-term survival
ID ARTHROSCOPICALLY ASSISTED RECONSTRUCTION; HAMSTRING TENDON AUTOGRAFT;
INTERFERENCE SCREW FIXATION; PATELLAR-TENDON; GRACILIS TENDONS; BONE
ALLOGRAFTS; KNEE; SEMITENDINOSUS; METAANALYSIS; INJURIES
AB Background: The use of allografts for anterior cruciate ligament (ACL) reconstruction in young athletes is controversial. No long-term results have been published comparing tibialis posterior allografts to hamstring autografts.
Purpose: To evaluate the long-term results of primary ACL reconstruction using either an allograft or autograft.
Study Design: Randomized controlled trial; Level of evidence, 1.
Methods: From June 2002 to August 2003, patients with a symptomatic ACL-deficient knee were randomized to receive either a hamstring autograft or tibialis posterior allograft. All allografts were from a single tissue bank, aseptically processed, and fresh-frozen without terminal irradiation. Graft fixation was identical in all knees. All patients followed the same postoperative rehabilitation protocol, which was blinded to the therapists. Preoperative and postoperative assessments were performed via examination and/or telephone and Internet-based questionnaire to ascertain the functional and subjective status using established knee metrics. The primary outcome measures were graft integrity, subjective knee stability, and functional status.
Results: There were 99 patients (100 knees); 86 were men, and 95% were active-duty military. Both groups were similar in demographics and preoperative activity level. The mean and median ages of both groups were identical at 29 and 26 years, respectively. Concomitant meniscal and chondral pathologic abnormalities, microfracture, and meniscal repair performed at the time of reconstruction were similar in both groups. At a minimum of 10 years (range, 120-132 months) from surgery, 96 patients (97 knees) were contacted (2 patients were deceased, and 1 was unable to be located). There were 4 (8.3%) autograft and 13 (26.5%) allograft failures that required revision reconstruction. In the remaining patients whose graft was intact, there was no difference in the mean Single Assessment Numeric Evaluation, Tegner, or International Knee Documentation Committee scores.
Conclusion: At a minimum of 10 years after ACL reconstruction in a young athletic population, over 80% of all grafts were intact and had maintained stability. However, those patients who had an allograft failed at a rate over 3 times higher than those with an autograft.
C1 [Bottoni, Craig R.; Smith, Eric L.; Shaha, James; Shaha, Steven S.; Raybin, Sarah G.; Tokish, John M.; Rowles, Douglas J.] Tripler Army Med Ctr, Sports Med Sect, Orthopaed Surg Serv, Honolulu, HI 96859 USA.
RP Bottoni, CR (reprint author), Tripler Army Med Ctr, Sports Med Sect, Orthopaed Surg Serv, Honolulu, HI 96859 USA.
EM crbottoni@yahoo.com
FU Arthrex Inc; Musculoskeletal Transplant Foundation
FX One or more of the authors has declared the following potential conflict
of interest or source of funding: Research and institutional support was
received from Arthrex Inc and the Musculoskeletal Transplant Foundation.
C. R. B. and J. M. T. are consultants for Arthrex Inc.
NR 70
TC 12
Z9 13
U1 4
U2 19
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0363-5465
EI 1552-3365
J9 AM J SPORT MED
JI Am. J. Sports Med.
PD OCT
PY 2015
VL 43
IS 10
BP 2501
EP 2509
DI 10.1177/0363546515596406
PG 9
WC Orthopedics; Sport Sciences
SC Orthopedics; Sport Sciences
GA CS9WX
UT WOS:000362445100023
PM 26311445
ER
PT J
AU Hsu, MC
Wang, CL
Herrema, AJ
Schillinger, D
Ghoshal, A
Bazilevs, Y
AF Hsu, Ming-Chen
Wang, Chenglong
Herrema, Austin J.
Schillinger, Dominik
Ghoshal, Anindya
Bazilevs, Yuri
TI An interactive geometry modeling and parametric design platform for
isogeometric analysis
SO COMPUTERS & MATHEMATICS WITH APPLICATIONS
LA English
DT Article
DE Isogeometric analysis; NURBS and T-splines; Parametric design; Rhino and
Grasshopper; Visual programming; Graphical generative algorithms
ID FLUID-STRUCTURE INTERACTION; FINITE CELL METHOD; T-SPLINE CONSTRUCTION;
PHASE-FIELD MODEL; BIOPROSTHETIC HEART-VALVES; TRIMMED NURBS GEOMETRIES;
WIND TURBINE ROTORS; COLLOCATION METHODS; BOUNDARY-CONDITIONS; SHAPE
OPTIMIZATION
AB In this paper an interactive parametric design-through-analysis platform is proposed to help design engineers and analysts make more effective use of Isogeometric Analysis (IGA) to improve their product design and performance. We develop several Rhinoceros (Rhino) plug-ins to take input design parameters through a user-friendly interface, generate appropriate surface and/or volumetric models, perform mechanical analysis, and visualize the solution fields, all within the same Computer-Aided Design (CAD) program. As part of this effort we propose and implement graphical generative algorithms for IGA model creation and visualization based on Grasshopper, a visual programming interface to Rhino. The developed platform is demonstrated on two structural mechanics examples an actual wind turbine blade and a model of an integrally bladed rotor (IBR). In the latter example we demonstrate how the Rhino functionality may be utilized to create conforming volumetric models for IGA. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Hsu, Ming-Chen; Wang, Chenglong; Herrema, Austin J.] Iowa State Univ, Dept Mech Engn, Ames, IA 50011 USA.
[Schillinger, Dominik] Univ Minnesota, Dept Civil Engn, Minneapolis, MN 55455 USA.
[Ghoshal, Anindya] US Army, Res Lab, Vehicle Technol Directorate, Aberdeen Proving Ground, MD 21005 USA.
[Bazilevs, Yuri] Univ Calif San Diego, Dept Struct Engn, La Jolla, CA 92093 USA.
RP Hsu, MC (reprint author), Iowa State Univ, Dept Mech Engn, 2025 Black Engn, Ames, IA 50011 USA.
EM jmchsu@iastate.edu
RI Hsu, Ming-Chen/J-1881-2012;
OI Hsu, Ming-Chen/0000-0001-8062-8612; Herrema, Austin/0000-0002-3643-7867
FU ARO [W911NF-14-1-0296]; National Science Foundation [CNS-1156841]; US
National Science Foundation [DGE-1069283]
FX This work is partially supported by the ARO grant No. W911NF-14-1-0296,
Program Manager Dr. Joseph Myers. The work on IBR modeling was supported
by NAVAIR, Program Manager Dr. Nam Phan. This material is also partially
based upon work supported by the National Science Foundation under Grant
No. CNS-1156841. We thank Matthew Getch, Mariama Wilson, and Alexis
Moreno for their initial work on this research. A.J. Herrema is
supported by the US National Science Foundation Grant No. DGE-1069283
which funds the activities of the Integrative Graduate Education and
Research Traineeship (IGERT) in Wind Energy Science, Engineering and
Policy (WESEP) at Iowa State University.
NR 138
TC 6
Z9 6
U1 6
U2 38
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0898-1221
EI 1873-7668
J9 COMPUT MATH APPL
JI Comput. Math. Appl.
PD OCT
PY 2015
VL 70
IS 7
BP 1481
EP 1500
DI 10.1016/j.camwa.2015.04.002
PG 20
WC Mathematics, Applied
SC Mathematics
GA CT2FA
UT WOS:000362616200008
ER
PT J
AU Brodie, KL
Raubenheimer, B
Elgar, S
Slocum, RK
McNinch, JE
AF Brodie, K. L.
Raubenheimer, B.
Elgar, Steve
Slocum, R. K.
McNinch, J. E.
TI Lidar and Pressure Measurements of Inner-Surfzone Waves and Setup
SO JOURNAL OF ATMOSPHERIC AND OCEANIC TECHNOLOGY
LA English
DT Article
ID SUSPENDED SEDIMENT TRANSPORT; FIELD OBSERVATIONS; NATURAL BEACH; EDGE
WAVES; REFLECTED WAVES; BREAKING WAVES; 3-POINT METHOD; SLOPING BEACH;
GRAVITY-WAVES; SWASH ZONE
AB Observations of waves and setup on a steep, sandy beach are used to identify and assess potential applications of spatially dense lidar measurements for studying inner-surf and swash-zone hydrodynamics. There is good agreement between lidar- and pressure-based estimates of water levels (r(2) = 0.98, rmse = 0.05 m), setup (r(2) = 0.92, rmse = 0.03 m), infragravity wave heights (r(2) = 0.91, rmse = 0.03 m), swell-sea wave heights (r(2) = 0.87, rmse = 0.07 m), and energy density spectra. Lidar observations did not degrade with range (up to 65 m offshore of the lidar) when there was sufficient foam present on the water surface to generate returns, suggesting that for narrow-beam 1550-nm light, spatially varying spot size, grazing angle affects, and linear interpolation (to estimate the water surface over areas without returns) are not large sources of error. Consistent with prior studies, the lidar and pressure observations indicate that standing infragravity waves dominate inner-surf and swash energy at low frequencies and progressive swell-sea waves dominate at higher frequencies. The spatially dense lidar measurements enable estimates of reflection coefficients from pairs of locations at a range of spatial lags (thus spanning a wide range of frequencies or wavelengths). Reflection is high at low frequencies, increases with beach slope, and decreases with increasing offshore wave height, consistent with prior studies. Lidar data also indicate that wave asymmetry increases rapidly across the inner surf and swash. The comparisons with pressure measurements and with theory demonstrate that lidar measures inner-surf waves and setup accurately, and can be used for studies of inner-surf and swash-zone hydrodynamics.
C1 [Brodie, K. L.; Slocum, R. K.; McNinch, J. E.] US Army, Engineer Res & Dev Ctr, Coastal & Hydraul Lab, Duck, NC 27949 USA.
[Raubenheimer, B.; Elgar, Steve] Woods Hole Oceanog Inst, Woods Hole, MA 02543 USA.
RP Brodie, KL (reprint author), US Army, Engineer Res & Dev Ctr, Coastal & Hydraul Lab, 1261 Duck Rd, Duck, NC 27949 USA.
EM katherine.l.brodie@usace.army.mil
FU USACE Coastal Field Data Collection (CFDC); Coastal Ocean Data Systems
(CODS) programs; Office of Naval Research, the National Science
Foundation; Assistant Secretary of Defense (RE)
FX We thank Brian Scarborough, Jason Pipes, and Mark Preisser for erecting
the lidar scaffolding, for operating the jetting equipment used to
deploy and recover the instruments, and for clearing huge piles of sea
grass off the beach; Dan Freer for electronics support; Seth Zippel for
programming the pressure gauges and for retrieving the data; and Danik
Forsman, Melissa Moulton, Jenna Walker, and Regina Yopak for assisting
throughout the field study. Funding was provided by the USACE Coastal
Field Data Collection (CFDC) and Coastal Ocean Data Systems (CODS)
programs, the Office of Naval Research, the National Science Foundation,
and the Assistant Secretary of Defense (R&E).
NR 62
TC 3
Z9 3
U1 1
U2 5
PU AMER METEOROLOGICAL SOC
PI BOSTON
PA 45 BEACON ST, BOSTON, MA 02108-3693 USA
SN 0739-0572
EI 1520-0426
J9 J ATMOS OCEAN TECH
JI J. Atmos. Ocean. Technol.
PD OCT
PY 2015
VL 32
IS 10
BP 1945
EP 1959
DI 10.1175/JTECH-D-14-00222.1
PG 15
WC Engineering, Ocean; Meteorology & Atmospheric Sciences
SC Engineering; Meteorology & Atmospheric Sciences
GA CT0UX
UT WOS:000362514000016
ER
PT J
AU Hiller, T
Li, LL
Holthoff, EL
Bamieh, B
Turner, KL
AF Hiller, Tobias
Li, Lily Lijuan
Holthoff, Ellen L.
Bamieh, Bassam
Turner, Kimberly L.
TI System Identification, Design, and Implementation of Amplitude Feedback
Control on a Nonlinear Parametric MEM Resonator for Trace Nerve Agent
Sensing
SO JOURNAL OF MICROELECTROMECHANICAL SYSTEMS
LA English
DT Article
DE Nerve agent; DMMP; real-time mass sensing; nonlinear parametric
resonance; microbeam; system identification; robust H-infinity control
ID EXPLOSIVE DETECTION; SENSORS; MICROCANTILEVERS; DMMP
AB In this paper, we develop and experimentally verify a novel amplitude feedback control scheme on a silicon microbeam for real-time sensing of parts-per-trillion (ppt) nerve agent concentrations. Utilizing the nonlinear dynamics resulting from parametric excitation of the microbeam for sensing at atmospheric pressure has demonstrated superior performance compared with conventional linear forced sensing. The microbeam is coated with a molecularly imprinted polymer that selectively adsorbs dimethyl methylphosphonate (DMMP) a precursor to G-series nerve agents including sarin. When the molecules attach to the microbeam and increase its mass, the amplitude response described by the nonlinear dynamics shifts in frequency. In tracking this frequency shift, information about the mass load, and, therefore, the nerve agent concentration, can be extracted. Previous sensing schemes have successfully applied this concept while relying on experimentally designed controllers. This paper features a model-based approach starting with the nonlinear dynamics and system parameter identification. After linearization, a control designed with the Glover-McFarlane H-infinity loop-shaping procedure robustly stabilizes the system. The control scheme is implemented on a LabView field-programmable gate array. Water vapor and trace DMMP real-time experiments at atmospheric pressure demonstrate the control's functionality. A limit of detection of 13.3 ppt DMMP molecules in nitrogen is established. [2014-0330]
C1 [Hiller, Tobias; Li, Lily Lijuan; Bamieh, Bassam; Turner, Kimberly L.] Univ Calif Santa Barbara, Dept Mech Engn, Santa Barbara, CA 93106 USA.
[Holthoff, Ellen L.] Army Res Lab, Sensors & Devices Directorate, Adelphi, MD 20783 USA.
RP Hiller, T (reprint author), Univ Calif Santa Barbara, Dept Mech Engn, Santa Barbara, CA 93106 USA.
EM hillertobi@gmx.net; lily@engr.ucsb.edu; ellen.l.holthoff.civ@mail.mil;
bamieh@engineering.ucsb.edu; turner@engineering.ucsb.edu
FU Institute for Collaborative Biotechnologies through the U.S. Army
Research Office, Adelphi, MD, USA [W911NF-09-0001]
FX This work was supported by the Institute for Collaborative
Biotechnologies under Grant W911NF-09-0001 through the U.S. Army
Research Office, Adelphi, MD, USA. Subject Editor R. R. A. Syms.
NR 42
TC 2
Z9 2
U1 4
U2 14
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 1057-7157
EI 1941-0158
J9 J MICROELECTROMECH S
JI J. Microelectromech. Syst.
PD OCT
PY 2015
VL 24
IS 5
BP 1275
EP 1284
DI 10.1109/JMEMS.2015.2400398
PG 10
WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology;
Instruments & Instrumentation; Physics, Applied
SC Engineering; Science & Technology - Other Topics; Instruments &
Instrumentation; Physics
GA CS8RB
UT WOS:000362354900006
ER
PT J
AU Villarini, G
Scoccimarro, E
White, KD
Arnold, JR
Schilling, KE
Ghosh, J
AF Villarini, Gabriele
Scoccimarro, Enrico
White, Kathleen D.
Arnold, Jeffrey R.
Schilling, Keith E.
Ghosh, Joyee
TI Projected Changes in Discharge in an Agricultural Watershed in Iowa
SO JOURNAL OF THE AMERICAN WATER RESOURCES ASSOCIATION
LA English
DT Article
DE climate variability; change; rivers; streams; flooding; precipitation;
streamflow; time series analysis
ID CENTRAL UNITED-STATES; LAND-USE; CLIMATE-CHANGE; EXTREME EVENTS; RACCOON
RIVER; STREAMFLOW; MODELS; TRENDS; SCENARIOS; HYDROLOGY
AB Our improved capability to adapt to the future changes in discharge is linked to our capability to predict the magnitude or at least the direction of these changes. For the agricultural United States Midwest, too much or too little water has severe socioeconomic impacts. Here, we focus on the Raccoon River at Van Meter, Iowa, and use a statistical approach to examine projected changes in discharge. We build on statistical models using rainfall and harvested corn and soybean acreage to explain the observed discharge variability. We then use projections of these two predictors to examine the projected discharge response. Results are based on seven global climate models part of the Coupled Model Intercomparison Project Phase 5 and two representative concentration pathways (RCPs 4.5 and 8.5). There is not a strong signal of change in the discharge projections under the RCP 4.5. However, the results for the RCP 8.5 point to a stronger changing signal related to larger projected increases in rainfall, resulting in increased trends, in particular, in the upper part of the discharge distribution (i.e., 60th percentile and above). Examination of two hypothetical agricultural scenarios indicates that these increasing trends could be alleviated by decreasing the extent of the agricultural production. We also discuss how the methodology presented in this study represents a viable approach to move forward with the concept of return period for engineering design and management in a nonstationary world.
C1 [Villarini, Gabriele] Univ Iowa, IIHR Hydrosci & Engn, Iowa City, IA 52242 USA.
[Schilling, Keith E.] Univ Iowa, Iowa Geol Survey, Iowa City, IA 52242 USA.
[Ghosh, Joyee] Univ Iowa, Dept Stat & Actuarial Sci, Iowa City, IA 52242 USA.
[Scoccimarro, Enrico] Natl Inst Geophys & Volcanol, I-40127 Bologna, Italy.
[Scoccimarro, Enrico] Euromediterranean Ctr Climate Change, I-73100 Lecce, Italy.
[White, Kathleen D.; Arnold, Jeffrey R.] US Army Corps Engineers, Inst Water Resources, Alexandria, VA 22315 USA.
RP Villarini, G (reprint author), Univ Iowa, IIHR Hydrosci & Engn, 306 C Maxwell Stanley Hydraul Lab, Iowa City, IA 52242 USA.
EM gabriele-villarini@uiowa.edu
RI Villarini, Gabriele/F-8069-2016
OI Villarini, Gabriele/0000-0001-9566-2370
FU Center for Global and Regional Environmental Research (Seed Grant
Program); USACE Institute for Water Resources; University of Iowa; Iowa
Flood Center; IIHR-Hydroscience Engineering; Ministry for Environment,
Land and Sea through the project GEMINA
FX Gabriele Villarini acknowledges the financial support from the Center
for Global and Regional Environmental Research (Seed Grant Program), by
the USACE Institute for Water Resources, by the 2014 Old Gold Summer
Fellowship (the University of Iowa), and by the Iowa Flood Center, and
IIHR-Hydroscience & Engineering. Enrico Scoccimarro acknowledges the
support of the Ministry for Environment, Land and Sea through the
project GEMINA. We acknowledge the World Climate Research Programme's
Working Group on Coupled Modelling, which is responsible for CMIP, and
we thank the climate modeling groups (listed in Table 1) for producing
and making available their model output. For CMIP, the U.S. Department
of Energy's Program for Climate Model Diagnosis and Intercomparison
provides coordinating support and led development of software
infrastructure in partnership with the Global Organization for Earth
System Science Portals. The authors would also like to thank Dr.
Stasinopoulos, Dr. Rigby, and Dr. Akantziliotou for making the gamlss
package (Rigby and Stasinopoulos, 2005) freely available in R (R
Development Core Team, 2014). The comments and suggestions by three
anonymous reviewers are also acknowledged.
NR 41
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Z9 2
U1 0
U2 9
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1093-474X
EI 1752-1688
J9 J AM WATER RESOUR AS
JI J. Am. Water Resour. Assoc.
PD OCT
PY 2015
VL 51
IS 5
BP 1361
EP 1371
DI 10.1111/1752-1688.12318
PG 11
WC Engineering, Environmental; Geosciences, Multidisciplinary; Water
Resources
SC Engineering; Geology; Water Resources
GA CS8WG
UT WOS:000362369900014
ER
PT J
AU Walters, TJ
Garg, K
Corona, BT
AF Walters, Thomas J.
Garg, Koyal
Corona, Benjamin T.
TI ACTIVITY ATTENUATES SKELETAL MUSCLE FIBER DAMAGE AFTER ISCHEMIA AND
REPERFUSION
SO MUSCLE & NERVE
LA English
DT Article
DE exercise; junctophilin 1; muscle injury; rats; trauma
ID RAT STRIATED-MUSCLE; OPERATION ENDURING FREEDOM; CONTRACTION-INDUCED
INJURY; HIGH-INTENSITY EXERCISE; BONE-MARROW-CELLS; EARLY MOBILIZATION;
ECCENTRIC CONTRACTIONS; CRUSH INJURY; IN-VIVO; GASTROCNEMIUS-MUSCLE
AB Introduction: In this investigation we aimed to determine whether: (1) physical activity protects rat skeletal muscle from ischemia/reperfusion (I/R) injury; and (2) continued activity after I/R improves the rate of healing. Methods: Rats were divided into sedentary or active (voluntary wheel running) groups. Active rats ran for 4 weeks before I/R or 4 weeks before plus 4 weeks after I/R. Results: Activity before I/R resulted in 73.2% less muscle damage (Evans blue dye inclusion). Sedentary and active rats had a similar decline in neural- evoked (similar to 99%) and directly stimulated (similar to 70%) in vivo muscle torque, and a similar reduction in junctophilin 1. Active rats produced 19% and 15% greater neural- evoked torque compared with sedentary rats at 14 and 28 days postinjury, respectively, although the rate of recovery appeared similar. Conclusions: Activity protects against long-term muscle damage, but not short-term neural injury or excitation-contraction uncoupling. Continued activity neither accelerates nor hinders the rate of functional recovery.
C1 [Walters, Thomas J.; Garg, Koyal; Corona, Benjamin T.] US Army Inst Surg Res, Extrem Trauma & Regenerat Med Res Program, Ft Sam Houston, TX 78234 USA.
RP Corona, BT (reprint author), US Army Inst Surg Res, Extrem Trauma & Regenerat Med Res Program, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA.
EM benjamin.t.corona.vol@mail.mil
FU U.S. Army Medical Research and Medical Command Combat Casualty Care
Research Program
FX This work was funded by the U.S. Army Medical Research and Medical
Command Combat Casualty Care Research Program.
NR 62
TC 4
Z9 4
U1 0
U2 3
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0148-639X
EI 1097-4598
J9 MUSCLE NERVE
JI Muscle Nerve
PD OCT
PY 2015
VL 52
IS 4
BP 640
EP 648
DI 10.1002/mus.24581
PG 9
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA CT1FY
UT WOS:000362544400024
PM 25641705
ER
PT J
AU Veksler, VD
Myers, CW
Gluck, KA
AF Veksler, Vladislav D.
Myers, Christopher W.
Gluck, Kevin A.
TI Model Flexibility Analysis
SO PSYCHOLOGICAL REVIEW
LA English
DT Article
DE model evaluation; model selection; goodness of fit; model flexibility;
parametric complexity
ID COGNITIVE SCIENCE; RESPONSE-TIME; BAYES FACTORS; GOOD FIT;
REINFORCEMENT; PARAMETERS; SELECTION
AB A good fit of model predictions to empirical data are often used as an argument for model validity. However, if the model is flexible enough to fit a large proportion of potential empirical outcomes, finding a good fit becomes less meaningful. We propose a method for estimating the proportion of potential empirical outcomes that the model can fit: Model Flexibility Analysis (MFA). MFA aids model evaluation by providing a metric for gauging the persuasiveness of a given fit. We demonstrate that MFA can be more informative than merely discounting the fit by the number of free parameters in the model, and show how the number of free parameters does not necessarily correlate with the flexibility of the model. Additionally, we contrast MFA with other flexibility assessment techniques, including Parameter Space Partitioning, Model Mimicry, Minimum Description Length, and Prior Predictive Evaluation. Finally, we provide examples of how MFA can help to inform modeling results and discuss a variety of issues relating to the use of MFA in model validation.
C1 [Veksler, Vladislav D.] US Army, Res Lab, Human Res & Engn, DCS Corp, Aberdeen, MD 21001 USA.
[Myers, Christopher W.; Gluck, Kevin A.] US Air Force, Res Lab, Human Performance Wing 711, Wright Patterson AFB, OH 45433 USA.
RP Veksler, VD (reprint author), US Army, Res Lab, Bldg 417, Aberdeen, MD 21001 USA.
EM vdv718@gmail.com
FU Air Force Research Laboratory's Cognitive Models and Agents Branch;
AFOSR [13RH06COR]; Army Research Laboratory [W911NF-10-D-0002];
MindModeling.org; [W911NF-09-2-0053]
FX This research was performed partly while the first author held a
National Research Council Research Associateship Award with the Air
Force Research Laboratory's Cognitive Models and Agents Branch. A
majority of this work was supported by AFOSR Grant 13RH06COR. A part of
this work was performed by the first author as a DCS Corp contractor
under Army Research Laboratory contract W911NF-10-D-0002 and supporting
work funded under Cooperative Agreement Number W911NF-09-2-0053. We
thank Joseph W. Houpt and Matthew M. Walsh for their invaluable input.
We extend many thanks to the reviewers of this article, especially to
Peter Grunwald, who provided an extended review with a complete NML
tutorial. Additionally, we thank MindModeling.org for providing easy
access to large scale computing resources that supported this research.
NR 42
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U1 2
U2 7
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0033-295X
EI 1939-1471
J9 PSYCHOL REV
JI Psychol. Rev.
PD OCT
PY 2015
VL 122
IS 4
BP 755
EP 769
DI 10.1037/a0039657
PG 15
WC Psychology; Psychology, Multidisciplinary
SC Psychology
GA CT0UB
UT WOS:000362511500008
PM 26322547
ER
PT J
AU Guy, ED
Darko-Kagya, K
AF Guy, Erich D.
Darko-Kagya, Kenneth
TI Corrections for Problems Concerning the Scattering of Elastic Waves from
Planar Welded Interfaces
SO BULLETIN OF THE SEISMOLOGICAL SOCIETY OF AMERICA
LA English
DT Article
ID ZOEPPRITZ AMPLITUDE EQUATIONS; COMPRESSIONAL WAVES; TRANSMISSION;
REFLECTION
AB Equations describing the scattering of plane elastic waves from planar interfaces separating homogeneous and isotropic elastic media are complicated by mode conversions. This complexity has historically led to numerous publications containing erroneous solutions or misprints, many of which have been recognized. This article provides corrections for several additional related errors that have been noticed in the literature but not previously reported.
C1 [Guy, Erich D.; Darko-Kagya, Kenneth] US Army Corps Engineers, Geotech Engn Sect, Huntington, WV 25701 USA.
RP Guy, ED (reprint author), US Army Corps Engineers, Geotech Engn Sect, 502 Eighth St, Huntington, WV 25701 USA.
EM Erich.D.Guy@usace.army.mil; Kenneth.Darko@usace.army.mil
NR 22
TC 0
Z9 0
U1 0
U2 1
PU SEISMOLOGICAL SOC AMER
PI ALBANY
PA 400 EVELYN AVE, SUITE 201, ALBANY, CA 94706-1375 USA
SN 0037-1106
EI 1943-3573
J9 B SEISMOL SOC AM
JI Bull. Seismol. Soc. Amer.
PD OCT
PY 2015
VL 105
IS 5
BP 2830
EP 2834
DI 10.1785/0120150062
PG 5
WC Geochemistry & Geophysics
SC Geochemistry & Geophysics
GA CS5MP
UT WOS:000362122600037
ER
PT J
AU Tolmachoff, ED
Booth, AD
Lee, IC
Allmon, WR
Waits, CM
AF Tolmachoff, Erik D.
Booth, Alexander D.
Lee, Ivan C.
Allmon, William R.
Waits, Christopher M.
TI Modeling and experimental analysis of n-dodecane oxidation in
platinum-coated channels
SO COMBUSTION AND FLAME
LA English
DT Article
DE Microcombustion; Homogeneous-heterogeneous combustion; Portable power
conversion
ID HETERO-/HOMOGENEOUS COMBUSTION; FUELED CATALYTIC MICROREACTORS;
HYDROGEN/AIR MIXTURES; HOMOGENEOUS IGNITION; FLOW COMBUSTION;
METHANE/AIR MIXTURES; ELEVATED PRESSURES; 16 BAR; STABILITY; CHEMISTRY
AB In this work, a boundary layer fluid dynamics model is used to numerically investigate the heterogeneous/homogeneous combustion of n-dodecane in a platinum coated channel. An elementary lumped surface chemistry model is used to describe the oxidation of n-dodecane and its intermediates on Pt. A parallel plate microcombustor with Pt-coated walls was designed based on findings from the model. Experimental analysis of the n-dodecane/air fueled parallel plate microcombustor with Pt-coated walls shows that the combustor is capable of complete oxidation while operating at high temperatures (>1100 K) relevant to next generation thermal-to-electric power conversion. Chemiluminescence imaging in the combustor suggests that a weak flame exists, which is capable of driving oxidation to completion while avoiding extreme temperatures. This reactor shows promise as a heat source for high temperature compact thermal-to-electric power conversion. (C) 2015 The Combustion Institute. Published by Elsevier Inc. All rights reserved.
C1 [Tolmachoff, Erik D.; Booth, Alexander D.; Lee, Ivan C.; Allmon, William R.; Waits, Christopher M.] US Army Res Lab, Sensors & Elect Devices Directorate, Adelphi, MD 20783 USA.
RP Tolmachoff, ED (reprint author), US Army Res Lab, Sensors & Elect Devices Directorate, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM erik.d.tolmachoff.ctr@mail.mil
FU U.S. Army Research Laboratory Postdoctoral Fellowship Program
FX This research was supported in part by an appointment to the U.S. Army
Research Laboratory Postdoctoral Fellowship Program administered by the
Oak Ridge Associated Universities through a cooperative agreement with
the U.S. Army Research Laboratory. We would also like to thank the DOD
High Performance Computing group and especially Michael Lasinski for
their technical support.
NR 40
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Z9 4
U1 1
U2 10
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0010-2180
EI 1556-2921
J9 COMBUST FLAME
JI Combust. Flame
PD OCT
PY 2015
VL 162
IS 10
BP 3674
EP 3680
DI 10.1016/j.combustflame.2015.07.006
PG 7
WC Thermodynamics; Energy & Fuels; Engineering, Multidisciplinary;
Engineering, Chemical; Engineering, Mechanical
SC Thermodynamics; Energy & Fuels; Engineering
GA CS2TT
UT WOS:000361925600019
ER
PT J
AU Singamaneni, SR
Prater, JT
Narayan, J
AF Singamaneni, Srinivasa Rao
Prater, John T.
Narayan, Jagdish
TI Magnetic exchange coupling in bilayers of two epitaxial ferromagnetic
oxides
SO CURRENT OPINION IN SOLID STATE & MATERIALS SCIENCE
LA English
DT Review
DE La0.7Sr0.3MnO3/SrRuO3; Si (100); Antiferromagnetic coupling; Domain
matching epitaxy and pulsed laser deposition
ID INTERFACE; BIAS
AB Despite a decade of research effort on La0.7Sr0.3MnO3/SrRuO3 (LSMO/SRO) bilayers (BLs), a full knowledge on the magnetic properties and integration of these BLs on silicon substrate is not yet in sight. In this paper, we report on the magnetic exchange coupling observed from the above two ferromagnetic oxide thin film BLs, prepared through a novel approach, called 'domain matching epitaxy'. LSMO (100 nm)/SRO (45 nm) and LSMO (31 nm)/SRO (45 nm) bilayers have been epitaxially integrated with Si (100). Notably, in the former sample, positive exchange bias is observed - an indication of antiferromagnetic exchange coupling and is found to be absent in the latter. Furthermore, in the former sample, the cross-over from antiferromagnetic to ferromagnetic interface exchange coupling is noticed by varying the cooling field. We have verified that this coupling is of magnetic origin, not due to electrostatic interaction by inserting a thin (similar to 10 nm) SrTiO3 layer between LSMO and SRO. We believe that in addition to the formation of interface domain walls, the strong interplay among Zeeman, anisotropic and exchange energies could play a dominant role. Our results would have important implications for devices comprising of magnetic exchange coupled systems. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Singamaneni, Srinivasa Rao; Prater, John T.] US Army, Res Off, Div Mat Sci, Res Triangle Pk, NC 27709 USA.
[Singamaneni, Srinivasa Rao; Prater, John T.; Narayan, Jagdish] N Carolina State Univ, Dept Mat Sci & Engn, Raleigh, NC 27695 USA.
RP Singamaneni, SR (reprint author), N Carolina State Univ, Dept Mat Sci & Engn, Box 7907, Raleigh, NC 27695 USA.
EM ssingam@ncsu.edu
FU National Academy of Science (NAS), USA; Army Research Office
[W911NF-04-D-0003]; State of North Carolina; National Science Foundation
FX SSR acknowledges National Academy of Science (NAS), USA for awarding the
NRC postdoctoral research associate fellowship. The authors are pleased
to acknowledge the support of the Army Research Office under Grant
W911NF-04-D-0003. Also, the authors acknowledge the use of the
Analytical Instrumentation Facility (AIF) at North Carolina State
University, which is supported by the State of North Carolina and the
National Science Foundation.
NR 14
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U1 10
U2 40
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 1359-0286
EI 1879-0348
J9 CURR OPIN SOLID ST M
JI Curr. Opin. Solid State Mat. Sci.
PD OCT
PY 2015
VL 19
IS 5
BP 301
EP 304
DI 10.1016/j.cossms.2015.03.002
PG 4
WC Materials Science, Multidisciplinary; Physics, Applied; Physics,
Condensed Matter
SC Materials Science; Physics
GA CS4QG
UT WOS:000362060400004
ER
PT J
AU Nielsen, LE
Clifford, RJ
Kwak, Y
Preston, L
Argyros, C
Rabinowitz, R
Waterman, P
Lesho, E
AF Nielsen, L. E.
Clifford, R. J.
Kwak, Y.
Preston, L.
Argyros, C.
Rabinowitz, R.
Waterman, P.
Lesho, E.
TI An 11,000-isolate same plate/same day comparison of the 3 most widely
used platforms for analyzing multidrug-resistant clinical pathogens
SO DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
LA English
DT Article
DE Antibiotics; Carbapenemase; Vitek-2; Phoenix; MicroScan
ID INFECTIOUS-DISEASES-SOCIETY; BAD BUGS; VITEK 2; ENTEROBACTERIACEAE;
SURVEILLANCE; AMERICA; NETWORK; SYSTEMS; UPDATE; DRUGS
AB Stewardship of the dwindling number of effective antibiotics relies on accurate phenotyping. We sought to conduct the first large-scale, same plate and day comparison of the 3 most widely used bacterial analyzers. A total of 11,020 multidrug-resistant clinical isolates corresponding to more than 485,000 data points were used to compare the 3 major identification and antibiotic susceptibility testing (AST) platforms. Bacterial suspensions, prepared from a single plate, were simultaneously tested on all platforms in the same laboratory. Discrepancies were derived from MIC values using 2014 interpretive guidelines. Molecular methods and manual microbroth dilution were reference standards. Most discrepancies were due to drug-organism-AST platform combination instead of individual factors. MicroScan misidentified Acinetobacter baumannii (P < 0.001) and underestimated carbapenem susceptibility in Klebsiella pneumoniae. Vitek-2 and Phoenix had higher discrepancies for bla(KPC)-containing Enterobacteriaceae (P < 0.05) and reported false susceptibilities more often. While all platforms performed according to standards, each had strengths and weaknesses for organism identification, assaying specific drug-organism combinations and inferring carbapenemase production. Published by Elsevier Inc.
C1 [Nielsen, L. E.; Clifford, R. J.; Kwak, Y.; Preston, L.; Waterman, P.; Lesho, E.] Walter Reed Army Inst Res, Multidrug Resistant Organism Repository & Surveil, Silver Spring, MD 20910 USA.
[Nielsen, L. E.; Waterman, P.; Lesho, E.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
[Argyros, C.] Boston Coll, Dept Biol Sci, Chestnut Hill, MA 02467 USA.
[Rabinowitz, R.; Lesho, E.] Univ Maryland, Sch Med, Program Trauma Infect Dis, R Adams Cowley Shock Trauma Ctr, Baltimore, MD 21201 USA.
RP Nielsen, LE (reprint author), Walter Reed Army Inst Res, Multidrug Resistant Organism Repository & Surveil, Silver Spring, MD 20910 USA.
EM Lindsey.e.nielsen2.mil@mail.mil
FU US Army Medical Command; Armed Forces Health Surveillance Center's
Global Emerging Infections and Response System
FX This work was supported by the US Army Medical Command and the Armed
Forces Health Surveillance Center's Global Emerging Infections and
Response System.
NR 30
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Z9 3
U1 0
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0732-8893
EI 1879-0070
J9 DIAGN MICR INFEC DIS
JI Diagn. Microbiol. Infect. Dis.
PD OCT
PY 2015
VL 83
IS 2
BP 93
EP 98
DI 10.1016/j.diagmicrobio.2015.05.018
PG 6
WC Infectious Diseases; Microbiology
SC Infectious Diseases; Microbiology
GA CS8CA
UT WOS:000362312100002
PM 26117306
ER
PT J
AU Gulati, T
Datta, AK
Doona, CJ
Ruan, RR
Feeherry, FE
AF Gulati, Tushar
Datta, Ashim K.
Doona, Christopher J.
Ruan, R. Roger
Feeherry, Florence E.
TI Modeling moisture migration in a multi-domain food system: Application
to storage of a sandwich system
SO FOOD RESEARCH INTERNATIONAL
LA English
DT Article
DE Multi-domain foods; Porous media; Water activity; Moisture transport;
Capillary pressure
ID COMPOSITE FOOD; STARCHY FOODS; MASS-TRANSFER; POROUS-MEDIA; SHELF-LIFE;
PERMEABILITY; TRANSPORT; WATER; TEMPERATURE; DIFFUSIVITY
AB Moisture transport in a food system involving two different materials of unequal moisture content was modeled with water activity as the driving force using a porous media framework. This model was applied to a bread-barbecue chicken pocket sandwich stored in isothermal conditions. The model successfully predicted the equilibrium condition, where the two materials, bread and chicken, reached the same water activity, but not the same water content. The transient changes in the moisture content in the bread and chicken were predicted and shown to be significantly affected by air gap between the bread and chicken. The prediction process was also sensitive to the Darcy permeability values for the materials. The modeling framework presented for a sandwich system is very general and can easily be extended to other multicomponent food systems. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Gulati, Tushar; Datta, Ashim K.] Cornell Univ, Dept Biol & Environm Engn, Ithaca, NY USA.
[Doona, Christopher J.; Feeherry, Florence E.] US Army Natick Soldier Res, Ctr Dev & Engn, Warfighter Directorate, Natick, MA USA.
[Ruan, R. Roger] Univ Minnesota, Dept Bioprod & Biosyst Engn, St Paul, MN 55108 USA.
RP Datta, AK (reprint author), 208 Riley Robb Hall, Ithaca, NY 14853 USA.
EM akd1@cornell.edu
RI Gulati, Tushar/G-5627-2016; Datta, Ashim/K-2294-2012;
OI Gulati, Tushar/0000-0003-4836-7672; Datta, Ashim/0000-0002-1397-6892;
Ruan, Roger/0000-0001-8835-2649
NR 40
TC 2
Z9 2
U1 4
U2 14
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0963-9969
EI 1873-7145
J9 FOOD RES INT
JI Food Res. Int.
PD OCT
PY 2015
VL 76
BP 427
EP 438
DI 10.1016/j.foodres.2015.06.022
PN 3
PG 12
WC Food Science & Technology
SC Food Science & Technology
GA CS2TI
UT WOS:000361924500015
ER
PT J
AU Liao, LC
Drost, RJ
Li, ZN
Lang, T
Sadler, BM
Chen, G
AF Liao, Linchao
Drost, Robert J.
Li, Zening
Lang, Tian
Sadler, Brian M.
Chen, Gang
TI Long-distance non-line-of-sight ultraviolet communication channel
analysis: experimentation and modelling
SO IET OPTOELECTRONICS
LA English
DT Article; Proceedings Paper
CT 4th Colloquium on Optical-Wireless Communication (OWC)
CY JUL, 2014
CL Manchester, UNITED KINGDOM
DE optical communication; optical losses; Monte Carlo methods; atmospheric
turbulence; long-distance nonline-of-sight ultraviolet communication
channel analysis; path loss; pulse broadening effects; Monte Carlo
multiple-scattering channel model; theoretical modelling; turbulence
ID SCATTERING; NETWORKS; CONNECTIVITY; PROPAGATION; PERFORMANCE
AB In this study, the long-distance non-line-of-sight (NLOS) ultraviolet (UV) communication channel is characterised using experimental data and theoretical modelling. Experimental measurements of path loss and pulse broadening effects at distances of up to 4 km are reported and analysed, and comparisons between the field test data and a Monte Carlo multiple-scattering channel model provides strong evidence for the validity of the theoretical modelling approach. In addition, measurements probing the effects of turbulence are also considered, but in this case, the authors find limited experimental support for existing turbulence models, an important result suggesting the need for refined turbulence modelling. Finally, implications for NLOS UV communication performance at long ranges are examined. Overall, the experimental and numerical results serve to advance the study of NLOS UV channel modelling, an essential component of communication system design.
C1 [Liao, Linchao; Li, Zening; Lang, Tian; Chen, Gang] Univ Calif Riverside, Dept Elect Engn, Riverside, CA 92521 USA.
[Drost, Robert J.; Sadler, Brian M.] US Army Res Lab, Adelphi, MD 20783 USA.
RP Chen, G (reprint author), Univ Calif Riverside, Dept Elect Engn, Riverside, CA 92521 USA.
EM gachen@ee.ucr.edu
FU United States Army Research Office [W911NF-09-1-0293, W911NF-08-1-0163]
FX This work was supported in part by the United States Army Research
Office under grants W911NF-09-1-0293 and W911NF-08-1-0163.
NR 19
TC 1
Z9 1
U1 4
U2 10
PU INST ENGINEERING TECHNOLOGY-IET
PI HERTFORD
PA MICHAEL FARADAY HOUSE SIX HILLS WAY STEVENAGE, HERTFORD SG1 2AY, ENGLAND
SN 1751-8768
EI 1751-8776
J9 IET OPTOELECTRON
JI IET Optoelectron.
PD OCT
PY 2015
VL 9
IS 5
SI SI
BP 223
EP 231
DI 10.1049/iet-opt.2014.0121
PG 9
WC Engineering, Electrical & Electronic; Optics; Telecommunications
SC Engineering; Optics; Telecommunications
GA CS3CS
UT WOS:000361949600009
ER
PT J
AU Lesho, E
Carling, P
Hosford, E
Ong, A
Snesrud, E
Sparks, M
Onmus-Leone, F
Dzialowy, N
Fraser, S
Kwak, Y
Miller, S
Chukwuma, U
Julius, M
McGann, P
Clifford, R
AF Lesho, Emil
Carling, Philip
Hosford, Eve
Ong, Ana
Snesrud, Erik
Sparks, Michael
Onmus-Leone, Fatma
Dzialowy, Nicole
Fraser, Susan
Kwak, Yoon
Miller, Sonia
Chukwuma, Uzo
Julius, Michael
McGann, Patrick
Clifford, Robert
TI Relationships Among Cleaning, Environmental DNA, and
Healthcare-Associated Infections in a New Evidence-Based Design Hospital
SO INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
LA English
DT Article
ID ACINETOBACTER-BAUMANNII; STAPHYLOCOCCUS-AUREUS; SURFACES; OPPORTUNITIES;
TRANSMISSION; ROOM; ACQUISITION; PREVENTION; PATHOGENS; OUTBREAK
AB OBJECTIVE. Hospital environments influence healthcare-associated infection (HAI) patterns, but the role of evidenced-based design (EBD) and residual bacterial DNA (previously thought to be clinically inert) remain incompletely understood.
METHODS. In a newly built EBD hospital, we used culture-based and culture-free (molecular) assays, pulsed-field gel electrophoresis (PFGE), and whole-genome sequencing (WGS) to determine: (1) patterns of environmental contamination with target organisms (TOs) and multidrug-resistant (MDR) target organisms (MDR-TOs); (2) genetic relatedness between environmentally isolated MDR-TO and those from HAIs; and (3) correlation between surface contamination and HAIs.
RESULTS. A total of 1,273 high-touch surfaces were swabbed before and after terminal cleaning during 77 room visits. Of the 2,546 paired swabs, 47% had cultivable biomaterial and 42% had PCR-amplifiable DNA. The ratios of TOs detected to surfaces assayed were 85 per 1,273 for the culture-based method and 106 per 1,273 for the PCR-based method. Sinks, toilet rails, and bedside tables most frequently harbored biomaterial. Although cleaned surfaces were less likely to have cultivable TOs than precleaned surfaces, they were not less likely to harbor bacterial DNA. The rate of MDR-TOs to surfaces swabbed was 0.1% (3/2546). Although environmental MDR-TOs and MDR-TOs from HAIs were genetically related by PFGE, WGS revealed that they were unrelated. Environmental levels of cultivable Enterococcus spp. and E. coli DNA were positively correlated with infection incidences (P<.04 and P<.005, respectively).
CONCLUSION. MDR-TOs were rarely detected during surveillance and were not implicated in HAIs. The roles of environmental DNA and EBD, particularly with respect to water-associated fixtures or the potential suppression of cultivable environmental MDR-TOs, warrant multicenter investigations.
C1 [Lesho, Emil; Hosford, Eve; Ong, Ana; Snesrud, Erik; Sparks, Michael; Onmus-Leone, Fatma; Kwak, Yoon; Julius, Michael; McGann, Patrick; Clifford, Robert] Walter Reed Army Inst Res, Multidrug Resistant Organism Repository & Surveil, Silver Spring, MD USA.
[Carling, Philip] Boston Univ, Dept Med, Sch Med, Boston, MA 02215 USA.
[Dzialowy, Nicole; Chukwuma, Uzo] Navy & Marine Corps Public Hlth Ctr, Epidata Ctr Dept, Portsmouth, VA USA.
[Fraser, Susan; Miller, Sonia] Ft Belvoir Community Hosp, Ft Belvoir, VA USA.
RP Lesho, E (reprint author), 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM carolinelesho@yahoo.com
FU Military Infectious Disease Research Program; Congressional War
Supplement Fund; Global Emerging Infections Surveillance System; US Army
Medical Research and Materiel Command
FX Financial support: This work was supported by the Military Infectious
Disease Research Program; the Congressional War Supplement Fund; the
Global Emerging Infections Surveillance System; and the US Army Medical
Research and Materiel Command.
NR 29
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Z9 2
U1 0
U2 1
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 0899-823X
EI 1559-6834
J9 INFECT CONT HOSP EP
JI Infect. Control Hosp. Epidemiol.
PD OCT
PY 2015
VL 36
IS 10
BP 1130
EP 1138
DI 10.1017/ice.2015.151
PG 9
WC Public, Environmental & Occupational Health; Infectious Diseases
SC Public, Environmental & Occupational Health; Infectious Diseases
GA CS2RV
UT WOS:000361919700002
PM 26152338
ER
PT J
AU Doughty, RA
AF Doughty, Robert A.
TI "Papa" Joffre and the Great War
SO JOURNAL OF MILITARY HISTORY
LA English
DT Article
AB As commander of French forces in World War I from August 1914 until December 1916, General Joseph Joffre is one of the most controversial leaders of the war. As victor of the "miracle" of the Marne, he earned almost universal respect and admiration, but in subsequent years he came under scathing criticism for the enormous French casualties and for his failure to drive the Germans out of France. A strong supporter of the American Expeditionary Forces, he was praised by General John J. Pershing as "my loyal and consistent personal friend." This article attempts to determine whether Joffre's failures outweigh his successes in the enormously destructive and complex war.
C1 US Mil Acad, Dept Hist, West Point, NY 10996 USA.
RP Doughty, RA (reprint author), US Mil Acad, Dept Hist, West Point, NY 10996 USA.
NR 14
TC 0
Z9 0
U1 0
U2 1
PU SOC MILITARY HISTORY
PI LEXINGTON
PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA
24450-1600 USA
SN 0899-3718
EI 1543-7795
J9 J MILITARY HIST
JI J. Mil. Hist.
PD OCT
PY 2015
VL 79
IS 4
BP 959
EP 979
PG 21
WC History
SC History
GA CS5VA
UT WOS:000362145200003
ER
PT J
AU Connelly, DB
AF Connelly, Donald B.
TI The Impact of the First World War on US Policymakers: American Strategic
and Foreign Policy Formulation, 1938-1942
SO JOURNAL OF MILITARY HISTORY
LA English
DT Book Review
C1 [Connelly, Donald B.] US Army Command & Gen Staff Coll, Ft Leavenworth, KS 66027 USA.
RP Connelly, DB (reprint author), US Army Command & Gen Staff Coll, Ft Leavenworth, KS 66027 USA.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU SOC MILITARY HISTORY
PI LEXINGTON
PA C/O VIRGINIA MILITARY INST, GEORGE C MARSHALL LIBRARY, LEXINGTON, VA
24450-1600 USA
SN 0899-3718
EI 1543-7795
J9 J MILITARY HIST
JI J. Mil. Hist.
PD OCT
PY 2015
VL 79
IS 4
BP 1166
EP 1167
PG 2
WC History
SC History
GA CS5VA
UT WOS:000362145200042
ER
PT J
AU McLaughlin, JB
Ramos, V
AF McLaughlin, J. Bryan
Ramos, Van, Jr.
TI Complete denture fabrication with CAD/CAM record bases
SO JOURNAL OF PROSTHETIC DENTISTRY
LA English
DT Article
ID PROCESSING TECHNIQUE; RESIN BASES; TECHNOLOGY; HEAT
AB One of the primary goals of new materials and processes for complete denture fabrication has been to reduce polymerization shrinkage. The introduction of computer-aided design and computer-aided manufacturing (CAD/CAM) technology into complete denture fabrication has eliminated polymerization shrinkage in the definitive denture. The use of CAD/CAM record bases for complete denture fabrication can provide a better-fitting denture with fewer postprocessing occlusal errors.
C1 [McLaughlin, J. Bryan; Ramos, Van, Jr.] US Army Adv Educ Program Prosthodont, Ft Gordon, GA USA.
RP McLaughlin, JB (reprint author), 228 E Hosp Rd Tingay Dent Clin Bldg 320, Ft Gordon, GA 30905 USA.
EM james.b.mclaughlin1.mil@mail.mil
OI McLaughlin, James Bryan/0000-0003-4562-8080
FU United States Army Dental Corps
FX The authors thank the United States Army Dental Corps for the funding of
patient treatment and laboratory materials.
NR 22
TC 2
Z9 2
U1 1
U2 6
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0022-3913
EI 1097-6841
J9 J PROSTHET DENT
JI J. Prosthet. Dent.
PD OCT
PY 2015
VL 114
IS 4
BP 493
EP 497
PG 5
WC Dentistry, Oral Surgery & Medicine
SC Dentistry, Oral Surgery & Medicine
GA CS8BY
UT WOS:000362311900007
PM 26139040
ER
PT J
AU Wong, JY
Senatore, C
Jayakumar, P
Iagnemma, K
AF Wong, J. Y.
Senatore, C.
Jayakumar, P.
Iagnemma, K.
TI Predicting mobility performance of a small, lightweight track system
using the computer-aided method NTVPM
SO JOURNAL OF TERRAMECHANICS
LA English
DT Article
DE Applications of computer-aided methods; Cross-country performance;
Drawbar pull coefficient; Experimental study; Robotic tracked vehicles;
Sandy terrain
ID MODEL
AB This paper describes the results of a study of applying the physics-based, computer-aided method - the Nepean Tracked Vehicle Performance Model (NTVPM), originally developed for evaluating the mobility of large, heavy tracked vehicles, to predicting the performance of a small, lightweight track system on sandy soil. The objective is to examine the applicability of NTVPM to predicting the cross-country performance of small, lightweight tracked vehicles on deformable terrain. The performance of the track system predicted by NTVPM is compared with experimental data obtained in a laboratory soil bin by the Robotic Mobility Group, Massachusetts Institute of Technology. It is shown that the correlation between the tractive performance predicted by NTVPM and that measured is reasonably close, as indicated by the values of the coefficient of correlation, coefficient of determination, root mean squared deviation, and coefficient of variation. The results of this study provide evidence for supporting the view that physics-based methods, such as NTVPM, that are developed on the understanding of the physical nature and detailed analysis of vehicle-terrain interaction, are applicable to large, heavy, as well as small, lightweight vehicles, provided that appropriate terrain data are used as input. (C) 2015 ISTVS. Published by Elsevier Ltd. All rights reserved.
C1 [Wong, J. Y.] Vehicle Syst Dev Corp, Ottawa, ON, Canada.
[Senatore, C.; Iagnemma, K.] MIT, Cambridge, MA 02139 USA.
[Jayakumar, P.] US Army TARDEC, Warren, MI USA.
RP Wong, JY (reprint author), Vehicle Syst Dev Corp, Ottawa, ON, Canada.
EM vsdccanada@yahoo.ca; csenatore@exponent.com;
paramsothy.jayakumar.civ@mail.mil; kdi@mit.edu
FU U.S. Army Tank Automotive Research, Development and Engineering Center
(TARDEC); Army Research Office (ARO) [W911NF-13-1-0063]
FX The prediction of the track system performance using NTVPM and the
analysis of the correlations between the predicted and measured
performance presented in this paper were performed under the auspices of
Vehicle Systems Development Corporation (VSDC), Ottawa, Ontario, Canada.
The experimental data of track performance used in this paper were from
the Reference (Senatore et al., 2013). The study from which the
experimental data were produced was conducted by the Robotic Mobility
Group of the Massachusetts Institute of Technology (MIT) and supported
by the U.S. Army Tank Automotive Research, Development and Engineering
Center (TARDEC) and the Army Research Office (ARO) under Award No.
W911NF-13-1-0063.
NR 12
TC 3
Z9 4
U1 1
U2 3
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-4898
EI 1879-1204
J9 J TERRAMECHANICS
JI J. Terramech.
PD OCT
PY 2015
VL 61
BP 23
EP 32
DI 10.1016/j.jterra.2015.07.002
PG 10
WC Engineering, Environmental
SC Engineering
GA CS5RF
UT WOS:000362135000003
ER
PT J
AU Gray, JP
Vantsevich, VV
AF Gray, Jeremy P.
Vantsevich, Vladimir V.
TI Multi-vehicle convoy mobility in severe terrain conditions: Factor
impact analysis, estimation and control strategy
SO JOURNAL OF TERRAMECHANICS
LA English
DT Article
DE Vehicle convoy mobility; Multi-pass wheel track formation; Wheel power
distribution; Military; Unmanned ground vehicles; Control strategy
ID ROLLING RESISTANCE; SOIL COMPACTION; VEHICLE; DEFORMATION; TRACTORS
AB Military vehicle convoys are logistical supply chains that are heavily relied upon and are very often operated in severe terrain conditions. As it is shown in this article, the convoy mobility analytical estimation becomes a rather difficult task since the track, and thus tire-terrain interaction, is formed by multiple vehicles of a convoy driving over the same track. Furthermore, the distribution of power between the drive wheels of each convoy vehicle is a key factor in convoy mobility enhancement. A vehicle can be immobilized due to inappropriate combination of a power supply to a wheel and its poor tire-terrain properties. This leads to mobility loss of several or all the vehicles of the convoy. To the contrary, power wheel distributions concerted with wheel-terrain conditions improve mobility of a wheel, vehicle and the entire convoy. This article crystallizes the main factors that impact convoy mobility, discusses the factors at a descriptive level of vehicle dynamics control and then results in a convoy on-line mobility estimation and control strategy. Published by Elsevier Ltd. on behalf of ISTVS.
C1 [Gray, Jeremy P.] US Army TARDEC, Ground Vehicle Robot, Warren, MI 48397 USA.
[Vantsevich, Vladimir V.] Univ Alabama Birmingham, Dept Mech Engn, Birmingham, AL 35294 USA.
RP Gray, JP (reprint author), 6501 E 11 Mile Rd,RDTA RS MS264, Warren, MI 48397 USA.
EM jeremy.p.gray.civ@mail.mil; vantsevi@uab.edu
NR 52
TC 0
Z9 0
U1 1
U2 3
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-4898
EI 1879-1204
J9 J TERRAMECHANICS
JI J. Terramech.
PD OCT
PY 2015
VL 61
BP 43
EP 61
DI 10.1016/j.jterra.2015.04.002
PG 19
WC Engineering, Environmental
SC Engineering
GA CS5RF
UT WOS:000362135000005
ER
PT J
AU Shoop, SA
Coutermarsh, B
Cary, T
Howard, H
AF Shoop, S. A.
Coutermarsh, B.
Cary, T.
Howard, H.
TI Quantifying vegetation biomass impacts on vehicle mobility
SO JOURNAL OF TERRAMECHANICS
LA English
DT Article
DE Grass; Roots; Trafficability; Terrain; Traction; Motion resistance; Soil
strength; Rolling resistance
ID DIAMETER; LENGTH
AB Soil impacts on vehicle mobility are well known; however, most data are for bare soil or the type and amount of vegetation is not documented. This study summarizes results from experiments to quantify the effect of above ground and below ground vegetation biomass on vehicle performance. Soil-vegetation combinations of three soils and three grasses were used. The vegetation was tested at various growth stages and was also subjected to stressors such as trafficking, burning, and cutting. Vegetation measurements included above ground (leaves and shoots) and below ground (root) biomass weights, lengths, diameters and surface area parameters. The soils were characterized for size distribution, moisture, density and terrain strength for each test condition. Vehicle traction and motion resistance were measured for each soil grass combination using the CRREL Instrumented Vehicle. Results showed an increase in net traction biomass in sandy soils. For clay soils above ground biomass generally increased resistance while increased root diameter clearly decreased resistance. This study represents the first measurements quantifying the impacts of specific biomass parameters on vehicle mobility. The results will serve to guide new experimental methods, improve datasets, and develop physics-based models for years to come. Published by Elsevier Ltd. on behalf of ISTVS.
C1 [Shoop, S. A.; Coutermarsh, B.; Cary, T.; Howard, H.] US Army ERDC CRREL, Hanover, NH 03755 USA.
RP Shoop, SA (reprint author), US Army ERDC CRREL, 72 Lyme Rd, Hanover, NH 03755 USA.
EM sally.a.shoop@usace.army.mil
FU Corps of Engineers Engineering Research and Development Center; Optimal
Allocation of Land for Training and Non-Training Uses (OPAL) Soil
Strength Project; Terrestrial Geospatial Analysis for Ingress Locations
(GRAIL) Project
FX This work was funded through the Corps of Engineers Engineering Research
and Development Center, Optimal Allocation of Land for Training and
Non-Training Uses (OPAL) Soil Strength Project, and Terrestrial
Geospatial Analysis for Ingress Locations (GRAIL) Project. Construction
and initial trafficking and measurements of the test sections included
able assistance from Collin Judge, Charles Smith, Jesse Stanley, Bruce
Allen, Chris Berini, Trudy Fadden, Jen Helble, Hillary Bundick, and
Felicia Johnson. This work also benefited from many insightful
conversations with Mr. Alan Anderson, Technical Director of Military
Lands, Construction Engineering Research Laboratory (CERL).
NR 17
TC 0
Z9 0
U1 1
U2 3
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-4898
EI 1879-1204
J9 J TERRAMECHANICS
JI J. Terramech.
PD OCT
PY 2015
VL 61
BP 63
EP 76
DI 10.1016/j.jterra.2015.05.001
PG 14
WC Engineering, Environmental
SC Engineering
GA CS5RF
UT WOS:000362135000006
ER
PT J
AU Martini, WZ
Dubick, MA
AF Martini, Wenjun Z.
Dubick, Michael A.
TI Fibrinogen concentrate administration inhibits endogenous fibrinogen
synthesis in pigs after traumatic hemorrhage
SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
LA English
DT Article; Proceedings Paper
CT 73rd Annual Meeting of the
American-Association-for-the-Surgery-of-Trauma / Clinical Congress of
Acute Care Surgery
CY SEP 09-13, 2014
CL Philadelphia, PA
SP Amer Assoc Surg Trauma
DE Femur fracture; hemorrhagic shock; fibrinogen concentrate; endogenous
fibrinogen synthesis; pigs
ID LACTATED RINGERS RESUSCITATION; PLACEBO-CONTROLLED-TRIAL; TRANEXAMIC
ACID; TRANSFUSION REQUIREMENTS; PROPHYLACTIC FIBRINOGEN;
PLASMA-FIBRINOGEN; MAJOR TRAUMA; BLOOD-LOSS; COAGULATION; COAGULOPATHY
AB BACKGROUND Fibrinogen plays a central role in coagulation and falls to critical levels early after trauma. Administration of fibrinogen concentrate (FC) to improve hemostasis after severe bleeding seems beneficial, but it is unclear whether its use introduces excessive fibrinogen with a potential risk of thrombosis. This study investigated changes of endogenous fibrinogen metabolism from FC administration following traumatic hemorrhage in pigs.
METHODS Anesthetized, instrumented pigs were randomized into lactated Ringer's (LR) solution only and LR plus FC groups (n = 7 each). Femur fracture of each pig's left leg was followed by hemorrhage of 60% total blood volume and resuscitation with LR (3x bled volume, LR group) or LR plus FC at 250 mg/kg (LR-FC group). Afterward, a constant infusion of stable isotopes 1-C-13-phenylalanine (phe, 6 hours) and d(5)-phe (3 hours) was performed with hourly blood sampling and subsequent gas chromatography-mass spectrometry analysis to quantify fibrinogen synthesis and breakdown rates, respectively. Blood gas and coagulation indices (thromboelastography) were measured on intermittent blood samples, and hemodynamics was continuously monitored. Animals were euthanized after the 6-hour isotope period.
RESULTS Mean arterial pressure decreased by 50% after hemorrhage but improved after LR resuscitation in both groups. Hemorrhage and LR resuscitation reduced total protein, hematocrit, fibrinogen, and platelets to 50% of baseline values. Moreover, hemorrhage and resuscitation decreased fibrinogen concentration (207 6 vs. 132 +/- 7 mg/dL) and clot strength (72 +/- 2 vs. 63 +/- 2 mm) in both groups (p < 0.05). FC administration restored plasma fibrinogen concentrations and clot strength within 15 minutes, while no changes occurred in the LR group. Fibrinogen synthesis rates in the LR-FC group (1.3 +/- 0.2 mg/kg/h) decreased versus the LR group (3.1 +/- 0.5; p < 0.05), whereas fibrinogen breakdown rates were similar.
CONCLUSION Our data suggest an effective feedback mechanism that regulates host fibrinogen availability and thereby suggests that acute thrombosis from FC administration is an unlikely risk.
C1 [Martini, Wenjun Z.; Dubick, Michael A.] US Army, Inst Surg Res, San Antonio, TX USA.
RP Martini, WZ (reprint author), US Army, Inst Surg Res, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA.
EM wenjun.z.martini.civ@mail.mil
FU US Army Medical Research and Materiel Command
FX This study was supported by the US Army Medical Research and Materiel
Command.
NR 34
TC 3
Z9 3
U1 1
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 2163-0755
EI 2163-0763
J9 J TRAUMA ACUTE CARE
JI J. Trauma Acute Care Surg.
PD OCT
PY 2015
VL 79
IS 4
BP 540
EP 548
DI 10.1097/TA.0000000000000819
PG 9
WC Critical Care Medicine; Surgery
SC General & Internal Medicine; Surgery
GA CS5IZ
UT WOS:000362112900003
PM 26402526
ER
PT J
AU King, DR
Butler, F
Kragh, JF
AF King, David R.
Butler, Frank
Kragh, John F.
TI Re: Tourniquet use at the Boston Marathon bombing
SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
LA English
DT Letter
C1 [King, David R.] Harvard Univ, Sch Med, Knight Surg Res Lab, Div Trauma Acute Care Surg & Surg Crit Care, Boston, MA 02115 USA.
[King, David R.] Massachusetts Gen Hosp, Boston, MA 02114 USA.
[Butler, Frank] Dept Def Comm Tact Combat Casualty Care, Prehosp Care Branch, Dept Def Joint Trauma Syst, Def Hlth Board,Trauma & Injury Subcomm, Washington, DC USA.
[Kragh, John F.] USUHS Sch Med, US Army Inst Surg Res, Damage Control Resuscitat, San Antonio, TX USA.
RP King, DR (reprint author), Harvard Univ, Sch Med, Knight Surg Res Lab, Div Trauma Acute Care Surg & Surg Crit Care, Boston, MA 02115 USA.
OI King, David/0000-0003-1028-1478
NR 5
TC 2
Z9 2
U1 1
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 2163-0755
EI 2163-0763
J9 J TRAUMA ACUTE CARE
JI J. Trauma Acute Care Surg.
PD OCT
PY 2015
VL 79
IS 4
BP 702
EP 703
DI 10.1097/TA.0000000000000803
PG 2
WC Critical Care Medicine; Surgery
SC General & Internal Medicine; Surgery
GA CS5IZ
UT WOS:000362112900028
PM 26402551
ER
PT J
AU Burgess, E
AF Burgess, Edwin
TI The Lion of Sabray: The Afghani Warrior Who Defied the Taliban and Saved
the Life of Navy SEAL Marcus Luttrell
SO LIBRARY JOURNAL
LA English
DT Book Review
C1 [Burgess, Edwin] US Army Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA.
RP Burgess, E (reprint author), US Army Combined Arms Res Lib, Ft Leavenworth, KS 66027 USA.
NR 1
TC 0
Z9 0
U1 1
U2 1
PU REED BUSINESS INFORMATION
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA
SN 0363-0277
J9 LIBR J
JI Libr. J.
PD OCT 1
PY 2015
VL 140
IS 16
BP 94
EP 94
PG 1
WC Information Science & Library Science
SC Information Science & Library Science
GA CS6AC
UT WOS:000362158400165
ER
PT J
AU Janes, H
Herbeck, JT
Tovanabutra, S
Thomas, R
Frahm, N
Duerr, A
Hural, J
Corey, L
Self, SG
Buchbinder, SP
McElrath, MJ
O'Connell, RJ
Paris, RM
Rerks-Ngarm, S
Nitayaphan, S
Pitisuttihum, P
Kaewkungwal, J
Robb, ML
Michael, NL
Mullins, JI
Kim, JH
Gilbert, PB
Rolland, M
AF Janes, Holly
Herbeck, Joshua T.
Tovanabutra, Sodsai
Thomas, Rasmi
Frahm, Nicole
Duerr, Ann
Hural, John
Corey, Lawrence
Self, Steve G.
Buchbinder, Susan P.
McElrath, M. Juliana
O'Connell, Robert J.
Paris, Robert M.
Rerks-Ngarm, Supachai
Nitayaphan, Sorachai
Pitisuttihum, Punnee
Kaewkungwal, Jaranit
Robb, Merlin L.
Michael, Nelson L.
Mullins, James I.
Kim, Jerome H.
Gilbert, Peter B.
Rolland, Morgane
TI HIV-1 infections with multiple founders are associated with higher viral
loads than infections with single founders
SO NATURE MEDICINE
LA English
DT Article
ID DISEASE PROGRESSION; VACCINE EFFICACY; VIRUS; TRIAL; DIVERSITY;
VARIANTS; AIDSVAX; ALVAC; STEP
AB Given the variation in the HIV-1 viral load (VL) set point across subjects, as opposed to a fairly stable VL over time within an infected individual, it is important to identify the characteristics of the host and virus that affect VL set point. Although recently infected individuals with multiple phylogenetically linked HIV-1 founder variants represent a minority of HIV-1 infections, we found-in two different cohorts-that more diverse HIV-1 populations in early infection were associated with significantly higher VL 1 year after HIV-1 diagnosis.
C1 [Janes, Holly; Frahm, Nicole; Duerr, Ann; Hural, John; Corey, Lawrence; Self, Steve G.; Buchbinder, Susan P.; McElrath, M. Juliana; Gilbert, Peter B.] Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Div, Seattle, WA 98104 USA.
[Herbeck, Joshua T.; Frahm, Nicole; McElrath, M. Juliana] Univ Washington, Dept Global Hlth, Seattle, WA 98195 USA.
[Tovanabutra, Sodsai; Thomas, Rasmi; Paris, Robert M.; Robb, Merlin L.; Michael, Nelson L.; Kim, Jerome H.; Rolland, Morgane] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA.
[Tovanabutra, Sodsai; Thomas, Rasmi; Robb, Merlin L.; Rolland, Morgane] Henry M Jackson Fdn Adv Mil Med Inc, Bethesda, MD USA.
[McElrath, M. Juliana] Univ Washington, Dept Med, Seattle, WA USA.
[McElrath, M. Juliana] Univ Washington, Dept Lab Med, Seattle, WA 98195 USA.
[O'Connell, Robert J.; Nitayaphan, Sorachai] Armed Forces Res Inst Med Sci, Royal Thai Army Component, Bangkok 10400, Thailand.
[Rerks-Ngarm, Supachai] Minist Publ Hlth, Nonthaburi, Thailand.
[Pitisuttihum, Punnee; Kaewkungwal, Jaranit] Mahidol Univ, Fac Trop Med, Bangkok 10700, Thailand.
[Mullins, James I.] Univ Washington, Dept Microbiol, Seattle, WA 98195 USA.
RP Rolland, M (reprint author), Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA.
EM mrolland@hivresearch.org
FU National Institute of Allergy and Infectious Diseases: US Public Health
Service [AI41505]; US Army Medical Research and Material Command
[Y1-AI-2642-12]; US National Institutes of Health (NIH)
[2R37AI05465-10]; Henry M. Jackson Foundation for the Advancement of
Military Medicine, Inc. [W81XWH-07-2-0067]; US Department of Defense
[W81XWH-07-2-0067]
FX We would like to thank the participants in the Step study and the RV144
trial for their contributions to this research and Lisa Reilly for
editorial help. Sequencing and analysis were performed under grants from
the National Institute of Allergy and Infectious Diseases: US Public
Health Service grant AI41505; Interagency Agreement Y1-AI-2642-12 with
the US Army Medical Research and Material Command; US National
Institutes of Health (NIH) grant 2R37AI05465-10 to P.B.G. This work was
also supported by a cooperative agreement (W81XWH-07-2-0067) between the
Henry M. Jackson Foundation for the Advancement of Military Medicine,
Inc., and the US Department of Defense. The opinions expressed herein
are those of the authors and should not be construed as official or
representing the views of the US Department of Defense or the Department
of the Army. This does not alter our adherence to policies on sharing
data and materials.
NR 22
TC 6
Z9 6
U1 0
U2 3
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1078-8956
EI 1546-170X
J9 NAT MED
JI Nat. Med.
PD OCT
PY 2015
VL 21
IS 10
BP 1139
EP +
DI 10.1038/nm.3932
PG 4
WC Biochemistry & Molecular Biology; Cell Biology; Medicine, Research &
Experimental
SC Biochemistry & Molecular Biology; Cell Biology; Research & Experimental
Medicine
GA CS8RG
UT WOS:000362355400014
PM 26322580
ER
PT J
AU Holowchak, MA
Lavin, M
AF Holowchak, M. Andrew
Lavin, Michael
TI BEYOND THE DEATH DRIVE: The Future of "Repetition" and "Compulsion to
Repeat" in Psychopathology
SO PSYCHOANALYTIC PSYCHOLOGY
LA English
DT Article
DE Freud; repetition; repetition compulsion
ID PSYCHOTHERAPY; FREUD
AB Literature on Freud's use of "repetition" exists only insofar as it relates to shedding light on "repetition compulsion." Nevertheless, understanding Freud's use of "compulsion to repeat" is impossible without historical engagement, first, with its development over time and, second, with its relation to Freud's earlier uses of repetition both in and outside of the clinic. This article is a critical reading of Freud's employment of both repetition and repetition compulsion. We ask: How does compulsion to repeat differ from repetition? How do compulsions to repeat, given as evidence of the death drive, differ from compulsions to repeat that are consistent with the pleasure principle? Finally, is compulsion to repeat salvageable?
C1 [Holowchak, M. Andrew] Rider Univ, Dept Philosophy, Lawrenceville, NJ 08648 USA.
[Lavin, Michael] Brooke Army Med Ctr, Dept Behav Hlth, Intens Outpatient Program, San Antonio, TX USA.
RP Holowchak, MA (reprint author), Rider Univ, Dept Philosophy, New Acad Bldg, Lawrenceville, NJ 08648 USA.
EM MHolowchak@hotmail.com
NR 49
TC 0
Z9 0
U1 3
U2 10
PU EDUCATIONAL PUBLISHING FOUNDATION-AMERICAN PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST, NE, WASHINGTON, DC 20002-4242 USA
SN 0736-9735
EI 1939-1331
J9 PSYCHOANAL PSYCHOL
JI Psychoanal. Psychol.
PD OCT
PY 2015
VL 32
IS 4
BP 645
EP 668
DI 10.1037/a0037859
PG 24
WC Psychology, Clinical; Psychology, Psychoanalysis
SC Psychology
GA CS2FR
UT WOS:000361884100005
ER
PT J
AU Nee, R
Martinez-Osorio, J
Yuan, CM
Little, DJ
Watson, MA
Agodoa, L
Abbott, KC
AF Nee, Robert
Martinez-Osorio, Jorge
Yuan, Christina M.
Little, Dustin J.
Watson, Maura A.
Agodoa, Lawrence
Abbott, Kevin C.
TI Survival Disparity of African American Versus Non-African American
Patients With ESRD Due to SLE
SO AMERICAN JOURNAL OF KIDNEY DISEASES
LA English
DT Article
DE Racial disparity; survival disparity; systemic lupus erythematosus
(SLE); lupus nephritis; end-stage renal disease (ESRD); dialysis;
all-cause mortality; African American; US Renal Data System (USRDS);
competing risk; kidney transplantation
ID LUPUS NEPHRITIS; UNITED-STATES; SOCIOECONOMIC-STATUS;
RACIAL-DIFFERENCES; DIALYSIS PATIENTS; KIDNEY-DISEASE; RENAL-FAILURE;
RACE; TRANSPLANT; ETHNICITY
AB Background: A recent study showed an increased risk of death in African Americans compared with whites with end-stage renal disease (ESRD) due to lupus nephritis (LN). We assessed the impact of age stratification, socioeconomic factors, and kidney transplantation on the disparity in patient survival among African American versus non-African American patients with LN-caused ESRD, compared with other causes.
Study Design: Retrospective cohort study.
Setting & Participants: Using the US Renal Data System database, we identified 12,352 patients with LN-caused ESRD among 1,132,202 patients who initiated maintenance dialysis therapy from January 1, 1995, through December 31, 2006, and were followed up until December 31, 2010.
Predictors: Baseline demographics and comorbid conditions, Hispanic ethnicity, socioeconomic factors (employment status, Medicare/Medicaid insurance, and area-level median household income based on zip code as obtained from the 2000 US census), and kidney transplantation as a time-dependent variable.
Outcome: All-cause mortality.
Measurements: Multivariable Cox and competing-risk regressions.
Results: Mean duration of follow-up in the LN-caused ESRD and other-cause ESRD cohorts were 6.24 +/- 4.20 (SD) and 4.06 +/- 3.61 years, respectively. 6,106 patients with LN-caused ESRD (49.43%) and 853,762 patients with other-cause ESRD (76.24%) died during the study period (P < 0.001). Patients with LN-caused ESRD were significantly younger (mean age, 39.92 years) and more likely women (81.65%) and African American (48.13%) than those with other-cause ESRD. In the fully adjusted multivariable Cox regression model, African American (vs non-African American) patients with LN-caused ESRD had significantly increased risk of death at age 18 to 30 years (adjusted HR, 1.43; 95% CI, 1.24-1.65) and at age 31 to 40 years (adjusted HR, 1.17; 95% CI, 1.02-1.34). Among patients with other-cause ESRD, African Americans were at significantly increased risk at age 18 to 30 years (adjusted HR, 1.17; 95% CI, 1.11-1.22).
Limitations: We used zip code-based median household income as a surrogate for patient income. Residual socioeconomic confounders may exist.
Conclusions: African Americans are at significantly increased risk of death compared with non-African Americans with LN-caused ESRD at age 18 to 40 years, a racial disparity risk that is 10 years longer than that in the general ESRD population. Accounting for area-level median household income and transplantation significantly attenuated the disparity in mortality of African American versus non-African American patients with LN-caused ESRD. Published by Elsevier Inc.
C1 [Nee, Robert; Yuan, Christina M.; Little, Dustin J.; Watson, Maura A.; Abbott, Kevin C.] Walter Reed Natl Mil Med Ctr, Nephrol, Bethesda, MD 20889 USA.
[Martinez-Osorio, Jorge] Tripler Army Med Ctr, Nephrol, Honolulu, HI 96859 USA.
[Agodoa, Lawrence] NIDDK, NIH, Bethesda, MD USA.
RP Nee, R (reprint author), Walter Reed Natl Mil Med Ctr, Serv Nephrol, 8901 Wisconsin Ave, Bethesda, MD 20889 USA.
EM robert.nee.civ@mail.mil
OI Abbott, Kevin/0000-0003-2111-7112
NR 28
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Z9 5
U1 1
U2 3
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0272-6386
EI 1523-6838
J9 AM J KIDNEY DIS
JI Am. J. Kidney Dis.
PD OCT
PY 2015
VL 66
IS 4
BP 630
EP 637
DI 10.1053/j.ajkd.2015.04.011
PG 8
WC Urology & Nephrology
SC Urology & Nephrology
GA CS1JK
UT WOS:000361820100019
PM 26002293
ER
PT J
AU Capaldi, VF
Kim, JR
Grillakis, AA
Taylor, MR
York, CM
AF Capaldi, Vincent F., II
Kim, Jessica R.
Grillakis, Antigone A.
Taylor, Maura R.
York, Carla M.
TI Insomnia in the Military: Application and Effectiveness of Cognitive and
Pharmacologic Therapies
SO CURRENT PSYCHIATRY REPORTS
LA English
DT Review
DE Insomnia; Military; Cognitive behavioral therapy for insomnia; Sleep
ID RANDOMIZED CONTROLLED-TRIAL; POSTTRAUMATIC-STRESS-DISORDER; OBSTRUCTIVE
SLEEP-APNEA; BEHAVIORAL THERAPY; COMBAT VETERANS; PTSD; NIGHTMARES;
HEALTH; IRAQ; DISSEMINATION
AB Insomnia is one of the most common complaints of US armed service members. Diagnosis and treatment of insomnia in active duty and veteran populations are often complicated by comorbid disorders experienced by military personnel, such as post-traumatic stress disorder (PTSD) and traumatic brain injury (TBI). Cognitive behavioral therapy for insomnia (CBTi), pharmacologic interventions, and alternative therapies are discussed as relevant to their applications within military populations. Future directions in research are suggested.
C1 [Capaldi, Vincent F., II; Kim, Jessica R.; Grillakis, Antigone A.; Taylor, Maura R.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA.
[York, Carla M.] Walter Reed Natl Mil Med Ctr, Sleep Disorders Ctr, Bethesda, MD 20889 USA.
RP Capaldi, VF (reprint author), Walter Reed Army Inst Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM Vincent.f.capaldi.mil@mail.mil
NR 51
TC 1
Z9 1
U1 0
U2 15
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1523-3812
EI 1535-1645
J9 CURR PSYCHIAT REP
JI Curr. Psychiatry Rep.
PD OCT
PY 2015
VL 17
IS 10
AR 85
DI 10.1007/s11920-015-0622-9
PG 10
WC Psychiatry
SC Psychiatry
GA CR8MR
UT WOS:000361608100009
PM 26364060
ER
PT J
AU Brannick, EM
DeWilde, CA
Frey, E
Gluckman, TL
Keen, JL
Larsen, MR
Mont, SL
Rosenbaum, MD
Stafford, JR
Helke, KL
AF Brannick, Erin M.
DeWilde, Caitlin A.
Frey, Erin
Gluckman, Tracy L.
Keen, Jeremy L.
Larsen, Michelle R.
Mont, Stephanie L.
Rosenbaum, Matthew D.
Stafford, Julie R.
Helke, Kristi L.
TI Taking stock and making strides toward wellness in the veterinary
workplace
SO JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION
LA English
DT Editorial Material
ID COMPASSION FATIGUE; OCCUPATIONAL STRESS; COPING STRATEGIES; TRAUMATIC
STRESS; MENTAL-HEALTH; BURNOUT; SATISFACTION; SURGEONS; RISK; PROFESSION
C1 [Brannick, Erin M.] Univ Delaware, Dept Anim & Food Sci, Coll Agr & Nat Resources, Newark, DE 19716 USA.
[DeWilde, Caitlin A.] Brentwood Anim Hosp, Brentwood, MO 63144 USA.
[Gluckman, Tracy L.] Northwestern Univ, Ctr Comparat Med, Chicago, IL 60611 USA.
[Keen, Jeremy L.] North Madison Anim Hosp, Jackson, TN 38305 USA.
[Larsen, Michelle R.] Emergency Anim Clin, Avondale, AZ 85392 USA.
[Mont, Stephanie L.] US Army, Army Med Dept Ctr & Sch, Hlth Readiness Ctr Excellence, Dept Vet Sci,JBSA, Ft Sam Houston, TX 78234 USA.
[Rosenbaum, Matthew D.] Natl Jewish Hlth, Biol Resource Ctr, Denver, CO 80206 USA.
[Stafford, Julie R.] John Day River Vet Ctr, John Day, OR 97845 USA.
[Helke, Kristi L.] Med Univ S Carolina, Dept Comparat Med, Coll Med, Charleston, SC 29425 USA.
RP Brannick, EM (reprint author), Univ Delaware, Dept Anim & Food Sci, Coll Agr & Nat Resources, Newark, DE 19716 USA.
EM brannick@udel.edu
OI Helke, Kris/0000-0001-9746-0764
NR 37
TC 5
Z9 5
U1 5
U2 20
PU AMER VETERINARY MEDICAL ASSOC
PI SCHAUMBURG
PA 1931 N MEACHAM RD SUITE 100, SCHAUMBURG, IL 60173-4360 USA
SN 0003-1488
EI 1943-569X
J9 JAVMA-J AM VET MED A
JI JAVMA-J. Am. Vet. Med. Assoc.
PD OCT 1
PY 2015
VL 247
IS 7
BP 739
EP 742
PG 4
WC Veterinary Sciences
SC Veterinary Sciences
GA CR7IS
UT WOS:000361523400010
PM 26383746
ER
PT J
AU Moreu, F
Jo, H
Li, J
Kim, RE
Cho, S
Kimmle, A
Scola, S
Le, H
Spencer, BF
LaFave, JM
AF Moreu, F.
Jo, H.
Li, J.
Kim, R. E.
Cho, S.
Kimmle, A.
Scola, S.
Le, H.
Spencer, B. F., Jr.
LaFave, J. M.
TI Dynamic Assessment of Timber Railroad Bridges Using Displacements
SO JOURNAL OF BRIDGE ENGINEERING
LA English
DT Article
ID ROBOTIC TOTAL STATION; SPAN RAILWAY BRIDGE; TRAIN; DEFLECTIONS; SYSTEM;
FIELD
AB Infrastructure spending is such a large component of a railroad budget that it must be prioritized to meet the concurrent safety and line capacity requirements. Current bridge inspection and rating practices recommend observing bridge movements under a live load to help assess bridge conditions. However, measuring bridge movements under trains in the field is a challenging task. Even when they are measured, the relationships between bridge displacements and different loads/speeds are generally unknown. The research reported herein shows the effects of known train loadings, speeds, and traffic directions on the magnitude and frequency of displacements as measured on timber pile bents of a Class I railroad bridge. Researchers collected both vertical and transverse (lateral) displacements under revenue service traffic and work trains using LVDTs with a sampling frequency of 100 Hz. To investigate the effect of traffic on timber railroad bridges, displacements were measured under crossing events at different speeds and directions of a test train of known speed and weight provided by the railroad for the field experiment. The results indicate that bridge transverse displacements could help to capture critical changes in timber railroad bridge serviceability (i.e., ability to safely carry out railroad operations) as a function of railroad loading, speed, and direction. (C) 2014 American Society of Civil Engineers.
C1 [Moreu, F.; Kim, R. E.] Univ Illinois, Dept Civil & Environm Engn, Urbana, IL 61801 USA.
[Jo, H.] Univ Arizona, Civil Engn & Engn Mech Dept, Tucson, AZ 85721 USA.
[Li, J.] Univ Kansas, Dept Civil Environm & Architectural Engn, Lawrence, KS 66045 USA.
[Cho, S.] Ulsan Natl Inst Sci & Technol, Sch Urban & Environm Engn, Ulsan 689798, South Korea.
[Kimmle, A.] US Army, Construct Engn Res Lab, Champaign, IL 61826 USA.
[Scola, S.] Canadian Natl Railway, Bridges & Struct, Homewood, IL 60430 USA.
[Le, H.] Canadian Natl Railway, Bridge Assessment, Homewood, IL 60430 USA.
[Spencer, B. F., Jr.] Univ Illinois, Dept Civil & Environm Engn, Newmark Struct Engn Lab, Nathan M & Anne M Newmark Endowed Chair Civil Eng, Urbana, IL 61801 USA.
[LaFave, J. M.] Univ Illinois, Dept Civil & Environm Engn, Urbana, IL 61801 USA.
RP Moreu, F (reprint author), Univ Illinois, Dept Civil & Environm Engn, 2152 Newmark Civil Engn Lab,205 N Matthews Ave, Urbana, IL 61801 USA.
EM moreualo@illinois.edu
FU Association of American Railroads Technology Scanning Program; O. H.
Ammann Research Fellowship of the Structural Engineering Institute-ASCE;
Talentia Fellowship (Junta de Andalucia, Spain); Illinois Graduate
College Dissertation Travel Committee at the University of Illinois at
Urbana-Champaign
FX The financial support for this research is gratefully acknowledged from
the following sources: Association of American Railroads Technology
Scanning Program; O. H. Ammann Research Fellowship of the Structural
Engineering Institute-ASCE; Talentia Fellowship (Junta de Andalucia,
Spain); and Illinois Graduate College Dissertation Travel Committee at
the University of Illinois at Urbana-Champaign. The authors thank the
Canadian National Railway (CN) bridge testing team for their support in
the monitoring campaign of the U2.60 Bluford Bridge: Dave Roberts, Vamsi
Tolikonda, and Zhenyu Zhao. The assistance and suggestions from Mark
Paull from CN and Mike Dooley from ESCA Consultants are appreciated.
Finally, Dan Painter (ROW Consultants) provided protection during the
bridge monitoring.
NR 32
TC 2
Z9 2
U1 1
U2 10
PU ASCE-AMER SOC CIVIL ENGINEERS
PI RESTON
PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA
SN 1084-0702
EI 1943-5592
J9 J BRIDGE ENG
JI J. Bridge Eng.
PD OCT
PY 2015
VL 20
IS 10
AR 04014114
DI 10.1061/(ASCE)BE.1943-5592.0000726
PG 12
WC Engineering, Civil
SC Engineering
GA CR7UU
UT WOS:000361557800011
ER
PT J
AU Choi, YS
Cucura, J
Jain, R
Berry-Caban, C
AF Choi, Y. Sammy
Cucura, Jon
Jain, Ram
Berry-Caban, Cristobal
TI Telemedicine in US Army soldiers with type 1 diabetes
SO JOURNAL OF TELEMEDICINE AND TELECARE
LA English
DT Article
DE Type 1 diabetes; telemedicine; military; soldiers
ID MANAGEMENT; EXERCISE; INDIVIDUALS; RUNNERS
AB A retrospective study of a telemedicine clinic for active duty US Army soldiers with type 1 diabetes was conducted. Fifty-one consecutive patients (mean age 33.9 years) were enrolled into the clinic. All soldiers with known or newly diagnosed type 1 diabetes received three weekly office visits for intensive diabetes education. After this, all communication occurred via a messaging system consisting of texting, web-based download, and/or email to a diabetes management team. For urgent matters, 24/7 direct paging or telephone access was provided. Routine adjustments in insulin dosing were accomplished via email. Soldiers were followed for a mean of 17.1 months. Baseline, three-month, and end of study glycated hemoglobin (A1C) values were 9.8, 7.3, and 6.9, respectively. There were no significant differences in end of study A1C levels between patients with known vs. newly diagnosed type 1 diabetes, nor were there any differences between those patients who received insulin via pump therapy vs. multiple daily injections. Telemedicine was safe and effective in lowering A1C levels in US Army soldiers with type 1 diabetes.
C1 [Choi, Y. Sammy; Cucura, Jon] Dept Med, Ft Bragg, NC USA.
[Choi, Y. Sammy; Jain, Ram; Berry-Caban, Cristobal] Dept Clin Invest, Ft Bragg, NC 28310 USA.
[Jain, Ram] EmpiriStat Inc, Mt Airy, MD USA.
RP Choi, YS (reprint author), Dept Clin Invest, Ft Bragg, NC 28310 USA.
EM young.s.choi.civ@mail.mil
NR 25
TC 1
Z9 1
U1 0
U2 3
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1357-633X
EI 1758-1109
J9 J TELEMED TELECARE
JI J. Telemed. Telecare
PD OCT
PY 2015
VL 21
IS 7
BP 392
EP 395
DI 10.1177/1357633X15583425
PG 4
WC Health Care Sciences & Services
SC Health Care Sciences & Services
GA CR8NF
UT WOS:000361609900004
PM 26033845
ER
PT J
AU Li, X
Li, PC
Ji, L
Stender, C
McPheeters, C
Tatavarti, SR
Sablon, K
Yu, ET
AF Li, Xiaohan
Li, Ping-Chun
Ji, Li
Stender, Christopher
McPheeters, Claiborne
Tatavarti, Sudersena Rao
Sablon, Kimberly
Yu, Edward T.
TI Subwavelength nanostructures integrated with polymer-packaged iii-v
solar cells for omnidirectional, broad-spectrum improvement of
photovoltaic performance
SO PROGRESS IN PHOTOVOLTAICS
LA English
DT Article
DE antireflection; broad spectrum; omnidirectional; solar cells;
subwavelength
ID LOW-REFRACTIVE-INDEX; ANTIREFLECTION COATINGS; LARGE-SCALE; FILM; GAAS;
BAND; ENHANCEMENT; EFFICIENCY; DESIGN; ARRAYS
AB Reduction in surface and interface reflectance via the integration of subwavelength nanostructures in flexible polymer packaging material combined with incorporation of dielectric nanoislands into a conventional two-layer antireflection coating has been demonstrated, analyzed and optimized. Transmittance measurements of moth-eye textured polymer packaging sheets with different tapered pillar heights fabricated by reactive-ion etching and nanosphere lithography provide insights into the choice of the optimum nanostructure dimensions. Detailed computational modeling and simulations elucidate the physical nature of the antireflection performance of dielectric nanoisland structures integrated with a commercial two-layer antireflection coating, and provide guidance for design of the nanoisland structure for optimum antireflection performance. Measurements show that the integration of appropriately designed nanostructures in both polymer packaging material and conventional antireflection layers enables substantial increases in external quantum efficiency (E.Q.E.) and short-circuit current density (J(sc)) over a broad range of incident angles, compared to structures with conventional bilayer antireflection coatings and unpatterned polymer packaging sheets. A 1.1x increase in J(sc), derived directly from E.Q.E. measurements, at normal incidence, increasing to 1.67x improvement at 80 degrees angle of incidence, suggests that such an approach is promising for a variety of photovoltaic applications, particularly those where solar tracking is not feasible or practical. Copyright (C) 2014 John Wiley & Sons, Ltd.
C1 [Li, Xiaohan; Li, Ping-Chun; Ji, Li; Yu, Edward T.] Univ Texas Austin, Microelect Res Ctr, Austin, TX 78758 USA.
[Stender, Christopher; McPheeters, Claiborne; Tatavarti, Sudersena Rao] Microlink Devices Inc, Niles, IL 60714 USA.
[Sablon, Kimberly] US Army Res Lab, Adelphi, MD 20783 USA.
RP Yu, ET (reprint author), Univ Texas Austin, Elect & Comp Engn, 10100 Burnet Rd, Austin, TX 78758 USA.
EM ety@ece.utexas.edu
RI Yu, Edward/A-3515-2017
OI Yu, Edward/0000-0001-9900-7322
FU U.S. Army Research Laboratory; National Science Foundation
[ECCS-1120832, DMR-1311866]; Judson S. Swearingen Regents Chair in
Engineering at the University of Texas at Austin
FX Part of this work was supported by the U.S. Army Research Laboratory,
the National Science Foundation (ECCS-1120832 and DMR-1311866) and the
Judson S. Swearingen Regents Chair in Engineering at the University of
Texas at Austin. P.-C. Li would like to thank H.-H. Kung (Rutgers
University) and E.-S. Liu (UT-Austin) for fruitful discussions on
nanosphere lithography. X. H. Li and P. -C. Li contributed equally to
this work.
NR 38
TC 5
Z9 5
U1 5
U2 27
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1062-7995
EI 1099-159X
J9 PROG PHOTOVOLTAICS
JI Prog. Photovoltaics
PD OCT
PY 2015
VL 23
IS 10
BP 1398
EP 1405
DI 10.1002/pip.2565
PG 8
WC Energy & Fuels; Materials Science, Multidisciplinary; Physics, Applied
SC Energy & Fuels; Materials Science; Physics
GA CS3XI
UT WOS:000362008600021
ER
PT J
AU Nasar, F
Erasmus, JH
Haddow, AD
Tesh, RB
Weaver, SC
AF Nasar, Farooq
Erasmus, Jesse H.
Haddow, Andrew D.
Tesh, Robert B.
Weaver, Scott C.
TI Eilat virus induces both homologous and heterologous interference
SO VIROLOGY
LA English
DT Article
DE Alphavirus; Eilat virus; Superinfection
ID SEMLIKI-FOREST-VIRUS; HEPATITIS-C VIRUS; WEST NILE VIRUS;
INSECT-SPECIFIC FLAVIVIRUS; DISEASE VECTOR MOSQUITOS; AEDES-ALBOPICTUS
CELLS; AVIAN LEUKOSIS VIRUS; ROUS SARCOMA VIRUS; SUPERINFECTION
EXCLUSION; RNA INTERFERENCE
AB Most alphaviruses are mosquito-borne and exhibit a broad host range, infecting many different vertebrates including birds, rodents, equids, and humans. Occasionally, alphaviruses can spill over into the human population and cause disease characterized by debilitating arthralgia or fatal encephalitis. Recently, a unique alphavirus, Eilat virus (EILV), was described that readily infects mosquito but not vertebrate cell lines. Here, we investigated the ability of EILV to induce superinfection exclusion. Prior infection of C7/10 (Aedes albopictus) cells with EILV induced homologous and heterologous interference, reducing the virus titers of heterologous superinfecting viruses (SINV, VEEV, EEEV, WEEV, and CHIKV) by similar to 10-10,000 fold and delaying replication kinetics by 12-48 h. Similar to in vitro infection, prior in vivo EILV infection of Aedes aegypti mosquitoes delayed dissemination of chikungunya virus for 3 days. This is the first evidence of heterologous interference induced by a mosquito-specific alphavirus in vitro and in vivo. (C) 2015 Elsevier Inc. All rights. reserved.
C1 [Nasar, Farooq; Erasmus, Jesse H.; Tesh, Robert B.; Weaver, Scott C.] Univ Texas Med Branch, Inst Human Infect & Immun, Ctr Trop Dis, Galveston, TX 77555 USA.
[Nasar, Farooq; Erasmus, Jesse H.; Tesh, Robert B.; Weaver, Scott C.] Univ Texas Med Branch, Dept Pathol, Galveston, TX 77555 USA.
[Nasar, Farooq; Haddow, Andrew D.] US Army Med Res Inst Infect Dis, Div Virol, Frederick, MD 21702 USA.
RP Weaver, SC (reprint author), Univ Texas Med Branch, Inst Human Infect & Immun, Ctr Trop Dis, 301 Univ Blvd, Galveston, TX 77555 USA.
EM sweaver@utmb.edu
RI Weaver, Scott/D-6490-2011;
OI Haddow, Andrew/0000-0002-8957-2608; Erasmus, Jesse/0000-0003-1612-2697
FU National Institutes of Health [HHSN272201000040I/HHSN27200004/D04]
FX We thank Jing H. Huang for technical assistance with mosquito
experiments. This work was supported by National Institutes of Health
Contract HHSN272201000040I/HHSN27200004/D04 (to R.B.T.).
NR 76
TC 3
Z9 3
U1 0
U2 8
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0042-6822
J9 VIROLOGY
JI Virology
PD OCT
PY 2015
VL 484
BP 51
EP 58
DI 10.1016/j.virol.2015.05.009
PG 8
WC Virology
SC Virology
GA CR8CG
UT WOS:000361578100006
PM 26068885
ER
PT J
AU Prasitsuebsai, W
Kerr, SJ
Truong, KH
Ananworanich, J
Do, VC
Nguyen, LV
Kurniati, N
Kosalaraksa, P
Sudjaritruk, T
Chokephaibulkit, K
Thammajaruk, N
Singtoroj, T
Teeraananchai, S
Horng, H
Bacchetti, P
Gandhi, M
Sohn, AH
AF Prasitsuebsai, Wasana
Kerr, Stephen J.
Khanh Huu Truong
Ananworanich, Jintanat
Viet Chau Do
Lam Van Nguyen
Kurniati, Nia
Kosalaraksa, Pope
Sudjaritruk, Tavitiya
Chokephaibulkit, Kulkanya
Thammajaruk, Narukjaporn
Singtoroj, Thida
Teeraananchai, Sirinya
Horng, Howard
Bacchetti, Peter
Gandhi, Monica
Sohn, Annette H.
TI Using Lopinavir Concentrations in Hair Samples to Assess Treatment
Outcomes on Second-Line Regimens Among Asian Children
SO AIDS RESEARCH AND HUMAN RETROVIRUSES
LA English
DT Article
ID ANTIRETROVIRAL THERAPY ADHERENCE; LIQUID-CHROMATOGRAPHY; VIROLOGICAL
RESPONSE; SELF-REPORT; DRUGS; NEVIRAPINE; PLASMA
AB We conducted a prospective monitoring study to determine whether antiretroviral (ARV) levels in hair of Asian children on second-line protease inhibitor-based ARV therapy (ART) are associated with virologic failure (VF), compared to plasma drug levels and self-reported adherence. HIV-infected Asian children on second-line ART regimens were enrolled into a longitudinal cohort. Traditional adherence measures, plasma, and hair samples were collected 24 weeks after study enrollment. Hair ARV levels were determined via liquid chromatography/tandem mass spectrometry. Among 149 children on lopinavir/ritonavir-based regimens, 47% were female; the median [interquartile range (IQR)] age was 10.3 (7.9-13.3) years. The median CD4% was 26% (IQR 21.7-32.1%) and the median CD4 cell count 754 (IQR 596-1,013) cells/mm(3). The median duration of lopinavir-based ART prior to week 24 of the study was 2.9 (IQR 1.6-4.2) years. Adherence was >95% in 91% (135/148) by visual analogue scale and 89% (129/145) by pill count. The median lopinavir hair concentrations were 5.43 (IQR 3.21-9.01) ng/mg in children with HIV RNA >1,000 copies/ml and 9.96 (IQR 6.51-12.31) ng/mg in children with HIV RNA <1,000 copies/ml (p = 0.003). Plasma trough and lopinavir hair concentrations were not statistically significantly correlated (Pearson's correlation coefficient 0.20; p = 0.13). Increasing lopinavir hair concentrations in quartiles were strongly associated with virologic success (odds ratios >= 4.0, overall p = 0.02), while self-reported adherence, pill count, and plasma lopinavir levels were not. Based on this first report of hair ARV concentrations and virologic outcomes in children, ARV hair concentrations, representing longer-term adherence, may be useful to identify children at risk for VF.
C1 [Prasitsuebsai, Wasana; Kerr, Stephen J.; Thammajaruk, Narukjaporn; Teeraananchai, Sirinya] Thai Red Cross AIDS Res Ctr, HIV Netherlands Australia Thailand Res Collaborat, Bangkok, Thailand.
[Khanh Huu Truong] Childrens Hosp 1, Ho Chi Minh City, Vietnam.
[Ananworanich, Jintanat] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA.
[Ananworanich, Jintanat] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA.
[Viet Chau Do] Childrens Hosp 2, Ho Chi Minh City, Vietnam.
[Lam Van Nguyen] Natl Hosp Pediat, Hanoi, Vietnam.
[Kurniati, Nia] Cipto Mangunkusumo Gen Hosp, Jakarta, Indonesia.
[Kosalaraksa, Pope] Khon Kaen Univ, Dept Pediat, Div Infect Dis, Khon Kaen, Thailand.
[Sudjaritruk, Tavitiya] Chiang Mai Univ, Res Inst Hlth Sci, Chiang Mai 50000, Thailand.
[Sudjaritruk, Tavitiya] Chiang Mai Univ, Fac Med, Chiang Mai 50000, Thailand.
[Chokephaibulkit, Kulkanya] Mahidol Univ, Siriraj Hosp, Fac Med, Bangkok 10700, Thailand.
[Singtoroj, Thida; Sohn, Annette H.] TREAT Asia amfAR, Bangkok 10110, Thailand.
[Horng, Howard] Univ Calif San Francisco, Dept Bioengn & Therapeut Sci, San Francisco, CA 94143 USA.
[Bacchetti, Peter] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA.
[Gandhi, Monica] Univ Calif San Francisco, Dept Med, San Francisco, CA USA.
RP Sohn, AH (reprint author), TREAT Asia amfAR, 388 Sukhumvit Rd,Suite 2104, Bangkok 10110, Thailand.
EM annette.sohn@treatasia.org
FU TREAT Asia; program of amfAR; Foundation for AIDS Research; ViiV
Healthcare; U.S. National Institutes of Health's National Institute of
Allergy and Infectious Diseases; Eunice Kennedy Shriver National
Institute of Child Health and Human Development; National Cancer
Institute as part of the International Epidemiologic Databases to
Evaluate AIDS (IeDEA) [U01AI069907]; Austrian AIDS Life Association;
National Institutes of Allergy and Infectious Diseases (NIAID)/NIH [R01
AI098472]; Women's Interagency HIV Study [U01AI034989]
FX This study was funded by TREAT Asia, a program of amfAR, The Foundation
for AIDS Research, with support from ViiV Healthcare, the U.S. National
Institutes of Health's National Institute of Allergy and Infectious
Diseases (M. Gandhi and P. Bacchetti), Eunice Kennedy Shriver National
Institute of Child Health and Human Development, and National Cancer
Institute as part of the International Epidemiologic Databases to
Evaluate AIDS (IeDEA; U01AI069907), and the Austrian AIDS Life
Association. Partial support for hair assays came from the National
Institutes of Allergy and Infectious Diseases (NIAID)/NIH R01 AI098472
(M. Gandhi) and the Women's Interagency HIV Study (U01AI034989); we
would like to thank Dr. Leslie Z. Benet and Alexander Louie in the
laboratory for work on the hair assays. The content of this publication
is solely the responsibility of the authors and does not necessarily
represent the official views of any of the institutions mentioned above.
The authors would like to thank the participants and their families for
taking part in this study.
NR 26
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U1 1
U2 4
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0889-2229
EI 1931-8405
J9 AIDS RES HUM RETROV
JI Aids Res. Hum. Retrovir.
PD OCT 1
PY 2015
VL 31
IS 10
BP 1009
EP 1014
DI 10.1089/aid.2015.0111
PG 6
WC Immunology; Infectious Diseases; Virology
SC Immunology; Infectious Diseases; Virology
GA CR5PL
UT WOS:000361395500010
PM 26200586
ER
PT J
AU Bear, KA
Solomon, BD
AF Bear, Kelly A.
Solomon, Benjamin D.
TI GLI2 mutations typically result in pituitary anomalies with or without
postaxial polydactyly
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART A
LA English
DT Letter
ID HYPOPITUITARISM; PHENOTYPE
C1 [Bear, Kelly A.] Tripler Army Med Ctr, Dept Pediat, Honolulu, HI 96859 USA.
[Solomon, Benjamin D.] Inova Hlth Syst, Inova Translat Med Inst, Falls Church, VA USA.
[Solomon, Benjamin D.] Inova Hlth Syst, Inova Childrens Hosp, Falls Church, VA USA.
[Solomon, Benjamin D.] Virginia Commonwealth Univ, Sch Med, Dept Pediat, Richmond, VA USA.
RP Solomon, BD (reprint author), Inova Translat Med Inst, 3300 Gallows Rd Claude Moore Bldg,2nd Floor, Falls Church, VA 22042 USA.
EM benjamin.solomon@inova.org
NR 8
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1552-4825
EI 1552-4833
J9 AM J MED GENET A
JI Am. J. Med. Genet. A
PD OCT
PY 2015
VL 167
IS 10
BP 2491
EP 2492
DI 10.1002/ajmg.a.37160
PG 2
WC Genetics & Heredity
SC Genetics & Heredity
GA CR2TS
UT WOS:000361184100047
PM 25974718
ER
PT J
AU Kaldy, JE
Shafer, DJ
Ailstock, MS
Magoun, AD
AF Kaldy, James E.
Shafer, Deborah J.
Ailstock, M. Stephen
Magoun, A. Dale
TI Effects of temperature, salinity and seed age on induction of Zostera
japonica germination in North America, USA
SO AQUATIC BOTANY
LA English
DT Article
DE Zostera japonica; Seed germination; Introduced species
ID PARENT-OFFSPRING CONFLICT; GENETIC DIVERSITY; CHESAPEAKE BAY; MARINA L.;
EELGRASS; POPULATIONS; PATTERNS; CONSERVATION; RESTORATION; PERSISTENCE
AB Seagrasses can colonize unstructured mudflats either through clonal growth or seed germination and survival. Zostera japonica is an introduced seagrass in North America that has rapidly colonized mudflats along the Pacific Coast, leading to active management of the species. Growth and physiology have been evaluated; however, there is little information about the factors influencing seed germination. We examined the effects of storage and induction temperature (10, 15, 20 degrees C) and salinity (0, 10, 20, 30), and storage period (1.5 and 26 months) on germination of seeds of the seagrass Z. japonica collected from Yaquina Bay, Oregon, USA. Seed germination at 15 and 20 degrees C was 1.24 times higher than at 10 degrees C. Cumulative seed germination at salinity 0 during the first 28 days was 6.5 times greater than at a salinity of 10; similarly, initial seed germination at a salinity of 10 was 7.3 times greater than that observed for salinity 20 and 30. The proportion of germinated seeds collected in 2011 and stored for 26 months was 1.24 times greater than seeds collected in 2013 that were stored for only 6 weeks. Overall average germination rates were 21.6% and 17.1% for 2011 and 2013, respectively. Our experimental results indicate that salinity had a much stronger control over Z. japonica germination than temperature, and the long storage period suggests that Z. japonica is capable of developing a persistent seed bank. We hypothesize that Z. japonica uses seasonal variations in temperature and salinity to avoid competition between generations favoring germination under conditions that are not optimal for the growth of mature plants. Published by Elsevier B.V.
C1 [Kaldy, James E.] US EPA, Western Ecol Div, Newport, OR 97365 USA.
[Shafer, Deborah J.] Engn Res & Dev Ctr, Vicksburg, MS 39180 USA.
[Ailstock, M. Stephen] Anne Arundel Community Coll, Arnold, MD 21012 USA.
[Magoun, A. Dale] Appl Res & Anal Inc, Tallulah, LA 71284 USA.
RP Kaldy, JE (reprint author), US EPA, Western Ecol Div, 2111 SE Marine Sci Dr, Newport, OR 97365 USA.
EM Kaldy.Jim@epa.gov
NR 59
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Z9 2
U1 11
U2 74
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0304-3770
EI 1879-1522
J9 AQUAT BOT
JI Aquat. Bot.
PD OCT
PY 2015
VL 126
BP 73
EP 79
DI 10.1016/j.aquabot.2015.06.006
PG 7
WC Plant Sciences; Marine & Freshwater Biology
SC Plant Sciences; Marine & Freshwater Biology
GA CR3VM
UT WOS:000361261200010
ER
PT J
AU Wang, WY
Shang, SL
Wang, Y
Kim, H
Darling, KA
Kecskes, LJ
Mathaudhu, SN
Hui, XD
Liu, ZK
AF Wang, William Yi
Shang, Shun Li
Wang, Yi
Kim, Hongyeun
Darling, Kristopher A.
Kecskes, Laszlo J.
Mathaudhu, Suveen N.
Hui, Xi Dong
Liu, Zi-Kui
TI Solid-Solution Hardening in Mg-Gd-TM (TM = Ag, Zn, and Zr) Alloys: An
Integrated Density Functional Theory and Electron Work Function Study
SO JOM
LA English
DT Article
ID STACKING ORDERED STRUCTURES; TOTAL-ENERGY CALCULATIONS; WAVE BASIS-SET;
MAGNESIUM ALLOYS; HEXAGONAL STRUCTURE; ULTRAHIGH STRENGTH; ELASTIC
CONSTANTS; RE ALLOYS; METALS; PRECIPITATION
AB The current work aims to reveal the effects of solute atoms (TM = Ag, Zn, and Zr) on the age hardening of Mg-Gd-based alloys via the density functional theory and electron work function (EWF) approaches. The 10H LPSO phases of Mg-Gd-TM alloys are selected as the model case due to the improved strength and ductility such long periodic stacking ordered precipitates (LPSOs) offer. The CALPHAD-modeling method is applied to predict the EWF in the ternary Mg-Gd-TM alloys. The obtained EWFs of these Mg alloys are shown to match well with previous experimental and theoretical results. Moreover, the variation of EWF in the ternary Mg-Gd-TM alloys is attributed to the structure contribution [i.e., the formation of face-centered cubic (fcc)-type fault layers] and the chemical effect of solute atoms (i.e., electron redistributions). With the knowledge of bonding charge density between the solute and solvent atoms, the present work provides insight into the correlations between the EWF and hardness of Mg-Gd-TM alloys.
C1 [Wang, William Yi; Shang, Shun Li; Wang, Yi; Kim, Hongyeun; Liu, Zi-Kui] Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA.
[Darling, Kristopher A.; Kecskes, Laszlo J.] US Army, Res Lab, Weap & Mat Res Directorate, RDRL WMM B, Aberdeen Proving Ground, MD 21005 USA.
[Mathaudhu, Suveen N.] Univ Calif Riverside, Dept Mech Engn, Riverside, CA 92521 USA.
[Wang, William Yi; Hui, Xi Dong] Univ Sci & Technol Beijing, State Key Lab Adv Met & Mat, Beijing 100083, Peoples R China.
RP Wang, WY (reprint author), Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA.
EM yuw129@psu.edu
RI Wang, William Yi/F-8212-2011; Wang, Yi/D-1032-2013; Shang,
Shun-Li/A-6564-2009; Liu, Zi-Kui/A-8196-2009
OI Wang, William Yi/0000-0002-8814-525X; Shang,
Shun-Li/0000-0002-6524-8897; Liu, Zi-Kui/0000-0003-3346-3696
FU National Science Foundation [DMR-1006557]; U.S. Army Research Laboratory
in the Unites States [W911NF-08-2-0084]; National Natural Science
Foundation of China [50431030, 50871013]; Project Based Personnel
Exchange Program; American Academic Exchange Service; China Scholarship
Council [2008[3072]]; NSF [OCI-0821527, ACI-1053575]
FX The current work was financially supported by the National Science
Foundation (Grant No. DMR-1006557) and the U.S. Army Research Laboratory
(Project No. W911NF-08-2-0084) in the Unites States and National Natural
Science Foundation of China (50431030 and 50871013). W.Y. Wang
acknowledges the support from the Project Based Personnel Exchange
Program with American Academic Exchange Service and China Scholarship
Council (2008[3072]). First-principles calculations were carried out on
the LION clusters at the Pennsylvania State University supported by the
Materials Simulation Center and the Institute for CyberScience.
Calculations were also carried out on the CyberStar cluster funded by
the NSF through Grant No. OCI-0821527and the XSEDE clusters supported by
NSF through Grant ACI-1053575.
NR 70
TC 2
Z9 2
U1 17
U2 50
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1047-4838
EI 1543-1851
J9 JOM-US
JI JOM
PD OCT
PY 2015
VL 67
IS 10
BP 2433
EP 2441
DI 10.1007/s11837-015-1555-9
PG 9
WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical
Engineering; Mineralogy; Mining & Mineral Processing
SC Materials Science; Metallurgy & Metallurgical Engineering; Mineralogy;
Mining & Mineral Processing
GA CR6WO
UT WOS:000361489100040
ER
PT J
AU Pathak, CS
Teegavarapu, RSV
Olson, C
Singh, A
Lal, AMW
Polatel, C
Zahraeifard, V
Senarath, SUS
AF Pathak, Chandra S.
Teegavarapu, Ramesh S. V.
Olson, Chris
Singh, Abhishek
Lal, A. M. Wasantha
Polatel, Ceyda
Zahraeifard, Vahid
Senarath, Sharika U. S.
TI Uncertainty Analyses in Hydrologic/Hydraulic Modeling: Challenges and
Proposed Resolutions
SO JOURNAL OF HYDROLOGIC ENGINEERING
LA English
DT Article
ID PARAMETER-ESTIMATION; SPATIAL VARIABILITY; GROUNDWATER-FLOW; GLUE
METHODOLOGY; INPUT VARIABLES; SENSITIVITY; PREDICTION; DESIGN; ERRORS;
RISK
AB Forum papers are thought-provoking opinion pieces or essays founded in fact, sometimes containing speculation, on a civil engineering topic of general interest and relevance to the readership of the journal. The views expressed in this Forum article do not necessarily reflect the views of ASCE or the Editorial Board of the journal.
C1 [Pathak, Chandra S.] US Army Corps Engineers, Hydrol Hydraul & Coastal Community Practice, Washington, DC 20314 USA.
[Teegavarapu, Ramesh S. V.] Florida Atlantic Univ, Dept Civil Environm & Geomat Engn, Boca Raton, FL 33431 USA.
[Olson, Chris] Colorado State Univ, Dept Civil & Environm Engn, Ft Collins, CO 80523 USA.
[Singh, Abhishek] INTERA Inc, Austin, TX 78754 USA.
[Lal, A. M. Wasantha; Polatel, Ceyda] South Florida Water Management Dist, Hydraul & Hydrol Bur, W Palm Beach, FL 33406 USA.
[Zahraeifard, Vahid] Louisiana State Univ, Dept Civil & Environm Engn, Baton Rouge, LA 70803 USA.
[Senarath, Sharika U. S.] Berkshire Hathaway Specialty Insurance, Flood Peril Catastrophe Engn & Analyt, San Ramon, CA 94583 USA.
RP Pathak, CS (reprint author), US Army Corps Engineers, Hydrol Hydraul & Coastal Community Practice, 441 G St NW, Washington, DC 20314 USA.
EM chandra.s.pathak@usace.army.mil; rteegava@fau.edu;
colson23@engr.colostate.edu; asingh@intera.com; wlal@sfwmd.gov;
cpolatel@sfwmd.gov; v.zahraee@gmail.com;
Sharika.Senarath@bhspecialty.com
NR 82
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U1 4
U2 16
PU ASCE-AMER SOC CIVIL ENGINEERS
PI RESTON
PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA
SN 1084-0699
EI 1943-5584
J9 J HYDROL ENG
JI J. Hydrol. Eng.
PD OCT
PY 2015
VL 20
IS 10
DI 10.1061/(ASCE)HE.1943-5584.0001231
PG 11
WC Engineering, Civil; Environmental Sciences; Water Resources
SC Engineering; Environmental Sciences & Ecology; Water Resources
GA CR6TU
UT WOS:000361481300021
ER
PT J
AU Myaeng, J
Ong, B
Pinsker, JE
AF Myaeng, Jennifer
Ong, Bruce
Pinsker, Jordan E.
TI Hepatomegaly and Growth Failure in an 11-year-old Girl With Type 1
Diabetes
SO PEDIATRICS IN REVIEW
LA English
DT Editorial Material
C1 [Myaeng, Jennifer; Ong, Bruce] Tripler Army Med Ctr, Honolulu, HI 96859 USA.
[Pinsker, Jordan E.] William Sansum Diabet Ctr, Pediat, Santa Barbara, CA USA.
RP Myaeng, J (reprint author), Tripler Army Med Ctr, Honolulu, HI 96859 USA.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU AMER ACAD PEDIATRICS
PI ELK GROVE VILLAGE
PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA
SN 0191-9601
EI 1526-3347
J9 PEDIATR REV
JI Pediatr. Rev.
PD OCT
PY 2015
VL 36
IS 10
BP 459
EP 461
PG 3
WC Pediatrics
SC Pediatrics
GA DZ1UF
UT WOS:000385625700004
PM 26430206
ER
PT J
AU Aurora, A
Roe, JL
Corona, BT
Walters, TJ
AF Aurora, Amit
Roe, Janet L.
Corona, Benjamin T.
Walters, Thomas J.
TI An acellular biologic scaffold does not regenerate appreciable de novo
muscle tissue in rat models of volumetric muscle loss injury
SO BIOMATERIALS
LA English
DT Article
DE Muscle; Scaffold; ECM (extracellular matrix); Trauma; Animal model;
Volumetric muscle loss
ID SMALL-INTESTINAL SUBMUCOSA; EXTRACELLULAR-MATRIX SCAFFOLDS;
URINARY-BLADDER MATRIX; SKELETAL-MUSCLE; FUNCTIONAL RECOVERY; MURINE
MODEL; MACROPHAGE PHENOTYPE; INDUCTIVE SCAFFOLD; MEDICINE APPROACH;
REPAIR CONSTRUCT
AB Extracellular matrix (ECM) derived scaffolds continue to be investigated for the treatment of volumetric muscle loss (VML) injuries. Clinically, ECM scaffolds have been used for lower extremity VML repair; in particular, MatriStem (TM), a porcine urinary bladder matrix (UBM), has shown improved functional outcomes and vascularization, but limited myogenesis. However, efficacy of the scaffold for the repair of traumatic muscle injuries has not been examined systematically. In this study, we demonstrate that the porcine UBM scaffold when used to repair a rodent gastrocnemius musculotendinous junction (MTJ) and tibialis anterior (TA) VML injury does not support muscle tissue regeneration. In the MTJ model, the scaffold was completely resorbed without tissue remodeling, suggesting that the scaffold may not be suitable for the clinical repair of muscle-tendon injuries. In the TA VML injury, the scaffold remodeled into a fibrotic tissue and showed functional improvement, but not due to muscle fiber regeneration. The inclusion of physical rehabilitation also did not improve functional response or tissue remodeling. We conclude that the porcine UBM scaffold when used to treat VML injuries may hasten the functional recovery through the mechanism of scaffold mediated functional fibrosis. Thus for appreciable muscle regeneration, repair strategies that incorporate myogenic cells, vasculogenic accelerant and a myoconductive scaffold need to be developed. Published by Elsevier Ltd.
C1 [Aurora, Amit; Roe, Janet L.; Corona, Benjamin T.; Walters, Thomas J.] US Army, Inst Surg Res, Extrem Trauma & Regenerat Med, Ft Sam Houston, TX 78234 USA.
RP Walters, TJ (reprint author), US Army, Inst Surg Res, Extrem Trauma & Regenerat Med, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA.
EM thomas.j.walters22.civ@mail.mil
FU U.S. Army Institute of Surgical Research; ACell Inc., MD, USA; U.S. Army
Medical Research and Medical Command [W81XWH-09-2-0177]
FX Funding for the study and salary for Amit Aurora was provided under a
Cooperative Research and Development Agreement (CRADA) with U.S. Army
Institute of Surgical Research and ACell Inc., MD, USA awarded to TJW.
Part of this work was also funded by the U.S. Army Medical Research and
Medical Command (W81XWH-09-2-0177) awarded to TJW. All components of
this study including the decision to publish and where to publish were
the sole discretion of the authors. The opinions or assertions contained
herein are the private views of the authors and are not to be construed
as official or as reflecting the views of the Department of the Army or
the Department of Defense. The authors are employees of the United
States Government and this work was prepared as a part of their official
duties.
NR 58
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Z9 10
U1 1
U2 14
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0142-9612
EI 1878-5905
J9 BIOMATERIALS
JI Biomaterials
PD OCT
PY 2015
VL 67
BP 393
EP 407
DI 10.1016/j.biomaterials.2015.07.040
PG 15
WC Engineering, Biomedical; Materials Science, Biomaterials
SC Engineering; Materials Science
GA CR1IO
UT WOS:000361078600038
PM 26256250
ER
PT J
AU Grammer, PO
Mickle, PF
Peterson, MS
Havrylkoff, JM
Slack, WT
Leaf, RT
AF Grammer, Paul O.
Mickle, Paul F.
Peterson, Mark S.
Havrylkoff, Jeanne-Marie
Slack, William T.
Leaf, Robert T.
TI Activity patterns of Gulf Sturgeon (Acipenser oxyrinchus desotoi) in the
staging area of the Pascagoula River during fall outmigration
SO ECOLOGY OF FRESHWATER FISH
LA English
DT Article
DE migration; physiochemical cues; threatened species; rheotaxis
ID OF-MEXICO STURGEON; ESTUARINE TRANSITION ZONE; ATLANTIC STURGEON;
SUWANNEE RIVER; MOVEMENT PATTERNS; LAKE STURGEON; HABITAT USE;
MIGRATION; FLORIDA; WATER
AB Environmental cues that are associated with individual movement of threatened Gulf Sturgeon from upriver areas to nearshore and offshore winter feeding areas have been described throughout much of their range in the Gulf of Mexico. In this study, we focus on small-scale movement of Gulf Sturgeon between summer holding' areas and the fall staging area in the Pascagoula River system (Mississippi, USA). We evaluated a set of logistic regression models using Akaike's Information Criterion and found that relative changes in barometric pressure, time of day, and water temperature were cues for small-scale Gulf Sturgeon movements during fall outmigration. Numerous environmental cues appear to drive the activity of Gulf Sturgeon in staging areas, indicating the complexity of abiotic factors affecting the observed staging patterns during emigration. The identification of the environmental drivers that are associated with Gulf Sturgeon movement is particularly important if these known saline transition zones change spatially annually with variable rainfall or due to water withdrawals and are used by Gulf Sturgeon making osmotic adjustments while moving downriver.
C1 [Grammer, Paul O.; Mickle, Paul F.; Peterson, Mark S.; Havrylkoff, Jeanne-Marie; Leaf, Robert T.] Univ So Mississippi, Dept Coastal Sci, Ocean Springs, MS 39564 USA.
[Slack, William T.] US Army ERDC, Waterways Expt Stn EE A, Vicksburg, MS USA.
RP Grammer, PO (reprint author), Univ So Mississippi, Dept Coastal Sci, 703 E Beach Dr, Ocean Springs, MS 39564 USA.
EM paul.grammer@usm.edu
FU NOAA; NMFS Office of Protected Species; Gulf-wide Gulf Sturgeon survey
by U.S. Fish and Wildlife Service
FX This project was funded by NOAA, NMFS Office of Protected Species and a
Gulf-wide Gulf Sturgeon survey funded by U.S. Fish and Wildlife Service.
We thank M. Roberts, S. Bolden, G. Constant, and J. Schaefer for
technical and statistical assistance and M. Lowe, C. Newman, E.
Satterfield, B. Ennis, S. Ashworth, E. Lang, C. Thompson, B. Lewis, S.
George, A. Katzenmeyer, and B.J. Johnson for field and lab assistance.
This research was conducted under the USM Institute of Animal Care and
Use Committee #11092209 as well a scientific permit from Mississippi
Department of Wildlife, Fisheries, and Parks.
NR 46
TC 1
Z9 1
U1 0
U2 9
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0906-6691
EI 1600-0633
J9 ECOL FRESHW FISH
JI Ecol. Freshw. Fish
PD OCT
PY 2015
VL 24
IS 4
BP 553
EP 561
DI 10.1111/eff.12168
PG 9
WC Fisheries; Marine & Freshwater Biology
SC Fisheries; Marine & Freshwater Biology
GA CR0LP
UT WOS:000361010500006
ER
PT J
AU Clemens, MS
Aden, JK
Heafner, TA
Watson, JDB
Rasmussen, TE
Glasgow, SC
AF Clemens, Michael S.
Aden, James K.
Heafner, Thomas A.
Watson, J. Devin B.
Rasmussen, Todd E.
Glasgow, Sean C.
TI Quality of Life (QOL) in United States Veterans with Combat-Related
Ostomies from Iraq and Afghanistan
SO JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
LA English
DT Meeting Abstract
CT 70th Annual Sessions of the Scientific Forum and Annual Clinical
Congress of the American-College-of-Surgeons
CY OCT 04-08, 2015
CL Chicago, IL
SP Amer Coll Surg
C1 San Antonio Mil Med Ctr, San Antonio, TX USA.
US Air Force Ctr Sustainment Trauma, St Louis, MO USA.
US Army Inst Surg Res, San Antonio, TX USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1072-7515
EI 1879-1190
J9 J AM COLL SURGEONS
JI J. Am. Coll. Surg.
PD OCT
PY 2015
VL 221
IS 4
SU 1
BP S35
EP S35
PG 1
WC Surgery
SC Surgery
GA CR1XX
UT WOS:000361119700051
ER
PT J
AU Lawson, SD
Wang, LC
Fries, CA
Davis, MR
AF Lawson, Sharon D.
Wang, Lin C.
Fries, Charles A.
Davis, Michael R.
TI Hydrogen Sulfide Delays Onset of Acute Rejection in Porcine Vascularized
Composite Allotransplantation Model
SO JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
LA English
DT Meeting Abstract
CT 70th Annual Sessions of the Scientific Forum and Annual Clinical
Congress of the American-College-of-Surgeons
CY OCT 04-08, 2015
CL Chicago, IL
SP Amer Coll Surg
C1 [Lawson, Sharon D.; Wang, Lin C.; Fries, Charles A.; Davis, Michael R.] US Army Inst Surg Res, San Antonio, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1072-7515
EI 1879-1190
J9 J AM COLL SURGEONS
JI J. Am. Coll. Surg.
PD OCT
PY 2015
VL 221
IS 4
SU 1
BP S114
EP S114
PG 1
WC Surgery
SC Surgery
GA CR1XX
UT WOS:000361119700229
ER
PT J
AU Wang, LC
Lawson, SD
Villamaria, C
Fries, CA
Davis, MR
AF Wang, Lin C.
Lawson, Sharon D.
Villamaria, Carole
Fries, Charles A.
Davis, Michael R.
TI Hyperbaric Sub-Normothermic Perfusion Mitigates Reperfusion Injury in
Porcine Vascularized Composite Transplantation
SO JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
LA English
DT Meeting Abstract
CT 70th Annual Sessions of the Scientific Forum and Annual Clinical
Congress of the American-College-of-Surgeons
CY OCT 04-08, 2015
CL Chicago, IL
SP Amer Coll Surg
C1 [Wang, Lin C.; Lawson, Sharon D.; Villamaria, Carole; Fries, Charles A.; Davis, Michael R.] US Army Inst Surg Res, San Antonio, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1072-7515
EI 1879-1190
J9 J AM COLL SURGEONS
JI J. Am. Coll. Surg.
PD OCT
PY 2015
VL 221
IS 4
SU 1
BP S157
EP S158
PG 2
WC Surgery
SC Surgery
GA CR1XX
UT WOS:000361119700331
ER
PT J
AU Tuberville, TD
Andrews, KM
Sperry, JH
Grosse, AM
AF Tuberville, Tracey D.
Andrews, Kimberly M.
Sperry, Jinelle H.
Grosse, Andrew M.
TI Use of the NatureServe Climate Change Vulnerability Index as an
Assessment Tool for Reptiles and Amphibians: Lessons Learned
SO ENVIRONMENTAL MANAGEMENT
LA English
DT Article
DE Climate change; Vulnerability assessments; Reptiles; Amphibians; Sand
Hills ecoregion
ID ISOLATED WETLANDS; COASTAL-PLAIN; UNITED-STATES; ECTOTHERMS; DIVERSITY;
RICHNESS; HOTSPOT; RISK
AB Climate change threatens biodiversity globally, yet it can be challenging to predict which species may be most vulnerable. Given the scope of the problem, it is imperative to rapidly assess vulnerability and identify actions to decrease risk. Although a variety of tools have been developed to assess climate change vulnerability, few have been evaluated with regard to their suitability for certain taxonomic groups. Due to their ectothermic physiology, low vagility, and strong association with temporary wetlands, reptiles and amphibians may be particularly vulnerable relative to other groups. Here, we evaluate use of the NatureServe Climate Change Vulnerability Index (CCVI) to assess a large suite of herpetofauna from the Sand Hills Ecoregion of the southeastern United States. Although data were frequently lacking for certain variables (e.g., phenological response to climate change, genetic variation), sufficient data were available to evaluate all 117 species. Sensitivity analyses indicated that results were highly dependent on size of assessment area and climate scenario selection. In addition, several ecological traits common in, but relatively unique to, herpetofauna are likely to contribute to their vulnerability and need special consideration during the scoring process. Despite some limitations, the NatureServe CCVI was a useful tool for screening large numbers of reptile and amphibian species. We provide general recommendations as to how the CCVI tool's application to herpetofauna can be improved through more specific guidance to the user regarding how to incorporate unique physiological and behavioral traits into scoring existing sensitivity factors and through modification to the assessment tool itself.
C1 [Tuberville, Tracey D.; Andrews, Kimberly M.; Grosse, Andrew M.] Univ Georgia, Savannah River Ecol Lab, Aiken, SC 29802 USA.
[Andrews, Kimberly M.] Georgia Sea Turtle Ctr, Jekyll Isl Author, Jekyll Isl, GA 31527 USA.
[Sperry, Jinelle H.] Engn Res & Dev Ctr, Champaign, IL 61826 USA.
[Sperry, Jinelle H.] Univ Illinois, Dept Nat Resources & Environm Sci, Urbana, IL 61801 USA.
[Grosse, Andrew M.] Marine Resources Res Inst, South Carolina Dept Nat Resources, Charleston, SC 29412 USA.
RP Tuberville, TD (reprint author), Univ Georgia, Savannah River Ecol Lab, Aiken, SC 29802 USA.
EM tubervil@uga.edu
FU U.S. Army Construction Engineering Research Laboratory
[W9132T-11-2-0009]; Department of Energy to the University of Georgia
Research Foundation [DE-FC09-07SR22506]
FX We would like to thank James Westervelt and Tim Hayden for their
guidance throughout the project. Discussions with Bruce Young provided
the impetus to develop this manuscript. We thank Bess Harris for
assistance with the supplemental scoring and Alex Fillak for assistance
with the climate scenario sensitivity analysis. Funding was provided by
Award #W9132T-11-2-0009 from the U.S. Army Construction Engineering
Research Laboratory and Award #DE-FC09-07SR22506 from Department of
Energy to the University of Georgia Research Foundation.
NR 67
TC 1
Z9 1
U1 8
U2 57
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0364-152X
EI 1432-1009
J9 ENVIRON MANAGE
JI Environ. Manage.
PD OCT
PY 2015
VL 56
IS 4
BP 822
EP 834
DI 10.1007/s00267-015-0537-6
PG 13
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA CQ6GR
UT WOS:000360703100004
PM 25971738
ER
PT J
AU Lin, YX
Donetsky, D
Wang, D
Westerfeld, D
Kipshidze, G
Shterengas, L
Sarney, WL
Svensson, SP
Belenky, G
AF Lin, Youxi
Donetsky, Dmitry
Wang, Ding
Westerfeld, David
Kipshidze, Gela
Shterengas, Leon
Sarney, Wendy L.
Svensson, Stefan P.
Belenky, Gregory
TI Development of Bulk InAsSb Alloys and Barrier Heterostructures for
Long-Wave Infrared Detectors
SO JOURNAL OF ELECTRONIC MATERIALS
LA English
DT Article
DE InAsSb; energy gap bowing; long-wave infrared; barrier photodetector
ID BEAM EPITAXIAL-GROWTH; SUPERLATTICES; INAS1-XSBX; INSB
AB Bulk unrelaxed InAsSb alloys with Sb compositions up to 65% were grown on compositionally graded GaInSb and AlInSb buffers on GaSb substrates by molecular beam epitaxy. The minimum energy gap for these materials at T = 77 K was estimated to be 90 meV. Benchmark material parameters were measured for barrier photodetector heterostructures with 1-mu m-thick InAs0.6Sb0.4 absorbers. A minority hole lifetime of 185 ns and a diffusion length of 9 mu m at T = 77 K were determined from the transient response of barrier heterostructures. The data imply a hole mobility of 10(3) cm(2)/Vs, which was confirmed with frequency response measurements. A 100-mu m square mesa contact nBn heterostructure demonstrated a -3 dB frequency response bandwidth of 50 MHz.
C1 [Lin, Youxi; Donetsky, Dmitry; Wang, Ding; Westerfeld, David; Kipshidze, Gela; Shterengas, Leon; Belenky, Gregory] SUNY Stony Brook, Dept ECE, Stony Brook, NY 11794 USA.
[Sarney, Wendy L.; Svensson, Stefan P.] US Army, Res Lab, Adelphi, MD 20783 USA.
RP Lin, YX (reprint author), SUNY Stony Brook, Dept ECE, Stony Brook, NY 11794 USA.
EM youxi.lin@stonybrook.edu
OI LIN, YOUXI/0000-0002-9092-2302
FU US Army Research Office [W911NF1220057]; US National Science Foundation
[DMR1160843]
FX The work was supported by US Army Research Office through Award
W911NF1220057 and by US National Science Foundation through Grant No.
DMR1160843.
NR 21
TC 2
Z9 2
U1 6
U2 30
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0361-5235
EI 1543-186X
J9 J ELECTRON MATER
JI J. Electron. Mater.
PD OCT
PY 2015
VL 44
IS 10
BP 3360
EP 3366
DI 10.1007/s11664-015-3892-4
PG 7
WC Engineering, Electrical & Electronic; Materials Science,
Multidisciplinary; Physics, Applied
SC Engineering; Materials Science; Physics
GA CQ5VD
UT WOS:000360672900022
ER
PT J
AU Connor, JH
Yen, J
Caballero, IS
Garamszegi, S
Malhotra, S
Lin, K
Hensley, L
Goff, AJ
AF Connor, John H.
Yen, Judy
Caballero, Ignacio S.
Garamszegi, Sara
Malhotra, Shikha
Lin, Kenny
Hensley, Lisa
Goff, Arthur J.
TI Transcriptional Profiling of the Immune Response to Marburg Virus
Infection
SO JOURNAL OF VIROLOGY
LA English
DT Article
ID VIRAL HEMORRHAGIC-FEVER; CYNOMOLGUS MACAQUES; GENE-EXPRESSION; EBOLA
VIRUSES; DISEASE; PATHOGENESIS; ANGOLA; CELLS; MONOCYTES; OUTBREAK
AB Marburg virus is a genetically simple RNA virus that causes a severe hemorrhagic fever in humans and nonhuman primates. The mechanism of pathogenesis of the infection is not well understood, but it is well accepted that pathogenesis is appreciably driven by a hyperactive immune response. To better understand the overall response to Marburg virus challenge, we undertook a transcriptomic analysis of immune cells circulating in the blood following aerosol exposure of rhesus macaques to a lethal dose of Marburg virus. Using two-color microarrays, we analyzed the transcriptomes of peripheral blood mononuclear cells that were collected throughout the course of infection from 1 to 9 days postexposure, representing the full course of the infection. The response followed a 3-stage induction (early infection, 1 to 3 days postexposure; midinfection, 5 days postexposure; late infection, 7 to 9 days postexposure) that was led by a robust innate immune response. The host response to aerosolized Marburg virus was evident at 1 day postexposure. Analysis of cytokine transcripts that were overexpressed during infection indicated that previously unanalyzed cytokines are likely induced in response to exposure to Marburg virus and further suggested that the early immune response is skewed toward a Th2 response that would hamper the development of an effective antiviral immune response early in disease. Late infection events included the upregulation of coagulation-associated factors. These findings demonstrate very early host responses to Marburg virus infection and provide a rich data set for identification of factors expressed throughout the course of infection that can be investigated as markers of infection and targets for therapy.
IMPORTANCE
Marburg virus causes a severe infection that is associated with high mortality and hemorrhage. The disease is associated with an immune response that contributes to the lethality of the disease. In this study, we investigated how the immune cells circulating in the blood of infected primates respond following exposure to Marburg virus. Our results show that there are three discernible stages of response to infection that correlate with presymptomatic, early, and late symptomatic stages of infection, a response format similar to that seen following challenge with other hemorrhagic fever viruses. In contrast to the ability of the virus to block innate immune signaling in vitro, the earliest and most sustained response is an interferon-like response. Our analysis also identifies a number of cytokines that are transcriptionally upregulated during late stages of infection and suggest that there is a Th2-skewed response to infection. When correlated with companion data describing the animal model from which our samples were collected, our results suggest that the innate immune response may contribute to overall pathogenesis.
C1 [Connor, John H.; Yen, Judy; Caballero, Ignacio S.; Garamszegi, Sara; Malhotra, Shikha] Boston Univ, Sch Med, Dept Microbiol, Boston, MA 02118 USA.
[Connor, John H.; Yen, Judy; Caballero, Ignacio S.; Garamszegi, Sara; Malhotra, Shikha] Natl Emerging Infect Dis Lab, Boston, MA USA.
[Lin, Kenny; Hensley, Lisa; Goff, Arthur J.] US Army, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
RP Connor, JH (reprint author), Boston Univ, Sch Med, Dept Microbiol, Boston, MA 02118 USA.
EM jhconnor@bu.edu
OI Connor, John/0000-0002-8867-7256
FU [W81XWH 100-02-0008]; [11-02-0130]
FX This work was supported by contracts W81XWH 100-02-0008 and 11-02-0130.
NR 41
TC 6
Z9 6
U1 2
U2 30
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0022-538X
EI 1098-5514
J9 J VIROL
JI J. Virol.
PD OCT
PY 2015
VL 89
IS 19
BP 9865
EP 9874
DI 10.1128/JVI.01142-15
PG 10
WC Virology
SC Virology
GA CQ6HJ
UT WOS:000360704900017
PM 26202234
ER
PT J
AU Lin, KL
Twenhafel, NA
Connor, JH
Cashman, KA
Shamblin, JD
Donnelly, GC
Esham, HL
Wlazlowski, CB
Johnson, JC
Honko, AN
Botto, MA
Yen, J
Hensley, LE
Goff, AJ
AF Lin, Kenny L.
Twenhafel, Nancy A.
Connor, John H.
Cashman, Kathleen A.
Shamblin, Joshua D.
Donnelly, Ginger C.
Esham, Heather L.
Wlazlowski, Carly B.
Johnson, Joshua C.
Honko, Anna N.
Botto, Miriam A.
Yen, Judy
Hensley, Lisa E.
Goff, Arthur J.
TI Temporal Characterization of Marburg Virus Angola Infection following
Aerosol Challenge in Rhesus Macaques
SO JOURNAL OF VIROLOGY
LA English
DT Article
ID HEMORRHAGIC-FEVER; CYNOMOLGUS MACAQUES; EBOLA; PATHOGENESIS;
FILOVIRUSES; PROTECTION; RESPONSES; OUTBREAK; MONKEYS; DISEASE
AB Marburg virus (MARV) infection is a lethal hemorrhagic fever for which no licensed vaccines or therapeutics are available. Development of appropriate medical countermeasures requires a thorough understanding of the interaction between the host and the pathogen and the resulting disease course. In this study, 15 rhesus macaques were sequentially sacrificed following aerosol exposure to the MARV variant Angola, with longitudinal changes in physiology, immunology, and histopathology used to assess disease progression. Immunohistochemical evidence of infection and resulting histopathological changes were identified as early as day 3 postexposure (p.e.). The appearance of fever in infected animals coincided with the detection of serum viremia and plasma viral genomes on day 4 p.e. High (> 10(7) PFU/ml) viral loads were detected in all major organs (lung, liver, spleen, kidney, brain, etc.) beginning day 6 p.e. Clinical pathology findings included coagulopathy, leukocytosis, and profound liver destruction as indicated by elevated liver transaminases, azotemia, and hypoalbuminemia. Altered cytokine expression in response to infection included early increases in Th2 cytokines such as interleukin 10 (IL-10) and IL-5 and late-stage increases in Th1 cytokines such as IL-2, IL-15, and granulocyte-macrophage colony-stimulating factor (GM-CSF). This study provides a longitudinal examination of clinical disease of aerosol MARV Angola infection in the rhesus macaque model.
IMPORTANCE
In this study, we carefully analyzed the timeline of Marburg virus infection in nonhuman primates in order to provide a well-characterized model of disease progression following aerosol exposure.
C1 [Lin, Kenny L.; Twenhafel, Nancy A.; Cashman, Kathleen A.; Shamblin, Joshua D.; Donnelly, Ginger C.; Esham, Heather L.; Wlazlowski, Carly B.; Johnson, Joshua C.; Honko, Anna N.; Botto, Miriam A.; Hensley, Lisa E.; Goff, Arthur J.] US Army, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
[Connor, John H.; Yen, Judy] Boston Univ, Sch Med, Boston, MA 02118 USA.
[Connor, John H.; Yen, Judy] Natl Emerging Infect Dis Lab, Boston, MA USA.
[Johnson, Joshua C.; Honko, Anna N.; Hensley, Lisa E.] NIAID, Integrated Res Facil, Ft Detrick, MD USA.
RP Goff, AJ (reprint author), US Army, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
EM arthur.j.goff.civ@mail.mil
OI Connor, John/0000-0002-8867-7256; Honko, Anna/0000-0001-9165-148X
FU TMTI under USAMRIID project [195732]
FX This research was funded by TMTI under USAMRIID project number 195732.
NR 31
TC 6
Z9 6
U1 1
U2 16
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0022-538X
EI 1098-5514
J9 J VIROL
JI J. Virol.
PD OCT
PY 2015
VL 89
IS 19
BP 9875
EP 9885
DI 10.1128/JVI.01147-15
PG 11
WC Virology
SC Virology
GA CQ6HJ
UT WOS:000360704900018
PM 26202230
ER
PT J
AU Cheng, H
Lear-Rooney, CM
Johansen, L
Varhegyi, E
Chen, ZW
Olinger, GG
Rong, LJ
AF Cheng, Han
Lear-Rooney, Calli M.
Johansen, Lisa
Varhegyi, Elizabeth
Chen, Zheng W.
Olinger, Gene G.
Rong, Lijun
TI Inhibition of Ebola and Marburg Virus Entry by G Protein-Coupled
Receptor Antagonists
SO JOURNAL OF VIROLOGY
LA English
DT Article
ID NIEMANN-PICK C1; NONHUMAN-PRIMATES; CELL ENTRY; GLYCOSAMINOGLYCANS;
INFECTION; TARGETS; DISEASE
AB Filoviruses, consisting of Ebola virus (EBOV) and Marburg virus (MARV), are among the most lethal infectious threats to mankind. Infections by these viruses can cause severe hemorrhagic fevers in humans and nonhuman primates with high mortality rates. Since there is currently no vaccine or antiviral therapy approved for humans, there is an urgent need to develop prophylactic and therapeutic options for use during filoviral outbreaks and bioterrorist attacks. One of the ideal targets against filoviral infection and diseases is at the entry step, which is mediated by the filoviral glycoprotein (GP). In this report, we screened a chemical library of small molecules and identified numerous inhibitors, which are known G protein-coupled receptor (GPCR) antagonists targeting different GPCRs, including histamine receptors, 5-HT (serotonin) receptors, muscarinic acetylcholine receptor, and adrenergic receptor. These inhibitors can effectively block replication of both infectious EBOV and MARV, indicating a broad antiviral activity of the GPCR antagonists. The time-of-addition experiment and microscopic studies suggest that GPCR antagonists block filoviral entry at a step following the initial attachment but prior to viral/cell membrane fusion. These results strongly suggest that GPCRs play a critical role in filoviral entry and GPCR antagonists can be developed as an effective anti-EBOV/MARV therapy.
IMPORTANCE
Infection of Ebola virus and Marburg virus can cause severe illness in humans with a high mortality rate, and currently there is no FDA-approved vaccine or therapeutic treatment available. The 2013-2015 epidemic in West Africa underscores a lack of our understanding in the infection and pathogenesis of these viruses and the urgency of drug discovery and development. In this study, we have identified numerous inhibitors that are known G protein-coupled receptor (GPCR) antagonists targeting different GPCRs. These inhibitors can effectively block replication of both infectious EBOV and MARV, indicating a broad antiviral activity of the GPCR antagonists. Our results strongly suggest that GPCRs play a critical role in filoviral entry and GPCR antagonists can be developed as an effective anti-EBOV/MARV therapy.
C1 [Cheng, Han; Varhegyi, Elizabeth; Chen, Zheng W.; Rong, Lijun] Univ Illinois, Coll Med, Dept Microbiol & Immunol, Chicago, IL 60612 USA.
[Lear-Rooney, Calli M.; Olinger, Gene G.] US Army, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
[Johansen, Lisa] Horizon Discovery Inc, Cambridge, MA USA.
RP Rong, LJ (reprint author), Univ Illinois, Coll Med, Dept Microbiol & Immunol, Chicago, IL 60612 USA.
EM lijun@uic.edu
FU National Institutes of Health (USA) grant [AI77767]; DTRA project
[4.10007_08_RD_B, W81XWH-08-0051]
FX This research was partially supported by National Institutes of Health
(USA) grant AI77767 to L.R. USAMRIID efforts were supported by DTRA
project 4.10007_08_RD_B, awarded to G.G.O., and subcontract
W81XWH-08-0051, awarded to L.J.
NR 26
TC 7
Z9 7
U1 2
U2 69
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0022-538X
EI 1098-5514
J9 J VIROL
JI J. Virol.
PD OCT
PY 2015
VL 89
IS 19
BP 9932
EP 9938
DI 10.1128/JVI.01337-15
PG 7
WC Virology
SC Virology
GA CQ6HJ
UT WOS:000360704900023
PM 26202243
ER
PT J
AU Tschopp, M
Cormier, J
Feng, Q
Evans, JL
AF Tschopp, M.
Cormier, J.
Feng, Q.
Evans, J. L.
TI Multiscale Microstructure, Mechanics, and Prognosis of High Temperature
Alloys Foreword
SO METALLURGICAL AND MATERIALS TRANSACTIONS A-PHYSICAL METALLURGY AND
MATERIALS SCIENCE
LA English
DT Editorial Material
C1 [Tschopp, M.] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA.
[Cormier, J.] Ecole Natl Super Mecan & Aerotech, ISAE ENSMA, F-86961 Futuroscope, France.
[Cormier, J.] UPR CNRS 3346, Insitut Pprime, F-86961 Futuroscope, France.
[Feng, Q.] Univ Sci & Technol Beijing, Beijing 100083, Peoples R China.
[Evans, J. L.] Univ Alabama, Huntsville, AL 35899 USA.
RP Tschopp, M (reprint author), US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA.
EM mark.a.tschopp.civ@mail.mil
OI Tschopp, Mark/0000-0001-8471-5035
NR 4
TC 0
Z9 0
U1 1
U2 5
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1073-5623
EI 1543-1940
J9 METALL MATER TRANS A
JI Metall. Mater. Trans. A-Phys. Metall. Mater. Sci.
PD OCT
PY 2015
VL 46A
IS 10
BP 4587
EP 4588
DI 10.1007/s11661-015-2992-3
PG 2
WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical
Engineering
SC Materials Science; Metallurgy & Metallurgical Engineering
GA CQ4EX
UT WOS:000360558200020
ER
PT J
AU Tschopp, MA
Miller, JD
Oppedal, AL
Solanki, KN
AF Tschopp, Mark A.
Miller, Jonathan D.
Oppedal, Andrew L.
Solanki, Kiran N.
TI Evaluating Local Primary Dendrite Arm Spacing Characterization
Techniques Using Synthetic Directionally Solidified Dendritic
Microstructures
SO METALLURGICAL AND MATERIALS TRANSACTIONS A-PHYSICAL METALLURGY AND
MATERIALS SCIENCE
LA English
DT Article
ID NICKEL-BASED SUPERALLOYS; HIGH MAGNETIC-FIELD; NI-BASED SUPERALLOY; BASE
SUPERALLOYS; ALLOYS; SEGREGATION; MORPHOLOGY; VARIABLES; FEATURES
AB Microstructure characterization continues to play an important bridge to understanding why particular processing routes or parameters affect the properties of materials. This statement certainly holds true in the case of directionally solidified dendritic microstructures, where characterizing the primary dendrite arm spacing is vital to developing the process-structure-property relationships that can lead to the design and optimization of processing routes for defined properties. In this work, four series of simulations were used to examine the capability of a few Voronoi-based techniques to capture local microstructure statistics (primary dendrite arm spacing and coordination number) in controlled (synthetically generated) microstructures. These simulations used both cubic and hexagonal microstructures with varying degrees of disorder (noise) to study the effects of length scale, base microstructure, microstructure variability, and technique parameters on the local PDAS distribution, local coordination number distribution, bulk PDAS, and bulk coordination number. The Voronoi tesselation technique with a polygon-side-length criterion correctly characterized the known synthetic microstructures. By systematically studying the different techniques for quantifying local primary dendrite arm spacings, we have evaluated their capability to capture this important microstructure feature in different dendritic microstructures, which can be an important step for experimentally correlating with both processing and properties in single crystal nickel-based superalloys.
C1 [Tschopp, Mark A.] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA.
[Miller, Jonathan D.] Air Force Res Lab, Wright Patterson AFB, OH 45433 USA.
[Oppedal, Andrew L.] Mississippi State Univ, Ctr Adv Vehicular Syst, Mississippi State, MS 39762 USA.
[Solanki, Kiran N.] Arizona State Univ, Sch Engn Matter Transport & Energy, Tempe, AZ 85287 USA.
RP Tschopp, MA (reprint author), US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA.
EM mark.a.tschopp.civ@mail.mil
RI Solanki, Kiran/E-8337-2010;
OI Tschopp, Mark/0000-0001-8471-5035
FU AFOSR [FA9550-12-1-0135]
FX The authors would like to acknowledge AFOSR for support for this
research through contract FA9550-12-1-0135 (PM: Dr. David Stargel,
AFOSR/RSA). The authors would like to acknowledge initial discussions
with M. Groeber (Air Force Research Laboratory) in the beginning stages
of this project. Additionally, the authors acknowledge R. Carino (Center
for Advanced Vehicular Systems, Mississippi State University) for
helping implement the scripts utilized herein into a more user-friendly
GUI environment.
NR 36
TC 2
Z9 2
U1 6
U2 18
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1073-5623
EI 1543-1940
J9 METALL MATER TRANS A
JI Metall. Mater. Trans. A-Phys. Metall. Mater. Sci.
PD OCT
PY 2015
VL 46A
IS 10
BP 4610
EP 4628
DI 10.1007/s11661-015-2964-7
PG 19
WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical
Engineering
SC Materials Science; Metallurgy & Metallurgical Engineering
GA CQ4EX
UT WOS:000360558200023
ER
PT J
AU Klacka, J
Kocifaj, M
Kundracik, F
Videen, G
AF Klacka, Jozef
Kocifaj, Miroslav
Kundracik, Frantisek
Videen, Gorden
TI Optical signatures of electrically charged particles: Fundamental
problems and solutions
SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER
LA English
DT Article
DE Electromagnetic scattering; Charged particles; Surface current density;
Separation-of-variables method
ID ELECTROMAGNETIC-WAVES; RAYLEIGH APPROXIMATION; DUST PARTICLES;
SCATTERING; NANOPARTICLES; SPHERES; SAND
AB The explicit solution to Maxwell's equations that satisfies the continuity equation is obtained for electrically charged spherical particles. The traditional separation-of-variables method (SVM) cannot be used to solve the vector wave equation for a non-uniformly charged spherical particle. In addition, a perturbation approach to the electromagnetic scattering problem fails if a spherical particle is occupied by electric charges that are not spatially homogeneous. By incorporating a correction to the conventional surface-current density, we have refined the conductivity model and found that the Rayleigh approximation (for mode n=1) is not a valid approach for modelling the optical effects by electrically charged particles much smaller than the wavelength of an incident radiation. Theoretical analyses indicate that peak enhancements of optical signatures are usually relevant in the long-wavelength limit due to the necessity to include higher-order modes of vibration (n>1). (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Klacka, Jozef; Kocifaj, Miroslav; Kundracik, Frantisek] Comenius Univ, Fac Math Phys & Informat, Bratislava 84248, Slovakia.
[Kocifaj, Miroslav] Slovak Acad Sci, ICA, Bratislava 84503, Slovakia.
[Videen, Gorden] INTA, Madrid 28850, Spain.
[Videen, Gorden] Univ Cantabria, Fac Ciencias, Dept Fis Aplicada, Grp Opt, E-39005 Santander, Spain.
[Videen, Gorden] AMSRD ARL CI ES, US Army Res Lab, Adelphi, MD 20783 USA.
RP Kocifaj, M (reprint author), Comenius Univ, Fac Math Phys & Informat, Bratislava 84248, Slovakia.
EM klacka@fmph.uniba.sk; kocifaj@savba.sk; kundracik@fmph.uniba.sk;
gorden.w.videen.civ@mail.mil
FU US Army International Technology Center (RD) [W911NF-14-1-0601,
1695-PH-01]; Slovak National Grant Agency VEGA [2/0002/12, 1/067/13]
FX This work was supported by the US Army International Technology Center
under the Contract no: W911NF-14-1-0601 (R&D 1695-PH-01). Computational
work was supported by the Slovak National Grant Agency VEGA (Grants nos.
2/0002/12 and 1/067/13).
NR 25
TC 6
Z9 6
U1 2
U2 8
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-4073
EI 1879-1352
J9 J QUANT SPECTROSC RA
JI J. Quant. Spectrosc. Radiat. Transf.
PD OCT
PY 2015
VL 164
BP 45
EP 53
DI 10.1016/j.jqsrt.2015.05.009
PG 9
WC Optics; Spectroscopy
SC Optics; Spectroscopy
GA CO9NL
UT WOS:000359502400004
ER
PT J
AU Beaudet, TD
Smith, JR
Adams, JW
AF Beaudet, Todd D.
Smith, John R.
Adams, Jane W.
TI Surface energy and relaxation in boron carbide (10(1)over-bar1) from
first principles
SO SOLID STATE COMMUNICATIONS
LA English
DT Article
DE Surface energy; Work of separation; Fracture; Density functional theory
ID GENERALIZED-GRADIENT APPROXIMATION; SPACE GAUSSIAN PSEUDOPOTENTIALS;
MECHANICAL-PROPERTIES; CERAMICS; EXCHANGE; FRACTURE; B4C
AB The surface energy of the boron carbide polytype B11Cp(CBC) for planar separations along {10 (1) over bar1} was determined to be 3.21 J/m(2) via first-principles density-functional computations. Surface atomic relaxations are relatively large, thereby lowering the surface energy significantly. The icosahedra are not intact on the surface, i.e., severed polyhedra are the lowest energy surface configuration. Good agreement was found with an experimental average fracture surface energy. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Beaudet, Todd D.; Adams, Jane W.] US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
[Smith, John R.] Univ Michigan, Dept Mat Sci & Engn, Ann Arbor, MI 48109 USA.
[Smith, John R.] Johns Hopkins Univ, Dept Mech Engn, Baltimore, MD 21218 USA.
RP Beaudet, TD (reprint author), US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
EM todd.d.beaudet.ctr@mail.mil
FU U.S. Army Research Laboratory
FX T.D. Beaudet thankfully acknowledges that this research was supported in
part by an appointment to the Postgraduate Research Participation
Program at the U.S. Army Research Laboratory (USARL) administered by the
Oak Ridge Institute for Science and Education through an interagency
agreement between the U.S. Department of Energy and USARL (proposal
1120-1120-99). J.R. Smith gratefully acknowledges partial support from
the U.S. Army Research Laboratory. Useful comments from J. McCauley, J.
LaSalvia, J. Swab, and K. Hemker are especially appreciated.
NR 29
TC 3
Z9 3
U1 0
U2 13
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0038-1098
EI 1879-2766
J9 SOLID STATE COMMUN
JI Solid State Commun.
PD OCT
PY 2015
VL 219
BP 43
EP 47
DI 10.1016/j.ssc.2015.06.021
PG 5
WC Physics, Condensed Matter
SC Physics
GA CO5BW
UT WOS:000359175600010
ER
PT J
AU Brooks, J
Kerick, S
AF Brooks, Justin
Kerick, Scott
TI Event-related alpha perturbations related to the scaling of steering
wheel corrections
SO PHYSIOLOGY & BEHAVIOR
LA English
DT Article
DE Visuomotor; Sensorimotor; Alertness; Driving; Steering wheel; ERSP
ID INDEPENDENT COMPONENT ANALYSIS; MU-RHYTHM; SUSTAINED-ATTENTION; VISUAL
FEEDBACK; EEG; DYNAMICS; DESYNCHRONIZATION; SYNCHRONIZATION; POWER; PATH
AB Previously we derived a new measure relating the driver's steering wheel responses to the vehicle's heading error velocity. This measure, the relative steering wheel compensation (RSWC), changes at times coincident with an alerting stimulus, possibly representing shifts in control strategy as measured by a change in the gain between visual input and motor output. In the present study, we sought to further validate this novel measure by determining the relationship between the RSWC and electroencephalogram (EEG) activity in brain regions associated with sensorimotor transformation processes. These areas have been shown to exhibit event-related spectral perturbation (ERSP) in the alpha frequency band that occurs with the onset of corrective steering wheel maneuvers in response to vehicle perturbations. We hypothesized that these regions would show differential alpha activity depending on whether the RSWC was high or low, reflecting changes in gain between visual input and motor output. Interestingly, we find that low RSWC is associated with significantly less peak desynchronization than larger RSWC. In addition we demonstrate that these differences are not attributable to the amount the steering wheel is turned nor the heading error velocity independently. Collectively these results suggest that neural activity in these sensorimotor regions scales with alertness and may represent differential utilization of multisensory information to control the steering wheel. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
C1 [Brooks, Justin; Kerick, Scott] US Army Res Lab, Translat Neurosci Branch, RDRL HRSC ARL HRED TNB, Aberdeen Proving Ground, MD 21005 USA.
RP Brooks, J (reprint author), US Army Res Lab, Translat Neurosci Branch, RDRL HRSC ARL HRED TNB, 459 Mulberry Point Rd, Aberdeen Proving Ground, MD 21005 USA.
EM justin.brooks12.civ@mail.mil; scott.e.kerick.civ@mail.mil
FU Army Research Laboratory [W911NF-12-20019]; Office of the Secretary of
Defense Autonomy Research Pilot Initiative program [MIPR DWAM31168]
FX The research was sponsored by the Army Research Laboratory and was
accomplished in part under Cooperative Agreement Number W911NF-12-20019
and in part by the Office of the Secretary of Defense Autonomy Research
Pilot Initiative program MIPR DWAM31168. The views and conclusions
contained in this document are those of the authors and should not be
interpreted as representing the official policies, either expressed or
implied, of the Army Research Laboratory or U.S. Government The U.S.
Government is authorized to reproduce and distribute reprints for
Government purposes notwithstanding any copyright notation herein.
NR 36
TC 1
Z9 1
U1 0
U2 7
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0031-9384
J9 PHYSIOL BEHAV
JI Physiol. Behav.
PD OCT 1
PY 2015
VL 149
BP 287
EP 293
DI 10.1016/j.physbeh.2015.05.026
PG 7
WC Psychology, Biological; Behavioral Sciences
SC Psychology; Behavioral Sciences
GA CO2ZR
UT WOS:000359026400039
PM 26025786
ER
PT J
AU Malati, P
Mehrotra, P
Minoofar, P
Mackie, DM
Sumner, JJ
Ganguli, R
AF Malati, P.
Mehrotra, P.
Minoofar, P.
Mackie, D. M.
Sumner, J. J.
Ganguli, R.
TI Diffusion-driven proton exchange membrane fuel cell for converting
fermenting biomass to electricity
SO BIORESOURCE TECHNOLOGY
LA English
DT Article
DE Biomass to electricity conversion; Biohybrid direct ethanol fuel cell;
Sugar fermentation; Waste to electrical energy; Microbial fuel cell
ID ENERGY; ETHANOL; GLUCOSE; STATE
AB A membrane-integrated proton exchange membrane fuel cell that enables in situ fermentation of sugar to ethanol, diffusion-driven separation of ethanol, and its catalytic oxidation in a single continuous process is reported. The fuel cell consists of a fermentation chamber coupled to a direct ethanol fuel cell. The anode and fermentation chambers are separated by a reverse osmosis (RO) membrane. Ethanol generated from fermented biomass in the fermentation chamber diffuses through the RO membrane into a glucose solution contained in the DEFC anode chamber. The glucose solution is osmotically neutral to the biomass solution in the fermentation chamber preventing the anode chamber from drying out. The fuel cell sustains > 1.3 mW cm(-2) at 47 degrees C with high discharge capacity. No separate purification or dilution is necessary, resulting in an efficient and portable system for direct conversion of fermenting biomass to electricity. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Malati, P.; Mehrotra, P.; Minoofar, P.; Ganguli, R.] Teledyne Sci Co, Thousand Oaks, CA 91360 USA.
[Mackie, D. M.; Sumner, J. J.] US Army Res Lab, SEDD, Adelphi, MD USA.
RP Ganguli, R (reprint author), Teledyne Sci Co, 1049 Camino Dos Rios, Thousand Oaks, CA 91360 USA.
EM rahul.ganguli@teledyne.com
FU U.S. Army's Institute of Collaborative Biotechnologies (ICB)
[W911NF-09-D-0001]
FX The authors acknowledge funding from the U.S. Army's Institute of
Collaborative Biotechnologies (ICB) under contract number
W911NF-09-D-0001.
NR 14
TC 1
Z9 1
U1 0
U2 25
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0960-8524
EI 1873-2976
J9 BIORESOURCE TECHNOL
JI Bioresour. Technol.
PD OCT
PY 2015
VL 194
BP 394
EP 398
DI 10.1016/j.biortech.2015.07.001
PG 5
WC Agricultural Engineering; Biotechnology & Applied Microbiology; Energy &
Fuels
SC Agriculture; Biotechnology & Applied Microbiology; Energy & Fuels
GA CN9UX
UT WOS:000358796600050
PM 26208756
ER
PT J
AU Hamilton, JB
Galbraith, KV
Best, NC
Worthy, VC
Moore, LTCAD
AF Hamilton, Jill B.
Galbraith, Kayoll V.
Best, Nakia C.
Worthy, Valarie C.
Moore, L. T. C. Angelo D.
TI African-American Cancer Survivors' Use of Religious Beliefs to
Positively Influence the Utilization of Cancer Care
SO JOURNAL OF RELIGION & HEALTH
LA English
DT Article
DE African-American; Cancer; Survivorship; Religion; Access to care
ID RANDOMIZED CONTROLLED-TRIAL; STRESSFUL LIFE EVENTS; BREAST-CANCER;
RACIAL DISPARITIES; GOD; SPIRITUALITY; SUPPORT; WOMEN
AB Among African-Americans, religion impacts health-seeking behaviors. This qualitative study used criterion purposeful sampling and thematic analysis in analysis of data from 31 African-American cancer patients to understand the influence of religion on the utilization of cancer care services. Our findings suggest that religious beliefs and practices positively influenced attitudes toward their illness and ability to endure treatment. God's ability to heal and cure, God's control over survival, God's will over their lives, and God's promise for health and prosperity were examples of survivor's religious beliefs. Religious practices such as prayer promoted a trusting relationship with healthcare providers and were a source of strength and encouragement.
C1 [Hamilton, Jill B.] Johns Hopkins Univ, Sch Nursing, Dept Community Publ Hlth, Baltimore, MD 21205 USA.
[Galbraith, Kayoll V.; Best, Nakia C.] Univ N Carolina, Sch Nursing, Chapel Hill, NC 27599 USA.
[Worthy, Valarie C.] Sisters Network Inc, Durham, NC 27707 USA.
[Moore, L. T. C. Angelo D.] US Army, Ctr Nursing Sci & Clin Inquiry, Womack Army Med Ctr, Ft Bragg, NC USA.
RP Hamilton, JB (reprint author), Johns Hopkins Univ, Sch Nursing, Dept Community Publ Hlth, 525 N Wolfe St, Baltimore, MD 21205 USA.
EM jhamil32@jhu.edu
FU Center for Spirituality Theology and Health at Duke University;
University of North Carolina Lineberger Comprehensive Cancer Center
FX The study in this report was supported with funds from the Center for
Spirituality Theology and Health at Duke University (J. Hamilton,
Principal Investigator) and the University of North Carolina Lineberger
Comprehensive Cancer Center (J. Hamilton, Principal Investigator).
NR 46
TC 1
Z9 1
U1 1
U2 9
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0022-4197
EI 1573-6571
J9 J RELIG HEALTH
JI J. Relig. Health
PD OCT
PY 2015
VL 54
IS 5
BP 1856
EP 1869
DI 10.1007/s10943-014-9948-6
PG 14
WC Public, Environmental & Occupational Health; Religion
SC Public, Environmental & Occupational Health; Religion
GA CN1FY
UT WOS:000358164800026
PM 25269756
ER
PT J
AU Smith, JR
Amaya, KR
Bredemeier, RT
Banta, S
Cropek, DM
AF Smith, Justin R.
Amaya, Kensey R.
Bredemeier, Rudi T.
Banta, Scott
Cropek, Donald M.
TI Selective biomolecular photocatalytic decomposition using
peptide-modified TiO2 nanoparticles
SO APPLIED CATALYSIS B-ENVIRONMENTAL
LA English
DT Article
DE Photocatalysis; TiO2; Surface modification; Affinity peptides; Protein
degradation
ID MODIFIED TITANIUM-DIOXIDE; VISIBLE-LIGHT IRRADIATION; SEMICONDUCTOR
PHOTOCATALYSIS; SURFACE MODIFICATION; PHOTOCHEMICAL REDUCTION; AFFINITY
PEPTIDE; THIN-FILMS; ATR-FTIR; DEGRADATION; ACID
AB Titanium dioxide (TiO2) is a photocatalyst widely used for the degradation of inorganic and organic contaminants in the environment; however, its lack of chemical specificity can be a particular limitation since every species in solution, including valued, innocuous, and deactivating compounds, will be degraded or deleterious to the process. Here, we describe a means to target the photocatalysis by surface modification of nanoparticulate TiO2 with a 13 amino acid streptavidin binding peptide (SBP) for the selective degradation of streptavidin, a 60 kDa tetrameric protein. Modification of the TiO2 surface with the affinity peptide was confirmed by fourier transform infrared spectroscopy (FTIR), UV/Vis absorbance, and secondary ion mass spectrometry (SIMS), while streptavidin binding and affinity to bound SBP were tested using fluorescently tagged antibodies against streptavidin. Results show that the SBP retains its affinity toward streptavidin after immobilization onto TiO2. Photodegradation studies using the visible region of simulated solar radiation (>= 360nm) showed rapid streptavidin degradation by SBP-TiO2 both in solution and while the photocatalyst was immobilized as a thin film on a glass substrate. In contrast, photocatalytic degradation of a non-target protein, lysozyme, was inhibited by the SBP monolayer and incompletely degraded, indicating that surface modification with biorecognition agents can control and modulate the photocatalytic process. Moreover, after extended illumination (3 h), the SBP-modified TiO2 surface retained its ability to bind streptavidin demonstrating that the SBP is stable at the TiO2 surface and that the SBP-TiO2 surface is reusable. These results indicate that the modification of TiO2 with covalently bound peptide recognition moieties offers the ability to selectively degrade target proteins of interest, leaving non-target components largely unaffected. Published by Elsevier B.V.
C1 [Smith, Justin R.; Amaya, Kensey R.; Bredemeier, Rudi T.; Cropek, Donald M.] US Army Engn Res & Dev Ctr, Construct Engn Res Lab CERL, Champaign, IL 61822 USA.
[Banta, Scott] Columbia Univ, Dept Chem Engn, New York, NY 10027 USA.
RP Cropek, DM (reprint author), POB 9005, Champaign, IL 61826 USA.
EM Donald.M.Cropek@usace.army.mil
FU Defense Threat Reduction Agency (DTRA) [BRCALL07-E-20035]
FX We thank Timothy Spila for his assistance with the ToF-SIMS. Research
was carried out in part in the Frederick Seitz Materials Research
Laboratory Central Facilities, University of Illinois at
Urbana-Champaign. This research was funded by the Defense Threat
Reduction Agency (DTRA), grant number BRCALL07-E-2-0035.
NR 62
TC 2
Z9 2
U1 5
U2 83
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0926-3373
EI 1873-3883
J9 APPL CATAL B-ENVIRON
JI Appl. Catal. B-Environ.
PD OCT
PY 2015
VL 176
BP 315
EP 324
DI 10.1016/j.apcatb.2015.03.060
PG 10
WC Chemistry, Physical; Engineering, Environmental; Engineering, Chemical
SC Chemistry; Engineering
GA CK9GS
UT WOS:000356549200032
ER
PT J
AU Bounds, CE
Kwilas, SA
Kuehne, AI
Brannan, JM
Bakken, RR
Dye, JM
Hooper, JW
Dupuy, LC
Ellefsen, B
Hannaman, D
Wu, H
Jiao, JA
Sullivan, EJ
Schmaljohn, CS
AF Bounds, Callie E.
Kwilas, Steven A.
Kuehne, Ana I.
Brannan, Jennifer M.
Bakken, Russell R.
Dye, John M.
Hooper, Jay W.
Dupuy, Lesley C.
Ellefsen, Barry
Hannaman, Drew
Wu, Hua
Jiao, Jin-an
Sullivan, Eddie J.
Schmaljohn, Connie S.
TI Human Polyclonal Antibodies Produced through DNA Vaccination of
Transchromosomal Cattle Provide Mice with Post-Exposure Protection
against Lethal Zaire and Sudan Ebolaviruses
SO PLOS ONE
LA English
DT Article
ID EBOLA-VIRUS-INFECTION; DEFECTIVE INTERFERING VIRUS; NONHUMAN-PRIMATES;
HEMORRHAGIC-FEVER; IMMUNE-RESPONSES; ELECTROPORATION; PROPHYLAXIS;
CHALLENGE; PARTICLES; INFLUENZA
AB DNA vaccination of transchromosomal bovines (TcBs) with DNA vaccines expressing the codon-optimized (co) glycoprotein (GP) genes of Ebola virus (EBOV) and Sudan virus (SUDV) produce fully human polyclonal antibodies (pAbs) that recognize both viruses and demonstrate robust neutralizing activity. Each TcB was vaccinated by intramuscular electroporation (IM-EP) a total of four times and at each administration received 10 mg of the EBOV-GP(co) DNA vaccine and 10 mg of the SUDV-GP(co) DNA vaccine at two sites on the left and right sides, respectively. After two vaccinations, robust antibody responses (titers > 1000) were detected by ELISA against whole irradiated EBOV or SUDV and recombinant EBOV-GP or SUDV-GP (rGP) antigens, with higher titers observed for the rGP antigens. Strong, virus neutralizing antibody responses (titers > 1000) were detected after three vaccinations when measured by vesicular stomatitis virus-based pseudovirion neutralization assay (PsVNA). Maximal neutralizing antibody responses were identified by traditional plaque reduction neutralization tests (PRNT) after four vaccinations. Neutralizing activity of human immunoglobulins (IgG) purified from TcB plasma collected after three vaccinations and injected intraperitoneally (IP) into mice at a 100 mg/kg dose was detected in the serum by PsVNA up to 14 days after administration. Passive transfer by IP injection of the purified IgG (100 mg/kg) to groups of BALB/c mice one day after IP challenge with mouse adapted (ma) EBOV resulted in 80% protection while all mice treated with non-specific pAbs succumbed. Similarly, interferon receptor 1 knockout (IFNAR(-/-)) mice receiving the purified IgG (100 mg/kg) by IP injection one day after IP challenge with wild type SUDV resulted in 89% survival. These results are the first to demonstrate that filovirus GP DNA vaccines administered to TcBs by IM-EP can elicit neutralizing antibodies that provide post-exposure protection. Additionally, these data describe production of fully human IgG in a large animal system, a system which is capable of producing large quantities of a clinical grade therapeutic product.
C1 [Bounds, Callie E.; Kwilas, Steven A.; Kuehne, Ana I.; Brannan, Jennifer M.; Bakken, Russell R.; Dye, John M.; Hooper, Jay W.; Dupuy, Lesley C.; Schmaljohn, Connie S.] US Army Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
[Wu, Hua; Jiao, Jin-an; Sullivan, Eddie J.] SAB Biotherapeut, Sioux Falls, SD USA.
[Ellefsen, Barry; Hannaman, Drew] Ichor Med Syst Inc, San Diego, CA USA.
RP Schmaljohn, CS (reprint author), US Army Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA.
EM connie.s.schmaljohn.civ@mail.mil
OI Hooper, Jay/0000-0002-4475-0415
FU Defense Threat Reduction Agency (DTRA) [HDTRA1-14-1-0054]
FX This research was supported by contract HDTRA1-14-1-0054 to SAB
Biotherapeutics, Inc., from the Defense Threat Reduction Agency (DTRA).
This research was performed under Cooperative Research and Development
Agreement (CRADA) W81XWH-14-0315 between USAMRIID and SAB
Biotherapeutics, Inc. The funders had no had no role in study design,
data collection and analysis, decision to publish, or preparation of the
manuscript.
NR 44
TC 5
Z9 5
U1 0
U2 1
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 30
PY 2015
VL 10
IS 9
AR e0137786
DI 10.1371/journal.pone.0137786
PG 18
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CS6GF
UT WOS:000362175700017
PM 26422247
ER
PT J
AU Yu, KM
Ting, M
Novikov, SV
Collin, C
Sarney, WL
Svensson, SP
Luce, AV
Denlinger, JD
Walukiewicz, W
Foxon, CT
AF Yu, K. M.
Ting, Min
Novikov, S. V.
Collin, Clement
Sarney, W. L.
Svensson, S. P.
Luce, A. V.
Denlinger, J. D.
Walukiewicz, W.
Foxon, C. T.
TI Effects of native defects on properties of low temperature grown,
non-stoichiomtric gallium nitride
SO JOURNAL OF PHYSICS D-APPLIED PHYSICS
LA English
DT Article
DE gallium nitride; low temperature MBE; optical properties;
non-stoichiometry; native defects
ID MOLECULAR-BEAM EPITAXY; STRUCTURAL-PROPERTIES; GAAS; EXCESS; GAN
AB The properties of GaN thin films grown by molecular beam epitaxy at temperatures from 80 to 500 degrees C under a wide range of Ga:N flux ratios are studied. We found that at growth temperatures as low as similar to 80 degrees C, GaN films still have a polycrystalline, columnar morphology with c-axis preferred orientation. Soft x-ray absorption and emission and optical absorption measurements on Ga-rich samples suggest the presence of a partially occupied GaN antisite defect band located at similar to 1.2 eV below the conduction band minimum. P-type conductivity observed in this LTMBE Ga-rich GaN is consistent with transport within this partially occupied defect band.
C1 [Yu, K. M.] City Univ Hong Kong, Dept Phys & Mat Sci, Kowloon, Hong Kong, Peoples R China.
[Yu, K. M.; Ting, Min; Luce, A. V.; Walukiewicz, W.] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Div Mat Sci, Berkeley, CA 94720 USA.
[Ting, Min] Univ Calif Berkeley, Dept Mech Engn, Berkeley, CA 94720 USA.
[Novikov, S. V.; Foxon, C. T.] Univ Nottingham, Sch Phys & Astron, Nottingham NG7 2RD, England.
[Collin, Clement] Grenoble Inst Technol, F-38000 Grenoble, France.
[Sarney, W. L.; Svensson, S. P.] US Army Res Lab, Adelphi, MD 20783 USA.
[Luce, A. V.] Univ Calif Berkeley, Dept Mat Sci & Engn, Berkeley, CA 94720 USA.
[Denlinger, J. D.] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Adv Light Source, Berkeley, CA 94720 USA.
RP Yu, KM (reprint author), City Univ Hong Kong, Dept Phys & Mat Sci, Kowloon, Hong Kong, Peoples R China.
EM kinmanyu@cityu.edu.hk
OI Yu, Kin Man/0000-0003-1350-9642
FU EPSRC [EP/I004203/1]; US Army [W911NF-12-2-0003]; ARO; ITC-Atlantic; US
Department of Energy, Office of Science, Basic Energy Sciences,
Materials Sciences and Engineering Division [DE-AC02-05CH11231]
FX The MBE growth at the University of Nottingham was undertaken with
support from the EPSRC (EP/I004203/1) and by the US Army under
cooperative agreement No. W911NF-12-2-0003 as well as by ARO and
ITC-Atlantic. RBS and electrical and optical measurements performed at
LBNL were supported by the US Department of Energy, Office of Science,
Basic Energy Sciences, Materials Sciences and Engineering Division under
Contract No. DE-AC02-05CH11231.
NR 19
TC 4
Z9 4
U1 1
U2 14
PU IOP PUBLISHING LTD
PI BRISTOL
PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
SN 0022-3727
EI 1361-6463
J9 J PHYS D APPL PHYS
JI J. Phys. D-Appl. Phys.
PD SEP 30
PY 2015
VL 48
IS 38
AR 385101
DI 10.1088/0022-3727/48/38/385101
PG 6
WC Physics, Applied
SC Physics
GA CS3HY
UT WOS:000361964400007
ER
PT J
AU Gao, T
Noked, M
Pearse, AJ
Gillette, E
Fan, XL
Zhu, YJ
Luo, C
Suo, LM
Schroeder, MA
Xu, K
Lee, SB
Rubloff, GW
Wang, CS
AF Gao, Tao
Noked, Malachi
Pearse, Alex J.
Gillette, Eleanor
Fan, Xiulin
Zhu, Yujie
Luo, Chao
Suo, Liumin
Schroeder, Marshall A.
Xu, Kang
Lee, Sang Bok
Rubloff, Gary W.
Wang, Chunsheng
TI Enhancing the Reversibility of Mg/S Battery Chemistry through Li+
Mediation
SO JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
LA English
DT Article
ID RECHARGEABLE MAGNESIUM BATTERIES; LITHIUM-SULFUR BATTERIES;
ELECTROLYTE-SOLUTIONS; CATHODE; PERFORMANCE; INTERCALATION; STORAGE;
DEPOSITION; CHALLENGE; MG2+
AB Mg metal is a promising anode material for next generation rechargeable battery due to its dendrite-free deposition and high capacity. However, the best cathode for rechargeable Mg battery was based on high molecular weight MgxMo3S4, thus rendering full cell energetically uncompetitive. To increase energy density, high capacity cathode material like sulfur is proposed. However, to date, only limited work has been reported on Mg/S system, all plagued by poor reversibility attributed to the formation of electrochemically inactive MgSx species. Here, we report a new strategy, based on the effect of Li+ in activating activating MgSx species, to conjugate a dendrite-free Mg anode with a reversible polysulfide cathode and present a truly reversible Mg/S battery with capacity up to 1000 mAh/g(s) for more than 30 cycles. Mechanistic insights supported by spectroscopic and microscopic characterization strongly suggest that the reversibility arises from chemical reactivation of MgSx by Li+.
C1 [Gao, Tao; Fan, Xiulin; Zhu, Yujie; Luo, Chao; Suo, Liumin; Wang, Chunsheng] Univ Maryland, Dept Chem & Biomol Engn, College Pk, MD 20740 USA.
[Noked, Malachi; Pearse, Alex J.; Schroeder, Marshall A.; Rubloff, Gary W.] Univ Maryland, Dept Mat Sci & Engn, College Pk, MD 20740 USA.
[Noked, Malachi; Gillette, Eleanor; Lee, Sang Bok] Univ Maryland, Dept Chem & Biochem, College Pk, MD 20740 USA.
[Xu, Kang] US Army, Electrochem Branch, Power & Energy Div, Sensor & Elect Devices Directorate,Res Lab, Adelphi, MD 20783 USA.
RP Noked, M (reprint author), Univ Maryland, Dept Mat Sci & Engn, College Pk, MD 20740 USA.
EM mnoked@gmail.com; slee@umd.edu; rubloff@umd.edu; cwang@umd.edu
RI Wang, Chunsheng/H-5767-2011; Lee, Sang Bok/B-4421-2009; Pearse,
Alexander/B-2792-2017;
OI Wang, Chunsheng/0000-0002-8626-6381; Noked, Malachi/0000-0001-8995-0632
FU Nanostructures for Electrical Energy Storage (NEES), an Energy Frontier
Research Center - U.S. Department of Energy, Office of Science, Basic
Energy Sciences [DESC0001160]; Maryland NanoCenter; AIM Lab
FX This work was supported as part of the Nanostructures for Electrical
Energy Storage (NEES), an Energy Frontier Research Center funded by the
U.S. Department of Energy, Office of Science, Basic Energy Sciences
under Award Number DESC0001160. We acknowledge the support of the
Maryland NanoCenter and its AIM Lab. We acknowledge the Environmental
Engineering Lab for use of their ICP-OES. We acknowledge Professor Doron
Aurbach, Dr. Kevin Leung and Mr. Fudong Han for their valuable comments.
NR 39
TC 15
Z9 15
U1 25
U2 162
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0002-7863
J9 J AM CHEM SOC
JI J. Am. Chem. Soc.
PD SEP 30
PY 2015
VL 137
IS 38
BP 12388
EP 12393
DI 10.1021/jacs.5b07820
PG 6
WC Chemistry, Multidisciplinary
SC Chemistry
GA CS7DC
UT WOS:000362243300033
PM 26360783
ER
PT J
AU Honnold, SP
Mossel, EC
Bakken, RR
Lind, CM
Cohen, JW
Eccleston, LT
Spurgers, KB
Erwin-Cohen, R
Glass, PJ
Maheshwari, RK
AF Honnold, Shelley P.
Mossel, Eric C.
Bakken, Russell R.
Lind, Cathleen M.
Cohen, Jeffrey W.
Eccleston, Lori T.
Spurgers, Kevin B.
Erwin-Cohen, Rebecca
Glass, Pamela J.
Maheshwari, Radha K.
TI Eastern equine encephalitis virus in mice II: pathogenesis is dependent
on route of exposure
SO VIROLOGY JOURNAL
LA English
DT Article
DE Alphavirus; Eastern equine encephalitis virus; Neuroinvasion; Mice
ID CENTRAL-NERVOUS-SYSTEM; CELL-DEATH; NECROSIS; APOPTOSIS; STRAINS;
NEUROVIRULENCE; INFECTION; AUTOPHAGY; TROPISM
AB Background: Eastern equine encephalitis virus (EEEV) is an alphavirus with a case fatality rate estimated to be as high as 75 % in humans and 90 % in horses. Surviving patients often have long-lasting and severe neurological sequelae. At present, there is no licensed vaccine or therapeutic for EEEV infection. This study completes the clinical and pathological analysis of mice infected with a North American strain of EEEV by three different routes: aerosol, intranasal, and subcutaneous. Such an understanding is imperative for use of the mouse model in vaccine and antiviral drug development.
Methods: Twelve-week-old female BALB/c mice were infected with EEEV strain FL93-939 by the intranasal, aerosol, or subcutaneous route. Mice were euthanized 6 hpi through 8 dpi and tissues were harvested for histopathological and immunohistochemical analysis.
Results: Viral antigen was detected in the olfactory bulb as early as 1-2 dpi in aerosol and intranasal infected mice. However, histologic lesions in the brain were evident about 24 hours earlier (3 dpi vs 4 dpi), and were more pronounced following aerosol infection relative to intranasal infection. Following subcutaneous infection, viral antigen was also detected in the olfactory bulb, though not as routinely or as early. Significant histologic lesions were not observed until 6 dpi.
Conclusion: These pathologic studies suggest EEEV enters the brain through the olfactory system when mice are exposed via the intranasal and aerosol routes. In contrast, the histopathologic lesions were delayed in the subcutaneous group and it appears the virus may utilize both the vascular and olfactory routes to enter the brain when mice are exposed to EEEV subcutaneously.
C1 [Honnold, Shelley P.; Mossel, Eric C.; Bakken, Russell R.; Lind, Cathleen M.; Cohen, Jeffrey W.; Eccleston, Lori T.; Spurgers, Kevin B.; Erwin-Cohen, Rebecca; Glass, Pamela J.] US Army Med Res Inst Infect Dis, Div Virol, Frederick, MD 21702 USA.
[Honnold, Shelley P.; Maheshwari, Radha K.] Uniformed Serv Univ Hlth Sci, Dept Pathol, Bethesda, MD 20814 USA.
RP Honnold, SP (reprint author), US Army Med Res Inst Infect Dis, Div Virol, Frederick, MD 21702 USA.
EM shelley.p.honnold.mil@mail.mil
OI Honnold, Shelley/0000-0002-3461-0240
FU Defense Threat Reduction Agency (DTRA) [H.H.0003_07_RD_B, CB3691]
FX We thank Neil Davis and Gale Kreitz of the Pathology Division at
USAMRIID for providing excellent histopathology support, and a special
thanks to Chris Mech for providing outstanding immunohistochemistry
support. Additionally, we thank William Discher of the Visual
Information Office at USAMRIID for providing imaging support and figure
formatting. Opinions, interpretations, conclusions, and recommendations
are those of the authors and are not necessarily endorsed by the U.S.
Army. Research was conducted under an IACUC approved protocol in
compliance with the Animal Welfare Act, PHS Policy, and other Federal
statutes and regulations relating to animals and experiments involving
animals. The facility where this research was conducted is accredited by
the Association for Assessment and Accreditation of Laboratory Animal
Care, International and adheres to principles stated in the Guide for
the Care and Use of Laboratory Animals, National Research Council, 2011.
This work was supported in part by the Defense Threat Reduction Agency
(DTRA); project numbers H.H.0003_07_RD_B and CCAR# CB3691.
NR 32
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U1 2
U2 10
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1743-422X
J9 VIROL J
JI Virol. J.
PD SEP 30
PY 2015
VL 12
AR 154
DI 10.1186/s12985-015-0385-2
PG 23
WC Virology
SC Virology
GA CS4RY
UT WOS:000362064800001
PM 26423229
ER
PT J
AU Honnold, SP
Mossel, EC
Bakken, RR
Fisher, D
Lind, CM
Cohen, JW
Eccleston, LT
Spurgers, KB
Erwin-Cohen, R
Bradfute, SB
Maheshwari, RK
Glass, PJ
AF Honnold, Shelley P.
Mossel, Eric C.
Bakken, Russell R.
Fisher, Diana
Lind, Cathleen M.
Cohen, Jeffrey W.
Eccleston, Lori T.
Spurgers, Kevin B.
Erwin-Cohen, Rebecca
Bradfute, Steven B.
Maheshwari, Radha K.
Glass, Pamela J.
TI Eastern equine encephalitis virus in mice I: clinical course and outcome
are dependent on route of exposure
SO VIROLOGY JOURNAL
LA English
DT Article
DE Alphavirus; Eastern equine encephalitis virus; Neuroinvasion; Mice
ID PATHOGENESIS; INFECTION; STRAINS
AB Background: Eastern equine encephalitis virus (EEEV), an arbovirus, is an important human and veterinary pathogen belonging to one of seven antigenic complexes in the genus Alphavirus, family Togaviridae. EEEV is considered the most deadly of the mosquito-borne alphaviruses due to the high case fatality rate associated with clinical infections, reaching up to 75 % in humans and 90 % in horses. In patients that survive acute infection, neurologic sequelae are often devastating. Although natural infections are acquired by mosquito bite, EEEV is also highly infectious by aerosol. This fact, along with the relative ease of production and stability of this virus, has led it to being identified as a potential agent of bioterrorism.
Methods: To characterize the clinical course and outcome of EEEV strain FL93-939 infection, we compared clinical parameters, cytokine expression, viremia, and viral titers in numerous tissues of mice exposed by various routes. Twelve-week-old female BALB/c mice were infected by the intranasal, aerosol, or subcutaneous route. Mice were monitored for clinical signs of disease and euthanized at specified time points (6 hpi through 8 dpi). Blood and tissues were harvested for cytokine analysis and/or viral titer determination.
Results: Although all groups of animals exhibited similar clinical signs after inoculation, the onset and severity differed. The majority of those animals exposed by the aerosol route developed severe clinical signs by 4 dpi. Significant differences were also observed in the viral titers of target tissues, with virus being detected in the brain at 6 hpi in the aerosol study.
Conclusion: The clinical course and outcome of EEEV infection in mice is dependent on route of exposure. Aerosol exposure to EEEV results in acute onset of clinical signs, rapid neuroinvasion, and 100 % mortality.
C1 [Honnold, Shelley P.; Mossel, Eric C.; Bakken, Russell R.; Fisher, Diana; Lind, Cathleen M.; Cohen, Jeffrey W.; Eccleston, Lori T.; Spurgers, Kevin B.; Erwin-Cohen, Rebecca; Glass, Pamela J.] US Army Med Res Inst Infect Dis, Virol Div, Frederick, MD 21702 USA.
[Honnold, Shelley P.; Bradfute, Steven B.] US Army Med Res Inst Infect Dis, Integrated Toxicol Div, Frederick, MD 21702 USA.
[Maheshwari, Radha K.] Uniformed Serv Univ Hlth Sci, Dept Pathol, Bethesda, MD 20814 USA.
RP Honnold, SP (reprint author), Univ New Mexico, Dept Internal Med, Ctr Global Hlth, Albuquerque, NM 87131 USA.
EM shelley.p.honnold.mil@mail.mil
OI Honnold, Shelley/0000-0002-3461-0240
FU Defense Threat Reduction Agency (DTRA) [H.H.0003_07_RD_B, CB3691]
FX Opinions, interpretations, conclusions, and recommendations are those of
the authors and are not necessarily endorsed by the U.S. Army. Research
was conducted under an IACUC approved protocol in compliance with the
Animal Welfare Act, PHS Policy, and other Federal statutes and
regulations relating to animals and experiments involving animals. The
facility where this research was conducted is accredited by the
Association for Assessment and Accreditation of Laboratory Animal Care,
International and adheres to principles stated in the Guide for the Care
and Use of Laboratory Animals, National Research Council, 2011. This
work was supported in part by the Defense Threat Reduction Agency
(DTRA); project numbers H.H.0003_07_RD_B and CCAR# CB3691.
NR 17
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U1 2
U2 7
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1743-422X
J9 VIROL J
JI Virol. J.
PD SEP 30
PY 2015
VL 12
AR 152
DI 10.1186/s12985-015-0386-1
PG 14
WC Virology
SC Virology
GA CS2BS
UT WOS:000361873400001
PM 26420265
ER
PT J
AU Huang, SY
O'Donovan, KJ
Turner, EE
Zhong, J
Ginty, DD
AF Huang, Siyi
O'Donovan, Kevin J.
Turner, Eric E.
Zhong, Jian
Ginty, David D.
TI Extrinsic and intrinsic signals converge on the Runx1/CBF beta
transcription factor for nonpeptidergic nociceptor maturation
SO ELIFE
LA English
DT Article
ID DORSAL-ROOT GANGLIA; NERVE GROWTH-FACTOR; PRIMARY SENSORY NEURONS;
SYMPATHETIC NEURONS; DRG NEURONS; IN-VIVO; OSTEOBLAST DIFFERENTIATION;
AXON GROWTH; MICE; EXPRESSION
AB The generation of diverse neuronal subtypes involves specification of neural progenitors and, subsequently, postmitotic neuronal differentiation, a relatively poorly understood process. Here, we describe a mechanism whereby the neurotrophic factor NGF and the transcription factor Runx1 coordinate postmitotic differentiation of nonpeptidergic nociceptors, a major nociceptor subtype. We show that the integrity of a Runx1/CBF beta holocomplex is crucial for NGF-dependent nonpeptidergic nociceptor maturation. NGF signals through the ERK/MAPK pathway to promote expression of Cbfb but not Runx1 prior to maturation of nonpeptidergic nociceptors. In contrast, transcriptional initiation of Runx1 in nonpeptidergic nociceptor precursors is dependent on the homeodomain transcription factor Islet1, which is largely dispensable for Cbfb expression. Thus, an NGF/TrkA-MAPK-CBF beta pathway converges with Islet1-Runx1 signaling to promote Runx1/CBF beta holocomplex formation and nonpeptidergic nociceptor maturation. Convergence of extrinsic and intrinsic signals to control heterodimeric transcription factor complex formation provides a robust mechanism for postmitotic neuronal subtype specification.
C1 [Huang, Siyi; Ginty, David D.] Harvard Univ, Sch Med, Howard Hughes Med Inst, Dept Neurobiol, Boston, MA 02115 USA.
[Huang, Siyi; Ginty, David D.] Johns Hopkins Sch Med, Howard Hughes Med Inst, Dept Neurosci, Baltimore, MD USA.
[O'Donovan, Kevin J.; Zhong, Jian] Cornell Univ, Weill Med Coll, Burke Med Res Inst, White Plains, NY USA.
[Turner, Eric E.] Seattle Childrens Hosp, Seattle Childrens Res Inst, Seattle, WA USA.
[O'Donovan, Kevin J.] US Mil Acad, Dept Chem & Life Sci, West Point, PA USA.
RP Ginty, DD (reprint author), Harvard Univ, Sch Med, Howard Hughes Med Inst, Dept Neurobiol, Boston, MA 02115 USA.; Ginty, DD (reprint author), Johns Hopkins Sch Med, Howard Hughes Med Inst, Dept Neurosci, Baltimore, MD USA.
EM david_ginty@hms.harvard.edu
FU National Institutes of Health [NS34814, NS064933]; Whitehall Foundation
[2010-08-61]; National Eye Institute [1R01EY022409]
FX Funder Grant reference number Author; National Institutes of Health
NS34814 David D Ginty; Whitehall Foundation 2010-08-61 Jian Zhong;
National Eye Institute 1R01EY022409 Jian Zhong; National Institutes of
Health NS064933 Eric E Turner; The funders had no role in study design,
data collection and interpretation, or the decision to submit the work
for publication.
NR 56
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U1 1
U2 1
PU ELIFE SCIENCES PUBLICATIONS LTD
PI CAMBRIDGE
PA SHERATON HOUSE, CASTLE PARK, CAMBRIDGE, CB3 0AX, ENGLAND
SN 2050-084X
J9 ELIFE
JI eLife
PD SEP 29
PY 2015
VL 4
AR e10874
DI 10.7554/eLife.10874
PG 24
WC Biology
SC Life Sciences & Biomedicine - Other Topics
GA DJ0GI
UT WOS:000373879500001
PM 26418744
ER
PT J
AU Johnston, SC
Lin, KL
Twenhafel, NA
Raymond, JLW
Shamblin, JD
Wollen, SE
Wlazlowski, CB
Wilkinson, ER
Botto, MA
Goff, AJ
AF Johnston, Sara C.
Lin, Kenny L.
Twenhafel, Nancy A.
Raymond, Jo Lynne W.
Shamblin, Joshua D.
Wollen, Suzanne E.
Wlazlowski, Carly B.
Wilkinson, Eric R.
Botto, Miriam A.
Goff, Arthur J.
TI Dose Response of MARV/Angola Infection in Cynomolgus Macaques following
IM or Aerosol Exposure
SO PLOS ONE
LA English
DT Article
ID MARBURG-VIRUS-DISEASE; HEMORRHAGIC-FEVER; ANGOLA INFECTION; RHESUS
MACAQUES; PATHOGENESIS; CHALLENGE; OUTBREAK; CONGO
AB Marburg virus infection in humans causes a hemorrhagic disease with a high case fatality rate. Countermeasure development requires the use of well-characterized animal models that mimic human disease. To further characterize the cynomolgus macaque model of MARV/Angola, two independent dose response studies were performed using the intramuscular or aerosol routes of exposure. All animals succumbed at the lowest target dose; therefore, a dose effect could not be determined. For intramuscular-exposed animals, 100 PFU was the first target dose that was not significantly different than higher target doses in terms of time to disposition, clinical pathology, and histopathology. Although a significant difference was not observed between aerosol-exposed animals in the 10 PFU and 100 PFU target dose groups, 100 PFU was determined to be the lowest target dose that could be consistently obtained and accurately titrated in aerosol studies.
C1 [Johnston, Sara C.; Shamblin, Joshua D.; Wollen, Suzanne E.; Wlazlowski, Carly B.; Wilkinson, Eric R.; Botto, Miriam A.; Goff, Arthur J.] US Army, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA.
[Lin, Kenny L.] US Army, Med Res Inst Infect Dis, Nonclin Dev Div, Ft Detrick, MD 21702 USA.
[Twenhafel, Nancy A.; Raymond, Jo Lynne W.] US Army, Med Res Inst Infect Dis, Div Pathol, Ft Detrick, MD 21702 USA.
RP Johnston, SC (reprint author), US Army, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA.
EM sara.c.johnston2.ctr@mail.mil
FU Translational Medical Technologies; Joint Science and Technology Office
for Chemical and Biological Defense
FX This work was supported by Translational Medical Technologies and the
Joint Science and Technology Office for Chemical and Biological Defense.
The funders had no role in study design, data collection and analysis,
decision to publish, or preparation of the manuscript.
NR 18
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U1 2
U2 2
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 28
PY 2015
VL 10
IS 9
AR e0138843
DI 10.1371/journal.pone.0138843
PG 13
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CS6EO
UT WOS:000362170700024
PM 26413900
ER
PT J
AU Horowitz, JM
Jacobs, K
AF Horowitz, Jordan M.
Jacobs, Kurt
TI Energy Cost of Controlling Mesoscopic Quantum Systems
SO PHYSICAL REVIEW LETTERS
LA English
DT Article
ID STATE; OSCILLATOR; CIRCUIT
AB We determine the minimum energy required to control the evolution of any mesoscopic quantum system in the presence of arbitrary Markovian noise processes. This result provides the mesoscopic equivalent of the fundamental cost of refrigeration, sets the minimum power consumption of mesoscopic devices that operate out of equilibrium, and allows one to calculate the efficiency of any control protocol, whether it be open-loop or feedback control. As examples, we calculate the energy cost of maintaining a qubit in the ground state and the efficiency of resolved-sideband cooling of nano-mechanical resonators, and discuss the energy cost of quantum information processing.
C1 [Horowitz, Jordan M.; Jacobs, Kurt] Univ Massachusetts, Dept Phys, Boston, MA 02125 USA.
[Jacobs, Kurt] US Army Res Lab, Computat & Informat Sci Directorate, Adelphi, MD 20783 USA.
[Jacobs, Kurt] Louisiana State Univ, Hearne Inst Theoret Phys, Baton Rouge, LA 70803 USA.
RP Horowitz, JM (reprint author), Univ Massachusetts, Dept Phys, Harbor Campus, Boston, MA 02125 USA.
RI Horowitz, Jordan/C-6754-2009
OI Horowitz, Jordan/0000-0002-9139-0811
FU ARO MURI [W911NF-11-1-0268]; NSF [PHY-1212413]
FX J. H. was partially supported by the ARO MURI Grant No.
W911NF-11-1-0268, and K. J. by the NSF Project No. PHY-1212413.
NR 33
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Z9 3
U1 2
U2 14
PU AMER PHYSICAL SOC
PI COLLEGE PK
PA ONE PHYSICS ELLIPSE, COLLEGE PK, MD 20740-3844 USA
SN 0031-9007
EI 1079-7114
J9 PHYS REV LETT
JI Phys. Rev. Lett.
PD SEP 25
PY 2015
VL 115
IS 13
AR 130501
DI 10.1103/PhysRevLett.115.130501
PG 5
WC Physics, Multidisciplinary
SC Physics
GA CS1GU
UT WOS:000361812200001
PM 26451540
ER
PT J
AU DeGregorio, BA
Westervelt, JD
Weatherhead, PJ
Sperry, JH
AF DeGregorio, Brett A.
Westervelt, James D.
Weatherhead, Patrick J.
Sperry, Jinelle H.
TI Indirect effect of climate change: Shifts in ratsnake behavior alter
intensity and timing of avian nest predation
SO ECOLOGICAL MODELLING
LA English
DT Article
DE Activity patterns; Climate change; Forest edge; Ratsnakes; Netlogo;
Predator-prey interactions
ID BLACK RAT SNAKES; ELAPHE-OBSOLETA-OBSOLETA; HABITAT USE; BIRDS;
THERMOREGULATION; SUCCESS; POPULATION; MOVEMENTS; SELECTION; PATTERNS
AB Understanding how climate change will affect the abundance, distribution, and behavior of wildlife has garnered substantial attention, but predicting how climate change may alter interspecific relationships is more challenging and has received less attention. Here, we use agent-based modeling to explore how climate warming may alter activity patterns and habitat use of ratsnakes and how this will change their interactions with nesting birds. Overall nest predation by ratsnakes increased with warming environmental temperatures, with a 7% increase in daily nest predation as temperatures warmed by 2 degrees C. Modest increases in ambient temperature (0.5 degrees C) caused nocturnal predation by ratsnakes to increase by 15%, particularly in the early spring (200% increase in nocturnal nest predation in March) when nocturnal snake activity is currently limited. Increased nocturnal nest predation can have important demographic consequences beyond nest failure when adult birds on the nest are vulnerable to snakes. Increased temperatures also caused nest predation to increase substantially in forest and forest edge habitats. In a warming world ratsnakes are predicted to use forested habitats more because the thermal heterogeneity of forests buffers snakes against potentially lethal environmental temperatures. If ratsnakes become more concentrated in small forest patches and edges, nest survival in these patches may fall below a sustainable level. Conversely, as temperatures increase, ratsnakes will be less likely to prey on nests in open habitats such as shrublands, which may provide refuges for some nesting birds. Species conservation in a warming world requires understanding how the behavior of both the focal species and its predators are affected. Published by Elsevier B.V.
C1 [DeGregorio, Brett A.; Weatherhead, Patrick J.] Univ Illinois, Dept Nat Resources & Environm Sci, Urbana, IL 61801 USA.
[DeGregorio, Brett A.; Westervelt, James D.; Sperry, Jinelle H.] Engineer Res & Dev Ctr, Champaign, IL 61826 USA.
RP DeGregorio, BA (reprint author), Univ Illinois, Dept Nat Resources & Environm Sci, Urbana, IL 61801 USA.
EM badegregorio@gmail.com
FU Construction Engineering Research Laboratory of the Engineer Research
Development Center; South Carolina Department of Natural Resources
permits [G-11-03, 23-2012A]; University of Illinois [10127, 11054];
University of Georgia [AUP 2011 04-007-Y2-AO]
FX Funding was provided by the Construction Engineering Research Laboratory
of the Engineer Research Development Center. We thank Tim Hayden for
assistance arranging funding. We thank Eric Nordberg, Mary Mack Grey,
Ashley Smith, Phil Vogrinc, Patrick Barnhart, Emily Williams, Mae
Cowgill, Patrick Roberts, Sara Wendt, Andrew Cronin, and Clay Noss for
assistance locating and monitoring bird nests and radiotracking rat
snakes. We thank Dr. Mathew Parker and Kelly Scott at the Savannah River
National Laboratory for providing meteorological data. The Savannah
River Ecology Laboratory and Tracey Tuberville graciously hosted our
research on the Savannah River Site. We thank Dr. Jason Norman and the
staff of the Hammond Hills Animal Hospital for radio-transmitter
implantation surgeries. All field work was conducted under South
Carolina Department of Natural Resources permits G-11-03 and 23-2012A.
All animal use procedures conformed to approved protocols through the
University of Illinois (# 10127 and 11054) and the University of Georgia
(AUP 2011 04-007-Y2-AO). We thank two anonymous reviewers who provided
thorough and helpful comments.
NR 59
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Z9 0
U1 6
U2 66
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0304-3800
EI 1872-7026
J9 ECOL MODEL
JI Ecol. Model.
PD SEP 24
PY 2015
VL 312
BP 239
EP 246
DI 10.1016/j.ecolmodel.2015.05.031
PG 8
WC Ecology
SC Environmental Sciences & Ecology
GA CN5KW
UT WOS:000358469200022
ER
PT J
AU Xiang, HF
Mei, DH
Yan, PF
Bhattacharya, P
Burton, SD
Cresce, AV
Cao, RG
Engelhard, MH
Bowden, ME
Zhu, ZH
Polzin, BJ
Wang, CM
Xu, K
Zhang, JG
Xu, W
AF Xiang, Hongfa
Mei, Donghai
Yan, Pengfei
Bhattacharya, Priyanka
Burton, Sarah D.
Cresce, Arthur von Wald
Cao, Ruiguo
Engelhard, Mark H.
Bowden, Mark E.
Zhu, Zihua
Polzin, Bryant J.
Wang, Chong-Min
Xu, Kang
Zhang, Ji-Guang
Xu, Wu
TI The Role of Cesium Cation in Controlling Interphasial Chemistry on
Graphite Anode in Propylene Carbonate-Rich Electrolytes
SO ACS APPLIED MATERIALS & INTERFACES
LA English
DT Article
DE graphite exfoliation; propylene carbonate; solid electrolyte interphase;
cesium cation; electrolyte
ID ELECTROCHEMICAL LITHIUM INTERCALATION; SOLVATION SHEATH STRUCTURE;
GRAPHITE/ELECTROLYTE INTERFACE; NONAQUEOUS ELECTROLYTES; ETHYLENE
CARBONATE; LI+ SOLVATION; CALCIUM-IONS; BATTERIES
AB Despite the potential advantages it brings, such as wider liquid range and lower cost, propylene carbonate (PC) is seldom used in lithium-ion batteries because of its sustained cointercalation into the graphene structure and the eventual graphite exfoliation. Here, we report that cesium cation (Cs+) directs the formation of solid electrolyte interphase on graphite anode in PC-rich electrolytes through its preferential solvation by ethylene carbonate (EC) and the subsequent higher reduction potential of the complex cation. Effective suppression of PC-decomposition and graphite-exfoliation is achieved by adjusting the EC/PC ratio in electrolytes to allow a reductive decomposition of Cs+-(EC)(m) (1 <= m <= 2) complex preceding that of Li+-(PC)(n) (3 <= n <= 5). Such Cs+-directed interphase is stable, ultrathin, and compact, leading to significant improvement in battery performances. In a broader context, the accurate tailoring of interphasial chemistry by introducing a new solvation center represents a fundamental breakthrough in manipulating interfacial reactions that once were elusive to control.
C1 [Xiang, Hongfa; Bhattacharya, Priyanka; Cao, Ruiguo; Zhang, Ji-Guang; Xu, Wu] Pacific NW Natl Lab, Energy & Environm Directorate, Richland, WA 99354 USA.
[Mei, Donghai] Pacific NW Natl Lab, Fundamental & Computat Sci Directorate, Richland, WA 99354 USA.
[Yan, Pengfei; Burton, Sarah D.; Engelhard, Mark H.; Bowden, Mark E.; Zhu, Zihua; Wang, Chong-Min] Pacific NW Natl Lab, Environm & Mol Sci Lab, Richland, WA 99354 USA.
[Xiang, Hongfa] Hefei Univ Technol, Sch Mat Sci & Engn, Hefei 230009, Anhui, Peoples R China.
[Cresce, Arthur von Wald; Xu, Kang] US Army, Res Lab, Sensor & Elect Devices Directorate, Adelphi, MD 20783 USA.
[Polzin, Bryant J.] Argonne Natl Lab, Chem Sci & Engn Div, Argonne, IL 60439 USA.
RP Xu, W (reprint author), Pacific NW Natl Lab, Energy & Environm Directorate, Richland, WA 99354 USA.
EM wu.xu@pnnl.gov
RI Mei, Donghai/D-3251-2011; yan, pengfei/E-4784-2016; Mei,
Donghai/A-2115-2012; Zhu, Zihua/K-7652-2012; Cao, Ruiguo/O-7354-2016;
Xiang, Hongfa/I-5126-2012;
OI yan, pengfei/0000-0001-6387-7502; Mei, Donghai/0000-0002-0286-4182;
Xiang, Hongfa/0000-0002-6182-1932; Xu, Wu/0000-0002-2685-8684;
Engelhard, Mark/0000-0002-5543-0812
FU Office of Vehicle Technologies, the Advanced Battery Materials Research
(BMR) programs of the U.S. Department of Energy (DOE)
[DE-AC02-05CH11231, 18769]; DOE's Office of Biological and Environmental
Research; Pacific Northwest National Laboratory (PNNL); National Science
Foundation of China [21006033, 51372060]; Fundamental Research Funds for
the Central Universities [2013HGCH0002]; U.S. DOE [DE-EE0006543]; DOE
[DE-AC05-76RLO1830]
FX This work was supported by the Assistant Secretary for Energy Efficiency
and Renewable Energy, Office of Vehicle Technologies, the Advanced
Battery Materials Research (BMR) programs of the U.S. Department of
Energy (DOE) under contract no. DE-AC02-05CH11231, subcontract no.
18769. The microscopic images and spectroscopic measurements were
conducted in the William R. Wiley Environmental Molecular Sciences
Laboratory, a national scientific user facility sponsored by the DOE's
Office of Biological and Environmental Research and located at Pacific
Northwest National Laboratory (PNNL). Computing time was granted by the
National Energy Research Scientific Computing Center. We thank Mr. Yufan
Zhou for help in the ToF-SIMS analysis. H.X. acknowledged financial
support from the National Science Foundation of China (Grant nos.
21006033 and 51372060) and Fundamental Research Funds for the Central
Universities (2013HGCH0002). P.B. gratefully acknowledged support from
the Linus Pauling distinguished Postdoctoral Fellowship from PNNL. K.X.
acknowledged the support from U.S. DOE under the Interagency Agreement
no. DE-EE0006543. PNNL is operated by Battelle for the DOE under
contract DE-AC05-76RLO1830.
NR 26
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Z9 5
U1 10
U2 38
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1944-8244
J9 ACS APPL MATER INTER
JI ACS Appl. Mater. Interfaces
PD SEP 23
PY 2015
VL 7
IS 37
BP 20687
EP 20695
DI 10.1021/acsami.5b05552
PG 9
WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary
SC Science & Technology - Other Topics; Materials Science
GA CS2WB
UT WOS:000361931600024
PM 26369297
ER
PT J
AU Zander, NE
Sweetser, D
Cole, DP
Gillan, M
AF Zander, Nicole E.
Sweetser, Daniel
Cole, Daniel P.
Gillan, Margaret
TI Formation of Nanofibers from Pure and Mixed Waste Streams Using
Electrospinning
SO INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
LA English
DT Article
ID MECHANICAL-PROPERTIES; EXPANDED POLYSTYRENE; FIBERS; SCAFFOLDS; SOLVENT
AB New methods are needed to reprocess the excess of plastics in the waste stream. In this work, bottle-grade polyethylene terephthalate (PET), Styrofoam, and polycarbonate from compact discs (CDs) were spun into nanofibers as fine as ca. 100 nm in diameter using the electrospinning technique. The mechanical properties of the fibers were evaluated using microtensile testing. The elastic moduli ranged from 15 to 60 MPa, and displayed stiffnesses comparable or greater than fibers made from commercial polymers of equivalent molecular weight. Nanofibers were also prepared from blends of Styrofoam and recycled polycarbonate. Recycled PET fibers were tested for application in water filtration and had greater than 99% filtration efficiency of 1 mu m particles. Nanofibers from both pure and mixed waste streams are expected to have applications in myriad areas such as ultra/microfiltration, composites, and tissue engineering.
C1 [Zander, Nicole E.; Sweetser, Daniel; Gillan, Margaret] US Army Res Lab, Weapons & Mat Res Directorate, Aberdeen Proving Ground, Aberdeen, MD 21005 USA.
[Cole, Daniel P.] US Army Res Lab, Vehicle Technol Directorate, Aberdeen Proving Ground, Aberdeen, MD 21005 USA.
RP Zander, NE (reprint author), US Army Res Lab, Weapons & Mat Res Directorate, Aberdeen Proving Ground, Aberdeen, MD 21005 USA.
EM nicole.e.zander.civ@mail.mil
FU Postgraduate Research Participation Program at the U.S. Army Research
Laboratory
FX This research was supported in part by an appointment to the
Postgraduate Research Participation Program at the U.S. Army Research
Laboratory administered by the Oak Ridge Institute for Science and
Education through an interagency agreement between the U.S. Department
of Energy and USARL.
NR 31
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Z9 2
U1 4
U2 21
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0888-5885
J9 IND ENG CHEM RES
JI Ind. Eng. Chem. Res.
PD SEP 23
PY 2015
VL 54
IS 37
BP 9057
EP 9063
DI 10.1021/acs.iecr.5b02279
PG 7
WC Engineering, Chemical
SC Engineering
GA CS2VI
UT WOS:000361929700001
ER
PT J
AU Rhon, D
Fritz, J
AF Rhon, Daniel
Fritz, Julie
TI COMParative Early Treatment Effectiveness between physical therapy and
usual care for low back pain (COMPETE): study protocol for a randomized
controlled trial
SO TRIALS
LA English
DT Article
ID EPWORTH SLEEPINESS SCALE; OPERATION-IRAQI-FREEDOM; FEAR-AVOIDANCE
BELIEFS; CATASTROPHIZING SCALE; CLINICAL-TRIALS; HEALTH-STATUS;
DISABILITY; RELIABILITY; IMPACT; COSTS
AB Background: Low back pain is among the leading causes of medical visits and lost duty days among members of the United States Armed Forces and represents the highest 5-year risk of permanent disability in the US Army. For certain elements of care, the timing may be just as important as the type of care. The purpose of this study is to assess the impact of the timing of access to a physical therapist by patients with low back pain, by looking at outcomes and low back pain-related healthcare utilization over a 1-year period.
Methods/Design: This trial will be a two-arm pragmatic randomized clinical trial occurring at two different clinical sites in the Military Health System. We will assess outcomes and related downstream costs for patients who access physical therapy at the primary care level compared to those that receive usual care only. There will be 220 consecutive patients randomized to receive care in either group (early physical therapy or usual care only) for the first 4 weeks, and these patients will then be allowed to receive any additional care dictated by their primary care provider for the following year. The primary outcome measure is the Oswestry Disability Index. Secondary outcome measures are the Global Rating of Change, Patient Satisfaction and 1-year healthcare utilization. Follow-ups will occur at 4 weeks, 3 months and 1 year.
Discussion: This trial takes a pragmatic approach to delivering care by enabling a usual care environment for managing low back pain, while also allowing immediate access to physical therapy. After the initial intervention, the patient's primary provider can continue to manage the patient as he/she normally would in practice. The Military Health System Data Repository will capture all low back pain-related healthcare utilization that occurs in order to allow for a comparison between groups. Analysis from retrospective cohorts has shown improved outcomes and decreased costs for patients that received early versus late physical therapy, but this has yet to be shown in prospective trials.
C1 [Rhon, Daniel] Brooke Army Med Ctr, Ctr Intrepid, Ft Sam Houston, TX 78234 USA.
[Fritz, Julie] Univ Utah, Coll Hlth, Dept Phys Therapy, Salt Lake City, UT 84108 USA.
RP Rhon, D (reprint author), Brooke Army Med Ctr, Ctr Intrepid, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
EM daniel.i.rhon.mil@mail.mil
FU Career Development Award through the Peer Reviewed Orthopedic Research
Program, part of the Congressionally Directed Medical Research Program
[W81XWH-11-1-0657]
FX This project was funded by the Career Development Award through the Peer
Reviewed Orthopedic Research Program, part of the Congressionally
Directed Medical Research Program: Award W81XWH-11-1-0657 (PRORP-CDA).
NR 58
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U1 2
U2 5
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1745-6215
J9 TRIALS
JI Trials
PD SEP 23
PY 2015
VL 16
AR 423
DI 10.1186/s13063-015-0959-8
PG 9
WC Medicine, Research & Experimental
SC Research & Experimental Medicine
GA CR8FZ
UT WOS:000361587800002
PM 26399603
ER
PT J
AU Lazarus, RC
Buonora, JE
Flora, MN
Freedy, JG
Holstein, GR
Martinelli, GP
Jacobowitz, DM
Mueller, GP
AF Lazarus, Rachel C.
Buonora, John E.
Flora, Michael N.
Freedy, James G.
Holstein, Gay R.
Martinelli, Giorgio P.
Jacobowitz, David M.
Mueller, Gregory P.
TI Protein citrullination: a proposed mechanism for pathology in traumatic
brain injury
SO FRONTIERS IN NEUROLOGY
LA English
DT Article
DE traumatic brain injury; citrullination; astrocytes; calcium; glial
fibrillary acidic protein
ID CENTRAL-NERVOUS-SYSTEM; PEPTIDYLARGININE DEIMINASE; MULTIPLE-SCLEROSIS;
RHEUMATOID-ARTHRITIS; MOLECULAR-MECHANISMS; HIPPOCAMPAL-NEURONS;
DISEASE; CALCIUM; PATHOGENESIS; ASTROCYTES
AB Protein citrullination is a calcium-driven post-translational modification proposed to play a causative role in the neurodegenerative disorders of Alzheimer's disease, multiple sclerosis (MS), and prion disease. Citrullination can result in the formation of antigenic epitopes that underlie pathogenic autoimmune responses. This phenomenon, which is best understood in rheumatoid arthritis, may play a role in the chronic dysfunction following traumatic brain injury (TBI). Despite substantial evidence of aberrations in calcium signaling following TBI, there is little understanding of how TBI alters citrullination in the brain. The present investigation addressed this gap by examining the effects of TBI on the distribution of protein citrullination and on the specific cell types involved. Immunofluorescence revealed that controlled cortical impact in rats profoundly upregulated protein citrullination in the cerebral cortex, external capsule, and hippocampus. This response was exclusively seen in astrocytes; no such effects were observed on the status of protein citrullination in neurons, oligodendrocytes or microglia. Further, proteomic analyses demonstrated that the effects of TBI on citrullination were confined to a relatively small subset of neural proteins. Proteins most notably affected were those also reported to be citrullinated in other disorders, including prion disease and MS. In vivo findings were extended in an in vitro model of simulated TBI employing normal human astrocytes. Pharmacologically induced calcium excitotoxicity was shown to activate the citrullination and breakdown of glial fibrillary acidic protein, producing a novel candidate TBI biomarker and potential target for autoimmune recognition. In summary, these findings demonstrate that the effects of TBI on protein citrullination are selective with respect to brain region, cell type, and proteins modified, and may contribute to a role for autoimmune dysfunction in chronic pathology following TBI.
C1 [Lazarus, Rachel C.; Jacobowitz, David M.; Mueller, Gregory P.] Uniformed Serv Univ Hlth Sci, Program Neurosci, Bethesda, MD 20814 USA.
[Buonora, John E.] US Army, Grad Program Anesthesia Nursing, Ft Sam Houston, TX USA.
[Flora, Michael N.; Freedy, James G.; Jacobowitz, David M.; Mueller, Gregory P.] Uniformed Serv Univ Hlth Sci, Dept Anat Physiol & Genet, Bethesda, MD 20814 USA.
[Holstein, Gay R.; Martinelli, Giorgio P.] Icahn Sch Med Mt Sinai, Dept Neurol, New York, NY 10029 USA.
[Mueller, Gregory P.] Uniformed Serv Univ Hlth Sci, Ctr Neurosci & Regenerat Med, Bethesda, MD 20814 USA.
RP Mueller, GP (reprint author), Uniformed Serv Univ Hlth Sci, C2117,4301 Jones Bridge Rd, Bethesda, MD 20814 USA.
EM gregory.mueller@usuhs.edu
FU Defense Medical Research and Development Program, Department of Defense
in the Center for Neuroscience and Regenerative Medicine [G1703D,
D61_I_10_J6_152]; Uniformed Services University of the Health Sciences
[T0702554, R07028414]
FX The authors would like to acknowledge the expert technical assistance of
Ms. Tinghua Chen. Support for this work included a grant from the
Defense Medical Research and Development Program (D61_I_10_J6_152),
Department of Defense in the Center for Neuroscience and Regenerative
Medicine (G1703D) as well as funding from the Uniformed Services
University of the Health Sciences (T0702554 and R07028414).
NR 49
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U1 0
U2 1
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015,
SWITZERLAND
SN 1664-2295
J9 FRONT NEUROL
JI Front. Neurol.
PD SEP 22
PY 2015
VL 6
AR 204
DI 10.3389/fneur.2015.00204
PG 14
WC Clinical Neurology; Neurosciences
SC Neurosciences & Neurology
GA CV0HP
UT WOS:000363931500001
PM 26441823
ER
PT J
AU Li, YF
Liu, Y
Savage, AM
Beyer, FL
Seifert, S
Herring, AM
Knauss, DM
AF Li, Yifan
Liu, Ye
Savage, Alice M.
Beyer, Frederick L.
Seifert, Soenke
Herring, Andrew M.
Knauss, Daniel M.
TI Polyethylene-Based Block Copolymers for Anion Exchange Membranes
SO MACROMOLECULES
LA English
DT Article
ID ALKALINE FUEL-CELLS; DIBLOCK COPOLYMERS; FUNCTIONALIZED POLYETHYLENE;
CONDUCTIVITY; POLYMERIZATION; IONOMER; POLYISOPRENES; HYDROXIDE;
AMMONIUM; CRYSTALLIZATION
AB Block copolymer membranes with a semicrystalline polyethylene component were prepared by anionic polymerization and postpolymerization functionalization reactions. Polybutadiene-b-poly(4-methylstyrene) (PB-b-P4MS) precursors with four different block compositions and 92-95% 1,4-content in the polybutadiene block were produced by living anionic polymerization in a nonpolar solvent. The polybutadiene block was subsequently hydrogenated to prepare a polyethylene block, and the hydrogenated block copolymers were then brominated at the arylmethyl group of the P4MS block. Subsequent quaternization reaction with trimethylamine led to the anion exchange membranes. The degree of crystallinity in the polyethylene block was determined by differential scanning calorimetry to be approximately 24-27%. The postpolymerization modification reactions were examined by H-1 NMR and IR spectroscopy. The amount of quaternary ammonium groups was quantified by ion exchange capacity (IEC) measurements. Membranes with IEC's ranging from 1.17 to 1.92 mmol/g were prepared, The IEC was varied by changing the relative amount of P4MS in the precursor block copolymer, and water uptake and ionic conductivity were found to increase with increasing IEC. Small-angle Xray scattering (SAXS) experiments and transmission electron microscopy (TEM) showed phase-separated, bicontinuous structures at all compositions. Materials with higher IEC show improved ionic conductivity as well as lower activation energy of ion conduction compared to less functionalized membranes. The hydroxide conductivity of the block copolymer membrane with an IEC of 1.92 mmol/g reached 73 mS/cm at 60 degrees C in water. Tensile measurements indicated excellent mechanical properties of the semicrystalline membranes for potential use as alkaline fuel cell membrane materials.
C1 [Li, Yifan; Knauss, Daniel M.] Colorado Sch Mines, Dept Chem & Geochem, Golden, CO 80401 USA.
[Liu, Ye; Herring, Andrew M.] Colorado Sch Mines, Dept Chem & Biol Engn, Golden, CO 80401 USA.
[Savage, Alice M.; Beyer, Frederick L.] US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
[Seifert, Soenke] Argonne Natl Lab, Xray Sci Div, Argonne, IL 60439 USA.
RP Knauss, DM (reprint author), Colorado Sch Mines, Dept Chem & Geochem, Golden, CO 80401 USA.
EM dknauss@mines.edu
OI Li, Yifan/0000-0002-9142-0232; Herring, Andrew/0000-0001-7318-5999
FU Army Research Office through a MURI [W911NF-10-1-0520]; NSF MRI program
[CHW-0923537]; DOE Office of Science by Argonne National Laboratory
[DE-AC02-06CH11357]; Postgraduate Research Participation Program at the
US Army Research Laboratory [ORISE1120-1120-99]
FX This work was funded by the Army Research Office through a MURI (grant #
W911NF-10-1-0520). NMR spectroscopy was made possible through a grant
from the NSF MRI program (grant # CHW-0923537). This research used
resources of the Advanced Photon Source, a U.S. Department of Energy
(DOE) Office of Science User Facility operated for the DOE Office of
Science by Argonne National Laboratory under Contract No.
DE-AC02-06CH11357. A.M.S. was supported by the Postgraduate Research
Participation Program at the US Army Research Laboratory, administered
by the Oak Ridge Institute of Science and Education through an
interagency agreement between the US Department of Energy and Army
Research Laboratory (Contract ORISE1120-1120-99). The authors also want
to thank Blake Whitley and Prof. Kip Findley for their assistance with
membrane tensile testing and Drs. Scott Walck and Aaron Jackson for
assistance with transmission electron microscopy.
NR 66
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Z9 12
U1 21
U2 84
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0024-9297
EI 1520-5835
J9 MACROMOLECULES
JI Macromolecules
PD SEP 22
PY 2015
VL 48
IS 18
BP 6523
EP 6533
DI 10.1021/acs.macromol.5b01457
PG 11
WC Polymer Science
SC Polymer Science
GA CS2XP
UT WOS:000361935600019
ER
PT J
AU Kumar, R
Ray, PC
Datta, D
Bansal, GP
Angov, E
Kumar, N
AF Kumar, Rajesh
Ray, Paresh C.
Datta, Dibyadyuti
Bansal, Geetha P.
Angov, Evelina
Kumar, Nirbhay
TI Nanovaccines for malaria using Plasmodium falciparum antigen Pfs25
attached gold nanoparticles
SO VACCINE
LA English
DT Article
DE Malaria; Vaccine; Gold nanoparticles; Transmission
ID TRANSMISSION-BLOCKING IMMUNITY; GAMETE-SURFACE PROTEIN; CELL-FREE
SYSTEM; VACCINE CANDIDATE; DRUG-DELIVERY; IN-VIVO; ESCHERICHIA-COLI;
SEXUAL STAGES; ANTIBODIES; ADJUVANTS
AB Malaria transmission-blocking vaccines (TBV) targeting sexual stages of the parasite represent an ideal intervention to reduce the burden of the disease and eventual elimination at the population level in endemic regions. Immune responses against sexual stage antigens impair the development of parasite inside the mosquitoes. Target antigens identified in Plasmodium falciparum include surface proteins Pfs230 and Pfs48/45 in male and female gametocytes and Pfs25 expressed in zygotes and ookinetes. The latter has undergone extensive evaluation in pre-clinical and phase I clinical trials and remains one of the leading target antigens for the development of TBV. Pfs25 has a complex tertiary structure characterized by four EGF-like repeat motifs formed by 11 disulfide bonds, and it has been rather difficult to obtain Pfs25 as a homogenous product in native conformation in any heterologous expression system. Recently, we have reported expression of codon-harmonized recombinant Pfs25 in Escherichia coil (CHrPfs25) and which elicited highly potent malaria transmission-blocking antibodies in mice. In the current study, we investigated CHrPfs25 along with gold nanoparticles of different shapes, size and physicochemical properties as adjuvants for induction of transmission blocking immunity. The results revealed that CHrPfs25 delivered with various gold nanoparticles elicited strong transmission blocking antibodies and suggested that gold nanoparticles based formulations can be developed as nanovaccines to enhance the immunogenicity of vaccine antigens. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Kumar, Rajesh; Datta, Dibyadyuti; Bansal, Geetha P.; Kumar, Nirbhay] Tulane Univ, Dept Trop Med, New Orleans, LA 70112 USA.
[Kumar, Rajesh; Datta, Dibyadyuti; Bansal, Geetha P.; Kumar, Nirbhay] Tulane Univ, Vector Borne Infect Dis Res Ctr, Sch Publ Hlth & Trop Med, New Orleans, LA 70112 USA.
[Ray, Paresh C.] Jackson State Univ, Dept Chem & Biochem, Jackson, MS 39217 USA.
[Angov, Evelina] Walter Reed Army Inst Res, Silver Spring, MD USA.
RP Kumar, N (reprint author), Tulane Univ, Dept Trop Med, New Orleans, LA 70112 USA.
EM nkumar@tulane.edu
FU NIH [R21-AI101427, RO1-AI47089]
FX These studies were supported by NIH grants R21-AI101427 and RO1-AI47089.
NR 67
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U1 5
U2 14
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0264-410X
EI 1873-2518
J9 VACCINE
JI Vaccine
PD SEP 22
PY 2015
VL 33
IS 39
BP 5064
EP 5071
DI 10.1016/j.vaccine.2015.08.025
PG 8
WC Immunology; Medicine, Research & Experimental
SC Immunology; Research & Experimental Medicine
GA CS1XT
UT WOS:000361862900007
PM 26299750
ER
PT J
AU Jurczak, P
Onno, A
Sablon, K
Liu, HY
AF Jurczak, Pamela
Onno, Arthur
Sablon, Kimberly
Liu, Huiyun
TI Efficiency of GaInAs thermophotovoltaic cells: the effects of incident
radiation, light trapping and recombinations
SO OPTICS EXPRESS
LA English
DT Article
ID MOLECULAR-BEAM EPITAXY; SOLAR-CELLS; DEVICES; INASYP1-Y; ARSENIDE
AB The radiative limit model, based on the black body theory extended to semiconductors and the flow equilibrium in the cell, has been adapted for GaxIn1-xAs thermophotovoltaic devices. The impact of the thermal emitter temperature and the incident power density on the performance of cells for different Ga/In ratios has been investigated. The effects of the thickness of the cell and of light trapping have been investigated as well. A theoretical maximum efficiency of 24.2% has been calculated for a dislocation-free 5-mu m-thick cell with a 0.43 eV bandgap illuminated by a source at 1800 K. The model also takes into account Auger recombinations and threading dislocations-related Shockley-Read-Hall recombinations. (C) 2015 Optical Society of America
C1 [Jurczak, Pamela; Onno, Arthur; Liu, Huiyun] UCL, Dept Elect & Elect Engn, London WC1E 7JE, England.
[Sablon, Kimberly] US Army Res Lab, Adelphi, MD 20783 USA.
RP Jurczak, P (reprint author), UCL, Dept Elect & Elect Engn, Torrington Pl, London WC1E 7JE, England.
EM pamela.jurczak.10@ucl.ac.uk
FU US Army International Technology Center-Atlantic; Royal Society
FX The authors acknowledge the financial support of US Army International
Technology Center-Atlantic. H. Liu would like to thank The Royal Society
for funding his University Research Fellowship.
NR 23
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U1 2
U2 14
PU OPTICAL SOC AMER
PI WASHINGTON
PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA
SN 1094-4087
J9 OPT EXPRESS
JI Opt. Express
PD SEP 21
PY 2015
VL 23
IS 19
BP A1208
EP A1219
DI 10.1364/OE.23.0A1208
PG 12
WC Optics
SC Optics
GA CW5ZQ
UT WOS:000365076400018
PM 26406750
ER
PT J
AU Carvillo, P
Chen, Y
Boyle, C
Barnes, PN
Song, XY
AF Carvillo, Paulo
Chen, Yun
Boyle, Cullen
Barnes, Paul N.
Song, Xueyan
TI Thermoelectric Performance Enhancement of Calcium Cobaltite through
Barium Grain Boundary Segregation
SO INORGANIC CHEMISTRY
LA English
DT Article
ID CA3CO4O9 CERAMICS; TEMPERATURE; OXIDE; SYSTEM; CA
AB We report the dramatic increase of the Seebeck coefficient S and thermoelectric performance of calcium cobaltite Ca3Co4O9+delta ceramics through non-stoichiometric addition of minute amount of Ba. The nominal chemistry of polycrystal pellets are Ca3BaxCo4O9+delta (x = 0, 0.01, 0.05, and 0.1). At 323 K, S of Ca3Co4O9+delta is 135 mu V K-1, whereas S of Ba incorporated Ca3Ba0.05Co4O9+delta is 162.5 mu V.K-1, which is the highest S value near room temperature regime reported for calcium cobaltite. The increase of S for Ca3Ba0.05Co4O9+delta sample is accompanied by the decrease of the electrical resistivity rho, resulting in high power factor S-2/rho of 843 mu W.m(-1) K-2 at 1007 K. Moreover, the thermal conductivities kappa of Ca3Ba0.05Co4O9+delta decrease with the increase of the Ba addition. The figure-of-merit ZT for Ca3Ba0.05Co4O9+delta reaches 0.52 at 1073 K and a factor of 2.5 increment in comparison with undoped Ca3Co4O9+delta. Nanostructure examinations show that the added Ba segregated at the Ca3Co4O9+delta grain boundaries, while the Ca3Co4O9+delta grain interior is free of Ba. Performance enhancement is attributed to the carrier filtering effect caused by the Ba segregation. In addition, Ba segregation promotes the better crystal alignment and the development of crystal texture.
C1 [Carvillo, Paulo; Chen, Yun; Boyle, Cullen; Song, Xueyan] W Virginia Univ, Dept Mech & Aerosp Engn, Morgantown, WV 26506 USA.
[Barnes, Paul N.] Army Res Lab, Adelphi, MD 20783 USA.
RP Song, XY (reprint author), W Virginia Univ, Dept Mech & Aerosp Engn, Evansdale Dr, Morgantown, WV 26506 USA.
EM xueyan.song@mail.wvu.edu
FU National Science Foundation DMR [1254594]
FX P.C., C.B., and X.S. greatly appreciate the support from the National
Science Foundation DMR (1254594).
NR 27
TC 1
Z9 1
U1 7
U2 41
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0020-1669
EI 1520-510X
J9 INORG CHEM
JI Inorg. Chem.
PD SEP 21
PY 2015
VL 54
IS 18
BP 9027
EP 9032
DI 10.1021/acs.inorgchem.5b01296
PG 6
WC Chemistry, Inorganic & Nuclear
SC Chemistry
GA CS1YU
UT WOS:000361865600025
PM 26357956
ER
PT J
AU Bankowski, E
Meitzler, T
Khymyn, RS
Tiberkevich, VS
Slavin, AN
Tang, HX
AF Bankowski, Elena
Meitzler, Thomas
Khymyn, Roman S.
Tiberkevich, Vasil S.
Slavin, Andrei N.
Tang, Hong X.
TI Magnonic crystal as a delay line for low-noise auto-oscillators
SO APPLIED PHYSICS LETTERS
LA English
DT Article
AB It is demonstrated that a delay line based on a one-dimensional magnonic crystal used in a feedback loop of a microwave auto-oscillator can substantially reduce the phase noise figure and improve other vital performance characteristics of the auto-oscillator. The advantage is achieved due to the increase of the effective delay time in the magnonic crystal, compared to the case of an unpatterned yttrium iron garnet (YIG) film, and improvement of the power-handling characteristics due to the now possible increase of the YIG film thickness. The internal modes of a magnonic crystal caused by the periodic energy exchange between the incident and reflected spin waves play the dominant role in the described effect. (C) 2015 AIP Publishing LLC.
C1 [Bankowski, Elena; Meitzler, Thomas] US Army TARDEC, Warren, MI 48397 USA.
[Khymyn, Roman S.; Tiberkevich, Vasil S.; Slavin, Andrei N.] Oakland Univ, Dept Phys, Rochester, MI 48309 USA.
[Tang, Hong X.] Yale Univ, Dept Elect Engn, New Haven, CT 06511 USA.
RP Khymyn, RS (reprint author), Oakland Univ, Dept Phys, Rochester, MI 48309 USA.
EM khiminr@gmail.com
RI Meitzler, Thomas/D-1065-2017;
OI Tiberkevich, Vasil/0000-0002-8374-2565
FU DARPA MTO/MESO [N66001-11-1-4114]; U.S. Army Contract from TARDEC,
RDECOM; National Science Foundation of the USA [1015175, 1305574]
FX This work has been supported by the DARPA MTO/MESO Grant No.
N66001-11-1-4114, by the U.S. Army Contract from TARDEC, RDECOM, and by
the Grant Nos. 1015175 and 1305574 from the National Science Foundation
of the USA.
NR 20
TC 1
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U1 3
U2 11
PU AMER INST PHYSICS
PI MELVILLE
PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA
SN 0003-6951
EI 1077-3118
J9 APPL PHYS LETT
JI Appl. Phys. Lett.
PD SEP 21
PY 2015
VL 107
IS 12
AR 122409
DI 10.1063/1.4931758
PG 4
WC Physics, Applied
SC Physics
GA CS1NI
UT WOS:000361832600039
ER
PT J
AU Yoganandan, N
Pintar, FA
Schlick, M
Humm, JR
Voo, L
Merkle, A
Kleinberger, M
AF Yoganandan, Narayan
Pintar, Frank A.
Schlick, Michael
Humm, John R.
Voo, Liming
Merkle, Andrew
Kleinberger, Michael
TI Vertical accelerator device to apply loads simulating blast environments
in the military to human surrogates
SO JOURNAL OF BIOMECHANICS
LA English
DT Article
DE Vertical loading; Military events; Under-body blasts; Impact
biomechanics
ID BIOMECHANICS
AB The objective of the study was to develop a simple device, Vertical accelerator (Vertac), to apply vertical impact loads to Post Mortem Human Subject (PMHS) or dummy surrogates because injuries sustained in military conflicts are associated with this vector; example, under-body blasts from explosive devices/events. The two-part mechanically controlled device consisted of load-application and load-receiving sections connected by a lever arm. The former section incorporated a falling weight to impact one end of the lever arm inducing a reaction at the other/load-receiving end. The "launch-plate" on this end of the arm applied the vertical impact load/acceleration pulse under different initial conditions to biological/physical surrogates, attached to second section. It is possible to induce different acceleration pulses by using varying energy absorbing materials and controlling drop height and weight. The second section of Vertac had the flexibility to accommodate different body regions for vertical loading experiments. The device is simple and inexpensive. It has the ability to control pulses and flexibility to accommodate different sub-systems/components of human surrogates. It has the capability to incorporate preloads and military personal protective equipment (e.g., combat helmet). It can simulate vehicle roofs. The device allows for intermittent specimen evaluations (x-ray and palpation, without changing specimen alignment). The two free but interconnected sections can be used to advance safety to military personnel. Examples demonstrating feasibilities of the Vertac device to apply vertical impact accelerations using PMHS head-neck preparations with helmet and booted Hybrid III dummy lower leg preparations under in-contact and launch-type impact experiments are presented. Published by Elsevier Ltd.
C1 [Yoganandan, Narayan; Pintar, Frank A.; Schlick, Michael; Humm, John R.] Med Coll Wisconsin, Dept Neurosurg, Milwaukee, WI 53226 USA.
[Voo, Liming; Merkle, Andrew] Johns Hopkins Univ, Appl Phys Lab, Laurel, MD USA.
[Kleinberger, Michael] US Army Res Lab, Soldier Protect Sci Branch, Aberdeen Proving Ground, MD USA.
RP Yoganandan, N (reprint author), Med Coll Wisconsin, Chair Biomed Engn, Dept Neurosurg, 9200 West Wisconsin Ave, Milwaukee, WI 53226 USA.
EM yoga@mcw.edu
FU Department of Veterans Affairs Medical Research [W81XWH-10-2-0065,
W81XWH-12-0041]; Department of Neurosurgery at the Medical College of
Wisconsin
FX This research was supported in part by the Cooperative Agreements
W81XWH-10-2-0065 and W81XWH-12-0041 (Warrior Injury Assessment Manikin
study), Department of Veterans Affairs Medical Research and Department
of Neurosurgery at the Medical College of Wisconsin. This material is
the result of work supported with resources and use of facilities at the
Zablocki VA Medical Center, Milwaukee, Wisconsin and Medical College of
Wisconsin. The first four authors are part-time employees of the
Zablocki VA Medical Center, Milwaukee, Wisconsin. Any views expressed in
this article are those of the authors and not necessarily representative
of the funding organizations.
NR 18
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U1 2
U2 2
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0021-9290
EI 1873-2380
J9 J BIOMECH
JI J. Biomech.
PD SEP 18
PY 2015
VL 48
IS 12
BP 3534
EP 3538
DI 10.1016/j.jbiomech.2015.06.008
PG 5
WC Biophysics; Engineering, Biomedical
SC Biophysics; Engineering
GA CT8ME
UT WOS:000363069900084
PM 26159057
ER
PT J
AU Das, S
Rundell, MS
Mirza, AH
Pingle, MR
Shigyo, K
Garrison, AR
Paragas, J
Smith, SK
Olson, VA
Larone, DH
Spitzer, ED
Barany, F
Golightly, LM
AF Das, Sanchita
Rundell, Mark S.
Mirza, Aashiq H.
Pingle, Maneesh R.
Shigyo, Kristi
Garrison, Aura R.
Paragas, Jason
Smith, Scott K.
Olson, Victoria A.
Larone, Davise H.
Spitzer, Eric D.
Barany, Francis
Golightly, Linnie M.
TI A Multiplex PCR/LDR Assay for the Simultaneous Identification of
Category A Infectious Pathogens: Agents of Viral Hemorrhagic Fever and
Variola Virus
SO PLOS ONE
LA English
DT Article
ID LIGASE DETECTION REACTION; REVERSE-TRANSCRIPTASE PCR;
POLYMERASE-CHAIN-REACTION; EBOLA-VIRUS; BIOTERRORISM AGENTS;
SMALLPOX-VIRUS; DIAGNOSIS; DISEASE; DNA; OUTBREAK
AB CDC designated category A infectious agents pose a major risk to national security and require special action for public health preparedness. They include viruses that cause viral hemorrhagic fever (VHF) syndrome as well as variola virus, the agent of smallpox. VHF is characterized by hemorrhage and fever with multi-organ failure leading to high morbidity and mortality. Smallpox, a prior scourge, has been eradicated for decades, making it a particularly serious threat if released nefariously in the essentially non-immune world population. Early detection of the causative agents, and the ability to distinguish them from other pathogens, is essential to contain outbreaks, implement proper control measures, and prevent morbidity and mortality. We have developed a multiplex detection assay that uses several species-specific PCR primers to generate amplicons from multiple pathogens; these are then targeted in a ligase detection reaction (LDR). The resultant fluorescently-labeled ligation products are detected on a universal array enabling simultaneous identification of the pathogens. The assay was evaluated on 32 different isolates associated with VHF (ebolavirus, marburgvirus, Crimean Congo hemorrhagic fever virus, Lassa fever virus, Rift Valley fever virus, Dengue virus, and Yellow fever virus) as well as variola virus and vaccinia virus (the agent of smallpox and its vaccine strain, respectively). The assay was able to detect all viruses tested, including 8 sequences representative of different variola virus strains from the CDC repository. It does not cross react with other emerging zoonoses such as monkeypox virus or cowpox virus, or six flaviviruses tested (St. Louis encephalitis virus, Murray Valley encephalitis virus, Powassan virus, Tick-borne encephalitis virus, West Nile virus and Japanese encephalitis virus).
C1 [Das, Sanchita; Shigyo, Kristi; Golightly, Linnie M.] Cornell Univ, Dept Med, Div Infect Dis, Weill Med Coll, New York, NY 10021 USA.
[Rundell, Mark S.; Mirza, Aashiq H.; Pingle, Maneesh R.; Larone, Davise H.; Barany, Francis; Golightly, Linnie M.] Cornell Univ, Dept Microbiol & Immunol, Weill Med Coll, New York, NY 10021 USA.
[Garrison, Aura R.] US Army Med Res Inst Infect Dis, Frederick, MD USA.
[Paragas, Jason] NIAID, Integrated Res Facil, Div Clin Res, NIH, Ft Detrick, MD USA.
[Smith, Scott K.; Olson, Victoria A.] Ctr Dis Control & Prevent, Poxvirus Team, Poxvirus & Rabies Branch,Natl Ctr Emerging Zoonot, Div High Consequence Pathogens & Pathol, Atlanta, GA USA.
[Larone, Davise H.] Cornell Univ, Weill Med Coll, Dept Pathol & Lab Med, New York, NY 10021 USA.
[Spitzer, Eric D.] SUNY Stony Brook, Dept Pathol, Med Ctr, Stony Brook, NY 11794 USA.
RP Golightly, LM (reprint author), Cornell Univ, Dept Med, Div Infect Dis, Weill Med Coll, New York, NY 10021 USA.
EM lgolight@med.cornell.edu
FU National Institute of Allergy and Infectious Diseases of the National
Institute of Health [UC1-AI062579]
FX This work was supported by contract UC1-AI062579 awarded to FB by the
National Institute of Allergy and Infectious Diseases of the National
Institute of Health (http://www.niaid.nih.gov/Pages/default.aspx). The
funders had no role in study design, data collection and analysis,
decision to publish, or preparation of the manuscript. At no time during
the study did they receive salary support, other funds, or research
materials from Beckman Coulter or Coferon Inc. to support the study, nor
do either of these entities have any commercial rights or interest in
developing a product from the current study.
NR 57
TC 2
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U1 1
U2 13
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 18
PY 2015
VL 10
IS 9
AR e0138484
DI 10.1371/journal.pone.0138484
PG 16
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CS0ZE
UT WOS:000361790200113
PM 26381398
ER
PT J
AU Katzelnick, LC
Fonville, JM
Gromowski, GD
Arriaga, JB
Green, A
James, SL
Lau, L
Montoya, M
Wang, CL
VanBlargan, LA
Russell, CA
Thu, HM
Pierson, TC
Buchy, P
Aaskov, JG
Munoz-Jordan, JL
Vasilakis, N
Gibbons, RV
Tesh, RB
Osterhaus, ADME
Fouchier, RAM
Durbin, A
Simmons, CP
Holmes, EC
Harris, E
Whitehead, SS
Smith, DJ
AF Katzelnick, Leah C.
Fonville, Judith M.
Gromowski, Gregory D.
Arriaga, Jose Bustos
Green, Angela
James, Sarah L.
Lau, Louis
Montoya, Magelda
Wang, Chunling
VanBlargan, Laura A.
Russell, Colin A.
Thu, Hlaing Myat
Pierson, Theodore C.
Buchy, Philippe
Aaskov, John G.
Munoz-Jordan, Jorge L.
Vasilakis, Nikos
Gibbons, Robert V.
Tesh, Robert B.
Osterhaus, Albert D. M. E.
Fouchier, Ron A. M.
Durbin, Anna
Simmons, Cameron P.
Holmes, Edward C.
Harris, Eva
Whitehead, Stephen S.
Smith, Derek J.
TI Dengue viruses cluster antigenically but not as discrete serotypes
SO SCIENCE
LA English
DT Article
ID REDUCTION NEUTRALIZATION TEST; HEMORRHAGIC-FEVER; INFLUENZA-VIRUS;
ANTIBODY-LEVELS; INFECTION; EVOLUTION; THAILAND; VACCINE;
IDENTIFICATION; FLAVIVIRUSES
AB The four genetically divergent dengue virus (DENV) types are traditionally classified as serotypes. Antigenic and genetic differences among the DENV types influence disease outcome, vaccine-induced protection, epidemic magnitude, and viral evolution. We characterized antigenic diversity in the DENV types by antigenic maps constructed from neutralizing antibody titers obtained from African green monkeys and after human vaccination and natural infections. Genetically, geographically, and temporally, diverse DENV isolates clustered loosely by type, but we found that many are as similar antigenically to a virus of a different type as to some viruses of the same type. Primary infection antisera did not neutralize all viruses of the same DENV type any better than other types did up to 2 years after infection and did not show improved neutralization to homologous type isolates. That the canonical DENV types are not antigenically homogeneous has implications for vaccination and research on the dynamics of immunity, disease, and the evolution of DENV.
C1 [Katzelnick, Leah C.; Fonville, Judith M.; James, Sarah L.; Smith, Derek J.] Univ Cambridge, Dept Zool, Ctr Pathogen Evolut, Cambridge CB2 3EJ, England.
[Katzelnick, Leah C.; Fonville, Judith M.; James, Sarah L.; Smith, Derek J.] World Hlth Org WHO Collaborating Ctr Modeling Evo, Cambridge CB2 3EJ, England.
[Katzelnick, Leah C.; Gromowski, Gregory D.; Arriaga, Jose Bustos; VanBlargan, Laura A.; Pierson, Theodore C.; Whitehead, Stephen S.] NIAID, NIH, Bethesda, MD 20892 USA.
[Katzelnick, Leah C.; Green, Angela; Lau, Louis; Montoya, Magelda; Wang, Chunling; Harris, Eva] Univ Calif Berkeley, Sch Publ Hlth, Div Infect Dis & Vaccinol, Berkeley, CA 94720 USA.
[Fonville, Judith M.; Osterhaus, Albert D. M. E.; Fouchier, Ron A. M.; Smith, Derek J.] Erasmus MC, Dept Virosci, NL-3015 GE Rotterdam, Netherlands.
[Russell, Colin A.] Univ Cambridge, Dept Vet Med, Cambridge CB3 0ES, England.
[Thu, Hlaing Myat] Dept Med Res, Yangon, Myanmar.
[Buchy, Philippe] Reseau Int Inst Pasteur, Inst Pasteur Cambodia, Phnom Penh 12201, Cambodia.
[Aaskov, John G.] Queensland Univ Technol, Inst Hlth & Biomed Innovat, Brisbane, Qld 4001, Australia.
[Aaskov, John G.] Australian Army Malaria Inst, Brisbane, Qld 4051, Australia.
[Munoz-Jordan, Jorge L.] Ctr Dis Control & Prevent, Dengue Branch, Div Vector Borne Dis, San Juan, PR 00971 USA.
[Vasilakis, Nikos; Tesh, Robert B.] Univ Texas Med Branch, Dept Pathol, Galveston, TX 77555 USA.
[Vasilakis, Nikos; Tesh, Robert B.] Univ Texas Med Branch, Ctr Biodef & Emerging Infect Dis, Galveston, TX 77555 USA.
[Vasilakis, Nikos; Tesh, Robert B.] Univ Texas Med Branch, Ctr Trop Dis, Galveston, TX 77555 USA.
[Vasilakis, Nikos; Tesh, Robert B.] Univ Texas Med Branch, Inst Human Infect & Immun, Galveston, TX 77555 USA.
[Gibbons, Robert V.] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand.
[Durbin, Anna] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Int Hlth, Ctr Immunizat Res, Baltimore, MD 21205 USA.
[Simmons, Cameron P.] Univ Oxford, Clin Res Unit, Wellcome Trust Major Overseas Programme, Ho Chi Minh City, Vietnam.
[Simmons, Cameron P.] Univ Oxford, Nuffield Dept Clin Med, Ctr Trop Med, Oxford OX3 7LJ, England.
[Simmons, Cameron P.] Univ Melbourne, Dept Microbiol & Immunol, Parkville, Vic 3010, Australia.
[Holmes, Edward C.] Univ Sydney, Sch Biol Sci, Charles Perkins Ctr, Marie Bashir Inst Infect Dis & Biosecur, Sydney, NSW 2006, Australia.
[Holmes, Edward C.] Univ Sydney, Sydney Med Sch, Sydney, NSW 2006, Australia.
RP Smith, DJ (reprint author), Univ Cambridge, Dept Zool, Ctr Pathogen Evolut, Downing St, Cambridge CB2 3EJ, England.
EM djs200@cam.ac.uk
RI Fouchier, Ron/A-1911-2014;
OI Fouchier, Ron/0000-0001-8095-2869; Simmons, Cameron
P./0000-0002-9039-7392; Holmes, Edward/0000-0001-9596-3552
FU Intramural Research Program of the U.S. NIH; National Institute of
Allergy and Infectious Diseases (NIAID); European Union (EU) [223498,
278976]; Human Frontier Science Program (HFSP) program grant
[P0050/2008]; NIH Director's Pioneer Award [DP1-OD000490-01]; FIRST
program from the Bill and Melinda Gates Foundation; Instituto Carlos
Slim de la Salud; NIAID-NIH Centers of Excellence for Influenza Research
and Surveillance [HHSN266200700010C, HHSN272201400008C]; Gates Cambridge
Scholarship; NIH Oxford Cambridge Scholars Program; Medical Research
Council Fellowship [MR/K021885/1]; Junior Research Fellowship from
Homerton College Cambridge; National Health and Medical Research Council
Australia Fellowship; NIH [HHSN272201000040I/HHSN27200004/D04]; GSK
Pharma; GSK Vaccines; Merck
FX We express our gratitude to the members of the Dengue Antigenic
Cartography Consortium, named in the supplementary materials, for their
advice and contributions to the Consortium to date. We thank D. Burke,
N. Lewis, E. Selkov, E. Skepner, A. Mosterin, R. Mogling, S. Wilks, T.
Kotarba, and V. Duong for their technical expertise. M. Melendrez, J.
Hang, R. Jarman, S. M. Cave, S. G. Widen, T. G. Wood, and V. Duong
assisted with virus sequencing. C. Firestone and M. Galvez assisted with
neutralization assay titrations. This research was supported in part by
the Intramural Research Program of the U.S. NIH, National Institute of
Allergy and Infectious Diseases (NIAID), European Union (EU) FP7
programs EMPERIE (223498) and ANTIGONE (278976), Human Frontier Science
Program (HFSP) program grant P0050/2008, the NIH Director's Pioneer
Award DP1-OD000490-01, the FIRST program from the Bill and Melinda Gates
Foundation, and the Instituto Carlos Slim de la Salud (E.H.). The
antigenic cartography toolkit was in part supported by NIAID-NIH Centers
of Excellence for Influenza Research and Surveillance contracts
HHSN266200700010C and HHSN272201400008C for use on influenza virus.
L.C.K. was supported by the Gates Cambridge Scholarship and the NIH
Oxford Cambridge Scholars Program. J.M.F. was supported by a Medical
Research Council Fellowship (MR/K021885/1) and a Junior Research
Fellowship from Homerton College Cambridge. E.C.H. was supported by an
National Health and Medical Research Council Australia Fellowship. N.V.
and R.B.T were supported by NIH contract
HHSN272201000040I/HHSN27200004/D04. The viruses and sera used in this
study are covered by standard material transfer agreements at the home
institutions of S.S.W., C.P.S., E.H., P.B., J.G.A., J.L.M.J., N.V., and
R.B.T. A.D.M.E.O. is a professor and director of Artemis One Health
Utrecht, The Netherlands; Chief Scientific Officer Viroclinics
Biosciences BV, the Netherlands; and a Board Member of Protein Sciences
USA. P.B. performed this work while at the Institut Pasteur in Cambodia,
but since June 2015, is with GlaxoSmithKline vaccines in Singapore, and
has stock options with GSK. C.P.S. is a paid consultant to GSK Pharma,
GSK Vaccines, and Merck and has received a grant and consulting payments
to his institution from Sanofi Pasteur. The sequences used in this study
are available from GenBank (http://www.ncbi.nlm.nih.gov/genbank/) and
are listed in table S1. Files used for genetic analyses are available as
supplementary data files. The NIH monovalent DENV vaccines trials
(ClinicalTrials.gov identifiers: NCT00473135 NCT00920517, NCT00831012,
NCT00831012) were performed under an investigational new drug
application reviewed by the U.S. Food and Drug Administration and
approved by the Institutional Review Board at the University of Vermont
and Johns Hopkins University. Informed consent was obtained in
accordance federal and international regulations (21CFR50, ICHE6). The
Pediatric Dengue Cohort Study in Managua, Nicaragua, was approved by the
Institutional Review Boards of the Nicaraguan Ministry of Health and the
University of California, Berkeley. Parents or legal guardians of all
subjects provided written informed consent, and subjects 6 years of age
and older provided assent.
NR 41
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Z9 18
U1 4
U2 22
PU AMER ASSOC ADVANCEMENT SCIENCE
PI WASHINGTON
PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA
SN 0036-8075
EI 1095-9203
J9 SCIENCE
JI Science
PD SEP 18
PY 2015
VL 349
IS 6254
BP 1338
EP 1343
DI 10.1126/science.aac5017
PG 6
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CR5CR
UT WOS:000361357700049
PM 26383952
ER
PT J
AU Olson, MA
Lee, MS
Kissner, TL
Alam, S
Waugh, DS
Saikh, KU
AF Olson, Mark A.
Lee, Michael S.
Kissner, Teri L.
Alam, Shahabuddin
Waugh, David S.
Saikh, Kamal U.
TI Discovery of small molecule inhibitors of MyD88-dependent signaling
pathways using a computational screen
SO SCIENTIFIC REPORTS
LA English
DT Article
ID TOLL/INTERLEUKIN-1 RECEPTOR DOMAINS; STAPHYLOCOCCAL-ENTEROTOXIN-B;
TOLL-LIKE RECEPTORS; MHC CLASS-II; TIR-DOMAIN; CRYSTAL-STRUCTURE;
ESCHERICHIA-COLI; STRUCTURAL BASIS; PROTEIN DOCKING; MYD88
AB In this study, we used high-throughput computational screening to discover drug-like inhibitors of the host MyD88 protein-protein signaling interaction implicated in the potentially lethal immune response associated with Staphylococcal enterotoxins. We built a protein-protein dimeric docking model of the Toll-interleukin receptor (TIR)-domain of MyD88 and identified a binding site for docking small molecules. Computational screening of 5 million drug-like compounds led to testing of 30 small molecules; one of these molecules inhibits the TIR-TIR domain interaction and attenuates pro-inflammatory cytokine production in human primary cell cultures. Compounds chemically similar to this hit from the PubChem database were observed to be more potent with improved drug-like properties. Most of these 2nd generation compounds inhibit Staphylococcal enterotoxin B (SEB)-induced TNF-alpha, IFN-gamma, IL-6, and IL-1 beta production at 2-10 mu M in human primary cells. Biochemical analysis and a cell-based reporter assay revealed that the most promising compound, T6167923, disrupts MyD88 homodimeric formation, which is critical for its signaling function. Furthermore, we observed that administration of a single dose of T6167923 completely protects mice from lethal SEB-induced toxic shock. In summary, our in silico approach has identified anti-inflammatory inhibitors against in vitro and in vivo toxin exposure with promise to treat other MyD88-related proinflammatory diseases.
C1 [Olson, Mark A.; Lee, Michael S.] US Army Med Res Inst Infect Dis, Dept Biochem & Cell Biol, Frederick, MD 21702 USA.
[Kissner, Teri L.; Alam, Shahabuddin; Saikh, Kamal U.] US Army Med Res Inst Infect Dis, Mol & Translat Sci Div, Dept Immunol, Frederick, MD 21702 USA.
[Waugh, David S.] NCI, Ctr Macromol Crystallog, Frederick, MD 21702 USA.
[Lee, Michael S.] US Army Res Lab, Computat Sci Div, Aberdeen Proving Ground, MD 21005 USA.
RP Olson, MA (reprint author), US Army Med Res Inst Infect Dis, Dept Biochem & Cell Biol, Frederick, MD 21702 USA.
EM molson@compbiophys.org; kamal.u.saikh.civ@mail.mil
FU United States Defense Threat Reduction Agency [CBM.THROX.03.10.RD.006]
FX This work was supported by the United States Defense Threat Reduction
Agency to K. U. S. (grant CBM.THROX.03.10.RD.006). We gratefully
acknowledge Sreejith Raran-Kurussi and Joseph E. Tropea for their help
in the expression and purification of TIR domain protein of MyD88 used
in this study. We thank Prof. Julius Rebek Jr., Dr. Mitra Rebek, Dr.
Darius Ajami and Dr. Robert G. Ulrich for helpful discussions during the
course of this work. We also thank David Fetterer for statistical
analysis and Lorraine Farinick for preparing the figures. We are also
grateful to the investigators at Addgene for providing plasmids
originally published in Proc. Natl. Acad. Sci. 2006, 103(29): 10961-6.
Computational time was provided by the U. S. Army Research Laboratory
DoD Supercomputing Resource Center.
NR 50
TC 2
Z9 2
U1 4
U2 9
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD SEP 18
PY 2015
VL 5
AR 14246
DI 10.1038/srep14246
PG 14
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CR5HF
UT WOS:000361371000002
PM 26381092
ER
PT J
AU Hao, H
Fountain, MD
Tacer, KF
Xia, F
Bi, WM
Kang, SHL
Patel, A
Rosenfeld, JA
Le Caignec, C
Isidor, B
Krantz, ID
Noon, SE
Pfotenhauer, JP
Morgan, TM
Moran, R
Pedersen, RC
Saenz, MS
Schaaf, CP
Potts, PR
AF Hao, Yi-Heng
Fountain, Michael D., Jr.
Tacer, Klementina Fon
Xia, Fan
Bi, Weimin
Kang, Sung-Hae L.
Patel, Ankita
Rosenfeld, Jill A.
Le Caignec, Cedric
Isidor, Bertrand
Krantz, Ian D.
Noon, Sarah E.
Pfotenhauer, Jean P.
Morgan, Thomas M.
Moran, Rocio
Pedersen, Robert C.
Saenz, Margarita S.
Schaaf, Christian P.
Potts, Patrick Ryan
TI USP7 Acts as a Molecular Rheostat to Promote WASH-Dependent Endosomal
Protein Recycling and Is Mutated in a Human Neurodevelopmental Disorder
SO MOLECULAR CELL
LA English
DT Article
ID PRADER-WILLI-SYNDROME; E3 UBIQUITIN LIGASES; DEUBIQUITINATING ENZYMES;
CANDIDATE GENE; MAGEL2 GENE; P53; COMPLEX; HAUSP; INACTIVATION;
TRAFFICKING
AB Endosomal protein recycling is a fundamental cellular process important for cellular homeostasis, signaling, and fate determination that is implicated in several diseases. WASH is an actin-nucleating protein essential for this process, and its activity is controlled through K63-linked ubiquitination by the MAGE-L2-TRIM27 ubiquitin ligase. Here, we show that the USP7 deubiquitinating enzyme is an integral component of the MAGE-L2-TRIM27 ligase and is essential for WASH-mediated endosomal actin assembly and protein recycling. Mechanistically, USP7 acts as a molecular rheostat to precisely fine-tune endosomal F-actin levels by counteracting TRIM27 auto-ubiquitination/degradation and preventing overactivation of WASH through directly deubiquitinating it. Importantly, we identify de novo heterozygous loss-of-function mutations of USP7 in individuals with a neurodevelopmental disorder, featuring intellectual disability and autism spectrum disorder. These results provide unanticipated insights into endosomal trafficking, illuminate the cooperativity between an ubiquitin ligase and a deubiquitinating enzyme, and establish a role for USP7 in human neurodevelopmental disease.
C1 [Hao, Yi-Heng; Tacer, Klementina Fon; Potts, Patrick Ryan] Univ Texas SW Med Ctr Dallas, Dept Physiol, Dallas, TX 75390 USA.
[Hao, Yi-Heng; Tacer, Klementina Fon; Potts, Patrick Ryan] Univ Texas SW Med Ctr Dallas, Dept Pharmacol, Dallas, TX 75390 USA.
[Hao, Yi-Heng; Tacer, Klementina Fon; Potts, Patrick Ryan] Univ Texas SW Med Ctr Dallas, Dept Biochem, Dallas, TX 75390 USA.
[Fountain, Michael D., Jr.; Schaaf, Christian P.] Baylor Coll Med, Translat Biol & Mol Med, Houston, TX 77030 USA.
[Fountain, Michael D., Jr.; Xia, Fan; Bi, Weimin; Kang, Sung-Hae L.; Patel, Ankita; Schaaf, Christian P.] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA.
[Fountain, Michael D., Jr.; Schaaf, Christian P.] Texas Childrens Hosp, Jan & Dan Duncan Neurol Res Inst, Houston, TX 77030 USA.
[Le Caignec, Cedric; Isidor, Bertrand] CHU Nantes, Serv Genet Med, F-44093 Nantes, France.
[Krantz, Ian D.; Noon, Sarah E.] Childrens Hosp Philadelphia, Div Human Genet, Philadelphia, PA 19104 USA.
[Krantz, Ian D.] Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA.
[Pfotenhauer, Jean P.; Morgan, Thomas M.] Vanderbilt Univ, Sch Med, Div Med Genet & Genom Med, Nashville, TN 37232 USA.
[Moran, Rocio] Cleveland Clin, Genom Med Inst, Cleveland, OH 44195 USA.
[Pedersen, Robert C.] Tripler Army Med Ctr, Dept Pediat, Honolulu, HI 96859 USA.
[Saenz, Margarita S.] Childrens Hosp Colorado, Clin Genet & Metab, Aurora, CO 80045 USA.
[Rosenfeld, Jill A.] Signature Genom, Spokane, WA 99207 USA.
RP Schaaf, CP (reprint author), Baylor Coll Med, Translat Biol & Mol Med, Houston, TX 77030 USA.
EM schaaf@bcm.edu; ryan.potts@utsouthwestern.edu
FU Michael L. Rosenberg Scholar in Medical Research fund; CPRIT [R1117];
WELCH Foundation [I-1821]; NIH [R01GM111332]; Joan and Stanford
Alexander Family; Foundation for Prader-Willi Research; IDDRC from
Eunice Kennedy Shriver National Institute of Child Health & Human
Development [1U54 HD083092]; Wellcome Trust
FX We thank members of the P.R.P. lab, Michael Rosen, Daniel Billadeau, and
Ezra Burstein for helpful discussions and critical reading of the
manuscript. We also thank Pamela Mellon and Bert Vogelstein for critical
reagents, Genevera I. Allen for statistical support and discussion, and
Pawel Stankiewicz for his invaluable contributions on patient data. This
work was supported by Michael L. Rosenberg Scholar in Medical Research
fund (to P.R.P.), CPRIT R1117 (to P.R.P.), WELCH Foundation I-1821 (to
P.R.P.), NIH R01GM111332 (to P.R.P.), the Joan and Stanford Alexander
Family (to C.P.S.), and the Foundation for Prader-Willi Research (to
C.P.S. and P.R.P.). The project was supported in part by IDDRC grant
number 1U54 HD083092 from the Eunice Kennedy Shriver National Institute
of Child Health & Human Development. Cores: Translational Core.; We are
indebted to the patients and their families for their willingness to
participate in our study. This study makes use of data generated by the
DECIPHER Consortium. A full list of centers that contributed to the
generation of the data is available from http://decipher.sanger.ac.uk
and via email from decipher@sanger.ac.uk. Funding for the project was
provided by the Wellcome Trust. Those who carried out the original
analysis and collection of the data for DECIPHER bear no responsibility
for the further analysis or interpretation of it by our group or the
registered users of DECIPHER.
NR 40
TC 7
Z9 7
U1 2
U2 8
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 1097-2765
EI 1097-4164
J9 MOL CELL
JI Mol. Cell
PD SEP 17
PY 2015
VL 59
IS 6
BP 956
EP 969
DI 10.1016/j.molcel.2015.07.033
PG 14
WC Biochemistry & Molecular Biology; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA CW7GQ
UT WOS:000365166500009
ER
PT J
AU Elder, RM
Andzelm, JW
Sirk, TW
AF Elder, Robert M.
Andzelm, Jan W.
Sirk, Timothy W.
TI A molecular simulation study of the glass transition of cross-linked
poly(dicyclopentadiene) networks
SO CHEMICAL PHYSICS LETTERS
LA English
DT Article
ID MECHANICAL-PROPERTIES; EPOXY-RESINS; EFFICIENT GENERATION; AM1-BCC
MODEL; FORCE-FIELD; DICYCLOPENTADIENE; DYNAMICS; KINETICS;
POLYMERIZATION; BEHAVIOR
AB Cross-linked polymer networks are widely used as structural and protective materials, which require strength and toughness. Experiments have shown that cross-linked poly(dicyclopentadiene) (pDCPD) networks provide similar strength but superior fracture toughness relative to commonly-used network chemistries like epoxy. To better understand pDCPD, we use atomistic molecular dynamics to study the properties of pDCPD networks across the glass transition as a function of molecular weight between crosslinks. Moreover, we identify molecular mechanisms that potentially control mechanical and transport properties. The alpha-relaxation (the glass transition) is linked to intra-chain motions and large-scale segmental motions, while sub-T-g relaxations are linked with more localized motions. (C) 2015 Published by Elsevier B.V.
C1 [Elder, Robert M.; Andzelm, Jan W.; Sirk, Timothy W.] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RP Sirk, TW (reprint author), US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA.
EM timothy.w.sirk.civ@mail.mil
RI Elder, Robert/H-9886-2016
FU U.S. Department of Energy; USARL; DOD High Performance Computing
Modernization Program at the U.S. Air Force Research Laboratory; U.S.
Army Engineer Research and Development Center DoD Supercomputing
Resource Centers
FX RME was supported by an appointment to the Postgraduate Research
Participation Program at the U.S. Army Research Laboratory administered
by the Oak Ridge Institute for Science and Education through an
interagency agreement between the U.S. Department of Energy and USARL.
This work was supported by grants of computer time from the DOD High
Performance Computing Modernization Program at the U.S. Air Force
Research Laboratory and U.S. Army Engineer Research and Development
Center DoD Supercomputing Resource Centers. The authors thank Dr. Kevin
Masser (USARL) and Dr. Daniel Knorr (USARL) for useful discussions.
NR 47
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Z9 2
U1 6
U2 23
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0009-2614
EI 1873-4448
J9 CHEM PHYS LETT
JI Chem. Phys. Lett.
PD SEP 16
PY 2015
VL 637
BP 103
EP 109
DI 10.1016/j.cplett.2015.07.058
PG 7
WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical
SC Chemistry; Physics
GA CR9CG
UT WOS:000361650200020
ER
PT J
AU Yang, LY
Ho, J
Allahyarov, E
Mu, R
Zhu, L
AF Yang, Lianyun
Ho, Janet
Allahyarov, Elshad
Mu, Richard
Zhu, Lei
TI Semicrystalline Structure Dielectric Property Relationship and
Electrical Conduction in a Biaxially Oriented Poly(vinylidene fluoride)
Film under High Electric Fields and High Temperatures
SO ACS APPLIED MATERIALS & INTERFACES
LA English
DT Article
DE poly(vinylidene fluoride); dielectric constant; electronic conduction;
thermally stimulated depolarization current; space charge injection;
ionic polarization
ID HIGH-ENERGY DENSITY; FERROELECTRIC POLYMERS; POLY(METHYL METHACRYLATE);
POLYVINYLIDENE FLUORIDE; CRYSTALLIZATION; DYNAMICS; BEHAVIOR; PHASE;
RELAXATION; CAPACITORS
AB Poly(vinylidene fluoride) (PVDF)-based homopolymers and copolymers are attractive for a broad range of electroactive applications because of their high dielectric constants. Especially, biaxially oriented PVDF (BOPVDF) films exhibit a DC breakdown strength as high as that for biaxially oriented polypropylene films. In this work, we revealed the molecular origin of the high dielectric constant via study of a commercial BOPVDF film. By determination of the dielectric constant for the amorphous phase in BOPVDF, a high value of ca. 21-22 at 25 degrees C was obtained, and a three-phase (i.e., lamellar crystal/oriented interphase/amorphous region) semicrystalline model was proposed to explain this result. Meanwhile, electronic conduction mechanisms in BOPVDF under high electric fields and elevated temperatures were investigated by thermally stimulated depolarization current (TSDC) spectroscopy and leakage current studies. Space charge injection from metal electrodes was identified as a major factor for electronic conduction when BOPVDF was poled above 75 degrees C and 20 MV/m. In addition, when silver or aluminum were used as electrodes, new ions were generated from electrochemical reactions under high fields. Due to the electrochemical reactions between PVDF and the metal electrode, a question is raised for practical electrical applications using PVDF and its copolymers under high-field and high-temperature conditions. A potential method to prevent electrochemical degradation of PVDF is proposed in this study.
C1 [Yang, Lianyun; Allahyarov, Elshad; Zhu, Lei] Case Western Reserve Univ, Dept Macromol Sci & Engn, Cleveland, OH 44106 USA.
[Ho, Janet] RDRL SED C, Army Res Lab, Adelphi, MD 20783 USA.
[Allahyarov, Elshad] Russian Acad Sci, Joint Inst High Temp, Dept Theoret, Moscow 117419, Russia.
[Allahyarov, Elshad] Univ Dusseldorf, Inst Theoret Phys, D-40225 Dusseldorf, Germany.
[Mu, Richard] Fisk Univ, Dept Phys & Life Sci, Nashville, TN 37208 USA.
RP Zhu, L (reprint author), Case Western Reserve Univ, Dept Macromol Sci & Engn, Cleveland, OH 44106 USA.
EM lxz121@case.edu
RI Zhu, Lei/C-8754-2013; Yang, Lianyun/D-9917-2017
OI Zhu, Lei/0000-0001-6570-9123; Yang, Lianyun/0000-0001-9384-1324
FU Army Research Office (ARO) [W911NF-13-1-0153]; Defense University
Research Instrumentation Program (DURIP) [N00014-1-1-0805]
FX This work was supported by Army Research Office (ARO) under award number
W911NF-13-1-0153. The Novocontrol Concept 80 dielectric spectrometer was
purchased under an award from the Defense University Research
Instrumentation Program (DURIP), N00014-1-1-0805. The authors
acknowledge Dr. Maya Endoh and Professor Tadanori Koga at University of
Stony Brook for assistance with the synchrotron WAX]) experiments. The
synchrotron X-ray experiments were carried out at the National
Synchrotron Light Source, Brookhaven National Laboratory, supported by
the U.S. Department of Energy. Finally, the authors would thank
Professor Peter Frubing at University of Potsdam, Germany, for helpful
discussion on detailed TSDC measurements.
NR 56
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PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1944-8244
J9 ACS APPL MATER INTER
JI ACS Appl. Mater. Interfaces
PD SEP 16
PY 2015
VL 7
IS 36
BP 19894
EP 19905
DI 10.1021/acsami.5b02944
PG 12
WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary
SC Science & Technology - Other Topics; Materials Science
GA CR7BA
UT WOS:000361501700006
PM 26120953
ER
PT J
AU Fischel, MHH
Fischel, JS
Lafferty, BJ
Sparks, DL
AF Fischel, Matthew H. H.
Fischel, Jason S.
Lafferty, Brandon J.
Sparks, Donald L.
TI The influence of environmental conditions on kinetics of arsenite
oxidation by manganese-oxides
SO GEOCHEMICAL TRANSACTIONS
LA English
DT Article
DE Manganese-oxide; Arsenic; Kinetics; Redox; Biogenic manganese-oxides
ID MARINE BACILLUS SP.; NA-RICH BIRNESSITE; HEXAGONAL-BIRNESSITE;
ARSENIC(III) OXIDATION; SYNTHETIC BIRNESSITE; MN(II) OXIDATION; STRAIN
SG-1; MN OXIDES; SPECTROSCOPY; ADSORPTION
AB Background: Manganese-oxides are one of the most important minerals in soil due to their widespread distribution and high reactivity. Despite their invaluable role in cycling many redox sensitive elements, numerous unknowns remain about the reactivity of different manganese-oxide minerals under varying conditions in natural systems. By altering temperature, pH, and concentration of arsenite we were able to determine how manganese-oxide reactivity changes with simulated environmental conditions. The interaction between manganese-oxides and arsenic is particularly important because manganese can oxidize mobile and toxic arsenite into more easily sorbed and less toxic arsenate. This redox reaction is essential in understanding how to address the global issue of arsenic contamination in drinking water.
Results: The reactivity of manganese-oxides in ascending order is random stacked birnessite, hexagonal birnessite, biogenic manganese-oxide, acid birnessite, and d-MnO2. Increasing temperature raised the rate of oxidation. pH had a variable effect on the production of arsenate and mainly impacted the sorption of arsenate on d-MnO2, which decreased with increasing pH. Acid birnessite oxidized the most arsenic at alkaline and acidic pHs, with decreased reactivity towards neutral pH. The d-MnO2 showed a decline in reactivity with increasing arsenite concentration, while the acid birnessite had greater oxidation capacity under higher concentrations of arsenite. The batch reactions used in this study quantify the impact of environmental variances on different manganese-oxides' reactivity and provide insight to their roles in governing chemical cycles in the Critical Zone.
Conclusions: The reactivity of manganese-oxides investigated was closely linked to each mineral's crystallinity, surface area, and presence of vacancy sites. d-MnO2 and acid birnessite are thought to be synthetic representatives of naturally occurring biogenic manganese-oxides; however, the biogenic manganese-oxide exhibited a lag time in oxidation compared to these two minerals. Reactivity was clearly linked to temperature, which provides important information on how these minerals react in the subsurface environment. The pH affected oxidation rate, which is essential in understanding how manganese-oxides react differently in the environment and their potential role in remediating contaminated areas. Moreover, the contrasting oxidative capacity of seemingly similar manganese-oxides under varying arsenite concentrations reinforces the importance of each manganese-oxide mineral's unique properties.
C1 [Fischel, Matthew H. H.; Fischel, Jason S.; Sparks, Donald L.] Univ Delaware, Dept Plant & Soil Sci, Delaware Environm Inst, Newark, DE 19711 USA.
[Lafferty, Brandon J.] US Army, Corps Engineers, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
RP Fischel, MHH (reprint author), Univ Delaware, Dept Plant & Soil Sci, Delaware Environm Inst, 221 Acad St,250A ISE Lab, Newark, DE 19711 USA.
EM Fischel@udel.edu
FU National Science Foundation [EPS-0814251]; State of Delaware
FX The authors thank Caroline Golt and Gerald Hendricks for laboratory
assistance. We also extend our gratitude to the three reviewers for
their critical critique of the paper and suggestions. MHHF and JSF thank
Mike Zhu (University of Wyoming) for teaching essential skills required
to culture Pseudomonas putida strain GB-1 and form biogenic
manganese-oxide. Support for this manuscript was provided by Delaware
EPSCoR with funds from the National Science Foundation Grant EPS-0814251
and the State of Delaware.
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PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1467-4866
J9 GEOCHEM T
JI Geochem. Trans.
PD SEP 16
PY 2015
VL 16
AR 15
DI 10.1186/s12932-015-0030-4
PG 10
WC Geochemistry & Geophysics
SC Geochemistry & Geophysics
GA CR4CQ
UT WOS:000361279800001
PM 26388696
ER
PT J
AU Rickards, CA
Johnson, BD
Harvey, RE
Convertino, VA
Joyner, MJ
Barnes, JN
AF Rickards, Caroline A.
Johnson, Blair D.
Harvey, Ronee E.
Convertino, Victor A.
Joyner, Michael J.
Barnes, Jill N.
TI Cerebral blood velocity regulation during progressive blood loss
compared with lower body negative pressure in humans
SO JOURNAL OF APPLIED PHYSIOLOGY
LA English
DT Article
DE simulated hemorrhage; cerebrovascular; hypovolemia
ID ORTHOSTATIC STRESS; FLOW VELOCITY; CENTRAL HYPOVOLEMIA;
CARDIOVASCULAR-RESPONSES; HEMODYNAMIC-RESPONSES; TRANSCRANIAL DOPPLER;
ARTERIAL-PRESSURE; CARDIAC-OUTPUT; HEMORRHAGE; AUTOREGULATION
AB Lower body negative pressure (LBNP) is often used to simulate blood loss in humans. It is unknown if cerebral blood flow responses to actual blood loss are analogous to simulated blood loss during LBNP. Nine healthy men were studied at baseline, during three levels of LBNP (5 min at - 15, - 30, and - 45 mmHg), and during three levels of blood loss (333, 667, and 1,000 ml). LBNP and blood loss conditions were randomized. Intra-arterial mean arterial pressure (MAP) during LBNP was similar to that during blood loss (P >= 0.42). Central venous pressure (2.8 +/- 0.7 vs. 4.0 +/- 0.8, 1.2 +/- 0.6 vs. 3.5 +/- 0.8, and 0.2 +/- 0.9 vs. 2.1 +/- 0.9 mmHg for levels 1, 2, and 3, respectively, P <= 0.003) and stroke volume (71 +/- 4 vs. 80 +/- 3, 60 +/- 3 vs. 74 +/- 3, and 51 +/- 2 vs. 68 +/- 4 ml for levels 1, 2, and 3, respectively, P <= 0.002) were lower during LBNP than blood loss. Despite differences in central venous pressure, middle cerebral artery velocity (MCAv) and cerebrovascular conductance were similar between LBNP and blood loss at each level (MCAv at level 3: 62 +/- 6 vs. 66 +/- 5 cm/ s, P = 0.37; cerebrovascular conductance at level 3: 0.72 +/- 0.05 vs. 0.73 +/- 0.05 cm.s(-1).mmHg(-1), P = 0.53). While the slope of the MAP-MCAv relationship was slightly different between LBNP and blood loss (0.41 +/- 0.03 and 0.66 +/- 0.04 cm.s(-1).mmHg(-1), respectively, P = 0.05), time domain gain between MAP and MCAv at maximal LBNP/blood loss (P = 0.23) and low-frequency MAP-mean MCAv transfer function coherence, gain, and phase were similar (P >= 0.10). Our results suggest that cerebral hemodynamic responses to LBNP to - 45 mmHg and blood loss up to 1,000 ml follow a similar trajectory, and the arterial pressure-cerebral blood velocity relationship is not altered from baseline under these conditions.
C1 [Rickards, Caroline A.] Univ N Texas, Hlth Sci Ctr, Dept Integrat Physiol & Anat, Ft Worth, TX 76107 USA.
[Rickards, Caroline A.] Univ N Texas, Hlth Sci Ctr, Cardiovasc Res Inst, Ft Worth, TX 76107 USA.
[Johnson, Blair D.; Harvey, Ronee E.; Joyner, Michael J.; Barnes, Jill N.] Mayo Clin, Dept Anesthesiol, Rochester, MN USA.
[Convertino, Victor A.] US Army Inst Surg Res, Ft Sam Houston, TX USA.
[Barnes, Jill N.] Mayo Clin, Dept Physiol & Biomed Engn, Rochester, MN USA.
RP Rickards, CA (reprint author), Univ N Texas, Hlth Sci Ctr, Dept Integrat Physiol & Anat, 3500 Camp Bowie Blvd, Ft Worth, TX 76107 USA.
EM caroline.rickards@unthsc.edu
FU US Army Medical Research and Materiel Command Combat Casualty Care
Research Program [W81XWH-11-1-0823, W81XWH-11-2-0137]; National
Institute on Aging [AG-038067]; American Heart Association Midwest
Affiliate Grants [13POST-14380027, 14PRE-18040000]; National Center for
Advancing Translational Sciences Clinical and Translational Science
Award [UL1 TR-000135]
FX This work was funded by US Army Medical Research and Materiel Command
Combat Casualty Care Research Program Grants W81XWH-11-1-0823 (M. J.
Joyner) and W81XWH-11-2-0137 (C. A. Rickards), National Institute on
Aging Grant AG-038067 (J. N. Barnes), and American Heart Association
Midwest Affiliate Grants 13POST-14380027 (B. D. Johnson) and
14PRE-18040000 (R. E. Harvey). This publication was made possible by
National Center for Advancing Translational Sciences Clinical and
Translational Science Award UL1 TR-000135 and the US Army.
NR 55
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U2 5
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 8750-7587
EI 1522-1601
J9 J APPL PHYSIOL
JI J. Appl. Physiol.
PD SEP 15
PY 2015
VL 119
IS 6
BP 677
EP 685
DI 10.1152/japplphysiol.00127.2015
PG 9
WC Physiology; Sport Sciences
SC Physiology; Sport Sciences
GA CR6SG
UT WOS:000361477000010
PM 26139213
ER
PT J
AU Corona, BT
Green, MS
AF Corona, Benjamin T.
Green, Michael S.
TI "CAN ELITE ATHLETES BENEFIT FROM DIETARY NITRATE SUPPLEMENTATION?":
GREATER ERGOGENIC OPPORTUNITY IN THE MASTER ATHLETE?
SO JOURNAL OF APPLIED PHYSIOLOGY
LA English
DT Letter
ID PERFORMANCE
C1 [Corona, Benjamin T.] US Army, Inst Surg Res, Extrem Trauma & Regenerat Med, Ft Sam Houston, TX 78234 USA.
[Green, Michael S.] Troy Univ, Dept Kinesiol & Hlth Promot, Troy, AL USA.
RP Corona, BT (reprint author), US Army, Inst Surg Res, Extrem Trauma & Regenerat Med, Ft Sam Houston, TX 78234 USA.
NR 5
TC 0
Z9 0
U1 2
U2 5
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 8750-7587
EI 1522-1601
J9 J APPL PHYSIOL
JI J. Appl. Physiol.
PD SEP 15
PY 2015
VL 119
IS 6
BP 765
EP 766
PG 2
WC Physiology; Sport Sciences
SC Physiology; Sport Sciences
GA CR6SG
UT WOS:000361477000030
ER
PT J
AU Kajon, AE
Hang, J
Hawksworth, A
Metzgar, D
Hage, E
Hansen, CJ
Kuschner, RA
Blair, P
Russell, KL
Jarman, RG
AF Kajon, Adriana E.
Hang, Jun
Hawksworth, Anthony
Metzgar, David
Hage, Elias
Hansen, Christian J.
Kuschner, Robert A.
Blair, Patrick
Russell, Kevin L.
Jarman, Richard G.
TI Molecular Epidemiology of Adenovirus Type 21 Respiratory Strains
Isolated From US Military Trainees (1996-2014)
SO JOURNAL OF INFECTIOUS DISEASES
LA English
DT Article
DE adenovirus evolution; DNA; military; molecular epidemiology
ID HYPERVARIABLE REGIONS; ENTERIC IMMUNIZATION; YOUNG-CHILDREN; INFECTION;
RECRUITS; DISEASE; ILLNESS; OUTBREAK; VACCINES; LIVE
AB Background. The circulation of human adenovirus type 21 (HAdV21) in the United States has been documented since the 1960s in association with outbreaks of febrile respiratory illness (FRI) in military boot camps and civilian cases of respiratory disease.
Methods.aEuro integral To describe the molecular epidemiology of HAdV21 respiratory infections across the country, 150 clinical respiratory isolates obtained from continuous surveillance of military recruit FRI, and 23 respiratory isolates recovered from pediatric and adult civilian cases of acute respiratory infection were characterized to compile molecular typing data spanning 37 years (1978-2014).
Results.aEuro integral Restriction enzyme analysis and genomic sequencing identified 2 clusters of closely related genomic variants readily distinguishable from the prototype and designated 21a-like and 21b-like. A-like variants predominated until 1999. A shift to b-like variants was noticeable by 2007 after a 7-year period (2000-2006) of cocirculation of the 2 genome types. US strains are phylogenetically more closely related to European and Asian strains isolated over the last 4 decades than to the Saudi Arabian prototype strain AV-1645 isolated in 1956.
Conclusions.aEuro integral Knowledge of circulating HAdV21 variants and their epidemic behavior will be of significant value to local and global FRI surveillance efforts.
C1 [Kajon, Adriana E.] Lovelace Resp Res Inst, Albuquerque, NM 87108 USA.
[Hang, Jun; Kuschner, Robert A.; Jarman, Richard G.] Walter Reed Army Inst Res, Viral Dis Branch, Silver Spring, MD USA.
[Hawksworth, Anthony; Metzgar, David; Hansen, Christian J.; Blair, Patrick] Naval Hlth Res Ctr, Operat Infect Dis Dept, San Diego, CA USA.
[Hage, Elias] Hannover Med Sch, Inst Virol, Hannover, Germany.
[Russell, Kevin L.] Armed Forces Hlth Surveillance Ctr, Silver Spring, MD USA.
RP Kajon, AE (reprint author), Lovelace Resp Res Inst, Program Infect Dis, 2425 Ridgecrest Dr SE, Albuquerque, NM 87108 USA.
EM akajon@lrri.org
FU Department of Defense Global Emerging Infections Surveillance and
Response System, a division of the Armed Forces Health Surveillance
Center [C0409-11, C0605-12, P0023-13, P0023-14]; Department of Defense
Global Emerging Infections Surveillance and Response System, a division
of the Armed Forces Health Surveillance Center (Naval Health Research
Center Work Unit) [60805]
FX This work was supported by the Department of Defense Global Emerging
Infections Surveillance and Response System, a division of the Armed
Forces Health Surveillance Center (grant numbers C0409-11, C0605-12,
P0023-13 and P0023-14, and Naval Health Research Center Work Unit No.
60805).
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PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0022-1899
EI 1537-6613
J9 J INFECT DIS
JI J. Infect. Dis.
PD SEP 15
PY 2015
VL 212
IS 6
BP 871
EP 880
DI 10.1093/infdis/jiv141
PG 10
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA CR4EW
UT WOS:000361285600005
PM 25748322
ER
PT J
AU Vejbaesya, S
Thongpradit, R
Kalayanarooj, S
Luangtrakool, K
Luangtrakool, P
Gibbons, RV
Srinak, D
Ngammthaworn, S
Apisawes, K
Yoon, IK
Thomas, SJ
Jarman, RG
Srikiakthachorn, A
Green, S
Chandanayingyong, D
Park, S
Friedman, J
Rothman, AL
Stephens, HAF
AF Vejbaesya, Sasijit
Thongpradit, Rungrot
Kalayanarooj, Siripen
Luangtrakool, Komon
Luangtrakool, Panpimon
Gibbons, Robert V.
Srinak, Duangporn
Ngammthaworn, Somporn
Apisawes, Kusuma
Yoon, In-Kyu
Thomas, Stephen J.
Jarman, Richard G.
Srikiakthachorn, Anon
Green, Sharone
Chandanayingyong, Dasnayanee
Park, Sangshin
Friedman, Jennifer
Rothman, Alan L.
Stephens, Henry A. F.
TI HLA Class I Supertype Associations With Clinical Outcome of Secondary
Dengue Virus Infections in Ethnic Thais
SO JOURNAL OF INFECTIOUS DISEASES
LA English
DT Article
DE HLA; class I; B44; supertype; associations; secondary; dengue;
infections; Thais
ID HEMORRHAGIC-FEVER; DISEASE SEVERITY; MOLECULES; SEROTYPE; ALLELE;
POPULATIONS; HAPLOTYPES; RESPONSES; CORRELATE; EPITOPE
AB Background. Human leukocyte antigen (HLA) supertypes are groups of functionally related alleles that present structurally similar antigens to the immune system.
Objectives.aEuro integral To analyze HLA class I supertype associations with clinical outcome in hospitalized Thai children with acute dengue illness.
Methods.aEuro integral Seven hundred sixty-two patients and population-matched controls recruited predominantly in Bangkok were HLA-A and -B typed. HLA supertype frequencies were compared and tested for significant dengue disease associations using logistic regression analyses. Multivariable models were built by conducting forward stepwise selection procedures.
Results.aEuro integral In the final logistic regression model, the HLA-B44 supertype was protective against dengue hemorrhagic fever (DHF) in secondary infections (odds ratio [OR] = 0.46, 95% confidence interval [CI], .30-.72), while the HLA-A02 supertype (OR = 1.92, 95% CI, 1.30-2.83) and the HLA-A01/03 supertype (OR = 3.01, 95% CI, 1.01-8.92) were associated with susceptibility to secondary dengue fever. The B07 supertype was associated with susceptibility to secondary DHF in the univariate analysis (OR = 1.60, 95% CI, 1.05-2.46), whereas that was not retained in the final model.
Conclusions.aEuro integral As the HLA-B44 supertype is predicted to target conserved epitopes in dengue, our results suggest that B44 supertype-restricted immune responses to highly conserved regions of the dengue proteome may protect against secondary DHF.
C1 [Vejbaesya, Sasijit; Thongpradit, Rungrot; Luangtrakool, Komon; Luangtrakool, Panpimon; Srinak, Duangporn; Ngammthaworn, Somporn; Apisawes, Kusuma; Chandanayingyong, Dasnayanee; Stephens, Henry A. F.] Mahidol Univ, Siriraj Hosp, Fac Med, Dept Transfus Med, Bangkok 10700, Thailand.
[Kalayanarooj, Siripen] Queen Sirikit Natl Inst Child Hlth, Bangkok, Thailand.
[Gibbons, Robert V.; Yoon, In-Kyu] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand.
[Thomas, Stephen J.; Jarman, Richard G.] Walter Reed Army Inst Res, Viral Dis Branch, Silver Spring, MD USA.
[Srikiakthachorn, Anon; Green, Sharone] Univ Massachusetts, Sch Med, Dept Med, Div Infect Dis & Immunol, Worcester, MA 01605 USA.
[Park, Sangshin; Friedman, Jennifer] Brown Univ, Warren Alpert Med Sch, Rhode Isl Hosp, Ctr Int Hlth Res, Providence, RI 02912 USA.
[Rothman, Alan L.] Univ Rhode Isl, Inst Immunol & Informat, Providence, RI 02908 USA.
[Stephens, Henry A. F.] UCL, Ctr Nephrol, London NW3 2PF, England.
[Stephens, Henry A. F.] Royal Free Hosp, Royal Free NHS Fdn Trust, Anthony Nolan Labs, London NW3 2QG, England.
RP Stephens, HAF (reprint author), UCL, Ctr Nephrol & Anthony Nolan Trust, Royal Free Hosp Campus,Rowland Hill St, London NW3 2PF, England.
EM h.stephens@ucl.ac.uk
OI Friedman, Jennifer/0000-0001-5804-9921; Park,
Sangshin/0000-0003-2407-0962
FU National Institutes of Health USA [NIH-P01AI34533]; US Army Medical
Research and Materiel Command
FX This work was supported by a Program Project grant from the National
Institutes of Health USA (NIH-P01AI34533) and the US Army Medical
Research and Materiel Command. This study was granted human use approval
by the Institutional Review Boards of the Thai Ministry of Public
Health, the Office of the US Army Surgeon General's Office, and the
University of Massachusetts Medical School.
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PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0022-1899
EI 1537-6613
J9 J INFECT DIS
JI J. Infect. Dis.
PD SEP 15
PY 2015
VL 212
IS 6
BP 939
EP 947
DI 10.1093/infdis/jiv127
PG 9
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA CR4EW
UT WOS:000361285600014
PM 25740956
ER
PT J
AU Lin, JT
Hathaway, NJ
Saunders, DL
Lon, C
Balasubramanian, S
Kharabora, O
Gosi, P
Sriwichai, S
Kartchner, L
Chuor, CM
Satharath, P
Lanteri, C
Bailey, JA
Juliano, JJ
AF Lin, Jessica T.
Hathaway, Nicholas J.
Saunders, David L.
Lon, Chanthap
Balasubramanian, Sujata
Kharabora, Oksana
Gosi, Panita
Sriwichai, Sabaithip
Kartchner, Laurel
Chuor, Char Meng
Satharath, Prom
Lanteri, Charlotte
Bailey, Jeffrey A.
Juliano, Jonathan J.
TI Using Amplicon Deep Sequencing to Detect Genetic Signatures of
Plasmodium vivax Relapse
SO JOURNAL OF INFECTIOUS DISEASES
LA English
DT Article
DE amplicon sequencing; deep sequencing; genetic diversity; hypnozoite;
malaria; microsatellite; multiplicity of infection; Plasmodium vivax;
pvmsp1; relapse
ID HETERODUPLEX TRACKING ASSAY; HUMAN MALARIA PARASITE; FALCIPARUM
INFECTIONS; DIVERSITY; ELIMINATION; HYPNOZOITES; RESISTANCE; CAMBODIA;
COMPLEX; POLYMORPHISMS
AB Plasmodium vivax infections often recur due to relapse of hypnozoites from the liver. In malaria-endemic areas, tools to distinguish relapse from reinfection are needed. We applied amplicon deep sequencing to P. vivax isolates from 78 Cambodian volunteers, nearly one-third of whom suffered recurrence at a median of 68 days. Deep sequencing at a highly variable region of the P. vivax merozoite surface protein 1 gene revealed impressive diversity-generating 67 unique haplotypes and detecting on average 3.6 cocirculating parasite clones within individuals, compared to 2.1 clones detected by a combination of 3 microsatellite markers. This diversity enabled a scheme to classify over half of recurrences as probable relapses based on the low probability of reinfection by multiple recurring variants. In areas of high P. vivax diversity, targeted deep sequencing can help detect genetic signatures of relapse, key to evaluating antivivax interventions and achieving a better understanding of relapse-reinfection epidemiology.
C1 [Lin, Jessica T.; Balasubramanian, Sujata; Kharabora, Oksana; Juliano, Jonathan J.] Univ N Carolina, Sch Med, Div Infect Dis, Chapel Hill, NC 27599 USA.
[Hathaway, Nicholas J.; Bailey, Jeffrey A.] Univ Massachusetts, Program Bioinformat & Integrat Biol, Worcester, MA 01605 USA.
[Saunders, David L.; Lon, Chanthap; Gosi, Panita; Sriwichai, Sabaithip; Lanteri, Charlotte] Armed Forces Res Inst Med Sci, US Army Med Component, Bangkok 10400, Thailand.
[Kartchner, Laurel] Univ N Carolina, Dept Microbiol & Immunol, Chapel Hill, NC 27599 USA.
[Chuor, Char Meng] Natl Ctr Parasitol Entomol & Malaria Control, Phnom Penh, Cambodia.
[Satharath, Prom] Royal Cambodian Armed Forces, Phnom Penh, Cambodia.
[Bailey, Jeffrey A.] Univ Massachusetts, Sch Med, Div Transfus Med, Worcester, MA USA.
RP Lin, JT (reprint author), Univ N Carolina, Sch Med, Div Infect Dis, 130 Mason Farm Rd,Ste 2115 CB 7030, Chapel Hill, NC 27599 USA.
EM jessica_lin@med.unc.edu
FU National Institutes of Health [K08 AI110651, R01 AI089819, R01
AI099473-03]; US Army Medical Materiel Development Activity, Fort
Detrick, MD; American Society of Tropical Medicine and Hygiene
(ASTMH)/Burroughs Wellcome Postdoctoral Fellowship in Tropical
Infectious Disease
FX This work was supported by the National Institutes of Health (grants K08
AI110651 to J. T. L., R01 AI089819 to J. J. J., R01 AI099473-03 to J. A.
B.) and the US Army Medical Materiel Development Activity, Fort Detrick,
MD. J. T. L. was also supported by an American Society of Tropical
Medicine and Hygiene (ASTMH)/Burroughs Wellcome Postdoctoral Fellowship
in Tropical Infectious Disease.
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PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0022-1899
EI 1537-6613
J9 J INFECT DIS
JI J. Infect. Dis.
PD SEP 15
PY 2015
VL 212
IS 6
BP 999
EP 1008
DI 10.1093/infdis/jiv142
PG 10
WC Immunology; Infectious Diseases; Microbiology
SC Immunology; Infectious Diseases; Microbiology
GA CR4EW
UT WOS:000361285600020
PM 25748326
ER
PT J
AU Ingold, KA
Marandi, A
Digonnet, MJF
Byer, RL
AF Ingold, Kirk A.
Marandi, Alireza
Digonnet, Michel J. F.
Byer, Robert L.
TI Fiber-feedback optical parametric oscillator for half-harmonic
generation of sub-100-fs frequency combs around 2 mu m
SO OPTICS LETTERS
LA English
DT Article
ID PHASE; LASER; POWER; OPO
AB We demonstrate a femtosecond fiber-feedback optical parametric oscillator (OPO) at degeneracy. The OPO cavity comprises an 80-cm-long fiber composed of a combination of normal and anomalous dispersion sections that provide a net intracavity group delay dispersion close to zero. By using a mode-locked, Yb-doped fiber laser as the pump, we achieved half-harmonic generation of 250-MHz, 1.2-nJ nearly transform-limited 97-fs pulses centered at 2090 nm with a total conversion efficiency of 36%. (C) 2015 Optical Society of America
C1 [Ingold, Kirk A.; Marandi, Alireza; Digonnet, Michel J. F.; Byer, Robert L.] Stanford Univ, Edward L Ginzton Lab, Stanford, CA 94305 USA.
[Ingold, Kirk A.] US Mil Acad, Photon Res Ctr, West Point, NY 10996 USA.
RP Ingold, KA (reprint author), Stanford Univ, Edward L Ginzton Lab, Stanford, CA 94305 USA.
EM kirk.ingold@usma.edu
OI Marandi, Alireza/0000-0002-0470-0050
FU Joint Technologies Office
FX Joint Technologies Office.
NR 19
TC 2
Z9 2
U1 2
U2 10
PU OPTICAL SOC AMER
PI WASHINGTON
PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA
SN 0146-9592
EI 1539-4794
J9 OPT LETT
JI Opt. Lett.
PD SEP 15
PY 2015
VL 40
IS 18
BP 4368
EP 4371
DI 10.1364/OL.40.004368
PG 4
WC Optics
SC Optics
GA CR7UJ
UT WOS:000361556700046
PM 26371938
ER
PT J
AU Smith, CD
Wright, LKM
Garcia, GE
Lee, RB
Lumley, LA
AF Smith, Carl D.
Wright, Linnzi K. M.
Garcia, Gregory E.
Lee, Robyn B.
Lumley, Lucille A.
TI Hormone-dependence of sarin lethality in rats: Sex differences and stage
of the estrous cycle
SO TOXICOLOGY AND APPLIED PHARMACOLOGY
LA English
DT Article
DE Sarin; Nerve agents; Sex differences; Estrous cycle; LD50
ID AIRWAY SMOOTH-MUSCLE; ORGANOPHOSPHORUS COMPOUNDS;
CLINICAL-MANIFESTATIONS; CHOLINESTERASE ACTIVITY; EXPOSURE
CONCENTRATION; SOMAN; ANDROGENS; FEMALE; SERUM; VAPOR
AB Chemical warfare nerve agents (CWNAs) are highly toxic compounds that cause a cascade of symptoms and death, if exposed casualties are left untreated. Numerous rodent models have investigated the toxicity and mechanisms of toxicity of CWNAs, but most are limited to male subjects. Given the profound physiological effects of circulating gonadal hormones in female rodents, it is possible that the daily cyclical fluctuations of these hormones affect females' sensitivity to the lethal effects of CWNAs, and previous reports that included female subjects did not control for the stage of the hormonal cycle. The aim of the current study was to determine the 24-hour median lethal dose (LD50) of the CWNA sarin in male, ovariectomized (OVEX) female, and female rats during different stages of the estrous cycle (diestrus, proestrus, and estrus). Additionally, baseline activity levels of plasma acetylcholinesterase, butyrylcholinesterase, and carboxylesterase were measured to determine differences among the groups. Results indicated that females in proestrus had a significantly higher LD50 of sarin compared to OVEX and estrous females. Although some sex differences were observed in the activity levels of plasma esterases, they were not consistent and likely not large enough to significantly affect the LD(50)s. These results suggest that hormonal cyclicity can influence the outcome of CWNA-related studies using female rodents, and that this variability can be minimized by controlling for the stage of the cycle. Additional research is necessary to determine the precise mechanism of the observed differences because it is unlikely to be solely explained by plasma esterase activity. Published by Elsevier Inc.
C1 [Smith, Carl D.; Wright, Linnzi K. M.; Garcia, Gregory E.; Lee, Robyn B.; Lumley, Lucille A.] US Army Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA.
RP Smith, CD (reprint author), US Army Med Res Inst Chem Def, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 USA.
EM carl.d.smith179.mil@mail.mil
OI Smith, Carl/0000-0003-1332-7611
FU NIH CounterACT Administrative Supplement Program [U01NS058183-07S1]
FX This research was supported by the NIH CounterACT Administrative
Supplement Program #U01NS058183-07S1. The authors would like to thank
Curtis Bradley, Conor Jennings, Caroline Schultz, and Amanda Furman for
their assistance with animal handling, and Dr. Heidi Hoard-Fruchey, Dr.
Douglas Cerasoli, and Dr. Erik Johnson for their review of this paper.
NR 36
TC 3
Z9 3
U1 0
U2 40
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0041-008X
EI 1096-0333
J9 TOXICOL APPL PHARM
JI Toxicol. Appl. Pharmacol.
PD SEP 15
PY 2015
VL 287
IS 3
BP 253
EP 257
DI 10.1016/j.taap.2015.06.010
PG 5
WC Pharmacology & Pharmacy; Toxicology
SC Pharmacology & Pharmacy; Toxicology
GA CQ2IG
UT WOS:000360422800008
PM 26079828
ER
PT J
AU Wang, WY
Han, JJ
Fang, HZ
Wang, J
Liang, YF
Shang, SL
Wang, Y
Liu, XJ
Kecskes, LJ
Mathaudhu, SN
Hui, X
Liu, ZK
AF Wang, W. Y.
Han, J. J.
Fang, H. Z.
Wang, J.
Liang, Y. F.
Shang, S. L.
Wang, Y.
Liu, X. J.
Kecskes, L. J.
Mathaudhu, S. N.
Hui, X.
Liu, Z. K.
TI Anomalous structural dynamics in liquid Al80Cu20: An ab initio molecular
dynamics study
SO ACTA MATERIALIA
LA English
DT Article
DE Diffusivity; Viscosity; Fragility; Deformation electron density;
Structural relaxation
ID TOTAL-ENERGY CALCULATIONS; AUGMENTED-WAVE METHOD; MEDIUM-RANGE ORDER;
METALLIC GLASSES; SUPERCOOLED LIQUIDS; ATOMIC-STRUCTURE; BINARY-ALLOYS;
AL-CU; MECHANICAL-PROPERTIES; BASIS-SET
AB In this work, the structural dynamics of liquid Al80Cu20 is systematically investigated in terms of the evolution of its atomic structure, diffusivity, viscosity and fragility through ab initio molecular dynamics simulations. In addition to using pair correlation functions and coordination numbers, the various local ordered clusters are characterized comprehensively by Honeycutt-Anderson bond pairs and Voronoi polyhedra. Compared to the self diffusivity of pure liquid Cu, the tracer diffusion coefficients of Cu in liquid Al80Cu20 are increased, in agreement with the results measured by quasielastic neutron-scattering (QENS). Although the interdiffusion coefficients predicted by Darken's equation match well to those obtained from the viscosity measurements via the Stokes-Einstein relation, they are smaller than those measured by QENS or X-ray radiography, indicative of an anomalous nature of the structural dynamics, dominated by the local ordered clusters in liquid Al80Cu20. Furthermore, Vogel-Fulcher-Tammann fitting results indicate that the liquid Al80Cu20 can be classified into a strong liquid. The deformation electron density shows that the intrinsic tetrahedral-type bonds in FCC Al and Cu are transformed into an amorphous type in liquid Al80Cu20. The present work provides insights into the understanding of structural dynamics and the kinetic properties of such metallic melts. (C) 2015 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
C1 [Wang, W. Y.; Fang, H. Z.; Wang, J.; Liang, Y. F.; Shang, S. L.; Wang, Y.; Liu, Z. K.] Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA.
[Wang, W. Y.; Liang, Y. F.; Hui, X.] Univ Sci & Technol Beijing, State Key Lab Adv Met & Mat, Beijing 100083, Peoples R China.
[Wang, J.] Cent S Univ, State Key Lab Powder Met, Changsha 410083, Hunan, Peoples R China.
[Kecskes, L. J.] US Army Res Lab, Mat & Mfg Sci Div, Aberdeen Proving Ground, MD 21005 USA.
[Han, J. J.; Liu, X. J.] Xiamen Univ, Coll Mat, Dept Mat Sci & Engn, Xiamen 361005, Peoples R China.
[Mathaudhu, S. N.] Univ Calif Riverside, Dept Mech Engn, Riverside, CA 92521 USA.
RP Wang, WY (reprint author), Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA.
EM yuw129@psu.edu; xdhui@skl.ustb.edu.cn
RI Shang, Shun-Li/A-6564-2009; Wang, William Yi/F-8212-2011; Hui,
Xidong/A-1741-2010; Liang, Yongfeng/D-1459-2013; Wang, Yi/D-1032-2013;
Liu, Zi-Kui/A-8196-2009
OI Shang, Shun-Li/0000-0002-6524-8897; Wang, William
Yi/0000-0002-8814-525X; Liu, Zi-Kui/0000-0003-3346-3696
FU United States National Science Foundation [DMR-1006557]; U.S. Army
Research Laboratory [W911NF-08-2-0084]; National Key Basic Research
Program of China (973 Program) [2012CB825700]; National Natural Science
Foundation of China [50871013, 51271018]; American Academic Exchange
Service; China Scholarship Council [[2008]3072, [2009]3012]; Fundamental
Research Funds for Central Universities [20720150079]; Materials
Simulation Center; Institute for CyberScience; NSF [OCI-0821527,
ACI-1053575]
FX This work was financially supported by the United States National
Science Foundation (Grant DMR-1006557) and the U.S. Army Research
Laboratory (Project No. W911NF-08-2-0084), the National Key Basic
Research Program of China (973 Program, Project No. 2012CB825700) and
the National Natural Science Foundation of China (Grants 50871013 and
51271018). W.Y. Wang and J. Wang acknowledge the support from the
Project Based Personnel Exchange Program with the American Academic
Exchange Service and the China Scholarship Council ([2008]3072 and
[2009]3012). J.J. Han acknowledges the financial support from the
Fundamental Research Funds for the Central Universities (Grant No.
20720150079). First-principles calculations were carried out on the LION
clusters at the Pennsylvania State University supported by the Materials
Simulation Center and the Institute for CyberScience. Calculations were
also carried out on the CyberStar cluster funded by the NSF through
Grant No. OCI-0821527and the XSEDE clusters supported by NSF through
Grant ACI-1053575.
NR 95
TC 5
Z9 5
U1 17
U2 69
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 1359-6454
EI 1873-2453
J9 ACTA MATER
JI Acta Mater.
PD SEP 15
PY 2015
VL 97
BP 75
EP 85
DI 10.1016/j.actamat.2015.07.001
PG 11
WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical
Engineering
SC Materials Science; Metallurgy & Metallurgical Engineering
GA CP4TP
UT WOS:000359875800008
ER
PT J
AU McLeod, MV
Giri, AK
Paterson, BA
Dennis, CL
Zhou, L
Vogel, SC
Gourdon, O
Reiche, HM
Cho, KC
Sohn, YH
Shull, RD
Majumdar, BS
AF McLeod, M. V.
Giri, A. K.
Paterson, B. A.
Dennis, C. L.
Zhou, L.
Vogel, S. C.
Gourdon, O.
Reiche, H. M.
Cho, K. C.
Sohn, Y. H.
Shull, R. D.
Majumdar, B. S.
TI Magnetocaloric response of non-stoichiometric Ni2MnGa alloys and the
influence of crystallographic texture
SO ACTA MATERIALIA
LA English
DT Article
DE Magnetocaloric; NiMnGa alloy; Polycrystalline; Preferred orientation;
Twinning
ID MN-GA ALLOYS; FIELD-INDUCED STRAIN; SHAPE-MEMORY ALLOYS; ENTROPY CHANGE;
NITI; DEFORMATION; PHASE; DIFFRACTOMETER; TRANSFORMATION; TRANSITIONS
AB Currently, there is significant interest in magnetocaloric materials for solid state refrigeration. In this work, polycrystalline Heusler alloys belonging to the Ni2+xMn1-xGa family, with x between 0.08 and 0.24, were evaluated for the purpose of finding composition(s) with an enhanced magnetocaloric effect (MCE) close to room temperature. Differential scanning calorimetry (DSC) was successfully used to screen alloy composition for simultaneous magnetic and structural phase transformations; this coupling needed for a giant MCE. The alloy with x = 0.16 showed an excellent match of transformation temperatures and exhibited the highest magnetic entropy change, Delta S-M, in the as-annealed state. Furthermore, the MCE increased by up to 84% with a 2 Tesla (T) field change when the samples were thermally cycled through the martensite to austenite transformation temperature while held under a constant mechanical load. The highest Delta S-M measured for our x = 0.16 alloy for a 2 T magnetic field change was -18 J/kg K. Texture measurements suggest that preferential orientation of martensite variants contributed to the enhanced MCE in the stress-assisted thermally cycled state. (C) 2015 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
C1 [McLeod, M. V.; Majumdar, B. S.] New Mexico Inst Min & Technol, Socorro, NM 87801 USA.
[Giri, A. K.] TKC Global, Herndon, VA 20171 USA.
[Paterson, B. A.; Dennis, C. L.; Shull, R. D.] NIST, Gaithersburg, MD 20899 USA.
[Zhou, L.; Sohn, Y. H.] Univ Cent Florida, Orlando, FL 32816 USA.
[Vogel, S. C.; Gourdon, O.; Reiche, H. M.] Los Alamos Natl Lab, Lujan Neutron Sci Ctr, Los Alamos, NM 87545 USA.
[Cho, K. C.] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RP Majumdar, BS (reprint author), New Mexico Inst Min & Technol, Socorro, NM 87801 USA.
EM majumdar@nmt.edu
RI Sohn, Yongho/A-8517-2010; Zhou, Le/H-9531-2016
OI Sohn, Yongho/0000-0003-3723-4743; Zhou, Le/0000-0001-8327-6667
FU Director's Research Initiative at the US Army Research Laboratories
[W911NF-11-2-0036, W911NF-11-2-0020]; DoE BES [DE-AC05-00OR22725,
W-7405-ENG-36]
FX Funding for this research came through the Director's Research
Initiative at the US Army Research Laboratories under Cooperative
Agreements W911NF-11-2-0036 to New Mexico Tech and W911NF-11-2-0020 to
the University of Central Florida, respectively. The authors thank S.
Claggett for help with the sectioning of the magnetometry samples. The
authors also thank Dr. A. Haq of the Oak Ridge National Laboratory for
the neutron diffractometer experiments on POWGEN, and LANSCE, Los Alamos
National Laboratory for conducting the texture measurements on the HIPPO
neutron diffractometer. The SNS site at Oak Ridge National Laboratory
was supported by DoE BES under DE-AC05-00OR22725, and LANSCE by DoE BES
under contract W-7405-ENG-36. BSM would like to thank EPFL, in Lausanne,
Switzerland, for hosting him at the LMM in the Institute of Materials,
during the review portion of this paper.
NR 47
TC 3
Z9 3
U1 12
U2 65
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 1359-6454
EI 1873-2453
J9 ACTA MATER
JI Acta Mater.
PD SEP 15
PY 2015
VL 97
BP 245
EP 256
DI 10.1016/j.actamat.2015.06.059
PG 12
WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical
Engineering
SC Materials Science; Metallurgy & Metallurgical Engineering
GA CP4TP
UT WOS:000359875800025
PM 27099566
ER
PT J
AU Shiels, SM
Bedigrew, KM
Wenke, JC
AF Shiels, Stefanie M.
Bedigrew, Katherine M.
Wenke, Joseph C.
TI Development of a hematogenous implant-related infection in a rat model
SO BMC MUSCULOSKELETAL DISORDERS
LA English
DT Article
ID STAPHYLOCOCCUS-AUREUS; CHRONIC OSTEOMYELITIS; BIOFILM
AB Background: Implant-related osteomyelitis is a major complication that requires immediate treatment, often involving removal of the implant, prolonging patient recovery and inflating expenses. Current research involving interventions to diminish the prevalence of such measures include investigating prophylactic and therapeutic remedies. A proper and accurate animal model is needed to thoroughly investigate such treatments. The scope of this project was to develop an animal model in which a consistent and measurable infection can be formed on an orthopedic implant when bacteria is introduced via a hematogenous source.
Methods: Titanium Kirschner-wires were implanted into the intramedullary canals of both femurs. Staphylococcus aureus, ranging from 10(4) to 10(9) colony forming units, was injected into a tail vessel. After a designated time (3, 7, 14, or 42 days) the femurs were harvested and bacterial numbers determined for both the femur and the implanted K-wire. In addition, histology and micro-computed tomography were used as subjective tools to further characterize the infection.
Results: Consistent infection, that is infection of >= 75 % of the femurs, wasn't achieved until 10(7) CFU S. aureus was injected. At 10(7) CFU, the femurs contained 4.6x10(6) CFU/g bone tissue at day 3 and 4.8x10(8) CFU/g bone tissue by day 14. The wire showed comparable contamination with 4.8x10(4) CFU/mm(2) at day 3 and 3.7x10(5)/mm(2) by day 14. After 42 days, the bacteria number decreased but was still occupying at 1.9x10(5) CFU/g bone tissue. There were morphological changes to the bone as well. At day 42, there were signs of osteonecrosis and active bone formation when compared to control animals that received a K-wire but were inoculated with saline.
Conclusions: A model for hematogenous osteomyelitis, a common complication associated with implants, has been introduced. A reproducible, preclinical model is essential to evaluate future methods used to mitigate blood-borne bacteria hardware and bone infections.
C1 [Shiels, Stefanie M.; Wenke, Joseph C.] US Army, Inst Surg Res, Extrem Trauma & Regenerat Med Task Area, Jbsa Fort Sam Houston, TX 78234 USA.
[Bedigrew, Katherine M.] San Antonio Mil Med Ctr, Dept Orthopaed, Jbsa Fort Sam Houston, TX 78234 USA.
RP Shiels, SM (reprint author), US Army, Inst Surg Res, Extrem Trauma & Regenerat Med Task Area, Jbsa Fort Sam Houston, TX 78234 USA.
EM stefanie.m.shiels.vol@mail.mil
OI Shiels, Stefanie/0000-0002-5904-3107
FU US Army Medical Research and Materiel Command Combat Casualty Care
Research Program; Oakridge Institute for Science and Education
FX The work was supported by intramural funding from the US Army Medical
Research and Materiel Command Combat Casualty Care Research Program to
JCW. SMS is supported by a post-doctoral research program through the
Oakridge Institute for Science and Education. The opinions or assertions
contained herein are the private views of the author and are not to be
construed as official or as reflecting the views of the Department of
the Army or the Department of Defense.
NR 19
TC 2
Z9 2
U1 1
U2 5
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2474
J9 BMC MUSCULOSKEL DIS
JI BMC Musculoskelet. Disord.
PD SEP 14
PY 2015
VL 16
AR 255
DI 10.1186/s12891-015-0699-7
PG 8
WC Orthopedics; Rheumatology
SC Orthopedics; Rheumatology
GA CR1PB
UT WOS:000361096200005
PM 26370721
ER
PT J
AU Chang, BY
Shin, S
Malinovsky, V
Sola, IR
AF Chang, Bo Y.
Shin, Seokmin
Malinovsky, Vladimir
Sola, Ignacio R.
TI The Hydrogen molecular cation as a molecular antenna
SO JOURNAL OF PHYSICS B-ATOMIC MOLECULAR AND OPTICAL PHYSICS
LA English
DT Article
DE Electron-nuclear dynamics; Strong fields; Time-dependent Schroedinger
equation; Light-induced potentials
ID INTENSE LASER FIELDS; QUANTUM MODEL SIMULATIONS; MULTIPHOTON IONIZATION;
ELECTRON LOCALIZATION; INDUCED POTENTIALS; MG-PORPHYRIN; DISSOCIATION;
PHOTODISSOCIATION; PULSES; BOND
AB We study how the molecular hydrogen cation reacts to strong nonresonant fields, creating dipoles that oscillate at the driving carrier frequency. These dipoles are analogs of molecular antennas. The results are obtained by solving the time-dependent Schrodinger equation with simplified Hamiltonian models, assuming molecular orientation. Starting from the ground electronic state, we show under what conditions an optical molecular antenna is created and analyze its magnitude and the physical processes that lead to its disruption. Starting from the first excited electronic state we show how to generate a much larger (but unstable) far-infrared antenna that can only be created by a very intense field of specific frequency.
C1 [Chang, Bo Y.; Shin, Seokmin] Seoul Natl Univ, Sch Chem BK21, Seoul 151747, South Korea.
[Malinovsky, Vladimir] US Army Res Lab, Adelphi, MD 20783 USA.
[Sola, Ignacio R.] Univ Complutense, Dept Quim Fis, E-28040 Madrid, Spain.
RP Chang, BY (reprint author), Seoul Natl Univ, Sch Chem BK21, Seoul 151747, South Korea.
EM isola@quim.ucm.es
FU NRF Grant - Korean government [2007-0056343]; International cooperation
program [NRF-2013K2A1A2054518]; Basic Science Research program
[NRF-2013R1A1A2061898]; EDISON project [2012M3C1A6035358]; MICINN
project [CTQ2012-36184]; Korean Brain Pool Program
FX This work was supported by the NRF Grant funded by the Korean government
(2007-0056343), the International cooperation program
(NRF-2013K2A1A2054518), the Basic Science Research program
(NRF-2013R1A1A2061898), the EDISON project (2012M3C1A6035358) and the
MICINN project CTQ2012-36184. IRS gratefully acknowledges support from
the Korean Brain Pool Program.
NR 73
TC 1
Z9 1
U1 2
U2 13
PU IOP PUBLISHING LTD
PI BRISTOL
PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
SN 0953-4075
EI 1361-6455
J9 J PHYS B-AT MOL OPT
JI J. Phys. B-At. Mol. Opt. Phys.
PD SEP 14
PY 2015
VL 48
IS 17
SI SI
AR 174005
DI 10.1088/0953-4075/48/17/174005
PG 8
WC Optics; Physics, Atomic, Molecular & Chemical
SC Optics; Physics
GA CP1BE
UT WOS:000359610000007
ER
PT J
AU Eddy, MD
Brunye, TT
Tower-Richardi, S
Mahoney, CR
Taylor, HA
AF Eddy, Marianna D.
Brunye, Tad T.
Tower-Richardi, Sarah
Mahoney, Caroline R.
Taylor, Holly A.
TI The effect of a brief mindfulness induction on processing of emotional
images: an ERP study
SO FRONTIERS IN PSYCHOLOGY
LA English
DT Article
DE event-related potentials; mindfulness; focused breathing; emotion
ID STRESS REDUCTION PROGRAM; ELECTROCORTICAL RESPONSE; EVOKED-POTENTIALS;
VISUAL-STIMULI; MEDITATION; ATTENTION; MECHANISMS; ANXIETY;
INTERVENTION; REAPPRAISAL
AB The ability to effectively direct one's attention is an important aspect of regulating emotions and a component of mindfulness. Mindfulness practices have been established as effective interventions for mental and physical illness; however, the underlying neural mechanisms of mindfulness and how they relate to emotional processing have not been explored in depth. The current study used a within-subjects repeated measures design to examine if focused breathing, a brief mindfulness induction, could modulate event-related potentials (ERPs) during emotional image processing relative to a control condition. We related ERP measures of processing positive, negative, and neutral images (the P300 and late positive potential LPP) to state and trait mindfulness measures. Overall, the brief mindfulness induction condition did not influence ERPs reflecting emotional processing; however, in the brief mindfulness induction condition, those participants who reported feeling more decentered (a subscale of the Toronto Mindfulness Scale) after viewing the images had reduced P300 responses to negative versus neutral images.
C1 [Eddy, Marianna D.; Brunye, Tad T.; Mahoney, Caroline R.] US Army, Cognit Sci Team, Natick Soldier Res, Ctr Dev & Engn, Natick, MA 01760 USA.
[Eddy, Marianna D.; Brunye, Tad T.; Tower-Richardi, Sarah; Mahoney, Caroline R.; Taylor, Holly A.] Tufts Univ, Dept Psychol, Medford, MA 02155 USA.
RP Eddy, MD (reprint author), US Army, Cognit Sci Team, Natick Soldier Res, Dev & Engn Ctr,RDNS SEW THC, Bldg 45,15 Kansas St, Natick, MA 01760 USA.
EM marianna.eddy@tufts.edu
FU U.S. Army Natick Soldier Research, Development and Engineering Center
(NSRDEC) [W911-QY-13-C-0012]
FX Research reported in this publication was supported by the U.S. Army
Natick Soldier Research, Development and Engineering Center (NSRDEC)
under award number W911-QY-13-C-0012. The content is solely the
responsibility of the authors and does not necessarily represent the
views of NSRDEC or the U.S. Army.
NR 39
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Z9 2
U1 4
U2 21
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015,
SWITZERLAND
SN 1664-1078
J9 FRONT PSYCHOL
JI Front. Psychol.
PD SEP 11
PY 2015
VL 6
DI 10.3389/fpsyg.2015.01391
PG 12
WC Psychology, Multidisciplinary
SC Psychology
GA CR1EH
UT WOS:000361066100001
ER
PT J
AU Zhang, SS
Tran, DT
AF Zhang, Sheng S.
Tran, Dat T.
TI Electrochemical verification of the redox mechanism of FeS2 in a
rechargeable lithium battery
SO ELECTROCHIMICA ACTA
LA English
DT Article
DE Iron pyrite; Li/FeS2 battery; Li/S battery; Impedance; Redox mechanism
ID SOLID-ELECTROLYTE INTERFACE; POLYMER ELECTROLYTE; POSITIVE ELECTRODES;
PHASE-RELATIONSHIPS; PYRITE; TEMPERATURE; DISULFIDE; GRAPHITE; CRYSTAL;
CATHODE
AB The redox mechanism of micro-sized FeS2 particles in a rechargeable lithium battery is studied by galvanostatic cycling and ac-impedance analysis. It is shown that FeS2 is irreversibly reduced on the first discharge, turning Li/FeS2 cell into a combination of Li/FeS and Li/S chemistries, as suggested by two distinct discharge plateaus at similar to 1.5 and 2.0 V, respectively. The first discharge consists of an irreversible conversion of FeS2 to Li2FeS2 intermediate and its subsequent reduction to metallic Fe and Li2S. The first discharge suffers an initial voltage delay, suggesting that the discharge progresses in a thermodynamic non-equilibrium condition. The initial voltage delay can be attributed to the large grain boundary resistance (GBR) of pristine FeS2 particles, which impedes the nucleation of a new solid Li2FeS2 phase causing high polarization. Ac-impedance spectra of the FeS2 cathode are composed of a semicircle and a straight sloping line, representative of an electrode reaction resistance (R-er) and a Li+ adsorption impedance, respectively. The R-er is found to decrease progressively during the first discharge and reaches a plateau when the cell is charged above 2.5 V vs. Li/Li+, being consistent with the model that FeS2 is irreversibly reduced during the first discharge and that the Li2S/Li2Sn redox couple is formed in recharge. It is indicated that Li/FeS2 batteries face the same problems as Li/S batteries, such as the dissolution of lithium polysulfide, the formation of a redox shuttle, and the loss of sulfur active material. Published by Elsevier Ltd.
C1 [Zhang, Sheng S.; Tran, Dat T.] US Army, Electrochem Branch, RDRL SED C, Sensors & Electron Devices Directorate,Res Lab, Adelphi, MD 20783 USA.
RP Zhang, SS (reprint author), US Army, Electrochem Branch, RDRL SED C, Sensors & Electron Devices Directorate,Res Lab, Adelphi, MD 20783 USA.
EM shengshui.zhang.civ@mail.mil
RI Zhang, Sheng/A-4456-2012
OI Zhang, Sheng/0000-0003-4435-4110
NR 31
TC 11
Z9 11
U1 27
U2 135
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0013-4686
EI 1873-3859
J9 ELECTROCHIM ACTA
JI Electrochim. Acta
PD SEP 10
PY 2015
VL 176
BP 784
EP 789
DI 10.1016/j.electacta.2015.07.096
PG 6
WC Electrochemistry
SC Electrochemistry
GA CQ9FK
UT WOS:000360918000095
ER
PT J
AU Thomas, SJ
AF Thomas, Stephen J.
TI NS1: A corner piece in the dengue pathogenesis puzzle?
SO SCIENCE TRANSLATIONAL MEDICINE
LA English
DT Editorial Material
ID VIRUS; ANTIGEN; MICE
AB Soluble dengue virus NS1 protein induces proinflammatory immune responses via Toll-like receptor 4 and disrupts endothelial cell integrity, resulting in vascular leakage (Beatty et al. and Modhiran et al., this issue).
C1 Walter Reed Army Inst Res, Silver Spring, MD 20910 USA.
RP Thomas, SJ (reprint author), Walter Reed Army Inst Res, Silver Spring, MD 20910 USA.
EM stephen.j.thomas3.mil@mail.mil
NR 10
TC 3
Z9 3
U1 0
U2 2
PU AMER ASSOC ADVANCEMENT SCIENCE
PI WASHINGTON
PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA
SN 1946-6234
EI 1946-6242
J9 SCI TRANSL MED
JI Sci. Transl. Med.
PD SEP 9
PY 2015
VL 7
IS 304
AR 304fs37
DI 10.1126/scitranslmed.aad1255
PG 3
WC Cell Biology; Medicine, Research & Experimental
SC Cell Biology; Research & Experimental Medicine
GA CQ9OG
UT WOS:000360943900001
PM 26355028
ER
PT J
AU Bigley, AN
Mabanglo, MF
Harvey, SP
Raushel, FM
AF Bigley, Andrew N.
Mabanglo, Mark F.
Harvey, Steven P.
Raushel, Frank M.
TI Variants of Phosphotriesterase for the Enhanced Detoxification of the
Chemical Warfare Agent VR
SO BIOCHEMISTRY
LA English
DT Article
ID ORGANOPHOSPHATE NERVE AGENTS; BACTERIAL PHOSPHOTRIESTERASE;
PSEUDOMONAS-DIMINUTA; DIRECTED EVOLUTION; HYDROLYSIS; VX; SUBSTRATE;
DEGRADATION; HYDROLASE; ENZYMES
AB The V-type organophosphorus nerve agents are among the most hazardous compounds known. Previous efforts to evolve the bacterial enzyme phosphotriesterase (PTE) for the hydrolytic decontamination of VX resulted in the identification of the variant L7ep-3a, which has a k(cat) value more than 2 orders of magnitude higher than that of wild-type PTE for the hydrolysis of VX. Because of the relatively small size of the O-ethyl, methylphosphonate center in VX, stereoselectivity is not a major concern. However, the Russian V-agent, VR, contains a larger O-isobutyl, methylphosphonate center, making stereoselectivity a significant issue since the S-P-enantiomer is expected to be significantly more toxic than the R-P-enantiomer. The three-dimensional structure of the L7ep-3a variant was determined to a resolution of 2.01 angstrom (PDB id: 4ZST). The active site of the L7ep-3a mutant has revealed a network of hydrogen bonding interactions between Asp-301, Tyr-257, Gln-254, and the hydroxide that bridges the two metal ions. A series of new analogues that mimic VX and VR has helped to identify critical structural features for the development of new enzyme variants that are further enhanced for the catalytic detoxification of VR and VX. The best of these mutants has been shown to have a reversed stereochemical preference for the hydrolysis of VR-chiral center analogues. This mutant hydrolyzes the two enantiomers of VR 160- and 600-fold faster than wild-type PTE hydrolyzes the Sp-enantiomer of VR.
C1 [Bigley, Andrew N.; Mabanglo, Mark F.; Raushel, Frank M.] Texas A&M Univ, Dept Chem, College Stn, TX 77843 USA.
[Harvey, Steven P.] US Army Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA.
RP Raushel, FM (reprint author), Texas A&M Univ, Dept Chem, College Stn, TX 77843 USA.
EM raushel@tamu.edu
FU Defense Threat Reduction Agency [HDTRA1-14-1-0004]
FX This work was supported by the Defense Threat Reduction Agency
(HDTRA1-14-1-0004).
NR 33
TC 7
Z9 7
U1 10
U2 22
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0006-2960
J9 BIOCHEMISTRY-US
JI Biochemistry
PD SEP 8
PY 2015
VL 54
IS 35
BP 5502
EP 5512
DI 10.1021/acs.biochem.5b00629
PG 11
WC Biochemistry & Molecular Biology
SC Biochemistry & Molecular Biology
GA CR1LO
UT WOS:000361086500012
PM 26274608
ER
PT J
AU Wise, AM
Ban, CM
Weker, JN
Misra, S
Cavanagh, AS
Wu, ZC
Li, Z
Whittingham, MS
Xu, K
George, SM
Toney, MF
AF Wise, Anna M.
Ban, Chunmei
Weker, Johanna Nelson
Misra, Sumohan
Cavanagh, Andrew S.
Wu, Zhuangchun
Li, Zheng
Whittingham, M. Stanley
Xu, Kang
George, Steven M.
Toney, Michael F.
TI Effect of Al2O3 Coating on Stabilizing LiNi0.4Mn0.4Co0.2O2 Cathodes
SO CHEMISTRY OF MATERIALS
LA English
DT Article
ID LITHIUM-ION BATTERIES; ATOMIC LAYER DEPOSITION; X-RAY-DIFFRACTION;
IN-SITU XRD; ELECTROCHEMICAL-BEHAVIOR; STRUCTURAL-CHANGES; RATE
CAPABILITY; ABSORPTION SPECTROSCOPY; CAPACITY RETENTION; SURFACE
AB Using atomic layer deposition of Al2O3 coating, improved high-voltage cycling stability has been demonstrated for the layered nickelmanganesecobalt pseudoternary oxide, LiNi0.4Mn0.4Co0.2O2. To understand the effect of the Al2O3 coating, we have utilized electrochemical impedance spectroscopy, operando synchrotron-based X-ray diffraction, and operando X-ray absorption near edge fine structure spectroscopy to characterize the structure and chemistry evolution of the LiNi0.4Mn0.4Co0.2O2 cathode during cycling. Using this combination of techniques, we show that the Al2O3 coating successfully mitigates the strong side reactions of the active material with the electrolyte at higher voltages (>4.4 V), without restricting the uptake and release of Li ions. The impact of the Al2O3 coating is also revealed at beginning of lithium deintercalation, with an observed delay in the evolution of oxidation and coordination environment for the Co and Mn ions in the coated electrode due to protection of the surface. This protection prevents the competing side reactions of the electrolyte with the highly active Ni oxide sites, promoting charge compensation via the oxidation of Ni and enabling high-voltage cycling stability.
C1 [Wise, Anna M.; Weker, Johanna Nelson; Misra, Sumohan; Toney, Michael F.] SLAG Natl Accelerator Lab, Stanford Synchrotron Radiat Lightsource, Menlo Pk, CA 94025 USA.
[Ban, Chunmei; Wu, Zhuangchun] Natl Renewable Energy Lab, Ctr Chem & Mat Sci, Golden, CO 80401 USA.
[Cavanagh, Andrew S.; George, Steven M.] Univ Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA.
[Li, Zheng; Whittingham, M. Stanley] Binghamton Univ, Chem & Mat Sci & Engn, Binghamton, NY USA.
[Xu, Kang] US Army, Res Lab, Sensor & Elect Directorate, Adelphi, MD USA.
RP Ban, CM (reprint author), Natl Renewable Energy Lab, Ctr Chem & Mat Sci, Golden, CO 80401 USA.
EM chunmei.ban@nrel.gov; mftoney@slac.stanford.edu
RI George, Steven/O-2163-2013
OI George, Steven/0000-0003-0253-9184
FU Assistant Secretary for Energy Efficiency and Renewable Energy, Office
of Vehicle Technologies, U.S. Department of Energy under the Advanced
Battery Materials Research [DE-AC-36-08GO28308, NFT-8-88527-01];
Department of Energy, Laboratory Directed Research and Development at
SLAC National Accelerator Laboratory [DE-AC02-76SF00515]; U.S.
Department of Energy, Office of Science, Office of Basic Energy Sciences
[DE-AC02-76SF00515]
FX This work was supported by the Assistant Secretary for Energy Efficiency
and Renewable Energy, Office of Vehicle Technologies, for the U.S.
Department of Energy under Contract DE-AC-36-08GO28308, subcontract
NFT-8-88527-01 under the Batteries for Advanced Transportation
Technologies Program (now Advanced Battery Materials Research), and by
the Department of Energy, Laboratory Directed Research and Development
funding at SLAC National Accelerator Laboratory under Contract
DE-AC02-76SF00515. Use of the Stanford Synchrotron Radiation
Lightsource, SLAC National Accelerator Laboratory, is supported by the
U.S. Department of Energy, Office of Science, Office of Basic Energy
Sciences, under Contract DE-AC02-76SF00515.
NR 43
TC 16
Z9 16
U1 9
U2 115
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0897-4756
EI 1520-5002
J9 CHEM MATER
JI Chem. Mat.
PD SEP 8
PY 2015
VL 27
IS 17
BP 6146
EP 6154
DI 10.1021/acs.chemmater.5b02952
PG 9
WC Chemistry, Physical; Materials Science, Multidisciplinary
SC Chemistry; Materials Science
GA CR1LK
UT WOS:000361086100042
ER
PT J
AU Kantner, J
Vettel, JM
Miller, MB
AF Kantner, Justin
Vettel, Jean M.
Miller, Michael B.
TI Dubious decision evidence and criterion flexibility in recognition
memory
SO FRONTIERS IN PSYCHOLOGY
LA English
DT Article
DE recognition; decision making; criterion shifting; response bias;
feedback
ID SIGNAL-DETECTION; BASE-RATE; PERCEPTUAL CATEGORIZATION; RESPONSE BIAS;
FEEDBACK; STRENGTH; PERFORMANCE; PLACEMENT; SHIFTS
AB When old-new recognition judgments must be based on ambiguous memory evidence, a proper criterion for responding "old" can substantially improve accuracy, but participants are typically suboptimal in their placement of decision criteria. Various accounts of suboptimal criterion placement have been proposed. The most parsimonious, however, is that subjects simply over-rely on memory evidence - however faulty - as a basis for decisions. We tested this account with a novel recognition paradigm in which old-new discrimination was minimal and critical errors were avoided by adopting highly liberal or conservative biases. In Experiment 1, criterion shifts were necessary to adapt to changing target probabilities or, in a "security patrol" scenario, to avoid either letting dangerous people go free (misses) or harming innocent people (false alarms). Experiment 2 added a condition in which financial incentives drove criterion shifts. Critical errors were frequent, similar across sources of motivation, and only moderately reduced by feedback. In Experiment 3, critical errors were only modestly reduced in a version of the security patrol with no study phase. These findings indicate that participants use even transparently non-probative information as an alternative to heavy reliance on a decision rule, a strategy that precludes optimal criterion placement.
C1 [Kantner, Justin; Vettel, Jean M.] US Army Res Lab, Aberdeen, MD USA.
[Kantner, Justin; Vettel, Jean M.; Miller, Michael B.] Univ Calif Santa Barbara, Santa Barbara, CA 93106 USA.
RP Kantner, J (reprint author), Washington Univ, Dept Psychol, One Brookings Dr,Campus Box 1125, St Louis, MO 63130 USA.
EM jkantner@wustl.edu
FU U.S. Army Research Laboratory; U.S. Army Research Office; Institute for
Collaborative Biotechnologies [W911NF-12-2-0019, W911NF-10-2-0022,
W911NF-09-D-0001]
FX Research was sponsored by the U.S. Army Research Laboratory and U.S.
Army Research Office and supported by the Institute for Collaborative
Biotechnologies under Cooperative Agreement Numbers W911NF-12-2-0019,
W911NF-10-2-0022, and W911NF-09-D-0001. The views and conclusions
contained in this document are those of the authors and should not be
interpreted as representing the official policies, either expressed or
implied, of the Army Research Laboratory or the U.S. Government. The
U.S. Government is authorized to reproduce and distribute reprints for
Government purposes notwithstanding any copyright notation herein. We
thank Deanna Falge, Amber Miller, and Devon Sandel for their assistance
with data collection, and Matthew Jaswa for generating the stimuli.
NR 29
TC 0
Z9 0
U1 1
U2 4
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015,
SWITZERLAND
SN 1664-1078
J9 FRONT PSYCHOL
JI Front. Psychol.
PD SEP 8
PY 2015
VL 6
AR 1320
DI 10.3389/fpsyg.2015.01320
PG 18
WC Psychology, Multidisciplinary
SC Psychology
GA CQ6IX
UT WOS:000360709100001
PM 26441706
ER
PT J
AU Sabatini, JJ
Koch, EC
Poret, JC
Moretti, JD
Harbol, SM
AF Sabatini, Jesse J.
Koch, Ernst-Christian
Poret, Jay C.
Moretti, Jared D.
Harbol, Seth M.
TI Chlorine-Free Red-Burning Pyrotechnics
SO ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
LA English
DT Article
DE energetic materials; illumination; pyrotechnics; red flames; sustainable
chemistry
ID LIGHT EMITTER; BORON-CARBIDE; GREEN; PERFORMANCE; MAGNESIUM; DIOXINS;
METAL
AB The development of a red, chlorine-free pyrotechnic illuminant of high luminosity and spectral purity was investigated. Red-light emission based solely on transient SrOH(g) has been achieved by using either 5-amino-1H-tetrazole or hexamine to deoxidize the combustion flame of a Mg/Sr(NO3)(2)/Epon-binder composition and reduce the amount of both condensed and gaseous SrO, which emits undesirable orange-red light. The new formulations were found to possess high thermal onset temperatures. Avoiding chlorine in these formulations eliminates the risk of the formation of PCBs, PCDDs, and PCDFs. This finding, hence, will have a great impact on both military pyrotechnics and commercial firework sectors.
C1 [Koch, Ernst-Christian] Lutradyn Energet Mat Sci & Technol, D-67661 Kaiserslautern, Germany.
[Sabatini, Jesse J.] US Army, Res Lab, Energet Technol Branch, Aberdeen Proving Ground, MD 21005 USA.
[Poret, Jay C.; Moretti, Jared D.] US Army RDECOM ARDEC, Pyrotech Technol & Prototyping Div, Picatinny Arsenal, Picatinny Arsenal, NJ 07806 USA.
RP Sabatini, JJ (reprint author), US Army, Res Lab, Energet Technol Branch, Aberdeen Proving Ground, MD 21005 USA.
EM jesse.j.sabatini.civ@mail.mil; e-c.koch@lutradyn.com
NR 27
TC 2
Z9 2
U1 2
U2 24
PU WILEY-V C H VERLAG GMBH
PI WEINHEIM
PA BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY
SN 1433-7851
EI 1521-3773
J9 ANGEW CHEM INT EDIT
JI Angew. Chem.-Int. Edit.
PD SEP 7
PY 2015
VL 54
IS 37
BP 10968
EP 10970
DI 10.1002/anie.201505829
PG 3
WC Chemistry, Multidisciplinary
SC Chemistry
GA CQ5FK
UT WOS:000360628500050
PM 26333055
ER
PT J
AU Borodin, O
Olguin, M
Spear, CE
Leiter, KW
Knap, J
AF Borodin, Oleg
Olguin, Marco
Spear, Carrie E.
Leiter, Kenneth W.
Knap, Jaroslaw
TI Towards high throughput screening of electrochemical stability of
battery electrolytes
SO NANOTECHNOLOGY
LA English
DT Article
DE quantum chemistry; battery; electrolyte
ID LITHIUM-ION BATTERIES; DENSITY-FUNCTIONAL THEORY; OXIDATION-INDUCED
DECOMPOSITION; UNDERSTAND SURFACE-CHEMISTRY; TOTAL-ENERGY CALCULATIONS;
SOLID-STATE REACTION; WAVE BASIS-SET; ETHYLENE CARBONATE; PROPYLENE
CARBONATE; MOLECULAR-DYNAMICS
AB High throughput screening of solvents and additives with potential applications in lithium batteries is reported. The initial test set is limited to carbonate and phosphate-based compounds and focused on their electrochemical properties. Solvent stability towards first and second reduction and oxidation is reported from density functional theory (DFT) calculations performed on isolated solvents surrounded by implicit solvent. The reorganization energy is estimated from the difference between vertical and adiabatic redox energies and found to be especially important for the accurate prediction of reduction stability. A majority of tested compounds had the second reduction potential higher than the first reduction potential indicating that the second reduction reaction might play an important role in the passivation layer formation. Similarly, the second oxidation potential was smaller for a significant subset of tested molecules than the first oxidation potential. A number of potential sources of errors introduced during screening of the electrolyte electrochemical properties were examined. The formation of lithium fluoride during reduction of semifluorinated solvents such as fluoroethylene carbonate and the H-transfer during oxidation of solvents were found to shift the electrochemical potential by 1.5-2 V and could shrink the electrochemical stability window by as much as 3.5 V when such reactions are included in the screening procedure. The initial oxidation reaction of ethylene carbonate and dimethyl carbonate at the surface of the completely de-lithiated LiNi0.5Mn1.5O4 high voltage spinel cathode was examined using DFT. Depending on the molecular orientation at the cathode surface, a carbonate molecule either exhibited deprotonation or was found bound to the transition metal via its carbonyl oxygen.
C1 [Borodin, Oleg; Olguin, Marco] US Army Res Lab, Electrochem Branch, RDRL SED C, Adelphi, MD 20783 USA.
[Spear, Carrie E.; Leiter, Kenneth W.; Knap, Jaroslaw] US Army Res Lab, Simulat Sci Branch, RDRL CIH C, Aberdeen Proving Ground, MD 21005 USA.
RP Borodin, O (reprint author), US Army Res Lab, Electrochem Branch, RDRL SED C, Powder Mill Rd 2800, Adelphi, MD 20783 USA.
EM oleg.a.borodin.civ@mail.mil
RI Borodin, Oleg/B-6855-2012
OI Borodin, Oleg/0000-0002-9428-5291
FU ARL Enterprise by Multiscale Modeling; Oak Ridge Associated Universities
(ORAU) Postdoctoral Fellowship
FX Discussions of screening results with Samuel Delp and Arthur von Cresce
from ARL are highly appreciated. Adam Childs, help with running quantum
chemistry jobs is highly appreciated. Research was supported by ARL
Enterprise by Multiscale Modeling. MO was supported by an Oak Ridge
Associated Universities (ORAU) Postdoctoral Fellowship.
NR 115
TC 22
Z9 22
U1 8
U2 86
PU IOP PUBLISHING LTD
PI BRISTOL
PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
SN 0957-4484
EI 1361-6528
J9 NANOTECHNOLOGY
JI Nanotechnology
PD SEP 4
PY 2015
VL 26
IS 35
AR 354003
DI 10.1088/0957-4484/26/35/354003
PG 15
WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary;
Physics, Applied
SC Science & Technology - Other Topics; Materials Science; Physics
GA CQ9PN
UT WOS:000360947200004
PM 26266636
ER
PT J
AU Johnson, T
AF Johnson, Todd
TI The Quiet Man: The Indispensable Presidency of George H.W. Bush
SO RUSI Journal
LA English
DT Book Review
C1 [Johnson, Todd] US Army, Fort Knox, KY 40122 USA.
[Johnson, Todd] US Naval War Coll, Natl Secur Affairs Dept, Newport, RI USA.
RP Johnson, T (reprint author), US Army, Fort Knox, KY 40122 USA.
NR 1
TC 0
Z9 0
U1 1
U2 1
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 0307-1847
EI 1744-0378
J9 RUSI J
JI RUSI J.
PD SEP 3
PY 2015
VL 160
IS 5
BP 90
EP 91
DI 10.1080/03071847.2015.1102562
PG 2
WC Political Science
SC Government & Law
GA CV5UB
UT WOS:000364335600007
ER
PT J
AU Weingarten, NS
Sausa, RC
AF Weingarten, N. Scott
Sausa, Rosario C.
TI Nanomechanics of RDX Single Crystals by Force-Displacement Measurements
and Molecular Dynamics Simulations
SO JOURNAL OF PHYSICAL CHEMISTRY A
LA English
DT Article
ID CYCLOTRIMETHYLENE TRINITRAMINE RDX; PLASTIC-BONDED EXPLOSIVES; ENERGETIC
MATERIALS; ELASTIC-MODULUS; PENTAERYTHRITOL TETRANITRATE; INSTRUMENTED
INDENTATION; NANOINDENTATION; HARDNESS; DEFECT; DISLOCATIONS
AB Nanoenergetic material modifications for enhanced performance and stability require an understanding of the mechanical properties and molecular structure-property relationships of materials. We investigate the mechanical and tribological properties of single-crystal hexahydro-1,3,5-trinitro-s-triazine (RDX) by forcedisplacement microscopy and molecular dynamics (MD). Our MD simulations reveal the RDX reduced modulus (E-r) depends on the particular crystallographic surface. The predicted E-r values for the respective (210) and (001) surfaces are 26.8 and 21.0 GPa. Further, our simulations reveal a symmetric and fairly localized deformation occurring on the (001) surface compared to an asymmetric deformation on the (210) surface. The predicted hardness (H) values are nearly equal for both surfaces. The predicted E-r and H values are similar to 33% and 17% greater than the respective experimental values of 0.798 +/- 0.030 GPa and 22.9 +/- 0.7 GPa for the (210) surface and even larger than those reported previously. Our experimental H and E-r values are similar to 19% and 9% greater than those reported previously for the (210) surface. The difference between the experimental values reported here and elsewhere stems in part from an inaccurate determination of the contact area. We employ the parameter root H/E-r, which is independent of area, as a means to compare present and past results, and find excellent agreement, within a few percent, between our predicted and experimental results and between our results and those obtained from previous nanoindentation experiments. Also, we performed nanoscratch simulations of the (210) and (001) surfaces and nanoscratch tests on the (210) surface and present values of the dynamic coefficient of deformation friction.
C1 [Weingarten, N. Scott; Sausa, Rosario C.] US Army Res Lab, ARL RDRL WML B, 4600 Deer Creek Loop, Aberdeen Proving Ground, MD 21005 USA.
RP Sausa, RC (reprint author), US Army Res Lab, ARL RDRL WML B, 4600 Deer Creek Loop, Aberdeen Proving Ground, MD 21005 USA.
EM rosario.c.sausa.civ@mail.mil
FU ARL Multiscale Response of Energetic Materials Program
FX We thank Drs. D. Taylor and K. Strawhecker of the Army Research
Laboratory (ARL) for many helpful discussions, and Dr. K. Ramos of the
Los Alamos National Laboratory for providing us with the RDX crystals.
Computer support was provided by the DOD Supercomputing Resource Centers
at ARL and AFRL. Support from the ARL Multiscale Response of Energetic
Materials Program is also gratefully acknowledged.
NR 71
TC 3
Z9 3
U1 1
U2 23
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1089-5639
J9 J PHYS CHEM A
JI J. Phys. Chem. A
PD SEP 3
PY 2015
VL 119
IS 35
BP 9338
EP 9351
DI 10.1021/acs.jpca.5b04876
PG 14
WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical
SC Chemistry; Physics
GA CQ9PS
UT WOS:000360947700016
PM 26264509
ER
PT J
AU Omar, MY
Xiang, CC
Gupta, N
Strbik, OM
Cho, K
AF Omar, Mohammed Yaseer
Xiang, Chongchen
Gupta, Nikhil
Strbik, Oliver M., III
Cho, Kyu
TI Syntactic foam core metal matrix sandwich composite: Compressive
properties and strain rate effects
SO MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES
MICROSTRUCTURE AND PROCESSING
LA English
DT Article
DE Metal matrix composite; Sandwich composite; Syntactic foam; Compression
testing; High strain rate compression
ID DEFORMATION-BEHAVIOR; MECHANICAL-PROPERTIES; CERAMIC MICROSPHERES; A356
ALLOY; DAMAGE; BEAM; IRON
AB The present work is the first attempt to study metal matrix syntactic foam core sandwich composites. The sandwich is studied for microstructure and compressive properties at quasi-static and high strain rates. Under quasi-static compressive conditions, specimens were tested in the flatwise and edgewise orientations. The compressive strength, yield strength and plateau stress were higher in the flatwise orientation. Furthermore, both orientations for the sandwich composites showed a higher specific compressive strength and specific yield strength than the foam core alone. Failure initiated in the particles in the flatwise orientation, but in the carbon fabrics in the edgewise orientation. The results show that the fabric had a reinforcing effect under quasi-static conditions. The high strain rate (HSR) characterization was conducted in the strain rate range 525-845 s(-1) using a split-Hopkinson pressure bar set-up equipped with a high speed image acquisition system. Within this strain rate range, the compressive strength of the sandwich is similar to that of the syntactic foam core alone. Upon review, the syntactic foam core metal matrix sandwich outperforms most of the syntactic foams in terms of energy absorption and compressive strength at comparable density levels. (C) 2015 Elsevier B.V. All rights reserved.
C1 [Omar, Mohammed Yaseer; Xiang, Chongchen; Gupta, Nikhil] NYU, Polytech Sch Engn, Dept Mech & Aerosp Engn, Composite Mat & Mech Lab, Brooklyn, NY 11201 USA.
[Strbik, Oliver M., III] Deep Springs Technol Inc, Toledo, OH 43615 USA.
[Cho, Kyu] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA.
RP Gupta, N (reprint author), NYU, Polytech Sch Engn, Dept Mech & Aerosp Engn, Composite Mat & Mech Lab, 6 MetroTech Ctr, Brooklyn, NY 11201 USA.
EM ngupta@nyu.edu
OI gupta, nikhil/0000-0001-7128-4459
FU U.S. Army Research Laboratory [W911NF-10-2-0084]; DST; NYU
[W911NF-11-2-0096]; NSF [IIA-445686]; NYUAD Vice Chancellor's office
FX This research is sponsored by the U.S. Army Research Laboratory contract
W911NF-10-2-0084 with DST and the Cooperative Agreement W911NF-11-2-0096
with NYU. Partial support from NSF grant IIA-445686 is also
acknowledged. The authors acknowledge scholarship from the NYUAD Vice
Chancellor's office to Mohammed. Dr. Magued Iskander is thanked for
providing access to the high speed camera system. Dr. Dung Dinh Luong,
Chong-chen Xiang and Steven E. Zeltmann are thanked for help during the
research work.
NR 49
TC 3
Z9 3
U1 4
U2 19
PU ELSEVIER SCIENCE SA
PI LAUSANNE
PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND
SN 0921-5093
EI 1873-4936
J9 MAT SCI ENG A-STRUCT
JI Mater. Sci. Eng. A-Struct. Mater. Prop. Microstruct. Process.
PD SEP 3
PY 2015
VL 643
BP 156
EP 168
DI 10.1016/j.msea.2015.07.033
PG 13
WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary;
Metallurgy & Metallurgical Engineering
SC Science & Technology - Other Topics; Materials Science; Metallurgy &
Metallurgical Engineering
GA CP9XX
UT WOS:000360250300020
ER
PT J
AU Arrigo, JM
DeBatto, D
Rockwood, L
Mawe, TG
AF Arrigo, Jean Maria
DeBatto, David
Rockwood, Lawrence
Mawe, Timothy G.
TI The "Good" Psychologist, "Good" Torture, and "Good" Reputation-Response
to O'Donohue, Snipes, Dalto, Soto, Maragakis, and Im (2014) "The Ethics
of Enhanced Interrogations and Torture"
SO ETHICS & BEHAVIOR
LA English
DT Editorial Material
DE American Psychological Association; military ethics; professional
ethics; psychological ethics; torture interrogation
ID ARGUMENT
AB O'Donohue et al. (2014) sought to derive, from classical ethical theories, the ethical obligation of psychologists to assist enhanced interrogations and torture (EIT) in national defense scenarios under strict EIT criteria. They asked the American Psychological Association to adopt an ethics code obligating psychologists to assist such EIT and to uphold the reputation of EIT psychologists. We contest the authors' ethical analyses as supports for psychologists' forays into torture interrogation when (if ever) the EIT criteria obtain. We also contend that the authors' application of these ethical analyses violates the Geneva Conventions, contravenes military doctrine and operations, and undermines psychology as a profession. We conclude that good public reputation is not owed to, or expected by, good intelligence professionals, and collaborating operational psychologists must share their providence.
C1 [Arrigo, Jean Maria] Project Eth & Art Testimony Inc, Irvine, CA USA.
[DeBatto, David] US Army, Washington, DC USA.
[Mawe, Timothy G.] Univ Cork, Dept Philosophy, Cork, Ireland.
RP Arrigo, JM (reprint author), 110 Oxford St, Irvine, CA 92612 USA.
EM jmarrigo@peat-intel.org
NR 41
TC 0
Z9 0
U1 1
U2 4
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 1050-8422
EI 1532-7019
J9 ETHICS BEHAV
JI Ethics Behav.
PD SEP 3
PY 2015
VL 25
IS 5
BP 361
EP 372
DI 10.1080/10508422.2015.1007996
PG 12
WC Ethics; Psychology, Multidisciplinary
SC Social Sciences - Other Topics; Psychology
GA CP3QS
UT WOS:000359796300001
ER
PT J
AU Person, R
AF Person, Robert
TI Potholes, pensions, and public opinion: the politics of blame in Putin's
power vertical
SO POST-SOVIET AFFAIRS
LA English
DT Article
DE authoritarianism; Russia; accountability; centralization; elections;
Putin; public opinion
AB What are the risks and rewards of power centralization in competitive authoritarian regimes, and who in the regime bears those risks and enjoys the rewards? The elimination of gubernatorial elections in Russia in late 2004 provides a unique opportunity to study public reaction to policies that replaced democratically elected regional leaders with Kremlin appointees, thereby further concentrating power in the hands of the central state while simultaneously reducing the level of democratic accountability in Russian politics. Using a 2007 survey of 1500 Russians, it is possible to observe how key measures of public opinion and regime support were influenced by the elimination of gubernatorial elections. Because the timeline of gubernatorial appointments was determined exogenously based on the expiration of elected incumbent governors' terms, by 2007 some regions had governors who still held electoral mandates, while others had Kremlin appointees with no electoral mandate. This quasi experiment allows us to draw surprising conclusions about whom Russians blame - and do not blame - when power becomes increasingly centralized in the hands of the president.
C1 US Mil Acad, West Point, NY 10996 USA.
RP Person, R (reprint author), US Mil Acad, West Point, NY 10996 USA.
EM robert.person@usma.edu
FU MacMillan Center for International and Area Studies at Yale University
FX I am grateful for the support of the MacMillan Center for International
and Area Studies at Yale University for its generous funding of the
research. I also wish to thank Tim Frye, David Szakonyi, John Reuter,
Israel Marques, James Warhola, and Thom Sherlock for helpful comments on
drafts of this paper. An earlier version of this paper was presented at
the annual meeting of the Midwest Political Science Association.
NR 45
TC 0
Z9 0
U1 0
U2 16
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 1060-586X
EI 1938-2855
J9 POST-SOV AFF
JI Post-Sov. Aff.
PD SEP 3
PY 2015
VL 31
IS 5
BP 421
EP 448
DI 10.1080/1060586X.2014.932142
PG 28
WC Area Studies; Economics; Political Science
SC Area Studies; Business & Economics; Government & Law
GA CK7OO
UT WOS:000356422100001
ER
PT J
AU Merriam, JJ
Schmitt, MN
AF Merriam, John J.
Schmitt, Michael N.
TI ISRAELI TARGETING A Legal Appraisal
SO NAVAL WAR COLLEGE REVIEW
LA English
DT Article
C1 [Merriam, John J.] US Army, Montgomery, AL 36112 USA.
[Schmitt, Michael N.] Naval War Coll, Newport, RI USA.
[Schmitt, Michael N.] Stockton Ctr, Stockton, CA USA.
[Schmitt, Michael N.] Univ Exeter, Publ Int Law, Exeter EX4 4QJ, Devon, England.
[Schmitt, Michael N.] Harvard Univ, Sch Law, Program Int Law & Armed Conflict, Cambridge, MA 02138 USA.
RP Merriam, JJ (reprint author), US Army, Montgomery, AL 36112 USA.
NR 34
TC 0
Z9 0
U1 1
U2 1
PU US NAVAL WAR COLL
PI NEWPORT
PA 686 CUSHING RD, NEWPORT, RI 02841 USA
SN 0028-1484
J9 NAV WAR COLL REV
JI Nav. War Coll. Rev.
PD FAL
PY 2015
VL 68
IS 4
BP 15
EP +
PG 20
WC International Relations
SC International Relations
GA DP3ZW
UT WOS:000378436100002
ER
PT J
AU Scobell, A
McMahon, M
Cooper, CA
AF Scobell, Andrew
McMahon, Michael
Cooper, Cortez A., III
TI CHINA'S AIRCRAFT CARRIER PROGRAM Drivers, Developments, Implications
SO NAVAL WAR COLLEGE REVIEW
LA English
DT Article
ID NAVAL NATIONALISM
C1 [Scobell, Andrew; Cooper, Cortez A., III] RAND Corp, Santa Monica, CA 90406 USA.
[Scobell, Andrew] Georgetown Univ, Edmund A Walsh Sch Foreign Serv, Washington, DC 20057 USA.
[McMahon, Michael] RANDs Natl Def Res Inst, Acquisit Technol & Policy Ctr, Santa Monica, CA USA.
[McMahon, Michael] US Navy, Washington, DC USA.
[McMahon, Michael] US Navy, Aircraft Carriers, Washington, DC USA.
[McMahon, Michael] Shipbldg Navy, Newport, RI USA.
[Cooper, Cortez A., III] Hicks & Associates Inc, Florence, AL USA.
[Cooper, Cortez A., III] US Navy Execut Serv, US Pacific Command, Joint Intelligence Ctr Pacific, Washington, DC USA.
[Cooper, Cortez A., III] US Army, Montgomery, AL USA.
RP Scobell, A (reprint author), RAND Corp, Santa Monica, CA 90406 USA.
NR 23
TC 0
Z9 0
U1 2
U2 2
PU US NAVAL WAR COLL
PI NEWPORT
PA 686 CUSHING RD, NEWPORT, RI 02841 USA
SN 0028-1484
J9 NAV WAR COLL REV
JI Nav. War Coll. Rev.
PD FAL
PY 2015
VL 68
IS 4
BP 65
EP +
PG 16
WC International Relations
SC International Relations
GA DP3ZW
UT WOS:000378436100005
ER
PT J
AU Armstrong, B
AF Armstrong, Benjamin
TI THE NEW YOUNG TURKS
SO NAVAL WAR COLLEGE REVIEW
LA English
DT Article
C1 [Armstrong, Benjamin] US Army, Montgomery, AL 36112 USA.
RP Armstrong, B (reprint author), US Army, Montgomery, AL 36112 USA.
NR 10
TC 0
Z9 0
U1 0
U2 0
PU US NAVAL WAR COLL
PI NEWPORT
PA 686 CUSHING RD, NEWPORT, RI 02841 USA
SN 0028-1484
J9 NAV WAR COLL REV
JI Nav. War Coll. Rev.
PD FAL
PY 2015
VL 68
IS 4
BP 108
EP 113
PG 6
WC International Relations
SC International Relations
GA DP3ZW
UT WOS:000378436100008
ER
PT J
AU Edwards, LC
AF Edwards, L. Clifton
TI An Unlikely Retelling of the Incarnation Through Faerie and Pop Culture:
Ernest Saves Christmas
SO PRACTICAL THEOLOGY
LA English
DT Article
DE Christmas; Santa Claus; incarnation; nativity; fairy-story
AB A goofy Christmas flick makes an oblique reference to Christ, raising the question of what, if anything, Santa Claus, elves, and Christmas kitsch have to do with Christ's incarnation and nativity. I suggest that, through the vehicle of fairy-story, the film Ernest Saves Christmas, does, in fact, shed light on matters of belief, miracles, and morality - matters central to the incarnation. Even as told by Hollywood, Santa Claus is a fairy-story borrowing wonder and mystery from the Christ event itself.
C1 [Edwards, L. Clifton] US Army, Washington, DC USA.
RP Edwards, LC (reprint author), US Army, Washington, DC USA.
EM larry.c.edwards4.mil@mail.mil
NR 4
TC 0
Z9 0
U1 0
U2 0
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 1756-073X
EI 1756-0748
J9 PRACT THEOL
JI Pract. Theol.
PD SEP-DEC
PY 2015
VL 8
IS 3-4
BP 245
EP 249
DI 10.1080/1756073X.2015.1126005
PG 5
WC Religion
SC Religion
GA DL9AG
UT WOS:000375933000008
ER
PT J
AU Abdelzaher, AF
Mayo, ML
Perkins, EJ
Ghosh, P
AF Abdelzaher, Ahmed F.
Mayo, Michael L.
Perkins, Edward J.
Ghosh, Preetam
TI Contribution of canonical feed-forward loop motifs on the
fault-tolerance and information transport efficiency of transcriptional
regulatory networks
SO NANO COMMUNICATION NETWORKS
LA English
DT Article; Proceedings Paper
CT 8th International Conference on Bio-Inspired Information and
Communications Technologies (BICT)
CY DEC 01-03, 2014
CL Boston, MA
DE Shortest path; Centrality; Graph randomization; Clustering coefficient;
Feed-forward loop
ID SMALL-WORLD NETWORKS; COMPLEX NETWORKS; ATTACK TOLERANCE; ROBUSTNESS;
INTERNET; ERROR
AB Motifs and degree distribution in transcriptional regulatory networks play an important role towards their fault-tolerance and efficient information transport. In this paper, we designed an innovative in silico canonical feed-forward loop motif knockout experiment in the transcriptional regulatory network of E. coli to assess their impact on the following five topological features: average shortest path, diameter, closeness centrality, global and local clustering coefficients. Additional experiments were conducted to assess the effects of such motif abundance on E. coli's resilience to nodal failures and the end-to-end transmission delay. The purpose of this study is two-fold: (i) motivate the design of more accurate transcriptional network growing algorithms that can produce similar degree and motif distributions as observed in real biological networks and (ii) design more efficient bio-inspired wireless sensor network topologies that can inherit the robust information transport properties of biological networks.
Specifically, we observed that canonical feed forward loops demonstrate a strong negative correlation with the average shortest path, diameter and closeness centralities while they show a strong positive correlation with the average local clustering coefficient. Moreover, we observed that such motifs seem to be evenly distributed in the transcriptional regulatory network; however, the direct edges of multiple such motifs seem to be stitched together to facilitate shortest path based routing in such networks. Published by Elsevier B.V.
C1 [Abdelzaher, Ahmed F.; Ghosh, Preetam] Virginia Commonwealth Univ, Dept Comp Sci, Richmond, VA USA.
[Mayo, Michael L.; Perkins, Edward J.] US Army Engn Res & Dev Ctr, Environm Lab, Vicksburg, MS USA.
RP Ghosh, P (reprint author), Virginia Commonwealth Univ, Dept Comp Sci, Richmond, VA USA.
EM abdelzaheraf@vcu.edu; Michael.L.Mayo@usace.army.mil;
Edward.J.Perkins@usace.army.mil; pghosh@vcu.edu
FU US Army [W912HZ-14-P-0008]
FX This research was funded by the US Army's Environmental Quality and
Installations 6.1 basic research program, under contract
W912HZ-14-P-0008. Opinions, interpretations, conclusions, and
recommendations are those of the author(s) and are not necessarily
endorsed by the U.S. Army.
NR 46
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1878-7789
EI 1878-7797
J9 NANO COMMUN NETW
JI Nano Commun.Netw.
PD SEP
PY 2015
VL 6
IS 3
BP 133
EP 144
DI 10.1016/j.nancom.2015.04.002
PG 12
WC Engineering, Electrical & Electronic; Nanoscience & Nanotechnology;
Telecommunications
SC Engineering; Science & Technology - Other Topics; Telecommunications
GA DJ7SR
UT WOS:000374412900007
ER
PT J
AU Silton, SI
Fresconi, F
AF Silton, Sidra I.
Fresconi, Frank
TI Effect of Canard Interactions on Aerodynamic Performance of a
Fin-Stabilized Projectile
SO JOURNAL OF SPACECRAFT AND ROCKETS
LA English
DT Article
ID TRAILING VORTEX; MISSILE; ATTACK; ANGLE
AB This study was undertaken to better understand the impact of the canard trailing vortex flow interactions on the aerodynamic design and flight performance of short length-to-diameter, fin-stabilized munitions. Advanced computational aerodynamic and parameter sensitivity analysis techniques were applied. Results indicated that airframe designs that did not consider canard trailing vortex interactions on tail fins suffered from drastically underpredicted stability. Analyses were performed with the canard trailing-edge vortex-tail-fin interactions included to design a new airframe, and the suitability of this design was verified. The aerodynamics of the resulting configuration, as determined from advanced computational techniques, compared within 25% of the predictions (stability underpredicted) using scaled aerodynamic coefficients, suggesting that inclusion of scaled interference effects is a reasonable assumption during the design process.
C1 [Silton, Sidra I.] US Army, Res Lab, Flight Sci Branch, RDRL WML E, Aberdeen Proving Ground, MD 21005 USA.
[Fresconi, Frank] US Army, Res Lab, Precis Flight Dynam Team, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA.
RP Silton, SI (reprint author), US Army, Res Lab, Flight Sci Branch, RDRL WML E, Aberdeen Proving Ground, MD 21005 USA.
FU U.S. Department of Defense High Performance Computing Modernization
Program at the ARL DSRC (Aberdeen Proving Ground, Maryland)
FX This work was supported in part by a grant of high-performance computing
time from the U.S. Department of Defense High Performance Computing
Modernization Program at the ARL DSRC (Aberdeen Proving Ground,
Maryland). The authors would like to thank Ilmars Celmins for completing
the design modifications and creating the geometries in SolidWorks and
James DeSpirito for multiple discussions relating to the CFD
computations.
NR 21
TC 2
Z9 2
U1 3
U2 4
PU AMER INST AERONAUTICS ASTRONAUTICS
PI RESTON
PA 1801 ALEXANDER BELL DRIVE, STE 500, RESTON, VA 22091-4344 USA
SN 0022-4650
EI 1533-6794
J9 J SPACECRAFT ROCKETS
JI J. Spacecr. Rockets
PD SEP
PY 2015
VL 52
IS 5
BP 1430
EP 1442
DI 10.2514/1.A33219
PG 13
WC Engineering, Aerospace
SC Engineering
GA CS1RM
UT WOS:000361845400015
ER
PT J
AU Champagne, V
Nardi, A
Cote, D
AF Champagne, Victor
Nardi, Aaron
Cote, Danielle
TI MATERIALS CHARACTERIZATION OF ADVANCED COLD-SPRAY ALUMINUM ALLOYS
SO INTERNATIONAL JOURNAL OF POWDER METALLURGY
LA English
DT Article
ID POWDER PARTICLES; IMPACT; COATINGS; VELOCITY; TEXTURE
AB Cold spray is a powder consolidation process whereby metallic, polymeric, and/or combinations of metallic and non-metallic particles are consolidated to form a coating or a near-net-shaped-part by means of ballistic impingement upon a suitable substrate. To date the cold-spray process has been used primarily for dimensional restoration and to apply wear and corrosion, resistant coatings. However, advancements in the development of feedstock powders, process parameters, and cold-spray equipment have enabled the production of bulk cold-spray materials with superior properties, including increased strength and ductility comparable to those of wrought materials. The focus of this paper is to present materials characterization data of cold-spray aerospace aluminum alloys developed through collaborative research by the U.S. Army Research Laboratory, the United Technologies Research Center, and Worcester Polytechnic Institute that have been tested and qualified for use on military rotorcraft and fixed-wing aircraft.
C1 [Champagne, Victor] US Army Res Lab, Cold Spray Ctr, Proving Ground, MD 21005 USA.
[Nardi, Aaron] United Technol Res Ctr, Mech Met, E Hartford, CT 06108 USA.
[Cote, Danielle] Worcester Polytech Inst, Mat, Worcester, MA 01609 USA.
RP Champagne, V (reprint author), US Army Res Lab, Cold Spray Ctr, Proving Ground, MD 21005 USA.
EM vchampag@arl.army.mil
NR 27
TC 0
Z9 0
U1 5
U2 12
PU AMER POWDER METALLURGY INST
PI PRINCETON
PA 105 COLLEGE ROAD EAST, PRINCETON, NJ 08540 USA
SN 0888-7462
J9 INT J POWDER METALL
JI Int. J. Powder Metall.
PD FAL
PY 2015
VL 51
IS 4
BP 37
EP 47
PG 11
WC Metallurgy & Metallurgical Engineering
SC Metallurgy & Metallurgical Engineering
GA DD8YC
UT WOS:000370211800007
ER
PT J
AU Herzig, MC
McDaniel, J
Montgomery, R
Li, Y
Necsiou, C
Wendorff, D
Rathbone, C
Cancio, L
Batchinsky, A
Cap, AP
AF Herzig, M. C.
McDaniel, J.
Montgomery, R.
Li, Y.
Necsiou, C.
Wendorff, D.
Rathbone, C.
Cancio, L.
Batchinsky, A.
Cap, A. P.
TI Mesenchymal Stem Cells Show Pro-Coagulant Properties ex vivo
SO TRANSFUSION
LA English
DT Meeting Abstract
CT AABB Annual Meeting
CY OCT 24-27, 2015
CL Anaheim, CA
SP AABB
C1 [Herzig, M. C.; McDaniel, J.; Montgomery, R.; Li, Y.; Necsiou, C.; Wendorff, D.; Cancio, L.; Batchinsky, A.; Cap, A. P.] US Army Inst Surg Res, JBSA Ft Sam Houston, Ft Sam Houston, TX USA.
[Rathbone, C.] Arteriocyte, Hopkinton, MA USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0041-1132
EI 1537-2995
J9 TRANSFUSION
JI Transfusion
PD SEP
PY 2015
VL 55
SU 3
SI SI
MA SP20
BP 53A
EP 53A
PG 1
WC Hematology
SC Hematology
GA DD5GS
UT WOS:000369951500113
ER
PT J
AU Reddoch, K
Montgomery, R
Pidcoke, HF
Ramasubramanian, A
Cap, AP
AF Reddoch, K.
Montgomery, R.
Pidcoke, H. F.
Ramasubramanian, A.
Cap, A. P.
TI Mechanisms of Enhanced Thrombin Generation in Room-Temperature versus
Cold-Stored Platelets
SO TRANSFUSION
LA English
DT Meeting Abstract
CT AABB Annual Meeting
CY OCT 24-27, 2015
CL Anaheim, CA
SP AABB
C1 [Reddoch, K.; Ramasubramanian, A.] UTSA, San Antonio, TX USA.
[Montgomery, R.; Pidcoke, H. F.; Cap, A. P.] US Army Inst Surg Res, Ft Sam Houston, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0041-1132
EI 1537-2995
J9 TRANSFUSION
JI Transfusion
PD SEP
PY 2015
VL 55
SU 3
SI SI
BP 87A
EP 88A
PG 2
WC Hematology
SC Hematology
GA DD5GS
UT WOS:000369951500181
ER
PT J
AU Bynum, J
Meledeo, MA
Getz, T
Rodriquez, A
Pidcoke, HF
Cap, AP
AF Bynum, J.
Meledeo, M. A.
Getz, T.
Rodriquez, A.
Pidcoke, H. F.
Cap, A. P.
TI Platelet Additive Solution Improves Platelet Mitochondrial Function and
Reduces Reactive Oxygen Species in Stored Platelets
SO TRANSFUSION
LA English
DT Meeting Abstract
CT AABB Annual Meeting
CY OCT 24-27, 2015
CL Anaheim, CA
SP AABB
C1 [Bynum, J.; Meledeo, M. A.; Getz, T.; Rodriquez, A.; Pidcoke, H. F.; Cap, A. P.] US Army, San Antonio, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0041-1132
EI 1537-2995
J9 TRANSFUSION
JI Transfusion
PD SEP
PY 2015
VL 55
SU 3
SI SI
MA SP154
BP 114A
EP 114A
PG 1
WC Hematology
SC Hematology
GA DD5GS
UT WOS:000369951500244
ER
PT J
AU Parida, BK
Meyer, AD
McFaul, SJ
Cap, AP
AF Parida, B. K.
Meyer, A. D.
McFaul, S. J.
Cap, A. P.
TI Evaluation of Short-term Cold Storage of Platelet-poor Plasma for
Microvesicle Analysis by Flow Cytometry
SO TRANSFUSION
LA English
DT Meeting Abstract
CT AABB Annual Meeting
CY OCT 24-27, 2015
CL Anaheim, CA
SP AABB
C1 [Parida, B. K.; Meyer, A. D.; McFaul, S. J.; Cap, A. P.] US Army Inst Surg Res, Coagulat & Blood Resarch, San Antonio, TX USA.
[Meyer, A. D.] UT Hlth Sci Ctr San Antonio, Dept Pediat, San Antonio, TX USA.
NR 0
TC 0
Z9 0
U1 3
U2 3
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0041-1132
EI 1537-2995
J9 TRANSFUSION
JI Transfusion
PD SEP
PY 2015
VL 55
SU 3
SI SI
MA SP167
BP 120A
EP 120A
PG 1
WC Hematology
SC Hematology
GA DD5GS
UT WOS:000369951500257
ER
PT J
AU Wu, X
Benov, A
Darlington, D
Cap, AP
AF Wu, X.
Benov, A.
Darlington, D.
Cap, A. P.
TI The Effects of Tranexamic Acid on Trauma Induced Coagulopathy in Rats
SO TRANSFUSION
LA English
DT Meeting Abstract
CT AABB Annual Meeting
CY OCT 24-27, 2015
CL Anaheim, CA
SP AABB
C1 [Wu, X.; Benov, A.; Darlington, D.; Cap, A. P.] US Army Inst Surg Res, JBSA FT Sam Houston, Blood Program, Ft Sam Houston, TX USA.
[Wu, X.; Darlington, D.] Univ Texas Hlth Sci Ctr San Antonio, Surg, San Antonio, TX 78229 USA.
[Benov, A.] Israel Def Forces, Trauma & Combat Med Branch, Ramat Gan, Israel.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0041-1132
EI 1537-2995
J9 TRANSFUSION
JI Transfusion
PD SEP
PY 2015
VL 55
SU 3
SI SI
MA SP284
BP 170A
EP 171A
PG 2
WC Hematology
SC Hematology
GA DD5GS
UT WOS:000369951500374
ER
PT J
AU Manak, M
Mott, AM
Malia, J
Shutt, A
Njoku, O
Peel, S
AF Manak, M.
Mott, A. M.
Malia, J.
Shutt, A.
Njoku, O.
Peel, S.
TI Use of the MultiSpot in an HIV Screening Algorithm
SO TRANSFUSION
LA English
DT Meeting Abstract
CT AABB Annual Meeting
CY OCT 24-27, 2015
CL Anaheim, CA
SP AABB
C1 [Manak, M.; Shutt, A.] Henry Jackson Fdn MHRP, DLDM, Silver Spring, MD USA.
[Mott, A. M.; Malia, J.; Peel, S.] Walter Reed Army Inst Res, DLDM, Silver Spring, MD USA.
[Njoku, O.] Walter Reed Program, Abuja, Nigeria.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0041-1132
EI 1537-2995
J9 TRANSFUSION
JI Transfusion
PD SEP
PY 2015
VL 55
SU 3
SI SI
MA SP313
BP 184A
EP 185A
PG 2
WC Hematology
SC Hematology
GA DD5GS
UT WOS:000369951500403
ER
PT J
AU Yamashita, H
Valkeapaa, AI
Jayakumar, P
Sugiyama, H
AF Yamashita, Hiroki
Valkeapaa, Antti I.
Jayakumar, Paramsothy
Sugiyama, Hiroyuki
TI Continuum Mechanics Based Bilinear Shear Deformable Shell Element Using
Absolute Nodal Coordinate Formulation
SO JOURNAL OF COMPUTATIONAL AND NONLINEAR DYNAMICS
LA English
DT Article
ID OPTIMAL SOLID SHELLS; MULTILAYER COMPOSITES; NONLINEAR ANALYSES; PLATE;
STRAINS; EAS
AB In this investigation, a continuum mechanics based bilinear shear deformable shell element is developed using the absolute nodal coordinate formulation (ANCF) for the large deformation analysis of multibody shell structures. The element consists of four nodes, each of which has the global position coordinates and the transverse gradient coordinates along the thickness introduced for describing the orientation and deformation of the cross section of the shell element. The global position field on the middle surface and the position vector gradient at a material point in the element are interpolated by bilinear polynomials. The continuum mechanics approach is used to formulate the generalized elastic forces, allowing for the consideration of nonlinear constitutive models in a straightforward manner. The element lockings exhibited in the element are eliminated using the assumed natural strain (ANS) and enhanced assumed strain (EAS) approaches. In particular, the combined ANS and EAS approach is introduced to alleviate the thickness locking arising from the erroneous transverse normal strain distribution. Several numerical examples are presented in order to demonstrate the accuracy and the rate of convergence of numerical solutions obtained by the continuum mechanics based bilinear shear deformable ANCF shell element proposed in this investigation.
C1 [Yamashita, Hiroki] Univ Iowa, Dept Mech & Ind Engn, Seamans Ctr 2312, Iowa City, IA 52242 USA.
[Valkeapaa, Antti I.] Lappeenranta Univ Technol, Dept Mech Engn, Lappeenranta 53850, Finland.
[Jayakumar, Paramsothy] US Army RDECOM TARDEC, Warren, MI 48397 USA.
[Sugiyama, Hiroyuki] Univ Iowa, Dept Mech & Ind Engn, Seamans Ctr 2416C, Iowa City, IA 52242 USA.
RP Sugiyama, H (reprint author), Univ Iowa, Dept Mech & Ind Engn, Seamans Ctr 2416C, Iowa City, IA 52242 USA.
EM hiroyuki-sugiyama@uiowa.edu
FU Automotive Research Center (ARC); U.S. Army Tank Automotive Research,
Development and Engineering Center (TARDEC) [W56HZV-04-2-0001];
FunctionBay Inc.
FX This research was supported by the Automotive Research Center (ARC) in
accordance with Cooperative Agreement No. W56HZV-04-2-0001 U.S. Army
Tank Automotive Research, Development and Engineering Center (TARDEC).
Financial support for the last author received from FunctionBay Inc.,
was acknowledged.
NR 26
TC 4
Z9 4
U1 2
U2 5
PU ASME
PI NEW YORK
PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA
SN 1555-1423
EI 1555-1415
J9 J COMPUT NONLIN DYN
JI J. Comput. Nonlinear Dyn.
PD SEP
PY 2015
VL 10
IS 5
AR 051012
DI 10.1115/1.4028657
PG 9
WC Engineering, Mechanical; Mechanics
SC Engineering; Mechanics
GA DC2TW
UT WOS:000369070700013
ER
PT J
AU Moritz, H
White, K
Gouldby, B
Sweet, W
Ruggiero, P
Gravens, M
O'Brien, P
Moritz, H
Wahl, T
Nadal-Caraballo, NC
Veatch, W
AF Moritz, Heidi
White, Kate
Gouldby, Ben
Sweet, William
Ruggiero, Peter
Gravens, Mark
O'Brien, Patrick
Moritz, Hans
Wahl, Thomas
Nadal-Caraballo, Norberto C.
Veatch, Will
TI USACE adaptation approach for future coastal climate conditions
SO PROCEEDINGS OF THE INSTITUTION OF CIVIL ENGINEERS-MARITIME ENGINEERING
LA English
DT Article
DE coastal engineering; design methods & aids; risk & probability analysis
AB The US Army Corps of Engineers (USACE) is currently looking at variable temporal and geographic scales for total water level and event loading projections including storm description and characterisation relevant to project design and performance. USACE projects and event description must transition from engineering to planning to economics and project management. Capturing and articulating the appropriate level of uncertainty is important to a realistic projection of resultant risk. Close collaboration with national and international experts is an essential component in USACE's process of developing practical, nationally consistent, and cost-effective measures to reduce potential vulnerabilities resulting from global changes. The USACE's approach to developing guidance for evaluating and adapting to sea level change and total water level assessment are good examples of this collaboration. A primary focus at this time is the examination of methods and tools available at graduated levels of a project study. For project-level use, the USACE is defining specific assessments of components of total water level in addition to their varying impacts on project stability and performance. The required planning and risk assessment products for each performance type will be explained. The goal is to project adequately and cost-effectively future climate contributors that can result in various levels of project non-performance in a manner that will support effective long-term planning and project expenditures.
C1 [Moritz, Heidi; Moritz, Hans] USACE, Portland, OR 97221 USA.
[White, Kate] USACE, Climate Preparedness & Resilience Community Pract, Washington, DC USA.
[Gouldby, Ben] HR Wallingford, Wallingford, Oxon, England.
[Sweet, William] NOAA, Silver Spring, MD USA.
[Ruggiero, Peter] OSU, Corvallis, OR USA.
[Gravens, Mark; Veatch, Will] USACE, Vicksburg, MS USA.
[O'Brien, Patrick] USACE, San Francisco, CA USA.
[Wahl, Thomas] Univ S Florida, Tampa, FL USA.
[Wahl, Thomas] Univ Siegen, D-57068 Siegen, Germany.
[Veatch, Will] USACE, New Orleans, LA USA.
RP Moritz, H (reprint author), USACE, Portland, OR 97221 USA.
NR 6
TC 1
Z9 1
U1 3
U2 4
PU ICE PUBLISHING
PI WESTMINISTER
PA INST CIVIL ENGINEERS, 1 GREAT GEORGE ST, WESTMINISTER SW 1P 3AA, ENGLAND
SN 1741-7597
J9 P I CIVIL ENG-MAR EN
JI Proc. Inst. Civil. Eng.-Marit. Eng.
PD SEP
PY 2015
VL 168
IS 3
BP 111
EP 117
DI 10.1680/jmaen.15.00015
PG 7
WC Engineering, Civil; Engineering, Ocean; Water Resources
SC Engineering; Water Resources
GA DB3PM
UT WOS:000368423700003
ER
PT J
AU Lawson, SD
Wang, L
Fries, CA
Davis, M
AF Lawson, S. D.
Wang, L.
Fries, C. A.
Davis, M.
TI Hyperbaric Sub-normothermic ex-vivo Perfusion Delays the Onset of Acute
Rejection in a Porcine VCA Model
SO BRITISH JOURNAL OF SURGERY
LA English
DT Meeting Abstract
CT International Surgical Congress of the
Association-of-Surgeons-of-Great-Britain-and-Ireland
CY APR 22-24, 2015
CL Manchester, ENGLAND
SP Assoc Surg Great Britain & Ireland
C1 [Lawson, S. D.; Wang, L.; Davis, M.] US Army Inst Surg Res, San Antonio, TX USA.
[Fries, C. A.] USAISR Royal Ctr Def Med, Birmingham, W Midlands, England.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0007-1323
EI 1365-2168
J9 BRIT J SURG
JI Br. J. Surg.
PD SEP
PY 2015
VL 102
SU 7
SI SI
MA 1064
BP 182
EP 182
PG 1
WC Surgery
SC Surgery
GA DA9LN
UT WOS:000368130400619
ER
PT J
AU Lawson, SD
Wang, L
Fries, CA
Davis, M
AF Lawson, S. D.
Wang, L.
Fries, C. A.
Davis, M.
TI Hyperbaric Sub-normothermic ex-vivo Perfusion Delays the Onset of Acute
Rejection in a Porcine VCA Model
SO BRITISH JOURNAL OF SURGERY
LA English
DT Meeting Abstract
CT International Surgical Congress of the
Association-of-Surgeons-of-Great-Britain-and-Ireland
CY APR 22-24, 2015
CL Manchester, ENGLAND
SP Assoc Surg Great Britain & Ireland
C1 [Lawson, S. D.; Wang, L.; Davis, M.] US Army Inst Surg Res, San Antonio, TX USA.
[Fries, C. A.] Royal Ctr Def Med, USAISR, Birmingham, W Midlands, England.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0007-1323
EI 1365-2168
J9 BRIT J SURG
JI Br. J. Surg.
PD SEP
PY 2015
VL 102
SU 7
SI SI
MA 1064
BP 190
EP 190
PG 1
WC Surgery
SC Surgery
GA DA9LN
UT WOS:000368130400645
ER
PT J
AU Fries, CA
Lawson, SD
Wang, LC
Rickard, RF
Davis, MR
AF Fries, C. A.
Lawson, S. D.
Wang, L. C.
Rickard, R. F.
Davis, M. R.
TI Locally applied enzyme activated tacrolimus eluting hydrogels
significantly delay the onset of acute rejection of Vascularized
Composite Allotransplantation grafts
SO BRITISH JOURNAL OF SURGERY
LA English
DT Meeting Abstract
CT International Surgical Congress of the
Association-of-Surgeons-of-Great-Britain-and-Ireland
CY APR 22-24, 2015
CL Manchester, ENGLAND
SP Assoc Surg Great Britain & Ireland
C1 [Fries, C. A.; Lawson, S. D.; Wang, L. C.; Davis, M. R.] US Army Inst Surg Res, San Antonio, TX USA.
[Rickard, R. F.] Royal Ctr Def Med, San Antonio, TX USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0007-1323
EI 1365-2168
J9 BRIT J SURG
JI Br. J. Surg.
PD SEP
PY 2015
VL 102
SU 7
SI SI
MA 498
BP 196
EP 197
PG 2
WC Surgery
SC Surgery
GA DA9LN
UT WOS:000368130400666
ER
PT J
AU Lawson, SD
Wang, L
Fries, CA
Davis, M
AF Lawson, S. D.
Wang, L.
Fries, C. A.
Davis, M.
TI Hyperbaric Sub-Normothermic ex-vivo Perfusion Delays the Onset of Acute
Rejection in a Porcine VCA Model
SO BRITISH JOURNAL OF SURGERY
LA English
DT Meeting Abstract
CT International Surgical Congress of the
Association-of-Surgeons-of-Great-Britain-and-Ireland
CY APR 22-24, 2015
CL Manchester, ENGLAND
SP Assoc Surg Great Britain & Ireland
C1 [Lawson, S. D.; Wang, L.; Davis, M.] US Army Inst Surg Res, San Antonio, TX USA.
[Fries, C. A.] Royal Ctr Def Med, USAISR, Birmingham, W Midlands, England.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0007-1323
EI 1365-2168
J9 BRIT J SURG
JI Br. J. Surg.
PD SEP
PY 2015
VL 102
SU 7
SI SI
MA 1064
BP 200
EP 200
PG 1
WC Surgery
SC Surgery
GA DA9LN
UT WOS:000368130400678
ER
PT J
AU Coumbe, AT
AF Coumbe, Arthur T.
TI Bringing God to Men: American Military Chaplains and the Vietnam War
SO JOURNAL OF CHURCH AND STATE
LA English
DT Book Review
C1 [Coumbe, Arthur T.] US Mil Acad, West Point, NY 10996 USA.
RP Coumbe, AT (reprint author), US Mil Acad, West Point, NY 10996 USA.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0021-969X
EI 2040-4867
J9 J CHURCH STATE
JI J. Church State
PD FAL
PY 2015
VL 57
IS 4
BP 797
EP 799
DI 10.1093/jcs/csv096
PG 4
WC Religion
SC Religion
GA DB1MD
UT WOS:000368271400028
ER
PT J
AU Scaravilli, V
Kreyer, S
Linden, K
Belenkiy, S
Pesenti, A
Zanella, A
Cancio, LC
Batchinsky, AI
AF Scaravilli, Vittorio
Kreyer, Stefan
Linden, Katharina
Belenkiy, Slava
Pesenti, Antonio
Zanella, Alberto
Cancio, Leopoldo C.
Batchinsky, Andriy I.
TI Enhanced Extracorporeal CO2 Removal by Regional Blood Acidification:
Effect of Infusion of Three Metabolizable Acids
SO ASAIO JOURNAL
LA English
DT Article
DE extracorporeal circulation; carbon dioxide; lactic acid; citric acid;
acetic acid
ID CARBON-DIOXIDE REMOVAL; RENAL REPLACEMENT THERAPY; RESPIRATORY-FAILURE;
ACETATE METABOLISM; SODIUM-ACETATE; CITRATE; VENTILATION; LACTATE;
HUMANS; ANTICOAGULATION
AB Acidification of blood entering a membrane lung (ML) with lactic acid enhances CO2 removal (VCO2ML). We compared the effects of infusion of acetic, citric, and lactic acids on VCO2ML. Three sheep were connected to a custom-made circuit, consisting of a Hemolung device (Alung Technologies, Pittsburgh, PA), a hemofilter (NxStage, NxStage Medical, Lawrence, MA), and a peristaltic pump recirculating ultrafiltrate before the ML. Blood flow was set at 250 ml/min, gas flow (GF) at 10 L/min, and recirculating ultrafiltrate flow at 100 ml/min. Acetic (4.4 M), citric (0.4 M), or lactic (4.4 M) acids were infused in the ultrafiltrate at 1.5 mEq/min, for 2 hours each, in randomized fashion. VCO2ML was measured by the Hemolung built-in capnometer. Circuit and arterial blood gas samples were collected at baseline and during acid infusion. Hemodynamics and ventilation were monitored. Acetic, citric, or lactic acids similarly enhanced VCO2ML (+35%), from 37.4 +/- 3.6 to 50.6 +/- 7.4, 49.8 +/- 5.6, and 52.0 +/- 8.2 ml/min, respectively. Acids similarly decreased pH, increased pCO(2), and reduced HCO3- of the post-acid extracorporeal blood sample. No significant effects on arterial gas values, ventilation, or hemodynamics were observed. In conclusion, it is possible to increase VCO2ML by more than one-third using any one of the three metabolizable acids.
C1 [Scaravilli, Vittorio; Kreyer, Stefan; Linden, Katharina; Belenkiy, Slava; Cancio, Leopoldo C.; Batchinsky, Andriy I.] US Army Inst Surg Res, San Antonio, TX USA.
[Scaravilli, Vittorio; Pesenti, Antonio; Zanella, Alberto] Univ Milano Bicocca, Dipartimento Sci Salute, I-20052 Monza, MB, Italy.
[Kreyer, Stefan] Univ Hosp Bonn, Dept Anesthesiol & Intens Care Med, Bonn, Germany.
[Linden, Katharina] Univ Hosp Bonn, Dept Pediat, Bonn, Germany.
[Pesenti, Antonio] Osped San Gerardo, Dipartimento Anestesia & Rianimaz, Monza, MB, Italy.
RP Scaravilli, V (reprint author), Univ Milano Bicocca, Dipartimento Sci Salute, Via Cadore 48, I-20052 Monza, MB, Italy.
EM vittorio.scaravilli@gmail.com
FU US Army through the In-House Laboratory Independent Research Program at
the U.S. Army Institute of Surgical Research
FX Funding for this study was provided by the US Army through the In-House
Laboratory Independent Research Program at the U.S. Army Institute of
Surgical Research.
NR 38
TC 5
Z9 5
U1 2
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1058-2916
EI 1538-943X
J9 ASAIO J
JI Asaio J.
PD SEP-OCT
PY 2015
VL 61
IS 5
BP 533
EP 539
DI 10.1097/MAT.0000000000000238
PG 7
WC Engineering, Biomedical; Transplantation
SC Engineering; Transplantation
GA DA1GQ
UT WOS:000367544700009
PM 26273934
ER
PT J
AU Dietrich, CS
McClellan, ER
Whitcomb, BP
AF Dietrich, Charles S., III
McClellan, Edward R.
Whitcomb, Bradford P.
TI Lynch syndrome in the gynecologic population
SO TRANSLATIONAL GASTROINTESTINAL CANCER
LA English
DT Review
DE Endometrial cancer; Lynch syndrome (LS); ovarian cancer
ID COLORECTAL-CANCER SYNDROME; ENDOMETRIAL CANCER; OVARIAN-CANCER;
FAMILY-G; RISK; CARCINOMA; WOMEN; SURVEILLANCE; PREVENTION; STATEMENT
AB Lynch syndrome (LS) is caused by defects in mismatch repair genes and is inherited in an autosomal dominant fashion. The most common associated malignancies include colorectal cancer, endometrial cancer, and ovarian cancer. In females with LS, endometrial cancer is often the first identified malignancy, presenting gynecologists with an opportunity to intervene in order to prevent future cancers not only in the patient but also in family members. Universal testing of tumors using immunohistochemical techniques has emerged as a leading strategy to identify LS patients. In those found to have the syndrome, risk-reducing strategies including prophylactic hysterectomy and bilateral salpingo-oophorectomy are effective in preventing future gynecologic malignancies.
C1 [Dietrich, Charles S., III; McClellan, Edward R.; Whitcomb, Bradford P.] Tripler Army Med Ctr, Dept Obstet & Gynecol, Honolulu, HI 96859 USA.
RP Dietrich, CS (reprint author), Tripler Army Med Ctr, Dept Obstet & Gynecol, Gynecol Oncol Serv, 1 Jarrett White Rd, Honolulu, HI 96859 USA.
EM chuck.dietrich@us.army.mil
NR 24
TC 0
Z9 0
U1 1
U2 1
PU AME PUBL CO
PI SHEUNG WAN
PA ROOM 604 6-F HOLLYWOOD CENTER, 77-91, QUEENS ROAD, SHEUNG WAN, HONG KONG
00000, PEOPLES R CHINA
SN 2224-476X
EI 2224-4778
J9 TRANSL GASTROIN CANC
JI Transl. Gastrointestin. Cancer
PD SEP
PY 2015
VL 4
IS 5
BP 352
EP 358
DI 10.3978/j.issn.2224-4778.2015.09.03
PG 7
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA CY9RS
UT WOS:000366744600002
ER
PT J
AU Lin-Hurtubise, KM
Ishihara, K
McLaughlin, K
Morte, D
Sheffler, R
AF Lin-Hurtubise, Kevin M.
Ishihara, Kelli
McLaughlin, Keenan
Morte, Douglas
Sheffler, Robert
TI Lynch syndrome: expanded tumor spectrum, universal screening and
multimodal treatment strategies for colon cancer
SO TRANSLATIONAL GASTROINTESTINAL CANCER
LA English
DT Review
DE Lynch syndrome (LS); universal testing; 5-Fluorouracil chemotherapy
(5-FU chemotherapy); microsatellite instability (MSI); mismatch repair
(MMR); immunohistochemistry (IHC)
ID NONPOLYPOSIS COLORECTAL-CANCER; MISMATCH-REPAIR;
MICROSATELLITE-INSTABILITY; MUTATION CARRIERS; ADJUVANT THERAPY;
BLADDER-CANCER; RISK; SURVEILLANCE; STATISTICS; SURVIVAL
AB A total of 15% to 20% of colorectal cancers are considered familial and Lynch syndrome (LS) accounts for 2% to 6% of all cases. Recently, microsatellite instability (MSI) has been identified in breast, bladder and prostate cancers of Lynch mutation carriers, thus expanding the tumor spectrum. Potential Lynch patients can be initially screened by testing their cancer specimen for MSI and mismatch repair (MMR) gene with immunohistochemistry (IHC). If positive, then genetic testing of these individuals are strongly encouraged, in order to guide treatment such as extended colectomy plus 5-Fluorouracil (5-FU) based adjuvant chemotherapy particularly for Stage III Lynch colon cancer. With increased clinician awareness and improved identification of LS patients, surgical and chemo therapies can be tailored and optimized for their survival benefit.
C1 [Lin-Hurtubise, Kevin M.; Ishihara, Kelli] Tripler Army Med Ctr, Dept Surg, Honolulu, HI 96859 USA.
[McLaughlin, Keenan] Univ Iowa, Carver Coll Med, Iowa City, IA USA.
[Morte, Douglas] Uniformed Serv Univ Hlth Sci USUHS, Bethesda, MD USA.
[Sheffler, Robert] Tripler Army Med Ctr, Dept Med, Hematol & Oncol Serv, Honolulu, HI USA.
RP Lin-Hurtubise, KM (reprint author), Tripler Army Med Ctr, Dept Surg, Honolulu, HI 96859 USA.
EM kevin.m.linhurtubise.civ@mail.mil
NR 33
TC 0
Z9 0
U1 1
U2 1
PU AME PUBL CO
PI SHEUNG WAN
PA ROOM 604 6-F HOLLYWOOD CENTER, 77-91, QUEENS ROAD, SHEUNG WAN, HONG KONG
00000, PEOPLES R CHINA
SN 2224-476X
EI 2224-4778
J9 TRANSL GASTROIN CANC
JI Transl. Gastrointestin. Cancer
PD SEP
PY 2015
VL 4
IS 5
BP 367
EP 372
DI 10.3978/j.issn.2224-4778.2015.09.13
PG 6
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA CY9RS
UT WOS:000366744600004
ER
PT J
AU Johnson, D
Garcia-Blanco, J
Burgert, J
Fulton, L
Kadilak, P
Perry, K
Burke, J
AF Johnson, Don
Garcia-Blanco, Jose
Burgert, James
Fulton, Lawrence
Kadilak, Patrick
Perry, Katherine
Burke, Jeffrey
TI Effects of humeral intraosseous versus intravenous epinephrine on
pharmacokinetics and return of spontaneous circulation in a porcine
cardiac arrest model: A randomized control trial
SO ANNALS OF MEDICINE AND SURGERY
LA English
DT Article
DE Intraosseous; Return of spontaneous circulation; Epinephrine;
Pharmacokinetics; Resuscitation
ID EMERGENCY CARDIOVASCULAR CARE; AMERICAN-HEART-ASSOCIATION;
CARDIOPULMONARY-RESUSCITATION; VENTRICULAR-FIBRILLATION; VASCULAR
ACCESS; AMIODARONE
AB Cardiopulmonary Resuscitation (CPR), defibrillation, and epinephrine administration are pillars of advanced cardiac life support (ACLS). Intraosseous (IO) access is an alternative route for epinephrine administration when intravenous (IV) access is unobtainable. Previous studies indicate the pharmacokinetics of epinephrine administration via IO and IV routes differ, but it is not known if the difference influences return of spontaneous circulation (ROSC). The purpose of this prospective, experimental study was to determine the effects of humeral IO (HIO) and IV epinephrine administration during cardiac arrest on pharmacokinetics, ROSC, and odds of survival. Swine (N = 21) were randomized into 3 groups: humeral IO (HIO), peripheral IV (IV) and CPR/defibrillation control. Cardiac arrest was induced under general anesthesia. The swine remained in arrest for 2 min without intervention. Chest compressions were initiated and continued for 2 min. Epinephrine was administered and serial blood samples collected for pharmacokinetic analysis over 4 min. Defibrillation and epinephrine administration proceeded according to ACLS guidelines continuing for 20 min or until ROSC.
Seven HIO swine, 4 IV swine, and no control swine had ROSC. There were no significant differences in ROSC, maximum concentration; except at 30 s, and time-to-concentration-maximum between the HIO and IV groups. Significant differences existed between the experimental groups and the control. The HIO delivers a higher concentration of epinephrine than the IV route at 30 s which may be a survival advantage. Clinicians may consider using the IO route to administer epinephrine during CA when there is no preexisting IV access or when IV access is unobtainable. Published by Elsevier Ltd on behalf of IJS Publishing Group Limited. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
C1 [Johnson, Don; Burgert, James; Kadilak, Patrick; Perry, Katherine; Burke, Jeffrey] Northeastern Univ, US Army, Grad Program Anesthesia Nursing, Ft Sam Houston, TX 78234 USA.
[Johnson, Don; Garcia-Blanco, Jose; Burgert, James] Geneva Fdn, Tacoma, WA 98402 USA.
[Fulton, Lawrence] Texas Tech Univ, Rawls Coll Business, Dept Hlth Org Management, Lubbock, TX 79409 USA.
RP Johnson, D (reprint author), US Army, Med Dept & Sch, Acad Hlth Sci, 3490 Forage Rd,Suite 112, Ft Sam Houston, TX 78234 USA.
EM arthurjohnso@gmail.com
OI Burgert, James/0000-0001-8346-6196
NR 27
TC 6
Z9 6
U1 0
U2 2
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 2049-0801
J9 ANN MED SURG
JI Ann. Med. Surg.
PD SEP
PY 2015
VL 4
IS 3
BP 306
EP 310
DI 10.1016/j.amsu.2015.08.005
PG 5
WC Medicine, General & Internal
SC General & Internal Medicine
GA CY1XR
UT WOS:000366202100023
PM 26468375
ER
PT J
AU Brind, J
Condly, SJ
Mosher, SW
Morse, AR
Kimball, J
AF Brind, Joel
Condly, Steven J.
Mosher, Steven W.
Morse, Anne R.
Kimball, Jennifer
TI Risk of HIV Infection in Depot-Medroxyprogesterone Acetate (DMPA) Users:
A Systematic Review and Meta-Analysis
SO ISSUES IN LAW & MEDICINE
LA English
DT Article
ID HORMONAL CONTRACEPTIVE USE; SEXUALLY-TRANSMITTED INFECTIONS;
IMMUNODEFICIENCY-VIRUS TYPE-1; DAR-ES-SALAAM; NORTHERN THAILAND;
REPRODUCTIVE-AGE; SOUTH-AFRICA; WOMENS RISK; SEX WORKERS; ACQUISITION
AB Objective: As the HIV/AIDS epidemic continues to spread in Africa and Asia, use of the injectable contraceptive steroid DMPA is widespread and has been increasing. Since studies dating back to 1992 have suggested that DMPA may increase the transmission of HIV to women, we endeavored to determine if the extant epidemiological and biological evidence is sufficient to conclude that DMPA use constitutes a definite hazard to women's health.
Methods: We searched Medline using the search terms: contraceptives or contraception AND HIV and searched bibliographies of articles thus identified. We included in the meta-analysis all studies examining the association between use of DMPA (or injectable contraceptives comprising mostly DMPA) and the presence (cross-sectional studies, n = 8) or acquisition (longitudinal studies, n = 16) of HIV+ status in women, using a random effects models to estimate odds ratios (ORs; cross-sectional studies) and hazard ratios (HRs; longitudinal studies). Studies were excluded if the comparison group included women using any form of steroidal contraception.
Results: Statistically significant positive associations between DMPA use and HIV positivity were observed both in cross-sectional (OR = 1.41, 95% CI 1.15 - 1.73) and longitudinal studies (HR = 1.49, 95% CI 1.28 - 1.73). The biological plausibility of increased vulnerability to HIV infection due to progestational action (via thinning of the vaginal epithelial barrier and immunosuppression) as well as glucocorticoid agonistic immunosuppression, are discussed.
Conclusion: The epidemiological and biological evidence now make a compelling case that DMPA adds significantly to the risk of male-to-female HIV transmission.
C1 [Brind, Joel] CUNY, Baruch Coll, Dept Nat Sci, Biol & Endocrinol, New York, NY 10021 USA.
[Condly, Steven J.] United States Mil Acad, Off Econ Manpower Anal, West Point, NY USA.
[Mosher, Steven W.; Morse, Anne R.] Populat Res Inst, Front Royal, VA USA.
[Morse, Anne R.] Penn State Univ, Grad program Demog, University Pk, PA 16802 USA.
[Kimball, Jennifer] Ave Maria Sch Law, Bioeth, Naples, FL USA.
[Kimball, Jennifer] Culture Life Fdn, Washington, DC USA.
RP Brind, J (reprint author), CUNY, Baruch Coll, Dept Nat Sci, Biol & Endocrinol, New York, NY 10021 USA.
NR 46
TC 2
Z9 2
U1 1
U2 1
PU NATL LEGAL CENTER MEDICALLY DEPENDENT & DISABLED INC
PI INDIANAPOLIS
PA 50 S MERIDIAN STE 200, INDIANAPOLIS, IN 46204-3537 USA
SN 8756-8160
J9 ISSUES LAW MED
JI Issues Law Med.
PD FAL
PY 2015
VL 30
IS 2
BP 129
EP 139
PG 11
WC Law
SC Government & Law
GA CY2FQ
UT WOS:000366224600003
PM 26710371
ER
PT J
AU Loebel, A
Schooler, N
Siu, C
Cucchiaro, J
Pikalov, A
Goldman, R
Grossman, F
AF Loebel, A.
Schooler, N.
Siu, C.
Cucchiaro, J.
Pikalov, A.
Goldman, R.
Grossman, F.
TI Lurasidone treatment response in patients with schizophrenia assessed
using the DSM-5 dimensions of psychosis severity scale
SO EUROPEAN NEUROPSYCHOPHARMACOLOGY
LA English
DT Meeting Abstract
CT 28th Congress of the European-College-of-Neuropsychopharmacology (ECNP)
CY AUG 29-SEP 01, 2015
CL Amsterdam, NETHERLANDS
SP European Coll Neuropsychopharmacol
C1 [Schooler, N.] Suny Downstate Med Ctr, Psychiat, Brooklyn, NY 11203 USA.
[Siu, C.] COS & Associates Ltd, Data Sci, Hong Kong, Hong Kong, Peoples R China.
[Cucchiaro, J.] Sunov Pharmaceut Inc, Clin Operat, Ft Lee, VA USA.
[Pikalov, A.] Sunov Pharmaceut Inc, Med Affairs, Ft Lee, VA USA.
[Goldman, R.; Grossman, F.] Sunov Pharmaceut Inc, Res & Drug Dev, Ft Lee, VA USA.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0924-977X
EI 1873-7862
J9 EUR NEUROPSYCHOPHARM
JI Eur. Neuropsychopharmacol.
PD SEP
PY 2015
VL 25
SU 2
MA P.3.d.065
BP S518
EP S518
PG 1
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA CX2HS
UT WOS:000365518300193
ER
PT J
AU Neupane, S
Hong, HP
Giri, L
Karna, SP
Seifu, D
AF Neupane, Suman
Hong, Haiping
Giri, Lily
Karna, Shashi P.
Seifu, Dereje
TI Enhanced Magnetic Properties of Graphene Coated with Fe2O3 Nanoparticles
SO JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
LA English
DT Article
DE Graphene; Iron-Oxide; Nanocomposites; Vibrating Sample Magnetization;
Coercivity
ID CARBON NANOTUBES; FUNCTIONALIZED GRAPHENE; OXIDE; NANOCOMPOSITES;
NANOSHEETS; COMPOSITE; ELECTRODE; ANODE
AB Graphene, with its unique 2D nanostructure and excellent electrical, thermal, and mechanical properties, is considered an alternative to carbon nanotubes in nanocomposites. In this study, we present a one step approach for the deposition of iron oxide (Fe2O3) nanoparticles onto graphene sheets through solution mixture. The morphology, crystallinity, and magnetic properties of assynthesized composites were investigated. It was shown that highly crystalline Fe2O3 nanoparticles were densely and uniformly coated on graphene surface. Magnetic measurements reveal that, as compared to weak diamagnetism of pristine graphene, graphene-Fe2O3 nanocomposites display ferromagnetic behavior with coercivity of 101 Oe, saturation magnetization of 12.6 emu g(-1), and remanent magnetization of 3.13 emu g(-1) at room temperature. The enhanced magnetic performance was attributed to the homogeneous dispersion of Fe2O3 nanoparticles in graphene matrix and such nanocomposites are promising materials for applications in magnetic media and energy storage.
C1 [Neupane, Suman; Seifu, Dereje] Morgan State Univ, Dept Phys, Baltimore, MD 21251 USA.
[Hong, Haiping] South Dakota Sch Mines & Technol, Dept Mat & Met Engn, Rapid City, SD 57701 USA.
[Giri, Lily; Karna, Shashi P.] Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA.
RP Neupane, S (reprint author), Morgan State Univ, Dept Phys, Baltimore, MD 21251 USA.
FU ARL [W911NF-12-2-0041]; NSF [MRI-DMR-1337339]
FX One of the authors, Dereje Seifu, acknowledges funding from ARL
W911NF-12-2-0041 and from NSF MRI-DMR-1337339.
NR 30
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Z9 2
U1 9
U2 21
PU AMER SCIENTIFIC PUBLISHERS
PI VALENCIA
PA 26650 THE OLD RD, STE 208, VALENCIA, CA 91381-0751 USA
SN 1533-4880
EI 1533-4899
J9 J NANOSCI NANOTECHNO
JI J. Nanosci. Nanotechnol.
PD SEP
PY 2015
VL 15
IS 9
BP 6690
EP 6694
DI 10.1166/jnn.2015.10349
PG 5
WC Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; Materials
Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter
SC Chemistry; Science & Technology - Other Topics; Materials Science;
Physics
GA CX2VH
UT WOS:000365554400047
PM 26716229
ER
PT J
AU VanZomeren, CM
Reddy, KR
AF VanZomeren, Christine M.
Reddy, K. Ramesh
TI Use of a Modified Chemical Fractionation Scheme to Characterize Organic
Nitrogen in Wetland Soils
SO SOIL SCIENCE SOCIETY OF AMERICA JOURNAL
LA English
DT Article
ID DIFFUSION METHODS; INORGANIC-NITROGEN; FORMS; SEQUESTRATION; EXTRACTS;
WATER
AB Soil organic nitrogen (SON) is the main source of available N to microbes through mineralization. Although the importance of SON is recognized, the chemical nature of SON is not well described mainly because of methodological limitations. The objective of this study was to modify the operationally defined SON fractionation scheme to improve sample processing time. The operationally defined SON pools are amino sugar N, amino acid N, and hydrolyzable unknown N. Modifications to the method included: SON hydrolysis using an electric griddle, use of 0.05 mol L-1 H2SO4 NH3 traps, and use of a forced-air oven during amino acid N deamination. The modified method improved sample throughput by (i) increasing soil extractions from one to 12 samples at a time, (ii) decreasing sample analysis time by using colorimetric methods, and (iii) reducing temperature variability during amino acid N deamination. We estimate that the method modifications save on average 5 h per 12 samples. The modified method was then applied to 10 flooded or drained wetland soils that ranged from 3 to 34 g kg(-1) total N (TN). The labile SON pools ranged from 0.06 to 1.29 g kg(-1) amino sugar N and 0.74 to 10.5 g kg(-1) amino acid N. Amino sugar N linearly increased with soil total C (TC; R-2 = 0.60). Amino acid N exponentially increased with TC (R-2 = 0.80), suggesting that conditions in wetlands preferentially conserve amino acid N. A decline in amino acid N with drained conditions highlighted the potential loss of TN stored in wetlands, estimated at 50 to 75 Pg.
C1 [VanZomeren, Christine M.; Reddy, K. Ramesh] Univ Florida, Wetland Biogeochem Lab, Dept Soil & Water Sci, Gainesville, FL 32611 USA.
RP VanZomeren, CM (reprint author), US Army, Engineer Res & Dev Ctr, Corps Engineers, Vicksburg, MS 39180 USA.
EM christine.m.vanzomeren@usace.army.mil
FU National Science Foundation [DEB-0841596]
FX This study was funded by the National Science Foundation (DEB-0841596).
We would like to thank Yu Wang and F. Gavin Wilson for laboratory
assistance, Dr. Richard Mulvaney for providing helpful suggestions
during the initial method setup, and Dr. Alan Wright and Dr. John White
for providing comments that improved this paper. In addition, we would
like to thank two anonymous reviewers for providing comments that
significantly improved the quality of this paper.
NR 26
TC 0
Z9 0
U1 1
U2 9
PU SOIL SCI SOC AMER
PI MADISON
PA 677 SOUTH SEGOE ROAD, MADISON, WI 53711 USA
SN 0361-5995
EI 1435-0661
J9 SOIL SCI SOC AM J
JI Soil Sci. Soc. Am. J.
PD SEP-OCT
PY 2015
VL 79
IS 5
BP 1509
EP 1517
DI 10.2136/sssaj2015.05.0178
PG 9
WC Soil Science
SC Agriculture
GA CX0PM
UT WOS:000365399100023
ER
PT J
AU Hibberd, EE
Shutt, CE
Oyama, S
Blackburn, JT
Myers, JB
AF Hibberd, Elizabeth E.
Shutt, Casey E.
Oyama, Sakiko
Blackburn, J. Troy
Myers, Joseph B.
TI Physical contributors to glenohumeral internal rotation deficit in high
school baseball players
SO JOURNAL OF SPORT AND HEALTH SCIENCE
LA English
DT Article
DE Baseball; GIRD; Humeral retrotorsion; Muscle stiffness; Posterior
capsule thickness
ID POSTERIOR SHOULDER TIGHTNESS; HUMERAL-RETROTORSION; COLLEGIATE BASEBALL;
THROWING SHOULDER; MOTION DEFICITS; UPPER EXTREMITY; RANGE; PITCHERS;
RETROVERSION; IMPINGEMENT
AB Background: Glenohumeral internal rotation deficit (GIRD) is a risk factor for shoulder and elbow injury in baseball players. Although this evidence forms a basis for recommending stretching, clinical measures of internal rotation range of motion (ROM) do not differentiate if GIRD is due to muscular, capsuloligamentous, or osseous factors. Understanding the contributions of these structures to GIRD is important for the development of targeted interventions. We hypothesize that the osseous component will have the greatest relative contribution to GIRD, followed by muscle stiffness and posterior capsule thickness.
Methods: Internal rotation ROM, muscle stiffness (teres minor, infraspinatus, and posterior deltoid), posterior capsule thickness, and humeral retrotorsion were evaluated on 156 baseball players. A side-to-side difference was calculated for each variable. Variables were entered into a multivariable linear regression to determine the significant predictors of GIRD.
Results: The regression model was statistically significant (R-2 = 0.134, F(1, 156) = 24.0, p < 0.01) with only humeral retrotorsion difference remaining as a significant predictor (beta = -0.243, t(156) = -4.9, p < 0.01). A greater humeral retrotorsion side-to-side difference was associated with more GIRD.
Conclusion: Humeral retrotorsion accounted for 13.3% of the variance in GIRD. The stiffness of the superficial shoulder muscles and capsular thickness, as measured in this study, were not predictors of GIRD. Factors not assessed in this study, such as deeper muscle stiffness, capsule/ligament laxity, and neuromuscular regulation of muscle stiffness may also contribute to GIRD. Since it is the largest contributor to GIRD, causes of changes in humeral retrotorsion need to be identified. The osseous component only accounted for 13.3% of the variance in GIRD, indicating a large contribution from soft tissues factors that were not addressed in this study. These factors need to be identified to develop evidence-based evaluations and intervention programs to decrease the risk of injury in baseball players. Copyright (C) 2014, Shanghai University of Sport. Production and hosting by Elsevier B.V. All rights reserved.
C1 [Hibberd, Elizabeth E.] Univ Alabama, Dept Hlth Sci, Tuscaloosa, AL 35487 USA.
[Shutt, Casey E.] US Army Baylor Univ, San Antonio, TX 78234 USA.
[Oyama, Sakiko] Univ Texas San Antonio, Dept Hlth & Kinesiol, San Antonio, TX 78249 USA.
[Blackburn, J. Troy] Univ N Carolina, Dept Exercise & Sport Sci, Neuromuscular Res Lab, Chapel Hill, NC 27599 USA.
[Myers, Joseph B.] Univ N Carolina, Dept Exercise & Sport Sci, Sports Med Res Labs, Chapel Hill, NC 27599 USA.
RP Hibberd, EE (reprint author), Univ Alabama, Dept Hlth Sci, Tuscaloosa, AL 35487 USA.
EM eehibberd@ches.ua.edu
NR 50
TC 0
Z9 0
U1 1
U2 2
PU SHANGHAI UNIV SPORT
PI SHANGHAI
PA EDITORIAL BOARD, 650 QINGYUANHUAN RD, SHANGHAI, 200438, PEOPLES R CHINA
SN 2095-2546
EI 2213-2961
J9 J SPORT HEALTH SCI
JI J. Sport Health Sci.
PD SEP
PY 2015
VL 4
IS 3
BP 299
EP 306
DI 10.1016/j.jshs.2014.04.008
PG 8
WC Hospitality, Leisure, Sport & Tourism; Sport Sciences
SC Social Sciences - Other Topics; Sport Sciences
GA CW9YD
UT WOS:000365353200013
ER
PT J
AU Terrill, WA
AF Terrill, W. Andrew
TI The Unraveling: High Hopes and Missed Opportunities in Iraq
SO MIDDLE EAST JOURNAL
LA English
DT Book Review
C1 [Terrill, W. Andrew] US Army War Coll, Strateg Studies Inst, Carlisle, PA 17013 USA.
RP Terrill, WA (reprint author), US Army War Coll, Strateg Studies Inst, Carlisle, PA 17013 USA.
NR 1
TC 0
Z9 0
U1 1
U2 1
PU MIDDLE EAST INST
PI WASHINGTON
PA 1761 N ST NW, CIRCULATION DEPT, WASHINGTON, DC 20036-2882 USA
SN 0026-3141
EI 1940-3461
J9 MIDDLE EAST J
JI Middle East J.
PD FAL
PY 2015
VL 69
IS 4
BP 635
EP 636
PG 2
WC Area Studies
SC Area Studies
GA CW8XB
UT WOS:000365281600013
ER
PT J
AU Zuhur, S
Tadros, M
AF Zuhur, Sherifa
Tadros, Marlyn
TI EGYPT'S CONSPIRACY DISCOURSE: LIBERALS, COPTS AND ISLAMISTS
SO MIDDLE EAST POLICY
LA English
DT Article
C1 [Zuhur, Sherifa] US Army War Coll, Natl Secur, Strateg Studies Inst, Carlisle, PA USA.
[Tadros, Marlyn] Northeastern Univ, Middle East Ctr, Boston, MA USA.
[Tadros, Marlyn] Arts Inst New England, Web Dev & Interact Media, Brookline, MA USA.
RP Zuhur, S (reprint author), Univ Calif Berkeley, Ctr Middle Eastern Studies, Berkeley, CA 94720 USA.
NR 36
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1061-1924
EI 1475-4967
J9 MIDDLE EAST POLICY
JI Middle East Policy
PD FAL
PY 2015
VL 22
IS 3
BP 109
EP 126
DI 10.1111/mepo.12147
PG 18
WC Area Studies; International Relations
SC Area Studies; International Relations
GA CV9ZU
UT WOS:000364649100009
ER
PT J
AU Niece, KL
Boyd, NK
Akers, KS
AF Niece, Krista L.
Boyd, Natalie K.
Akers, Kevin S.
TI In Vitro Study of the Variable Effects of Proton Pump Inhibitors on
Voriconazole
SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
LA English
DT Article
ID INVASIVE FUNGAL-INFECTIONS; PLASMA-CONCENTRATIONS; DRUG-INTERACTIONS;
IMMUNOCOMPROMISED CHILDREN; CYTOCHROME-P450 ENZYMES; PERSONALIZED
MEDICINE; CYP2C19 GENOTYPE; PHARMACOKINETICS; EFFICACY; SAFETY
AB Voriconazole is a broad-spectrum antifungal agent used for the treatment of severe fungal infections. Maintaining therapeutic concentrations of 1 to 5.5 mu g/ml is currently recommended to maximize the exposure-response relationship of voriconazole. However, this is challenging, given the highly variable pharmacokinetics of the drug, which includes metabolism by cytochrome P450 (CYP450) isotypes CYP2C19, CYP3A4, and CYP2C9, through which common metabolic pathways for many medications take place and which are also expressed in different isoforms with various metabolic efficacies. Proton pump inhibitors (PPIs) are also metabolized through these enzymes, making them competitive inhibitors of voriconazole metabolism, and coadministration with voriconazole has been reported to increase total voriconazole exposure. We examined the effects of five PPIs (rabeprazole, pantoprazole, lansoprazole, omeprazole, and esomeprazole) on voriconazole concentrations using four sets of human liver microsomes (HLMs) of different CYP450 phenotypes. Overall, the use of voriconazole in combination with any PPI led to a significantly higher voriconazole yield compared to that achieved with voriconazole alone in both pooled HLMs (77% versus 59%; P < 0.001) and individual HLMs (86% versus 76%; P < 0.001). The mean percent change in the voriconazole yield from that at the baseline after PPI exposure in pooled microsomes ranged from 22% with pantoprazole to 51% with esomeprazole. Future studies are warranted to confirm whether and how the deliberate coadministration of voriconazole and PPIs can be used to boost voriconazole levels in patients with difficult-to-treat fungal infections.
C1 [Niece, Krista L.; Akers, Kevin S.] US Army, Dept Extrem Trauma & Regenerat Med, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
[Boyd, Natalie K.] Univ Texas Austin, Coll Pharm, Austin, TX 78712 USA.
[Boyd, Natalie K.] Univ Texas Hlth Sci Ctr San Antonio, Pharmacotherapy Educ & Res Ctr, San Antonio, TX 78229 USA.
[Akers, Kevin S.] San Antonio Mil Med Ctr, Infect Dis Serv, Dept Med, Jbsa Ft Sam Houston, TX USA.
RP Akers, KS (reprint author), US Army, Dept Extrem Trauma & Regenerat Med, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
EM kevin.s.akers.mil@mail.mil
FU Military Infectious Disease Research Program (MIDRP)
[D_MIDCTA_I_12_J2_299]
FX This work was supported by funding from the Military Infectious Disease
Research Program (MIDRP), award no. D_MIDCTA_I_12_J2_299.
NR 60
TC 2
Z9 2
U1 0
U2 0
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0066-4804
EI 1098-6596
J9 ANTIMICROB AGENTS CH
JI Antimicrob. Agents Chemother.
PD SEP
PY 2015
VL 59
IS 9
BP 5548
EP 5554
DI 10.1128/AAC.00884-15
PG 7
WC Microbiology; Pharmacology & Pharmacy
SC Microbiology; Pharmacology & Pharmacy
GA CV5XD
UT WOS:000364343900057
PM 26124167
ER
PT J
AU Pramukkul, P
Svenkeson, A
West, BJ
Grigolini, P
AF Pramukkul, Pensri
Svenkeson, Adam
West, Bruce J.
Grigolini, Paolo
TI The value of conflict in stable social networks
SO EPL
LA English
DT Article
ID DYNAMICS; INFORMATION
AB A cooperative network model of sociological interest is examined to determine the sensitivity of the global dynamics to having a fraction of the members behaving uncooperatively, that is, being in conflict with the majority. We study a condition where in the absence of these uncooperative individuals, the contrarians, the control parameter exceeds a critical value and the network is frozen in a state of consensus. The network dynamics change with variations in the percentage of contrarians, resulting in a balance between the value of the control parameter and the percentage of those in conflict with the majority. We show that, as a finite-size effect, the transmission of information from a network B to a network A, with a small fraction of lookout members in A who adopt the behavior of B, becomes maximal when both networks are assigned the same critical percentage of contrarians. Copyright (C) EPLA, 2015
C1 [Pramukkul, Pensri; Svenkeson, Adam; Grigolini, Paolo] Univ N Texas, Ctr Nonlinear Sci, Denton, TX 76203 USA.
[Pramukkul, Pensri] Chiang Mai Rajabhat Univ, Fac Sci & Technol, Chiang Mai 50300, Thailand.
[Svenkeson, Adam] Army Res Lab, Adelphi, MD 20783 USA.
[West, Bruce J.] Army Res Off, Informat Sci Directorate, Res Triangle Pk, NC 27709 USA.
RP Pramukkul, P (reprint author), Univ N Texas, Ctr Nonlinear Sci, POB 311427, Denton, TX 76203 USA.
FU ARO [W911NF-15-1-0245]; Welch [B-1577]
FX PP, AS, and PG warmly thank ARO and Welch for their support through
Grants No. W911NF-15-1-0245 and No. B-1577, respectively.
NR 36
TC 3
Z9 3
U1 0
U2 0
PU EPL ASSOCIATION, EUROPEAN PHYSICAL SOCIETY
PI MULHOUSE
PA 6 RUE DES FRERES LUMIERE, MULHOUSE, 68200, FRANCE
SN 0295-5075
EI 1286-4854
J9 EPL-EUROPHYS LETT
JI EPL
PD SEP
PY 2015
VL 111
IS 5
AR 58003
DI 10.1209/0295-5075/111/58003
PG 6
WC Physics, Multidisciplinary
SC Physics
GA CV8LO
UT WOS:000364539100036
ER
PT J
AU Sweeney, LM
Phillips, EA
Goodwin, MR
Bannon, DI
AF Sweeney, Lisa M.
Phillips, Elizabeth A.
Goodwin, Michelle R.
Bannon, Desmond I.
TI Toxicokinetic Model Development for the Insensitive Munitions Component
3-Nitro-1,2,4-Triazol-5-One
SO INTERNATIONAL JOURNAL OF TOXICOLOGY
LA English
DT Article
DE 3-nitro-1,2,4-triazol-5-one; insensitive munitions; toxicokinetics;
physiologically based pharmacokinetic (PBPK) model
ID RAT-LIVER MICROSOMES; PARTITION-COEFFICIENTS; C-14-LABELED
5-NITRO-1,2,4-TRIAZOL-3-ONE; PHARMACOKINETIC MODELS; ORGANIC-CHEMICALS;
CARDIAC OUTPUT; MONKEY; METABOLISM; ALGORITHM; NTO
AB 3-Nitro-1,2,4-triazol-5-one (NTO) is a component of insensitive munitions that are potential replacements for conventional explosives. Toxicokinetic data can aid in the interpretation of toxicity studies and interspecies extrapolation, but only limited data on the toxicokinetics and metabolism of NTO are available. To supplement these limited data, further in vivo studies of NTO in rats were conducted and blood concentrations were measured, tissue distribution of NTO was estimated using an in silico method, and physiologically based pharmacokinetic models of the disposition of NTO in rats and macaques were developed and extrapolated to humans. The model predictions can be used to extrapolate from designated points of departure identified from rat toxicology studies to provide a scientific basis for estimates of acceptable human exposure levels for NTO.
C1 [Sweeney, Lisa M.] Henry M Jackson Fdn Adv Mil Med, NAMRU D, Wright Patterson AFB, OH 45433 USA.
[Phillips, Elizabeth A.; Goodwin, Michelle R.] CAMRIS, NAMRU D, Wright Patterson AFB, OH USA.
[Bannon, Desmond I.] US Army, Publ Hlth Command, Inst Publ Hlth Toxicol Portfolio, Aberdeen Proving Ground, MD USA.
RP Sweeney, LM (reprint author), Henry M Jackson Fdn Adv Mil Med, NAMRU D, Wright Patterson AFB, OH 45433 USA.
EM lisa.sweeney.3.ctr@us.af.mil
FU US Army Environmental Quality Technology, Ordnance Environmental Program
through the Army Research, Development, Engineering Command,
Environmental Sustainment Acquisition and Logistics Program; Army
Institute of Public Health, Toxicology Portfolio
FX The author(s) disclosed receipt of the following financial support for
the research, authorship, and/or publication of this article: This work
was funded by the US Army Environmental Quality Technology, Ordnance
Environmental Program through the Army Research, Development,
Engineering Command, Environmental Sustainment Acquisition and Logistics
Program through coordination with the Army Institute of Public Health,
Toxicology Portfolio, and conducted under work unit number H1263.
NR 30
TC 0
Z9 0
U1 2
U2 11
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1091-5818
EI 1092-874X
J9 INT J TOXICOL
JI Int. J. Toxicol.
PD SEP-OCT
PY 2015
VL 34
IS 5
BP 408
EP 416
DI 10.1177/1091581815589000
PG 9
WC Pharmacology & Pharmacy; Toxicology
SC Pharmacology & Pharmacy; Toxicology
GA CV0YF
UT WOS:000363979100004
PM 26060267
ER
PT J
AU Sweeney, LM
Goodwin, MR
Hulgan, AD
Gut, CP
Bannon, DI
AF Sweeney, Lisa M.
Goodwin, Michelle R.
Hulgan, Angela D.
Gut, Chester P., Jr.
Bannon, Desmond I.
TI Toxicokinetic Model Development for the Insensitive Munitions Component
2,4-Dinitroanisole
SO INTERNATIONAL JOURNAL OF TOXICOLOGY
LA English
DT Article
DE 2, 4-dinitroanisole; 2, 4-dinitrophenol; insensitive munitions;
toxicokinetics; physiologically based pharmacokinetic (PBPK) model
ID PARTITION-COEFFICIENTS; PHARMACOKINETIC MODELS; ORGANIC-CHEMICALS;
CARDIAC OUTPUT; RAT-LIVER; IN-VITRO; METABOLISM; ALGORITHM; MONKEYS;
TISSUES
AB The Armed Forces are developing new explosives that are less susceptible to unintentional detonation (insensitive munitions [IMX]). 2,4-Dinitroanisole (DNAN) is a component of IMX. Toxicokinetic data for DNAN are required to support interpretation of toxicology studies and refinement of dose estimates for human risk assessment. Male Sprague-Dawley rats were dosed by gavage (5, 20, or 80 mg DNAN/kg), and blood and tissue samples were analyzed to determine the levels of DNAN and its metabolite 2,4-dinitrophenol (DNP). These data and data from the literature were used to develop preliminary physiologically based pharmacokinetic (PBPK) models. The model simulations indicated saturable metabolism of DNAN in rats at higher tested doses. The PBPK model was extrapolated to estimate the toxicokinetics of DNAN and DNP in humans, allowing the estimation of human-equivalent no-effect levels of DNAN exposure from no-observed adverse effect levels determined in laboratory animals, which may guide the selection of exposure limits for DNAN.
C1 [Sweeney, Lisa M.] Henry M Jackson Fdn Adv Mil Med, NAMRUD, Wright Patterson AFB, OH 45433 USA.
[Goodwin, Michelle R.; Gut, Chester P., Jr.] CAMRIS, NAMRUD, Wright Patterson AFB, OH USA.
[Hulgan, Angela D.] Oak Ridge Inst Sci & Educ, NAMRUD, Wright Patterson AFB, OH USA.
[Bannon, Desmond I.] US Army, Publ Hlth Command, Inst Publ Hlth Toxicol Portfolio, Aberdeen Proving Ground, MD USA.
RP Sweeney, LM (reprint author), Henry M Jackson Fdn Adv Mil Med, NAMRUD, 2729 R St,Area B Bldg 837, Wright Patterson AFB, OH 45433 USA.
EM lisa.sweeney.3.ctr@us.af.mil
FU US Army Environmental Quality Technology, Ordnance Environmental Program
through the Army Research, Development, Engineering Command,
Environmental Sustainment Acquisition and Logistics Program; Army
Institute of Public Health, Toxicology Portfolio
FX The author(s) disclosed receipt of the following financial support for
the research, authorship, and/or publication of this article: This work
was funded by the US Army Environmental Quality Technology, Ordnance
Environmental Program through the Army Research, Development,
Engineering Command, Environmental Sustainment Acquisition and Logistics
Program through coordination with the Army Institute of Public Health,
Toxicology Portfolio and conducted under work unit number (WUN) H1263.
NR 34
TC 0
Z9 0
U1 2
U2 9
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1091-5818
EI 1092-874X
J9 INT J TOXICOL
JI Int. J. Toxicol.
PD SEP-OCT
PY 2015
VL 34
IS 5
BP 417
EP 432
DI 10.1177/1091581815594623
PG 16
WC Pharmacology & Pharmacy; Toxicology
SC Pharmacology & Pharmacy; Toxicology
GA CV0YF
UT WOS:000363979100005
PM 26173616
ER
PT J
AU Angelini, DJ
Moyer, RA
Cole, S
Willis, KL
Oyler, J
Dorsey, RM
Salem, H
AF Angelini, Daniel J.
Moyer, Robert A.
Cole, Stephanie
Willis, Kristen L.
Oyler, Jonathan
Dorsey, Russell M.
Salem, Harry
TI The Pesticide Metabolites Paraoxon and Malaoxon Induce Cellular Death by
Different Mechanisms in Cultured Human Pulmonary Cells
SO INTERNATIONAL JOURNAL OF TOXICOLOGY
LA English
DT Article
DE apoptosis; caspase; malaoxon; necrosis; organophosphates; paraoxon;
pulmonary toxicity
ID MICROINSTILLATION INHALATION EXPOSURE; AIRWAY EPITHELIAL-CELLS; NERVE
AGENT VX; GUINEA-PIGS; ORGANOPHOSPHORUS INSECTICIDES; RESPIRATORY
TOXICITY; LUNG; APOPTOSIS; PARATHION; SOMAN
AB Organophosphorus (OP) pesticides are known to induce pulmonary toxicity in both humans and experimental animals. To elucidate the mechanism of OP-induced cytotoxicity, we examined the effects of parathion and malathion and their respective metabolites, paraoxon and malaoxon, on primary cultured human large and small airway cells. Exposure to paraoxon and malaoxon produced a dose-dependent increase in cytotoxicity following a 24-hour exposure, while treatment with parathion or malathion produced no effects at clinically relevant concentrations. Exposure to paraoxon-induced caspase activation, but malaoxon failed to induce this response. Since caspases have a major role in the regulation of apoptosis and cell death, we evaluated OP-induced cell death in the presence of a caspase inhibitor. Pharmacological caspase inhibition protected against paraoxon-induced cell death but not malaoxon-induced cell death. These data suggest that caspase activation is a key signaling element in paraoxon-induced cell death, but not malaoxon-induced cellular death in the pulmonary epithelium.
C1 [Angelini, Daniel J.; Cole, Stephanie; Willis, Kristen L.] CNR, Res Associates Program, Washington, DC 20418 USA.
[Angelini, Daniel J.; Cole, Stephanie] Excet Inc, Springfield, VA USA.
[Moyer, Robert A.; Cole, Stephanie; Willis, Kristen L.] Def Threat Reduct Agcy, Chem & Biol Technol Dept, Ft Belvoir, VA USA.
[Moyer, Robert A.] Battelle Mem Inst, Columbus, OH 43201 USA.
[Oyler, Jonathan] US Army, Med Res Inst Chem Def, Med Command, Aberdeen Proving Ground, MD USA.
[Dorsey, Russell M.; Salem, Harry] US Army, Res Dev & Engn Command, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD USA.
[Salem, Harry] Chem Secur Assessment Ctr, Dept Homeland Secur, Aberdeen Proving Ground, MD USA.
RP Angelini, DJ (reprint author), Excet Inc, 5183 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA.
EM daniel.j.angelini2.ctr@mail.mil
FU U.S. Army Edgewood Chemical Biological Center's Commander's Fund
FX The author(s) disclosed receipt of the following financial support for
the research, authorship, and/or publication of this article: This work
was supported through the U.S. Army Edgewood Chemical Biological
Center's Commander's Fund.
NR 39
TC 0
Z9 0
U1 3
U2 6
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1091-5818
EI 1092-874X
J9 INT J TOXICOL
JI Int. J. Toxicol.
PD SEP-OCT
PY 2015
VL 34
IS 5
BP 433
EP 441
DI 10.1177/1091581815593933
PG 9
WC Pharmacology & Pharmacy; Toxicology
SC Pharmacology & Pharmacy; Toxicology
GA CV0YF
UT WOS:000363979100006
PM 26173615
ER
PT J
AU Sun, HL
Cunningham, FL
Harris, J
Xu, YF
Long, LP
Hanson-Dorr, K
Baroch, JA
Fioranelli, P
Lutman, MW
Li, T
Pedersen, K
Schmit, BS
Cooley, J
Lin, XX
Jarman, RG
DeLiberto, TJ
Wan, XF
AF Sun, Hailiang
Cunningham, Fred L.
Harris, Jillian
Xu, Yifei
Long, Li-Ping
Hanson-Dorr, Katie
Baroch, John A.
Fioranelli, Paul
Lutman, Mark W.
Li, Tao
Pedersen, Kerri
Schmit, Brandon S.
Cooley, Jim
Lin, Xiaoxu
Jarman, Richard G.
DeLiberto, Thomas J.
Wan, Xiu-Feng
TI Dynamics of virus shedding and antibody responses in influenza A
virus-infected feral swine
SO JOURNAL OF GENERAL VIROLOGY
LA English
DT Article
ID VIRAL-RNA REPLICATION; UNITED-STATES; PACKAGING SIGNALS; PIGS; H5N1;
TRANSMISSION; MICE; PATHOGENICITY; CHINA; AMPLIFICATION
AB Given their free-ranging habits, feral swine could serve as reservoirs or spatially dynamic 'mixing vessels' for influenza A virus (IAV). To better understand virus shedding patterns and antibody response dynamics in the context of IAV surveillance amongst feral swine, we used IAV of feral swine origin to perform infection experiments. The virus was highly infectious and transmissible in feral swine, and virus shedding patterns and antibody response dynamics were similar to those in domestic swine. In the virus-inoculated and sentinel groups, virus shedding lasted <= 6 and <= 9 days, respectively. Antibody titres in inoculated swine peaked at 1 : 840 on day 11 post-inoculation (p.i.), remained there until 21 days p.i. and dropped to <1 : 220 at 42 days p.i. Genomic sequencing identified changes in wildtype (WT) viruses and isolates from sentinel swine, most notably an amino acid divergence in nucleoprotein position 473. Using data from cell culture as a benchmark, sensitivity and specificity of a matrix gene-based quantitative reverse transcription-PCR method using nasal swab samples for detection of IAV in feral swine were 78.9 and 78.1 %, respectively. Using data from haemagglutination inhibition assays as a benchmark, sensitivity and specificity of an ELISA for detection of IAV-specific antibody were 95.4 and 95.0 %, respectively. Serological surveillance from 2009 to 2014 showed that similar to 7.58 % of feral swine in the USA were positive for IAV. Our findings confirm the susceptibility of IAV infection and the high transmission ability of IAV amongst feral swine, and also suggest the need for continued surveillance of IAVs in feral swine populations.
C1 [Sun, Hailiang; Harris, Jillian; Xu, Yifei; Long, Li-Ping; Wan, Xiu-Feng] Mississippi State Univ, Coll Vet Med, Dept Basic Sci, Mississippi State, MS 39762 USA.
[Cunningham, Fred L.; Hanson-Dorr, Katie; Fioranelli, Paul] Anim & Plant Hlth Inspect Serv, Mississippi Field Stn, Natl Wildlife Res Ctr, Wildlife Serv,USDA, Mississippi State, MS USA.
[Baroch, John A.; Schmit, Brandon S.; DeLiberto, Thomas J.] US Anim & Plant Hlth Inspect Serv, Natl Wildlife Res Ctr, Wildlife Serv, USDA, Ft Collins, CO USA.
[Lutman, Mark W.; Pedersen, Kerri] US Anim & Plant Hlth Inspect Serv, USDA, Wildlife Serv, Ft Collins, CO USA.
[Li, Tao; Lin, Xiaoxu; Jarman, Richard G.] Walter Reed Army Inst Res, Viral Dis Branch, Silver Spring, MD USA.
[Cooley, Jim] Mississippi State Univ, Coll Vet Med, Dept Pathobiol & Populat Med, Mississippi State, MS 39762 USA.
RP Wan, XF (reprint author), Mississippi State Univ, Coll Vet Med, Dept Basic Sci, Mississippi State, MS 39762 USA.
EM wan@cvm.msstate.edu
OI Hanson-Dorr, Katie/0000-0003-4559-938X
FU Wildlife Services, National Wildlife Research Center, US Department of
Agriculture [13-7428-0961-CA, 14-7428-1041-CA]; National Institutes of
Health [P20GM103646]; Global Emerging Infection Systems, a Division of
the Armed Forces Health Surveillance Center
FX This work was supported by the Wildlife Services, National Wildlife
Research Center, US Department of Agriculture (13-7428-0961-CA and
14-7428-1041-CA), and partially funded by the National Institutes of
Health (P20GM103646). Funding for virus sequencing was supported by the
Global Emerging Infection Systems, a Division of the Armed Forces Health
Surveillance Center. The opinions or assertions contained herein are the
private views of the authors and are not to be construed as reflecting
the official views of the US Army or the US Department of Defense.
NR 56
TC 2
Z9 2
U1 0
U2 2
PU SOC GENERAL MICROBIOLOGY
PI READING
PA MARLBOROUGH HOUSE, BASINGSTOKE RD, SPENCERS WOODS, READING RG7 1AG,
BERKS, ENGLAND
SN 0022-1317
EI 1465-2099
J9 J GEN VIROL
JI J. Gen. Virol.
PD SEP
PY 2015
VL 96
BP 2569
EP 2578
DI 10.1099/jgv.0.000225
PN 9
PG 10
WC Biotechnology & Applied Microbiology; Virology
SC Biotechnology & Applied Microbiology; Virology
GA CV0CQ
UT WOS:000363915400009
PM 26297148
ER
PT J
AU LaPorte, GJ
Branke, J
Chen, CH
AF LaPorte, G. Jake
Branke, Juergen
Chen, Chun-Hung
TI Adaptive Parent Population Sizing in Evolution Strategies
SO EVOLUTIONARY COMPUTATION
LA English
DT Article
DE Evolution strategy; parental population size; adaptive population sizing
ID GENETIC ALGORITHMS; SIZE; LAMBDA)-THEORY; RECOMBINATION; CHOICE
AB Adaptive population sizing aims at improving the overall progress of an evolution strategy. At each generation, it determines the parental population size that promises the largest fitness gain, based on the information collected during the evolutionary process. In this paper, we develop an adaptive variant of a ( mu/ mu lambda) evolution strategy. Based on considerations on the sphere, we derive two approaches for adaptive population sizing. We then test these approaches empirically on the sphere model using a normalized mutation strength and cumulative mutation strength adaption. Finally, we compare the methodology on more general functions with a fixed population, covariance matrix adaption evolution strategy ( CMA- ES). The results confirm that our adaptive population sizing methods yield better results than even the best fixed population size.
C1 [LaPorte, G. Jake] US Mil Acad, Dept Math Sci, West Point, NY 10996 USA.
[Branke, Juergen] Univ Warwick, Warwick Business Sch, Coventry CV4 7AL, W Midlands, England.
[Chen, Chun-Hung] George Mason Univ, Dept Syst Engn & Operat Res, Fairfax, VA 22030 USA.
RP LaPorte, GJ (reprint author), US Mil Acad, Dept Math Sci, West Point, NY 10996 USA.
EM jake.laporte@usma.edu; juergen.branke@wbs.ac.uk; cchen9@gmu.edu
FU National Science Foundation [CMMI-1233376]; Department of Energy
[DE-SC0002223]; NIH [1R21DK088368-01]; National Science Council of
Taiwan [NSC-100-2218-E-002-027-MY3]
FX This work has been supported in part by National Science Foundation
under Award CMMI-1233376, Department of Energy under Award DE-SC0002223,
NIH under Grant 1R21DK088368-01, and National Science Council of Taiwan
under Award NSC-100-2218-E-002-027-MY3.
NR 24
TC 1
Z9 1
U1 0
U2 1
PU MIT PRESS
PI CAMBRIDGE
PA ONE ROGERS ST, CAMBRIDGE, MA 02142-1209 USA
SN 1063-6560
EI 1530-9304
J9 EVOL COMPUT
JI Evol. Comput.
PD FAL
PY 2015
VL 23
IS 3
BP 397
EP 420
DI 10.1162/EVCO_a_00136
PG 24
WC Computer Science, Artificial Intelligence; Computer Science, Theory &
Methods
SC Computer Science
GA CT5HG
UT WOS:000362839000003
PM 25110912
ER
PT J
AU Katlein, C
Arndt, S
Nicolaus, M
Perovich, DK
Jakuba, MV
Suman, S
Elliott, S
Whitcomb, LL
McFarland, CJ
Gerdes, R
Boetius, A
German, CR
AF Katlein, Christian
Arndt, Stefanie
Nicolaus, Marcel
Perovich, Donald K.
Jakuba, Michael V.
Suman, Stefano
Elliott, Stephen
Whitcomb, Louis L.
McFarland, Christopher J.
Gerdes, Ruediger
Boetius, Antje
German, Christopher R.
TI Influence of ice thickness and surface properties on light transmission
through Arctic sea ice
SO JOURNAL OF GEOPHYSICAL RESEARCH-OCEANS
LA English
DT Article
DE melt ponds; light transmittance; albedo; ROV; spatial variability;
shortwave radiation
ID OPTICAL-PROPERTIES; COVER; MELT; VARIABILITY; ALBEDO; BUDGET
AB The observed changes in physical properties of sea ice such as decreased thickness and increased melt pond cover severely impact the energy budget of Arctic sea ice. Increased light transmission leads to increased deposition of solar energy in the upper ocean and thus plays a crucial role for amount and timing of sea-ice-melt and under-ice primary production. Recent developments in underwater technology provide new opportunities to study light transmission below the largely inaccessible underside of sea ice. We measured spectral under-ice radiance and irradiance using the new Nereid Under-Ice (NUI) underwater robotic vehicle, during a cruise of the R/V Polarstern to 83 degrees N 6 degrees W in the Arctic Ocean in July 2014. NUI is a next generation hybrid remotely operated vehicle (H-ROV) designed for both remotely piloted and autonomous surveys underneath land-fast and moving sea ice. Here we present results from one of the first comprehensive scientific dives of NUI employing its interdisciplinary sensor suite. We combine under-ice optical measurements with three dimensional under-ice topography (multibeam sonar) and aerial images of the surface conditions. We investigate the influence of spatially varying ice-thickness and surface properties on the spatial variability of light transmittance during summer. Our results show that surface properties such as melt ponds dominate the spatial distribution of the under-ice light field on small scales (<1000 m(2)), while sea ice-thickness is the most important predictor for light transmission on larger scales. In addition, we propose the use of an algorithm to obtain histograms of light transmission from distributions of sea ice thickness and surface albedo.
C1 [Katlein, Christian; Arndt, Stefanie; Nicolaus, Marcel; Gerdes, Ruediger; Boetius, Antje] Alfred Wegener Inst, Helmholtz Zentrum Polar & Meeresforsch, Bremerhaven, Germany.
[Katlein, Christian; Gerdes, Ruediger] Jacobs Univ Bremen, D-28759 Bremen, Germany.
[Perovich, Donald K.] Cold Reg Res & Engn Lab, Hanover, NH USA.
[Jakuba, Michael V.; Suman, Stefano; Elliott, Stephen; Whitcomb, Louis L.; German, Christopher R.] Woods Hole Oceanog Inst, Deep Submergence Lab, Woods Hole, MA USA.
[Whitcomb, Louis L.; McFarland, Christopher J.] Johns Hopkins Univ, Dept Mech Engn, Baltimore, MD 21218 USA.
[Boetius, Antje] Max Planck Inst Marine Microbiol, Bremen, Germany.
RP Katlein, C (reprint author), Alfred Wegener Inst, Helmholtz Zentrum Polar & Meeresforsch, Bremerhaven, Germany.
EM Christian.Katlein@awi.de
RI Boetius, Antje/D-5459-2013;
OI Boetius, Antje/0000-0003-2117-4176; Arndt, Stefanie/0000-0001-9782-3844;
Katlein, Christian/0000-0003-2422-0414
FU U.S. National Science Foundation Office of Polar Programs (NSF OPP)
[ANT-1126311]; National Oceanic and Atmospheric Administration Office of
Exploration and Research (NOAA OER) [NA14OAR4320158]; Woods Hole
Oceanographic Institution; James Family Foundation; George Frederick
Jewett Foundation East; graduate school Polmar; European Research
Council [294757]; Alfred-Wegener-Institut Helmholtz-Zentrum fur Polar-
und Meeresforschung
FX We gratefully acknowledge the support of the Captain and Crew of R/V
Polarstern expedition PS86. Nereid-UI development and at-sea operations
were supported by the U.S. National Science Foundation Office of Polar
Programs (NSF OPP ANT-1126311), National Oceanic and Atmospheric
Administration Office of Exploration and Research (NOAA OER
NA14OAR4320158), the Woods Hole Oceanographic Institution, the James
Family Foundation, the George Frederick Jewett Foundation East. We thank
Martin Steffens for providing the aerial images and the graduate school
Polmar for granting an outgoing scholarship which supported the writing
of this manuscript. We thank Samuel Laney for comments improving this
manuscript. Additional funds supporting this work were provided to Antje
Boetius by the European Research Council Advanced Investigator grant
294757. Optical data are available at
http://dx.doi.org/10.1594/PANGAEA.846130 all vehicle related data are
available from the Woods Hole Oceanographic Institution
(mjakuba@whoi.edu). This study was funded by the Alfred-Wegener-Institut
Helmholtz-Zentrum fur Polar- und Meeresforschung.
NR 49
TC 8
Z9 8
U1 3
U2 22
PU AMER GEOPHYSICAL UNION
PI WASHINGTON
PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA
SN 2169-9275
EI 2169-9291
J9 J GEOPHYS RES-OCEANS
JI J. Geophys. Res.-Oceans
PD SEP
PY 2015
VL 120
IS 9
BP 5932
EP 5944
DI 10.1002/2015JC010914
PG 13
WC Oceanography
SC Oceanography
GA CU4BF
UT WOS:000363470300003
PM 27660738
ER
PT J
AU Webster, MA
Rigor, IG
Perovich, DK
Richter-Menge, JA
Polashenski, CM
Light, B
AF Webster, Melinda A.
Rigor, Ignatius G.
Perovich, Donald K.
Richter-Menge, Jacqueline A.
Polashenski, Christopher M.
Light, Bonnie
TI Seasonal evolution of melt ponds on Arctic sea ice
SO JOURNAL OF GEOPHYSICAL RESEARCH-OCEANS
LA English
DT Article
DE sea ice; melt ponds
ID MASS-BALANCE; SNOW COVER; SUMMER; VARIABILITY; MORPHOLOGY; SHEBA
AB The seasonal evolution of melt ponds has been well documented on multiyear and landfast first-year sea ice, but is critically lacking on drifting, first-year sea ice, which is becoming increasingly prevalent in the Arctic. Using 1 m resolution panchromatic satellite imagery paired with airborne and in situ data, we evaluated melt pond evolution for an entire melt season on drifting first-year and multiyear sea ice near the 2011 Applied Physics Laboratory Ice Station (APLIS) site in the Beaufort and Chukchi seas. A new algorithm was developed to classify the imagery into sea ice, thin ice, melt pond, and open water classes on two contrasting ice types: first-year and multiyear sea ice. Surprisingly, melt ponds formed approximate to 3 weeks earlier on multiyear ice. Both ice types had comparable mean snow depths, but multiyear ice had 0-5 cm deep snow covering approximate to 37% of its surveyed area, which may have facilitated earlier melt due to its low surface albedo compared to thicker snow. Maximum pond fractions were 533% and 383% on first-year and multiyear ice, respectively. APLIS pond fractions were compared with those from the Surface Heat Budget of the Arctic Ocean (SHEBA) field campaign. APLIS exhibited earlier melt and double the maximum pond fraction, which was in part due to the greater presence of thin snow and first-year ice at APLIS. These results reveal considerable differences in pond formation between ice types, and underscore the importance of snow depth distributions in the timing and progression of melt pond formation.
C1 [Webster, Melinda A.; Rigor, Ignatius G.; Light, Bonnie] Univ Washington, Appl Phys Lab, Polar Sci Ctr, Seattle, WA 98195 USA.
[Perovich, Donald K.; Richter-Menge, Jacqueline A.; Polashenski, Christopher M.] US Army Corps Engn, Engn Res & Dev Ctr, Cold Reg Res & Engn Lab, Hanover, NH USA.
[Perovich, Donald K.] Dartmouth Coll, Thayer Sch Engn, Hanover, NH 03755 USA.
RP Webster, MA (reprint author), Univ Washington, Appl Phys Lab, Polar Sci Ctr, Seattle, WA 98195 USA.
EM melindaw@uw.edu
FU NASA
FX NTM images are available at: http://gfl.usgs.gov/. The NASA OIB/NRL
DISTANCE in situ snow and ice thickness data are available at:
http://nsidc.org/data/icebridge/icex2011-icecamp.html. ATM data are
available at: http://nsidc.org/data/ilatm1b. DMS images are available
at: http://nsidc.org/data/iodms1b. IMB buoy data are available at:
http://imb.erdc.dren.mil/buoysum.htm. This research was supported by
NASA and other contributors to the U.S. Interagency Arctic Buoy Program.
The authors would like to thank the Forum for Arctic Modeling and
Observational Synthesis (FAMOS) group for the helpful discussions and
Earl Wilson, Joe Adams, Beverly Friesen, Suzanne Noble, Wendy Ermold,
Sinead Farrell, and Thomas Newman for their assistance with data and
useful comments.
NR 46
TC 9
Z9 9
U1 6
U2 16
PU AMER GEOPHYSICAL UNION
PI WASHINGTON
PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA
SN 2169-9275
EI 2169-9291
J9 J GEOPHYS RES-OCEANS
JI J. Geophys. Res.-Oceans
PD SEP
PY 2015
VL 120
IS 9
BP 5968
EP 5982
DI 10.1002/2015JC011030
PG 15
WC Oceanography
SC Oceanography
GA CU4BF
UT WOS:000363470300005
ER
PT J
AU Hunsawong, T
Sunintaboon, P
Warit, S
Thaisomboonsuk, B
Jarman, RG
Yoon, IK
Ubol, S
Fernandez, S
AF Hunsawong, Taweewun
Sunintaboon, Panya
Warit, Saradee
Thaisomboonsuk, Butsaya
Jarman, Richard G.
Yoon, In-Kyu
Ubol, Sukathida
Fernandez, Stefan
TI Immunogenic Properties of a BCG Adjuvanted Chitosan Nanoparticle-Based
Dengue Vaccine in Human Dendritic Cells
SO PLOS NEGLECTED TROPICAL DISEASES
LA English
DT Article
ID BACILLUS-CALMETTE-GUERIN; IMMUNE-RESPONSE; HUMORAL RESPONSES; VIRUS;
ANTIGEN; MICE; DELIVERY; IDENTIFICATION; IMMUNIZATION; STRATEGIES
AB Dengue viruses (DENVs) are among the most rapidly and efficiently spreading arboviruses. WHO recently estimated that about half of the world's population is now at risk for DENV infection. There is no specific treatment or vaccine available to treat or prevent DENV infections. Here, we report the development of a novel dengue nanovaccine (DNV) composed of UV-inactivated DENV-2 (UVI-DENV) and Mycobacterium bovis Bacillus Calmette-Guerin cell wall components (BCG-CWCs) loaded into chitosan nanoparticles (CS-NPs). CS-NPs were prepared by an emulsion polymerization method prior to loading of the BCG-CWCs and UVI-DENV components. Using a scanning electron microscope and a zetasizer, DNV was determined to be of spherical shape with a diameter of 372.0 +/- 11.2 nm in average and cationic surface properties. The loading efficacies of BCG-CWCs and UVI-DENV into the CS-NPs and BCG-CS-NPs were up to 97.2 and 98.4%, respectively. THP-1 cellular uptake of UVI-DENV present in the DNV was higher than soluble UVI-DENV alone. DNV stimulation of immature dendritic cells (iDCs) resulted in a significantly higher expression of DCs maturation markers (CD80, CD86 and HLA-DR) and induction of various cytokine and chemokine productions than in UVI-DENV-treated iDCs, suggesting a potential use of BCG-CS-NPs as adjuvant and delivery system for dengue vaccines.
C1 [Hunsawong, Taweewun; Thaisomboonsuk, Butsaya; Yoon, In-Kyu] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand.
[Hunsawong, Taweewun; Ubol, Sukathida] Mahidol Univ, Fac Sci, Dept Microbiol, Bangkok 10400, Thailand.
[Sunintaboon, Panya] Mahidol Univ, Fac Sci, Dept Chem, Bangkok 10400, Thailand.
[Warit, Saradee] Natl Sci & Technol Dev Agcy, Natl Ctr Genet Engn & Biotechnol, TB Res Lab, Pathum Thani, Thailand.
[Jarman, Richard G.] Walter Reed Army Inst Res, Viral Dis Branch, Bethesda, MD USA.
[Fernandez, Stefan] US Army Med Mat Dev Act, Ft Detrick, MD USA.
RP Hunsawong, T (reprint author), Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand.
EM sukathida.ubo@mahidol.ac.th; stefan.fernandez.mil@mail.mil
FU Military Infectious Disease Research Program (MIDRP) [S0453_14_AF]
FX This work was funded by the Military Infectious Disease Research Program
(MIDRP) grant S0453_14_AF. The funders had no role in study design, data
collection and analysis, decision to publish, or preparation of the
manuscript.
NR 36
TC 2
Z9 2
U1 2
U2 14
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1935-2735
J9 PLOS NEGLECT TROP D
JI Plos Neglect. Trop. Dis.
PD SEP
PY 2015
VL 9
IS 9
AR e0003958
DI 10.1371/journal.pntd.0003958
PG 18
WC Infectious Diseases; Parasitology; Tropical Medicine
SC Infectious Diseases; Parasitology; Tropical Medicine
GA CT7YI
UT WOS:000363031200010
PM 26394138
ER
PT J
AU Perliger, A
AF Perliger, Arie
TI Comparative Framework for Understanding Jewish and Christian Violent
Fundamentalism
SO RELIGIONS
LA English
DT Article
DE terrorism; Christian Identity; Religious-Zionism; Israel; religious
movements
AB Although most scholars agree that in the last couple of decades, religious fundamentalism has become the dominant ideological feature in the landscape of modern terrorism, many prefer to ignore the fact that this is not a development which is restricted to the Islamic world, and that other religious traditions have also experienced growth in groups which prefer to use violent strategies to promote their sacred visions. The current chapter strives to fill this gap by analyzing the emergence of violent religious groups in two distinct, non-Islamic, religious traditions. At first glance, the Christian Identity and the Religious-Zionist movements have very little in common. However, both movements served as a breeding ground for the emergence of violent fundamentalist groups aspiring to facilitate an apocalyptic/redemption scenario by engaging in illegal violent campaigns. Moreover, in both cases, the role of spiritual leaders was crucial in shaping the radicalization of the groups and their target selection, and the violence had a clear symbolic narrative. In other words, for the members of these violent groups, the violence served a clear role in the mobilization of potential supporters, and the branding and dissemination of the movement's ideology. Finally, while in general, terrorism is perceived as the weapon of the weak, in these two cases it was perpetrated by individuals/groups affiliated to communities belonging to the dominant religious framework in their respective polities (i.e., the Religious-Zionist and Christian Identity movements are perceived by their members as branches of Judaism and Christianity). Hence, by utilizing a comparative framework, the article will not just analyze the violent manifestations that emerged from these two movements, but also try to identify the unique factors that characterize and facilitate the emergence of religious groups within religious communities belonging to the dominant religious tradition in their societies.
C1 US Mil Acad, Dept Social Sci, West Point, NY 10996 USA.
RP Perliger, A (reprint author), US Mil Acad, Dept Social Sci, 607 Cullum Rd,Lincoln Hall,Rm 120, West Point, NY 10996 USA.
EM arie.perliger@usma.edu
RI Coomann, Benjamin/G-2465-2016
NR 27
TC 0
Z9 0
U1 0
U2 4
PU MDPI AG
PI BASEL
PA POSTFACH, CH-4005 BASEL, SWITZERLAND
SN 2077-1444
J9 RELIGIONS
JI Religions
PD SEP
PY 2015
VL 6
IS 3
BP 1033
EP 1047
DI 10.3390/rel6031033
PG 15
WC Religion
SC Religion
GA CT2OZ
UT WOS:000362643700018
ER
PT J
AU Wei, XL
Back, C
Izhvanov, O
Khasanov, OL
Haines, CD
Olevsky, EA
AF Wei, Xialu
Back, Christina
Izhvanov, Oleg
Khasanov, Oleg L.
Haines, Christopher D.
Olevsky, Eugene A.
TI Spark Plasma Sintering of Commercial Zirconium Carbide Powders:
Densification Behavior and Mechanical Properties
SO MATERIALS
LA English
DT Article
DE zirconium carbide (ZrC); spark plasma sintering (SPS); power-law creep
(PLC); transverse rupture strength (TRS); microhardness (H-v)
ID STEADY-STATE CREEP; POWER-LAW CREEP; FUNDAMENTAL-ASPECTS; DISLOCATION
CLIMB; CONSOLIDATION; CERAMICS; PRESSURE; KINETICS; SCALABILITY;
COMPOSITES
AB Commercial zirconium carbide (ZrC) powder is consolidated by Spark Plasma Sintering (SPS). Processing temperatures range from 1650 to 2100 degrees C. Specimens with various density levels are obtained when performing single-die SPS at different temperatures. Besides the single-die tooling setup, a double-die tooling setup is employed to largely increase the actual applied pressure to achieve higher densification in a shorter processing time. In order to describe the densification mechanism of ZrC powder under SPS conditions, a power-law creep constitutive equation is utilized, whose coefficients are determined by the inverse regression of the obtained experimental data. The densification of the selected ZrC powder is shown to be likely associated with grain boundary sliding and dislocation glide controlled creep. Transverse rupture strength and microhardness of sintered specimens are measured to be up to 380 MPa and 24 GPa, respectively. Mechanical properties are correlated with specimens' average grain size and relative density to elucidate the co-factor dependencies.
C1 [Wei, Xialu; Olevsky, Eugene A.] San Diego State Univ, Dept Mech Engn, Coll Engn, San Diego, CA 92182 USA.
[Back, Christina; Izhvanov, Oleg] Gen Atom, San Diego, CA 92121 USA.
[Khasanov, Oleg L.; Olevsky, Eugene A.] Natl Res Tomsk Polytech Univ, Tomsk 634650, Russia.
[Haines, Christopher D.] US Army, Armament Res Dev Engn Ctr, Picatinny Arsenal, NJ 07806 USA.
RP Olevsky, EA (reprint author), San Diego State Univ, Dept Mech Engn, Coll Engn, 5500 Campanile Dr, San Diego, CA 92182 USA.
EM xwei@mail.sdsu.edu; tina.back@ga.com; oleg.izhvanov@ga.com;
khasanov@tpu.ru; christopher.d.haines2.civ@mail.mil;
eolevsky@mail.sdsu.edu
FU US Department of Energy, Materials Sciences Division [DE-SC0008581]
FX The support of the US Department of Energy, Materials Sciences Division,
under Award No. DE-SC0008581 is gratefully acknowledged.
NR 52
TC 6
Z9 6
U1 6
U2 23
PU MDPI AG
PI BASEL
PA POSTFACH, CH-4005 BASEL, SWITZERLAND
SN 1996-1944
J9 MATERIALS
JI Materials
PD SEP
PY 2015
VL 8
IS 9
BP 6043
EP 6061
DI 10.3390/ma8095289
PG 19
WC Materials Science, Multidisciplinary
SC Materials Science
GA CT2NM
UT WOS:000362639200028
ER
PT J
AU Cheppudira, BP
Garza, TH
Petz, LN
Clifford, JL
Fowler, M
AF Cheppudira, Bopaiah P.
Garza, Thomas H.
Petz, Lawrence N.
Clifford, John L.
Fowler, Marcie
TI Anti-hyperalgesic effects of AG490, a Janus kinase inhibitor, in a rat
model of inflammatory pain
SO BIOMEDICAL REPORTS
LA English
DT Article
DE inflammatory pain; Janus kinase 2 inhibitor; AG490; thermal
hyperalgesia; mechanical hyperalgesia
ID INTERLEUKIN-6; INVOLVEMENT; EXPRESSION; RECEPTORS; ARTHRITIS; INJURY
AB Interleukin 6 (IL-6) has a critical role in pain mechanisms. IL-6 signals through the Janus-activated kinases 2 (JAK2) and signal transducer and activator of transcription 3 (STAT3) pathway. The contribution of JAK2 signaling in inflammation-induced hyperalgesia has not been addressed previously. The role of this pathway was investigated using the JAK2 inhibitor, AG490, in a rat model of inflammatory pain. Unilateral hind paw inflammatory pain was induced in male Sprague-Dawley rats by intraplantar (i.pl.) injection of 3.5% lambda-carrageenan. Inflamed rats received an i.pl. injection of either 3.5% of dimethylsulfoxide or AG490 (1-10 mu g). The antinociceptive effects of AG490 were assessed by 2 pain behavioral assays 4 h later: The thermal and mechanical hyperalgesia tests. AG490 (1-10 mu g) significantly attenuated lambda-carrageenan-induced thermal hyperalgesia in a dosedependent manner. AG490 also reduced mechanical hyperalgesia. Co-administration of opioid receptor antagonist naloxone (10 mu g) and AG490 (10 mu g) did not reverse AG490-produced antinociceptive activity, suggesting that the mu-opioid receptor is not responsible for the anti-hyperalgesic effects of AG490. Therefore, we suggest that AG490 produces these effects by blocking JAK2 signaling. In conclusion, JAK2 inhibitors may represent a novel class of non-narcotic drugs to treat inflammatory pain.
C1 [Cheppudira, Bopaiah P.; Garza, Thomas H.; Petz, Lawrence N.; Clifford, John L.; Fowler, Marcie] US Army, Inst Surg Res, Battlefield Pain Management Res Task Area, Ft Sam Houston, TX 78234 USA.
RP Cheppudira, BP (reprint author), US Army, Inst Surg Res, Battlefield Pain Management Res Task Area, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA.
EM bopaiah.p.cheppudira.vol@mail.mil
NR 16
TC 3
Z9 3
U1 0
U2 1
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 2049-9434
EI 2049-9442
J9 BIOMED REP
JI Biomed. Rep.
PD SEP
PY 2015
VL 3
IS 5
BP 703
EP 706
DI 10.3892/br.2015.497
PG 4
WC Medicine, Research & Experimental
SC Research & Experimental Medicine
GA CT5GG
UT WOS:000362836300018
ER
PT J
AU Tsang, M
Fox-Lent, C
Wallace, S
Welp, T
Bates, M
Linkov, I
AF Tsang, Michael
Fox-Lent, Cate
Wallace, Sean
Welp, Tim
Bates, Matthew
Linkov, Igor
TI Life-cycle impacts of soybean and algae biodiesel: Case study of US
marine vessels
SO BIOFUELS BIOPRODUCTS & BIOREFINING-BIOFPR
LA English
DT Article
DE life-cycle assessment; biofuels; biodiesel; algae; soy; renewable energy
ID EMISSIONS
AB The push to find alternatives to fossil fuels has driven research and consumption of biofuels. Recent actions in the United States have placed an emphasis on the use of renewable fuels for improved sustainability of government operations. In 2013, the United States Army Corps of Engineers (USACE) measured atmospheric emissions from two navigation vessels consuming three different fuel types and found that biofuels have the potential to lower atmospheric emissions. These fuels have widely different production processes, however, and a full life-cycle assessment is necessary to provide a complete picture of these biofuels. The goal of this study was to identify whether transitioning navigation vessels to operate on biodiesel would have the potential to lower human health and environmental impacts. This study focuses on the complete life cycle of these fuels in USACE marine vessels by employing a well-to-wheels life-cycle assessment comparing the impacts of a 100% soy-based biodiesel and an algal-based biodiesel blend to a conventional diesel. Overall, soybean-based biodiesel had lower impacts compared to algal-based biodiesel. Impacts from conventional diesel were generally lower than algal-based biodiesel, but impacts between conventional diesel and soybean-based biodiesel were mixed. While greenhouse gas emissions during the use phase were reduced for the biofuels (after considering only the non-biogenic fraction of carbon emission), a complete look at the life-cycle resulted in cases where emissions could be greater than conventional diesel. Biodiesel impacts depended greatly on modeling assumptions made in the life-cycle system boundaries and inventory such as allocation method and assumptions about feedstock growth and harvesting. Published 2015. This article is a U.S. Government work and is in the public domain in the USA.
C1 [Tsang, Michael; Fox-Lent, Cate; Wallace, Sean; Welp, Tim; Bates, Matthew; Linkov, Igor] US Army Engineer Res & Dev Ctr, Concord, MA 01742 USA.
[Tsang, Michael] Univ Bordeaux, Bordeaux, France.
RP Linkov, I (reprint author), US Army Engineer Res & Dev Ctr, 696 Virginia Rd, Concord, MA 01742 USA.
EM igor.linkov@usace.army.mil
FU US Army Corps of Engineers' Dredging Operations and Environmental
Research program
FX The authors would like to acknowledge the funding provided by the US
Army Corps of Engineers' Dredging Operations and Environmental Research
program for the research described herein. This article has been
reviewed in accordance with the Agency's peer and administrative review
policies and approved for publication. Mention of trade names or
commercial products does not constitute an endorsement or recommendation
for use by the USACE. The research described in this paper does not
reflect official views of USACE which lends no official endorsement.
NR 35
TC 2
Z9 2
U1 7
U2 15
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1932-104X
EI 1932-1031
J9 BIOFUEL BIOPROD BIOR
JI Biofuels Bioprod. Biorefining
PD SEP-OCT
PY 2015
VL 9
IS 5
BP 567
EP 580
DI 10.1002/bbb.1569
PG 14
WC Biotechnology & Applied Microbiology; Energy & Fuels
SC Biotechnology & Applied Microbiology; Energy & Fuels
GA CT4AN
UT WOS:000362748200019
ER
PT J
AU Birt, AM
Champagne, VK
Sisson, RD
Apelian, D
AF Birt, A. M.
Champagne, V. K., Jr.
Sisson, R. D., Jr.
Apelian, D.
TI Microstructural analysis of Ti-6Al-4V powder for cold gas dynamic spray
applications
SO ADVANCED POWDER TECHNOLOGY
LA English
DT Article
DE Ti-6Al-4V; Microstructure; Powder; SEM; Nanohardness
ID ISOTHERMAL SPHERES; HEAT-TRANSFER; EVOLUTION
AB The importance of powder feedstock microstructure has been of relatively little interest in literature up until this point due to the melting or near melting processing conditions in most modern powder metallurgical techniques. The microstructure and resultant properties of consolidated materials in solid state processes, such as cold spray, are critically dependent on the feedstock powder. The focus of this paper is the characterization of plasma atomized Ti-6Al-4V powder using X-ray diffraction, scanning electron microscopy, and transmission electron microscopy. Results indicate that while most powders are martensitic due to high cooling rates, powders can also have an equiaxed cellular or featureless microstructure depending on particle size. (C) 2015 The Society of Powder Technology Japan. Published by Elsevier B.V. and The Society of Powder Technology Japan. All rights reserved.
C1 [Birt, A. M.; Sisson, R. D., Jr.; Apelian, D.] Worcester Polytech Inst, Worcester, MA 01609 USA.
[Champagne, V. K., Jr.] US Army Res Lab, Aberdeen Proving Ground, MD USA.
RP Birt, AM (reprint author), 100 Inst Rd,Washburn Shops Off 315, Worcester, MA 01609 USA.
EM birt.aaron@gmail.com
FU U.S. Army Research Laboratory [W911NF-10-2-0098]
FX Special thanks to U.S. Army Research Laboratory Contract
#:W911NF-10-2-0098 for sponsoring and directing this research, as well
as taking the time to consult and prepare samples.
NR 35
TC 1
Z9 1
U1 3
U2 7
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0921-8831
EI 1568-5527
J9 ADV POWDER TECHNOL
JI Adv. Powder Technol.
PD SEP
PY 2015
VL 26
IS 5
BP 1335
EP 1347
DI 10.1016/j.apt.2015.07.008
PG 13
WC Engineering, Chemical
SC Engineering
GA CS2RR
UT WOS:000361919300011
ER
PT J
AU Richmond, AK
Malcomb, D
Ringler, K
AF Richmond, Amy Krakowka
Malcomb, Dylan
Ringler, Kristine
TI Household vulnerability mapping in Africa's Rift Valley
SO APPLIED GEOGRAPHY
LA English
DT Article
DE Vulnerability; Geospatial modeling; East Africa; Field work
ID SUB-SAHARAN AFRICA; CLIMATE-CHANGE; CONSERVATION; AGRICULTURE;
ADAPTATION; INSECURITY; RESILIENCE; UGANDA; LAND
AB This study develops an interdisciplinary framework to investigate the relationship between environmental processes and human wellbeing that can be adapted to any geographic location. Based on the use and availability of open-source data, the methodology advanced in this research has the capacity to examine household-level drivers of vulnerability that are rarely accounted for in regional and global indices. A household level vulnerability analysis is conducted for four countries Malawi, Uganda, Rwanda, and Ethiopia. This research seeks to develop a vulnerability model that can be both applied to vulnerable countries in the East African Rift and offer insight into internal dynamic processes and drivers of vulnerability. The enhanced methodology presented in this paper can assist stakeholders and policy-makers in determining what drives vulnerability at a household level, where vulnerable populations are, and suggest what type of aid to target specific locations to be of greatest benefit. Published by Elsevier Ltd.
C1 [Richmond, Amy Krakowka; Malcomb, Dylan; Ringler, Kristine] US Mil Acad, Dept Geog & Environm Engn, West Point, NY USA.
RP Richmond, AK (reprint author), 745 Brewerton Ave, West Point, NY 10996 USA.
EM amy.krakowka@usma.edu
FU DoD Minerva
FX We would like to acknowledge our colleagues and students that assisted
in conducting field work and interviews: Dr. Christopher Oxendine,
Elizabeth Weaver, Maria Fabi, Kelly Redmond, Ian Myers, Saverio Macrina,
Jake Link, Tyler Tingstrom, Kyle Okular, and Ethan Kindly. In addition
we would like to thank Professor Ranga Myneni and Taejin Park at Boston
University for their invaluable help providing and processing the NDVI
data. We would also like to thank DoD Minerva for funding this research.
NR 74
TC 2
Z9 2
U1 1
U2 11
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0143-6228
EI 1873-7730
J9 APPL GEOGR
JI Appl. Geogr.
PD SEP
PY 2015
VL 63
BP 380
EP 395
DI 10.1016/j.apgeog.2015.07.013
PG 16
WC Geography
SC Geography
GA CS4PZ
UT WOS:000362059700036
ER
PT J
AU Burmeister, DM
Ponticorvo, A
Yang, B
Becerra, SC
Choi, B
Durkin, AJ
Christy, RJ
AF Burmeister, David M.
Ponticorvo, Adrien
Yang, Bruce
Becerra, Sandra C.
Choi, Bernard
Durkin, Anthony J.
Christy, Robert J.
TI Utility of spatial frequency domain imaging (SFDI) and laser speckle
imaging (LSI) to non-invasively diagnose burn depth in a porcine model
SO BURNS
LA English
DT Article
DE Burn diagnosis; Non-invasive imaging; Swine
ID QUANTITATIVE ASSESSMENT; DOPPLER; INJURY; PROGRESSION; EXCISION;
NECROSIS; STASIS; WOUNDS; SWINE; ZONE
AB Surgical intervention of second degree burns is often delayed because of the difficulty in visual diagnosis, which increases the risk of scarring and infection. Non-invasive metrics have shown promise in accurately assessing burn depth. Here, we examine the use of spatial frequency domain imaging (SFDI) and laser speckle imaging (LSI) for predicting burn depth. Contact burn wounds of increasing severity were created on the dorsum of a Yorkshire pig, and wounds were imaged with SFDI/LSI starting immediately after-burn and then daily for the next 4 days. In addition, on each day the burn wounds were biopsied for histological analysis of burn depth, defined by collagen coagulation, apoptosis, and adnexal/vascular necrosis. Histological results show that collagen coagulation progressed from day 0 to day 1, and then stabilized. Results of burn wound imaging using non-invasive techniques were able to produce metrics that correlate to different predictors of burn depth. Collagen coagulation and apoptosis correlated with SFDI scattering coefficient parameter (mu'(s)) and adnexal/vascular necrosis on the day of burn correlated with blood flow determined by LSI. Therefore, incorporation of SFDI scattering coefficient and blood flow determined by LSI may provide an algorithm for accurate assessment of the severity of burn wounds in real time. Published by Elsevier Ltd and ISBI
C1 [Burmeister, David M.; Becerra, Sandra C.; Christy, Robert J.] US Army Inst Surg Res, JBSA, Ft Sam Houston, TX 78234 USA.
[Ponticorvo, Adrien; Yang, Bruce; Choi, Bernard] Univ Calif Irvine, Beckman Laser Inst & Med Clin, Irvine, CA 92617 USA.
[Choi, Bernard; Durkin, Anthony J.] Univ Calif Irvine, Dept Biomed Engn, Nat Sci 2 3120, Irvine, CA 92697 USA.
RP Christy, RJ (reprint author), US Army Inst Surg Res, Extrem Trauma & Regenerat Med, JBSA, 3698 Chambers Pass,BHT1 Bldg 3611, Ft Sam Houston, TX 78234 USA.
EM Robert.j.christy12.civ@mail.mil
FU Medical Research and Materiel Command (MRMC); National Institutes of
Health/NIBIB [P41EB015890]; Military Medical Photonics Program
[FA9550-10-1-0538]; Arnold and Mabel Beckman Foundation
FX The authors would like to thank the USAISR Veterinary Staff for their
technical assistance with surgeries. Medical Research and Materiel
Command (MRMC) provided funding for this project. Additional support is
provided by the National Institutes of Health/NIBIB funded LAMMP
(P41EB015890), the Military Medical Photonics Program
(FA9550-10-1-0538), and the Arnold and Mabel Beckman Foundation.
NR 50
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Z9 9
U1 4
U2 15
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0305-4179
EI 1879-1409
J9 BURNS
JI Burns
PD SEP
PY 2015
VL 41
IS 6
BP 1242
EP 1252
DI 10.1016/j.burns.2015.03.001
PG 11
WC Critical Care Medicine; Dermatology; Surgery
SC General & Internal Medicine; Dermatology; Surgery
GA CS2SB
UT WOS:000361920800016
PM 26138371
ER
PT J
AU Richard, M
Morse, B
Daly, SF
AF Richard, Martin
Morse, Brian
Daly, Steven F.
TI Modeling frazil ice growth in the St. Lawrence River
SO CANADIAN JOURNAL OF CIVIL ENGINEERING
LA English
DT Article
DE frazil ice; St. Lawrence River; heat budget; ice crystal growth;
acoustic measurements
ID SEA-ICE; HEAT-BUDGET; BOWEN-RATIO
AB The paper presents a complete energy balance model of suspended frazil ice formation in the tidal water column of the St. Lawrence River. The model estimates of suspended frazil ice concentration are compared to in situ observations of an analogue of suspended frazil ice crystals, with good results. A time series of observed acoustic backscattering from suspended frazil serves as the analogue of the suspended frazil concentration. The model of frazil ice growth is used to estimate the rate of increase in mass of the suspended frazil ice by balancing the net rate of energy exchange with the atmosphere with the observed changes in water temperature and in anchor ice thickness. The positive results are achieved despite a number of difficulties with analysis. These difficulties include the bias resulting from the inability of the sonar to detect across the complete size range of suspended ice, the unknown impacts of advection, the unknown impact of anchor ice build-up on temperature and sonar readings, and the lack of knowledge regarding the accuracy of sonar estimation of anchor ice thickness. These results highlight the promise of models, suitably applied, and sonar to quantitatively estimate suspended frazil ice concentration.
C1 [Richard, Martin] C CORE, Ice Engn, St John, NF A1B 3X5, Canada.
[Morse, Brian] Univ Laval, Dept Civil Engn, Quebec City, PQ G1K 7P4, Canada.
[Daly, Steven F.] US Army ERDC, CRREL, Hanover, NH 03779 USA.
RP Richard, M (reprint author), C CORE, Ice Engn, St John, NF A1B 3X5, Canada.
EM martin.richard@c-core.ca
FU NSERC
FX The authors thank the City of Quebec; Dr. Edward Stander from the State
University of New York, Cobleskill; colleagues at Laval University
(Donon Bisanswa, Annie-Claude Parent, Dany Crepault, and Dr. Rock
Santerre); and Dr. Edgar L. Andreas for making freely available Fortran
code for computing turbulent fluxes. The instrumentation work was
partially supported by a NSERC discovery grant.
NR 41
TC 0
Z9 0
U1 2
U2 2
PU CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 0315-1468
EI 1208-6029
J9 CAN J CIVIL ENG
JI Can. J. Civ. Eng.
PD SEP
PY 2015
VL 42
IS 9
SI SI
BP 592
EP 608
DI 10.1139/cjce-2014-0082
PG 17
WC Engineering, Civil
SC Engineering
GA CS3MC
UT WOS:000361977500003
ER
PT J
AU Johnson, DF
Mattson, WD
AF Johnson, Donald F.
Mattson, William D.
TI Theoretical investigations of surface reconstruction on C nanodiamonds
and cubic-BN nanoparticles
SO DIAMOND AND RELATED MATERIALS
LA English
DT Article
DE Detonation nanodiamond; Boron nitride nanoparticles; Surface morphology;
Density functional theory
ID AB-INITIO CALCULATION; BORON-NITRIDE; ELECTRONIC-PROPERTIES; ICOSAHEDRAL
DIAMONDOIDS; ZINCBLENDE BN; CARBON ONIONS; PRESSURE; PSEUDOPOTENTIALS;
FULLERANES; STABILITY
AB Using first-principles DFT calculations, we have investigated morphology effects on the properties due to surface reconstruction of C nanodiamond and cubic-BN nanoparticles. Geometry optimization of simple sphere-like nanoparticles leads to spontaneous formation of nanocages on the particle surfaces. Differences are seen at B and N 3-fold surface sites, which are flat and pyramidal, respectively. Thermal annealing using quantum molecular dynamics simulations shows nanocage formation in both materials, primarily on (111) surfaces. (C) 2015 Elsevier B.V. All rights reserved.
C1 [Johnson, Donald F.; Mattson, William D.] Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA.
RP Johnson, DF (reprint author), Army Res Lab, Weap & Mat Res Directorate, RDRL WML B Bldg 4600, Aberdeen Proving Ground, MD 21005 USA.
EM donald.f.johnson129.ctr@mail.mil; william.d.mattson6.civ@mail.mil
FU Army Research Laboratory
FX Research was sponsored by the Army Research Laboratory and was
accomplished under Cooperative Agreement Number W911NF-12-2-0019.
Computer time was provided via the HPCMP project: Chemistry and Physics
of Energetic Materials. Calculations were performed at the DoD
Supercomputing Resource Center located at the Information Technology
Laboratory, Vicksburg, MS.
NR 42
TC 0
Z9 0
U1 9
U2 25
PU ELSEVIER SCIENCE SA
PI LAUSANNE
PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND
SN 0925-9635
EI 1879-0062
J9 DIAM RELAT MATER
JI Diam. Relat. Mat.
PD SEP
PY 2015
VL 58
BP 155
EP 160
DI 10.1016/j.diamond.2015.07.001
PG 6
WC Materials Science, Multidisciplinary
SC Materials Science
GA CS5SA
UT WOS:000362137100023
ER
PT J
AU Sloan, SD
Peterie, SL
Miller, RD
Ivanov, J
Schwenk, JT
McKenna, JR
AF Sloan, Steven D.
Peterie, Shelby L.
Miller, Richard D.
Ivanov, Julian
Schwenk, J. Tyler
McKenna, Jason R.
TI Detecting clandestine tunnels using near-surface seismic techniques
SO GEOPHYSICS
LA English
DT Article
ID WAVES
AB Geophysical detection of clandestine tunnels is a complex problem that has met with limited success. Multiple methods have been applied, spanning several decades, but a reliable solution has yet to be found. We evaluated shallow seismic data collected at a tunnel test site representative of geologic settings found along the southwestern U.S. border. Our results demonstrated the capability of using P-wave diffraction and surface-wave backscatter techniques to detect a purpose-built subterranean tunnel. Near-surface seismic data were also collected at multiple sites in Afghanistan to detect and locate subsurface anomalies, including data collected over the escape tunnel discovered in 2011 at the Sarposa Prison in Kandahar, Afghanistan, which allowed more than 480 prisoners to escape, and data from another shallow tunnel recently discovered at an undisclosed location. The final example from Afghanistan was the first time surface-based geophysical methods have detected a tunnel whose presence and location was not previously known. Seismic results directly led to the discovery of the tunnel. Interpreted tunnel locations for all examples were within less than 2 m of the actual location. Seismic surface-wave backscatter and body-wave diffraction methods showed promise for efficient data acquisition and processing for locating purposefully hidden tunnels within unconsolidated sediments.
C1 [Sloan, Steven D.; Schwenk, J. Tyler] XRI Geophys LLC, Vicksburg, MS 39180 USA.
[Peterie, Shelby L.; Miller, Richard D.; Ivanov, Julian] Kansas Geol Survey, Lawrence, KS 66044 USA.
[McKenna, Jason R.] United States Army Engn Res & Dev Ctr, Vicksburg, MS USA.
RP Sloan, SD (reprint author), XRI Geophys LLC, Vicksburg, MS 39180 USA.
EM steve.sloan@xrigeo.com; speterie@kgs.ku.edu; rmiller@kgs.ku.edu;
jivanov@kgs.ku.edu; tyler.schwenk@xrigeo.com; jason.mckenna@4qtrs.net
OI Ivanov, Julian/0000-0002-7099-8051
NR 22
TC 3
Z9 3
U1 1
U2 1
PU SOC EXPLORATION GEOPHYSICISTS
PI TULSA
PA 8801 S YALE ST, TULSA, OK 74137 USA
SN 0016-8033
EI 1942-2156
J9 GEOPHYSICS
JI Geophysics
PD SEP-OCT
PY 2015
VL 80
IS 5
BP EN127
EP EN135
DI 10.1190/GEO2014-0529.1
PG 9
WC Geochemistry & Geophysics
SC Geochemistry & Geophysics
GA CR9HP
UT WOS:000361665500008
ER
PT J
AU Rose, R
Klemcke, HG
AF Rose, Rajiv
Klemcke, Harold G.
TI Relationship between Plasma Albumin Concentration and Plasma Volume in 5
Inbred Rat Strains
SO JOURNAL OF THE AMERICAN ASSOCIATION FOR LABORATORY ANIMAL SCIENCE
LA English
DT Article
ID BOUND EVANS BLUE; HEMORRHAGIC-SHOCK; SERUM-ALBUMIN; BLOOD-VOLUME;
ENDOTHELIAL PERMEABILITY; INTENSIVE-CARE; SURVIVAL-TIME; HEART-FAILURE;
TRANSPORT; RESUSCITATION
AB Using the Evans Blue procedure, we previously found strain-related differences in plasma volumes in 5 inbred rat strains. Because albumin binds strongly with Evans blue, this protein is important in the Evans blue method of plasma volume determination. Therefore, we speculated that interstrain differences in plasma albumin concentration (PAC) could distort calculated plasma volumes. To address this concern, we used ELISA techniques to measure PAC in these inbred rat strains. In study A, the blood volume was measured by using Evans blue dye, and albumin was measured at the start of hemorrhage. In study B, blood volume was not measured, and albumin was measured twice, near the start and end of hemorrhage (approximately 14 min apart). Neither study revealed any interstrain differences in PAC, which decreased after hemorrhage in all 5 strains. No correlation was found between PAC and plasma volume, survival time, blood lactate, or blood base excess. Percentage changes in PAC during hemorrhage were greater in salt-sensitive compared with Lewis rats. Moreover, these percentage changes were associated with survival time in Fawn hooded hypertensive rats. Our data show that the plasma volumes we measured previously were not misrepresented due to variations in PAC.
C1 [Rose, Rajiv; Klemcke, Harold G.] JBSA Ft Sam Houston, US Army Inst Surg Res, Houston, TX 78234 USA.
RP Klemcke, HG (reprint author), JBSA Ft Sam Houston, US Army Inst Surg Res, Houston, TX 78234 USA.
EM harold.g.klemcke.ctr@mail.mil
FU US Army Medical Research and Materiel Command
FX We thank Mariam Calderon and Dr Thomas Oh (US Army Institute of Surgical
Research) for their assistance with rat experiments and LTC Kenneth
Jacobsen (Attending Veterinarian) for information concerning rat housing
and pathogen status of our inbred rat strains. We also thank Dr Bijan
Kheirabadi for his critical comments on the paper. The opinions or
assertions contained herein are the private views of the authors and are
not to be construed as official or as reflecting the views of the
Department of the Army or the Department of Defense. This research was
conducted on funds from the US Army Medical Research and Materiel
Command.
NR 41
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC LABORATORY ANIMAL SCIENCE
PI MEMPHIS
PA 9190 CRESTWYN HILLS DR, MEMPHIS, TN 38125 USA
SN 1559-6109
J9 J AM ASSOC LAB ANIM
JI J. Amer. Assoc. Lab. Anim. Sci.
PD SEP
PY 2015
VL 54
IS 5
BP 459
EP 464
PG 6
WC Veterinary Sciences; Zoology
SC Veterinary Sciences; Zoology
GA CS4OS
UT WOS:000362056000001
PM 26424242
ER
PT J
AU Wetzel, ED
Balu, R
Beaudet, TD
AF Wetzel, Eric D.
Balu, Radhakrishnan
Beaudet, Todd D.
TI A theoretical consideration of the ballistic response of continuous
graphene membranes
SO JOURNAL OF THE MECHANICS AND PHYSICS OF SOLIDS
LA English
DT Article
DE Graphene; Ballistics; Armor; Impact; Textiles
ID SPACE GAUSSIAN PSEUDOPOTENTIALS; MECHANICAL-PROPERTIES; INTRINSIC
STRENGTH; GRAIN-BOUNDARIES; DENSITY; BEHAVIOR; FIBER; PENETRATION;
PERFORMANCE; IMPACT
AB The remarkable properties of graphene, including unusually high mechanical strength and stiffness, have been well-documented. In this paper, we combine an analytical solution for ballistic impact into a thin isotropic membrane, with ab initio density functional theory calculations for graphene under uniaxial tension, to predict the penetration resistance of multi-layer graphene membranes. The calculations show that continuous graphene membranes could enable ballistic barriers of extraordinary performance, enabling resistance to penetration at masses up to 100 x lighter than existing state-of-the-art barrier materials. The very high elastic wave speed and strain energy to failure are the major drivers of this increase in performance. However, the in-plane mechanical isotropy of graphene, as compared to conventional orthotropic woven textiles, also contributes significantly to the efficiency of graphene as a barrier material. This result suggests that, for barrier applications, isotropic membranes composed of covalently bonded two-dimensional molecular networks could provide distinct advantages over fiber-based textiles derived from linear polymers. Published by Elsevier Ltd.
C1 [Wetzel, Eric D.] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA.
US Army Res Lab, Computat & Informat Sci Directorate, Aberdeen Proving Ground, MD 21005 USA.
RP Wetzel, ED (reprint author), US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA.
EM eric.d.wetzel2.civ@mail.mil
FU U.S. Department of Energy; ARL; ARL DoD Supercomputing Resource Center
(DSRC) modernization program
FX This research was supported in part by an appointment to the
Postgraduate Research Participation Program at the U.S. Army Research
Laboratory (ARL) administered by the Oak Ridge Institute for Science and
Education through an interagency agreement between the U.S. Department
of Energy and ARL. This work was made possible by an internal grant from
the ARL DoD Supercomputing Resource Center (DSRC) modernization program.
NR 46
TC 4
Z9 4
U1 6
U2 38
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-5096
EI 1873-4782
J9 J MECH PHYS SOLIDS
JI J. Mech. Phys. Solids
PD SEP
PY 2015
VL 82
BP 23
EP 31
DI 10.1016/j.jmps.2015.05.008
PG 9
WC Materials Science, Multidisciplinary; Mechanics; Physics, Condensed
Matter
SC Materials Science; Mechanics; Physics
GA CS2SN
UT WOS:000361922100002
ER
PT J
AU Fan, YF
Dong, JB
Lou, JL
Wen, WH
Conrad, F
Geren, IN
Garcia-Rodriguez, C
Smith, TJ
Smith, LA
Ho, MF
Pires-Alves, M
Wilson, BA
Marks, JD
AF Fan, Yongfeng
Dong, Jianbo
Lou, Jianlong
Wen, Weihua
Conrad, Fraser
Geren, Isin N.
Garcia-Rodriguez, Consuelo
Smith, Theresa J.
Smith, Leonard A.
Ho, Mengfei
Pires-Alves, Melissa
Wilson, Brenda A.
Marks, James D.
TI Monoclonal Antibodies that Inhibit the Proteolytic Activity of Botulinum
Neurotoxin Serotype/B
SO TOXINS
LA English
DT Article
DE botulinum antitoxin; inhibitory antibodies; Botulinum neurotoxin
serotype B; alpha-exosite
ID MOTOR-NERVE TERMINALS; DOMAIN-BASED ASSAYS; TOXIN TYPE-A; MOLECULAR
EVOLUTION; TARGETED DELIVERY; AFFINITY; PROTEIN; CLEAVAGE; BINDING;
CHAIN
AB Existing antibodies (Abs) used to treat botulism cannot enter the cytosol of neurons and bind to botulinum neurotoxin (BoNT) at its site of action, and thus cannot reverse paralysis. However, Abs targeting the proteolytic domain of the toxin could inhibit the proteolytic activity of the toxin intracellularly and potentially reverse intoxication, if they could be delivered intracellularly. As such, antibodies that neutralize toxin activity could serve as potent inhibitory cargos for therapeutic antitoxins against botulism. BoNT serotype B (BoNT/B) contains a zinc endopeptidase light chain (LC) domain that cleaves synaoptobrevin-2, a SNARE protein responsible for vesicle fusion and acetylcholine vesicle release. To generate monoclonal Abs (mAbs) that could reverse paralysis, we targeted the protease domain for Ab generation. Single-chain variable fragment (scFv) libraries from immunized mice or humans were displayed on yeast, and 19 unique BoNT/B LC-specific mAbs isolated by fluorescence-activated cell sorting (FACS). The equilibrium dissociation constants (K-D) of these mAbs for BoNT/B LC ranged from 0.24 nM to 14.3 nM (mean K-D 3.27 nM). Eleven mAbs inhibited BoNT/B LC proteolytic activity. The fine epitopes of selected mAbs were identified by alanine-scanning mutagenesis, revealing that inhibitory mAbs bound near the active site, substrate-binding site or the extended substrate-binding site. The results provide mAbs that could prove useful for intracellular reversal of paralysis and identify epitopes that could be targeted by small molecules inhibitors.
C1 [Fan, Yongfeng; Dong, Jianbo; Lou, Jianlong; Wen, Weihua; Conrad, Fraser; Geren, Isin N.; Garcia-Rodriguez, Consuelo; Marks, James D.] Univ Calif San Francisco, San Francisco Gen Hosp, Dept Anesthesia & Perioperat Care, San Francisco, CA 94110 USA.
[Smith, Theresa J.] US Army, Med Inst Infect Dis, Mol & Translat Sci Div, Ft Detrick, MD 21702 USA.
[Smith, Leonard A.] US Army, Med Res Inst Infect Dis, Med Countermeasures Technol, Ft Detrick, MD 21702 USA.
[Ho, Mengfei; Pires-Alves, Melissa; Wilson, Brenda A.] Univ Illinois, Dept Microbiol, Urbana, IL 61801 USA.
RP Marks, JD (reprint author), Univ Calif San Francisco, San Francisco Gen Hosp, Dept Anesthesia & Perioperat Care, Room 3C-38,1001 Potrero Ave, San Francisco, CA 94110 USA.
EM frank.fan@ucsf.edu; jianbo.dong@ucsf.edu; jianlong.lou@ucsf.edu;
wei.wen@ucsf.edu; Conrad.fraser@ucsf.edu; isin.geren@medeniyet.edu.tr;
MariaConsuelo.Garcia@ucsf.edu; theresa.j.smith.civ@mail.mil;
Leonard.A.Smith1.civ@mail.mil; mho1@illinois.edu; melalves@illinois.edu;
bawilson@life.illinois.edu; jim.marks@ucsf.edu
FU National Institute of Health (NIH)/National Institute of Allergy and
Infectious Diseases (NIAID) [U01 AI056493]; DTRA [HDTRA1-07-C-0030];
NIH/NIAID [R21/R33 AI101504, U01 AI075502, U54 AI0571530]
FX This work was funded in part by the National Institute of Health
(NIH)/National Institute of Allergy and Infectious Diseases (NIAID)
under Cooperative Agreement U01 AI056493 (to JDM), DTRA contract
HDTRA1-07-C-0030 (to JDM), NIH/NIAID R21/R33 AI101504 (to BAW),
NIH/NIAID U01 AI075502 (to BAW), and NIH/NIAID subcontract under U54
AI0571530 (to BAW). Opinions, interpretations, conclusions, and
recommendations are those of the authors and not necessarily endorsed by
the U.S. Army, NIAID, or the NIH.
NR 41
TC 1
Z9 1
U1 3
U2 3
PU MDPI AG
PI BASEL
PA POSTFACH, CH-4005 BASEL, SWITZERLAND
SN 2072-6651
J9 TOXINS
JI Toxins
PD SEP
PY 2015
VL 7
IS 9
BP 3405
EP 3423
DI 10.3390/toxins7093405
PG 19
WC Toxicology
SC Toxicology
GA CS0OU
UT WOS:000361762200003
PM 26343720
ER
PT J
AU Halford, ZA
Yu, PYC
Likeman, RK
Hawley-Molloy, JS
Thomas, C
Bingham, JP
AF Halford, Zan A.
Yu, Peter Y. C.
Likeman, Robert K.
Hawley-Molloy, Joshua S.
Thomas, Craig
Bingham, Jon-Paul
TI Cone shell envenomation: epidemiology, pharmacology and medical care
SO DIVING AND HYPERBARIC MEDICINE
LA English
DT Review
DE First aid; envenomation; toxins; pharmacology - marine; deaths;
symptoms; treatment; review article
ID MARINE SNAIL CONUS; NICOTINIC ACETYLCHOLINE-RECEPTOR; GEOGRAPHUS VENOM;
MILKED VENOM; NMR-SPECTROSCOPY; PEPTIDE; DIVERSITY; PREY; PURIFICATION;
CALIFORNICUS
AB The marine environment presents much danger, specifically in regards to the numerous venomous inhabitants within tropical and subtropical waters. The toxins from one such group of venomous marine snails, commonly referred to as 'cone snails', have been well documented in causing human fatalities. Yet information regarding medical treatment for cone snail envenomation is limited and poorly accessible. To correct this, medical and scientific expertise and literary review on Conus provide a basic and comprehensive directive focused on the medical treatment and post-mortem investigative analysis of cone snail envenomation. We emphasize what we expect to be the most lethal feeding group of Conus and provide a brief background to the epidemiology of their stings. We describe the venom apparatus of Conus and its utility of rapid venom delivery. We have compiled the documented incidences of Conus envenomation to offer thorough reference of known signs and symptoms - this too drawing on personal experiences in the field. We have also made available a brief background to the biochemistry and pharmacology of Conus venoms to highlight their complex nature.
C1 [Halford, Zan A.; Yu, Peter Y. C.; Bingham, Jon-Paul] Univ Hawaii, Dept Mol Biosci & Bioengn, Honolulu, HI 96822 USA.
[Likeman, Robert K.] Directorate Army Hlth, Dept Def, Canberra, ACT, Australia.
[Hawley-Molloy, Joshua S.] Tripler Army Med Ctr, Dept Med, Honolulu, HI 96859 USA.
[Thomas, Craig] Hawaii Emergency Phys Associated, Kailua, HI USA.
[Likeman, Robert K.] Army Hlth, Dept Def, Canberra, ACT, Australia.
RP Bingham, JP (reprint author), Univ Hawaii, Coll Trop Agr & Human Resources, Dept Mol Biosci & Bioengn, Honolulu, HI 96822 USA.
EM jbingham@hawaii.edu
FU USDA TSTAR [2009-34135-20067]; HATCH [HAW00595-R]
FX We wish to acknowledge the continued financial support from the USDA
TSTAR (#2009-34135-20067; J-P.B.) and HATCH (HAW00595-R; J-P.B.) that
have helped expand our horizons in peptide toxins from cone snails.
NR 59
TC 3
Z9 3
U1 2
U2 9
PU SOUTH PACIFIC UNDERWATER MED SOC
PI MELBOURNE
PA C/O AUSTRALIAN & NEW ZEALAND COLL ANAESTHETISTS, 630 ST KILDA RD,
MELBOURNE, VIC 3004, AUSTRALIA
SN 1833-3516
J9 DIVING HYPERB MED
JI Diving Hyperb. Med.
PD SEP
PY 2015
VL 45
IS 3
BP 200
EP 207
PG 8
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA CR9RL
UT WOS:000361694200009
PM 26415072
ER
PT J
AU Torrealday, S
Pal, L
AF Torrealday, Saioa
Pal, Lubna
TI Premature Menopause
SO ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA
LA English
DT Article
DE Premature menopause; Primary ovarian insufficiency; Premature ovarian
failure; Hypergonadotropic hypogonadism; Surgical menopause
ID PRIMARY OVARIAN INSUFFICIENCY; AUTOIMMUNE OOPHORITIS; POSITION
STATEMENT; FAILURE; WOMEN; RESERVE; DEHYDROEPIANDROSTERONE;
TESTOSTERONE; DYSFUNCTION; MECHANISMS
AB A heterogeneous disorder, premature menopause is not an uncommon entity, affecting approximately 1% of women younger than 40 years. Multisystem implications are recognized as sequelae to the premature deprivation of ovarian steroids, posing unique health-related challenges in this population. An integrated management approach that addresses both the physical and psychological health concerns and the overall well-being of this relatively chronologically young population is paramount.
C1 [Torrealday, Saioa] Womack Army Med Ctr, Dept Obstet & Gynecol, Reprod Endocrinol & Infertil, Ft Bragg, NC 28311 USA.
[Pal, Lubna] Yale Univ, Sch Med, Dept Obstet Gynecol & Reprod Sci, Div Reprod Endocrinol & Infertil, New Haven, CT 06510 USA.
RP Pal, L (reprint author), Yale Univ, Sch Med, Dept Obstet Gynecol & Reprod Sci, Div Reprod Endocrinol & Infertil, 333 Cedar St, New Haven, CT 06510 USA.
EM lubna.pal@yale.edu
NR 56
TC 4
Z9 4
U1 2
U2 5
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0889-8529
EI 1558-4410
J9 ENDOCRIN METAB CLIN
JI Endocrinol. Metabol. Clin. North Amer.
PD SEP
PY 2015
VL 44
IS 3
BP 543
EP +
DI 10.1016/j.ecl.2015.05.004
PG 16
WC Endocrinology & Metabolism
SC Endocrinology & Metabolism
GA CS0UF
UT WOS:000361777000008
PM 26316242
ER
PT J
AU Turell, MJ
Britch, SC
Aldridge, RL
Xue, RD
Smith, ML
Cohnstaedt, LW
Linthicum, KJ
AF Turell, Michael J.
Britch, Seth C.
Aldridge, Robert L.
Xue, Rui-De
Smith, Mike L.
Cohnstaedt, Lee W.
Linthicum, Kenneth J.
TI Potential for Psorophora columbiae and Psorophora ciliata Mosquitoes
(Diptera: Culicidae) to Transmit Rift Valley Fever Virus
SO JOURNAL OF MEDICAL ENTOMOLOGY
LA English
DT Article
DE competence; vector; transmission; North America
ID NORTH-AMERICAN MOSQUITOS; SAUDI-ARABIA; CULEX-PIPIENS; VECTOR
COMPETENCE; UNITED-STATES; WEST-AFRICA; EPIDEMIC; DISSEMINATION;
OUTBREAK; EGYPT
AB Rift Valley fever virus (RVFV) continues to pose a threat to much of the world. Unlike many arboviruses, numerous mosquito species have been associated with RVFV in nature, and many species have been demonstrated as competent vectors in the laboratory. In this study, we evaluated two field-collected Psorophora species, Psorophora columbiae (Dyar and Knab) and Psorophora ciliata (F.) for their potential to transmit RVFV in North America. Both species were susceptible to infection after feeding on a hamster with a viremia of 10(7) plaque-forming units/ml, with infection rates of 65 and 83% for Ps. columbiae and Ps. ciliata, respectively (with nearly all specimens becoming infected when feeding on a hamster with a higher viremia). However, both species had a significant salivary gland barrier, as only 2/35 Ps. columbiae and 0/3 Ps. ciliata with a disseminated infection transmitted virus by bite. Despite the presence of the salivary gland barrier, due to the very high population that can occur and its propensity to feed on large mammals, Ps. columbiae might play a role in amplifying RVFV should that virus be introduced into an area where this species is common.
C1 [Turell, Michael J.] US Army Med Res Inst Infect Dis, Div Virol, Dept Vector Assessment, Ft Detrick, MD 21702 USA.
[Britch, Seth C.; Aldridge, Robert L.; Linthicum, Kenneth J.] USDA ARS, Ctr Med Agr & Vet Entomol, Gainesville, FL 32608 USA.
[Xue, Rui-De; Smith, Mike L.] Anastasia Mosquito Control Dist St Johns Cty, St Augustine, FL 32080 USA.
[Cohnstaedt, Lee W.] USDA ARS, Arthropod Borne Anim Dis Res Unit, Ctr Grain & Anim Hlth Res, Manhattan, KS 66502 USA.
RP Turell, MJ (reprint author), US Army Med Res Inst Infect Dis, Div Virol, Dept Vector Assessment, Ft Detrick, MD 21702 USA.
EM michael.j.turell.civ@mail.mil
FU U.S. Department of Homeland Security Science and Technology Directorate
[HSHQDC-11-X-00326]
FX We thank Jeremy Wittie, Gregory White, Melissa Snelling, and Arturo
Gutierrez (Coachella Valley Mosquito and Vector Control District, Indio,
CA) for providing the Psorophora specimens from California. Their expert
support of mosquito collections and their handling and shipping of live
specimens from field sites in the Coachella Valley, CA, were critical to
this study. We thank S. Padilla, S. Pisarcik, and J. Hinson (USAMRIID)
for processing and testing mosquito specimens; and J. Williams
(USAMRIID) for caring for the hamsters. This work was supported by a
grant HSHQDC-11-X-00326 from the U.S. Department of Homeland Security
Science and Technology Directorate.
NR 45
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Z9 3
U1 0
U2 6
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0022-2585
EI 1938-2928
J9 J MED ENTOMOL
JI J. Med. Entomol.
PD SEP
PY 2015
VL 52
IS 5
BP 1111
EP 1116
DI 10.1093/jme/tjv093
PG 6
WC Entomology; Veterinary Sciences
SC Entomology; Veterinary Sciences
GA CS0PS
UT WOS:000361764900045
PM 26336233
ER
PT J
AU Mehta, AJ
Letter, JV
AF Mehta, Ashish J.
Letter, Joseph V., Jr.
TI Cohesive/cohesionless sediment transition diameter from settling
velocity data
SO OCEAN DYNAMICS
LA English
DT Article
DE Electrochemical attraction; Flocculation factor; Flocculation kinetics;
Physicochemical properties; Settling velocity distribution
ID EROSION
AB Mathematical models designed to simulate the movement of cohesive and cohesionless particles require as input the diameter d (T) specifying the transition between these two transport modes. As an effort to identify this diameter, Migniot (La Houille Blanche, 7, 591-620, 1968) measured in a water-filled column the settling velocities of flocs and respective deflocculated particles of mainly mineral cohesive sediments. The data were plotted as the ratio of the floc settling velocity to the particle velocity, called the flocculation factor F (f) , against particle diameter d (s) . The trend line was found to approximately follow an empirical power-law such that F (f) increased rapidly as d (s) decreased below d (T) estimated to be about 30 mu m at F (f) = 1. Assuming fractal self-similarity among falling flocs, the power-law exponent of 5/3 is shown to correspond to a fractal dimension of 2.65 implying that the flocs were densely packed. The diameter d (T) depends on the electrochemical properties of the suspended particles as well as the kinetics of floc growth and breakup, hence to an extent on the method of determination of d (T) . Its value deduced more directly from measurement of the critical shear stress for erosion of flocs at the surface of cohesive sediment beds has been reported to be about 10 mu m, which is lower than 30 mu m. Among other reasons, it is likely that the difference is rooted in the limited experimental information available as well as difficulty in characterizing the effect of highly graded distributions of the particle settling velocity.
C1 [Mehta, Ashish J.] Nutech Consultants Inc, Gainesville, FL 32606 USA.
[Letter, Joseph V., Jr.] US Army, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA.
RP Mehta, AJ (reprint author), Nutech Consultants Inc, Gainesville, FL 32606 USA.
EM mehtanutechinc@gmail.com
NR 13
TC 0
Z9 0
U1 2
U2 7
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1616-7341
EI 1616-7228
J9 OCEAN DYNAM
JI Ocean Dyn.
PD SEP
PY 2015
VL 65
IS 9-10
BP 1213
EP 1219
DI 10.1007/s10236-015-0865-3
PG 7
WC Oceanography
SC Oceanography
GA CR9DH
UT WOS:000361652900001
ER
PT J
AU Moretti, JD
Sabatini, JJ
Poret, JC
Gilbert, RA
AF Moretti, Jared D.
Sabatini, Jesse J.
Poret, Jay C.
Gilbert, Robert A., Jr.
TI Development of Sustainable, Epoxy-Bound Mg/NaNO3 Compositions for the US
Army's 40 mm Yellow Illuminant Flares
SO ACS SUSTAINABLE CHEMISTRY & ENGINEERING
LA English
DT Article
DE Formulation; Thermoset; Illuminant; Epoxy; Lifecycle risks; Laminate
ID HAND-HELD SIGNAL; GREEN-LIGHT ILLUMINANTS; PERCHLORATE-FREE; CIVILIAN
APPLICATIONS; PYROTECHNICS; MILITARY
AB We report here on the development of novel yellow-emitting pyrotechnic flares based on ground magnesium, sodium nitrate (NaNO3), and a two-part epoxy thermoset. This work was aimed to eliminate the chemical exposure risk posed by the toxic and solvent-based polyester thermoset specified for two of the U.S. Army's 40 mm yellow illuminant flares, the M585 star cluster and M583A1 star parachute signals. In particular, we describe efforts to develop a common replacement composition for both flares based on a two-part epoxy thermoset free of volatile organic chemicals (VOCs) or phthalate plasticizer. In addition, for the M583A1, we compare static burn performance of flares encased in Viton-laminated phenolic tubes to those in unlaminated tubes. A role for the Viton laminate is also proposed.
C1 [Moretti, Jared D.; Poret, Jay C.; Gilbert, Robert A., Jr.] US Army, Pyrotech Technol & Prototyping Div, RDECOM ARDEC, Picatinny Arsenal, NJ 07806 USA.
[Sabatini, Jesse J.] US Army, Res Lab, Energet Technol Branch, Aberdeen Proving Ground, MD 21005 USA.
RP Moretti, JD (reprint author), US Army, Pyrotech Technol & Prototyping Div, RDECOM ARDEC, Picatinny Arsenal, NJ 07806 USA.
EM jared.d.moretti.civ@mail.mil
FU U.S. Army
FX The authors thank the U.S. Army for funding. Special thanks are owed to
Mr. Eric A. Latalladi (ARDEC) and Mr. Stephen C. Taggart (ARDEC) for
their assistance in the preparation of all pyrotechnic items. This paper
has been approved by the U.S. government for public release;
distribution is unlimited.
NR 26
TC 0
Z9 0
U1 3
U2 6
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 2168-0485
J9 ACS SUSTAIN CHEM ENG
JI ACS Sustain. Chem. Eng.
PD SEP
PY 2015
VL 3
IS 9
BP 2232
EP 2236
DI 10.1021/acssuschemeng.5b00508
PG 5
WC Chemistry, Multidisciplinary; GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY;
Engineering, Chemical
SC Chemistry; Science & Technology - Other Topics; Engineering
GA CR1MY
UT WOS:000361090200039
ER
PT J
AU Bauer, K
Esquilin, IO
Cornier, AS
Thomas, SJ
del Rio, AIQ
Bertran-Pasarell, J
Ramirez, JOM
Diaz, C
Carlo, S
Eckels, KH
Tournay, E
Toussaint, JF
De La Barrera, R
Fernandez, S
Lyons, A
Sun, W
Innis, BL
AF Bauer, Kristen
Esquilin, Ines O.
Cornier, Alberto Santiago
Thomas, Stephen J.
del Rio, Ana I. Quintero
Bertran-Pasarell, Jorge
Ramirez, Javier O. Morales
Diaz, Clemente
Carlo, Simon
Eckels, Kenneth H.
Tournay, Elodie
Toussaint, Jean-Francois
De La Barrera, Rafael
Fernandez, Stefan
Lyons, Arthur
Sun, Wellington
Innis, Bruce L.
TI A Phase II, Randomized, Safety and Immunogenicity Trial of a Re-Derived,
Live-Attenuated Dengue Virus Vaccine in Healthy Children and Adults
Living in Puerto Rico
SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
LA English
DT Article
AB This was a double-blind, randomized, controlled, phase II clinical trial, two dose study of re-derived, live-attenuated, tetravalent dengue virus (TDEN) vaccine (two formulations) or placebo in subjects 1-50 years of age. Among the 636 subjects enrolled, 331 (52%) were primed, that is, baseline seropositive to at least one dengue virus (DENY) type. Baseline seropositivity prevalence increased with age (10% [< 2 years], 26% [2-4 years], 60% [5-20 years], and 93% [21-50 years]). Safety profiles of TDEN vaccines were similar to placebo regardless of priming status. No vaccine-related serious adverse events (SAEs) were reported. Among unprimed subjects, immunogenicity (geometric mean antibody titers [GMT] and seropositivity rates) for each DENV increased substantially in both TDEN vaccine groups with at least 74.6% seropositive for four DENV types. The TDEN vaccine candidate showed an acceptable safety and immunogenicity profile in children and adults ranging from 1 to 50 years of age, regardless of priming status.
C1 [Thomas, Stephen J.] Walter Reed Army Inst Res, Viral Dis Branch, Silver Spring, MD USA.
[Esquilin, Ines O.; Bertran-Pasarell, Jorge; Diaz, Clemente] Univ Puerto Rico, Sch Med, San Juan, PR 00936 USA.
[Cornier, Alberto Santiago; Carlo, Simon] La Concepc Hosp, Dept Mol Med, San German, PR USA.
[Cornier, Alberto Santiago] Ponce Sch Med, Dept Biochem, Ponce, PR USA.
[del Rio, Ana I. Quintero] Ctr Reumatol Pediat Puerto Rico, San Juan, PR USA.
[Ramirez, Javier O. Morales] Clin Res Puerto Rico Inc, San Juan, PR USA.
[Eckels, Kenneth H.; De La Barrera, Rafael] Walter Reed Army Inst Res, Pilot Bioprod Facil, Silver Spring, MD USA.
GSK Vaccines, Wavre, Belgium.
[Innis, Bruce L.] GSK Vaccines, King Of Prussia, PA USA.
[Bauer, Kristen] Landstuhl Reg Med Ctr, Landstuh, Germany.
[Carlo, Simon] Dept Biochem & Pediat PSMHS, Ponce, PR USA.
[Tournay, Elodie] GSK Vaccines, Vaccine Value & Hlth Sci, Biomed Data Sci, Wavre, Belgium.
[Toussaint, Jean-Francois] GSK Vaccines, Vaccine Discovery & Dev, Viral Dis Area Program, Rixensart, Belgium.
[Fernandez, Stefan] US Army Med Component Armed Forces Res Inst Med S, Bangkok, Thailand.
[Lyons, Arthur] Army Pentagon, OTSG, Washington, DC USA.
[Sun, Wellington] US FDA, Div Vaccines & Related Product Applicat, CBER, Rockville, MD 20857 USA.
RP Thomas, SJ (reprint author), Walter Reed Army Inst Res, Operat, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM kristen.m.bauer.mil@mail.mil; ines.esquilin@upr.edu; scornier@psm.edu;
stephen.j.thomas3.mil@mail.mil; anaquintero8293@msn.com;
jorge.bertran@upr.edu; morales@clinicalresearchpr.com;
clemente.diaz@upr.edu; simoncarlo3@yahoo.com;
kenneth.h.eckels.civ@mail.mil; elodie.x.tournay@gsk.com;
jean-francois.x.toussaint@gsk.com; rafael.a.delabarrera.ctr@mail.mil;
stefan.femandez@afrims.org; arthur.g.lyons.mil@mail.mil;
wellington.sun@fda.hhs.gov; bruce.2.innis@gsk.com
FU U.S. Army Medical Research and Materiel Command (Fort Detrick, MD);
GlaxoSmithKline Biologicals SA (Rixensart, Belgium)
FX This work was funded by U.S. Army Medical Research and Materiel Command
(Fort Detrick, MD) and GlaxoSmithKline Biologicals SA (Rixensart,
Belgium) under a Cooperative Research and Development Agreement.
GlaxoSmithKline Biologicals SA was involved in all stages of study
conduct, including analysis of the data, in addition to costs related to
the development of the publication of this manuscript.
NR 17
TC 2
Z9 2
U1 0
U2 0
PU AMER SOC TROP MED & HYGIENE
PI MCLEAN
PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA
SN 0002-9637
EI 1476-1645
J9 AM J TROP MED HYG
JI Am. J. Trop. Med. Hyg.
PD SEP
PY 2015
VL 93
IS 3
BP 441
EP 453
DI 10.4269/ajtmh.14-0625
PG 13
WC Public, Environmental & Occupational Health; Tropical Medicine
SC Public, Environmental & Occupational Health; Tropical Medicine
GA CR3TB
UT WOS:000361254900005
PM 26175027
ER
PT J
AU Martinez, LJ
Lin, L
Blaylock, JM
Lyons, AG
Bauer, KM
De La Barrera, R
Simmons, M
Jarman, RG
Currier, JR
Friberg, H
Danko, JR
Teneza-Mora, NC
Putnak, JR
Eckels, KH
Thomas, SJ
AF Martinez, Luis Javier
Lin, Leyi
Blaylock, Jason M.
Lyons, Arthur G.
Bauer, Kristen M.
De La Barrera, Rafael
Simmons, Monika
Jarman, Richard G.
Currier, Jeffrey R.
Friberg, Heather
Danko, Janine R.
Teneza-Mora, Nimfa C.
Putnak, J. Robert
Eckels, Kenneth H.
Thomas, Stephen J.
TI Safety and Immunogenicity of a Dengue Virus Serotype-1
Purified-Inactivated Vaccine: Results of a Phase 1 Clinical Trial
SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
LA English
DT Article
ID JAPANESE ENCEPHALITIS VACCINE; RECOMBINANT SUBUNIT; AVIDITY; CHALLENGES;
ANTIBODIES
AB We describe the results from a human clinical trial of a dengue virus serotype-1, purified-inactivated vaccine (DENV-1 PIV) adjuvanted with aluminum hydroxide. This first-in-man, Phase 1, open-label clinical trial consisted of two groups of flavivirus-naive healthy adult volunteers that received two intramuscular vaccine doses of either 2.5 mu g or 5 mu g of DENV-1 PIV administered on days 0 and 28. Following vaccination, both vaccine doses exhibited an acceptable safety profile with minimal injection site and systemic reactions. By study day 42, 2 weeks following the second vaccine dose, all volunteers in both vaccine groups developed serum-neutralizing antibodies against DENV-1. Additional testing using an enzyme-linked immunosorbent assay demonstrated induction of a humoral immune response following both vaccine doses. The DENV-1 PIV was safe and immunogenic in a small number of volunteers supporting development and further testing of a tetravalent DENY PIV formulation.
C1 [Thomas, Stephen J.] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA.
Naval Med Res Ctr, Silver Spring, MD USA.
[Martinez, Luis Javier; Lin, Leyi; Jarman, Richard G.; Currier, Jeffrey R.; Friberg, Heather; Putnak, J. Robert] Walter Reed Army Inst Res, Viral Dis Branch, Silver Spring, MD USA.
[Blaylock, Jason M.] Walter Reed Natl Mil Med Ctr, Infect Dis Clin, Bethesda, MD USA.
[Lyons, Arthur G.] 800 Army Pentagon, Off Surg Gen, Force Protect, Washington, DC USA.
[Bauer, Kristen M.] CMR 402, APO, AE 09180 USA.
[De La Barrera, Rafael; Eckels, Kenneth H.] Walter Reed Army Inst Res, Translat Med Branch, Pilot Bioprod Facil, Silver Spring, MD 20910 USA.
[Simmons, Monika; Teneza-Mora, Nimfa C.] Naval Med Res Ctr, Infect Dis Directorate, Silver Spring, MD USA.
[Danko, Janine R.] Walter Reed Natl Mil Med Ctr, Biomed Res Lab, Bethesda, MD USA.
RP Eckels, KH (reprint author), Walter Reed Army Inst Res, Translat Med Branch, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM luis.j.martinez@us.army.mil; leyi.lin.mil@mail.mil;
jason.m.blaylock.mil@mail.mil; arthur.g.lyons.mil@mail.mil;
kristen.m.bauer.mil@mail.mil; rafael.a.delabarrera.ctr@mail.mil;
monika.simmons@med.navy.mil; richard.g.jarman.mil@mail.mil;
jeffrey.r.currier.ctr@mail.mil;
heather.l.friberg-robertson.ctr@mail.mil; janine.r.danko.mil@mail.mil;
nimfa.teneza-mora@med.navy.mil; j.r.putnak.ctr@mail.mil;
kenneth.h.eckels.civ@mail.mil; stephen.j.thomas3.mil@mail.mil
FU U.S. Army Medical Research and Materiel Command (Fort Detrick, MD)
FX This work was funded by the U.S. Army Medical Research and Materiel
Command (Fort Detrick, MD).
NR 30
TC 6
Z9 6
U1 0
U2 7
PU AMER SOC TROP MED & HYGIENE
PI MCLEAN
PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA
SN 0002-9637
EI 1476-1645
J9 AM J TROP MED HYG
JI Am. J. Trop. Med. Hyg.
PD SEP
PY 2015
VL 93
IS 3
BP 454
EP 460
DI 10.4269/ajtmh.14-0819
PG 7
WC Public, Environmental & Occupational Health; Tropical Medicine
SC Public, Environmental & Occupational Health; Tropical Medicine
GA CR3TB
UT WOS:000361254900006
PM 26149862
ER
PT J
AU Saunders, DL
Garges, E
Manning, JE
Bennett, K
Schaffer, S
Kosmowski, AJ
Magill, AJ
AF Saunders, David L.
Garges, Eric
Manning, Jessica E.
Bennett, Kent
Schaffer, Sarah
Kosmowski, Andrew J.
Magill, Alan J.
TI Safety, Tolerability, and Compliance with Long-Term Antimalarial
Chemoprophylaxis in American Soldiers in Afghanistan
SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
LA English
DT Article
ID SUB-SAHARAN AFRICA; MALARIA CHEMOPROPHYLAXIS; DOUBLE-BLIND; DOXYCYCLINE
MONOHYDRATE; MEFLOQUINE; EFFICACY; PROPHYLAXIS; PLACEBO; TRIAL;
TAFENOQUINE
AB Long-term antimalarial chemoprophylaxis is currently used by deployed U.S. military personnel. Previous small, short-term efficacy studies have shown variable rates of side effects among patients taking various forms of chemoprophylaxis, though reliable safety and tolerability data on long-term use are limited. We conducted a survey of troops returning to Fort Drum, NY following a 12-month deployment to Operation Enduring Freedom, Afghanistan from 2006 to 2007. Of the 2,351 respondents, 95% reported taking at least one form of prophylaxis during their deployment, and 90% were deployed for > 10 months. Compliance with daily doxycycline was poor (60%) compared with 80% with weekly mefloquine (MQ). Adverse events (AEs) were reported by approximately 30% with both MQ and doxycycline, with 10% discontinuing doxycycline compared with 4% of MO users. Only 6% and 31% of soldiers reported use of bed nets and skin repellents, respectively. Compliance with long-term malaria prophylaxis was poor, and there were substantial tolerability issues based on these anonymous survey results, though fewer with MO than doxycycline. Given few long-term antimalarial chemoprophylaxis options, there is an unmet medical need for new anti-malarials safe for long-term use.
C1 [Saunders, David L.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand.
Walter Reed Army Inst Res, Silver Spring, MD USA.
Univ Maryland, Sch Med, Baltimore, MD 21201 USA.
Mt Div 10, Ft Drum, NY USA.
Bill & Melinda Gates Fdn, Seattle, WA USA.
RP Saunders, DL (reprint author), Armed Forces Res Inst Med Sci, 315-6 Rajvithi Rd, Bangkok 10400, Thailand.
EM david.saunders@afrims.org
FU NCATS NIH HHS [UL1 TR001425]
NR 29
TC 5
Z9 5
U1 1
U2 3
PU AMER SOC TROP MED & HYGIENE
PI MCLEAN
PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA
SN 0002-9637
EI 1476-1645
J9 AM J TROP MED HYG
JI Am. J. Trop. Med. Hyg.
PD SEP
PY 2015
VL 93
IS 3
BP 584
EP 590
DI 10.4269/ajtmh.15-0245
PG 7
WC Public, Environmental & Occupational Health; Tropical Medicine
SC Public, Environmental & Occupational Health; Tropical Medicine
GA CR3TB
UT WOS:000361254900029
PM 26123954
ER
PT J
AU Sherman, WE
Lane, AE
Mangieri, CW
Choi, YU
Faler, BJ
AF Sherman, William E.
Lane, Aaron E.
Mangieri, Christopher W.
Choi, Yong U.
Faler, Byron J.
TI Does Preoperative Weight Change Predict Postoperative Weight Loss After
Laparoscopic Sleeve Gastrectomy?
SO BARIATRIC SURGICAL PRACTICE AND PATIENT CARE
LA English
DT Article
ID Y GASTRIC BYPASS; BARIATRIC SURGERY; OUTCOMES; OBESITY
AB Background: Some institutions and insurance companies mandate a preoperative weight loss regimen prior to bariatric surgery. Previous studies suggest little to no correlation between preoperative and postoperative weight loss for laparoscopic Roux-en-Y gastric bypass (RNYGB). This study examined the impact of preoperative weight change for patients undergoing laparoscopic sleeve gastrectomy (LSG).
Materials and Methods: A retrospective analysis was performed on patients undergoing LSG at the authors' institution from 2010 to 2012. Patients were grouped based on preoperative weight gain or loss. The correlation between preoperative BMI change and postoperative BMI change was studied, as well as length of surgery.
Results: Of 141 patients with 1-year follow-up, 72 lost, six maintained, and 64 gained weight preoperatively. Percentage of excess BMI loss at 1 year was not statistically different between those who lost weight and those who gained weight. Percent change in BMI from initial visit to surgery does not correlate with change in BMI at 1 year postoperatively or with length of surgery.
Conclusions: Preoperative weight loss is not a reliable predictor of postoperative weight loss or shorter operative time after LSG. Potential patients who otherwise meet indications for LSG should not be denied based on inability to lose weight.
C1 [Sherman, William E.; Mangieri, Christopher W.; Choi, Yong U.; Faler, Byron J.] Dwight D Eisenhower Army Med Ctr, Ft Gordon, GA USA.
[Lane, Aaron E.] William Beaumont Army Med Ctr, El Paso, TX 79920 USA.
RP Sherman, WE (reprint author), MCHF SCL GSS, Ft Gordon, GA 30905 USA.
EM william.e.sherman.mil@mail.mil
NR 19
TC 2
Z9 2
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2168-023X
EI 2168-0248
J9 BARIATR SURG PRACT P
JI Bariatr. Surg. Pract. Patient Care
PD SEP 1
PY 2015
VL 10
IS 3
BP 126
EP 129
DI 10.1089/bari.2015.0023
PG 4
WC Nursing
SC Nursing
GA CR2ZZ
UT WOS:000361201000008
ER
PT J
AU Holbert, B
Tati, S
Silvestri, S
La Porta, TF
Swami, A
AF Holbert, Brett
Tati, Srikar
Silvestri, Simone
La Porta, Thomas F.
Swami, Ananthram
TI Network Topology Inference With Partial Information
SO IEEE TRANSACTIONS ON NETWORK AND SERVICE MANAGEMENT
LA English
DT Article
DE Topology inference; partial information; fault localization
ID TO-END MEASUREMENTS; ANONYMOUS ROUTERS
AB Full knowledge of the routing topology of the Internet is useful for a multitude of network management tasks. However, the full topology is often not known and is instead estimated using topology inference algorithms. Many of these algorithms use Traceroute to probe paths and then use the collected information to infer the topology. We perform real experiments and show that, in practice, routers may severely disrupt the operation of Traceroute and cause it to only provide partial information. We propose iTop, an algorithm for inferring the network topology when only partial information is available. iTop constructs a virtual topology, which overestimates the number of network components, and then repeatedly merges links in this topology to resolve it toward the structure of the true network. We perform extensive simulations to compare iTop to state-of-the-art inference algorithms. Results show that iTop significantly outperforms previous approaches and its inferred topologies are within 5% of the original networks for all considered metrics. Additionally, we show that the topologies inferred by iTop significantly improve the performance of fault localization algorithms when compared with other approaches.
C1 [Holbert, Brett; Tati, Srikar; La Porta, Thomas F.] Penn State Univ, Dept Elect & Comp Engn, University Pk, PA 16802 USA.
[Silvestri, Simone] Missouri Univ Sci & Technol, Dept Comp Sci, Rolla, MO 65409 USA.
[Swami, Ananthram] US Army Res Lab, Adelphi, MD 20783 USA.
RP Holbert, B (reprint author), Penn State Univ, Dept Elect & Comp Engn, University Pk, PA 16802 USA.
EM bdh5027@cse.psu.edu; tati@cse.psu.edu; silvestris@mst.edu;
tlp@cse.psu.edu; a.swami@ieee.org
NR 34
TC 1
Z9 2
U1 2
U2 3
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 1932-4537
J9 IEEE TRANS NETW SERV
JI IEEE Trans. Netw. Serv. Manag.
PD SEP
PY 2015
VL 12
IS 3
BP 406
EP 419
DI 10.1109/TNSM.2015.2451032
PG 14
WC Computer Science, Information Systems
SC Computer Science
GA CR3DI
UT WOS:000361210300007
ER
PT J
AU Capozzola, C
Huebner, A
Irwin, J
Keene, JD
Kennedy, R
Neiberg, M
Ortiz, SR
Williams, C
Winter, J
AF Capozzola, Christopher
Huebner, Andrew
Irwin, Julia
Keene, Jennifer D.
Kennedy, Ross
Neiberg, Michael
Ortiz, Stephen R.
Williams, Chad
Winter, Jay
TI Interchange: World War I
SO JOURNAL OF AMERICAN HISTORY
LA English
DT Article
ID GREAT-WAR; 1ST-WORLD-WAR; AMERICANS
C1 [Capozzola, Christopher] MIT, Hist, Cambridge, MA 02139 USA.
[Huebner, Andrew] Univ Alabama, Hist, Tuscaloosa, AL 35487 USA.
[Irwin, Julia] Univ S Florida, Hist, Tampa, FL 33620 USA.
[Keene, Jennifer D.] Chapman Univ, Hist, Orange, CA USA.
[Kennedy, Ross] Illinois State Univ, Hist, Normal, IL 61761 USA.
[Neiberg, Michael] US Army War Coll, Hist, Carlisle, PA USA.
[Ortiz, Stephen R.] SUNY Binghamton, Hist, Binghamton, NY USA.
[Williams, Chad] Brandeis Univ, African & Afroamer Studies Dept, Waltham, MA 02254 USA.
[Winter, Jay] Yale Univ, Hist, New Haven, CT 06520 USA.
RP Capozzola, C (reprint author), MIT, Hist, Cambridge, MA 02139 USA.
EM capozzol@mit.edu; ahuebner@ua.edu; juliai@usf.edu; keene@chapman.edu;
rkenned@ilstu.edu; neiberg102@gmail.com; sortiz@binghamton.edu;
chadw@brandeis.edu
NR 214
TC 1
Z9 1
U1 0
U2 3
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0021-8723
EI 1945-2314
J9 J AM HIST
JI J. Am. Hist.
PD SEP
PY 2015
VL 102
IS 2
BP 463
EP 499
DI 10.1093/jahist/jav474
PG 37
WC History
SC History
GA CR5MA
UT WOS:000361385700005
ER
PT J
AU Zheng, JX
Hou, YY
Duan, YD
Song, XH
Wei, Y
Liu, TC
Hu, JT
Guo, H
Zhuo, ZQ
Liu, LL
Chang, Z
Wang, XW
Zherebetskyy, D
Fang, YY
Lin, Y
Xu, K
Wang, LW
Wu, YP
Pan, F
AF Zheng, Jiaxin
Hou, Yuyang
Duan, Yandong
Song, Xiaohe
Wei, Yi
Liu, Tongchao
Hu, Jiangtao
Guo, Hua
Zhuo, Zengqing
Liu, Lili
Chang, Zheng
Wang, Xiaowei
Zherebetskyy, Danylo
Fang, Yanyan
Lin, Yuan
Xu, Kang
Wang, Lin-Wang
Wu, Yuping
Pan, Feng
TI Janus Solid-Liquid Interface Enabling Ultrahigh Charging and Discharging
Rate for Advanced Lithium-Ion Batteries
SO NANO LETTERS
LA English
DT Article
DE LiFePO4; rate performance; aqueous electrolyte; organic electrolyte;
solid-liquid interface; ab initio calculations
ID INITIO MOLECULAR-DYNAMICS; TOTAL-ENERGY CALCULATIONS; AUGMENTED-WAVE
METHOD; RECHARGEABLE BATTERIES; ELECTROLYTE-SOLUTIONS; LIFEPO4 CATHODES;
RATE CAPABILITY; PARTICLE-SIZE; BASIS-SET; STORAGE
AB LiFePO4 has long been held as one of the most promising battery cathode for its high energy storage capacity. Meanwhile, although extensive studies have been conducted on the interfacial chemistries in Li-ion batteries,(1-3) little is known on the atomic level about the solid-liquid interface of LiFePO4/electrolyte. Here, we report battery cathode consisted with nanosized LiFePO4 particles in aqueous electrolyte with an high charging and discharging rate of 600 C (3600/600 = 6 s charge time, 1 C = 170 mAh g(-)1) reaching 72 mAh g(-1) energy storage (42% of the theoretical capacity). By contrast, the accessible capacity sharply decreases to 20 mAh g(-1) at 200 C in organic electrolyte. After a comprehensive electrochemistry tests and ab initio calculations of the LiFePO4-H2O and LiFePO4-EC (ethylene carbonate) systems, we identified the transient formation of a Janus hydrated interface in the LiFePO4-H2O system, where the truncated symmetry of solid LiFePO4 surface is compensated by the chemisorbed H2O molecules, forming a half-solid (LiFePO4) and half-liquid (H2O) amphiphilic coordination environment that eases the Li desolvation process near the surface, which makes a fast Li-ion transport across the solid/liquid interfaces possible.
C1 [Zheng, Jiaxin; Song, Xiaohe; Wei, Yi; Liu, Tongchao; Hu, Jiangtao; Guo, Hua; Zhuo, Zengqing; Pan, Feng] Peking Univ, Shenzhen Grad Sch, Sch Adv Mat, Shenzhen 518055, Peoples R China.
[Hou, Yuyang; Wu, Yuping] Nanjing Tech Univ, Coll Energy, Nanjing 211816, Jiangsu, Peoples R China.
[Hou, Yuyang; Liu, Lili; Chang, Zheng; Wang, Xiaowei; Wu, Yuping] Fudan Univ, Dept Chem, New Energy & Mat Lab, Shanghai 200433, Peoples R China.
[Hou, Yuyang; Liu, Lili; Chang, Zheng; Wang, Xiaowei; Wu, Yuping] Fudan Univ, Shanghai Key Lab Mol Catalysis & Innovat Mat, Shanghai 200433, Peoples R China.
[Zherebetskyy, Danylo; Wang, Lin-Wang] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Div Mat Sci, Berkeley, CA 94720 USA.
[Fang, Yanyan; Lin, Yuan] Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, Key Lab Photochem, Beijing 100190, Peoples R China.
[Xu, Kang] US Army, Res Lab, Electrochem Branch, Adelphi, MD 20783 USA.
RP Wu, YP (reprint author), Nanjing Tech Univ, Coll Energy, Nanjing 211816, Jiangsu, Peoples R China.
EM wuyp@fudan.edu.cn; panfeng@pkusz.edu.cn
RI Duan, Yandong/I-4206-2013; Wu, Yuping/H-1593-2011; lin, yuan/G-9390-2013
OI Wu, Yuping/0000-0002-0833-1205; lin, yuan/0000-0003-3410-3588
FU National Project for EV Batteries (OptimumNano, Shenzhen) [20121110];
National Distinguished Young Scientists of China [51425301]; STCSM
[12JC1401200]; Guangdong Innovation Team Project [2013N080]; Shenzhen
Science and Technology Research Grant [ZDSY20130331145131323,
CXZZ20120829172325895]; Office of Science (SC), Basic Energy Science
(BES)/Materials Science and Engineering Division (MSED) of the U.S.
Department of Energy (DOE) [DE-AC02-05CH11231]; ShenZhen National Super
Computing Center
FX The research was financially supported by National Project for EV
Batteries (20121110, OptimumNano, Shenzhen), National Distinguished
Young Scientists of China (51425301), STCSM (12JC1401200), Guangdong
Innovation Team Project (No. 2013N080), and Shenzhen Science and
Technology Research Grant (No. ZDSY20130331145131323 and
CXZZ20120829172325895). L.W.W. is supported through the Theory of
Material project by the Director, Office of Science (SC), Basic Energy
Science (BES)/Materials Science and Engineering Division (MSED) of the
U.S. Department of Energy (DOE) under the contract No.
DE-AC02-05CH11231. Additionally, we acknowledge the support of ShenZhen
National Super Computing Center.
NR 53
TC 12
Z9 12
U1 21
U2 137
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1530-6984
EI 1530-6992
J9 NANO LETT
JI Nano Lett.
PD SEP
PY 2015
VL 15
IS 9
BP 6102
EP 6109
DI 10.1021/acs.nanolett.5b02379
PG 8
WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience &
Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied;
Physics, Condensed Matter
SC Chemistry; Science & Technology - Other Topics; Materials Science;
Physics
GA CR3SF
UT WOS:000361252700068
PM 26305572
ER
PT J
AU Karamian, SA
Carroll, JJ
Aksenov, NV
Albin, YA
Belov, AG
Bozhikov, GA
Dmitriev, SN
Starodub, GY
AF Karamian, S. A.
Carroll, J. J.
Aksenov, N. V.
Albin, Yu. A.
Belov, A. G.
Bozhikov, G. A.
Dmitriev, S. N.
Starodub, G. Ya.
TI Production of isotopes and isomers with irradiation of Z=47-50 targets
by 23-MeV bremsstrahlung
SO PHYSICS OF ATOMIC NUCLEI
LA English
DT Article
ID HEAVY-NUCLEI; DEPLETION; YIELD
AB The irradiations of Ag to Sn targets by bremsstrahlung generated with 23-MeV electron beams are performed at the MT-25 microtron. Gamma spectra of the induced activities have been measured and the yields of all detected radionuclides and isomers are carefully measured and analyzed. A regular dependence of yields versus changed reaction threshold is confirmed. Many isomers are detected and the suppression of the production probability is observed with growing product spin. Special peculiarities for the isomer-to-ground state ratios were deduced for the (106m) Ag, (108m) Ag, (113m) In, (115m) In, and (123m) Sn isomers. The production of such nuclides as (108m) Ag, (115m) In, (117g) In, and (113m) Cd is of interest for applications, especially when economic methods are available.
C1 [Karamian, S. A.; Aksenov, N. V.; Albin, Yu. A.; Belov, A. G.; Bozhikov, G. A.; Dmitriev, S. N.; Starodub, G. Ya.] Joint Inst Nucl Res, Dubna, Russia.
[Carroll, J. J.] US Army Res Lab, Baltimore, MD USA.
RP Karamian, SA (reprint author), Joint Inst Nucl Res, Dubna, Russia.
EM karamian@nrmail.jinr.ru
FU RFBR [14-03-00745a]
FX The reported study was partially supported by RFBR, research project no.
14-03-00745a.
NR 23
TC 0
Z9 0
U1 3
U2 3
PU MAIK NAUKA/INTERPERIODICA/SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013-1578 USA
SN 1063-7788
EI 1562-692X
J9 PHYS ATOM NUCL+
JI Phys. Atom. Nuclei
PD SEP
PY 2015
VL 78
IS 6
BP 757
EP 766
DI 10.1134/S1063778815060113
PG 10
WC Physics, Nuclear; Physics, Particles & Fields
SC Physics
GA CR6GY
UT WOS:000361444500007
ER
PT J
AU Lim, L
Ali, RSM
Yip, JT
Qian, J
Tan, BH
Chua, A
Yeung, BK
Shi, PY
Diagana, TT
Ubalee, R
Bifani, JP
AF Lim, L.
Ali, R. S. Made
Yip, J. T.
Qian, J.
Tan, B. H.
Chua, A.
Yeung, B. K.
Shi, P. Y.
Diagana, T. T.
Ubalee, R.
Bifani, J. P.
TI Development of an Anopheles vector and tools to study Plasmodium
cynomolgi, a surrogate for P. vivax
SO TROPICAL MEDICINE & INTERNATIONAL HEALTH
LA English
DT Meeting Abstract
C1 [Lim, L.; Ali, R. S. Made; Yip, J. T.; Qian, J.; Tan, B. H.; Chua, A.; Yeung, B. K.; Shi, P. Y.; Diagana, T. T.; Bifani, J. P.] Novartis Inst Trop Dis, Dis Biol, Singapore, Singapore.
[Ubalee, R.] Armed Forces Res Inst Med Sci, Malariol, Bangkok 10400, Thailand.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1360-2276
EI 1365-3156
J9 TROP MED INT HEALTH
JI Trop. Med. Int. Health
PD SEP
PY 2015
VL 20
SU 1
SI SI
BP 13
EP 13
PG 1
WC Public, Environmental & Occupational Health; Tropical Medicine
SC Public, Environmental & Occupational Health; Tropical Medicine
GA CQ7BW
UT WOS:000360758800031
ER
PT J
AU Payne, RO
Milne, KH
Elias, SC
Edwards, NJ
Douglas, AD
Brown, RE
Silk, SE
Biswas, S
Miura, K
Roberts, R
Rampling, TW
Venkatraman, N
Hodgson, SH
Labbe, GM
Halstead, FD
Ockenhouse, CF
Kathcart, AK
Qabar, AN
Waters, NC
Soisson, LA
Woods, C
Birkett, AJ
Long, CA
Vekemans, J
Diggs, CL
Hill, AVS
Lawrie, AM
Dutta, S
Draper, SJ
AF Payne, R. O.
Milne, K. H.
Elias, S. C.
Edwards, N. J.
Douglas, A. D.
Brown, R. E.
Silk, S. E.
Biswas, S.
Miura, K.
Roberts, R.
Rampling, T. W.
Venkatraman, N.
Hodgson, S. H.
Labbe, G. M.
Halstead, F. D.
Ockenhouse, C. F.
Kathcart, A. K.
Qabar, A. N.
Waters, N. C.
Soisson, L. A.
Woods, C.
Birkett, A. J.
Long, C. A.
Vekemans, J.
Diggs, C. L.
Hill, A. V. S.
Lawrie, A. M.
Dutta, S.
Draper, S. J.
TI Assessment of FMP2.1/AS01B, an asexual blood-stage malaria vaccine, in a
phase I/II a clinical trial using blood-stage controlled human malaria
infection
SO TROPICAL MEDICINE & INTERNATIONAL HEALTH
LA English
DT Meeting Abstract
C1 [Payne, R. O.; Milne, K. H.; Elias, S. C.; Edwards, N. J.; Douglas, A. D.; Brown, R. E.; Silk, S. E.; Biswas, S.; Roberts, R.; Rampling, T. W.; Venkatraman, N.; Hodgson, S. H.; Labbe, G. M.; Halstead, F. D.; Hill, A. V. S.; Lawrie, A. M.; Draper, S. J.] Univ Oxford, Jenner Inst, Oxford, England.
[Miura, K.; Long, C. A.] NIH, Lab Malaria & Vector Res, Washington, DC USA.
[Ockenhouse, C. F.; Kathcart, A. K.; Qabar, A. N.; Waters, N. C.; Dutta, S.] Walter Reed Army Inst Res, Mil Malaria Res Program, Silver Spring, MD USA.
[Soisson, L. A.; Diggs, C. L.] US Agcy Int Dev, Washington, DC 20523 USA.
[Woods, C.; Birkett, A. J.] PATH Malaria Vaccine Initiat, Washington, DC USA.
[Vekemans, J.] GSK, Rixensart, Belgium.
NR 0
TC 0
Z9 0
U1 1
U2 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1360-2276
EI 1365-3156
J9 TROP MED INT HEALTH
JI Trop. Med. Int. Health
PD SEP
PY 2015
VL 20
SU 1
SI SI
BP 22
EP 22
PG 1
WC Public, Environmental & Occupational Health; Tropical Medicine
SC Public, Environmental & Occupational Health; Tropical Medicine
GA CQ7BW
UT WOS:000360758800052
ER
PT J
AU Henry, B
Morizot, G
Blum, J
Van der Auwera, G
Clerinx, J
Harms, G
Bart, A
Armstrong, M
Ravel, C
Robert-Gangneux, F
Gangneux, JP
Felger, I
Bailey, M
Grogl, M
Lockwood, D
Buffet, P
AF Henry, B.
Morizot, G.
Blum, J.
Van der Auwera, G.
Clerinx, J.
Harms, G.
Bart, A.
Armstrong, M.
Ravel, C.
Robert-Gangneux, F.
Gangneux, J. -P.
Felger, I.
Bailey, M.
Groegl, M.
Lockwood, D.
Buffet, P.
CA LeishMan Network
TI Worldwide diversity of leishmaniasis: harmonized collection of data and
isolates by the European "LeishMan" network: the LeishMan Network
SO TROPICAL MEDICINE & INTERNATIONAL HEALTH
LA English
DT Meeting Abstract
C1 [Henry, B.] Univ Paris 05, Hop Necker Enfants Malad, APHP, Serv Malad Infect & Trop,Sorbonne Paris Cite,Ctr, B-2000 Paris, France.
[Morizot, G.] Inst Pasteur, Invest Clin & Acces Ressources Biol, D-13353 Paris, France.
[Blum, J.; Felger, I.] Swiss Trop & Publ Hlth Inst, NL-1105 AZ Basel, Switzerland.
[Van der Auwera, G.; Clerinx, J.] Inst Trop Med, Antwerp NW1 0PE, Belgium.
[Harms, G.] Charite, Inst Tropenmed & Int Gesundheit, Berlin, Germany.
[Bart, A.] Univ Amsterdam, Acad Med Ctr, Amsterdam, Netherlands.
[Armstrong, M.; Lockwood, D.] Hosp Trop Dis, London, England.
[Ravel, C.] CHU Montpellier, Fac Med Montpellier, Montpellier, France.
[Robert-Gangneux, F.; Gangneux, J. -P.] Univ Rennes 1, CHU Rennes, Rennes, France.
[Bailey, M.] Royal Ctr Def Med, Birmingham, W Midlands, England.
[Groegl, M.] Walter Reed Army Inst Res, Silver Spring, MD USA.
[Buffet, P.] Univ Paris 06, Sorbonne Univ, Hop La Pitie Salpetriere, Serv Parasitol & Mycol, Paris, France.
RI Robert-Gangneux, Florence/I-4692-2015; Bart, Aldert/B-9520-2008
OI Bart, Aldert/0000-0001-6605-6347
NR 0
TC 0
Z9 0
U1 0
U2 3
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1360-2276
EI 1365-3156
J9 TROP MED INT HEALTH
JI Trop. Med. Int. Health
PD SEP
PY 2015
VL 20
SU 1
SI SI
BP 35
EP 35
PG 1
WC Public, Environmental & Occupational Health; Tropical Medicine
SC Public, Environmental & Occupational Health; Tropical Medicine
GA CQ7BW
UT WOS:000360758800084
ER
PT J
AU Lurchachaiwong, W
McCardle, W
Chan, TC
Schuster, AL
Richards, AL
AF Lurchachaiwong, Woradee
McCardle, Wesley
Chan, Teik-Chye
Schuster, Anthony L.
Richards, Allen L.
TI Development of an Orientia tsutsugamushi Lc-1 Murine Intraperitoneal
Challenge Model for Scrub Typhus: Determination of Murine Lethal Dose
(MuLD(50)), Tissue Bacterial Loads, and Clinical Outcomes
SO VECTOR-BORNE AND ZOONOTIC DISEASES
LA English
DT Article
DE Tsutsugamushi; Scrub typhus; Rickettsia; Chigger mite; Modeling
ID LABORATORY MICE; INFECTIONS; THAILAND; ILLNESS
AB Currently, no vaccine has been developed to protect humans from naturally acquired heterologous Orientia tsutsugamushi infections. To enhance the validity of vaccine candidates, we are developing a murine chigger challenge model with the O. tsutsugamushi Lc-1-infected Leptotrombidium chiangraiensis Line-1. To this end, an intraperitoneal (i.p.) murine challenge model using an O. tsutsugamushi Lc-1 isolate was developed for eventual validation of the chigger challenge model. We have determined that the murine lethal dose that kills 50% of the challenged mice (MuLD(50)) of a liver/spleen homogenate developed from O. tsutsugamushi Lc-1-infected ICR Swiss mice to be 10(-6.9). Employing different inoculum doses of this homogenate, the bacterial load using quantitative real-time PCR (qPCR) was determined to range from 60 to 1.6 x 10(5) genome equivalent copies (GEC)/mu L of liver and 33.4 to 2.2 x 10(5) GEC/mu L of spleen tissue. The clinical outcomes relative to homogenate dose levels followed a dose-dependent pattern. The successful development and characterization of the O. tsutsugamushi Lc-1 i.p. challenge model will assist in the development and validation of a mouse chigger challenge scrub typhus model.
C1 [Lurchachaiwong, Woradee; McCardle, Wesley; Schuster, Anthony L.] Armed Forces Res Inst Med Sci, Dept Entomol, US Army Med Component, Bangkok 10400, Thailand.
[Chan, Teik-Chye; Richards, Allen L.] Naval Med Res Ctr, Viral & Rickettsial Dis Dept, Silver Spring, MD USA.
[Richards, Allen L.] Uniformed Serv Univ Hlth Sci, Prevent Med & Biometr Dept, Bethesda, MD 20814 USA.
RP Lurchachaiwong, W (reprint author), AFRIMS, Dept Enter Dis, 315-6 Ratchawithi Rd, Bangkok 10400, Thailand.
EM WoradeeL.fsn@afrims.org
NR 26
TC 1
Z9 1
U1 1
U2 3
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1530-3667
EI 1557-7759
J9 VECTOR-BORNE ZOONOT
JI Vector-Borne Zoonotic Dis.
PD SEP 1
PY 2015
VL 15
IS 9
BP 539
EP 544
DI 10.1089/vbz.2015.1773
PG 6
WC Public, Environmental & Occupational Health; Infectious Diseases
SC Public, Environmental & Occupational Health; Infectious Diseases
GA CR5MM
UT WOS:000361387200004
PM 26378973
ER
PT J
AU Kragh, JE
Aden, JK
Walters, TJ
Baer, DG
Nam, JJ
Berry, KA
Mase, VJ
Dubick, MA
Wade, CE
Blackbourne, LH
AF Kragh, John E., Jr.
Aden, James K., III
Walters, Thomas J.
Baer, David G.
Nam, Jason J.
Berry, Keith A.
Mase, Vincent J.
Dubick, Michael A.
Wade, Charles E.
Blackbourne, Lorne H.
TI Confounders, Mediators, and Selection Bias Reply
SO ANNALS OF EMERGENCY MEDICINE
LA English
DT Letter
ID TOURNIQUET USE; TRAUMA; SURVIVAL
C1 [Kragh, John E., Jr.; Aden, James K., III; Walters, Thomas J.; Baer, David G.] US Army Inst Surg Res, Jbsa Ft Sam Houston, TX 78234 USA.
[Nam, Jason J.] Walter Reed Natl Mil Med Ctr, Bethesda, MD USA.
[Berry, Keith A.] Penn State Univ, Milton S Hershey Med Ctr, Hershey, PA 17033 USA.
[Mase, Vincent J.] Brian Allgood Army Community Hosp, Seoul, South Korea.
[Dubick, Michael A.] US Army Inst Surg Res, Damage Control Resuscitat, Jbsa Ft Sam Houston, TX USA.
[Wade, Charles E.] Univ Texas Med Sch Houston, Houston, TX USA.
[Blackbourne, Lorne H.] San Antonio Mil Med Ctr, Jbsa Ft Sam Houston, TX USA.
RP Kragh, JE (reprint author), US Army Inst Surg Res, Jbsa Ft Sam Houston, TX 78234 USA.
NR 6
TC 1
Z9 1
U1 0
U2 0
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0196-0644
J9 ANN EMERG MED
JI Ann. Emerg. Med.
PD SEP
PY 2015
VL 66
IS 3
BP 340
EP 341
DI 10.1016/j.annemergmed.2015.04.024
PG 2
WC Emergency Medicine
SC Emergency Medicine
GA CR1JW
UT WOS:000361082100031
PM 26304258
ER
PT J
AU Michaud, S
Boncristiani, HF
Gouw, JW
Strand, MK
Pettis, J
Rueppell, O
Foster, LJ
AF Michaud, Sarah
Boncristiani, Humberto F., Jr.
Gouw, Joost W.
Strand, Micheline K.
Pettis, Jeffrey
Rueppell, Olav
Foster, Leonard J.
TI Response of the honey bee (Apis mellifera) proteome to Israeli acute
paralysis virus (IAPV) infection
SO CANADIAN JOURNAL OF ZOOLOGY
LA English
DT Article
DE Apis mellifera; Israeli acute paralysis virus; Dicistroviridae; mass
spectrometry; proteomics
ID COLONY COLLAPSE DISORDER; QUANTITATIVE PROTEOMICS; VARROA-DESTRUCTOR;
IMMUNE; RNA; DICISTROVIRUSES; PATHOGEN; RIBOSOME; REVEALS; HOST
AB Recent declines in honey bee (Apis mellifera L., 1758) populations worldwide have spurred significant research into the impact of pathogens on colony health. The role of the Israeli acute paralysis virus (IAPV) on hive mortality has become of particular concern since being correlated with colony losses. However, the molecular interactions between IAPV and its host remain largely unknown. To investigate changes in host protein expression during IAPV infection, mass-spectrometry-based quantitative proteomics was used to compare IAPV-infected and healthy pupae. Proteins whose expression levels changed significantly during infection were identified and functional analysis was performed to determine host systems and pathways perturbed by IAPV infection. Among the A. mellifera proteins most affected by IAPV, those involving translation and the ubiquitin-proteasome pathway were most highly enriched and future investigation of these pathways will be useful in identifying host proteins required for infection. This analysis represents an important first step towards understanding the honey bee host response to IAPV infection through the systems-level analysis of protein expression.
C1 [Michaud, Sarah; Gouw, Joost W.; Foster, Leonard J.] Univ British Columbia, Ctr High Throughput Biol, Dept Biochem & Mol Biol, Vancouver, BC V6T 1Z4, Canada.
[Boncristiani, Humberto F., Jr.; Rueppell, Olav] Univ N Carolina, Dept Biol, Greensboro, NC 27403 USA.
[Strand, Micheline K.] US Army, Res Off, Div Life Sci, Res Triangle Pk, NC 27709 USA.
[Pettis, Jeffrey] USDA ARS, Bee Res Lab, Beltsville, MD 20705 USA.
RP Foster, LJ (reprint author), Univ British Columbia, Ctr High Throughput Biol, Dept Biochem & Mol Biol, 2125 East Mall, Vancouver, BC V6T 1Z4, Canada.
EM foster@chibi.ubc.ca
OI Rueppell, Olav/0000-0001-5370-4229
FU Natural Sciences and Engineering Research Council of Canada (NSERC);
Genome Canada; Genome British Columbia; British Columbia Honey Producers
Association through the Boone-Hodgson-Wilkinson Fund; Canadian Honey
Council through the Canadian Bee Research Fund; Canadian Association of
Professional Apiculturists through the Canadian Bee Research Fund;
British Columbia Blueberry Council; British Columbia Cranberry Marketing
Association; University of British Columbia; Agri-Food Canada's
Advancing Canadian Agriculture and Agri-Food (ACAAF) program; Canada
Foundation for Innovation; British Columbia Knowledge Development Fund;
British Columbia Proteomics Network; Canadian Institutes of Health
Research Fellowship; National Academy of Sciences; US National Institute
of Food and Agriculture AFRI grant [2010-65104-20533]
FX We thank members of our respective groups for continual support. This
work was supported by funding from the Natural Sciences and Engineering
Research Council of Canada (NSERC), Genome Canada, Genome British
Columbia, the British Columbia Honey Producers Association through the
Boone-Hodgson-Wilkinson Fund, the Canadian Honey Council and Canadian
Association of Professional Apiculturists through the Canadian Bee
Research Fund, the British Columbia Blueberry Council, the British
Columbia Cranberry Marketing Association, The University of British
Columbia and Agri-Food Canada's Advancing Canadian Agriculture and
Agri-Food (ACAAF) program. The latter is part of a Collective Outcome
project with the cooperation of the Investment Agriculture Foundation of
British Columbia, the Alberta Agriculture and Food Council, the Manitoba
Rural Adaptation Council, the Ontario Agricultural Adaptation Council,
the Conseil pour le developpement de l'agriculture du Quebec, and
Agri-Futures Nova Scotia. Mass spectrometry infrastructure used in this
project was supported by the Canada Foundation for Innovation, the
British Columbia Knowledge Development Fund, and the British Columbia
Proteomics Network. L.J.F. is the Canada Research Chair in Quantitative
Proteomics. J.W.G. was supported by a Canadian Institutes of Health
Research Fellowship. Additional support was provided by the National
Academy of Sciences in form of a NRC fellowship grant to H.F.B. and by
the US National Institute of Food and Agriculture AFRI grant
(#2010-65104-20533) to O.R. The funders had no role in the study design,
data collection and analysis, decision to publish, or preparation of the
manuscript.
NR 42
TC 4
Z9 4
U1 5
U2 46
PU CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 0008-4301
EI 1480-3283
J9 CAN J ZOOL
JI Can. J. Zool.
PD SEP
PY 2015
VL 93
IS 9
SI SI
BP 711
EP 720
DI 10.1139/cjz-2014-0181
PG 10
WC Zoology
SC Zoology
GA CQ9PK
UT WOS:000360946900005
ER
PT J
AU Platteborze, PL
Wilhelms, KW
AF Platteborze, Peter L.
Wilhelms, Kelly W.
TI Request for Uric Acid Analysis on an Iced Specimen
SO CLINICAL CHEMISTRY
LA English
DT Editorial Material
C1 Brooke Army Med Ctr, JBSA FSH, Dept Pathol, Core Reference Lab, Ft Sam Houston, TX 78234 USA.
Brooke Army Med Ctr, JBSA FSH, Area Lab Serv, Ft Sam Houston, TX 78234 USA.
RP Platteborze, PL (reprint author), Brooke Army Med Ctr, JBSA FSH, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
EM peter.platteborze@gmail.com
NR 3
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CLINICAL CHEMISTRY
PI WASHINGTON
PA 2101 L STREET NW, SUITE 202, WASHINGTON, DC 20037-1526 USA
SN 0009-9147
EI 1530-8561
J9 CLIN CHEM
JI Clin. Chem.
PD SEP
PY 2015
VL 61
IS 9
BP 1212
EP 1213
DI 10.1373/clinchem.2015.238808
PG 2
WC Medical Laboratory Technology
SC Medical Laboratory Technology
GA CR1TD
UT WOS:000361107000017
PM 26319454
ER
PT J
AU Flick, D
Flick, R
AF Flick, David
Flick, Renee
TI Chronic Exertional Compartment Syndrome Testing
SO CURRENT SPORTS MEDICINE REPORTS
LA English
DT Review
ID NEAR-INFRARED SPECTROSCOPY; ELECTROMYOGRAPHY-DETERMINED MEASUREMENTS;
CHRONIC LEG PAIN; INTRACOMPARTMENTAL PRESSURE; INTRAMUSCULAR PRESSURE;
NEUROMUSCULAR FUNCTION; DIAGNOSTIC-CRITERIA; MUSCLE; ULTRASOUND;
EXERCISE
AB Chronic exertional compartment syndrome is diagnosed based on historical and physical exam findings combined with elevated intracompartmental pressures. Direct static testing with a large bore needle device is the most common instrument used for diagnosis. Based on the most recent systematic reviews, there is poor evidence for the traditional diagnostic pressures used in practice with no standardization of the procedure. New research has introduced a standardized approach with dynamic testing of the limb with transducer-tipped catheters. Less invasive methods of testing using radiologic techniques are currently under investigation. A detailed understanding of the anatomy and physiology of the limb is paramount in executing a safe and accurate procedure.
C1 [Flick, David; Flick, Renee] Tripler Army Med Ctr, Honolulu, HI 96859 USA.
RP Flick, D (reprint author), Tripler Army Med Ctr, 1 Jarrett White Rd, Honolulu, HI 96859 USA.
EM david.m.flick.mil@mail.mil
NR 47
TC 0
Z9 0
U1 2
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1537-890X
EI 1537-8918
J9 CURR SPORT MED REP
JI Curr. Sport. Med. Rep.
PD SEP-OCT
PY 2015
VL 14
IS 5
BP 380
EP 385
DI 10.1249/JSR.0000000000000187
PG 6
WC Sport Sciences
SC Sport Sciences
GA CR1TS
UT WOS:000361108600012
PM 26359839
ER
PT J
AU O'Brien, C
Castellani, JW
Muza, SR
AF O'Brien, Catherine
Castellani, John W.
Muza, Stephen R.
TI Acute Hypobaric Hypoxia Effects on Finger Temperature During and After
Local Cold Exposure
SO HIGH ALTITUDE MEDICINE & BIOLOGY
LA English
DT Article
DE altitude; cold-induced vasodilation; rewarming
ID INDUCED VASODILATION; COOLING TEST; AIR-TEMPERATURE; HEALTHY HUMANS;
HIGH-ALTITUDES; RESPONSES; REPRODUCIBILITY; HYPEROXIA; VESSELS; INJURY
AB O'Brien, Catherine, John W. Castellani, and Stephen R. Muza. Acute hypobaric hypoxia effects on finger temperature during and after local cold exposure. High Alt Med Biol 16:244-250, 2015.Mountain environments have combined stressors of lower ambient temperature and hypoxia. Cold alone can reduce finger temperature, resulting in discomfort, impaired dexterity, and increased risk of cold injury. Whether hypobaric hypoxia exacerbates these effects is unclear. To examine this, finger temperature responses to two cold water immersion tests were measured at sea level (SL, 99kPa), 3000m (70kPa), and 4675m (56kPa) at the same air temperature (22 degrees-23 degrees C). Nine males sat quietly for 30min, then completed the tests in balanced order. For the cold-induced vasodilation (CIVD) test, middle finger pad temperature was measured during immersion in 4 degrees C water for 30min. For the Rewarming test, finger temperature was measured for 30min following a 5min hand immersion in 16 degrees C water. Average oxygen saturation was 98.6% during SL, 90.7% at 3000m, and 75.8% at 4657m. Mean finger temperature during the CIVD test (7.1 degrees C) was similar among trials. There was no difference in CIVD parameters of nadir, apex, or mean finger temperatures; however both onset and apex times were earlier at 3000m, compared to SL (0.6min and 1.6min, respectively). These differences did not persist at 4657m. Rewarming after hand immersion was similar among trials, reaching 22.7 degrees C after 30min, compared to an initial finger temperature of 29.3 degrees C. The results of this study provide no evidence that hypobaric hypoxia increases risk of cold injury. Previous findings of blunted finger temperatures at altitude are likely due to the lower ambient temperature that typically occurs at higher elevations.
C1 [O'Brien, Catherine; Castellani, John W.; Muza, Stephen R.] US Army, Thermal & Mt Med Div, Environm Med Res Inst, Natick, MA 01760 USA.
RP O'Brien, C (reprint author), US Army, Thermal & Mt Med Div, Environm Med Res Inst, Kansas St, Natick, MA 01760 USA.
EM catherine.obrien2.civ@mail.mil
NR 34
TC 1
Z9 2
U1 4
U2 6
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1527-0297
EI 1557-8682
J9 HIGH ALT MED BIOL
JI High Alt. Med. Biol.
PD SEP 1
PY 2015
VL 16
IS 3
BP 244
EP 250
PG 7
WC Biophysics; Public, Environmental & Occupational Health; Sport Sciences
SC Biophysics; Public, Environmental & Occupational Health; Sport Sciences
GA CQ5RI
UT WOS:000360662800027
PM 26334585
ER
PT J
AU Hoge, CW
AF Hoge, Charles W.
TI Measuring the Long-term Impact of War-Zone Military Service Across
Generations and Changing Posttraumatic Stress Disorder Definitions
SO JAMA PSYCHIATRY
LA English
DT Editorial Material
ID AFGHANISTAN; PREVALENCE; DSM-5; PTSD; IRAQ
C1 Walter Reed Army Inst Res, Ctr Psychiat & Neurosci, Silver Spring, MD 20910 USA.
RP Hoge, CW (reprint author), Walter Reed Army Inst Res, Ctr Psychiat & Neurosci, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM charles.w.hoge.civ@mail.mil
NR 8
TC 2
Z9 2
U1 1
U2 7
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 2168-622X
EI 2168-6238
J9 JAMA PSYCHIAT
JI JAMA Psychiatry
PD SEP
PY 2015
VL 72
IS 9
BP 861
EP 862
DI 10.1001/jamapsychiatry.2015.1066
PG 2
WC Psychiatry
SC Psychiatry
GA CR0DE
UT WOS:000360987600002
PM 26200673
ER
PT J
AU Ursano, RJ
Kessler, RC
Stein, MB
Naifeh, JA
Aliaga, PA
Fullerton, CS
Sampson, NA
Kao, TC
Colpe, LJ
Schoenbaum, M
Cox, KL
Heeringa, SG
AF Ursano, Robert J.
Kessler, Ronald C.
Stein, Murray B.
Naifeh, James A.
Aliaga, Pablo A.
Fullerton, Carol S.
Sampson, Nancy A.
Kao, Tzu-Cheg
Colpe, Lisa J.
Schoenbaum, Michael
Cox, Kenneth L.
Heeringa, Steven G.
CA Army Study Assess Risk Resilience
TI Suicide Attempts in the US Army During the Wars in Afghanistan and Iraq,
2004 to 2009
SO JAMA PSYCHIATRY
LA English
DT Article
ID ACTIVE-DUTY PERSONNEL; ASSESS RISK; MENTAL-DISORDERS;
POSTTRAUMATIC-STRESS; COMBAT DEPLOYMENT; MAJOR DEPRESSION; SUBSTANCE
USE; MILITARY; SOLDIERS; RESILIENCE
AB IMPORTANCE The rate of suicide attempts in the US Army increased sharply during the wars in Afghanistan and Iraq. Research on this important health outcome has been hampered by the lack of integration among Army administrative data systems.
OBJECTIVE To identify risk factors for suicide attempts among active-duty members of the regular Army from January 1, 2004, through December 31, 2009.
DESIGN, SETTING, AND PARTICIPANTS This longitudinal, retrospective cohort study, as part of the Army Study to Assess Risk and Resilience in Service members (STARRS), used individual-level person-month records from Army and Department of Defense administrative data systems to examine sociodemographic, service-related, and mental health predictors of medically documented suicide attempts among active-duty regular Army soldiers from January 1, 2004, through December 31, 2009. We analyzed data from 9791 suicide attempters and an equal-probability sample of 183 826 control person-months using a discrete-time survival framework. Data analysis was performed from February 3 through November 12, 2014.
MAIN OUTCOMES AND MEASURES Suicide attempts identified using Department of Defense Suicide Event Report records and diagnostic codes E950 through E958 from the International Classification of Diseases, Ninth Revision, Clinical Modification. Standardized estimates of suicide attempt risk for sociodemographic, service-related, and mental health predictor variables were constructed from Army personnel and medical records.
RESULTS Enlisted soldiers accounted for 98.6% of all suicide attempts (9650 attempters; overall rate, 377.0 [95% CI, 369.7-384.7] per 100 000 person-years). In multivariate models, suicide attempts among enlisted soldiers were predicted (data reported as odds ratio [95% CI]) by female sex (2.4 [2.3-2.5]), entering Army service at 25 years or older (1.6 [1.5-1.8]), current age of 29 years or younger (<21 years, 5.6 [5.1-6.2]; 21-24 years, 2.9 [2.6-3.2]; 25-29 years, 1.6 [1.5-1.8]), white race (black, 0.7 [0.6-0.7]; Hispanic, 0.7 [0.7-0.8]; Asian, 0.7 [0.6-0.8]), an educational level of less than high school (2.0 [2.0-2.1]), being in the first 4 years of service (1-2 years, 2.4 [2.2-2.6]; 3-4 years, 1.5 [1.4-1.6]), having never (2.8 [2.6-3.0]) or previously (2.6 [2.4-2.8]) been deployed, and a mental health diagnosis during the previous month (18.2 [17.4-19.1]). Attempts among officers (overall rate, 27.9 per 100 000 person-years) were predicted by female sex (2.8 [2.0-4.1]), entering Army service at 25 years or older (2.0 [1.3-3.1]), current age of 40 years or older (0.5 [0.3-0.8]), and a mental health diagnosis during the previous month (90.2 [59.5-136.7]). Discrete-time hazard models indicated risk among enlisted soldiers was highest in the second month of service (102.7 per 100000 person-months) and declined substantially as length of service increased (mean during the second year of service, 56.0 per 100000 person-years; after 4 years of service, 29.4 per 100000 person-months), whereas risk among officers remained stable (overall mean, 6.1 per 100000 person-months).
CONCLUSIONS AND RELEVANCE Our results represent, to our knowledge, the most comprehensive accounting to date of suicide attempts in the Army. The findings reveal unique risk profiles for enlisted soldiers and officers and highlight the importance of research and prevention focused on enlisted soldiers in their first Army tour.
C1 [Ursano, Robert J.; Naifeh, James A.; Aliaga, Pablo A.; Fullerton, Carol S.] Uniformed Serv Univ Hlth Sci, Dept Psychiat, Ctr Study Traumat Stress, Bethesda, MD 20814 USA.
[Kessler, Ronald C.; Sampson, Nancy A.] Harvard Univ, Sch Med, Dept Hlth Care Policy, Boston, MA 02115 USA.
[Stein, Murray B.] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA.
[Stein, Murray B.] Univ Calif San Diego, Dept Family & Prevent Med, La Jolla, CA 92093 USA.
[Stein, Murray B.] Vet Affairs San Diego Healthcare Syst, Psychiat Serv, San Diego, CA USA.
[Kao, Tzu-Cheg] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA.
[Colpe, Lisa J.; Schoenbaum, Michael] NIMH, Bethesda, MD 20892 USA.
[Cox, Kenneth L.] US Army Publ Hlth Command, Aberdeen Proving Ground, MD USA.
[Heeringa, Steven G.] Univ Michigan, Inst Social Res, Ann Arbor, MI USA.
RP Ursano, RJ (reprint author), Uniformed Serv Univ Hlth Sci, Dept Psychiat, Ctr Study Traumat Stress, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.
EM robert.ursano@usuhs.edu
RI Wessely, Simon/A-8713-2008
FU US Department of the Army; US Department of Health and Human Services,
National Institutes of Health, NIMH [U01MH087981]
FX Army STARRS was sponsored by the US Department of the Army and funded by
cooperative agreement U01MH087981 with the US Department of Health and
Human Services, National Institutes of Health, NIMH.
NR 40
TC 9
Z9 9
U1 3
U2 11
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 2168-622X
EI 2168-6238
J9 JAMA PSYCHIAT
JI JAMA Psychiatry
PD SEP
PY 2015
VL 72
IS 9
BP 917
EP 926
DI 10.1001/jamapsychiatry.2015.0987
PG 10
WC Psychiatry
SC Psychiatry
GA CR0DE
UT WOS:000360987600011
PM 26154106
ER
PT J
AU Camacho, M
Liu, SY
Certal, V
Capasso, R
Powell, NB
Riley, RW
AF Camacho, Macario
Liu, Stanley Yung
Certal, Victor
Capasso, Robson
Powell, Nelson B.
Riley, Robert W.
TI Large maxillomandibular advancements for obstructive sleep apnea: An
operative technique evolved over 30 years
SO JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
LA English
DT Article
DE Maxillomandibular advancement; Obstructive sleep apnea; Sleep surgery;
Genioglossus advancement; Operative Technique
ID METAANALYSIS; OSTEOTOMY; SURGERY
AB Objective: Obstructive sleep apnea (USA) can be a challenging disorder to treat. Maxillomandibular advancements (MMAs) generally have high success rates; however, larger advancements have higher success and cure rates. Our aim is to present and to describe the current technique used by the senior authors, which has been successful for performing large advancements, thereby improving postoperative outcomes.
Methods: The senior authors have developed and modified their maxillomandibular advancement operative techniques significantly over the past 30 years. The current version of the Riley-Powell MMA technique is described in a step-by-step fashion in this article.
Results: Initially, as part of the MMAs, patients underwent maxillomandibular fixation with wires, lag screws and harvested split calvarial bone grafts. The current technique utilizes plates, screws, Erich Arch Bars, and suspension wires which are left in place for 5-6 weeks. Guiding elastics are worn for the first week. The MMA technique described in this article has yielded a success rate over 90% for patients with a body mass index (BMI) <40 kg/m(2) and 81% for patients with a BMI >= 40 kg/m(2).
Conclusion: Large advancements during maxillomandibular advancement surgeries can help improve post-operative obstructive sleep apnea outcomes. Published by Elsevier Ltd on behalf of European Association for Cranio-Maxillo-Facial Surgery.
C1 [Camacho, Macario] Tripler Army Med Ctr, Dept Otolaryngol, Div Sleep Surg & Med, Honolulu, HI 96859 USA.
[Camacho, Macario] Stanford Hosp & Clin, Dept Psychiat & Behav Sci, Div Sleep Med, Redwood City, CA USA.
[Liu, Stanley Yung; Capasso, Robson; Powell, Nelson B.; Riley, Robert W.] Stanford Univ, Med Ctr, Dept Otolaryngol Head & Neck Surg, Sleep Surg Div, Stanford, CA 94305 USA.
[Certal, Victor] Sleep Med Ctr Hosp CUF, Dept Otorhinolaryngol, Oporto, Portugal.
[Certal, Victor] Univ Porto, CINTESIS Ctr Res Hlth Technol & Informat Syst, P-4100 Oporto, Portugal.
RP Camacho, M (reprint author), Tripler Army Med Ctr, Dept Otolaryngol, Div Sleep Surg & Med, 1 Jarrett White Rd, Honolulu, HI 96859 USA.
EM drcamachoent@yahoo.com
RI FMUP, CINTESIS/C-6631-2014;
OI FMUP, CINTESIS/0000-0001-7248-2086; Certal, Victor/0000-0002-1904-9504;
Camacho, Macario/0000-0001-9200-9085
NR 18
TC 5
Z9 5
U1 0
U2 5
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 1010-5182
EI 1878-4119
J9 J CRANIO MAXILL SURG
JI J. Cranio-MaxilloFac. Surg.
PD SEP
PY 2015
VL 43
IS 7
BP 1113
EP 1118
DI 10.1016/j.jcms.2015.05.015
PG 6
WC Dentistry, Oral Surgery & Medicine; Surgery
SC Dentistry, Oral Surgery & Medicine; Surgery
GA CR1IP
UT WOS:000361078700023
PM 26116307
ER
PT J
AU Borke, JL
McAllister, B
Harris, T
Neiberg, M
Guevarra-Toth, C
Fulzele, S
Stoianovici, C
Guerra, C
AF Borke, James L.
McAllister, Bennett
Harris, Tiffenie
Neiberg, Maryke
Guevarra-Toth, Chestine
Fulzele, Sadanand
Stoianovici, Charles
Guerra, Carlos
TI Correlation of changes in the mandible and retina/choroid vasculature of
a rat model of BRONJ
SO JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
LA English
DT Article
DE Bisphosphonate; MRONJ; BRONJ; Choroid/retina
ID NITROGEN-CONTAINING BISPHOSPHONATES; ANGIOGENESIS IN-VITRO; ZOLEDRONIC
ACID; ENDOTHELIAL-CELLS; SIGNALING PATHWAYS; OSTEONECROSIS; BONE; JAWS;
THERAPY; VIVO
AB Bisphosphonate-related osteonecrosis of the jaw (BRONJ) causes bones of the mandible and maxilla to become necrotic and protrude into the oral cavity. Compromised blood supply to bone is also a feature of BRONJ. The design of this study was first to use our established technique of molar extraction and IV bisphosphonate injection to produce features of BRONJ in rats that mimic the human disease; second to confirm vascular changes in the mandible and eye using micro-CT of vascular casts, and image analysis of retina/choroid images; and third to show parallel bisphosphonate-induced changes in the structure and markers of the vasculature of the bone and eye. The results of this study show structural changes in the eye and mandible as well as biochemical changes including the up-regulation of VEGF in response to the bisphosphonate-associated ischemia. These changes are not associated with angiogenesis in either the eye or mandible as determined by reduced vascular complexity. These results suggest that observations of direct changes to the vasculature in the retina/choroid structures of the eye in patients taking bisphosphonates could serve as a window to the progression of debilitating changes occurring as a result of bisphosphonate therapy. (C) 2015 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.
C1 [Borke, James L.; Stoianovici, Charles; Guerra, Carlos] Western Univ Hlth Sci, Coll Dent Med, Pomona, CA 91766 USA.
[McAllister, Bennett; Harris, Tiffenie; Neiberg, Maryke] Western Univ Hlth Sci, Coll Optometry, Pomona, CA 91766 USA.
[Guevarra-Toth, Chestine] US Army, Adv Educ Program Periodont, Ft Gordon, GA 30905 USA.
[Fulzele, Sadanand] Georgia Regents Univ, Dept Orthoped Surg, Augusta, GA 30912 USA.
RP Borke, JL (reprint author), Western Univ Hlth Sci, Coll Dent Med, 309 E Second St, Pomona, CA 91766 USA.
EM jborke@westernu.edu
FU AO Foundation, Davos, Switzerland; The United States Army Advanced
Education Program in Periodontics, Fort Gordon, GA; Western University
of Health Sciences College of Dental Medicine, Pomona, CA
FX This work was supported by the AO Foundation, Davos, Switzerland (JLB);
The United States Army Advanced Education Program in Periodontics, Fort
Gordon, GA (CSG & JLB); and the Western University of Health Sciences
College of Dental Medicine, Pomona, CA (JLB, CS, CG).
NR 29
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U1 0
U2 3
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 1010-5182
EI 1878-4119
J9 J CRANIO MAXILL SURG
JI J. Cranio-MaxilloFac. Surg.
PD SEP
PY 2015
VL 43
IS 7
BP 1144
EP 1150
DI 10.1016/j.jcms.2015.05.021
PG 7
WC Dentistry, Oral Surgery & Medicine; Surgery
SC Dentistry, Oral Surgery & Medicine; Surgery
GA CR1IP
UT WOS:000361078700028
PM 26154398
ER
PT J
AU Shelhamer, MC
Rowan, MP
Cancio, LC
Aden, JK
Rhie, RY
Merrill, GA
Wolf, SE
Renz, EM
Chung, KK
AF Shelhamer, Mehdi C.
Rowan, Matthew P.
Cancio, Leopoldo C.
Aden, James K.
Rhie, Ryan Y.
Merrill, Gerald A.
Wolf, Steven E.
Renz, Evan M.
Chung, Kevin K.
TI Recent trends in hospitalization and in-hospital mortality associated
with traumatic brain injury in Canada: A nationwide, population-based
study
SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
LA English
DT Article
ID RESPIRATORY-DISTRESS-SYNDROME; FREQUENCY PERCUSSIVE VENTILATION;
INHALATION INJURY; PREDICTIVE-VALUE; TIDAL VOLUMES; BURN PATIENT;
PNEUMONIA; TIME; STRATEGIES; BIOMARKERS
C1 [Shelhamer, Mehdi C.] Univ Cincinnati, Med Ctr, US Air Force, Ctr Sustainment Trauma & Readiness Skills, Cincinnati, OH 45267 USA.
[Rowan, Matthew P.; Cancio, Leopoldo C.; Aden, James K.; Rhie, Ryan Y.; Merrill, Gerald A.; Renz, Evan M.; Chung, Kevin K.] US Army, Inst Surg Res, Jbsa Ft Sam Houston, TX USA.
[Cancio, Leopoldo C.; Chung, Kevin K.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA.
[Wolf, Steven E.] Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USA.
[Renz, Evan M.; Chung, Kevin K.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
RP Rowan, MP (reprint author), 3698 Chambers Pass, San Antonio, TX 78234 USA.
EM matthew.p.rowan.vol@mail.mil
FU Percussionaire, Inc.
FX This research was supported in part by an appointment (M.P.R.) to the
Postgraduate Research Participation Program and an appointment (L.C.C.)
to the Knowledge Preservation Program at the US Army Institute of
Surgical Research administered by the Oak Ridge Institute for Science
and Education through an interagency agreement between the US Department
of Energy and USAMRMC. L.C.C. received funding for travel expenses from
Percussionaire, Inc., to speak at the Bird Institute, Sandpoint, Idaho,
in 2013. The authors have no other conflicts of interest to declare.
NR 36
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Z9 1
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 2163-0755
EI 2163-0763
J9 J TRAUMA ACUTE CARE
JI J. Trauma Acute Care Surg.
PD SEP
PY 2015
VL 79
IS 3
BP 431
EP 436
PG 6
WC Critical Care Medicine; Surgery
SC General & Internal Medicine; Surgery
GA CQ4JV
UT WOS:000360571900018
PM 26307877
ER
PT J
AU Lovering, ME
Heaton, KJ
Banderet, LE
Neises, K
Andrews, J
Cohen, BS
AF Lovering, Meghan E.
Heaton, Kristin J.
Banderet, Louis E.
Neises, Kameran
Andrews, James
Cohen, Bruce S.
TI Psychological and Physical Characteristics of US Marine Recruits
SO MILITARY PSYCHOLOGY
LA English
DT Article
DE Marines; training; psychological factors; physical factors
ID SENSATION SEEKING; MILITARY RECRUITS; NAVY ATTRITION; PREDICTORS;
HARDINESS; ARMY; GRIT; RELIABILITY; INJURIES; VALIDITY
AB This study examined psychological and physical health factors in a cohort of U.S. Marine recruits with the goal of developing a comprehensive understanding of attributes recruits bring to training. 1,350 male recruits completed a multimeasure survey during the first week of training. A 2-way multivariate analysis of variance (MANOVA) was conducted to explore the relationship of hardiness dimensions on several psychological and physical factors. Compared with other military samples, this cohort reported similar levels on hardiness control and rigidity subscales. Recruits who reported higher scores on a measure of positive hardiness also reported higher scores on measures of grit, grit ambition, sensation seeking, training expectations, positive ways of coping, physical and mental health, fitness scores, and lower scores on a measure of depression. This study provides a more complete understanding of the complex array of attributes of Marine recruits and forms a foundation for predictive models of injury risk and/or attrition.
C1 [Lovering, Meghan E.; Heaton, Kristin J.; Banderet, Louis E.; Cohen, Bruce S.] US Army Res Inst Environm Med, Mil Performance Div, Natick, MA 01760 USA.
[Heaton, Kristin J.] Boston Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02215 USA.
[Neises, Kameran; Andrews, James] Naval Hlth Res Ctr, Warfighter Performance, San Diego, CA USA.
RP Lovering, ME (reprint author), US Army Res Inst Environm Med, Mil Performance Div, 15 Kansas St,Bldg 42, Natick, MA 01760 USA.
EM meghan.e.lovering.ctr@mail.mil
FU Postgraduate Research Participation Program at the U.S. Army Research
Institute of Environmental Medicine
FX The opinions or assertions contained herein are the private views of the
author(s) and are not to be construed as official or as reflecting the
views of the Army or the Department of Defense. This research was
supported in part by an appointment to the Postgraduate Research
Participation Program at the U.S. Army Research Institute of
Environmental Medicine administered by the Oak Ridge Institute for
Science and Education through an interagency agreement between the U.S.
Department of Energy and U.S. Army Medical Research Materiel Command
(USAMRMC). The authors would like to acknowledge Dr. Stephanie
Booth-Kewley, James Reading, and Christian Hansen, Commanding Officer of
MCRD San Diego for lending their expertise with this paper.
NR 45
TC 1
Z9 1
U1 7
U2 20
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0899-5605
EI 1532-7876
J9 MIL PSYCHOL
JI Milit. Psychol.
PD SEP
PY 2015
VL 27
IS 5
BP 261
EP 275
DI 10.1037/mil0000082
PG 15
WC Psychology, Multidisciplinary
SC Psychology
GA CR1DL
UT WOS:000361063300001
ER
PT J
AU Rizzo, JA
Johnson, R
Cartie, RJ
AF Rizzo, Julie A.
Johnson, Rebekah
Cartie, Richard J.
TI Pediatric Toxic Epidermal Necrolysis: Experience of a Tertiary Burn
Center
SO PEDIATRIC DERMATOLOGY
LA English
DT Article
ID STEVENS-JOHNSON-SYNDROME; OF-THE-LITERATURE; INTRAVENOUS IMMUNOGLOBULIN;
CHILDREN
AB BackgroundPediatric toxic epidermal necrolysis (TEN) is a rare and potentially fatal skin disease with a multitude of causative factors and no consensus on treatment guidelines and, as a result, it has a variety of short- and long-term outcomes. We present the experience of a large specialty burn center to share our diagnostic and treatment principles.
MethodsA retrospective review from 1989 to 2010 at the Joseph M. Still Burn Center was performed to find patients with a diagnosis of Steven-Johnson syndrome (SJS) or TEN. Information was obtained on demographic and physiologic parameters such as age, race, total body surface area involved, treatments, hospital stay, and need for ventilator support.
ResultsWe identified SJS or TEN in 21 patients. Prescription drugs were the most common etiology (in 15 patients), with antibiotics as the most common causative agent. Histology confirmed the clinical diagnosis of TEN in 14 patients. Our treatment plan included a multidisciplinary team, early initiation of intravenous immunoglobulin, bronchoscopy, strict management of electrolyte and fluid balances, and meticulous surgical wound care. Mortality was 9.5%.
ConclusionOur experience in treating this rare but devastating disease affords us the opportunity to share the diagnostic dilemmas we faced and the treatment principles we used to treat this unique patient population successfully.
C1 [Rizzo, Julie A.] US Army, Inst Surg Res, Ft Sam Houston, TX USA.
[Johnson, Rebekah] Dwight D Eisenhower Army Med Ctr, Dept Surg, Ft Gordon, GA USA.
[Cartie, Richard J.] Joseph M Still Burn Ctr, Pediat Intens Care Serv, Augusta, GA USA.
RP Rizzo, JA (reprint author), US Army Inst Surg Res, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA.
EM julie.a.rizzo.mil@mail.mil
NR 18
TC 0
Z9 0
U1 3
U2 5
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0736-8046
EI 1525-1470
J9 PEDIATR DERMATOL
JI Pediatr. Dermatol.
PD SEP-OCT
PY 2015
VL 32
IS 5
BP 704
EP 709
DI 10.1111/pde.12657
PG 6
WC Dermatology; Pediatrics
SC Dermatology; Pediatrics
GA CR2TR
UT WOS:000361184000034
PM 26227567
ER
PT J
AU Ma, L
He, T
Swami, A
Towsley, D
Leung, KK
AF Ma, Liang
He, Ting
Swami, Ananthram
Towsley, Don
Leung, Kin K.
TI On optimal monitor placement for localizing node failures via network
tomography
SO PERFORMANCE EVALUATION
LA English
DT Article; Proceedings Paper
CT 33rd International Symposium on Computer Performance, Modeling,
Measurements, and Evaluation / IFIP WG 7.3 Performance
CY OCT 19-21, 2015
CL Sydney, AUSTRALIA
DE Network tomography; Failure localization; Maximum node identifiability;
Optimal monitor placement algorithm
AB We investigate the problem of placing monitors to localize node failures in a communication network from binary states (normal/failed) of end-to-end paths, under the assumption that a path is in normal state if and only if it contains no failed nodes. To uniquely localize failed nodes, the measurement paths must show different symptoms (path states) under different failure events. Our goal is to deploy the minimum set of monitors to satisfy this condition for a given probing mechanism. We consider three families of probing mechanisms, according to whether measurement paths are (i) arbitrarily controllable, (ii) controllable but cycle-free, or (iii) uncontrollable (i.e., determined by the default routing protocol). We first establish theoretical conditions that characterize network-wide failure identifiability through a per-node identifiability measure that can be efficiently evaluated for the above three probing mechanisms. Leveraging these results, we develop a generic monitor placement algorithm, applicable under any probing mechanism, that incrementally selects monitors to optimize the per-node measure. The proposed algorithm is shown to be optimal for probing mechanism (i), and provides upper and lower bounds on the minimum number of monitors required by the other probing mechanisms. In the special case of single-node failures, we develop an improved monitor placement algorithm that is optimal for probing mechanism (ii) and has linear time complexity. Using these algorithms, we study the impact of the probing mechanism on the number of monitors required for uniquely localizing node failures. Our results based on real network topologies show that although more complicated to implement, probing mechanisms that allow monitors to control measurement paths substantially reduce the required number of monitors. (C) 2015 Elsevier B.V. All rights reserved.
C1 [Ma, Liang] IBM TJ Watson Res Ctr, Cloud Based Networking Dept, Yorktown Hts, NY 10598 USA.
[He, Ting] IBM TJ Watson Res Ctr, Network Analyt Res Grp, Yorktown Hts, NY USA.
[Swami, Ananthram] Army Res Lab, Network Sci, Adelphi, MD USA.
[Towsley, Don] Univ Massachusetts, Dept Comp Sci, Amherst, MA 01003 USA.
[Leung, Kin K.] Univ London Imperial Coll Sci Technol & Med, Elect & Elect Engn EEE Dept, London, England.
[Leung, Kin K.] Univ London Imperial Coll Sci Technol & Med, Dept Comp, London, England.
RP Ma, L (reprint author), IBM TJ Watson Res Ctr, Cloud Based Networking Dept, Yorktown Hts, NY 10598 USA.
EM maliang@us.ibm.com; the@us.ibm.com; ananthram.swami.civ@mail.mil;
towsley@cs.umass.edu; kin.leung@imperial.ac.uk
FU US Army Research Laboratory; UK Ministry of Defence [W911NF-06-3-0001]
FX Research was sponsored by the US Army Research Laboratory and the UK
Ministry of Defence and was accomplished under Agreement Number
W911NF-06-3-0001. The views and conclusions contained in this document
are those of the authors and should not be interpreted as representing
the official policies, either expressed or implied, of the US Army
Research Laboratory, the US Government, the UK Ministry of Defence or
the UK Government. The US and UK Governments are authorized to reproduce
and distribute reprints for Government purposes notwithstanding any
copyright notation hereon.
NR 27
TC 1
Z9 1
U1 1
U2 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0166-5316
EI 1872-745X
J9 PERFORM EVALUATION
JI Perform. Eval.
PD SEP
PY 2015
VL 91
SI SI
BP 16
EP 37
DI 10.1016/j.peva.2015.06.003
PG 22
WC Computer Science, Hardware & Architecture; Computer Science, Theory &
Methods
SC Computer Science
GA CQ8PW
UT WOS:000360871900003
ER
PT J
AU Urgaonkar, R
Wang, SQ
He, T
Zafer, M
Chan, K
Leung, KK
AF Urgaonkar, Rahul
Wang, Shiqiang
He, Ting
Zafer, Murtaza
Chan, Kevin
Leung, Kin K.
TI Dynamic service migration and workload scheduling in edge-clouds
SO PERFORMANCE EVALUATION
LA English
DT Article; Proceedings Paper
CT 33rd International Symposium on Computer Performance, Modeling,
Measurements, and Evaluation / IFIP WG 7.3 Performance
CY OCT 19-21, 2015
CL Sydney, AUSTRALIA
DE Edge-clouds; Service migration; Stochastic optimization; Markov decision
processes
ID NETWORKS
AB Edge-clouds provide a promising new approach to significantly reduce network operational costs by moving computation closer to the edge. A key challenge in such systems is to decide where and when services should be migrated in response to user mobility and demand variation. The objective is to optimize operational costs while providing rigorous performance guarantees. In this paper, we model this as a sequential decision making Markov Decision Problem (MDP). However, departing from traditional solution methods (such as dynamic programming) that require extensive statistical knowledge and are computationally prohibitive, we develop a novel alternate methodology. First, we establish an interesting decoupling property of the MDP that reduces it to two independent MDPs on disjoint state spaces. Then, using the technique of Lyapunov optimization over renewals, we design an online control algorithm for the decoupled problem that is provably cost-optimal. This algorithm does not require any statistical knowledge of the system parameters and can be implemented efficiently. We validate the performance of our algorithm using extensive trace-driven simulations. Our overall approach is general and can be applied to other MDPs that possess a similar decoupling property. (C) 2015 Elsevier B.V. All rights reserved.
C1 [Urgaonkar, Rahul] IBM TJ Watson Res Ctr, Cloud Based Networks Grp, Yorktown Hts, NY 10598 USA.
[He, Ting] IBM TJ Watson Res Ctr, Network Analyt Res Grp, Yorktown Hts, NY USA.
[Wang, Shiqiang; Leung, Kin K.] Univ London Imperial Coll Sci Technol & Med, Dept Elect & Elect Engn, London SW7 2AZ, England.
[Zafer, Murtaza] Nyansa Inc, Analyt Portfolio Co, Palo Alto, CA USA.
[Chan, Kevin] US Army Res Lab, Computat & Informat Sci Directorate, Adelphi, MD USA.
RP Urgaonkar, R (reprint author), IBM TJ Watson Res Ctr, Cloud Based Networks Grp, Yorktown Hts, NY 10598 USA.
EM rurgaon@us.ibm.com; shiqiang.wang11@imperial.ac.uk; the@us.ibm.com;
murtaza.zafer.us@ieee.org; kevin.s.chan.civ@mail.mil;
kin.leung@imperial.ac.uk
FU US Army Research Laboratory; UK Ministry of Defence [W911NF-06-3-0001]
FX This research was sponsored in part by the US Army Research Laboratory
and the UK Ministry of Defence and was accomplished under Agreement
Number W911NF-06-3-0001. The views and conclusions contained in this
document are those of the author(s) and should not be interpreted as
representing the official policies, either expressed or implied, of the
US Army Research Laboratory, the US Government, the UK Ministry of
Defence or the UK Government. The US and UK Governments are authorized
to reproduce and distribute reprints for Government purposes
notwithstanding any copyright notation hereon.
NR 22
TC 9
Z9 9
U1 0
U2 6
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0166-5316
EI 1872-745X
J9 PERFORM EVALUATION
JI Perform. Eval.
PD SEP
PY 2015
VL 91
SI SI
BP 205
EP 228
DI 10.1016/j.peva.2015.06.013
PG 24
WC Computer Science, Hardware & Architecture; Computer Science, Theory &
Methods
SC Computer Science
GA CQ8PW
UT WOS:000360871900013
ER
PT J
AU Rong, CC
AF Rong, Charles C.
TI A better approach to assess quality and performance of coated conductors
SO SUPERCONDUCTOR SCIENCE & TECHNOLOGY
LA English
DT Editorial Material
C1 US Army Res Lab, Adelphi, MD 20783 USA.
RP Rong, CC (reprint author), US Army Res Lab, Adelphi, MD 20783 USA.
EM Charles.c.rong.civ@mail.mil
NR 10
TC 0
Z9 0
U1 1
U2 4
PU IOP PUBLISHING LTD
PI BRISTOL
PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
SN 0953-2048
EI 1361-6668
J9 SUPERCOND SCI TECH
JI Supercond. Sci. Technol.
PD SEP
PY 2015
VL 28
IS 9
AR 090503
DI 10.1088/0953-2048/28/9/090503
PG 2
WC Physics, Applied; Physics, Condensed Matter
SC Physics
GA CQ9NU
UT WOS:000360942700003
ER
PT J
AU Burmeister, DM
Becerra, SC
Wrice, NL
Natesan, S
Christy, RJ
AF Burmeister, D. M.
Becerra, S. C.
Wrice, N. L.
Natesan, S.
Christy, R. J.
TI PEGylated Fibrin Hydrogels for Delivery of Adipose Stem Cells to
Deep-Partial Thickness Burn Wounds
SO TISSUE ENGINEERING PART A
LA English
DT Meeting Abstract
CT 4th TERMIS World Congress
CY SEP 08-11, 2015
CL Boston, MA
SP TERMIS
C1 [Burmeister, D. M.; Becerra, S. C.; Wrice, N. L.; Natesan, S.; Christy, R. J.] US Army Inst Surg Res, ETRM, Ft Sam Houston, TX USA.
NR 0
TC 0
Z9 0
U1 2
U2 2
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1937-3341
EI 1937-335X
J9 TISSUE ENG PT A
JI Tissue Eng. Part A
PD SEP 1
PY 2015
VL 21
SU 1
BP S133
EP S133
PG 1
WC Cell & Tissue Engineering; Biotechnology & Applied Microbiology; Cell
Biology
SC Cell Biology; Biotechnology & Applied Microbiology
GA CP9HR
UT WOS:000360205201123
ER
PT J
AU Kaini, RR
Cleland, JM
Wang, H
AF Kaini, R. R.
Cleland, J. M.
Wang, H.
TI Extracellular Matrix Remodeling During Retina Development In Vitro
SO TISSUE ENGINEERING PART A
LA English
DT Meeting Abstract
CT 4th TERMIS World Congress
CY SEP 08-11, 2015
CL Boston, MA
SP TERMIS
C1 [Kaini, R. R.; Cleland, J. M.; Wang, H.] US Army, Inst Surg Res, Ocular Trauma, Ft Sam Houston, TX 78234 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1937-3341
EI 1937-335X
J9 TISSUE ENG PT A
JI Tissue Eng. Part A
PD SEP 1
PY 2015
VL 21
SU 1
BP S182
EP S182
PG 1
WC Cell & Tissue Engineering; Biotechnology & Applied Microbiology; Cell
Biology
SC Cell Biology; Biotechnology & Applied Microbiology
GA CP9HR
UT WOS:000360205201310
ER
PT J
AU Natesan, S
Baker, BA
Wrice, NL
Coronado, RE
Christy, RJ
AF Natesan, S.
Baker, B. A.
Wrice, N. L.
Coronado, R. E.
Christy, R. J.
TI A Human Plasma-Extracellular Matrix Composite for Improved Skin
Regeneration
SO TISSUE ENGINEERING PART A
LA English
DT Meeting Abstract
CT 4th TERMIS World Congress
CY SEP 08-11, 2015
CL Boston, MA
SP TERMIS
C1 [Natesan, S.; Baker, B. A.; Wrice, N. L.; Coronado, R. E.; Christy, R. J.] US Army Inst Surg Res, Extrem Trauma & Regenerat Med, San Antonio, TX USA.
NR 0
TC 0
Z9 0
U1 2
U2 2
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1937-3341
EI 1937-335X
J9 TISSUE ENG PT A
JI Tissue Eng. Part A
PD SEP 1
PY 2015
VL 21
SU 1
BP S123
EP S123
PG 1
WC Cell & Tissue Engineering; Biotechnology & Applied Microbiology; Cell
Biology
SC Cell Biology; Biotechnology & Applied Microbiology
GA CP9HR
UT WOS:000360205201083
ER
PT J
AU Kellermann, AL
Mabry, R
AF Kellermann, Arthur L.
Mabry, Robert
TI Bringing a Battlefield Lesson Home
SO ACADEMIC EMERGENCY MEDICINE
LA English
DT Editorial Material
ID HOSPITAL CARDIAC-ARREST; COMBAT CASUALTY CARE; SURVIVAL; TRAUMA;
DEFIBRILLATION; COMMITTEE; SYSTEM
C1 [Kellermann, Arthur L.] Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Bethesda, MD 20814 USA.
[Mabry, Robert] US Army Inst Surg Res, Joint Base San Antonio, Ft Sam Houston, TX USA.
RP Kellermann, AL (reprint author), Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Bethesda, MD 20814 USA.
EM Akellermann@usuhs.edu
NR 16
TC 1
Z9 1
U1 0
U2 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1069-6563
EI 1553-2712
J9 ACAD EMERG MED
JI Acad. Emerg. Med.
PD SEP
PY 2015
VL 22
IS 9
BP 1093
EP 1095
DI 10.1111/acem.12749
PG 3
WC Emergency Medicine
SC Emergency Medicine
GA CQ8CO
UT WOS:000360834000011
PM 26291434
ER
PT J
AU Legler, PM
Soojhawon, I
Millard, CB
AF Legler, Patricia M.
Soojhawon, Iswarduth
Millard, Charles B.
TI A conformational change in the peripheral anionic site of Torpedo
californica acetylcholinesterase induced by a bis-imidazolium oxime
SO ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY
LA English
DT Article
DE acetylcholinesterase; peripheral anionic site; allosterism; oxime;
organophosphate
ID BLOOD-BRAIN-BARRIER; ORGANOPHOSPHORUS COMPOUNDS; PYRIDINIUM OXIMES;
NERVE AGENTS; INHIBITED ACETYLCHOLINESTERASE; REACTIVATION KINETICS;
CRYSTAL-STRUCTURES; WHOLE-BLOOD; CHOLINESTERASE; EFFICACY
AB As part of ongoing efforts to design improved nerve agent antidotes, two X-ray crystal structures of Torpedo californica acetylcholinesterase (TcAChE) bound to the bis-pyridinium oxime, Ortho-7, or its experimental bis-imidazolium analogue, 2BIM-7, were determined. Bis-oximes contain two oxime groups connected by a hydrophobic linker. One oxime group of Ortho-7 binds at the entrance to the active-site gorge near Trp279, and the second binds at the bottom near Trp84 and Phe330. In the Ortho-7-TcAChE complex the oxime at the bottom of the gorge was directed towards the nucleophilic Ser200. In contrast, the oxime group of 2BIM-7 was rotated away from Ser200 and the oxime at the entrance induced a significant conformational change in the peripheral anionic site (PAS) residue Trp279. The conformational change alters the surface of the PAS and positions the imidazolium oxime of 2BIM-7 further from Ser200. The relatively weaker binding and poorer reactivation of VXinhibited, tabun-inhibited or sarin-inhibited human acetylcholinesterase by 2BIM-7 compared with Ortho-7 may in part be owing to the unproductively bound states caught in crystallo. Overall, the reactivation efficiency of 2BIM-7 was comparable to that of 2-pyridine aldoxime methyl chloride (2-PAM), but unlike 2-PAM the bis-imidazolium oxime lacks a fixed charge, which may affect its membrane permeability.
C1 [Legler, Patricia M.] US Naval Res Lab, CBMSE, Washington, DC 20375 USA.
[Soojhawon, Iswarduth] Walter Reed Army Inst Res, Bacterial Dis, Silver Spring, MD 20910 USA.
[Millard, Charles B.] Walter Reed Army Inst Res, Div Biochem, Silver Spring, MD 20910 USA.
RP Legler, PM (reprint author), US Naval Res Lab, CBMSE, 4555 Overlook Ave, Washington, DC 20375 USA.
EM patricia.legler@nrl.navy.mil
FU US Defense Threat Reduction Agency JSTO [E0036_08_WR_C]; Office of Naval
Research/Naval Research Laboratory 6.1 base
FX This work was funded by the US Defense Threat Reduction Agency JSTO
award E0036_08_WR_C to (CBM) and the Office of Naval Research/Naval
Research Laboratory 6.1 base funding. The opinions or assertions
contained herein belong to the authors and are not necessarily the
official views of the US Army, the US Navy or the US Department of
Defense.
NR 72
TC 0
Z9 0
U1 0
U2 6
PU INT UNION CRYSTALLOGRAPHY
PI CHESTER
PA 2 ABBEY SQ, CHESTER, CH1 2HU, ENGLAND
SN 2059-7983
J9 ACTA CRYSTALLOGR D
JI Acta Crystallogr. Sect. D-Struct. Biol.
PD SEP
PY 2015
VL 71
BP 1788
EP 1798
DI 10.1107/S1399004715011281
PN 9
PG 11
WC Biochemical Research Methods; Biochemistry & Molecular Biology;
Biophysics; Crystallography
SC Biochemistry & Molecular Biology; Biophysics; Crystallography
GA CQ5OH
UT WOS:000360654300001
PM 26327369
ER
PT J
AU Switaj, TL
Winter, KJ
Christensen, SR
AF Switaj, Timothy L.
Winter, Kelly J.
Christensen, Scott R.
TI Diagnosis and Management of Foodborne Illness
SO AMERICAN FAMILY PHYSICIAN
LA English
DT Article
ID HEMOLYTIC-UREMIC SYNDROME; ORAL REHYDRATION THERAPY; ACUTE
GASTROENTERITIS; ACUTE DIARRHEA; UNITED-STATES; BISMUTH SUBSALICYLATE;
INFECTIOUS DIARRHEA; CHILDREN; GUIDELINES; TRAVELERS
AB The Centers for Disease Control and Prevention estimates that each year, one in six Americans will experience a foodborne illness. The most common causes in the United States are viruses, such as norovirus; bacteria, such as Salmonella, Escherichia coli, Campylobacter, and Listeria; and parasites, such as Toxoplasma gondii and Giardia. Resources are available to educate consumers on food recalls and proper handling, storage, and cooking of foods. Diagnosis and management of a foodborne illness are based on the history and physical examination. Common symptoms of foodborne illnesses include vomiting, diarrhea (with or without blood), fever, abdominal cramping, headache, dehydration, myalgia, and arthralgias. Definitive diagnosis can be made only through stool culture or more advanced laboratory testing. However, these results should not delay empiric treatment if a foodborne illness is suspected. Empiric treatment should focus on symptom management, rehydration if the patient is clinically dehydrated, and antibiotic therapy. Foodborne illnesses should be reported to local and state health agencies; reporting requirements vary among states. Copyright (C) 2015 American Academy of Family Physicians.
C1 [Switaj, Timothy L.] Reynolds Army Community Hosp, Clin Serv, Oklahoma City, OK 73503 USA.
[Winter, Kelly J.] William Beaumont Army Med Ctr, Ft Bliss, TX USA.
[Christensen, Scott R.] Reynolds Army Community Hosp, Family Med clin, Oklahoma City, OK USA.
RP Switaj, TL (reprint author), Reynolds Army Community Hosp, Clin Serv, Oklahoma City, OK 73503 USA.
EM mil@mail.mil
NR 24
TC 0
Z9 0
U1 0
U2 13
PU AMER ACAD FAMILY PHYSICIANS
PI KANSAS CITY
PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA
SN 0002-838X
EI 1532-0650
J9 AM FAM PHYSICIAN
JI Am. Fam. Physician
PD SEP 1
PY 2015
VL 92
IS 5
BP 358
EP 365
PG 8
WC Primary Health Care; Medicine, General & Internal
SC General & Internal Medicine
GA CQ7KM
UT WOS:000360783000007
PM 26371569
ER
PT J
AU Costanzo, MC
Creegan, M
Lal, KG
Eller, MA
AF Costanzo, Margaret C.
Creegan, Matthew
Lal, Kerri G.
Eller, Michael A.
TI OMIP-027: Functional analysis of human natural killer cells
SO CYTOMETRY PART A
LA English
DT Article
DE NK cells; function; ICS; lymphocyte; HIV
ID NK-CELLS; MATURATION
C1 [Costanzo, Margaret C.; Creegan, Matthew; Lal, Kerri G.; Eller, Michael A.] US Mil HIV Res Program, Walter Reed Army Inst Res, Div Retrovirol, Silver Spring, MD 20910 USA.
[Costanzo, Margaret C.; Creegan, Matthew; Lal, Kerri G.; Eller, Michael A.] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA.
RP Eller, MA (reprint author), US Mil HIV Res Program MHRP HJF, Walter Reed Army Inst Res, 503 Robert Grant Ave,1N11, Silver Spring, MD 20910 USA.
EM meller@hivresearch.org
FU Henry M. Jackson Foundation for the Advancement of Military Medicine,
Inc.; U.S. Department of Defense (DOD) [W81XWH-07-2-0067]
FX Grant sponsors: Henry M. Jackson Foundation for the Advancement of
Military Medicine, Inc.; U.S. Department of Defense (DOD), Grant number:
W81XWH-07-2-0067
NR 11
TC 1
Z9 1
U1 0
U2 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1552-4922
EI 1552-4930
J9 CYTOM PART A
JI Cytom. Part A
PD SEP
PY 2015
VL 87A
IS 9
BP 803
EP 805
DI 10.1002/cyto.a.22719
PG 3
WC Biochemical Research Methods; Cell Biology
SC Biochemistry & Molecular Biology; Cell Biology
GA CQ4QU
UT WOS:000360590500007
PM 26189970
ER
PT J
AU Ananthasubramaniam, B
McCauley, E
Gust, KA
Kennedy, AJ
Muller, EB
Perkins, EJ
Nisbet, RM
AF Ananthasubramaniam, Bharath
McCauley, Edward
Gust, Kurt A.
Kennedy, Alan J.
Muller, Erik B.
Perkins, Edward J.
Nisbet, Roger M.
TI Relating suborganismal processes to ecotoxicological and population
level endpoints using a bioenergetic model
SO ECOLOGICAL APPLICATIONS
LA English
DT Article
DE bioenergetics; Daphnia magna; dynamic energy budget model; individual
growth and reproduction; molt dynamics; population growth rate; risk
assessment; sensitivity analysis; standardized toxicity tests;
toxicogenomics
ID ENERGY BUDGET MODEL; CLADOCERAN DAPHNIA-MAGNA; ENDOCRINE DISRUPTING
COMPOUNDS; GENE-EXPRESSION; PHYSIOLOGICAL ECOLOGY; ENVIRONMENTAL-STRESS;
OXYGEN-CONSUMPTION; CADMIUM EXPOSURES; RISK-ASSESSMENT; DEB THEORY
AB Ecological effects of environmental stressors are commonly evaluated using organismal or suborganismal data, such as standardized toxicity tests that characterize responses of individuals (e.g., mortality and reproduction) and a rapidly growing body of "omics" data. A key challenge for environmental risk assessment is relating such information to population dynamics. One approach uses dynamic energy budget (DEB) models that relate growth and reproduction of individuals to underlying flows of energy and elemental matter. We hypothesize that suborganismal information identifies DEB parameters that are most likely impacted by a particular stressor and that the DEB model can then project suborganismal effects on life history and population endpoints. We formulate and parameterize a model of growth and reproduction for the water flea Daphnia magna. Our model resembles previous generic bioenergetic models, but has explicit representation of discrete molts, an important feature of Daphnia life history. We test its ability to predict six endpoints commonly used in chronic toxicity studies in specified food environments. With just one adjustable parameter, the model successfully predicts growth and reproduction of individuals from a wide array of experiments performed in multiple laboratories using different clones of D. magna raised on different food sources. Fecundity is the most sensitive endpoint, and there is broad correlation between the sensitivities of fecundity and long-run growth rate, as is desirable for the default metric used in chronic toxicity tests. Under some assumptions, we can combine our DEB model with the Euler-Lotka equation to estimate longrun population growth rates at different food levels. A review of Daphnia gene-expression experiments on the effects of contaminant exposure reveals several connections to model parameters, in particular a general trend of increased transcript expression of genes involved in energy assimilation and utilization at concentrations affecting growth and reproduction. The sensitivity of fecundity to many model parameters was consistent with frequent generalized observations of decreased expression of genes involved in reproductive physiology, but interpretation of these observations requires further mechanistic modeling. We thus propose an approach based on generic DEB models incorporating few essential species-specific features for rapid extrapolation of ecotoxicogenomic assays for Daphnia-based population risk assessment.
C1 [Ananthasubramaniam, Bharath] Charite & Humboldt Univ, Inst Theoret Biol, D-10115 Berlin, Germany.
[Ananthasubramaniam, Bharath; McCauley, Edward; Nisbet, Roger M.] Univ Calif Santa Barbara, Dept Ecol Evolut & Marine Biol, Santa Barbara, CA 93106 USA.
[McCauley, Edward] Univ Calgary, Dept Biol Sci, Calgary, AB T2N 1N4, Canada.
[Gust, Kurt A.; Kennedy, Alan J.; Perkins, Edward J.] US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA.
[Muller, Erik B.; Nisbet, Roger M.] Univ Calif Santa Barbara, Inst Marine Sci, Santa Barbara, CA 93106 USA.
RP Ananthasubramaniam, B (reprint author), Charite & Humboldt Univ, Inst Theoret Biol, D-10115 Berlin, Germany.
EM bharath.ananthasubramaniam@biologie.hu-berlin.de
RI Nisbet, Roger/B-6951-2014
FU U.S. Army 6.2, Environmental Quality and Installations Research Program,
Focus Area: Impact of Munitions Constituents on Biological Networks;
Alexander von Humboldt Stiftung; U.S. National Science Foundation; U.S.
Environmental Protection Agency [EF 0830117]
FX We thank Jennifer Laird for technical assistance generating data in the
ERDC laboratory. We acknowledge valuable discussions of DEB models with
Tin Klanjscek, Ben Martin, and Laure Pecquerie. We thank Thomas Preuss
for access to unpublished data. The research was supported by U.S. Army
6.2, Environmental Quality and Installations Research Program, Focus
Area: Impact of Munitions Constituents on Biological Networks. There was
also support to B. Ananthasubramaniam from the Alexander von Humboldt
Stiftung, and to R. M. Nisbet from the U.S. National Science Foundation
and the U.S. Environmental Protection Agency under Cooperative Agreement
Number EF 0830117. Any opinions, findings, and conclusions or
recommendations expressed in this material are those of the authors and
do not necessarily reflect the views of the National Science Foundation
or the U.S. Environmental Protection Agency.
NR 109
TC 3
Z9 3
U1 8
U2 30
PU ECOLOGICAL SOC AMER
PI WASHINGTON
PA 1990 M STREET NW, STE 700, WASHINGTON, DC 20036 USA
SN 1051-0761
EI 1939-5582
J9 ECOL APPL
JI Ecol. Appl.
PD SEP
PY 2015
VL 25
IS 6
BP 1691
EP 1710
DI 10.1890/14-0498.1
PG 20
WC Ecology; Environmental Sciences
SC Environmental Sciences & Ecology
GA CQ7VI
UT WOS:000360813100021
PM 26552275
ER
PT J
AU Joshi, U
Zheng, ZL
Shrestha, A
Henein, N
Sattler, E
AF Joshi, Umashankar
Zheng, Ziliang
Shrestha, Amit
Henein, Naeim
Sattler, Eric
TI An Investigation on Sensitivity of Ignition Delay and Activation Energy
in Diesel Combustion
SO JOURNAL OF ENGINEERING FOR GAS TURBINES AND POWER-TRANSACTIONS OF THE
ASME
LA English
DT Article
ID ENGINE; BIODIESEL; FUELS
AB The auto-ignition process plays a major role in the combustion, performance, fuel economy, and emission in diesel engines. The auto-ignition quality of different fuels has been rated by its cetane number (CN) determined in the cooperative fuel research engine, according to ASTM D613. More recently, the ignition quality tester (IQT), a constant volume vessel, has been used to determine the derived cetane number (DCN) to avoid the elaborate, time consuming, and costly engine tests, according to ASTM D6890. The ignition delay (ID) period in these two standard tests and many investigations has been considered to be the time period between start of injection (SOI) and start of combustion (SOC). The ID values determined in different investigations can vary due to differences in instrumentation and definitions. This paper examines the different definitions and the parameters that effect ID period. In addition, the activation energy dependence on the ID definition is investigated. Furthermore, results of an experimental investigation in a single-cylinder research diesel engine will be presented, while the charge density is kept constant during the ID period. The global activation energy is determined and its sensitivity to the charge temperature is examined.
C1 [Joshi, Umashankar; Zheng, Ziliang; Shrestha, Amit; Henein, Naeim] Wayne State Univ, Dept Mech Engn, Detroit, MI 48202 USA.
[Sattler, Eric] US Army RDECOM TARDEC, Warren, MI 48092 USA.
RP Joshi, U (reprint author), Wayne State Univ, Dept Mech Engn, 5050 Anthony Wayne Dr,Suite 2100, Detroit, MI 48202 USA.
EM umashankar.joshi84@gmail.com; zhengziliang@gmail.com;
sthamit7@gmail.com; henein@wayne.edu
FU U.S. Army TARDEC; Automotive Research Center (ARC): A U.S. Army Center
of Excellence for Modeling and Simulation of Ground Vehicles
FX The authors are grateful to the sponsors of the project, U.S. Army
TARDEC and Automotive Research Center (ARC): A U.S. Army Center of
Excellence for Modeling and Simulation of Ground Vehicles, led by
University of Michigan.
NR 27
TC 1
Z9 1
U1 1
U2 6
PU ASME
PI NEW YORK
PA TWO PARK AVE, NEW YORK, NY 10016-5990 USA
SN 0742-4795
EI 1528-8919
J9 J ENG GAS TURB POWER
JI J. Eng. Gas. Turbines Power-Trans. ASME
PD SEP
PY 2015
VL 137
IS 9
AR 091506
DI 10.1115/1.4029777
PG 8
WC Engineering, Mechanical
SC Engineering
GA CQ4BH
UT WOS:000360548600007
ER
PT J
AU Painter, EE
Deyle, GD
Allen, C
Petersen, EI
Croy, T
Rivera, KP
AF Painter, Elizabeth E.
Deyle, Gail D.
Allen, Christopher
Petersen, Evan I.
Croy, Theodore
Rivera, Kenneth P.
TI Manual Physical Therapy Following Immobilization for Stable Ankle
Fracture: A Case Series
SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY
LA English
DT Article
DE clinical reasoning; lower extremity; manipulation; mobilization
ID RANDOMIZED CLINICAL-TRIAL; TIBIOFIBULAR JOINT MANIPULATION; PAIN
RATING-SCALE; MUSCLE ADAPTATIONS; FUNCTIONAL SCALE; EXERCISE THERAPY;
HOME EXERCISE; OSTEOARTHRITIS; INSTABILITY; RANGE
AB STUDY DESIGN: Case series.
BACKGROUND: Ankle fractures commonly result in persistent pain, stiffness, and functional impairments. There is insufficient evidence to favor any particular rehabilitation approach after ankle fracture. The purpose of this case series was to describe an impairment-based manual physical therapy approach to treating patients with conservatively managed ankle fractures.
CASE DESCRIPTION: Patients with stable ankle fractures postimmobilization were treated with manual physical therapy and exercise targeted at associated impairments in the lower limb. The primary outcome measure was the Lower Extremity Functional Scale. Secondary outcome measures included the ankle lunge test, numeric pain-rating scale, and global rating of change. Outcome measures were collected at baseline (performed within 7 days of immobilization removal) and at 4 and 12 weeks postbaseline.
OUTCOMES: Eleven patients (mean age, 39.6 years; range, 18-64 years; 2 male), after ankle fracture-related immobilization (mean duration, 48 days; range, 21-75 days), were treated for an average of 6.6 sessions (range, 3-10 sessions) over a mean of 46.1 days (range, 13-81 days). Compared to baseline, statistically significant and clinically meaningful improvements were observed in Lower Extremity Functional Scale score (P = .001; mean change, 21.9 points; 95% confidence interval: 10.4, 33.4) and in the ankle lunge test (P = .001; mean change, 7.8 cm; 95% confidence interval: 3.9, 11.7) at 4 weeks. These changes persisted at 12 weeks.
DISCUSSION: Statistically significant and clinically meaningful improvements in self-reported function and ankle range of motion were observed at 4 and 12 weeks following treatment with impairment-based manual physical therapy. All patients tolerated treatment well. Results suggest that this approach may have efficacy in this population.
LEVEL OF EVIDENCE: Therapy, level 4.
C1 [Painter, Elizabeth E.; Deyle, Gail D.; Allen, Christopher] Army Baylor Univ Doctoral Fellowship Orthopaed Ma, Brooke Army Med Ctr, Ft Sam Houston, TX USA.
[Petersen, Evan I.] Univ Incarnate Word, Sch Phys Therapy, San Antonio, TX USA.
[Croy, Theodore] US Army Baylor Univ Doctoral Program Phys Therapy, Ft Sam Houston, TX USA.
[Rivera, Kenneth P.] US Army Baylor Univ, Brooke Army Med Ctr, Phys Assistant Postgrad Doctoral Program, Ft Sam Houston, TX USA.
RP Painter, EE (reprint author), CPT Jennifer M Moreno Primary Care Clin, Phys Therapy Serv, 3100 Schofield Rd, Ft Sam Houston, TX 78234 USA.
EM Elizabeth.e.painter@gmail.com
NR 54
TC 0
Z9 0
U1 2
U2 8
PU J O S P T,
PI ALEXANDRIA
PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA
SN 0190-6011
J9 J ORTHOP SPORT PHYS
JI J. Orthop. Sports Phys. Ther.
PD SEP
PY 2015
VL 45
IS 9
BP 665
EP 674
DI 10.2519/jospt.2015.5981
PG 10
WC Orthopedics; Rehabilitation; Sport Sciences
SC Orthopedics; Rehabilitation; Sport Sciences
GA CQ7KI
UT WOS:000360782600004
PM 26161627
ER
PT J
AU Howell, A
Pruziner, A
Andrews, A
AF Howell, Allison
Pruziner, Alison
Andrews, Anne
TI Use of Predictive Energy Expenditure Equations in Individuals with Lower
Limb Loss at Seated Rest
SO JOURNAL OF THE ACADEMY OF NUTRITION AND DIETETICS
LA English
DT Article
DE Energy expenditure; Amputation; Lower extremity; Limb loss
ID TRANS-TIBIAL AMPUTEES; METABOLIC-RATE; PARENTERAL-NUTRITION; VALIDATION;
AMBULATION; WEIGHT; ADULTS; OBESE; COST; MASS
AB Background As a result of the global war on terrorism, there has been a significant increase in young service members with traumatic amputations. Few published data are available on metabolic requirements for young, active individuals after traumatic limb loss, especially lower limb loss.
Objective The purpose of this study was to determine which predictive energy equation best predicted resting energy expenditure (REE) in this population.
Methods One hundred service members, 50 with at least one traumatic lower limb loss and 50 without limb loss, completed this study. Mean (standard deviation [ SD]) age, height, and weight were 27.3 years (+/- 5.3), 178.5 cm (+/- 7.7), 86.5 kg (+/- 15.8) for those with limb loss; and 29.4 years (+/- 5.8), 179.1 cm (+/- 6.7), 85.9 kg (+/- 12.6) for those without. REE was measured using the Oxycon Mobile metabolic system (CareFusion). Measured REE was compared with the following REE equations: Mifflin-St Joer, Harris Benedict, Owen, 25 kcal/kg, and 30 kcal/kg.
Results All equations tended to underestimate or overestimate REE for both groups (P< 0.001); however, the 25 kcal/kg had a more even distribution of disagreement for individuals with limb loss and without (P = 0.100 and P = 0.308, respectively), with 52% within +/- 10%.
Conclusions The 25 kcal/kg best predicts REE for young, active individuals with or without limb loss. Future studies may determine that more appropriate equations are most useful for different subgroups of this population.
C1 [Howell, Allison] US Army, Nutr Educ, Ft Leonard Wood, MO USA.
[Howell, Allison] US Army, Ft Leonard Wood, MO USA.
[Pruziner, Alison; Andrews, Anne] Walter Reed Natl Mil Med Ctr, DoD VA, Extrem Trauma & Amputat Ctr Excellence, Bethesda, MD USA.
[Andrews, Anne] US Army, Walter Reed Natl Mil Med Ctr, Bethesda, MD USA.
RP Andrews, A (reprint author), 8901 Wisconsin Ave, Bethesda, MD 20889 USA.
EM Anneandrews18@gmail.com
FU Department of the US Army [W81XWH-06-2-0073]
FX This research at Walter Reed was sponsored by the Department of the US
Army under Award Number W81XWH-06-2-0073 to the Henry M. Jackson
Foundation for the Advancement of Military Medicine, Inc. The US Army
Medical Research Acquisition Activity, 820 Chandler St, Fort Detrick, MD
21702-5014, is the awarding and administering acquisition office. The
content of the information does not necessarily reflect the position or
the policy of the government, and no official endorsement should be
inferred. The view and opinions expressed in this presentation are those
of the authors and do not reflect the views of General Leonard Wood Army
Community Hospital, Walter Reed National Military Medical Center, the
Department of the Army, or the Department of Defense.
NR 30
TC 0
Z9 0
U1 2
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 2212-2672
EI 2212-2680
J9 J ACAD NUTR DIET
JI J. Acad. Nutr. Diet.
PD SEP
PY 2015
VL 115
IS 9
BP 1479
EP 1485
DI 10.1016/j.jand.2015.05.019
PG 7
WC Nutrition & Dietetics
SC Nutrition & Dietetics
GA CQ3KW
UT WOS:000360502000013
PM 26187046
ER
PT J
AU Yuffa, AJ
Gutierrez, Y
Sanz, JM
de la Osa, RA
Saiz, JM
Gonzalez, F
Moreno, F
Videen, G
AF Yuffa, Alex J.
Gutierrez, Yael
Sanz, Juan M.
Alcaraz de la Osa, Rodrigo
Saiz, Jose M.
Gonzalez, Francisco
Moreno, Fernando
Videen, Gorden
TI Frequency shift between near-and far-field scattering resonances in
dielectric particles
SO JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND
VISION
LA English
DT Article
AB The near-field electromagnetic scattering intensity resonances are redshifted in frequency with respect to their far-field counterparts. We derive simple, approximate, analytical formulas for this shift in the case of a plane wave interacting with a dielectric sphere. Numerical results comparing the approximate formulas to the numerically exact solutions show that the two are in good agreement. We also consider the Rayleigh limit of the formulas to gain more insight into the phenomenon. (C) 2015 Optical Society of America
C1 [Yuffa, Alex J.; Videen, Gorden] Army Res Lab, Computat & Informat Sci Directorate, Adelphi, MD 20783 USA.
[Gutierrez, Yael; Sanz, Juan M.; Alcaraz de la Osa, Rodrigo; Saiz, Jose M.; Gonzalez, Francisco; Moreno, Fernando; Videen, Gorden] Univ Cantabria, Dept Fis Aplicada, Grp Opt, Fac Ciencias, E-39005 Santander, Spain.
[Videen, Gorden] INTA, Madrid 28850, Spain.
RP Yuffa, AJ (reprint author), Army Res Lab, Computat & Informat Sci Directorate, Adelphi, MD 20783 USA.
EM ayuffa@gmail.com
RI Yuffa, Alex/B-5498-2014
OI Yuffa, Alex/0000-0002-3600-1131
FU Ministerio de Ciencia e Innovacion (MICINN) [FIS2013-45854-P]; U.S. Army
Research Laboratory (ARL) [W911NF-12-2-0019]; United States Army
International Technology Center Atlantic (USAITC-A) [W911NF-13-1-0245]
FX Ministerio de Ciencia e Innovacion (MICINN) (FIS2013-45854-P); U.S. Army
Research Laboratory (ARL) (W911NF-12-2-0019); United States Army
International Technology Center Atlantic (USAITC-A) (W911NF-13-1-0245).
NR 17
TC 3
Z9 3
U1 2
U2 8
PU OPTICAL SOC AMER
PI WASHINGTON
PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA
SN 1084-7529
EI 1520-8532
J9 J OPT SOC AM A
JI J. Opt. Soc. Am. A-Opt. Image Sci. Vis.
PD SEP 1
PY 2015
VL 32
IS 9
BP 1638
EP 1642
DI 10.1364/JOSAA.32.001638
PG 5
WC Optics
SC Optics
GA CQ7VH
UT WOS:000360813000007
PM 26367431
ER
PT J
AU Platts-Mills, JA
Babji, S
Bodhidatta, L
Gratz, J
Haque, R
Havt, A
McCormick, BJJ
McGrath, M
Olortegui, MP
Samie, A
Shakoor, S
Mondal, D
Lima, IFN
Hariraju, D
Rayamajhi, BB
Qureshi, S
Kabir, F
Yori, PP
Mufamadi, B
Amour, C
Carreon, JD
Richard, SA
Lang, D
Bessong, P
Mduma, E
Ahmed, T
Lima, AAAM
Mason, CJ
Zaidi, AKM
Bhutta, ZA
Kosek, M
Guerrant, RL
Gottlieb, M
Miller, M
Kang, G
Houpt, ER
AF Platts-Mills, James A.
Babji, Sudhir
Bodhidatta, Ladaporn
Gratz, Jean
Haque, Rashidul
Havt, Alexandre
McCormick, Benjamin J. J.
McGrath, Monica
Olortegui, Maribel Paredes
Samie, Amidou
Shakoor, Sadia
Mondal, Dinesh
Lima, Ila F. N.
Hariraju, Dinesh
Rayamajhi, Bishnu B.
Qureshi, Shahida
Kabir, Furqan
Yori, Pablo P.
Mufamadi, Brenda
Amour, Caroline
Carreon, J. Daniel
Richard, Stephanie A.
Lang, Dennis
Bessong, Pascal
Mduma, Esto
Ahmed, Tahmeed
Lima, Aldo A. A. M.
Mason, Carl J.
Zaidi, Anita K. M.
Bhutta, Zulfiqar A.
Kosek, Margaret
Guerrant, Richard L.
Gottlieb, Michael
Miller, Mark
Kang, Gagandeep
Houpt, Eric R.
CA MAL-ED Network Investigators
TI Pathogen-specific burdens of community diarrhoea in developing
countries: a multisite birth cohort study (MAL-ED)
SO LANCET GLOBAL HEALTH
LA English
DT Article
ID GLOBAL ENTERIC MULTICENTER; CHILDHOOD DIARRHEA; ATTRIBUTABLE RISK;
CHILDREN; DISEASE; GROWTH; MALNUTRITION; INFECTION; ETIOLOGY; SITE
AB Background Most studies of the causes of diarrhoea in low-income and middle-income countries have looked at severe disease in people presenting for care, and there are few estimates of pathogen-specific diarrhoea burdens in the community.
Methods We undertook a birth cohort study with not only intensive community surveillance for diarrhoea but also routine collection of non-diarrhoeal stools from eight sites in South America, Africa, and Asia. We enrolled children within 17 days of birth, and diarrhoeal episodes (defined as maternal report of three or more loose stools in 24 h, or one loose stool with visible blood) were identified through twice-weekly home visits by fieldworkers over a follow-up period of 24 months. Non-diarrhoeal stool specimens were also collected for surveillance for months 1-12, 15, 18, 21, and 24. Stools were analysed for a broad range of enteropathogens using culture, enzyme immunoassay, and PCR. We used the adjusted attributable fraction (AF) to estimate pathogen-specific burdens of diarrhoea.
Findings Between Nov 26, 2009, and Feb 25, 2014, we tested 7318 diarrhoeal and 24 310 non-diarrhoeal stools collected from 2145 children aged 0-24 months. Pathogen detection was common in non-diarrhoeal stools but was higher with diarrhoea. Norovirus GII (AF 5.2%, 95% CI 3.0-7.1), rotavirus (4.8%, 4.5-5.0), Campylobacter spp (3.5%, 0.4-6.3), astrovirus (2.7%, 2.2-3.1), and Cryptosporidium spp (2.0%, 1.3-2.6) exhibited the highest attributable burdens of diarrhoea in the first year of life. The major pathogens associated with diarrhoea in the second year of life were Campylobacter spp (7.9%, 3.1-12.1), norovirus GII (5.4%, 2.1-7.8), rotavirus (4.9%, 4.4-5.2), astrovirus (4.2%, 3.5-4.7), and Shigella spp (4.0%, 3.6-4.3). Rotavirus had the highest AF for sites without rotavirus vaccination and the fifth highest AF for sites with the vaccination. There was substantial variation in pathogens according to geography, diarrhoea severity, and season. Bloody diarrhoea was primarily associated with Campylobacter spp and Shigella spp, fever and vomiting with rotavirus, and vomiting with norovirus GII.
Interpretation There was substantial heterogeneity in pathogen-specific burdens of diarrhoea, with important determinants including age, geography, season, rotavirus vaccine usage, and symptoms. These findings suggest that although single-pathogen strategies have an important role in the reduction of the burden of severe diarrhoeal disease, the effect of such interventions on total diarrhoeal incidence at the community level might be limited.
C1 [Platts-Mills, James A.; Gratz, Jean; Guerrant, Richard L.; Houpt, Eric R.] Univ Virginia, Div Infect Dis & Int Hlth, Charlottesville, VA 22908 USA.
[Havt, Alexandre; Lima, Ila F. N.; Lima, Aldo A. A. M.] Univ Fed Ceara, Clin Res Unit, Fortaleza, Ceara, Brazil.
[Havt, Alexandre; Lima, Ila F. N.; Lima, Aldo A. A. M.] Univ Fed Ceara, Inst Biomed, Fortaleza, Ceara, Brazil.
[Haque, Rashidul; Mondal, Dinesh; Ahmed, Tahmeed] Int Ctr Diarrhoeal Dis Res, Dhaka 1000, Bangladesh.
[Babji, Sudhir; Hariraju, Dinesh; Kang, Gagandeep] Christian Med Coll & Hosp, Vellore, Tamil Nadu, India.
[Bodhidatta, Ladaporn; Rayamajhi, Bishnu B.; Mason, Carl J.] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand.
[Yori, Pablo P.; Kosek, Margaret] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Baltimore, MD USA.
[Olortegui, Maribel Paredes; Yori, Pablo P.; Kosek, Margaret] Asociac Benef PRISMA, Iquitos, Peru.
[Shakoor, Sadia; Qureshi, Shahida; Kabir, Furqan; Zaidi, Anita K. M.; Bhutta, Zulfiqar A.] Aga Khan Univ, Karachi, Pakistan.
[Samie, Amidou; Mufamadi, Brenda; Bessong, Pascal] Univ Venda, Thohoyandou, South Africa.
[Gratz, Jean; Amour, Caroline; Mduma, Esto] Haydom Lutheran Hosp, Haydom, Tanzania.
[Lang, Dennis; Gottlieb, Michael] Fdn Natl Inst Hlth, Bethesda, MD USA.
[McCormick, Benjamin J. J.; McGrath, Monica; Carreon, J. Daniel; Richard, Stephanie A.; Miller, Mark] NIH, Fogarty Int Ctr, Bethesda, MD 20892 USA.
RP Houpt, ER (reprint author), Univ Virginia, Div Infect Dis & Int Hlth, Charlottesville, VA 22908 USA.
EM erh6k@virginia.edu
RI Strand, Tor/D-9836-2016;
OI Strand, Tor/0000-0002-4038-151X; Lima de Moraes,
Milena/0000-0003-1222-8400
FU Bill & Melinda Gates Foundation; Foundation for the NIH; National
Institutes of Health, Fogarty International Center
FX The Etiology, Risk Factors and Interactions of Enteric Infections and
Malnutrition and the Consequences for Child Health and Development
Project (MAL-ED) is a collaborative project supported by the Bill &
Melinda Gates Foundation, the Foundation for the NIH, and the National
Institutes of Health, Fogarty International Center. The authors thank
the staff and participants of the MAL-ED Network Project for their
important contributions.
NR 36
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U1 5
U2 10
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 2214-109X
J9 LANCET GLOB HEALTH
JI Lancet Glob. Health
PD SEP
PY 2015
VL 3
IS 9
BP E564
EP E575
DI 10.1016/S2214-109X(15)00151-5
PG 12
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA CQ4FJ
UT WOS:000360559500022
PM 26202075
ER
PT J
AU Klein, N
Palma, P
Luzuriaga, K
Pahwa, S
Nastouli, E
Gibb, DM
Rojo, P
Borkowsky, W
Bernardi, S
Zangari, P
Calvez, V
Compagnucci, A
Wahren, B
Foster, C
Munoz-Fernandez, MA
De Rossi, A
Ananworanich, J
Pillay, D
Giaquinto, C
Rossi, P
AF Klein, Nigel
Palma, Paolo
Luzuriaga, Katherine
Pahwa, Savita
Nastouli, Eleni
Gibb, Diane M.
Rojo, Pablo
Borkowsky, William
Bernardi, Stefania
Zangari, Paola
Calvez, Vincent
Compagnucci, Alexandra
Wahren, Britta
Foster, Caroline
Angeles Munoz-Fernandez, Maria
De Rossi, Anita
Ananworanich, Jintanat
Pillay, Deenan
Giaquinto, Carlo
Rossi, Paolo
TI Early antiretroviral therapy in children perinatally infected with HIV:
a unique opportunity to implement immunotherapeutic approaches to
prolong viral remission
SO LANCET INFECTIOUS DISEASES
LA English
DT Article
ID IMMUNODEFICIENCY-VIRUS TYPE-1; HUMORAL IMMUNE-RESPONSES;
PLACEBO-CONTROLLED TRIAL; T-CELL RESPONSES; HIV-1-INFECTED CHILDREN;
LATENT RESERVOIR; RHESUS-MONKEYS; DOUBLE-BLIND; NEUTRALIZING ANTIBODIES;
VIROLOGICAL CONTROL
AB From the use of antiretroviral therapy to prevent mother-to-child transmission to the possibility of HIV cure hinted at by the Mississippi baby experience, paediatric HIV infection has been pivotal to our understanding of HIV pathogenesis and management. Daily medication and indefinite antiretroviral therapy is recommended for children infected with HIV. Maintenance of life-long adherence is difficult and the incidence of triple-class virological failure after initiation of antiretroviral therapy increases with time. This challenge shows the urgent need to define novel strategies to provide long-term viral suppression that will allow safe interruption of antiretroviral therapy without viral rebound and any associated complications. HIV-infected babies treated within a few days of birth have a unique combination of a very small pool of integrated viruses, a very high proportion of relatively HIV resistant naive T cells, and an unparalleled capacity to regenerate an immune repertoire. These features make this group the optimum model population to investigate the potential efficacy of immune-based therapies. If successful, these investigations could change the way we manage HIV infection.
C1 [Klein, Nigel] UCL, Inst Child Hlth, London WC1N 1EH, England.
[Nastouli, Eleni] UCL, Dept Virol, London WC1N 1EH, England.
[Luzuriaga, Katherine] Univ Massachusetts, Sch Med, Program Mol Med, Worcester, MA USA.
[Palma, Paolo; Bernardi, Stefania; Zangari, Paola; Rossi, Paolo] Childrens Hosp Bambino Gesu, Univ Dept Pediat, Unit Immune & Infect Dis, Rome, Italy.
[Pahwa, Savita] Univ Miami, Miller Sch Med, Dept Microbiol & Immunol, Miami Ctr AIDS Res, Miami, FL 33136 USA.
[Gibb, Diane M.] MRC, Clin Trials Unit, London, England.
[Rojo, Pablo] Hosp 12 Octubre, Dept Pediat, E-28041 Madrid, Spain.
[Borkowsky, William] NYU, Sch Med, New York, NY USA.
[Calvez, Vincent] Univ Paris 06, Paris, France.
[Calvez, Vincent] Hop La Pitie Salpetriere, Paris, France.
[Compagnucci, Alexandra] INSERM, Clin Trials & Infect Dis SC10 US019, Paris, France.
[Wahren, Britta] Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden.
[Foster, Caroline] Imperial Coll Healthcare Natl Hlth Serv Trust, London, England.
[Angeles Munoz-Fernandez, Maria] Hosp Gen Univ Gregorio Maranon, Dept Mol ImmunoBiol, Madrid, Spain.
[De Rossi, Anita] Univ Padua, Sect Oncol & Immunol, Dept Surg Oncol & Gastroenterol DiSCOG, Padua, Italy.
[De Rossi, Anita] Ist Oncol Veneto, Padua, Italy.
[Ananworanich, Jintanat] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA.
[Ananworanich, Jintanat] Henry M Jackson Fdn Adv Mil Med, Silver Spring, MD USA.
[Pillay, Deenan] Africa Ctr, Mtubatuba, Kwazulu Natal, South Africa.
[Giaquinto, Carlo] Univ Padua, Dept Womens & Childrens Hlth, Padua, Italy.
[Giaquinto, Carlo] Penta Fdn, Padua, Italy.
RP Klein, N (reprint author), UCL, Inst Child Hlth, 30 Guilford St, London WC1N 1EH, England.
EM n.klein@ucl.ac.uk; rossipa@uniroma2.it
RI De Rossi, Anita/L-3128-2015;
OI De Rossi, Anita/0000-0001-6435-7509; Bernardi,
Stefania/0000-0001-5672-0881; Palma, Paolo/0000-0002-3066-4719; Pillay,
Dorsamy/0000-0003-3640-2573
FU PENTA Foundation; Children Hospital Bambino Gesu
FX The work of the authors is supported by PENTA Foundation and by the
Children Hospital Bambino Gesu.
NR 80
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U1 2
U2 7
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1473-3099
EI 1474-4457
J9 LANCET INFECT DIS
JI Lancet Infect. Dis.
PD SEP
PY 2015
VL 15
IS 9
BP 1108
EP 1114
DI 10.1016/S1473-3099(15)00052-3
PG 7
WC Infectious Diseases
SC Infectious Diseases
GA CQ4AZ
UT WOS:000360547800038
PM 26187030
ER
PT J
AU Mayer, CI
AF Mayer, Ci-Iris
TI How Colleges Change: Understanding, Leading, and Enacting Change
SO REVIEW OF HIGHER EDUCATION
LA English
DT Book Review
C1 [Mayer, Ci-Iris] US Mil Acad, Strategy Policy & Assessment, West Point, NY 10010 USA.
RP Mayer, CI (reprint author), US Mil Acad, Strategy Policy & Assessment, West Point, NY 10010 USA.
NR 1
TC 0
Z9 0
U1 0
U2 0
PU JOHNS HOPKINS UNIV PRESS
PI BALTIMORE
PA JOURNALS PUBLISHING DIVISION, 2715 NORTH CHARLES ST, BALTIMORE, MD
21218-4363 USA
SN 0162-5748
EI 1090-7009
J9 REV HIGH EDUC
JI Rev. High. Educ.
PD FAL
PY 2015
VL 39
IS 1
BP 167
EP 170
PG 4
WC Education & Educational Research
SC Education & Educational Research
GA CQ7IX
UT WOS:000360777300011
ER
PT J
AU Kragh, JF
Wallum, TE
Aden, JK
Dubick, MA
Baer, DG
AF Kragh, John F., Jr.
Wallum, Timothy E.
Aden, James K., III
Dubick, Michael A.
Baer, David G.
TI Which Improvised Tourniquet Windlasses Work Well and Which Ones Won't?
SO WILDERNESS & ENVIRONMENTAL MEDICINE
LA English
DT Article
DE first aid; resuscitation; damage control; hemorrhage; trauma; shock
ID BATTLEFIELD
AB Objective.-Improvised tourniquets in first aid are recommended when no scientifically designed tourniquet is available. Windlasses for mechanical advantage can be a stick or pencil and can be used singly or multiply in tightening a tourniquet band, but currently there is an absence of empiric knowledge of how well such windlasses work. The purpose of the present study was to determine the performance of improvised tourniquets in their use by the type and number of windlasses to improve tourniquet practice.
Methods.-A simulated Leg Tourniquet Trainer was used as a manikin thigh to test the effectiveness of improvised tourniquets of a band-and-windlass design. Two users made 20 tests each with 3 types of windlasses. Tests started with 1 representative of a given type (eg, 1 pencil), then continued with increasing numbers of each windlass type until the user reached 100% effectiveness as determined by cessation of simulated blood flow. Windlass types included chopsticks, pencils, and craft sticks.
Results.-Effectiveness percentages in stopping bleeding were associated inversely with breakage percentages. Pulse stoppage percentages were associated inversely with breakage. The windlass turn numbers, time to stop bleeding, the number of windlasses, and the under-tourniquet pressure were associated inversely with breakage. The windlass type was associated with breakage; at 2 windlasses, only chopsticks were without breakage. Of those windlass types that broke, 20.7% were chopsticks, 26.1% were pencils, and 53.2% were craft sticks.
Conclusions.-A pair of chopsticks as an improvised tourniquet windlass worked better than pencils or craft sticks.
C1 [Kragh, John F., Jr.; Dubick, Michael A.] US Army Inst Surg Res, Damage Control Resuscitat, Jbsa Ft Sam Houston, TX 78234 USA.
[Wallum, Timothy E.] US Army Inst Surg Res, Burn Ctr, Jbsa Ft Sam Houston, TX 78234 USA.
[Aden, James K., III] US Army Inst Surg Res, Dept Stat, Jbsa Ft Sam Houston, TX 78234 USA.
[Baer, David G.] US Army Inst Surg Res, Res Directorate, Jbsa Ft Sam Houston, TX 78234 USA.
RP Kragh, JF (reprint author), US Army Inst Surg Res, 3698 Chambers Pass, Jbsa Ft Sam Houston, TX 78234 USA.
EM john.f.kragh.civ@mail.mil
FU internal USAISR fund; Defense Health Program fund
FX This project was funded with internal USAISR and Defense Health Program
funds. Dr. Harold Klemcke aided in manuscript preparation.
NR 10
TC 1
Z9 1
U1 0
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1080-6032
EI 1545-1534
J9 WILD ENVIRON MED
JI Wildern. Environ. Med.
PD SEP
PY 2015
VL 26
IS 3
BP 401
EP 405
PG 5
WC Public, Environmental & Occupational Health; Sport Sciences
SC Public, Environmental & Occupational Health; Sport Sciences
GA CQ7JX
UT WOS:000360781100020
PM 25771027
ER
PT J
AU Sethumadhavan, S
Waksman, A
Suozzo, M
Huang, YP
Eum, J
AF Sethumadhavan, Simha
Waksman, Adam
Suozzo, Matthew
Huang, Yipeng
Eum, Julianna
TI Trustworthy Hardware from Untrusted Components
SO COMMUNICATIONS OF THE ACM
LA English
DT Article
C1 [Sethumadhavan, Simha] Columbia Univ, Dept Comp Sci, New York, NY 10027 USA.
[Waksman, Adam] DE Shaw Grp, New York, NY USA.
[Waksman, Adam; Suozzo, Matthew; Huang, Yipeng; Eum, Julianna] Columbia Univ, New York, NY USA.
[Suozzo, Matthew] Chip Scan LLC, New York, NY USA.
[Eum, Julianna] US Mil Acad, Dept Elect Engn & Comp Sci, West Point, NY 10996 USA.
RP Sethumadhavan, S (reprint author), Columbia Univ, Dept Comp Sci, New York, NY 10027 USA.
EM simha@cs.columbia.edu; waksman@cs.columbia.edu; ms4249@columbia.edu;
yipeng@cs.columbia.edu; julianna.eum@usma.edu
FU Defense Advanced Research Projects Agency grant [FA 87501020253];
National Science Foundation CCF/SaTC Programs [1054844]; Alfred P. Sloan
Foundation
FX This work is supported by Defense Advanced Research Projects Agency
grant FA 87501020253 through the Clean Slate Security program and
National Science Foundation CCF/SaTC Programs grant 1054844 and a
fellowship from the Alfred P. Sloan Foundation. Opinions, findings,
conclusions, and recommendations expressed in this material are those of
the authors and do not necessarily reflect the views of the U.S.
government or commercial entities. Simha Sethumadhavan has a significant
financial interest in Chip Scan LLC, New York. We also wish to thank the
reviewers for their valuable feedback.
NR 24
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U1 0
U2 1
PU ASSOC COMPUTING MACHINERY
PI NEW YORK
PA 2 PENN PLAZA, STE 701, NEW YORK, NY 10121-0701 USA
SN 0001-0782
EI 1557-7317
J9 COMMUN ACM
JI Commun. ACM
PD SEP
PY 2015
VL 58
IS 9
BP 60
EP 71
DI 10.1145/2699412
PG 12
WC Computer Science, Hardware & Architecture; Computer Science, Software
Engineering; Computer Science, Theory & Methods
SC Computer Science
GA CP9KW
UT WOS:000360214000020
ER
PT J
AU Cecotti, H
Marathe, AR
Ries, AJ
AF Cecotti, Hubert
Marathe, Amar R.
Ries, Anthony J.
TI Optimization of Single-Trial Detection of Event-Related Potentials
Through Artificial Trials
SO IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
LA English
DT Article
DE Brain-computer interface (BCI); event-related potentials (ERPs); signal
detection; single-trial detection
ID BRAIN-COMPUTER-INTERFACE; P300; ALGORITHM
AB Goal: Many brain-computer interface (BCI) classification techniques rely on a large number of labeled brain responses to create efficient classifiers. A large database representing all of the possible variability in the signal is impossible to obtain in a short period of time, and prolonged calibration times prevent efficient BCI use. We propose to improve BCIs based on the detection of event-related potentials (ERPs) in two ways. Methods: First, we increase the size of the training database by considering additional deformed trials. The creation of the additional deformed trials is based on the addition of Gaussian noise, and on the variability of the ERP latencies. Second, we exploit the variability of the ERP latencies by combining decisions across multiple deformed trials. These new methods are evaluated on data from 16 healthy subjects participating in a rapid serial visual presentation task. Results: The results show a significant increase in the performance of single-trial detection with the addition of artificial trials, and the combination of decisions obtained from altered trials. When the number of trials to train a classifier is low, the proposed approach allows us improve performance from an AUC of 0.533 +/- 0.080 to 0.905 +/- 0.053. This improvement represents approximately an 80% reduction in classification error. Conclusion: These results demonstrate that artificially increasing the training dataset leads to improved single-trial detection. Significance: Calibration sessions can be shortened for BCIs based on ERP detection.
C1 [Cecotti, Hubert] Univ Ulster, Sch Comp & Intelligent Syst, Coleraine BT52 1SA, Londonderry, North Ireland.
[Marathe, Amar R.; Ries, Anthony J.] US Army, Human Res & Engn Directorate, Res Lab, Aberdeen Proving Ground, MD USA.
RP Cecotti, H (reprint author), Univ Ulster, Sch Comp & Intelligent Syst, Coleraine BT52 1SA, Londonderry, North Ireland.
EM hub20xx@hotmail.com
FU U.S. Army [W911NF-09-D-0001]; Office of the Secretary of Defense ARPI
program MIPR [DWAM31168]
FX This work was supported in parts by U.S. Army Prime Contract No,
W911NF-09-D-0001 and in part by the Office of the Secretary of Defense
ARPI program MIPR DWAM31168. Asterisk indicates corresponding author.
NR 28
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U1 0
U2 7
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 0018-9294
EI 1558-2531
J9 IEEE T BIO-MED ENG
JI IEEE Trans. Biomed. Eng.
PD SEP
PY 2015
VL 62
IS 9
BP 2170
EP 2176
DI 10.1109/TBME.2015.2417054
PG 7
WC Engineering, Biomedical
SC Engineering
GA CQ1XW
UT WOS:000360394900009
PM 25823030
ER
PT J
AU Jacobs, RN
Vasquez, MJ
Lennon, CM
Nozaki, C
Almeida, LA
Pellegrino, J
Arias, J
Taylor, C
Wissman, B
AF Jacobs, R. N.
Vasquez, M. Jaime
Lennon, C. M.
Nozaki, C.
Almeida, L. A.
Pellegrino, J.
Arias, J.
Taylor, C.
Wissman, B.
TI Dynamic Curvature and Stress Studies for MBE CdTe on Si and GaAs
Substrates
SO JOURNAL OF ELECTRONIC MATERIALS
LA English
DT Article; Proceedings Paper
CT US Workshop on the Physics and Chemistry of II-VI Materials
CY OCT 20-23, 2014
CL Baltimore, MD
SP US Army RDECOM CERDEC Night Vision & Elect Sensors Directorate, US Army Res Lab, US Army SMDC, Penn State Univ, US Navy Electro-Opt Ctr, Off Naval Res, AF Res Lab, Army Res Off, Minerals, Metal & Mat Soc
DE Stress; thin-film; curvature; HgCdTe; MBE; CdTe; Si; GaAs; alternate
substrate
ID MOLECULAR-BEAM EPITAXY; HETEROEPITAXY; HGCDTE
AB Infrared focal plane arrays (IRFPA) based on HgCdTe semiconductor alloys have been shown to be ideal for tactical and strategic applications. High density (> 1 M pixel), high operability HgCdTe detectors on large area, low-cost composite substrates, such as CdTe-buffered Si or GaAs, are envisioned for next-generation IRFPAs. Thermal expansion mismatch is among various material parameters that govern the structural properties of the final detector layer. It has previously been shown that thermal expansion mismatch plays the dominant role in the residual stress characteristics of these heteroepitaxial structures (Jacobs et al. in J Electron Mater 37:1480, 2008). The wafer curvature (bowing) resulting from residual stress, is a likely source of problems that may occur during subsequent processing. This includes cracking of the film and substrate during post-growth annealing processes or even certain characterization techniques. In this work, we examine dynamic curvature and stress during molecular beam epitaxy (MBE), of CdTe on Si and GaAs substrates. The effect of temperature changes on wafer curvature throughout the growth sequence is documented using a multi-beam optical sensor developed by K-Space Associates. This monitoring technique makes possible the study of growth sequences which employ annealing schemes and/or interlayers to influence the final residual stress state of the heteroepitaxial structures.
C1 [Jacobs, R. N.; Vasquez, M. Jaime; Lennon, C. M.; Nozaki, C.; Almeida, L. A.; Pellegrino, J.] US Army RDECOM, CERDEC Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA.
[Arias, J.] CACI Inc, Arlington, VA USA.
[Taylor, C.; Wissman, B.] K Space Associates Inc, Dexter, MI USA.
RP Jacobs, RN (reprint author), US Army RDECOM, CERDEC Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA.
EM info@us.army.mil
NR 15
TC 2
Z9 2
U1 3
U2 15
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0361-5235
EI 1543-186X
J9 J ELECTRON MATER
JI J. Electron. Mater.
PD SEP
PY 2015
VL 44
IS 9
BP 3076
EP 3081
DI 10.1007/s11664-015-3822-5
PG 6
WC Engineering, Electrical & Electronic; Materials Science,
Multidisciplinary; Physics, Applied
SC Engineering; Materials Science; Physics
GA CQ0TX
UT WOS:000360311300018
ER
PT J
AU Benson, JD
Bubulac, LO
Jaime-Vasquez, M
Lennon, CM
Smith, PJ
Jacobs, RN
Markunas, JK
Almeida, LA
Stoltz, A
Arias, JM
Wijewarnasuriya, PS
Peterson, J
Reddy, M
Vilela, MF
Johnson, SM
Lofgreen, DD
Yulius, A
Carmody, M
Hirsch, R
Fiala, J
Motakef, S
AF Benson, J. D.
Bubulac, L. O.
Jaime-Vasquez, M.
Lennon, C. M.
Smith, P. J.
Jacobs, R. N.
Markunas, J. K.
Almeida, L. A.
Stoltz, A.
Arias, J. M.
Wijewarnasuriya, P. S.
Peterson, J.
Reddy, M.
Vilela, M. F.
Johnson, S. M.
Lofgreen, D. D.
Yulius, A.
Carmody, M.
Hirsch, R.
Fiala, J.
Motakef, S.
TI As-Received CdZnTe Substrate Contamination
SO JOURNAL OF ELECTRONIC MATERIALS
LA English
DT Article; Proceedings Paper
CT US Workshop on the Physics and Chemistry of II-VI Materials
CY OCT 20-23, 2014
CL Baltimore, MD
SP US Army RDECOM CERDEC Night Vision & Elect Sensors Directorate, US Army Res Lab, US Army SMDC, Penn State Univ, US Navy Electro-Opt Ctr, Off Naval Res, AF Res Lab, Army Res Off, Minerals, Metal & Mat Soc
DE CdZnTe substrate; molecular beam epitaxy; Te precipitate/inclusion;
polishing damage; impurity contamination
ID DUAL-BAND HGCDTE; DEFECTS; TE; THERMOMIGRATION; DEPOSITION; (HG,CD)TE;
CRYSTALS; QUALITY; IMPACT
AB State-of-the-art as-received (112)B CdZnTe substrates were examined for surface impurity contamination, polishing damage, and tellurium precipitates/inclusions. A maximum surface impurity concentration of Al = 7.5 x 10(14), Si = 3.7 x 10(13), Cl = 3.12 x 10(15), S = 1.7 x 10(14), P = 7.1 x 10(13), Fe = 1.0 x 10(13), Br = 1.9 x 10(12), and Cu = 4 x 10(12) atoms cm(-2) was observed on an as-received 6 x 6 cm wafer. As-received CdZnTe substrates have scratches and residual polishing grit on the (112)B surface. Polishing scratches are 0.3 nm in depth and 0.1 mu m wide. The polishing grit density was observed to vary from wafer-to-wafer from similar to 5 x 10(6) to 2 x 10(8) cm(-2). Te precipitate/inclusion size and density was determined by near-infrared automated microscopy. A Te precipitate/inclusion diameter histogram was obtained for the near-surface (top similar to 140 mu m) of a 6 x 6 cm substrate. The average areal Te precipitate/inclusion density was observed to be fairly uniform. However, there was a large density of Te precipitates/inclusions with a diameter significantly greater than the mean. Te precipitate/inclusion density > 10 mu m diameter = 2.8 x 10(3) cm(-3). The large Te precipitates/inclusions are laterally non-uniformly distributed across the wafer.
C1 [Benson, J. D.; Bubulac, L. O.; Jaime-Vasquez, M.; Lennon, C. M.; Smith, P. J.; Jacobs, R. N.; Markunas, J. K.; Almeida, L. A.; Stoltz, A.; Arias, J. M.] US Army RDECOM, CERDEC Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA.
[Wijewarnasuriya, P. S.] US Army Res Lab, Adelphi, MD USA.
[Peterson, J.; Reddy, M.; Vilela, M. F.; Johnson, S. M.; Lofgreen, D. D.] Raytheon Vis Syst, Goleta, CA USA.
[Yulius, A.; Carmody, M.; Hirsch, R.] Teledyne Imaging Sensors, Camarillo, CA USA.
[Fiala, J.; Motakef, S.] CapeSym Inc, Natick, MA USA.
RP Benson, JD (reprint author), US Army RDECOM, CERDEC Night Vis & Elect Sensors Directorate, Ft Belvoir, VA 22060 USA.
EM david.j.benson@us.army.mil
NR 16
TC 1
Z9 1
U1 6
U2 12
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0361-5235
EI 1543-186X
J9 J ELECTRON MATER
JI J. Electron. Mater.
PD SEP
PY 2015
VL 44
IS 9
BP 3082
EP 3091
DI 10.1007/s11664-015-3823-4
PG 10
WC Engineering, Electrical & Electronic; Materials Science,
Multidisciplinary; Physics, Applied
SC Engineering; Materials Science; Physics
GA CQ0TX
UT WOS:000360311300019
ER
PT J
AU Bommena, R
Ketharanathan, S
Wijewarnasuriya, PS
Dhar, NK
Kodama, R
Zhao, J
Buurma, C
Bergeson, JD
Aqariden, F
Velicu, S
AF Bommena, R.
Ketharanathan, S.
Wijewarnasuriya, P. S.
Dhar, N. K.
Kodama, R.
Zhao, J.
Buurma, C.
Bergeson, J. D.
Aqariden, F.
Velicu, S.
TI High-Performance MWIR HgCdTe on Si Substrate Focal Plane Array
Development
SO JOURNAL OF ELECTRONIC MATERIALS
LA English
DT Article; Proceedings Paper
CT US Workshop on the Physics and Chemistry of II-VI Materials
CY OCT 20-23, 2014
CL Baltimore, MD
SP US Army RDECOM CERDEC Night Vision & Elect Sensors Directorate, US Army Res Lab, US Army SMDC, Penn State Univ, US Navy Electro-Opt Ctr, Off Naval Res, AF Res Lab, Army Res Off, Minerals, Metal & Mat Soc
DE MBE; HgCdTe; MWIR; silicon; CdTe; dark current; FPA; NEDT
ID NUCLEATION; EPITAXY; ZNTE
AB The development of low noise-equivalent differential temperature (NEDT), high-operability midwave infrared (MWIR) focal plane arrays (FPAs) fabricated from molecular beam epitaxial (MBE)-grown HgCdTe on Si-based substrates is reported. High-quality n-type MWIR HgCdTe layers with a cutoff wavelength of 4.90 mu m at 77 K and a carrier concentration of 1-2 x 10(15) cm(-3) were grown on CdTe/Si substrates by MBE. Highly uniform composition and thickness over 3-inch areas were demonstrated, and low surface defect densities (voids similar to 5 x 10(2) cm(-2), micro-defects similar to 5 x 10(3) cm(-2)) and etch pit density (similar to 3.5 x 10(6) cm(-2)) were measured. This material was used to fabricate 320 x 256, 30 mu m pitch FPAs with planar device architecture; arsenic implantation was used to achieve p-type doping. Radiometric and noise characterization was also performed. A low NEDT of 13.8 m K at 85 K for a 1 ms integration time with f/#2 optics was measured. The NEDT operability was 99% at 120 K with a mean dark current noise of 8.14 x 10(-13) A/pixel. High-quality thermal images were obtained from the FPA up to a temperature of 150 K.
C1 [Bommena, R.; Ketharanathan, S.; Kodama, R.; Zhao, J.; Buurma, C.; Bergeson, J. D.; Aqariden, F.; Velicu, S.] EPIR Technol Inc, Bolingbrook, IL 60440 USA.
[Wijewarnasuriya, P. S.] Army Res Lab, Adelphi, MD USA.
[Dhar, N. K.] Night Vis & Elect Sensor Directorate, Ft Belvoir, VA USA.
RP Bommena, R (reprint author), EPIR Technol Inc, Bolingbrook, IL 60440 USA.
EM rbommena@epir.com
NR 7
TC 2
Z9 2
U1 0
U2 12
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0361-5235
EI 1543-186X
J9 J ELECTRON MATER
JI J. Electron. Mater.
PD SEP
PY 2015
VL 44
IS 9
BP 3151
EP 3156
DI 10.1007/s11664-015-3852-z
PG 6
WC Engineering, Electrical & Electronic; Materials Science,
Multidisciplinary; Physics, Applied
SC Engineering; Materials Science; Physics
GA CQ0TX
UT WOS:000360311300028
ER
PT J
AU VanZwieten, J
McAnally, W
Ahmad, J
Davis, T
Martin, J
Bevelhimer, M
Cribbs, A
Lippert, R
Hudon, T
Trudeau, M
AF VanZwieten, James
McAnally, William
Ahmad, Jameel
Davis, Trey
Martin, James
Bevelhimer, Mark
Cribbs, Allison
Lippert, Renee
Hudon, Thomas
Trudeau, Matthew
TI In-Stream Hydrokinetic Power: Review and Appraisal
SO JOURNAL OF ENERGY ENGINEERING
LA English
DT Article
DE Hydropower; Hydrokinetic; Streams; Tidal power; River power; Ocean
current energy; Marine renewable energy; In-stream hydro
ID COORDINATE OCEAN MODEL; ENERGY; CAVITATION; RESOURCE; TURBINES;
CURRENTS; SYSTEM; HYCOM
AB The objective of this paper is to provide a review of in-stream hydrokinetic power, which is defined as electric power generated by devices capturing the energy of naturally flowing water-stream, tidal, or open ocean flows-without impounding the water. North America has significant in-stream energy resources, and hydrokinetic electric power technologies to harness those resources have the potential to make a significant contribution to U.S. electricity needs by adding as much as 120 TWh/year from rivers alone to the present hydroelectric power generation capacity. Additionally, tidal and ocean current resources in the U.S. respectively contain 438 TWh/year and 163 TWh/year of extractable power. Among their attractive features, in-stream hydrokinetic operations do not contribute to greenhouse gas emissions or other air pollution and have less visual impact than wind turbines. Since these systems do no utilize dams the way traditional hydropower systems typically do, their impact on the environment will differ, and a small but growing number of studies support conclusions regarding those impacts. Potential environmental impacts include altered water quality, altered sediment deposition, altered habitats, direct impact on biota, and navigability of waterways. (C) 2014 American Society of Civil Engineers.
C1 [VanZwieten, James] Florida Atlantic Univ, Southeast Natl Marine Renewable Energy Ctr, Boca Raton, FL 33431 USA.
[McAnally, William] Mississippi State Univ, Geosyst Res Inst, Engn, Mississippi State, MS 39762 USA.
[Ahmad, Jameel] Cooper Union Coll, Dept Civil Engn, New York, NY 10003 USA.
[Ahmad, Jameel] Cooper Union Coll, George Fox Chair Urban Infrastruct, New York, NY 10003 USA.
[Davis, Trey] Wavelink Inc, Huntsville, AL 35806 USA.
[Davis, Trey] US Army, Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
[Martin, James] Mississippi State Univ, Dept Civil & Environm Engn, Mississippi State, MS 39762 USA.
[Bevelhimer, Mark] Oak Ridge Natl Lab, Div Environm Sci, Oak Ridge, TN 37831 USA.
[Cribbs, Allison] Ecomerit Technol, Santa Barbara, CA 93101 USA.
[Lippert, Renee] Florida Atlantic Univ, Dept Ocean & Mech Engn, Dania, FL 33004 USA.
[Hudon, Thomas] PCCI Inc, Alexandria, VA 22314 USA.
[Trudeau, Matthew] Boeing Co, Seattle, WA 98124 USA.
RP VanZwieten, J (reprint author), Florida Atlantic Univ, Southeast Natl Marine Renewable Energy Ctr, 777 Glades Rd, Boca Raton, FL 33431 USA.
EM jvanzwi@fau.edu; mcanally@ngi.msstate.edu; ahmad@cooper.edu;
trey.e.davis@us.army.mil; jmartin@cee.msstate.edu;
bevelhimerms@ornl.gov; acribbs@ecomerittech.com;
renee.lippert@gmail.com; thudon@pccii.com; mgtrudeau@gmail.com
NR 66
TC 1
Z9 1
U1 4
U2 52
PU ASCE-AMER SOC CIVIL ENGINEERS
PI RESTON
PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA
SN 0733-9402
EI 1943-7897
J9 J ENERG ENG
JI J. Energy Eng.-ASCE
PD SEP
PY 2015
VL 141
IS 3
AR 04014024
DI 10.1061/(ASCE)EY.1943-7897.0000197
PG 16
WC Energy & Fuels; Engineering, Civil
SC Energy & Fuels; Engineering
GA CP5SY
UT WOS:000359945900016
ER
PT J
AU Eakle, WL
Bond, L
Fuller, MR
Fischer, RA
Steenhof, K
AF Eakle, Wade L.
Bond, Laura
Fuller, Mark R.
Fischer, Richard A.
Steenhof, Karen
TI WINTERING BALD EAGLE COUNT TRENDS IN THE CONTERMINOUS UNITED STATES,
1986-2010
SO JOURNAL OF RAPTOR RESEARCH
LA English
DT Article
DE Bald Eagle; Haliaeetus leucocephalus; climate change; conterminous 48
states; population trends; survey; USA; wintering
ID SOUTHERN COLORADO; NEW-MEXICO; REPRODUCTION; POPULATION; WASHINGTON;
RECOVERY; RIVER; PRODUCTIVITY; MIGRATION; RESPONSES
AB We analyzed counts from the annual Midwinter Bald Eagle Survey to examine state, regional, and national trends in counts of wintering Bald Eagles (Haliaeetus leucocephalus) within the conterminous 48 United States from 1986 to 2010. Using hierarchical mixed model methods, we report trends in counts from 11 729 surveys along 844 routes in 44 states. Nationwide Bald Eagle counts increased 0.6% per yr over the 25-yr period, compared to an estimate of 1.9% per yr from 1986 to 2000. Trend estimates for Bald Eagles were significant (P <= 0.05) and positive in the northeastern and northwestern U.S. (3.9% and 1.1%, respectively), while trend estimates for Bald Eagles were negative (P <= 0.05) in the southwestern U.S. (-2.2%). After accounting for potential biases resulting from temporal and regional differences in surveys, we believe trends reflect post-DDT recovery and subsequent early effects of density-dependent population regulation.
C1 [Eakle, Wade L.] US Army Corps Engineers, South Pacific Div, San Francisco, CA 94103 USA.
[Bond, Laura] Boise State Univ, Biomol Res Ctr, Boise, ID 80525 USA.
[Fuller, Mark R.] US Geol Survey, Forest & Rangeland Ecosyst Sci Ctr, Boise, ID 83706 USA.
[Fuller, Mark R.] Boise State Univ, Raptor Res Ctr, Boise, ID 83725 USA.
[Fischer, Richard A.] US Army Engn Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA.
[Steenhof, Karen] Owyhee Desert Studies, Murphy, ID 83650 USA.
RP Eakle, WL (reprint author), US Army Corps Engineers, South Pacific Div, 1455 Market St, San Francisco, CA 94103 USA.
EM Wade.L.Eakle@usace.army.mil
FU American Eagle Foundation; Institutional Development Award (IDeA) from
the National Institute of General Medical Sciences of the National
Institutes of Health [P20RR016454]
FX The annual Midwinter Bald Eagle Survey has been completed by thousands
of conservation agency personnel and private volunteer "citizen
scientists'' over the years. Without their cooperation and commitment to
Bald Eagle conservation and long-term data collection, these records
would not have been possible. In addition, state coordinators in 44
states participated in the Midwinter Bald Eagle Survey since 1979 and
accomplished most of the "heavy lifting'' by organizing the counts each
year and providing count data to the national coordinators. The
Northwest Alliance for Computational Science and Engineering (NACSE) at
Oregon State University, Corvallis, provided database management
services and hosts and maintains the public Midwinter Bald Eagle Survey
website and online data entry site used by state coordinators. In
particular, Dylan Keon at NACSE provided critical support. The American
Eagle Foundation provided a Bald Eagle Grant to NACSE in 2012-13,
facilitating the completion of our 25-yr analysis. Kirk Bates, Lynda
Leppert, and Leah Dunn also provided important data management and
quality control services. Michael Guilfoyle, U.S. Army Engineer Research
& Development Center; Brian Millsap, U.S. Fish and Wildlife Service;
Cheryl Dykstra and three anonymous reviewers provided critical comments
on earlier drafts of this report. Pat Scheetz prepared the figure of the
study area. The contents of this report are not to be used for
advertising, publication, or promotional purposes. Citation of trade
names does not constitute an official endorsement or approval of the use
of such commercial products. All product names and trademarks cited are
the property of their respective owners. Any use of trade, product, or
firm names is for descriptive purposes only and does not imply
endorsement by the U.S. Government. The findings of this report are not
to be construed as an official Department of the Army position unless so
designated by other authorized documents. Research reported in this
publication was supported in part by an Institutional Development Award
(IDeA) from the National Institute of General Medical Sciences of the
National Institutes of Health under grant number P20RR016454.
NR 58
TC 0
Z9 0
U1 10
U2 31
PU RAPTOR RESEARCH FOUNDATION INC
PI HASTINGS
PA 14377 117TH STREET SOUTH, HASTINGS, MN 55033 USA
SN 0892-1016
EI 2162-4569
J9 J RAPTOR RES
JI J. Raptor Res.
PD SEP
PY 2015
VL 49
IS 3
BP 259
EP 268
PG 10
WC Ornithology
SC Zoology
GA CQ2SD
UT WOS:000360450500003
PM 26392679
ER
PT J
AU Jahanshad, N
Couture, MC
Prasitsuebsai, W
Nir, TM
Aurpibul, L
Thompson, PM
Pruksakaew, K
Lerdlum, S
Visrutaratna, P
Catella, S
Desai, A
Kerr, SJ
Puthanakit, T
Paul, R
Ananworanich, J
Valcour, VG
AF Jahanshad, Neda
Couture, Marie-Claude
Prasitsuebsai, Wasana
Nir, Talia M.
Aurpibul, Linda
Thompson, Paul M.
Pruksakaew, Kanchana
Lerdlum, Sukalaya
Visrutaratna, Pannee
Catella, Stephanie
Desai, Akash
Kerr, Stephen J.
Puthanakit, Thanyawee
Paul, Robert
Ananworanich, Jintanat
Valcour, Victor G.
CA SEARCH 012 Grp
PREDICT Study Grp
TI Brain Imaging and Neurodevelopment in HIV-uninfected Thai Children Born
to HIV-infected Mothers
SO PEDIATRIC INFECTIOUS DISEASE JOURNAL
LA English
DT Article
ID DEFERRED ANTIRETROVIRAL THERAPY; HUMAN-IMMUNODEFICIENCY-VIRUS;
WHITE-MATTER MICROSTRUCTURE; DIFFUSION-TENSOR MRI; CEREBRAL-CORTEX;
INFANTS BORN; RISK-FACTORS; EXPOSURE; OUTCOMES; REGISTRATION
AB Background:
Perinatal use of combination antiretroviral therapy dramatically reduces vertical (mother-to-child) transmission of HIV but has led to a growing population of children with perinatal HIV-exposure but uninfected (HEU). HIV can cause neurological injury among children born with infection, but the neuroanatomical and developmental effects in HEU children are poorly understood.
Methods:
We used structural magnetic resonance imaging with diffusion tensor imaging to compare brain anatomy between 30 HEU and 33 age-matched HIV-unexposed and uninfected (HUU) children from Thailand. Maps of brain volume and microstructural anatomy were compared across groups; associations were tested between neuroimaging measures and concurrent neuropsychological test performance.
Results:
Mean (standard deviation) age of children was 10.3 (2.8) years, and 58% were male. All were enrolled in school and lived with family members. Intelligence quotient (IQ) did not differ between groups. Caretaker education levels did not differ, but income was higher for HUU (P < 0.001). We did not detect group differences in brain volume or diffusion tensor imaging metrics, after controlling for sociodemographic factors. The mean (95% confidence interval) fractional anisotropy in the corpus callosum was 0.375 (0.368-0.381) in HEU compared with 0.370 (0.364-0.375) in HUU. Higher fractional anisotropy and lower mean diffusivity were each associated with higher IQ scores in analyses with both groups combined.
Conclusions:
No differences in neuroanatomical or brain integrity measures were detectable in HEU children compared with age-matched and sex-matched controls (HUU children). Expected associations between brain integrity measures and IQ scores were identified suggesting sufficient power to detect subtle associations that were present.
C1 [Jahanshad, Neda; Nir, Talia M.; Thompson, Paul M.] Univ So Calif, Imaging Genet Ctr, Stevens Neuroimaging & Informat Inst, Dept Neurol,Keck Sch Med USC, Marina Del Rey, CA USA.
[Couture, Marie-Claude] Univ San Francisco, Dept Publ Hlth, Fac Nursing & Hlth Profess, San Francisco, CA 94117 USA.
[Prasitsuebsai, Wasana; Pruksakaew, Kanchana; Kerr, Stephen J.; Puthanakit, Thanyawee; Ananworanich, Jintanat] Thai Red Cross AIDS Res Ctr, HIV NAT, Bangkok, Thailand.
[Aurpibul, Linda] Chiang Mai Univ, Res Inst Hlth Sci, Chiang Mai 50000, Thailand.
[Thompson, Paul M.] Univ So Calif, Dept Neurol Pediat Engn Psychiat Radiol & Ophthal, Los Angeles, CA USA.
[Lerdlum, Sukalaya; Puthanakit, Thanyawee; Ananworanich, Jintanat] Chulalongkorn Univ Hosp, Fac Med, Bangkok, Thailand.
[Visrutaratna, Pannee] Chiang Mai Univ, Fac Med, Dept Radiol, Chiang Mai 50000, Thailand.
[Catella, Stephanie; Desai, Akash; Valcour, Victor G.] Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA USA.
[Paul, Robert] Univ Missouri, Dept Psychol, St Louis, MO 63121 USA.
[Ananworanich, Jintanat] Walter Reed Army Inst Res, Mil HIV Res Program, Silver Spring, MD USA.
[Ananworanich, Jintanat] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA.
[Ananworanich, Jintanat; Valcour, Victor G.] SEARCH Thailand, Bangkok, Thailand.
[Valcour, Victor G.] Univ Calif San Francisco, Dept Geriatr Med, San Francisco, CA 94143 USA.
RP Jahanshad, N (reprint author), Keck Sch Med USC, Imaging Genet Ctr, Stevens Neuroimaging & Informat Inst, 4676 Admiralty Way,Suite 436, Marina Del Rey, CA 90292 USA.
EM neda.jahanshad@ini.usc.edu
FU [R01 MH089722]; [R01 HD050735]; [R01 AG040060]; [R01 MH097268];
[EB008432]; [EB008281]; [EB007813]; [U54EB020403]
FX This work was supported by grant R01 MH089722. N.J., T.M.N. and P.T.
were additionally supported by grants R01 HD050735, R01 AG040060, R01
MH097268, EB008432, EB008281, EB007813 (to P.T.) and U54EB020403 (to
P.T.). The authors have no conflicts of interest to disclose.
NR 58
TC 1
Z9 1
U1 5
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0891-3668
EI 1532-0987
J9 PEDIATR INFECT DIS J
JI Pediatr. Infect. Dis. J.
PD SEP
PY 2015
VL 34
IS 9
BP E211
EP E216
DI 10.1097/INF.0000000000000774
PG 6
WC Immunology; Infectious Diseases; Pediatrics
SC Immunology; Infectious Diseases; Pediatrics
GA CQ1ZN
UT WOS:000360399200002
PM 26090574
ER
PT J
AU Spengler, JR
Stonecipher, S
McManus, C
Hughes-Garza, H
Dow, M
Zoran, DL
Bissett, W
Beckham, T
Alves, DA
Wolcott, M
Tostenson, S
Dorman, B
Sidwa, TJ
Knust, B
Behravesh, CB
AF Spengler, Jessica R.
Stonecipher, Shelley
McManus, Catherine
Hughes-Garza, Holly
Dow, Max
Zoran, Debra L.
Bissett, Wesley
Beckham, Tammy
Alves, Derron A.
Wolcott, Mark
Tostenson, Samantha
Dorman, Bill
Sidwa, Thomas J.
Knust, Barbara
Behravesh, Casey Barton
TI Management of a pet dog after exposure to a human patient with Ebola
virus disease
SO JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION
LA English
DT Article
ID HEMORRHAGIC-FEVER; ASSAYS; ZAIRE
AB In October 2014, a health-care worker who had been part of the treatment team for the first laboratory-confirmed case of Ebola virus disease imported to the United States developed symptoms of Ebola virus disease. A presumptive positive reverse transcription PCR assay result for Ebola virus RNA in a blood sample from the worker was confirmed by the CDC, making this the first documented occurrence of domestic transmission of Ebola virus in the United States. The Texas Department of State Health Services commissioner issued a control order requiring disinfection and decontamination of the health-care worker's residence. This process was delayed until the patient's pet dog (which, having been exposed to a human with Ebola virus disease, potentially posed a public health risk) was removed from the residence. This report describes the movement, quarantine, care, testing, and release of the pet dog, highlighting the interdisciplinary, one-health approach and extensive collaboration and communication across local, county, state, and federal agencies involved in the response.
C1 [Spengler, Jessica R.; Knust, Barbara; Behravesh, Casey Barton] CDC, Natl Ctr Emerging & Zoonot Infect Dis, Atlanta, GA 30333 USA.
[Stonecipher, Shelley; Sidwa, Thomas J.] Texas Dept State Hlth Serv, Arlington, TX 76013 USA.
[McManus, Catherine] Dallas Anim Serv, Dallas, TX 75212 USA.
[Hughes-Garza, Holly; Dow, Max] Texas Anim Hlth Commiss, Austin, TX 78758 USA.
[Zoran, Debra L.; Bissett, Wesley] Texas A&M Univ, Coll Vet Med & Biomed Sci, Dept Small Anim Clin Sci, College Stn, TX 77843 USA.
[Beckham, Tammy] Inst Infect Anim Dis, Dept Homeland Secur, Sci & Technol Ctr Excellence, College Stn, TX 77845 USA.
[Alves, Derron A.] Def Hlth Headquarters, Def Hlth Agcy Vet Serv, Falls Church, VA 22042 USA.
[Wolcott, Mark; Tostenson, Samantha; Dorman, Bill] US Army, Med Res Inst Infect Dis, Special Pathogens Lab, Diagnost Syst Div, Ft Detrick, MD 21702 USA.
RP Behravesh, CB (reprint author), CDC, Natl Ctr Emerging & Zoonot Infect Dis, 1600 Clifton Rd NE, Atlanta, GA 30333 USA.
EM CBartonBehravesh@cdc.gov
OI Spengler, Jessica R./0000-0002-5383-0513
NR 24
TC 0
Z9 0
U1 0
U2 10
PU AMER VETERINARY MEDICAL ASSOC
PI SCHAUMBURG
PA 1931 N MEACHAM RD SUITE 100, SCHAUMBURG, IL 60173-4360 USA
SN 0003-1488
EI 1943-569X
J9 JAVMA-J AM VET MED A
JI JAVMA-J. Am. Vet. Med. Assoc.
PD SEP 1
PY 2015
VL 247
IS 5
BP 531
EP 538
PG 8
WC Veterinary Sciences
SC Veterinary Sciences
GA CP4ME
UT WOS:000359855400037
PM 26295560
ER
PT J
AU Kotan, H
Darling, KA
AF Kotan, Hasan
Darling, Kris A.
TI Isothermal Annealing of a Thermally Stabilized Fe-Based Ferritic Alloy
SO JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE
LA English
DT Article
DE Fe-based alloys; grain growth; intermetallics; isothermal annealing;
mechanical properties
ID GRAIN-SIZE STABILIZATION; MECHANICAL-PROPERTIES; NANOCRYSTALLINE
MATERIALS; SOLUTE SEGREGATION; ZR ALLOYS; GROWTH; IRON; ORIENTATION;
TEMPERATURE; ATTRITION
AB In this study, the stability and microstructural evolution, including grain size and hardness of nanocrystalline Fe91Ni8Zr1 alloyed powders, produced by ball milling, were investigated after annealing at 900 and 1000 A degrees C for up to 24 h. Results indicate that rapid grain growth to the micron scale occurs within the first few minutes of exposure to the elevated annealing temperatures. However, despite the loss of nanocrystallinity, an extremely stable and efficient hardening effect persists, which has been found to be equal to that predicted by Hall-Petch strengthening even at the smallest grain sizes. The mechanical properties of the samples consolidated to bulk via equal channel angular extrusion at 900 A degrees C were evaluated by uniaxial compression at room and elevated temperatures. Results reveal high compressive yield stress as well as the appearance and disappearance of a yield drop indicating the presence of coherent (GP zone like) precipitates within the microstructure. Such a hardening mechanism has implications for developing new Fe-Ni-based alloys exhibiting a combination of high strength and ductility for high temperature applications.
C1 [Kotan, Hasan] Konya Necmettin Erbakan Univ, Dept Met & Mat Engn, TR-42090 Konya, Turkey.
[Darling, Kris A.] US Army, Res Lab, Weap & Mat Res Directorate, RDRL WMM F, Aberdeen Proving Ground, MD 21005 USA.
RP Kotan, H (reprint author), Konya Necmettin Erbakan Univ, Dept Met & Mat Engn, TR-42090 Konya, Turkey.
EM hkotan@konya.edu.tr; krisdarling123@gmail.com
FU [BAP-142019001]
FX This work was supported partially by BAP-142019001. The author is
indebted with NanoMEGAS for ASTAR analyses and with U.S. Army Research
Laboratory for ECAE consolidation, compressive tests and FIB
investigations.
NR 35
TC 1
Z9 1
U1 5
U2 18
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1059-9495
EI 1544-1024
J9 J MATER ENG PERFORM
JI J. Mater. Eng. Perform.
PD SEP
PY 2015
VL 24
IS 9
BP 3271
EP 3276
DI 10.1007/s11665-015-1613-z
PG 6
WC Materials Science, Multidisciplinary
SC Materials Science
GA CP6QW
UT WOS:000360014000007
ER
PT J
AU Piermartiri, TCB
Pan, HB
Chen, J
McDonough, J
Grunberg, N
Apland, JP
Marini, AM
AF Piermartiri, Tetsade C. B.
Pan, Hongna
Chen, Jun
McDonough, John
Grunberg, Neil
Apland, James P.
Marini, Ann M.
TI Alpha-Linolenic Acid-Induced Increase in Neurogenesis is a Key Factor in
the Improvement in the Passive Avoidance Task After Soman Exposure
SO NEUROMOLECULAR MEDICINE
LA English
DT Article
DE Alpha-linolenic acid; Soman; Brain-derived neurotrophic factor (BDNF);
Rapamycin; Passive avoidance; Neurogenesis; mTORC1; Rat
ID TUBEROUS SCLEROSIS COMPLEX; POSTTRAUMATIC-STRESS-DISORDER;
POLYUNSATURATED FATTY-ACIDS; DENTATE GRANULE CELLS; NEUROTROPHIC FACTOR;
HIPPOCAMPAL NEUROGENESIS; ADULT NEUROGENESIS; INDUCED NEUROPATHOLOGY;
SYNAPTIC PLASTICITY; KAINIC ACID
AB Exposure to organophosphorous (OP) nerve agents such as soman inhibits the critical enzyme acetylcholinesterase (AChE) leading to excessive acetylcholine accumulation in synapses, resulting in cholinergic crisis, status epilepticus and brain damage in survivors. The hippocampus is profoundly damaged after soman exposure leading to long-term memory deficits. We have previously shown that treatment with three sequential doses of alpha-linolenic acid, an essential omega-3 polyunsaturated fatty acid, increases brain plasticity in na < ve animals. However, the effects of this dosing schedule administered after a brain insult and the underlying molecular mechanisms in the hippocampus are unknown. We now show that injection of three sequential doses of alpha-linolenic acid after soman exposure increases the endogenous expression of mature BDNF, activates Akt and the mammalian target of rapamycin complex 1 (mTORC1), increases neurogenesis in the subgranular zone of the dentate gyrus, increases retention latency in the passive avoidance task and increases animal survival. In sharp contrast, while soman exposure also increases mature BDNF, this increase did not activate downstream signaling pathways or neurogenesis. Administration of the inhibitor of mTORC1, rapamycin, blocked the alpha-linolenic acid-induced neurogenesis and the enhanced retention latency but did not affect animal survival. Our results suggest that alpha-linolenic acid induces a long-lasting neurorestorative effect that involves activation of mTORC1 possibly via a BDNF-TrkB-mediated mechanism.
C1 [Piermartiri, Tetsade C. B.] Uniformed Serv Univ Hlth Sci, Mol & Cellular Biol Grad Student Program, Bethesda, MD 20814 USA.
[Pan, Hongna; Chen, Jun; Marini, Ann M.] Uniformed Serv Univ Hlth Sci, Dept Neurol, Bethesda, MD 20814 USA.
[Pan, Hongna; Chen, Jun; Marini, Ann M.] Uniformed Serv Univ Hlth Sci, Program Neurosci, Bethesda, MD 20814 USA.
[McDonough, John] US Army, Med Res Inst Chem Def, Div Res, Pharmacol Branch, Aberdeen, MD 21010 USA.
[Grunberg, Neil] Uniformed Serv Univ Hlth Sci, Dept Med & Clin Psychol, Bethesda, MD 20814 USA.
[Apland, James P.] US Army, Med Res Inst Chem Def, Neurotoxicol Branch, Aberdeen, MD 21010 USA.
RP Marini, AM (reprint author), Uniformed Serv Univ Hlth Sci, Dept Neurol, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.
EM ann.marini@usuhs.edu
OI Piermartiri, Tetsade/0000-0002-9773-6983
FU Defense Threat Reduction Agency-Joint Science and Technology Office,
Medical ST Division [CBM.NEURO.01.10.US.012, CBM.NEURO.01.10.US.019]
FX This work was supported by the Defense Threat Reduction Agency-Joint
Science and Technology Office, Medical S&T Division (Grant Nos.
CBM.NEURO.01.10.US.012 and CBM.NEURO.01.10.US.019) to AMM.
NR 128
TC 2
Z9 2
U1 1
U2 1
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
SN 1535-1084
EI 1559-1174
J9 NEUROMOL MED
JI Neuromol. Med.
PD SEP
PY 2015
VL 17
IS 3
BP 251
EP 269
DI 10.1007/s12017-015-8353-y
PG 19
WC Neurosciences
SC Neurosciences & Neurology
GA CP0FW
UT WOS:000359552200003
PM 25920465
ER
PT J
AU Krishnani, KK
Boddu, VM
Moon, DH
Ghadge, SV
Sarkar, B
Brahmane, MP
Choudhary, K
Kathiravan, V
Meng, XG
AF Krishnani, Kishore K.
Boddu, Veera M.
Moon, Deok Hyun
Ghadge, S. V.
Sarkar, Biplab
Brahmane, M. P.
Choudhary, K.
Kathiravan, V.
Meng, Xiaoguang
TI Metals Bioaccumulation Mechanism in Neem Bark
SO BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
LA English
DT Article
DE Biomaterial; Characterization; Toxicants; Removal; Whewellite; Ion
exchange
ID AQUEOUS-SOLUTIONS; HEAVY-METALS; WHEAT BRAN; REMOVAL; IONS; ADSORPTION;
BIOSORPTION; SORPTION; BINDING; WASTE
AB The aim of this work was to define the bioaccumulation mechanism of metals onto the non-living biomaterial prepared from an extensively available plant bark biomass of neem (Azadirachta indica). Based on maximum ultimate fixation capacities (mmol/g) of the product, metals ions could be arranged as Hg2+ < Cd2+ < Pb2+ a parts per thousand... Cu2+. Surface properties of the biomaterial were characterized by X-ray photoelectron spectroscopy and X-ray diffraction techniques for their sorption mechanism. Whewellite (C2CaO4 center dot H2O) was identified in the biomaterial, which indicated that calcium ions are electrovalently bonded with carboxylate ions facilitating the ion exchange mechanism with metal ions. Bioaccumulation of metal ions was also studied by Fourier transform infrared spectroscopy, which indicated the presence of functional groups implicated in adsorbing metal ions. Biomaterial did not adsorb anionic As(III), As(V) and Cr(VI), because of their electrostatic repulsion with carboxylic functional groups. Neem bark can be used as bioindicators, bioaccumulators and biomonitors while determining environmental pressures. Metal bioaccumulative properties and structural investigation of plant bark has potential in providing quantitative information on the metal contamination in the surrounding environment.
C1 [Krishnani, Kishore K.; Ghadge, S. V.; Sarkar, Biplab; Brahmane, M. P.] Natl Inst Abiot Stress Management, Pune 413115, Maharashtra, India.
[Boddu, Veera M.] US Army, Construct Engn Res Labs, Champaign, IL USA.
[Moon, Deok Hyun] Chosun Univ, Dept Environm Engn, Kwangju 501759, South Korea.
[Choudhary, K.] Directorate Weed Sci Res, Jabalpur, India.
[Kathiravan, V.] Madura Coll, Madurai, TN, India.
[Meng, Xiaoguang] Stevens Inst Technol, CEE, Hoboken, NJ 07030 USA.
RP Krishnani, KK (reprint author), Natl Inst Abiot Stress Management, Pune 413115, Maharashtra, India.
EM krishnanik@hotmail.com
NR 24
TC 0
Z9 0
U1 2
U2 6
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0007-4861
EI 1432-0800
J9 B ENVIRON CONTAM TOX
JI Bull. Environ. Contam. Toxicol.
PD SEP
PY 2015
VL 95
IS 3
BP 414
EP 419
DI 10.1007/s00128-015-1609-2
PG 6
WC Environmental Sciences; Toxicology
SC Environmental Sciences & Ecology; Toxicology
GA CP2XO
UT WOS:000359741300022
PM 26193837
ER
PT J
AU Chang, ET
Ruhl, DS
Kenny, PR
Sniezek, JC
AF Chang, Edward T.
Ruhl, Douglas S.
Kenny, Patrick R.
Sniezek, Joseph C.
TI Endoscopic management of esophageal discontinuity
SO HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND
NECK
LA English
DT Article
DE esophageal transection; endoscopic transillumination;
esophagogastroduodenoscopy; panendoscopy; esophagoscopy
ID STAPLED INTRATHOROCIC ANASTOMOSIS; GASTRIC TUBE RECONSTRUCTION; SUTURED
NECK ANASTOMOSIS; THORACIC ANASTOMOSIS; STRICTURES; PERFORATIONS;
RESECTION
AB Background. The management of esophageal discontinuity remains challenging and often involves complex reconstructive surgeries.
Methods and Results. We describe a unique and successful treatment of esophageal discontinuity using a modification of the natural orifice translumenal surgery (NOTES) approach in a patient presenting with long-standing esophageal discontinuity resulting from an iatrogenic esophageal injury.
Conclusion. This case provided an opportunity to affirm the efficacy of endoscopy for treating esophageal discontinuities to minimize the degree of morbidity and mortality normally associated with the surgical treatment of this type of injury. Our case reveals a novel and possibly more direct means of evaluating and treating esophageal injuries in which the degree of discontinuity and/or stenosis initially remains unknown. (c) 2015 Wiley Periodicals, Inc.
C1 [Chang, Edward T.; Ruhl, Douglas S.; Sniezek, Joseph C.] Tripler Army Med Ctr, Dept Otolaryngol, Honolulu, HI 96859 USA.
[Kenny, Patrick R.] Tripler Army Med Ctr, Dept Gastroenterol, Honolulu, HI 96859 USA.
RP Chang, ET (reprint author), Tripler Army Med Ctr, Dept Otolaryngol, 1 Jarrett White Rd, Honolulu, HI 96859 USA.
EM etchan78@gmail.com
OI Ruhl, Douglas/0000-0002-7411-2385
NR 15
TC 0
Z9 0
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1043-3074
EI 1097-0347
J9 HEAD NECK-J SCI SPEC
JI Head Neck-J. Sci. Spec. Head Neck
PD SEP
PY 2015
VL 37
IS 9
BP E103
EP E105
DI 10.1002/hed.23883
PG 3
WC Otorhinolaryngology; Surgery
SC Otorhinolaryngology; Surgery
GA CP0ZN
UT WOS:000359605700001
PM 25270384
ER
PT J
AU Harvey, RE
Hart, EC
Charkoudian, N
Curry, TB
Carter, JR
Fu, Q
Minson, CT
Joyner, MJ
Barnes, JN
AF Harvey, Ronee E.
Hart, Emma C.
Charkoudian, Nisha
Curry, Timothy B.
Carter, Jason R.
Fu, Qi
Minson, Christopher T.
Joyner, Michael J.
Barnes, Jill N.
TI Oral Contraceptive Use, Muscle Sympathetic Nerve Activity, and Systemic
Hemodynamics in Young Women
SO HYPERTENSION
LA English
DT Article
DE blood pressure; follicular phase; hemodynamics; hypertension; oral
contraceptives
ID AMBULATORY BLOOD-PRESSURE; ENDOTHELIUM-DEPENDENT VASODILATION; PILL-FREE
INTERVAL; MENSTRUAL-CYCLE; NEURAL RESPONSES; BRACHIAL-ARTERY; HEALTHY
WOMEN; BAROREFLEX SENSITIVITY; HORMONAL CONTRACEPTION; ORTHOSTATIC
STRESS
AB Endogenous female sex hormones influence muscle sympathetic nerve activity (MSNA), a regulator of arterial blood pressure and important factor in hypertension development. Although approximate to 80% of American women report using hormonal contraceptives sometime during their life, the influence of combined oral contraceptives (OCs) on MSNA and systemic hemodynamics remains equivocal. The goal of this study was to determine whether women taking OCs have altered MSNA and hemodynamics (cardiac output and total peripheral resistance) at rest during the placebo phase of OC use compared with women with natural menstrual cycles during the early follicular phase. We retrospectively analyzed data from studies in which healthy, premenopausal women (aged 18-35 years) participated. We collected MSNA values at rest and hemodynamic measurements in women taking OCs (n=53; 25 +/- 4 years) and women with natural menstrual cycles (n=74; 25 +/- 4 years). Blood pressure was higher in women taking OCs versus those with natural menstrual cycles (mean arterial pressure, 89 +/- 1 versus 85 +/- 1 mm Hg, respectively; P=0.01), although MSNA was similar in both groups (MSNA burst incidence, 16 +/- 1 versus 18 +/- 1 bursts/100 heartbeats, respectively; P=0.19). In a subset of women in which detailed hemodynamic data were available, those taking OCs (n=33) had similar cardiac output (4.9 +/- 0.2 versus 4.7 +/- 0.2 L/min, respectively; P=0.47) and total peripheral resistance (19.2 +/- 0.8 versus 20.0 +/- 0.9 U, respectively; P=0.51) as women with natural menstrual cycles (n=22). In conclusion, women taking OCs have higher resting blood pressure and similar MSNA and hemodynamics during the placebo phase of OC use when compared with naturally menstruating women in the early follicular phase.
C1 [Harvey, Ronee E.; Curry, Timothy B.; Joyner, Michael J.; Barnes, Jill N.] Mayo Clin, Dept Anesthesiol, Rochester, MN 55905 USA.
[Hart, Emma C.] Univ Bristol, Sch Physiol & Pharmacol, Bristol, Avon, England.
[Charkoudian, Nisha] US Army Res Inst Environm Med, Thermal & Mt Med Div, Natick, MA USA.
[Carter, Jason R.] Michigan Technol Univ, Dept Kinesiol & Integrat Physiol, Houghton, MI 49931 USA.
[Fu, Qi] Univ Texas Southwestern Med Ctr, Texas Hlth Presbyterian Hosp Dallas, Inst Exercise & Environm Med, Dallas, TX 75390 USA.
[Minson, Christopher T.] Univ Oregon, Dept Human Physiol, Eugene, OR 97403 USA.
RP Harvey, RE (reprint author), Mayo Clin, Coll Med, 200 1st St SW,Mitchell Student Ctr 1-25, Rochester, MN 55905 USA.
EM harvey.ronee@mayo.edu
OI Hart, Emma/0000-0002-4534-9586
FU American Heart Association (AHA) [14PRE18040000]; NCATS [UL1 TR000135];
AHA [070036Z]; National Institutes of Health (NIH) [HL083947]; NIH
[HL083947, DK082424, HL088689, HL098676, K23 HL075283, HL10123, HL46493,
HL081671, HL118154, AG38067]
FX This work was supported by the American Heart Association (AHA)
14PRE18040000 and NCATS UL1 TR000135 (R.E. Harvey); AHA 070036Z (E.C.
Hart); National Institutes of Health (NIH) HL083947 (N. Charkoudian);
NIH DK082424 (T.B. Curry); NIH HL088689 and HL098676 (J.R. Carter); NIH
K23 HL075283 (Q. Fu); NIH HL10123, HL46493, and HL081671 (C.T. Minson);
NIH HL083947 (M.J. Joyner); and NIH HL118154 and AG38067 (J.N. Barnes).
NR 58
TC 7
Z9 7
U1 1
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0194-911X
EI 1524-4563
J9 HYPERTENSION
JI Hypertension
PD SEP
PY 2015
VL 66
IS 3
BP 590
EP 597
DI 10.1161/HYPERTENSIONAHA.115.05179
PG 8
WC Peripheral Vascular Disease
SC Cardiovascular System & Cardiology
GA CP1VO
UT WOS:000359664700022
PM 26101348
ER
PT J
AU Qu, Q
Nasrabadi, NM
Tran, TD
AF Qu, Qing
Nasrabadi, Nasser M.
Tran, Trac D.
TI Subspace Vertex Pursuit: A Fast and Robust Near-Separable Nonnegative
Matrix Factorization Method for Hyperspectral Unmixing
SO IEEE JOURNAL OF SELECTED TOPICS IN SIGNAL PROCESSING
LA English
DT Article
DE Linear mixture model; spectral unmixing; endmember extraction;
nonnegative matrix factorization (NMF); optimization; greedy pursuit
ID SPARSE REGRESSION; MIXTURE ANALYSIS; ALGORITHM; IMAGERY
AB The separability assumption turns the nonnegative matrix factorization (NMF) problem tractable, which coincides with the pure pixel assumption and provides new insights for the hyperspectral unmixing problem. Based on this assumption, and starting from the data self-expressiveness perspective, we formulate the unmixing problem as a joint sparse recovery problem by using the data itself as a dictionary. Moreover, we present a quasi-greedy algorithm for this problem by employing a back-tracking strategy. In comparison with the previous greedy methods, the proposed method can refresh the candidate pixels by solving a small fixed-scale convex sub-problem in every iteration. Therefore, our method has two important characteristics: (i) enhanced robustness against noise; (ii) moderate computational complexity and scalability to large dataset. Finally, computer simulations on both synthetic and real hyperspectral datasets demonstrate the effectiveness of the proposed method.
C1 [Qu, Qing] Columbia Univ, Dept Elect Engn, New York, NY 10027 USA.
[Nasrabadi, Nasser M.] US Army, Res Lab, Adelphi, MD 20783 USA.
[Tran, Trac D.] Johns Hopkins Univ, Dept Elect & Comp Engn, Baltimore, MD 21218 USA.
RP Qu, Q (reprint author), Columbia Univ, Dept Elect Engn, New York, NY 10027 USA.
EM qq2105@columbia.edu; nnasraba@arl.army.mil; trac@jhu.edu
FU National Science Foundation [CCF-1117545]; Army Research Office
[60219-MA]; Office of Naval Research [N000141210765]
FX This work was supported in part by the National Science Foundation under
Grant CCF-1117545, in part by the Army Research Office under Grant
60219-MA, and in part by the Office of Naval Research under Grant
N000141210765. The associate editor coordinating the review of this
manuscript and approving it for publication was Prof. Jose Bioucas-Dias.
NR 40
TC 2
Z9 2
U1 1
U2 7
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 1932-4553
EI 1941-0484
J9 IEEE J-STSP
JI IEEE J. Sel. Top. Signal Process.
PD SEP
PY 2015
VL 9
IS 6
BP 1142
EP 1155
DI 10.1109/JSTSP.2015.2419184
PG 14
WC Engineering, Electrical & Electronic
SC Engineering
GA CP0JP
UT WOS:000359561900016
ER
PT J
AU Dretsch, MN
Silverberg, ND
Iverson, GL
AF Dretsch, Michael N.
Silverberg, Noah D.
Iverson, Grant L.
TI Multiple Past Concussions Are Associated with Ongoing Post-Concussive
Symptoms but Not Cognitive Impairment in Active-Duty Army Soldiers
SO JOURNAL OF NEUROTRAUMA
LA English
DT Article
DE post-concussion symptoms; military; concussion; neurocognitive; PTSD
ID TRAUMATIC BRAIN-INJURY; PROFESSIONAL FOOTBALL PLAYERS;
POSTTRAUMATIC-STRESS-DISORDER; NEUROPSYCHOLOGICAL PERFORMANCE;
POSTCONCUSSIVE SYMPTOMS; RECURRENT CONCUSSION; IRAQI FREEDOM; HISTORY;
INSTRUMENT; TBI
AB The extent to which multiple past concussions are associated with lingering symptoms or mental health problems in military service members is not well understood. The purpose of this study was to examine the association between lifetime concussion history, cognitive functioning, general health, and psychological health in a large sample of fit-for-duty U.S. Army soldiers preparing for deployment. Data on 458 active-duty soldiers were collected and analyzed. A computerized cognitive screening battery (CNS-Vital Signs((R))) was used to assess complex attention (CA), reaction time (RT), processing speed (PS), cognitive flexibility (CF), and memory. Health questionnaires included the Neurobehavioral Symptom Inventory (NSI), PTSD Checklist-Military Version (PCL-M), Zung Depression and Anxiety Scales (ZDS; ZAS), Perceived Stress Scale (PSS), Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS), and the Alcohol Use and Dependency Identification Test (AUDIT). Soldiers with a history of multiple concussions (i.e., three or more concussions) had significantly greater post-concussive symptom scores compared with those with zero (d=1.83, large effect), one (d=0.64, medium effect), and two (d=0.64, medium effect) prior concussions. Although the group with three or more concussions also reported more traumatic stress symptoms, the results revealed that traumatic stress was a mediator between concussions and post-concussive symptom severity. There were no significant differences on neurocognitive testing between the number of concussions. These results add to the accumulating evidence suggesting that most individuals recover from one or two prior concussions, but there is a greater risk for ongoing symptoms if one exceeds this number of injuries.
C1 [Dretsch, Michael N.] US Army Aeromed Res Lab, Ft Rucker, AL USA.
[Dretsch, Michael N.] Walter Reed Natl Mil Med Ctr, Natl Intrepid Ctr Excellence, Bethesda, MD 20889 USA.
[Silverberg, Noah D.] Univ British Columbia, Div Phys Med & Rehabil, Vancouver, BC V5Z 1M9, Canada.
[Silverberg, Noah D.] GF Strong Rehab Ctr, Vancouver, BC, Canada.
[Iverson, Grant L.] Harvard Univ, Sch Med, Dept Phys Med & Rehabil, Boston, MA USA.
[Iverson, Grant L.] Red Sox Fdn, Boston, MA USA.
[Iverson, Grant L.] Massachusetts Gen Hosp, Home Base Program, Boston, MA 02114 USA.
[Iverson, Grant L.] Def & Vet Brain Injury Ctr, Bethesda, MD USA.
RP Dretsch, MN (reprint author), Walter Reed Natl Mil Med Ctr, Natl Intrepid Ctr Excellence, 4860 South Palmer Rd, Bethesda, MD 20889 USA.
EM Michael.n.dretsch.mil@mail.mil
FU U.S. Army Medical Research and Materiel Command; INTRuST Posttraumatic
Stress Disorder and Traumatic Brain Injury Clinical Consortium -
Department of Defense Psychological Health/Traumatic Brain Injury
Research Program [X81XWH-07-CC-CSDoD]; U.S. Army Aeromedical Research
Laboratory
FX The views expressed in this article are those of the authors and do not
reflect the official policy of the Department of Defense or the U.S.
government. Primary funding for this study was provided by the U.S. Army
Medical Research and Materiel Command (provided to Dr. Michael Dretsch
as the PI). Dr. Grant Iverson notes that this work was supported in part
by the INTRuST Posttraumatic Stress Disorder and Traumatic Brain Injury
Clinical Consortium funded by the Department of Defense Psychological
Health/Traumatic Brain Injury Research Program (X81XWH-07-CC-CSDoD). The
authors wish to thank the U.S. Army Aeromedical Research Laboratory for
its support during the time this study was conducted. Preliminary
findings from this study were presented at the 2014 Annual Military
Health System Research Symposium, Fort Lauderdale, FL.
NR 42
TC 2
Z9 2
U1 7
U2 20
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0897-7151
EI 1557-9042
J9 J NEUROTRAUM
JI J. Neurotrauma
PD SEP 1
PY 2015
VL 32
IS 17
BP 1301
EP 1306
DI 10.1089/neu.2014.3810
PG 6
WC Critical Care Medicine; Clinical Neurology; Neurosciences
SC General & Internal Medicine; Neurosciences & Neurology
GA CP0KP
UT WOS:000359564500003
PM 25763565
ER
PT J
AU Hsiao, MS
Cameron, KL
Tucker, CJ
Benigni, M
Blaine, TA
Owens, BD
AF Hsiao, Mark S.
Cameron, Kenneth L.
Tucker, Christopher J.
Benigni, Matthew
Blaine, Theodore A.
Owens, Brett D.
TI Shoulder impingement in the United States military
SO JOURNAL OF SHOULDER AND ELBOW SURGERY
LA English
DT Article
DE Shoulder; impingement; incidence; epidemiology; US military; DMED
ID SUPRASPINATUS TENDON; ROTATOR CUFF; RUPTURE; INJURY; EPIDEMIOLOGY;
DISLOCATION; POPULATION; DISORDERS; MEMBERS; SPORTS
AB Background: Little is known about the incidence and characteristics of primary, or external, shoulder impingement in an occupationally and physically active population. A longitudinal, prospective epidemiologic database was used to determine the incidence and risk factors for shoulder subacromial impingement in the United States (U.S.) military. Our hypothesis was that shoulder impingement is influenced by age, sex, race, military rank, and branch of service.
Methods: The Defense Medical Epidemiology Database was queried for all shoulder impingement injuries using International Classification of Disease, Ninth Addition, Clinical Modification code 726.10 within a 10-year period from 1999 through 2008. An overall injury incidence was calculated, and a multivariate analysis performed among demographic groups.
Results: In an at-risk population of 13,768,534 person-years, we identified 106,940 cases of shoulder impingement resulting in an incidence of 7.77/1000 person-years in the U.S. military. The incidence of shoulder impingement increased with age and was highest in the group aged >= 40 years (incidence rate ratio [IRR], 4.90; 95% confidence interval [CI], 4.61-5.21), was 9.5% higher among men (IRR, 1.10, 95% CI, 1.06-1.13), and compared with service members in the Navy, those in the Air Force, Army, and Marine Corps were associated with higher rates of shoulder impingement (IRR, 1.46 [95% CI, 1.42-1.50], 1.42 [95% CI, 1.39-1.46], and 1.31 [95% CI, 1.26-1.36], respectively).
Conclusions: The incidence of shoulder impingement among U.S. military personnel is 7.77/1000 person-years. An age of >= 40 years was a significant independent risk factor for injury. Published by Elsevier Inc. on behalf of Journal of Shoulder and Elbow Surgery Board of Trustees.
C1 [Hsiao, Mark S.] Texas Tech Univ, Hlth Sci Ctr, William Beaumont Army Med Ctr, Dept Orthopaed Surg & Rehabil, El Paso, TX USA.
[Cameron, Kenneth L.; Owens, Brett D.] Keller Army Hosp, John A Feagin Jr Sports Med Fellowship, Dept Orthopaed Surg, West Point, NY 10996 USA.
[Tucker, Christopher J.] Ft Belvoir Community Hosp, Dept Orthopaed & Rehabil, Ft Belvoir, VA USA.
[Benigni, Matthew] US Special Operat Command, MacDill Air Force Base, Tampa, FL USA.
[Blaine, Theodore A.] Yale Univ, Sch Med, Dept Orthopaed & Rehabil, Yale New Haven Hosp, New Haven, CT 06510 USA.
RP Owens, BD (reprint author), Keller Army Hosp, John A Feagin Jr Sports Med Fellowship, Dept Orthopaed Surg, West Point, NY 10996 USA.
EM b.owens@us.army.mil
OI Cameron, Kenneth/0000-0002-6276-4482
NR 32
TC 0
Z9 0
U1 2
U2 9
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1058-2746
J9 J SHOULDER ELB SURG
JI J. Shoulder Elbow Surg.
PD SEP
PY 2015
VL 24
IS 9
BP 1486
EP 1492
DI 10.1016/j.jse.2015.02.021
PG 7
WC Orthopedics; Sport Sciences; Surgery
SC Orthopedics; Sport Sciences; Surgery
GA CO9LI
UT WOS:000359496900026
PM 25865088
ER
PT J
AU Cheuvront, SN
Caruso, EM
Heavens, KR
Karis, AJ
Santee, WR
Troyanos, C
D'hemecourt, P
AF Cheuvront, Samuel N.
Caruso, Elizabeth M.
Heavens, Kristen R.
Karis, Anthony J.
Santee, William R.
Troyanos, Chris
D'hemecourt, Pierre
TI Effect of WBGT Index Measurement Location on Heat Stress Category
Classification
SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
LA English
DT Article
DE HEAT STRAIN; EXERCISE; WEATHER; MARATHON RUNNING
ID STANDARD METEOROLOGICAL MEASUREMENTS; GLOBE TEMPERATURE INDEX;
PERFORMANCE; MARATHON; WEATHER
AB The location of the wet bulb globe temperature (WBGT) index measurement may affect heat stress flag category classification. Purpose This study aimed to compare WBGT measurements at three locations along the Boston Marathon race course and compare WBGT estimates for meteorological stations and 72-h advanced WBGT forecasts.
Methods WBGT was measured hourly from 1000 to 1400 h at approximately 7 km, approximately 18 km, and approximately 30 km on the Boston Marathon race course. Simultaneous WBGT estimates were made for two meteorological stations southeast of the course via a commercial online system, which also provided 72-h advanced forecasts.
Results The measurement difference (mean SD) among course locations was 0.2 degrees C +/- 1.8 degrees C WBGT (ANOVA, P > 0.05). The difference between course and stations was 1.9 degrees C +/- 2.4 degrees C WBGT (t-test, P < 0.05). Station values underestimated (n = 98) or overestimated (n = 13) course values by >3 degrees C WBGT (>0.5 flag category) in 111 of 245 paired comparisons (45%). Higher black globe and lower wet bulb temperatures explained over- and underestimates, respectively. Significant underestimates of WBGT resulted in misclassification of green (labeled white) and black (labeled red) course flag categories ((2), P < 0.05). Forecast data significantly underestimated red (labeled amber) and black (labeled red) course flag categories.
Conclusions Differences in WBGT index along 23 km of the Boston Marathon race route can be small enough to warrant single measurements. However, significant misclassification of flag categories occurred using WBGT estimates for meteorological stations; thus, local measurements are preferred. If the relation between station WBGT forecasts and the race sites can be established, the forecast WBGT values could be corrected to give advanced warning of approximate flag conditions. Similar work is proposed for other venues to improve heat stress monitoring.
C1 [Cheuvront, Samuel N.; Caruso, Elizabeth M.; Heavens, Kristen R.; Karis, Anthony J.; Santee, William R.] US Army Res Inst Environm Med, Natick, MA 01760 USA.
[Troyanos, Chris; D'hemecourt, Pierre] Boston Athlet Assoc, Boston, MA USA.
RP Cheuvront, SN (reprint author), US Army Res Inst Environm Med, Thermal & Mt Med Div, Kansas St,Bldg 42, Natick, MA 01760 USA.
EM samuel.n.cheuvront.civ@mail.mil
FU United States Army Medical Research and Materiel Command
FX This work was funded by the United States Army Medical Research and
Materiel Command.
NR 25
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PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0195-9131
EI 1530-0315
J9 MED SCI SPORT EXER
JI Med. Sci. Sports Exerc.
PD SEP
PY 2015
VL 47
IS 9
BP 1958
EP 1964
DI 10.1249/MSS.0000000000000624
PG 7
WC Sport Sciences
SC Sport Sciences
GA CO9WR
UT WOS:000359527500023
PM 25628176
ER
PT J
AU Tarney, CM
Berry-Caban, C
Jain, RB
Kelly, M
Sewell, MF
Wilson, KL
AF Tarney, Christopher M.
Berry-Caban, Cristobal
Jain, Ram B.
Kelly, Molly
Sewell, Mark F.
Wilson, Karen L.
TI Association of Spouse Deployment on Pregnancy Outcomes in a US Military
Population
SO OBSTETRICS AND GYNECOLOGY
LA English
DT Article
ID SPONTANEOUS PRETERM BIRTH; GROUP PRENATAL-CARE; STRESS; DEPRESSION;
WEIGHT; ANXIETY; RISK
AB OBJECTIVE:To evaluate the association of spousal deployment during the antenatal period on maternal and neonatal outcomes and to estimate whether group prenatal care may be beneficial in reducing adverse outcomes when spouses are deployed.METHODS:Primigravid women who delivered at Womack Army Medical Center, Fort Bragg, North Carolina, were prospectively enrolled and selected for participation on a random basis between January 2013 and January 2014. Women whose spouses were deployed to a combat zone during the entire pregnancy (deployed group) were compared with women whose spouses were not deployed during the pregnancy (nondeployed group). Pregnancy and neonatal outcomes were compared between groups.RESULTS:Three hundred ninety-seven women were enrolled with 183 (46.1%) in the deployed group and 214 (53.9%) in the nondeployed group. Spouse deployment was associated with increased risk of preterm delivery (38 [20.8%] compared with 16 [7.5%], P<.001) and postpartum depression (30 [16.4%] compared with 13 [6.1%], P=.001) when compared with women in the nondeployed group. There were no differences in the incidence of preterm delivery and postpartum depression for women in the deployed group who participated in group prenatal care when compared with women participating in traditional care (preterm delivery 6 [14.6%] compared with 32 [22.5%], P=.38; postpartum depression 4 [9.8%] compared with 26 [18.3%], P=.24).CONCLUSION:Women who have a spouse deployed during their pregnancy are at increased risk for preterm birth and postpartum depression. Larger studies are needed to evaluate whether spouse deployment during pregnancy has other perinatal effects and whether group prenatal care may have a positive effect on adverse perinatal outcomes in this population.LEVEL OF EVIDENCE:II
C1 Womack Army Med Ctr, Dept Obstet & Gynecol, Div Maternal Fetal Med, Ft Bragg, NC 28307 USA.
Womack Army Med Ctr, Dept Gynecol, Div Maternal Fetal Med, Ft Bragg, NC 28307 USA.
RP Tarney, CM (reprint author), Womack Army Med Ctr, Dept Obstet & Gynecol, 2817 Reilly Rd, Ft Bragg, NC 28307 USA.
EM christopher.m.tarney.mil@mail.mil
NR 23
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U1 3
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0029-7844
J9 OBSTET GYNECOL
JI Obstet. Gynecol.
PD SEP
PY 2015
VL 126
IS 3
BP 569
EP 574
DI 10.1097/AOG.0000000000001003
PG 6
WC Obstetrics & Gynecology
SC Obstetrics & Gynecology
GA CP2KK
UT WOS:000359705700003
PM 26244533
ER
PT J
AU Taiyeb, AM
Ridha-Albarzanchi, MT
Haji, A
Mahmood, SN
Kjelland, ME
Hawa, NS
Muhsen-Alansarri, SA
AF Taiyeb, A. M.
Ridha-Albarzanchi, M. T.
Haji, A.
Mahmood, S. N.
Kjelland, M. E.
Hawa, N. S.
Muhsen-Alansarri, S. A.
TI IMPROVEMENT IN PREGNANCY RATES IN IMMUNOLOGICALLY INFERTILE MEN
UNDERGOING PREDNISOLONE AND IVF PROGRAMS PRECEDED BY SPERM PENETRATION
ASSAY.
SO FERTILITY AND STERILITY
LA English
DT Meeting Abstract
CT 71st Annual Meeting of the American-Society-for-Reproductive-Medicine
CY OCT 17-21, 2015
CL Baltimore, MD
SP Amer Soc Reprod Med
ID ANTISPERM ANTIBODIES; FERTILIZATION; SPERMATOZOA; THERAPY
C1 [Taiyeb, A. M.; Ridha-Albarzanchi, M. T.; Haji, A.; Muhsen-Alansarri, S. A.] BARZ IVF Ctr Infertil Treatment & Embro Res, Erbil, Iraq.
[Mahmood, S. N.; Hawa, N. S.] Baghdad Coll Med, Dept Obstet & Gynecol, Baghdad, Iraq.
[Kjelland, M. E.] US Army, Engn Res & Dev Ctr, Vicksburg, MS USA.
NR 9
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0015-0282
EI 1556-5653
J9 FERTIL STERIL
JI Fertil. Steril.
PD SEP
PY 2015
VL 104
IS 3
SU S
MA P-404
BP E243
EP E243
PG 1
WC Obstetrics & Gynecology; Reproductive Biology
SC Obstetrics & Gynecology; Reproductive Biology
GA DR6NP
UT WOS:000380018900660
ER
PT J
AU Sanchez, CJ
Shiels, SM
Tennent, DJ
Hardy, SK
Murray, CK
Wenke, JC
AF Sanchez, Carlos J., Jr.
Shiels, Stefanie M.
Tennent, David J.
Hardy, Sharanda K.
Murray, Clinton K.
Wenke, Joseph C.
TI Rifamycin Derivatives Are Effective Against Staphylococcal Biofilms In
Vitro and Elutable From PMMA
SO CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
LA English
DT Article
ID PROSTHETIC JOINT INFECTIONS; OPERATION ENDURING FREEDOM; OPEN TIBIA
FRACTURES; TO-DUTY RATES; RESISTANT STAPHYLOCOCCUS; ORTHOPEDIC
INFECTIONS; EPIDERMIDIS BIOFILMS; COMBINATION THERAPY; IRAQI FREEDOM;
BONE-CEMENT
AB Background Local antimicrobial delivery through polymethylmethacrylate beads (PMMA), commonly vancomycin, is used for the treatment of contaminated open fractures but has limited activity against Staphylococcus aureus biofilms, which occur commonly in such fractures. Rifamycins have activity against biofilms and are an effective treatment for osteoarticular infections involving staphylococcal biofilms, but there are limited studies evaluating the activity of rifamycin derivatives, other than rifampin, against biofilms of S. aureus and evaluating incorporation of these drugs into PMMA for treatment of contaminated open fractures.
Questions/purposes (1) Are rifamycin derivatives effective against established biofilms of clinical isolates of S. aureus? (2) Can PMMA be used as a carrier for rifamycin derivatives?
Methods Biofilms were developed and evaluated for susceptibility to a panel of antimicrobials in vitro using the minimum biofilm eradication concentration high-throughput model. Susceptibility was assessed by measuring bacterial recovery at 6 and 24 hours after antimicrobial treatment. Activity of rifamycin derivatives against intracellular bacteria was also evaluated using a gentamicin protection assay. Evaluation of PMMA as a carrier for rifampin and rifamycin derivatives was determined by assessing the curing time subsequent to loading of rifamycins and characterizing the release kinetics of rifamycins at daily intervals for 14 days from PMMA by performing bioassays.
Results Rifamycin derivatives between 1 and 8 lg/mL reduced bacteria within biofilms 5-to 9-logs and prevented bacterial recovery up to 24 hours post-treatment, indicating near to complete eradication of biofilms. Rifamycin derivatives at 32 lg/mL had activity against intracellular staphylococci, significantly reducing the number of internalized bacteria with limited effects on osteoblast viability. Rifampin was the only rifamycin observed to have a suitable release profile from PMMA, releasing 49% of the total antibiotic and maintaining a sustained released profile up to 14 days at a mean 28 +/- 6 mu g/mL.
Conclusions Rifampin can be incorporated into PMMA and eluted at concentrations effective against biofilms and intracellular staphylococci.
C1 [Sanchez, Carlos J., Jr.; Shiels, Stefanie M.; Tennent, David J.; Hardy, Sharanda K.; Wenke, Joseph C.] US Army Inst Surg Res, Extrem Trauma & Regenerat Med Task Area, JBSA, Ft Sam Houston, TX 78234 USA.
[Murray, Clinton K.] San Antonio Mil Med Ctr, Infect Dis Serv, Dept Med, Ft Sam Houston, TX USA.
RP Wenke, JC (reprint author), US Army Inst Surg Res, Extrem Trauma & Regenerat Med Task Area, JBSA, 3698 Chambers Pass, Ft Sam Houston, TX 78234 USA.
EM joseph.c.wenke.civ@mail.mil
OI Shiels, Stefanie/0000-0002-5904-3107
FU Combat Casualty Research Program, Medical Research and Materiel Command
FX This work was supported by intramural funding from the Combat Casualty
Research Program, Medical Research and Materiel Command to one of the
authors (JCW).
NR 60
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U1 0
U2 9
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0009-921X
EI 1528-1132
J9 CLIN ORTHOP RELAT R
JI Clin. Orthop. Rel. Res.
PD SEP
PY 2015
VL 473
IS 9
BP 2874
EP 2884
DI 10.1007/s11999-015-4300-3
PG 11
WC Orthopedics; Surgery
SC Orthopedics; Surgery
GA CO1TA
UT WOS:000358936900021
PM 25896136
ER
PT J
AU Yildirim, AA
Watson, D
Tarboton, D
Wallace, RM
AF Yildirim, Ahmet Artu
Watson, Dan
Tarboton, David
Wallace, Robert M.
TI A virtual tile approach to raster-based calculations of large digital
elevation models in a shared-memory system
SO COMPUTERS & GEOSCIENCES
LA English
DT Article
DE Multithreaded parallel digital elevation; model analysis; Pit filling
algorithm; User-level virtual memory management
ID EXTRACTION; ALGORITHM; DEPRESSIONS; NETWORKS
AB Grid digital elevation models (DEMs) are commonly used in hydrology to derive information related to topographically driven flow. Advances in technology for creating DEMs have increased their resolution and data size with the result that algorithms for processing them are frequently memory limited. This paper presents a new approach to the management of memory in the parallel solution of hydrologic terrain processing using a user-level virtual memory system for shared-memory multithreaded systems. The method includes tailored virtual memory management of raster-based calculations for datasets that are larger than available memory and a novel order-of-calculations approach to parallel hydrologic terrain analysis applications. The method is illustrated for the pit filling algorithm used first in most hydrologic terrain analysis workflows. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Yildirim, Ahmet Artu; Watson, Dan] Utah State Univ, Dept Comp Sci, Logan, UT 84322 USA.
[Tarboton, David] Utah State Univ, Utah Water Res Lab, Logan, UT 84322 USA.
[Wallace, Robert M.] US Army Engineer Res & Dev Ctr, Informat Technol Lab, Vicksburg, MS USA.
RP Yildirim, AA (reprint author), Utah State Univ, Dept Comp Sci, Logan, UT 84322 USA.
EM ahmetartu@aggiemail.usu.edu; dan.watson@usu.edu; dtarb@usu.edu;
robert.m.wallace@usace.army.mil
OI Tarboton, David/0000-0002-1998-3479
FU US Army Engineer Research and Development Center System-Wide Water
Resources Program [W912HZ-11-P-0338]
FX This research was supported by the US Army Engineer Research and
Development Center System-Wide Water Resources Program under contract
number W912HZ-11-P-0338. This support is gratefully acknowledged.
NR 29
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U2 5
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0098-3004
EI 1873-7803
J9 COMPUT GEOSCI-UK
JI Comput. Geosci.
PD SEP
PY 2015
VL 82
BP 78
EP 88
DI 10.1016/j.cageo.2015.05.014
PG 11
WC Computer Science, Interdisciplinary Applications; Geosciences,
Multidisciplinary
SC Computer Science; Geology
GA CO2FM
UT WOS:000358971500010
ER
PT J
AU Zhou, L
Kellogg, F
Hofmeister, C
Giri, A
Cho, K
Sohn, Y
AF Zhou, Le
Kellogg, Frank
Hofmeister, Clara
Giri, Anit
Cho, Kyu
Sohn, Yongho
TI Nanostructured tungsten through cryogenic attrition
SO INTERNATIONAL JOURNAL OF REFRACTORY METALS & HARD MATERIALS
LA English
DT Article
DE Nanocrystalline; Tungsten; Cryomilling; Microstructure; Grain size
ID WC-CO POWDER; MECHANICAL-PROPERTIES; HEAVY ALLOYS; GRAIN-SIZE;
THERMAL-STABILITY; HIGH-STRENGTH; MICROSTRUCTURE; TEMPERATURE;
COMPOSITES; BEHAVIOR
AB Nanostructured pure tungsten (W) powders have been fabricated through cryogenic attrition (i.e., cryomilling) in a liquid nitrogen medium for the first time. The microstructure and chemistry of W powders before and after 4 and 12 h of cryomilling were thoroughly examined by gas fusion chemical analysis, X-ray diffraction, scanning electron microscopy, and transmission electron microscopy (TEM). Cryomilling in liquid nitrogen protected the tungsten from oxygen and hydrogen contamination while introducing nitrogen. Results showed that the W grain size decreased with cryomilling time, and reached approximately 5 nm after 12 h of cryomilling. High resolution TEM suggested that nitrogen reacted with W to form tungsten nitride (WN). Additionally, amorphous W was identified in the 12 h cryomilled W powder. Tungsten carbide (WC) contamination from the milling media and minor Fe-Cr-Ni-containing impurities from the stainless steel vessel were also documented. The WC had grain size ranging from 20 nm to 150 nm, and was homogeneously dispersed in W matrix. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Zhou, Le; Hofmeister, Clara; Sohn, Yongho] Univ Cent Florida, Dept Mat Sci & Engn, Orlando, FL 32816 USA.
[Zhou, Le; Hofmeister, Clara; Sohn, Yongho] Univ Cent Florida, Adv Mat Proc & Anal Ctr, Orlando, FL 32816 USA.
[Kellogg, Frank] Bowhead Sci & Technol, Belcamp, MD 21017 USA.
[Giri, Anit] TKC Global, Herndon, VA 20171 USA.
[Giri, Anit; Cho, Kyu] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD 21005 USA.
RP Sohn, Y (reprint author), Univ Cent Florida, Dept Mat Sci & Engn, Orlando, FL 32816 USA.
EM Yongho.Sohn@ucf.edu
RI Sohn, Yongho/A-8517-2010; Zhou, Le/H-9531-2016
OI Sohn, Yongho/0000-0003-3723-4743; Zhou, Le/0000-0001-8327-6667
FU U.S. Army Research Laboratory [W911NF-11-2-0020]
FX This research was sponsored by the U.S. Army Research Laboratory through
cooperative agreement #W911NF-11-2-0020 between University of Central
Florida and the U.S. Army Research Laboratory. The views, opinions and
conclusions made in this document are those of the authors and should
not be interpreted as representing the official policies, either
expressed or implied, of the U.S. Army Research Laboratory or the U.S.
Government. The U.S. Government is authorized to reproduce and
distribute reprints for Government purposes notwithstanding any
copyright notation herein.
NR 45
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U1 1
U2 8
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0263-4368
J9 INT J REFRACT MET H
JI Int. J. Refract. Met. Hard Mat.
PD SEP
PY 2015
VL 52
BP 70
EP 77
DI 10.1016/j.ijrmhm.2015.05.016
PG 8
WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical
Engineering
SC Materials Science; Metallurgy & Metallurgical Engineering
GA CN7PC
UT WOS:000358625500012
ER
PT J
AU Florio, LA
AF Florio, L. A.
TI Direct modeling of coupled compressible flow and macroscopic particle
spread and particle ejection
SO MECCANICA
LA English
DT Article
DE Fluid-structure interaction; Computational fluid dynamics; Soft
collision model; Two-phase; Particle flow
ID NUMERICAL-SIMULATION; FORCE MODELS; COLLISIONS; SPHERES; ASSEMBLIES;
VISCOSITY; NUMBER; MOTION
AB Modeling methods were developed and implemented to provide the capabilities to investigate two phase coupled particle-high speed compressible gas flow under conditions where particle concentrations and particle sizes require particle interaction and local particle volume, motion and momentum effects to be taken into consideration. Rigid particles are directly incorporated into the computational domain. The particles translate and rotate through the fluid based on the flow induced forces, gravity forces, and interaction forces. A soft collision model is utilized to simulate the contact between the solid bodies. Parametric studies were conducted to investigate the particle spread in the direction perpendicular to the initial velocity of an array of particles moving in free space. An initially offset particle arrangement was found to create more distributed pressure/viscous forces and therefore less spread than an initially inline particle arrangement. The particles must initially be placed close enough together to influence the flow conditions over neighboring particles in order for the relative positioning of the particles (spread) to change significantly. The particle spread perpendicular to the initial particle motion also decreases with an increase in particle size and density, with the particle motion more sensitive to changes in the radius than the density. Another set of parametric studies was performed varying the particle size and number of particles for particle expulsion from a flow channel. The simulations illustrate the complex dependencies among the flow and particle motion drivers including the motion of the piston pushing the particles, the flow due to the high pressure gases leaking around the piston and moving between the particles, and the proximity and relative velocity of the particle compared to the surrounding particles/walls. The results indicate particle spread patterns upon expulsion tend to be greater for smaller particles and for larger numbers of particles. Such operating conditions lead to more intense and vigorous interactions between the particles, the flow channel surfaces, the moving piston plate, and the high velocity flow streams that are responsible for the higher spread. The work has demonstrated the utility of the modeling technique to explore phenomena associated with coupled larger particle-high speed compressible gas flow and provides a unique study of particle spread in compressible gas flow.
C1 US Army ARDEC, Technol Branch, Small Caliber Armaments Div, Picatinny Arsenal, NJ 07806 USA.
RP Florio, LA (reprint author), US Army ARDEC, Technol Branch, Small Caliber Armaments Div, Picatinny Arsenal, NJ 07806 USA.
EM laurie.a.florio.civ@mail.mil
FU ARDEC In-House Laboratory Independent Research Project
FX This work was funded by an ARDEC In-House Laboratory Independent
Research Project. This work was supported in part by a grant of computer
time from the DoD High Performance Computing Modernization Program at
ARL, AFRL, and ERDC.
NR 33
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U1 0
U2 11
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0025-6455
EI 1572-9648
J9 MECCANICA
JI Meccanica
PD SEP
PY 2015
VL 50
IS 9
BP 2257
EP 2291
DI 10.1007/s11012-015-0168-2
PG 35
WC Mechanics
SC Mechanics
GA CN8BH
UT WOS:000358661200004
ER
PT J
AU Mayer, C
AF Mayer, Chris
TI Modern Honor: A Philosophical Defense
SO JOURNAL OF VALUE INQUIRY
LA English
DT Book Review
C1 [Mayer, Chris] US Mil Acad, Dept English & Philosophy, West Point, NY 10996 USA.
RP Mayer, C (reprint author), US Mil Acad, Dept English & Philosophy, West Point, NY 10996 USA.
EM christopher.mayer@usma.edu
NR 1
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0022-5363
EI 1573-0492
J9 J VALUE INQUIRY
JI J. Value Inq.
PD SEP
PY 2015
VL 49
IS 3
BP 491
EP 495
DI 10.1007/s10790-014-9417-1
PG 5
WC Ethics; Philosophy
SC Social Sciences - Other Topics; Philosophy
GA CN1ZQ
UT WOS:000358220200012
ER
PT J
AU Rupper, G
Rudin, S
Shur, M
AF Rupper, Greg
Rudin, Sergey
Shur, Michael
TI Response of plasmonic terahertz detectors to amplitude modulated signals
SO SOLID-STATE ELECTRONICS
LA English
DT Article
DE Terahertz detectors; Semiconductor transistor; Plasmonic regime
AB We present theoretical study of the response of two-dimensional gated electron gas to an amplitude modulated signals with carrier frequency in the terahertz range. The model is based on complete hydrodynamic equations, and includes effects of viscosity, pressure gradients and thermal transport in the conduction channel of a high electron mobility semiconductor transistor (HEMT). The modulation response was evaluated as a function of modulation frequency f(M) for a wide range of mobility values. Maximum modulation frequency f(MAX) was evaluated as a function of channel mobility, with typical values of f(MAX) in the subterahertz range of frequencies. Our analysis shows that short channel field effect transistors operating in the plasmonic regime can meet all the requirements for applications as terahertz detectors and modulators in ultra high-speed wireless communication circuits. Published by Elsevier Ltd.
C1 [Rupper, Greg; Rudin, Sergey] US Army Res Lab, Adelphi, MD 20783 USA.
[Shur, Michael] Rensselaer Polytech Inst, Troy, NY 12180 USA.
RP Rudin, S (reprint author), US Army Res Lab, Adelphi, MD 20783 USA.
EM sergey.i.rudin.civ@mail.mil
RI Shur, Michael/A-4374-2016
OI Shur, Michael/0000-0003-0976-6232
FU U.S. Army Research Laboratory through the Collaborative Research
Alliance (CRA) for Multi-Scale Modeling of Electronic materials (MSME)
FX The work at RPI (M. Shur) was supported in part by the U.S. Army
Research Laboratory through the Collaborative Research Alliance (CRA)
for Multi-Scale Modeling of Electronic materials (MSME).
NR 19
TC 1
Z9 1
U1 3
U2 15
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0038-1101
EI 1879-2405
J9 SOLID STATE ELECTRON
JI Solid-State Electron.
PD SEP
PY 2015
VL 111
BP 76
EP 79
DI 10.1016/j.sse.2015.05.035
PG 4
WC Engineering, Electrical & Electronic; Physics, Applied; Physics,
Condensed Matter
SC Engineering; Physics
GA CN3AD
UT WOS:000358294500014
ER
PT J
AU Katoski, SE
Meyer, H
Ibrahim, S
AF Katoski, Sarah E.
Meyer, Hermann
Ibrahim, Sofi
TI An approach for identification of unknown viruses using
sequencing-by-hybridization
SO JOURNAL OF MEDICAL VIROLOGY
LA English
DT Article
DE ebola; microarray; sequencing-by-hybridization; virus; high-throughput
sequencing
ID POLYMERASE-CHAIN-REACTION; NUCLEASE PCR; DNA; FILOVIRUSES; DIAGNOSIS;
GENOME; ASSAY
AB Accurate identification of biological threat agents, especially RNA viruses, in clinical or environmental samples can be challenging because the concentration of viral genomic material in a given sample is usually low, viral genomic RNA is liable to degradation, and RNA viruses are extremely diverse. A two-tiered approach was used for initial identification, then full genomic characterization of 199 RNA viruses belonging to virus families Arenaviridae, Bunyaviridae, Filoviridae, Flaviviridae, and Togaviridae. A Sequencing-by-hybridization (SBH) microarray was used to tentatively identify a viral pathogen then, the identity is confirmed by guided next-generation sequencing (NGS). After optimization and evaluation of the SBH and NGS methodologies with various virus species and strains, the approach was used to test the ability to identify viruses in blinded samples. The SBH correctly identified two Ebola viruses in the blinded samples within 24hr, and by using guided amplicon sequencing with 454 GS FLX, the identities of the viruses in both samples were confirmed. SBH provides at relatively low-cost screening of biological samples against a panel of viral pathogens that can be custom-designed on a microarray. Once the identity of virus is deduced from the highest hybridization signal on the SBH microarray, guided (amplicon) NGS sequencing can be used not only to confirm the identity of the virus but also to provide further information about the strain or isolate, including a potential genetic manipulation. This approach can be useful in situations where natural or deliberate biological threat incidents might occur and a rapid response is required. J. Med. Virol. 87:1616-1624, 2015. (c) 2015 Wiley Periodicals, Inc.
C1 [Katoski, Sarah E.; Ibrahim, Sofi] US Army Res Dev & Engn Command, Edgewood Chem Biol Ctr, Aberdeen Proving Ground, MD 21010 USA.
[Katoski, Sarah E.] Leidos, Gunpowder Branch, Aberdeen Proving Ground, MD USA.
[Meyer, Hermann] Bundeswehr Inst Microbiol, Div Virol, Munich, Germany.
RP Ibrahim, S (reprint author), US Army Res Dev & Engn Command, Edgewood Chem Biol Ctr, 5183 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 USA.
EM sofi.ibrahim@us.army.mil
FU Defense Threat Reduction Agency
FX We thank Aisha Hajjaj, Mohamed Aitichou, and Jason Farlow for their
excellent technical support during the development and testing of the
protocols used in this work. We thank Dr. Jose-Luis Sagripanti for his
valuable comments and review of the manuscript. This research was
supported by the Defense Threat Reduction Agency. The mention of
materials or products in this article does not constitute endorsement by
the Department of Defense or the US Government.
NR 20
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U1 0
U2 24
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0146-6615
EI 1096-9071
J9 J MED VIROL
JI J. Med. Virol.
PD SEP
PY 2015
VL 87
IS 9
BP 1616
EP 1624
DI 10.1002/jmv.24196
PG 9
WC Virology
SC Virology
GA CM8JC
UT WOS:000357944900024
PM 25976068
ER
PT J
AU Zander, NE
Piehler, T
Boggs, ME
Banton, R
Benjamin, R
AF Zander, Nicole E.
Piehler, Thuvan
Boggs, Mary E.
Banton, Rohan
Benjamin, Richard
TI In vitro studies of primary explosive blast loading on neurons
SO JOURNAL OF NEUROSCIENCE RESEARCH
LA English
DT Article
DE primary blast; traumatic brain injury; in vitro model; dissociated
cultures; explosives
ID TRAUMATIC BRAIN-INJURY; NERVE GROWTH-FACTOR; PHEOCHROMOCYTOMA CELLS;
INDUCED NEUROTRAUMA; OXIDATIVE STRESS; MODEL; DAMAGE; DYSFUNCTION;
RECOVERY; CULTURES
AB In a military setting, traumatic brain injury (TBI) is frequently caused by blast waves that can trigger a series of neuronal biochemical changes. Although many animal models have been used to study the effects of primary blast waves, elucidating the mechanisms of damage in a whole-animal model is extremely complex. In vitro models of primary blast, which allow for the deconvolution of mechanisms, are relatively scarce. It is largely unknown how structural damage at the cellular level impacts the functional activity at variable time scales after the TBI event. A novel in vitro system was developed to probe the effects of explosive blast (ranging from approximate to 25 to 40 psi) on dissociated neurons. PC12 neurons were cultured on laminin-coated substrates, submerged underwater, and subjected to single and multiple blasts in a controlled environment. Changes in cell membrane permeability, viability, and cell morphology were evaluated. Significant increases in axonal beading were observed in the injured cells. In addition, although cell death was minimal after a single insult, cell viability decreased significantly following repeated blast exposure. (c) 2015 Wiley Periodicals, Inc.
C1 [Zander, Nicole E.; Piehler, Thuvan; Banton, Rohan; Benjamin, Richard] US Army Res Lab, Weap & Mat Res Directorate, Aberdeen Proving Ground, MD USA.
[Boggs, Mary E.] Univ Delaware, Dept Biol, Newark, DE USA.
RP Zander, NE (reprint author), US Army Res Lab, Dept Army, RDRL WMM G, Bldg 4600, Aberdeen, MD 21005 USA.
EM nicole.e.zander.civ@mail.mil
FU United States Army Research Laboratory's Director's Science Initiative
FX Contract grant sponsor: United States Army Research Laboratory's
Director's Science Initiative.
NR 42
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U1 2
U2 13
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0360-4012
EI 1097-4547
J9 J NEUROSCI RES
JI J. Neurosci. Res.
PD SEP
PY 2015
VL 93
IS 9
BP 1353
EP 1363
DI 10.1002/jnr.23594
PG 11
WC Neurosciences
SC Neurosciences & Neurology
GA CM9HP
UT WOS:000358019100005
PM 25914380
ER
PT J
AU Poordad, F
Rustgi, V
Brown, RS
Patel, V
Kugelmas, M
Regenstein, F
Balart, L
LaBrecque, D
Brown, K
Avila, M
Biederman, M
Freed, G
Smith, R
Bernstein, M
Arnold, H
Cahan, J
Fink, S
Katkov, W
Massoumi, H
Harrison, S
AF Poordad, Fred
Rustgi, Vinod
Brown, Robert S., Jr.
Patel, Vishal
Kugelmas, Marcelo
Regenstein, Fredric
Balart, Luis
LaBrecque, Douglas
Brown, Kimberly
Avila, Mark
Biederman, Michael
Freed, Glenn
Smith, Richard
Bernstein, Marc
Arnold, Hays
Cahan, Joel
Fink, Scott
Katkov, William
Massoumi, Hatef
Harrison, Stephen
TI The impact of an educational program on HCV patient outcomes using
boceprevir in community practices (OPTIMAL trial)
SO THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
LA English
DT Article
DE boceprevir; genotype 1; hepatitis C virus; naive; partial responder;
relapser
ID GENOTYPE 1 INFECTION; C VIRUS-INFECTION; MEDICAL-EDUCATION; TELAPREVIR;
CARE
AB Objectives: Although effective, direct acting antiviral (DAA) therapies for genotype 1 (GT 1) hepatitis C virus (HCV) have been associated with compliance challenges. Additionally, treatment at predominantly community-based centers has been associated with low retention of patients on treatment and higher dropout rates. The OPTIMAL Phase IV interventional trial (ClinicalTrials.gov Identifier: NCT01405027) was designed to evaluate the impact of an education program for community investigator (CI) sites participating in a Chronic Liver Disease Foundation study treating chronic GT 1 HCV patients.
Methods: This physician educational program was administered by 22 Hepatology Centers of Educational Expertise (HCEE) academic sites to 33 CI sites asked to participate from December 2011 to July 2012. The HCEE mentors from DAA-experienced academic sites educated those at CI sites on therapeutic management, practice, and patient outcomes through a series of four standardized educational sequence visits regarding the use of first generation HCV protease inhibitors and the overall treatment of HCV.
Results: Treatment duration compliance rates for patients treated at CI sites versus those treated at HCEE academic sites were evaluable in 77 of 84 HCEE academic site patients, 102 of 113 patients treated at CI sites, and 179 of 197 overall patients. The treatment duration compliance rates for patients treated at HCEE academic sites, CI sites and overall were 85.4 25.39%, 83.8 +/- 27.37%, and 84.5 +/- 26.48%, respectively, and did not differ statistically between the groups (p = 0.49). Almost half (47%) of the patients in the study achieved a sustained virological response for 24 weeks (SVR24) regardless of the type of site (p = 0.64). Safety profiles were similar at both HCEE and CI sites.
Conclusions: These results demonstrated that education of CI sites unfamiliar with DAAs resulted in patient outcomes consistent with those observed at DAA-experienced academic sites.
C1 [Poordad, Fred] Univ Texas Hlth Sci Ctr San Antonio, Texas Liver Inst, San Antonio, TX 78215 USA.
[Rustgi, Vinod] Metropolitan Res, Fairfax, VA USA.
[Brown, Robert S., Jr.] Weill Cornell Med Coll, New York, NY USA.
[Patel, Vishal] Temple Univ, Sch Med, Philadelphia, PA USA.
[Kugelmas, Marcelo] South Denver Gastroenterol, Englewood, CO USA.
[Regenstein, Fredric] St Lukes Hosp, Kansas City, MO USA.
[Balart, Luis] Tulane Univ, Sch Med, New Orleans, LA 70112 USA.
[LaBrecque, Douglas] Univ Iowa, Sch Med, Iowa City, IA 52242 USA.
[Brown, Kimberly] Henry Ford Hosp, Detroit, MI 48202 USA.
[Avila, Mark] Digest Med Associates, Hialeah, FL USA.
[Biederman, Michael] South Oakland Gastroenterol Associates, Farmington, MI USA.
[Freed, Glenn] Private Practice, Pottsville, PA USA.
[Smith, Richard] Flint Gastroenterol Associates, Grand Blanc, MI USA.
[Bernstein, Marc] Mercy Clin Hepatol, St Louis, MO USA.
[Arnold, Hays] Gastroenterol Consultants San Antonio, San Antonio, TX USA.
[Cahan, Joel] Consultants Gastroenterol, Munster, IN USA.
[Fink, Scott] Main Line Gastroenterol Associates, Wynnewood, PA USA.
[Katkov, William] St Johns Hlth Ctr, Santa Monica, CA USA.
[Massoumi, Hatef] New York Associates Gastroenterol, Bronx, NY USA.
[Harrison, Stephen] Brooke Army Med Ctr, Ft Sam Houston, TX 78234 USA.
RP Poordad, F (reprint author), Univ Texas Hlth Sci Ctr San Antonio, Texas Liver Inst, 607 Camden St,Suite 101, San Antonio, TX 78215 USA.
EM poordad@uthscsa.edu
FU Chronic Liver Disease Foundation through from Merck & Co., Kenilworth,
NJ, USA
FX This work was supported by the Chronic Liver Disease Foundation through
an investigator initiated study grant from Merck & Co., Kenilworth, NJ,
USA. The work is a product of the authors alone with no involvement of
the sponsor.
NR 13
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U1 0
U2 7
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1756-283X
EI 1756-2848
J9 THER ADV GASTROENTER
JI Ther. Adv. Gastroenterol.
PD SEP
PY 2015
VL 8
IS 5
BP 263
EP 269
DI 10.1177/1756283X15588876
PG 7
WC Gastroenterology & Hepatology
SC Gastroenterology & Hepatology
GA CM8DL
UT WOS:000357926800003
PM 26327916
ER
PT J
AU Poudel, A
Shrestha, SS
Sandhu, JS
Chu, TP
Pergantis, CG
AF Poudel, Anish
Shrestha, Shashi Shekhar
Sandhu, Jaswinder Singh
Chu, Tsuchin Philip
Pergantis, Charles George
TI Comparison and analysis of Acoustography with other NDE techniques for
foreign object inclusion detection in graphite epoxy composites
SO COMPOSITES PART B-ENGINEERING
LA English
DT Article
DE Carbon fibre; Laminates; Defects; Non-destructive evaluation
ID INFRARED THERMOGRAPHY; ULTRASONIC INSPECTION; ENHANCEMENT
AB This paper presents the use of a novel through-transmission ultrasonic (TTU) Acoustography non-destructive evaluation (NDE) method to detect foreign object inclusion (FOI) defects in graphite epoxy composite laminates. The study employed three different composite test standards with varied size FOI defects embedded at varying depth within the composite laminates. For validation, Acoustography results were directly compared with conventional immersion TTU testing and infrared thermography (IRT) methods. From results obtained, it was demonstrated that the Signal-to-Noise Ratio (SNR) measurements for Acoustography were more than 6:1 and were in good correlation with immersion TTU and IRT results. The defect sizing ability of TTU Acoustography for FOI defects in graphite epoxy composite laminates were also in strong correlation with immersion TTU and IRT techniques. Finally, for the three laboratory systems employed in this study, typical panel TTU Acoustography inspection time was just about three minutes to scan a 300 mm x 300 mm (11.8 '' x 11.8 '') area, which was more than three times faster compared to IRT and sixty times faster to conventional immersion TTU C-Scan techniques. This is a very significant finding for the reason that Acoustography is being developed as a faster, more efficient, and affordable alternative to traditional ultrasonic inspection systems for composite manufacturing quality control and quality assurance (QC/QA) and field maintenance of composite structure applications. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Poudel, Anish; Shrestha, Shashi Shekhar; Chu, Tsuchin Philip] So Illinois Univ, Dept Mech Engn & Energy Proc, Carbondale, IL 62901 USA.
[Sandhu, Jaswinder Singh] Santec Syst Inc, Arlington Hts, IL 60005 USA.
[Pergantis, Charles George] US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RP Poudel, A (reprint author), So Illinois Univ, Dept Mech Engn & Energy Proc, 1230 Lincoln Dr,Mail Code 6603, Carbondale, IL 62901 USA.
EM anish@siu.edu; j-sandhu@santecsystems.com;
charles.g.pergantis.civ@mail.mil
NR 33
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U1 1
U2 9
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1359-8368
EI 1879-1069
J9 COMPOS PART B-ENG
JI Compos. Pt. B-Eng.
PD SEP 1
PY 2015
VL 78
BP 86
EP 94
DI 10.1016/j.compositesb.2015.03.048
PG 9
WC Engineering, Multidisciplinary; Materials Science, Composites
SC Engineering; Materials Science
GA CL5GO
UT WOS:000356988000009
ER
PT J
AU Allison, PG
Weiss, CA
Moser, RD
Diaz, AJ
Rivera, OG
Holton, SS
AF Allison, P. G.
Weiss, C. A., Jr.
Moser, R. D.
Diaz, A. J.
Rivera, O. G.
Holton, S. S.
TI Nanoindentation and SEM/EDX characterization of the geopolymer-to-steel
interfacial transition zone for a reactive porcelain enamel coating
SO COMPOSITES PART B-ENGINEERING
LA English
DT Article
DE Geopolymer; Interface/interphase; Mechanical properties; Chemical
analysis; Electron microscopy
ID MECHANICAL-PROPERTIES; SURFACE-ROUGHNESS; CONCRETE
AB The increasing use of alternative cementitious materials such as geopolymers as an environmentally-friendly alternative to traditional cements requires an improved understanding of the interfacial transition zone (ITZ) between the matrix and reinforcing steels. In this study, nanoindentation measurements were spatially coupled to images with scanning electron microscopy and chemical composition using energy dispersive X-ray microanalysis. The study focused on the microstructure and chemical composition of the interfacial transition zone (ITZ) for reinforcing steel embedded in a geopolymer mortar. The ITZ was analyzed for uncoated steel and steel coated with a reactive porcelain enamel that improves bonding and corrosion resistance. Results indicate that a more gradual transition of mechanical properties and chemical composition for the coated steel coupled with improved integration to the mortar correlates to increased bond strength measured in macroscale experiments. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Allison, P. G.; Rivera, O. G.] Univ Alabama, Dept Mech Engn, Tuscaloosa, AL 35406 USA.
[Weiss, C. A., Jr.; Moser, R. D.; Holton, S. S.] US Army Engineer Res & Dev Ctr, Geotech & Struct Lab, Vicksburg, MS 39180 USA.
[Diaz, A. J.] Univ Puerto Rico, Dept Mech Engn, Mayaguez, PR 00680 USA.
RP Allison, PG (reprint author), Univ Alabama, Dept Mech Engn, Tuscaloosa, AL 35406 USA.
EM pallison@ua.edu
NR 31
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U1 9
U2 41
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1359-8368
EI 1879-1069
J9 COMPOS PART B-ENG
JI Compos. Pt. B-Eng.
PD SEP 1
PY 2015
VL 78
BP 131
EP 137
DI 10.1016/j.compositesb.2015.03.011
PG 7
WC Engineering, Multidisciplinary; Materials Science, Composites
SC Engineering; Materials Science
GA CL5GO
UT WOS:000356988000013
ER
PT J
AU Barreda, AI
Sanz, JM
de la Osa, RA
Saiz, JM
Moreno, F
Gonzalez, F
Videen, G
AF Barreda, Angela I.
Sanz, Juan M.
Alcaraz de la Osa, Rodrigo
Saiz, Jose M.
Moreno, Fernando
Gonzalez, Francisco
Videen, Gorden
TI Using linear polarization to monitor nanoparticle purity
SO JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER
LA English
DT Article
DE Nanoparticles; Polarization; Resonances; MDR
ID LIGHT-SCATTERING RESONANCES; OPTICAL-PROPERTIES; SILICON NANOPARTICLES;
MAGNETIC-PROPERTIES; SMALL PARTICLES; SPHERES; SHAPE
AB We study the effect of contaminants on the resonances of silicon nanoparticles (NPs) by considering the spectral evolution of the degree of linear polarization of light scattered at right angles to the incident beam, P-L(90 degrees). From an optical point of view, a decrease in the purity of silicon nanoparticles due to the presence of contaminants impacts the NP effective refractive index. We analyze this effect for a silicon nanosphere (R=200 nm) suspended in different media. We focus on the spectral range where the quadrupolar magnetic, dipolar electric and dipolar magnetic resonances appear. The weakness of the resonances induced on the P-L(90 degrees) spectrum by the lack of purity can be used to quantify the contamination of the material. In addition, it is shown that Kerker conditions also suffer from a spectral shift, that is quantified as a function of material purity. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Barreda, Angela I.; Sanz, Juan M.; Alcaraz de la Osa, Rodrigo; Saiz, Jose M.; Moreno, Fernando; Gonzalez, Francisco; Videen, Gorden] Univ Cantabria, Dept Fis Aplicada, Grp Opt, Fac Ciencias, E-39005 Santander, Spain.
[Videen, Gorden] Inst Nacl Tecn Aeroespacial, Madrid 28850, Spain.
[Videen, Gorden] Army Res Lab, AMSRL CI EM, Adelphi, MD 20783 USA.
RP Gonzalez, F (reprint author), Univ Cantabria, Dept Fis Aplicada, Grp Opt, Fac Ciencias, Avda Los Castros S-N, E-39005 Santander, Spain.
EM gonzaleff@unican.es
RI Sanz, Juan/L-7922-2014
OI Sanz, Juan/0000-0002-2024-9909
FU MICINN (Spanish Ministry of Science and Innovation) [FIS2013-45854-P];
USAITC-A (United States Army International Technology Center Atlantic)
[W911NF-13-1-0245]
FX This research was supported by MICINN (Spanish Ministry of Science and
Innovation, project FIS2013-45854-P) and USAITC-A (United States Army
International Technology Center Atlantic, grant W911NF-13-1-0245).
NR 29
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U1 3
U2 5
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-4073
EI 1879-1352
J9 J QUANT SPECTROSC RA
JI J. Quant. Spectrosc. Radiat. Transf.
PD SEP
PY 2015
VL 162
SI SI
BP 190
EP 196
DI 10.1016/j.jqsrt.2015.03.005
PG 7
WC Optics; Spectroscopy
SC Optics; Spectroscopy
GA CM2WU
UT WOS:000357543800020
ER
PT J
AU Sviatenko, LK
Gorb, L
Hill, FC
Leszczynska, D
Okovytyy, SI
Leszczynski, J
AF Sviatenko, Liudmyla K.
Gorb, Leonid
Hill, Frances C.
Leszczynska, Danuta
Okovytyy, Sergiy I.
Leszczynski, Jerzy
TI Alkaline hydrolysis of hexahydro-1,3,5-trinitro-1,3,5-triazine: M06-2X
investigation
SO CHEMOSPHERE
LA English
DT Article
DE Hexahydro-1,3,5-trinitro-1,3,5-triazine; 4-Nitro-2,4-diazabutanal;
Mechanism; UV-VIS spectra
ID DENSITY FUNCTIONALS; AQUEOUS-SOLUTION; EXPLOSIVES RDX; RHODOCOCCUS SP;
AB-INITIO; HMX; TNT; BIODEGRADATION; KINETICS; WATER
AB Alkaline hydrolysis mechanism of possible environmental contaminant RDX (hexahydro-1,3,5-trinitro-1,3,5-triazine) was investigated computationally at the PCM(Pauling)/M06-2X/6-311++G(d,p) level of theory. Results obtained show that the initial deprotonation of RDX by hydroxide leads to nitrite elimination and formation of a denitrated cyclohexene intermediate. Further nucleophilic attack by hydroxide onto cyclic C=N double bond results in ring opening. It was shown that the presence of hydroxide is crucial for this stage of the reaction. The dominant decomposition pathway leading to a ring-opened intermediate was found to be formation of 4-nitro-2,4-diazabutanal. Hydrolytic transformation of its byproduct (methylene nitramine) leads to end products such as formaldehyde and nitrous oxide. Computational results are in a good agreement with experimental data on hydrolysis of RDX, suggesting that 4-nitro-2,4-diazabutanal, nitrite, formaldehyde, and nitrous oxide are main products for early stages of RDX decomposition under alkaline conditions. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Sviatenko, Liudmyla K.; Leszczynski, Jerzy] Jackson State Univ, Dept Chem & Biochem, Interdisciplinary Ctr Nanotox, Jackson, MS 39217 USA.
[Sviatenko, Liudmyla K.; Okovytyy, Sergiy I.] Oles Honchar Dnipropetrovsk Natl Univ, Dept Organ Chem, UA-49000 Dnepropetrovsk, Ukraine.
[Gorb, Leonid] HX5 LLC, Vicksburg, MS 39180 USA.
[Hill, Frances C.] US Army, Erdc, Vicksburg, MS 39180 USA.
[Leszczynska, Danuta] Jackson State Univ, Dept Civil & Environm Engn, Interdisciplinary Ctr Nanotox, Jackson, MS 39217 USA.
RP Leszczynski, J (reprint author), Jackson State Univ, Dept Chem & Biochem, Interdisciplinary Ctr Nanotox, 1325 JR Lynch St,POB 17910, Jackson, MS 39217 USA.
EM jerzy@icnanotox.org
RI Okovytyy, Sergiy/F-9838-2010
OI Okovytyy, Sergiy/0000-0003-4367-1309
FU Environmental Quality Technology Program of the United States Army Corps
of Engineers by the USAERDC; Engineer Research and Development Center
(ERDC) [W912HZ-13-P-0037]; Extreme Science and Engineering Discovery
Environment (XSEDE) by National Science Foundation [OCI-1053575]; XSEDE
[DMR110088]
FX The use of trade, product, or firm names in this report is for
descriptive purposes only and does not imply endorsement by the U.S.
Government. Results in this study were funded and obtained from research
conducted under the Environmental Quality Technology Program of the
United States Army Corps of Engineers by the USAERDC. Permission was
granted by the Chief of Engineers to publish this information. The
findings of this report are not to be construed as an official
Department of the Army position unless so designated by other authorized
documents. We thank Engineer Research and Development Center (ERDC) for
financial support (Grant No. is W912HZ-13-P-0037). The computation time
was provided by the Extreme Science and Engineering Discovery
Environment (XSEDE) by National Science Foundation Grant No. OCI-1053575
and XSEDE award allocation Number DMR110088 and by the Mississippi
Center for Supercomputer Research.
NR 40
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U1 2
U2 18
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0045-6535
EI 1879-1298
J9 CHEMOSPHERE
JI Chemosphere
PD SEP
PY 2015
VL 134
BP 31
EP 38
DI 10.1016/j.chemosphere.2015.03.064
PG 8
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA CK9GV
UT WOS:000356549500005
PM 25911044
ER
PT J
AU Taylor, S
Dontsova, K
Walsh, ME
Walsh, MR
AF Taylor, Susan
Dontsova, Katerina
Walsh, Marianne E.
Walsh, Michael R.
TI Outdoor dissolution of detonation residues of three insensitive
munitions (IM) formulations
SO CHEMOSPHERE
LA English
DT Article
DE Insensitive muntions (IM); Particle size distributions; Outdoor
dissolution; Particle life spans
ID COMPOUND 2,4-DINITROANISOLE; NTO; NITROGUANIDINE; PERCHLORATE; DNAN;
TNT; RDX; HMX
AB We seek to understand the environmental fate of three new insensitive munitions, explosive formulations developed to reduce the incidence of unintended detonations. To this end, we measured the size distribution of residues from low order detonations of IMX 101, IMX 104, and PAX 21-filled munitions and are studying how these three formulations weather and dissolve outdoors. The largest pieces collected from the detonations were centimeter-sized and we studied 12 of these in the outdoors test. We found that the particles break easily and that the dissolution of 2,4-dinitroanisole (DNAN) is quasi-linear as a function of water volume. DNAN is the matrix and the least soluble major constituent of the three formulations. We used DNAN's linear dissolution rate to estimate the life span of the pieces. Particles ranging in mass from 0.3 to 3.5 g will completely dissolve in 3-21 years given 100 cm y(-1) precipitation rates. Published by Elsevier Ltd.
C1 [Taylor, Susan; Walsh, Marianne E.; Walsh, Michael R.] US Army, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA.
[Dontsova, Katerina] Univ Arizona, Tucson, AZ 85721 USA.
RP Taylor, S (reprint author), US Army, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA.
EM Susan.Taylor@erdc.dren.mil
FU Strategic Environmental Remediation Development Program [ER-2200,
ER-2219]
FX We thank Nancy Perron and Matthew Bigl for laboratory support. We thank
Matt Brian at National Technical Systems for the detonation residues of
IMX 101 and Kelsey Gagnon for measuring their size distributions. The
Strategic Environmental Remediation Development Program funded this work
under projects ER-2200 and ER-2219 and we thank Dr. Andrea Leeson, our
program manager, for her support.
NR 30
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U1 3
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PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0045-6535
EI 1879-1298
J9 CHEMOSPHERE
JI Chemosphere
PD SEP
PY 2015
VL 134
BP 250
EP 256
DI 10.1016/j.chemosphere.2015.04.041
PG 7
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA CK9GV
UT WOS:000356549500034
PM 25966455
ER
PT J
AU Darling, KA
Tschopp, MA
Liu, ZK
AF Darling, Kris A.
Tschopp, Mark A.
Liu, Zi-Kui
TI Rebuttal comments on "Mitigating grain growth in binary nanocrystalline
alloys through solute selection based on thermodynamic stability maps''
SO COMPUTATIONAL MATERIALS SCIENCE
LA English
DT Editorial Material
DE Thermodynamic stability; Nanocrystalline metals
ID BOUNDARY SEGREGATION; DESIGN; SIZE
AB Darling et al. (2014) outlined a new model for nanocrystalline stability and applied it to a large number of systems to demonstrate its utility/applicability and how to visualize/select promising solutes in these nanocrystalline systems. The present article addresses some of the concerns raised by Lejcek and Hofmann (2015) and those that additional readers may have about this work. In some cases we have found that their concerns reflect ones that are shared by the community in developing and applying these sorts of models. For instance, in utilizing thermodynamic properties from such a large database of systems, researchers should use due diligence in extrapolating results to real systems - this model should be used as a guide for selecting prospective binary systems that may exhibit some degree of thermodynamic stability in nanocrystalline materials. Last, there was an oversight in terms of the phase transformation temperature for Fe and Ti, which negligibly changed the model results. In short, the present article is intended to bring to light and clarify some of the items raised by Lejcek and Hofmann. Published by Elsevier B.V.
C1 [Darling, Kris A.; Tschopp, Mark A.] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA.
[Liu, Zi-Kui] Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA.
RP Darling, KA (reprint author), US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RI Liu, Zi-Kui/A-8196-2009;
OI Liu, Zi-Kui/0000-0003-3346-3696; Tschopp, Mark/0000-0001-8471-5035
NR 38
TC 0
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U1 3
U2 17
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0927-0256
EI 1879-0801
J9 COMP MATER SCI
JI Comput. Mater. Sci.
PD SEP
PY 2015
VL 107
BP 238
EP 242
DI 10.1016/j.commatsci.2015.04.052
PG 5
WC Materials Science, Multidisciplinary
SC Materials Science
GA CL4YQ
UT WOS:000356964900031
ER
PT J
AU Svensson, SP
Sarney, WL
Yu, KM
Ting, M
Calley, WL
Novikov, SV
Foxon, CT
Walukiewicz, W
AF Svensson, S. P.
Sarney, W. L.
Yu, K. M.
Ting, M.
Calley, W. L.
Novikov, S. V.
Foxon, C. T.
Walukiewicz, W.
TI Determination of N-/Ga-rich growth conditions, using in-situ auger
electron spectroscopy
SO JOURNAL OF CRYSTAL GROWTH
LA English
DT Article; Proceedings Paper
CT 18th International Conference on Molecular Beam Epitaxy (MBE 2014)
CY SEP 07-12, 2014
CL fLAGSTAFF, AZ
DE Characterization; Surface structure; Nitrides; Gallium compounds;
Semiconducting III-V materials; Semiconducting gallium compounds
ID MOLECULAR-BEAM EPITAXY; GA-RICH; SURFACE MORPHOLOGIES
AB In-situ Auger electron spectroscopy was used to determine the 1:1 flux ratios of Ga and N during growth of GaN by molecular beam epitaxy at low substrate temperatures. By linearly ramping the Ga-flux, while keeping the N-flux constant, and simultaneously measuring the chemical composition by monitoring N and Ga Auger peaks, the time of deviation from stoichiometry could be determined. The method was applied at very low substrate temperatures where reflection high-energy electron diffraction does not reveal clear growth mode changes. The importance of the N- vs Ga-rich conditions were confirmed with transmission electron microscopy which showed a distinct change in crystallinity between material at the top and bottom of the film, which are in agreement with previous findings. Published by Elsevier B.V.
C1 [Svensson, S. P.; Sarney, W. L.] US Army Res Lab, Adelphi, MD 20783 USA.
[Yu, K. M.; Ting, M.; Walukiewicz, W.] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Div Mat Sci, Berkeley, CA 94720 USA.
[Yu, K. M.] City Univ Hong Kong, Dept Phy & Mat Sci, Kowloon, Hong Kong, Peoples R China.
[Ting, M.] Univ Calif Berkeley, Dept Mech Engn, Berkeley, CA 94720 USA.
[Calley, W. L.] Staib Instruments Inc, Williamsburg, VA 23185 USA.
[Novikov, S. V.; Foxon, C. T.] Univ Nottingham, Sch Phys & Astron, Nottingham NG7 2RD, England.
RP Svensson, SP (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM stefan.p.svensson.civ@mail.mil
OI Yu, Kin Man/0000-0003-1350-9642
NR 16
TC 1
Z9 1
U1 0
U2 13
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0022-0248
EI 1873-5002
J9 J CRYST GROWTH
JI J. Cryst. Growth
PD SEP 1
PY 2015
VL 425
BP 2
EP 4
DI 10.1016/j.jcrysgro.2015.02.035
PG 3
WC Crystallography; Materials Science, Multidisciplinary; Physics, Applied
SC Crystallography; Materials Science; Physics
GA CL0YO
UT WOS:000356669200002
ER
PT J
AU Svensson, SP
Sarney, WL
Connelly, BC
Anderson, EM
Millunchick, JM
AF Svensson, S. P.
Sarney, W. L.
Connelly, B. C.
Anderson, E. M.
Millunchick, J. M.
TI Growth temperature and surfactant effects on the properties of mixed
group V alloys
SO JOURNAL OF CRYSTAL GROWTH
LA English
DT Article; Proceedings Paper
CT 18th International Conference on Molecular Beam Epitaxy (MBE 2014)
CY SEP 07-12, 2014
CL fLAGSTAFF, AZ
DE molecular beam epitaxy; Semiconducting III-V materials
AB The optical properties of InAsSb, nominally lattice marched to GaSb, grown at varying substrate temperatures with and without Bi-surfactant exposure, were studied with photoluminescence (PL). Both Bi exposure and increasing substrate temperatures reduce the Sb-incorporation and produce strained layers. The bandgap of lattice mismatched layers grown in this way is lowered compared to unstrained material. The PL intensity decreases dramatically when the lattice mismatch increases. The PL intensity also shows significant broadening that can be interpreted as evidence for inhomogeneous alloy distributions induced by the Bi. Published by Elsevier EN.
C1 [Svensson, S. P.; Sarney, W. L.; Connelly, B. C.] US Army Res Lab, Adelphi, MD 20783 USA.
[Anderson, E. M.; Millunchick, J. M.] Univ Michigan, Dept Mat Sci & Engn, Ann Arbor, MI 48109 USA.
RP Svensson, SP (reprint author), US Army Res Lab, Adelphi, MD 20783 USA.
EM stefan.p.svensson.civ@mail.mil
FU Department of Defense, Army Research Office [W911NF-12-1-0338]
FX EMA and JMM gratefully acknowledge Chakrapani Varanasi and the support
of the Department of Defense, Army Research Office via the grant number
W911NF-12-1-0338.
NR 10
TC 0
Z9 0
U1 5
U2 18
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0022-0248
EI 1873-5002
J9 J CRYST GROWTH
JI J. Cryst. Growth
PD SEP 1
PY 2015
VL 425
BP 234
EP 236
DI 10.1016/j.jcrysgro.2015.02.082
PG 3
WC Crystallography; Materials Science, Multidisciplinary; Physics, Applied
SC Crystallography; Materials Science; Physics
GA CL0YO
UT WOS:000356669200054
ER
PT J
AU Sarney, WL
Svensson, SP
Novikov, SV
Yu, KM
Walukiewicz, W
Ting, M
Foxon, CT
AF Sarney, W. L.
Svensson, S. P.
Novikov, S. V.
Yu, K. M.
Walukiewicz, W.
Ting, M.
Foxon, C. T.
TI Exploration of the growth parameter space for MBE-grown GaN1-xSbx highly
mismatched alloys
SO JOURNAL OF CRYSTAL GROWTH
LA English
DT Article; Proceedings Paper
CT 18th International Conference on Molecular Beam Epitaxy (MBE 2014)
CY SEP 07-12, 2014
CL fLAGSTAFF, AZ
DE Crystal structure; Molecular beam epitaxy; Nitrides; Semiconducting
III-V materials
ID MOLECULAR-BEAM EPITAXY
AB Highly mismatched CaN1-xSbx alloys were grown under N-rich conditions at low substrate temperatures (325-550 degrees C) at a growth rates of similar to 0.09 mu m/hr on sapphire. The alloys ranged in Sb composition from 0% to 16%, with the bandgap shifting from 3.3 to 1.6 eV in accordance with the band anticrossing (BAC) model. We compare these results to growths from another chamber, having a different N source, and using a faster growth rate (similar to 0.24 mu m/hr), much lower substrate temperatures (as low as 80 degrees C), different III/V ratios and absolute fluxes. Despite the range of morphologies obtained, all alloys follow the predictions of the BAC model with the bandgap only depending on the Sb composition. Published by Elsevier BM.
C1 [Sarney, W. L.; Svensson, S. P.] US Army, Res Lab, Adelphi, MD 20783 USA.
[Novikov, S. V.; Foxon, C. T.] Univ Nottingham, Sch Phys & Astron, Nottingham NG7 2RD, England.
[Yu, K. M.; Walukiewicz, W.; Ting, M.] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Div Mat Sci, Berkeley, CA 94720 USA.
[Yu, K. M.] City Univ Hong Kong, Dept Phys & Mat Sci, Kowloon, Hong Kong, Peoples R China.
[Ting, M.] Univ Calif Berkeley, Dept Mech Engn, Berkeley, CA 94720 USA.
RP Sarney, WL (reprint author), US Army, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM wendy.l.sarney.civ@mail.mil
OI Yu, Kin Man/0000-0003-1350-9642
FU US. Department of Energy, Office of Science, Basic Energy Sciences,
Materials Sciences and Engineering Division [DE-AC02-05CH11231];
Engineering and Physical Sciences Research Council (EPSRC)
[EP/1004203/1]; U.S. Army Foreign Technology Assessment Support (HAS)
program [W911NF-12-2-0003]
FX RBS and optical measurements performed at LBNL were supported by the US.
Department of Energy, Office of Science, Basic Energy Sciences,
Materials Sciences and Engineering Division under Contract no.
DE-AC02-05CH11231. The MBE growth at the University of Nottingham was
undertaken with support from the Engineering and Physical Sciences
Research Council (EPSRC, Grant no, EP/1004203/1) and the U.S. Army
Foreign Technology Assessment Support (HAS) program (Grant no
W911NF-12-2-0003).
NR 8
TC 2
Z9 2
U1 0
U2 7
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0022-0248
EI 1873-5002
J9 J CRYST GROWTH
JI J. Cryst. Growth
PD SEP 1
PY 2015
VL 425
BP 255
EP 257
DI 10.1016/j.jcrysgro.2015.02.065
PG 3
WC Crystallography; Materials Science, Multidisciplinary; Physics, Applied
SC Crystallography; Materials Science; Physics
GA CL0YO
UT WOS:000356669200059
ER
PT J
AU Sarney, WL
Svensson, SP
Wang, D
Donetsky, D
Kipshidze, G
Shterengas, L
Lin, Y
Belenky, G
AF Sarney, W. L.
Svensson, S. P.
Wang, D.
Donetsky, D.
Kipshidze, G.
Shterengas, L.
Lin, Y.
Belenky, G.
TI AlInAsSb for M-LWIR detectors
SO JOURNAL OF CRYSTAL GROWTH
LA English
DT Article; Proceedings Paper
CT 18th International Conference on Molecular Beam Epitaxy (MBE 2014)
CY SEP 07-12, 2014
CL fLAGSTAFF, AZ
DE Crystal structure; Molecular beam epitaxy; Semiconducting III-V
materials
ID ALLOYS
AB Growth of unrelaxed and unstrained Al(z)ln(1-z)As(y)Sb(1-y) with a lattice constant=6.23 angstrom was demonstrated lnAs(1-x)Sb(x), with this lattice constant produces a bandgap corresponding to absorption in the long-wavelength infrared range. The structures were grown on GaSb substrates, using a lattice constant shifting buffer layer. Good photoluminescence intensity was shown, ranging from 2.0 to 4.5 mu m, demonstrating the potential for development of multi-color infrared detectors that can cover both the mid- and long-wavelength infrared bands. Published by Elsevier B.V.
C1 [Sarney, W. L.; Svensson, S. P.] US Army, Res Lab, Adelphi, MD 20783 USA.
[Wang, D.; Donetsky, D.; Kipshidze, G.; Shterengas, L.; Lin, Y.; Belenky, G.] SUNY Stony Brook, Dept Elect & Comp Engn, Stony Brook, NY 11794 USA.
RP Sarney, WL (reprint author), US Army, Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM wendy.l.sarney.civ@mail.mil
OI LIN, YOUXI/0000-0002-9092-2302
FU US Army Research Office [W911NF1220057]; US National Science Foundation
[DMR1160843]
FX Part of this work was supported by the US Army Research Office through
award W911NF1220057 and by the US National Science Foundation through
grant DMR1160843.
NR 15
TC 4
Z9 4
U1 5
U2 12
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0022-0248
EI 1873-5002
J9 J CRYST GROWTH
JI J. Cryst. Growth
PD SEP 1
PY 2015
VL 425
BP 357
EP 359
DI 10.1016/j.jcrysgro.2015.02.036
PG 3
WC Crystallography; Materials Science, Multidisciplinary; Physics, Applied
SC Crystallography; Materials Science; Physics
GA CL0YO
UT WOS:000356669200082
ER
PT J
AU Moser, A
Zimmermann, L
Dickerson, K
Grenell, A
Barr, R
Gerhardstein, P
AF Moser, Alecia
Zimmermann, Laura
Dickerson, Kelly
Grenell, Amanda
Barr, Rachel
Gerhardstein, Peter
TI They can interact, but can they learn? Toddlers' transfer learning from
touchscreens and television
SO JOURNAL OF EXPERIMENTAL CHILD PSYCHOLOGY
LA English
DT Article
DE Imitation; Transfer; Memory flexibility; Video deficit; Touchscreens;
Television; Social learning
ID AGE-RELATED-CHANGES; YOUNG CHILDRENS USE; INFANT MEMORY; TOUCH SCREEN;
2ND YEAR; IMITATION; EMULATION; OVERIMITATION; INFORMATION; PERSPECTIVE
AB Despite the ubiquity of touchscreen applications and television programs for young children, developmental research suggests that learning in this context is degraded relative to face-to-face interactions. Most previous research has been limited to transfer of learning from videos, making it difficult to isolate the relative perceptual and social influences for transfer difficulty, and has not examined whether the transfer deficit persists across early childhood when task complexity increases. The current study examined whether the transfer deficit persists in older children using a complex puzzle imitation task constructed to investigate transfer from video demonstrations. The current test adapted this task to permit bidirectional transfer from touchscreens as well. To test for bidirectional transfer deficits, 2.5- and 3-year-olds were shown how to assemble a three-piece puzzle on either a three-dimensional magnetic board or a two-dimensional touchscreen (Experiment 1). Unidirectional transfer from video was also tested (Experiment 2). Results indicate that a bidirectional transfer deficit persists through 3 years, with younger children showing a greater transfer deficit; despite high perceptual similarities and social engagement, children learned less in transfer tasks, supporting the memory flexibility account of the transfer deficit. Implications of these findings for use of screen media (e.g., video, tablets) in early education are discussed. (c) 2015 Elsevier Inc. All rights reserved.
C1 [Moser, Alecia; Gerhardstein, Peter] SUNY Binghamton, Dept Psychol, Binghamton, NY 13902 USA.
[Dickerson, Kelly] US Army Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD 21005 USA.
[Zimmermann, Laura; Grenell, Amanda; Barr, Rachel] Georgetown Univ, Dept Psychol, Washington, DC 20057 USA.
RP Gerhardstein, P (reprint author), SUNY Binghamton, Dept Psychol, Binghamton, NY 13902 USA.
EM gerhard@binghamton.edu
OI Barr, Rachel/0000-0002-5855-9718
FU National Science Foundation (NSF) [1023772]; Georgetown University
Graduate School of Arts and Sciences
FX This research was supported by a National Science Foundation (NSF) grant
to Peter Gerhardstein and Rachel Barr (1023772) and the Georgetown
University Graduate School of Arts and Sciences. The authors thank the
families for their participation and thank members of the Georgetown
Early Learning Project and the Binghamton Infant and Child Studies
Project, in particular James Tse, for developing software used in the
touchscreen manipulations, as well as Herietta Lee and Christine Cha,
for their help with data collection and coding.
NR 64
TC 9
Z9 9
U1 10
U2 49
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0022-0965
EI 1096-0457
J9 J EXP CHILD PSYCHOL
JI J. Exp. Child Psychol.
PD SEP
PY 2015
VL 137
BP 137
EP 155
DI 10.1016/j.jecp.2015.04.002
PG 19
WC Psychology, Developmental; Psychology, Experimental
SC Psychology
GA CK4NN
UT WOS:000356200600011
PM 25978678
ER
PT J
AU Urciuoli, D
Ryu, S
Capell, DC
Ibitayo, D
Koebke, G
Tipton, CW
AF Urciuoli, D.
Ryu, S.
Capell, D. C.
Ibitayo, D.
Koebke, G.
Tipton, C. W.
TI Performance of a 1-kV, Silicon Carbide Avalanche Breakdown Diode
SO IEEE TRANSACTIONS ON POWER ELECTRONICS
LA English
DT Article
DE Avalanche breakdown diode (ABD); silicon carbide (SiC); solid state
circuit breaker (SSCB); solid state power controller (SSPC); snubber;
metal oxide varistor (MOV); transient voltage suppression (TVS)
AB A SiC avalanche breakdown diode (ABD) having a nominal 1-kV breakdown voltage was fabricated to provide improved suppression of voltage transients induced during hard-switched turn-off of solid-state devices. Three SiC ABDs were pulsed 1000 times in an inductive load circuit at peak currents of over 100 A. Superior performance in peak pulse current, clamping voltage, and peak pulse power was seen, compared to the results of two series-connected commercial TVS devices, collectively having a comparable breakdown voltage. The transient thermal response of the SiC ABDs was calculated using a model for energy dissipation in short pulses. SiC ABD design parameters and test data were used to show that the reported performance of these devices was not related to package thermal impedance.
C1 [Urciuoli, D.; Ibitayo, D.; Koebke, G.; Tipton, C. W.] US Army Res Lab, Adelphi, MD 20783 USA.
[Ryu, S.; Capell, D. C.] Cree Inc, Durham, NC 27703 USA.
RP Urciuoli, D (reprint author), US Army Res Lab, Adelphi, MD 20783 USA.
EM damian.p.urciuoli.civ@mail.mil; sei-hyung_ryu@cree.com;
craig_capell@cree.com; oladimeji.o.ibitayo.civ@mail.mil;
mary.g.koebke.civ@mail.mil; charles.w.tipton6.civ@mail.mil
NR 10
TC 2
Z9 2
U1 1
U2 37
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 0885-8993
EI 1941-0107
J9 IEEE T POWER ELECTR
JI IEEE Trans. Power Electron.
PD SEP
PY 2015
VL 30
IS 9
BP 4643
EP 4645
DI 10.1109/TPEL.2015.2403199
PG 3
WC Engineering, Electrical & Electronic
SC Engineering
GA CG2UM
UT WOS:000353130800005
ER
PT J
AU Te, JA
Spradling-Reeves, KD
Dillman, JF
Wallqvist, A
AF Te, Jerez A.
Spradling-Reeves, Kimberly D.
Dillman, James F., III
Wallqvist, Anders
TI Neuroprotective mechanisms activated in non-seizing rats exposed to
sarin
SO BRAIN RESEARCH
LA English
DT Article
DE Sarin; Seizure; MAPK signaling pathway; Brain protection; Microarray
analysis; Whole-genome gene expression
ID SOLUBLE EPOXIDE HYDROLASE; SOMAN-INDUCED SEIZURES;
NECROSIS-FACTOR-ALPHA; MESSENGER-RNA; INDUCED APOPTOSIS; SIGNAL
PATHWAYS; NERVE AGENTS; PROTEIN; BRAIN; GENE
AB Exposure to organophosphate (OP) nerve agents, such as satin, may lead to uncontrolled seizures and irreversible brain injury and neuropathology. In rat studies, a median lethal dose of satin leads to approximately half of the animals developing seizures. Whereas previous studies analyzed transcriptomic effects associated with seizing satin-exposed rats, our study focused on the cohort of satin-exposed rats that did not develop seizures. We analyzed the genomic changes occurring in satin-exposed, non-seizing rats and compared differentially expressed genes and pathway activation to those of seizing rats. At the earliest time point (0.25 h) and in multiple satin-sensitive brain regions, defense response genes were commonly expressed in both groups of animals as compared to the control groups. All satin-exposed animals activated the MAPK signaling pathway, but only the seizing rats activated the apoptotic-associated JNK and p38 MAPK signaling sub-pathway. A unique phenotype of the non-seizing rats was the altered expression levels of genes that generally suppress inflammation or apoptosis. Importantly, the early transcriptional response for inflammation- and apoptosis-related genes in the thalamus showed opposite trends, with significantly down-regulated genes being up-regulated, and vice versa, between the seizing and non-seizing rats. These observations lend support to the hypothesis that regulation of anti-inflammatory genes might be part of an active and sufficient response in the non-seizing group to protect against the onset of seizures. As such, stimulating or activating these responses via pretreatment strategies could boost resilience against nerve agent exposures. Published by Elsevier B.V.
C1 [Te, Jerez A.; Wallqvist, Anders] US Army Med Res & Mat Command, Dept Def Biotechnol, High Performance Comp Software Applicat Inst, Telemed & Adv Technol Res Ctr, Ft Detrick, MD 21702 USA.
[Spradling-Reeves, Kimberly D.; Dillman, James F., III] US Army Med Res Inst Chem Def, Cell & Mol Biol Branch, Aberdeen Proving Ground, MD 21010 USA.
RP Wallqvist, A (reprint author), US Army Med Res & Mat Command, Dept Def Biotechnol, High Performance Comp Software Applicat Inst, Telemed & Adv Technol Res Ctr, ATTN MCMR TT,504 Scott St, Ft Detrick, MD 21702 USA.
EM sven.a.wallqvist.civ@mail.mil
OI wallqvist, anders/0000-0002-9775-7469
FU U.S. Army Medical Research and Materiel Command (Fort Detrick, MD) as
part of the U.S. Army's Network Science Initiative; Defense Threat
Reduction Agency [CBCall14-CBS-05-2-0007]
FX The authors were supported by the U.S. Army Medical Research and
Materiel Command (Fort Detrick, MD) as part of the U.S. Army's Network
Science Initiative, and by the Defense Threat Reduction Agency grant
CBCall14-CBS-05-2-0007. The opinions and assertions contained herein are
the private views of the authors and are not to be construed as official
or as reflecting the views of the U.S. Army or of the U.S. Department of
Defense. This paper has been approved for public release with unlimited
distribution.
NR 66
TC 2
Z9 2
U1 0
U2 12
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0006-8993
EI 1872-6240
J9 BRAIN RES
JI Brain Res.
PD AUG 27
PY 2015
VL 1618
BP 136
EP 148
DI 10.1016/j.brainres.2015.05.034
PG 13
WC Neurosciences
SC Neurosciences & Neurology
GA CP5XB
UT WOS:000359957600015
PM 26049129
ER
PT J
AU Jiang, RZ
Tran, DT
McClure, JP
Chu, D
AF Jiang, Rongzhong
Tran, Dat T.
McClure, Joshua P.
Chu, Deryn
TI Nano-Structured Bio-Inorganic Hybrid Material for High Performing Oxygen
Reduction Catalyst
SO ACS APPLIED MATERIALS & INTERFACES
LA English
DT Article
DE bio-inorganic hybrid catalyst; oxygen reduction reaction; Ag-Co; hemin;
graphene nanoplatelets
ID HIGH-AREA CARBON; AG NANOPARTICLES; ALKALINE MEDIA; HEAT-TREATMENT;
ELECTROREDUCTION; ELECTRODES; SILVER; ELECTROCATALYST; NANOFRAMES;
PORPHYRIN
AB In this study, we demonstrate a non-Pt nanostructured bioinorgaoic hybrid (BIH) catalyst for catalytic oxygen reduction in alkaline media. This catalyst was synthesized through biomaterial hemin, nanostructured Ag-Co alloy, and graphene nano platelets (GNP) by heat-treatment and ultrasonically processing. This hybrid catalyst has the advantages of the combined features of these bio and inorganic materials. A 10-fold improvement in catalytic activity (at 0.8 V vs RHE) is achieved in comparison of pure Ag nanoparticles (20-40 nm). The hybrid catalyst reaches 80% activity (at 0.8 V vs RHE) of the state-of-the-art catalyst (containing 40% Pt and 60% active carbon). Comparable catalytic stability for the hybrid catalyst with the Pt catalyst is observed by chronoamperometric experiment. The hybrid catalyst catalyzes 4-electron oxygen reduction to produce water with fast kinetic rate. The rate constant obtained from the hybrid catalyst (at 0.6 V vs RHE) is 4 times higher than that of pure Ag/GNP catalyst. A catalytic model is proposed to explain the oxygen reduction reaction at the BIH catalyst.
C1 [Jiang, Rongzhong; Tran, Dat T.; McClure, Joshua P.; Chu, Deryn] US Army Res Lab, Sensors & Electron Devices Directorate, Adelphi, MD 20783 USA.
RP Jiang, RZ (reprint author), US Army Res Lab, Sensors & Electron Devices Directorate, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM Rongzhong.jiang.civ@mail.mil
FU U.S. Department of the Army; U.S. Army Material Command
FX The authors would like to thank Dr. Wen-An Chiou and Dr. Sz-Chian Liou
at University of Maryland for assisting TEM and STEM analyses. Thanks to
Dr. Cynthia Lundgren for helpful discussions. Finally, thanks to the
U.S. Department of the Army and U.S. Army Material Command for
supporting this work.
NR 42
TC 2
Z9 2
U1 9
U2 46
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1944-8244
J9 ACS APPL MATER INTER
JI ACS Appl. Mater. Interfaces
PD AUG 26
PY 2015
VL 7
IS 33
BP 18530
EP 18539
DI 10.1021/acsami.5b04714
PG 10
WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary
SC Science & Technology - Other Topics; Materials Science
GA CQ0XN
UT WOS:000360322000043
PM 26280984
ER
PT J
AU Rokni, MR
Widener, CA
Champagne, VK
Crawford, GA
AF Rokni, M. R.
Widener, C. A.
Champagne, V. K.
Crawford, G. A.
TI Microstructure and mechanical properties of cold sprayed 7075 deposition
during non-isothermal annealing
SO SURFACE & COATINGS TECHNOLOGY
LA English
DT Article
DE Aluminum alloys; Cold spraying; Non-isothermal; Annealing; TEM
ID SEVERE PLASTIC-DEFORMATION; GAS-ATOMIZED POWDER; ZN-MG ALLOYS;
ALUMINUM-ALLOY; GRAIN-SIZE; HEAT-TREATMENT; NANOCRYSTALLINE MATERIALS;
STRENGTHENING MECHANISMS; ELEVATED-TEMPERATURES; INTERFACIAL REGION
AB This study presents microstructure and mechanical property relationships of cold-sprayed 7075 aluminum during non-isothermal annealing. Microstructure evolution during non-isothermal annealing from room temperature to 450 degrees C was performed using in-situ heating via a hot-stage transmission electron microscope. Additional characterization was performed using differential scanning calorimetry and X-ray diffraction. Grain size, dislocation density, microstrain, lattice parameter, and precipitation phenomena were evaluated as a function of annealing temperature. The results showed that cold spray processing accelerated the precipitation kinetics of strengthening phases in the microstructure, compared to the as-received cold spray powder, but did not affect the overall precipitation sequence. Also, pancaked grain structures, found at particle-particle interfaces within the deposition, were converted, due to recrystallization, to ultrafine-grained structures during annealing. The ultrafine-grained structures experienced limited grain growth during the annealing process. This was attributed to the nucleation of grain boundary precipitates in the as-sprayed material, primarily originating from grain boundary solute segregation present in the cold spray powder. Mechanical properties were evaluated using microhardness testing, after annealing, and correlated with microstructural analysis. When subjected to low temperature annealing (below 370 degrees C), the cold spray processed material had a lower microhardness than that found in conventional 7075 aluminum subjected to the same thermal treatment, due to the presence of inter-particle porosity in the cold spray microstructure. Annealing at temperatures above 370 degrees C, however, resulted in an increase in hardness, likely due to a reduction in inter-particle porosity and grain boundary strengthening associated with the retention of an ultrafine grain structure at high temperatures. (C) 2015 Elsevier B.V. All rights reserved.
C1 [Rokni, M. R.; Widener, C. A.; Crawford, G. A.] South Dakota Sch Mines & Technol, Dept Mat & Met Engn, Adv Mat Proc Ctr, Rapid City, SD 57701 USA.
[Champagne, V. K.] US Army Res Lab, Weapons & Mat Res Directorate, Aberdeen Proving Ground, MD USA.
RP Rokni, MR (reprint author), South Dakota Sch Mines & Technol, Dept Mat & Met Engn, Adv Mat Proc Ctr, Rapid City, SD 57701 USA.
EM reza.rokni@mines.sdsmt.edu; grant.crawford@sdsmt.edu
NR 67
TC 3
Z9 3
U1 2
U2 19
PU ELSEVIER SCIENCE SA
PI LAUSANNE
PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND
SN 0257-8972
J9 SURF COAT TECH
JI Surf. Coat. Technol.
PD AUG 25
PY 2015
VL 276
BP 305
EP 315
DI 10.1016/j.surfcoat.2015.07.016
PG 11
WC Materials Science, Coatings & Films; Physics, Applied
SC Materials Science; Physics
GA CQ4SJ
UT WOS:000360594600038
ER
PT J
AU Galvin, CJ
Bain, ED
Henke, A
Genzer, J
AF Galvin, Casey J.
Bain, Erich D.
Henke, Adam
Genzer, Jan
TI Instability of Surface-Grafted Weak Polyacid Brushes on Flat Substrates
SO MACROMOLECULES
LA English
DT Article
ID TRANSFER RADICAL POLYMERIZATION; POLY(ACRYLIC ACID) BRUSHES;
POLYELECTROLYTE BRUSHES; INITIATED POLYMERIZATION; PHYSICAL
INTERACTIONS; DENSITY GRADIENTS; CELL-CULTURE; BEHAVIOR; LAYERS;
MACROMOLECULES
AB We study the stability of weak polyacid brush (WPAB) gradients in aqueous media covering a range in grafting density (sigma) spanning 0.05-0.5 chains/nm(2) using two analogous surface-anchored bromoisobutyrate-based initiators for atom transfer radical polymerization (ATRP) bearing either an ester or amide linker. Variations in dry thickness of ester-based WPABs as a function of time and pH are consistent with WPAB degrafting via linker hydrolysis catalyzed by mechanical tension in the grafted chains. Sources of tension considered include high sigma, as well as swelling and electrostatic repulsion associated with increasing degree of deprotonation (alpha) of repeat units in the WP.AB. Normalized thickness of the WPAB decreases by a maximum amount at intermediate sigma between similar to 0.05-0.15 chains/nm(2), implying that contributions to tension by alpha are counterbalanced by charge regulation in the WPAB at high sigma. Amide-based WPABs are more stable up to 264 h incubation, suggesting that commonly used ester-bearing ATRP initiators are more susceptible to hydrolysis over the time scales examined.
C1 [Galvin, Casey J.; Bain, Erich D.; Genzer, Jan] N Carolina State Univ, Dept Chem & Biomol Engn, Raleigh, NC 27695 USA.
[Galvin, Casey J.] Okinawa Inst Sci Technol Grad Univ, Onna Son, Okinawa 9040497, Japan.
[Bain, Erich D.] US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
[Henke, Adam] Calif Inst Biomed Res, La Jolla, CA 92037 USA.
RP Genzer, J (reprint author), N Carolina State Univ, Dept Chem & Biomol Engn, Raleigh, NC 27695 USA.
EM jgenzer@ncsu.edu
RI Galvin, Casey/G-2948-2015
OI Galvin, Casey/0000-0001-7513-276X
FU National Science Foundation [DMR-0906572]; Micro/Bio/Nanofluidics Unit
of the Okinawa Institute of Science and Technology Graduate University;
[DMR-1404639]
FX This work was supported by the National Science Foundation under Grant
No. DMR-0906572. A partial support though the Grant no. DMR-1404639 is
also acknowledged. CJG acknowledges support from the
Micro/Bio/Nanofluidics Unit of the Okinawa Institute of Science and
Technology Graduate University while preparing this manuscript.
NR 44
TC 3
Z9 3
U1 3
U2 23
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0024-9297
EI 1520-5835
J9 MACROMOLECULES
JI Macromolecules
PD AUG 25
PY 2015
VL 48
IS 16
BP 5677
EP 5687
DI 10.1021/acs.macromol.5b01289
PG 11
WC Polymer Science
SC Polymer Science
GA CQ0YL
UT WOS:000360324400029
ER
PT J
AU Mait, JN
Beadie, G
Milojkovic, P
Flynn, RA
AF Mait, Joseph N.
Beadie, Guy
Milojkovic, Predrag
Flynn, Richard A.
TI Chromatic analysis and design of a first-order radial GRIN lens
SO OPTICS EXPRESS
LA English
DT Article
ID GRADIENT-INDEX LENSES; INHOMOGENEOUS LENSES; PARAXIAL ABERRATIONS;
OPTICS; MEDIA
AB From the expression for optical power of a radial first-order graded-index (GRIN) lens with curved surfaces, we derive an expression for chromatic aberration. Our expressions for optical power and chromatic aberration are valid under the paraxial approximation. By applying a series of further simplifying assumptions, namely a thin lens and thin GRIN, we derive a set of equations with which one can design an achromatic GRIN lens. We also derive expressions for the dispersive property of a GRIN element. Our analysis enables us to derive the relationship between material pairs that indicate their suitability as a material pair for a GRIN achromat. We use this relationship to search a standard glass catalog for attractive GRIN material pairs for a particular achromat design. We compare the optical performance of our GRIN design to that of a conventional homogeneous doublet and demonstrate that our approach is capable of identifying material pairs that perform well for achromatic GRIN lenses which would not generally be considered for conventional achromatic design. We also demonstrate our approach is capable of designing GRIN achromats with superior performance. (C) 2015 Optical Society of America
C1 [Mait, Joseph N.; Milojkovic, Predrag] US Army Res Lab, Adelphi, MD 20783 USA.
[Beadie, Guy; Flynn, Richard A.] US Naval Res Lab, Washington, DC 20375 USA.
RP Mait, JN (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM joseph.n.mait2.civ@mail.mil
NR 24
TC 5
Z9 5
U1 2
U2 5
PU OPTICAL SOC AMER
PI WASHINGTON
PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA
SN 1094-4087
J9 OPT EXPRESS
JI Opt. Express
PD AUG 24
PY 2015
VL 23
IS 17
BP 22069
EP 22086
DI 10.1364/OE.23.022069
PG 18
WC Optics
SC Optics
GA CS9NR
UT WOS:000362418300047
PM 26368181
ER
PT J
AU Loverde, JR
Pfister, BJ
AF Loverde, Joseph R.
Pfister, Bryan J.
TI Developmental axon stretch stimulates neuron growth while maintaining
normal electrical activity, intracellular calcium flux, and somatic
morphology
SO FRONTIERS IN CELLULAR NEUROSCIENCE
LA English
DT Article
DE axon stretch-growth; neuron development; nerve; regeneration; trauma;
injury
ID MECHANICAL TENSION; INJURY; REGENERATION; ELONGATION; NERVE;
CYTOMECHANICS; CULTURE
AB Elongation of nerve fibers intuitively occurs throughout mammalian development, and is synchronized with expansion of the growing body. While most tissue systems enlarge through mitosis and differentiation, elongation of nerve fibers is remarkably unique. The emerging paradigm suggests that axons undergo stretch as contiguous tissues enlarge between the proximal and distal segments of spanning nerve fibers. While stretch is distinct from growth, tension is a known stimulus which regulates the growth of axons. Here, we hypothesized that the axon stretch-growth process may be a natural form of injury, whereby regenerative processes fortify elongating axons in order to prevent disconnection. Harnessing the live imaging capability of our axon stretch-growth bioreactors, we assessed neurons both during and following stretch for biomarkers associated with injury. Utilizing whole-cell patch clamp recording, we found no evidence of changes in spontaneous action potential activity or degradation of elicited action potentials during real-time axon stretch at strains of up to 18% applied over 5 min. Unlike traumatic axonal injury, functional calcium imaging of the soma revealed no shifts in free intracellular calcium during axon stretch. Finally, the cross-sectional areas of nuclei and cytoplasms were normal, with no evidence of chromatolysis following week-long stretch-growth limited to the lower of 25% strain or 3 mm total daily stretch. The neuronal growth cascade coupled to stretch was concluded to be independent of the changes in membrane potential, action potential generation, or calcium flux associated with traumatic injury. While axon stretch-growth is likely to share overlap with regenerative processes, we conclude that developmental stretch is a distinct stimulus from traumatic axon injury.
C1 [Loverde, Joseph R.; Pfister, Bryan J.] New Jersey Inst Technol, Dept Biomed Engn, Ctr Injury Biomech Mat & Med, Newark, NJ 07102 USA.
[Loverde, Joseph R.] US Mil Acad, Dept Chem & Life Sci, Ctr Mol Sci, West Point, NY 10996 USA.
RP Pfister, BJ (reprint author), New Jersey Inst Technol, Dept Biomed Engn, 323 Martin Luther King Jr Blvd, Univ Hts, Newark, NJ 07102 USA.
EM pfister@njit.edu
FU New Jersey Commission on Brain Injury Research [07-3204-BIR-E-0]; NSF
CAREER [CBET-0747615]
FX This work was supported by the New Jersey Commission on Brain Injury
Research 07-3204-BIR-E-0 and the NSF CAREER CBET-0747615. We thank Dr.
Josh Berlin and Dr. George Magou for providing technical expertise in
functional calcium imaging and patch clamp recording. We also thank Dr.
Kyle Miller for his mentorship on axon stretch and experimental
methodologies. We also thank Mr. John Hoinowski, NJIT Biomedical
Engineering Design Studio, for his help in the fabrication of customized
device components. Finally, we thank John Blum from Honeywell for
providing Aclar film samples.
NR 31
TC 1
Z9 1
U1 3
U2 9
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015,
SWITZERLAND
SN 1662-5102
J9 FRONT CELL NEUROSCI
JI Front. Cell. Neurosci.
PD AUG 24
PY 2015
VL 9
AR 308
DI 10.3389/fncel.2015.00308
PG 15
WC Neurosciences
SC Neurosciences & Neurology
GA CP8XC
UT WOS:000360177300001
PM 26379492
ER
PT J
AU Zhao, BM
Keasey, SL
Tropea, JE
Lountos, GT
Dyas, BK
Cherry, S
Raran-Kurussi, S
Waugh, DS
Ulrich, RG
AF Zhao, Bryan M.
Keasey, Sarah L.
Tropea, Joseph E.
Lountos, George T.
Dyas, Beverly K.
Cherry, Scott
Raran-Kurussi, Sreejith
Waugh, David S.
Ulrich, Robert G.
TI Phosphotyrosine Substrate Sequence Motifs for Dual Specificity
Phosphatases
SO PLOS ONE
LA English
DT Article
ID PROTEIN-TYROSINE PHOSPHATASES; CELL LUNG-CANCER; CRYSTAL-STRUCTURE;
KINASE PHOSPHATASE-1; CATALYTIC MECHANISM; ANGSTROM RESOLUTION; CDC25
PHOSPHATASE; ACTIVATION; INHIBITORS; VIRUS
AB Protein tyrosine phosphatases dephosphorylate tyrosine residues of proteins, whereas, dual specificity phosphatases (DUSPs) are a subgroup of protein tyrosine phosphatases that dephosphorylate not only Tyr(P) residue, but also the Ser(P) and Thr(P) residues of proteins. The DUSPs are linked to the regulation of many cellular functions and signaling pathways. Though many cellular targets of DUSPs are known, the relationship between catalytic activity and substrate specificity is poorly defined. We investigated the interactions of peptide substrates with select DUSPs of four types: MAP kinases (DUSP1 and DUSP7), atypical (DUSP3, DUSP14, DUSP22 and DUSP27), viral (variola VH1), and Cdc25 (A-C). Phosphatase recognition sites were experimentally determined by measuring dephosphorylation of 6,218 microarrayed Tyr(P) peptides representing confirmed and theoretical phosphorylation motifs from the cellular proteome. A broad continuum of dephosphorylation was observed across the microarrayed peptide substrates for all phosphatases, suggesting a complex relationship between substrate sequence recognition and optimal activity. Further analysis of peptide dephosphorylation by hierarchical clustering indicated that DUSPs could be organized by substrate sequence motifs, and peptide-specificities by phylogenetic relationships among the catalytic domains. The most highly dephosphorylated peptides represented proteins from 29 cell-signaling pathways, greatly expanding the list of potential targets of DUSPs. These newly identified DUSP substrates will be important for examining structure-activity relationships with physiologically relevant targets.
C1 [Zhao, Bryan M.; Keasey, Sarah L.; Dyas, Beverly K.; Ulrich, Robert G.] US Army Med Res Inst Infect Dis, Mol & Translat Sci Div, Frederick, MD 21702 USA.
[Zhao, Bryan M.] Geneva Fdn, Tacoma, WA 98402 USA.
[Tropea, Joseph E.; Lountos, George T.; Cherry, Scott; Raran-Kurussi, Sreejith; Waugh, David S.] NCI, Macromol Crystallog Lab, Ctr Canc Res, Frederick, MD 21702 USA.
[Lountos, George T.] Leidos Biomed Res Inc, Basic Sci Program, Frederick Natl Lab Canc Res, Frederick, MD 21702 USA.
RP Ulrich, RG (reprint author), US Army Med Res Inst Infect Dis, Mol & Translat Sci Div, Frederick, MD 21702 USA.
EM rulrich@bhsai.org
FU Geneva Foundation; Leidos Biomedical Research, Inc.
FX The Geneva Foundation and Leidos Biomedical Research, Inc. provided
support in the form of salaries for authors BMZ and GTL, respectively,
but did not have any additional role in the study design, data
collection and analysis, decision to publish, or preparation of the
manuscript. The specific roles of these authors are articulated in the
'author contributions' section
NR 61
TC 1
Z9 1
U1 0
U2 7
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD AUG 24
PY 2015
VL 10
IS 8
AR e0134984
DI 10.1371/journal.pone.0134984
PG 19
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CP5VA
UT WOS:000359951900010
PM 26302245
ER
PT J
AU Clayton, JD
Knap, J
AF Clayton, J. D.
Knap, J.
TI Nonlinear phase field theory for fracture and twinning with analysis of
simple shear
SO PHILOSOPHICAL MAGAZINE
LA English
DT Article
DE fracture; twinning; elasticity; crystal; phase field; shear deformation
ID GRADIENT DAMAGE MODELS; BRITTLE-FRACTURE; NUMERICAL EXPERIMENTS;
THEORETICAL STRENGTH; CRACK-PROPAGATION; SINGLE-CRYSTALS; SHOCK-WAVE;
DEFORMATION; CONTINUUM; COMPRESSION
AB A phase field theory for coupled twinning and fracture in single crystal domains is developed. Distinct order parameters denote twinned and fractured domains, finite strains are addressed and elastic nonlinearity is included via a neo-Hookean strain energy potential. The governing equations and boundary conditions are derived; an incremental energy minimization approach is advocated for prediction of equilibrium microstructural morphologies under quasi-static loading protocols. Aspects of the theory are analysed in detail for a material element undergoing simple shear deformation. Exact analytical and/or one-dimensional numerical solutions are obtained in dimensionless form for stress states, stability criteria and order parameter profiles at localized fractures or twinning zones. For sufficient applied strain, the relative likelihood of localized twinning vs. localized fracture is found to depend only on the ratio of twin boundary surface energy to fracture surface energy. Predicted criteria for shear stress-driven fracture or twinning are often found to be in closer agreement with test data for several types of real crystals than those based on the concept of theoretical strength.
C1 [Clayton, J. D.; Knap, J.] US Army, Res Lab, Aberdeen, MD 21005 USA.
[Clayton, J. D.] Univ Maryland, A James Clark Sch Engn, College Pk, MD 20742 USA.
RP Clayton, JD (reprint author), US Army, Res Lab, Aberdeen, MD 21005 USA.
EM john.d.clayton1.civ@mail.mil
RI Clayton, John/C-7760-2009
NR 74
TC 5
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U1 2
U2 8
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1478-6435
EI 1478-6443
J9 PHILOS MAG
JI Philos. Mag.
PD AUG 23
PY 2015
VL 95
IS 24
BP 2661
EP 2696
DI 10.1080/14786435.2015.1076176
PG 36
WC Materials Science, Multidisciplinary; Metallurgy & Metallurgical
Engineering; Physics, Applied; Physics, Condensed Matter
SC Materials Science; Metallurgy & Metallurgical Engineering; Physics
GA CQ5MH
UT WOS:000360648100005
ER
PT J
AU Billings, E
Sanders-Buell, E
Bose, M
Bradfield, A
Lei, E
Kijak, GH
Arroyo, MA
Kibaya, RM
Scott, PT
Wasunna, MK
Sawe, FK
Shaffer, DN
Birx, DL
McCutchan, FE
Michael, NL
Robb, ML
Kim, JH
Tovanabutra, S
AF Billings, Erik
Sanders-Buell, Eric
Bose, Meera
Bradfield, Andrea
Lei, Esther
Kijak, Gustavo H.
Arroyo, Miguel A.
Kibaya, Rukia M.
Scott, Paul T.
Wasunna, Monique K.
Sawe, Frederick K.
Shaffer, Douglas N.
Birx, Deborah L.
McCutchan, Francine E.
Michael, Nelson L.
Robb, Merlin L.
Kim, Jerome H.
Tovanabutra, Sodsai
TI The Number and Complexity of Pure and Recombinant HIV-1 Strains Observed
within Incident Infections during the HIV and Malaria Cohort Study
Conducted in Kericho, Kenya, from 2003 to 2006
SO PLOS ONE
LA English
DT Article
ID FEMALE SEX WORKERS; TYPE-1 SUBTYPES; RHESUS-MONKEYS; DISEASE
PROGRESSION; GENOME SEQUENCES; RAKAI DISTRICT; FOLLOW-UP; CHALLENGES;
VACCINE; UGANDA
AB Characterization of HIV-1 subtype diversity in regions where vaccine trials are conducted is critical for vaccine development and testing. This study describes the molecular epidemiology of HIV-1 within a tea-plantation community cohort in Kericho, Kenya. Sixty-three incident infections were ascertained in the HIV and Malaria Cohort Study conducted in Kericho from 2003 to 2006. HIV-1 strains from 58 of those individuals were full genome characterized and compared to two previous Kenyan studies describing 41 prevalent infections from a blood bank survey (1999-2000) and 21 infections from a higher-risk cohort containing a mix of incident and prevalent infections (2006). Among the 58 strains from the community cohort, 43.1% were pure subtypes (36.2% A1, 5.2% C, and 1.7% G) and 56.9% were intersubtype recombinants (29.3% A1D, 8.6% A1CD, 6.9% A1A2D, 5.2% A1C, 3.4% A1A2CD, and 3.4% A2D). This diversity and the resulting genetic distance between the observed strains will need to be addressed when vaccine immunogens are chosen. In consideration of current vaccine development efforts, the strains from these three studies were compared to five candidate vaccines (each of which are viral vectored, carrying inserts corresponding to parts of gag, pol, and envelope), which have been developed for possible use in sub-Saharan Africa. The sequence comparison between the observed strains and the candidate vaccines indicates that in the presence of diverse recombinants, a bivalent vaccine is more likely to provide T-cell epitope coverage than monovalent vaccines even when the inserts of the bivalent vaccine are not subtype-matched to the local epidemic.
C1 [Billings, Erik; Sanders-Buell, Eric; Bose, Meera; Bradfield, Andrea; Lei, Esther; Kijak, Gustavo H.; Scott, Paul T.; McCutchan, Francine E.; Robb, Merlin L.; Tovanabutra, Sodsai] Henry M Jackson Fdn, US Mil HIV Res Program, Rockville, MD 20817 USA.
[Arroyo, Miguel A.; Birx, Deborah L.; Michael, Nelson L.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA.
[Kibaya, Rukia M.] Kenya Govt Med Res Ctr, Walter Reed Project Clin Res Ctr, Kericho, Kenya.
[Wasunna, Monique K.] Kenya Govt Med Res Ctr, Kericho, Kenya.
[Wasunna, Monique K.] Kenya Govt Med Res Ctr, Nairobi, Kenya.
[Sawe, Frederick K.] Kenya Govt Med Res Ctr, Walter Reed Project HIV Program, Kericho, Kenya.
[Shaffer, Douglas N.] Kenya Walter Reed Project HIV Program, US Army Med Res Unit, Kericho, Kenya.
[Kim, Jerome H.] Int Vaccine Inst, Seoul, South Korea.
RP Tovanabutra, S (reprint author), Henry M Jackson Fdn, US Mil HIV Res Program, Rockville, MD 20817 USA.
EM stovanabutra@hivresearch.org
OI Arroyo, Miguel/0000-0001-7416-8867
FU United States Military HIV Research Program (the Walter Reed Army
Institute of Research); United States Military HIV Research Program
(Henry M. Jackson Foundation for the Advancement of Military Medicine);
Henry M. Jackson Foundation for the Advancement of Military Medicine,
Inc. [DAMD17-98-2-7007, W81XWH-04-2-0005, W81XWH-07-2-0067,
W81XWH-11-2-0174]; U.S. Department of Defense (DOD) [DAMD17-98-2-7007,
W81XWH-04-2-0005, W81XWH-07-2-0067, W81XWH-11-2-0174]
FX The Walter Reed Army Institute of Research Institutional Research Board
human use protocol #855 (RV142), "HIV and Malaria Cohort Study Among
Plantation Workers and Adult Dependents in Kericho, Kenya," is funded
through the United States Military HIV Research Program (the Walter Reed
Army Institute of Research and the Henry M. Jackson Foundation for the
Advancement of Military Medicine). This work was supported by
cooperative agreements (DAMD17-98-2-7007, W81XWH-04-2-0005,
W81XWH-07-2-0067, W81XWH-11-2-0174) between the Henry M. Jackson
Foundation for the Advancement of Military Medicine, Inc., and the U.S.
Department of Defense (DOD).
NR 47
TC 0
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U1 0
U2 0
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD AUG 19
PY 2015
VL 10
IS 8
AR e0135124
DI 10.1371/journal.pone.0135124
PG 17
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CP6SN
UT WOS:000360018600036
PM 26287814
ER
PT J
AU Bracis, C
Gurarie, E
Van Moorter, B
Goodwin, RA
AF Bracis, Chloe
Gurarie, Eliezer
Van Moorter, Bram
Goodwin, R. Andrew
TI Memory Effects on Movement Behavior in Animal Foraging
SO PLOS ONE
LA English
DT Article
ID SPATIAL MEMORY; POPULATION-DYNAMICS; RANDOM-WALKS; HOME RANGES;
SPACE-USE; MODELS; SEAGRASS; MECHANISMS; EMERGENCE; SELECTION
AB An individual's choices are shaped by its experience, a fundamental property of behavior important to understanding complex processes. Learning and memory are observed across many taxa and can drive behaviors, including foraging behavior. To explore the conditions under which memory provides an advantage, we present a continuous-space, continuous-time model of animal movement that incorporates learning and memory. Using simulation models, we evaluate the benefit memory provides across several types of landscapes with variable-quality resources and compare the memory model within a nested hierarchy of simpler models (behavioral switching and random walk). We find that memory almost always leads to improved foraging success, but that this effect is most marked in landscapes containing sparse, contiguous patches of high-value resources that regenerate relatively fast and are located in an otherwise devoid landscape. In these cases, there is a large payoff for finding a resource patch, due to size, value, or locational difficulty. While memory-informed search is difficult to differentiate from other factors using solely movement data, our results suggest that disproportionate spatial use of higher value areas, higher consumption rates, and consumption variability all point to memory influencing the movement direction of animals in certain ecosystems.
C1 [Bracis, Chloe] Univ Washington, Quantitat Ecol & Resource Management, Seattle, WA 98195 USA.
[Bracis, Chloe] Senckenberg Gesell Nat Forsch, Senckenberg Biodivers & Climate Res Ctr BiK F, Frankfurt, Main, Germany.
[Bracis, Chloe] Goethe Univ Frankfurt, D-60054 Frankfurt, Main, Germany.
[Gurarie, Eliezer] Univ Maryland, Dept Biol, College Pk, MD 20742 USA.
[Van Moorter, Bram] Norwegian Univ Sci & Technol, Ctr Conservat Biol, N-7034 Trondheim, Norway.
[Van Moorter, Bram] Norwegian Inst Nat Res NINA, Trondheim, Norway.
[Goodwin, R. Andrew] US Army Engineer Res & Dev Ctr, Environm Lab, Portland, OR USA.
RP Bracis, C (reprint author), Univ Washington, Quantitat Ecol & Resource Management, Seattle, WA 98195 USA.
EM cbracis@uw.edu
OI Gurarie, Eliezer/0000-0002-8666-9674; Van Moorter,
Bram/0000-0002-3196-1993
FU U.S. Army Engineer Research and Development Center (ERDC); Cold Regions
Research and Engineering Laboratory; AT24 Program; Geospatial Research
and Engineering Program; ERDC BAA; ERDC Construction Engineering
Research Laboratory; National Science Foundation [ABI-1062411];
Norwegian Research Council
FX Research was conducted under sponsorship of the U.S. Army Engineer
Research and Development Center (ERDC, http://www.erdc.usace.army.mil),
Cold Regions Research and Engineering Laboratory, AT24 and Geospatial
Research and Engineering Programs (Bert Davis, Randy Hill). C.B. was
partially funded through an ERDC BAA awarded to James Anderson,
University of Washington. R.G. was partially funded through the ERDC
Construction Engineering Research Laboratory, Military Ranges and Lands
Program (Alan Anderson). E.G. was partially funded by National Science
Foundation (http://www.nsf.gov) grant ABI-1062411. B.M. was funded by
Norwegian Research Council's (http://www.forskningsradet.no) PredClim
grant to B.-E. Saether. The funders had no role in study design, data
collection and analysis, decision to publish, or preparation of the
manuscript.
NR 67
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U1 6
U2 38
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD AUG 19
PY 2015
VL 10
IS 8
AR e0136057
DI 10.1371/journal.pone.0136057
PG 21
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CP6SN
UT WOS:000360018600102
PM 26288228
ER
PT J
AU Keyshar, K
Gong, YJ
Ye, GL
Brunetto, G
Zhou, W
Cole, DP
Hackenberg, K
He, YM
Machado, L
Kabbani, M
Hart, AHC
Li, B
Galvao, DS
George, A
Vajtai, R
Tiwary, CS
Ajayan, PM
AF Keyshar, Kunttal
Gong, Yongji
Ye, Gonglan
Brunetto, Gustavo
Zhou, Wu
Cole, Daniel P.
Hackenberg, Ken
He, Yongmin
Machado, Leonardo
Kabbani, Mohamad
Hart, Amelia H. C.
Li, Bo
Galvao, Douglas S.
George, Antony
Vajtai, Robert
Tiwary, Chandra Sekhar
Ajayan, Pulickel M.
TI Chemical Vapor Deposition of Monolayer Rhenium Disulfide (ReS2)
SO ADVANCED MATERIALS
LA English
DT Article
DE 2D materials; chemical vapor deposition; renium disulfide; transition
metal dichalcogenides
ID HYDROGEN EVOLUTION REACTION; HEXAGONAL BORON-NITRIDE; HIGH-QUALITY
MONOLAYER; MOS2 ATOMIC LAYERS; HIGH-PERFORMANCE; GRAIN-BOUNDARY;
NANOSHEETS; TRANSISTORS; GROWTH; DICHALCOGENIDES
C1 [Keyshar, Kunttal; Ye, Gonglan; Hackenberg, Ken; He, Yongmin; Kabbani, Mohamad; Hart, Amelia H. C.; Li, Bo; George, Antony; Vajtai, Robert; Tiwary, Chandra Sekhar; Ajayan, Pulickel M.] Rice Univ, Dept Mat Sci & Nanoengn, Houston, TX 77005 USA.
[Gong, Yongji] Rice Univ, Dept Chem, Houston, TX 77005 USA.
[Brunetto, Gustavo; Machado, Leonardo; Galvao, Douglas S.] State Univ Campinas UNICAMP, IFGW DFA, Dept Appl Phys, BR-13083859 Campinas, SP, Brazil.
[Zhou, Wu] Oak Ridge Natl Lab, Mat Sci & Technol Div, Oak Ridge, TN 37831 USA.
[Cole, Daniel P.] US Army Res Lab, Vehicle Technol Directorate, Aberdeen Proving Ground, MD 21005 USA.
RP Tiwary, CS (reprint author), Rice Univ, Dept Mat Sci & Nanoengn, Houston, TX 77005 USA.
EM cst311@gmail.com; ajayan@rice.edu
RI Zhou, Wu/D-8526-2011; UNICAMP, CCES - /J-7787-2015; Gong,
Yongji/L-7628-2016; Inst. of Physics, Gleb Wataghin/A-9780-2017;
Machado, Leonardo/E-2081-2017
OI Zhou, Wu/0000-0002-6803-1095;
FU Army Research Laboratory [W911NF-1O-l-0052]; AFOSR (Air Force Office of
Scientific Research) [FA9550-14-1-0268]; CNPq; CAPES; FAPESP; Center for
Computational Engineering and Sciences at Unicamp through the
FAPESP/CEPID [2013/08293-7]
FX Research was sponsored by the Army Research Laboratory and was
accomplished under Cooperative Agreement No. W911NF-1O-l-0052. The views
and conclusions contained in this document are those of the authors and
should not be interpreted as representing the official policies, either
expressed or implied, of the Army Research Laboratory or the U.S.
Government. The U.S. Government is authorized to reproduce and
distribute reprints for Government purposes notwithstanding any
copyright notation herein. The Research was also sponsored by AFOSR (Air
Force Office of Scientific Research) under Award No. FA9550-14-1-0268.
The authors would also like to acknowlege Sidong Lei from Rice
University for aid in device measurements. Gustavo Brunetto, Leonardo
Machado and Douglas S. Galvao acknowledge financial support from the
Brazilian Agencies CNPq, CAPES and FAPESP and also thank the Center for
Computational Engineering and Sciences at Unicamp for financial support
through the FAPESP/CEPID Grant 2013/08293-7.
NR 45
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U1 37
U2 175
PU WILEY-V C H VERLAG GMBH
PI WEINHEIM
PA BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY
SN 0935-9648
EI 1521-4095
J9 ADV MATER
JI Adv. Mater.
PD AUG 19
PY 2015
VL 27
IS 31
BP 4640
EP 4648
DI 10.1002/adma.201501795
PG 9
WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience &
Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied;
Physics, Condensed Matter
SC Chemistry; Science & Technology - Other Topics; Materials Science;
Physics
GA CP5HI
UT WOS:000359911500021
PM 26140355
ER
PT J
AU Laporta, GZ
Linton, YM
Wilkerson, RC
Bergo, ES
Nagaki, SS
Sant'Ana, DC
Sallum, MAM
AF Laporta, Gabriel Zorello
Linton, Yvonne-Marie
Wilkerson, Richard C.
Bergo, Eduardo Sterlino
Nagaki, Sandra Sayuri
Sant'Ana, Denise Cristina
Mureb Sallum, Maria Anice
TI Malaria vectors in South America: current and future scenarios
SO PARASITES & VECTORS
LA English
DT Article
DE Anopheles darlingi; Albitarsis Complex; Climate change; Ecological niche
model; Plasmodium falciparum
ID NYSSORHYNCHUS ALBITARSIS DIPTERA; POLYMERASE CHAIN-REACTION;
CLIMATE-CHANGE; ANOPHELES-NYSSORHYNCHUS; POTENTIAL DISTRIBUTION;
PLASMODIUM-FALCIPARUM; CULICIDAE; COMPLEX; BRAZIL; TRANSMISSION
AB Background: Malaria remains a significant public health issue in South America. Future climate change may influence the distribution of the disease, which is dependent on the distribution of those Anopheles mosquitoes competent to transmit Plasmodium falciparum. Herein, predictive niche models of the habitat suitability for P. falciparum, the current primary vector Anopheles darlingi and nine other known and/or potential vector species of the Neotropical Albitarsis Complex, were used to document the current situation and project future scenarios under climate changes in South America in 2070.
Methods: To build each ecological niche model, we employed topography, climate and biome, and the currently defined distribution of P. falciparum, An. darlingi and nine species comprising the Albitarsis Complex in South America. Current and future (i.e., 2070) distributions were forecast by projecting the fitted ecological niche model onto the current environmental situation and two scenarios of simulated climate change. Statistical analyses were performed between the parasite and each vector in both the present and future scenarios to address potential vector roles in the dynamics of malaria transmission.
Results: Current distributions of malaria vector species were associated with that of P. falciparum, confirming their role in transmission, especially An. darlingi, An. marajoara and An. deaneorum. Projected climate changes included higher temperatures, lower water availability and biome modifications. Regardless of future scenarios considered, the geographic distribution of P. falciparum was exacerbated in 2070 South America, with the distribution of the pathogen covering 35-46 % of the continent. As the current primary vector An. darlingi showed low tolerance for drier environments, the projected climate change would significantly reduce suitable habitat, impacting both its distribution and abundance. Conversely, climate generalist members of the Albitarsis Complex showed significant spatial and temporal expansion potential in 2070, and we conclude these species will become more important in the dynamics of malaria transmission in South America.
Conclusions: Our data suggest that climate and landscape effects will elevate the importance of members of the Albitarsis Complex in malaria transmission in South America in 2070, highlighting the need for further studies addressing the bionomics, ecology and behaviours of the species comprising the Albitarsis Complex.
C1 [Laporta, Gabriel Zorello; Nagaki, Sandra Sayuri; Sant'Ana, Denise Cristina; Mureb Sallum, Maria Anice] Univ Sao Paulo, Fac Saude Publ, Dept Epidemiol, BR-01255 Sao Paulo, SP, Brazil.
[Laporta, Gabriel Zorello] Univ Sao Paulo, Fac Med, Lab Informat Med, Sao Paulo, SP, Brazil.
[Laporta, Gabriel Zorello] Fac Med ABC, Setor Posgrad Pesquisa & Inovacao, Santo Andre, SP, Brazil.
[Linton, Yvonne-Marie; Wilkerson, Richard C.] Walter Reed Army Inst Res, Div Entomol, Silver Spring, MD USA.
[Linton, Yvonne-Marie; Wilkerson, Richard C.] Smithsonian Inst, Walter Reed Biosystemat Unit, Museum Support Ctr, Suitland, MD USA.
[Linton, Yvonne-Marie; Wilkerson, Richard C.] Smithsonian Inst, Dept Entomol, Natl Museum Nat Hist, Washington, DC 20560 USA.
[Linton, Yvonne-Marie] Uniformed Serv Univ Hlth Sci, Dept Preventat Med & Biostat, Bethesda, MD 20814 USA.
[Bergo, Eduardo Sterlino] Secretaria Estado Saude Sao Paulo, Superintendencia Controle Endemias SUCEN, Araraquara, SP, Brazil.
RP Laporta, GZ (reprint author), Univ Sao Paulo, Fac Saude Publ, Dept Epidemiol, BR-01255 Sao Paulo, SP, Brazil.
EM gabrielzorelo@usp.br
RI Laporta, Gabriel/B-8662-2012; Nagaki, Sandra/G-7069-2016;
OI Laporta, Gabriel/0000-0001-7412-9390
FU Sao Paulo Research Foundation (FAPESP) [2014/26229-7]; Brazilian
National Council for Scientific and Technological Development (CNPq)
[301666/2011-3]; National Institute of Health, USA [R01 AI50139-02];
FAPESP [2014/09774-1, 2015/09669-6]
FX We gratefully acknowledge financial support from the Sao Paulo Research
Foundation (FAPESP, Grant no. 2014/26229-7), the Brazilian National
Council for Scientific and Technological Development (CNPq, Grant no.
301666/2011-3) to MAMS; RCW was partially supported by an award from the
National Institute of Health, USA (grant R01 AI50139-02 to Jan Conn).
GZL is currently financially supported by FAPESP Grant no. 2014/09774-1
and FAPESP Grant no. 2015/09669-6. Funders of this study had no role in
the design, collection, analysis or interpretation of the results, nor
in the writing of this report or the decision to publish it. Part of
this research was performed under a Memorandum of Understanding between
the Walter Reed Army Institute of Research and the Smithsonian
Institution, with institutional support provided by both organizations.
The material to be published reflects the views of the authors and
should not be construed to represent those of the US Department of the
Army or the US Department of Defense. This manuscript was prepared
whilst YML held a National Research Council (NRC) Senior Research
Associateship Award at the Walter Reed Army Institute of Research.
NR 55
TC 6
Z9 6
U1 2
U2 37
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1756-3305
J9 PARASITE VECTOR
JI Parasites Vectors
PD AUG 19
PY 2015
VL 8
AR 426
DI 10.1186/s13071-015-1038-4
PG 13
WC Parasitology
SC Parasitology
GA CP3DE
UT WOS:000359756200003
PM 26283539
ER
PT J
AU Petersen, EJ
Diamond, SA
Kennedy, AJ
Goss, GG
Ho, K
Lead, J
Hanna, SK
Hartmann, NB
Hund-Rinke, K
Mader, B
Manier, N
Pandard, P
Salinas, ER
Sayre, P
AF Petersen, Elijah J.
Diamond, Stephen A.
Kennedy, Alan J.
Goss, Greg G.
Ho, Kay
Lead, Jamie
Hanna, Shannon K.
Hartmann, Nanna B.
Hund-Rinke, Kerstin
Mader, Brian
Manier, Nicolas
Pandard, Pascal
Salinas, Edward R.
Sayre, Phil
TI Adapting OECD Aquatic Toxicity Tests for Use with Manufactured
Nanomaterials: Key Issues and Consensus Recommendations
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Review
ID ECOTOXICITY TEST METHODS; WALLED CARBON NANOTUBES; NATURAL
ORGANIC-MATTER; ENVIRONMENTALLY RELEVANT CONDITIONS; TITANIUM-DIOXIDE
NANOPARTICLES; CAPPED SILVER NANOPARTICLES; PLASMA-MASS SPECTROMETRY;
DAPHNIA-MAGNA; GOLD NANOPARTICLES; ENGINEERED NANOMATERIALS
AB The unique or enhanced properties of manufactured nanomaterials (MNs) suggest that their use in nanoenabled products will continue to increase. This will result in increased potential for human and environmental exposure to MNs during manufacturing, use, and disposal of nanoenabled products. Scientifically based risk assessment for MNs necessitates the development of reproducible, standardized hazard testing methods such as those provided by the Organisation of Economic Cooperation and Development (OECD). Currently, there is no comprehensive guidance on how best to address testing issues specific to MN particulate, fibrous, or colloidal properties. This paper summarizes the findings from an expert workshop convened to develop a guidance document that addresses the difficulties encountered when testing MNs using OECD aquatic and sediment test guidelines. Critical components were identified by workshop participants that require specific guidance for MN testing: preparation of dispersions, dose metrics, the importance and challenges associated with maintaining and monitoring exposure levels, and the need for reliable methods to quantify MNs in complex media. To facilitate a scientific advance in the consistency of nanoecotoxicology test results, we identify and discuss critical considerations where expert consensus recommendations were and were not achieved and provide specific research recommendations to resolve issues for which consensus was not reached. This process will enable the development of prescriptive testing guidance for MNs. Critically, we highlight the need to quantify and properly interpret and express exposure during the bioassays used to determine hazard values.
C1 [Petersen, Elijah J.; Hanna, Shannon K.] Natl Inst Stand & Technol, Biosyst & Biomat Div, Mat Measurement Lab, Gaithersburg, MD 20899 USA.
[Diamond, Stephen A.] NanoSafe Inc, Midwest Div, Duluth, MN 55802 USA.
[Kennedy, Alan J.] US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA.
[Goss, Greg G.] Univ Alberta, Natl Res Council, Dept Biol Sci, Edmonton, AB T6G 2E9, Canada.
[Goss, Greg G.] Univ Alberta, Natl Res Council, Natl Inst Nanotechnol, Edmonton, AB T6G 2E9, Canada.
[Ho, Kay] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Atlantic Ecol Div, Narragansett, RI 02882 USA.
[Lead, Jamie] Univ S Carolina, Arnold Sch Publ Hlth, Dept Environm Hlth Sci, Ctr Environm Nanosci & Risk, Columbia, SC 29036 USA.
[Hartmann, Nanna B.] Tech Univ Denmark, Dept Environm Engn, DK-2800 Lyngby, Denmark.
[Hund-Rinke, Kerstin] Fraunhofer Inst Mol Biol & Appl Ecol, D-57392 Schmallenberg, Germany.
[Mader, Brian] 3M Co, Environm Lab, St Paul, MN 55144 USA.
[Manier, Nicolas; Pandard, Pascal] Inst Natl Environm Ind & Risques INERIS, F-60550 Verneuil En Halatte, France.
[Salinas, Edward R.] BASF SE, Expt Toxicol & Ecol, D-67056 Ludwigshafen, Germany.
[Sayre, Phil] US EPA, Off Pollut Prevent & Tox, Washington, DC 20460 USA.
RP Kennedy, AJ (reprint author), US Army Engineer Res & Dev Ctr, Environm Lab, Vicksburg, MS 39180 USA.
EM Alan.J.Kennedy@usace.army.mil; phil.sayre@verizon.net
RI Petersen, Elijah/E-3034-2013; Hartmann, Nanna B./A-1678-2009
OI Hartmann, Nanna B./0000-0002-0442-245X
FU Army Environmental Quality and Installations (EQI) Technology Research
Program; SmartState Center for Environmental Nanoscience and Risk;
Environment Canada; Natural Sciences and Engineering Research Council of
Canada (NSERC); National Institute of Nanotechnology; Danish
Environmental Protection Agency
FX We acknowledge the significant contribution of workshop attendees who
did not contribute to the writing of this paper: Zachary Collier, Teresa
Fernandez, Jeff Gallagher, Richard Handy, Dale Hoff, Amuel Kennedy,
Laura Nazef, Jeffery Steevens, Norishisa Tatarazako, David Tobias, Doris
Voelker, and Kathrin Schwirn. Frank von der Kammer is thanked for giving
a presentation at the workshop. Permission to publish this material was
granted by the U.S. Army Corps of Engineers Chief of Engineers and by
the U.S. EPA Office of Pollution Prevention and Toxics. A portion of
this work was funded through the Army Environmental Quality and
Installations (EQI) Technology Research Program (Dr. Elizabeth Ferguson,
Technical Director) for the U.S. Army Engineer Research & Development
Center (ERDC). J.L. acknowledges financial support from the SmartState
Center for Environmental Nanoscience and Risk. G.G.G. acknowledges
financial support from Environment Canada, the Natural Sciences and
Engineering Research Council of Canada (NSERC), and the National
Institute of Nanotechnology. N.B.H. received funding from the Danish
Environmental Protection Agency.
NR 166
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U1 12
U2 57
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
EI 1520-5851
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD AUG 18
PY 2015
VL 49
IS 16
BP 9532
EP 9547
DI 10.1021/acs.est.5b00997
PG 16
WC Engineering, Environmental; Environmental Sciences
SC Engineering; Environmental Sciences & Ecology
GA CP4ZS
UT WOS:000359891700019
PM 26182079
ER
PT J
AU Elder, RM
Neupane, MR
Chantawansri, TL
AF Elder, Robert M.
Neupane, Mahesh R.
Chantawansri, Tanya L.
TI Stacking order dependent mechanical properties of graphene/MoS2 bilayer
and trilayer heterostructures
SO APPLIED PHYSICS LETTERS
LA English
DT Article
ID MOLECULAR-DYNAMICS; ELASTIC PROPERTIES; MOLYBDENUM-DISULFIDE; MOS2
TRANSISTORS; MONOLAYER MOS2; TRANSITION; NANOSHEETS; METALS; LAYERS
AB Transition metal dichalcogenides (TMDC) such as molybdenum disulfide (MoS2) are two-dimensional materials that show promise for flexible electronics and piezoelectric applications, but their weak mechanical strength is a barrier to practical use. In this work, we perform nanoindentation simulations using atomistic molecular dynamics to study the mechanical properties of heterostructures formed by combining MoS2 with graphene. We consider both bi- and tri-layer heterostructures formed with MoS2 either supported or encapsulated by graphene. Mechanical properties, such as Young's modulus, bending modulus, ultimate tensile strength, and fracture strain, are extracted from nanoindentation simulations and compared to the monolayer and homogeneous bilayer systems. We observed that the heterostructures, regardless of the stacking order, are mechanically more robust than the mono-and bi-layer MoS2, mainly due to the mechanical reinforcement provided by the graphene layer. The magnitudes of ultimate strength and fracture strain are similar for both the bi-and tri-layer heterostructures, but substantially larger than either the mono-and bi-layer MoS2. Our results demonstrate the potential of graphene-based heterostructures to improve the mechanical properties of TMDC materials.
C1 [Elder, Robert M.; Neupane, Mahesh R.; Chantawansri, Tanya L.] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA.
RP Elder, RM (reprint author), US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA.
EM robert.elder26.ctr@mail.mil; mahesh.neupane.ctr@mail.mil
RI Elder, Robert/H-9886-2016;
OI Neupane, Mahesh/0000-0002-8210-3307
NR 52
TC 3
Z9 3
U1 15
U2 84
PU AMER INST PHYSICS
PI MELVILLE
PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA
SN 0003-6951
EI 1077-3118
J9 APPL PHYS LETT
JI Appl. Phys. Lett.
PD AUG 17
PY 2015
VL 107
IS 7
AR 073101
DI 10.1063/1.4928752
PG 5
WC Physics, Applied
SC Physics
GA CQ1WI
UT WOS:000360390500044
ER
PT J
AU Lee, AJ
Peiris, FC
Brill, G
Doyle, K
Myers, TH
AF Lee, A. J.
Peiris, F. C.
Brill, G.
Doyle, K.
Myers, T. H.
TI Dielectric functions and carrier concentrations of Hg1-xCdxSe films
determined by spectroscopic ellipsometry
SO APPLIED PHYSICS LETTERS
LA English
DT Article
ID OPTICAL-PROPERTIES; SPECTRAL ELLIPSOMETRY; CRITICAL-POINTS; ALLOYS;
ABSORPTION
AB Spectroscopic ellipsometry, ranging from 35meV to 6 eV, was used to determine the dielectric functions of a series of molecular beam epitaxy-grown Hg1-xCdxSe thin films deposited on both ZnTe/Si(112) and GaSb(112) substrates. The fundamental band gap as well as two higher-order electronic transitions blue-shift with increasing Cd composition in Hg1-xCdxSe, as expected. Representing the free carrier absorption with a Drude oscillator, we found that the effective masses of Hg1-xCdxSe (grown on ZnTe/Si) vary between 0.028 and 0.050 times the free electron mass, calculated using the values of carrier concentration and the mobility obtained through Hall measurements. Using these effective masses, we determined the carrier concentrations of Hg1-xCdxSe samples grown on GaSb, which is of significance as films grown on such doped-substrates posit ambiguous results when measured by conventional Hall experiments. These models can serve as a basis for monitoring Cd-composition during sample growth through in-situ spectroscopic ellipsometry. (C) 2015 AIP Publishing LLC.
C1 [Lee, A. J.; Peiris, F. C.] Kenyon Coll, Dept Phys, Gambier, OH 43022 USA.
[Brill, G.; Doyle, K.] US Army Res Lab, Adelphi, MD 20783 USA.
[Myers, T. H.] Texas State Univ, Dept Phys, San Marcos, TX 78666 USA.
RP Peiris, FC (reprint author), Kenyon Coll, Dept Phys, Gambier, OH 43022 USA.
EM peirisf@kenyon.edu
OI Lee, Aidan/0000-0003-1209-190X
FU National Science Foundation [DMR-1207169]; U.S. Army Research
Laboratory; U.S. Army Research Office [W911NF-10-2-0103,
W911NF-10-1-0335, W911NF-12-2-0019]
FX The work at Kenyon was funded by the National Science Foundation
DMR-1207169 grant. Support for the growth and study of the
Hg1-xCdxSe samples was provided by the U.S. Army
Research Laboratory and the U.S. Army Research Office under
Contract/Grant Nos. W911NF-10-2-0103, W911NF-10-1-0335, and
W911NF-12-2-0019.
NR 30
TC 0
Z9 0
U1 2
U2 9
PU AMER INST PHYSICS
PI MELVILLE
PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA
SN 0003-6951
EI 1077-3118
J9 APPL PHYS LETT
JI Appl. Phys. Lett.
PD AUG 17
PY 2015
VL 107
IS 7
AR 072102
DI 10.1063/1.4928555
PG 4
WC Physics, Applied
SC Physics
GA CQ1WI
UT WOS:000360390500021
ER
PT J
AU Sablon, K
Li, Y
Vagidov, N
Mitin, V
Little, JW
Hier, H
Sergeev, A
AF Sablon, K.
Li, Y.
Vagidov, N.
Mitin, V.
Little, J. W.
Hier, H.
Sergeev, A.
TI GaAs quantum dot solar cell under concentrated radiation
SO APPLIED PHYSICS LETTERS
LA English
DT Article
ID BUILT-IN CHARGE; EFFICIENCY; SUNS
AB Effects of concentrated solar radiation on photovoltaic performance are investigated in well-developed GaAs quantum dot (QD) solar cells with 1-Sun efficiencies of 18%-19%. In these devices, the conversion processes are enhanced by nanoscale potential barriers and/or AlGaAs atomically thin barriers around QDs, which prevent photoelectron capture to QDs. Under concentrated radiation, the short circuit current increases proportionally to the concentration and the open circuit voltage shows the logarithmic increase. In the range up to hundred Suns, the contributions of QDs to the photocurrent are proportional to the light concentration. The ideality factors of 1.1-1.3 found from the VOC-Sun characteristics demonstrate effective suppression of recombination processes in barrier-separated QDs. The conversion efficiency shows the wide maximum in the range of 40-90 Suns and reaches 21.6%. Detailed analysis of I-V-Sun characteristics shows that at low intensities, the series resistance decreases inversely proportional to the concentration and, at similar to 40 Suns, reaches the plateau determined mainly by the front contact resistance. Improvement of contact resistance would increase efficiency to above 24% at thousand Suns. (C) 2015 AIP Publishing LLC.
C1 [Sablon, K.; Little, J. W.; Hier, H.; Sergeev, A.] US Army Res Lab, Adelphi, MD 20783 USA.
[Li, Y.; Vagidov, N.; Mitin, V.; Sergeev, A.] SUNY Buffalo, EE Dept, Buffalo, NY 14260 USA.
[Vagidov, N.] US Air Force Res Lab, Albuquerque, NM 87117 USA.
RP Sablon, K (reprint author), US Army Res Lab, Adelphi, MD 20783 USA.
FU ARL; NSF [ECS-1236459]; NRC Research Associateship Program
FX The work of K.S., J.W.L., and H.H. was supported by ARL and research at
UB was supported by NSF (ECS-1236459). A.S. and N.V. gratefully
acknowledge support from NRC Research Associateship Program. The authors
are grateful to S. Oktyabrsky, D. Wilt, and M. Yakimov for valuable
discussions.
NR 30
TC 2
Z9 2
U1 6
U2 21
PU AMER INST PHYSICS
PI MELVILLE
PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA
SN 0003-6951
EI 1077-3118
J9 APPL PHYS LETT
JI Appl. Phys. Lett.
PD AUG 17
PY 2015
VL 107
IS 7
AR 073901
DI 10.1063/1.4928669
PG 5
WC Physics, Applied
SC Physics
GA CQ1WI
UT WOS:000360390500065
ER
PT J
AU Nouranian, S
Gwaltney, SR
Baskes, MI
Tschopp, MA
Horstemeyer, MF
AF Nouranian, Sasan
Gwaltney, Steven R.
Baskes, Michael I.
Tschopp, Mark A.
Horstemeyer, Mark F.
TI Simulations of tensile bond rupture in single alkane molecules using
reactive interatomic potentials
SO CHEMICAL PHYSICS LETTERS
LA English
DT Article
ID DYNAMICS SIMULATION; FORCE-FIELD; HYDROCARBONS; POLYETHYLENE;
DEFORMATION; BEHAVIOR; POLYMER; PACKAGE
AB Molecular simulations were performed to study the energetics and geometries of bond rupture in single alkane molecules using three reactive hydrocarbon potentials: (1) modified embedded-atom method (MEAM) for saturated hydrocarbons, (2) ReaxFF, and (3) second-generation REBO. The total energy/force versus strain, strain at fracture, and strain energy release were compared for a homologous series of normal alkanes (ethane to undecane) with generalization to polyethylene. The C-C bond distances and C-C-C bond angles were quantified, and a fragment analysis was performed. Overall, the MEAM and ReaxFF potentials are in reasonable agreement with first-principles data with MEAM matching DFT-calculated lowest energy fragments. (c) 2015 Elsevier B.V. All rights reserved.
C1 [Nouranian, Sasan; Horstemeyer, Mark F.] Mississippi State Univ, Ctr Adv Vehicular Syst, Mississippi State, MS 39762 USA.
[Gwaltney, Steven R.] Mississippi State Univ, Dept Chem, Mississippi State, MS 39762 USA.
[Baskes, Michael I.] Mississippi State Univ, Dept Aerosp Engn, Mississippi State, MS 39762 USA.
[Tschopp, Mark A.] US Army Res Lab, Aberdeen Proving Ground, MD 21005 USA.
[Horstemeyer, Mark F.] Mississippi State Univ, Dept Mech Engn, Mississippi State, MS 39762 USA.
RP Nouranian, S (reprint author), Univ Mississippi, Dept Chem Engn, University, MS 38677 USA.
EM sasan@olemiss.edu
RI Tschopp, Mark/B-1594-2008;
OI Tschopp, Mark/0000-0001-8471-5035; Gwaltney, Steven/0000-0003-3833-5087;
Horstemeyer, Mark/0000-0003-4230-0063; Nouranian,
Sasan/0000-0002-8319-2786
FU U.S. Army Engineer Research and Development Center (ERDC)
[W15QKN-13-9-0001]
FX This work was sponsored by the U.S. Army Engineer Research and
Development Center (ERDC) under contract no. W15QKN-13-9-0001. Special
thanks go to Robert Moser for his support.
NR 34
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U1 1
U2 13
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0009-2614
EI 1873-4448
J9 CHEM PHYS LETT
JI Chem. Phys. Lett.
PD AUG 16
PY 2015
VL 635
BP 278
EP 284
DI 10.1016/j.cplett.2015.06.071
PG 7
WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical
SC Chemistry; Physics
GA CS7BU
UT WOS:000362239300051
ER
PT J
AU Dretsch, MN
Kelly, MP
Coldren, RL
Parish, RV
Russell, ML
AF Dretsch, Michael N.
Kelly, Mark P.
Coldren, Rodney L.
Parish, Robert V.
Russell, Michael L.
TI No Significant Acute and Subacute Differences between Blast and Blunt
Concussions across Multiple Neurocognitive Measures and Symptoms in
Deployed Soldiers
SO JOURNAL OF NEUROTRAUMA
LA English
DT Article
DE ANAM; cognitive screening; concussion mechanism; deployment; military
ID TRAUMATIC BRAIN-INJURY; POSTCONCUSSIVE SYMPTOMS; SERVICE MEMBERS; MILD
TBI; ASSOCIATION; MECHANISM; VETERANS; FORCES
AB Seventy-one deployed U.S. Army soldiers who presented for concussion care due to either blast or blunt mechanisms within 72h of injury were assessed using the Military Acute Concussion Evaluation, the Automated Neuropsychological Assessment Metrics (ANAM), traditional neuropsychological tests, and health status questionnaires. Follow-up ANAM testing was performed 10d after initial testing (+/- 5d). Twenty-one soldiers were excluded: two for poor effort and 19 who had combined blast/blunt injuries. Of the remaining 50 male participants, 34 had blast injuries and 16 had blunt injuries. There were no statistically significant differences between blast injury and blunt injury participants in demographic, physical, or psychological health factors, concussive symptoms, or automated and traditional neurocognitive testing scores within 72h post-injury. In addition, follow-up ANAM scores up to 15d post-injury were not significantly different (available on 21 blast-injured and 13 blunt-injured subjects). Pre-injury baseline ANAM scores were compared where available, and revealed no statistically significant differences between 22 blast injury and eight blunt injury participants. These findings suggest there are no significant differences between mechanisms of injury during both the acute and subacute periods in neurobehavioral concussion sequelae while deployed in a combat environment. The current study supports the use of sports/mechanical concussion models for early concussion management in the deployed setting and exploration of variability in potential long-term outcomes.
C1 [Dretsch, Michael N.] US Army Aeromed Res Lab, Warfighter Hlth Div, Ft Rucker, AL USA.
[Dretsch, Michael N.] Natl Intrepid Ctr Excellence, Bethesda, MD 20889 USA.
[Kelly, Mark P.] Walter Reed Natl Mil Med Ctr, Neuropsychol Serv Assessment Div, Bethesda, MD USA.
[Coldren, Rodney L.] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA.
[Parish, Robert V.] Irwin Army Community Hosp, Dept Behav Hlth, Ft Riley, KS USA.
[Russell, Michael L.] Vet Hlth Adm, Ctr Excellence Res Returning War Vet, Waco, TX USA.
RP Dretsch, MN (reprint author), Natl Intrepid Ctr Excellence, Bethesda, MD 20889 USA.
EM Michael.n.dretsch.mil@health.mil
FU U.S. Army Medical Research Acquisition Activity [W81XWIH-09-2-0057]
FX The authors acknowledge the assistance of numerous individuals whose
efforts were critical in the performance of this study. We thank SSG
David Lopez and SGT Pedro Cruz of the U.S. Army Aeromedical Research
Laboratory for their diligent data collection efforts. This work was
supported by the U.S. Army Medical Research Acquisition Activity
[W81XWIH-09-2-0057]. The content of this paper was adapted from a poster
presentation at the 2012 annual Meeting of the International
Neuropsychological Society, Montreal, Canada, February, 2012.
NR 27
TC 2
Z9 2
U1 2
U2 4
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 0897-7151
EI 1557-9042
J9 J NEUROTRAUM
JI J. Neurotrauma
PD AUG 15
PY 2015
VL 32
IS 16
BP 1217
EP 1222
DI 10.1089/neu.2014.3637
PG 6
WC Critical Care Medicine; Clinical Neurology; Neurosciences
SC General & Internal Medicine; Neurosciences & Neurology
GA CU9RU
UT WOS:000363883400005
PM 25367048
ER
PT J
AU Quinn, CM
Audet, GN
Charkoudian, N
Leon, LR
AF Quinn, Carrie M.
Audet, Gerald N.
Charkoudian, Nisha
Leon, Lisa R.
TI Cardiovascular and thermoregulatory dysregulation over 24 h following
acute heat stress in rats
SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
LA English
DT Article
DE thermoregulation; heart rate; heat stroke; autonomic nervous system;
blood pressure; iNOS
ID ARTERIAL BAROREFLEX CONTROL; SYMPATHETIC-NERVE ACTIVITY; WHOLE-BODY;
VASOCONSTRICTOR AGENTS; SKELETAL-MUSCLE; BLOOD-PRESSURE; HUMANS;
RESPONSES; STROKE; HYPERTHERMIA
AB The influences of severe heat stroke (HS) on cardiovascular function during recovery are incompletely understood. We hypothesized that HS would elicit a heart rate (HR) increase persisting through 24 h of recovery due to hemodynamic, thermoregulatory, and inflammatory events, necessitating tachycardia to support mean arterial pressure (MAP). Core temperature (T-c), HR, and MAP were measured via radiotelemetry in conscious male Fischer 344 rats (n = 22; 282.4 +/- 3.5 g) during exposure to 37 degrees C ambient temperature until a maximum T-c of 42.0 degrees C, and during recovery at 20 degrees C ambient temperature through 24 h. Rats were divided into Mild, Moderate, and Severe groups based on pathophysiology. HS rats exhibited hysteresis relative to T-c with HR higher for a given T-c during recovery compared with heating (P < 0.0001). "Reverse" hysteresis occurred in MAP with pressure during cooling lower than heating per degree T-c (P < 0.0001). Mild HS rats showed tachycardia [P < 0.01 vs. control (Con)] through 8 h of recovery, elevated MAP (P < 0.05 vs. Con) for the initial 5 h of recovery, with sustained hyperthermia (P < 0.05 vs. Con) through 24 h. Moderate HS rats showed significant tachycardia (P < 0.01 vs. Con), normal MAP (P > 0.05 vs. Con), and rebound hyperthermia from 4 to 24 h post-HS (P < 0.05 vs. Con). Severe HS rats showed tachycardia (P < 0.05 vs. Con), hypotension (P < 0.01 vs. Con), and hypothermia for 24 h (P < 0.05 vs. Con). Severe HS rats showed 14-and 12-fold increase in heart and liver inducible nitric oxide synthase expression, respectively. Hypotension and hypothermia in Severe HS rats was consistent with inducible nitric oxide synthase-mediated systemic vasodilation. These findings provide mechanistic insight into hemodynamic and thermoregulatory impairments during 24 h of HS recovery.
C1 [Quinn, Carrie M.; Audet, Gerald N.; Charkoudian, Nisha; Leon, Lisa R.] US Army, Environm Med Res Inst, Thermal & Mountain Med Div, Natick, MA 01760 USA.
RP Quinn, CM (reprint author), US Army, Environm Med Res Inst, Thermal & Mountain Med Div, Kansas St,Bldg 42, Natick, MA 01760 USA.
EM carrie.m.quinn.mil@mail.mil
FU United States Army Medical Research and Materiel Command
FX This research was funded by the United States Army Medical Research and
Materiel Command.
NR 42
TC 2
Z9 2
U1 2
U2 7
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6135
EI 1522-1539
J9 AM J PHYSIOL-HEART C
JI Am. J. Physiol.-Heart Circul. Physiol.
PD AUG 15
PY 2015
VL 309
IS 4
BP H557
EP H564
DI 10.1152/ajpheart.00918.2014
PG 8
WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular
Disease
SC Cardiovascular System & Cardiology; Physiology
GA CP2UT
UT WOS:000359733400006
PM 26071550
ER
PT J
AU Lu, YY
Kotoka, R
Ligda, JP
Yarmolenko, SN
Schuster, BE
Wei, Q
AF Lu, Y. Y.
Kotoka, R.
Ligda, J. P.
Yarmolenko, S. N.
Schuster, B. E.
Wei, Q.
TI Morphological and mechanical stability of HCP-based multilayer nanofilms
at elevated temperatures
SO SURFACE & COATINGS TECHNOLOGY
LA English
DT Article
DE Metallic multilayer; Thermal stability; Microstructure; Nanoindentation
hardness
ID SCALE-DEPENDENT DEFORMATION; PLATE-LIKE STRUCTURES; THERMAL-STABILITY;
SHAPE INSTABILITIES; MAGNETIC-PROPERTIES; CO/CU MULTILAYERS;
PHASE-TRANSITION; COLUMNAR GROWTH; THIN-FILMS; MICROSTRUCTURE
AB The thermal stability of Mg/Ti multilayer nanofilms was investigated by examining their microstructure and nanoindentation hardness after annealing at various temperatures and time periods. The multilayers with individual layer thickness h >= 5 nm exhibit excellent capability of maintaining the lamellar microstructure and high strength up to 200 degrees C for annealing time up to 2.0 h. The annealed muldlayer films with h = 2.5 nm are still highly textured but characterized with discontinuous layer interfaces, in which the transition of atomic arrangement from hexagonal close-packed (HCP) to body-centered cubic (BCC) structure was observed at columnar boundaries. The degradation of uniform lamellar microstructure is related to the decrease of hardness with annealing temperature at this size scale. A diffusion based instability mechanism was proposed for this typical HCP-based nanoscale multilayer system. (C) 2015 Elsevier B.V. All rights reserved.
C1 [Lu, Y. Y.; Wei, Q.] Univ N Carolina, Dept Mech Engn, Charlotte, NC 28223 USA.
[Kotoka, R.; Yarmolenko, S. N.] N Carolina Agr & Tech State Univ, Dept Mech Engn, Greensboro, NC 27411 USA.
[Ligda, J. P.; Schuster, B. E.] US Army, Res Lab, WMRD, Aberdeen, MD 21005 USA.
RP Wei, Q (reprint author), Univ N Carolina, Dept Mech Engn, Charlotte, NC 28223 USA.
EM qwei@uncc.edu
RI Wei, Qiuming/B-7579-2008; Yarmolenko, Sergey/E-6819-2017
FU Education Ministry of the People's Republic of China; US Army Research
Laboratory [W911QX-08-C-0073]; National Science Foundation through ERC
FX Y.Y. Lu is grateful for the financial support from the Education
Ministry of the People's Republic of China during her pursuit for her
PhD at The University of North Carolina at Charlotte. This research work
is supported by US Army Research Laboratory under Contract No.
W911QX-08-C-0073. S. N. Yarmolenko has been supported by National
Science Foundation through ERC.
NR 39
TC 3
Z9 3
U1 1
U2 18
PU ELSEVIER SCIENCE SA
PI LAUSANNE
PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND
SN 0257-8972
J9 SURF COAT TECH
JI Surf. Coat. Technol.
PD AUG 15
PY 2015
VL 275
BP 142
EP 147
DI 10.1016/j.surfcoat.2015.05.027
PG 6
WC Materials Science, Coatings & Films; Physics, Applied
SC Materials Science; Physics
GA CM5UG
UT WOS:000357753900021
ER
PT J
AU Fan, YF
Geren, IN
Dong, JB
Lou, JL
Wen, WH
Conrad, F
Smith, TJ
Smith, LA
Ho, MF
Pires-Alves, M
Wilson, BA
Marks, JD
AF Fan, Yongfeng
Geren, Isin N.
Dong, Jianbo
Lou, Jianlong
Wen, Weihua
Conrad, Fraser
Smith, Theresa J.
Smith, Leonard A.
Ho, Mengfei
Pires-Alves, Melissa
Wilson, Brenda A.
Marks, James D.
TI Monoclonal Antibodies Targeting the Alpha-Exosite of Botulinum
Neurotoxin Serotype/A Inhibit Catalytic Activity
SO PLOS ONE
LA English
DT Article
ID MOTOR-NERVE TERMINALS; TOXIN TYPE-A; LIGHT-CHAIN; HEAVY-CHAIN;
CLOSTRIDIAL NEUROTOXINS; MOLECULAR EVOLUTION; STRUCTURAL INSIGHT;
CRYSTAL-STRUCTURE; PROTEIN-RECEPTOR; IMMUNE GLOBULIN
AB The paralytic disease botulism is caused by botulinum neurotoxins (BoNT), multi-domain proteins containing a zinc endopeptidase that cleaves the cognate SNARE protein, thereby blocking acetylcholine neurotransmitter release. Antitoxins currently used to treat botulism neutralize circulating BoNT but cannot enter, bind to or neutralize BoNT that has already entered the neuron. The light chain endopeptidase domain (LC) of BoNT serotype A (BoNT/A) was targeted for generation of monoclonal antibodies (mAbs) that could reverse paralysis resulting from intoxication by BoNT/A. Single-chain variable fragment (scFv) libraries from immunized humans and mice were displayed on the surface of yeast, and 19 BoNT/A LC-specific mAbs were isolated by using fluorescence-activated cell sorting (FACS). Affinities of the mAbs for BoNT/A LC ranged from a K-D value of 9.0x10(-11) M to 3.53x10(-8) M(mean K-D 5.38x10(-9) M and median K-D 1.53x10(-9) M), as determined by flow cytometry analysis. Eleven mAbs inhibited BoNT/A LC catalytic activity with IC50 values ranging from 8.3 similar to 73x10(-9) M. The fine epitopes of selected mAbs were also mapped by alanine-scanning mutagenesis, revealing that the inhibitory mAbs bound the alpha-exosite region remote from the BoNT/A LC catalytic center. The results provide mAbs that could prove useful for intracellular reversal of paralysis post-intoxication and further define epitopes that could be targeted by small molecule inhibitors.
C1 [Fan, Yongfeng; Geren, Isin N.; Dong, Jianbo; Lou, Jianlong; Wen, Weihua; Conrad, Fraser; Marks, James D.] Univ Calif San Francisco, Dept Anesthesia, San Francisco, CA 94143 USA.
[Smith, Theresa J.] US Army Med Inst Infect Dis, Mol & Translat Sci Div, Ft Detrick, MD USA.
[Smith, Leonard A.] US Army Med Inst Infect Dis, Med Countermeasures Technol, US Army Med Res & Mat Command, Ft Detrick, MD USA.
[Ho, Mengfei; Pires-Alves, Melissa; Wilson, Brenda A.] Univ Illinois, Dept Microbiol, Urbana, IL USA.
RP Marks, JD (reprint author), Univ Calif San Francisco, Dept Anesthesia, San Francisco, CA 94143 USA.
EM jim.marks@ucsf.edu
FU NIH/NIAID [U01 AI056493, R21/R33 AI101504, U01 AI075502, U54 AI0571530];
DTRA [HDTRA1-07-C-0030]
FX This work was funded in part by NIH/NIAID under Cooperative Agreement
U01 AI056493 (to JDM), DTRA contract HDTRA1-07-C-0030 (to JDM),
NIH/NIAID R21/R33 AI101504 (to BAW), NIH/NIAID U01 AI075502 (to BAW),
and NIH/NIAID subcontract under U54 AI0571530 (to BAW). Opinions,
interpretations, conclusions, and recommendations are those of the
authors and not necessarily endorsed by the U.S. Army, the National
Institute of Allergy and Infectious Diseases, or the National Institutes
of Health. The funders had no role in study design, data collection and
analysis, decision to publish, or preparation of the manuscript.
NR 58
TC 3
Z9 3
U1 2
U2 4
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD AUG 14
PY 2015
VL 10
IS 8
AR e0135306
DI 10.1371/journal.pone.0135306
PG 23
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CO9KD
UT WOS:000359493600060
PM 26275214
ER
PT J
AU Levy, JW
Simasathien, S
Watanaveeradej, V
Bhoomiboonchoo, P
Fernandez, S
Jarman, RG
Klungthong, C
Gibbons, RV
Kerdpanich, P
Piboonbanakit, D
Chirabandhu, T
Yoon, IK
AF Levy, Jens W.
Simasathien, Sriluck
Watanaveeradej, Veerachai
Bhoomiboonchoo, Piraya
Fernandez, Stefan
Jarman, Richard G.
Klungthong, Chonticha
Gibbons, Robert V.
Kerdpanich, Phirangkool
Piboonbanakit, Danaband
Chirabandhu, Tundorn
Yoon, In-Kyu
TI Influenza Vaccine Effectiveness in the Tropics: Moderate Protection in a
Case Test-Negative Analysis of a Hospital-Based Surveillance Population
in Bangkok between August 2009 and January 2013
SO PLOS ONE
LA English
DT Article
ID SEASONAL INFLUENZA; CIRCULATION; VIRUSES
AB Influenza in the tropics occurs year round with peaks that correspond variably to temperate regions. However, data on influenza vaccine effectiveness (VE) in the tropics is sparse. We report on the effectiveness of influenza vaccine to prevent medically attended laboratory confirmed influenza from sentinel surveillance conducted at a Thai military medical facility in Bangkok, Thailand from August 2009 to January 2013. Patients >= 6 months old presenting with influenza-like illness underwent combined nasal/throat swabs which were tested by influenza RT-PCR. A case test-negative study design was used to evaluate VE. Of 2999 samples available for analysis, 1059 (35.3%) were PCR-positive (cases) and 1940 (64.6%) were PCR-negative (test-negative controls). Five hundred and seven (16.9%) of these patients reported being vaccinated within the previous 12 months. Periods of high and low influenza activity were defined based on publicly available Thai Ministry of Public Health data. Overall VE adjusted for age and epiweek was found to be 50.1% (95% CI: 35.0, 61.9%). The May to April adjusted VE for year 2010, 2011 and 2012 was 57.7% (95% CI: 33.7, 73.8%), 57.1% (95% CI: 35.2, 68.3%) and 37.6% (95% CI: 3.5, 62.9%). During high influenza activity in years with the same vaccine formulation, the adjusted VE was 54.9% (95% CI: 38.9, 66.9%). VE appeared to be much higher during high versus low influenza activity periods. The adjusted point estimate for VE was highest in the 18-49 year age group (76.6%) followed by 6-23 months (58.1%) and 2-17 years (52.5%). Adjusted estimates were not done for those >= 50 years of age due to small numbers. VE in patients with underlying disease was 75.5% compared to 48.0% in those without. Our findings demonstrate moderate protection by influenza vaccination and support the utility of influenza vaccination in the tropics including in very young children and those with underlying disease.
C1 [Levy, Jens W.; Bhoomiboonchoo, Piraya; Fernandez, Stefan; Klungthong, Chonticha; Gibbons, Robert V.; Yoon, In-Kyu] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand.
[Simasathien, Sriluck; Watanaveeradej, Veerachai; Kerdpanich, Phirangkool; Piboonbanakit, Danaband; Chirabandhu, Tundorn] Phramongkutklao Hosp, Bangkok, Thailand.
[Jarman, Richard G.] Walter Reed Army Inst Res, Viral Dis Branch, Silver Spring, MD USA.
RP Levy, JW (reprint author), Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand.
EM jenslevy@gmail.com
FU Armed Forces Health Surveillance Center - Global Emerging Infections
Surveillance and Response System (AFHSC-GEIS)
FX The funding was provided by Armed Forces Health Surveillance Center -
Global Emerging Infections Surveillance and Response System (AFHSC-GEIS
with no specific grant number). The funding source had no role in the
study design, data collection, analysis and interpretation, manuscript
writing or manuscript submission for publication.
NR 26
TC 1
Z9 1
U1 0
U2 0
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD AUG 12
PY 2015
VL 10
IS 8
AR e0134318
DI 10.1371/journal.pone.0134318
PG 14
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CO9JT
UT WOS:000359492300039
PM 26267430
ER
PT J
AU Rodriguez, OL
Allison, PG
Whittington, WR
Francis, DK
Rivera, OG
Chou, K
Gong, X
Butler, TM
Burroughs, JF
AF Rodriguez, O. L.
Allison, P. G.
Whittington, W. R.
Francis, D. K.
Rivera, O. G.
Chou, K.
Gong, X.
Butler, T. M.
Burroughs, J. F.
TI Dynamic tensile behavior of electron beam additive manufactured Ti6Al4V
SO MATERIALS SCIENCE AND ENGINEERING A-STRUCTURAL MATERIALS PROPERTIES
MICROSTRUCTURE AND PROCESSING
LA English
DT Article
DE Electron microscopy; Powder metallurgy; Plasticity; Strain measurement;
Titanium alloys
ID HIGH-STRAIN-RATE; MECHANICAL-PROPERTIES; BIOMEDICAL APPLICATIONS;
TI-6AL-4V; MICROSTRUCTURE; TITANIUM; DEFORMATION; FRACTURE; STEEL;
TEMPERATURES
AB High rate and quasi-static tensile experiments examined strain rate dependence on flow stress and strain hardening of additive manufactured Ti6Al4V. Variations on strain-hardening coefficient indicate that the rate of thermal softening is greater than strain hardening during plastic deformation. Strain rate sensitivity calculations within the plastic strain regime suggest changes in deformation mechanisms. Fractography revealed cup-and-cone fracture for quasi-static samples and shear mechanisms for high rate samples. As-deposited microstructure consisted of bimodal alpha+beta with the presence of secondary martensitic phase. (C) 2015 Elsevier B.V. All rights reserved.
C1 [Rodriguez, O. L.; Allison, P. G.; Rivera, O. G.; Chou, K.; Gong, X.] Univ Alabama, Dept Mech Engn, Tuscaloosa, AL 35487 USA.
[Whittington, W. R.; Francis, D. K.] Mississippi State Univ, Dept Mech Engn, Starkville, MS USA.
[Butler, T. M.] Univ Alabama, Dept Met Engn, Tuscaloosa, AL 35487 USA.
[Burroughs, J. F.] US Army ERDC, Geotech & Struct Lab, Vicksburg, MS 39180 USA.
RP Allison, PG (reprint author), Univ Alabama, Dept Mech Engn, Tuscaloosa, AL 35487 USA.
EM pallison@eng.ua.edu
NR 27
TC 1
Z9 1
U1 10
U2 32
PU ELSEVIER SCIENCE SA
PI LAUSANNE
PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND
SN 0921-5093
EI 1873-4936
J9 MAT SCI ENG A-STRUCT
JI Mater. Sci. Eng. A-Struct. Mater. Prop. Microstruct. Process.
PD AUG 12
PY 2015
VL 641
BP 323
EP 327
DI 10.1016/j.msea.2015.06.069
PG 5
WC Nanoscience & Nanotechnology; Materials Science, Multidisciplinary;
Metallurgy & Metallurgical Engineering
SC Science & Technology - Other Topics; Materials Science; Metallurgy &
Metallurgical Engineering
GA CN9YQ
UT WOS:000358807500038
ER
PT J
AU Unlu, I
Soares, JW
Steeves, DM
Whitten, JE
AF Unlu, Ilyas
Soares, Jason W.
Steeves, Diane M.
Whitten, James E.
TI Photocatalytic Activity and Fluorescence of Gold/Zinc Oxide
Nanoparticles Formed by Dithiol Linking
SO LANGMUIR
LA English
DT Article
ID AU NANOPARTICLES; METAL NANOPARTICLES; GOLD NANOPARTICLES; NANOROD
ARRAYS; ZNO NANOWIRES; GAS SENSORS; PERFORMANCE; PHOTOLUMINESCENCE;
ENHANCEMENT; EMISSION
AB Monolayer-protected gold nanoparticles (AuNPs) with average diameters of 2-4 nm have been covalently attached to zinc oxide nanorods using dithiol ligands. Electron microscopy and Raman spectroscopy show that ozone treatment or annealing at 300 or 450 degrees C increases the average diameter of the AuNPs to 6, 8, and 14 (+/- 1) nm, respectively, and decomposes the organic layers to various degrees. These treatments locate the AuNPs closer to the nanorods. Heating and subsequent ozone exposure changes the color of the as-prepared nanocomposite powder from blue to purple due to oxidation of the outer layer of the AuNPs, and heating to 300 degrees C changes it to pink due to oxygen desorption. ZnO nanorods have a bimodal photoluminescence spectrum that consists of an ultraviolet excitonic peak and a visible, surface defect-related peak. Ozone treatment and annealing of the nanocomposite decreases the intensities of both peaks due to quenching by the AuNPs, but the visible peak is affected less. The photocatalytic efficiency of the nanocomposites toward oxidative degradation of rhodamine B has been measured and follows the order 300 degrees C > 450 degrees C > ozone treated approximate to as-prepared approximate to bare ZnO. The greater efficiency of the annealed samples likely arises from decreased electron hole pair recombination rates.
C1 [Unlu, Ilyas; Whitten, James E.] Univ Massachusetts Lowell, Dept Chem, Lowell, MA 01854 USA.
[Unlu, Ilyas; Whitten, James E.] Univ Massachusetts Lowell, Ctr High Rate Nanomfg, Lowell, MA 01854 USA.
[Soares, Jason W.; Steeves, Diane M.] US Army, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA.
RP Whitten, JE (reprint author), Univ Massachusetts Lowell, Dept Chem, Lowell, MA 01854 USA.
EM James_Whitten@uml.edu
FU U.S. Army Natick Soldier Research, Development, and Engineering Center
[W911QY-13-2-0003]
FX The authors acknowledge the assistance of Dr. Peng Wang at Bruker Optics
in obtaining the Raman spectra. This work is supported by U.S. Army
Natick Soldier Research, Development, and Engineering Center, under
Cooperative Agreement #W911QY-13-2-0003. Approved for public release
(U15-079).
NR 42
TC 5
Z9 5
U1 6
U2 37
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0743-7463
J9 LANGMUIR
JI Langmuir
PD AUG 11
PY 2015
VL 31
IS 31
BP 8718
EP 8725
DI 10.1021/acs.langmuir.5b01632
PG 8
WC Chemistry, Multidisciplinary; Chemistry, Physical; Materials Science,
Multidisciplinary
SC Chemistry; Materials Science
GA CO9MM
UT WOS:000359499900024
PM 26172335
ER
PT J
AU Karmakar, S
Meyers, RE
AF Karmakar, Sanjit
Meyers, Ronald E.
TI Color controllable polarization entanglement generation in optical fiber
at telecommunication wavelengths
SO OPTICS EXPRESS
LA English
DT Article
ID PHOTON-PAIR GENERATION; QUANTUM ENTANGLEMENT; STIMULATED RAMAN;
CONVERSION; LIGHT; STATE
AB This article proposes a polarized entangled photon source in optical fiber with low Raman noise that features the controllable generation of specific signal and idler wavelengths (colors) by varying the pump power. The novel two color source can provide needed telecom entangled photon wavelengths for applications in quantum communications, quantum computing, and quantum imaging. (C) 2015 Optical Society of America
C1 [Karmakar, Sanjit] Univ Maryland Baltimore Cty, Dept Phys, Baltimore, MD 21250 USA.
[Meyers, Ronald E.] US Army Res Lab, Adelphi, MD 20783 USA.
RP Meyers, RE (reprint author), US Army Res Lab, Adelphi, MD 20783 USA.
EM ronald.e.meyers6.civ@mail.mil
FU U.S. Army Research Laboratory (ARL)
FX The authors thank K. Deacon, A. Tunick, and P. Hemmer for helpful
discussions. This research was supported and funded by the U.S. Army
Research Laboratory (ARL). S. Karmakar is a Post-Doctoral Fellow at ARL
(W911NF-11-2-0074).
NR 37
TC 0
Z9 0
U1 2
U2 6
PU OPTICAL SOC AMER
PI WASHINGTON
PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA
SN 1094-4087
J9 OPT EXPRESS
JI Opt. Express
PD AUG 10
PY 2015
VL 23
IS 16
BP 20605
EP 20616
DI 10.1364/OE.23.020605
PG 12
WC Optics
SC Optics
GA CR0TP
UT WOS:000361036400037
PM 26367913
ER
PT J
AU Sadler, JM
Toulan, FR
Palmese, GR
La Scala, JJ
AF Sadler, Joshua M.
Toulan, Faye R.
Palmese, Giuseppe R.
La Scala, John J.
TI Unsaturated polyester resins for thermoset applications using renewable
isosorbide as a component for property improvement
SO JOURNAL OF APPLIED POLYMER SCIENCE
LA English
DT Article
DE biopolymers and renewable polymers; polyesters; resins; thermosets
ID INFRARED-SPECTROSCOPY; VINYL-ESTER; CURE KINETICS; COPOLYMERIZATION;
NETWORKS; ACID
AB Unsaturated polyester (UPE) resins are used in a variety of thermosetting applications due to the reduced cost when compared to epoxy resins; however, UPE resins also have reduced thermomechanical performance. Investigating avenues to improve the performance of UPEs has led to the use of bio-based starting materials as structural components of the synthesized prepolymers as a result of their advantageous structural features. Isosorbide, a compound derived from renewable feedstocks, has been utilized to provide additional stiffness from the diol component for novel unsaturated polyesters resins. These resins have been shown to possess T-g's (32-72 degrees C) and storage moduli (540-2200 MPa) that are in the desired range for composite materials with viscosities (1.2-25 Pa s) amenable to a variety of liquid molding techniques. (c) 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 42315.
C1 [Sadler, Joshua M.; Toulan, Faye R.; La Scala, John J.] Army Res Lab, Coatings Corros & Engn Polymers Branch, RDRL WMM C, Aberdeen Proving Ground, MD 21005 USA.
[Palmese, Giuseppe R.] Drexel Univ, Dept Chem & Biol Engn, Philadelphia, PA 19104 USA.
RP La Scala, JJ (reprint author), Army Res Lab, Coatings Corros & Engn Polymers Branch, RDRL WMM C, Aberdeen Proving Ground, MD 21005 USA.
EM john.j.lascala.civ@mail.mil
FU U.S. Department of Defense, through the Strategic Environmental Research
and Development Program [SERDP WP-1758]; Environmental Quality Basic
Research Development Program; Postgraduate Research Participation
Program at the U.S. Army Research Laboratory; TCK Global; U.S. Army
Research Laboratory
FX This research was supported by the U.S. Department of Defense, through
the Strategic Environmental Research and Development Program (SERDP
WP-1758) and the Environmental Quality Basic Research Development
Program administered by the Armaments Research and Development
Engineering Command. This research was also supported in part by an
appointment to the Postgraduate Research Participation Program at the
U.S. Army Research Laboratory administered by the Oak Ridge Institute
for Science and Education through an interagency agreement between the
U.S. Department of Energy and USARL. This research was supported in part
by an interagency agreement between TCK Global and U.S. Army Research
Laboratory.
NR 44
TC 2
Z9 2
U1 7
U2 61
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-8995
EI 1097-4628
J9 J APPL POLYM SCI
JI J. Appl. Polym. Sci.
PD AUG 10
PY 2015
VL 132
IS 30
AR 42315
DI 10.1002/app.42315
PG 11
WC Polymer Science
SC Polymer Science
GA CH9RD
UT WOS:000354372800017
ER
PT J
AU Adamo, SH
Cain, MS
Mitroff, SR
AF Adamo, Stephen H.
Cain, Matthew S.
Mitroff, Stephen R.
TI Satisfaction at last: Evidence for the "satisfaction" hypothesis for
multiple-target search errors
SO VISUAL COGNITION
LA English
DT Article
DE Visual Search; Vigilance; Attention; Subsequent Search Misses;
Satisfaction
ID VISUAL-SEARCH
AB Multiple-target visual searches are susceptible to Subsequent Search Miss (SSM) errorsa reduced accuracy for target detection after a previous target has already been detected. SSM errors occur in critical searches (e.g., evaluations of radiographs and airport luggage x-rays), and have proven to be a stubborn problem. A few SSM theories have been offered, and here we investigate the satisfaction account: failing to completely finish a search after having found a first target. Accuracy on a multiple-target search task was compared to both how long participants spent searching after finding a first target and their target sensitivity in a separate vigilance task. Less time spent searching and poor vigilance predicted higher SSM error rates. These results suggest that observers who are more likely to miss a second target are less likely to thoroughly search after finding a first target, thus offering some of the first evidence for the satisfaction account.
C1 [Adamo, Stephen H.; Mitroff, Stephen R.] Duke Univ, Ctr Cognit Neurosci, Dept Psychol & Neurosci, Durham, NC 27708 USA.
[Cain, Matthew S.] US Army, Natick Soldier Res Dev & Engn Ctr, Natick, MA 01760 USA.
[Mitroff, Stephen R.] George Washington Univ, Dept Psychol, Washington, DC 20052 USA.
RP Adamo, SH (reprint author), Duke Univ, Ctr Cognit Neurosci, Dept Psychol & Neurosci, Durham, NC 27708 USA.
EM sha10@duke.edu
NR 7
TC 0
Z9 0
U1 1
U2 3
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 1350-6285
EI 1464-0716
J9 VIS COGN
JI Vis. Cogn.
PD AUG 9
PY 2015
VL 23
IS 7
BP 821
EP 825
DI 10.1080/13506285.2015.1093248
PG 5
WC Psychology, Experimental
SC Psychology
GA CW4OX
UT WOS:000364972100005
ER
PT J
AU Corron, NJ
Blakely, JN
AF Corron, Ned J.
Blakely, Jonathan N.
TI Chaos in optimal communication waveforms
SO PROCEEDINGS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING
SCIENCES
LA English
DT Article
DE communications theory; matched filter; chaos theory
ID SYSTEMS; ORIGINS
AB The properties of nonlinear dynamics and chaos are shown to be fundamental to optimal communication signals subject to two practical and realistic design requirements: (i) operation in a noisy environment and (ii) simple hardware implementation. Starting with a simple electronic circuit, a linear filter receiver is presumed, and the matched optimal communication waveform that maximizes the receiver signal-to-noise performance is derived. A return map using samples from this optimal waveform is conjugate to a shift, thereby implying the waveform is chaotic. The optimal communication waveform for a second simple receiver is similarly derived, and it is found to be an exact solution to a physically realizable chaotic oscillator. Thus, a practical consequence of chaos in these waveforms is the potential for simple and efficient signal generation using chaotic oscillators. A conjecture is made that the optimal communication waveform for any stable infinite impulse response filter is similarly chaotic.
C1 [Corron, Ned J.; Blakely, Jonathan N.] US Army, RDECOM, Charles M Bowden Lab, Aviat & Missile Res Dev & Engn Ctr, Redstone Arsenal, AL 35898 USA.
RP Corron, NJ (reprint author), US Army, RDECOM, Charles M Bowden Lab, Aviat & Missile Res Dev & Engn Ctr, Redstone Arsenal, AL 35898 USA.
EM ned.j.corron.civ@mail.mil
OI Corron, Ned/0000-0002-3232-5024
NR 23
TC 3
Z9 3
U1 0
U2 3
PU ROYAL SOC
PI LONDON
PA 6-9 CARLTON HOUSE TERRACE, LONDON SW1Y 5AG, ENGLAND
SN 1364-5021
EI 1471-2946
J9 P ROY SOC A-MATH PHY
JI Proc. R. Soc. A-Math. Phys. Eng. Sci.
PD AUG 8
PY 2015
VL 471
IS 2180
AR 20150222
DI 10.1098/rspa.2015.0222
PG 9
WC Multidisciplinary Sciences
SC Science & Technology - Other Topics
GA CU4FA
UT WOS:000363481300019
ER
PT J
AU Gust, KA
Nanduri, B
Rawat, A
Wilbanks, MS
Ang, CY
Johnson, DR
Pendarvis, K
Chen, XF
Quinn, MJ
Johnson, MS
Burgess, SC
Perkins, EJ
AF Gust, Kurt A.
Nanduri, Bindu
Rawat, Arun
Wilbanks, Mitchell S.
Ang, Choo Yaw
Johnson, David R.
Pendarvis, Ken
Chen, Xianfeng
Quinn, Michael J., Jr.
Johnson, Mark S.
Burgess, Shane C.
Perkins, Edward J.
TI Systems toxicology identifies mechanistic impacts of
2-amino-4,6-dinitrotoluene (2A-DNT) exposure in Northern Bobwhite
SO BMC GENOMICS
LA English
DT Article
DE Transcriptomics; Proteomics; Systems toxicology; Nitrotoluenes; Northern
Bobwhite; PPAR signaling
ID PROLIFERATOR-ACTIVATED RECEPTORS; COLINUS-VIRGINIANUS;
CELL-PROLIFERATION; GENE-EXPRESSION; MICROARRAY DATA; MESSENGER-RNA;
PROTEIN; RDX; 1,3,5-TRINITRO-1,3,5-TRIAZINE; 2,6-DINITROTOLUENE
AB Background: A systems toxicology investigation comparing and integrating transcriptomic and proteomic results was conducted to develop holistic effects characterizations for the wildlife bird model, Northern bobwhite (Colinus virginianus) dosed with the explosives degradation product 2-amino-4,6-dinitrotoluene (2A-DNT). A subchronic 60d toxicology bioassay was leveraged where both sexes were dosed via daily gavage with 0, 3, 14, or 30 mg/kg-d 2A-DNT. Effects on global transcript expression were investigated in liver and kidney tissue using custom microarrays for C. virginianus in both sexes at all doses, while effects on proteome expression were investigated in liver for both sexes and kidney in males, at 30 mg/kg-d.
Results: As expected, transcript expression was not directly indicative of protein expression in response to 2A-DNT. However, a high degree of correspondence was observed among gene and protein expression when investigating higher-order functional responses including statistically enriched gene networks and canonical pathways, especially when connected to toxicological outcomes of 2A-DNT exposure. Analysis of networks statistically enriched for both transcripts and proteins demonstrated common responses including inhibition of programmed cell death and arrest of cell cycle in liver tissues at 2A-DNT doses that caused liver necrosis and death in females. Additionally, both transcript and protein expression in liver tissue was indicative of induced phase I and II xenobiotic metabolism potentially as a mechanism to detoxify and excrete 2A-DNT. Nuclear signaling assays, transcript expression and protein expression each implicated peroxisome proliferator-activated receptor (PPAR) nuclear signaling as a primary molecular target in the 2A-DNT exposure with significant downstream enrichment of PPAR-regulated pathways including lipid metabolic pathways and gluconeogenesis suggesting impaired bioenergetic potential.
Conclusion: Although the differential expression of transcripts and proteins was largely unique, the consensus of functional pathways and gene networks enriched among transcriptomic and proteomic datasets provided the identification of many critical metabolic functions underlying 2A-DNT toxicity as well as impaired PPAR signaling, a key molecular initiating event known to be affected in di- and trinitrotoluene exposures.
C1 [Gust, Kurt A.; Wilbanks, Mitchell S.; Perkins, Edward J.] US Army, Engineer Res & Dev, Environm Lab, EL EP P, Vicksburg, MS 39180 USA.
[Nanduri, Bindu] Mississippi State Univ, Inst Digital Biol, Starkville, MS 39762 USA.
[Rawat, Arun] Translat Genom Res Inst, Phoenix, AZ 85004 USA.
[Ang, Choo Yaw] Badger Tech Serv, San Antonio, TX 78216 USA.
[Johnson, David R.] Conestoga Rovers & Associates, Dallas, TX 75234 USA.
[Pendarvis, Ken] Univ Arizona, Sch Anim & Comparat Biomed Sci, Tucson, AZ 85721 USA.
[Pendarvis, Ken] Univ Arizona, Inst Bio5, Tucson, AZ 85721 USA.
[Chen, Xianfeng] IFXworks LLC, Arlington, VA 22204 USA.
[Quinn, Michael J., Jr.; Johnson, Mark S.] US Army, Publ Hlth Command, Aberdeen, MD 21010 USA.
[Burgess, Shane C.] Univ Arizona, Coll Agr & Life Sci, Tucson, AZ 85721 USA.
RP Gust, KA (reprint author), US Army, Engineer Res & Dev, Environm Lab, EL EP P, 3909 Halls Ferry Rd, Vicksburg, MS 39180 USA.
EM kurt.a.gust@usace.army.mil
OI Rawat, Arun/0000-0003-0540-2044
FU US Army Environmental Quality Technology Research Program
FX We acknowledge Allen Shack and Leslie B Shack for supporting the
proteomics efforts in this study. This work was supported by the US Army
Environmental Quality Technology Research Program. Permission was
granted by the Chief of Engineers to publish this information. The views
and opinions expressed in this paper are those of the individual authors
and not those of the U.S. Army, or other sponsor organizations.
NR 43
TC 1
Z9 1
U1 1
U2 9
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2164
J9 BMC GENOMICS
JI BMC Genomics
PD AUG 7
PY 2015
VL 16
AR 587
DI 10.1186/s12864-015-1798-4
PG 17
WC Biotechnology & Applied Microbiology; Genetics & Heredity
SC Biotechnology & Applied Microbiology; Genetics & Heredity
GA CO4DR
UT WOS:000359111300001
PM 26251320
ER
PT J
AU Frevert, U
Krzych, U
Richie, TL
AF Frevert, Ute
Krzych, Urszula
Richie, Thomas L.
TI Editorial: Breaking the cycle: attacking the malaria parasite in the
liver
SO FRONTIERS IN MICROBIOLOGY
LA English
DT Editorial Material
DE Plasmodium; immunity; antigen-presenting cell; B cell; CD8 T cell; CD4 T
cell; vaccine; adjuvant
ID MODEL
C1 [Frevert, Ute] NYU, Sch Med, Dept Microbiol, Div Med Parasitol, New York, NY 10016 USA.
[Krzych, Urszula] Walter Reed Army Inst Res, Cellular Immunol, Silver Spring, MD USA.
[Richie, Thomas L.] Sanaria Inc, Rockville, MD USA.
RP Frevert, U (reprint author), NYU, Sch Med, Dept Microbiol, Div Med Parasitol, New York, NY 10016 USA.
EM ute.frevert@nyumc.org; urszula.krzych1.civ@mail.mil; trichie@sanaria.com
OI Richie, Thomas/0000-0002-2946-5456
NR 18
TC 2
Z9 2
U1 1
U2 8
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015,
SWITZERLAND
SN 1664-302X
J9 FRONT MICROBIOL
JI Front. Microbiol.
PD AUG 7
PY 2015
VL 6
AR 810
DI 10.3389/fmicb.2015.00810
PG 3
WC Microbiology
SC Microbiology
GA CO9HU
UT WOS:000359486400001
PM 26300873
ER
PT J
AU Ernat, JJ
Song, DJ
Brugman, SC
Shaha, SH
Tokish, JM
Lee, GY
AF Ernat, J. J.
Song, D. J.
Brugman, S. C.
Shaha, S. H.
Tokish, J. M.
Lee, G. Y.
TI Mental Health Medication Use Correlates with Poor Outcome After
Femoroacetabular Impingement Surgery in a Military Population
SO JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
LA English
DT Article
ID PSYCHOLOGICAL DISTRESS; IRAQ; AFGHANISTAN; PREVALENCE; SOLDIERS;
PATIENT; COMBAT; DUTY
AB Background: Femoroacetabular impingement is a common cause of hip pain in young adults. Several preoperative risk factors for poor outcomes with surgery have been identified; however, to our knowledge, no study has attempted to determine the effect of psychiatric comorbidity on outcomes with femoroacetabular impingement surgery.
Methods: A retrospective review was performed on active-duty patients at one institution undergoing surgery for femoroacetabular impingement over five years. Medical records were reviewed for demographic characteristics, radiographic data, and history of mental health medication use. Return-to-duty status was considered the primary outcome measure. Outcome scores obtained included modified Harris hip scores, Single Assessment Numeric Evaluation scores, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores, patient satisfaction, and Veterans RAND-12 scores. Patients taking mental health medication were compared with those who were not with regard to return to duty and validated patient-reported outcome measures.
Results: Ninety-three patients (mean age, 32.2 years) were available for follow-up at a mean duration of 3.6 years. Of the seventeen patients discharged from service postoperatively, twelve (71%) were taking mental health medications. One-third (twenty-five) of seventy-six patients who returned to duty were taking mental health medication and this difference was significant (p < 0.006). Patients taking mental health medication had significantly poorer modified Harris hip scores (p < 0.02), WOMAC scores (p < 0.0008), and Veterans RAND-12 mental scores (p < 0.001). Antidepressant, antipsychotic, and multiple mental health medication use were all predictive of medical discharge due to hip pain.
Conclusions: Psychiatric comorbidities are an important risk factor in active-duty military personnel undergoing surgery for femoroacetabular impingement. Mental health medication use is associated with poorer outcome scores and can significantly lower the possibility of returning to active-duty status.
C1 [Ernat, J. J.; Song, D. J.; Brugman, S. C.; Shaha, S. H.; Tokish, J. M.; Lee, G. Y.] Tripler Army Med Ctr, Honolulu, HI 96859 USA.
RP Ernat, JJ (reprint author), Tripler Army Med Ctr, 1 Jarrett White Rd, Honolulu, HI 96859 USA.
EM jtokish@ghs.org
NR 28
TC 2
Z9 2
U1 0
U2 0
PU JOURNAL BONE JOINT SURGERY INC
PI NEEDHAM
PA 20 PICKERING ST, NEEDHAM, MA 02192 USA
SN 0021-9355
EI 1535-1386
J9 J BONE JOINT SURG AM
JI J. Bone Joint Surg.-Am. Vol.
PD AUG 5
PY 2015
VL 97A
IS 15
BP 1272
EP 1277
DI 10.2106/JBJS.O.00043
PG 6
WC Orthopedics; Surgery
SC Orthopedics; Surgery
GA CY4RS
UT WOS:000366396500010
PM 26246262
ER
PT J
AU Marathe, AR
Ries, AJ
Lawhern, VJ
Lance, BJ
Touryan, J
McDowell, K
Cecotti, H
AF Marathe, Amar R.
Ries, Anthony J.
Lawhern, Vernon J.
Lance, Brent J.
Touryan, Jonathan
McDowell, Kaleb
Cecotti, Hubert
TI The effect of target and non-target similarity on neural classification
performance: a boost from confidence
SO FRONTIERS IN NEUROSCIENCE
LA English
DT Article
DE confidence; EEG; classification; single-trial analysis; rapid serial
visual presentation; brain-computer interface
ID SERIAL VISUAL PRESENTATION; COUPLED COMPUTER VISION; FALSE DISCOVERY
RATE; TASK; BLINK
AB Brain computer interaction (BCI) technologies have proven effective in utilizing single-trial classification algorithms to detect target images in rapid serial visualization presentation tasks. While many factors contribute to the accuracy of these algorithms, a critical aspect that is often overlooked concerns the feature similarity between target and non-target images. In most real-world environments there are likely to be many shared features between targets and non-targets resulting in similar neural activity between the two classes. It is unknown how current neural-based target classification algorithms perform when qualitatively similar target and non-target images are presented. This study address this question by comparing behavioral and neural classification performance across two conditions: first, when targets were the only infrequent stimulus presented amongst frequent background distracters; and second when targets were presented together with infrequent non-targets containing similar visual features to the targets. The resulting findings show that behavior is slower and less accurate when targets are presented together with similar non-targets; moreover, single-trial classification yielded high levels of misclassification when infrequent non-targets are included. Furthermore, we present an approach to mitigate the image misclassification. We use confidence measures to assess the quality of single-trial classification, and demonstrate that a system in which low confidence trials are reclassified through a secondary process can result in improved performance.
C1 [Marathe, Amar R.; Ries, Anthony J.; Lawhern, Vernon J.; Lance, Brent J.; Touryan, Jonathan; McDowell, Kaleb] US Army Res Lab, Human Res & Engn Directorate, Translat Neurosci Branch, Aberdeen Proving Ground, MD 21005 USA.
[Lawhern, Vernon J.] Univ Texas San Antonio, Dept Comp Sci, San Antonio, TX USA.
[Cecotti, Hubert] Univ Ulster, Sch Comp & Intelligent Syst, Intelligent Syst Res Ctr, Coleraine, Londonderry, North Ireland.
RP Marathe, AR (reprint author), US Army Res Lab, Human Res & Engn Directorate, Translat Neurosci Branch, 459 Mulberry Point Rd, Aberdeen Proving Ground, MD 21005 USA.
EM amar.marathe@case.edu
FU U.S. Army Research Laboratory [FY14-FY16]; Office of the Secretary of
Defense ARPI program [MIPR DWAM31168]; Institute for Collaborative
Biotechnologies from the U.S. Army Research Office [W911NF-09-D-0001]
FX This project was supported by The U.S. Army Research Laboratory under a
Director's Strategic Research Initiative entitled "Heterogeneous Systems
for Information Variable Environments (HIVE)" from FY14-FY16, the Office
of the Secretary of Defense ARPI program MIPR DWAM31168, the Institute
for Collaborative Biotechnologies through contract W911NF-09-D-0001 from
the U.S. Army Research Office, and an appointment to the U.S. Army
Research Laboratory Postdoctoral Fellowship program administered by the
Oak Ridge Associated Universities through a cooperative agreement with
the U.S. Army Research Laboratory. The authors would like to thank W.
David Hairston for substantial effort in experimental setup and
execution.
NR 42
TC 6
Z9 6
U1 1
U2 4
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015,
SWITZERLAND
SN 1662-453X
J9 FRONT NEUROSCI-SWITZ
JI Front. Neurosci.
PD AUG 5
PY 2015
VL 9
AR 270
DI 10.3389/fnins.2015.00270
PG 11
WC Neurosciences
SC Neurosciences & Neurology
GA CS5NY
UT WOS:000362126200002
PM 26347597
ER
PT J
AU Saxena, A
Hastings, NB
Sun, W
Dabisch, PA
Hulet, SW
Jakubowski, EM
Mioduszewski, RJ
Doctor, BP
AF Saxena, Ashima
Hastings, Nicholas B.
Sun, Wei
Dabisch, Paul A.
Hulet, Stanley W.
Jakubowski, Edward M.
Mioduszewski, Robert J.
Doctor, Bhupendra P.
TI Prophylaxis with human serum butyrylcholinesterase protects Gottingen
minipigs exposed to a lethal high-dose of sarin vapor
SO CHEMICO-BIOLOGICAL INTERACTIONS
LA English
DT Article
DE Human serum butyrylcholinesterase; Minipig; Sarin vapor; High-dose
exposure; Cardiotoxicity
ID NERVE AGENT TOXICITY; GUINEA-PIGS; ACETYLCHOLINESTERASE ACTIVITY; ACUTE
ORGANOPHOSPHATE; SOMAN; PRETREATMENT; PROLONGATION; RATS; MICE; VX
AB Serum-derived human butyrylcholinesterase (Hu BChE) is a stoichiometric bioscavenger that is being developed as a potential prophylactic nerve agent countermeasure. Previously, we reported the prophylactic efficacy of Hu BChE in Gottingen minipigs against a whole-body exposure to 4.1 mg/m(3) of sarin (GB) vapor, which produced lethality over 60 min. Since the toxicity of nerve agent is concentration-dependent, in the present study, we investigated the toxic effects of an almost 3-fold higher rate of GB vapor exposure and the ability of Hu BChE to protect minipigs against this exposure. Male minipigs were subjected to: (1) air exposure; (2) GB vapor exposure; or (3) pretreatment with 7.5 mg/kg of Hu BChE by i.m. injection, 24 h prior to whole-body exposure to 11.4 mg/m(3) of GB vapor for 10 min. Electrocardiogram, electroencephalogram, and pupil size were monitored throughout exposure. Blood drawn before and throughout exposure was analyzed for blood gases, electrolytes, metabolites, acetylcholinesterase and BChE activities, and amount of GB bound to red blood cells and plasma. A novel finding was that saline-treated animals exposed to GB vapor did not develop any seizures, but manifested a variety of cardiac and whole blood toxic signs and rapidly died due to respiratory failure. Strikingly, pre-treatment with 7.5 mg/kg of Hu BChE not only prevented lethality, but also avoided all cardiac toxic signs manifested in the non-treated cohort. Thus, Hu BChE alone can serve as an effective prophylactic countermeasure versus a lethal high-dose exposure to GB vapor. Published by Elsevier Ireland Ltd.
C1 [Saxena, Ashima; Hastings, Nicholas B.; Sun, Wei; Doctor, Bhupendra P.] Walter Reed Army Inst Res, Div Biochem, Silver Spring, MD 20910 USA.
[Dabisch, Paul A.; Hulet, Stanley W.; Jakubowski, Edward M.; Mioduszewski, Robert J.] Edgewood Chem Biol Ctr, Operat Toxicol Team, Aberdeen Proving Ground, MD 21010 USA.
RP Saxena, A (reprint author), Walter Reed Army Inst Res, US Mil HIV Res Program, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM Ashima.saxena.civ@mail.mil
FU Defense Threat Reduction Agency
FX The opinions or assertions contained herein are the private views of the
authors and are not to be construed as official or as reflecting the
views of the Army or the Department of Defense. The authors wish to
thank Ms. Amy Michels for her assistance in preparation of the
manuscript. This research was supported by funding from the Defense
Threat Reduction Agency.
NR 41
TC 5
Z9 5
U1 1
U2 16
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
IRELAND
SN 0009-2797
EI 1872-7786
J9 CHEM-BIOL INTERACT
JI Chem.-Biol. Interact.
PD AUG 5
PY 2015
VL 238
BP 161
EP 169
DI 10.1016/j.cbi.2015.07.001
PG 9
WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
GA CP5WZ
UT WOS:000359957400020
PM 26145887
ER
PT J
AU Steenkamp, MM
Litz, BT
Hoge, CW
Marmar, CR
AF Steenkamp, Maria M.
Litz, Brett T.
Hoge, Charles W.
Marmar, Charles R.
TI Psychotherapy for Military-Related PTSD A Review of Randomized Clinical
Trials
SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
LA English
DT Review
ID POSTTRAUMATIC-STRESS-DISORDER; EYE-MOVEMENT DESENSITIZATION; COGNITIVE
PROCESSING THERAPY; REALITY EXPOSURE THERAPY; VIETNAM COMBAT VETERANS;
WAR VETERANS; HEALTH-CARE; BEHAVIORAL THERAPY; SELF-MANAGEMENT; SYMPTOMS
AB IMPORTANCE Posttraumatic stress disorder (PTSD) is a disabling psychiatric disorder common among military personnel and veterans. First-line psychotherapies most often recommended for PTSD consist mainly of "trauma-focused" psychotherapies that involve focusing on details of the trauma or associated cognitive and emotional effects.
OBJECTIVE To examine the effectiveness of psychotherapies for PTSD in military and veteran populations.
EVIDENCE REVIEW PubMed, PsycINFO, and PILOTS were searched for randomized clinical trials (RCTs) of individual and group psychotherapies for PTSD in military personnel and veterans, published from January 1980 to March 1, 2015. We also searched reference lists of articles, selected reviews, and meta-analyses. Of 891 publications initially identified, 36 were included.
FINDINGS Two trauma-focused therapies, cognitive processing therapy (CPT) and prolonged exposure, have been the most frequently studied psychotherapies for military-related PTSD. Five RCTs of CPT (that included 481 patients) and 4 RCTs of prolonged exposure (that included 402 patients) met inclusion criteria. Focusing on intent-to-treat outcomes, within-group posttreatment effect sizes for CPT and prolonged exposure were large (Cohen d range, 0.78-1.10). CPT and prolonged exposure also outperformed waitlist and treatment-as-usual control conditions. Forty-nine percent to 70% of participants receiving CPT and prolonged exposure attained clinically meaningful symptom improvement (defined as a 10- to 12-point decrease in interviewer-assessed or self-reported symptoms). However, mean posttreatment scores for CPT and prolonged exposure remained at or above clinical criteria for PTSD, and approximately two-thirds of patients receiving CPT or prolonged exposure retained their PTSD diagnosis after treatment (range, 60%-72%). CPT and prolonged exposure were marginally superior compared with non-trauma-focused psychotherapy comparison conditions.
CONCLUSIONS AND RELEVANCE In military and veteran populations, trials of the first-line trauma-focused interventions CPT and prolonged exposure have shown clinically meaningful improvements for many patients with PTSD. However, nonresponse rates have been high, many patients continue to have symptoms, and trauma-focused interventions show marginally superior results compared with active control conditions. There is a need for improvement in existing PTSD treatments and for development and testing of novel evidence-based treatments, both trauma-focused and non-trauma-focused.
C1 [Steenkamp, Maria M.; Marmar, Charles R.] NYU, Langone Sch Med, Steven & Alexandra Cohen Vet Ctr Posttraumat Stre, New York, NY 10016 USA.
[Litz, Brett T.] Boston Univ, Sch Med, VA Boston Healthcare Syst, Massachusetts Vet Epidemiol Res & Informat Ctr MA, Boston, MA 02118 USA.
[Hoge, Charles W.] Walter Reed Army Inst Res, Silver Spring, MD USA.
RP Steenkamp, MM (reprint author), NYU, Langone Sch Med, Steven & Alexandra Cohen Vet Ctr Posttraumat Stre, One Pk Ave,Room 8-107, New York, NY 10016 USA.
EM maria.steenkamp@nyumc.org
NR 80
TC 37
Z9 37
U1 4
U2 39
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 0098-7484
EI 1538-3598
J9 JAMA-J AM MED ASSOC
JI JAMA-J. Am. Med. Assoc.
PD AUG 4
PY 2015
VL 314
IS 5
BP 489
EP 500
DI 10.1001/jama.2015.8370
PG 12
WC Medicine, General & Internal
SC General & Internal Medicine
GA CO1OI
UT WOS:000358924500013
PM 26241600
ER
PT J
AU Dubick, MA
Pusateri, AE
AF Dubick, Michael A.
Pusateri, Anthony E.
TI WHAT'S NEW IN SHOCK, MILITARY SUPPLEMENT 2015?
SO SHOCK
LA English
DT Editorial Material
C1 [Dubick, Michael A.] JBSA, US Army Inst Surg Res, Ft Sam Houston, TX 78234 USA.
[Pusateri, Anthony E.] US Army Med Res Mat Command, Combat Casualty Care Res Program, Ft Detrick, MD USA.
RP Dubick, MA (reprint author), JBSA, US Army Inst Surg Res, Ft Sam Houston, TX 78234 USA.
NR 20
TC 0
Z9 0
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1073-2322
EI 1540-0514
J9 SHOCK
JI Shock
PD AUG
PY 2015
VL 44
SU 1
BP 1
EP 2
PG 2
WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease
SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System
& Cardiology
GA DO3NA
UT WOS:000377687100001
PM 26177015
ER
PT J
AU Pusateri, AE
Dubick, MA
AF Pusateri, Anthony E.
Dubick, Michael A.
TI THE US DEPARTMENT OF DEFENSE HEMORRHAGE AND RESUSCITATION RESEARCH AND
DEVELOPMENT PROGRAM
SO SHOCK
LA English
DT Article
DE Hemorrhage; Resuscitation; Department of Defense
ID COMBAT CASUALTY CARE
AB Data from recent conflicts demonstrate the continuing need for research and development focusing on hemorrhage control, fluid resuscitation, blood products, transfusion, and pathophysiologic responses to traumatic hemorrhage. The US Department of Defense Hemorrhage and Resuscitation Research and Development Program brings together US Department of Defense efforts and is coordinated with efforts of our other federal government, industry, international, and university-based partners. Military medical research has led to advances in both military and civilian trauma care. A sustained effort will be required to continue to advance the care of severely injured trauma patients.
C1 [Pusateri, Anthony E.] US Army Med Res Mat Command, Combat Casualty Care Res Program, 504 Scott St,Bldg 722, Ft Detrick, MD 21702 USA.
[Dubick, Michael A.] JBSA Ft Sam Houston, US Army Inst Surg Res, San Antonio, TX USA.
RP Pusateri, AE (reprint author), US Army Med Res Mat Command, Combat Casualty Care Res Program, 504 Scott St,Bldg 722, Ft Detrick, MD 21702 USA.
EM anthony.e.pusateri.civ@mail.mil
NR 9
TC 0
Z9 0
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1073-2322
EI 1540-0514
J9 SHOCK
JI Shock
PD AUG
PY 2015
VL 44
SU 1
BP 3
EP 5
DI 10.1097/SHK.0000000000000424
PG 3
WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease
SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System
& Cardiology
GA DO3NA
UT WOS:000377687100002
PM 26177016
ER
PT J
AU Tortella, FC
Leung, LY
AF Tortella, Frank C.
Leung, Lai Yee
TI TRAUMATIC BRAIN INJURY AND POLYTRAUMA IN THEATERS OF COMBAT: THE CASE
FOR NEUROTRAUMA RESUSCITATION?
SO SHOCK
LA English
DT Review
DE Traumatic brain injury; polytrauma; prehospital; fluid resuscitation;
neurotherapeutics
ID CLOSED-HEAD INJURY; ACTIVATED FACTOR-VII; HYPERTONIC SALINE
RESUSCITATION; DAMAGE CONTROL RESUSCITATION; RANDOMIZED
CONTROLLED-TRIAL; CEREBRAL-BLOOD-FLOW; HEMORRHAGIC-SHOCK; FLUID
RESUSCITATION; INTRACRANIAL-PRESSURE; HYPOXIA-HYPOTENSION
AB Polytrauma associated with traumatic brain injury (TBI) is defined as a concurrent injury to the brain and one or more body areas or organ systems that results in physical, cognitive, and psychosocial impairments. Consequently, polytrauma accompanied by TBI presents a unique challenge for emergency medicine, in particular, to those associated with the austere environments encountered in military theaters of operation and the logistics of en-route care. Here, we attempt to put needed focus on this medical emergency, specifically addressing the problem of an exsanguinating polytrauma requiring fluid resuscitation complicated by TBI. Critical questions to consider are the following: (1) What is the optimal resuscitation fluid for these patients? (2) In defining the resuscitation fluid, what considerations must be given with regard to the very specific logistics of military operations? and (3) Can treatment of the brain injury be initiated in parallel with resuscitation practices. Recognizing the immense clinical and experimental complexity of this problem, our goal was to encourage research that embraces with high-fidelity 'combined' animal models of polytrauma and TBI with an objective toward elucidating safe and effective neurotherapeutic resuscitation protocols.
C1 [Tortella, Frank C.; Leung, Lai Yee] Walter Reed Army Inst Res, Brain Trauma Neuroprotect & Neurorestorat Branch, Ctr Mil Psychiat & Neurosci, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
RP Leung, LY (reprint author), Walter Reed Army Inst Res, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
EM laiyee.leung.ctr@mail.mil
NR 109
TC 5
Z9 5
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1073-2322
EI 1540-0514
J9 SHOCK
JI Shock
PD AUG
PY 2015
VL 44
SU 1
BP 17
EP 26
DI 10.1097/SHK.0000000000000380
PG 10
WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease
SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System
& Cardiology
GA DO3NA
UT WOS:000377687100004
PM 25895144
ER
PT J
AU Convertino, VA
Howard, JT
Hinojosa-Laborde, C
Cardin, S
Batchelder, P
Mulligan, J
Grudic, GZ
Moulton, SL
MacLeod, DB
AF Convertino, Victor A.
Howard, Jeffrey T.
Hinojosa-Laborde, Carmen
Cardin, Sylvain
Batchelder, Paul
Mulligan, Jane
Grudic, Gregory Z.
Moulton, Steven L.
MacLeod, David B.
TI INDIVIDUAL-SPECIFIC, BEAT-TO-BEAT TRENDING OF SIGNIFICANT HUMAN BLOOD
LOSS: THE COMPENSATORY RESERVE
SO SHOCK
LA English
DT Article
DE Compensatory reserve; prehospital; triage; hemorrhage; blood loss;
hypovolemia
ID COMBAT CASUALTY CARE; HEART PERIOD VARIABILITY; BODY NEGATIVE-PRESSURE;
ARTERIAL WAVE-FORMS; CENTRAL HYPOVOLEMIA; STROKE VOLUME; LIFESAVING
INTERVENTIONS; SIMULATED HEMORRHAGE; TRAUMA PATIENTS; PULSE PRESSURE
AB Current monitoring technologies are unable to detect early, compensatory changes that are associated with significant blood loss. We previously introduced a novel algorithm to calculate the Compensatory Reserve Index (CRI) based on the analysis of arterial waveform features obtained from photoplethysmogram recordings. In the present study, we hypothesized that the CRI would provide greater sensitivity and specificity to detect blood loss compared with traditional vital signs and other hemodynamic measures. Continuous noninvasive vital sign waveform data, including CRI, photoplethysmogram, heart rate, blood pressures, SpO(2), cardiac output, and stroke volume, were analyzed from 20 subjects before, during, and after an average controlled voluntary hemorrhage of similar to 1.2 L of blood. Compensatory Reserve Index decreased by 33% in a linear fashion across progressive blood volume loss, with no clinically significant alterations in vital signs. The receiver operating characteristic area under the curve for the CRI was 0.90, with a sensitivity of 0.80 and specificity of 0.76. In comparison, blood pressures, heart rate, SpO(2), cardiac output, and stroke volume had significantly lower receiver operating characteristic area under the curve values and specificities for detecting the same volume of blood loss. Consistent with our hypothesis, CRI detected blood loss and restoration with significantly greater specificity than did other traditional physiologic measures. Single measurement of CRI may enable more accurate triage, whereas CRI monitoring may allow for earlier detection of casualty deterioration.
C1 [Convertino, Victor A.; Howard, Jeffrey T.; Hinojosa-Laborde, Carmen] JBSA Ft Sam Houston, US Army Inst Surg Res, Ft Sam Houston, TX 78234 USA.
[Cardin, Sylvain] Med Res & Mat Command, Ft Detrick, MD USA.
[Batchelder, Paul] CliniMark, Denver, CO USA.
[Mulligan, Jane; Grudic, Gregory Z.; Moulton, Steven L.] Flashback Technol Inc, Boulder, CO USA.
[Moulton, Steven L.] Univ Colorado, Aurora, CO USA.
[MacLeod, David B.] Duke Univ, Med Ctr, Human Pharmacol & Physiol, Durham, NC USA.
RP Convertino, VA (reprint author), JBSA Ft Sam Houston, US Army Inst Surg Res, Ft Sam Houston, TX 78234 USA.
EM victor.a.convertino.civ@mail.mil
FU US Army Medical Research and Materiel Command Combat Casualty Research
Program [W81XWH-09-1-0750, W81XWH-09-C-0160, W81XWH-11-2-0091,
W81XWH-11-2-0085, W81XWH-12-2-0112]; US Army Small Business Innovative
Research program; Oak Ridge Institute of Science and Education
FX This research was supported in part by funding from the US Army Medical
Research and Materiel Command Combat Casualty Research Program (under
grants W81XWH-09-1-0750, W81XWH-09-C-0160, W81XWH-11-2-0091,
W81XWH-11-2-0085, and W81XWH-12-2-0112) and the US Army Small Business
Innovative Research program. This study was also supported in part by a
postdoctoral fellowship provided by the Oak Ridge Institute of Science
and Education.
NR 25
TC 9
Z9 9
U1 1
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1073-2322
EI 1540-0514
J9 SHOCK
JI Shock
PD AUG
PY 2015
VL 44
SU 1
BP 27
EP 32
DI 10.1097/SHK.0000000000000323
PG 6
WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease
SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System
& Cardiology
GA DO3NA
UT WOS:000377687100005
PM 25565640
ER
PT J
AU White, NJ
Newton, JC
Martin, EJ
Mohammed, BM
Contaifer, D
Bostic, JL
Brophy, GM
Spiess, BD
Pusateri, AE
Ward, KR
Brophy, DF
AF White, Nathan J.
Newton, Jason C.
Martin, Erika J.
Mohammed, Bassem M.
Contaifer, Daniel, Jr.
Bostic, Jessica L.
Brophy, Gretchen M.
Spiess, Bruce D.
Pusateri, Anthony E.
Ward, Kevin R.
Brophy, Donald F.
TI CLOT FORMATION IS ASSOCIATED WITH FIBRINOGEN AND PLATELET FORCES IN A
COHORT OF SEVERELY INJURED EMERGENCY DEPARTMENT TRAUMA PATIENTS
SO SHOCK
LA English
DT Article
DE Trauma; coagulopathy; injury; bleeding
ID EARLY COAGULOPATHY; FACTOR-XIII; THROMBOCYTOPENIA; RESUSCITATION;
FIBRINOLYSIS; COAGULATION; REPLACEMENT; MORTALITY; DEATH
AB Introduction: Anticoagulation, fibrinogen consumption, fibrinolytic activation, and platelet dysfunction all interact to produce different clot formation responses after trauma. However, the relative contributions of these coagulation components to overall clot formation remain poorly defined. We examined for sources of heterogeneity in clot formation responses after trauma. Methods: Blood was sampled in the emergency department from patients meeting trauma team activation criteria at an urban trauma center. Plasma prothrombin time of 18 s or longer was used to define traumatic coagulopathy. Mean kaolin-activated thrombelastography (TEG) parameters were calculated and tested for heterogeneity using analysis of means. Discriminant analysis and forward stepwise variable selection with linear regression were used to determine if prothrombin time, fibrinogen, platelet contractile force (PCF), and D-dimer concentration, representing key mechanistic components of coagulopathy, each contribute to heterogeneous TEG responses after trauma. Results: Of 95 subjects, 16% met criteria for coagulopathy. Coagulopathic subjects were more severely injured with greater shock and received more blood products in the first 8 h compared with noncoagulopathic subjects. Mean (SD) TEG maximal amplitude (MA) was significantly decreased in the coagulopathic group (57.5 [SD, 4.7] mm vs. 62.7 [SD, 4.7], t test P < 0.001). The MA also exceeded the ANOM predicted upper decision limit for the noncoagulopathic group and the lower decision limit for the coagulopathic group at alpha = 0.05, suggesting significant heterogeneity from the overall cohort mean. Fibrinogen and PCF best discriminated TEG MA using discriminant analysis. Fibrinogen, PCF, and D-dimer were primary covariates for TEG MA using regression analysis. Conclusions: Heterogeneity in TEG-based clot formation in emergency department trauma patients was linked to changes in MA. Individual parameters representing fibrin polymerization, PCFs, and fibrinolysis were primarily associated with TEG MA after trauma and should be the focus of early hemostatic therapies.
C1 [White, Nathan J.] Univ Washington, Div Emergency Med, Seattle, WA 98195 USA.
[White, Nathan J.] Puget Sound Blood Ctr Res Inst, Seattle, WA USA.
[Newton, Jason C.; Martin, Erika J.; Mohammed, Bassem M.; Contaifer, Daniel, Jr.; Bostic, Jessica L.; Brophy, Donald F.] Virginia Commonwealth Univ, Coagulat Adv Lab, Dept Pharmacotherapy & Outcomes Sci, Richmond, VA USA.
[Mohammed, Bassem M.] Cairo Univ, Dept Clin Pharm, Fac Pharm, Cairo, Egypt.
[Brophy, Gretchen M.] Virginia Commonwealth Univ, Pharmacotherapy & Outcomes Sci, Richmond, VA USA.
[Brophy, Gretchen M.] Virginia Commonwealth Univ, Dept Neurosurg, Richmond, VA USA.
[Pusateri, Anthony E.] US Army Med Res & Mat Command, Ft Detrick, MD USA.
[Ward, Kevin R.] Univ Michigan, Michigan Ctr Integrat Res Crit Care, Ann Arbor, MI 48109 USA.
RP White, NJ (reprint author), Harborview Med Ctr, Div Emergency Med, Box 359702,329 9th Ave, Seattle, WA 98199 USA.
EM whiten4@uw.edu
FU US Defense Health Program; US Army Medical Research and Materiel Command
[W81XWH-11-2-0089]; National Center for Advancing Translational Sciences
(NCATS) of the National Institutes of Health (NIH) [KL2 TR000421]
FX This study was supported by the US Defense Health Program, US Army
Medical Research and Materiel Command grant W81XWH-11-2-0089. N.J.W. is
supported in part by the National Center for Advancing Translational
Sciences (NCATS) (grant KL2 TR000421), a component of the National
Institutes of Health (NIH).
NR 24
TC 1
Z9 1
U1 2
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1073-2322
EI 1540-0514
J9 SHOCK
JI Shock
PD AUG
PY 2015
VL 44
SU 1
BP 39
EP 44
DI 10.1097/SHK.0000000000000342
PG 6
WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease
SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System
& Cardiology
GA DO3NA
UT WOS:000377687100007
PM 25643013
ER
PT J
AU Hamilton, JA
Mora, AG
Chung, KK
Bebarta, VS
AF Hamilton, Joshua A.
Mora, Alejandra G.
Chung, Kevin K.
Bebarta, Vikhyat S.
TI IMPACT OF ANEMIA IN CRITICALLY ILL BURNED CASUALTIES EVACUATED FROM
COMBAT THEATER VIA US MILITARY CRITICAL CARE AIR TRANSPORT TEAMS
SO SHOCK
LA English
DT Article
DE Transfusion; en-route care; burns; military; critical care
ID OPERATION IRAQI FREEDOM; TRAUMA PATIENTS; BASE DEFICIT;
BLOOD-TRANSFUSION; SHOCK INDEX; UNITED-STATES; INJURY; COMPLICATIONS;
REQUIREMENTS; MULTICENTER
AB Background: US military Critical Care Air Transport Teams (CCATT) transport critically ill burn patients out of theater. Blood transfusion may incur adverse effects, and studies report lower hemoglobin (Hgb) value may be safe for critically ill patients. There are no studies evaluating the optimal Hgb value for critically ill burn patients prior to CCATT evacuation. Objective: The aim of the study was to determine if critically ill burn casualties with an Hgb of 10 g/dL or less, transported via CCATT, have similar clinical outcomes at 30 days as compared with patients with an Hgb of greater than 10 g/dL. Methods: We conducted an institutional review board-approved retrospective cohort study involving patients transported via CCATT. We separated our study population into two cohorts based on Hgb levels at the time of theater evacuation: Hgb <= 10 g/dL or Hgb >= 10 g/dL. We compared demographics, injury description, physiologic parameters, and clinical outcomes. Results: Of the 140 subjects enrolled, 29 were Hgb <= 10, and 111 were Hgb >= 10. Both groups were similar in age and percent total body surface area burned. Those Hgb e10 had a higher injury severity score (34 +/- 19.8 vs. 25 +/- 16.9, P = 0.02) and were more likely to have additional trauma (50% vs. 25%, P = 0.04). Modeling revealed no persistent differences in mortality, and other clinical outcomes measured. Conclusions: Critical Care Air Transport Teams transport of critically ill burn patients with an Hgb of 10 g/dL or less had no significant differences in complications or mortality as compared with patients with an Hgb of greater than 10 g/dL. In this study, lower hemoglobin levels did not confer greater risk for worse outcomes.
C1 [Hamilton, Joshua A.] San Antonio Uniformed Serv Hlth Educ Consortium, Dept Pulm & Crit Care Med, 3551 Rogers Brooke Dr, Ft Sam Houston, TX 78234 USA.
[Mora, Alejandra G.; Bebarta, Vikhyat S.] US Army Inst Surg Res, Air Force Enroute Care Res Ctr, San Antonio, TX USA.
[Chung, Kevin K.] Univ Hlth Sci, Uniformed Hlth Serv, US Army Inst Surg Res, San Antonio, TX USA.
RP Hamilton, JA (reprint author), San Antonio Uniformed Serv Hlth Educ Consortium, Dept Pulm & Crit Care Med, 3551 Rogers Brooke Dr, Ft Sam Houston, TX 78234 USA.
EM Joshua.A.Hamilton18.mil@mail.mil
RI bebarta, vikhyat/K-3476-2015
FU Department of Defense Joint Program Committee [JPC-6];
[W81XWH-13-2-0033]
FX Funded by the Department of Defense Joint Program Committee (JPC-6) and
awarded to the Geneva Foundation (W81XWH-13-2-0033).
NR 29
TC 1
Z9 1
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1073-2322
EI 1540-0514
J9 SHOCK
JI Shock
PD AUG
PY 2015
VL 44
SU 1
BP 50
EP 54
DI 10.1097/SHK.0000000000000336
PG 5
WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease
SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System
& Cardiology
GA DO3NA
UT WOS:000377687100009
PM 25643014
ER
PT J
AU Soller, B
Zou, FM
Prince, MD
Dubick, MA
Sondeen, JL
AF Soller, Babs
Zou, Fengmei
Prince, M. Dale
Dubick, Michael A.
Sondeen, Jill L.
TI COMPARISON OF NONINVASIVE PH AND BLOOD LACTATE AS PREDICTORS OF
MORTALITY IN A SWINE HEMORRHAGIC SHOCK WITH RESTRICTED VOLUME
RESUSCITATION MODEL
SO SHOCK
LA English
DT Article
DE Lactate; pH; hemorrhage; NIRS; mortality; prehospital; noninvasive
monitoring
ID NEAR-INFRARED SPECTROSCOPY; CRITICALLY-ILL PATIENTS; COMBAT CASUALTY
CARE; TRAUMA PATIENTS; OXYGEN-SATURATION; MUSCLE PH; LACTIC-ACIDOSIS;
SERUM LACTATE; SEVERE SEPSIS; SEPTIC SHOCK
AB Recent clinical studies have demonstrated that high blood lactate in the prehospital setting and poor lactate clearance in the emergency department are predictive of in-hospital mortality. This analysis of data collected from a swine model of hemorrhage and restricted volume resuscitation investigated the hypotheses that noninvasive muscle pH (pHm) and H+ clearance would predict mortality, and the responses would be similar between pHm and lactate. Data from a set of 57 swine were analyzed over the first 2 h after controlled hemorrhage and uncontrolled splenic bleeding. Surviving animals were ones that lived for the full 5-h experimental period. Venous lactate was determined at baseline, shock, and at 30, 60, and 120 min after injury. Spectra were collected continuously from the posterior thigh using a prototype CareGuide 1100 Oximeter and pHm calculated from the spectra; H+ concentration was determined from pHm. Lactate clearance rate was calculated from the difference in lactate concentration at 120 min and shock, and H+ clearance was calculated in a similar manner. Comparison of the area under the receiver operator characteristic curves was used to assess prediction of survival at 5 h after injury. At 120 min after injury, lactate, lactate clearance, noninvasive pHm, and noninvasive H+ clearance were equivalent predictors of mortality each with a receiver operator characteristic area under the curve of 0.87. Thresholds for single lactate (<3.8 mmol/L) or pHm (>7.30) determinations were found to be consistent with a resuscitation goal targeted to reverse acidosis. Continuous, noninvasive pHm monitoring may provide a substitute for lactate measurement in trauma patients, particularly in the prehospital and emergency department settings.
C1 [Soller, Babs; Zou, Fengmei] Reflectance Med Inc, 116 Flanders Rd,Suite 1000, Westborough, MA 01581 USA.
[Prince, M. Dale; Dubick, Michael A.; Sondeen, Jill L.] US Army Inst Surg Res, San Antonio, TX USA.
RP Soller, B (reprint author), Reflectance Med Inc, 116 Flanders Rd,Suite 1000, Westborough, MA 01581 USA.
EM babs.soller@reflectancemedical.com
FU US Army Medical Research and Materiel Command (USAMRMC)
[W81XWH-11-C-0001]; Defense Medical Research and Development Program
FX This work was supported by the US Army Medical Research and Materiel
Command (USAMRMC) under contract W81XWH-11-C-0001, USAMRMC Core Funds,
and the Defense Medical Research and Development Program.
NR 35
TC 3
Z9 4
U1 2
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1073-2322
EI 1540-0514
J9 SHOCK
JI Shock
PD AUG
PY 2015
VL 44
SU 1
BP 90
EP 95
DI 10.1097/SHK.0000000000000307
PG 6
WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease
SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System
& Cardiology
GA DO3NA
UT WOS:000377687100014
PM 25526374
ER
PT J
AU Darlington, DN
Gonzales, MD
Craig, T
Dubick, MA
Cap, AP
Schwacha, MG
AF Darlington, Daniel N.
Gonzales, Mary D.
Craig, Teresa
Dubick, Michael A.
Cap, Andrew P.
Schwacha, Martin G.
TI TRAUMA-INDUCED COAGULOPATHY IS ASSOCIATED WITH A COMPLEX INFLAMMATORY
RESPONSE IN THE RAT
SO SHOCK
LA English
DT Article
DE Hemorrhage; prothrombin time; cytokines; chemokines; growth factors
ID PLASMINOGEN-ACTIVATOR INHIBITOR; NECROSIS-FACTOR-ALPHA; TISSUE FACTOR;
IN-VIVO; COAGULATION; FIBRINOLYSIS; ENDOTHELIUM; PROTEIN; INJURY;
INTERLEUKIN-10
AB Severe trauma can lead to a coagulopathy in patients, which is associated with increased mortality. We developed a rat polytrauma model that demonstrates a similar progression of coagulopathy. Because coagulation is influenced by changes in inflammation, and this interrelationship is poorly understood, we have studied the progression of inflammation, and its correlation with coagulation, in this rat model of severe polytrauma. Sprague-Dawley rats were anesthetized with isoflurane. Polytrauma was induced by damaging 10 cm of small intestines, right and medial liver lobes, right leg skeletal muscle, femur fracture, and hemorrhaging 40% of blood volume. No resuscitation was given. Polytrauma and hemorrhage resulted in a significant decrease in the number of lymphocytes and an increase in monocytes and granulocytes. There was an increase in plasma proinflammatory cytokines: tumor necrosis factor alpha(40x), interleukin (IL)-6 (20x), IL-1 beta (16x), IL-17 (15x), interferon gamma (10x), IL-1 alpha (8x) and IL-12p70 (5x); anti-inflammatory cytokines: IL-10 (100x), IL-13 (16x), and IL-4 (5x); chemokines: growth-regulated protein/keratinocyte chemoattractant (30x), macrophage inflammatory protein 3 alpha (10x), regulated and normal T-cell expressed and secreted (3x); and growth factors: vascular endothelial growth factor (5x), granulocyte macrophage colony-stimulating factor (6x), macrophage colony-stimulating factor (3x), granulocyte colony-stimulating factor (2x), and IL-5 (3x). There was a strong and significant correlation between prothrombin time, activated partial thromboplastin time, fibrinogen, and fibrin monomer concentration, and many cytokines. Polytrauma with hemorrhage is associated with a coagulopathy and a complex inflammatory response consisting of a concurrent rise in both proinflammatory and anti-inflammatory cytokines. The rise in plasma concentrations of chemokines and growth factors likely contribute to the mobilization of monocytes and granulocytes. There is strong correlation between prothrombin time, activated partial thromboplastin time, and IL-10 and IL-1". This relationship could be exploited for the development of resuscitation strategies that attenuate these cytokines and allow for better outcomes in patients with trauma through concomitant modulation of inflammation and coagulopathy.
C1 [Darlington, Daniel N.; Gonzales, Mary D.; Dubick, Michael A.; Cap, Andrew P.; Schwacha, Martin G.] US Army Inst Surg Res, 3650 Chambers Pass, San Antonio, TX 78234 USA.
[Craig, Teresa; Dubick, Michael A.; Cap, Andrew P.; Schwacha, Martin G.] Univ Texas San Antonio, Hlth Sci Ctr, Dept Surg, San Antonio, TX USA.
RP Darlington, DN (reprint author), US Army Inst Surg Res, 3650 Chambers Pass, San Antonio, TX 78234 USA.
EM daniel.n.darlington.civ@mail.mil
FU US Army Medical Research Material Command
FX This work was supported by the US Army Medical Research Material
Command.
NR 42
TC 2
Z9 2
U1 2
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1073-2322
EI 1540-0514
J9 SHOCK
JI Shock
PD AUG
PY 2015
VL 44
SU 1
BP 129
EP 137
DI 10.1097/SHK.0000000000000354
PG 9
WC Critical Care Medicine; Hematology; Surgery; Peripheral Vascular Disease
SC General & Internal Medicine; Hematology; Surgery; Cardiovascular System
& Cardiology
GA DO3NA
UT WOS:000377687100019
PM 25664984
ER
PT J
AU Reshmi, SC
Harvey, RC
Smith, A
Chen, IM
Valentine, M
Liu, Y
Li, YJ
Zhang, JH
Roberts, KG
Shao, Y
Easton, J
Payne-Turner, D
Devidas, M
Heerema, N
Carroll, AJ
Raetz, EA
Borowitz, MJ
Wood, BL
Angiolillo, AL
Burke, MM
Salzer, WL
Zweidler-McKay, PA
Rabin, KR
Carroll, WL
Loh, ML
Hunger, SP
Mullighan, CG
Willman, CL
Gastier-Foster, JM
AF Reshmi, Shalini C.
Harvey, Richard C.
Smith, Amy
Chen, I-Ming
Valentine, Marc
Liu, Yu
Li, Yongjin
Zhang, Jinghui
Roberts, Kathryn G.
Shao, Ying
Easton, John
Payne-Turner, Debbie
Devidas, Meenakshi
Heerema, Nyla
Carroll, Andrew J.
Raetz, Elizabeth A.
Borowitz, Michael J.
Wood, Brent L.
Angiolillo, Anne L.
Burke, Michael M.
Salzer, Wanda L.
Zweidler-McKay, Patrick A.
Rabin, Karen R.
Carroll, William L.
Loh, Mignon L.
Hunger, Stephen P.
Mullighan, Charles G.
Willman, Cheryl L.
Gastier-Foster, Julie M.
TI Frequency of actionable gene fusions in patients with Philadelphia
chromosome-like (Ph-like) B-acute lymphoblastic leukemia (ALL): A
retrospective study from the Children's Oncology Group (COG)
SO CANCER RESEARCH
LA English
DT Meeting Abstract
CT 106th Annual Meeting of the American-Association-for-Cancer-Research
(AACR)
CY APR 18-22, 2015
CL Philadelphia, PA
SP Amer Assoc Canc Res
C1 [Reshmi, Shalini C.; Smith, Amy; Gastier-Foster, Julie M.] Nationwide Childrens Hosp, Columbus, OH USA.
[Harvey, Richard C.; Chen, I-Ming; Willman, Cheryl L.] Univ New Mexico, Albuquerque, NM 87131 USA.
[Valentine, Marc; Liu, Yu; Li, Yongjin; Zhang, Jinghui; Roberts, Kathryn G.; Shao, Ying; Easton, John; Payne-Turner, Debbie; Mullighan, Charles G.] St Jude Childrens Res Hosp, Memphis, TN 38105 USA.
[Devidas, Meenakshi] Univ Florida, Gainesville, FL USA.
[Heerema, Nyla] Ohio State Univ, Columbus, OH 43210 USA.
[Carroll, Andrew J.] Univ Alabama Birmingham, Birmingham, AL USA.
[Raetz, Elizabeth A.] Univ Utah, Salt Lake City, UT USA.
[Borowitz, Michael J.] Johns Hopkins Univ, Baltimore, MD USA.
[Wood, Brent L.] Seattle Childrens Hosp, Seattle, WA USA.
[Angiolillo, Anne L.] Childrens Natl Med Ctr, Washington, DC 20010 USA.
[Burke, Michael M.] Med Coll Wisconsin, Milwaukee, WI 53226 USA.
[Salzer, Wanda L.] US Army Med Res & Mat Command, Ft Detrick, MD USA.
[Zweidler-McKay, Patrick A.] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA.
[Rabin, Karen R.] Baylor Coll Med, Houston, TX 77030 USA.
[Carroll, William L.] NYU, Langone Med Ctr, New York, NY USA.
[Loh, Mignon L.] Univ Calif San Francisco, Benioff Childrens Hosp, San Francisco, CA 94143 USA.
[Hunger, Stephen P.] Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA.
NR 0
TC 0
Z9 0
U1 0
U2 0
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 0008-5472
EI 1538-7445
J9 CANCER RES
JI Cancer Res.
PD AUG 1
PY 2015
VL 75
SU 15
MA 4729
DI 10.1158/1538-7445.AM2015-4729
PG 2
WC Oncology
SC Oncology
GA DF8HA
UT WOS:000371597104357
ER
PT J
AU Ananworanich, J
Mellors, JW
AF Ananworanich, Jintanat
Mellors, John W.
TI How Much HIV is Alive? The Challenge of Measuring Replication Competent
HIV for HIV Cure Research
SO EBIOMEDICINE
LA English
DT Editorial Material
ID BIOMARKER
C1 [Ananworanich, Jintanat] US Mil HIV Res Program, Walter Reed Army Inst Res, Silver Spring, MD 20910 USA.
[Ananworanich, Jintanat] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA.
[Mellors, John W.] Univ Pittsburgh, Pittsburgh, PA USA.
RP Ananworanich, J (reprint author), US Mil HIV Res Program, Walter Reed Army Inst Res, Silver Spring, MD 20910 USA.
EM jananworanich@hivresearch.org
NR 9
TC 1
Z9 1
U1 0
U2 0
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 2352-3964
J9 EBIOMEDICINE
JI EBioMedicine
PD AUG
PY 2015
VL 2
IS 8
BP 788
EP 789
DI 10.1016/j.ebiom.2015.07.036
PG 2
WC Medicine, General & Internal
SC General & Internal Medicine
GA CX8LT
UT WOS:000365955900010
PM 26425677
ER
PT J
AU Nishimoto, P
Starr, U
AF Nishimoto, Patricia
Starr, Una
TI Supporting the Couple With Female Dyspareunia
SO CLINICAL JOURNAL OF ONCOLOGY NURSING
LA English
DT Article
DE sexuality; dyspareunia; vaginal dryness; libido
AB Patients receiving treatment for cancer often experience changes in sexual functioning but may be hesitant to ask questions. This article focuses on ways in which nurses can support patients and their partners and address their concerns through various evidence-based interventions.
At a Glance
center dot Sexuality, as well as how it is affected by cancer and its treatment, is an important aspect of holistic nursing care.
center dot Sexuality is not often brought up by nurses because of concern about a lack of evidence-based interventions.
center dot Many of the skills needed to inquire about sexual concerns are those that nurses use daily: active listening, sensitivity, and knowledge about how cancer and its treatment can physiologically affect sexual functioning.
C1 [Nishimoto, Patricia] Tripler Army Med Ctr, Honolulu, HI 96859 USA.
[Starr, Una] Argosy Univ, Hawaii Sch Profess Psychol, Honolulu, HI USA.
RP Nishimoto, P (reprint author), Tripler Army Med Ctr, Honolulu, HI 96859 USA.
EM patricia.w.nishimoto.civ@mail.mil
NR 3
TC 0
Z9 0
U1 1
U2 2
PU ONCOLOGY NURSING SOC
PI PITTSBURGH
PA 125 ENTERPRISE DR, PITTSBURGH, PA 15275 USA
SN 1092-1095
EI 1538-067X
J9 CLIN J ONCOL NURS
JI Clin. J. Oncol. Nurs.
PD AUG
PY 2015
VL 19
IS 4
BP 390
EP 392
DI 10.1188/15.CJON.390-392
PG 3
WC Oncology; Nursing
SC Oncology; Nursing
GA CX4PN
UT WOS:000365682900006
PM 26207701
ER
PT J
AU Tobler, KJ
Zhao, YL
Ross, R
Benner, AT
Xu, X
Du, LK
Broman, K
Thrift, K
Brezina, PR
Kearns, WG
AF Tobler, Kyle J.
Zhao, Yulian
Ross, Ric
Benner, Andy T.
Xu, Xin
Du, Luke
Broman, Kathleen
Thrift, Kim
Brezina, Paul R.
Kearns, William G.
TI Blastocoel fluid from differentiated blastocysts harbors embryonic
genomic material capable of a whole-genome deoxyribonucleic acid
amplification and comprehensive chromosome microarray analysis
SO FERTILITY AND STERILITY
LA English
DT Article
DE Blastocoel fluid; preimplantation genetic testing; microarray;
comparative genomic hybridization; preimplantation genetic screening
ID INNER CELL MASS; SELF-CORRECTION; STAGE; FISH; DNA; CGH; TROPHECTODERM;
VITRIFICATION; ANEUPLOIDY; MOSAICISM
AB Objective: To obtain embryonic molecular karyotypes from genomic DNA (deoxyribonucleic acid) isolated from blastocoel fluid (BF) and to compare these karyotypes with the karyotypes from the remaining inner cell mass (ICM) and trophectoderm (TE) of the blastocyst.
Design: Prospective cohort study.
Setting: Academic center and preimplantation genetics laboratory.
Patient(s): Ninety-six donated cryopreserved embryos.
Intervention(s): Embryo biopsy, BF aspiration, DNA analysis using a comparative genomic hybridization microarray (aCGH).
Main Outcome Measure(s): The aCGH of a single blastomere, BF-DNA, and ICM-TE.
Result(s): The BF-DNA samples resulted in a successful aCGH in 63% of cases. Discordance in karyotypes was found between the BF-DNA and the ICM-TE in 52% of cases. A total of 70% of aneusomic (mosaicism), cleavage-stage embryos differentiated into euploid blastocysts. Probabilities for diagnostic accuracy were calculated and demonstrated the following: sensitivity of 0.88 (95% confidence interval [CI]: 0.62-0.98); specificity of 0.55 (95% CI: 0.39-0.70); positive predictive value of 0.41 (95% CI: 0.25-0.60); negative predictive value of 0.92 (95% CI: 0.75-0.99).
Conclusion(s): Genomic DNA from the BF can be amplified and characterized by comprehensive chromosome microarrays. The results demonstrated that aneusomic cleavage-stage embryos differentiated into euploid blastocysts, possibly using a mechanism that marginalizes aneuploid nuclei into the blastocoel cavity. In addition, owing to the high discordance between the karyotypes obtained from the BF-DNA and the ICM-TE, using BF-DNA for preimplantation genetic testing is not yet advised. (C) 2015 byAmerican Society for Reproductive Medicine.
C1 [Tobler, Kyle J.; Zhao, Yulian; Broman, Kathleen; Thrift, Kim; Kearns, William G.] Johns Hopkins Univ, Sch Med, Dept Gynecol & Obstet, Div Reprod Endocrinol & Infertil, Baltimore, MD 21205 USA.
[Tobler, Kyle J.] US Army, Womack Med Ctr, Dept Obstet & Gynecol, Ft Bragg, NC 28307 USA.
[Ross, Ric] Ft Worth Fertil, Ft Worth, TX USA.
[Benner, Andy T.; Xu, Xin; Du, Luke; Kearns, William G.] AdvaGenix LLC, Rockville, MD USA.
[Brezina, Paul R.] Vanderbilt Univ, Sch Med, Dept Gynecol & Obstet, Div Reprod Endocrinol & Infertil, Memphis, TN USA.
[Brezina, Paul R.] St Jude Childrens Res Hosp, Dept Surg, Memphis, TN 38105 USA.
[Brezina, Paul R.] Fertil Associates Memphis, Memphis, TN USA.
RP Tobler, KJ (reprint author), US Army, Womack Med Ctr, Obstet & Gynecol, 2817 Reilly Rd, Ft Bragg, NC 28307 USA.
EM kyle.tobler@gmail.com
NR 26
TC 7
Z9 9
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0015-0282
EI 1556-5653
J9 FERTIL STERIL
JI Fertil. Steril.
PD AUG
PY 2015
VL 104
IS 2
BP 418
EP 425
DI 10.1016/j.fertnstert.2015.04.028
PG 8
WC Obstetrics & Gynecology; Reproductive Biology
SC Obstetrics & Gynecology; Reproductive Biology
GA CV0PX
UT WOS:000363954000025
PM 26006737
ER
PT J
AU Shannahan, L
Weerasooriya, T
Gunnarsson, A
Sanborn, B
Lamberson, L
AF Shannahan, Logan
Weerasooriya, Tusit
Gunnarsson, Allan
Sanborn, Brett
Lamberson, Leslie
TI Rate-dependent fracture modes in human femoral cortical bone
SO INTERNATIONAL JOURNAL OF FRACTURE
LA English
DT Article
DE Cortical bone; Mixed-mode fracture; Rate dependence; Critical stress
intensity factor
ID DIGITAL IMAGE CORRELATION; AGE-RELATED-CHANGES; DYNAMIC FRACTURE;
MECHANICAL-PROPERTIES; STRAIN RATES; BOVINE BONE; TOUGHNESS; DENSITY;
TENSILE; ORIENTATION
AB An accurate understanding of fracture in human bone under complex loading scenarios is critical to predicting fracture risk. Cortical bone, or dense compact bone, is subject to complex loading due to the inherent multi-axial loading conditions, which are also influenced by the anisotropy of the microstructure. When determining critical fracture parameters, bone is traditionally idealized as isotropic. This paper presents a method to examine rate-dependent mode mixity associated with cortical bone crack initiation. Four-point bend experiments have been conducted on cortical femoral bone samples from three human donors at quasi-static (slow), intermediate, and dynamic loading rates. Digital image correlation was used to obtain full-field displacement maps at the crack tip during the experiments. An over-deterministic least squares method is presented and used to evaluate Mode I (opening) and Mode II (shear) stress intensity factors (SIF) for fracture initiation at slow (10 MPa-ms), intermediate (15 MPa-ms), and high () stress intensity factor rates. Results show that under dynamic loading, the critical SIF in Mode I assuming material anisotropy is approximately 50 % lower than fracture toughness assuming isotropy. Additionally, critical Mode I and II SIFs had the lowest values at the highest rate of loading examined, decreasing to one third of the values under quasi-static loading. Crack growth in the low and intermediate SIF rates appears to be Mode II dominant, and shows a transition to completely mixed-mode at the high rate of loading. These results suggest that the conventional assumption of isotropy is a conservative estimate at low and intermediate rates, but overestimates fracture strength at dynamic rates.
C1 [Shannahan, Logan; Lamberson, Leslie] Drexel Univ, Dept Mech Engn & Mech, Philadelphia, PA 19104 USA.
[Weerasooriya, Tusit; Gunnarsson, Allan; Sanborn, Brett] US Army, Res Lab, Soldier Protect Sci Branch, Aberdeen Proving Ground, MD 21005 USA.
RP Lamberson, L (reprint author), Drexel Univ, Dept Mech Engn & Mech, Philadelphia, PA 19104 USA.
EM les@drexel.edu
FU Army Educational Outreach Program's College Qualified Leaders program
FX The authors would like to thank Prof. H. Tippur of Auburn University for
advice on understanding and implementing the over-deterministic least
squares analysis. This work was funded by the Army Educational Outreach
Program's College Qualified Leaders program.
NR 52
TC 1
Z9 1
U1 2
U2 10
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0376-9429
EI 1573-2673
J9 INT J FRACTURE
JI Int. J. Fract.
PD AUG
PY 2015
VL 194
IS 2
BP 81
EP 92
DI 10.1007/s10704-015-0035-0
PG 12
WC Materials Science, Multidisciplinary; Mechanics
SC Materials Science; Mechanics
GA CU5CZ
UT WOS:000363550700001
ER
PT J
AU Chaorattanakawee, S
Saunders, DL
Sea, D
Chanarat, N
Yingyuen, K
Sundrakes, S
Saingam, P
Buathong, N
Sriwichai, S
Charm, S
Se, Y
Yom, Y
Heng, TK
Kong, N
Kuntawunginn, W
Tangthongchaiwiriya, K
Jacob, C
Takala-Harrison, S
Plowe, C
Lin, JT
Chuor, CM
Prom, S
Tyner, SD
Gosi, P
Teja-Isavadharm, P
Lon, C
Lanteria, CA
AF Chaorattanakawee, Suwanna
Saunders, David L.
Sea, Darapiseth
Chanarat, Nitima
Yingyuen, Kritsanai
Sundrakes, Siratchana
Saingam, Piyaporn
Buathong, Nillawan
Sriwichai, Sabaithip
Charm, Soklyda
Se, Youry
Yom, You
Heng, Thay Kheng
Kong, Nareth
Kuntawunginn, Worachet
Tangthongchaiwiriya, Kuntida
Jacob, Christopher
Takala-Harrison, Shannon
Plowe, Christopher
Lin, Jessica T.
Chuor, Char Meng
Prom, Satharath
Tyner, Stuart D.
Gosi, Panita
Teja-Isavadharm, Paktiya
Lon, Chanthap
Lanteria, Charlotte A.
TI Ex Vivo Drug Susceptibility Testing and Molecular Profiling of Clinical
Plasmodium falciparum Isolates from Cambodia from 2008 to 2013 Suggest
Emerging Piperaquine Resistance
SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
LA English
DT Article
ID IN-VITRO RESPONSES; DIHYDROARTEMISININ-PIPERAQUINE; ARTEMISININ
RESISTANCE; COPY NUMBER; PYRONARIDINE-ARTESUNATE; MEFLOQUINE
COMBINATION; ANTIMALARIAL-DRUGS; SOUTHEAST-ASIA; CYTOCHROME-B; MALARIA
AB Cambodia's first-line artemisinin combination therapy, dihydroartemisinin-piperaquine (DHA-PPQ), is no longer sufficiently curative against multidrug-resistant Plasmodium falciparum malaria at some Thai-Cambodian border regions. We report recent (2008 to 2013) drug resistance trends in 753 isolates from northern, western, and southern Cambodia by surveying for ex vivo drug susceptibility and molecular drug resistance markers to guide the selection of an effective alternative to DHA-PPQ. Over the last 3 study years, PPQ susceptibility declined dramatically (geomean 50% inhibitory concentration [IC50] increased from 12.8 to 29.6 nM), while mefloquine (MQ) sensitivity doubled (67.1 to 26 nM) in northern Cambodia. These changes in drug susceptibility were significantly associated with a decreased prevalence of P. fakiparum multidrug resistance 1 gene (Pfmdr1) multiple copy isolates and coincided with the timing of replacing artesunate-mefloquine (AS-MQ) with DHA-PPQ as the first-line therapy. Widespread chloroquine resistance was suggested by all isolates being of the P. falciparum chloroquine resistance transporter gene CVIET haplotype. Nearly all isolates collected from the most recent years had P. fakiparum kelchI3 mutations, indicative of artemisinin resistance. Ex vivo bioassay measurements of antimalarial activity in plasma indicated 20% of patients recently took antimalarials, and their plasma had activity (median of 49.8 nM DHA equivalents) suggestive of substantial in vivo drug pressure. Overall, our findings suggest DHA-PPQ failures are associated with emerging PPQ resistance in a background of artemisinin resistance. The observed connection between drug policy changes and significant reduction in PPQ susceptibility with mitigation of MQ resistance supports reintroduction of AS-MQ, in conjunction with monitoring of the P. falciparum indr1 copy number, as a stop-gap measure in areas of DHA-PPQ failure.
C1 [Chaorattanakawee, Suwanna; Saunders, David L.; Sea, Darapiseth; Chanarat, Nitima; Yingyuen, Kritsanai; Sundrakes, Siratchana; Saingam, Piyaporn; Buathong, Nillawan; Sriwichai, Sabaithip; Charm, Soklyda; Se, Youry; Kuntawunginn, Worachet; Tangthongchaiwiriya, Kuntida; Tyner, Stuart D.; Gosi, Panita; Teja-Isavadharm, Paktiya; Lon, Chanthap; Lanteria, Charlotte A.] Armed Forces Res Inst Med Sci, Dept Immunol & Med, Bangkok 10400, Thailand.
[Yom, You; Heng, Thay Kheng; Kong, Nareth; Chuor, Char Meng] Natl Ctr Parasitol Entomol & Malaria Control, Phnom Penh, Cambodia.
[Jacob, Christopher; Takala-Harrison, Shannon; Plowe, Christopher] Univ Maryland, Sch Med, Howard Hughes Med Inst, Ctr Vaccine Dev, Baltimore, MD 21201 USA.
[Lin, Jessica T.] Univ N Carolina, Div Infect Dis, Sch Med, Chapel Hill, NC USA.
[Prom, Satharath] Royal Cambodian Armed Forces, Phnom Penh, Cambodia.
RP Lanteria, CA (reprint author), Armed Forces Res Inst Med Sci, Dept Immunol & Med, Bangkok 10400, Thailand.
EM charlotte.a.lanteria@mail.th
FU Global Emerging Infections Surveillance (GEIS) Program, Armed Forces
Health Surveillance Center (AFHSC), U.S. Department of Defense
FX This work was funded by the Global Emerging Infections Surveillance
(GEIS) Program, Armed Forces Health Surveillance Center (AFHSC), U.S.
Department of Defense.
NR 61
TC 20
Z9 20
U1 0
U2 2
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0066-4804
EI 1098-6596
J9 ANTIMICROB AGENTS CH
JI Antimicrob. Agents Chemother.
PD AUG
PY 2015
VL 59
IS 8
BP 4631
EP 4643
DI 10.1128/AAC.00366-15
PG 13
WC Microbiology; Pharmacology & Pharmacy
SC Microbiology; Pharmacology & Pharmacy
GA CT6VY
UT WOS:000362952000038
PM 26014942
ER
PT J
AU Brown, DRN
Jorgenson, MT
Douglas, TA
Romanovsky, VE
Kielland, K
Hiemstra, C
Euskirchen, ES
Ruess, RW
AF Brown, Dana R. N.
Jorgenson, M. Torre
Douglas, Thomas A.
Romanovsky, Vladimir E.
Kielland, Knut
Hiemstra, Christopher
Euskirchen, Eugenie S.
Ruess, Roger W.
TI Interactive effects of wildfire and climate on permafrost degradation in
Alaskan lowland forests
SO JOURNAL OF GEOPHYSICAL RESEARCH-BIOGEOSCIENCES
LA English
DT Article
ID INTERIOR ALASKA; DISCONTINUOUS PERMAFROST; BOREAL PEATLANDS; CARBON
DYNAMICS; ACTIVE LAYER; FIRE; CANADA; THAW; VULNERABILITY; RESILIENCE
AB We examined the effects of fire disturbance on permafrost degradation and thaw settlement across a series of wildfires (from similar to 1930 to 2010) in the forested areas of collapse-scar bog complexes in the Tanana Flats lowland of interior Alaska. Field measurements were combined with numerical modeling of soil thermal dynamics to assess the roles of fire severity and climate history in postfire permafrost dynamics. Field-based calculations of potential thaw settlement following the loss of remaining ice-rich permafrost averaged 0.6 m. This subsidence would cause the surface elevations of forests to drop on average 0.1 m below the surface water level of adjacent collapse-scar features. Up to 0.5 m of thaw settlement was documented after recent fires, causing water impoundment and further thawing along forest margins. Substantial heterogeneity in soil properties (organic layer thickness, texture, moisture, and ice content) was attributed to differing site histories, which resulted in distinct soil thermal regimes by soil type. Model simulations showed increasing vulnerability of permafrost to deep thawing and thaw settlement with increased fire severity (i.e., reduced organic layer thickness). However, the thresholds of fire severity that triggered permafrost destabilization varied temporally in response to climate. Simulated permafrost dynamics underscore the importance of multiyear to multidecadal fluctuations in air temperature and snow depth in mediating the effects of fire on permafrost. Our results suggest that permafrost is becoming increasingly vulnerable to substantial thaw and collapse after moderate to high-severity fire, and the ability of permafrost to recover is diminishing as the climate continues to warm.
C1 [Brown, Dana R. N.; Kielland, Knut; Ruess, Roger W.] Univ Alaska, Dept Biol & Wildlife, Fairbanks, AK 99701 USA.
[Brown, Dana R. N.; Kielland, Knut; Euskirchen, Eugenie S.; Ruess, Roger W.] Univ Alaska Fairbanks, Inst Arctic Biol, Fairbanks, AK USA.
[Jorgenson, M. Torre] Alaska Ecosci, Fairbanks, AK USA.
[Douglas, Thomas A.; Hiemstra, Christopher] US Army Cold Reg Res & Engn Lab, Ft Wainwright, AK USA.
[Romanovsky, Vladimir E.] Univ Alaska Fairbanks, Inst Geophys, Fairbanks, AK 99775 USA.
[Romanovsky, Vladimir E.] Tyumen State Oil & Gas Univ, Tyumen, Russia.
RP Brown, DRN (reprint author), Univ Alaska, Dept Biol & Wildlife, Fairbanks, AK 99701 USA.
EM drnossov@alaska.edu
FU Department of Defense's Strategic Environmental Research and Development
Program [RC-2110]; Changing Arctic Ecosystems Initiative of the U.S.
Geological Survey's Ecosystem Mission Area; Bonanza Creek Long Term
Ecological Research Program - National Science Foundation [DEB-0423442];
Bonanza Creek Long Term Ecological Research Program - USDA Forest
Service, Pacific Northwest Research Station [PNW-01-JV-11261952-231];
Alaska Cooperative Fish and Wildlife Research Unit; Institute of Arctic
Biology at the University of Alaska Fairbanks
FX Data used in this article are available upon request to the
corresponding author. This research was funded by the Department of
Defense's Strategic Environmental Research and Development Program
(project RC-2110), the Changing Arctic Ecosystems Initiative of the U.S.
Geological Survey's Ecosystem Mission Area, and the Bonanza Creek Long
Term Ecological Research Program, funded jointly by the National Science
Foundation (DEB-0423442) and the USDA Forest Service, Pacific Northwest
Research Station (PNW-01-JV-11261952-231). The Alaska Cooperative Fish
and Wildlife Research Unit and the Institute of Arctic Biology at the
University of Alaska Fairbanks provided support. We thank Amanda Barker,
Maria Berkeland, Kevin Bjella, Seth Campbell, Tiffany Gatesman, Art
Gelvin, Helene Genet, Sarah Hayes, Karen Jorgenson, Mark Lara, Anna
Liljedahl, Heikki Lotvonen, Katie Nicolato, Stephanie Saari, and Anna
Wagner for all of their help with this project.
NR 65
TC 9
Z9 9
U1 8
U2 35
PU AMER GEOPHYSICAL UNION
PI WASHINGTON
PA 2000 FLORIDA AVE NW, WASHINGTON, DC 20009 USA
SN 2169-8953
EI 2169-8961
J9 J GEOPHYS RES-BIOGEO
JI J. Geophys. Res.-Biogeosci.
PD AUG
PY 2015
VL 120
IS 8
BP 1619
EP 1637
DI 10.1002/2015JG003033
PG 19
WC Environmental Sciences; Geosciences, Multidisciplinary
SC Environmental Sciences & Ecology; Geology
GA CU2DG
UT WOS:000363332300012
ER
PT J
AU Chi, GQ
Brown, W
Zhang, X
Zheng, YB
AF Chi, Guangqing
Brown, Willie
Zhang, Xiang
Zheng, Yanbing
TI Safer Roads Owing to Higher Gasoline Prices: How Long It Takes
SO AMERICAN JOURNAL OF PUBLIC HEALTH
LA English
DT Article
ID TRAFFIC FATALITIES; CRASHES; TAXES; US; INFRASTRUCTURE; ENFORCEMENT;
REDUCTIONS; ACCIDENTS; TRENDS; URBAN
AB Objectives. We investigated how much time passes before gasoline price changes affect traffic crashes.
Methods. We systematically examined 2004 to 2012 Mississippi traffic crash data by age, gender, and race. Control variables were unemployment rate, seat belt use, alcohol consumption, climate, and temporal and seasonal variations.
Results. We found a positive association between higher gasoline prices and safer roads. Overall, gasoline prices affected crashes 9 to 10 months after a price change. This finding was generally consistent across age, gender, and race, with some exceptions. For those aged 16 to 19 years, gasoline price increases had an immediate (although statistically weak) effect and a lagged effect, but crashes involving those aged 25 to 34 years was seemingly unaffected by price changes. For older individuals (>= 75 years), the lagged effect was stronger and lasted longer than did that of other age groups.
Conclusions. The results have important health policy implications for using gasoline prices and taxes to improve traffic safety.
C1 [Chi, Guangqing] Penn State Univ, Dept Agr Econ Sociol & Educ, Populat Res Inst, University Pk, PA 16802 USA.
[Chi, Guangqing] Penn State Univ, Social Sci Res Inst, University Pk, PA 16802 USA.
[Brown, Willie] US Army Engineer Res & Dev Ctr, Informat Technol Lab, Vicksburg, MS USA.
[Zhang, Xiang; Zheng, Yanbing] Univ Kentucky, Dept Stat, Lexington, KY 40506 USA.
RP Chi, GQ (reprint author), Penn State Univ, Dept Agr Econ Sociol & Educ, 103 Armsby Bldg, University Pk, PA 16802 USA.
EM gchi@psu.edu
FU Public Safety Data Laboratory, Mississippi Office of Highway Safety
[017090-001]
FX This research was partly supported by the Public Safety Data Laboratory,
Mississippi Office of Highway Safety (grant 017090-001).
NR 45
TC 0
Z9 0
U1 2
U2 5
PU AMER PUBLIC HEALTH ASSOC INC
PI WASHINGTON
PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA
SN 0090-0036
EI 1541-0048
J9 AM J PUBLIC HEALTH
JI Am. J. Public Health
PD AUG
PY 2015
VL 105
IS 8
BP E119
EP E125
DI 10.2105/AJPH.2015.302579
PG 7
WC Public, Environmental & Occupational Health
SC Public, Environmental & Occupational Health
GA CT6VL
UT WOS:000362950400023
PM 26066946
ER
PT J
AU Krueger, CA
Rivera, JC
Tennent, DJ
Sheean, AJ
Stinner, DJ
Wenke, JC
AF Krueger, Chad A.
Rivera, Jessica C.
Tennent, David J.
Sheean, Andrew J.
Stinner, Daniel J.
Wenke, Joseph C.
TI Late amputation may not reduce complications or improve mental health in
combat-related, lower extremity limb salvage patients
SO INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
LA English
DT Article
DE Late amputation; Limb salvage; Limb reconstruction; Combat injury; PTSD
ID OPERATION IRAQI FREEDOM; OPEN TIBIA FRACTURE; INFECTIOUS COMPLICATIONS;
ORTHOPEDIC TRAUMA; INJURY-SEVERITY; OUTCOMES; REHABILITATION; MILITARY;
RETURN; DUTY
AB Introduction: Following severe lower extremity trauma, patients who undergo limb reconstruction and amputations both endure frequent complications and mental health sequelae. The purpose of this study is to assess the extent to which late amputation following a period of limb salvage impacts the evolution of the clinical variables that can affect the patient's perception of his or her limb: ongoing limb associated complications and mental health conditions.
Patients and methods: A case series of US service members who sustained a late major extremity amputation from September 2001 through July 2011 were analysed. Pre-and post-amputation complications, mental health conditions, and reason(s) for desiring amputation were recorded.
Results: Forty-four amputees with detailed demographic, injury and treatment data were identified. The most common reasons for desiring a late amputation were pain and being dissatisfied with the function of the salvage limb. An average of 3.2 (range 1-10) complications were reported per amputee prior to undergoing late amputation and an average of 1.8 (range 0-5) complications reported afterwards. The most common complication prior to and after late amputation was soft tissue infection (24 (17%) and 9 (22%), respectively). Twenty-nine (64%) late amputees were diagnosed with a mental health condition prior to undergoing their amputation and 27 (61%) late amputees were diagnosed with mental conditions after late amputation. Only three of the 15 patients who did not have a mental health condition documented prior to their late amputation remained free of a documented mental health condition after the amputation.
Discussion: Ongoing complications and mental health conditions can affect how a patient perceives and copes with his or her limb following severe trauma. Patient dissatisfaction following limb reconstruction can influence the decision to undergo a late amputation. Patients with a severe, combat related lower extremity injury that are undergoing limb salvage may not have a reduction in their overall complication rate, a resolution of specific complications or an improvement of their mental health after undergoing late amputation.
Conclusion: Surgeons caring for limb salvage patients should counsel appropriately when managing expectations for a patient who desires a late amputation. Published by Elsevier Ltd.
C1 [Krueger, Chad A.; Tennent, David J.; Sheean, Andrew J.] San Antonio Mil Med Ctr, Ft Sam Houston, TX 78234 USA.
[Rivera, Jessica C.; Stinner, Daniel J.; Wenke, Joseph C.] US Army Inst Surg Res, Ft Sam Houston, TX USA.
RP Krueger, CA (reprint author), San Antonio Mil Med Ctr, Orthopaed Surg, 3551 Roger Brooke Dr, Ft Sam Houston, TX 78234 USA.
EM cak0705@gmail.com
NR 44
TC 4
Z9 4
U1 1
U2 3
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0020-1383
EI 1879-0267
J9 INJURY
JI Injury-Int. J. Care Inj.
PD AUG
PY 2015
VL 46
IS 8
BP 1527
EP 1532
DI 10.1016/j.injury.2015.05.015
PG 6
WC Critical Care Medicine; Emergency Medicine; Orthopedics; Surgery
SC General & Internal Medicine; Emergency Medicine; Orthopedics; Surgery
GA CS2IR
UT WOS:000361894200017
PM 26003681
ER
PT J
AU Palacios, G
Wiley, MR
da Rosa, APAT
Guzman, H
Quiroz, E
Savji, N
Carrera, JP
Bussetti, AV
Ladner, JT
Lipkin, WI
Tesh, RB
AF Palacios, Gustavo
Wiley, Michael R.
da Rosa, Amelia P. A. Travassos
Guzman, Hilda
Quiroz, Evelia
Savji, Nazir
Carrera, Jean-Paul
Bussetti, Ana Valeria
Ladner, Jason T.
Lipkin, W. Ian
Tesh, Robert B.
TI Characterization of the Punta Toro species Communication complex (genus
Phlebovirus, family Bunyaviridae)
SO JOURNAL OF GENERAL VIROLOGY
LA English
DT Article
ID HEMORRHAGIC-FEVER VIRUS; GENETIC-CHARACTERIZATION; MOLECULAR
EPIDEMIOLOGY; M-SEGMENT; REASSORTMENT; SEQUENCES; ORTHOBUNYAVIRUSES;
RECOMBINATION; MOSQUITOS; TIME
AB Punta Toro virus (PTV), a member of the PTV complex, is a relatively common causative agent of febrile illness in Panama that is often misdiagnosed as 'dengue' or 'influenza'. Currently, only two named members make up this species complex, PTV and Buenaventura virus (BUEV). Genomic and antigenic characterization of 17 members of the PTV complex, nine of which were isolated from human acute febrile illness cases, reveals that this species complex is composed of six distant viruses. We propose to add four additional new viruses, designated Leticia virus, Code virus, Campana virus and Capira virus.
C1 [Palacios, Gustavo; Wiley, Michael R.; Ladner, Jason T.] US Army Med Res Inst Infect Dis, Ctr Genome Sci, Frederick, MD 21702 USA.
[da Rosa, Amelia P. A. Travassos; Guzman, Hilda; Tesh, Robert B.] Univ Texas Med Branch, Dept Pathol, Ctr Biodefense & Emerging Infect Dis, Galveston, TX 77555 USA.
[Quiroz, Evelia; Carrera, Jean-Paul] Gorgas Mem Inst Hlth Studies, Dept Virol & Biotechnol Res, Panama City, Panama.
[Quiroz, Evelia] Univ Panama, Dept Microbiol, Panama City, Panama.
[Savji, Nazir] NYU, Sch Med, New York, NY USA.
[Carrera, Jean-Paul] Columbus Univ, Sch Med, Panama City, Panama.
[Bussetti, Ana Valeria; Lipkin, W. Ian] Columbia Univ, Ctr Infect & Immun, New York, NY USA.
RP Palacios, G (reprint author), US Army Med Res Inst Infect Dis, Ctr Genome Sci, Frederick, MD 21702 USA.
EM Gustavo.f.palacios.ctr@us.army.mil
RI Palacios, Gustavo/I-7773-2015
OI Palacios, Gustavo/0000-0001-5062-1938
FU Defense Threat Reduction Agency [1881290]; United States Department of
Defense; Google.org; National Institutes of Health [AI57158]; USAID
PREDICT [07-301-7119-52258]; NIH [HHSN272201000040I/HHSN27200004/D04];
Secretaria Nacional de Ciencia y Tecnologia e Inovacion, Panama
[60-4-FID09-103]
FX Opinions, interpretations, conclusions and recommendations are those of
the author and are not necessarily endorsed by the U.S. Army. This work
was supported by the Defense Threat Reduction Agency no. 1881290, and
the United States Department of Defense, Google.org, National Institutes
of Health award AI57158 (North-east Biodefence Center - Lipkin), and
USAID PREDICT funding source code 07-301-7119-52258 (Center for
Infection and Immunity). R. T., A. T. R. and H. G. were supported by NIH
contract HHSN272201000040I/HHSN27200004/D04. J. P. C. was supported by
Secretaria Nacional de Ciencia y Tecnologia e Inovacion, Panama code:
60-4-FID09-103.
NR 41
TC 5
Z9 5
U1 0
U2 1
PU SOC GENERAL MICROBIOLOGY
PI READING
PA MARLBOROUGH HOUSE, BASINGSTOKE RD, SPENCERS WOODS, READING RG7 1AG,
BERKS, ENGLAND
SN 0022-1317
EI 1465-2099
J9 J GEN VIROL
JI J. Gen. Virol.
PD AUG
PY 2015
VL 96
BP 2079
EP 2085
DI 10.1099/vir.0.000170
PN 8
PG 7
WC Biotechnology & Applied Microbiology; Virology
SC Biotechnology & Applied Microbiology; Virology
GA CS7CZ
UT WOS:000362243000010
PM 25934793
ER
PT J
AU Ryu, S
Capell, C
Van Brunt, E
Jonas, C
O'Loughlin, M
Clayton, J
Lam, K
Pala, V
Hull, B
Lemma, Y
Lichtenwalner, D
Zhang, QJ
Richmond, J
Butler, P
Grider, D
Casady, J
Allen, S
Palmour, J
Hinojosa, M
Tipton, CW
Scozzie, C
AF Ryu, S.
Capell, C.
Van Brunt, E.
Jonas, C.
O'Loughlin, M.
Clayton, J.
Lam, K.
Pala, V.
Hull, B.
Lemma, Y.
Lichtenwalner, D.
Zhang, Q. J.
Richmond, J.
Butler, P.
Grider, D.
Casady, J.
Allen, S.
Palmour, J.
Hinojosa, M.
Tipton, C. W.
Scozzie, C.
TI Ultra high voltage MOS controlled 4H-SiC power switching devices
SO SEMICONDUCTOR SCIENCE AND TECHNOLOGY
LA English
DT Article
DE silicon carbide; MOSFET; IGBT; ultra high voltage
ID IGBTS
AB Ultra high voltage (UHV, >15 kV) 4H-silicon carbide (SiC) power devices have the potential to significantly improve the system performance, reliability, and cost of energy conversion systems by providing reduced part count, simplified circuit topology, and reduced switching losses. In this paper, we compare the two MOS based UHV 4H-SiC power switching devices; 15 kV 4H-SiC MOSFETs and 15 kV 4H-SiC n-IGBTs. The 15 kV 4H-SiC MOSFET shows a specific on-resistance of 204 m Omega cm(2) at 25 degrees C, which increased to 570 m Omega cm(2) at 150 degrees C. The 15 kV 4H-SiC MOSFET provides low, temperature-independent, switching losses which makes the device more attractive for applications that require higher switching frequencies. The 15 kV 4H-SiC n-IGBT shows a significantly lower forward voltage drop (V-F), along with reasonable switching performance, which make it a very attractive device for high voltage applications with lower switching frequency requirements. An electrothermal analysis showed that the 15 kV 4H-SiC n-IGBT outperforms the 15 kV 4H-SiC MOSFET for applications with switching frequencies of less than 5 kHz. It was also shown that the use of a carrier storage layer (CSL) can significantly improve the conduction performance of the 15 kV 4H-SiC n-IGBTs.
C1 [Ryu, S.; Capell, C.; Van Brunt, E.; Jonas, C.; O'Loughlin, M.; Clayton, J.; Lam, K.; Pala, V.; Hull, B.; Lemma, Y.; Lichtenwalner, D.; Zhang, Q. J.; Richmond, J.; Butler, P.; Grider, D.; Casady, J.; Allen, S.; Palmour, J.] Cree Inc, Durham, NC 27703 USA.
[Hinojosa, M.; Tipton, C. W.; Scozzie, C.] US Army Res Lab, Adelphi, MD USA.
RP Ryu, S (reprint author), Cree Inc, 4600 Silicon Dr, Durham, NC 27703 USA.
EM sei-hyung_ryu@cree.com
FU ARL [W911NF-10-2-0038]
FX This work is supported by ARL Cooperative Agreement #W911NF-10-2-0038,
monitored by Dr C Scozzie.
NR 14
TC 10
Z9 10
U1 5
U2 28
PU IOP PUBLISHING LTD
PI BRISTOL
PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
SN 0268-1242
EI 1361-6641
J9 SEMICOND SCI TECH
JI Semicond. Sci. Technol.
PD AUG
PY 2015
VL 30
IS 8
AR 084001
DI 10.1088/0268-1242/30/8/084001
PG 7
WC Engineering, Electrical & Electronic; Materials Science,
Multidisciplinary; Physics, Condensed Matter
SC Engineering; Materials Science; Physics
GA CS7OI
UT WOS:000362272600002
ER
PT J
AU Dobson, GP
Letson, HL
Sharma, R
Sheppard, FR
Cap, AP
AF Dobson, Geoffrey P.
Letson, Hayley L.
Sharma, Rajiv
Sheppard, Forest R.
Cap, Andrew P.
TI Mechanisms of early trauma-induced coagulopathy: The clot thickens or
not?
SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
LA English
DT Review
ID DISSEMINATED INTRAVASCULAR COAGULATION; THROMBIN GENERATION; FIBRINOGEN
CONCENTRATE; ANTIFIBRINOLYTIC THERAPY; MAJOR TRAUMA; PROTEIN-C; SHOCK;
INJURY; THROMBOELASTOMETRY; HYPERFIBRINOLYSIS
AB Traumatic-induced coagulopathy (TIC) is a hemostatic disorder that is associated with significant bleeding, transfusion requirements, morbidity and mortality. A disorder similar or analogous to TIC was reported around 70 years ago in patients with shock, hemorrhage, burns, cardiac arrest or undergoing major surgery, and the condition was referred to as a severe bleeding tendency, defibrination syndrome, consumptive disorder, and later by surgeons treating US Vietnam combat casualties as a diffuse oozing coagulopathy. In 1982, Moore's group termed it the bloody vicious cycle, others the lethal triad, and in 2003 Brohi and colleagues introduced acute traumatic coagulopathy (ATC). Since that time, early TIC has been cloaked in many names and acronyms, including a fibrinolytic form of disseminated intravascular coagulopathy (DIC). A global consensus on naming is urgently required to avoid confusion. In our view, TIC is a dynamic entity that evolves over time and no single hypothesis adequately explains the different manifestations of the coagulopathy. However, early TIC is not DIC because an increased thrombin-generating potential in vitro does not imply a clinically relevant thrombotic state in vivo as early TIC is characterized by excessive bleeding, not thrombosis. DIC with its diffuse anatomopathologic fibrin deposition appears to be a latter phase progression of TIC associated with unchecked inflammation and multiple organ dysfunction.
C1 [Dobson, Geoffrey P.; Letson, Hayley L.; Sharma, Rajiv] James Cook Univ, Coll Med & Dent, Australian Inst Trop Hlth & Med, Heart Trauma & Sepsis Res Lab, Townsville, Qld 4811, Australia.
[Sheppard, Forest R.] Naval Med Res Unit San Antonio, San Antonio, TX USA.
[Cap, Andrew P.] Uniformed Serv Univ Hlth Sci, US Army, Inst Surg Res, JBSA Fort Sam Houston, San Antonio, TX USA.
RP Dobson, GP (reprint author), James Cook Univ, Townsville, Qld 4811, Australia.
EM geoffrey.dobson@jcu.edu.au
FU James Cook University; US SOCOM, Department of Defense
[W81XWH-15-1-0002]
FX G.P.D. is the sole inventor of the ALM concept for cardioplegia,
surgery, infection, and trauma. H.L.L. and R.S. have no conflicts to
declare. This study was supported by internal research assistance (IRA)
from James Cook University and US SOCOM, Department of Defense Award No.
W81XWH-15-1-0002 (to G.P.D. and H.L.L.).
NR 77
TC 17
Z9 17
U1 3
U2 11
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 2163-0755
EI 2163-0763
J9 J TRAUMA ACUTE CARE
JI J. Trauma Acute Care Surg.
PD AUG
PY 2015
VL 79
IS 2
BP 301
EP 309
DI 10.1097/TA.0000000000000729
PG 9
WC Critical Care Medicine; Surgery
SC General & Internal Medicine; Surgery
GA CS2II
UT WOS:000361892800021
PM 26218701
ER
PT J
AU Studer, NM
Horn, GT
AF Studer, Nicholas M.
Horn, Gregory T.
TI Re: Optimal training for emergency needle thoracostomy
SO JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
LA English
DT Letter
C1 [Studer, Nicholas M.] Brooke Army Med Ctr, San Antonio, TX 78234 USA.
[Horn, Gregory T.] Walter Reed Natl Mil Med Ctr, Bethesda, MD USA.
RP Studer, NM (reprint author), Brooke Army Med Ctr, San Antonio, TX 78234 USA.
NR 3
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 2163-0755
EI 2163-0763
J9 J TRAUMA ACUTE CARE
JI J. Trauma Acute Care Surg.
PD AUG
PY 2015
VL 79
IS 2
BP 331
EP 331
DI 10.1097/TA.0000000000000710
PG 1
WC Critical Care Medicine; Surgery
SC General & Internal Medicine; Surgery
GA CS2IJ
UT WOS:000361893000002
PM 26218706
ER
PT J
AU Groom, RM
Carr, RB
Leong, SL
Hornbaker-Park, MB
AF Groom, Rhianon M.
Carr, Russell B.
Leong, Stephanie L.
Hornbaker-Park, Michelle B.
TI Impact of an Enduring War on Two Military Psychiatry Residency Programs
SO ACADEMIC PSYCHIATRY
LA English
DT Article
DE Residents; Curriculum development; Professional development
AB Four active duty military psychiatrists at different points in their careers were asked to reflect on the impact that the wars in Iraq and Afghanistan had on their respective training in military psychiatry residency programs. The result is an inside look from four unique perspectives on how military psychiatry residency training adapted over time to prepare their graduates to practice psychiatry in a wartime setting as many graduates went to the front lines of war shortly after graduation. This article will provide an understanding of the challenges faced by these residency programs striving to meet the behavioral health needs created by war while balancing this with ongoing ACGME requirements, how those challenges were met, and the impact it had on residents.
C1 [Groom, Rhianon M.] Blanchfield Army Community Hosp, Ft Campbell, KY 42223 USA.
[Carr, Russell B.] Walter Reed Natl Mil Med Ctr, Bethesda, MD USA.
[Leong, Stephanie L.] Tripler Army Med Ctr, Honolulu, HI 96859 USA.
[Hornbaker-Park, Michelle B.] 101st Airborne Div, Ft Campbell, KY USA.
RP Groom, RM (reprint author), Blanchfield Army Community Hosp, Ft Campbell, KY 42223 USA.
EM rhianon.groom@gmail.com
NR 19
TC 2
Z9 2
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1042-9670
EI 1545-7230
J9 ACAD PSYCHIATR
JI Acad. Psych.
PD AUG
PY 2015
VL 39
IS 4
BP 354
EP 359
DI 10.1007/s40596-015-0284-2
PG 6
WC Education & Educational Research; Psychiatry
SC Education & Educational Research; Psychiatry
GA CR1OA
UT WOS:000361093500003
PM 25739934
ER
PT J
AU Lee, PC
Leong, SL
Egan, KJ
Ellis, NS
Ahmed, I
AF Lee, Paul C.
Leong, Stephanie L.
Egan, Kathryn J.
Ellis, Nathan S.
Ahmed, Iqbal
TI Improving Training and Systems of Care in Child and Adolescent
Consultation-Liaison Psychiatry Through Patient-Centered Graduate
Medical Education: One Institution's Approach
SO ACADEMIC PSYCHIATRY
LA English
DT Article
ID HEALTH-CARE
C1 [Lee, Paul C.; Leong, Stephanie L.; Egan, Kathryn J.; Ellis, Nathan S.; Ahmed, Iqbal] Tripler Army Med Ctr, Honolulu, HI 96859 USA.
RP Lee, PC (reprint author), Tripler Army Med Ctr, Honolulu, HI 96859 USA.
EM paul.c.lee23.civ@mail.mil
NR 10
TC 1
Z9 1
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1042-9670
EI 1545-7230
J9 ACAD PSYCHIATR
JI Acad. Psych.
PD AUG
PY 2015
VL 39
IS 4
BP 389
EP 392
DI 10.1007/s40596-015-0299-8
PG 4
WC Education & Educational Research; Psychiatry
SC Education & Educational Research; Psychiatry
GA CR1OA
UT WOS:000361093500009
PM 25788337
ER
PT J
AU Diebold, CJ
Leong, SL
Zuchowski, S
Gibson, RT
AF Diebold, Carroll J.
Leong, Stephanie L.
Zuchowski, Steve
Gibson, Richard T.
TI Pathways to a Career in Military Psychiatry
SO ACADEMIC PSYCHIATRY
LA English
DT Editorial Material
ID DEPLOYMENT
C1 [Diebold, Carroll J.; Leong, Stephanie L.; Gibson, Richard T.] Tripler Army Med Ctr, Honolulu, HI 96859 USA.
[Zuchowski, Steve] Univ Nevada, Sch Med, Reno, NV 89557 USA.
RP Diebold, CJ (reprint author), Tripler Army Med Ctr, Honolulu, HI 96859 USA.
EM carroll.j.diebold.mil@mail.mil
NR 21
TC 0
Z9 0
U1 1
U2 1
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1042-9670
EI 1545-7230
J9 ACAD PSYCHIATR
JI Acad. Psych.
PD AUG
PY 2015
VL 39
IS 4
BP 402
EP 409
DI 10.1007/s40596-015-0368-z
PG 8
WC Education & Educational Research; Psychiatry
SC Education & Educational Research; Psychiatry
GA CR1OA
UT WOS:000361093500012
PM 26059738
ER
PT J
AU Capaldi, VF
Zembrzuska, HD
AF Capaldi, Vincent F., II
Zembrzuska, Hanna D.
TI Thrust Into the Breach: Psychiatry in a Combat Zone Within 1 Year of
Residency Completion
SO ACADEMIC PSYCHIATRY
LA English
DT Editorial Material
C1 [Capaldi, Vincent F., II] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA.
[Zembrzuska, Hanna D.] Walter Reed Natl Mil Med Ctr, Bethesda, MD USA.
RP Capaldi, VF (reprint author), Walter Reed Army Inst Res, Silver Spring, MD 20910 USA.
EM vin@capaldi.org
NR 7
TC 1
Z9 1
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1042-9670
EI 1545-7230
J9 ACAD PSYCHIATR
JI Acad. Psych.
PD AUG
PY 2015
VL 39
IS 4
BP 410
EP 415
DI 10.1007/s40596-015-0283-3
PG 6
WC Education & Educational Research; Psychiatry
SC Education & Educational Research; Psychiatry
GA CR1OA
UT WOS:000361093500013
PM 25636255
ER
PT J
AU Tagliente, DA
Lyding, C
Zawislak, J
Marston, D
AF Tagliente, Daniel A.
Lyding, Charles
Zawislak, Joshua
Marston, Derek
TI Expanding Emulation from Test to Create Realistic Virtual Training
Environments
SO IEEE INSTRUMENTATION & MEASUREMENT MAGAZINE
LA English
DT Article
C1 [Tagliente, Daniel A.; Lyding, Charles; Marston, Derek] US Army, Automated Test Syst Div, Armament Res Dev & Engn Ctr, Picatinny Arsenal, NJ 07806 USA.
RP Tagliente, DA (reprint author), US Army, Automated Test Syst Div, Armament Res Dev & Engn Ctr, Picatinny Arsenal, NJ 07806 USA.
EM daniel.a.tagliente.civ@mail.mil
NR 5
TC 0
Z9 0
U1 0
U2 0
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 1094-6969
EI 1941-0123
J9 IEEE INSTRU MEAS MAG
JI IEEE Instrum. Meas. Mag.
PD AUG
PY 2015
VL 18
IS 4
BP 53
EP 57
PG 5
WC Engineering, Electrical & Electronic; Instruments & Instrumentation
SC Engineering; Instruments & Instrumentation
GA CR1EL
UT WOS:000361066600012
ER
PT J
AU Redding, B
Schwab, MJ
Pan, YL
AF Redding, Brandon
Schwab, Mark J.
Pan, Yong-le
TI Raman Spectroscopy of Optically Trapped Single Biological
Micro-Particles
SO SENSORS
LA English
DT Review
DE optical trapping; Raman spectroscopy; bioaerosols
ID RED-BLOOD-CELLS; INDIVIDUAL BACILLUS SPORES; LASER TWEEZERS; ABSORBING
PARTICLES; AEROSOL DROPLETS; LIVING CELLS; RADIATION PRESSURE;
BACTERIAL-SPORES; PHOTOPHORETIC FORCES; MULTIPLE PARTICLES
AB The combination of optical trapping with Raman spectroscopy provides a powerful method for the study, characterization, and identification of biological micro-particles. In essence, optical trapping helps to overcome the limitation imposed by the relative inefficiency of the Raman scattering process. This allows Raman spectroscopy to be applied to individual biological particles in air and in liquid, providing the potential for particle identification with high specificity, longitudinal studies of changes in particle composition, and characterization of the heterogeneity of individual particles in a population. In this review, we introduce the techniques used to integrate Raman spectroscopy with optical trapping in order to study individual biological particles in liquid and air. We then provide an overview of some of the most promising applications of this technique, highlighting the unique types of measurements enabled by the combination of Raman spectroscopy with optical trapping. Finally, we present a brief discussion of future research directions in the field.
C1 [Redding, Brandon; Schwab, Mark J.; Pan, Yong-le] US Army Res Lab, Adelphi, MD 20783 USA.
RP Pan, YL (reprint author), US Army Res Lab, 2800 Powder Mill Rd, Adelphi, MD 20783 USA.
EM redding.brandon@gmail.com; mark.schwab@yale.edu; yongle.pan.civ@mail.mil
FU Defense Threat Reduction Agency (DTRA) [HDTRA 1514122, HDTRA1310184]; US
Army Research Laboratory mission funds; [W911NF-12-2-0019]
FX We acknowledge support by the Defense Threat Reduction Agency (DTRA)
under contract number HDTRA 1514122 and HDTRA1310184, US Army Research
Laboratory mission funds, and under Cooperative Agreement Number
W911NF-12-2-0019.
NR 106
TC 4
Z9 5
U1 14
U2 43
PU MDPI AG
PI BASEL
PA POSTFACH, CH-4005 BASEL, SWITZERLAND
SN 1424-8220
J9 SENSORS-BASEL
JI Sensors
PD AUG
PY 2015
VL 15
IS 8
BP 19021
EP 19046
DI 10.3390/s150819021
PG 26
WC Chemistry, Analytical; Electrochemistry; Instruments & Instrumentation
SC Chemistry; Electrochemistry; Instruments & Instrumentation
GA CQ9BS
UT WOS:000360906500062
PM 26247952
ER
PT J
AU Savoie, FA
Kenefick, RW
Ely, BR
Cheuvront, SN
Goulet, EDB
AF Savoie, Felix-Antoine
Kenefick, Robert W.
Ely, Brett R.
Cheuvront, Samuel N.
Goulet, Eric D. B.
TI Effect of Hypohydration on Muscle Endurance, Strength, Anaerobic Power
and Capacity and Vertical Jumping Ability: A Meta-Analysis
SO SPORTS MEDICINE
LA English
DT Review
ID EXERCISE-INDUCED DEHYDRATION; NEUROMUSCULAR FUNCTION; MODERATE
DEHYDRATION; MUSCULAR STRENGTH; FORCE PRODUCTION; TIME-TRIAL;
PERFORMANCE; WEIGHT; HYDRATION; ACTIVATION
AB Background How hypohydration impacts non-body-weight (BW)-dependent muscle performance and vertical jumping ability remains to be determined using meta-analytic procedures.
Objectives Our objective was to determine the impact of hypohydration on muscle endurance, strength, anaerobic power and capacity and vertical jumping ability using a meta-analytic approach.
Data sources Studies were located using database searches and cross-referencing.
Synthesis methods Effect summaries were obtained using random-effects models; method of moments mixed-effects analysis-of-variance-like procedures were used to determine differences between groups; and restricted maximum likelihood random-effects meta-regressions were performed to determine relationships between variables, impact of confounders, and interaction effects.
Results A total of 28 manuscripts met the inclusion criteria, producing six (upper body muscle endurance), ten (lower body muscle endurance), 14 (upper body muscle strength), 25 (lower body muscle strength), nine (muscle anaerobic power), nine (muscle anaerobic capacity), and 12 (vertical jumping ability) effect estimates. Hypohydration impaired overall muscle endurance by 8.3 +/- 2.3 % (P < 0.05), with no significant difference between upper body (-8.4 +/- 3.3 %) and lower body (-8.2 +/- 3.2 %). As a whole, muscle strength fell by 5.5 +/- 1.0 % (P < 0.05) with hypohydration; the difference between lower (-3.7 +/- 1.8 %) and upper (-6.2 +/- 1.1 %) body was nonsignificant. Anaerobic power (-5.8 +/- 2.3 %) was significantly altered with hypohydration, but anaerobic capacity (-3.5 +/- 2.3 %) and vertical jumping ability (0.9 +/- 0.7 %) were not. No significant correlations were observed between the changes in any of the muscle performance variables or vertical jumping ability and the changes in hypohydration level. Using an active procedure to dehydrate participants decreased muscle performance by an additional 5.4 +/- 1.9 % (2.76-fold) (P = 0.02) compared with using a passive dehydration procedure. Trained individuals demonstrated a 3.3 +/- 1.7 % (1.76-fold) (P = 0.06) lesser decrease in muscle performance with hypohydration than did untrained individuals.
Conclusion Hypohydration, or factors associated with dehydration, are likely to be associated with practically important decrements in muscle endurance, strength, and anaerobic power and capacity. However, their impact on non-BW-dependent muscle performance is substantially mitigated in trained individuals or when hypohydration is induced passively. Conversely, it is possible that body water loss (similar to 3 % BW) may improve performance in BW-dependent tasks such as vertical jumping ability.
C1 [Savoie, Felix-Antoine; Goulet, Eric D. B.] Univ Sherbrooke, Fac Phys Act Sci, Sherbrooke, PQ J1K 2R1, Canada.
[Savoie, Felix-Antoine; Goulet, Eric D. B.] Univ Sherbrooke, Res Ctr Aging, Sherbrooke, PQ J1H 4C4, Canada.
[Kenefick, Robert W.; Ely, Brett R.; Cheuvront, Samuel N.] US Army, Environm Med Res Inst, Natick, MA 01760 USA.
[Ely, Brett R.] Univ Oregon, Dept Human Physiol, Eugene, OR 97403 USA.
RP Goulet, EDB (reprint author), Univ Sherbrooke, Fac Phys Act Sci, 2500 Boul Univ, Sherbrooke, PQ J1K 2R1, Canada.
EM eric.goulet@usherbrooke.ca
NR 51
TC 1
Z9 1
U1 16
U2 36
PU ADIS INT LTD
PI NORTHCOTE
PA 5 THE WAREHOUSE WAY, NORTHCOTE 0627, AUCKLAND, NEW ZEALAND
SN 0112-1642
EI 1179-2035
J9 SPORTS MED
JI Sports Med.
PD AUG
PY 2015
VL 45
IS 8
BP 1207
EP 1227
DI 10.1007/s40279-015-0349-0
PG 21
WC Sport Sciences
SC Sport Sciences
GA CR6VH
UT WOS:000361485500010
PM 26178327
ER
PT J
AU Graham, BS
Modjarrad, K
McLellan, JS
AF Graham, Barney S.
Modjarrad, Kayvon
McLellan, Jason S.
TI Novel antigens for RSV vaccines
SO CURRENT OPINION IN IMMUNOLOGY
LA English
DT Review
ID RESPIRATORY SYNCYTIAL VIRUS; SMALL HYDROPHOBIC PROTEIN;
FORMALIN-INACTIVATED RSV; FUSION GLYCOPROTEIN; SUBUNIT VACCINE;
F-PROTEIN; NEUTRALIZING ANTIBODY; ENHANCED DISEASE; MONOCLONAL-ANTIBODY;
STRUCTURAL BASIS
AB Respiratory syncytial virus (RSV) remains a leading global cause of infant mortality and adult morbidity. Infection, which recurs throughout life, elicits only short-lived immunity. The development of a safe and efficacious vaccine has, thus far, been elusive. Recent technological advances, however, have yielded promising RSV vaccine candidates that are based on solving atomic-level structures of surface glycoproteins interacting with neutralizing antibodies. The class I fusion glycoprotein, F, serves as the primary antigenic component of most vaccines, and is the target of the only licensed monoclonal antibody product used to reduce the frequency of severe disease in high-risk neonates. However, success of prior F-based vaccines has been limited by the lack of understanding how the conformational rearrangement between a metastable prefusion F (pre-F) and a stable postfusion F (post-F) affected the epitope content. Neutralizing epitopes reside on both conformations, but those specific to pre-F are far more potent than those previously identified and present on post-F. The solution of the pre-F structure and its subsequent characterization and stabilization illustrates the value of a structure-based approach to vaccine development, and provides hope that a safe and effective RSV vaccine is possible.
C1 [Graham, Barney S.] NIAID, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA.
[Modjarrad, Kayvon] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA.
[Modjarrad, Kayvon] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA.
[McLellan, Jason S.] Geisel Sch Med Dartmouth, Dept Biochem, Hanover, NH 03755 USA.
RP Graham, BS (reprint author), NIAID, Vaccine Res Ctr, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA.
EM bgraham@nih.gov
FU intramural program of the National Institute of Allergy and Infectious
Diseases; NIAID [1R43AI112124]
FX B.S.G. and K.M. were supported by funding from the intramural program of
the National Institute of Allergy and Infectious Diseases. J.S.M. was
supported in part by NIAID grant 1R43AI112124.
NR 63
TC 12
Z9 14
U1 8
U2 12
PU CURRENT BIOLOGY LTD
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 0952-7915
EI 1879-0372
J9 CURR OPIN IMMUNOL
JI Curr. Opin. Immunol.
PD AUG
PY 2015
VL 35
BP 30
EP 38
DI 10.1016/j.coi.2015.04.005
PG 9
WC Immunology
SC Immunology
GA CR1HB
UT WOS:000361074400007
PM 26070108
ER
PT J
AU Hulla, JE
Kinter, LB
Kelman, B
AF Hulla, Janis E.
Kinter, Lewis B.
Kelman, Bruce
TI A Standard of Knowledge for the Professional Practice of Toxicology
SO ENVIRONMENTAL HEALTH PERSPECTIVES
LA English
DT Article
AB BACKGROUND: Employers, courts, and the general public judge the credibility of professionals based on credentials such as academic degrees, publications, memberships in professional organizations, board certifications, and professional registrations. However, the relevance and merit of these credentials can be difficult to determine objectively. Board certification can be a reliable indicator of proficiency if the certifying organization demonstrates, through regularly scheduled independent review, that its processes meet established standards and when a certificate holder is required to periodically demonstrate command of a body of knowledge that is essential to current professional practice.
OBJECTIVE: We report herein a current Standard of Knowledge in general toxicology compiled from the experience and opinions of 889 certified practicing professional toxicologists.
DISCUSSION: An examination is the most commonly used instrument for testing a certification candidate's command of the body of knowledge. However, an examination-based certification is only creditable when the body of knowledge, to which a certification examination tests, is representative of the current knowledge, skills, and capabilities needed to effectively practice at the professional level. Thus, that body of knowledge must be the current "Standard of Knowledge" for the profession, compiled in a transparent fashion from current practitioners of the profession.
CONCLUSION: This work was conducted toward ensuring the scientific integrity of the products produced by professional toxicologists.
C1 [Hulla, Janis E.] US Army Corps Engineers, Environm Engn Branch, Sacramento, CA 95814 USA.
[Kinter, Lewis B.] AstraZeneca, Drug Safety & Metab, Wilmington, DE USA.
[Kelman, Bruce] Veritox Inc, Redmond, WA USA.
RP Hulla, JE (reprint author), US Army Corps Engineers, 1325 J St,ED-E, Sacramento, CA 95814 USA.
EM Janis.E.Hulla@usace.army.mil
NR 9
TC 1
Z9 1
U1 0
U2 7
PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
PI RES TRIANGLE PK
PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233,
RES TRIANGLE PK, NC 27709-2233 USA
SN 0091-6765
EI 1552-9924
J9 ENVIRON HEALTH PERSP
JI Environ. Health Perspect.
PD AUG
PY 2015
VL 123
IS 8
BP 743
EP 748
DI 10.1289/ehp.1408643
PG 6
WC Environmental Sciences; Public, Environmental & Occupational Health;
Toxicology
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
Health; Toxicology
GA CQ6CX
UT WOS:000360693100014
PM 25782181
ER
PT J
AU Jardins, TD
Drone, SA
Hashisaka, S
Hazzard, J
Hunt, SB
Massey, K
Rein, A
Schachter, A
Turske, S
AF Jardins, Terrisca Des
Drone, Shenetta A.
Hashisaka, Susan
Hazzard, Jobyna
Hunt, Susan B.
Massey, Kimberly
Rein, Alison
Schachter, Abigail
Turske, Scott
TI Patient Engagement and Activation in Three Underserved Beacon
Communities
SO JOURNAL OF HEALTH CARE FOR THE POOR AND UNDERSERVED
LA English
DT Article
DE Patient engagement; patient activation; health IT; health disparities;
mHealth; telemedicine; access to health care; cultural competency
ID DIABETES RISK AWARENESS; TEXT MESSAGE PROGRAM; HEALTH-CARE; PERCEPTIONS;
NEEDS
AB Whether the setting is urban, rural, or somewhere in between, engagement strategies for the underserved require a great deal of flexibility and sensitivity to the socioeconomic, cultural, and geographic conditions of the patient population. The following report details how three unique communities designed specific strategies to engage underserved populations in the management of their chronic conditions.
C1 [Jardins, Terrisca Des; Turske, Scott] Southeast Michigan Beacon Community, Detroit, MI USA.
[Drone, Shenetta A.; Hazzard, Jobyna; Massey, Kimberly] Delta Hlth Alliance, Wageningen, Netherlands.
[Hashisaka, Susan] Southeast Michigan Beacon Community, Clin Transformat, Detroit, MI USA.
[Hunt, Susan B.] Hawaii Isl Beacon Community, Schofield Barracks, HI USA.
[Rein, Alison; Schachter, Abigail] AcademyHealth, Washington, DC USA.
RP Rein, A (reprint author), 1150 17th St NW,Suite 600, Washington, DC 20036 USA.
NR 16
TC 0
Z9 0
U1 0
U2 6
PU JOHNS HOPKINS UNIV PRESS
PI BALTIMORE
PA JOURNALS PUBLISHING DIVISION, 2715 NORTH CHARLES ST, BALTIMORE, MD
21218-4363 USA
SN 1049-2089
EI 1548-6869
J9 J HEALTH CARE POOR U
JI J. Health Care Poor Underserved
PD AUG
PY 2015
VL 26
IS 3
BP 777
EP 783
DI 10.1353/hpu.2015.0084
PG 7
WC Health Policy & Services; Public, Environmental & Occupational Health
SC Health Care Sciences & Services; Public, Environmental & Occupational
Health
GA CQ9EP
UT WOS:000360915400016
PM 26320912
ER
PT J
AU Albert, DG
Swearingen, ME
Perron, FE
Carbee, DL
AF Albert, Donald G.
Swearingen, Michelle E.
Perron, Frank E., Jr.
Carbee, David L.
TI Low frequency acoustic pulse propagation in temperate forests
SO JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
LA English
DT Article
ID REVERBERATION TIME; SOUND-PROPAGATION; FLOW RESISTIVITY; TREE BELTS;
ATTENUATION; ABSORPTION; VEGETATION; ROUGHNESS; IMPEDANCE; SURFACES
AB Measurements of acoustic pulse propagation for a 30-m path were conducted in an open field and in seven different forest stands in the northeastern United States consisting of deciduous, evergreen, or mixed tree species. The waveforms recorded in forest generally show the pulse elongation characteristic of propagation over a highly porous ground surface, with high frequency scattered arrivals superimposed on the basic waveform shape. Waveform analysis conducted to determine ground properties resulted in acoustically determined layer thicknesses of 4-8 cm in summer, within 2 cm of the directly measured thickness of the litter layers. In winter the acoustic thicknesses correlated with the site-specific snow cover depths. Effective flow resistivity values of 50-88 kN s m(-4) were derived for the forest sites in summer, while lower values typical for snow were found in winter. Reverberation times (T60) were typically around 2 s, but two stands (deciduous and pruned spruce planted on a square grid) had lower values of about 1.2 s. One site with a very rough ground surface had very low summer flow resistivity value and also had the longest reverberation time of about 3 s. These measurements can provide parameters useful for theoretical predictions of acoustic propagation within forests.
C1 [Albert, Donald G.] US Army Engn Res & Dev Ctr, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA.
[Swearingen, Michelle E.] US Army Engn Res & Dev Ctr, Construct Engn Res Lab, Champaign, IL 61822 USA.
[Perron, Frank E., Jr.; Carbee, David L.] US Army Engn Res & Dev Ctr, Cold Reg Res & Engn Lab, Hanover, NH 03755 USA.
RP Albert, DG (reprint author), US Army Engn Res & Dev Ctr, Cold Reg Res & Engn Lab, 72 Lyme Rd, Hanover, NH 03755 USA.
EM Donald.G.Albert@usace.army.mil
FU ERDC basic research program
FX This research was funded by the ERDC basic research program. We thank
Steve Decato (retired) of ERDC-CRREL for assistance with the field
experiments themselves and for snow characterization. We also thank Mr.
Leon Stetson for use of his land in Vermont, and two anonymous reviewers
for useful comments that improved the manuscript. (Distribution
Statement A-Approved for public release; distribution unlimited.)
NR 43
TC 0
Z9 0
U1 2
U2 4
PU ACOUSTICAL SOC AMER AMER INST PHYSICS
PI MELVILLE
PA STE 1 NO 1, 2 HUNTINGTON QUADRANGLE, MELVILLE, NY 11747-4502 USA
SN 0001-4966
EI 1520-8524
J9 J ACOUST SOC AM
JI J. Acoust. Soc. Am.
PD AUG
PY 2015
VL 138
IS 2
BP 735
EP 747
DI 10.1121/1.4923365
PG 13
WC Acoustics; Audiology & Speech-Language Pathology
SC Acoustics; Audiology & Speech-Language Pathology
GA CQ5NV
UT WOS:000360652900029
PM 26328690
ER
PT J
AU Pasiakos, SM
Agarwal, S
Lieberman, HR
Fulgoni, VL
AF Pasiakos, Stefan M.
Agarwal, Sanjiv
Lieberman, Harris R.
Fulgoni, Victor L., III
TI Sources and Amounts of Animal, Dairy, and Plant Protein Intake of US
Adults in 2007-2010
SO NUTRIENTS
LA English
DT Article
ID NUTRITION EXAMINATION SURVEY; NUTRIENT ADEQUACY; NATIONAL-HEALTH; DIETS;
FOODS
AB Dietary guidelines suggest consuming a mixed-protein diet, consisting of high-quality animal, dairy, and plant-based foods. However, current data on the distribution and the food sources of protein intake in a free-living, representative sample of US adults are not available. Data from the National Health and Nutrition Examination Survey (NHANES), 2007-2010, were used in these analyses (n = 10,977, age >= 19 years). Several US Department of Agriculture (USDA) databases were used to partition the composition of foods consumed into animal, dairy, or plant components. Mean +/- SE animal, dairy, and plant protein intakes were determined and deciles of usual intakes were estimated. The percentages of total protein intake derived from animal, dairy, and plant protein were 46%, 16%, and 30%, respectively; 8% of intake could not be classified. Chicken and beef were the primary food sources of animal protein intake. Cheese, reduced-fat milk, and ice cream/dairy desserts were primary sources of dairy protein intake. Yeast breads, rolls/buns, and nuts/seeds were primary sources of plant protein intake. This study provides baseline data for assessing the effectiveness of public health interventions designed to alter the composition of protein foods consumed by the American public.
C1 [Pasiakos, Stefan M.; Lieberman, Harris R.] US Army, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA.
[Agarwal, Sanjiv] Oak Ridge Inst Sci & Educ, Belcamp, MD 21017 USA.
[Agarwal, Sanjiv] NutriScience LLC, East Norriton, PA 19403 USA.
[Fulgoni, Victor L., III] Henry M Jackson Fdn, Bethesda, MD 20817 USA.
[Fulgoni, Victor L., III] Nutr Impact LLC, Battle Creek, MI 49014 USA.
RP Pasiakos, SM (reprint author), US Army, Environm Med Res Inst, Mil Nutr Div, Natick, MA 01760 USA.
EM stefan.m.pasiakos.civ@mail.mil; agarwal47@yahoo.com;
harris.r.lieberman.civ@mail.mil; VIC3RD@aol.com
RI Pasiakos, Stefan/E-6295-2014
OI Pasiakos, Stefan/0000-0002-5378-5820
FU US Army Military Research and Material Command; Department of Defense
Center Alliance for Nutrition and Dietary Supplements Research
FX This research was supported by the US Army Military Research and
Material Command and the Department of Defense Center Alliance for
Nutrition and Dietary Supplements Research.
NR 13
TC 4
Z9 4
U1 2
U2 10
PU MDPI AG
PI BASEL
PA POSTFACH, CH-4005 BASEL, SWITZERLAND
SN 2072-6643
J9 NUTRIENTS
JI Nutrients
PD AUG
PY 2015
VL 7
IS 8
BP 7058
EP 7069
DI 10.3390/nu7085322
PG 12
WC Nutrition & Dietetics
SC Nutrition & Dietetics
GA CQ4PQ
UT WOS:000360587500055
PM 26308049
ER
PT J
AU McWhirter, KK
Morrow, AS
Lee, BA
Bishu, S
Zametkin, AJ
Balkin, TJ
Smith, CB
Picchioni, D
AF McWhirter, Kelly K.
Morrow, Anne S.
Lee, Beth A.
Bishu, Shrinivas
Zametkin, Alan J.
Balkin, Thomas J.
Smith, Carolyn B.
Picchioni, Dante
TI A PILOT STUDY ON THE ENCODING OF A PERCEPTUAL LEARNING TASK FOLLOWING
SLEEP DEPRIVATION
SO PERCEPTUAL AND MOTOR SKILLS
LA English
DT Article
ID DISCRIMINATION; MEMORY; DETERIORATION; IMPROVEMENT; PLASTICITY; BENEFITS
AB Memory encoding sometimes must occur during a period of sleep deprivation. The question was whether one night of sleep deprivation inhibits encoding on a perceptual learning task (the texture discrimination task). The sample was 18 human participants (M age = 22.1 yr., SEM = 0.5; 8 men). The participants were randomized to a sleep deprivation or sleep control condition and, after the manipulation, were given two administrations of the texture discrimination task. All participants were given an opportunity for a 90 min. nap between the two administrations. Performance was measured by the interpolated stimulus-to-mask-onset asynchrony (i.e., the inter-stimulus interval), at which the percentage of correct responses for the stimuli in the participant's peripheral vision fell below 80%. Offline consolidation was defined as a decrease in this index between the two administrations. Participants who were sleep deprived prior to encoding exhibited similar offline consolidation (M = -5.3 msec., SEM = 2.3) compared to participants who were not sleep deprived prior to encoding (M = -6.2 msec., SEM = 3.9); the two-way interaction between time and condition was not significant. In light of reports in the literature, these results indicate encoding following sleep deprivation may be influenced by both the type of task encoded and the brain regions involved in memory processing.
C1 [McWhirter, Kelly K.; Balkin, Thomas J.; Picchioni, Dante] Walter Reed Army Inst Res, Silver Spring, MD USA.
[Morrow, Anne S.; Lee, Beth A.; Bishu, Shrinivas; Zametkin, Alan J.; Smith, Carolyn B.] NIH, Bethesda, MD 20892 USA.
RP Picchioni, D (reprint author), NIH, Intramural Res Program, 10 Ctr Dr, Bethesda, MD 20892 USA.
EM dante.picchioni@nih.gov
FU National Institute of Mental Health Intramural Research Program; U.S.
Army Medical Research and Materiel Command
FX This research was supported by the National Institute of Mental Health
Intramural Research Program and the U.S. Army Medical Research and
Materiel Command. The views expressed in this article are those of the
authors and do not necessarily reflect the official policy or position
of the Department of the Army nor the U.S. Government. The
ClinicalTrials.gov Identifier is NCT00884702, and the National
Institutes of Health Institutional Review Board Protocol Number is
09-M-0123.
NR 25
TC 0
Z9 0
U1 1
U2 5
PU AMMONS SCIENTIFIC, LTD
PI MISSOULA
PA PO BOX 9229, MISSOULA, MT 59807-9229 USA
SN 0031-5125
J9 PERCEPT MOTOR SKILL
JI Percept. Mot. Skills
PD AUG
PY 2015
VL 121
IS 1
BP 80
EP 93
DI 10.2466/23.PMS.121c11x9
PG 14
WC Psychology, Experimental
SC Psychology
GA CQ9PH
UT WOS:000360946600006
PM 26226287
ER
PT J
AU Turell, MJ
AF Turell, Michael J.
TI Experimental Transmission of Karshi (Mammalian Tick-Borne Flavivirus
Group) Virus by Ornithodoros Ticks > 2,900 Days after Initial Virus
Exposure Supports the Role of Soft Ticks as a Long-Term Maintenance
Mechanism for Certain Flaviviruses
SO PLOS NEGLECTED TROPICAL DISEASES
LA English
DT Article
ID HEMORRHAGIC-FEVER VIRUS; FOREST DISEASE VIRUS; ENCEPHALITIS-VIRUS;
SONRAI ACARI; ARGASIDAE; COMPLEX; TAXONOMY; BIOLOGY; VIREMIA; HOSTS
AB Background
Members of the mammalian tick-borne flavivirus group, including tick-borne encephalitis virus, are responsible for at least 10,000 clinical cases of tick-borne encephalitis each year. To attempt to explain the long-term maintenance of members of this group, we followed Ornithodoros parkeri, O. sonrai, and O. tartakovskyi for > 2,900 days after they had been exposed to Karshi virus, a member of the mammalian tick-borne flavivirus group.
Methodology/Principal Findings
Ticks were exposed to Karshi virus either by allowing them to feed on viremic suckling mice or by intracoelomic inoculation. The ticks were then allowed to feed individually on suckling mice after various periods of extrinsic incubation to determine their ability to transmit virus by bite and to determine how long the ticks would remain infectious. The ticks remained efficient vectors of Karshi virus, even when tested > 2,900 d after their initial exposure to virus, including those ticks exposed to Karshi virus either orally or by inoculation.
Conclusions/Significance
Ornithodoros spp. ticks were able to transmit Karshi virus for > 2,900 days (nearly 8 years) after a single exposure to a viremic mouse. Therefore, these ticks may serve as a long-term maintenance mechanism for Karshi virus and potentially other members of the mammalian tick-borne flavivirus group.
C1 US Army Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21701 USA.
RP Turell, MJ (reprint author), US Army Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21701 USA.
EM michael.j.turell@us.army.mil
FU Defense Threat Reduction Agency's Threat Agent Detection and Response
program under USAMRIID [188403]; Military Infectious Diseases Research
Program under USAMRIID [1884676]
FX The original project was funded by by the Defense Threat Reduction
Agency's Threat Agent Detection and Response program, carried out under
USAMRIID project number 188403, and the later portions of this study
were funded by the Military Infectious Diseases Research Program,
carried out under USAMRIID project number 1884676. The funders had no
role in study design, data collection and analysis, decision to publish,
or preparation of the manuscript.
NR 40
TC 2
Z9 2
U1 1
U2 3
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1935-2735
J9 PLOS NEGLECT TROP D
JI Plos Neglect. Trop. Dis.
PD AUG
PY 2015
VL 9
IS 8
AR e0004012
DI 10.1371/journal.pntd.0004012
PG 8
WC Infectious Diseases; Parasitology; Tropical Medicine
SC Infectious Diseases; Parasitology; Tropical Medicine
GA CQ6IO
UT WOS:000360708200032
PM 26285211
ER
PT J
AU Westby, SR
Bruce, D
Gross, K
Lazar, J
Muzia, K
Paynter, K
Sowers, A
Slacum, W
Townsend, H
Weissberger, E
AF Westby, Stephanie Reynolds
Bruce, David
Gross, Kimberly
Lazar, Jay
Muzia, Kara
Paynter, Ken
Sowers, Angela
Slacum, Ward
Townsend, Howard
Weissberger, Eric
TI LARGE-SCALE OYSTER RESTORATION IN CHESAPEAKE BAY
SO JOURNAL OF SHELLFISH RESEARCH
LA English
DT Meeting Abstract
C1 [Westby, Stephanie Reynolds; Bruce, David; Lazar, Jay; Townsend, Howard] NOAA, Annapolis, MD 21403 USA.
[Gross, Kimberly; Sowers, Angela] US Army Corps Engineers, Baltimore, MD 21202 USA.
[Muzia, Kara; Slacum, Ward] Oyster Recovery Partnership, Annapolis, MD 21401 USA.
[Paynter, Ken] Univ Maryland, Marine Environm & Estuarine Program, College Pk, MD 20742 USA.
[Weissberger, Eric] Maryland Dept Nat Resources, Fisheries Serv, Annapolis, MD 21403 USA.
NR 0
TC 0
Z9 0
U1 3
U2 7
PU NATL SHELLFISHERIES ASSOC
PI GROTON
PA C/O DR. SANDRA E. SHUMWAY, UNIV CONNECTICUT, 1080 SHENNECOSSETT RD,
GROTON, CT 06340 USA
SN 0730-8000
EI 1943-6319
J9 J SHELLFISH RES
JI J. Shellfish Res.
PD AUG
PY 2015
VL 34
IS 2
BP 691
EP 691
PG 1
WC Fisheries; Marine & Freshwater Biology
SC Fisheries; Marine & Freshwater Biology
GA CQ2DV
UT WOS:000360410500300
ER
PT J
AU Rose, JM
Bricker, SB
Getchis, T
Chadwick, C
Rose, CM
AF Rose, Julie M.
Bricker, Suzanne B.
Getchis, Tessa
Chadwick, Cary
Rose, Cori M.
TI MERGING, MODELING AND MAPPING TO IMPROVE SHELLFISH AQUACULTURE SITE
SELECTION
SO JOURNAL OF SHELLFISH RESEARCH
LA English
DT Meeting Abstract
C1 [Rose, Julie M.] NOAA, NMFS, Northeast Fisheries Sci Ctr, Milford Lab, Milford, CT USA.
[Bricker, Suzanne B.] NOAA, Natl Ctr Coastal Ocean Sci, Silver Spring, MD 20910 USA.
[Getchis, Tessa] Univ Connecticut, Connecticut Sea Grant, Groton, CT 06340 USA.
[Chadwick, Cary] Univ Connecticut, Ctr Land Use Educ & Res, Haddam, CT 06438 USA.
[Rose, Cori M.] US Army Corps Engineers, Regulatory Div, Concord, MA USA.
NR 0
TC 0
Z9 0
U1 2
U2 3
PU NATL SHELLFISHERIES ASSOC
PI GROTON
PA C/O DR. SANDRA E. SHUMWAY, UNIV CONNECTICUT, 1080 SHENNECOSSETT RD,
GROTON, CT 06340 USA
SN 0730-8000
EI 1943-6319
J9 J SHELLFISH RES
JI J. Shellfish Res.
PD AUG
PY 2015
VL 34
IS 2
BP 720
EP 720
PG 1
WC Fisheries; Marine & Freshwater Biology
SC Fisheries; Marine & Freshwater Biology
GA CQ2DV
UT WOS:000360410500367
ER
PT J
AU Heier, HE
Badloe, J
Bohonek, M
Cap, A
Doughty, H
Korsak, J
Medby, C
Pfaff, RM
Rentas, FJ
Sailliol, A
Schilha, M
Soderstrom, T
AF Heier, Hans Erik
Badloe, John
Bohonek, Milos
Cap, Andrew
Doughty, Heidi
Korsak, Jolanta
Medby, Christian
Pfaff, Roger Mueller
Rentas, Francisco J.
Sailliol, Anne
Schilha, Martina
Soderstrom, Tommy
TI Use of Tranexamic Acid in Bleeding Combat Casualties
SO MILITARY MEDICINE
LA English
DT Editorial Material
ID RANDOMIZED CONTROLLED-TRIAL; TRAUMA PATIENTS; CRASH-2; MATTERS
C1 [Heier, Hans Erik; Medby, Christian] Norwegian Armed Forces Med Serv, N-2058 Sessvollmoen, Norway.
[Badloe, John] Hlth Care Agcy, Minist Def, Support Command, NL-2509 LS The Hague, Netherlands.
[Bohonek, Milos] Mil Univ Hosp, Cent Mil Hosp, Dept Hematol & Blood Transfus, Prague, Czech Republic.
[Cap, Andrew] US Army Inst Surg Res, Blood Res, San Antonio, TX 78234 USA.
[Cap, Andrew] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
[Cap, Andrew] San Antonio Mil Med Ctr, Jbsa Ft Sam Houston, TX 78234 USA.
[Doughty, Heidi] NHS Blood & Transplant, Birmingham B15 2SG, W Midlands, England.
[Korsak, Jolanta] Mil Inst Med, Dept Clin Transfusiol, Warsaw, Poland.
[Pfaff, Roger Mueller] German Armed Forces Ulm, Mil Hosp, Pharm, D-89081 Ulm, Germany.
[Rentas, Francisco J.] Joint Pathol Ctr, Tissue Repository Operat, Res, Educ, Silver Spring, MD 20910 USA.
[Sailliol, Anne] CTSA Jean Julliard, F-92141 Clamart, France.
[Schilha, Martina] Bundeswehr Med Serv Acad, Div E, Mil Med Res & Dev, D-80939 Munich, Germany.
[Soderstrom, Tommy] Karolinska Univ Hosp, S-17176 Stockholm, Sweden.
RP Heier, HE (reprint author), Norwegian Armed Forces Med Serv, N-2058 Sessvollmoen, Norway.
NR 13
TC 1
Z9 1
U1 1
U2 2
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD AUG
PY 2015
VL 180
IS 8
BP 844
EP 846
DI 10.7205/MILMED-D-14-00592
PG 3
WC Medicine, General & Internal
SC General & Internal Medicine
GA CQ3TE
UT WOS:000360524800006
PM 26226523
ER
PT J
AU Fisher, AD
Miles, EA
Cap, AP
Strandenes, G
Kane, SF
AF Fisher, Andrew D.
Miles, Ethan A.
Cap, Andrew P.
Strandenes, Geir
Kane, Shawn F.
TI Tactical Damage Control Resuscitation
SO MILITARY MEDICINE
LA English
DT Review
ID FRESH WHOLE-BLOOD; COMBAT CASUALTY CARE; SHOCK RESUSCITATION; TRAUMA
PATIENTS; MASSIVE TRANSFUSION; FLUID RESUSCITATION; PLASMA; BATTLEFIELD;
PLATELETS; FUTURE
AB Recently the Committee on Tactical Combat Casualty Care changed the guidelines on fluid use in hemorrhagic shock. The current strategy for treating hemorrhagic shock is based on early use of components: Packed Red Blood Cells (PRBCs), Fresh Frozen Plasma (FFP) and platelets in a 1:1:1 ratio. We suggest that lack of components to mimic whole blood functionality favors the use of Fresh Whole Blood in managing hemorrhagic shock on the battlefield. We present a safe and practical approach for its use at the point of injury in the combat environment called Tactical Damage Control Resuscitation. We describe pre-deployment preparation, assessment of hemorrhagic shock, and collection and transfusion of fresh whole blood at the point of injury. By approaching shock with goal-directed therapy, it is possible to extend the period of survivability in combat casualties.
C1 [Fisher, Andrew D.; Miles, Ethan A.] 75th Ranger Regiment, Ft Benning, GA 31905 USA.
[Cap, Andrew P.] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
[Strandenes, Geir] Norwegian Naval Special Operat Commando, Bergen, Norway.
[Strandenes, Geir] Haukeland Hosp, Dept Immunol & Transfus Med, N-5021 Bergen, Norway.
[Kane, Shawn F.] US Army Special Operat Command, Ft Bragg, NC 28310 USA.
RP Fisher, AD (reprint author), 75th Ranger Regiment, 6420 Dawson Loop, Ft Benning, GA 31905 USA.
RI Fisher, Andrew/M-8683-2015
OI Fisher, Andrew/0000-0003-1994-7774
NR 45
TC 6
Z9 7
U1 2
U2 3
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD AUG
PY 2015
VL 180
IS 8
BP 869
EP 875
DI 10.7205/MILMED-D-14-00721
PG 7
WC Medicine, General & Internal
SC General & Internal Medicine
GA CQ3TE
UT WOS:000360524800012
PM 26226529
ER
PT J
AU Stidham, RA
Garges, EC
Knapp, SA
AF Stidham, Ralph A.
Garges, Eric C.
Knapp, Steven A.
TI Expedited Partner Therapy to Combat Neisseria gonorrhoeae and Chlamydia
trachomatis in Military Populations: Can We Apply This Best Practice?
SO MILITARY MEDICINE
LA English
DT Review
ID SEXUALLY-TRANSMITTED INFECTIONS; UNITED-STATES; ARMY RECRUITS; SEX
PARTNERS; NOTIFICATION; RECURRENT; DISEASES
AB Expedited Partner Therapy (EPT) is the practice of treating the partners of patients with sexually transmitted infections by providing medications for the patient to deliver to his or her sexual partner (s) without direct clinical assessment of the partner(s). EPT is an evidence-based option that can augment existing partner management strategies. For military health care providers, questions still loom as to the pragmatic medical, legal, and ethical uncertainties of EPT use in military populations. These issues, in addition to the absence of an explicit Department of Defense EPT policy may dissuade military clinicians from fully employing EPT to prevent reinfection and inhibit additional disease transmission in their patients. To advance the notion that EPT could not only be an efficient but also a vital measure to decrease the high sexually transmitted disease burden, this report highlights existing approaches utilized by military providers to treat partners of patients diagnosed with chlamydia and/or gonorrhea, benefits of using EPT in military populations, and specific challenges of implementing an EPT program. This report asserts that now is the time to "push the conversation" on the use of EPT as a viable choice for military providers.
C1 [Stidham, Ralph A.] US Army Publ Hlth Command Reg South, Div Epidemiol & Dis Surveillance, Ft Sam Houston, TX 78234 USA.
[Garges, Eric C.] Walter Reed Army Inst Res, Div Prevent Med, Silver Spring, MD 20910 USA.
[Knapp, Steven A.] US Army Publ Hlth Command Reg South, Div Hlth Promot & Wellness, Ft Sam Houston, TX 78234 USA.
RP Stidham, RA (reprint author), US Army Publ Hlth Command Reg South, Div Epidemiol & Dis Surveillance, 2899 Schofield Rd, Ft Sam Houston, TX 78234 USA.
NR 37
TC 0
Z9 0
U1 0
U2 1
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD AUG
PY 2015
VL 180
IS 8
BP 876
EP 881
DI 10.7205/MILMED-D-14-00590
PG 6
WC Medicine, General & Internal
SC General & Internal Medicine
GA CQ3TE
UT WOS:000360524800013
PM 26226530
ER
PT J
AU Sarino, SB
AF Sarino, Shannon Baylis
TI John Paul Jones' Autopsy
SO MILITARY MEDICINE
LA English
DT Editorial Material
C1 US Army Med Res & Mat Command, Amer Registry Pathol, Silver Spring, MD 20910 USA.
RP Sarino, SB (reprint author), US Army Med Res & Mat Command, Amer Registry Pathol, 2500 Linden Lane, Silver Spring, MD 20910 USA.
NR 3
TC 0
Z9 0
U1 0
U2 0
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD AUG
PY 2015
VL 180
IS 8
BP 926
EP 927
DI 10.7205/MILMED-D-15-00120
PG 2
WC Medicine, General & Internal
SC General & Internal Medicine
GA CQ3TE
UT WOS:000360524800020
PM 26226537
ER
PT J
AU Santra, S
Tomaras, GD
Warrier, R
Nicely, NI
Liao, HX
Pollara, J
Liu, PH
Alam, SM
Zhang, RJ
Cocklin, SL
Shen, XY
Duffy, R
Xia, SM
Schutte, RJ
Pemble, CW
Dennison, SM
Li, H
Chao, A
Vidnovic, K
Evans, A
Klein, K
Kumar, A
Robinson, J
Landucci, G
Forthal, DN
Montefiori, DC
Kaewkungwal, J
Nitayaphan, S
Pitisuttithum, P
Rerks-Ngarm, S
Robb, ML
Michael, NL
Kim, JH
Soderberg, KA
Giorgi, EE
Blair, L
Korber, BT
Moog, C
Shattock, RJ
Letvin, NL
Schmitz, JE
Moody, MA
Gao, F
Ferrari, G
Shaw, GM
Haynes, BF
AF Santra, Sampa
Tomaras, Georgia D.
Warrier, Ranjit
Nicely, Nathan I.
Liao, Hua-Xin
Pollara, Justin
Liu, Pinghuang
Alam, S. Munir
Zhang, Ruijun
Cocklin, Sarah L.
Shen, Xiaoying
Duffy, Ryan
Xia, Shi-Mao
Schutte, Robert J.
Pemble, Charles W.
Dennison, S. Moses
Li, Hui
Chao, Andrew
Vidnovic, Kora
Evans, Abbey
Klein, Katja
Kumar, Amit
Robinson, James
Landucci, Gary
Forthal, Donald N.
Montefiori, David C.
Kaewkungwal, Jaranit
Nitayaphan, Sorachai
Pitisuttithum, Punnee
Rerks-Ngarm, Supachai
Robb, Merlin L.
Michael, Nelson L.
Kim, Jerome H.
Soderberg, Kelly A.
Giorgi, Elena E.
Blair, Lily
Korber, Bette T.
Moog, Christiane
Shattock, Robin J.
Letvin, Norman L.
Schmitz, Joern E.
Moody, M. A.
Gao, Feng
Ferrari, Guido
Shaw, George M.
Haynes, Barton F.
TI Human Non-neutralizing HIV-1 Envelope Monoclonal Antibodies Limit the
Number of Founder Viruses during SHIV Mucosal Infection in Rhesus
Macaques
SO PLOS PATHOGENS
LA English
DT Article
ID DEPENDENT CELLULAR CYTOTOXICITY; PROXIMAL EXTERNAL REGION; VACCINE
EFFICACY TRIAL; NEUTRALIZING ANTIBODIES; RECEPTOR-BINDING;
HIV-1-INFECTED INDIVIDUALS; INHIBITORY ANTIBODIES; IMMUNODOMINANT
DOMAIN; MEDIATING ANTIBODIES; EFFECTOR FUNCTION
AB HIV-1 mucosal transmission begins with virus or virus-infected cells moving through mucus across mucosal epithelium to infect CD4(+) T cells. Although broadly neutralizing antibodies (bnAbs) are the type of HIV-1 antibodies that are most likely protective, they are not induced with current vaccine candidates. In contrast, antibodies that do not neutralize primary HIV-1 strains in the TZM-bl infection assay are readily induced by current vaccine candidates and have also been implicated as secondary correlates of decreased HIV-1 risk in the RV144 vaccine efficacy trial. Here, we have studied the capacity of anti-Env monoclonal antibodies (mAbs) against either the immunodominant region of gp41 (7B2 IgG1), the first constant region of gp120 (A32 IgG1), or the third variable loop (V3) of gp120 (CH22 IgG1) to modulate in vivo rectal mucosal transmission of a high-dose simian-human immunodeficiency virus (SHIV-BaL) in rhesus macaques. 7B2 IgG1 or A32 IgG1, each containing mutations to enhance Fc function, was administered passively to rhesus macaques but afforded no protection against productive clinical infection while the positive control antibody CH22 IgG1 prevented infection in 4 of 6 animals. Enumeration of transmitted/founder (T/F) viruses revealed that passive infusion of each of the three antibodies significantly reduced the number of T/F genomes. Thus, some antibodies that bind HIV-1 Env but fail to neutralize virus in traditional neutralization assays may limit the number of T/F viruses involved in transmission without leading to enhancement of viral infection. For one of these mAbs, gp41 mAb 7B2, we provide the first co-crystal structure in complex with a common cyclical loop motif demonstrated to be critical for infection by other retroviruses.
C1 [Santra, Sampa; Cocklin, Sarah L.; Letvin, Norman L.; Schmitz, Joern E.] Harvard Univ, Beth Israel Deaconess Med Ctr, Ctr Virol & Vaccine Res, Sch Med, Boston, MA 02215 USA.
[Tomaras, Georgia D.; Nicely, Nathan I.; Liao, Hua-Xin; Pollara, Justin; Liu, Pinghuang; Alam, S. Munir; Zhang, Ruijun; Shen, Xiaoying; Duffy, Ryan; Xia, Shi-Mao; Schutte, Robert J.; Pemble, Charles W.; Dennison, S. Moses; Kumar, Amit; Montefiori, David C.; Soderberg, Kelly A.; Moody, M. A.; Gao, Feng; Ferrari, Guido; Haynes, Barton F.] Duke Sch Med, Duke Human Vaccine Inst, Durham, NC USA.
[Warrier, Ranjit; Li, Hui; Chao, Andrew; Vidnovic, Kora; Shaw, George M.] Univ Penn, Dept Med, Perelman Sch Med, Philadelphia, PA 19104 USA.
[Evans, Abbey; Klein, Katja; Shattock, Robin J.] Univ London Imperial Coll Sci Technol & Med, Dept Med, London, England.
[Robinson, James] Tulane Univ, Sch Med, Dept Pediat, New Orleans, LA 70112 USA.
[Landucci, Gary; Forthal, Donald N.] Univ Calif Irvine, Dept Med, Div Infect Dis, Irvine, CA 92717 USA.
[Kaewkungwal, Jaranit] Mahidol Univ, Trop Hyg, Bangkok 10700, Thailand.
[Nitayaphan, Sorachai] Armed Forces Res Inst Med Sci, Bangkok 10400, Thailand.
[Pitisuttithum, Punnee] Mahidol Univ, Clin Trop Med, Bangkok 10700, Thailand.
[Rerks-Ngarm, Supachai] Minist Publ Hlth, Dept Dis Control, Nonthaburi, Thailand.
[Robb, Merlin L.; Michael, Nelson L.; Kim, Jerome H.] Walter Reed Army Inst Res, US Mil Res Program, Silver Spring, MD USA.
[Giorgi, Elena E.; Blair, Lily; Korber, Bette T.] Los Alamos Natl Lab, Div Theoret, Los Alamos, NM USA.
[Moog, Christiane] Univ Strasbourg, INSERM, U1109, Strasbourg, Alsace, France.
RP Santra, S (reprint author), Harvard Univ, Beth Israel Deaconess Med Ctr, Ctr Virol & Vaccine Res, Sch Med, Boston, MA 02215 USA.
EM ssantra@bidmc.harvard.edu; gdt@duke.edu; hayne002@mc.duke.edu
RI Moog, Christiane/E-3962-2016; Tomaras, Georgia/J-5041-2016;
OI Moog, Christiane/0000-0002-0916-156X; Korber, Bette/0000-0002-2026-5757
FU National Institutes of Health (NIH/NIAID/ DAIDS): Center for HIV/AIDS
Vaccine Immunology Grant [U01 AI067854]; Bill and Melinda Gates
Foundation [1033098]; NIH/NIAID Reagent Resource Support Program for
AIDS Vaccine Development (Quality Biological, Inc.) [HHSN272201100023C];
Immunology Virology Quality Assessment (IVQA) Center Laboratory Shared
Resource; NIH [AI097315]; U. S. Department of Energy, Office of Science,
Office of Basic Energy Sciences [W-31-109-Eng-38]
FX This work was supported by National Institutes of Health (NIH/NIAID/
DAIDS): Center for HIV/AIDS Vaccine Immunology Grant (U01 AI067854) and
the Collaboration for AIDS Vaccine Discovery Grants from the Bill and
Melinda Gates Foundation (1033098), the NIH/NIAID Reagent Resource
Support Program for AIDS Vaccine Development (Quality Biological, Inc.),
Contract HHSN272201100023C, Immunology Virology Quality Assessment
(IVQA) Center Laboratory Shared Resource, and the NIH grant AI097315.
Crystallography was performed in the Duke University X-ray
Crystallography Shared Resource. Use of the Advanced Photon Source was
supported by the U. S. Department of Energy, Office of Science, Office
of Basic Energy Sciences, under Contract No. W-31-109-Eng-38. SER-CAT
supporting institutions may be found at www.ser-cat.org/members.html.
The views expressed in this manuscript are those of the authors and do
not represent the official views of the Department of the Army or the
Department of Defense. The funders had no role in study design, data
collection and analysis, decision to publish, or preparation of the
manuscript.
NR 120
TC 27
Z9 29
U1 0
U2 6
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1553-7366
EI 1553-7374
J9 PLOS PATHOG
JI PLoS Pathog.
PD AUG
PY 2015
VL 11
IS 8
AR e1005042
DI 10.1371/journal.ppat.1005042
PG 38
WC Microbiology; Parasitology; Virology
SC Microbiology; Parasitology; Virology
GA CQ7VD
UT WOS:000360812500011
PM 26237403
ER
PT J
AU Tuero, I
Mohanram, V
Musich, T
Miller, L
Vargas-Inchaustegui, DA
Demberg, T
Venzon, D
Kalisz, I
Kalyanaraman, VS
Pal, R
Ferrari, MG
LaBranche, C
Montefiori, DC
Rao, M
Vaccari, M
Franchini, G
Barnett, SW
Robert-Guroff, M
AF Tuero, Iskra
Mohanram, Venkatramanan
Musich, Thomas
Miller, Leia
Vargas-Inchaustegui, Diego A.
Demberg, Thorsten
Venzon, David
Kalisz, Irene
Kalyanaraman, V. S.
Pal, Ranajit
Ferrari, Maria Grazia
LaBranche, Celia
Montefiori, David C.
Rao, Mangala
Vaccari, Monica
Franchini, Genoveffa
Barnett, Susan W.
Robert-Guroff, Marjorie
TI Mucosal B Cells Are Associated with Delayed SIV Acquisition in
Vaccinated Female but Not Male Rhesus Macaques Following SIVmac251
Rectal Challenge
SO PLOS PATHOGENS
LA English
DT Article
ID SIMIAN IMMUNODEFICIENCY VIRUS; DEPENDENT CELLULAR CYTOTOXICITY;
ESTROGEN-RECEPTOR-BETA; IMMUNE-RESPONSES; NONHUMAN-PRIMATES;
FC-GLYCOSYLATION; HIV-1 INFECTION; NONNEUTRALIZING ANTIBODIES; ENVELOPE
PROTEIN; SEX-DIFFERENCES
AB Many viral infections, including HIV, exhibit sex-based pathogenic differences. However, few studies have examined vaccine-related sex differences. We compared immunogenicity and protective efficacy of monomeric SIV gp120 with oligomeric SIV gp140 in a pre-clinical rhesus macaque study and explored a subsequent sex bias in vaccine outcome. Each immunization group (16 females, 8 males) was primed twice mucosally with replication-competent Ad-recombinants encoding SIV(smH4)env/rev, SIV(239)gag and SIV(239)nef Delta(1-13) and boosted twice intramuscularly with SIVmac239 monomeric gp120 or oligomeric gp140 in MF59 adjuvant. Controls (7 females, 5 males) received empty Ad and MF59. Up to 9 weekly intrarectal challenges with low-dose SIVmac251 were administered until macaques became infected. We assessed vaccine-induced binding, neutralizing, and non-neutralizing antibodies, Env-specific memory B cells and plasmablasts/plasma cells (PB/PC) in bone marrow and rectal tissue, mucosal Env-specific antibodies, and Env-specific T-cells. Post-challenge, only one macaque (gp140-immunized) remained uninfected. However, SIV acquisition was significantly delayed in vaccinated females but not males, correlated with Env-specific IgA in rectal secretions, rectal Env-specific memory B cells, and PC in rectal tissue. These results extend previous correlations of mucosal antibodies and memory B cells with protective efficacy. The gp140 regimen was more immunogenic, stimulating elevated gp140 and cyclic V2 binding antibodies, ADCC and ADCP activities, bone marrow Env-specific PB/PC, and rectal gp140-specific IgG. However, immunization with gp120, the form of envelope immunogen used in RV144, the only vaccine trial to show some efficacy, provided more significant acquisition delay. Further over 40 weeks of follow-up, no gp120 immunized macaques met euthanasia criteria in contrast to 7 gp140-immunized and 2 control animals. Although males had higher binding antibodies than females, ADCC and ADCP activities were similar. The complex challenge outcomes may reflect differences in IgG subtypes, Fc glycosylation, Fc-R polymorphisms, and/or the microbiome, key areas for future studies. This first demonstration of a sex-difference in SIV vaccine-induced protection emphasizes the need for sex-balancing in vaccine trials. Our results highlight the importance of mucosal immunity and memory B cells at the SIV exposure site for protection.
C1 [Tuero, Iskra; Mohanram, Venkatramanan; Musich, Thomas; Miller, Leia; Vargas-Inchaustegui, Diego A.; Demberg, Thorsten; Robert-Guroff, Marjorie] NCI, Immune Biol Retroviral Infect Sect, Vaccine Branch, NIH, Bethesda, MD 20892 USA.
[Venzon, David] NCI, Biostat & Data Management Sect, NIH, Bethesda, MD 20892 USA.
[Kalisz, Irene; Kalyanaraman, V. S.; Pal, Ranajit; Ferrari, Maria Grazia] Adv Biosci Labs Inc, Rockville, MD USA.
[LaBranche, Celia; Montefiori, David C.] Duke Univ, Med Ctr, Durham, NC USA.
[Rao, Mangala] Walter Reed Army Inst Res, USMHRP, Silver Spring, MD USA.
[Vaccari, Monica; Franchini, Genoveffa] NCI, Anim Models & Retroviral Vaccines Sect, Vaccine Branch, NIH, Bethesda, MD 20892 USA.
[Barnett, Susan W.] Novartis Vaccines, Cambridge, MA USA.
RP Tuero, I (reprint author), NCI, Immune Biol Retroviral Infect Sect, Vaccine Branch, NIH, Bethesda, MD 20892 USA.
EM guroffm@mail.nih.gov
RI Mohanram, Venkatramanan/I-3652-2016
FU NIH [HHSN27201100016C]; NIH grant [5 PO1 AI066287-02]; Intramural
Research Program of the National Institutes of Health, National Cancer
Institute
FX This study was supported in part by NIH contract HHSN27201100016C to
DCM, in part by NIH grant 5 PO1 AI066287-02 to SWB, and in part by the
Intramural Research Program of the National Institutes of Health,
National Cancer Institute. The funders had no role in study design, data
collection and analysis, decision to publish, or preparation of the
manuscript.
NR 79
TC 13
Z9 13
U1 0
U2 1
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1553-7366
EI 1553-7374
J9 PLOS PATHOG
JI PLoS Pathog.
PD AUG
PY 2015
VL 11
IS 8
AR e1005101
DI 10.1371/journal.ppat.1005101
PG 28
WC Microbiology; Parasitology; Virology
SC Microbiology; Parasitology; Virology
GA CQ7VD
UT WOS:000360812500033
PM 26267144
ER
PT J
AU Maurer, BW
Green, RA
Taylor, ODS
AF Maurer, Brett W.
Green, Russell A.
Taylor, Oliver-Denzil S.
TI Moving towards an improved index for assessing liquefaction hazard:
Lessons from historical data
SO SOILS AND FOUNDATIONS
LA English
DT Article
DE Liquefaction; Liquefaction Potential Index; Earthquakes; Ishihara
Boundary Curves; Ishihara-Inspired Index
AB While Liquefaction Potential Index (LPI) has been used to assess liquefaction hazards worldwide, evaluations of LPI during recent earthquakes have found its performance lobe inconsistent. In 1985, Ishihara considered the influence of the non-liquefied surface layer on the manifestation of liquefaction, and proposed an empirical approach to predict liquefaction surface effects. The study presented herein investigates the insights the boundary curves proposed by Ishihara may provide for improving the existing LPI framework. The result of the investigation is a novel Ishihara-inspired index, LPIISH. Its performance is evaluated using select liquefaction case histories and is compared to that of the existing LPI framework. For the selected case studies, LPIISH was found to be consonant With observed surface effects and showed improvement over LPI in mitigating false-positive predictions. Ultimately, the influence of non-liquefiable layers on surficial manifestation is complex, and further research is needed to fully elucidate and quantify these effects. (C) 2015 The Japanese Geotechnical Society. Production and hosting by Elsevier B.V. All rights reserved.
C1 [Maurer, Brett W.; Green, Russell A.] Virginia Tech, Dept Civil & Environm Engn, Blacksburg, VA 24060 USA.
[Taylor, Oliver-Denzil S.] US Army Corps Engn, Engn Res & Dev Ctr, Vicksburg, MS 39180 USA.
RP Green, RA (reprint author), Virginia Tech, Dept Civil & Environm Engn, Blacksburg, VA 24060 USA.
EM rugreen@vt.edu
FU US Army Engineer Research and Development Center (ERDC)
[W912HZ-13-C-0035]; U.S. National Science Foundation (NSF)
[CMMI-1030564, CMMI-1306261, CMMI-1407428, CMMI-1435494]
FX This study is based on work supported by the US Army Engineer Research
and Development Center (ERDC) Grant W912HZ-13-C-0035 and U.S. National
Science Foundation (NSF) Grants CMMI-1030564, CMMI-1306261,
CMMI-1407428, and CMMI-1435494. However, any opinions, findings, and
conclusions or recommendations expressed in this paper are those of the
author and do not necessarily reflect the views of ERDC or NSF.
NR 18
TC 2
Z9 2
U1 0
U2 2
PU JAPANESE GEOTECHNICAL SOC
PI TOKYO
PA SUGAYAMA BLDG 4F, KANDA AWAJI-CHO 2-23, CHIYODA-KU, TOKYO, 101-0063,
JAPAN
SN 0038-0806
J9 SOILS FOUND
JI Soils Found.
PD AUG
PY 2015
VL 55
IS 4
BP 778
EP 787
DI 10.1016/j.sandf.2015.06.010
PG 10
WC Engineering, Geological; Geosciences, Multidisciplinary
SC Engineering; Geology
GA CQ5PN
UT WOS:000360657800009
ER
PT J
AU Polashenski, C
Perovich, DK
Frey, KE
Cooper, LW
Logvinova, CI
Dadic, R
Light, B
Kelly, HP
Trusel, LD
Webster, M
AF Polashenski, Chris
Perovich, Donald K.
Frey, Karen E.
Cooper, Lee W.
Logvinova, Christie I.
Dadic, Ruzica
Light, Bonnie
Kelly, Holly P.
Trusel, Luke D.
Webster, Melinda
TI Physical and morphological properties of sea ice in the Chukchi and
Beaufort Seas during the 2010 and 2011 NASA ICESCAPE missions
SO DEEP-SEA RESEARCH PART II-TOPICAL STUDIES IN OCEANOGRAPHY
LA English
DT Article
DE Sea ice properties; In situ measurements; Arctic zone
ID THICKNESS MEASUREMENTS; SUMMER; VARIABILITY; CIRCULATION; RATES; GROWTH;
STRAIT; WATER; MELT
AB Physical and morphological properties of sea ice in the Chukchi and western Beaufort seas were measured during the 2010 and 2011 June July ICESCAPE (Impacts of Climate on the Eco-Systems and Chemistry of the Arctic Pacific Environment) missions aboard the USCGC Healy. Observations of ice conditions, including ice thicknesses, types, and concentrations of primary, secondary, and tertiary categories were reported at 2-h intervals while the ship was in transit using the Antarctic Sea ice Processes and Climate (ASPeCt) protocol. On-ice surveys of ice thickness, melt-pond depth, and ice properties (including profiles of internal temperature, salinity, and isotopic composition) were conducted at 21 total ice stations (12 in 2010 and 9 in 2011). Comparison to historical ship-based observations confirms a multi-decadal transition from a multiyear to thinner, first year -dominated seasonal sea-ice pack in the region, with much earlier ice retreat than in past decades. The ice encountered was predominantly ( > 98%) first year, with un-deformed ice thicknesses ranging from 0.73 to 1.2 m. Pond coverage was extensive, averaging 29% in 2010 and 19% in 2011, resulting in considerable light absorption in the ice and transmission of light to the ocean. Enhanced melting near the ice edge is consistent with transport of Pacific-origin heat and/or ice-albedo feedbacks. Sediment entrainment was visible in 7.5% and 10.9% of the ice in 2010 and 2011, respectively. Overall, the results indicate a regime shift in the characteristics of the ice cover has occurred in the region over recent decades, with substantive implications for thermodynamic forcing, light availability in the upper ocean, and biological and biogeochemical processes in the ice and water column beneath. The results presented have applications for the interpretation of optical and biological measurements in the Chukchi Sea and serve as record of ice conditions for assessing long-term change. Published by Elsevier Ltd.
C1 [Polashenski, Chris; Perovich, Donald K.] ERDC CRREL, Hanover, NH 03755 USA.
[Polashenski, Chris; Perovich, Donald K.] Dartmouth Coll, Hanover, NH 03755 USA.
[Frey, Karen E.; Logvinova, Christie I.; Trusel, Luke D.] Clark Univ, Worcester, MA 01610 USA.
[Cooper, Lee W.; Kelly, Holly P.] Univ Maryland, Ctr Environm Sci, Baltimore, MD USA.
[Dadic, Ruzica] Univ Wellington, Wellington, New Zealand.
[Light, Bonnie; Webster, Melinda] Univ Washington, Seattle, WA 98195 USA.
RP Polashenski, C (reprint author), ERDC CRREL, Hanover, NH 03755 USA.
RI Cooper, Lee/E-5251-2012
OI Cooper, Lee/0000-0001-7734-8388
FU NASA Impacts of Climate change on the EcoSystems and Chemistry of the
Arctic Pacific Environment (ICESCAPE) project; NASA Cryospheric Sciences
Program [NNX10AH71G, NNH10A017IE]; NASA Ocean Biology and
Biogeochemistry Program
FX This research was supported by the NASA Impacts of Climate change on the
EcoSystems and Chemistry of the Arctic Pacific Environment (ICESCAPE)
project with support from the NASA Cryospheric Sciences Program (Grant
#NNX10AH71G to K. Frey, L.W. Cooper, and J.M. Grebmeier and Grant
#NNH10A017IE to D. Perovich and B. Light) and the NASA Ocean Biology and
Biogeochemistry Program. The field component of this research would not
have been possible without the tremendous support from the commanding
officer, marine science technicians, crew, and officers of USCGC Healy
on the HLY1001 and HLY 1101 missions to the Chukchi and Beaufort seas in
June-July 2010 and 2011. We acknowledge and appreciate comments by two
anonymous reviewers which helped to improve this manuscript.
NR 44
TC 3
Z9 3
U1 3
U2 20
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0967-0645
EI 1879-0100
J9 DEEP-SEA RES PT II
JI Deep-Sea Res. Part II-Top. Stud. Oceanogr.
PD AUG
PY 2015
VL 118
SI SI
BP 7
EP 17
DI 10.1016/j.dsr2.2015.04.006
PN A
PG 11
WC Oceanography
SC Oceanography
GA CP9ZV
UT WOS:000360255300002
ER
PT J
AU Liu, RF
Schyman, P
Wallqvist, A
AF Liu, Ruifeng
Schyman, Patric
Wallqvist, Anders
TI Critically Assessing the Predictive Power of QSAR Models for Human Liver
Microsomal Stability
SO JOURNAL OF CHEMICAL INFORMATION AND MODELING
LA English
DT Article
ID RANDOM FOREST; VALIDATION; CANDIDATES; TIME
AB To lower the possibility of late-stage failures in the drug development process, an up-front assessment of absorption, distribution, metabolism, elimination, and toxicity is commonly implemented through a battery of in silico and in vitro assays. As in vitro data is accumulated, in silico quantitative structure-activity relationship (QSAR) models can be trained and used to assess compounds even before they are synthesized. Even though it is generally recognized that QSAR model performance deteriorates over time, rigorous independent studies of model performance deterioration is typically hindered by the lack of publicly available large data sets of structurally diverse compounds. Here, we investigated predictive properties of QSAR models derived from an assembly of publicly available human liver microsomal (HLM) stability data using variable nearest neighbor (v-NN) and random forest (RF) methods. In particular, we evaluated the degree of time-dependent model performance deterioration. Our results show that when evaluated by 10-fold cross-validation with all available HLM data randomly distributed among 10 equal-sized validation groups, we achieved high-quality model performance from both machine-learning methods. However, when we developed FILM models based on when the data appeared and tried to predict data published later, we found that neither method produced predictive models and that their applicability was dramatically reduced. On the other hand, when a small percentage of randomly selected compounds from data published later were included in the training set, performance of both machine-learning methods improved significantly. The implication is that 1) QSAR model quality should be analyzed in a time-dependent manner to assess their true predictive power and 2) it is imperative to retrain models with any up-to-date experimental data to ensure maximum applicability.
C1 [Liu, Ruifeng; Schyman, Patric; Wallqvist, Anders] US Army Med Res & Mat Command, Telemed & Adv Technol Res Ctr, DoD Biotechnol High Performance Comp Software App, MCMR TT, Ft Detrick, MD 21702 USA.
RP Liu, RF (reprint author), US Army Med Res & Mat Command, Telemed & Adv Technol Res Ctr, DoD Biotechnol High Performance Comp Software App, MCMR TT, 504 Scott St, Ft Detrick, MD 21702 USA.
EM RLiu@bhsai.org; Sven.A.Wallqvist.civ@mail.mil
RI Schyman, Patric/F-1810-2011;
OI wallqvist, anders/0000-0002-9775-7469
FU U.S. Army Medical Research and Materiel Command (Fort Detrick, MD) as
part of U.S. Army's Network Science Initiative; Defense Threat Reduction
Agency grant [CBCall14-CBS-05-2-0007]
FX The authors were supported by the U.S. Army Medical Research and
Materiel Command (Fort Detrick, MD), as part of the U.S. Army's Network
Science Initiative, and the Defense Threat Reduction Agency grant
CBCall14-CBS-05-2-0007. The opinions and assertions contained herein are
the private views of the authors and are not to be construed as official
or as reflecting the views of the U.S. Army or of the U.S. Department
NR 22
TC 3
Z9 3
U1 2
U2 11
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1549-9596
EI 1549-960X
J9 J CHEM INF MODEL
JI J. Chem Inf. Model.
PD AUG
PY 2015
VL 55
IS 8
BP 1566
EP 1575
DI 10.1021/acs.jcim.5b00255
PG 10
WC Chemistry, Medicinal; Chemistry, Multidisciplinary; Computer Science,
Information Systems; Computer Science, Interdisciplinary Applications
SC Pharmacology & Pharmacy; Chemistry; Computer Science
GA CQ0XV
UT WOS:000360322800008
PM 26170251
ER
PT J
AU Pal, S
Richardson, JH
Murphy, JR
Krairojananan, P
Kongtak, P
Jaichapor, B
Kankaew, P
Ekanayake, S
Davis, TJ
Maserang, DL
Teng, DHF
Crisp, RJ
Wu, SJL
Coleman, RE
McAvin, JC
Swaby, JA
AF Pal, Subhamoy
Richardson, Jason H.
Murphy, Jittawadee R.
Krairojananan, Panadda
Kongtak, Patcharee
Jaichapor, Boonsong
Kankaew, Prasan
Ekanayake, Sajeewane
Davis, Timothy J.
Maserang, David L.
Teng, David H. F.
Crisp, Robert J.
Wu, Shuenn-Jue L.
Coleman, Russell E.
McAvin, James C.
Swaby, James A.
TI Detection of Dengue Virus in Mosquito Extracts and Human Clinical
Samples Using a Field Expedient Molecular Platform
SO MILITARY MEDICINE
LA English
DT Article
ID POLYMERASE CHAIN-REACTION; RAPID IDENTIFICATION; RNA CONTROLS; ARMORED
RNA; IMMUNOFLUORESCENCE; ASSAYS; FEVER; HAITI; IRAQ; DNA
AB Dengue fever occurs in localized outbreaks and can significantly erode troop strength and mission readiness. Timely identification of dengue virus (DENV) provides for rapid and appropriate patient management decisions, such as medical evacuation and supportive therapies, as well as help to promote Force Health Protection through vector control and personal protective measures. The "Ruggedized" Advanced Pathogen Identification Device is a field-friendly PCR (Polymerase Chain Reaction) platform that can be used to facilitate early identification of DENV. We developed a dry-format PCR assay on this platform. The assay demonstrated 100% analytical specificity for detecting dengue using a cross-reactivity panel. We used a panel of 102 acute, DENV isolation positive serum samples and 25 DENV negative samples; the assay demonstrated a clinical sensitivity of 97.1% (95% C.I. 91.6-99.4%) and specificity of 96.0% (95% C.I. 79.7-99.9%) in identifying patients with dengue infection. We also used the assay to test mosquito homogenates from 28 adult female Aedes aegypti. A single DENV infected mosquito was identified using the PCR assay and confirmed using immunofluorescence as a reference method. Much of the testing was performed under austere field conditions. Together, our results demonstrate the utility of this assay for detecting DENV in vector and human samples in field environments.
C1 [Pal, Subhamoy; Ekanayake, Sajeewane; Wu, Shuenn-Jue L.] Naval Med Res Ctr, Viral & Rickettsial Dis Dept, Silver Spring, MD 20910 USA.
[Richardson, Jason H.; Murphy, Jittawadee R.; Krairojananan, Panadda; Kongtak, Patcharee; Jaichapor, Boonsong; Kankaew, Prasan; McAvin, James C.] Armed Forces Res Inst Med Sci, Dept Entomol, Bangkok 10400, Thailand.
[Davis, Timothy J.] USAF Sch Aerosp Med, Kadena AB, Okinawa 96368, Japan.
[Maserang, David L.] Adv Technol Ctr, San Antonio, TX 78235 USA.
[Teng, David H. F.; Crisp, Robert J.] BioFire Diagnost LLC, Salt Lake City, UT 84108 USA.
[Coleman, Russell E.] Chem & Biol Def, Joint Programs Execut Off, Ft Detrick, MD 21702 USA.
RP Pal, S (reprint author), Naval Med Res Ctr, Viral & Rickettsial Dis Dept, 503 Robert Grant Ave, Silver Spring, MD 20910 USA.
RI Pal, Subhamoy/A-9526-2015
OI Pal, Subhamoy/0000-0003-0133-8444
FU Office of the Air Force Surgeon General, Directorate of Modernization,
Falls Church, Virginia; Military Infectious Diseases Research Program,
USAMRC, Fort Detrick, Maryland [6000.RAD1.L.A0311]
FX This work was funded in part by the Office of the Air Force Surgeon
General, Directorate of Modernization, Falls Church, Virginia, and
Military Infectious Diseases Research Program work unit number
6000.RAD1.L.A0311, USAMRC, Fort Detrick, Maryland.
NR 30
TC 0
Z9 0
U1 2
U2 7
PU ASSOC MILITARY SURG US
PI BETHESDA
PA 9320 OLD GEORGETOWN RD, BETHESDA, MD 20814 USA
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD AUG
PY 2015
VL 180
IS 9
BP 937
EP 942
DI 10.7205/MILMED-D-14-00428
PG 6
WC Medicine, General & Internal
SC General & Internal Medicine
GA CQ3TL
UT WOS:000360525600004
PM 26327544
ER
PT J
AU Becker, RA
Ankley, GT
Edwards, SW
Kennedy, SW
Linkov, I
Meek, B
Sachana, M
Segner, H
Van der Burg, B
Villeneuve, DL
Watanabe, H
Barton-Maclaren, TS
AF Becker, Richard A.
Ankley, Gerald T.
Edwards, Stephen W.
Kennedy, Sean W.
Linkov, Igor
Meek, Bette
Sachana, Magdalini
Segner, Helmut
Van der Burg, Bart
Villeneuve, Daniel L.
Watanabe, Haruna
Barton-Maclaren, Tara S.
TI Increasing Scientific Confidence in Adverse Outcome Pathways:
Application of Tailored Bradford-Hill Considerations for Evaluating
Weight of Evidence
SO REGULATORY TOXICOLOGY AND PHARMACOLOGY
LA English
DT Article
DE Adverse outcome pathway; Weight of evidence; Mode of action;
Bradford-Hill considerations
ID ARYL-HYDROCARBON RECEPTOR; INDUCED DELAYED NEUROTOXICITY; OXIDATIVE
STRESS-RESPONSE; HEXAVALENT CHROMIUM; ESTROGEN-RECEPTOR;
GENE-EXPRESSION; REACTIVE OXYGEN; DRINKING-WATER; DAPHNIA-MAGNA; MOUSE
DUODENUM
AB Systematic consideration of scientific support is a critical element in developing and, ultimately, using adverse outcome pathways (AOPs) for various regulatory applications. Though weight of evidence (WoE) analysis has been proposed as a basis for assessment of the maturity and level of confidence in an AOP, methodologies and tools are still being formalized. The Organization for Economic Co-operation and Development (OECD) Users' Handbook Supplement to the Guidance Document for Developing and Assessing AOPs (OECD 2014a; hereafter referred to as the OECD AOP Handbook) provides tailored Bradford-Hill (BH) considerations for systematic assessment of confidence in a given AOP. These considerations include (1) biological plausibility and (2) empirical support (dose-response, temporality, and incidence) for Key Event Relationships (KERs), and (3) essentiality of key events (KEs). Here, we test the application of these tailored BH considerations and the guidance outlined in the OECD AOP Handbook using a number of case examples to increase experience in more transparently documenting rationales for assigned levels of confidence to KEs and KERs, and to promote consistency in evaluation within and across AOPs. The major lessons learned from experience are documented, and taken together with the case examples, should contribute to better common understanding of the nature and form of documentation required to increase confidence in the application of AOPs for specific uses. Based on the tailored BH considerations and defining questions, a prototype quantitative model for assessing the WoE of an AOP using tools of multi-criteria decision analysis (MCDA) is described. The applicability of the approach is also demonstrated using the case example aromatase inhibition leading to reproductive dysfunction in fish. Following the acquisition of additional experience in the development and assessment of AOPs, further refinement of parameterization of the model through expert elicitation is recommended. Overall, the application of quantitative WoE approaches hold promise to enhance the rigor, transparency and reproducibility for AOP WoE determinations and may play an important role in delineating areas where research would have the greatest impact on improving the overall confidence in the AOP. (C) 2015 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
C1 [Becker, Richard A.] Amer Chem Council, Washington, DC 20002 USA.
[Ankley, Gerald T.; Villeneuve, Daniel L.] US EPA, Off Res & Dev, Midcontinent Ecol Div, Duluth, MN USA.
[Edwards, Stephen W.] US EPA, Off Res & Dev, Integrated Syst Toxicol Div, Res Triangle Pk, NC 27711 USA.
[Kennedy, Sean W.] Environm Canada, Natl Wildlife Res Ctr, Ottawa, ON K1A 0H3, Canada.
[Linkov, Igor] US Army Corps Engineers, Engineer Res & Dev Ctr, Environm Lab, Concord, MA USA.
[Meek, Bette] Univ Ottawa, Ottawa, ON, Canada.
[Sachana, Magdalini] European Commiss, Joint Res Ctr, I-21027 Ispra, Italy.
[Segner, Helmut] Univ Bern, Ctr Fish & Wildlife Hlth, Bern, Switzerland.
[Van der Burg, Bart] BioDetect Syst BV, Amsterdam, Netherlands.
[Watanabe, Haruna] Natl Inst Environm Studies, Ctr Environm Risk Res, Tsukuba, Ibaraki, Japan.
[Barton-Maclaren, Tara S.] Hlth Canada, Existing Subst Risk Assessment Bur, Ottawa, ON K1A 0L2, Canada.
RP Becker, RA (reprint author), Amer Chem Council, 700 2nd St NE, Washington, DC 20002 USA.
EM ricic_becker@americanchemistry.com
FU Research Council of Norway [221455]
FX The content of this paper is the result of an international expert
workshop on Advancing Adverse Outcome Pathways (AOPs) for Integrated
Toxicology and Regulatory Applications held March 2-7, 2014 in Somma
Lombardo, Italy. Support for the workshop was provided by the American
Chemistry Council, BioDetection Systems, European Centre for
Ecotoxicology and Toxicology of Chemicals, Environment Canada, European
Commission Directorate General Joint Research Center, Human Toxicology
Project Consortium, International Life Sciences Institute - Health and
Environmental Science Institute, The Research Council of Norway (Grant
no. 221455), Society for Environmental Toxicology and Chemistry, US Army
Engineer Research and Development Center, and the US Environmental
Protection Agency. The authors acknowledge the workshop organizing
committee (Rick Becker, Natalia Garcia-Reyero, Ksenia Groh, Marlies
Halder, Sean Kennedy, Teresa Lettieri, Edward Perkins, Knut Erik
Tollefsen, Bart van der Burg, Dan Villeneuve, and Maurice Whelan), and
all workshop participants for both plenary and informal discussions that
influenced the content presented here. The views expressed are those of
the authors, and do not necessarily represent the views of the
organizations the authors are affiliated with or the sponsors. Mention
of trade names or commercial products does not constitute endorsement or
recommendation for use.
NR 82
TC 20
Z9 21
U1 2
U2 22
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0273-2300
EI 1096-0295
J9 REGUL TOXICOL PHARM
JI Regul. Toxicol. Pharmacol.
PD AUG
PY 2015
VL 72
IS 3
BP 514
EP 537
DI 10.1016/j.yrtph.2015.04.004
PG 24
WC Medicine, Legal; Pharmacology & Pharmacy; Toxicology
SC Legal Medicine; Pharmacology & Pharmacy; Toxicology
GA CP9ZZ
UT WOS:000360255700010
PM 25863193
ER
PT J
AU Cote, CK
Welkos, SL
AF Cote, Christopher K.
Welkos, Susan L.
TI Anthrax Toxins in Context of Bacillus anthracis Spores and Spore
Germination
SO TOXINS
LA English
DT Review
ID CAPILLARY MORPHOGENESIS PROTEIN-2; LETHAL FACTOR CLEAVES;
ETOSHA-NATIONAL-PARK; PROTECTIVE ANTIGEN; IN-VIVO; INHALATIONAL ANTHRAX;
DENDRITIC CELLS; GASTROINTESTINAL ANTHRAX; MACROPHAGE APOPTOSIS;
INJECTIONAL ANTHRAX
AB The interaction of anthrax toxin or toxin components with B. anthracis spores has been demonstrated. Germinating spores can produce significant amounts of toxin components very soon after the initiation of germination. In this review, we will summarize the work performed that has led to our understanding of toxin and spore interactions and discuss the complexities associated with these interactions.
C1 [Cote, Christopher K.; Welkos, Susan L.] US Army, Med Res Inst Infect Dis, Bacteriol Div, Ft Detrick, MD 21702 USA.
RP Cote, CK (reprint author), US Army, Med Res Inst Infect Dis, Bacteriol Div, 1425 Porter St, Ft Detrick, MD 21702 USA.
EM christopher.k.cote.civ@mail.mil; susan.l.welkos.civ@mail.mil
NR 105
TC 1
Z9 1
U1 2
U2 13
PU MDPI AG
PI BASEL
PA POSTFACH, CH-4005 BASEL, SWITZERLAND
SN 2072-6651
J9 TOXINS
JI Toxins
PD AUG
PY 2015
VL 7
IS 8
BP 3167
EP 3178
DI 10.3390/toxins7083167
PG 12
WC Toxicology
SC Toxicology
GA CP9GU
UT WOS:000360202700026
PM 26287244
ER
PT J
AU Thompson, CM
Suh, M
Proctor, DM
Haws, LC
Hixon, JG
Wolf, JC
Young, RR
Elbekai, RH
O'Brien, TJ
Parsons, BL
Seiter, JM
Chappell, MA
Harris, MA
AF Thompson, C. M.
Suh, M.
Proctor, D. M.
Haws, L. C.
Hixon, J. G.
Wolf, J. C.
Young, R. R.
Elbekai, R. H.
O'Brien, T. J.
Parsons, B. L.
Seiter, J. M.
Chappell, M. A.
Harris, M. A.
TI Follow-Up Assessment of In Vivo Genotoxicity in Target Organs of
Relevant Species Identified from a Two-Year Cancer Bioassay: Case Study
with Hexavalent Chromium.
SO ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
LA English
DT Meeting Abstract
C1 [Thompson, C. M.; Harris, M. A.] ToxStrategies Inc, Katy, TX USA.
[Suh, M.; Proctor, D. M.] ToxStrategies Inc, Mission Viejo, CA USA.
[Haws, L. C.; Hixon, J. G.] ToxStrategies Inc, Austin, TX USA.
[Wolf, J. C.] Expt Pathol Labs, Sterling, VA USA.
[Young, R. R.; Elbekai, R. H.] BioReliance, Rockville, MD USA.
[O'Brien, T. J.] George Washington Univ, Med Ctr, Washington, DC 20037 USA.
[Parsons, B. L.] US FDA, Natl Ctr Toxicol Res, Jefferson, AR 72079 USA.
[Seiter, J. M.; Chappell, M. A.] US Army Engineer Res & Dev Ctr, Vicksburg, MS USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0893-6692
EI 1098-2280
J9 ENVIRON MOL MUTAGEN
JI Environ. Mol. Mutagen.
PD AUG
PY 2015
VL 56
SU 1
MA 12
BP S52
EP S52
PG 1
WC Environmental Sciences; Genetics & Heredity; Toxicology
SC Environmental Sciences & Ecology; Genetics & Heredity; Toxicology
GA CP9PJ
UT WOS:000360226400089
ER
PT J
AU Gao, JH
Zhao, Q
Swami, A
AF Gao, Jianhang
Zhao, Qing
Swami, Ananthram
TI The Thinnest Path Problem
SO IEEE-ACM TRANSACTIONS ON NETWORKING
LA English
DT Article
DE Approximation algorithms; approximation ratio; hypergraph; NP-complete;
secure communication; thinnest path
ID DIRECTED HYPERGRAPHS
AB We formulate and study the thinnest path problem for secure communication in wireless ad hoc networks. The objective is to find a path from a source to its destination that results in the minimum number of nodes overhearing the message by a judicious choice of relaying nodes and their corresponding transmission powers. We adopt a directed hypergraph model of the problem and establish the NP-completeness of the problem in 2-D networks. We then develop two polynomial-time approximation algorithms that offer root n/2 n/2 root n-1 and approximation ratios for general directed hypergraphs (which can model nonisotropic signal propagation in space) and constant approximation ratios for ring hypergraphs (which result from isotropic signal propagation). We also consider the thinnest path problem in 1-D networks and 1-D networks embedded in a 2-D field of eavesdroppers with arbitrary unknown locations (the so-called 1.5-D networks). We propose a linear-complexity algorithm based on nested backward induction that obtains the optimal solution for both 1-D and 1.5-D networks. This algorithm does not require the knowledge of eavesdropper locations and achieves the best performance offered by any algorithm that assumes complete location information of the eavesdroppers.
C1 [Gao, Jianhang; Zhao, Qing] Univ Calif Davis, Davis, CA 95616 USA.
[Swami, Ananthram] Army Res Lab, Adelphi, MD 20783 USA.
RP Gao, JH (reprint author), Univ Calif Davis, Davis, CA 95616 USA.
EM jhgao@ucdavis.edu; qzhao@ucdavis.edu; a.swami@ieee.org
FU Army Research Laboratory Network Science CTA [W911NF-09-2-0053]
FX Manuscript received October 22, 2013; revised February 28, 2014;
accepted April 12, 2014; approved by IEEE/ACM TRANSACTIONS ON NETWORKING
Editor G. Xue. Date of publication June 03, 2014; date of current
version August 14, 2015. This work was supported by the Army Research
Laboratory Network Science CTA under Cooperative Agreement
W911NF-09-2-0053.
NR 15
TC 0
Z9 0
U1 0
U2 2
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 1063-6692
EI 1558-2566
J9 IEEE ACM T NETWORK
JI IEEE-ACM Trans. Netw.
PD AUG
PY 2015
VL 23
IS 4
BP 1176
EP 1189
DI 10.1109/TNET.2014.2321159
PG 14
WC Computer Science, Hardware & Architecture; Computer Science, Theory &
Methods; Engineering, Electrical & Electronic; Telecommunications
SC Computer Science; Engineering; Telecommunications
GA CP7KX
UT WOS:000360067600012
ER
PT J
AU Decker, AW
McHale, SR
Shannon, MP
Clinton, JA
McClory, JW
AF Decker, Andrew W.
McHale, Stephen R.
Shannon, Michael P.
Clinton, Justin A.
McClory, John W.
TI Novel Bonner Sphere Spectrometer Response Functions Using MCNP6
SO IEEE TRANSACTIONS ON NUCLEAR SCIENCE
LA English
DT Article
DE Monte Carlo method; neutron radiation effects; radiation dosage;
scintillation counters
AB Bonner Sphere Spectrometer response functions were computed using MCNP6 and compared to response functions calculated by Mares and Schraube (1994) using MCNP4. The simulated environment exposed a LiI(Eu) scintillator crystal to neutrons of discrete energy levels from thermal through 25 MeV, with energy resolution identical to that documented by Mares and Schraube. The shapes of the response functions were found to be in excellent agreement with previous data, but the MCNP6-calculated functions differed consistently from the Mares and Schraube data by a factor of two, which is possibly due to ambiguity within their published methodology. Regardless, a comparison of the response functions calculated from MCNP6 and MCNP4 were assessed as > 99% significant using a chi-squared test with 25 degrees of freedom.
C1 [Decker, Andrew W.; Shannon, Michael P.] US Mil Acad, NSERC, West Point, NY 10996 USA.
[McHale, Stephen R.; Clinton, Justin A.; McClory, John W.] Air Force Inst Technol, Wright Patterson AFB, OH 45433 USA.
RP Decker, AW (reprint author), US Mil Acad, NSERC, West Point, NY 10996 USA.
EM andrew.decker@dtra.mil; stephen.mchale@afit.edu;
michael.shannon@dtra.mil; justin.clinton@afit.edu; john.mcclory@afit.edu
FU Nuclear Technologies Department of the Defense Threat Reduction Agency
FX The authors would like to thank the Nuclear Technologies Department of
the Defense Threat Reduction Agency for their support of this research.
NR 12
TC 0
Z9 0
U1 1
U2 5
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 0018-9499
EI 1558-1578
J9 IEEE T NUCL SCI
JI IEEE Trans. Nucl. Sci.
PD AUG
PY 2015
VL 62
IS 4
BP 1689
EP 1694
DI 10.1109/TNS.2015.2416652
PN 1
PG 6
WC Engineering, Electrical & Electronic; Nuclear Science & Technology
SC Engineering; Nuclear Science & Technology
GA CP6RR
UT WOS:000360016200025
ER
PT J
AU Cao, CJ
O'Neill, AJ
Crouse, LC
AF Cao, C. J.
O'Neill, A. J.
Crouse, L. C.
TI CELLUAR AND MOLECULAR TOXICOLOGY
SO IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL
LA English
DT Meeting Abstract
C1 [Cao, C. J.; O'Neill, A. J.; Crouse, L. C.] US Army Publ Hlth Command, Inst Publ Hlth, Toxicol Portfolio, Aberdeen Proving Ground, MD 21010 USA.
EM cheng.j.cao.civ@mail.mil
NR 0
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1071-2690
EI 1543-706X
J9 IN VITRO CELL DEV-AN
JI In Vitro Cell. Dev. Biol.-Anim.
PD AUG
PY 2015
VL 51
IS 7
MA A-3003
BP 761
EP 762
PG 2
WC Cell Biology; Developmental Biology
SC Cell Biology; Developmental Biology
GA CP5NK
UT WOS:000359928900021
ER
PT J
AU Zourdos, MC
Henning, PC
Jo, E
Khamoui, AV
Lee, SR
Park, YM
Naimo, M
Panton, LB
Nosaka, K
Kim, JS
AF Zourdos, Michael C.
Henning, Paul C.
Jo, Edward
Khamoui, Andy V.
Lee, Sang-Rok
Park, Young-Min
Naimo, Marshall
Panton, Lynn B.
Nosaka, Kazunori
Kim, Jeong-Su
TI REPEATED BOUT EFFECT IN MUSCLE-SPECIFIC EXERCISE VARIATIONS
SO JOURNAL OF STRENGTH AND CONDITIONING RESEARCH
LA English
DT Article
DE muscle damage; resistance training; eccentric exercise; incline curls;
preacher curls
ID FORCE ECCENTRIC EXERCISE; ELBOW FLEXORS; DAMAGE; CONTRACTIONS;
ADAPTATION; LONG; MECHANISMS; INTENSITY; MAGNITUDE; NUMBER
AB Zourdos, MC, Henning, PC, Jo, E, Khamoui, AV, Lee, S-R, Park, Y-M, Naimo, M, Panton, LB, Nosaka, K, and Kim, J-S. Repeated bout effect in muscle-specific exercise variations. J Strength Cond Res 29(8): 2270-2276, 2015A single bout of unaccustomed exercise confers protective effect against muscle damage from a subsequent bout of similar activity, that is, repeated bout effect (RBE). It remains unknown whether varying muscle-specific exercise between sessions alters the magnitude of the RBE. This study examined the effects of muscle-specific exercise variation between consecutive sessions on the RBE. Twenty untrained males (21 +/- 2 years) were assigned to one of 2 groups (n = 10 per group): (a) 2 sessions of incline curls, Fixed Exercise or (b) 1 session of incline curls followed by 1 session of preacher curls, Varied Exercise, with 7 days between sessions. Subjects performed 5 sets of 6 repetitions at approximate to 50% of maximal isometric elbow flexor strength during each session. Changes in maximal voluntary isometric and isokinetic torque, range of motion, muscle soreness, and serum creatine kinase were measured before, immediately after, and 24, 48, 72, and 96 hours after each exercise session, and the changes were compared between bouts and between groups. There were significant time effects (p < 0.05) for isometric maximal voluntary contraction, concentric maximal voluntary contraction, range of motion, and muscle soreness during sessions 1 and 2 with no between-group differences. Both groups demonstrated a significantly faster recovery of range of motion and soreness to baseline levels after session 2 compared with session 1. Overall, our findings suggest that incline curls conferred a protective effect during subsequent preacher curls in a similar way to repeating incline curls; therefore, the RBE was not exercise specific.
C1 [Zourdos, Michael C.] Florida Atlantic Univ, Dept Exercise Sci & Hlth Promot, Boca Raton, FL 33431 USA.
[Henning, Paul C.] US Army, Environm Med Res Inst, Mil Performance Div, Natick, MA 01760 USA.
[Jo, Edward] Calif State Polytech Univ Pomona, Dept Kinesiol & Hlth Promot, Pomona, CA 91768 USA.
[Khamoui, Andy V.; Naimo, Marshall; Panton, Lynn B.; Kim, Jeong-Su] Florida State Univ, Dept Nutr Food & Exercise Sci, Tallahassee, FL 32306 USA.
[Lee, Sang-Rok] Univ Memphis, Dept Hlth & Sport Sci, Memphis, TN 38152 USA.
[Park, Young-Min] Univ Missouri, Dept Nutr & Exercise Physiol, Columbia, MO USA.
[Nosaka, Kazunori] Edith Cowan Univ, Sch Exercise & Hlth Sci, Ctr Exercise & Sports Sci Res, Joondalup, WA, Australia.
RP Kim, JS (reprint author), Florida State Univ, Dept Nutr Food & Exercise Sci, Tallahassee, FL 32306 USA.
EM jkim6@fsu.edu
RI Nosaka, Kazunori/H-4412-2011
OI Nosaka, Kazunori/0000-0001-7373-4994
NR 27
TC 1
Z9 1
U1 1
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1064-8011
EI 1533-4287
J9 J STRENGTH COND RES
JI J. Strength Cond. Res.
PD AUG
PY 2015
VL 29
IS 8
BP 2270
EP 2276
DI 10.1519/JSC.0000000000000856
PG 7
WC Sport Sciences
SC Sport Sciences
GA CP3VE
UT WOS:000359809900024
PM 25647658
ER
PT J
AU Thompson, CM
Wolf, JC
Elbekai, RH
Paranjpe, MG
Seiter, JM
Chappell, MA
Tappero, RV
Suh, M
Proctor, DM
Bichteler, A
Haws, LC
Harris, MA
AF Thompson, Chad M.
Wolf, Jeffrey C.
Elbekai, Reem H.
Paranjpe, Madhav G.
Seiter, Jennifer M.
Chappell, Mark A.
Tappero, Ryan V.
Suh, Mina
Proctor, Deborah M.
Bichteler, Anne
Haws, Laurie C.
Harris, Mark A.
TI Duodenal crypt health following exposure to Cr(VI): Micronucleus
scoring, gamma-H2AX immunostaining, and synchrotron X-ray fluorescence
microscopy
SO MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
LA English
DT Article
DE Hexavalent chromium; Cr(VI); Synchrotron; Duodenum; Carcinogenesis; Mode
of action; gamma-H2AX
ID HEXAVALENT CHROMIUM; STEM-CELLS; DRINKING-WATER; MOUSE DUODENUM; HISTONE
H2AX; B6C3F1 MICE; CANCER; MODE; PHOSPHORYLATION; HUMANS
AB Lifetime exposure to high concentrations of hexavalent chromium [Cr(VI)] in drinking water results in intestinal damage and an increase in duodenal tumors in B6C3F1 mice. To assess whether these tumors could be the result of a direct mutagenic or genotoxic mode of action, we conducted a GLP-compliant 7-day drinking water study to assess crypt health along the entire length of the duodenum. Mice were exposed to water (vehicle control), 1.4, 21, or 180 ppm Cr(VI) via drinking water for 7 consecutive days. Crypt enterocytes in Swiss roll sections were scored as normal, mitotic, apoptotic, karyorrhectic, or as having micronuclei. A single oral gavage of 50 mg/kg cyclophosphamide served as a positive control for micronucleus induction. Exposure to 21 and 180 ppm Cr(VI) significantly increased the number of crypt enterocytes. Micronuclei and gamma-H2AX immunostaining were not elevated in the crypts of Cr(VI)treated mice. In contrast, treatment with cyclophosphamide significantly increased numbers of crypt micronuclei and qualitatively increased gamma-H2AX immunostaining. Synchrotron-based X-ray fluorescence (XRF) microscopy revealed the presence of strong Cr fluorescence in duodenal villi, but negligible Cr fluorescence in the crypt compartment. Together, these data indicate that Cr(VI) does not adversely effect the crypt compartment where intestinal stem cells reside, and provide additional evidence that the mode of action for Cr(VI)-induced intestinal cancer in B6C3F1 mice involves chronic villous wounding resulting in compensatory crypt enterocyte hyperplasia. (C) 2015 The Authors. Published by Elsevier B.V.
C1 [Thompson, Chad M.; Harris, Mark A.] ToxStrategies Inc, Katy, TX 77494 USA.
[Wolf, Jeffrey C.] Expt Pathol Labs, Sterling, VA 20166 USA.
[Elbekai, Reem H.; Paranjpe, Madhav G.] BioReliance, Rockville, MD USA.
[Seiter, Jennifer M.; Chappell, Mark A.] US Army Engineer Res & Dev Ctr, Vicksburg, MS 39180 USA.
[Tappero, Ryan V.] Brookhaven Natl Lab, Photon Sci Dept, Upton, NY 11973 USA.
[Suh, Mina; Proctor, Deborah M.] ToxStrategies Inc, Mission Viejo, CA 92692 USA.
[Bichteler, Anne; Haws, Laurie C.] ToxStrategies Inc, Austin, TX 78731 USA.
RP Thompson, CM (reprint author), ToxStrategies Inc, 23123 Cinco Ranch Blvd,Suite 220, Katy, TX 77494 USA.
EM cthompson@toxstrategies.com; jWolf@epl-inc.com;
reem.elbekai@bioreliance.com; madhav.paranjpe@bioreliance.com;
jennifer.M.Seiter@erdc.dren.mil; Mark.A.Chappell@usace.army.mil;
rtappero@bnl.gov; msuh@toxstrategies.com; dproctor@toxstrategies.com;
abichteler@toxstrategies.com; lhaws@toxstrategies.com;
mharris@toxstrategies.com
FU Cr(VI) Panel of the American Chemistry Council; U.S. Department of
Energy (DOE) - Geosciences [DE-FG02-92ER14244]; DOE, Office of Science,
Office of Basic Energy Sciences [DE-AC02-98CH10886]
FX This work was supported by the Cr(VI) Panel of the American Chemistry
Council. Beamline X27A is supported in part by the U.S. Department of
Energy (DOE) - Geosciences (DE-FG02-92ER14244 to The University of
Chicago - CARS). Use of the NSLS was supported by the DOE, Office of
Science, Office of Basic Energy Sciences, under Contract No.
DE-AC02-98CH10886.
NR 44
TC 5
Z9 5
U1 1
U2 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1383-5718
EI 1879-3592
J9 MUTAT RES-GEN TOX EN
JI Mutat. Res. Genet. Toxicol. Environ. Mutagen.
PD AUG
PY 2015
VL 789
BP 61
EP 66
DI 10.1016/j.mrgentox.2015.05.004
PG 6
WC Biotechnology & Applied Microbiology; Genetics & Heredity; Toxicology
SC Biotechnology & Applied Microbiology; Genetics & Heredity; Toxicology
GA CP5XV
UT WOS:000359959600007
PM 26232259
ER
PT J
AU Wu, ZZ
Ji, SP
Zheng, JX
Hu, ZX
Xiao, S
Wei, Y
Zhuo, ZQ
Lin, Y
Yang, WL
Xu, K
Amine, K
Pan, F
AF Wu, Zhongzhen
Ji, Shunping
Zheng, Jiaxin
Hu, Zongxiang
Xiao, Shu
Wei, Yi
Zhuo, Zengqing
Lin, Yuan
Yang, Wanli
Xu, Kang
Amine, Khalil
Pan, Feng
TI Prelithiation Activates Li(Ni0.5Mn0.3Co0.2)O-2 for High Capacity and
Excellent Cycling Stability
SO NANO LETTERS
LA English
DT Article
DE prelithiation; two-layer Li; Li(Ni0.5Mn0.3Co0.2)O-2; carbint nanotube
(CNT); solid electrolyte interface (SEI)
ID LITHIUM-ION BATTERIES; ATOMIC LAYER DEPOSITION; CATHODE MATERIALS;
CARBON; ELECTRODES; NI; HYDROGENATION; FADE; CO
AB Transition metal oxide materials Li(NiMnyCoz)O-2 (NMC) based on layered structures are expected to replace LiFePO4 in automotive Li-ion batteries because of their higher specific capacity and operating potential. However, the actual usable capacity is much lower than the promised theoretical value [Uchaker, E.; Cao, G. Nano Today 2014 9, 499-524; Tarascon, J.-M.; Armand, M. Nature 2001 414, 359-367], in addition to the often poor cycling performance and the first-cycle Coulombic efficiency, for which Mn(II)-dissolution, its immobilization in solid electrolyte interface (SEI), oxidation of electrolytes by Ni, and other parasitic process thereat have been held responsible [Zhan, C., et al. Nat. Commun. 2013 4, 2437; Wang, L,et al. J. Solid State Electrochem. 2009 13, 1157-1164; Lin, F., et al. Nat. Commun. 2014.5, 4529]. Previously, we reported a composite Li(Ni0.5Mn0.3Co0.2)O-2 (NMC532) depolarized by the embedded carbon nanotube (CNT) and achieved capacity close to the theoretical limit [Wu, Z., et al. Nano. Lett. 2014 14, 4700-4706]; unfortunately, this high capacity failed to be maintained in long-term cycling due to the degrading contacts between the active ingredient and CNT network. On the basis of that NMC532/ CNT composite, the present work proposes a unique "prelithiation process", which brought the cathode to low potentials before regular cycling and led to an intetphase that is normally formed only on anode surfaces. The complete coverage of cathode surface by this, similar to 40 nm thick interphase effectively prevented Mn(II) dissolution and minimized the side reactions of Ni, Co, and Mn at the NMC interface during the subsequent cycling process. More importantly, such a "prelithiation" process activated a structure containing two Li layers near the surface of NMC532 particles, as verified by XRD and first principle calculation. Hence, a new cathode material of both high capacity with depolarized structure and excellent cycling performance was generated. This new structure can be incorporated in essentially all the NMC-based layered cathode materials, providing us with an effective tool to tailor-design future new cathode materials for lithium batteries.
C1 [Wu, Zhongzhen; Ji, Shunping; Zheng, Jiaxin; Hu, Zongxiang; Xiao, Shu; Wei, Yi; Zhuo, Zengqing; Lin, Yuan; Amine, Khalil; Pan, Feng] Peking Univ, Shenzhen Grad Sch, Sch Adv Mat, Shenzhen 518055, Peoples R China.
[Zhuo, Zengqing; Yang, Wanli] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Adv Light Source, Berkeley, CA 94720 USA.
[Xu, Kang] US Army Res Lab, Adelphi, MD 20783 USA.
[Amine, Khalil] Argonne Natl Lab, Chem Sci & Engn Div, Electrochem Technol Program, Argonne, IL 60439 USA.
RP Pan, F (reprint author), Peking Univ, Shenzhen Grad Sch, Sch Adv Mat, Shenzhen 518055, Peoples R China.
EM panfeng@pkusz.edu.cn
RI Yang, Wanli/D-7183-2011; lin, yuan/G-9390-2013
OI Yang, Wanli/0000-0003-0666-8063; lin, yuan/0000-0003-3410-3588
FU National Science Foundation of China [51301004]; Shenzhen Science and
Technology Research Grant [JCYJ20140903102215536,
CXZZ20120829172325895]; Guangdong - Hong Kong Technology Cooperation
Funding [SGLH20120928095706623, GHP/015/12SZ]; ShenZhen National
SuperComputing Center
FX This work was financially supported jointly by National Science
Foundation of China (No. 51301004), Shenzhen Science and Technology
Research Grant (No. JCYJ20140903102215536, CXZZ20120829172325895) and
Guangdong - Hong Kong Technology Cooperation Funding
(SGLH20120928095706623 and GHP/015/12SZ). Additionally, we acknowledge
the support of ShenZhen National SuperComputing Center.
NR 26
TC 10
Z9 10
U1 42
U2 242
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1530-6984
EI 1530-6992
J9 NANO LETT
JI Nano Lett.
PD AUG
PY 2015
VL 15
IS 8
BP 5590
EP 5596
DI 10.1021/acs.nanolett.5b02246
PG 7
WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience &
Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied;
Physics, Condensed Matter
SC Chemistry; Science & Technology - Other Topics; Materials Science;
Physics
GA CP1CO
UT WOS:000359613700112
PM 26182195
ER
PT J
AU Scofield, DE
Kardouni, JR
AF Scofield, Dennis E.
Kardouni, Joseph R.
TI The Tactical Athlete: A Product of 21st Century Strength and
Conditioning
SO STRENGTH AND CONDITIONING JOURNAL
LA English
DT Article
DE tactical athlete; military; law enforcement; firefighter; occupational
demands
ID PHYSICAL-FITNESS; TRAINING-PROGRAM; PERFORMANCE; FIREFIGHTERS;
OCCUPATIONS; STANDARDS; ENDURANCE; INJURIES; OUTCOMES; RATES
AB Occupations in law enforcement, the military, or rescue services require personnel to develop general physical preparedness in addition to technical and tactical skills that are crucial in environments involving civil protection, grave physical danger, or rescue situations. The term tactical athlete is commonly used by those in the tactical strength and conditioning community to identify personnel in tactical professionals who require unique physical training strategies aimed at improving occupational performance. The purpose of this article is to promote awareness and provide rationale for use of the term tactical athlete.
C1 [Scofield, Dennis E.; Kardouni, Joseph R.] US Army Res Inst Environm Med, Mil Performance Div, Natick, MA USA.
RP Scofield, DE (reprint author), US Army Res Inst Environm Med, Mil Performance Div, Natick, MA USA.
NR 24
TC 1
Z9 1
U1 1
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1524-1602
EI 1533-4295
J9 STRENGTH COND J
JI Strength Cond. J.
PD AUG
PY 2015
VL 37
IS 4
BP 2
EP 7
DI 10.1519/SSC.0000000000000149
PG 6
WC Sport Sciences
SC Sport Sciences
GA CP3VK
UT WOS:000359810500002
ER
PT J
AU Germane, KL
Servinsky, MD
Gerlach, ES
Sund, CJ
Hurley, MM
AF Germane, Katherine L.
Servinsky, Matthew D.
Gerlach, Elliot S.
Sund, Christian J.
Hurley, Margaret M.
TI Structural analysis of Clostridium acetobutylicum ATCC 824 glycoside
hydrolase from CAZy family GH105
SO ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS
LA English
DT Article
DE Clostridium acetobutylicum; pectin; unsaturated rhamnogalacturonyl
hydrolase; glycoside hydrolase; GH105
ID UNSATURATED GLUCURONYL HYDROLASES; CELL-WALL DEGRADATION; MOLECULAR
REPLACEMENT; BACILLUS-SUBTILIS; CRYSTAL-STRUCTURE; EADOCK DSS; PROTEIN;
FEATURES; DOCKING; SYSTEM
AB Clostridium acetobutylicum ATCC 824 gene CA_C0359 encodes a putative unsaturated rhamnogalacturonyl hydrolase (URH) with distant amino-acid sequence homology to YteR of Bacillus subtilis strain 168. YteR, like other URHs, has core structural homology to unsaturated glucuronyl hydrolases, but hydrolyzes the unsaturated disaccharide derivative of rhamnogalacturonan I. The crystal structure of the recombinant CA_C0359 protein was solved to 1.6 angstrom resolution by molecular replacement using the phase information of the previously reported structure of YteR (PDB entry ) from Bacillus subtilis strain 168. The YteR-like protein is a six--hairpin barrel with two -sheet strands and a small helix overlaying the end of the hairpins next to the active site. The protein has low primary protein sequence identity to YteR but is structurally similar. The two tertiary structures align with a root-mean-square deviation of 1.4 angstrom and contain a highly conserved active pocket. There is a conserved aspartic acid residue in both structures, which has been shown to be important for hydration of the C=C bond during the release of unsaturated galacturonic acid by YteR. A surface electrostatic potential comparison of CA_C0359 and proteins from CAZy families GH88 and GH105 reveals the make-up of the active site to be a combination of the unsaturated rhamnogalacturonyl hydrolase and the unsaturated glucuronyl hydrolase from Bacillus subtilis strain 168. Structural and electrostatic comparisons suggests that the protein may have a slightly different substrate specificity from that of YteR.
C1 [Germane, Katherine L.] Oak Ridge Associated Univ, Belcamp, MD 21017 USA.
[Servinsky, Matthew D.; Sund, Christian J.] US Army Res Lab, RDRL SEE B, Adelphi, MD 20783 USA.
[Gerlach, Elliot S.] Federal Staffing Resources, Annapolis, MD 21401 USA.
[Hurley, Margaret M.] US Army Res Lab, RDRL SEE B, Aberdeen Proving Ground, MD 21005 USA.
RP Germane, KL (reprint author), Oak Ridge Associated Univ, 4692 Millennium Dr,Suite 101, Belcamp, MD 21017 USA.
EM katherine.germane.civ@mail.mil; margaret.m.hurley12.civ@mail.mil
OI germane, katherine/0000-0002-5191-2670
FU NIGMS [U54 GM094662]
FX We acknowledge Vladimir Malashkevich and Jeffrey Bonanno for assistance
with data collection and crystallographic analysis. Jeffrey Bonanno is
supported by NIGMS grant U54 GM094662 to Steven Almo.
NR 51
TC 0
Z9 0
U1 0
U2 7
PU INT UNION CRYSTALLOGRAPHY
PI CHESTER
PA 2 ABBEY SQ, CHESTER, CH1 2HU, ENGLAND
SN 2053-230X
J9 ACTA CRYSTALLOGR F
JI Acta Crystallogr. F-Struct. Biol. Commun.
PD AUG
PY 2015
VL 71
BP 1100
EP 1108
DI 10.1107/S2053230X15012121
PN 8
PG 9
WC Biochemical Research Methods; Biochemistry & Molecular Biology;
Biophysics; Crystallography
SC Biochemistry & Molecular Biology; Biophysics; Crystallography
GA CO7PK
UT WOS:000359352700031
PM 26249707
ER
PT J
AU Buathong, R
Hermann, L
Thaisomboonsuk, B
Rutvisuttinunt, W
Klungthong, C
Chinnawirotpisan, P
Manasatienkij, W
Nisalak, A
Fernandez, S
Yoon, IK
Akrasewi, P
Plipat, T
AF Buathong, Rome
Hermann, Laura
Thaisomboonsuk, Butsaya
Rutvisuttinunt, Wiriya
Klungthong, Chonticha
Chinnawirotpisan, Piyawan
Manasatienkij, Wudtichai
Nisalak, Ananda
Fernandez, Stefan
Yoon, In-Kyu
Akrasewi, Passakorn
Plipat, Tanarak
TI Detection of Zika Virus Infection in Thailand, 2012-2014
SO AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
LA English
DT Article
ID MICRONESIA
AB Zika virus (ZIKV) is an emerging mosquito-borne pathogen with reported cases in Africa, Asia, and large outbreaks in the Pacific. No autochthonous ZIKV infections have been confirmed in Thailand. However, there have been several cases reported in travelers returning from Thailand. Here we report seven cases of acute ZIKV infection in Thai residents across the country confirmed by molecular or serological testing including sequence data. These endemic cases, combined with previous reports in travelers, provide evidence that ZIKV is widespread throughout Thailand.
C1 [Buathong, Rome; Akrasewi, Passakorn; Plipat, Tanarak] Minist Publ Hlth, Dept Dis Control, Bur Epidemiol, Nonthaburi, Thailand.
[Hermann, Laura; Thaisomboonsuk, Butsaya; Rutvisuttinunt, Wiriya; Klungthong, Chonticha; Chinnawirotpisan, Piyawan; Manasatienkij, Wudtichai; Nisalak, Ananda; Fernandez, Stefan; Yoon, In-Kyu] Armed Forces Res Inst Med Sci, Dept Virol, Bangkok 10400, Thailand.
Univ Toronto, Dept Med, Toronto, ON, Canada.
RP Hermann, L (reprint author), Armed Forces Res Inst Med Sci, Dept Virol, 315-6 Rajvithi Rd, Bangkok 10400, Thailand.
EM romebua@health2.moph.go.th; laura.hermann@afrims.org;
butsayat@afrims.org; wiriyar@afrims.org; chontichak@afrims.org;
piyawanc@afrims.org; wudtichaim@afrims.org; anandan.ca@afrims.org;
stefan.fernandez@afrims.org; inkyu.yoon@afrims.org;
pasakorn.sewi@gmail.com; kepidem@gmail.com
FU Canadian Institutes of Health Research
FX Laura Hermann was supported by a Canadian Institutes of Health Research
Fellowship.
NR 20
TC 67
Z9 74
U1 3
U2 43
PU AMER SOC TROP MED & HYGIENE
PI MCLEAN
PA 8000 WESTPARK DR, STE 130, MCLEAN, VA 22101 USA
SN 0002-9637
EI 1476-1645
J9 AM J TROP MED HYG
JI Am. J. Trop. Med. Hyg.
PD AUG
PY 2015
VL 93
IS 2
BP 380
EP 383
DI 10.4269/ajtmh.15-0022
PG 4
WC Public, Environmental & Occupational Health; Tropical Medicine
SC Public, Environmental & Occupational Health; Tropical Medicine
GA CO7GK
UT WOS:000359327400034
PM 26101272
ER
PT J
AU Simon, TE
Johnson, RJ
Naig, AL
Brockmeyer, JR
Prasad, BM
White, PW
AF Simon, Todd E.
Johnson, Rebekah J.
Naig, Anna L.
Brockmeyer, Joel R.
Prasad, Balakrishna M.
White, Paul W.
TI Permacol Interposition Graft as an Alternative to Vein in Contaminated
Wounds Using a Rabbit Model
SO ANNALS OF VASCULAR SURGERY
LA English
DT Article
ID COMPROMISED SURGICAL FIELD; ACELLULAR DERMAL ALLOGRAFT; EXTREMITY
VASCULAR INJURY; VENTRAL HERNIA REPAIR; AUTOGENOUS VEIN; WARTIME REPORT;
INFECTION; DACRON; BIOMATERIAL; MANAGEMENT
AB Background: Vascular injuries are common in trauma and often involve massive soft tissue injury and segmental arterial loss. Current practice uses either autogenous vein or polytetrafluorethylene (PTFE) for interposition grafting in arterial injuries. Decision making between autogenous or synthetic conduit pivots around the physiological state of the trauma patient. Vein is known to increase operative times in an already physiologically depleted patient, whereas synthetic graft can be simply pulled from the shelf. However, when used in contaminated wounds, PTFE is prone to chronic infection and subsequent graft failure. An alternative synthetic conduit resistant to infection would be ideal for such situations. Permacol (Tissue Science Laboratories, Inc, Andover, MA), a biosynthetic material, has demonstrated resistance to bacterial contamination in contaminated hernia repairs. When fashioned into a tubular structure, this material may be useful as an alternative vascular conduit in contaminated trauma wounds.
Methods: New Zealand white rabbits were randomized to one of 4 groups: Permacol graft (P) without bacterial contamination (n = 9), Permacol graft with bacterial contamination (CP; n = 9), autogenous vein graft without bacterial contamination (V; n = 9), or autogenous vein with bacterial contamination (CV; n = 9). All groups then underwent interposition grafting of the right common carotid artery. Grafts were contaminated by applying Staphylococcus aureus (1 x 10(5) colonies/0.1 mL) directly to the exposed surface of the graft on completion of the arterial repair. Each graft was then excised at day 42, and segments were collected for histologic evaluation, bacterial counts, and real-time polymerase chain reaction.
Results: Of the 36 rabbits used in this study, 3 animals in the CV group died within 72 hr of surgery. There was no difference in early mortality between P and V (0% vs. 0%; P = 1.0); however, early mortality was higher in the CV compared with the CP group (33% vs. 0%; P = 0.023). At 42 days, histologic evaluation of graft patency demonstrated no difference between P and V (67% vs. 33%; P = 0.157); however, patency was higher in CP than CV (56% vs. 12%; P - 0.040). In addition, no difference was found between the 2 contaminated groups in regard to the number of bacteria present on each graft material.
Conclusions: Permacol as an interposition graft is a feasible alternative to vein in a contaminated setting and shows resistance to infection in a rabbit model. Future studies are needed to evaluate this material in larger animal models.
C1 [Simon, Todd E.; White, Paul W.] Walter Reed Natl Mil Med Ctr, Div Vasc Surg, Bethesda, MD 20889 USA.
[Johnson, Rebekah J.; Naig, Anna L.; Brockmeyer, Joel R.] Dwight D Eisenhower Army Med Ctr, Div Vasc Surg, Ft Gordon, GA USA.
[Prasad, Balakrishna M.] Dwight D Eisenhower Army Med Ctr, Dept Clin Invest, Ft Gordon, GA USA.
RP Simon, TE (reprint author), Walter Reed Natl Mil Med Ctr, Div Vasc Surg, 8901 Rockville Pike, Bethesda, MD 20889 USA.
EM te.simon@yahoo.com
NR 29
TC 0
Z9 0
U1 0
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0890-5096
EI 1615-5947
J9 ANN VASC SURG
JI Ann. Vasc. Surg.
PD AUG
PY 2015
VL 29
IS 6
BP 1307
EP 1314
DI 10.1016/j.avsg.2015.05.001
PG 8
WC Surgery; Peripheral Vascular Disease
SC Surgery; Cardiovascular System & Cardiology
GA CO7BH
UT WOS:000359312000033
PM 26004967
ER
PT J
AU Wilkison, BD
Sperling, LC
Spillane, AP
Meyerle, JH
AF Wilkison, Bart D.
Sperling, Leonard C.
Spillane, Anne P.
Meyerle, Jon H.
TI How to Teach the Potassium Hydroxide Preparation: A Disappearing
Clinical Art Form
SO CUTIS
LA English
DT Article
AB Using potassium hydroxide (KOH) preparations in the diagnosis of superficial fungal infections is a technique that has been handed down from teacher to apprentice for more than 100 years. The technique is simple, accurate, and inexpensive; however, there is reason to believe it is falling to the wayside in favor of empiric treatment, especially in primary care settings. To continue the use of this valuable diagnostic aid, a system of teaching the KOH preparation to the next generation of physicians (ie, medical students, residents) is proposed with emphasis on facilitating the process by storing viable skin samples infected with dermatophytes for long periods of time. This technique obviates the need to find suitably infected patients before each teaching laboratory. This technique also is appropriate to refresh the skills of practicing physicians as they prepare for point-of-care testing assessments.
C1 [Wilkison, Bart D.] Brooke Army Med Ctr, San Antonio, TX USA.
[Sperling, Leonard C.; Meyerle, Jon H.] Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Dept Dermatol, Bethesda, MD 20814 USA.
[Spillane, Anne P.] Kimbrough Ambulatory Care Clin, Ft George G Meade, MD USA.
RP Meyerle, JH (reprint author), Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Dept Dermatol, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.
EM jon.meyerle@usuhs.edu
NR 8
TC 0
Z9 0
U1 1
U2 2
PU QUADRANT HEALTHCOM INC
PI PARSIPPANY
PA 7 CENTURY DRIVE, STE 302, PARSIPPANY, NJ 07054-4603 USA
SN 0011-4162
EI 2326-6929
J9 CUTIS
JI Cutis
PD AUG
PY 2015
VL 96
IS 2
BP 109
EP 112
PG 4
WC Dermatology
SC Dermatology
GA CP3CX
UT WOS:000359755500007
PM 26367748
ER
PT J
AU Robinson, RM
Kothera, CS
Wereley, NM
AF Robinson, Ryan M.
Kothera, Curt S.
Wereley, Norman M.
TI Variable Recruitment Testing of Pneumatic Artificial Muscles for Robotic
Manipulators
SO IEEE-ASME TRANSACTIONS ON MECHATRONICS
LA English
DT Article
DE Actuator; McKibben muscle; motor unit; pneumatic artificial muscle
(PAM); variable recruitment
ID MOTOR UNITS; ACTUATOR; SYSTEM; ARM; DESIGN; MODEL
AB This paper investigates the orderly recruitment of pneumatic artificial muscles for efficient torque production in a robotic manipulator. Pneumatic artificial muscles (PAMs) are arranged in a parallel bundle, and independently-controlled "motor units" are employed to imitate the structure and function of human skeletal muscle. Simulated cycling tests are conducted on a model of the robotic manipulator to quantify the benefits of variable recruitment, and experimental testing is performed to validate the simulated predictions. Results reveal a distinct relationship between recruitment and system efficiency. Key factors influencing the value of a variable recruitment strategy include nonlinear PAM bladder elasticity, pneumatic losses, and dissipative forces in the robotic joint. Recruitment guidelines are proposed to maximize efficiency over a range of payload masses. The potential challenges associated with maintaining smooth motion control during discrete transitions in recruitment are also identified and discussed.
C1 [Robinson, Ryan M.; Wereley, Norman M.] Univ Maryland, Dept Aerosp Engn, College Pk, MD 20742 USA.
[Kothera, Curt S.] InnoVital Syst Inc, Beltsville, MD 20705 USA.
RP Robinson, RM (reprint author), Army Res Lab, Adelphi, MD 20783 USA.
EM rymicro@umd.edu; curt@innovitalsystems.com; wereley@umd.edu
OI Wereley, Norman M. /0000-0002-9932-6988
FU U.S. Army Medical Research and Materiel Command [W81XWH-10-C-0014]
FX This work was supported in part by the U.S. Army Medical Research and
Materiel Command under Contract W81XWH-10-C-0014 (technical monitor: Dr.
G. Gilbert).
NR 41
TC 3
Z9 3
U1 2
U2 27
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 1083-4435
EI 1941-014X
J9 IEEE-ASME T MECH
JI IEEE-ASME Trans. Mechatron.
PD AUG
PY 2015
VL 20
IS 4
BP 1642
EP 1652
DI 10.1109/TMECH.2014.2341660
PG 11
WC Automation & Control Systems; Engineering, Manufacturing; Engineering,
Electrical & Electronic; Engineering, Mechanical
SC Automation & Control Systems; Engineering
GA CO6FJ
UT WOS:000359252300016
ER
PT J
AU Aita-Holmes, C
Liacouras, P
Wilson, WO
Grant, GT
AF Aita-Holmes, Cynthia
Liacouras, Peter
Wilson, William O., Jr.
Grant, Gerald T.
TI Digital capture, design, and manufacturing of an extraoral device for a
clarinet player with Bell's palsy
SO JOURNAL OF PROSTHETIC DENTISTRY
LA English
DT Article
ID LYME-DISEASE
AB An extraoral device was fabricated to assist a clarinet player with Bell's palsy. The device was fabricated by using stereophotogrammetry, digital design, and additive manufacturing technologies.
C1 [Aita-Holmes, Cynthia] US Army, Dent Corps, Naval Postgrad Dent Sch, Bethesda, MD USA.
[Liacouras, Peter] Walter Reed Natl Mil Med Ctr, Dept Radiol, 3D Med Applicat Ctr, Bethesda, MD USA.
[Wilson, William O., Jr.] Naval Postgrad Dent Sch, Dent Corps, Maxillofacial Prosthet, Bethesda, MD USA.
[Grant, Gerald T.] US Navy, Dent Corps, Walter Reed Natl Mil Med Ctr, Bethesda, MD 20084 USA.
RP Grant, GT (reprint author), Walter Reed Natl Mil Med Ctr, 8901 Wisconsin Ave, Bethesda, MD 20889 USA.
EM Gerald.t.grant.mil@health.mil
OI Aita-Holmes, Cynthia/0000-0001-5627-8405
NR 6
TC 1
Z9 1
U1 0
U2 1
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0022-3913
EI 1097-6841
J9 J PROSTHET DENT
JI J. Prosthet. Dent.
PD AUG
PY 2015
VL 114
IS 2
BP 297
EP 300
PG 4
WC Dentistry, Oral Surgery & Medicine
SC Dentistry, Oral Surgery & Medicine
GA CP1BT
UT WOS:000359611600023
PM 25985740
ER
PT J
AU McNesby, KL
Biss, MM
Benjamin, RA
Thompson, RA
Rozanski, A
AF McNesby, Kevin L.
Biss, Matthew M.
Benjamin, Richard A.
Thompson, Ronnie A.
Rozanski, Anthony
TI Chemical Imaging of Explosions - Mapping BO2 Light Emission
SO PROPELLANTS EXPLOSIVES PYROTECHNICS
LA English
DT Article
DE Boron; Ignition delay; Chemical imaging; Boron oxide
ID COMBUSTION; IGNITION
AB This work describes chemical imaging of BO2 formed during ballistic initiation of 1:1 by weight powder-mixtures of boron (B) and potassium nitrate (KNO3) contained within a polyethylene spherical projectile (25mm diameter). Initiation was achieved by impact of the gas-gun-launched B/KNO3-filled projectile with an anvil in a windowed, air-filled chamber. To monitor the subsequent chemical reaction, a two-camera, optically-filtered method to map discrete chemical emission from the BO2 molecule was used. This technique distinguishes incandescence of hot particles produced during the event from discrete chemical emission by BO2 near a wavelength of 546nanometers (nm). The dependence of delay in BO2 chemical emission (that exceeded particle incandescence) with impact velocity was investigated and chemical emission movies which ratio the intensity of discrete to thermal emission are discussed. Emission spectra (300-1000nm wavelength) were recorded during the impact event, and used to determine a grey-body temperature of the hot particles during the time when BO2 emission was most intense.
C1 [McNesby, Kevin L.; Biss, Matthew M.; Benjamin, Richard A.; Thompson, Ronnie A.] US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
[Rozanski, Anthony] Gen Sci Inc, Souderton, PA 18964 USA.
RP McNesby, KL (reprint author), US Army, Res Lab, Aberdeen Proving Ground, MD 21005 USA.
EM mcnesby@arl.army.mil
FU Army Research Laboratory (ARL) program on Innovation Research; Defense
Threat Reduction Agency (DTRA); Strategic Environmental Research and
Development Program (SERDP)
FX The authors would like to acknowledge the support of the Army Research
Laboratory (ARL) program on Innovation Research, the Defense Threat
Reduction Agency (DTRA) and the Strategic Environmental Research and
Development Program (SERDP).
NR 17
TC 1
Z9 1
U1 1
U2 4
PU WILEY-V C H VERLAG GMBH
PI WEINHEIM
PA BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY
SN 0721-3115
EI 1521-4087
J9 PROPELL EXPLOS PYROT
JI Propellants Explos. Pyrotech.
PD AUG
PY 2015
VL 40
IS 4
BP 539
EP 543
DI 10.1002/prep.201500106
PG 5
WC Chemistry, Applied; Engineering, Chemical
SC Chemistry; Engineering
GA CO7LY
UT WOS:000359341900015
ER
PT J
AU Yuen, WK
Du, K
Koloutsou-Vakakis, S
Rood, MJ
Kim, BJ
Kemme, MR
Hashmonay, RA
Meister, C
AF Yuen, Wangki
Du, Ke
Koloutsou-Vakakis, Sotiria
Rood, Mark J.
Kim, Byung J.
Kemme, Michael R.
Hashmonay, Ram A.
Meister, Chad
TI Fugitive Particulate Matter Emissions to the Atmosphere from Tracked and
Wheeled Vehicles in a Desert Region by Hybrid-Optical Remote Sensing
SO AEROSOL AND AIR QUALITY RESEARCH
LA English
DT Article
DE LIDAR; AP-42; PM10; PM2.5; Flux tower method
ID COMPLEX REFRACTIVE-INDEX; STATIONARY SHORT-TERM; MASS EMISSIONS;
AIR-POLLUTION; DUST; QUANTIFY; AEROSOLS; OPACITY; LIDAR
AB A hybrid-optical remote sensing (hybrid-ORS) method was developed to quantify mass emission factors (EFs) for fugitive particulate matter with aerodynamic diameters <= 10 mu m (PM10) and <= 2.5 mu m (PM2.5). In-situ range-resolved extinction coefficient and concurrent point measurements of PM10 and PM2.5 mass concentrations are used to quantify two-dimensional (2-D) PM10 and PM2.5 mass concentration profiles. Integration of each 2-D mass concentration profile with wind data, event duration, and source type provides the corresponding fugitive PM10 and PM2.5 EFs. This method was used to quantify EFs for fugitive PM10 and PM2.5 emitted from tracked and wheeled vehicles travelling on unpaved roads in a desert region. The EFs for tracked vehicles ranged from 206 g/km to 1,738 g/km for PM10 and from 78 g/km to 684 g/km for PM2.5, depending on vehicle speed and vehicle type. The EFs for the wheeled vehicle ranged from 223 g/km to 4,339 g/km for PM10 and from 44 g/km to 1,627 g/km for PM2.5. Field implementation of the hybrid-ORS method demonstrates that the method can rapidly capture multiple profiles of the PM plumes and is well suited for improved quantification of fugitive PM EFs from vehicles traveling on unpaved roads.
C1 [Yuen, Wangki; Koloutsou-Vakakis, Sotiria; Rood, Mark J.; Kim, Byung J.] Univ Illinois, Urbana, IL 61801 USA.
[Du, Ke] Univ Calgary, Calgary, AB T2N 1N4, Canada.
[Kim, Byung J.; Kemme, Michael R.] ERDC CERL, Champaign, IL 61826 USA.
[Hashmonay, Ram A.] Atmosfir Opt Ltd, Raleigh, NC 27617 USA.
[Meister, Chad] Ft Carson, Ft Carson, CO 80913 USA.
RP Rood, MJ (reprint author), Univ Illinois, 205 N Mathews Ave, Urbana, IL 61801 USA.
EM mrood@illinois.edu
RI Du, Ke/A-6649-2012
FU Department of Defense (DoD) Project [SI-1400]; Chinese Academy of
Sciences Visiting Professorship for Senior International Scientists
[2011T2Z17]
FX The authors thank the support from Department of Defense (DoD) Project
SI-1400 and Chinese Academy of Sciences Visiting Professorship for
Senior International Scientists, Grant 2011T2Z17. The authors also thank
DRI for providing global positioning system, DustTrak (TM), anemometer,
and wind vane data.
NR 31
TC 0
Z9 0
U1 3
U2 8
PU TAIWAN ASSOC AEROSOL RES-TAAR
PI TAICHUNG COUNTY
PA CHAOYANG UNIV TECH, DEPT ENV ENG & MGMT, PROD CTR AAQR, NO 168, JIFONG E
RD, WUFONG TOWNSHIP, TAICHUNG COUNTY, 41349, TAIWAN
SN 1680-8584
EI 2071-1409
J9 AEROSOL AIR QUAL RES
JI Aerosol Air Qual. Res.
PD AUG
PY 2015
VL 15
IS 4
BP 1613
EP 1626
DI 10.4209/aaqr.2014.12.0310
PG 14
WC Environmental Sciences
SC Environmental Sciences & Ecology
GA CO2PQ
UT WOS:000358999400039
ER
PT J
AU Seehusen, DA
Chaffee, DM
AF Seehusen, Dean A.
Chaffee, Donald M., III
TI The Epley Maneuver for Treatment of Benign Paroxysmal Positional Vertigo
SO AMERICAN FAMILY PHYSICIAN
LA English
DT Article
ID CANALITH REPOSITIONING PROCEDURE; TRIAL
C1 [Seehusen, Dean A.] Dwight D Eisenhower Army Med Ctr, Ft Gordon, GA 30905 USA.
[Chaffee, Donald M., III] Womack Army Med Ctr, Ft Bragg, NC USA.
RP Seehusen, DA (reprint author), Dwight D Eisenhower Army Med Ctr, Ft Gordon, GA 30905 USA.
NR 6
TC 0
Z9 0
U1 2
U2 5
PU AMER ACAD FAMILY PHYSICIANS
PI KANSAS CITY
PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA
SN 0002-838X
EI 1532-0650
J9 AM FAM PHYSICIAN
JI Am. Fam. Physician
PD AUG 1
PY 2015
VL 92
IS 3
BP 184
EP 185
PG 2
WC Primary Health Care; Medicine, General & Internal
SC General & Internal Medicine
GA CO1BL
UT WOS:000358887800003
PM 26280138
ER
PT J
AU Kundracik, F
Kocifaj, M
Videen, G
Klacka, J
AF Kundracik, Frantisek
Kocifaj, Miroslav
Videen, Gorden
Klacka, Jozef
TI Effect of charged-particle surface excitations on near-field optics
SO APPLIED OPTICS
LA English
DT Article
ID ELECTROMAGNETIC-WAVES; SCATTERING; NANOPARTICLES; SPHERES; LIGHT
AB The mechanism of charge on the near-field intensity distribution is revealed for metallic and dielectric particles with sizes ranging from 10 nm to 10 mu m. The theoretical foundation of near-field intensity perturbations is in the discontinuity of the tangential components of the magnetic fields on either side of the interface between the particle and its surrounding medium, since excess electrons form a thin metal-like layer with elevated conductivity. We have shown that the local fields alter marginally if charges are imposed on a surface of a metallic particle. But an intensity amplification is identified in the vicinity of charged dielectric particles with sizes smaller than the wavelength. Specifically, we have demonstrated that the electromagnetic field is amplified near the poles of the particle as a result of the oriented electric and incident fields. In contrast, a dielectric particle that is large compared to the wavelength becomes opaque with a deep shadow at the side opposite to the beam incidence. As a result, intensity damping is identified near a charged sphere in the geometric optics regime. At significant charge densities, the physical properties of a conductive layer play a dominant role in forming the 3D intensity distribution independent of conductivity or permittivity of the particle core. These findings suggest that some electrically chargeable particles have the potential to be used as optical devices with properties tunable through their net surface charge. (C) 2015 Optical Society of America
C1 [Kundracik, Frantisek; Kocifaj, Miroslav; Klacka, Jozef] Comenius Univ, Fac Math Phys & Informat, Bratislava 84248, Slovakia.
[Kocifaj, Miroslav] Slovak Acad Sci, ICA, Bratislava 84503, Slovakia.
[Videen, Gorden] US Army Res Lab, AMSRD ARL CI ES, Adelphi, MD 20783 USA.
[Videen, Gorden] Univ Cantabria, Dept Fis Aplicada, Fac Ciencias, Grp Opt, E-39005 Santander, Spain.
[Videen, Gorden] INTA, Madrid 28850, Spain.
RP Kocifaj, M (reprint author), Comenius Univ, Fac Math Phys & Informat, Bratislava 84248, Slovakia.
EM kocifaj@savba.sk
FU U.S. Army Research Laboratory (ARL) [W911NF-14-1-0601]; Slovak National
Grant Agency VEGA [2/0002/12]
FX U.S. Army Research Laboratory (ARL) (W911NF-14-1-0601); Slovak National
Grant Agency VEGA (2/0002/12).
NR 17
TC 4
Z9 4
U1 1
U2 8
PU OPTICAL SOC AMER
PI WASHINGTON
PA 2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 USA
SN 1559-128X
EI 2155-3165
J9 APPL OPTICS
JI Appl. Optics
PD AUG 1
PY 2015
VL 54
IS 22
BP 6674
EP 6681
DI 10.1364/AO.54.006674
PG 8
WC Optics
SC Optics
GA CO1UN
UT WOS:000358941200009
PM 26368079
ER
PT J
AU Schlader, ZJ
Gagnon, D
Rivas, E
Convertino, VA
Crandall, CG
AF Schlader, Zachary J.
Gagnon, Daniel
Rivas, Eric
Convertino, Victor A.
Crandall, Craig G.
TI Fluid restriction during exercise in the heat reduces tolerance to
progressive central hypovolaemia
SO EXPERIMENTAL PHYSIOLOGY
LA English
DT Article
ID BODY NEGATIVE-PRESSURE; CEREBRAL-BLOOD-FLOW; SIMULATED HEMORRHAGIC
CHALLENGE; ORTHOSTATIC TOLERANCE; HEMODYNAMIC-RESPONSES; STRESS; HUMANS;
REDUCTIONS; VELOCITY; VOLUME
AB New Findings
What is the central question of this study?
Interactions between dehydration, as occurs during exercise in the heat without fluid replacement, and hyperthermia on the ability to tolerate central hypovolaemia are unknown.
What is the main finding and its importance?
We show that inadequate fluid intake during exercise in the heat can impair tolerance to central hypovolaemia even when it elicits only mild dehydration. These findings suggest that hydration during physical work in the heat has important military and occupational relevance for protection against the adverse effects of a subsequent haemorrhagic injury.
This study tested the hypothesis that dehydration induced via exercise in the heat impairs tolerance to central hypovolaemia. Eleven male subjects (32 +/- 7years old, 81.5 +/- 11.1kg) walked (O-2 uptake 1.7 +/- 0.4lmin(-1)) in a 40 degrees C, 30% relative humidity environment on three occasions, as follows: (i)subjects walked for 90min, drinking water to offset sweat loss (Hydrated, n=11); (ii)water intake was restricted, and exercise was terminated when intestinal temperature increased to the same level as in the Hydrated trial (Isothermic Dehydrated, n=11); and (iii)water intake was restricted, and exercise duration was 90min (Time Match Dehydrated, n=9). For each trial, tolerance to central hypovolaemia was determined following exercise via progressive lower body negative pressure and quantified as time to presyncope. Increases in intestinal temperature prior to lower body negative pressure were not different (P=0.91) between Hydrated (1.1 +/- 0.4 degrees C) and Isothermic Dehydrated trials (1.1 +/- 0.4 degrees C), but both were lower than in the Time Match Dehydrated trial (1.7 +/- 0.5 degrees C, P<0.01). Prior to lower body negative pressure, body weight was unchanged in the Hydrated trial (-0.1 +/- 0.2%), but was reduced in Isothermic Dehydrated (-0.9 +/- 0.4%) and further so in Time Match Dehydrated trial (-1.9 +/- 0.6%, all P<0.01). Time to presyncope was greater in Hydrated (14.7 +/- 3.2min) compared with Isothermic Dehydrated (11.9 +/- 3.3min, P<0.01) and Time Match Dehydrated trials (10.2 +/- 1.6min, P=0.03), which were not different (P=0.19). These data indicate that inadequate fluid intake during exercise in the heat reduces tolerance to central hypovolaemia independent of increases in body temperature.
C1 [Schlader, Zachary J.; Gagnon, Daniel; Rivas, Eric; Crandall, Craig G.] Texas Hlth Presbyterian Hosp Dallas, Inst Exercise & Environm Med, Dallas, TX 75231 USA.
[Schlader, Zachary J.; Gagnon, Daniel; Rivas, Eric; Crandall, Craig G.] Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USA.
[Schlader, Zachary J.] SUNY Buffalo, Dept Exercise & Nutr Sci, Buffalo, NY 14260 USA.
[Rivas, Eric] Texas Womans Univ, Dept Kinesiol, Denton, TX 76204 USA.
[Convertino, Victor A.] US Army Inst Surg Res, San Antonio, TX USA.
RP Crandall, CG (reprint author), Texas Hlth Presbyterian Hosp Dallas, Inst Exercise & Environm Med, 7232 Greenville Ave, Dallas, TX 75231 USA.
EM craigcrandall@texashealth.org
OI Rivas, Eric/0000-0002-4657-8292; Gagnon, Daniel/0000-0001-5396-9489
FU Department of Defense [W81XWH-12-1-0152]; National Institutes of Health
[F32AG04328, HL61388]
FX This study was supported by awards from the Department of Defense
(W81XWH-12-1-0152 to C.G.C.) and National Institutes of Health
(F32AG04328 to Z.J.S. and HL61388 to C.G.C.).
NR 36
TC 2
Z9 2
U1 0
U2 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0958-0670
EI 1469-445X
J9 EXP PHYSIOL
JI Exp. Physiol.
PD AUG 1
PY 2015
VL 100
IS 8
BP 926
EP 934
DI 10.1113/EP085280
PG 9
WC Physiology
SC Physiology
GA CO7BK
UT WOS:000359312300007
PM 26096953
ER
PT J
AU Venkatesan, MM
AF Venkatesan, Malabi M.
TI L. lactis particles carrying Shigella antigens are protective in mice A
novel protein-based subunit Shigella vaccine candidate
SO IMMUNOLOGY AND CELL BIOLOGY
LA English
DT Editorial Material
ID CHILDREN; MUCOSAL; IPAD
C1 Walter Reed Army Inst Res, Bacterial Dis Branch, Silver Spring, MD 20910 USA.
RP Venkatesan, MM (reprint author), Walter Reed Army Inst Res, Bacterial Dis Branch, Silver Spring, MD 20910 USA.
EM malabi.venkatesan@us.army.mil
NR 10
TC 1
Z9 1
U1 0
U2 5
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0818-9641
EI 1440-1711
J9 IMMUNOL CELL BIOL
JI Immunol. Cell Biol.
PD AUG
PY 2015
VL 93
IS 7
BP 603
EP 604
DI 10.1038/icb.2015.56
PG 2
WC Cell Biology; Immunology
SC Cell Biology; Immunology
GA CO8MX
UT WOS:000359424600002
PM 26054727
ER
PT J
AU Biggs, AT
Cain, MS
Mitroff, SR
AF Biggs, Adam T.
Cain, Matthew S.
Mitroff, Stephen R.
TI Cognitive Training Can Reduce Civilian Casualties in a Simulated
Shooting Environment
SO PSYCHOLOGICAL SCIENCE
LA English
DT Article
DE shooting cognition; guns; attention; response inhibition; cognitive
training; civilian casualties
ID STOP-SIGNAL TASK; RESPONSE-INHIBITION; VISUAL SEARCHERS; WEAPON FOCUS;
PERFORMANCE; CORTEX; GAMES; GUNS; BIAS
AB Shooting a firearm involves a complex series of cognitive abilities. For example, locating an item or a person of interest requires visual search, and firing the weapon (or withholding a trigger squeeze) involves response execution (or inhibition). The present study used a simulated shooting environment to establish a relationship between a particular cognitive ability and a critical shooting error-response inhibition and firing on civilians, respectively. Individual-difference measures demonstrated, perhaps counterintuitively, that simulated civilian casualties were not related to motor impulsivity (i.e., an itchy trigger finger) but rather to an individual's cognitive ability to withhold an already initiated response (i.e., an itchy brain). Furthermore, active-response-inhibition training reduced simulated civilian casualties, which revealed a causal relationship. This study therefore illustrates the potential of using cognitive training to possibly improve shooting performance, which might ultimately provide insight for military and law-enforcement personnel.
C1 [Biggs, Adam T.; Mitroff, Stephen R.] Duke Univ, Ctr Cognit Neurosci, Durham, NC 27708 USA.
[Cain, Matthew S.] US Army, Natick Soldier Res Dev, Natick, MA 01760 USA.
RP Biggs, AT (reprint author), Duke Univ, Ctr Cognit Neurosci, B203 Levine Sci Res Ctr,Box 90999, Durham, NC 27708 USA.
EM adam.t.biggs@gmail.com
OI Cain, Matthew/0000-0002-3305-0464
FU Army Research Office [W911NF-13-1-0480]
FX This research was funded by the Army Research Office under Contract No.
W911NF-13-1-0480.
NR 43
TC 1
Z9 1
U1 6
U2 12
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0956-7976
EI 1467-9280
J9 PSYCHOL SCI
JI Psychol. Sci.
PD AUG
PY 2015
VL 26
IS 8
BP 1164
EP 1176
DI 10.1177/0956797615579274
PG 13
WC Psychology, Multidisciplinary
SC Psychology
GA CO6JJ
UT WOS:000359262700002
PM 26170262
ER
PT J
AU Ender, MG
Rohall, DE
Matthews, MD
AF Ender, Morten G.
Rohall, David E.
Matthews, Michael D.
TI Intersecting Identities: Race, Military Affiliation, and Youth Attitudes
towards War
SO WAR & SOCIETY
LA English
DT Article
DE African-Americans; war; race/ethnicity; attitudes; US military; Iraq;
Afghanistan; college undergraduates
ID PUBLIC-OPINION; SELF-SELECTION; GENDER; WEST; IRAQ
AB African-Americans in the U.S. military encompass at least two distinct identity groups: a racial status associated with lower support for the wars in Afghanistan and Iraq, and a military status which tends to be more 'hawkish' in perspective. This study examines the intersection of these two status characteristics utilizing survey data of American military academy cadets, Reserve Officer Training Corp (ROTC) cadets, and civilian students (n = 5,051). Majorities of military cadets, regardless of race, supported both of these wars more than their civilian counterparts, but African-Americans are significantly less supportive of the wars relative to their peers within each group. African-American cadets support both wars less so than whites and cadets of other races, but African-American cadets supported both wars more than African-American civilians. It appears that racial and military affiliations combine to yield a unique perspective on war, adapting elements of both statuses. These findings support the concept of intersectionality.
C1 [Ender, Morten G.] US Mil Acad, Sociol, Dept Behav Sci & Leadership, West Point, NY USA.
[Rohall, David E.] Missouri State Univ, Dept Sociol & Anthropol, Springfield, MO USA.
[Matthews, Michael D.] US Mil Acad, Engn Psychol, West Point, NY 11012 USA.
RP Matthews, MD (reprint author), US Mil Acad, Engn Psychol, West Point, NY 11012 USA.
EM morten.ender@usma.edu; DRohall@MissouriState.edu; mike.matthews@usma.edu
NR 44
TC 0
Z9 0
U1 0
U2 8
PU MANEY PUBLISHING
PI LEEDS
PA STE 1C, JOSEPHS WELL, HANOVER WALK, LEEDS LS3 1AB, W YORKS, ENGLAND
SN 0729-2473
EI 2042-4345
J9 WAR SOC
JI War Soc.
PD AUG
PY 2015
VL 34
IS 3
BP 230
EP 246
DI 10.1179/0729247315Z.00000000056
PG 17
WC History
SC History
GA CN8CW
UT WOS:000358666400004
ER
PT J
AU Roy, DC
Tomblyn, S
Burmeister, DM
Wrice, NL
Becerra, SC
Burnett, LR
Saul, JM
Christy, RJ
AF Roy, Daniel C.
Tomblyn, Seth
Burmeister, David M.
Wrice, Nicole L.
Becerra, Sandra C.
Burnett, Luke R.
Saul, Justin M.
Christy, Robert J.
TI Ciprofloxacin-Loaded Keratin Hydrogels Prevent Pseudomonas aeruginosa
Infection and Support Healing in a Porcine Full-Thickness Excisional
Wound
SO ADVANCES IN WOUND CARE
LA English
DT Article
ID RESISTANT STAPHYLOCOCCUS-AUREUS; SILVER SULFADIAZINE;
CONTROLLED-RELEASE; CYSTIC-FIBROSIS; SKIN; BIOMATERIALS; MANAGEMENT;
DRESSINGS; MODEL; BURNS
AB Objective: Cutaneous wound infection can lead to impaired healing, multiple surgical procedures, and increased hospitalization time. We tested the effectiveness of keratin-based hydrogels (termed "keratose'') loaded with ciprofloxacin to inhibit infection and support healing when topically administered to porcine excision wounds infected with Pseudomonas aeruginosa.
Approach: Using a porcine excisional wound model, 10 mm full-thickness wounds were inoculated with 10(6) colony-forming units of P. aeruginosa and treated on days 1 and 3 postinoculation with ciprofloxacin-loaded keratose hydrogels. Bacteria enumeration and wound healing were assessed on days 3, 7, and 11 postinjury.
Results: Ciprofloxacin-loaded keratose hydrogels reduced the amount of P. aeruginosa in the wound bed by 99.9% compared with untreated wounds on days 3, 7, and 11 postinjury. Ciprofloxacin-loaded keratose hydrogels displayed decreased wound contraction and reepithelialization at day 7 postinjury. By day 11, wounds treated with ciprofloxacin-keratose hydrogels contained collagen-rich granulation tissue and myofibroblasts. Wounds treated with ciprofloxacin-loaded keratose hydrogels exhibited a transient increase in macrophages in the wound bed at day 7 postinjury that subsided by day 11.
Innovation: Current therapies for wound infection include systemic antibiotics, which could lead to antibiotic resistance, and topical antimicrobial treatments, which require multiple applications and can delay healing. Here, we show that ciprofloxacin-loaded keratose hydrogels inhibit cutaneous wound infection without interfering with key aspects of the healing process including granulation tissue deposition and remodeling.
Conclusions: Ciprofloxacin-loaded keratose hydrogels have the potential to serve as a point-of-injury antibiotic therapy that prevents infection and supports healing following cutaneous injury.
C1 [Roy, Daniel C.] US Army Inst Surg Res, Ft Sam Houston, TX USA.
[Burmeister, David M.; Wrice, Nicole L.; Becerra, Sandra C.] US Army Inst Surg Res, Lab Dr Robert J Christy, Ft Sam Houston, TX USA.
[Christy, Robert J.] US Army Inst Surg Res, Extrem Trauma Res & Regenerat Med, Ft Sam Houston, TX USA.
[Roy, Daniel C.; Tomblyn, Seth; Burnett, Luke R.] KeraNetics LLC, Winston Salem, NC USA.
[Saul, Justin M.] Miami Univ, Dept Chem Paper & Biomed Engn, Oxford, OH 45056 USA.
RP Christy, RJ (reprint author), US Army Inst Surg Res, Extrem Trauma Res & Regenerat Med, 3698 Chambers Pass,BHT1 Bldg 3611, Jbsa Ft Sam Houston, TX 78234 USA.
EM robert.j.christy12.civ@mail.mil
RI Saul, Justin/I-1765-2016
NR 53
TC 2
Z9 3
U1 0
U2 4
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2162-1918
EI 2162-1934
J9 ADV WOUND CARE
JI Adv. Wound Care
PD AUG
PY 2015
VL 4
IS 8
BP 457
EP 468
DI 10.1089/wound.2014.0576
PG 12
WC Dermatology
SC Dermatology
GA CL8YW
UT WOS:000357261900003
ER
PT J
AU Cochet, AA
Cochet, AE
Francis, JM
AF Cochet, Anthony A., Jr.
Cochet, Allyson E.
Francis, James M.
TI Eosinophilic Esophagitis with Dysphagia and Food Impaction in a Young
Adult
SO AEROSPACE MEDICINE AND HUMAN PERFORMANCE
LA English
DT Article
DE eosinophilic esophagitis; dysphagia; impaction
ID CONSENSUS RECOMMENDATIONS; FOREIGN-BODIES; MANAGEMENT; DIAGNOSIS;
CHILDREN; COMPLICATIONS; RISK; DIET
AB BACKGROUND: Eosinophilic esophagitis (EoE) is an emerging esophageal disease associated with dysphagia and food impaction. Practice guidelines have only recently been developed. It affects 1/1000 individuals, predominantly young men. As this demographic represents a substantial portion of the military aviation population, aerospace medicine clinicians should be familiar with this diagnosis when evaluating dysphagia or impactions.
CASE REPORT: A 23-yr-old Caucasian man, a U.S. Air Force air traffic controller, presented to. Flight Medicine following an episode of food impaction requiring evaluation in the local emergency department.The patient reported a 5-yr history of recurrent episodes of food lodging in his throat, requiring fluid and body repositioning for resolution. Medical history was significant for eczema. Upper endoscopy revealed an abnormal esophagus with macroscopic features of EoE and biopsies were also consistent with EoE. After further work-up, the patient was diagnosed with EoE and treated. Significant symptom improvement was noted after 2 mo of therapy.
DISCUSSION: This case outlines the evaluation of food impaction as well as the diagnostic criteria for EoE, which is a disease that affects patients with demographics common to the military aviation community. As the diagnostic and treatment guidelines for EoE are relatively new, it may easily be overlooked by the primary care physician, causing a delay in subspecialist consultation, thus delaying treatment. EoE is a condition with symptoms that pose high risk to the performance of aircrew duties; therefore, flight surgeons must be familiar with the aeromedical standards that accompany this diagnosis.
C1 [Cochet, Anthony A., Jr.] 47th Med Grp, Laughlin Afb, TX 78843 USA.
[Cochet, Allyson E.; Francis, James M.] Brooke Army Med Ctr, Dept Gastroenterol, Ft Sam Houston, TX 78234 USA.
RP Cochet, AA (reprint author), 47th Med Grp, Laughlin Afb, TX 78843 USA.
EM cochetaa@gmail.com
NR 21
TC 0
Z9 0
U1 3
U2 4
PU AEROSPACE MEDICAL ASSOC
PI ALEXANDRIA
PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA
SN 2375-6314
EI 2375-6322
J9 AEROSP MED HUM PERF
JI Aerosp. Med.Hum. Perform.
PD AUG
PY 2015
VL 86
IS 8
BP 742
EP 746
DI 10.3357/AMHP.4236.2015
PG 5
WC Biophysics; Public, Environmental & Occupational Health; Medicine,
Research & Experimental
SC Biophysics; Public, Environmental & Occupational Health; Research &
Experimental Medicine
GA CN5LV
UT WOS:000358471700009
PM 26387899
ER
PT J
AU Cerutti, F
Kaplan, LM
Norman, TJ
Oren, N
Toniolo, A
AF Cerutti, Federico
Kaplan, Lance M.
Norman, Timothy J.
Oren, Nir
Toniolo, Alice
TI Subjective logic operators in trust assessment: an empirical study
SO INFORMATION SYSTEMS FRONTIERS
LA English
DT Article
DE Trust and reputation; Information fusion; Uncertain reasoning
AB Computational trust mechanisms aim to produce trust ratings from both direct and indirect information about agents' behaviour. Subjective Logic (SL) has been widely adopted as the core of such systems via its fusion and discount operators. In recent research we revisited the semantics of these operators to explore an alternative, geometric interpretation. In this paper we present principled desiderata for discounting and fusion operators in SL. Building upon this we present operators that satisfy these desirable properties, including a family of discount operators. We then show, through a rigorous empirical study, that specific, geometrically interpreted, operators significantly outperform standard SL operators in estimating ground truth. These novel operators offer real advantages for computational models of trust and reputation, in which they may be employed without modifying other aspects of an existing system.
C1 [Cerutti, Federico; Norman, Timothy J.; Oren, Nir; Toniolo, Alice] Univ Aberdeen, Kings Coll, Sch Nat & Comp Sci, Aberdeen AB24 3UE, Scotland.
[Kaplan, Lance M.] US Army Res Lab, Adelphi, MD USA.
RP Cerutti, F (reprint author), Univ Aberdeen, Kings Coll, Sch Nat & Comp Sci, Aberdeen AB24 3UE, Scotland.
EM f.cerutti@abdn.ac.uk; lkaplan@ieee.org; t.j.norman@abdn.ac.uk;
n.oren@abdn.ac.uk; a.toniolo@abdn.ac.uk
OI Norman, Timothy/0000-0002-6387-4034
FU US Army Research laboratory; UK Ministry of Defence [W911NF-06-3-0001]
FX Research was sponsored by US Army Research laboratory and the UK
Ministry of Defence and was accomplished under Agreement Number
W911NF-06-3-0001. The views and conclusions contained in this document
are those of the authors and should not be interpreted as representing
the official policies, either expressed or implied, of the US Army
Research Laboratory, the U.S. Government, the UK Ministry of Defense, or
the UK Government. The US and UK Governments are authorized to reproduce
and distribute reprints for Government purposes notwithstanding any
copyright notation hereon.
NR 21
TC 1
Z9 2
U1 0
U2 3
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1387-3326
EI 1572-9419
J9 INFORM SYST FRONT
JI Inf. Syst. Front.
PD AUG
PY 2015
VL 17
IS 4
SI SI
BP 743
EP 762
DI 10.1007/s10796-014-9522-5
PG 20
WC Computer Science, Information Systems; Computer Science, Theory &
Methods
SC Computer Science
GA CN8CH
UT WOS:000358664600004
ER
PT J
AU Bhattacharyya, S
Zhang, XL
Feferman, L
Johnson, D
Tortella, FC
Guizzetti, M
Tobacman, JK
AF Bhattacharyya, Sumit
Zhang, Xiaolu
Feferman, Leo
Johnson, David
Tortella, Frank C.
Guizzetti, Marina
Tobacman, Joanne K.
TI Decline in arylsulfatase B and Increase in chondroitin
4-sulfotransferase combine to increase chondroitin 4-sulfate in
traumatic brain injury
SO JOURNAL OF NEUROCHEMISTRY
LA English
DT Article
DE arylsulfatase B; astrocytes; chondroitin 4-sulfate; CHST11;
glycosaminoglycans; neurocan
ID ENZYME REPLACEMENT THERAPY; SULFATE PROTEOGLYCANS; REACTIVE
ASTROGLIOSIS; MUCOPOLYSACCHARIDOSIS-VI; OXYGEN-TENSION; GROWTH-FACTOR;
GLIAL SCAR; IN-VITRO; ASTROCYTES; MODEL
AB In an established rat model of penetrating ballistic-like brain injury (PBBI), arylsulfatase B (ARSB; N-acetylgalactosamine 4-sulfatase) activity was significantly reduced at the ipsilateral site of injury, but unaffected at the contralateral site or in sham controls. In addition, the ARSB substrate chondroitin 4-sulfate (C4S) and total sulfated glycosaminoglycans increased. The mRNA expression of chondroitin 4-sulfotransferase 1 (C4ST1; CHST11) and the sulfotransferase activity rose at the ipsilateral site of injury (PBBI-I), indicating contributions from both increased production and reduced degradation to the accumulation of C4S. In cultured, fetal rat astrocytes, following scratch injury, the ARSB activity declined and the nuclear hypoxia inducible factor-1 increased significantly. In contrast, sulfotransferase activity and chondroitin 4-sulfotransferase expression increased following astrocyte exposure to TGF-1, but not following scratch. These different pathways by which C4S increased in the cell preparations were both evident in the response to injury in the PBBI-I model. Hence, findings support effects of injury because of mechanical disruption inhibiting ARSB and to chemical mediation by TGF-1 increasing CHST11 expression and sulfotransferase activity. The increase in C4S following traumatic brain injury is because of contributions from impaired degradation and enhanced synthesis of C4S which combine in the pathogenesis of the glial scar.
C1 [Bhattacharyya, Sumit; Feferman, Leo; Tobacman, Joanne K.] Univ Illinois, Dept Med, Chicago, IL USA.
[Bhattacharyya, Sumit; Zhang, Xiaolu; Feferman, Leo; Guizzetti, Marina; Tobacman, Joanne K.] Jesse Brown VA Med Ctr, Chicago, IL USA.
[Zhang, Xiaolu; Guizzetti, Marina] Univ Illinois, Dept Psychiat, Chicago, IL 60612 USA.
[Johnson, David; Tortella, Frank C.] Walter Reed Army Inst Res, Silver Spring, MD USA.
[Guizzetti, Marina] Oregon Hlth & Sci Univ, Portland, OR 97201 USA.
[Guizzetti, Marina] VA Portland Hlth Care Syst, Portland, OR USA.
RP Tobacman, JK (reprint author), 840 S Wood St,CSN 440,MC 718, Chicago, IL 60612 USA.
EM jkt@uic.edu
FU NIH [CTSA ULI RR029879]; NIH/NIAAA [AA021876]; VHA [I01BX001819]
FX This work was supported by the NIH CTSA ULI RR029879 (to JKT), by
NIH/NIAAA AA021876 (to MG), and by VHA I01BX001819 (to MG). The authors
declare no competing financial interests.
NR 51
TC 2
Z9 2
U1 1
U2 9
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-3042
EI 1471-4159
J9 J NEUROCHEM
JI J. Neurochem.
PD AUG
PY 2015
VL 134
IS 4
BP 728
EP 739
DI 10.1111/jnc.13156
PG 12
WC Biochemistry & Molecular Biology; Neurosciences
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA CN8KI
UT WOS:000358688700012
PM 25943740
ER
PT J
AU Koppenhaver, SL
Walker, MJ
Smith, RW
Booker, JM
Walkup, ID
Su, J
Hebert, JJ
Flynn, T
AF Koppenhaver, Shane L.
Walker, Michael J.
Smith, Ryan W.
Booker, Jacquelynn M.
Walkup, Isaac D.
Su, Jonathan
Hebert, Jeffrey J.
Flynn, Timothy
TI Baseline Examination Factors Associated With Clinical Improvement After
Dry Needling in Individuals With Low Back Pain
SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY
LA English
DT Article
DE clinical prediction rule; lumbar spine; Oswestry; trigger point
ID MYOFASCIAL TRIGGER POINT; PREDICTION RULE; IDENTIFY PATIENTS; SPINAL
MANIPULATION; PRIMARY-CARE; NECK PAIN; ACUPUNCTURE; MANAGEMENT;
VALIDITY; RELIABILITY
AB STUDY DESIGN: Quasi-experimental.
OBJECTIVES: To explore for associations between demographic, patient history, and physical examination variables and short-term improvement in self-reported disability following dry needling therapy performed on individuals with low back pain (LBP).
BACKGROUND: Dry needling is an intervention used with increasing frequency in patients with LBP; however, the characteristics of patients who are most likely to respond are not known.
METHODS: Seventy-two volunteers with mechanical LBP participated in the study. Potential prognostic factors were collected from baseline questionnaires, patient history, and physical examination tests. Treatment consisted of dry needling to the lumbar multifidus muscles bilaterally, administered during a single treatment session. Improvement was based on percent change on the Oswestry Disability index at 1 week. The univariate and multivariate associations between 33 potential prognostic factors and improved disability were assessed with correlation coefficients and multivariate linear regression.
RESULTS: Increased LBP with the multifidus lift test (r(pb) = 0.31, P = .01) or during passive hip flexion performed with the patient supine (r(pb) = 0.23, P = .06), as well as positive beliefs about acupuncture/dry needling (rho = 0.22, P = .07), demonstrated univariate associations with Oswestry Disability Index improvement. Aggravation of LBP with standing (r(pb) = -0.27, P = .03), presence of leg pain (r(pb) = -0.29, P = .02), and any perception of hypermobility in the lumbar spine fro = -0.21, P = .09) were associated with less improvement. The multivariate model identified 2 predictors of improved disability with dry needling: pain with the multifidus lift test and no aggravation with standing (R-2 = 0.16, P = .01).
CONCLUSION: Increased LBP with the multifidus lift test was the strongest predictor of improved disability after dry needling, suggesting that the finding of pain during muscle contraction should be studied in future dry needling studies.
LEVEL OF EVIDENCE: Prognosis, level 1b.
C1 [Koppenhaver, Shane L.; Smith, Ryan W.; Booker, Jacquelynn M.; Walkup, Isaac D.; Su, Jonathan] Baylor Univ, US Army, Doctoral Program Phys Therapy, San Antonio, TX USA.
[Walker, Michael J.; Flynn, Timothy] South Coll Doctor Phys Therapy Program, Knoxville, TN USA.
[Hebert, Jeffrey J.] Murdoch Univ, Sch Psychol & Exercise Sci, Perth, WA, Australia.
RP Koppenhaver, SL (reprint author), 3630 Stanley Rd,Bldg 2841,Suite 1301, Ft Sam Houston, TX 78234 USA.
EM shanekoppenhaver@mac.com
OI Hebert, Jeffrey/0000-0002-6959-325X
NR 58
TC 1
Z9 1
U1 2
U2 22
PU J O S P T,
PI ALEXANDRIA
PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA
SN 0190-6011
J9 J ORTHOP SPORT PHYS
JI J. Orthop. Sports Phys. Ther.
PD AUG
PY 2015
VL 45
IS 8
BP 604
EP 612
DI 10.2519/jospt.2015.5801
PG 9
WC Orthopedics; Rehabilitation; Sport Sciences
SC Orthopedics; Rehabilitation; Sport Sciences
GA CN8PH
UT WOS:000358702600005
PM 26110549
ER
PT J
AU Mason, JS
Crowell, MS
Goss, DL
AF Mason, John S.
Crowell, Michael S.
Goss, Donald L.
TI Fracture of the Scaphoid During a Bench-Press Exercise
SO JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY
LA English
DT Editorial Material
C1 [Mason, John S.; Crowell, Michael S.; Goss, Donald L.] Keller Army Community Hosp, US Army Baylor Univ Sports Phys Therapy Doctoral, West Point, NY 10996 USA.
RP Mason, JS (reprint author), Keller Army Community Hosp, US Army Baylor Univ Sports Phys Therapy Doctoral, West Point, NY 10996 USA.
NR 0
TC 0
Z9 0
U1 0
U2 2
PU J O S P T,
PI ALEXANDRIA
PA 1111 NORTH FAIRFAX ST, STE 100, ALEXANDRIA, VA 22314-1436 USA
SN 0190-6011
J9 J ORTHOP SPORT PHYS
JI J. Orthop. Sports Phys. Ther.
PD AUG
PY 2015
VL 45
IS 8
BP 642
EP 642
DI 10.2519/jospt.2015.0408
PG 1
WC Orthopedics; Rehabilitation; Sport Sciences
SC Orthopedics; Rehabilitation; Sport Sciences
GA CN8PH
UT WOS:000358702600010
PM 26232322
ER
PT J
AU Rerucha, C
Runser, L
Ee, J
Hersey, E
AF Rerucha, Caitlyn
Runser, Lloyd
Ee, Julianna
Hersey, Elizabeth
TI MILITARY HEALTHCARE PROVIDERS' KNOWLEDGE AND COMFORT REGARDING THE
MEDICAL CARE OF ACTIVE DUTY LESBIAN, GAY, AND BISEXUAL PATIENTS
SO JOURNAL OF SEXUAL MEDICINE
LA English
DT Meeting Abstract
DE US military; lesbian; gay; bisexual service members; primary care
C1 [Rerucha, Caitlyn] Carl R Darnall Army Med Ctr, Family Med Residency, Ft Hood, TX USA.
[Runser, Lloyd; Ee, Julianna; Hersey, Elizabeth] Womack Army Med Ctr, Family Med Residency, Ft Bragg, NC USA.
NR 0
TC 0
Z9 0
U1 2
U2 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1743-6095
EI 1743-6109
J9 J SEX MED
JI J. Sex. Med.
PD AUG
PY 2015
VL 12
SU 5
SI SI
BP 346
EP 346
PG 1
WC Urology & Nephrology
SC Urology & Nephrology
GA CN5SA
UT WOS:000358488600195
ER
PT J
AU Hoge, CW
Rye, CB
AF Hoge, Charles W.
Rye, Colleen B.
TI Efficacy and challenges of in-home telepsychotherapy
SO LANCET PSYCHIATRY
LA English
DT Editorial Material
ID POSTTRAUMATIC-STRESS-DISORDER; FACE-TO-FACE; TRIAL; CARE; TELEMEDICINE;
THERAPY
C1 [Hoge, Charles W.] Walter Reed Army Inst Res, Ctr Psychiat & Neurosci, Silver Spring, MD 20910 USA.
[Rye, Colleen B.] Off Army Surgeon Gen, Falls Church, VA USA.
RP Hoge, CW (reprint author), Walter Reed Army Inst Res, Ctr Psychiat & Neurosci, Silver Spring, MD 20910 USA.
EM charles.w.hoge.civ@mail.mil
NR 9
TC 1
Z9 1
U1 1
U2 1
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 2215-0374
J9 LANCET PSYCHIAT
JI Lancet Psychiatry
PD AUG
PY 2015
VL 2
IS 8
BP 668
EP 669
DI 10.1016/S2215-0366(15)00226-6
PG 2
WC Psychiatry
SC Psychiatry
GA CN9CH
UT WOS:000358743200004
PM 26249278
ER
PT J
AU Akers, KS
Shields, BA
Akers, ME
Mende, K
Beckius, ML
Murray, CK
Chung, KK
AF Akers, Kevin S.
Shields, Beth A.
Akers, Mary E.
Mende, Katrin
Beckius, Miriam L.
Murray, Clinton K.
Chung, Kevin K.
TI Microbial Contamination of Enteral Nutrition Mixtures in a Hyperthermal
Environment: A Follow-Up Investigation
SO NUTRITION IN CLINICAL PRACTICE
LA English
DT Letter
ID BACTERIAL-CONTAMINATION; FEEDING FORMULAS; BURN PATIENTS; CARE
C1 [Akers, Kevin S.; Akers, Mary E.; Chung, Kevin K.] US Army Inst Surg Res, Ft Sam Houston, TX 78234 USA.
[Akers, Kevin S.; Murray, Clinton K.; Chung, Kevin K.] Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA.
[Shields, Beth A.; Mende, Katrin; Murray, Clinton K.] San Antonio Mil Med Ctr, Ft Sam Houston, TX USA.
[Mende, Katrin] Uniformed Serv Univ Hlth Sci, Infect Dis Clin Res Program, Bethesda, MD 20814 USA.
[Beckius, Miriam L.] Brooke Army Med Ctr, Dept Clin Invest, Ft Sam Houston, TX 78234 USA.
RP Akers, KS (reprint author), US Army Inst Surg Res, Ft Sam Houston, TX 78234 USA.
NR 14
TC 0
Z9 0
U1 1
U2 2
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0884-5336
EI 1941-2452
J9 NUTR CLIN PRACT
JI Nutr. Clin. Pract.
PD AUG
PY 2015
VL 30
IS 4
BP 582
EP 584
DI 10.1177/0884533615586203
PG 3
WC Nutrition & Dietetics
SC Nutrition & Dietetics
GA CN5DG
UT WOS:000358449400016
PM 26206953
ER
PT J
AU Perry, J
Stankorb, SM
Salgueiro, M
AF Perry, Jeffery
Stankorb, Susan M.
Salgueiro, Marybeth
TI Author's Response to "Microbial Contamination of Enteral Nutrition
Mixtures in a Hyperthermal Environment: A Follow-Up Investigation"
SO NUTRITION IN CLINICAL PRACTICE
LA English
DT Letter
ID VENTILATOR-ASSOCIATED PNEUMONIA; BURN PATIENTS; CARE; GUIDELINES;
SUPPORT; INFECTION; RECOMMENDATIONS; MANAGEMENT; THERAPY; PATIENT
C1 [Perry, Jeffery] David Grant Med Ctr, Mil Baylor Grad Program Nutr, Travis AFB, CA 94535 USA.
[Stankorb, Susan M.] Brooke Army Med Ctr, Mil Baylor Grad Program Nutr, San Antonio, TX USA.
[Salgueiro, Marybeth] William Beaumont Army Med Ctr, Mil Baylor Grad Program Nutr, El Paso, TX USA.
RP Perry, J (reprint author), David Grant Med Ctr, Mil Baylor Grad Program Nutr, Travis AFB, CA 94535 USA.
NR 29
TC 0
Z9 0
U1 0
U2 1
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0884-5336
EI 1941-2452
J9 NUTR CLIN PRACT
JI Nutr. Clin. Pract.
PD AUG
PY 2015
VL 30
IS 4
BP 585
EP 588
DI 10.1177/0884533615586204
PG 4
WC Nutrition & Dietetics
SC Nutrition & Dietetics
GA CN5DG
UT WOS:000358449400017
PM 26206954
ER
PT J
AU Mitrophanov, AY
Rosendaal, FR
Reifman, J
AF Mitrophanov, Alexander Y.
Rosendaal, Frits R.
Reifman, Jaques
TI Mechanistic Modeling of the Effects of Acidosis on Thrombin Generation
SO ANESTHESIA AND ANALGESIA
LA English
DT Article
ID RECOMBINANT FACTOR VIIA; COMPUTATIONAL ANALYSIS; BLOOD-COAGULATION;
COAGULOPATHY; HYPOTHERMIA; PH; TEMPERATURE; SWINE; DEPENDENCE
AB BACKGROUND: Acidosis, a frequent complication of trauma and complex surgery, results from tissue hypoperfusion and IV resuscitation with acidic fluids. While acidosis is known to inhibit the function of distinct enzymatic reactions, its cumulative effect on the blood coagulation system is not fully understood. Here, we use computational modeling to test the hypothesis that acidosis delays and reduces the amount of thrombin generation in human blood plasma. Moreover, we investigate the sensitivity of different thrombin generation parameters to acidosis, both at the individual and population level.
METHODS: We used a kinetic model to simulate and analyze the generation of thrombin and thrombin-antithrombin complexes (TAT), which were the end points of this study. Large groups of temporal thrombin and TAT trajectories were simulated and used to calculate quantitative parameters, such as clotting time (CT), thrombin peak time, maximum slope of the thrombin curve, thrombin peak height, area under the thrombin trajectory (AUC), and prothrombin time. The resulting samples of parameter values at different pH levels were compared to assess the acidosis-induced effects. To investigate intersubject variability, we parameterized the computational model using the data on clotting factor composition for 472 subjects from the Leiden Thrombophilia Study. To compare acidosis-induced relative parameter changes in individual (virtual) subjects, we estimated the probabilities of relative change patterns by counting the pattern occurrences in our virtual subjects. Distribution overlaps for thrombin generation parameters at distinct pH levels were quantified using the Bhattacharyya coefficient.
RESULTS: Acidosis in the range of pH 6.9 to 7.3 progressively increased CT, thrombin peak time, AUC, and prothrombin time, while decreasing maximum slope of the thrombin curve and thrombin peak height (P < 10(-5)). Acidosis delayed the onset and decreased the amount of TAT generation (P < 10(-5)). As a measure of intrasubject variability, maximum slope of the thrombin curve and CT displayed the largest and second-largest acidosis-induced relative changes, and AUC displayed the smallest relative changes among all thrombin generation parameters in our virtual subject group (1-sided 95% lower confidence limit on the fraction of subjects displaying the patterns, 0.99). As a measure of intersubject variability, the overlaps between the maximum slope of the thrombin curve distributions at acidotic pH levels with the maximum slope of the thrombin curve distribution at physiological pH level systematically exceeded analogous distribution overlaps for CT, thrombin peak time, and prothrombin time.
CONCLUSIONS: Acidosis affected all quantitative parameters of thrombin and TAT generation. While maximum slope of the thrombin curve showed the highest sensitivity to acidosis at the individual-subject level, it may be outperformed by CT, thrombin peak time, and prothrombin time as an indicator of acidosis at the subject-group level.
C1 [Mitrophanov, Alexander Y.; Reifman, Jaques] DoD Biotechnol High Performance Comp Software App, Ft Detrick, MD USA.
[Mitrophanov, Alexander Y.; Reifman, Jaques] US Army Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Ft Detrick, MD USA.
[Rosendaal, Frits R.] Leiden Univ, Med Ctr, Dept Clin Epidemiol, Leiden, Netherlands.
[Rosendaal, Frits R.] Leiden Univ, Med Ctr, Dept Thrombosis & Haemostasis, Leiden, Netherlands.
RP Reifman, J (reprint author), ATTN MCMR TT, DoD Biotechnol High Performance Comp Software App, Telemed & Adv Technol Res Ctr, US Army Med Res & Mat Command, 504 Scott St, Ft Detrick, MD 21702 USA.
EM jaques.reifman.civ@mail.mil
FU Network Science Initiative of the U.S. Army, U.S. Army Medical Research
and Materiel Command, Ft. Detrick, MD; Netherlands Heart Foundation
[89-063]
FX AYM and JR were supported by the Network Science Initiative of the U.S.
Army, U.S. Army Medical Research and Materiel Command, Ft. Detrick, MD.
The Leiden Thrombophilia Study, completed previously (FRR), was funded
by the Netherlands Heart Foundation (89-063).
NR 39
TC 1
Z9 1
U1 2
U2 11
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0003-2999
J9 ANESTH ANALG
JI Anesth. Analg.
PD AUG
PY 2015
VL 121
IS 2
BP 278
EP 288
DI 10.1213/ANE.0000000000000733
PG 11
WC Anesthesiology
SC Anesthesiology
GA CN4FL
UT WOS:000358385800002
PM 25839182
ER
PT J
AU Basu, I
Kudela, P
Korzeniewska, A
Franaszczuk, PJ
Anderson, WS
AF Basu, Ishita
Kudela, Pawel
Korzeniewska, Anna
Franaszczuk, Piotr J.
Anderson, William S.
TI A study of the dynamics of seizure propagation across micro domains in
the vicinity of the seizure onset zone
SO JOURNAL OF NEURAL ENGINEERING
LA English
DT Article
DE micro seizure propagation; high gamma band; directed transfer function
ID HIGH-FREQUENCY OSCILLATIONS; DIRECTED TRANSFER-FUNCTION; TEMPORAL-LOBE
SEIZURES; HUMAN PARTIAL EPILEPSY; INTRACRANIAL EEG; EPILEPTOGENIC
NETWORKS; STATISTICAL ASSESSMENT; GRANGER CAUSALITY; INFORMATION-FLOW;
BRAIN STRUCTURES
AB Objective. The use of micro-electrode arrays to measure electrical activity from the surface of the brain is increasingly being investigated as a means to improve seizure onset zone (SOZ) localization. In this work, we used a multivariate autoregressive model to determine the evolution of seizure dynamics in the 70-110 Hz high frequency band across micro-domains sampled by such micro-electrode arrays. We showed that a directed transfer function (DTF) can be used to estimate the flow of seizure activity in a set of simulated micro-electrode data with known propagation pattern. Approach. We used seven complex partial seizures recorded from four patients undergoing intracranial monitoring for surgical evaluation to reconstruct the seizure propagation pattern over sliding windows using a DTF measure. Main results. We showed that a DTF can be used to estimate the flow of seizure activity in a set of simulated micro-electrode data with a known propagation pattern. In general, depending on the location of the micro-electrode grid with respect to the clinical SOZ and the time from seizure onset, ictal propagation changed in directional characteristics over a 2-10 s time scale, with gross directionality limited to spatial dimensions of approximately 9 mm(2). It was also seen that the strongest seizure patterns in the high frequency band and their sources over such micro-domains are more stable over time and across seizures bordering the clinically determined SOZ than inside. Significance. This type of propagation analysis might in future provide an additional tool to epileptologists for characterizing epileptogenic tissue. This will potentially help narrowing down resection zones without compromising essential brain functions as well as provide important information about targeting anti-epileptic stimulation devices.
C1 [Basu, Ishita; Kudela, Pawel; Anderson, William S.] Johns Hopkins Univ, Dept Neurosurg, Baltimore, MD 21218 USA.
[Korzeniewska, Anna; Franaszczuk, Piotr J.] Johns Hopkins Univ, Dept Neurol, Baltimore, MD 21218 USA.
[Franaszczuk, Piotr J.] US Army Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD USA.
RP Basu, I (reprint author), Johns Hopkins Univ, Dept Neurosurg, Baltimore, MD 21218 USA.
EM ibjuslc@gmail.com
RI Franaszczuk, Piotr/B-6532-2008
OI Franaszczuk, Piotr/0000-0002-5166-4224
FU NIH [K08NS066099]
FX The authors would like to thank the epilepsy research team including Dr
Nathan Crone, Dr Angela Wabulya, Dr Sarah Kelly and Dr Elizabeth Felton
as well as the EMU technicians Karen and Viktor at Johns Hopkins
Hospital for their immense help setting up the micro-electrode
connections during electrode hookup. This work was supported by NIH
K08NS066099. The support for modeling part came from ARO
W911NF-12-1-0418.
NR 49
TC 3
Z9 3
U1 1
U2 15
PU IOP PUBLISHING LTD
PI BRISTOL
PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
SN 1741-2560
EI 1741-2552
J9 J NEURAL ENG
JI J. Neural Eng.
PD AUG
PY 2015
VL 12
IS 4
AR 046016
DI 10.1088/1741-2560/12/4/046016
PG 17
WC Engineering, Biomedical; Neurosciences
SC Engineering; Neurosciences & Neurology
GA CN1KM
UT WOS:000358178900018
PM 26061006
ER
PT J
AU Marathe, AR
Taylor, DM
AF Marathe, A. R.
Taylor, D. M.
TI The impact of command signal power distribution, processing delays, and
speed scaling on neurally-controlled devices
SO JOURNAL OF NEURAL ENGINEERING
LA English
DT Article
DE brain-machine interface; brain-computer interface; closed-loop control;
neuroprosthesis; visually-guided reaching
ID BRAIN-COMPUTER INTERFACE; CONTINUOUS VISUAL FEEDBACK; DECODING
ALGORITHMS; MACHINE INTERFACES; REACHING MOVEMENTS; MOTOR CORTEX;
HUMANS; ADAPTATION; HAND; VARIABILITY
AB Objective. Decoding algorithms for brain-machine interfacing (BMI) are typically only optimized to reduce the magnitude of decoding errors. Our goal was to systematically quantify how four characteristics of BMI command signals impact closed-loop performance: (1) error magnitude, (2) distribution of different frequency components in the decoding errors, (3) processing delays, and (4) command gain. Approach. To systematically evaluate these different command features and their interactions, we used a closed-loop BMI simulator where human subjects used their own wrist movements to command the motion of a cursor to targets on a computer screen. Random noise with three different power distributions and four different relative magnitudes was added to the ongoing cursor motion in real time to simulate imperfect decoding. These error characteristics were tested with four different visual feedback delays and two velocity gains. Main results. Participants had significantly more trouble correcting for errors with a larger proportion of low-frequency, slow-time-varying components than they did with jittery, higher-frequency errors, even when the error magnitudes were equivalent. When errors were present, a movement delay often increased the time needed to complete the movement by an order of magnitude more than the delay itself. Scaling down the overall speed of the velocity command can actually speed up target acquisition time when low-frequency errors and delays are present. Significance. This study is the first to systematically evaluate how the combination of these four key command signal features (including the relatively-unexplored error power distribution) and their interactions impact closed-loop performance independent of any specific decoding method. The equations we derive relating closed-loop movement performance to these command characteristics can provide guidance on how best to balance these different factors when designing BMI systems. The equations reported here also provide an efficient way to compare a diverse range of decoding options offline.
C1 [Marathe, A. R.; Taylor, D. M.] Cleveland Clin, Dept Neurosci, Cleveland, OH 44195 USA.
[Marathe, A. R.; Taylor, D. M.] Case Western Reserve Univ, Dept Biomed Engn, Cleveland, OH 44106 USA.
[Marathe, A. R.; Taylor, D. M.] Louis Stokes VA Med Ctr, Cleveland Funct Elect Stimulat FES Ctr Excellence, Cleveland, OH 44106 USA.
[Marathe, A. R.] US Army Res Lab, Human Res & Engn Directorate, Aberdeen Proving Ground, MD 21005 USA.
RP Taylor, DM (reprint author), Cleveland Clin, Dept Neurosci, Cleveland, OH 44195 USA.
EM dawn.taylor@case.edu
FU Department of Veterans Affairs merit review [B4195R]; National
Institutes of Health NINDS [R01NS058871]; Cleveland Clinic; Case Western
Reserve University
FX This project was supported by the Department of Veterans Affairs merit
review #B4195R, the National Institutes of Health NINDS R01NS058871, the
Cleveland Clinic, and Case Western Reserve University.
NR 30
TC 1
Z9 1
U1 2
U2 7
PU IOP PUBLISHING LTD
PI BRISTOL
PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
SN 1741-2560
EI 1741-2552
J9 J NEURAL ENG
JI J. Neural Eng.
PD AUG
PY 2015
VL 12
IS 4
AR 046031
DI 10.1088/1741-2560/12/4/046031
PG 12
WC Engineering, Biomedical; Neurosciences
SC Engineering; Neurosciences & Neurology
GA CN1KM
UT WOS:000358178900033
PM 26170261
ER
PT J
AU Soares, JW
Kirby, R
Doherty, LA
Meehan, A
Arcidiacono, S
AF Soares, Jason W.
Kirby, Romy
Doherty, Laurel A.
Meehan, Alexa
Arcidiacono, Steven
TI Immobilization and orientation-dependent activity of a naturally
occurring antimicrobial peptide
SO JOURNAL OF PEPTIDE SCIENCE
LA English
DT Article
DE antimicrobial; immobilized; peptide; activity
ID ANTIBACTERIAL SURFACES; ESCHERICHIA-COLI; CECROPIN P1; COATINGS;
ATTACHMENT; PREVENTION; RESISTANCE; EFFICACY; TITANIUM; GROWTH
AB A naturally occurring antimicrobial peptide, SMAP-29, was synthesized with an n-terminal or c-terminal cysteine, termed c_SMAP and SMAP_c, respectively, for site-directed immobilization to superparamagnetic beads. Immobilized SMAP orientation-dependent activity was probed against multiple bacteria of clinical interest including Acinetobacter baumannii, Pseudomonas aeruginosa, Bacillus anthracis sterne and Staphylococcus aureus. A kinetic microplate assay was employed to reveal both concentration and time-dependent activity for elucidation of minimum bactericidal concentration (MBC) and sub-lethal effects. Immobilized SMAP activity was equivalent or reduced compared with soluble SMAP_c and c_SMAP regardless of immobilization orientation, with only one exception. A comparison of immobilized SMAP_c and c_SMAP activity revealed a bacteria-specific potency dependent on immobilization orientation, which was contrary to that seen in solution, wherein SMAP_c was more potent against all bacteria than c_SMAP. Sub-MBC kinetic studies displayed the influence of peptide exposure to the cells with multiple bacteria exhibiting increased susceptibility and efficacy at lower concentrations upon extended exposure (i.e. MBC enhancement). For instances in which complete killing was not achieved, two predominant effects were evident: retardation of growth rate and an increased lag phase. Both effects, seen independently and concomitantly, indicate some degree of induced cellular damage that can serve as a predictor toward eventual cell death. SMAP_c immobilized on glass through standard silanization chemistry was also investigated to ascertain the influence of substrate on activity against select bacteria. Published 2015. This article is a U.S. Government work and is in the public domain in the USA.
C1 [Soares, Jason W.; Kirby, Romy; Doherty, Laurel A.; Meehan, Alexa; Arcidiacono, Steven] US Army Natick Soldier Res, Ctr Dev & Engn, Natick, MA 01760 USA.
RP Arcidiacono, S (reprint author), US Army Natick Soldier Res, Ctr Dev & Engn, Natick, MA 01760 USA.
EM steven.m.arcidiacono.civ@mail.mil
NR 61
TC 0
Z9 0
U1 8
U2 26
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1075-2617
EI 1099-1387
J9 J PEPT SCI
JI J. Pept. Sci.
PD AUG
PY 2015
VL 21
IS 8
BP 669
EP 679
DI 10.1002/psc.2787
PG 11
WC Biochemistry & Molecular Biology; Chemistry, Analytical
SC Biochemistry & Molecular Biology; Chemistry
GA CN4AD
UT WOS:000358369300007
PM 26018607
ER
PT J
AU Chen, SE
English, JB
Kennedy, AB
Leeman, ME
Masters, FJ
Pinelli, JP
Pang, WC
Rullan-Rodriguez, JA
Calvo, J
Briones, FA
AF Chen, Shen-En
English, J. Brandon
Kennedy, Andrew B.
Leeman, Mark E.
Masters, Forrest J.
Pinelli, Jean Paul
Pang, Weichiang
Rullan-Rodriguez, Jose A.
Calvo, Joseph
Briones, Ferdie A.
TI ASCE Hurricane Haiyan Disaster Investigation in the Philippines
SO JOURNAL OF PERFORMANCE OF CONSTRUCTED FACILITIES
LA English
DT Editorial Material
C1 [Chen, Shen-En; Calvo, Joseph] Univ N Carolina, Dept Civil & Environm Engn, Charlotte, NC 28223 USA.
[English, J. Brandon] Conestoga Rovers & Associates, Houston, TX 77040 USA.
[Kennedy, Andrew B.] Univ Notre Dame, Dept Civil & Environm Engn & Earth Sci, Notre Dame, IN 46556 USA.
[Leeman, Mark E.] Facil Engn Associates, Fairfax, VA 22033 USA.
[Masters, Forrest J.] Univ Florida, Dept Civil & Coastal Engn, Gainesville, FL 32611 USA.
[Pinelli, Jean Paul] Florida Inst Technol, Dept Civil Engn, Melbourne, FL 32901 USA.
[Pang, Weichiang] Clemson Univ, Glenn Dept Civil Engn, Clemson, SC 29634 USA.
[Rullan-Rodriguez, Jose A.] US Army Corps Engineers, Engn Res & Dev Ctr, Geotech & Struct Lab, Struct Mech Branch, Vicksburg, MS 39183 USA.
[Briones, Ferdie A.] Dept Publ Works & Highways, Quezon City, Philippines.
RP Chen, SE (reprint author), Univ N Carolina, Dept Civil & Environm Engn, Charlotte, NC 28223 USA.
EM schen12@uncc.edu; jenglish@craworld.com; Andrew.b.kennedy.117@nd.edu;
mark.leeman@feapc.com; masters@ce.ufl.edu; pinelli@fit.edu;
wpang@clemson.edu; jose.a.rullan-rodriguez@usace.army.mil;
jcalvo2@uncc.edu; briones.ferdie@dpwh.gov.ph
RI Kennedy, Andrew/E-4746-2011; Masters, Forrest/D-1287-2011;
OI Kennedy, Andrew/0000-0002-7254-1346; Masters,
Forrest/0000-0001-8203-9846; Pinelli, Jean-Paul/0000-0002-6663-9486
NR 2
TC 1
Z9 1
U1 2
U2 7
PU ASCE-AMER SOC CIVIL ENGINEERS
PI RESTON
PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA
SN 0887-3828
EI 1943-5509
J9 J PERFORM CONSTR FAC
JI J. Perform. Constr. Facil.
PD AUG
PY 2015
VL 29
IS 4
AR 02514003
DI 10.1061/(ASCE)CF.1943-5509.0000707
PG 5
WC Construction & Building Technology; Engineering, Civil
SC Construction & Building Technology; Engineering
GA CN1JW
UT WOS:000358176900033
ER
PT J
AU Hoemann, JM
Shull, JS
Salim, HH
Bewick, BT
Davidson, JS
AF Hoemann, John M.
Shull, Jonathan S.
Salim, Hani H.
Bewick, Bryan T.
Davidson, James S.
TI Performance of Partially Grouted, Minimally Reinforced CMU Cavity Walls
against Blast Demands. II: Performance under Impulse Loads
SO JOURNAL OF PERFORMANCE OF CONSTRUCTED FACILITIES
LA English
DT Article
DE Blast; Masonry; Resistance; Ultimate strength; Unified facilities
criteria; Walls
AB This paper presents the results of full-scale blast load testing of partially grouted single-wythe and multiwythe insulated masonry walls. Three design sections were evaluated, as follows: (1) a 150-mm (6-in.) standard block masonry wall reinforced with 10-mm (No. 3) rebar at 80-cm (32-in.) maximum spacing, (2) a 200-mm (8-in.) standard block masonry wall reinforced with 13-mm (No. 4) rebar at 122-cm (48-in.) maximum spacing, and (3) a cavity wall consisting of 200-mm (8-in.) standard reinforced concrete masonry unit (CMU) wythe plus a 102-cm (4-in.) clay facing brick veneer with 52-mm (2-in.) thick extruded polystyrene rigid board insulation and a 25-mm (1-in.) air gap between the structural wythe and the veneer. Each test panel was 285 cm (112 in.), seven blocks, in width x 345 cm (136 in.), 17 courses, in height. Only the cells containing reinforcement were grouted. Three blast load experiments were conducted; each experiment tested one each of the three test panel designs. The loading varied significantly between each of the three experiments. Dynamic displacement at several locations through the height (quarter points) of each panel was recorded. The reflected pressures, free field pressures, and internal pressures were recorded at several locations. Interior and exterior videography was also used to record the response. A detailed posttest forensic evaluation was conducted to determine predominant failure mechanisms. The measured transient deflection responses were then compared to analytical responses calculated using the static resistance functions generated from the test results presented in the companion paper as well as by typical blast design methodologies. The comparisons demonstrated that the design resistances used in blast analysis single degree of freedom methodology are conservative. However, the blast testing demonstrated that potentially dangerous modes of localized failure between the grouted cells can occur at scaled distances that are significantly greater than scaled distances that would be assumed to cause breaching. (C) 2014 American Society of Civil Engineers.
C1 [Hoemann, John M.] US Army Engn Res & Dev Ctr, CEERD GS V, Vicksburg, MS 39180 USA.
[Hoemann, John M.] Air Force Res Lab, Working Support, Panama City, FL 32401 USA.
[Shull, Jonathan S.] Black & Veatch Consulting Engineers, Fed Serv Div, Webb City, MO 64870 USA.
[Salim, Hani H.] Univ Missouri, Civil Engn, Columbia, MO 65211 USA.
[Bewick, Bryan T.] Protect Engn Consultants, Austin, TX 78737 USA.
[Davidson, James S.] Auburn Univ, Dept Civil Engn, Harbert Engn Ctr 238, Auburn, AL 36849 USA.
RP Davidson, JS (reprint author), Auburn Univ, Dept Civil Engn, Harbert Engn Ctr 238, Auburn, AL 36849 USA.
EM john.m.hoemann@usace.army.mil; shulljs@bv.com; SalimH@missouri.edu;
bbewick@protection-consultants.com; Jim.Davidson@auburn.edu
FU Airbase Technologies Division, Engineering Mechanics Section of the Air
Force Research Laboratory (AFRL) at Tyndall Air Force Base, Florida;
NCMA Education and Research Foundation Grant
FX The experimental components of the research reported in this paper were
sponsored by the Airbase Technologies Division, Engineering Mechanics
Section of the Air Force Research Laboratory (AFRL) at Tyndall Air Force
Base, Florida. The AFRL program manager during the experimental phase of
the research reported in this paper was Dr. Robert Dinan. Experimental
samples were provided through a Cooperative Research and Development
Agreement (CRADA) with the Portland Cement Association (PCA; CRADA No.
05-119-ML-01). Mr. Dennis Graber from the National Concrete Masonry
Association (NCMA) and Mr. Greg Borchelt from the Brick Industry
Association (BIA) assisted throughout the planning and execution of the
research reported in this paper. Static experiments were conducted at
the National Center of Explosive Research and Design (NCERD), University
of Missouri-Columbia, under the supervision of Dr. Hani Salim and Mr.
Aaron Saucier. Masonry material tests were conducted by NCMA. Employees
of Black and Veatch, and Applied Research Associates, contributed to the
execution of the research reported in this paper. Auburn University
researchers in the Department of Civil Engineering, under the guidance
of Dr. James Davidson, provided pretest support of the research reported
in this paper, as well as posttest analysis of the experimental data,
which was partially sponsored through an NCMA Education and Research
Foundation Grant. In addition the writers thank the Geotechnical and
Structural Laboratory of the U.S. Army Engineer Research and Development
Center for efforts in revising this paper. Citation of manufacturers or
trade names does not constitute an official endorsement or approval of
the use thereof. The U.S. government is authorized to reproduce and
distribute reprints for government purposes not-withstanding any
copyright notation in this paper.
NR 25
TC 1
Z9 1
U1 0
U2 2
PU ASCE-AMER SOC CIVIL ENGINEERS
PI RESTON
PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA
SN 0887-3828
EI 1943-5509
J9 J PERFORM CONSTR FAC
JI J. Perform. Constr. Facil.
PD AUG
PY 2015
VL 29
IS 4
AR 04014114
DI 10.1061/(ASCE)CF.1943-5509.0000509
PG 15
WC Construction & Building Technology; Engineering, Civil
SC Construction & Building Technology; Engineering
GA CN1JW
UT WOS:000358176900004
ER
PT J
AU McCoy, BC
Seracino, R
Leming, ML
AF McCoy, Brad C.
Seracino, Rudolf
Leming, Michael L.
TI Modified Layered-Sectional Analysis for Forensic Investigation
SO JOURNAL OF PERFORMANCE OF CONSTRUCTED FACILITIES
LA English
DT Article
DE Layered-sectional analysis; Sustainability; Damage assessment; Dynamic
elastic (Young's) modulus; Resonant frequency
ID NONLINEAR-ANALYSIS; ELASTIC PROPERTIES; FIRE CONDITIONS; CONCRETE;
FRAMES; DAMAGE; MODEL
AB This paper describes a modification to the layered-sectional analysis approach, which provides the engineer with a tool to assess structural behavior of concrete beams with localized damage, a problem not well suited to classical, closed-form solutions. The modified layered-sectional analysis (MLSA) framework is applied to a forensic investigation case study in which two prestressed double-tee beams are exposed to a short duration, intense fire in a parking structure. The results of the MLSA are within 1% of the case study load test, which indicates that the MLSA could be a useful, computationally efficient tool for the investigating engineer to predict the postfire serviceability and strength of damaged beams, and potentially eliminate the need for expensive load testing. A short parametric study is included for the research engineer interested in the MLSA for predicting the postdamage behavior of non-standard materials such as enhanced sustainability concrete (ESC). (C) 2014 American Society of Civil Engineers.
C1 [McCoy, Brad C.] US Mil Acad, Dept Civil & Mech Engn, West Point, NY 10996 USA.
[Seracino, Rudolf] N Carolina State Univ, Struct Engn, Dept Civil Construct & Environm Engn, Raleigh, NC 27695 USA.
[Leming, Michael L.] N Carolina State Univ, Construct Engn & Management, Dept Civil Construct & Environm Engn, Raleigh, NC 27607 USA.
RP McCoy, BC (reprint author), US Mil Acad, Dept Civil & Mech Engn, 218 Mahan Hall,BLDG 752, West Point, NY 10996 USA.
EM brad.mccoy@usma.edu
NR 24
TC 0
Z9 0
U1 0
U2 4
PU ASCE-AMER SOC CIVIL ENGINEERS
PI RESTON
PA 1801 ALEXANDER BELL DR, RESTON, VA 20191-4400 USA
SN 0887-3828
EI 1943-5509
J9 J PERFORM CONSTR FAC
JI J. Perform. Constr. Facil.
PD AUG
PY 2015
VL 29
IS 4
AR 04014121
DI 10.1061/(ASCE)CF.1943-5509.0000583
PG 11
WC Construction & Building Technology; Engineering, Civil
SC Construction & Building Technology; Engineering
GA CN1JW
UT WOS:000358176900013
ER
PT J
AU Andersen, RC
Schmidt, AH
Fitzgerald, BT
Tintle, SM
Helgeson, MD
Lehman, RA
Davila, JN
Potter, BK
Burns, TC
Swiontkowski, MF
Ficke, JR
AF Andersen, Romney C.
Schmidt, Andrew H.
Fitzgerald, Brian T.
Tintle, Scott M.
Helgeson, Melvin D.
Lehman, Ronald A.
Davila, Jeffrey N.
Potter, Benjamin K.
Burns, Travis C.
Swiontkowski, Marc F.
Ficke, James R.
TI Extremity War Injuries IX: Reducing Disability Within the Military
SO JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS
LA English
DT Article
ID PULSED ULTRASOUND THERAPY; POSTTRAUMATIC ARTHRITIS; SHAFT FRACTURES;
INFECTIOUS COMPLICATIONS; INTRAARTICULAR FRACTURE;
ELECTRICAL-STIMULATION; FUNCTIONAL OUTCOMES; ARTICULAR FRACTURES;
EXTERNAL FIXATION; FEMUR FRACTURES
AB Extremity War Injury Symposium IX focused on reducing disability within the military, centering on cartilage defects, amputations, and spinal cord injury. Many areas of upper and lower extremity trauma and disability were discussed, including segmental nerve injuries, upper extremity allotransplantation, and the importance of patient-reported functional outcomes compared with the traditionally reported measures. Strategic planning addressed progression toward clinical solutions by setting clear objectives and goals and outlining pathways to address the "translation gap" that often prevents bridging of basic science to clinical application.
C1 [Andersen, Romney C.; Tintle, Scott M.; Helgeson, Melvin D.; Davila, Jeffrey N.; Potter, Benjamin K.] Walter Reed Natl Mil Med Ctr, Dept Orthopaed Surg, Bethesda, MD 20889 USA.
[Schmidt, Andrew H.] Hennepin Cty Med Ctr, Minneapolis, MN 55415 USA.
[Fitzgerald, Brian T.] Naval Med Ctr San Diego, San Diego, CA USA.
[Lehman, Ronald A.] Washington Univ, Sch Med, Dept Orthopaed Surg, St Louis, MO USA.
[Burns, Travis C.] Brooke Army Med Ctr, Houston, TX USA.
[Swiontkowski, Marc F.] Univ Minnesota, Minneapolis, MN USA.
[Ficke, James R.] Johns Hopkins Univ Hosp, Baltimore, MD USA.
RP Andersen, RC (reprint author), Walter Reed Natl Mil Med Ctr, Dept Orthopaed Surg, Bethesda, MD 20889 USA.
OI Potter, MD, Benjamin K./0000-0002-8771-0317
FU Acumed; Bone Support AB; St. Jude Medical; Medtronic; AOSpine; Centinel
Spine
FX Dr. Andersen or an immediate family member serves as a board member,
owner, officer, or committee member of the American Association of
Orthopaedic Surgeons; the Orthopaedic Trauma Association, Military
Committee; PRORP Steering Committee; and the Walter Reed Bethesda
Orthopaedic Alumni Association. Dr. Schmidt or an immediate family
member serves as a paid consultant to Acumed, Bone Support AB, and St.
Jude Medical; serves as an unpaid consultant to Twin Star Medical and
Conventus Orthopaedics; has stock or stock options held in Conventus
Orthopaedics, Epien, Epix VAN, International Spine and Orthopaedic
Institute, and Twin Star Medical; and serves as a board member, owner,
officer, or committee member of the Orthopaedic Trauma Association. Dr.
Lehman or an immediate family member is a member of a speakers' bureau
or has made paid presentations on behalf of DePuy, Medtronic, and
Stryker; serves as a paid consultant to Medtronic; has received research
or institutional support from AOSpine and Centinel Spine; and serves as
a board member, owner, officer, or committee member of AOSpine, the
Cervical Spine Research Society, the North American Spine Society, and
the Scoliosis Research Society. Dr. Potter serves as a board member,
owner, officer, or committee member of the American Association of
Orthopaedic Surgeons and the Society of Military Orthopaedic Surgeons.
Dr. Swiontkowski or an immediate family member serves as a paid
consultant to Eli Lilly and serves as a board member, owner, officer, or
committee member of the American Orthopaedic Association and the Mid
America Orthopaedic Association. Dr. Ficke serves as a board member,
owner, officer, or committee member of the American Orthopaedic
Association. None of the following authors or any immediate family
member has received anything of value from or has stock or stock options
held in a commercial company or institution related directly or
indirectly to the subject of this article: Dr. Fitzgerald, Dr. Tintle,
Dr. Helgeson, Dr. Davila, and Dr. Burns.
NR 69
TC 0
Z9 0
U1 2
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1067-151X
EI 1940-5480
J9 J AM ACAD ORTHOP SUR
JI J. Am. Acad. Orthop. Surg.
PD AUG
PY 2015
VL 23
IS 8
BP E13
EP E26
DI 10.5435/JAAOS-D-15-00205
PG 14
WC Orthopedics; Surgery
SC Orthopedics; Surgery
GA CN4RI
UT WOS:000358417500003
ER
PT J
AU Wieczorek, L
Krebs, SJ
Kalyanaraman, V
Whitney, S
Tovanabutra, S
Moscoso, CG
Sanders-Buell, E
Williams, C
Slike, B
Molnar, S
Dussupt, V
Alam, SM
Chenine, AL
Tong, T
Hill, EL
Liao, HX
Hoelscher, M
Maboko, L
Zolla-Pazner, S
Haynes, BF
Pensiero, M
McCutchan, F
Malek-Salehi, S
Cheng, RH
Robb, ML
VanCott, T
Michael, NL
Marovich, MA
Alving, CR
Matyas, GR
Rao, M
Polonis, VR
AF Wieczorek, Lindsay
Krebs, Shelly J.
Kalyanaraman, Vaniambadi
Whitney, Stephen
Tovanabutra, Sodsai
Moscoso, Carlos G.
Sanders-Buell, Eric
Williams, Constance
Slike, Bonnie
Molnar, Sebastian
Dussupt, Vincent
Alam, S. Munir
Chenine, Agnes-Laurence
Tong, Tina
Hill, Edgar L.
Liao, Hua-Xin
Hoelscher, Michael
Maboko, Leonard
Zolla-Pazner, Susan
Haynes, Barton F.
Pensiero, Michael
McCutchan, Francine
Malek-Salehi, Shawyon
Cheng, R. Holland
Robb, Merlin L.
VanCott, Thomas
Michael, Nelson L.
Marovich, Mary A.
Alving, Carl R.
Matyas, Gary R.
Rao, Mangala
Polonis, Victoria R.
TI Comparable Antigenicity and Immunogenicity of Oligomeric Forms of a
Novel, Acute HIV-1 Subtype C gp145 Envelope for Use in Preclinical and
Clinical Vaccine Research
SO JOURNAL OF VIROLOGY
LA English
DT Article
ID HUMAN-IMMUNODEFICIENCY-VIRUS; BROADLY NEUTRALIZING ANTIBODIES;
RECOMBINANT GLYCOPROTEIN-120 VACCINE; MONOCLONAL-ANTIBODIES;
NONNEUTRALIZING ANTIBODIES; IMMUNE-RESPONSES; EFFICACY TRIAL;
CONFORMATIONAL EPITOPE; DEPENDENT EPITOPE; GENETIC SUBTYPES
AB Eliciting broadly reactive functional antibodies remains a challenge in human immunodeficiency virus type 1 (HIV-1) vaccine development that is complicated by variations in envelope (Env) subtype and structure. The majority of new global HIV-1 infections are subtype C, and novel antigenic properties have been described for subtype C Env proteins. Thus, an HIV-1 subtype C Env protein (CO6980v0c22) from an infected person in the acute phase (Fiebig stage I/II) was developed as a research reagent and candidate immunogen. The gp145 envelope is a novel immunogen with a fully intact membrane-proximal external region (MPER), extended by a polylysine tail. Soluble gp145 was enriched for trimers that yielded the expected "fan blade" motifs when visualized by cryoelectron microscopy. CO6980v0c22 gp145 reacts with the 4E10, PG9, PG16, and VRC01 HIV-1 neutralizing monoclonal antibodies (MAbs), as well as the V1/V2-specific PGT121, 697, 2158, and 2297 MAbs. Different gp145 oligomers were tested for immunogenicity in rabbits, and purified dimers, trimers, and larger multimers elicited similar levels of cross-subtype binding and neutralizing antibodies to tier 1 and some tier 2 viruses. Immunized rabbit sera did not neutralize the highly resistant CO6980v0c22 pseudovirus but did inhibit the homologous infectious molecular clone in a peripheral blood mononuclear cell (PBMC) assay. This Env is currently in good manufacturing practice (GMP) production to be made available for use as a clinical research tool and further evaluation as a candidate vaccine.
IMPORTANCE
At present, the product pipeline for HIV vaccines is insufficient and is limited by inadequate capacity to produce large quantities of vaccine to standards required for human clinical trials. Such products are required to evaluate critical questions of vaccine formulation, route, dosing, and schedule, as well as to establish vaccine efficacy. The gp145 Env protein presented in this study forms physical trimers, binds to many of the well-characterized broad neutralizing MAbs that target conserved Env epitopes, and induce cross-subtype neutralizing antibodies as measured in both cell line and primary cell assays. This subtype C Env gp145 protein is currently undergoing good manufacturing practice production for use as a reagent for preclinical studies and for human clinical research. This product will serve as a reagent for comparative studies and may represent a next-generation candidate HIV immunogen.
C1 [Wieczorek, Lindsay; Krebs, Shelly J.; Tovanabutra, Sodsai; Sanders-Buell, Eric; Slike, Bonnie; Molnar, Sebastian; Dussupt, Vincent; Chenine, Agnes-Laurence; McCutchan, Francine; Robb, Merlin L.; Michael, Nelson L.; Marovich, Mary A.; Alving, Carl R.; Matyas, Gary R.; Rao, Mangala; Polonis, Victoria R.] Mil HIV Res Program, Bethesda, MD 20817 USA.
[Wieczorek, Lindsay; Krebs, Shelly J.; Tovanabutra, Sodsai; Sanders-Buell, Eric; Slike, Bonnie; Molnar, Sebastian; Dussupt, Vincent; Chenine, Agnes-Laurence; McCutchan, Francine; Robb, Merlin L.] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA.
[Kalyanaraman, Vaniambadi; Whitney, Stephen; VanCott, Thomas] Adv Biosci Labs Inc, Rockville, MD USA.
[Wieczorek, Lindsay; Moscoso, Carlos G.; Malek-Salehi, Shawyon; Cheng, R. Holland] Univ Calif Davis, Davis, CA 95616 USA.
[Williams, Constance; Zolla-Pazner, Susan] NYU, Sch Med, New York, NY USA.
[Williams, Constance; Zolla-Pazner, Susan] Vet Affairs Med Ctr, New York, NY USA.
[Alam, S. Munir; Liao, Hua-Xin; Haynes, Barton F.] Duke Univ, Durham, NC USA.
[Tong, Tina; Hill, Edgar L.] Henry M Jackson Fdn Adv Mil Med, HJF DAIDS, Bethesda, MD USA.
[Pensiero, Michael; Marovich, Mary A.] NIH, Div Aids, Bethesda, MD 20892 USA.
[Hoelscher, Michael] Klinikum Univ Munich, Dept Infect Dis & Trop Med, Munich, Germany.
[Hoelscher, Michael] German Ctr Infect Res DZIF, Munich, Germany.
[Maboko, Leonard] Mbeya Med Res Ctr, Natl Inst Med Res, Mbeya, Tanzania.
[Michael, Nelson L.; Alving, Carl R.; Matyas, Gary R.; Rao, Mangala; Polonis, Victoria R.] Walter Reed Army Inst Res, Silver Spring, MD USA.
RP Polonis, VR (reprint author), Mil HIV Res Program, Bethesda, MD 20817 USA.
EM vpolonis@hivresearch.org
RI Hoelscher, Michael/D-3436-2012
FU Henry M. Jackson Foundation for the Advancement of Military Medicine,
Inc. [W81XWH-11-2-0174]; U.S. Department of Defense (DOD) (U.S. Army
Medical Research and Materiel Command) [W81XWH-11-2-0174]; Division of
AIDS, National Institute for Allergy and Infectious Diseases, NIH;
National Institute of Allergy and Infectious Diseases, NIH, Department
of Health and Human Services [HHSN272200800014C]; NIH [HL59725]; Fisher
BioService, Inc. [FBS-0022C-06]; Department of Veterans Affairs
FX This work was supported by a cooperative agreement (W81XWH-11-2-0174)
between the Henry M. Jackson Foundation for the Advancement of Military
Medicine, Inc., and the U.S. Department of Defense (DOD) (U.S. Army
Medical Research and Materiel Command), working together with the
Division of AIDS, National Institute for Allergy and Infectious
Diseases, NIH. This project has also been funded in part with federal
funds from the National Institute of Allergy and Infectious Diseases,
NIH, Department of Health and Human Services, under contract
HHSN272200800014C. Additional support was provided by NIH grant HL59725,
a contract (FBS-0022C-06) with Fisher BioService, Inc., and funds from
the Department of Veterans Affairs. The views expressed here are our
private opinions and are not to be considered official or to reflect the
views of the U.S. Army, the U.S. Department of Defense, or the U.S.
Government. The use of trade names is for identification only and does
not imply endorsement by the U.S. Government.
NR 97
TC 8
Z9 8
U1 0
U2 10
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0022-538X
EI 1098-5514
J9 J VIROL
JI J. Virol.
PD AUG
PY 2015
VL 89
IS 15
BP 7478
EP 7493
DI 10.1128/JVI.00412-15
PG 16
WC Virology
SC Virology
GA CN2UP
UT WOS:000358277800005
PM 25972551
ER
PT J
AU Johnson, S
Eller, M
Teigler, JE
Maloveste, SM
Schultz, BT
Soghoian, DZ
Lu, R
Oster, AF
Chenine, AL
Alter, G
Dittmer, U
Marovich, M
Robb, ML
Michael, NL
Bolton, D
Streeck, H
AF Johnson, Susan
Eller, Michael
Teigler, Jeffrey E.
Maloveste, Sebastien M.
Schultz, Bruce T.
Soghoian, Damien Z.
Lu, Richard
Oster, Alexander F.
Chenine, Agnes-Laurence
Alter, Galit
Dittmer, Ulf
Marovich, Mary
Robb, Merlin L.
Michael, Nelson L.
Bolton, Diane
Streeck, Hendrik
TI Cooperativity of HIV-Specific Cytolytic CD4 T Cells and CD8 T Cells in
Control of HIV Viremia
SO JOURNAL OF VIROLOGY
LA English
DT Article
ID IMMUNODEFICIENCY-VIRUS; TRANSCRIPTION FACTOR; RESPONSES; EXPRESSION;
EOMESODERMIN; INFECTION; EFFECTOR; CD57; VIVO; DIFFERENTIATION
AB CD4(+) T cells play a pivotal role in the control of chronic viral infections. Recently, nontraditional CD4(+) T cell functions beyond helper effects have been described, and a role for cytolytic CD4(+) T cells in the control of HIV infection has been suggested. We define here the transcriptional, phenotypic, and functional profiles of HIV-specific cytolytic CD4(+) T cells. Fluidigm BioMark and multiparameter flow cytometric analysis of HIV-specific cytolytic CD4(+) T cells revealed a distinct transcriptional signature compared to Th1 CD4(+) cells but shared similar features with HIV-specific cytolytic CD8(+) T cells. Furthermore, HIV-specific cytolytic CD4(+) T cells showed comparable killing activity relative to HIV-specific CD8(+) T cells and worked cooperatively in the elimination of virally infected cells. Interestingly, we found that cytolytic CD4(+) T cells emerge early during acute HIV infection and tightly follow acute viral load trajectory. This emergence was associated to the early viral set point, suggesting an involvement in early control, in spite of CD4 T cell susceptibility to HIV infection. Our data suggest cytolytic CD4(+) T cells as an independent subset distinct from Th1 cells that show combined activity with CD8(+) T cells in the long-term control of HIV infection.
IMPORTANCE
The ability of the immune system to control chronic HIV infection is of critical interest to both vaccine design and therapeutic approaches. Much research has focused on the effect of the ability of CD8(+) T cells to control the virus, while CD4(+) T cells have been overlooked as effectors in HIV control due to the fact that they are preferentially infected. We show here that a subset of HIV-specific CD4(+) T cells cooperate in the cytolytic control of HIV replication. Moreover, these cells represent a distinct subset of CD4(+) T cells showing significant transcriptional and phenotypic differences compared to HIV-specific Th1 cells but with similarities to CD8+ T cells. These findings are important for our understanding of HIV immunopathology.
C1 [Johnson, Susan; Eller, Michael; Teigler, Jeffrey E.; Maloveste, Sebastien M.; Schultz, Bruce T.; Lu, Richard; Oster, Alexander F.; Chenine, Agnes-Laurence; Marovich, Mary; Robb, Merlin L.; Michael, Nelson L.; Bolton, Diane; Streeck, Hendrik] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA.
[Johnson, Susan; Eller, Michael; Teigler, Jeffrey E.; Maloveste, Sebastien M.; Schultz, Bruce T.; Lu, Richard; Oster, Alexander F.; Chenine, Agnes-Laurence; Marovich, Mary; Robb, Merlin L.; Michael, Nelson L.; Bolton, Diane; Streeck, Hendrik] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA.
[Soghoian, Damien Z.; Alter, Galit] MIT, Ragon Inst MGH, Boston, MA USA.
[Soghoian, Damien Z.; Alter, Galit] Harvard Univ, Boston, MA 02115 USA.
[Dittmer, Ulf] Univ Duisburg Essen, Inst Virol, Univ Hosp Essen, Essen, Germany.
[Streeck, Hendrik] Univ Duisburg Essen, Univ Hosp Essen, Inst Med Biol, Essen, Germany.
RP Streeck, H (reprint author), Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD 20910 USA.
EM hendrik.streeck@uk-essen.de
FU U.S. National Institutes of Health (NIH) [R01 AI091450-01, R01
AI094602-01]; Henry M. Jackson Foundation for the Advancement of
Military Medicine, Inc. [W81XWH-11-2-0174]; U.S. Department of Defense
FX This study was funded by the U.S. National Institutes of Health (NIH;
R01 AI091450-01 and R01 AI094602-01) and a cooperative agreement
(W81XWH-11-2-0174) between the Henry M. Jackson Foundation for the
Advancement of Military Medicine, Inc., and the U.S. Department of
Defense. The following reagents were obtained through the NIH AIDS
Reagent Program, Division of AIDS, NIAID, NIH: nevirapine; human rIL-2
from Maurice Gately, Hoffmann-La Roche, Inc.; and pNL4-3 from Malcolm
Martin.
NR 38
TC 14
Z9 14
U1 1
U2 5
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0022-538X
EI 1098-5514
J9 J VIROL
JI J. Virol.
PD AUG
PY 2015
VL 89
IS 15
BP 7494
EP 7505
DI 10.1128/JVI.00438-15
PG 12
WC Virology
SC Virology
GA CN2UP
UT WOS:000358277800006
PM 25972560
ER
PT J
AU Lauck, M
Alkhovsky, SV
Bao, YM
Bailey, AL
Shevtsova, ZV
Shchetinin, AM
Vishnevskaya, TV
Lackemeyer, MG
Postnikova, E
Mazur, S
Wada, JR
Radoshitzky, SR
Friedrich, TC
Lapin, BA
Deriabin, PG
Jahrling, PB
Goldberg, TL
O'Connor, DH
Kuhn, JH
AF Lauck, Michael
Alkhovsky, Sergey V.
Bao, Yiming
Bailey, Adam L.
Shevtsova, Zinaida V.
Shchetinin, Alexey M.
Vishnevskaya, Tatyana V.
Lackemeyer, Matthew G.
Postnikova, Elena
Mazur, Steven
Wada, Jiro
Radoshitzky, Sheli R.
Friedrich, Thomas C.
Lapin, Boris A.
Deriabin, Petr G.
Jahrling, Peter B.
Goldberg, Tony L.
O'Connor, David H.
Kuhn, Jens H.
TI Historical Outbreaks of Simian Hemorrhagic Fever in Captive Macaques
Were Caused by Distinct Arteriviruses
SO JOURNAL OF VIROLOGY
LA English
DT Article
ID NONHUMAN-PRIMATES; VIRUS ISOLATE; ALIGNMENT; MONKEYS; STRAINS; DISEASE;
TOOL; SHF
AB Simian hemorrhagic fever (SHF) is lethal for macaques. Based on clinical presentation and serological diagnosis, all reported SHF outbreaks were thought to be caused by different strains of the same virus, simian hemorrhagic fever virus (SHFV; Arteriviridae). Here we show that the SHF outbreaks in Sukhumi in 1964 and in Alamogordo in 1989 were caused not by SHFV but by two novel divergent arteriviruses. Our results indicate that multiple divergent simian arteriviruses can cause SHF.
C1 [Lauck, Michael; Bailey, Adam L.; Friedrich, Thomas C.; Goldberg, Tony L.; O'Connor, David H.] Univ Wisconsin, Madison, WI USA.
[Alkhovsky, Sergey V.; Shchetinin, Alexey M.; Vishnevskaya, Tatyana V.; Deriabin, Petr G.] Minist Hlth Russian Federat, NF Gamaleya Fed Res Ctr Epidemiol & Microbiol, DI Ivanovsky Inst Virol, Moscow, Russia.
[Bao, Yiming] NIH, Informat Engn Branch, Natl Ctr Biotechnol Informat, Natl Lib Med, Bethesda, MD 20892 USA.
[Shevtsova, Zinaida V.] Abkhazian Acad Sci, Sci Res Inst Expt Pathol & Therapy, Sukhumi, Rep of Georgia.
[Lackemeyer, Matthew G.; Postnikova, Elena; Mazur, Steven; Wada, Jiro; Jahrling, Peter B.; Kuhn, Jens H.] NIAID, Integrated Res Facil Ft Detrick, NIH, Frederick, MD 21702 USA.
[Radoshitzky, Sheli R.] US Army Med Res Inst Infect Dis, Frederick, MD USA.
[Lapin, Boris A.] Russian Acad Med Sci, Sci Res Inst Med Primatol, Soci, Russia.
RP Kuhn, JH (reprint author), NIAID, Integrated Res Facil Ft Detrick, NIH, Frederick, MD 21702 USA.
EM kuhnjens@mail.nih.gov
OI Postnikova, Elena/0000-0002-0275-2148; Shchetinin,
Alexey/0000-0003-1842-3899; Vishnevskaya, Tatyana/0000-0002-6963-8681;
Friedrich, Thomas/0000-0001-9831-6895; Lauck,
Michael/0000-0003-2813-3705
FU Battelle Memorial Institute; U.S. National Institute of Allergy and
Infectious Diseases [HHSN272200700016I]; NIH, NIH-National Science
Foundation Ecology of Infectious Disease program [TW009237, R01
AI077376]; Office of Research Infrastructure Programs grant
[P51OD011106]; Intramural Research Program of the NIH, National Library
of Medicine
FX The content of this publication does not necessarily reflect the views
or policies of the U.S. Department of the Army, the U.S. Department of
Defense, the U.S. Department of Health and Human Services, or the
institutions and companies with which we are affiliated. This work was
funded in part through the Battelle Memorial Institute's prime contract
with the U.S. National Institute of Allergy and Infectious Diseases
under contract HHSN272200700016I. The subcontractors to Battelle
Memorial Institute who performed this work are E.P. and J.H.K, employees
of Tunnell Government Services, Inc.; M.G.L., an employee of Lovelace
Respiratory Research Institute; and S.M., an employee of MRIGlobal. This
work was also funded in part by NIH grant TW009237 as part of the joint
NIH-National Science Foundation Ecology of Infectious Disease program,
grant R01 AI077376, and by Office of Research Infrastructure Programs
grant P51OD011106. This research was also supported in part by the
Intramural Research Program of the NIH, National Library of Medicine
(Y.B.).
NR 45
TC 6
Z9 6
U1 0
U2 3
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0022-538X
EI 1098-5514
J9 J VIROL
JI J. Virol.
PD AUG
PY 2015
VL 89
IS 15
BP 8082
EP 8087
DI 10.1128/JVI.01046-15
PG 6
WC Virology
SC Virology
GA CN2UP
UT WOS:000358277800052
PM 25972539
ER
PT J
AU Clark, DV
Kibuuka, H
Millard, M
Wakabi, S
Lukwago, L
Taylor, A
Eller, MA
Eller, LA
Michael, NL
Honko, AN
Olinger, GG
Schoepp, RJ
Hepburn, MJ
Hensley, LE
Robb, ML
AF Clark, Danielle V.
Kibuuka, Hannah
Millard, Monica
Wakabi, Salim
Lukwago, Luswa
Taylor, Alison
Eller, Michael A.
Eller, Leigh Anne
Michael, Nelson L.
Honko, Anna N.
Olinger, Gene G., Jr.
Schoepp, Randal J.
Hepburn, Matthew J.
Hensley, Lisa E.
Robb, Merlin L.
TI Long-term sequelae after Ebola virus disease in Bundibugyo, Uganda: a
retrospective cohort study
SO LANCET INFECTIOUS DISEASES
LA English
DT Article
ID HEMORRHAGIC-FEVER; LASSA FEVER; CHIKUNGUNYA; INFECTION; EPIDEMIC;
KIKWIT; CONGO; SURVIVORS
AB Background The limited data available for long-term Ebola virus disease health outcomes suggest that sequelae persist for longer than 1 year after infection. The magnitude of the present outbreak in west Africa necessitates a more complete understanding of the health effects and future medical needs of these patients.
Methods We invited adult survivors of the 2007 Bundibugyo Ebola virus outbreak in Uganda and their contacts to take part in an observational study roughly 29 months after the outbreak. We collected information about health status, functional limitations, and demographics. We collected blood samples for clinical chemistry, haematology, and filovirus antibodies using ELISA. Analyses were restricted to probable and confirmed survivors and their seronegative contacts.
Findings We recruited 70 survivors of the 2007 Bundibugyo Ebola virus and 223 contacts. We did analyses for 49 probable and confirmed survivors and 157 seronegative contacts. Survivors of the Bundibugyo Ebola virus were at significantly increased risk of ocular deficits (retro-orbital pain [RR 4.3, 95% CI 1.9-9.6; p<0.0001], blurred vision [1.9, 1.1-3.2; p=0.018]), hearing loss (2.3, 1.2-4.5; p=0.010), difficulty swallowing (2.1, 1.1-3.9; p=0.017), difficulty sleeping (1.9, 1.3-2.8; p=0.001), arthralgias (2.0, 1.1-3.6; p=0.020), and various constitutional symptoms controlling for age and sex. Chronic health problems (prevalence ratio [PR] 2.1, 95% CI 1.2-3.6; p=0.008) and limitations due to memory loss or confusion (PR 5.8, 1.5-22.4; p=0.010) were also reported more frequently by survivors of Bundibugyo Ebola virus.
Interpretation Long-term sequelae persist for more than 2 years after Ebola virus disease. Definition of health consequences related to Ebola virus disease could improve patient care for survivors and contribute to understanding of disease pathogenesis.
C1 [Clark, Danielle V.; Michael, Nelson L.] Walter Reed Army Inst Res, Silver Spring, MD USA.
[Clark, Danielle V.] Naval Med Res Ctr, Biol Def Res Directorate, Ft Detrick, MD 21702 USA.
[Kibuuka, Hannah; Millard, Monica; Wakabi, Salim; Taylor, Alison] Makerere Univ, Walter Reed Project, Kampala, Uganda.
[Lukwago, Luswa] Minist Hlth, Kampala, Uganda.
[Eller, Michael A.; Eller, Leigh Anne; Michael, Nelson L.; Robb, Merlin L.] US Mil, HIV Res Program, Bethesda, MD USA.
[Honko, Anna N.; Olinger, Gene G., Jr.; Hensley, Lisa E.] US Army, Med Res Inst Infect Dis, Div Virol, Ft Detrick, MD 21702 USA.
[Schoepp, Randal J.] US Army, Med Res Inst Infect Dis, Diagnost Syst Div, Ft Detrick, MD 21702 USA.
[Hepburn, Matthew J.] US Army, Med Res Inst Infect Dis, Div Med, Ft Detrick, MD 21702 USA.
[Honko, Anna N.; Olinger, Gene G., Jr.; Hensley, Lisa E.] NIAID, Integrated Res Facil, NIH, Ft Detrick, MD USA.
RP Clark, DV (reprint author), Naval Med Res Ctr, Biol Def Res Directorate, Ft Detrick, MD 21702 USA.
EM dclark@aceso-sepsis.org
OI Honko, Anna/0000-0001-9165-148X
FU Chemical Biological Technologies Directorate, Defense Threat Reduction
Agency
FX Chemical Biological Technologies Directorate, Defense Threat Reduction
Agency.
NR 25
TC 43
Z9 43
U1 2
U2 14
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1473-3099
EI 1474-4457
J9 LANCET INFECT DIS
JI Lancet Infect. Dis.
PD AUG
PY 2015
VL 15
IS 8
BP 905
EP 912
DI 10.1016/S1473-3099(15)70152-0
PG 8
WC Infectious Diseases
SC Infectious Diseases
GA CN1LW
UT WOS:000358182500029
PM 25910637
ER
PT J
AU Ahmad, FI
Gerecci, D
Gonzalez, JD
Peck, JJ
Wax, MK
AF Ahmad, Faisal I.
Gerecci, Deniz
Gonzalez, Javier D.
Peck, Jessica J.
Wax, Mark K.
TI The role of postoperative hematoma on free flap compromise
SO LARYNGOSCOPE
LA English
DT Article
DE Free tissue transfer; microvascular; hematoma; flap compromise
ID MICROVASCULAR FREE FLAPS; FREE TISSUE TRANSFER; VENOUS THROMBOEMBOLISM;
CANCER RESECTION; NECK-SURGERY; HEAD; RECONSTRUCTION; OTOLARYNGOLOGY;
COMPLICATIONS; EXPERIENCE
AB Objectives/HypothesisHematomas may develop in the postoperative setting after free tissue transfer. When hematomas occur, they can exert pressure on surrounding tissues. Their effect on the vascular pedicle of a free flap is unknown. We describe our incidence of hematoma in free flaps and outcomes when the flap is compromised.
Study DesignRetrospective chart review of 1,883 free flaps performed between July 1998 and June 2014 at a tertiary referral center.
MethodsPatients with free flap compromise due to hematoma were identified. Etiology, demographic data, and outcomes were evaluated.
ResultsEighty-eight (4.7%) patients developed hematomas. Twenty (22.7%) of those had flap compromise. Twelve compromises (60%) showed evidence of pedicle thrombosis. The salvage rate was 75% versus 54% in 79 flaps with compromise from other causes (P=.12). Mean time to detection of the hematoma was 35.3 hours in salvaged flaps compared to 91.6 hours in unsalvageable flaps (P=.057). Time to operating room (OR) from detection was 2.8 hours in salvageable flaps compared to 12.4 hours in nonsalvageable flaps (P=.053). The salvage rate for flaps that returned to the OR in <5 hours was 93.3% compared to 20% (P=.0049) for those that did not. Vascular thrombosis reduced salvage rate to 58.3% from 100% (P=.002) when there was no thrombosis.
ConclusionsIn our series hematomas developed rarely. When they did, 23% went on to develop flap compromise. Prompt recognition and re-exploration allowed for a high salvage rate. Vessel thrombosis predicted inability to salvage the flap.
Level of Evidence4 Laryngoscope, 125:1811-1815, 2015
C1 [Ahmad, Faisal I.; Gerecci, Deniz; Gonzalez, Javier D.; Wax, Mark K.] Oregon Hlth & Sci Univ, Dept Otolaryngol Head & Neck Surg, Portland, OR 97239 USA.
[Peck, Jessica J.] Dwight D Eisenhower Army Med Ctr, Dept Otolaryngol Head & Neck Surg, Ft Gordon, GA USA.
RP Wax, MK (reprint author), Oregon Hlth & Sci Univ, Dept Otolaryngol Head & Neck Surg, 3181 SW Sam Jackson Pk Rd,PV01, Portland, OR 97239 USA.
EM waxm@ohsu.edu
OI Gerecci, Deniz/0000-0002-0594-2828
NR 18
TC 1
Z9 1
U1 0
U2 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0023-852X
EI 1531-4995
J9 LARYNGOSCOPE
JI Laryngoscope
PD AUG
PY 2015
VL 125
IS 8
BP 1811
EP 1815
DI 10.1002/lary.25285
PG 5
WC Medicine, Research & Experimental; Otorhinolaryngology
SC Research & Experimental Medicine; Otorhinolaryngology
GA CN4DJ
UT WOS:000358379700019
PM 25877478
ER
PT J
AU Ahmad, FI
O'Dell, K
Peck, JJ
Wax, MK
Milczuk, HA
AF Ahmad, Faisal I.
O'Dell, Karla
Peck, Jessica J.
Wax, Mark K.
Milczuk, Henry A.
TI Pediatric airway reconstruction with a prefabricated auricular cartilage
and radial forearm free flap
SO LARYNGOSCOPE
LA English
DT Article
DE Pediatric; microvascular; sublottic stenosis; graft free tissue transfer
ID LARYNGOTRACHEAL RECONSTRUCTION; MANAGEMENT; STENOSIS
AB Prefabricated composite free flaps for complex airway reconstruction have been described for an adult series at our institution. We extended this approach to a pediatric patient with lifelong subglottic stenosis who had failed previous open airway reconstructions. A staged procedure was utilized in which a composite graft was created using conchal cartilages and a radial forearm free flap. This reconstruction improved the patency of her airway and decreased her dependency on intermittent airway dilations. Airway reconstruction with prefabricated conchal cartilage composite free flaps may be used as a salvage procedure for complex pediatric airway reconstruction when other methods have failed. Laryngoscope, 125:1979-1982, 2015
C1 [Ahmad, Faisal I.; Wax, Mark K.; Milczuk, Henry A.] Oregon Hlth & Sci Univ, Dept Otolaryngol Head & Neck Surg, Portland, OR 97239 USA.
[O'Dell, Karla] Univ So Calif, Dept Otolaryngol Head & Neck Surg, Los Angeles, CA USA.
[Peck, Jessica J.] Dwight D Eisenhower Army Med Ctr, Dept Otolaryngol Head & Neck Surg, Ft Gordon, GA USA.
RP Milczuk, HA (reprint author), Oregon Hlth & Sci Univ, Dept Otolaryngol Head & Neck Surg, 3181 SW Sam Jackson Pk Rd,PV01, Portland, OR 97239 USA.
EM milczukh@ohsu.edu
NR 9
TC 1
Z9 1
U1 1
U2 1
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0023-852X
EI 1531-4995
J9 LARYNGOSCOPE
JI Laryngoscope
PD AUG
PY 2015
VL 125
IS 8
BP 1979
EP 1982
DI 10.1002/lary.25128
PG 4
WC Medicine, Research & Experimental; Otorhinolaryngology
SC Research & Experimental Medicine; Otorhinolaryngology
GA CN4DJ
UT WOS:000358379700049
PM 25645935
ER
EF